KEGG_ko arc_domain_prop bac_domain_prop Gene Map Pathway alignment_length highest_COG_cat difference_1st_and_2nd categories COG_freq COG_cat archaea bacteria alternative_COGs COG_perc COG COG_NAME COG_TAG sequences Arc_prop Bac_prop constrained_median ML_median MEAN_OF_MEDIANS RANGE_OF_MEDIANS Probable_and_sampling_threshold_met Possible_and_sampling_threshold_met Probable Possible K00001 0.3771428571428571 0.4928774928774929 E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1] path:map00010,path:map00071,path:map00350,path:map00620,path:map00625,path:map00626,path:map00830,path:map00980,path:map00982,path:map01100,path:map01110,path:map01120,path:map01220 Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Naphthalene degradation,Retinol metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds 5.0 520.0 451.0 6.0 0.796324655436447 C 287.0 328.0 11.0 0.300153139356815 COG1454 Alcohol_dehydrogenase,_class_IV EutG 615.0 0.4666666666666667 0.5333333333333333 0.194275990456546 0.102987002424833 0.1486314964406895 0.091288988031713 0 0 0 0 K00002 0.0628571428571428 0.0427350427350427 AKR1A1, adh; alcohol dehydrogenase (NADP+) [EC:1.1.1.2] path:map00010,path:map00040,path:map00053,path:map00561,path:map00620,path:map00930,path:map01100,path:map01110,path:map01120,path:map01220,path:map01240,path:map05208 Glycolysis / Gluconeogenesis,Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Glycerolipid metabolism,Pyruvate metabolism,Caprolactam degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds,Biosynthesis of cofactors,Chemical carcinogenesis - reactive oxygen species 166.0 23.0 7.0 3.0 0.575 S 25.0 15.0 3.0 0.675 COG0656 Aldo/keto_reductase,_related_to_diketogulonate_reductase ARA1 40.0 0.625 0.375 0.20633086260642 0.613846513940362 0.410088688273391 0.4075156513339421 0 0 0 0 K00003 0.5457142857142857 0.6837606837606838 hom; homoserine dehydrogenase [EC:1.1.1.3] path:map00260,path:map00270,path:map00300,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 143.0 467.0 461.0 7.0 0.966873706004141 E 206.0 284.0 12.0 0.912244897959184 COG0460 Homoserine_dehydrogenase ThrA 490.0 0.4204081632653061 0.5795918367346938 0.2718022559263 0.220059463827158 0.2459308598767289 0.0517427920991419 0 0 0 0 K00004 0.0428571428571428 0.150997150997151 BDH, butB; (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.4 1.1.1.- 1.1.1.303] path:map00650,path:map01110 Butanoate metabolism,Biosynthesis of secondary metabolites 177.0 58.0 29.0 2.0 0.666666666666667 E 18.0 69.0 2.0 0.896551724137931 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 87.0 0.2068965517241379 0.7931034482758621 0.248537165346187 0.566249140479161 0.407393152912674 0.317711975132974 0 0 0 0 K00005 0.04 0.131054131054131 gldA; glycerol dehydrogenase [EC:1.1.1.6] path:map00561,path:map00640,path:map01100 Glycerolipid metabolism,Propanoate metabolism,Metabolic pathways 268.0 68.0 0.0 1.0 1.0 C 14.0 54.0 1.0 1.0 COG0371 Glycerol_dehydrogenase_or_related_enzyme,_iron-containing_ADH_family GldA 68.0 0.2058823529411764 0.7941176470588235 0.0417771508709893 0.485340039802844 0.2635585953369166 0.4435628889318547 0 0 0 0 K00007 0.0 0.0085470085470085 dalD; D-arabinitol 4-dehydrogenase [EC:1.1.1.11] path:map00040,path:map00051,path:map01100 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways 209.0 3.0 2.0 2.0 0.75 G 0.0 4.0 1.0 1.0 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 4.0 0.0 1.0 0.0685776791932756 0.130493780176677 0.0995357296849763 0.0619161009834014 0 0 0 0 K00008 0.2514285714285714 0.3247863247863248 SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14] path:map00040,path:map00051,path:map01100 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways 58.0 284.0 185.0 2.0 0.741514360313316 E 139.0 244.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 383.0 0.3629242819843342 0.6370757180156658 0.882354121975283 0.951455037980409 0.916904579977846 0.069100916005126 1 1 1 1 K00009 0.0 0.1196581196581196 mtlD; mannitol-1-phosphate 5-dehydrogenase [EC:1.1.1.17] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 246.0 39.0 25.0 2.0 0.735849056603773 G 0.0 53.0 1.0 1.0 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 53.0 0.0 1.0 0.0424117008002762 0.0706183806962363 0.0565150407482562 0.02820667989596 0 0 0 0 K00010 0.0542857142857142 0.1823361823361823 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369] path:map00521,path:map00562,path:map01100,path:map01110,path:map01120 Streptomycin biosynthesis,Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 137.0 145.0 140.0 5.0 0.935483870967742 S 24.0 133.0 3.0 0.980891719745223 COG0673 Predicted_dehydrogenase MviM 157.0 0.1528662420382165 0.8471337579617835 0.008025452998741 0.117300050730234 0.0626627518644875 0.109274597731493 0 0 0 0 K00011 0.0 0.0056980056980056 AKR1B; aldehyde reductase [EC:1.1.1.21] path:map00040,path:map00051,path:map00052,path:map00561,path:map00790,path:map01100 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Galactose metabolism,Glycerolipid metabolism,Folate biosynthesis,Metabolic pathways 276.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG0656 Aldo/keto_reductase,_related_to_diketogulonate_reductase ARA1 2.0 0.0 1.0 0 0 0 0 K00012 0.4657142857142857 0.7777777777777778 UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22] path:map00040,path:map00053,path:map00520,path:map00541,path:map01100,path:map01240,path:map01250 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Biosynthesis of nucleotide sugars 227.0 419.0 302.0 5.0 0.77449168207024 M 198.0 343.0 5.0 0.948243992606285 COG1004 UDP-glucose_6-dehydrogenase Ugd 541.0 0.3659889094269871 0.634011090573013 0.856337242020776 0.948713184483518 0.9025252132521472 0.092375942462742 1 1 1 1 K00013 0.4971428571428571 0.7464387464387464 hisD; histidinol dehydrogenase [EC:1.1.1.23] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 271.0 454.0 451.0 5.0 0.982683982683983 E 180.0 282.0 4.0 0.976190476190476 COG0141 Histidinol_dehydrogenase HisD 462.0 0.3896103896103896 0.6103896103896104 0.4224409109356 0.885363262281639 0.6539020866086195 0.462922351346039 0 0 0 0 K00014 0.5285714285714286 0.7977207977207977 aroE; shikimate dehydrogenase [EC:1.1.1.25] path:map00400,path:map00999,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 91.0 514.0 506.0 5.0 0.955390334572491 E 192.0 347.0 7.0 0.968460111317254 COG0169 Shikimate_5-dehydrogenase AroE 539.0 0.3562152133580705 0.6437847866419295 0.0037637290417906 0.0681089277268374 0.035936328384314 0.0643451986850467 0 0 0 0 K00015 0.2428571428571428 0.3817663817663818 gyaR, GOR1; glyoxylate reductase [EC:1.1.1.26] path:map00630,path:map01100,path:map01110,path:map01120 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 166.0 136.0 15.0 5.0 0.485714285714286 C 106.0 174.0 2.0 0.925 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 280.0 0.3785714285714285 0.6214285714285714 0.0665749365698938 0.75979429301278 0.4131846147913369 0.6932193564428862 0 0 0 0 K00016 0.0485714285714285 0.2877492877492877 LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27] path:map00010,path:map00270,path:map00620,path:map00640,path:map01100,path:map01110,path:map01120,path:map04066,path:map04922,path:map05230 Glycolysis / Gluconeogenesis,Cysteine and methionine metabolism,Pyruvate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,HIF-1 signaling pathway,Glucagon signaling pathway,Central carbon metabolism in cancer 226.0 154.0 0.0 1.0 1.0 C 19.0 135.0 2.0 0.961038961038961 COG0039 Malate/lactate_dehydrogenase Mdh 154.0 0.1233766233766233 0.8766233766233766 0.649142655750048 0.897785014230616 0.773463834990332 0.2486423584805679 0 1 0 1 K00018 0.0971428571428571 0.2136752136752136 hprA; glycerate dehydrogenase [EC:1.1.1.29] path:map00260,path:map00630,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 207.0 65.0 5.0 4.0 0.492424242424242 CH 43.0 89.0 2.0 0.916666666666667 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 132.0 0.3257575757575757 0.6742424242424242 0.0181737340796171 0.333978252214456 0.1760759931470365 0.3158045181348389 0 0 0 0 K00019 0.0714285714285714 0.2222222222222222 BDH1, bdhA; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 217.0 99.0 75.0 3.0 0.792 IQ 28.0 97.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 125.0 0.224 0.776 0.0040051468793406 0.0497994801216016 0.0269023135004711 0.0457943332422609 0 0 0 0 K00020 0.18 0.4159544159544159 HIBADH, mmsB; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 109.0 307.0 246.0 3.0 0.82972972972973 I 92.0 278.0 5.0 0.964864864864865 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 370.0 0.2486486486486486 0.7513513513513513 0.0037974375442061 0.112727877421083 0.0582626574826445 0.1089304398768769 0 0 0 0 K00021 0.46 0.0598290598290598 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] path:map00900,path:map01100,path:map01110,path:map04152,path:map04976 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,AMPK signaling pathway,Bile secretion 274.0 187.0 182.0 3.0 0.968911917098446 I 170.0 23.0 2.0 0.994818652849741 COG1257 Hydroxymethylglutaryl-CoA_reductase HMG1 193.0 0.8808290155440415 0.1191709844559585 0.3008070030733 0.532043968802929 0.4164254859381145 0.231236965729629 0 0 0 0 K00023 0.08 0.1538461538461538 phbB; acetoacetyl-CoA reductase [EC:1.1.1.36] path:map00630,path:map00650,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 185.0 74.0 50.0 3.0 0.747474747474748 IQ 28.0 71.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 99.0 0.2828282828282828 0.7171717171717171 0.0319360884789845 0.279813983441991 0.1558750359604877 0.2478778949630065 0 0 0 0 K00024 0.4514285714285714 0.6267806267806267 mdh; malate dehydrogenase [EC:1.1.1.37] path:map00020,path:map00270,path:map00620,path:map00630,path:map00680,path:map00710,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Cysteine and methionine metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 199.0 420.0 0.0 1.0 1.0 C 175.0 245.0 1.0 1.0 COG0039 Malate/lactate_dehydrogenase Mdh 420.0 0.4166666666666667 0.5833333333333334 0.792010623754843 0.640242972962672 0.7161267983587575 0.151767650792171 1 1 1 1 K00027 0.4314285714285714 0.5584045584045584 ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] path:map00620,path:map01200,path:map02020 Pyruvate metabolism,Carbon metabolism,Two-component system 279.0 414.0 0.0 1.0 1.0 C 168.0 246.0 3.0 0.905797101449275 COG0281 Malic_enzyme SfcA 414.0 0.4057971014492754 0.5942028985507246 0.888499436970371 0.890796490223175 0.889647963596773 0.0022970532528039 1 1 1 1 K00029 0.34 0.3903133903133903 E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] path:map00620,path:map00710,path:map01100,path:map01120,path:map01200,path:map03320 Pyruvate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,PPAR signaling pathway 332.0 319.0 0.0 1.0 1.0 C 146.0 173.0 2.0 0.639498432601881 COG0281 Malic_enzyme SfcA 319.0 0.457680250783699 0.542319749216301 0.136536225479275 0.0319978082527603 0.0842670168660176 0.1045384172265146 0 0 0 0 K00030 0.1971428571428571 0.1965811965811965 IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41] path:map00020,path:map01100,path:map01110,path:map01120,path:map01200,path:map01210,path:map01230 Citrate cycle (TCA cycle),Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 276.0 109.0 51.0 2.0 0.652694610778443 C 88.0 79.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 167.0 0.5269461077844312 0.4730538922155688 0.449707719589317 0.954740371846841 0.7022240457180791 0.505032652257524 0 0 0 0 K00031 0.4085714285714286 0.6609686609686609 IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42] path:map00020,path:map00480,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01210,path:map01230,path:map04146,path:map05230 Citrate cycle (TCA cycle),Glutathione metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Peroxisome,Central carbon metabolism in cancer 255.0 412.0 392.0 5.0 0.934240362811791 C 152.0 288.0 6.0 0.630385487528345 COG0538 Isocitrate_dehydrogenase Icd 440.0 0.3454545454545454 0.6545454545454545 0.531099251510428 0.100121110119777 0.3156101808151025 0.430978141390651 0 1 0 1 K00032 0.0 0.0113960113960113 E1.1.1.43; phosphogluconate 2-dehydrogenase [EC:1.1.1.43] path:map00030,path:map00480,path:map01100,path:map01120 Pentose phosphate pathway,Glutathione metabolism,Metabolic pathways,Microbial metabolism in diverse environments 306.0 3.0 2.0 2.0 0.75 CH 0.0 4.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 4.0 0.0 1.0 4.24413245163553e-12 3.01761776400869e-08 1.5090210886269273e-08 3.0171933507635265e-08 0 0 0 0 K00033 0.18 0.5014245014245015 PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] path:map00030,path:map00480,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Glutathione metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 246.0 219.0 173.0 4.0 0.77112676056338 G 66.0 218.0 5.0 0.514084507042254 COG1023 6-phosphogluconate_dehydrogenase_(decarboxylating) YqeC 284.0 0.2323943661971831 0.7676056338028169 0.139276831870307 0.734714135930648 0.4369954839004775 0.595437304060341 0 0 0 0 K00034 0.1085714285714285 0.2222222222222222 gdh; glucose 1-dehydrogenase [EC:1.1.1.47] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 167.0 108.0 77.0 3.0 0.771428571428571 IQ 42.0 98.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 140.0 0.3 0.7 0.0458253997914452 0.152894795639941 0.0993600977156931 0.1070693958484957 0 0 0 0 K00035 0.0 0.017094017094017 gal; D-galactose 1-dehydrogenase [EC:1.1.1.48] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 305.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 6.0 0.0 1.0 1.10480308642714e-06 1.3198462305548e-05 7.15163269598757e-06 1.209365921912086e-05 0 0 0 0 K00036 0.0485714285714285 0.5156695156695157 G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] path:map00030,path:map00480,path:map01100,path:map01110,path:map01120,path:map01200,path:map05230,path:map05415 Pentose phosphate pathway,Glutathione metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Central carbon metabolism in cancer,Diabetic cardiomyopathy 306.0 238.0 232.0 4.0 0.944444444444444 G 19.0 233.0 3.0 0.976190476190476 COG0364 Glucose-6-phosphate_1-dehydrogenase Zwf 252.0 0.0753968253968253 0.9246031746031746 0.0302149117772282 0.952055331549306 0.4911351216632671 0.9218404197720778 0 0 0 0 K00038 0.0085714285714285 0.0854700854700854 E1.1.1.53; 3alpha(or 20beta)-hydroxysteroid dehydrogenase [EC:1.1.1.53] path:map00140,path:map01100 Steroid hormone biosynthesis,Metabolic pathways 200.0 44.0 43.0 3.0 0.956521739130435 IQ 3.0 43.0 2.0 0.978260869565217 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 46.0 0.0652173913043478 0.9347826086956522 0.0123331200337436 0.0105358531029958 0.0114344865683697 0.0017972669307477 0 0 0 0 K00039 0.0 0.0113960113960113 rbtD; ribitol 2-dehydrogenase [EC:1.1.1.56] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 242.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 4.0 0.0 1.0 0.0227428598497069 0.0516407264515901 0.0371917931506484 0.0288978666018831 0 0 0 0 K00040 0.0 0.1452991452991453 uxuB; fructuronate reductase [EC:1.1.1.57] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 312.0 65.0 58.0 2.0 0.902777777777778 G 0.0 72.0 2.0 0.958333333333333 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 72.0 0.0 1.0 0.0082205759850673 0.0187240616985474 0.0134723188418073 0.0105034857134801 0 0 0 0 K00041 0.0057142857142857 0.1225071225071225 uxaB; tagaturonate reductase [EC:1.1.1.58] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 340.0 40.0 30.0 3.0 0.784313725490196 G 2.0 49.0 2.0 0.980392156862745 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 51.0 0.0392156862745098 0.9607843137254902 0.094099652722514 0.0569886088293349 0.0755441307759244 0.037111043893179 0 0 0 0 K00042 0.0285714285714285 0.2507122507122507 garR, glxR; 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 227.0 133.0 124.0 3.0 0.93006993006993 I 10.0 133.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 143.0 0.0699300699300699 0.93006993006993 0.001959684898079 0.445770030342897 0.223864857620488 0.4438103454448179 0 0 0 0 K00043 0.0 0.0683760683760683 gbd; 4-hydroxybutyrate dehydrogenase [EC:1.1.1.61] path:map00650,path:map01100,path:map01200 Butanoate metabolism,Metabolic pathways,Carbon metabolism 340.0 29.0 0.0 1.0 1.0 C 0.0 29.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 29.0 0.0 1.0 0.0337998949871767 0.0810269661986876 0.0574134305929321 0.0472270712115109 0 0 0 0 K00045 0.0 0.0769230769230769 E1.1.1.67, mtlK; mannitol 2-dehydrogenase [EC:1.1.1.67] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 435.0 25.0 16.0 2.0 0.735294117647059 G 0.0 34.0 1.0 1.0 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 34.0 0.0 1.0 0.04483020223197 0.11223419395492 0.078532198093445 0.06740399172295 0 0 0 0 K00046 0.0657142857142857 0.3133903133903133 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] 177.0 178.0 169.0 3.0 0.946808510638298 IQ 25.0 163.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 188.0 0.1329787234042553 0.8670212765957447 0.0075239711054495 0.168302161675429 0.0879130663904392 0.1607781905699795 0 0 0 0 K00048 0.0085714285714285 0.0484330484330484 fucO; lactaldehyde reductase [EC:1.1.1.77] path:map00630,path:map00640,path:map01100,path:map01120 Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 359.0 22.0 0.0 1.0 1.0 C 3.0 19.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 22.0 0.1363636363636363 0.8636363636363636 0.156047907039666 0.351657018161669 0.2538524626006675 0.195609111122003 0 0 0 0 K00050 0.0 0.0199430199430199 314.0 6.0 2.0 2.0 0.6 C 0.0 10.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 10.0 0.0 1.0 0.0071489766929288 0.0111391900520136 0.0091440833724712 0.0039902133590848 0 0 0 0 K00052 0.5628571428571428 0.7635327635327636 leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] path:map00290,path:map00660,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,C5-Branched dibasic acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 220.0 306.0 90.0 3.0 0.564575645756458 C 225.0 317.0 2.0 0.998154981549816 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 542.0 0.4151291512915129 0.584870848708487 0.83512550578264 0.660496393093507 0.7478109494380736 0.1746291126891329 1 1 1 1 K00053 0.4914285714285714 0.7350427350427351 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] path:map00290,path:map00770,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 277.0 177.0 22.0 4.0 0.392461197339246 E 185.0 266.0 1.0 1.0 COG0059 Ketol-acid_reductoisomerase IlvC 451.0 0.4101995565410199 0.5898004434589801 0.0084268920546985 0.0693197504909525 0.0388733212728255 0.060892858436254 0 0 0 0 K00054 0.4371428571428571 0.1168091168091168 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 341.0 183.0 159.0 2.0 0.884057971014493 I 160.0 47.0 4.0 0.966183574879227 COG1257 Hydroxymethylglutaryl-CoA_reductase HMG1 207.0 0.7729468599033816 0.2270531400966183 0.521891052018022 0.872420816148702 0.697155934083362 0.35052976413068 0 1 0 1 K00055 0.02 0.0626780626780626 E1.1.1.90; aryl-alcohol dehydrogenase [EC:1.1.1.90] path:map00350,path:map00360,path:map00622,path:map00623,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Phenylalanine metabolism,Xylene degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 343.0 35.0 0.0 1.0 1.0 C 7.0 28.0 1.0 1.0 COG1062 Zn-dependent_alcohol/formaldehyde_dehydrogenase FrmA 35.0 0.2 0.8 0.0266583852687475 0.0517366370279477 0.0391975111483476 0.0250782517592002 0 0 0 0 K00057 0.0714285714285714 0.8433048433048433 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 165.0 283.0 231.0 3.0 0.842261904761905 I 26.0 310.0 1.0 1.0 COG0240 Glycerol-3-phosphate_dehydrogenase GpsA 336.0 0.0773809523809523 0.9226190476190476 0.0132539865898681 0.0269985601377367 0.0201262733638023 0.0137445735478685 0 0 0 0 K00058 0.6885714285714286 0.8404558404558404 serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] path:map00260,path:map00270,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 56.0 311.0 56.0 9.0 0.324973876698015 EH 356.0 602.0 8.0 0.764522821576763 COG0111 Phosphoglycerate_dehydrogenase_or_related_dehydrogenase SerA 958.0 0.37160751565762 0.6283924843423799 0.177598704089181 0.0408304270053054 0.1092145655472432 0.1367682770838756 0 0 0 0 K00059 0.6028571428571429 0.8917378917378918 fabG, OAR1; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] path:map00061,path:map00333,path:map00780,path:map01100,path:map01110,path:map01212,path:map01240 Fatty acid biosynthesis,Prodigiosin biosynthesis,Biotin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism,Biosynthesis of cofactors 28.0 1449.0 1016.0 6.0 0.737029501525941 IQ 591.0 1363.0 6.0 0.960834181078332 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1954.0 0.3024564994882293 0.6975435005117707 0 0 0 0 K00060 0.1057142857142857 0.2792022792022792 tdh; threonine 3-dehydrogenase [EC:1.1.1.103] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 202.0 79.0 2.0 3.0 0.503184713375796 E 41.0 116.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 157.0 0.2611464968152866 0.7388535031847133 0.91822146445961 0.885053255747092 0.9016373601033508 0.0331682087125179 1 1 1 1 K00064 0.0028571428571428 0.1111111111111111 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] path:map00051,path:map00053,path:map01100,path:map01110,path:map01120 Fructose and mannose metabolism,Ascorbate and aldarate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 241.0 62.0 0.0 1.0 1.0 C 1.0 61.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 62.0 0.0161290322580645 0.9838709677419356 0.0167455798822506 0.0639522055257379 0.0403488927039942 0.0472066256434872 0 0 0 0 K00065 0.0142857142857142 0.2621082621082621 kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 172.0 130.0 0.0 1.0 1.0 IQ 5.0 125.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 130.0 0.0384615384615384 0.9615384615384616 0.0040570145296068 0.252591141705545 0.1283240781175758 0.2485341271759381 0 0 0 0 K00066 0.0171428571428571 0.094017094017094 algD; GDP-mannose 6-dehydrogenase [EC:1.1.1.132] path:map00051,path:map00520,path:map01100,path:map01250,path:map02020 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars,Two-component system 272.0 31.0 20.0 2.0 0.738095238095238 M 6.0 36.0 2.0 0.738095238095238 COG1004 UDP-glucose_6-dehydrogenase Ugd 42.0 0.1428571428571428 0.8571428571428571 0.306821855504025 0.357436949064839 0.332129402284432 0.050615093560814 0 0 0 0 K00067 0.3371428571428571 0.6837606837606838 rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] path:map00521,path:map00523,path:map00541,path:map01100,path:map01110,path:map01250 Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 65.0 451.0 430.0 6.0 0.916666666666667 M 139.0 352.0 6.0 0.932926829268293 COG1091 dTDP-4-dehydrorhamnose_reductase RfbD 491.0 0.2830957230142566 0.7169042769857433 0.0483690390677354 0.197548368746475 0.1229587039071052 0.1491793296787396 0 0 0 0 K00068 0.0428571428571428 0.1282051282051282 srlD; sorbitol-6-phosphate 2-dehydrogenase [EC:1.1.1.140] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 161.0 57.0 48.0 3.0 0.802816901408451 IQ 16.0 55.0 2.0 0.816901408450704 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 71.0 0.2253521126760563 0.7746478873239436 0.0381937529130566 0.222463701331126 0.1303287271220913 0.1842699484180694 0 0 0 0 K00070 0.0057142857142857 0.0 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] path:map00140,path:map01100,path:map04913,path:map04925,path:map04927,path:map04934 Steroid hormone biosynthesis,Metabolic pathways,Ovarian steroidogenesis,Aldosterone synthesis and secretion,Cortisol synthesis and secretion,Cushing syndrome 360.0 2.0 0.0 1.0 1.0 C 2.0 0.0 1.0 1.0 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 2.0 1.0 0.0 0 0 0 0 K00073 0.0057142857142857 0.0655270655270655 allD; ureidoglycolate dehydrogenase (NAD+) [EC:1.1.1.350] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 260.0 46.0 0.0 1.0 1.0 C 2.0 44.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 46.0 0.0434782608695652 0.9565217391304348 0.008338242656295 0.016187639385184 0.0122629410207395 0.007849396728889 0 0 0 0 K00074 0.3657142857142857 0.4672364672364672 paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157] path:map00360,path:map00362,path:map00650,path:map01100,path:map01120,path:map01200 Phenylalanine metabolism,Benzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 164.0 465.0 398.0 2.0 0.87406015037594 I 219.0 313.0 3.0 0.973684210526316 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 532.0 0.4116541353383459 0.5883458646616542 0.227626497032715 0.765922475438865 0.49677448623579 0.5382959784061501 0 0 0 0 K00075 0.0085714285714285 0.9344729344729344 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] path:map00520,path:map00550,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Peptidoglycan biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 97.0 344.0 326.0 5.0 0.934782608695652 M 3.0 365.0 5.0 0.921195652173913 COG0812 UDP-N-acetylenolpyruvoylglucosamine_reductase MurB 368.0 0.0081521739130434 0.9918478260869564 0.0624129275994087 0.0521649978463656 0.0572889627228871 0.0102479297530431 0 0 0 0 K00076 0.0057142857142857 0.0769230769230769 hdhA; 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159] path:map00121 Secondary bile acid biosynthesis 211.0 31.0 0.0 1.0 1.0 IQ 2.0 29.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 31.0 0.064516129032258 0.935483870967742 0.0184899690930853 0.11874702445452 0.0686184967738026 0.1002570553614347 0 0 0 0 K00077 0.3914285714285714 0.4814814814814814 panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] path:map00770,path:map01100,path:map01110,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 22.0 401.0 391.0 9.0 0.926096997690531 H 171.0 261.0 8.0 0.928406466512702 COG1893 Ketopantoate_reductase PanE 432.0 0.3958333333333333 0.6041666666666666 0.321622084692415 0.548113065615101 0.4348675751537579 0.226490980922686 0 0 0 0 K00082 0.0028571428571428 0.168091168091168 ribD2; 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 115.0 71.0 70.0 2.0 0.986111111111111 H 1.0 71.0 2.0 0.888888888888889 COG1985 Pyrimidine_reductase,_riboflavin_biosynthesis RibD 72.0 0.0138888888888888 0.9861111111111112 0.0219488376039399 0.488767581086326 0.255358209345133 0.4668187434823861 0 0 0 0 K00086 0.02 0.0541310541310541 dhaT; 1,3-propanediol dehydrogenase [EC:1.1.1.202] path:map00561,path:map00640,path:map01100 Glycerolipid metabolism,Propanoate metabolism,Metabolic pathways 313.0 29.0 0.0 1.0 1.0 C 7.0 22.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 29.0 0.2413793103448276 0.7586206896551724 0.279681872546856 0.0907059213829381 0.185193896964897 0.1889759511639179 0 0 0 0 K00087 0.0171428571428571 0.0883190883190883 ygeS, xdhA; xanthine dehydrogenase molybdenum-binding subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 124.0 44.0 38.0 5.0 0.785714285714286 C 8.0 47.0 6.0 0.696428571428571 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 55.0 0.1454545454545454 0.8545454545454545 0.702921991858595 0.836458482938849 0.769690237398722 0.1335364910802539 0 1 0 1 K00088 0.4628571428571428 0.8888888888888888 IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] path:map00230,path:map00983,path:map01100,path:map01110,path:map01232 Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 295.0 541.0 520.0 3.0 0.940869565217391 F 196.0 379.0 2.0 0.99304347826087 COG0516 IMP_dehydrogenase/GMP_reductase GuaB 575.0 0.3408695652173913 0.6591304347826087 0.0067324477630106 0.789673159064752 0.3982028034138813 0.7829407113017414 0 0 0 0 K00090 0.0028571428571428 0.0655270655270655 ghrB; glyoxylate/hydroxypyruvate/2-ketogluconate reductase [EC:1.1.1.79 1.1.1.81 1.1.1.215] path:map00030,path:map00260,path:map00620,path:map00630,path:map01100,path:map01110,path:map01120 Pentose phosphate pathway,Glycine, serine and threonine metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 273.0 19.0 14.0 3.0 0.76 CH 1.0 24.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 25.0 0.04 0.96 0.0159626985750861 0.0547341640875062 0.0353484313312961 0.0387714655124201 0 0 0 0 K00091 0.1142857142857142 0.3076923076923077 E1.1.1.219; dihydroflavonol-4-reductase [EC:1.1.1.219] 107.0 135.0 83.0 2.0 0.72192513368984 M 43.0 144.0 2.0 0.978609625668449 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 187.0 0.2299465240641711 0.7700534759358288 0.330059222629161 0.0086361701775897 0.1693476964033753 0.3214230524515712 0 0 0 0 K00094 0.0 0.0142450142450142 E1.1.1.251, gatD; galactitol-1-phosphate 5-dehydrogenase [EC:1.1.1.251] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 346.0 4.0 3.0 2.0 0.8 E 0.0 5.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 5.0 0.0 1.0 0.0521863377894105 0.111194060300111 0.0816901990447607 0.0590077225107005 0 0 0 0 K00096 0.6457142857142857 0.0911680911680911 araM, egsA; glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 223.0 271.0 0.0 1.0 1.0 C 236.0 35.0 1.0 1.0 COG0371 Glycerol_dehydrogenase_or_related_enzyme,_iron-containing_ADH_family GldA 271.0 0.8708487084870848 0.1291512915129151 0.959246078527595 0.226410695653359 0.592828387090477 0.732835382874236 1 1 1 1 K00097 0.0257142857142857 0.5042735042735043 pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 200.0 152.0 106.0 2.0 0.767676767676768 H 9.0 189.0 1.0 1.0 COG1995 4-hydroxy-L-threonine_phosphate_dehydrogenase_PdxA PdxA 198.0 0.0454545454545454 0.9545454545454546 0.254377396991431 0.151776759094146 0.2030770780427885 0.102600637897285 0 0 0 0 K00098 0.0028571428571428 0.0512820512820512 idnD; L-idonate 5-dehydrogenase [EC:1.1.1.264] 320.0 22.0 19.0 2.0 0.88 E 1.0 24.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 25.0 0.04 0.96 0.0113496277221678 0.0300659704662941 0.0207077990942309 0.0187163427441263 0 0 0 0 K00099 0.0057142857142857 0.7578347578347578 dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 263.0 266.0 263.0 3.0 0.985185185185185 I 2.0 268.0 2.0 0.996296296296296 COG0743 1-deoxy-D-xylulose_5-phosphate_reductoisomerase Dxr 270.0 0.0074074074074074 0.9925925925925926 0.293813694799444 0.0275419219879808 0.1606778083937124 0.2662717728114632 0 0 0 0 K00100 0.0 0.0455840455840455 bdhAB; butanol dehydrogenase [EC:1.1.1.-] path:map00650,path:map01100,path:map01120 Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 355.0 18.0 0.0 1.0 1.0 C 0.0 18.0 2.0 0.944444444444444 COG1979 Alcohol_dehydrogenase_YqhD,_Fe-dependent_ADH_family YqdH 18.0 0.0 1.0 0.875931449672794 0.390563965867637 0.6332477077702154 0.485367483805157 0 0 1 1 K00101 0.0114285714285714 0.1766381766381766 lldD; L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 283.0 98.0 95.0 2.0 0.97029702970297 C 4.0 97.0 2.0 0.97029702970297 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 101.0 0.0396039603960396 0.9603960396039604 0.015166928708261 0.0153439964487249 0.0152554625784929 0.0001770677404638 0 0 0 0 K00102 0.2 0.2108262108262108 LDHD, dld; D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 235.0 195.0 0.0 1.0 1.0 C 89.0 106.0 2.0 0.984615384615385 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 195.0 0.4564102564102564 0.5435897435897435 0.770362311935167 0.991495857886136 0.8809290849106515 0.221133545950969 1 1 1 1 K00103 0.0085714285714285 0.0797720797720797 GULO; L-gulonolactone oxidase [EC:1.1.3.8] path:map00053,path:map01100,path:map01240 Ascorbate and aldarate metabolism,Metabolic pathways,Biosynthesis of cofactors 299.0 34.0 0.0 1.0 1.0 C 3.0 31.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 34.0 0.088235294117647 0.9117647058823528 0.0353105518247463 0.0763503435462481 0.0558304476854972 0.0410397917215018 0 0 0 0 K00104 0.3685714285714285 0.5242165242165242 glcD; glycolate oxidase [EC:1.1.3.15] path:map00630,path:map01100,path:map01110,path:map01120 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 119.0 558.0 0.0 1.0 1.0 C 264.0 293.0 3.0 0.948028673835126 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 557.0 0.473967684021544 0.526032315978456 0.298747256567204 0.547925269441084 0.423336263004144 0.2491780128738799 0 0 0 0 K00105 0.0114285714285714 0.0341880341880341 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 468.0 20.0 0.0 1.0 1.0 C 4.0 16.0 1.0 1.0 COG0578 Glycerol-3-phosphate_dehydrogenase GlpA 20.0 0.2 0.8 0.0372031549291417 0.12919171129856 0.0831974331138508 0.0919885563694183 0 0 0 0 K00106 0.0 0.0 XDH; xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] path:map00230,path:map00232,path:map00983,path:map01100,path:map01110,path:map01120,path:map01232,path:map04146 Purine metabolism,Caffeine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Nucleotide metabolism,Peroxisome 7.0 6.0 2.0 0.875 F 0.0 0.0 2.0 0.5 COG4630 Xanthine_dehydrogenase,_Fe-S_cluster_and_FAD-binding_subunit_XdhA XdhA 0.0 0 0 0 0 K00108 0.0028571428571428 0.2079772079772079 betA, CHDH; choline dehydrogenase [EC:1.1.99.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 322.0 130.0 106.0 2.0 0.844155844155844 E 1.0 153.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 154.0 0.0064935064935064 0.9935064935064936 0.0052211049399976 0.0264976530347728 0.0158593789873852 0.0212765480947752 0 0 0 0 K00109 0.0028571428571428 0.0256410256410256 L2HGDH; 2-hydroxyglutarate dehydrogenase [EC:1.1.99.2] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 355.0 5.0 0.0 2.0 0.5 C 1.0 9.0 1.0 1.0 COG0579 L-2-hydroxyglutarate_oxidase_LhgO LhgO 10.0 0.1 0.9 0.320583628791388 0.895336136082343 0.6079598824368655 0.574752507290955 0 0 0 0 K00111 0.3342857142857143 0.5384615384615384 glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 158.0 408.0 381.0 3.0 0.906666666666667 C 174.0 275.0 5.0 0.675555555555556 COG0578 Glycerol-3-phosphate_dehydrogenase GlpA 449.0 0.3875278396436525 0.6124721603563474 0.843652480768425 0.964784174882462 0.9042183278254436 0.121131694114037 1 1 1 1 K00112 0.1228571428571428 0.0569800569800569 glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 342.0 52.0 35.0 2.0 0.753623188405797 E 47.0 22.0 1.0 1.0 COG3075 Anaerobic_glycerol-3-phosphate_dehydrogenase GlpB 69.0 0.6811594202898551 0.3188405797101449 0.0050623459297392 0.706464554017973 0.3557634499738561 0.7014022080882338 0 0 0 0 K00113 0.1714285714285714 0.131054131054131 glpC; glycerol-3-phosphate dehydrogenase subunit C path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 112.0 124.0 0.0 1.0 1.0 C 76.0 48.0 4.0 0.758064516129032 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 124.0 0.6129032258064516 0.3870967741935484 0.0481026936884977 0.786412284505281 0.4172574890968893 0.7383095908167833 0 0 0 0 K00114 0.0057142857142857 0.0683760683760683 exaA; alcohol dehydrogenase (cytochrome c) [EC:1.1.2.8] path:map00010,path:map00620,path:map00625,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 455.0 46.0 45.0 2.0 0.978723404255319 G 4.0 43.0 2.0 0.936170212765958 COG4993 Glucose_dehydrogenase,_PQQ-dependent Gcd 47.0 0.0851063829787234 0.9148936170212766 0.0057100639284956 0.0118278259438835 0.0087689449361895 0.0061177620153878 0 0 0 0 K00116 0.0857142857142857 0.1367521367521367 mqo; malate dehydrogenase (quinone) [EC:1.1.5.4] path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 346.0 42.0 2.0 2.0 0.51219512195122 C 30.0 52.0 1.0 1.0 COG0579 L-2-hydroxyglutarate_oxidase_LhgO LhgO 82.0 0.3658536585365853 0.6341463414634146 0.0063763792092747 0.10575668350923 0.0560665313592523 0.0993803042999553 0 0 0 0 K00117 0.0142857142857142 0.150997150997151 gcd; quinoprotein glucose dehydrogenase [EC:1.1.5.2] path:map00030,path:map01100,path:map01110 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites 107.0 84.0 76.0 2.0 0.91304347826087 G 6.0 86.0 5.0 0.456521739130435 COG4993 Glucose_dehydrogenase,_PQQ-dependent Gcd 92.0 0.0652173913043478 0.9347826086956522 0.0238627467994442 0.121674111904119 0.0727684293517816 0.0978113651046748 0 0 0 0 K00118 0.0114285714285714 0.0712250712250712 gfo; glucose-fructose oxidoreductase [EC:1.1.99.28] 221.0 30.0 29.0 2.0 0.967741935483871 S 4.0 27.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 31.0 0.1290322580645161 0.8709677419354839 0.286957730123545 0.121164991581238 0.2040613608523915 0.1657927385423069 0 0 0 0 K00121 0.0057142857142857 0.2849002849002849 frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] path:map00010,path:map00071,path:map00350,path:map00620,path:map00625,path:map00626,path:map00680,path:map00830,path:map00980,path:map00982,path:map01100,path:map01110,path:map01120,path:map01200,path:map01220,path:map04936 Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Naphthalene degradation,Methane metabolism,Retinol metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Degradation of aromatic compounds,Alcoholic liver disease 296.0 137.0 121.0 2.0 0.895424836601307 C 2.0 151.0 2.0 0.862745098039216 COG1062 Zn-dependent_alcohol/formaldehyde_dehydrogenase FrmA 153.0 0.0130718954248366 0.9869281045751634 0.0114244971292512 0.0517878398416173 0.0316061684854342 0.0403633427123661 0 0 0 0 K00122 0.0285714285714285 0.1054131054131054 FDH; formate dehydrogenase [EC:1.17.1.9] path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 147.0 40.0 28.0 3.0 0.701754385964912 C 12.0 43.0 4.0 0.56140350877193 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 55.0 0.2181818181818181 0.7818181818181819 0.663450422447509 0.92700332828151 0.7952268753645095 0.263552905834001 0 1 0 1 K00123 0.3457142857142857 0.4387464387464387 fdoG, fdhF, fdwA; formate dehydrogenase major subunit [EC:1.17.1.9] path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 87.0 607.0 605.0 2.0 0.99671592775041 C 227.0 354.0 7.0 0.619047619047619 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 581.0 0.3907056798623063 0.6092943201376936 0.0845115370710952 0.398582267164959 0.2415469021180271 0.3140707300938637 0 0 0 0 K00124 0.16 0.2621082621082621 fdoH, fdsB; formate dehydrogenase iron-sulfur subunit path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 42.0 233.0 0.0 1.0 1.0 C 76.0 156.0 3.0 0.721030042918455 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 232.0 0.3275862068965517 0.6724137931034483 0.141262913722666 0.376055914601405 0.2586594141620355 0.2347930008787389 0 0 0 0 K00125 0.1257142857142857 0.0256410256410256 fdhB; formate dehydrogenase (coenzyme F420) beta subunit [EC:1.17.98.3 1.8.98.6] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 267.0 81.0 0.0 1.0 1.0 C 70.0 11.0 2.0 0.901234567901235 COG1035 Coenzyme_F420-reducing_hydrogenase,_beta_subunit FrhB 81.0 0.8641975308641975 0.1358024691358024 0.952650555483288 0.764668362743976 0.8586594591136321 0.187982192739312 1 1 1 1 K00126 0.0 0.0655270655270655 fdsD; formate dehydrogenase subunit delta [EC:1.17.1.9] path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 63.0 20.0 17.0 2.0 0.869565217391304 S 0.0 23.0 2.0 0.956521739130435 2E4CR 23.0 0.0 1.0 0.00474048397079 0.0119033131784134 0.0083218985746017 0.0071628292076234 0 0 0 0 K00127 0.0542857142857142 0.1623931623931624 fdoI, fdsG; formate dehydrogenase subunit gamma path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 57.0 99.0 0.0 1.0 1.0 C 22.0 77.0 4.0 0.636363636363636 COG2864 Cytochrome_b_subunit_of_formate_dehydrogenase FdnI 99.0 0.2222222222222222 0.7777777777777778 0.012730832459241 0.0396907858402936 0.0262108091497672 0.0269599533810525 0 0 0 0 K00128 0.24 0.5327635327635327 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] path:map00010,path:map00053,path:map00071,path:map00280,path:map00310,path:map00330,path:map00340,path:map00380,path:map00410,path:map00561,path:map00620,path:map00625,path:map00770,path:map00903,path:map00981,path:map01100,path:map01110,path:map01120,path:map01240,path:map04936 Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid degradation,Valine, leucine and isoleucine degradation,Lysine degradation,Arginine and proline metabolism,Histidine metabolism,Tryptophan metabolism,beta-Alanine metabolism,Glycerolipid metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Pantothenate and CoA biosynthesis,Limonene and pinene degradation,Insect hormone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors,Alcoholic liver disease 204.0 686.0 684.0 2.0 0.997093023255814 C 185.0 503.0 3.0 0.995639534883721 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 688.0 0.2688953488372093 0.7311046511627907 0.0084054626747215 0.0182305847243305 0.013318023699526 0.009825122049609 0 0 0 0 K00129 0.0085714285714285 0.0484330484330484 ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5] path:map00010,path:map00340,path:map00350,path:map00360,path:map00410,path:map00980,path:map00982,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Histidine metabolism,Tyrosine metabolism,Phenylalanine metabolism,beta-Alanine metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 437.0 24.0 0.0 1.0 1.0 C 5.0 19.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 24.0 0.2083333333333333 0.7916666666666666 0.0122031416434837 0.0352361310872041 0.0237196363653439 0.0230329894437204 0 0 0 0 K00130 0.1142857142857142 0.2364672364672364 betB, gbsA; betaine-aldehyde dehydrogenase [EC:1.2.1.8] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 362.0 213.0 0.0 1.0 1.0 C 42.0 171.0 2.0 0.995305164319249 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 213.0 0.1971830985915492 0.8028169014084507 0.0479545526509669 0.303787115608443 0.1758708341297049 0.2558325629574761 0 0 0 0 K00131 0.0257142857142857 0.1424501424501424 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] path:map00010,path:map00030,path:map01100,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 383.0 67.0 0.0 1.0 1.0 C 10.0 57.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 67.0 0.1492537313432835 0.8507462686567164 0.866502653635309 0.0653184793798897 0.4659105665075993 0.8011841742554193 1 1 1 1 K00132 0.0 0.0341880341880341 E1.2.1.10; acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10] path:map00620,path:map00650,path:map01100,path:map01120 Pyruvate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 434.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 12.0 0.0 1.0 0.0451395029619901 0.101933002148169 0.0735362525550795 0.0567934991861789 0 0 0 0 K00133 0.6142857142857143 0.8319088319088319 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] path:map00260,path:map00261,path:map00270,path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Glycine, serine and threonine metabolism,Monobactam biosynthesis,Cysteine and methionine metabolism,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 185.0 534.0 524.0 3.0 0.976234003656307 E 223.0 324.0 1.0 1.0 COG0136 Aspartate-semialdehyde_dehydrogenase Asd 547.0 0.4076782449725777 0.5923217550274223 0.60418889068981 0.618844825864401 0.6115168582771056 0.014655935174591 0 1 0 1 K00134 0.3371428571428571 0.9772079772079773 GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] path:map00010,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map04066,path:map05010,path:map05130,path:map05132,path:map05415 Glycolysis / Gluconeogenesis,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,HIF-1 signaling pathway,Alzheimer disease,Pathogenic Escherichia coli infection,Salmonella infection,Diabetic cardiomyopathy 186.0 423.0 237.0 5.0 0.664050235478807 G 133.0 504.0 2.0 0.965463108320251 COG0057 Glyceraldehyde-3-phosphate_dehydrogenase/erythrose-4-phosphate_dehydrogenase GapA 637.0 0.2087912087912088 0.7912087912087912 0.0421260157565776 0.530740539504215 0.2864332776303963 0.4886145237476373 0 0 0 0 K00135 0.26 0.4472934472934473 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] path:map00250,path:map00310,path:map00350,path:map00650,path:map00760,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,Lysine degradation,Tyrosine metabolism,Butanoate metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 277.0 449.0 448.0 2.0 0.997777777777778 C 134.0 316.0 3.0 0.995555555555556 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 450.0 0.2977777777777777 0.7022222222222222 0.0559065249509646 0.572083608662042 0.3139950668065033 0.5161770837110774 0 0 0 0 K00137 0.0 0.037037037037037 prr; aminobutyraldehyde dehydrogenase [EC:1.2.1.19] path:map00310,path:map00330,path:map00410,path:map01100,path:map01120 Lysine degradation,Arginine and proline metabolism,beta-Alanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 468.0 16.0 0.0 1.0 1.0 C 0.0 16.0 2.0 0.9375 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 16.0 0.0 1.0 0.0583431130070218 0.0798103335348827 0.0690767232709522 0.0214672205278609 0 0 0 0 K00138 0.0057142857142857 0.2051282051282051 aldB; aldehyde dehydrogenase [EC:1.2.1.-] path:map00010,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 471.0 84.0 0.0 1.0 1.0 C 2.0 82.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 84.0 0.0238095238095238 0.9761904761904762 0.0497470877614741 0.0861118881195801 0.0679294879405271 0.0363648003581059 0 0 0 0 K00140 0.0971428571428571 0.3048433048433048 mmsA, iolA, ALDH6A1; malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] path:map00280,path:map00410,path:map00562,path:map00640,path:map01100,path:map01200 Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Inositol phosphate metabolism,Propanoate metabolism,Metabolic pathways,Carbon metabolism 411.0 180.0 175.0 2.0 0.972972972972973 C 39.0 146.0 2.0 0.972972972972973 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 185.0 0.2108108108108108 0.7891891891891892 0.0158402475308401 0.198306950082154 0.107073598806497 0.1824667025513139 0 0 0 0 K00141 0.0028571428571428 0.0341880341880341 xylC; benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28] path:map00622,path:map00623,path:map00627,path:map01100,path:map01120,path:map01220 Xylene degradation,Toluene degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 462.0 14.0 0.0 1.0 1.0 C 1.0 13.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 14.0 0.0714285714285714 0.9285714285714286 0.0682856035773266 0.0596335599162625 0.0639595817467945 0.0086520436610641 0 0 0 0 K00145 0.26 0.7207977207977208 argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 176.0 359.0 0.0 1.0 1.0 E 94.0 265.0 1.0 1.0 COG0002 N-acetyl-gamma-glutamylphosphate_reductase ArgC 359.0 0.2618384401114206 0.7381615598885793 0.602764162202645 0.629179638708381 0.615971900455513 0.026415476505736 0 1 0 1 K00146 0.0 0.1339031339031339 feaB, tynC; phenylacetaldehyde dehydrogenase [EC:1.2.1.39] path:map00350,path:map00360,path:map00643,path:map01100,path:map01120 Tyrosine metabolism,Phenylalanine metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 427.0 65.0 0.0 1.0 1.0 C 0.0 65.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 65.0 0.0 1.0 0.0767374044575563 0.63885242384554 0.3577949141515481 0.5621150193879837 0 0 0 0 K00147 0.14 0.6923076923076923 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] path:map00330,path:map00332,path:map01100,path:map01110,path:map01230 Arginine and proline metabolism,Carbapenem biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 342.0 301.0 297.0 3.0 0.97411003236246 E 49.0 260.0 1.0 1.0 COG0014 Gamma-glutamyl_phosphate_reductase ProA 309.0 0.1585760517799352 0.8414239482200647 0.284073673752069 0.361061537564448 0.3225676056582585 0.0769878638123789 0 0 0 0 K00148 0.0771428571428571 0.074074074074074 fdhA; glutathione-independent formaldehyde dehydrogenase [EC:1.2.1.46] path:map00625,path:map00680,path:map01100,path:map01120,path:map01200 Chloroalkane and chloroalkene degradation,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 332.0 53.0 41.0 2.0 0.815384615384615 E 31.0 34.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 65.0 0.4769230769230769 0.5230769230769231 0.0086498243576284 0.380041826501103 0.1943458254293657 0.3713920021434746 0 0 0 0 K00150 0.6228571428571429 0.1025641025641025 gap2; glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) [EC:1.2.1.59] path:map00010,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 236.0 256.0 251.0 4.0 0.951672862453531 G 231.0 38.0 2.0 0.981412639405204 COG0057 Glyceraldehyde-3-phosphate_dehydrogenase/erythrose-4-phosphate_dehydrogenase GapA 269.0 0.8587360594795539 0.1412639405204461 0.470212569887792 0.478633172140378 0.474422871014085 0.008420602252586 0 0 0 0 K00151 0.0085714285714285 0.0712250712250712 hpaE, hpcC; 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60] path:map00350,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 449.0 32.0 0.0 1.0 1.0 C 3.0 29.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 32.0 0.09375 0.90625 0.0920671735226663 0.155255496261594 0.1236613348921301 0.0631883227389276 0 0 0 0 K00152 0.0 0.0028490028490028 nahF; salicylaldehyde dehydrogenase [EC:1.2.1.65] path:map00626,path:map01100,path:map01120,path:map01220 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 483.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 1.0 0.0 1.0 0 0 0 0 K00153 0.0 0.0797720797720797 E1.1.1.306; S-(hydroxymethyl)mycothiol dehydrogenase [EC:1.1.1.306] 352.0 32.0 31.0 2.0 0.96969696969697 C 0.0 33.0 2.0 0.96969696969697 COG1062 Zn-dependent_alcohol/formaldehyde_dehydrogenase FrmA 33.0 0.0 1.0 0.0137940769068578 0.0260417120911585 0.0199178944990081 0.0122476351843007 0 0 0 0 K00154 0.0085714285714285 0.0911680911680911 E1.2.1.68; coniferyl-aldehyde dehydrogenase [EC:1.2.1.68] 384.0 37.0 0.0 1.0 1.0 C 3.0 34.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 37.0 0.081081081081081 0.918918918918919 0.0167020301868582 0.0514490801704727 0.0340755551786654 0.0347470499836145 0 0 0 0 K00156 0.0571428571428571 0.1396011396011396 poxB; pyruvate dehydrogenase (quinone) [EC:1.2.5.1] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 466.0 53.0 38.0 4.0 0.6625 EH 23.0 57.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 80.0 0.2875 0.7125 0.152853098341001 0.311948623072277 0.232400860706639 0.159095524731276 0 0 0 0 K00157 0.0 0.0056980056980056 AOX; aldehyde oxidase [EC:1.2.3.1] path:map00280,path:map00350,path:map00380,path:map00750,path:map00760,path:map00830,path:map00982,path:map01100,path:map01120,path:map04630 Valine, leucine and isoleucine degradation,Tyrosine metabolism,Tryptophan metabolism,Vitamin B6 metabolism,Nicotinate and nicotinamide metabolism,Retinol metabolism,Drug metabolism - cytochrome P450,Metabolic pathways,Microbial metabolism in diverse environments,JAK-STAT signaling pathway 65.0 1.0 0.0 2.0 0.5 C 0.0 2.0 1.0 1.0 COG4631 Xanthine_dehydrogenase,_molybdopterin-binding_subunit_XdhB XdhB 2.0 0.0 1.0 0 0 0 0 K00158 0.0657142857142857 0.1168091168091168 E1.2.3.3, poxL; pyruvate oxidase [EC:1.2.3.3] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 406.0 41.0 28.0 7.0 0.5125 EH 30.0 49.0 3.0 0.9375 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 79.0 0.379746835443038 0.620253164556962 0.0909299044002147 0.127886286883693 0.1094080956419538 0.0369563824834782 0 0 0 0 K00161 0.2885714285714286 0.5213675213675214 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] path:map00010,path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200,path:map04066,path:map04922,path:map05230,path:map05415 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,HIF-1 signaling pathway,Glucagon signaling pathway,Central carbon metabolism in cancer,Diabetic cardiomyopathy 184.0 443.0 0.0 1.0 1.0 C 169.0 274.0 3.0 0.968397291196388 COG1071 TPP-dependent_pyruvate_or_acetoin_dehydrogenase_subunit_alpha AcoA 443.0 0.3814898419864559 0.618510158013544 0.102650883360905 0.363396773783585 0.233023828572245 0.26074589042268 0 0 0 0 K00162 0.2885714285714286 0.5014245014245015 PDHB, pdhB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1] path:map00010,path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200,path:map04066,path:map04922,path:map05230,path:map05415 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,HIF-1 signaling pathway,Glucagon signaling pathway,Central carbon metabolism in cancer,Diabetic cardiomyopathy 231.0 401.0 0.0 1.0 1.0 C 129.0 272.0 3.0 0.932668329177057 COG0022 Pyruvate/2-oxoglutarate/acetoin_dehydrogenase_complex,_dehydrogenase_(E1)_component,_beta_subunit AcoB 401.0 0.3216957605985037 0.6783042394014963 0.219705002979573 0.713951977094643 0.4668284900371079 0.49424697411507 0 0 0 0 K00163 0.0371428571428571 0.2621082621082621 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1] path:map00010,path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 721.0 123.0 122.0 2.0 0.991935483870967 C 13.0 111.0 2.0 0.983870967741936 COG2609 Pyruvate_dehydrogenase_complex,_dehydrogenase_(E1)_component AceE 124.0 0.1048387096774193 0.8951612903225806 0.0270369023116287 0.172719704569598 0.0998783034406133 0.1456828022579693 0 0 0 0 K00164 0.0 0.4472934472934473 OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2] path:map00020,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 709.0 160.0 159.0 2.0 0.993788819875776 C 0.0 161.0 2.0 0.788819875776398 COG0567 2-oxoglutarate_dehydrogenase_complex,_dehydrogenase_(E1)_component,_and_related_enzymes SucA 161.0 0.0 1.0 0.0022749507314038 0.0059241581539834 0.0040995544426936 0.0036492074225796 0 0 0 0 K00166 0.0857142857142857 0.1994301994301994 BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4] path:map00280,path:map00640,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 214.0 118.0 0.0 1.0 1.0 C 32.0 86.0 2.0 0.991525423728814 COG1071 TPP-dependent_pyruvate_or_acetoin_dehydrogenase_subunit_alpha AcoA 118.0 0.2711864406779661 0.7288135593220338 0.0397745305726559 0.800694545494947 0.4202345380338014 0.7609200149222911 0 0 0 0 K00167 0.06 0.150997150997151 BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4] path:map00280,path:map00640,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 300.0 77.0 0.0 1.0 1.0 C 21.0 56.0 1.0 1.0 COG0022 Pyruvate/2-oxoglutarate/acetoin_dehydrogenase_complex,_dehydrogenase_(E1)_component,_beta_subunit AcoB 77.0 0.2727272727272727 0.7272727272727273 0.127188819251829 0.985208701083392 0.5561987601676105 0.858019881831563 0 0 0 0 K00169 0.6457142857142857 0.2108262108262108 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1] path:map00010,path:map00020,path:map00620,path:map00633,path:map00640,path:map00650,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Nitrotoluene degradation,Propanoate metabolism,Butanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 256.0 434.0 0.0 1.0 1.0 C 337.0 97.0 1.0 1.0 COG0674 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_alpha_subunit PorA 434.0 0.7764976958525346 0.2235023041474654 0.972938035241118 0.934932790225097 0.9539354127331074 0.0380052450160209 1 1 1 1 K00170 0.6314285714285715 0.1766381766381766 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1] path:map00010,path:map00020,path:map00620,path:map00633,path:map00640,path:map00650,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Nitrotoluene degradation,Propanoate metabolism,Butanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 197.0 426.0 0.0 1.0 1.0 C 339.0 87.0 3.0 0.990610328638498 COG1013 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_beta_subunit PorB 426.0 0.795774647887324 0.204225352112676 0.952597939147855 0.977125663522408 0.9648618013351316 0.024527724374553 1 1 1 1 K00171 0.4971428571428571 0.150997150997151 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1] path:map00010,path:map00020,path:map00620,path:map00633,path:map00640,path:map00650,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Nitrotoluene degradation,Propanoate metabolism,Butanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 49.0 322.0 0.0 1.0 1.0 C 256.0 66.0 3.0 0.962732919254658 COG1144 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_delta_subunit PorD 322.0 0.7950310559006211 0.2049689440993788 0.84396104870504 0.867031122205865 0.8554960854554525 0.023070073500825 1 1 1 1 K00172 0.5257142857142857 0.1937321937321937 porC, porG; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1] path:map00010,path:map00020,path:map00620,path:map00633,path:map00640,path:map00650,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Nitrotoluene degradation,Propanoate metabolism,Butanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 113.0 396.0 0.0 1.0 1.0 C 287.0 96.0 3.0 0.921717171717172 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 383.0 0.7493472584856397 0.2506527415143603 0.917166831037032 0.956360064580985 0.9367634478090086 0.0391932335439529 1 1 1 1 K00174 0.6628571428571428 0.5042735042735043 korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] path:map00010,path:map00020,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 196.0 684.0 0.0 1.0 1.0 C 351.0 332.0 1.0 1.0 COG0674 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_alpha_subunit PorA 683.0 0.513909224011713 0.486090775988287 0.288316762978368 0.8068425103764 0.547579636677384 0.518525747398032 0 0 0 0 K00175 0.6371428571428571 0.5014245014245015 korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] path:map00010,path:map00020,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 151.0 662.0 0.0 1.0 1.0 C 336.0 326.0 2.0 0.996978851963746 COG1013 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_beta_subunit PorB 662.0 0.5075528700906344 0.4924471299093655 0.887417006321601 0.880067586940735 0.883742296631168 0.007349419380866 1 1 1 1 K00176 0.2542857142857143 0.2649572649572649 korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] path:map00020,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 13.0 270.0 0.0 1.0 1.0 C 119.0 154.0 11.0 0.761904761904762 COG1146 NAD-dependent_dihydropyrimidine_dehydrogenase,_PreA_subunit PreA 273.0 0.4358974358974359 0.5641025641025641 0.916377691456956 0.855858659578991 0.8861181755179734 0.060519031877965 1 1 1 1 K00177 0.2114285714285714 0.2592592592592592 korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] path:map00020,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 119.0 253.0 0.0 1.0 1.0 C 106.0 147.0 2.0 0.972332015810277 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 253.0 0.4189723320158103 0.5810276679841897 0.247178361675612 0.636563134672059 0.4418707481738355 0.389384772996447 0 0 0 0 K00179 0.4 0.2962962962962963 iorA; indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.8] 292.0 388.0 0.0 1.0 1.0 C 240.0 142.0 4.0 0.90979381443299 COG4231 TPP-dependent_indolepyruvate_ferredoxin_oxidoreductase,_alpha_subunit IorA 382.0 0.6282722513089005 0.3717277486910995 0.63032864188566 0.644910833192047 0.6376197375388535 0.014582191306387 0 1 0 1 K00180 0.3771428571428571 0.245014245014245 iorB; indolepyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.8] 92.0 298.0 0.0 1.0 1.0 C 183.0 115.0 2.0 0.98993288590604 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 298.0 0.6140939597315436 0.3859060402684564 0.636643764903835 0.0902372124454167 0.3634404886746258 0.5464065524584183 0 1 0 1 K00183 0.0285714285714285 0.0028490028490028 791.0 15.0 0.0 1.0 1.0 C 14.0 1.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 15.0 0.9333333333333332 0.0666666666666666 0.06626493473309 0.131451109396422 0.098858022064756 0.0651861746633319 0 0 0 0 K00184 0.1314285714285714 0.282051282051282 dmsB; dimethyl sulfoxide reductase iron-sulfur subunit path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 122.0 236.0 0.0 1.0 1.0 C 85.0 151.0 4.0 0.817796610169492 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 236.0 0.3601694915254237 0.6398305084745762 0.310022729371424 0.942295010170858 0.626158869771141 0.6322722807994341 0 0 0 0 K00185 0.1057142857142857 0.245014245014245 dmsC; dimethyl sulfoxide reductase membrane subunit path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 227.0 187.0 186.0 2.0 0.99468085106383 C 63.0 125.0 4.0 0.957446808510638 COG5557 Ni/Fe-hydrogenase_2_integral_membrane_subunit_HybB HybB 188.0 0.3351063829787234 0.6648936170212766 0.111732845350689 0.0004738109444059 0.0561033281475474 0.1112590344062831 0 0 0 0 K00186 0.16 0.0769230769230769 vorA; 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 279.0 89.0 0.0 1.0 1.0 C 62.0 27.0 1.0 1.0 COG0674 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_alpha_subunit PorA 89.0 0.6966292134831461 0.3033707865168539 0.180354429234185 0.59652910741965 0.3884417683269175 0.416174678185465 0 0 0 0 K00187 0.1342857142857142 0.0769230769230769 vorB; 2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 239.0 93.0 0.0 1.0 1.0 C 60.0 33.0 2.0 0.645161290322581 COG1013 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_beta_subunit PorB 93.0 0.6451612903225806 0.3548387096774194 0.802530554870238 0.842555746347576 0.822543150608907 0.0400251914773379 1 1 1 1 K00188 0.1457142857142857 0.017094017094017 vorD; 2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 58.0 61.0 0.0 1.0 1.0 C 55.0 6.0 2.0 0.639344262295082 COG1144 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_delta_subunit PorD 61.0 0.9016393442622952 0.0983606557377049 0.548587046379708 0.555634763825671 0.5521109051026896 0.0070477174459629 0 1 0 1 K00189 0.1571428571428571 0.0056980056980056 vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] path:map00010,path:map00020,path:map00280,path:map00620,path:map00633,path:map00640,path:map00650,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Valine, leucine and isoleucine degradation,Pyruvate metabolism,Nitrotoluene degradation,Propanoate metabolism,Butanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 166.0 68.0 0.0 1.0 1.0 C 66.0 2.0 1.0 1.0 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 68.0 0.9705882352941176 0.0294117647058823 0.978693845074377 0.987526312744061 0.983110078909219 0.008832467669684 0 0 1 1 K00192 0.1971428571428571 0.0028490028490028 cdhA; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha [EC:1.2.7.4] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 315.0 106.0 0.0 1.0 1.0 C 105.0 1.0 3.0 0.849056603773585 COG1152 CO_dehydrogenase/acetyl-CoA_synthase_alpha_subunit CdhA 106.0 0.9905660377358492 0.0094339622641509 0.954878111771791 0.977663087463895 0.966270599617843 0.0227849756921039 0 0 1 1 K00193 0.1942857142857142 0.0113960113960113 cdhC; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta [EC:2.3.1.169] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 393.0 88.0 0.0 1.0 1.0 C 84.0 4.0 2.0 0.931818181818182 COG1614 CO_dehydrogenase/acetyl-CoA_synthase_beta_subunit CdhC 88.0 0.9545454545454546 0.0454545454545454 0.912723004185009 0.986357026665252 0.9495400154251306 0.073634022480243 1 1 1 1 K00194 0.2057142857142857 0.0598290598290598 cdhD, acsD; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit delta [EC:2.1.1.245] path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 275.0 102.0 98.0 2.0 0.962264150943396 C 83.0 22.0 3.0 0.962264150943396 COG2069 CO_dehydrogenase/acetyl-CoA_synthase_delta_subunit_(corrinoid_Fe-S_protein) CdhD 105.0 0.7904761904761904 0.2095238095238095 0.658481801098956 0.984411919387378 0.821446860243167 0.325930118288422 0 1 0 1 K00195 0.1742857142857143 0.0056980056980056 cdhB; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit epsilon path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 133.0 69.0 66.0 2.0 0.958333333333333 C 70.0 2.0 2.0 0.958333333333333 COG1880 CO_dehydrogenase/acetyl-CoA_synthase_epsilon_subunit CdhB 72.0 0.9722222222222222 0.0277777777777777 0.904038416018632 0.984679367112601 0.9443588915656164 0.0806409510939689 0 0 1 1 K00196 0.1257142857142857 0.1054131054131054 cooF; anaerobic carbon-monoxide dehydrogenase iron sulfur subunit path:map00633,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Nitrotoluene degradation,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 81.0 97.0 0.0 1.0 1.0 C 56.0 41.0 2.0 0.670103092783505 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 97.0 0.5773195876288659 0.422680412371134 0.917234287404556 0.933031336823477 0.9251328121140164 0.015797049418921 1 1 1 1 K00197 0.2257142857142857 0.0997150997150997 cdhE, acsC; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit gamma [EC:2.1.1.245] path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 352.0 106.0 80.0 3.0 0.773722627737226 C 94.0 43.0 4.0 0.934306569343066 COG1456 CO_dehydrogenase/acetyl-CoA_synthase_gamma_subunit_(corrinoid_Fe-S_protein) CdhE 137.0 0.6861313868613139 0.3138686131386861 0.894253253700089 0.98526215467396 0.9397577041870244 0.0910089009738709 1 1 1 1 K00198 0.1257142857142857 0.0911680911680911 cooS, acsA; anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4] path:map00633,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Nitrotoluene degradation,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 545.0 107.0 91.0 2.0 0.869918699186992 C 57.0 66.0 3.0 0.691056910569106 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 123.0 0.4634146341463415 0.5365853658536586 0.52179499693696 0.883184170861114 0.702489583899037 0.361389173924154 0 1 0 1 K00200 0.24 0.037037037037037 fwdA, fmdA; formylmethanofuran dehydrogenase subunit A [EC:1.2.7.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 461.0 124.0 0.0 1.0 1.0 C 111.0 13.0 2.0 0.991935483870968 COG1229 Formylmethanofuran_dehydrogenase_subunit_A FwdA 124.0 0.8951612903225806 0.1048387096774193 0.814752730261189 0.962566812932598 0.8886597715968936 0.147814082671409 1 1 1 1 K00201 0.2428571428571428 0.0341880341880341 fwdB, fmdB; formylmethanofuran dehydrogenase subunit B [EC:1.2.7.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 352.0 174.0 0.0 1.0 1.0 C 165.0 14.0 1.0 1.0 COG1029 Formylmethanofuran_dehydrogenase_subunit_B FwdB 179.0 0.9217877094972068 0.0782122905027933 0.362808782312027 0.777661296756863 0.570235039534445 0.414852514444836 0 0 0 0 K00202 0.1885714285714285 0.0227920227920227 fwdC, fmdC; formylmethanofuran dehydrogenase subunit C [EC:1.2.7.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 209.0 120.0 0.0 1.0 1.0 C 112.0 8.0 2.0 0.933333333333333 COG2218 Formylmethanofuran_dehydrogenase_subunit_C FwdC 120.0 0.9333333333333332 0.0666666666666666 0.78855764709816 0.933908242282272 0.861232944690216 0.1453505951841119 1 1 1 1 K00203 0.2142857142857142 0.0056980056980056 fwdD, fmdD; formylmethanofuran dehydrogenase subunit D [EC:1.2.7.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 94.0 126.0 0.0 1.0 1.0 C 124.0 2.0 1.0 1.0 COG1153 Formylmethanofuran_dehydrogenase_subunit_D FwdD 126.0 0.984126984126984 0.0158730158730158 0.896426972614678 0.860615212888 0.8785210927513389 0.0358117597266779 0 0 1 1 K00204 0.0285714285714285 0.0 fwdH; 4Fe-4S ferredoxin path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 139.0 11.0 0.0 1.0 1.0 C 11.0 0.0 1.0 1.0 COG1146 NAD-dependent_dihydropyrimidine_dehydrogenase,_PreA_subunit PreA 11.0 1.0 0.0 0.0017339214481937 0.0026993840357325 0.0022166527419631 0.0009654625875387 0 0 0 0 K00205 0.1971428571428571 0.0313390313390313 fwdF, fmdF; 4Fe-4S ferredoxin path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 102.0 113.0 0.0 1.0 1.0 C 102.0 11.0 5.0 0.876106194690266 COG1145 Ferredoxin NapF 113.0 0.9026548672566372 0.0973451327433628 0.666874701020053 0.766567973458902 0.7167213372394775 0.099693272438849 0 1 0 1 K00207 0.0 0.0085470085470085 DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] path:map00240,path:map00410,path:map00770,path:map00983,path:map01100 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Drug metabolism - other enzymes,Metabolic pathways 516.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG0167 Dihydroorotate_dehydrogenase PyrD 3.0 0.0 1.0 0 0 0 0 K00208 0.0257142857142857 0.5384615384615384 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] path:map00061,path:map00333,path:map00780,path:map01100,path:map01110,path:map01212,path:map01240 Fatty acid biosynthesis,Prodigiosin biosynthesis,Biotin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism,Biosynthesis of cofactors 210.0 244.0 243.0 2.0 0.995918367346939 I 9.0 236.0 2.0 0.995918367346939 COG0623 Enoyl-[acyl-carrier-protein]_reductase_FabI FabI 245.0 0.036734693877551 0.963265306122449 0.0015608918131621 0.0049566065395576 0.0032587491763598 0.0033957147263954 0 0 0 0 K00209 0.0028571428571428 0.0655270655270655 fabV, ter; enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44] path:map00061,path:map00650,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 371.0 24.0 0.0 1.0 1.0 I 1.0 23.0 1.0 1.0 COG3007 Trans-2-enoyl-CoA_reductase 24.0 0.0416666666666666 0.9583333333333334 0.341480494056999 0.217234780542914 0.2793576372999565 0.1242457135140849 0 0 0 0 K00210 0.0342857142857142 0.2364672364672364 124.0 89.0 77.0 2.0 0.881188118811881 E 12.0 89.0 2.0 0.891089108910891 COG0287 Prephenate_dehydrogenase TyrA 101.0 0.1188118811881188 0.8811881188118812 0.655292461278358 0.90444896750315 0.779870714390754 0.2491565062247919 0 1 0 1 K00211 0.0 0.017094017094017 TYR1; prephenate dehydrogenase (NADP+) [EC:1.3.1.13] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 271.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG0287 Prephenate_dehydrogenase TyrA 6.0 0.0 1.0 0.882957875415488 0.278642749686194 0.580800312550841 0.604315125729294 0 0 1 1 K00213 0.0114285714285714 0.0085470085470085 DHCR7; 7-dehydrocholesterol reductase [EC:1.3.1.21] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 243.0 5.0 2.0 2.0 0.625 C 5.0 3.0 2.0 0.625 COG1413 HEAT_repeat HEAT 8.0 0.625 0.375 0.16723177787746 0.34993609275537 0.258583935316415 0.18270431487791 0 0 0 0 K00214 0.0 0.0427350427350427 BLVRA, bvdR; biliverdin reductase [EC:1.3.1.24] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 317.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 15.0 0.0 1.0 0.0003098060820684 0.0038956105969925 0.0021027083395304 0.0035858045149241 0 0 0 0 K00215 0.3628571428571429 0.8005698005698005 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] path:map00261,path:map00300,path:map01100,path:map01110,path:map01120,path:map01230 Monobactam biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 138.0 419.0 415.0 4.0 0.983568075117371 E 129.0 297.0 4.0 0.990610328638498 COG0289 4-hydroxy-tetrahydrodipicolinate_reductase DapB 426.0 0.3028169014084507 0.6971830985915493 0.0701743771987551 0.432301798505552 0.2512380878521535 0.3621274213067968 0 0 0 0 K00216 0.0057142857142857 0.0541310541310541 entA; 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [EC:1.3.1.28] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 232.0 24.0 22.0 2.0 0.923076923076923 IQ 2.0 24.0 2.0 0.923076923076923 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 26.0 0.0769230769230769 0.9230769230769232 0.0297696272863232 0.0398523287468507 0.0348109780165869 0.0100827014605274 0 0 0 0 K00217 0.0114285714285714 0.0256410256410256 E1.3.1.32; maleylacetate reductase [EC:1.3.1.32] path:map00361,path:map00362,path:map00364,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Fluorobenzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 303.0 16.0 0.0 1.0 1.0 C 5.0 11.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 16.0 0.3125 0.6875 0.0230088540481862 0.66897558291653 0.3459922184823581 0.6459667288683438 0 0 0 0 K00218 0.0 0.0826210826210826 por; protochlorophyllide reductase [EC:1.3.1.33] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 232.0 31.0 29.0 3.0 0.911764705882353 IQ 0.0 34.0 2.0 0.882352941176471 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 34.0 0.0 1.0 0.0021041188878088 0.0120341224188185 0.0070691206533136 0.0099300035310097 0 0 0 0 K00219 0.0742857142857142 0.1937321937321937 fadH; 2,4-dienoyl-CoA reductase (NADPH2) [EC:1.3.1.34] 207.0 118.0 109.0 5.0 0.874074074074074 C 29.0 106.0 7.0 0.607407407407407 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 135.0 0.2148148148148148 0.7851851851851852 0.0096772131352841 0.0428252878811834 0.0262512505082337 0.0331480747458993 0 0 0 0 K00220 0.0 0.1623931623931624 tyrC; cyclohexadieny/prephenate dehydrogenase [EC:1.3.1.43 1.3.1.12] path:map00400,path:map00401,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 236.0 61.0 59.0 2.0 0.968253968253968 E 0.0 61.0 2.0 0.857142857142857 COG0287 Prephenate_dehydrogenase TyrA 61.0 0.0 1.0 0.97394658259301 0.0405053533156938 0.5072259679543519 0.9334412292773162 0 0 1 1 K00221 0.0114285714285714 0.017094017094017 E4.99.1.2; alkylmercury lyase [EC:4.99.1.2] 147.0 9.0 5.0 2.0 0.692307692307692 C 7.0 6.0 2.0 0.692307692307692 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 13.0 0.5384615384615384 0.4615384615384615 0.0312309841769653 0.073085021087563 0.0521580026322641 0.0418540369105977 0 0 0 0 K00222 0.0085714285714285 0.0056980056980056 TM7SF2, ERG24; Delta14-sterol reductase [EC:1.3.1.70] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 301.0 5.0 4.0 2.0 0.833333333333333 C 4.0 2.0 2.0 0.833333333333333 COG1413 HEAT_repeat HEAT 6.0 0.6666666666666666 0.3333333333333333 0.154569917087699 0.280500962136489 0.2175354396120939 0.12593104504879 0 0 0 0 K00223 0.0028571428571428 0.0028490028490028 ERG4; Delta24(24(1))-sterol reductase [EC:1.3.1.71] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 235.0 2.0 0.0 1.0 1.0 O 1.0 1.0 1.0 1.0 COG2020 Protein-S-isoprenylcysteine_O-methyltransferase_Ste14 STE14 2.0 0.5 0.5 0 0 0 0 K00226 0.1914285714285714 0.3561253561253561 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 101.0 201.0 183.0 4.0 0.909502262443439 F 70.0 150.0 4.0 0.968325791855204 COG0167 Dihydroorotate_dehydrogenase PyrD 220.0 0.3181818181818182 0.6818181818181818 0.295928207368907 0.872589913526378 0.5842590604476425 0.576661706157471 0 0 0 0 K00227 0.0 0.0 SC5DL, ERG3; Delta7-sterol 5-desaturase [EC:1.14.19.20] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 4.0 0.0 1.0 1.0 I 0.0 0.0 1.0 1.0 COG3000 Sterol_desaturase/sphingolipid_hydroxylase,_fatty_acid_hydroxylase_superfamily ERG3 0.0 0 0 0 0 K00228 0.0114285714285714 0.2706552706552707 CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 215.0 103.0 0.0 1.0 1.0 H 5.0 98.0 1.0 1.0 COG0408 Coproporphyrinogen-III_oxidase_HemH,_oxygen-dependent HemF 103.0 0.0485436893203883 0.9514563106796116 0.0051753071297578 0.0135622845978134 0.0093687958637856 0.0083869774680556 0 0 0 0 K00230 0.1685714285714285 0.0911680911680911 hemG; menaquinone-dependent protoporphyrinogen oxidase [EC:1.3.5.3] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 66.0 62.0 9.0 4.0 0.52991452991453 C 73.0 44.0 2.0 0.991452991452992 COG4635 Protoporphyrinogen_IX_oxidase,_menaquinone-dependent_(flavodoxin_domain) HemG 117.0 0.6239316239316239 0.376068376068376 0.228718603916702 0.526163439995506 0.3774410219561039 0.2974448360788039 0 0 0 0 K00231 0.0771428571428571 0.2934472934472934 PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 192.0 147.0 145.0 4.0 0.973509933774834 H 31.0 120.0 2.0 0.980132450331126 COG1232 Protoporphyrinogen_oxidase_HemY/PPOX HemY 151.0 0.2052980132450331 0.7947019867549668 0.0766086530028268 0.933393199337459 0.5050009261701429 0.8567845463346322 0 0 0 0 K00232 0.0 0.0655270655270655 E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase [EC:1.3.3.6] path:map00071,path:map00410,path:map00592,path:map00640,path:map01040,path:map01100,path:map01110,path:map01200,path:map01212,path:map03320,path:map04024,path:map04146,path:map04936 Fatty acid degradation,beta-Alanine metabolism,alpha-Linolenic acid metabolism,Propanoate metabolism,Biosynthesis of unsaturated fatty acids,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism,Fatty acid metabolism,PPAR signaling pathway,cAMP signaling pathway,Peroxisome,Alcoholic liver disease 567.0 24.0 23.0 2.0 0.96 I 0.0 25.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 25.0 0.0 1.0 0.0018923897419602 0.0114880954757123 0.0066902426088362 0.0095957057337521 0 0 0 0 K00239 0.4714285714285714 0.6866096866096866 sdhA, frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map05134 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Legionellosis 291.0 529.0 521.0 2.0 0.985102420856611 C 220.0 317.0 2.0 0.981378026070764 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 537.0 0.409683426443203 0.590316573556797 0.886725962921048 0.870889827408329 0.8788078951646885 0.015836135512719 1 1 1 1 K00240 0.4085714285714286 0.6524216524216524 sdhB, frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 100.0 453.0 0.0 1.0 1.0 C 160.0 293.0 3.0 0.966887417218543 COG0479 Succinate_dehydrogenase/fumarate_reductase,_Fe-S_protein_subunit SdhB/FrdB 453.0 0.3532008830022075 0.6467991169977925 0.181089384953597 0.307846679326893 0.244468032140245 0.126757294373296 0 0 0 0 K00241 0.3714285714285714 0.5897435897435898 sdhC, frdC; succinate dehydrogenase cytochrome b subunit path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 22.0 329.0 292.0 2.0 0.898907103825137 C 147.0 234.0 4.0 0.553805774278215 COG2009 Succinate_dehydrogenase/fumarate_reductase,_cytochrome_b_subunit SdhC 381.0 0.3858267716535433 0.6141732283464567 0.0032376472343192 0.0014620389741573 0.0023498431042382 0.0017756082601619 0 0 0 0 K00242 0.24 0.2592592592592592 sdhD, frdD; succinate dehydrogenase membrane anchor subunit path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 63.0 192.0 0.0 1.0 1.0 C 100.0 92.0 2.0 0.916666666666667 COG2142 Succinate_dehydrogenase,_hydrophobic_anchor_subunit SdhD 192.0 0.5208333333333334 0.4791666666666667 0.0316725108001052 0.511922413560141 0.2717974621801231 0.4802499027600358 0 0 0 0 K00243 0.0 0.1965811965811965 K00243; uncharacterized protein 207.0 68.0 65.0 2.0 0.957746478873239 S 0.0 71.0 1.0 1.0 COG2996 Predicted_RNA-binding_protein_YitL,_contains_S1_domains,_virulence_factor_B_family CvfB 71.0 0.0 1.0 0.0026444971152136 0.0210891392243469 0.0118668181697802 0.0184446421091332 0 0 0 0 K00244 0.04 0.1994301994301994 frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] path:map00020,path:map00190,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map02020 Citrate cycle (TCA cycle),Oxidative phosphorylation,Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Two-component system 126.0 114.0 97.0 4.0 0.844444444444444 C 16.0 118.0 7.0 0.792592592592593 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 134.0 0.1194029850746268 0.8805970149253731 0.0499016877537355 0.0376787780024326 0.043790232878084 0.0122229097513028 0 0 0 0 K00245 0.0114285714285714 0.1111111111111111 frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] path:map00020,path:map00190,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map02020 Citrate cycle (TCA cycle),Oxidative phosphorylation,Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Two-component system 162.0 50.0 0.0 1.0 1.0 C 4.0 46.0 1.0 1.0 COG0479 Succinate_dehydrogenase/fumarate_reductase,_Fe-S_protein_subunit SdhB/FrdB 50.0 0.08 0.92 0.0472136632736613 0.0338845114872908 0.040549087380476 0.0133291517863705 0 0 0 0 K00246 0.0028571428571428 0.0769230769230769 frdC; succinate dehydrogenase subunit C path:map00020,path:map00190,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map02020 Citrate cycle (TCA cycle),Oxidative phosphorylation,Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Two-component system 55.0 29.0 0.0 1.0 1.0 C 1.0 28.0 3.0 0.379310344827586 COG2009 Succinate_dehydrogenase/fumarate_reductase,_cytochrome_b_subunit SdhC 29.0 0.0344827586206896 0.9655172413793104 0.0384395413711314 0.0794440480035875 0.0589417946873594 0.0410045066324561 0 0 0 0 K00247 0.0 0.0598290598290598 frdD; succinate dehydrogenase subunit D path:map00020,path:map00190,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map02020 Citrate cycle (TCA cycle),Oxidative phosphorylation,Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Two-component system 78.0 21.0 0.0 1.0 1.0 C 0.0 21.0 2.0 0.619047619047619 COG2009 Succinate_dehydrogenase/fumarate_reductase,_cytochrome_b_subunit SdhC 21.0 0.0 1.0 0.045169291174843 0.242796893065456 0.1439830921201494 0.1976276018906129 0 0 0 0 K00248 0.18 0.376068376068376 ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1] path:map00071,path:map00280,path:map00410,path:map00640,path:map00650,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 187.0 263.0 171.0 3.0 0.73876404494382 I 110.0 246.0 3.0 0.99438202247191 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 356.0 0.3089887640449438 0.6910112359550562 0.307929232594302 0.87426353108337 0.591096381838836 0.566334298489068 0 0 0 0 K00249 0.3428571428571428 0.3048433048433048 ACADM, acd; acyl-CoA dehydrogenase [EC:1.3.8.7] path:map00071,path:map00280,path:map01100,path:map01110,path:map01212,path:map03320,path:map04936 Fatty acid degradation,Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism,PPAR signaling pathway,Alcoholic liver disease 70.0 625.0 486.0 3.0 0.816993464052288 I 317.0 446.0 3.0 0.994771241830065 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 763.0 0.4154652686762778 0.5845347313237221 0 0 0 0 K00252 0.1685714285714285 0.2962962962962963 GCDH, gcdH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] path:map00071,path:map00310,path:map00362,path:map00380,path:map01100,path:map01110,path:map01120 Fatty acid degradation,Lysine degradation,Benzoate degradation,Tryptophan metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 348.0 171.0 140.0 3.0 0.842364532019704 I 62.0 141.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 203.0 0.3054187192118227 0.6945812807881774 0.0040489682048131 0.0482415934393003 0.0261452808220566 0.0441926252344872 0 0 0 0 K00253 0.1057142857142857 0.1452991452991453 IVD, ivd; isovaleryl-CoA dehydrogenase [EC:1.3.8.4] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 352.0 57.0 21.0 3.0 0.606382978723404 I 41.0 53.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 94.0 0.4361702127659574 0.5638297872340425 0.023852928475276 0.200250711010186 0.112051819742731 0.1763977825349099 0 0 0 0 K00254 0.3085714285714285 0.5441595441595442 DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 153.0 302.0 301.0 2.0 0.996699669966997 F 110.0 193.0 1.0 1.0 COG0167 Dihydroorotate_dehydrogenase PyrD 303.0 0.363036303630363 0.636963696369637 0.0352063107984306 0.821502398184645 0.4283543544915378 0.7862960873862144 0 0 0 0 K00255 0.0 0.0569800569800569 ACADL; long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8] path:map00071,path:map01100,path:map01212,path:map03320 Fatty acid degradation,Metabolic pathways,Fatty acid metabolism,PPAR signaling pathway 369.0 23.0 13.0 2.0 0.696969696969697 I 0.0 33.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 33.0 0.0 1.0 0.000857650658683 0.004226554747894 0.0025421027032885 0.0033689040892109 0 0 0 0 K00256 0.0 0.0227920227920227 134.0 9.0 0.0 1.0 1.0 C 0.0 9.0 2.0 0.666666666666667 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 9.0 0.0 1.0 0.0820338161607437 0.133920654498164 0.1079772353294538 0.0518868383374203 0 0 0 0 K00257 0.0 0.0341880341880341 mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-] 370.0 19.0 18.0 2.0 0.95 I 0.0 20.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 20.0 0.0 1.0 0.0012516246166825 0.0064752474377412 0.0038634360272118 0.0052236228210587 0 0 0 0 K00259 0.0314285714285714 0.5213675213675214 ald; alanine dehydrogenase [EC:1.4.1.1] path:map00250,path:map00430,path:map01100 Alanine, aspartate and glutamate metabolism,Taurine and hypotaurine metabolism,Metabolic pathways 314.0 129.0 30.0 2.0 0.56578947368421 C 11.0 217.0 2.0 0.995614035087719 COG0686 Alanine_dehydrogenase_(includes_sporulation_protein_SpoVN) Ald 228.0 0.0482456140350877 0.9517543859649122 0.734137716264443 0.63263865919623 0.6833881877303365 0.101499057068213 0 1 0 1 K00260 0.26 0.131054131054131 gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2] path:map00220,path:map00250,path:map00430,path:map00910,path:map01100,path:map01120 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Taurine and hypotaurine metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 314.0 114.0 60.0 2.0 0.678571428571429 E 111.0 57.0 1.0 1.0 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 168.0 0.6607142857142857 0.3392857142857143 0.667638288836879 0.959726549638995 0.813682419237937 0.2920882608021159 0 1 0 1 K00261 0.6371428571428571 0.49002849002849 GLUD1_2, gdhA; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] path:map00220,path:map00250,path:map00910,path:map01100,path:map01120,path:map01200,path:map04217,path:map04964 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Necroptosis,Proximal tubule bicarbonate reclamation 239.0 425.0 274.0 2.0 0.737847222222222 E 334.0 242.0 1.0 1.0 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 576.0 0.5798611111111112 0.4201388888888889 0.517781994244574 0.837815343102742 0.677798668673658 0.3200333488581679 0 1 0 1 K00262 0.5142857142857142 0.4985754985754986 E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] path:map00220,path:map00250,path:map00910,path:map01100,path:map01120 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 289.0 327.0 231.0 3.0 0.751724137931034 E 216.0 220.0 2.0 0.970183486238532 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 436.0 0.4954128440366973 0.5045871559633027 0.713143161799475 0.240536323270704 0.4768397425350895 0.472606838528771 0 1 0 1 K00263 0.0342857142857142 0.1766381766381766 E1.4.1.9; leucine dehydrogenase [EC:1.4.1.9] path:map00280,path:map00290,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 298.0 60.0 33.0 2.0 0.689655172413793 E 12.0 75.0 1.0 1.0 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 87.0 0.1379310344827586 0.8620689655172413 0.0204378714336164 0.849206423078504 0.4348221472560602 0.8287685516448876 0 0 0 0 K00265 0.1342857142857142 0.5783475783475783 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] path:map00250,path:map00910,path:map01100,path:map01110,path:map01120,path:map01230 Alanine, aspartate and glutamate metabolism,Nitrogen metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 1140.0 239.0 210.0 3.0 0.885185185185185 E 48.0 222.0 3.0 0.862962962962963 COG0067 Glutamate_synthase_domain_1 GltB1 270.0 0.1777777777777777 0.8222222222222222 0.0011798594595629 0.366093984587592 0.1836369220235774 0.3649141251280291 0 0 0 0 K00266 0.2914285714285714 0.6752136752136753 gltD; glutamate synthase (NADPH) small chain [EC:1.4.1.13] path:map00250,path:map00910,path:map01100,path:map01110,path:map01120,path:map01230 Alanine, aspartate and glutamate metabolism,Nitrogen metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 232.0 305.0 160.0 3.0 0.67032967032967 C 139.0 316.0 3.0 0.951648351648352 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 455.0 0.3054945054945055 0.6945054945054945 0.702604534927766 0.195583921907732 0.449094228417749 0.507020613020034 0 1 0 1 K00270 0.0028571428571428 0.017094017094017 pdh; phenylalanine dehydrogenase [EC:1.4.1.20] path:map00350,path:map00360,path:map00400,path:map01100,path:map01110 Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 339.0 8.0 0.0 1.0 1.0 E 1.0 7.0 1.0 1.0 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 8.0 0.125 0.875 0.0294301266080057 0.0810264152571115 0.0552282709325586 0.0515962886491058 0 0 0 0 K00271 0.0 0.037037037037037 vdh; valine dehydrogenase (NAD+) [EC:1.4.1.23] path:map00280,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites 353.0 14.0 0.0 1.0 1.0 E 0.0 14.0 1.0 1.0 COG0334 Glutamate_dehydrogenase/leucine_dehydrogenase GdhA 14.0 0.0 1.0 6.25394733438984e-05 0.0235732364648713 0.0118178879691075 0.0235106969915274 0 0 0 0 K00273 0.0257142857142857 0.0341880341880341 DAO, aao; D-amino-acid oxidase [EC:1.4.3.3] path:map00260,path:map00311,path:map00330,path:map00470,path:map01100,path:map01110,path:map04146 Glycine, serine and threonine metabolism,Penicillin and cephalosporin biosynthesis,Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Peroxisome 217.0 23.0 22.0 3.0 0.92 E 10.0 15.0 2.0 0.92 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 25.0 0.4 0.6 0.0048060640279858 0.0527370325088985 0.0287715482684421 0.0479309684809127 0 0 0 0 K00274 0.0257142857142857 0.2051282051282051 MAO, aofH; monoamine oxidase [EC:1.4.3.4] path:map00260,path:map00330,path:map00340,path:map00350,path:map00360,path:map00380,path:map00950,path:map00982,path:map01100,path:map01110,path:map04726,path:map04728,path:map05012,path:map05030,path:map05031,path:map05034 Glycine, serine and threonine metabolism,Arginine and proline metabolism,Histidine metabolism,Tyrosine metabolism,Phenylalanine metabolism,Tryptophan metabolism,Isoquinoline alkaloid biosynthesis,Drug metabolism - cytochrome P450,Metabolic pathways,Biosynthesis of secondary metabolites,Serotonergic synapse,Dopaminergic synapse,Parkinson disease,Cocaine addiction,Amphetamine addiction,Alcoholism 121.0 115.0 107.0 4.0 0.877862595419847 E 11.0 120.0 4.0 0.916030534351145 COG1231 Monoamine_oxidase YobN 131.0 0.0839694656488549 0.916030534351145 0.0111250943648017 0.0247703375412301 0.0179477159530159 0.0136452431764284 0 0 0 0 K00275 0.0228571428571428 0.4245014245014245 pdxH, PNPO; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5] path:map00750,path:map01100,path:map01120,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 114.0 163.0 136.0 5.0 0.819095477386935 H 8.0 191.0 5.0 0.829145728643216 COG0259 Pyridoxine/pyridoxamine_5'-phosphate_oxidase PdxH 199.0 0.0402010050251256 0.9597989949748744 0.0078923933795042 0.069073426138653 0.0384829097590786 0.0611810327591487 0 0 0 0 K00276 0.0114285714285714 0.0512820512820512 AOC3, AOC2, tynA; primary-amine oxidase [EC:1.4.3.21] path:map00260,path:map00350,path:map00360,path:map00410,path:map00950,path:map00960,path:map01100,path:map01110 Glycine, serine and threonine metabolism,Tyrosine metabolism,Phenylalanine metabolism,beta-Alanine metabolism,Isoquinoline alkaloid biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 510.0 29.0 27.0 2.0 0.935483870967742 Q 7.0 24.0 2.0 0.967741935483871 COG3733 Cu2+-containing_amine_oxidase TynA 31.0 0.2258064516129032 0.7741935483870968 0.0044256296939776 0.01367884564276 0.0090522376683687 0.0092532159487824 0 0 0 0 K00278 0.2371428571428571 0.6467236467236467 nadB; L-aspartate oxidase [EC:1.4.3.16] path:map00250,path:map00760,path:map01100,path:map01240 Alanine, aspartate and glutamate metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 256.0 324.0 255.0 2.0 0.824427480916031 H 95.0 298.0 3.0 0.776081424936387 COG0029 Aspartate_oxidase NadB 393.0 0.2417302798982188 0.7582697201017812 0.909314358199237 0.765741903844719 0.837528131021978 0.143572454354518 1 1 1 1 K00279 0.0028571428571428 0.0085470085470085 CKX; cytokinin dehydrogenase [EC:1.5.99.12] path:map00908,path:map01110 Zeatin biosynthesis,Biosynthesis of secondary metabolites 287.0 5.0 0.0 1.0 1.0 C 1.0 4.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 5.0 0.2 0.8 8.80071913333932e-12 0.0901164361255507 0.0450582180671757 0.0901164361167499 0 0 0 0 K00281 0.02 0.4843304843304843 GLDC, gcvP; glycine dehydrogenase [EC:1.4.4.2] path:map00260,path:map00630,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 415.0 181.0 177.0 2.0 0.978378378378378 E 7.0 178.0 2.0 0.762162162162162 COG0403 Glycine_cleavage_system_protein_P_(pyridoxal-binding),_N-terminal_domain GcvP1 185.0 0.0378378378378378 0.9621621621621622 0.0103709746090312 0.0662754096644481 0.0383231921367396 0.0559044350554169 0 0 0 0 K00282 0.38 0.3646723646723647 gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2] path:map00260,path:map00630,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 307.0 265.0 254.0 3.0 0.929824561403509 E 150.0 135.0 1.0 1.0 COG0403 Glycine_cleavage_system_protein_P_(pyridoxal-binding),_N-terminal_domain GcvP1 285.0 0.5263157894736842 0.4736842105263157 0.238783693034193 0.811616693662432 0.5252001933483126 0.572833000628239 0 0 0 0 K00283 0.3857142857142857 0.5925925925925926 gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2] path:map00260,path:map00630,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 365.0 364.0 360.0 2.0 0.989130434782608 E 148.0 220.0 2.0 0.766304347826087 COG1003 Glycine_cleavage_system_protein_P_(pyridoxal-binding),_C-terminal_domain GcvP2 368.0 0.4021739130434782 0.5978260869565217 0.978998353167522 0.964160256881394 0.971579305024458 0.014838096286128 1 1 1 1 K00284 0.0142857142857142 0.4017094017094017 GLU, gltS; glutamate synthase (ferredoxin) [EC:1.4.7.1] path:map00630,path:map00910,path:map01120 Glyoxylate and dicarboxylate metabolism,Nitrogen metabolism,Microbial metabolism in diverse environments 1158.0 154.0 143.0 3.0 0.927710843373494 E 5.0 161.0 2.0 0.891566265060241 COG0067 Glutamate_synthase_domain_1 GltB1 166.0 0.0301204819277108 0.9698795180722892 0.0748122231328684 0.348187270827815 0.2114997469803416 0.2733750476949466 0 0 0 0 K00285 0.0057142857142857 0.2307692307692307 dadA; D-amino-acid dehydrogenase [EC:1.4.5.1] path:map00360,path:map00470,path:map01100 Phenylalanine metabolism,D-Amino acid metabolism,Metabolic pathways 202.0 92.0 65.0 2.0 0.773109243697479 E 3.0 116.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 119.0 0.0252100840336134 0.9747899159663864 0.0151099018749552 0.0157220758333285 0.0154159888541418 0.0006121739583732 0 0 0 0 K00286 0.3285714285714285 0.8062678062678063 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] path:map00330,path:map01100,path:map01110,path:map01230 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 129.0 426.0 422.0 3.0 0.983833718244803 E 120.0 313.0 2.0 0.993071593533487 COG0345 Pyrroline-5-carboxylate_reductase ProC 433.0 0.277136258660508 0.7228637413394919 0.401181175725709 0.261902828609122 0.3315420021674155 0.139278347116587 0 0 0 0 K00287 0.2 0.5242165242165242 DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] path:map00670,path:map00790,path:map01100,path:map01240,path:map01523 One carbon pool by folate,Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Antifolate resistance 62.0 289.0 0.0 1.0 1.0 H 84.0 205.0 1.0 1.0 COG0262 Dihydrofolate_reductase FolA 289.0 0.2906574394463668 0.7093425605536332 0.0082625153565407 0.201570988042064 0.1049167516993023 0.1933084726855232 0 0 0 0 K00288 0.0 0.0284900284900284 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3] path:map00670,path:map01100,path:map01120,path:map01240 One carbon pool by folate,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 550.0 6.0 2.0 2.0 0.6 F 0.0 10.0 1.0 1.0 COG2759 Formyltetrahydrofolate_synthetase MIS1 10.0 0.0 1.0 0.882197207164752 0.334938308636523 0.6085677579006376 0.547258898528229 0 0 1 1 K00290 0.1257142857142857 0.2763532763532763 LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] path:map00300,path:map00310,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Lysine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 119.0 157.0 147.0 3.0 0.912790697674419 E 67.0 105.0 3.0 0.819767441860465 COG1748 Saccharopine_dehydrogenase,_NADP-dependent Lys9 172.0 0.3895348837209302 0.6104651162790697 0.280001556191048 0.532491218401655 0.4062463872963515 0.252489662210607 0 0 0 0 K00293 0.0285714285714285 0.0626780626780626 LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10] path:map00300,path:map00310,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Lysine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 401.0 33.0 32.0 2.0 0.970588235294117 E 11.0 23.0 1.0 1.0 COG1748 Saccharopine_dehydrogenase,_NADP-dependent Lys9 34.0 0.3235294117647059 0.6764705882352942 0.454696709281379 0.880276310209262 0.6674865097453205 0.425579600927883 0 0 0 0 K00294 0.1771428571428571 0.3048433048433048 E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88] path:map00250,path:map00330,path:map01100 Alanine, aspartate and glutamate metabolism,Arginine and proline metabolism,Metabolic pathways 374.0 184.0 0.0 1.0 1.0 C 66.0 118.0 2.0 0.972826086956522 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 184.0 0.358695652173913 0.6413043478260869 0.0117625296247392 0.828250188888908 0.4200063592568236 0.8164876592641688 0 0 0 0 K00297 0.1657142857142857 0.7293447293447294 metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] path:map00670,path:map00720,path:map01100,path:map01120,path:map01200 One carbon pool by folate,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 88.0 288.0 207.0 3.0 0.72 E 63.0 337.0 3.0 0.84 COG0685 5,10-methylenetetrahydrofolate_reductase MetF 400.0 0.1575 0.8425 0.0326792831718506 0.633512392930173 0.3330958380510118 0.6008331097583224 0 0 0 0 K00298 0.0 0.0085470085470085 ceo; N5-(carboxyethyl)ornithine synthase [EC:1.5.1.24] 291.0 2.0 0.0 2.0 0.5 E 0.0 4.0 1.0 1.0 COG0686 Alanine_dehydrogenase_(includes_sporulation_protein_SpoVN) Ald 4.0 0.0 1.0 5.71392573359232e-12 1.3950382367681598e-11 9.832154050636959e-12 8.236456634089278e-12 0 0 0 0 K00299 0.0514285714285714 0.168091168091168 ssuE, msuE; FMN reductase [EC:1.5.1.38] path:map00740,path:map00920,path:map01100 Riboflavin metabolism,Sulfur metabolism,Metabolic pathways 89.0 99.0 97.0 2.0 0.98019801980198 S 20.0 81.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 101.0 0.198019801980198 0.801980198019802 0.0241586279785722 0.143021063194787 0.0835898455866796 0.1188624352162148 0 0 0 0 K00301 0.0 0.0655270655270655 E1.5.3.1; sarcosine oxidase [EC:1.5.3.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 303.0 21.0 18.0 2.0 0.875 E 0.0 24.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 24.0 0.0 1.0 0.0261411579356628 0.519185557677246 0.2726633578064544 0.4930443997415831 0 0 0 0 K00302 0.1371428571428571 0.1481481481481481 soxA; sarcosine oxidase, subunit alpha [EC:1.5.3.24 1.5.3.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 185.0 89.0 50.0 5.0 0.589403973509934 C 62.0 87.0 6.0 0.470198675496689 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 149.0 0.4161073825503356 0.5838926174496645 0.723466928112478 0.669589381739668 0.696528154926073 0.05387754637281 0 1 0 1 K00303 0.2314285714285714 0.245014245014245 soxB; sarcosine oxidase, subunit beta [EC:1.5.3.24 1.5.3.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 137.0 237.0 226.0 3.0 0.951807228915663 E 114.0 135.0 3.0 0.991967871485944 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 249.0 0.4578313253012048 0.5421686746987951 0.0239501593283087 0.857351853664867 0.4406510064965878 0.8334016943365583 0 0 0 0 K00304 0.0 0.0883190883190883 soxD; sarcosine oxidase, subunit delta [EC:1.5.3.24 1.5.3.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 73.0 48.0 44.0 2.0 0.923076923076923 E 0.0 52.0 2.0 0.980769230769231 COG4311 Sarcosine_oxidase_delta_subunit SoxD 52.0 0.0 1.0 0.0050069707760166 0.0260615658011573 0.0155342682885869 0.0210545950251406 0 0 0 0 K00305 0.0 0.094017094017094 soxG; sarcosine oxidase, subunit gamma [EC:1.5.3.24 1.5.3.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 94.0 48.0 45.0 3.0 0.905660377358491 E 0.0 53.0 2.0 0.905660377358491 COG4583 Sarcosine_oxidase_gamma_subunit SoxG 53.0 0.0 1.0 0.0071759940822877 0.0334941297551895 0.0203350619187386 0.0263181356729018 0 0 0 0 K00306 0.0 0.0 PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7] path:map00260,path:map00310,path:map01100,path:map04146 Glycine, serine and threonine metabolism,Lysine degradation,Metabolic pathways,Peroxisome 3.0 0.0 1.0 1.0 E 0.0 0.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 0.0 0 0 0 0 K00311 0.3057142857142857 0.2051282051282051 ETFDH; electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1] 110.0 291.0 288.0 2.0 0.989795918367347 C 213.0 80.0 3.0 0.986394557823129 COG0644 Dehydrogenase_(flavoprotein) FixC 293.0 0.726962457337884 0.273037542662116 0.2268567135448 0.550547992595021 0.3887023530699104 0.323691279050221 0 0 0 0 K00313 0.2428571428571428 0.094017094017094 fixC; electron transfer flavoprotein-quinone oxidoreductase [EC:1.5.5.-] 230.0 156.0 0.0 1.0 1.0 C 116.0 39.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 155.0 0.7483870967741936 0.2516129032258064 0.0198530235715423 0.113584081424647 0.0667185524980946 0.0937310578531047 0 0 0 0 K00314 0.0 0.0028490028490028 SARDH; sarcosine dehydrogenase [EC:1.5.8.3] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 853.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 1.0 0.0 1.0 0 0 0 0 K00315 0.0 0.0427350427350427 DMGDH; dimethylglycine dehydrogenase [EC:1.5.8.4] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 759.0 26.0 22.0 3.0 0.8125 E 0.0 32.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 32.0 0.0 1.0 0.0061097257899444 0.0144193603292922 0.0102645430596183 0.0083096345393478 0 0 0 0 K00316 0.0 0.0142450142450142 spdH; spermidine dehydrogenase [EC:1.5.99.6] path:map00330,path:map00410,path:map01100 Arginine and proline metabolism,beta-Alanine metabolism,Metabolic pathways 455.0 5.0 3.0 2.0 0.714285714285714 E 0.0 7.0 3.0 0.428571428571429 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 7.0 0.0 1.0 5.7332095637939e-12 0.0703028715175832 0.0351514357616582 0.07030287151185 0 0 0 0 K00317 0.0028571428571428 0.0313390313390313 dmd-tmd; dimethylamine/trimethylamine dehydrogenase [EC:1.5.8.1 1.5.8.2] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 357.0 16.0 15.0 2.0 0.941176470588235 C 1.0 16.0 4.0 0.529411764705882 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 17.0 0.0588235294117647 0.9411764705882352 0.0304274069352678 0.0629367564790363 0.046682081707152 0.0325093495437684 0 0 0 0 K00318 0.2057142857142857 0.2393162393162393 PRODH, fadM, putB; proline dehydrogenase [EC:1.5.5.2] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 168.0 163.0 145.0 2.0 0.900552486187845 E 89.0 92.0 1.0 1.0 COG0506 Proline_dehydrogenase PutA 181.0 0.4917127071823204 0.5082872928176796 0.0609069671017413 0.281782015788125 0.1713444914449331 0.2208750486863837 0 0 0 0 K00319 0.2028571428571428 0.0 mtd; methylenetetrahydromethanopterin dehydrogenase [EC:1.5.98.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 262.0 72.0 0.0 1.0 1.0 C 72.0 0.0 1.0 1.0 COG1927 F420-dependent_methylenetetrahydromethanopterin_dehydrogenase Mtd 72.0 1.0 0.0 0.0115973891950674 0.0200671000052735 0.0158322446001704 0.0084697108102061 0 0 0 0 K00320 0.3457142857142857 0.0427350427350427 mer; 5,10-methylenetetrahydromethanopterin reductase [EC:1.5.98.2] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 178.0 200.0 0.0 1.0 1.0 C 174.0 26.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 200.0 0.87 0.13 0.873344819943122 0.910546757525507 0.8919457887343145 0.0372019375823849 1 1 1 1 K00322 0.0 0.1139601139601139 sthA, udhA; NAD(P) transhydrogenase [EC:1.6.1.1] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 403.0 49.0 0.0 1.0 1.0 C 0.0 49.0 2.0 0.959183673469388 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 49.0 0.0 1.0 0.0253231627786779 0.111845138569789 0.0685841506742334 0.0865219757911111 0 0 0 0 K00324 0.0657142857142857 0.3703703703703703 pntA; H+-translocating NAD(P) transhydrogenase subunit alpha [EC:1.6.1.2 7.1.1.1] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 37.0 282.0 280.0 2.0 0.992957746478873 C 43.0 241.0 2.0 0.975352112676056 COG3288 NAD/NADP_transhydrogenase_alpha_subunit PntA 284.0 0.1514084507042253 0.8485915492957746 0.0171130011205362 0.097481165544831 0.0572970833326835 0.0803681644242948 0 0 0 0 K00325 0.0628571428571428 0.3675213675213675 pntB; H+-translocating NAD(P) transhydrogenase subunit beta [EC:1.6.1.2 7.1.1.1] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 402.0 163.0 0.0 1.0 1.0 C 22.0 141.0 1.0 1.0 COG1282 NAD/NADP_transhydrogenase_beta_subunit PntB 163.0 0.1349693251533742 0.8650306748466258 0.0166060327296215 0.168726994969785 0.0926665138497032 0.1521209622401635 0 0 0 0 K00326 0.0714285714285714 0.0056980056980056 CYB5R; cytochrome-b5 reductase [EC:1.6.2.2] path:map00520 Amino sugar and nucleotide sugar metabolism 202.0 27.0 0.0 1.0 1.0 C 25.0 2.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 27.0 0.925925925925926 0.074074074074074 0.0069185763286097 0.0129070636382466 0.0099128199834281 0.0059884873096368 0 0 0 0 K00327 0.0028571428571428 0.0 POR; NADPH-ferrihemoprotein reductase [EC:1.6.2.4] 713.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 1.0 1.0 0.0 0 0 0 0 K00329 0.2171428571428571 0.2478632478632478 104.0 102.0 27.0 5.0 0.51 GM 79.0 121.0 3.0 0.85 COG0702 Uncharacterized_conserved_protein_YbjT,_contains_NAD(P)-binding_and_DUF2867_domains YbjT 200.0 0.395 0.605 0.0027163430752928 0.0032310166356835 0.0029736798554881 0.0005146735603906 0 0 0 0 K00330 0.4171428571428571 0.5299145299145299 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 56.0 395.0 0.0 1.0 1.0 C 152.0 243.0 1.0 1.0 COG0838 NADH:ubiquinone_oxidoreductase_subunit_3_(chain_A) NuoA 395.0 0.3848101265822785 0.6151898734177215 0.100648642158337 0.875966310839931 0.488307476499134 0.775317668681594 0 0 0 0 K00331 0.4914285714285714 0.5413105413105413 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 100.0 446.0 0.0 1.0 1.0 C 194.0 252.0 3.0 0.934977578475336 COG0377 NADH:ubiquinone_oxidoreductase_20_kD_subunit_(chain_B)_or_related_Fe-S_oxidoreductase NuoB 446.0 0.4349775784753363 0.5650224215246636 0.157005205164952 0.783782221181355 0.4703937131731535 0.626777016016403 0 0 0 0 K00332 0.3628571428571429 0.5042735042735043 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 51.0 355.0 0.0 1.0 1.0 C 136.0 219.0 1.0 1.0 COG0852 NADH:ubiquinone_oxidoreductase_27_kD_subunit_(chain_C) NuoC 355.0 0.3830985915492957 0.6169014084507042 0.162625206644813 0.240383230945295 0.201504218795054 0.077758024300482 0 0 0 0 K00333 0.4314285714285714 0.5356125356125356 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 238.0 431.0 0.0 1.0 1.0 C 186.0 245.0 5.0 0.85614849187935 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 431.0 0.4315545243619489 0.568445475638051 0.929052463849838 0.962978111248832 0.9460152875493352 0.033925647398994 1 1 1 1 K00334 0.0771428571428571 0.5783475783475783 nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 58.0 344.0 336.0 2.0 0.977272727272727 C 30.0 322.0 5.0 0.928977272727273 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 352.0 0.0852272727272727 0.9147727272727272 0.292918648729151 0.759823404370948 0.5263710265500495 0.4669047556417969 0 0 0 0 K00335 0.1657142857142857 0.6011396011396012 nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 263.0 452.0 0.0 1.0 1.0 C 75.0 377.0 10.0 0.88716814159292 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 452.0 0.165929203539823 0.834070796460177 0.898042623871881 0.851331674948256 0.8746871494100685 0.046710948923625 1 1 1 1 K00336 0.0457142857142857 0.5754985754985755 nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 187.0 286.0 0.0 1.0 1.0 C 18.0 267.0 5.0 0.479020979020979 COG1034 NADH_dehydrogenase/NADH:ubiquinone_oxidoreductase_75_kD_subunit_(chain_G) NuoG 285.0 0.0631578947368421 0.936842105263158 0.249308464532687 0.951171145174555 0.600239804853621 0.701862680641868 0 0 0 0 K00337 0.6 0.5555555555555556 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 186.0 511.0 510.0 3.0 0.996101364522417 C 251.0 262.0 4.0 0.951267056530214 COG1005 NADH:ubiquinone_oxidoreductase_subunit_1_(chain_H) NuoH 513.0 0.4892787524366471 0.5107212475633528 0.30205926802915 0.987843830023874 0.644951549026512 0.685784561994724 0 0 0 0 K00338 0.4771428571428571 0.5242165242165242 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 33.0 434.0 0.0 1.0 1.0 C 191.0 242.0 4.0 0.944700460829493 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 433.0 0.441108545034642 0.558891454965358 0.0017938523673914 0.217050526027418 0.1094221891974047 0.2152566736600266 0 0 0 0 K00339 0.4 0.5356125356125356 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 65.0 391.0 0.0 1.0 1.0 C 190.0 242.0 4.0 0.902777777777778 COG0839 NADH:ubiquinone_oxidoreductase_subunit_6_(chain_J) NuoJ 432.0 0.4398148148148148 0.5601851851851852 0.0658465986482452 0.853270288349762 0.4595584434990036 0.7874236897015169 0 0 0 0 K00340 0.4514285714285714 0.5327635327635327 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 77.0 385.0 368.0 3.0 0.950617283950617 C 162.0 245.0 6.0 0.938574938574939 COG0713 NADH:ubiquinone_oxidoreductase_subunit_11_or_4L_(chain_K) NuoK 407.0 0.398034398034398 0.601965601965602 0.445855518214844 0.737198693538605 0.5915271058767245 0.291343175323761 0 0 0 0 K00341 0.4171428571428571 0.5584045584045584 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 252.0 288.0 106.0 3.0 0.592592592592593 CP 201.0 285.0 4.0 0.880658436213992 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 486.0 0.4135802469135802 0.5864197530864198 0.698312229196137 0.912164574768584 0.8052384019823605 0.213852345572447 0 1 0 1 K00342 0.5142857142857142 0.5868945868945868 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 228.0 490.0 459.0 2.0 0.940499040307102 C 233.0 288.0 3.0 0.738963531669866 COG1008 NADH:ubiquinone_oxidoreductase_subunit_4_(chain_M) NuoM 521.0 0.4472168905950096 0.5527831094049904 0.0394881846556083 0.92379944869927 0.4816438166774391 0.8843112640436617 0 0 0 0 K00343 0.3714285714285714 0.5270655270655271 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 233.0 377.0 365.0 2.0 0.969151670951157 C 137.0 252.0 2.0 0.933161953727506 COG1007 NADH:ubiquinone_oxidoreductase_subunit_2_(chain_N) NuoN 389.0 0.352185089974293 0.6478149100257069 0.0451851059062948 0.048619252606477 0.0469021792563859 0.0034341467001822 0 0 0 0 K00344 0.1828571428571428 0.4672364672364672 qor, CRYZ; NADPH:quinone reductase [EC:1.6.5.5] 91.0 571.0 536.0 7.0 0.918006430868167 C 181.0 440.0 5.0 0.918006430868167 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 621.0 0.2914653784219002 0.7085346215780999 0.140953141312555 0.362449357611783 0.251701249462169 0.2214962162992279 0 0 0 0 K00346 0.0 0.1396011396011396 nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:7.2.1.1] 388.0 50.0 0.0 1.0 1.0 C 0.0 50.0 1.0 1.0 COG1726 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrA NqrA 50.0 0.0 1.0 0.0132232247327943 0.0136716866007573 0.0134474556667758 0.000448461867963 0 0 0 0 K00347 0.0085714285714285 0.2165242165242165 nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:7.2.1.1] 249.0 77.0 71.0 3.0 0.885057471264368 C 3.0 83.0 2.0 0.701149425287356 COG4658 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfD_subunit RnfD 86.0 0.0348837209302325 0.9651162790697676 0.791828476881995 0.797010519244428 0.7944194980632115 0.005182042362433 0 0 1 1 K00348 0.0 0.1737891737891738 nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:7.2.1.1] 128.0 61.0 59.0 2.0 0.968253968253968 C 0.0 63.0 3.0 0.936507936507936 COG2869 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrC NqrC 63.0 0.0 1.0 0.0114214765705112 0.0352450206246554 0.0233332485975833 0.0238235440541441 0 0 0 0 K00349 0.0 0.168091168091168 nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:7.2.1.1] 188.0 60.0 0.0 1.0 1.0 C 0.0 60.0 1.0 1.0 COG1347 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrD NqrD 60.0 0.0 1.0 0.0084414819184672 0.015351130246676 0.0118963060825716 0.0069096483282087 0 0 0 0 K00350 0.0 0.1709401709401709 nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:7.2.1.1] 195.0 59.0 57.0 2.0 0.967213114754098 C 0.0 61.0 2.0 0.983606557377049 COG2209 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrE NqrE 61.0 0.0 1.0 0.0280057344162129 0.0147276944011436 0.0213667144086782 0.0132780400150692 0 0 0 0 K00351 0.0085714285714285 0.1823361823361823 nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:7.2.1.1] 344.0 69.0 0.0 1.0 1.0 C 4.0 65.0 1.0 1.0 COG2871 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrF NqrF 69.0 0.0579710144927536 0.9420289855072465 0.0150783017000711 0.0251741586867151 0.0201262301933931 0.010095856986644 0 0 0 0 K00354 0.0 0.0626780626780626 E1.6.99.1; NADPH2 dehydrogenase [EC:1.6.99.1] 316.0 22.0 0.0 1.0 1.0 C 0.0 22.0 1.0 1.0 COG1902 2,4-dienoyl-CoA_reductase_or_related_NADH-dependent_reductase,_Old_Yellow_Enzyme_(OYE)_family FadH 22.0 0.0 1.0 0.0500236709280459 0.262090798656774 0.1560572347924099 0.212067127728728 0 0 0 0 K00355 0.06 0.1282051282051282 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] path:map00130,path:map01100,path:map01110,path:map01240,path:map05200,path:map05208,path:map05225,path:map05418 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Pathways in cancer,Chemical carcinogenesis - reactive oxygen species,Hepatocellular carcinoma,Fluid shear stress and atherosclerosis 86.0 58.0 48.0 5.0 0.773333333333333 S 22.0 53.0 3.0 0.906666666666667 COG2249 Putative_NADPH-quinone_reductase_(modulator_of_drug_activity_B) MdaB 75.0 0.2933333333333333 0.7066666666666667 0.0416156222166053 0.179725749366403 0.1106706857915041 0.1381101271497977 0 0 0 0 K00356 0.2171428571428571 0.2478632478632478 106.0 102.0 27.0 4.0 0.502463054187192 GM 79.0 124.0 3.0 0.83743842364532 COG0702 Uncharacterized_conserved_protein_YbjT,_contains_NAD(P)-binding_and_DUF2867_domains YbjT 203.0 0.3891625615763547 0.6108374384236454 0.0119240491136927 0.0027251527431458 0.0073246009284192 0.0091988963705469 0 0 0 0 K00357 0.0 0.0028490028490028 QDPR; dihydropteridine reductase [EC:1.5.1.34] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 228.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K00360 0.0 0.0427350427350427 nasB; assimilatory nitrate reductase electron transfer subunit [EC:1.7.99.-] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 449.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 15.0 0.0 1.0 0.0003623912921121 0.0425180617501638 0.0214402265211379 0.0421556704580517 0 0 0 0 K00362 0.0457142857142857 0.2962962962962963 nirB; nitrite reductase (NADH) large subunit [EC:1.7.1.15] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 205.0 133.0 127.0 5.0 0.910958904109589 C 18.0 125.0 5.0 0.849315068493151 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 143.0 0.1258741258741259 0.8741258741258742 0.771024844892741 0.922929452982282 0.8469771489375115 0.1519046080895409 1 1 1 1 K00363 0.0514285714285714 0.2678062678062678 nirD; nitrite reductase (NADH) small subunit [EC:1.7.1.15] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 51.0 136.0 132.0 2.0 0.971428571428571 P 24.0 116.0 2.0 0.985714285714286 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 140.0 0.1714285714285714 0.8285714285714286 0.0839636164877667 0.465008570180062 0.2744860933339143 0.3810449536922953 0 0 0 0 K00364 0.1485714285714285 0.1538461538461538 guaC, GMPR; GMP reductase [EC:1.7.1.7] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 283.0 106.0 97.0 2.0 0.921739130434783 F 56.0 59.0 1.0 1.0 COG0516 IMP_dehydrogenase/GMP_reductase GuaB 115.0 0.4869565217391304 0.5130434782608696 0.518578355859515 0.549686458645427 0.5341324072524709 0.031108102785912 0 1 0 1 K00365 0.0142857142857142 0.0655270655270655 uaZ; urate oxidase [EC:1.7.3.3] path:map00230,path:map00232,path:map01100,path:map01120 Purine metabolism,Caffeine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 255.0 19.0 14.0 3.0 0.678571428571429 Q 5.0 23.0 2.0 0.857142857142857 COG3648 Uricase_(urate_oxidase) UriC 28.0 0.1785714285714285 0.8214285714285714 0.0051033280748059 0.0162117123614924 0.0106575202181491 0.0111083842866865 0 0 0 0 K00366 0.1542857142857142 0.2535612535612536 nirA; ferredoxin-nitrite reductase [EC:1.7.7.1] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 280.0 111.0 25.0 6.0 0.523584905660377 C 98.0 114.0 7.0 0.915094339622642 COG0155 Sulfite_reductase,_beta_subunit_(hemoprotein) CysI 212.0 0.4622641509433962 0.5377358490566038 0.5347827863375 0.578995049387938 0.556888917862719 0.044212263050438 0 1 0 1 K00367 0.0914285714285714 0.1054131054131054 narB; ferredoxin-nitrate reductase [EC:1.7.7.2] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 549.0 86.0 0.0 1.0 1.0 C 44.0 42.0 2.0 0.976744186046512 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 86.0 0.5116279069767442 0.4883720930232558 0.695601202351393 0.044104820523361 0.369853011437377 0.651496381828032 0 1 0 1 K00368 0.1228571428571428 0.1737891737891738 nirK; nitrite reductase (NO-forming) [EC:1.7.2.1] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 43.0 104.0 66.0 8.0 0.622754491017964 Q 61.0 106.0 7.0 0.694610778443114 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 167.0 0.3652694610778443 0.6347305389221557 0.0029061276985047 0.0975776246463247 0.0502418761724147 0.09467149694782 0 0 0 0 K00370 0.0571428571428571 0.1282051282051282 narG, narZ, nxrA; nitrate reductase / nitrite oxidoreductase, alpha subunit [EC:1.7.5.1 1.7.99.-] path:map00910,path:map01100,path:map01120,path:map02020 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 581.0 90.0 0.0 1.0 1.0 C 28.0 62.0 5.0 0.6 COG5013 Nitrate_reductase_alpha_subunit NarG 90.0 0.3111111111111111 0.6888888888888889 0.461213591912601 0.811193603863539 0.63620359788807 0.349980011950938 0 0 0 0 K00371 0.0514285714285714 0.1339031339031339 narH, narY, nxrB; nitrate reductase / nitrite oxidoreductase, beta subunit [EC:1.7.5.1 1.7.99.-] path:map00910,path:map01100,path:map01120,path:map02020 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 275.0 76.0 0.0 1.0 1.0 C 20.0 56.0 1.0 1.0 COG1140 Nitrate_reductase_beta_subunit NarY 76.0 0.2631578947368421 0.7368421052631579 0.208439341032872 0.448266698176217 0.3283530196045445 0.239827357143345 0 0 0 0 K00372 0.1114285714285714 0.1994301994301994 nasA; assimilatory nitrate reductase catalytic subunit [EC:1.7.99.-] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 450.0 135.0 131.0 2.0 0.971223021582734 C 53.0 86.0 4.0 0.863309352517986 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 139.0 0.381294964028777 0.6187050359712231 0.124143620302625 0.404282236993389 0.264212928648007 0.280138616690764 0 0 0 0 K00373 0.04 0.1367521367521367 narJ, narW; nitrate reductase molybdenum cofactor assembly chaperone NarJ/NarW path:map02020 Two-component system 61.0 71.0 0.0 1.0 1.0 C 14.0 57.0 2.0 0.901408450704225 COG2180 Nitrate_reductase_assembly_protein_NarJ,_required_for_insertion_of_molybdenum_cofactor NarJ 71.0 0.1971830985915492 0.8028169014084507 0.23883397311484 0.403931303159961 0.3213826381374005 0.165097330045121 0 0 0 0 K00374 0.0542857142857142 0.1481481481481481 narI, narV; nitrate reductase gamma subunit [EC:1.7.5.1 1.7.99.-] path:map00910,path:map01100,path:map01120,path:map02020 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 141.0 83.0 0.0 1.0 1.0 C 25.0 58.0 1.0 1.0 COG2181 Nitrate_reductase_gamma_subunit NarI 83.0 0.3012048192771084 0.6987951807228916 0.514153363549452 0.626428219138881 0.5702907913441665 0.112274855589429 0 1 0 1 K00375 0.0 0.301994301994302 K00375; GntR family transcriptional regulator / MocR family aminotransferase 242.0 142.0 105.0 3.0 0.784530386740332 K 0.0 181.0 1.0 1.0 COG1167 DNA-binding_transcriptional_regulator,_MocR_family,_contains_an_aminotransferase_domain ARO8 181.0 0.0 1.0 0.006684502599422 0.112002292984544 0.059343397791983 0.105317790385122 0 0 0 0 K00376 0.0657142857142857 0.0997150997150997 nosZ; nitrous-oxide reductase [EC:1.7.2.4] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 514.0 62.0 0.0 1.0 1.0 C 24.0 38.0 2.0 0.903225806451613 COG4263 Nitrous_oxide_reductase NosZ 62.0 0.3870967741935484 0.6129032258064516 0.450765375329961 0.631148902074394 0.5409571387021775 0.1803835267444329 0 0 0 0 K00380 0.0542857142857142 0.1823361823361823 cysJ; sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 96.0 62.0 33.0 5.0 0.563636363636364 P 25.0 85.0 5.0 0.8 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 110.0 0.2272727272727272 0.7727272727272727 0.0107213624018288 0.0243451286082822 0.0175332455050555 0.0136237662064534 0 0 0 0 K00381 0.0171428571428571 0.2564102564102564 cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 326.0 80.0 66.0 4.0 0.784313725490196 C 6.0 96.0 1.0 1.0 COG0155 Sulfite_reductase,_beta_subunit_(hemoprotein) CysI 102.0 0.0588235294117647 0.9411764705882352 0.385525823684291 0.217599858491936 0.3015628410881135 0.167925965192355 0 0 0 0 K00382 0.5457142857142857 0.7948717948717948 DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] path:map00010,path:map00020,path:map00260,path:map00280,path:map00310,path:map00380,path:map00620,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200,path:map01240 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Glycine, serine and threonine metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,Tryptophan metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of cofactors 129.0 893.0 892.0 2.0 0.998881431767338 C 348.0 546.0 3.0 0.98993288590604 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 894.0 0.3892617449664429 0.610738255033557 0.0979894201604634 0.0328624184382231 0.0654259192993432 0.0651270017222403 0 0 0 0 K00383 0.0457142857142857 0.2222222222222222 GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7] path:map00480,path:map01100,path:map04918,path:map05415 Glutathione metabolism,Metabolic pathways,Thyroid hormone synthesis,Diabetic cardiomyopathy 315.0 114.0 0.0 1.0 1.0 C 21.0 93.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 114.0 0.1842105263157894 0.8157894736842105 0.0163669536196272 0.0032329546462064 0.0097999541329168 0.0131339989734208 0 0 0 0 K00384 0.86 0.9116809116809116 trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9] path:map00450 Selenocompound metabolism 56.0 531.0 17.0 6.0 0.478378378378378 C 500.0 604.0 13.0 0.938738738738739 COG0492 Thioredoxin_reductase TrxB 1104.0 0.4528985507246377 0.5471014492753623 0.130583953726377 0.283690171262024 0.2071370624942005 0.153106217535647 0 0 0 0 K00385 0.0 0.0256410256410256 asrC; anaerobic sulfite reductase subunit C path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 314.0 10.0 0.0 1.0 1.0 C 0.0 10.0 1.0 1.0 COG2221 Dissimilatory_sulfite_reductase_(desulfoviridin),_alpha_and_beta_subunits DsrA 10.0 0.0 1.0 0.0613357739590409 0.685758550390843 0.3735471621749419 0.6244227764318021 0 0 0 0 K00387 0.0 0.037037037037037 SUOX; sulfite oxidase [EC:1.8.3.1] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 292.0 12.0 10.0 4.0 0.75 S 0.0 16.0 1.0 1.0 COG2041 Molybdopterin-dependent_catalytic_subunit_of_periplasmic_DMSO/TMAO_and_protein-methionine-sulfoxide_reductases MsrP 16.0 0.0 1.0 0.0150066047096667 0.0615457158460238 0.0382761602778452 0.0465391111363571 0 0 0 0 K00389 0.0542857142857142 0.1566951566951566 yidH; putative membrane protein 67.0 83.0 0.0 1.0 1.0 S 20.0 63.0 2.0 0.987951807228916 COG2149 Uncharacterized_membrane_protein_YidH,_DUF202_family YidH 83.0 0.2409638554216867 0.7590361445783133 0.0274845402219841 0.0222990512089733 0.0248917957154787 0.0051854890130107 0 0 0 0 K00390 0.5457142857142857 0.50997150997151 cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 41.0 207.0 24.0 8.0 0.416498993963783 EH 291.0 210.0 14.0 0.849206349206349 COG0175 3'-phosphoadenosine_5'-phosphosulfate_sulfotransferase_(PAPS_reductase)/FAD_synthetase_or_related_enzyme CysD 501.0 0.5808383233532934 0.4191616766467065 0.56283162406027 0.851029490243142 0.7069305571517059 0.288197866182872 0 1 0 1 K00392 0.0485714285714285 0.3219373219373219 sir; sulfite reductase (ferredoxin) [EC:1.8.7.1] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 256.0 121.0 105.0 5.0 0.846153846153846 C 19.0 124.0 2.0 0.986013986013986 COG0155 Sulfite_reductase,_beta_subunit_(hemoprotein) CysI 143.0 0.1328671328671328 0.8671328671328671 0.815044183464543 0.885851609510368 0.8504478964874556 0.070807426045825 1 1 1 1 K00394 0.0542857142857142 0.1082621082621082 aprA; adenylylsulfate reductase, subunit A [EC:1.8.99.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 497.0 64.0 0.0 1.0 1.0 C 23.0 41.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 64.0 0.359375 0.640625 0.0049933623307937 0.213229393915821 0.1091113781233073 0.2082360315850273 0 0 0 0 K00395 0.0571428571428571 0.1054131054131054 aprB; adenylylsulfate reductase, subunit B [EC:1.8.99.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 86.0 60.0 0.0 1.0 1.0 C 20.0 40.0 3.0 0.916666666666667 COG1146 NAD-dependent_dihydropyrimidine_dehydrogenase,_PreA_subunit PreA 60.0 0.3333333333333333 0.6666666666666666 0.0156733823202034 0.17043234763794 0.0930528649790717 0.1547589653177365 0 0 0 0 K00399 0.1771428571428571 0.0 mcrA; methyl-coenzyme M reductase alpha subunit [EC:2.8.4.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 517.0 85.0 0.0 1.0 1.0 H 85.0 0.0 1.0 1.0 COG4058 Methyl_coenzyme_M_reductase,_alpha_subunit McorA 85.0 1.0 0.0 0.0012313009133318 0.0205071703711798 0.0108692356422558 0.019275869457848 0 0 0 0 K00400 0.2057142857142857 0.0 K00400; methyl coenzyme M reductase system, component A2 path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 403.0 138.0 0.0 1.0 1.0 E 138.0 0.0 1.0 1.0 COG1123 ABC-type_glutathione_transport_system_ATPase_component,_contains_duplicated_ATPase_domain GsiA 138.0 1.0 0.0 0.0011464023907334 0.0998948927482008 0.0505206475694671 0.0987484903574674 0 0 0 0 K00401 0.1771428571428571 0.0 mcrB; methyl-coenzyme M reductase beta subunit [EC:2.8.4.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 425.0 85.0 0.0 1.0 1.0 H 85.0 0.0 1.0 1.0 COG4054 Methyl_coenzyme_M_reductase,_beta_subunit McorB 85.0 1.0 0.0 0.0340077592393947 0.728332788052144 0.3811702736457693 0.6943250288127493 0 0 0 0 K00402 0.1771428571428571 0.0 mcrG; methyl-coenzyme M reductase gamma subunit [EC:2.8.4.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 243.0 83.0 0.0 1.0 1.0 H 83.0 0.0 1.0 1.0 COG4057 Methyl_coenzyme_M_reductase,_gamma_subunit McorG 83.0 1.0 0.0 0.0041019114782718 0.129896497145826 0.0669992043120489 0.1257945856675542 0 0 0 0 K00404 0.0057142857142857 0.1965811965811965 ccoN; cytochrome c oxidase cbb3-type subunit I [EC:7.1.1.9] path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 418.0 74.0 70.0 3.0 0.902439024390244 C 2.0 80.0 3.0 0.902439024390244 COG3278 Cbb3-type_cytochrome_oxidase,_subunit_1 CcoN 82.0 0.024390243902439 0.975609756097561 0.0106740323702238 0.061135194880173 0.0359046136251984 0.0504611625099492 0 0 0 0 K00405 0.0057142857142857 0.2336182336182336 ccoO; cytochrome c oxidase cbb3-type subunit II path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 88.0 103.0 0.0 1.0 1.0 C 2.0 101.0 2.0 0.563106796116505 COG2993 Cbb3-type_cytochrome_oxidase,_cytochrome_c_subunit_FixO CcoO 103.0 0.0194174757281553 0.9805825242718448 0.0150011623868173 0.0499931951700216 0.0324971787784194 0.0349920327832043 0 0 0 0 K00406 0.0 0.2792022792022792 ccoP; cytochrome c oxidase cbb3-type subunit III path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 25.0 114.0 108.0 3.0 0.942148760330578 C 0.0 121.0 3.0 0.892561983471074 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 121.0 0.0 1.0 0.0047016625017822 0.0154112195703771 0.0100564410360796 0.0107095570685949 0 0 0 0 K00407 0.0 0.1082621082621082 ccoQ; cytochrome c oxidase cbb3-type subunit IV path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 36.0 34.0 32.0 3.0 0.894736842105263 O 0.0 38.0 3.0 0.947368421052632 COG4736 Cbb3-type_cytochrome_oxidase,_subunit_3 CcoQ 38.0 0.0 1.0 0.0139646157889375 0.0272674091530401 0.0206160124709888 0.0133027933641026 0 0 0 0 K00410 0.0028571428571428 0.0712250712250712 fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 337.0 27.0 0.0 1.0 1.0 C 1.0 26.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 27.0 0.037037037037037 0.9629629629629628 0.0093944483282007 0.0190070060026735 0.0142007271654371 0.0096125576744728 0 0 0 0 K00411 0.0514285714285714 0.2022792022792023 UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8] path:map00190,path:map01100,path:map02020,path:map04260,path:map04714,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Two-component system,Cardiac muscle contraction,Thermogenesis,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 103.0 104.0 0.0 1.0 1.0 C 25.0 79.0 1.0 1.0 COG0723 Rieske_Fe-S_protein QcrA/PetC 104.0 0.2403846153846154 0.7596153846153846 0.0460543825199556 0.192871201474496 0.1194627919972257 0.1468168189545404 0 0 0 0 K00412 0.0885714285714285 0.282051282051282 CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit path:map00190,path:map01100,path:map02020,path:map04260,path:map04714,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Two-component system,Cardiac muscle contraction,Thermogenesis,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 237.0 142.0 140.0 2.0 0.986111111111111 C 31.0 113.0 2.0 0.986111111111111 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 144.0 0.2152777777777778 0.7847222222222222 0.0137259110147875 0.632670409066311 0.3231981600405492 0.6189444980515235 0 0 0 0 K00413 0.0 0.1794871794871795 CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit path:map00190,path:map01100,path:map02020,path:map04260,path:map04714,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Two-component system,Cardiac muscle contraction,Thermogenesis,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 127.0 56.0 44.0 2.0 0.823529411764706 C 0.0 68.0 3.0 0.852941176470588 COG2857 Cytochrome_c1 CYT1 68.0 0.0 1.0 0.0037404719985047 0.0083551579800158 0.0060478149892602 0.0046146859815111 0 0 0 0 K00422 0.0 0.0028490028490028 E1.10.3.1; polyphenol oxidase [EC:1.10.3.1] path:map00350,path:map00950,path:map01100,path:map01110 Tyrosine metabolism,Isoquinoline alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 545.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DBCY 1.0 0.0 1.0 0 0 0 0 K00423 0.0 0.0056980056980056 E1.10.3.3; L-ascorbate oxidase [EC:1.10.3.3] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 55.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 3.0 0.0 1.0 0 0 0 0 K00424 0.0 0.0598290598290598 cydX; cytochrome bd-I ubiquinol oxidase subunit X [EC:7.1.1.7] path:map00190,path:map02020 Oxidative phosphorylation,Two-component system 26.0 22.0 0.0 1.0 1.0 S 0.0 22.0 2.0 0.909090909090909 COG4890 Predicted_outer_membrane_lipoprotein 22.0 0.0 1.0 0.0093566220463585 0.0208443792610139 0.0151005006536862 0.0114877572146554 0 0 0 0 K00425 0.18 0.4928774928774929 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7] path:map00190,path:map02020 Oxidative phosphorylation,Two-component system 242.0 336.0 0.0 1.0 1.0 C 106.0 230.0 1.0 1.0 COG1271 Cytochrome_bd-type_quinol_oxidase,_subunit_1 AppC 336.0 0.3154761904761904 0.6845238095238095 0.0145994397968793 0.0777652408390537 0.0461823403179665 0.0631658010421744 0 0 0 0 K00426 0.1 0.4729344729344729 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7] path:map00190,path:map02020 Oxidative phosphorylation,Two-component system 217.0 230.0 0.0 1.0 1.0 C 41.0 195.0 2.0 0.974576271186441 COG1294 Cytochrome_bd-type_quinol_oxidase,_subunit_2 AppB 236.0 0.173728813559322 0.826271186440678 0.0178198824755579 0.0324927989405324 0.0251563407080451 0.0146729164649744 0 0 0 0 K00427 0.0057142857142857 0.0199430199430199 lldP, lctP; L-lactate permease 441.0 13.0 12.0 2.0 0.928571428571429 C 3.0 11.0 1.0 1.0 COG1620 L-lactate_permease LldP 14.0 0.2142857142857142 0.7857142857142857 0.0449157046780782 0.0787470542978516 0.0618313794879648 0.0338313496197734 0 0 0 0 K00428 0.0171428571428571 0.2877492877492877 E1.11.1.5; cytochrome c peroxidase [EC:1.11.1.5] 94.0 148.0 100.0 4.0 0.714975845410628 C 6.0 201.0 5.0 0.942028985507247 COG1858 Cytochrome_c_peroxidase MauG 207.0 0.0289855072463768 0.9710144927536232 0.0050122716151711 0.0223071936533848 0.0136597326342779 0.0172949220382137 0 0 0 0 K00432 0.0285714285714285 0.3817663817663818 gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9] path:map00480,path:map00590,path:map01100,path:map04918,path:map05014,path:map05016,path:map05022 Glutathione metabolism,Arachidonic acid metabolism,Metabolic pathways,Thyroid hormone synthesis,Amyotrophic lateral sclerosis,Huntington disease,Pathways of neurodegeneration - multiple diseases 121.0 178.0 172.0 3.0 0.956989247311828 O 10.0 176.0 2.0 0.989247311827957 COG0386 Thioredoxin/glutathione_peroxidase_BtuE,_reduces_lipid_peroxides BtuE 186.0 0.053763440860215 0.946236559139785 0.0063225748134555 0.227321370364818 0.1168219725891367 0.2209987955513625 0 0 0 0 K00433 0.06 0.2022792022792023 cpo; non-heme chloroperoxidase [EC:1.11.1.10] 93.0 103.0 77.0 3.0 0.78030303030303 I 23.0 109.0 3.0 0.78030303030303 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 132.0 0.1742424242424242 0.8257575757575758 0.0738157588379435 0.308255445564661 0.1910356022013022 0.2344396867267175 0 0 0 0 K00435 0.0 0.0512820512820512 hemQ; hydrogen peroxide-dependent heme synthase [EC:1.3.98.5] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 198.0 15.0 12.0 2.0 0.833333333333333 S 0.0 18.0 1.0 1.0 COG3253 Coproheme_decarboxylase/chlorite_dismutase HemQ 18.0 0.0 1.0 0.0528178897485809 0.103120901130056 0.0779693954393184 0.050303011381475 0 0 0 0 K00436 0.0857142857142857 0.1339031339031339 hoxH; NAD-reducing hydrogenase large subunit [EC:1.12.1.2] 189.0 72.0 58.0 2.0 0.837209302325581 C 32.0 54.0 3.0 0.616279069767442 COG3259 Coenzyme_F420-reducing_hydrogenase,_alpha_subunit FrhA 86.0 0.3720930232558139 0.627906976744186 0.649423866568602 0.937071273823068 0.793247570195835 0.287647407254466 0 1 0 1 K00437 0.0 0.0227920227920227 hydB; [NiFe] hydrogenase large subunit [EC:1.12.2.1] 326.0 9.0 0.0 1.0 1.0 C 0.0 9.0 1.0 1.0 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 9.0 0.0 1.0 9.83005879921587e-10 5.44948704384403e-06 2.725235024861976e-06 5.448504037964109e-06 0 0 0 0 K00440 0.0914285714285714 0.0028490028490028 frhA; coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 348.0 42.0 0.0 1.0 1.0 C 41.0 1.0 3.0 0.928571428571429 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 42.0 0.9761904761904762 0.0238095238095238 0.813885016433358 0.661846338161774 0.737865677297566 0.152038678271584 0 0 1 1 K00441 0.34 0.0911680911680911 frhB; coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 93.0 257.0 253.0 3.0 0.980916030534351 C 224.0 37.0 7.0 0.923664122137405 COG1035 Coenzyme_F420-reducing_hydrogenase,_beta_subunit FrhB 261.0 0.8582375478927203 0.1417624521072797 0.850905311916863 0.981877647255948 0.9163914795864054 0.1309723353390849 1 1 1 1 K00442 0.0885714285714285 0.037037037037037 frhD; coenzyme F420 hydrogenase subunit delta path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 114.0 53.0 0.0 1.0 1.0 C 40.0 13.0 1.0 1.0 COG0680 Ni,Fe-hydrogenase_maturation_factor HyaD 53.0 0.7547169811320755 0.2452830188679245 0.144354147332838 0.114043331402747 0.1291987393677925 0.0303108159300909 0 0 0 0 K00443 0.0828571428571428 0.0028490028490028 frhG; coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 216.0 37.0 0.0 1.0 1.0 C 36.0 1.0 2.0 0.972972972972973 COG1941 Coenzyme_F420-reducing_hydrogenase,_gamma_subunit FrhG 37.0 0.972972972972973 0.027027027027027 0.739443862424573 0.85479504298512 0.7971194527048465 0.1153511805605469 0 0 0 1 K00446 0.02 0.0826210826210826 dmpB, xylE; catechol 2,3-dioxygenase [EC:1.13.11.2] path:map00361,path:map00362,path:map00622,path:map00643,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Xylene degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 195.0 50.0 49.0 4.0 0.943396226415094 E 9.0 44.0 2.0 0.981132075471698 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 53.0 0.1698113207547169 0.8301886792452831 0.0063629590291367 0.863895963934026 0.4351294614815814 0.8575330049048893 0 0 0 0 K00448 0.0 0.0883190883190883 pcaG; protocatechuate 3,4-dioxygenase, alpha subunit [EC:1.13.11.3] path:map00362,path:map00624,path:map01100,path:map01120,path:map01220 Benzoate degradation,Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 154.0 28.0 25.0 2.0 0.903225806451613 Q 0.0 33.0 2.0 0.939393939393939 COG3485 Protocatechuate_3,4-dioxygenase_beta_subunit PcaH 33.0 0.0 1.0 0.0007573412440947 0.0108199617330716 0.0057886514885831 0.0100626204889769 0 0 0 0 K00449 0.0 0.1282051282051282 pcaH; protocatechuate 3,4-dioxygenase, beta subunit [EC:1.13.11.3] path:map00362,path:map00624,path:map01100,path:map01120,path:map01220 Benzoate degradation,Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 160.0 43.0 37.0 2.0 0.877551020408163 Q 0.0 49.0 2.0 0.979591836734694 COG3485 Protocatechuate_3,4-dioxygenase_beta_subunit PcaH 49.0 0.0 1.0 0.006254914724169 0.0160868473038882 0.0111708810140286 0.0098319325797192 0 0 0 0 K00450 0.06 0.0512820512820512 E1.13.11.4; gentisate 1,2-dioxygenase [EC:1.13.11.4] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 90.0 28.0 20.0 4.0 0.682926829268293 Q 22.0 19.0 3.0 0.585365853658537 COG3435 Gentisate_1,2-dioxygenase 41.0 0.5365853658536586 0.4634146341463415 0.0086084554250358 0.0333536484591809 0.0209810519421083 0.0247451930341451 0 0 0 0 K00451 0.0457142857142857 0.2393162393162393 HGD, hmgA; homogentisate 1,2-dioxygenase [EC:1.13.11.5] path:map00350,path:map00643,path:map01100,path:map01120 Tyrosine metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 271.0 85.0 65.0 2.0 0.80952380952381 Q 17.0 88.0 2.0 0.99047619047619 COG3508 Homogentisate_1,2-dioxygenase HmgA 105.0 0.1619047619047619 0.8380952380952381 0.0047267069059319 0.0405380312803077 0.0226323690931198 0.0358113243743758 0 0 0 0 K00452 0.0085714285714285 0.0598290598290598 HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6] path:map00380,path:map01100,path:map01240 Tryptophan metabolism,Metabolic pathways,Biosynthesis of cofactors 161.0 15.0 9.0 5.0 0.6 G 3.0 22.0 2.0 0.68 COG0662 Mannose-6-phosphate_isomerase,_cupin_superfamily ManC 25.0 0.12 0.88 0.115227690117637 0.560449109216278 0.3378383996669575 0.445221419098641 0 0 0 0 K00453 0.0457142857142857 0.1652421652421652 TDO2, kynA; tryptophan 2,3-dioxygenase [EC:1.13.11.11] path:map00380,path:map01100,path:map01240 Tryptophan metabolism,Metabolic pathways,Biosynthesis of cofactors 180.0 79.0 0.0 1.0 1.0 E 16.0 63.0 1.0 1.0 COG3483 Tryptophan_2,3-dioxygenase_(vermilion) TDO2 79.0 0.2025316455696202 0.7974683544303798 0.057244756547651 0.894457180148285 0.475850968347968 0.837212423600634 0 0 0 0 K00455 0.0142857142857142 0.0227920227920227 hpaD, hpcB; 3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15] path:map00350,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 252.0 14.0 0.0 1.0 1.0 S 6.0 8.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 14.0 0.4285714285714285 0.5714285714285714 0.0225683222095318 0.0481486071748645 0.0353584646921981 0.0255802849653327 0 0 0 0 K00456 0.0114285714285714 0.017094017094017 CDO1; cysteine dioxygenase [EC:1.13.11.20] path:map00270,path:map00430,path:map01100 Cysteine and methionine metabolism,Taurine and hypotaurine metabolism,Metabolic pathways 130.0 5.0 2.0 3.0 0.555555555555556 C 4.0 8.0 2.0 0.916666666666667 COG5553 Predicted_metal-dependent_enzyme_of_the_double-stranded_beta_helix_superfamily 12.0 0.3333333333333333 0.6666666666666666 0.0499733486326874 0.0996229743809333 0.0747981615068103 0.0496496257482459 0 0 0 0 K00457 0.0457142857142857 0.2678062678062678 HPD, hppD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27] path:map00130,path:map00350,path:map00360,path:map01100,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,Phenylalanine metabolism,Metabolic pathways,Biosynthesis of cofactors 248.0 86.0 57.0 4.0 0.637037037037037 E 18.0 116.0 3.0 0.740740740740741 COG3185 4-hydroxyphenylpyruvate_dioxygenase_and_related_hemolysins HppD 134.0 0.1343283582089552 0.8656716417910447 0.0056224228548161 0.882844904276518 0.444233663565667 0.8772224814217019 0 0 0 0 K00459 0.0657142857142857 0.3817663817663818 ncd2, npd; nitronate monooxygenase [EC:1.13.12.16] path:map00910,path:map01100 Nitrogen metabolism,Metabolic pathways 123.0 213.0 202.0 5.0 0.906382978723404 S 28.0 207.0 1.0 1.0 COG2070 NAD(P)H-dependent_flavin_oxidoreductase_YrpB,_nitropropane_dioxygenase_family YrpB 235.0 0.1191489361702127 0.8808510638297873 0.105042322227564 0.131795570144288 0.118418946185926 0.0267532479167239 0 0 0 0 K00461 0.0 0.0056980056980056 ALOX5; arachidonate 5-lipoxygenase [EC:1.13.11.34] path:map00590,path:map01100,path:map04664,path:map04726,path:map04913,path:map05145 Arachidonic acid metabolism,Metabolic pathways,Fc epsilon RI signaling pathway,Serotonergic synapse,Ovarian steroidogenesis,Toxoplasmosis 63.0 1.0 0.0 2.0 0.5 S 0.0 2.0 2.0 0.5 2DBJG 2.0 0.0 1.0 0 0 0 0 K00462 0.0 0.0085470085470085 bphC; biphenyl-2,3-diol 1,2-dioxygenase [EC:1.13.11.39] path:map00361,path:map00621,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 313.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 5.0 0.0 1.0 4.25317329485197e-12 0.0712518684507378 0.0356259342274954 0.0712518684464846 0 0 0 0 K00463 0.0085714285714285 0.0227920227920227 IDO, INDO; indoleamine 2,3-dioxygenase [EC:1.13.11.52] path:map00380,path:map01100,path:map01240,path:map05143 Tryptophan metabolism,Metabolic pathways,Biosynthesis of cofactors,African trypanosomiasis 357.0 4.0 1.0 4.0 0.363636363636364 CI 3.0 8.0 3.0 0.636363636363636 COG5274 Cytochrome_b_involved_in_lipid_metabolism CYB5 11.0 0.2727272727272727 0.7272727272727273 0.0660052220757628 0.211366819646382 0.1386860208610724 0.1453615975706191 0 0 0 0 K00464 0.0057142857142857 0.0455840455840455 diox1; all-trans-8'-apo-beta-carotenal 15,15'-oxygenase [EC:1.13.11.75] 436.0 15.0 10.0 2.0 0.75 Q 2.0 18.0 1.0 1.0 COG3670 Carotenoid_cleavage_dioxygenase_or_a_related_enzyme 20.0 0.1 0.9 8.13474504069597e-13 0.0098652800565105 0.0049326400286619 0.009865280055697 0 0 0 0 K00466 0.0 0.0199430199430199 iaaM; tryptophan 2-monooxygenase [EC:1.13.12.3] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 427.0 7.0 6.0 3.0 0.777777777777778 E 0.0 9.0 3.0 0.666666666666667 COG1231 Monoamine_oxidase YobN 9.0 0.0 1.0 0.0270901540901989 0.118652025093926 0.0728710895920624 0.0915618710037271 0 0 0 0 K00467 0.0828571428571428 0.0398860398860398 E1.13.12.4; lactate 2-monooxygenase [EC:1.13.12.4] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 303.0 21.0 6.0 3.0 0.466666666666667 H 31.0 14.0 2.0 0.8 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 45.0 0.6888888888888889 0.3111111111111111 0.102820274686968 0.131494556042793 0.1171574153648805 0.028674281355825 0 0 0 0 K00469 0.0 0.037037037037037 MIOX; inositol oxygenase [EC:1.13.99.1] path:map00053,path:map00562,path:map01100,path:map01250 Ascorbate and aldarate metabolism,Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 278.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 KOG1573 14.0 0.0 1.0 0.0063144181641784 0.0096360490631582 0.0079752336136683 0.0033216308989798 0 0 0 0 K00471 0.0 0.0227920227920227 BBOX1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 17.0 8.0 6.0 2.0 0.8 Q 0.0 10.0 2.0 0.9 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 10.0 0.0 1.0 0.0077290066897304 0.0222521870854949 0.0149905968876126 0.0145231803957645 0 0 0 0 K00472 0.0 0.0284900284900284 P4HA; prolyl 4-hydroxylase [EC:1.14.11.2] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 192.0 12.0 0.0 1.0 1.0 O 0.0 12.0 1.0 1.0 COG3751 Proline_4-hydroxylase_(includes_Rps23_Pro-64_3,4-dihydroxylase_Tpa1),_contains_SM-20_domain EGL9 12.0 0.0 1.0 0.0448270148188398 0.0894998850994688 0.0671634499591543 0.0446728702806289 0 0 0 0 K00473 0.0028571428571428 0.0 PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 249.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1971 1.0 1.0 0.0 0 0 0 0 K00476 0.0 0.0056980056980056 ASPH; aspartate beta-hydroxylase [EC:1.14.11.16] path:map04020,path:map04260 Calcium signaling pathway,Cardiac muscle contraction 264.0 2.0 0.0 1.0 1.0 O 0.0 2.0 1.0 1.0 COG3555 Aspartyl/asparaginyl_beta-hydroxylase,_cupin_superfamily LpxO2 2.0 0.0 1.0 0 0 0 0 K00477 0.0 0.0427350427350427 PHYH; phytanoyl-CoA hydroxylase [EC:1.14.11.18] path:map04146 Peroxisome 67.0 78.0 74.0 3.0 0.939759036144578 Q 0.0 83.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 83.0 0.0 1.0 3.99828121430535e-14 2.64801018047316e-07 1.324005290150641e-07 2.648009780645038e-07 0 0 0 0 K00479 0.0 0.1025641025641025 gbcA, bmoA; glycine betaine monooxygenase A [EC:1.14.13.251] path:map00260 Glycine, serine and threonine metabolism 204.0 46.0 43.0 2.0 0.938775510204082 P 0.0 49.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 49.0 0.0 1.0 0.0146239606839195 0.0889535552839311 0.0517887579839253 0.0743295946000116 0 0 0 0 K00480 0.0 0.0854700854700854 E1.14.13.1; salicylate hydroxylase [EC:1.14.13.1] path:map00621,path:map00624,path:map00626,path:map01100,path:map01120,path:map01220 Dioxin degradation,Polycyclic aromatic hydrocarbon degradation,Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 234.0 43.0 39.0 2.0 0.914893617021277 CH 0.0 47.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 47.0 0.0 1.0 0.0085670709516917 0.0149554680522859 0.0117612695019888 0.0063883971005942 0 0 0 0 K00481 0.0 0.1054131054131054 pobA; p-hydroxybenzoate 3-monooxygenase [EC:1.14.13.2] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 359.0 39.0 35.0 2.0 0.906976744186046 CH 0.0 43.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 43.0 0.0 1.0 0.0114449402999679 0.0456103821104103 0.028527661205189 0.0341654418104424 0 0 0 0 K00483 0.0714285714285714 0.0997150997150997 hpaB; 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9] path:map00350,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 337.0 95.0 90.0 2.0 0.95 Q 39.0 61.0 1.0 1.0 COG2368 Aromatic_ring_hydroxylase YoaI 100.0 0.39 0.61 0.0336899158799599 0.221308708034407 0.1274993119571834 0.1876187921544471 0 0 0 0 K00484 0.0028571428571428 0.037037037037037 hpaC; flavin reductase (NADH) [EC:1.5.1.36] path:map00350,path:map00740,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Riboflavin metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 120.0 13.0 12.0 2.0 0.928571428571429 S 1.0 13.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 14.0 0.0714285714285714 0.9285714285714286 0.0292398939389464 0.0594509890454142 0.0443454414921803 0.0302110951064678 0 0 0 0 K00485 0.0 0.0085470085470085 FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-] path:map00430,path:map00982,path:map01100 Taurine and hypotaurine metabolism,Drug metabolism - cytochrome P450,Metabolic pathways 328.0 1.0 0.0 3.0 0.333333333333333 C 0.0 3.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 3.0 0.0 1.0 0 0 0 0 K00486 0.0085714285714285 0.074074074074074 KMO; kynurenine 3-monooxygenase [EC:1.14.13.9] path:map00380,path:map01100,path:map01240 Tryptophan metabolism,Metabolic pathways,Biosynthesis of cofactors 320.0 16.0 4.0 4.0 0.5 CH 4.0 28.0 2.0 0.90625 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 32.0 0.125 0.875 0.121134446128565 0.262803213762918 0.1919688299457415 0.141668767634353 0 0 0 0 K00491 0.0085714285714285 0.0598290598290598 nos; nitric-oxide synthase, bacterial [EC:1.14.14.47] path:map00220,path:map00330,path:map01100,path:map01110 Arginine biosynthesis,Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 193.0 11.0 2.0 4.0 0.354838709677419 C 3.0 27.0 4.0 0.483870967741936 COG4362 Nitric_oxide_synthase,_oxygenase_domain 30.0 0.1 0.9 0.0199072396315294 0.050889469565521 0.0353983545985251 0.0309822299339916 0 0 0 0 K00493 0.0142857142857142 0.0683760683760683 XANG; xanthocillin biosynthesis cytochrome P450 monooxygenase [EC:1.14.-.-] 282.0 27.0 20.0 3.0 0.75 Q 7.0 29.0 3.0 0.916666666666667 COG2124 Cytochrome_P450 CypX 36.0 0.1944444444444444 0.8055555555555556 0.0018462898487795 0.0130523252988814 0.0074493075738304 0.0112060354501019 0 0 0 0 K00494 0.0 0.0056980056980056 luxA; alkanal monooxygenase alpha chain [EC:1.14.14.3] path:map02020,path:map02024 Two-component system,Quorum sensing 314.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 2.0 0.0 1.0 0 0 0 0 K00496 0.0314285714285714 0.0797720797720797 alkB1_2, alkM; alkane 1-monooxygenase [EC:1.14.15.3] path:map00071,path:map00930 Fatty acid degradation,Caprolactam degradation 266.0 41.0 34.0 3.0 0.836734693877551 I 12.0 37.0 2.0 0.938775510204082 COG3239 Fatty_acid_desaturase DesA 49.0 0.2448979591836734 0.7551020408163265 0.0017429898067525 0.0094402348570957 0.0055916123319241 0.0076972450503432 0 0 0 0 K00499 0.0371428571428571 0.0854700854700854 CMO; choline monooxygenase [EC:1.14.15.7] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 196.0 45.0 0.0 1.0 1.0 P 13.0 32.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 45.0 0.2888888888888888 0.7111111111111111 0.129834835646041 0.580222524795932 0.3550286802209865 0.4503876891498909 0 0 0 0 K00500 0.0085714285714285 0.131054131054131 phhA, PAH; phenylalanine-4-hydroxylase [EC:1.14.16.1] path:map00360,path:map00400,path:map00790,path:map01100,path:map01230 Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Folate biosynthesis,Metabolic pathways,Biosynthesis of amino acids 178.0 49.0 46.0 2.0 0.942307692307692 E 4.0 47.0 1.0 1.0 COG3186 Phenylalanine-4-hydroxylase PhhA 51.0 0.0784313725490196 0.9215686274509804 0.0109569453438723 0.096715341099716 0.0538361432217941 0.0857583957558437 0 0 0 0 K00504 0.0 0.0085470085470085 PHM; peptidylglycine monooxygenase [EC:1.14.17.3] 154.0 2.0 1.0 2.0 0.666666666666667 CO 0.0 3.0 2.0 0.666666666666667 COG3391 DNA-binding_beta-propeller_fold_protein_YncE YncE 3.0 0.0 1.0 0 0 0 0 K00505 0.0114285714285714 0.0398860398860398 TYR; tyrosinase [EC:1.14.18.1] path:map00350,path:map00950,path:map00965,path:map01100,path:map01110,path:map04916 Tyrosine metabolism,Isoquinoline alkaloid biosynthesis,Betalain biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Melanogenesis 28.0 17.0 13.0 3.0 0.772727272727273 S 5.0 15.0 6.0 0.25 COG4447 Uncharacterized_conserved_protein_related_to_plant_photosystem_II_stability/assembly_factor 20.0 0.25 0.75 0.0207933520279993 0.194803550964957 0.1077984514964781 0.1740101989369576 0 0 0 0 K00507 0.0142857142857142 0.2535612535612536 SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] path:map01040,path:map01100,path:map01212,path:map03320,path:map04152,path:map04212,path:map04936 Biosynthesis of unsaturated fatty acids,Metabolic pathways,Fatty acid metabolism,PPAR signaling pathway,AMPK signaling pathway,Longevity regulating pathway - worm,Alcoholic liver disease 132.0 132.0 131.0 2.0 0.992481203007519 I 5.0 141.0 2.0 0.910958904109589 COG1398 Fatty-acid_desaturase OLE1 146.0 0.0342465753424657 0.9657534246575342 0.0011748099872952 0.0612437349378997 0.0312092724625974 0.0600689249506045 0 0 0 0 K00508 0.0 0.1225071225071225 E1.14.19.3; linoleoyl-CoA desaturase [EC:1.14.19.3] path:map00591,path:map01100 Linoleic acid metabolism,Metabolic pathways 268.0 61.0 59.0 2.0 0.968253968253968 I 0.0 63.0 2.0 0.984126984126984 COG3239 Fatty_acid_desaturase DesA 63.0 0.0 1.0 0.0011002212559437 0.0051938381547582 0.0031470297053509 0.0040936168988145 0 0 0 0 K00514 0.02 0.0626780626780626 ZDS, crtQ; zeta-carotene desaturase [EC:1.3.5.6] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 140.0 19.0 11.0 5.0 0.612903225806452 S 8.0 23.0 3.0 0.548387096774194 COG3349 Uncharacterized_protein,_contains_NAD-binding_domain_and_a_Fe-S_cluster 31.0 0.2580645161290322 0.7419354838709677 0.0094294555418547 0.0041609948133494 0.006795225177602 0.0052684607285052 0 0 0 0 K00515 0.0114285714285714 0.0 BCMO1, BCDO1; beta-carotene 15,15'-dioxygenase [EC:1.13.11.63] path:map00830,path:map01100,path:map01240 Retinol metabolism,Metabolic pathways,Biosynthesis of cofactors 454.0 5.0 0.0 1.0 1.0 Q 5.0 0.0 1.0 1.0 COG3670 Carotenoid_cleavage_dioxygenase_or_a_related_enzyme 5.0 1.0 0.0 0.0062305245092879 0.0177710155511633 0.0120007700302256 0.0115404910418753 0 0 0 0 K00518 0.0314285714285714 0.1111111111111111 sodN; nickel superoxide dismutase [EC:1.15.1.1] 106.0 45.0 42.0 3.0 0.882352941176471 S 12.0 39.0 2.0 0.784313725490196 293MU 51.0 0.2352941176470588 0.7647058823529411 0.055098875280714 0.949588273072362 0.5023435741765381 0.894489397791648 0 0 0 0 K00520 0.1257142857142857 0.1709401709401709 merA; mercuric reductase [EC:1.16.1.1] 335.0 121.0 119.0 2.0 0.983739837398374 C 52.0 71.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 123.0 0.4227642276422764 0.5772357723577236 0.203364653738348 0.710604370937329 0.4569845123378385 0.507239717198981 0 0 0 0 K00523 0.0628571428571428 0.1396011396011396 ascD, ddhD, rfbI; CDP-4-dehydro-6-deoxyglucose reductase, E3 [EC:1.17.1.1] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 49.0 83.0 80.0 3.0 0.954022988505747 C 22.0 59.0 6.0 0.425287356321839 COG0543 NAD(P)H-flavin_reductase Mcr1 81.0 0.2716049382716049 0.7283950617283951 0.0166607658172628 0.0221319533699944 0.0193963595936286 0.0054711875527315 0 0 0 0 K00524 0.0 0.0 nrdJ; ribonucleotide reductase, class II [EC:1.17.4.2] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 11.0 7.0 3.0 0.647058823529412 L 0.0 0.0 2.0 0.764705882352941 COG1372 Intein/homing_endonuclease Hop 0.0 0 0 0 0 K00525 0.7457142857142857 0.8518518518518519 E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 183.0 745.0 725.0 7.0 0.947837150127226 F 337.0 445.0 11.0 0.947837150127226 COG0209 Ribonucleotide_reductase_alpha_subunit NrdA 782.0 0.4309462915601023 0.5690537084398977 0.823349624851666 0.951329356968553 0.8873394909101096 0.127979732116887 1 1 1 1 K00526 0.1142857142857142 0.4387464387464387 E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 100.0 230.0 226.0 4.0 0.966386554621849 F 59.0 178.0 4.0 0.970588235294118 COG0208 Ribonucleotide_reductase_beta_subunit,_ferritin-like_domain NrdB 237.0 0.2489451476793249 0.7510548523206751 0.0125089010989705 0.343985476102446 0.1782471886007082 0.3314765750034755 0 0 0 0 K00528 0.2257142857142857 0.5071225071225072 fpr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1] 46.0 259.0 220.0 4.0 0.768545994065282 C 105.0 229.0 9.0 0.58160237388724 COG0543 NAD(P)H-flavin_reductase Mcr1 334.0 0.3143712574850299 0.6856287425149701 0.613676883369427 0.544044761810377 0.578860822589902 0.06963212155905 0 1 0 1 K00529 0.14 0.1851851851851851 hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3] path:map00071,path:map00360,path:map01100,path:map01120,path:map01220 Fatty acid degradation,Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 166.0 105.0 58.0 4.0 0.532994923857868 S 91.0 106.0 6.0 0.771573604060914 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 197.0 0.4619289340101523 0.5380710659898477 0.0053278163397453 0.0928501423184715 0.0490889793291084 0.0875223259787262 0 0 0 0 K00531 0.0057142857142857 0.0056980056980056 anfG; nitrogenase delta subunit [EC:1.18.6.1] path:map00625,path:map00910,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 116.0 3.0 2.0 2.0 0.75 C 2.0 2.0 1.0 1.0 arCOG03983 4.0 0.5 0.5 0.158581409584163 0.245589115576802 0.2020852625804824 0.0870077059926389 0 0 0 0 K00532 0.0 0.0056980056980056 E1.12.7.2; ferredoxin hydrogenase [EC:1.12.7.2] 562.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 2.0 0.0 1.0 0 0 0 0 K00533 0.0028571428571428 0.0683760683760683 E1.12.7.2L; ferredoxin hydrogenase large subunit [EC:1.12.7.2] 200.0 28.0 0.0 1.0 1.0 C 1.0 27.0 9.0 0.321428571428571 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 28.0 0.0357142857142857 0.9642857142857144 0.0467558514250314 0.177274369015735 0.1120151102203832 0.1305185175907036 0 0 0 0 K00534 0.0028571428571428 0.0683760683760683 E1.12.7.2S; ferredoxin hydrogenase small subunit [EC:1.12.7.2] 200.0 22.0 19.0 2.0 0.88 C 1.0 24.0 4.0 0.68 COG1740 Ni,Fe-hydrogenase_I_small_subunit HyaA 25.0 0.04 0.96 0.0221574778566685 0.125085688926165 0.0736215833914167 0.1029282110694965 0 0 0 0 K00537 0.0257142857142857 0.3874643874643874 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1] 61.0 184.0 164.0 4.0 0.880382775119617 P 9.0 200.0 3.0 0.966507177033493 COG1393 Arsenate_reductase_or_related_protein,_glutaredoxin_family ArsC 209.0 0.0430622009569378 0.9569377990430622 0.0017065676734854 0.0075033420628479 0.0046049548681666 0.0057967743893625 0 0 0 0 K00543 0.0 0.0199430199430199 ASMT; acetylserotonin O-methyltransferase [EC:2.1.1.4] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 179.0 7.0 0.0 1.0 1.0 J 0.0 7.0 2.0 0.857142857142857 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 7.0 0.0 1.0 0.367857884180643 0.437499105405964 0.4026784947933035 0.0696412212253209 0 0 0 0 K00544 0.0057142857142857 0.0683760683760683 BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5] path:map00260,path:map00270,path:map01100,path:map01110 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 254.0 30.0 28.0 2.0 0.9375 E 2.0 29.0 1.0 1.0 COG0646 Methionine_synthase_I_(cobalamin-dependent),_methyltransferase_domain MetH1 31.0 0.064516129032258 0.935483870967742 0.0314745988326763 0.109537895526276 0.0705062471794761 0.0780632966935997 0 0 0 0 K00545 0.0028571428571428 0.0085470085470085 COMT; catechol O-methyltransferase [EC:2.1.1.6] path:map00140,path:map00350,path:map00965,path:map01100,path:map04728 Steroid hormone biosynthesis,Tyrosine metabolism,Betalain biosynthesis,Metabolic pathways,Dopaminergic synapse 175.0 3.0 1.0 2.0 0.6 E 1.0 4.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 5.0 0.2 0.8 0.0402953392804661 0.230373480172089 0.1353344097262775 0.1900781408916229 0 0 0 0 K00547 0.0 0.0 mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10] path:map00270,path:map01100,path:map01110 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 110.0 64.0 2.0 0.705128205128205 E 0.0 0.0 3.0 0.384615384615385 COG0646 Methionine_synthase_I_(cobalamin-dependent),_methyltransferase_domain MetH1 0.0 0 0 0 0 K00548 0.0 0.0 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] path:map00270,path:map00450,path:map00670,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Selenocompound metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 320.0 209.0 5.0 0.606060606060606 E 0.0 0.0 5.0 0.573863636363636 COG0646 Methionine_synthase_I_(cobalamin-dependent),_methyltransferase_domain MetH1 0.0 0 0 0 0 K00549 0.5428571428571428 0.3903133903133903 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14] path:map00270,path:map00450,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Selenocompound metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 61.0 478.0 444.0 3.0 0.893457943925234 E 322.0 210.0 2.0 0.957009345794393 COG0620 Methionine_synthase_II_(cobalamin-independent) MetE 532.0 0.6052631578947368 0.3947368421052631 0.598646229138884 0.737956314293859 0.6683012717163714 0.139310085154975 0 1 0 1 K00550 0.0 0.0028490028490028 PLMT; phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71] path:map00564,path:map01100,path:map01110 Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 178.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 2A9IB 1.0 0.0 1.0 0 0 0 0 K00554 0.0 0.98005698005698 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] 159.0 350.0 344.0 4.0 0.972222222222222 J 0.0 360.0 4.0 0.969444444444444 COG0336 tRNA_G37_N-methylase_TrmD TrmD 360.0 0.0 1.0 0.666370702338775 0.65640531612438 0.6613880092315776 0.009965386214395 0 0 0 1 K00555 0.8257142857142857 0.0142450142450142 TRMT1, trm1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216] 178.0 299.0 298.0 2.0 0.996666666666667 J 295.0 5.0 1.0 1.0 COG1867 tRNA_G26_N,N-dimethylase_Trm1 TRM1 300.0 0.9833333333333332 0.0166666666666666 0.937197100717884 0.958336357543008 0.947766729130446 0.021139256825124 1 1 1 1 K00556 0.0057142857142857 0.2535612535612536 trmH; tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34] 84.0 104.0 103.0 2.0 0.99047619047619 J 2.0 103.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 105.0 0.019047619047619 0.9809523809523808 0.0144663440013013 0.0593787570956457 0.0369225505484735 0.0449124130943444 0 0 0 0 K00557 0.0571428571428571 0.1623931623931624 trmA; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35] 165.0 77.0 73.0 2.0 0.950617283950617 J 20.0 61.0 1.0 1.0 COG2265 tRNA/tmRNA/rRNA_uracil-C5-methylase,_TrmA/RlmC/RlmD_family TrmA 81.0 0.2469135802469135 0.7530864197530864 0.0169387128036743 0.645407480618834 0.3311730967112541 0.6284687678151597 0 0 0 0 K00558 0.3342857142857143 0.4415954415954416 DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] path:map00270,path:map01100,path:map05206 Cysteine and methionine metabolism,Metabolic pathways,MicroRNAs in cancer 5.0 270.0 17.0 5.0 0.497237569060774 H 152.0 320.0 11.0 0.931860036832412 COG0270 DNA-cytosine_methylase Dcm 472.0 0.3220338983050847 0.6779661016949152 0.0274419497206735 0.0888717081119381 0.0581568289163058 0.0614297583912646 0 0 0 0 K00559 0.0028571428571428 0.0056980056980056 SMT1, ERG6; sterol 24-C-methyltransferase [EC:2.1.1.41] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 265.0 3.0 0.0 1.0 1.0 Q 1.0 2.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K00560 0.4542857142857143 0.5698005698005698 thyA, TYMS; thymidylate synthase [EC:2.1.1.45] path:map00240,path:map00670,path:map01100,path:map01232,path:map01523 Pyrimidine metabolism,One carbon pool by folate,Metabolic pathways,Nucleotide metabolism,Antifolate resistance 65.0 352.0 321.0 3.0 0.875621890547264 F 176.0 229.0 8.0 0.854320987654321 COG0207 Thymidylate_synthase ThyA 405.0 0.4345679012345679 0.5654320987654321 0.0418783065114143 0.200594064326957 0.1212361854191856 0.1587157578155427 0 0 0 0 K00561 0.0 0.0769230769230769 ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184] 120.0 29.0 0.0 1.0 1.0 J 0.0 29.0 1.0 1.0 COG0030 16S_rRNA_A1518_and_A1519_N6-dimethyltransferase_RsmA/KsgA/DIM1_(may_also_have_DNA_glycosylase/AP_lyase_activity) RsmA 29.0 0.0 1.0 0.568866708833347 0.757265040366888 0.6630658746001175 0.188398331533541 0 0 0 1 K00563 0.0028571428571428 0.1709401709401709 rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187] 82.0 52.0 47.0 5.0 0.787878787878788 Q 1.0 65.0 5.0 0.863636363636364 COG0500 SAM-dependent_methyltransferase SmtA 66.0 0.0151515151515151 0.9848484848484848 0.0008219608455659 0.0011337476343298 0.0009778542399478 0.0003117867887638 0 0 0 0 K00564 0.0771428571428571 0.2336182336182336 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172] 64.0 100.0 82.0 7.0 0.78740157480315 J 27.0 100.0 5.0 0.795275590551181 COG2813 16S_rRNA_G1207_methylase_RsmC RsmC 127.0 0.2125984251968504 0.7874015748031497 0.458320947538173 0.530657406873255 0.494489177205714 0.072336459335082 0 0 0 0 K00566 0.0428571428571428 0.9572649572649572 mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] path:map04122 Sulfur relay system 135.0 378.0 373.0 4.0 0.969230769230769 J 16.0 374.0 3.0 0.969230769230769 COG0482 tRNA_U34_2-thiouridine_synthase_MnmA/TrmU,_contains_the_PP-loop_ATPase_domain MnmA 390.0 0.041025641025641 0.958974358974359 0.0449276184486055 0.0548482130294738 0.0498879157390396 0.0099205945808682 0 0 0 0 K00567 0.7542857142857143 0.7692307692307693 ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 27.0 551.0 495.0 7.0 0.789398280802292 L 308.0 390.0 6.0 0.915472779369628 COG0350 DNA_repair_enzyme_Ada_(O6-methylguanine-DNA--protein-cysteine_methyltransferase) AdaB 698.0 0.4412607449856733 0.5587392550143266 0.230364943671403 0.173714347297479 0.202039645484441 0.056650596373924 0 0 0 0 K00568 0.0971428571428571 0.396011396011396 ubiG; 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.222 2.1.1.64] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 5.0 208.0 197.0 7.0 0.838709677419355 H 38.0 186.0 11.0 0.818548387096774 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 224.0 0.1696428571428571 0.8303571428571429 0.197118877183261 0.674527022850614 0.4358229500169375 0.477408145667353 0 0 0 0 K00569 0.02 0.1168091168091168 TPMT, tpmT; thiopurine S-methyltransferase [EC:2.1.1.67] path:map00983 Drug metabolism - other enzymes 104.0 41.0 37.0 3.0 0.854166666666667 Q 7.0 41.0 2.0 0.979166666666667 COG0500 SAM-dependent_methyltransferase SmtA 48.0 0.1458333333333333 0.8541666666666666 0.0012544283313184 0.0043545139823012 0.0028044711568098 0.0031000856509828 0 0 0 0 K00570 0.0142857142857142 0.0797720797720797 pmtA; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71] path:map00564,path:map01100,path:map01110 Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 118.0 27.0 13.0 3.0 0.642857142857143 Q 5.0 37.0 2.0 0.666666666666667 COG0500 SAM-dependent_methyltransferase SmtA 42.0 0.119047619047619 0.8809523809523809 0.0015800200664557 0.0051757504725812 0.0033778852695184 0.0035957304061254 0 0 0 0 K00571 0.3314285714285714 0.4273504273504273 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 6.0 433.0 359.0 11.0 0.793040293040293 L 210.0 277.0 16.0 0.545787545787546 COG0863 DNA_modification_methylase YhdJ 487.0 0.4312114989733059 0.5687885010266941 0.720121191365318 0.643715576289149 0.6819183838272336 0.076405615076169 0 1 0 1 K00573 0.6942857142857143 0.5925925925925926 E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] 31.0 304.0 49.0 7.0 0.504145936981758 J 296.0 304.0 5.0 0.970149253731343 COG2518 Protein-L-isoaspartate_O-methyltransferase Pcm 600.0 0.4933333333333333 0.5066666666666667 0.170623636518747 0.167541351444903 0.169082493981825 0.003082285073844 0 0 0 0 K00574 0.0914285714285714 0.4615384615384615 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79] 39.0 240.0 189.0 4.0 0.747663551401869 M 38.0 280.0 6.0 0.763239875389408 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 318.0 0.1194968553459119 0.8805031446540881 0.0099314455078166 0.0847328663265662 0.0473321559171914 0.0748014208187495 0 0 0 0 K00575 0.2371428571428571 0.4672364672364672 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80] path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 61.0 279.0 200.0 8.0 0.635535307517084 NT 103.0 336.0 10.0 0.888382687927107 COG1352 Methylase_of_chemotaxis_methyl-accepting_proteins CheR 439.0 0.2346241457858769 0.765375854214123 0.0914198694976345 0.18808443886368 0.1397521541806572 0.0966645693660455 0 0 0 0 K00577 0.1885714285714285 0.0056980056980056 mtrA; tetrahydromethanopterin S-methyltransferase subunit A [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 147.0 102.0 0.0 1.0 1.0 H 100.0 2.0 1.0 1.0 COG4063 Tetrahydromethanopterin_S-methyltransferase,_subunit_A MtrA 102.0 0.9803921568627452 0.0196078431372549 0.0169611859363776 0.280661499255801 0.1488113425960892 0.2637003133194234 0 0 0 0 K00578 0.12 0.0 mtrB; tetrahydromethanopterin S-methyltransferase subunit B [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 98.0 43.0 0.0 1.0 1.0 H 43.0 0.0 1.0 1.0 COG4062 Tetrahydromethanopterin_S-methyltransferase,_subunit_B MtrB 43.0 1.0 0.0 0.0032525939215043 0.0034827336141653 0.0033676637678348 0.0002301396926609 0 0 0 0 K00579 0.12 0.0 mtrC; tetrahydromethanopterin S-methyltransferase subunit C [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 237.0 43.0 0.0 1.0 1.0 H 43.0 0.0 1.0 1.0 COG4061 Tetrahydromethanopterin_S-methyltransferase,_subunit_C MtrC 43.0 1.0 0.0 0.0021098385072297 0.0062616237743521 0.0041857311407909 0.0041517852671224 0 0 0 0 K00580 0.12 0.0 mtrD; tetrahydromethanopterin S-methyltransferase subunit D [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 218.0 44.0 0.0 1.0 1.0 H 44.0 0.0 1.0 1.0 COG4060 Tetrahydromethanopterin_S-methyltransferase,_subunit_D MtrD 44.0 1.0 0.0 0.0007762857990382 0.0032854054454877 0.0020308456222629 0.0025091196464495 0 0 0 0 K00581 0.12 0.0 mtrE; tetrahydromethanopterin S-methyltransferase subunit E [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 276.0 43.0 0.0 1.0 1.0 H 43.0 0.0 1.0 1.0 COG4059 Tetrahydromethanopterin_S-methyltransferase,_subunit_E MtrE 43.0 1.0 0.0 0.00049277990233 0.0013449824661998 0.0009188811842649 0.0008522025638697 0 0 0 0 K00582 0.0885714285714285 0.0 mtrF; tetrahydromethanopterin S-methyltransferase subunit F [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 61.0 31.0 0.0 1.0 1.0 H 31.0 0.0 1.0 1.0 COG4218 Tetrahydromethanopterin_S-methyltransferase,_subunit_F MtrF 31.0 1.0 0.0 0.0019813917391206 0.0028858301103495 0.002433610924735 0.0009044383712289 0 0 0 0 K00583 0.08 0.0 mtrG; tetrahydromethanopterin S-methyltransferase subunit G [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 65.0 28.0 0.0 1.0 1.0 H 28.0 0.0 1.0 1.0 COG4064 Tetrahydromethanopterin_S-methyltransferase,_subunit_G MtrG 28.0 1.0 0.0 0.0021382395604241 0.0056053758847713 0.0038718077225977 0.0034671363243471 0 0 0 0 K00584 0.2342857142857143 0.0056980056980056 mtrH; tetrahydromethanopterin S-methyltransferase subunit H [EC:2.1.1.86] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 253.0 130.0 0.0 1.0 1.0 H 128.0 2.0 1.0 1.0 COG1962 Tetrahydromethanopterin_S-methyltransferase,_subunit_H MtrH 130.0 0.9846153846153848 0.0153846153846153 0.970152499303458 0.996002891947089 0.9830776956252736 0.0258503926436309 0 0 1 1 K00586 0.1 0.0 DPH5; diphthine methyl ester synthase [EC:2.1.1.314] 203.0 35.0 0.0 1.0 1.0 J 35.0 0.0 1.0 1.0 COG1798 Diphthamide_biosynthesis_methyltransferase DPH5 35.0 1.0 0.0 0.56269611445771 0.492794944358302 0.527745529408006 0.0699011700994079 0 0 0 1 K00587 0.0228571428571428 0.0313390313390313 ICMT, STE14; protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 127.0 19.0 0.0 1.0 1.0 O 8.0 11.0 1.0 1.0 COG2020 Protein-S-isoprenylcysteine_O-methyltransferase_Ste14 STE14 19.0 0.4210526315789473 0.5789473684210527 0.211765048753655 0.299003281067377 0.255384164910516 0.0872382323137219 0 0 0 0 K00588 0.0171428571428571 0.2592592592592592 E2.1.1.104; caffeoyl-CoA O-methyltransferase [EC:2.1.1.104] path:map00940,path:map00941,path:map00945,path:map01100,path:map01110 Phenylpropanoid biosynthesis,Flavonoid biosynthesis,Stilbenoid, diarylheptanoid and gingerol biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 158.0 93.0 85.0 4.0 0.853211009174312 S 7.0 103.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 110.0 0.0636363636363636 0.9363636363636364 0.0088619246409707 0.773971619378132 0.3914167720095513 0.7651096947371613 0 0 0 0 K00590 0.4942857142857143 0.301994301994302 E2.1.1.113; site-specific DNA-methyltransferase (cytosine-N4-specific) [EC:2.1.1.113] 5.0 539.0 498.0 5.0 0.916666666666667 L 335.0 213.0 5.0 0.974489795918367 COG0863 DNA_modification_methylase YhdJ 548.0 0.6113138686131386 0.3886861313868613 0.818500483067755 0.582656429128248 0.7005784560980015 0.235844053939507 1 1 1 1 K00591 0.0 0.0056980056980056 COQ3; polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC:2.1.1.114 2.1.1.64] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 327.0 2.0 0.0 1.0 1.0 H 0.0 2.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 2.0 0.0 1.0 0 0 0 0 K00594 0.0 0.0712250712250712 xyoA, aldO; alditol oxidase [EC:1.1.3.41] path:map00040,path:map00051,path:map01100 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways 349.0 29.0 0.0 1.0 1.0 C 0.0 29.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 29.0 0.0 1.0 0.0266463794574233 0.0702638457350549 0.048455112596239 0.0436174662776316 0 0 0 0 K00595 0.0514285714285714 0.3333333333333333 cobL-cbiET; precorrin-6B C5,15-methyltransferase / cobalt-precorrin-6B C5,C15-methyltransferase [EC:2.1.1.132 2.1.1.289 2.1.1.196] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 116.0 168.0 164.0 2.0 0.976744186046512 H 20.0 145.0 3.0 0.726744186046512 COG2241 Precorrin-6B_methylase_1 CobL 165.0 0.1212121212121212 0.8787878787878788 0.0101408078636554 0.0360530530685247 0.02309693046609 0.0259122452048693 0 0 0 0 K00596 0.0 0.0256410256410256 E4.1.1.64; 2,2-dialkylglycine decarboxylase (pyruvate) [EC:4.1.1.64] 423.0 8.0 5.0 2.0 0.727272727272727 E 0.0 11.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 11.0 0.0 1.0 0.0610289292482867 0.0994774505859518 0.0802531899171192 0.0384485213376651 0 0 0 0 K00598 0.0257142857142857 0.1481481481481481 tam; trans-aconitate 2-methyltransferase [EC:2.1.1.144] 132.0 45.0 32.0 5.0 0.633802816901409 S 10.0 61.0 2.0 0.929577464788732 COG4106 Trans-aconitate_methyltransferase Tam 71.0 0.1408450704225352 0.8591549295774648 0.0654592899925159 0.835289647650389 0.4503744688214525 0.7698303576578731 0 0 0 0 K00600 0.7685714285714286 0.9487179487179488 glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] path:map00260,path:map00460,path:map00630,path:map00670,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map01240,path:map01523 Glycine, serine and threonine metabolism,Cyanoamino acid metabolism,Glyoxylate and dicarboxylate metabolism,One carbon pool by folate,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors,Antifolate resistance 292.0 682.0 654.0 3.0 0.952513966480447 E 320.0 396.0 1.0 1.0 COG0112 Glycine/serine_hydroxymethyltransferase GlyA 716.0 0.4469273743016759 0.553072625698324 0.410004475064461 0.90166955345478 0.6558370142596205 0.4916650783903189 0 0 0 0 K00602 0.2857142857142857 0.8660968660968661 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] path:map00230,path:map00670,path:map01100,path:map01110,path:map01523 Purine metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites,Antifolate resistance 339.0 439.0 0.0 1.0 1.0 F 107.0 332.0 2.0 0.997722095671982 COG0138 AICAR_transformylase/IMP_cyclohydrolase_PurH PurH 439.0 0.2437357630979499 0.7562642369020501 0.184514971784395 0.198510818350254 0.1915128950673245 0.013995846565859 0 0 0 0 K00603 0.1171428571428571 0.1851851851851851 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] path:map00340,path:map00670,path:map01100 Histidine metabolism,One carbon pool by folate,Metabolic pathways 260.0 118.0 0.0 1.0 1.0 E 45.0 73.0 2.0 0.542372881355932 COG3643 Glutamate_formiminotransferase GluFT 118.0 0.3813559322033898 0.6186440677966102 0.205290140150544 0.890537083215865 0.5479136116832045 0.685246943065321 0 0 0 0 K00604 0.0971428571428571 0.9629629629629628 MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9] path:map00670,path:map00970,path:map01100 One carbon pool by folate,Aminoacyl-tRNA biosynthesis,Metabolic pathways 69.0 432.0 422.0 6.0 0.957871396895787 J 35.0 416.0 7.0 0.960088691796009 COG0223 Methionyl-tRNA_formyltransferase Fmt 451.0 0.0776053215077605 0.9223946784922394 0.0461517833443384 0.781030455325587 0.4135911193349627 0.7348786719812486 0 0 0 0 K00605 0.3942857142857143 0.698005698005698 gcvT, AMT; aminomethyltransferase [EC:2.1.2.10] path:map00260,path:map00630,path:map00670,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 113.0 430.0 359.0 3.0 0.826923076923077 E 191.0 326.0 3.0 0.948076923076923 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 517.0 0.3694390715667311 0.6305609284332688 0.0388654391983411 0.570361379283287 0.304613409240814 0.5314959400849459 0 0 0 0 K00606 0.36 0.717948717948718 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] path:map00770,path:map01100,path:map01110,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 215.0 397.0 0.0 1.0 1.0 H 128.0 269.0 1.0 1.0 COG0413 Ketopantoate_hydroxymethyltransferase PanB 397.0 0.3224181360201511 0.6775818639798489 0.0888104583168025 0.65584886048427 0.3723296594005362 0.5670384021674676 0 0 0 0 K00608 0.0 0.0826210826210826 pyrBI; aspartate carbamoyltransferase [EC:2.1.3.2] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 284.0 29.0 0.0 1.0 1.0 F 0.0 29.0 1.0 1.0 COG0540 Aspartate_carbamoyltransferase,_catalytic_subunit PyrB 29.0 0.0 1.0 0.9542968174067 0.148415043064172 0.551355930235436 0.8058817743425281 0 0 1 1 K00609 0.7571428571428571 0.8490028490028491 pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 188.0 574.0 569.0 3.0 0.989655172413793 F 271.0 309.0 2.0 0.989655172413793 COG0540 Aspartate_carbamoyltransferase,_catalytic_subunit PyrB 580.0 0.4672413793103448 0.5327586206896552 0.540125359050066 0.093111769590464 0.316618564320265 0.447013589459602 0 1 0 1 K00610 0.6971428571428572 0.0883190883190883 pyrI; aspartate carbamoyltransferase regulatory subunit path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 118.0 277.0 0.0 1.0 1.0 F 246.0 31.0 1.0 1.0 COG1781 Aspartate_carbamoyltransferase,_regulatory_subunit PyrI 277.0 0.8880866425992779 0.111913357400722 0.80580101506049 0.82592502071837 0.8158630178894299 0.02012400565788 1 1 1 1 K00611 0.7171428571428572 0.7578347578347578 OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3] path:map00220,path:map01100,path:map01110,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 185.0 550.0 536.0 2.0 0.975177304964539 E 268.0 296.0 2.0 0.599290780141844 COG0078 Ornithine_carbamoyltransferase ArgF 564.0 0.475177304964539 0.524822695035461 0.749280894711449 0.453716817536301 0.601498856123875 0.295564077175148 0 1 0 1 K00612 0.1542857142857142 0.2222222222222222 nodU; carbamoyltransferase [EC:2.1.3.-] 277.0 171.0 160.0 4.0 0.914438502673797 O 69.0 118.0 5.0 0.93048128342246 COG2192 Predicted_carbamoyl_transferase,_NodU_family 187.0 0.3689839572192513 0.6310160427807486 0.174600070301671 0.520459527688523 0.347529798995097 0.345859457386852 0 0 0 0 K00613 0.0057142857142857 0.0313390313390313 GATM; glycine amidinotransferase [EC:2.1.4.1] path:map00260,path:map00330,path:map01100 Glycine, serine and threonine metabolism,Arginine and proline metabolism,Metabolic pathways 327.0 13.0 12.0 2.0 0.928571428571429 E 2.0 12.0 1.0 1.0 COG1834 N-Dimethylarginine_dimethylaminohydrolase DdaH 14.0 0.1428571428571428 0.8571428571428571 0.0788741692692756 0.239947664540928 0.1594109169051017 0.1610734952716524 0 0 0 0 K00615 0.0 0.0 E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1] path:map00030,path:map00710,path:map01051,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Carbon fixation in photosynthetic organisms,Biosynthesis of ansamycins,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 924.0 889.0 3.0 0.942857142857143 G 0.0 0.0 7.0 0.354081632653061 COG0021 Transketolase TktA 0.0 0 0 0 0 K00616 0.2628571428571428 0.7549857549857549 E2.2.1.2, talA, talB; transaldolase [EC:2.2.1.2] path:map00030,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 146.0 221.0 100.0 3.0 0.508045977011494 G 100.0 335.0 3.0 0.977011494252874 COG0176 Transaldolase/fructose-6-phosphate_aldolase TalA 435.0 0.2298850574712643 0.7701149425287356 0.572069568554979 0.863820450756434 0.7179450096557065 0.2917508822014549 0 1 0 1 K00619 0.1314285714285714 0.2877492877492877 argA; amino-acid N-acetyltransferase [EC:2.3.1.1] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 42.0 138.0 122.0 6.0 0.766666666666667 E 68.0 112.0 5.0 0.822222222222222 COG1246 N-acetylglutamate_synthase_or_related_acetyltransferase,_GNAT_family ArgA 180.0 0.3777777777777777 0.6222222222222222 0.0253470746304876 0.0589961042949952 0.0421715894627414 0.0336490296645076 0 0 0 0 K00620 0.2228571428571428 0.6182336182336182 argJ; glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 216.0 298.0 287.0 2.0 0.964401294498382 E 79.0 230.0 2.0 0.996763754045308 COG1364 Glutamate_N-acetyltransferase_(ornithine_transacetylase) ArgJ 309.0 0.255663430420712 0.7443365695792881 0.062570668038321 0.0606642159461692 0.0616174419922451 0.0019064520921517 0 0 0 0 K00621 0.0428571428571428 0.0056980056980056 GNPNAT1, GNA1; glucosamine-phosphate N-acetyltransferase [EC:2.3.1.4] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 127.0 20.0 0.0 1.0 1.0 K 18.0 2.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 20.0 0.9 0.1 0.0044981275530933 0.0072668866857325 0.0058825071194129 0.0027687591326392 0 0 0 0 K00622 0.0 0.0085470085470085 nat; arylamine N-acetyltransferase [EC:2.3.1.5] path:map00232,path:map00633,path:map00983,path:map01100,path:map01110,path:map01120,path:map05204 Caffeine metabolism,Nitrotoluene degradation,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Chemical carcinogenesis - DNA adducts 233.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG2162 Arylamine_N-acetyltransferase NhoA 3.0 0.0 1.0 0 0 0 0 K00624 0.0 0.0142450142450142 E2.3.1.7; carnitine O-acetyltransferase [EC:2.3.1.7] path:map04146 Peroxisome 542.0 3.0 2.0 3.0 0.6 S 0.0 5.0 1.0 1.0 28HC8 5.0 0.0 1.0 0.0886141629872344 0.196622799738677 0.1426184813629556 0.1080086367514426 0 0 0 0 K00625 0.04 0.3504273504273504 pta; phosphate acetyltransferase [EC:2.3.1.8] path:map00430,path:map00620,path:map00640,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Taurine and hypotaurine metabolism,Pyruvate metabolism,Propanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 201.0 136.0 122.0 3.0 0.839506172839506 C 14.0 147.0 1.0 1.0 COG0280 Phosphotransacetylase_(includes_Pta,_EutD_and_phosphobutyryltransferase) Pta 161.0 0.0869565217391304 0.9130434782608696 0.0100928537089078 0.0624356399600352 0.0362642468344715 0.0523427862511274 0 0 0 0 K00626 0.7857142857142857 0.6267806267806267 ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] path:map00071,path:map00280,path:map00310,path:map00362,path:map00380,path:map00620,path:map00630,path:map00650,path:map00720,path:map00900,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212,path:map02020,path:map04975 Fatty acid degradation,Valine, leucine and isoleucine degradation,Lysine degradation,Benzoate degradation,Tryptophan metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism,Two-component system,Fat digestion and absorption 65.0 1632.0 1627.0 3.0 0.995121951219512 I 852.0 788.0 3.0 0.992073170731707 COG0183 Acetyl-CoA_acetyltransferase PaaJ 1640.0 0.5195121951219512 0.4804878048780487 0 0 0 0 K00627 0.3828571428571428 0.6609686609686609 DLAT, aceF, pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] path:map00010,path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 133.0 524.0 469.0 7.0 0.885135135135135 C 179.0 413.0 9.0 0.886824324324324 COG0508 Pyruvate/2-oxoglutarate_dehydrogenase_complex,_dihydrolipoamide_acyltransferase_(E2)_component AceF 592.0 0.3023648648648648 0.6976351351351351 0.398202952382689 0.808454639263288 0.6033287958229885 0.410251686880599 0 0 0 0 K00630 0.0 0.0085470085470085 ATS1; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] path:map00561,path:map00564,path:map01100 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways 231.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 3.0 0.0 1.0 0 0 0 0 K00631 0.0057142857142857 0.1111111111111111 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15] path:map00561,path:map00564,path:map01100,path:map01110 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 242.0 42.0 41.0 2.0 0.976744186046512 I 2.0 41.0 2.0 0.930232558139535 COG2937 Glycerol-3-phosphate_O-acyltransferase PlsB 43.0 0.0465116279069767 0.9534883720930232 0.0010322110946742 0.0049204922285694 0.0029763516616218 0.0038882811338952 0 0 0 0 K00632 0.3571428571428571 0.4301994301994302 fadA, fadI; acetyl-CoA acyltransferase [EC:2.3.1.16] path:map00071,path:map00280,path:map00281,path:map00362,path:map00592,path:map00642,path:map01100,path:map01110,path:map01120,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,Geraniol degradation,Benzoate degradation,alpha-Linolenic acid metabolism,Ethylbenzene degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Fatty acid metabolism 211.0 600.0 0.0 1.0 1.0 I 309.0 291.0 2.0 0.998333333333333 COG0183 Acetyl-CoA_acetyltransferase PaaJ 600.0 0.515 0.485 0.0945723292724884 0.346234587206618 0.2204034582395532 0.2516622579341295 0 0 0 0 K00633 0.0028571428571428 0.0797720797720797 lacA; galactoside O-acetyltransferase [EC:2.3.1.18] 140.0 27.0 25.0 5.0 0.84375 S 1.0 31.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 32.0 0.03125 0.96875 0.0220889642941864 0.0939626724332761 0.0580258183637312 0.0718737081390897 0 0 0 0 K00634 0.0057142857142857 0.225071225071225 ptb; phosphate butyryltransferase [EC:2.3.1.19] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 224.0 95.0 84.0 6.0 0.785123966942149 C 3.0 118.0 4.0 0.942148760330578 COG0280 Phosphotransacetylase_(includes_Pta,_EutD_and_phosphobutyryltransferase) Pta 121.0 0.024793388429752 0.975206611570248 0.568235719382354 0.512269913799936 0.540252816591145 0.0559658055824179 0 0 0 1 K00635 0.0 0.0427350427350427 tgs, wax-dgat; diacylglycerol O-acyltransferase / wax synthase [EC:2.3.1.20 2.3.1.75] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 357.0 15.0 2.0 3.0 0.517241379310345 Q 0.0 29.0 2.0 0.96551724137931 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 29.0 0.0 1.0 0.0002652925198916 0.0007982232644703 0.0005317578921809 0.0005329307445787 0 0 0 0 K00638 0.02 0.0455840455840455 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28] 90.0 16.0 7.0 3.0 0.551724137931034 S 9.0 19.0 2.0 0.689655172413793 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 28.0 0.3214285714285714 0.6785714285714286 0.0092208844277856 0.023765495468714 0.0164931899482498 0.0145446110409283 0 0 0 0 K00639 0.26 0.5071225071225072 kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 272.0 216.0 68.0 3.0 0.591780821917808 H 97.0 268.0 1.0 1.0 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 365.0 0.2657534246575342 0.7342465753424657 0.490090626219799 0.869088784188269 0.679589705204034 0.37899815796847 0 0 0 0 K00640 0.2285714285714285 0.7037037037037037 cysE; serine O-acetyltransferase [EC:2.3.1.30] path:map00270,path:map00543,path:map00920,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map05111 Cysteine and methionine metabolism,Exopolysaccharide biosynthesis,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Biofilm formation - Vibrio cholerae 85.0 402.0 394.0 5.0 0.961722488038278 E 102.0 316.0 5.0 0.961722488038278 COG1045 Serine_acetyltransferase CysE 418.0 0.2440191387559808 0.7559808612440191 0.114443249094536 0.250565187710846 0.182504218402691 0.13612193861631 0 0 0 0 K00641 0.2142857142857142 0.4074074074074074 metX; homoserine O-acetyltransferase/O-succinyltransferase [EC:2.3.1.31 2.3.1.46] path:map00270,path:map00920,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 194.0 247.0 242.0 5.0 0.968627450980392 E 85.0 170.0 6.0 0.956862745098039 COG2021 Homoserine_O-acetyltransferase MET2 255.0 0.3333333333333333 0.6666666666666666 0.02196044655288 0.0488176571619785 0.0353890518574292 0.0268572106090985 0 0 0 0 K00643 0.0 0.0883190883190883 E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37] path:map00260,path:map00860,path:map01100,path:map01110,path:map01240 Glycine, serine and threonine metabolism,Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 387.0 24.0 7.0 2.0 0.585365853658537 E 0.0 41.0 1.0 1.0 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 41.0 0.0 1.0 0.0048362661280237 0.0140649401052833 0.0094506031166535 0.0092286739772596 0 0 0 0 K00645 0.0085714285714285 0.8319088319088319 fabD, MCAT, MCT1; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] path:map00061,path:map00333,path:map01100,path:map01110,path:map01212 Fatty acid biosynthesis,Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism 180.0 319.0 316.0 2.0 0.990683229813665 I 3.0 320.0 4.0 0.984520123839009 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 323.0 0.0092879256965944 0.9907120743034056 0.0979131795788665 0.277814337162448 0.1878637583706572 0.1799011575835815 0 0 0 0 K00646 0.0 0.0199430199430199 pksF; malonyl-ACP decarboxylase 395.0 5.0 4.0 3.0 0.714285714285714 I 0.0 7.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 7.0 0.0 1.0 8.06563405794799e-13 0.0126500098654312 0.0063250049331188 0.0126500098646246 0 0 0 0 K00647 0.0 0.2193732193732193 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] path:map00061,path:map00780,path:map01100,path:map01212,path:map01240 Fatty acid biosynthesis,Biotin metabolism,Metabolic pathways,Fatty acid metabolism,Biosynthesis of cofactors 230.0 85.0 60.0 4.0 0.745614035087719 IQ 0.0 114.0 2.0 0.991228070175439 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 114.0 0.0 1.0 9.85825424452014e-05 0.0062507734498663 0.0031746779961557 0.006152190907421 0 0 0 0 K00648 0.1057142857142857 0.8233618233618234 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 126.0 527.0 519.0 3.0 0.97773654916512 I 41.0 497.0 5.0 0.946196660482375 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 538.0 0.0762081784386617 0.9237918215613384 0.0012406260845433 0.0222844872698553 0.0117625566771993 0.021043861185312 0 0 0 0 K00650 0.0 0.0085470085470085 LCAT; lecithin-cholesterol acyltransferase [EC:2.3.1.43] path:map00564,path:map04979 Glycerophospholipid metabolism,Cholesterol metabolism 236.0 3.0 0.0 1.0 1.0 KLT 0.0 3.0 1.0 1.0 COG1075 Triacylglycerol_esterase/lipase_EstA,_alpha/beta_hydrolase_fold EstA 3.0 0.0 1.0 0 0 0 0 K00651 0.0171428571428571 0.1965811965811965 metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31] path:map00270,path:map00920,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 278.0 76.0 75.0 2.0 0.987012987012987 E 6.0 71.0 3.0 0.922077922077922 COG1897 Homoserine_O-succinyltransferase MetA 77.0 0.0779220779220779 0.922077922077922 0.0045585835015254 0.120674265818992 0.0626164246602587 0.1161156823174666 0 0 0 0 K00652 0.1628571428571428 0.5270655270655271 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 211.0 145.0 9.0 6.0 0.508771929824561 H 60.0 225.0 4.0 0.989473684210526 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 285.0 0.2105263157894736 0.7894736842105263 0.859408943386586 0.712338588945279 0.7858737661659325 0.147070354441307 1 1 1 1 K00654 0.0 0.0028490028490028 SPT; serine palmitoyltransferase [EC:2.3.1.50] path:map00600,path:map01100,path:map04071,path:map04138 Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway,Autophagy - yeast 399.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 1.0 0.0 1.0 0 0 0 0 K00655 0.0 0.0 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] path:map00561,path:map00564,path:map01100,path:map01110 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 625.0 613.0 5.0 0.96749226006192 I 0.0 0.0 3.0 0.981424148606811 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 0.0 0 0 0 0 K00656 0.0857142857142857 0.2678062678062678 E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54] path:map00620,path:map00640,path:map00650,path:map01100,path:map01120 Pyruvate metabolism,Propanoate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 404.0 199.0 197.0 2.0 0.990049751243781 C 44.0 157.0 1.0 1.0 COG1882 Pyruvate-formate_lyase PflD 201.0 0.2189054726368159 0.7810945273631841 0.0409882619923856 0.346020576463761 0.1935044192280733 0.3050323144713754 0 0 0 0 K00657 0.0771428571428571 0.2108262108262108 speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57] path:map00330,path:map01100,path:map04216 Arginine and proline metabolism,Metabolic pathways,Ferroptosis 27.0 58.0 1.0 4.0 0.487394957983193 J 30.0 88.0 5.0 0.478991596638656 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 118.0 0.2542372881355932 0.7457627118644068 0.357810542772328 0.548848803882856 0.453329673327592 0.1910382611105279 0 0 0 0 K00658 0.0142857142857142 0.5156695156695157 DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] path:map00020,path:map00310,path:map00380,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Lysine degradation,Tryptophan metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 289.0 235.0 233.0 2.0 0.991561181434599 C 5.0 232.0 1.0 1.0 COG0508 Pyruvate/2-oxoglutarate_dehydrogenase_complex,_dihydrolipoamide_acyltransferase_(E2)_component AceF 237.0 0.0210970464135021 0.978902953586498 0.0707905152401845 0.27989835568264 0.1753444354614122 0.2091078404424555 0 0 0 0 K00661 0.16 0.3874643874643874 maa; maltose O-acetyltransferase [EC:2.3.1.79] 53.0 229.0 211.0 5.0 0.884169884169884 S 65.0 194.0 5.0 0.926640926640927 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 259.0 0.2509652509652509 0.749034749034749 0.0172423905959217 0.188899880445486 0.1030711355207038 0.1716574898495643 0 0 0 0 K00662 0.08 0.1025641025641025 aacC; aminoglycoside 3-N-acetyltransferase [EC:2.3.1.81] 132.0 72.0 71.0 3.0 0.972972972972973 V 28.0 46.0 1.0 1.0 COG2746 Aminoglycoside_N3'-acetyltransferase YokD 74.0 0.3783783783783784 0.6216216216216216 0.145788120785003 0.488900412240464 0.3173442665127335 0.3431122914554609 0 0 0 0 K00663 0.0028571428571428 0.0968660968660968 aacA; aminoglycoside 6'-N-acetyltransferase [EC:2.3.1.82] 81.0 41.0 38.0 3.0 0.911111111111111 J 1.0 44.0 3.0 0.911111111111111 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 45.0 0.0222222222222222 0.9777777777777776 0.0681927051334612 0.813870559284577 0.4410316322090191 0.7456778541511158 0 0 0 0 K00666 0.3742857142857143 0.4301994301994302 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-] 68.0 498.0 259.0 9.0 0.653543307086614 IQ 288.0 469.0 8.0 0.967191601049869 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 757.0 0.380449141347424 0.619550858652576 0.0214091734279308 0.0498221788906172 0.0356156761592739 0.0284130054626864 0 0 0 0 K00667 0.0057142857142857 0.0056980056980056 FAS2; fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 117.0 3.0 2.0 2.0 0.75 Q 2.0 2.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 4.0 0.5 0.5 0.0071762731798056 0.0291094346743539 0.0181428539270797 0.0219331614945482 0 0 0 0 K00668 0.0057142857142857 0.0056980056980056 FAS1; fatty acid synthase subunit beta, fungi type [EC:2.3.1.86] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 117.0 3.0 2.0 2.0 0.75 Q 2.0 2.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 4.0 0.5 0.5 0.0072661762609301 0.0290530988924036 0.0181596375766668 0.0217869226314735 0 0 0 0 K00670 0.0085714285714285 0.0056980056980056 NAA30, MAK3; N-alpha-acetyltransferase 30 [EC:2.3.1.256] 135.0 3.0 1.0 2.0 0.6 K 3.0 2.0 2.0 0.6 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 5.0 0.6 0.4 0.0679788104848204 0.145472377883323 0.1067255941840717 0.0774935673985026 0 0 0 0 K00672 0.2457142857142857 0.0284900284900284 ftr; formylmethanofuran--tetrahydromethanopterin N-formyltransferase [EC:2.3.1.101] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 242.0 113.0 100.0 2.0 0.896825396825397 H 116.0 10.0 1.0 1.0 COG2037 Formylmethanofuran:tetrahydromethanopterin_formyltransferase Ftr 126.0 0.9206349206349206 0.0793650793650793 0.0859172895407938 0.0955870657662422 0.090752177653518 0.0096697762254483 0 0 0 0 K00673 0.0 0.074074074074074 astA; arginine N-succinyltransferase [EC:2.3.1.109] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 282.0 28.0 26.0 2.0 0.933333333333333 E 0.0 31.0 2.0 0.967741935483871 COG3138 Arginine/ornithine_N-succinyltransferase_beta_subunit AstA 31.0 0.0 1.0 0.0107301250290441 0.0509611424199416 0.0308456337244928 0.0402310173908975 0 0 0 0 K00674 0.1142857142857142 0.4558404558404558 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117] path:map00300,path:map01100,path:map01120,path:map01230 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of amino acids 173.0 201.0 199.0 2.0 0.990147783251232 E 40.0 163.0 1.0 1.0 COG2171 Tetrahydrodipicolinate_N-succinyltransferase DapD 203.0 0.1970443349753694 0.8029556650246306 0.0022759477434506 0.0112802022947572 0.0067780750191039 0.0090042545513065 0 0 0 0 K00675 0.0257142857142857 0.0968660968660968 nhoA; N-hydroxyarylamine O-acetyltransferase [EC:2.3.1.118] 130.0 36.0 23.0 2.0 0.73469387755102 Q 10.0 39.0 1.0 1.0 COG2162 Arylamine_N-acetyltransferase NhoA 49.0 0.2040816326530612 0.7959183673469388 0.0045212117386172 0.015831995300469 0.010176603519543 0.0113107835618517 0 0 0 0 K00677 0.0085714285714285 0.5754985754985755 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] path:map00540,path:map01100,path:map01503 Lipopolysaccharide biosynthesis,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance 200.0 209.0 197.0 3.0 0.937219730941704 M 3.0 220.0 2.0 0.991031390134529 COG1043 Acyl-[acyl_carrier_protein]--UDP-N-acetylglucosamine_O-acyltransferase LpxA 223.0 0.0134529147982062 0.9865470852017936 0.716236080419777 0.296027449005192 0.5061317647124846 0.420208631414585 0 0 0 1 K00680 0.0 0.0113960113960113 ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-] 164.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 5.0 0.0 1.0 0.0190535976003975 0.0263128829888927 0.0226832402946451 0.0072592853884951 0 0 0 0 K00681 0.22 0.4615384615384615 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] path:map00430,path:map00460,path:map00480,path:map01100 Taurine and hypotaurine metabolism,Cyanoamino acid metabolism,Glutathione metabolism,Metabolic pathways 189.0 349.0 286.0 3.0 0.842995169082126 E 94.0 320.0 2.0 0.995169082125604 COG0405 Gamma-glutamyltranspeptidase Ggt 414.0 0.2270531400966183 0.7729468599033816 0.297196124921809 0.892884758854969 0.595040441888389 0.59568863393316 0 0 0 0 K00682 0.0028571428571428 0.0 GGCT; gamma-glutamylcyclotransferase [EC:4.3.2.9] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 156.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG4059 1.0 1.0 0.0 0 0 0 0 K00683 0.0257142857142857 0.0968660968660968 QPCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5] 181.0 30.0 14.0 2.0 0.652173913043478 O 10.0 36.0 1.0 1.0 COG3823 Glutamine_cyclotransferase 46.0 0.217391304347826 0.782608695652174 0.0107206002665255 0.0347909207020789 0.0227557604843022 0.0240703204355533 0 0 0 0 K00684 0.0028571428571428 0.3931623931623931 aat; leucyl/phenylalanyl-tRNA---protein transferase [EC:2.3.2.6] 158.0 136.0 131.0 2.0 0.964539007092198 O 1.0 140.0 1.0 1.0 COG2360 Leu/Phe-tRNA-protein_transferase Aat 141.0 0.0070921985815602 0.9929078014184396 0.009166034857236 0.0922239389623927 0.0506949869098143 0.0830579041051567 0 0 0 0 K00686 0.0 0.0113960113960113 tgl; protein-glutamine gamma-glutamyltransferase [EC:2.3.2.13] 249.0 3.0 2.0 2.0 0.75 I 0.0 4.0 1.0 1.0 arCOG13259 4.0 0.0 1.0 0.0165428077804561 0.0929800750425169 0.0547614414114865 0.0764372672620608 0 0 0 0 K00687 0.0 0.037037037037037 pbp2B, penA; penicillin-binding protein 2B path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 616.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 13.0 0.0 1.0 0.0048033418735615 0.0033653086240029 0.0040843252487822 0.0014380332495586 0 0 0 0 K00688 0.2 0.6210826210826211 PYG, glgP; glycogen phosphorylase [EC:2.4.1.1] path:map00500,path:map01100,path:map01110,path:map02026,path:map04217,path:map04910,path:map04922,path:map04931 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biofilm formation - Escherichia coli,Necroptosis,Insulin signaling pathway,Glucagon signaling pathway,Insulin resistance 292.0 356.0 334.0 4.0 0.887780548628429 G 79.0 322.0 2.0 0.972568578553616 COG0058 Glucan_phosphorylase GlgP 401.0 0.1970074812967581 0.8029925187032418 0.198876884700991 0.453382850924474 0.3261298678127325 0.254505966223483 0 0 0 0 K00689 0.0 0.0113960113960113 E2.4.1.5; dextransucrase [EC:2.4.1.5] path:map00500,path:map01100,path:map02020 Starch and sucrose metabolism,Metabolic pathways,Two-component system 523.0 2.0 0.0 3.0 0.4 G 0.0 5.0 3.0 0.4 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 5.0 0.0 1.0 0.0373940027611662 0.298335999473959 0.1678650011175626 0.2609419967127928 0 0 0 0 K00690 0.0114285714285714 0.1054131054131054 E2.4.1.7; sucrose phosphorylase [EC:2.4.1.7] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 371.0 44.0 0.0 1.0 1.0 G 4.0 40.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 44.0 0.0909090909090909 0.9090909090909092 0.130133531618234 0.497670279798064 0.313901905708149 0.36753674817983 0 0 0 0 K00691 0.02 0.0968660968660968 mapA; maltose phosphorylase [EC:2.4.1.8] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 301.0 49.0 0.0 1.0 1.0 G 7.0 42.0 3.0 0.530612244897959 COG0058 Glucan_phosphorylase GlgP 49.0 0.1428571428571428 0.8571428571428571 0.1611796191539 0.18041013182829 0.170794875491095 0.0192305126743899 0 0 0 0 K00692 0.0428571428571428 0.0313390313390313 sacB; levansucrase [EC:2.4.1.10] path:map00500,path:map01100,path:map02020 Starch and sucrose metabolism,Metabolic pathways,Two-component system 312.0 17.0 6.0 2.0 0.607142857142857 M 16.0 12.0 2.0 0.571428571428571 arCOG08133 28.0 0.5714285714285714 0.4285714285714285 0.0816458501277097 0.0229749350999053 0.0523103926138075 0.0586709150278043 0 0 0 0 K00693 0.0857142857142857 0.0313390313390313 GYS; glycogen synthase [EC:2.4.1.11] path:map00500,path:map01100,path:map01110,path:map04151,path:map04152,path:map04910,path:map04922,path:map04931,path:map05415 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,PI3K-Akt signaling pathway,AMPK signaling pathway,Insulin signaling pathway,Glucagon signaling pathway,Insulin resistance,Diabetic cardiomyopathy 418.0 15.0 2.0 4.0 0.365853658536585 G 30.0 11.0 2.0 0.804878048780488 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 41.0 0.7317073170731707 0.2682926829268293 0.569712874654199 0.650267730627772 0.6099903026409854 0.080554855973573 0 1 0 1 K00694 0.06 0.2051282051282051 bcsA; cellulose synthase (UDP-forming) [EC:2.4.1.12] path:map00500,path:map01100,path:map02026 Starch and sucrose metabolism,Metabolic pathways,Biofilm formation - Escherichia coli 115.0 91.0 87.0 8.0 0.858490566037736 M 23.0 82.0 5.0 0.886792452830189 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 105.0 0.219047619047619 0.780952380952381 0.141018975850983 0.785699271776222 0.4633591238136025 0.644680295925239 0 0 0 0 K00695 0.0 0.0341880341880341 SUS; sucrose synthase [EC:2.4.1.13] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 788.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 15.0 0.0 1.0 0.0132634252880804 0.0247345465648664 0.0189989859264734 0.011471121276786 0 0 0 0 K00696 0.0 0.0 E2.4.1.14; sucrose-phosphate synthase [EC:2.4.1.14] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 26.0 17.0 4.0 0.577777777777778 M 0.0 0.0 3.0 0.533333333333333 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 0.0 0 0 0 0 K00697 0.1457142857142857 0.2507122507122507 otsA; trehalose 6-phosphate synthase [EC:2.4.1.15 2.4.1.347] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 279.0 151.0 147.0 2.0 0.974193548387097 G 55.0 99.0 2.0 0.974193548387097 COG0380 Trehalose-6-phosphate_synthase,_GT20_family OtsA 154.0 0.3571428571428571 0.6428571428571429 0.0159343432920127 0.62498229307565 0.3204583181838313 0.6090479497836373 0 0 0 0 K00698 0.0057142857142857 0.0 CHS1; chitin synthase [EC:2.4.1.16] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 95.0 2.0 0.0 1.0 1.0 M 2.0 0.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 2.0 1.0 0.0 0 0 0 0 K00699 0.0 0.0028490028490028 UGT; glucuronosyltransferase [EC:2.4.1.17] path:map00040,path:map00053,path:map00140,path:map00830,path:map00860,path:map00980,path:map00982,path:map00983,path:map01100,path:map01110,path:map01240,path:map04976,path:map05204,path:map05207 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis,Retinol metabolism,Porphyrin metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Bile secretion,Chemical carcinogenesis - DNA adducts,Chemical carcinogenesis - receptor activation 436.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 KOG1192 1.0 0.0 1.0 0 0 0 0 K00700 0.0485714285714285 0.5327635327635327 GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 262.0 266.0 265.0 7.0 0.977941176470588 G 24.0 248.0 6.0 0.944852941176471 COG0296 1,4-alpha-glucan_branching_enzyme GlgB 272.0 0.088235294117647 0.9117647058823528 0.0298882481826723 0.119613442783008 0.0747508454828401 0.0897251946003357 0 0 0 0 K00701 0.0 0.0313390313390313 cgt; cyclomaltodextrin glucanotransferase [EC:2.4.1.19] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 439.0 11.0 10.0 2.0 0.916666666666667 G 0.0 12.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 12.0 0.0 1.0 0.0465944718438363 0.142280175278423 0.0944373235611296 0.0956857034345866 0 0 0 0 K00702 0.0114285714285714 0.0968660968660968 E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 520.0 51.0 49.0 2.0 0.962264150943396 G 6.0 47.0 2.0 0.943396226415094 COG3459 Cellobiose_phosphorylase 53.0 0.1132075471698113 0.8867924528301887 0.266504578773021 0.250882476098186 0.2586935274356035 0.0156221026748349 0 0 0 0 K00703 0.1085714285714285 0.584045584045584 glgA; starch synthase [EC:2.4.1.21] path:map00500,path:map01100,path:map01110,path:map02026 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biofilm formation - Escherichia coli 149.0 200.0 145.0 7.0 0.677966101694915 G 39.0 256.0 6.0 0.966101694915254 COG0297 Glycogen_synthase GlgA 295.0 0.1322033898305084 0.8677966101694915 0.114030105136386 0.446687655717057 0.2803588804267215 0.332657550580671 0 0 0 0 K00705 0.0942857142857142 0.4615384615384615 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 189.0 237.0 235.0 2.0 0.99163179916318 G 36.0 203.0 6.0 0.891213389121339 COG1640 4-alpha-glucanotransferase MalQ 239.0 0.1506276150627615 0.8493723849372385 0.0827477793195393 0.795368542831048 0.4390581610752936 0.7126207635115087 0 0 0 0 K00710 0.0 0.0028490028490028 GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41] path:map00512,path:map00514,path:map01100 Mucin type O-glycan biosynthesis,Other types of O-glycan biosynthesis,Metabolic pathways 547.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 KOG3736 1.0 0.0 1.0 0 0 0 0 K00712 0.0 0.0484330484330484 tagE; poly(glycerol-phosphate) alpha-glucosyltransferase [EC:2.4.1.52] path:map00552 Teichoic acid biosynthesis 117.0 19.0 18.0 2.0 0.95 M 0.0 23.0 3.0 0.826086956521739 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 23.0 0.0 1.0 0.0476852046555159 0.14415317387483 0.0959191892651729 0.0964679692193141 0 0 0 0 K00713 0.0 0.0227920227920227 waaD; UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase [EC:2.4.1.-] path:map00540 Lipopolysaccharide biosynthesis 302.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 8.0 0.0 1.0 0.0970536041862553 0.353691626386144 0.2253726152861996 0.2566380221998887 0 0 0 0 K00720 0.0057142857142857 0.0968660968660968 UGCG; ceramide glucosyltransferase [EC:2.4.1.80] path:map00600,path:map01100 Sphingolipid metabolism,Metabolic pathways 230.0 44.0 42.0 2.0 0.956521739130435 M 2.0 44.0 2.0 0.956521739130435 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 46.0 0.0434782608695652 0.9565217391304348 0.004724776903324 0.127966793283116 0.06634578509322 0.123242016379792 0 0 0 0 K00721 0.6314285714285715 0.5584045584045584 DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] path:map00510,path:map01100 N-Glycan biosynthesis,Metabolic pathways 11.0 582.0 487.0 6.0 0.829059829059829 M 318.0 359.0 8.0 0.678062678062678 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 677.0 0.4697193500738552 0.5302806499261448 0.144212816276357 0.290106036010255 0.2171594261433059 0.145893219733898 0 0 0 0 K00728 0.0342857142857142 0.1595441595441595 POMT, pmt; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109] path:map00514,path:map00515,path:map01100 Other types of O-glycan biosynthesis,Mannose type O-glycan biosynthesis,Metabolic pathways 196.0 63.0 51.0 4.0 0.777777777777778 O 16.0 65.0 5.0 0.432098765432099 COG4346 Predicted_membrane-bound_dolichyl-phosphate-mannose-protein_mannosyltransferase 81.0 0.1975308641975308 0.8024691358024691 0.100087514388596 0.997742690527306 0.548915102457951 0.89765517613871 0 0 0 0 K00729 0.0 0.0056980056980056 ALG5; dolichyl-phosphate beta-glucosyltransferase [EC:2.4.1.117] path:map00510,path:map01100 N-Glycan biosynthesis,Metabolic pathways 225.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 2.0 0.0 1.0 0 0 0 0 K00737 0.0 0.0142450142450142 MGAT3; beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.144] path:map00510,path:map01100 N-Glycan biosynthesis,Metabolic pathways 253.0 5.0 0.0 1.0 1.0 M 0.0 5.0 2.0 0.8 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 5.0 0.0 1.0 0.0636832090156464 0.210155876024514 0.1369195425200802 0.1464726670088675 0 0 0 0 K00743 0.0314285714285714 0.0113960113960113 GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase [EC:2.4.1.87] path:map00601,path:map01100 Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways 291.0 18.0 0.0 1.0 1.0 M 14.0 4.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 18.0 0.7777777777777778 0.2222222222222222 0.0671046150444965 0.19656723335227 0.1318359241983832 0.1294626183077735 0 0 0 0 K00745 0.0028571428571428 0.0028490028490028 203.0 2.0 0.0 1.0 1.0 M 1.0 1.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 2.0 0.5 0.5 0 0 0 0 K00748 0.0 0.584045584045584 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 136.0 219.0 205.0 3.0 0.935897435897436 M 0.0 234.0 2.0 0.987179487179487 COG0763 Lipid_A_disaccharide_synthetase LpxB 234.0 0.0 1.0 0.61521086313899 0.0693296449184491 0.3422702540287195 0.5458812182205409 0 0 0 1 K00750 0.0028571428571428 0.0028490028490028 GYG1, GYG2; glycogenin [EC:2.4.1.186] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 252.0 1.0 0.0 2.0 0.5 H 1.0 1.0 1.0 1.0 COG5597 N-acetylglucosaminyl_transferase Gnt1 2.0 0.5 0.5 0 0 0 0 K00752 0.0257142857142857 0.0512820512820512 hasA; hyaluronan synthase [EC:2.4.1.212] 287.0 33.0 0.0 1.0 1.0 M 14.0 19.0 2.0 0.96969696969697 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 33.0 0.4242424242424242 0.5757575757575758 0.0239660686908741 0.12575549036261 0.074860779526742 0.1017894216717359 0 0 0 0 K00754 0.0771428571428571 0.282051282051282 bshA; L-malate glycosyltransferase [EC:2.4.1.-] 85.0 142.0 135.0 4.0 0.928104575163399 M 29.0 124.0 3.0 0.934640522875817 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 153.0 0.1895424836601307 0.8104575163398693 0.106126881616743 0.200997843614495 0.153562362615619 0.094870961997752 0 0 0 0 K00756 0.0142857142857142 0.376068376068376 pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 345.0 153.0 0.0 1.0 1.0 F 5.0 148.0 2.0 0.941176470588235 COG0213 Thymidine_phosphorylase DeoA 153.0 0.0326797385620915 0.9673202614379084 0.0300306243545934 0.265252035875908 0.1476413301152507 0.2352214115213146 0 0 0 0 K00757 0.2914285714285714 0.168091168091168 udp, UPP; uridine phosphorylase [EC:2.4.2.3] path:map00240,path:map00983,path:map01100,path:map01232 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 171.0 245.0 0.0 1.0 1.0 F 182.0 63.0 1.0 1.0 COG2820 Uridine_phosphorylase Udp 245.0 0.7428571428571429 0.2571428571428571 0.174423084499361 0.452308807659797 0.313365946079579 0.2778857231604359 0 0 0 0 K00758 0.04 0.3076923076923077 deoA, TYMP; thymidine phosphorylase [EC:2.4.2.4] path:map00240,path:map00983,path:map01100,path:map01232,path:map05219 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism,Bladder cancer 315.0 123.0 116.0 3.0 0.931818181818182 F 14.0 118.0 2.0 0.984848484848485 COG0213 Thymidine_phosphorylase DeoA 132.0 0.106060606060606 0.8939393939393939 0.0846130756660274 0.0642483771158809 0.0744307263909541 0.0203646985501465 0 0 0 0 K00759 0.6028571428571429 0.6780626780626781 APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 34.0 561.0 550.0 5.0 0.968911917098446 F 312.0 266.0 2.0 0.970639032815199 COG0503 Adenine/guanine_phosphoribosyltransferase_or_related_PRPP-binding_protein Apt 578.0 0.5397923875432526 0.4602076124567474 0.021034846764439 0.0913585404267969 0.0561966935956179 0.0703236936623579 0 0 0 0 K00760 0.0171428571428571 0.6923076923076923 hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] path:map00230,path:map00983,path:map01100,path:map01110,path:map01232 Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 88.0 272.0 243.0 3.0 0.885993485342019 F 6.0 301.0 4.0 0.859934853420196 COG0634 Hypoxanthine-guanine_phosphoribosyltransferase HptA 307.0 0.019543973941368 0.980456026058632 0.05958113844121 0.537932119919579 0.2987566291803945 0.478350981478369 0 0 0 0 K00761 0.2485714285714285 0.6410256410256411 upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 141.0 317.0 302.0 2.0 0.954819277108434 F 92.0 240.0 2.0 0.954819277108434 COG0035 Uracil_phosphoribosyltransferase Upp 332.0 0.2771084337349397 0.7228915662650602 0.013161332837581 0.0618161760372733 0.0374887544374271 0.0486548431996923 0 0 0 0 K00762 0.6971428571428572 0.8575498575498576 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 56.0 700.0 699.0 2.0 0.998573466476462 F 377.0 324.0 5.0 0.810271041369472 COG0461 Orotate_phosphoribosyltransferase PyrE 701.0 0.5378031383737518 0.4621968616262482 0.0131032487678596 0.0236514992203493 0.0183773739941044 0.0105482504524897 0 0 0 0 K00763 0.5171428571428571 0.6125356125356125 pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 179.0 389.0 354.0 2.0 0.917452830188679 H 196.0 228.0 1.0 1.0 COG1488 Nicotinic_acid_phosphoribosyltransferase PncB 424.0 0.4622641509433962 0.5377358490566038 0.784601210566518 0.127604086794608 0.456102648680563 0.65699712377191 1 1 1 1 K00764 0.6857142857142857 0.8518518518518519 purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14] path:map00230,path:map00250,path:map01100,path:map01110 Purine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 207.0 608.0 580.0 3.0 0.952978056426332 F 287.0 351.0 3.0 0.938871473354232 COG0034 Glutamine_phosphoribosylpyrophosphate_amidotransferase PurF 638.0 0.4498432601880878 0.5501567398119123 0.0601689239263665 0.0350747549506846 0.0476218394385255 0.0250941689756818 0 0 0 0 K00765 0.4914285714285714 0.7521367521367521 hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 94.0 311.0 167.0 3.0 0.67755991285403 E 184.0 275.0 3.0 0.982570806100218 COG0040 ATP_phosphoribosyltransferase HisG 459.0 0.4008714596949891 0.599128540305011 0.548943011045678 0.486757848009653 0.5178504295276655 0.062185163036025 0 1 0 1 K00766 0.4857142857142857 0.7435897435897436 trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 173.0 374.0 232.0 3.0 0.720616570327553 E 216.0 298.0 4.0 0.957610789980732 COG0547 Anthranilate_phosphoribosyltransferase,_glycosyltransferase_domain TrpD 514.0 0.4202334630350194 0.5797665369649806 0.303830578416899 0.603717208137517 0.4537738932772079 0.2998866297206179 0 0 0 0 K00767 0.5171428571428571 0.7037037037037037 nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 152.0 456.0 454.0 2.0 0.995633187772926 H 192.0 265.0 3.0 0.958515283842795 COG0157 Nicotinate-nucleotide_pyrophosphorylase NadC 457.0 0.4201312910284464 0.5798687089715536 0.64992634677418 0.800205370381893 0.7250658585780365 0.1502790236077129 0 1 0 1 K00768 0.04 0.4301994301994302 E2.4.2.21, cobU, cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 248.0 128.0 82.0 6.0 0.707182320441989 H 14.0 167.0 3.0 0.933701657458564 COG2038 NaMN:DMB_phosphoribosyltransferase CobT 181.0 0.0773480662983425 0.9226519337016574 0.159655834491441 0.635101343397609 0.397378588944525 0.475445508906168 0 0 0 0 K00769 0.16 0.1225071225071225 gpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] path:map00230,path:map01100,path:map01110,path:map01232 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 104.0 103.0 0.0 1.0 1.0 F 58.0 45.0 1.0 1.0 COG2236 Hypoxanthine_phosphoribosyltransferase Hpt1 103.0 0.5631067961165048 0.4368932038834951 0.923929541087603 0.970807715242782 0.9473686281651924 0.046878174155179 1 1 1 1 K00771 0.0028571428571428 0.0056980056980056 XYLT; protein xylosyltransferase [EC:2.4.2.26] path:map00532,path:map00534,path:map01100 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways 192.0 3.0 0.0 1.0 1.0 M 1.0 2.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K00772 0.6657142857142857 0.4558404558404558 mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 156.0 484.0 0.0 1.0 1.0 F 296.0 188.0 3.0 0.886363636363636 COG0005 Purine_nucleoside_phosphorylase XapA 484.0 0.6115702479338843 0.3884297520661157 0.267022797512379 0.353750698298918 0.3103867479056484 0.0867279007865389 0 0 0 0 K00773 0.0914285714285714 0.9031339031339032 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29] 255.0 196.0 16.0 3.0 0.517150395778364 J 32.0 347.0 3.0 0.984168865435356 COG0343 Queuine/archaeosine_tRNA-ribosyltransferase Tgt 379.0 0.0844327176781002 0.9155672823218998 0.792062503598111 0.229656807801773 0.5108596556999421 0.562405695796338 1 1 1 1 K00782 0.2771428571428571 0.301994301994302 lldG; L-lactate dehydrogenase complex protein LldG 61.0 164.0 81.0 2.0 0.663967611336032 S 121.0 124.0 3.0 0.676113360323887 COG1556 L-lactate_utilization_protein_LutC,_contains_LUD_domain LutC 245.0 0.4938775510204081 0.5061224489795918 0.0090199318798168 0.228766659349719 0.1188932956147679 0.2197467274699021 0 0 0 0 K00783 0.0685714285714285 0.5555555555555556 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] 85.0 220.0 218.0 2.0 0.990990990990991 J 26.0 196.0 1.0 1.0 COG1576 23S_rRNA_pseudoU1915_N3-methylase_RlmH RlmH 222.0 0.1171171171171171 0.8828828828828829 0.906741764320575 0.356415645163403 0.631578704741989 0.550326119157172 1 1 1 1 K00784 0.9285714285714286 0.4301994301994302 rnz; ribonuclease Z [EC:3.1.26.11] 73.0 348.0 103.0 5.0 0.548895899053628 J 431.0 203.0 4.0 0.946372239747634 COG1234 Ribonuclease_BN,_tRNA_processing_enzyme ElaC 634.0 0.6798107255520505 0.3201892744479495 0.378534077020892 0.381495702559008 0.38001488978995 0.002961625538116 0 0 0 0 K00785 0.0 0.0056980056980056 lst; N-acetyllactosaminide alpha-2,3-sialyltransferase [EC:2.4.3.6] 301.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 28MFQ 2.0 0.0 1.0 0 0 0 0 K00786 0.1828571428571428 0.2364672364672364 GALT29A; beta-1,6-galactosyltransferase [EC:2.4.1.-] 7.0 180.0 154.0 4.0 0.845070422535211 M 92.0 111.0 9.0 0.427230046948357 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 203.0 0.4532019704433497 0.5467980295566502 0.0363470304757655 0.0810237240773984 0.0586853772765819 0.0446766936016329 0 0 0 0 K00788 0.2685714285714285 0.7037037037037037 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 15.0 473.0 461.0 3.0 0.959432048681541 H 110.0 383.0 5.0 0.945233265720081 COG0352 Thiamine_monophosphate_synthase ThiE 493.0 0.2231237322515213 0.7768762677484787 0.0273122248374507 0.036061978963079 0.0316871019002648 0.0087497541256283 0 0 0 0 K00789 0.7742857142857142 0.945868945868946 metK, MAT; S-adenosylmethionine synthetase [EC:2.5.1.6] path:map00270,path:map00999,path:map01100,path:map01110,path:map01230,path:map01240 Cysteine and methionine metabolism,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Biosynthesis of cofactors 179.0 585.0 496.0 4.0 0.852769679300292 H 291.0 395.0 3.0 0.658892128279883 COG0192 S-adenosylmethionine_synthetase MetK 686.0 0.4241982507288629 0.575801749271137 0.0045083661186434 0.0462617340777634 0.0253850500982034 0.04175336795912 0 0 0 0 K00790 0.0171428571428571 0.9572649572649572 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] path:map00520,path:map00550,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Peptidoglycan biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 268.0 392.0 386.0 4.0 0.96551724137931 M 6.0 400.0 4.0 0.970443349753695 COG0766 UDP-N-acetylglucosamine_enolpyruvyl_transferase MurA 406.0 0.0147783251231527 0.9852216748768472 0.66678509837843 0.220951916017448 0.443868507197939 0.445833182360982 0 1 0 1 K00791 0.0 0.9715099715099716 miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75] path:map00908,path:map01100,path:map01110 Zeatin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 108.0 301.0 267.0 3.0 0.836111111111111 J 0.0 360.0 1.0 1.0 COG0324 tRNA_A37_N6-isopentenylltransferase_MiaA MiaA 360.0 0.0 1.0 0.828559866945145 0.257230095784094 0.5428949813646196 0.571329771161051 0 0 1 1 K00793 0.5457142857142857 0.7977207977207977 ribE, RIB5; riboflavin synthase [EC:2.5.1.9] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 76.0 479.0 0.0 1.0 1.0 H 195.0 284.0 3.0 0.757828810020877 COG0307 Riboflavin_synthase_alpha_chain RibC 479.0 0.407098121085595 0.592901878914405 0.0262009919005123 0.511485564983338 0.2688432784419251 0.4852845730828257 0 0 0 0 K00794 0.5371428571428571 0.7948717948717948 ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 105.0 480.0 0.0 1.0 1.0 H 189.0 291.0 1.0 1.0 COG0054 6,7-dimethyl-8-ribityllumazine_synthase_(Riboflavin_synthase_beta_chain) RibE 480.0 0.39375 0.60625 0.026098594039835 0.106712169958582 0.0664053819992085 0.080613575918747 0 0 0 0 K00795 0.0 0.2849002849002849 ispA; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 213.0 103.0 0.0 1.0 1.0 H 0.0 103.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 103.0 0.0 1.0 0.0032454305758929 0.039698380274586 0.0214719054252394 0.0364529496986931 0 0 0 0 K00796 0.4485714285714285 0.8176638176638177 folP; dihydropteroate synthase [EC:2.5.1.15] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 111.0 532.0 525.0 2.0 0.987012987012987 H 211.0 328.0 4.0 0.968460111317254 COG0294 Dihydropteroate_synthase FolP 539.0 0.3914656771799629 0.608534322820037 0.271124655432221 0.325342238871411 0.298233447151816 0.05421758343919 0 0 0 0 K00797 0.3257142857142857 0.5811965811965812 speE, SRM, SPE3; spermidine synthase [EC:2.5.1.16] path:map00270,path:map00330,path:map00480,path:map01100 Cysteine and methionine metabolism,Arginine and proline metabolism,Glutathione metabolism,Metabolic pathways 32.0 270.0 172.0 6.0 0.627906976744186 E 127.0 298.0 6.0 0.741860465116279 COG0421 Spermidine_synthase_(polyamine_aminopropyltransferase) SpeE 425.0 0.2988235294117647 0.7011764705882353 0.586338483851171 0.482494967474661 0.534416725662916 0.10384351637651 0 1 0 1 K00798 0.3828571428571428 0.5612535612535613 MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 80.0 253.0 147.0 2.0 0.704735376044568 S 152.0 207.0 2.0 0.969359331476323 COG2096 Cob(II)alamin_adenosyltransferase PduO 359.0 0.4233983286908078 0.5766016713091922 0.0022224085325715 0.292985475992639 0.1476039422626052 0.2907630674600675 0 0 0 0 K00799 0.02 0.2592592592592592 GST, gst; glutathione S-transferase [EC:2.5.1.18] path:map00480,path:map00980,path:map00982,path:map00983,path:map01100,path:map01524,path:map04212,path:map05200,path:map05204,path:map05207,path:map05208,path:map05225,path:map05418 Glutathione metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Drug metabolism - other enzymes,Metabolic pathways,Platinum drug resistance,Longevity regulating pathway - worm,Pathways in cancer,Chemical carcinogenesis - DNA adducts,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species,Hepatocellular carcinoma,Fluid shear stress and atherosclerosis 24.0 437.0 413.0 4.0 0.910416666666667 O 8.0 467.0 9.0 0.939583333333333 COG0625 Glutathione_S-transferase GstA 475.0 0.0168421052631578 0.983157894736842 0.0033051431082832 0.018402021512054 0.0108535823101686 0.0150968784037708 0 0 0 0 K00800 0.5628571428571428 0.8347578347578347 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 123.0 506.0 479.0 5.0 0.937037037037037 E 205.0 334.0 8.0 0.951851851851852 COG0128 5-enolpyruvylshikimate-3-phosphate_synthase AroA 539.0 0.3803339517625232 0.6196660482374768 0.0347012998573532 0.651711500672789 0.3432064002650711 0.6170102008154359 0 0 0 0 K00801 0.16 0.1168091168091168 FDFT1; farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21] path:map00100,path:map00909,path:map01100,path:map01110 Steroid biosynthesis,Sesquiterpenoid and triterpenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 166.0 99.0 0.0 1.0 1.0 I 56.0 43.0 2.0 0.98989898989899 COG1562 Phytoene/squalene_synthetase ERG9 99.0 0.5656565656565656 0.4343434343434343 0.0014379271158814 0.0068993009619208 0.004168614038901 0.0054613738460393 0 0 0 0 K00803 0.1028571428571428 0.1253561253561253 AGPS, agpS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26] path:map00565,path:map01100,path:map04146 Ether lipid metabolism,Metabolic pathways,Peroxisome 258.0 104.0 0.0 1.0 1.0 C 53.0 51.0 2.0 0.884615384615385 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 104.0 0.5096153846153846 0.4903846153846153 0.958608892878584 0.992771392135084 0.975690142506834 0.0341624992565 1 1 1 1 K00805 0.0171428571428571 0.339031339031339 hepS; heptaprenyl diphosphate synthase component 1 [EC:2.5.1.30] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 64.0 106.0 41.0 2.0 0.619883040935672 H 6.0 165.0 4.0 0.619883040935673 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 171.0 0.0350877192982456 0.9649122807017544 0.0227983291792656 0.539859248754961 0.2813287889671133 0.5170609195756954 0 0 0 0 K00806 0.4685714285714286 0.9344729344729344 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] path:map00550,path:map00900,path:map01110 Peptidoglycan biosynthesis,Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 94.0 285.0 12.0 3.0 0.509838998211091 H 177.0 382.0 1.0 1.0 COG0020 Undecaprenyl_pyrophosphate_synthase UppS 559.0 0.3166368515205724 0.6833631484794276 0.0092786818204983 0.51413196928664 0.2617053255535691 0.5048532874661417 0 0 0 0 K00808 0.0142857142857142 0.0427350427350427 hss; homospermidine synthase [EC:2.5.1.44] path:map00960,path:map01110 Tropane, piperidine and pyridine alkaloid biosynthesis,Biosynthesis of secondary metabolites 444.0 22.0 0.0 1.0 1.0 Q 5.0 17.0 1.0 1.0 COG5310 Homospermidine_synthase 22.0 0.2272727272727272 0.7727272727272727 0.0017318969400727 0.0058596981779024 0.0037957975589875 0.0041278012378297 0 0 0 0 K00809 0.9342857142857144 0.2165242165242165 DHPS, dys; deoxyhypusine synthase [EC:2.5.1.46] 176.0 323.0 159.0 3.0 0.633333333333333 O 431.0 79.0 1.0 1.0 COG1899 Deoxyhypusine_synthase DYS1 510.0 0.8450980392156863 0.1549019607843137 0.0107181343399237 0.787851657514792 0.3992848959273579 0.7771335231748683 0 0 0 0 K00812 0.72 0.6894586894586895 aspB; aspartate aminotransferase [EC:2.6.1.1] path:map00220,path:map00250,path:map00270,path:map00330,path:map00350,path:map00360,path:map00400,path:map00401,path:map00950,path:map00960,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism,Arginine and proline metabolism,Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Isoquinoline alkaloid biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 129.0 863.0 850.0 2.0 0.985159817351598 E 468.0 408.0 2.0 0.998858447488584 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 876.0 0.5342465753424658 0.4657534246575342 0.0346207015670834 0.299007344806482 0.1668140231867827 0.2643866432393986 0 0 0 0 K00813 0.0 0.1082621082621082 aspC; aspartate aminotransferase [EC:2.6.1.1] path:map00220,path:map00250,path:map00270,path:map00330,path:map00350,path:map00360,path:map00400,path:map00401,path:map00950,path:map00960,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism,Arginine and proline metabolism,Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Isoquinoline alkaloid biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 360.0 38.0 0.0 1.0 1.0 E 0.0 38.0 1.0 1.0 COG1448 Aspartate/aromatic_aminotransferase TyrB 38.0 0.0 1.0 0.0107426658794981 0.104791574376753 0.0577671201281255 0.0940489084972549 0 0 0 0 K00814 0.0057142857142857 0.037037037037037 GPT, ALT; alanine transaminase [EC:2.6.1.2] path:map00220,path:map00250,path:map00710,path:map01100,path:map01120,path:map01200,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 397.0 15.0 0.0 1.0 1.0 E 2.0 13.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 15.0 0.1333333333333333 0.8666666666666667 0.0660666703382677 0.550263555454907 0.3081651128965874 0.4841968851166393 0 0 0 0 K00817 0.58 0.8062678062678063 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] path:map00340,path:map00350,path:map00360,path:map00400,path:map00401,path:map00960,path:map01100,path:map01110,path:map01230 Histidine metabolism,Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 70.0 780.0 772.0 3.0 0.983606557377049 E 298.0 495.0 6.0 0.948297604035309 COG0079 Histidinol-phosphate/aromatic_aminotransferase_or_cobyric_acid_decarboxylase HisC 793.0 0.3757881462799495 0.6242118537200504 0.0031567459428951 0.382832286269164 0.1929945161060295 0.3796755403262689 0 0 0 0 K00819 0.0342857142857142 0.2364672364672364 rocD, OAT; ornithine--oxo-acid transaminase [EC:2.6.1.13] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 347.0 96.0 93.0 2.0 0.96969696969697 E 12.0 87.0 2.0 0.95959595959596 COG4992 Acetylornithine/succinyldiaminopimelate/putrescine_aminotransferase ArgD 99.0 0.1212121212121212 0.8787878787878788 0.0420875123341502 0.366079483386455 0.2040834978603026 0.3239919710523048 0 0 0 0 K00820 0.7857142857142857 0.9002849002849003 glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] path:map00250,path:map00520,path:map01100,path:map01250,path:map04931,path:map05415 Alanine, aspartate and glutamate metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars,Insulin resistance,Diabetic cardiomyopathy 150.0 827.0 820.0 5.0 0.977541371158392 M 426.0 419.0 8.0 0.932624113475177 COG0449 Glucosamine_6-phosphate_synthetase,_contains_amidotransferase_and_phosphosugar_isomerase_domains GlmS 845.0 0.5041420118343195 0.4958579881656805 0.397892779371372 0.146459372984502 0.272176076177937 0.25143340638687 0 0 0 0 K00821 0.24 0.7492877492877493 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] path:map00220,path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Arginine biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 197.0 408.0 385.0 2.0 0.946635730858469 E 87.0 344.0 4.0 0.94431554524362 COG4992 Acetylornithine/succinyldiaminopimelate/putrescine_aminotransferase ArgD 431.0 0.2018561484918793 0.7981438515081206 0.464066835851034 0.985474466338666 0.72477065109485 0.5214076304876321 0 0 0 0 K00822 0.0 0.1025641025641025 E2.6.1.18; beta-alanine--pyruvate transaminase [EC:2.6.1.18] path:map00280,path:map00410,path:map00640,path:map01100 Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Propanoate metabolism,Metabolic pathways 409.0 25.0 6.0 2.0 0.568181818181818 E 0.0 44.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 44.0 0.0 1.0 0.0150918859998884 0.0517167511351295 0.0334043185675089 0.0366248651352411 0 0 0 0 K00823 0.4028571428571428 0.2421652421652421 puuE; 4-aminobutyrate aminotransferase [EC:2.6.1.19] path:map00250,path:map00410,path:map00640,path:map00650,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 220.0 281.0 237.0 3.0 0.841317365269461 E 231.0 103.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 334.0 0.6916167664670658 0.3083832335329341 0.933992564273012 0.992563477619504 0.963278020946258 0.058570913346492 1 1 1 1 K00824 0.0028571428571428 0.2193732193732193 dat; D-alanine transaminase [EC:2.6.1.21] path:map00310,path:map00330,path:map00360,path:map00470,path:map01100 Lysine degradation,Arginine and proline metabolism,Phenylalanine metabolism,D-Amino acid metabolism,Metabolic pathways 203.0 55.0 37.0 3.0 0.670731707317073 EH 1.0 81.0 1.0 1.0 COG0115 Branched-chain_amino_acid_aminotransferase/4-amino-4-deoxychorismate_lyase IlvE 82.0 0.0121951219512195 0.9878048780487804 0.0275162957085941 0.646816687553963 0.3371664916312786 0.6193003918453689 0 0 0 0 K00826 0.5485714285714286 0.8148148148148148 E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] path:map00270,path:map00280,path:map00290,path:map00770,path:map00966,path:map01100,path:map01110,path:map01210,path:map01230,path:map01240 Cysteine and methionine metabolism,Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis,Pantothenate and CoA biosynthesis,Glucosinolate biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 75.0 563.0 411.0 3.0 0.760810810810811 E 264.0 476.0 1.0 1.0 COG0115 Branched-chain_amino_acid_aminotransferase/4-amino-4-deoxychorismate_lyase IlvE 740.0 0.3567567567567568 0.6432432432432432 0.0968765337352227 0.396660813536837 0.2467686736360298 0.2997842798016143 0 0 0 0 K00830 0.1571428571428571 0.2279202279202279 AGXT; alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC:2.6.1.44 2.6.1.45 2.6.1.51] path:map00250,path:map00260,path:map00630,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map04146 Alanine, aspartate and glutamate metabolism,Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Peroxisome 276.0 149.0 142.0 2.0 0.955128205128205 E 60.0 96.0 1.0 1.0 COG0075 Archaeal_aspartate_aminotransferase_or_a_related_aminotransferase,_includes_purine_catabolism_protein_PucG PucG 156.0 0.3846153846153846 0.6153846153846154 0.623119317576201 0.382625137303953 0.502872227440077 0.240494180272248 0 1 0 1 K00831 0.0428571428571428 0.5299145299145299 serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52] path:map00260,path:map00270,path:map00680,path:map00750,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map01240 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Methane metabolism,Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 260.0 146.0 95.0 4.0 0.691943127962085 E 16.0 195.0 2.0 0.976303317535545 COG1932 Phosphoserine_aminotransferase SerC 211.0 0.0758293838862559 0.924170616113744 0.0008773304857144 0.0098313225010302 0.0053543264933723 0.0089539920153158 0 0 0 0 K00832 0.0142857142857142 0.1339031339031339 tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57] path:map00270,path:map00350,path:map00360,path:map00400,path:map00401,path:map00950,path:map00960,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Isoquinoline alkaloid biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 344.0 64.0 0.0 1.0 1.0 E 6.0 58.0 2.0 0.984375 COG1448 Aspartate/aromatic_aminotransferase TyrB 64.0 0.09375 0.90625 0.0026585324023953 0.0097309074428878 0.0061947199226415 0.0070723750404925 0 0 0 0 K00833 0.0457142857142857 0.4216524216524216 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 292.0 157.0 133.0 2.0 0.867403314917127 H 16.0 165.0 2.0 0.988950276243094 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 181.0 0.0883977900552486 0.9116022099447514 0.0059123927211693 0.145790193336777 0.0758512930289731 0.1398778006156077 0 0 0 0 K00835 0.0 0.0598290598290598 avtA; valine--pyruvate aminotransferase [EC:2.6.1.66] path:map00290,path:map01100,path:map01110 Valine, leucine and isoleucine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 400.0 17.0 14.0 3.0 0.80952380952381 E 0.0 21.0 2.0 0.952380952380952 COG3977 Alanine-alpha-ketoisovalerate_(or_valine-pyruvate)_aminotransferase AvtA 21.0 0.0 1.0 0.0171056784241481 0.218692781744395 0.1178992300842715 0.2015871033202469 0 0 0 0 K00836 0.1771428571428571 0.1538461538461538 ectB, dat; diaminobutyrate-2-oxoglutarate transaminase [EC:2.6.1.76] path:map00260,path:map01100,path:map01120,path:map01210,path:map01230 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 325.0 117.0 102.0 4.0 0.823943661971831 E 78.0 64.0 3.0 0.929577464788732 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 142.0 0.5492957746478874 0.4507042253521127 0.775644542136684 0.257338070985269 0.5164913065609765 0.5183064711514149 1 1 1 1 K00839 0.0028571428571428 0.0484330484330484 pucG; (S)-ureidoglycine---glyoxylate transaminase [EC:2.6.1.112] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 347.0 19.0 0.0 1.0 1.0 E 1.0 18.0 1.0 1.0 COG0075 Archaeal_aspartate_aminotransferase_or_a_related_aminotransferase,_includes_purine_catabolism_protein_PucG PucG 19.0 0.0526315789473684 0.9473684210526316 0.0965281651569063 0.303425753127206 0.1999769591420561 0.2068975879702996 0 0 0 0 K00840 0.0 0.0227920227920227 astC; succinylornithine aminotransferase [EC:2.6.1.81] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 400.0 10.0 0.0 1.0 1.0 E 0.0 10.0 1.0 1.0 COG4992 Acetylornithine/succinyldiaminopimelate/putrescine_aminotransferase ArgD 10.0 0.0 1.0 0.0046057063126568 0.013059183523699 0.0088324449181779 0.0084534772110421 0 0 0 0 K00841 0.0057142857142857 0.0541310541310541 patA; aminotransferase [EC:2.6.1.-] path:map00300,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 340.0 30.0 0.0 1.0 1.0 E 2.0 28.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 30.0 0.0666666666666666 0.9333333333333332 0.0071592255314175 0.170492156746865 0.0888256911391412 0.1633329312154474 0 0 0 0 K00842 0.0028571428571428 0.0427350427350427 289.0 16.0 15.0 2.0 0.941176470588235 E 1.0 16.0 1.0 1.0 COG1168 Bifunctional_PLP-dependent_enzyme_with_beta-cystathionase_and_maltose_regulon_repressor_activities MalY 17.0 0.0588235294117647 0.9411764705882352 0.0892346432780182 0.280863613432747 0.1850491283553826 0.1916289701547288 0 0 0 0 K00844 0.0 0.0142450142450142 HK; hexokinase [EC:2.7.1.1] path:map00010,path:map00051,path:map00052,path:map00500,path:map00520,path:map00521,path:map00524,path:map01100,path:map01110,path:map01120,path:map01200,path:map01250,path:map04066,path:map04910,path:map04930,path:map04973,path:map05131,path:map05230 Glycolysis / Gluconeogenesis,Fructose and mannose metabolism,Galactose metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Streptomycin biosynthesis,Neomycin, kanamycin and gentamicin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of nucleotide sugars,HIF-1 signaling pathway,Insulin signaling pathway,Type II diabetes mellitus,Carbohydrate digestion and absorption,Shigellosis,Central carbon metabolism in cancer 402.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG5026 Hexokinase 6.0 0.0 1.0 0.0264921850700555 1.13341052476207e-08 0.0132460982020803 0.0264921737359502 0 0 0 0 K00845 0.38 0.7834757834757835 glk; glucokinase [EC:2.7.1.2] path:map00010,path:map00052,path:map00500,path:map00520,path:map00521,path:map00524,path:map01100,path:map01110,path:map01120,path:map01200,path:map01250 Glycolysis / Gluconeogenesis,Galactose metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Streptomycin biosynthesis,Neomycin, kanamycin and gentamicin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of nucleotide sugars 11.0 422.0 250.0 6.0 0.603719599427754 GK 145.0 541.0 8.0 0.846924177396281 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 686.0 0.2113702623906705 0.7886297376093294 0.0300305006133164 0.136446860064563 0.0832386803389396 0.1064163594512466 0 0 0 0 K00846 0.0085714285714285 0.0199430199430199 KHK; ketohexokinase [EC:2.7.1.3] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 119.0 8.0 6.0 3.0 0.727272727272727 G 3.0 8.0 2.0 0.818181818181818 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 11.0 0.2727272727272727 0.7272727272727273 0.330319925196921 0.482286469758123 0.4063031974775219 0.151966544561202 0 0 0 0 K00847 0.2114285714285714 0.5754985754985755 E2.7.1.4, scrK; fructokinase [EC:2.7.1.4] path:map00051,path:map00500,path:map00520,path:map01100,path:map01110,path:map01250 Fructose and mannose metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 32.0 309.0 253.0 7.0 0.782278481012658 G 88.0 307.0 5.0 0.820253164556962 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 395.0 0.2227848101265822 0.7772151898734178 0.0005854255589826 0.0051584205535053 0.0028719230562439 0.0045729949945227 0 0 0 0 K00848 0.0314285714285714 0.1766381766381766 rhaB; rhamnulokinase [EC:2.7.1.5] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 219.0 103.0 101.0 3.0 0.971698113207547 G 11.0 95.0 2.0 0.905660377358491 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 106.0 0.1037735849056603 0.8962264150943396 0.781307454691268 0.950432896644613 0.8658701756679406 0.1691254419533449 1 1 1 1 K00849 0.1457142857142857 0.3874643874643874 galK; galactokinase [EC:2.7.1.6] path:map00052,path:map00520,path:map01100,path:map01250 Galactose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 161.0 181.0 153.0 4.0 0.819004524886878 G 67.0 154.0 1.0 1.0 COG0153 Galactokinase GalK 221.0 0.3031674208144796 0.6968325791855203 0.643976366646801 0.955875898128621 0.7999261323877109 0.3118995314818199 0 1 0 1 K00850 0.06 0.5156695156695157 pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11] path:map00010,path:map00030,path:map00051,path:map00052,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map03018,path:map04066,path:map04152,path:map04919,path:map04922,path:map05230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Galactose metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,RNA degradation,HIF-1 signaling pathway,AMPK signaling pathway,Thyroid hormone signaling pathway,Glucagon signaling pathway,Central carbon metabolism in cancer 186.0 153.0 74.0 4.0 0.586206896551724 G 28.0 233.0 2.0 0.988505747126437 COG0205 6-phosphofructokinase PfkA 261.0 0.10727969348659 0.89272030651341 0.766368820808849 0.902735018840922 0.8345519198248855 0.1363661980320729 1 1 1 1 K00851 0.0314285714285714 0.3190883190883191 idnK, gntK; gluconokinase [EC:2.7.1.12] path:map00030,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 43.0 143.0 116.0 3.0 0.785714285714286 G 13.0 165.0 7.0 0.428571428571429 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 178.0 0.0730337078651685 0.9269662921348316 0.400572686479 0.306610197198733 0.3535914418388665 0.093962489280267 0 0 0 0 K00852 0.6028571428571429 0.5441595441595442 rbsK, RBKS; ribokinase [EC:2.7.1.15] path:map00030,path:map01100 Pentose phosphate pathway,Metabolic pathways 32.0 467.0 324.0 5.0 0.748397435897436 G 326.0 298.0 4.0 0.983974358974359 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 624.0 0.5224358974358975 0.4775641025641026 0.415495890462604 0.693463958433005 0.5544799244478045 0.277968067970401 0 0 0 0 K00853 0.0 0.150997150997151 araB; L-ribulokinase [EC:2.7.1.16] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 455.0 38.0 20.0 3.0 0.622950819672131 G 0.0 61.0 2.0 0.950819672131148 COG1069 Ribulose_kinase AraB 61.0 0.0 1.0 0.136786351567253 0.0242011313314461 0.0804937414493495 0.1125852202358068 0 0 0 0 K00854 0.1428571428571428 0.4444444444444444 xylB, XYLB; xylulokinase [EC:2.7.1.17] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 152.0 359.0 342.0 3.0 0.930051813471503 G 99.0 287.0 2.0 0.987046632124352 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 386.0 0.2564766839378238 0.7435233160621761 0.693266572125978 0.985531590993256 0.8393990815596171 0.292265018867278 0 1 0 1 K00855 0.0514285714285714 0.1623931623931624 PRK, prkB; phosphoribulokinase [EC:2.7.1.19] path:map00710,path:map01100,path:map01120,path:map01200 Carbon fixation in photosynthetic organisms,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 139.0 48.0 14.0 4.0 0.505263157894737 F 18.0 76.0 2.0 0.747368421052632 COG0572 Uridine_kinase Udk 94.0 0.1914893617021276 0.8085106382978723 0.105697925282639 0.191618060826649 0.148657993054644 0.08592013554401 0 0 0 0 K00856 0.0371428571428571 0.2336182336182336 ADK, adoK; adenosine kinase [EC:2.7.1.20] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 122.0 91.0 83.0 3.0 0.91 G 14.0 86.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 100.0 0.14 0.86 0.0103129640313613 0.562147382384022 0.2862301732076916 0.5518344183526607 0 0 0 0 K00857 0.1342857142857142 0.4131054131054131 tdk, TK; thymidine kinase [EC:2.7.1.21] path:map00240,path:map00983,path:map01100,path:map01232 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 125.0 192.0 186.0 2.0 0.96969696969697 F 48.0 150.0 2.0 0.95959595959596 COG1435 Thymidine_kinase Tdk 198.0 0.2424242424242424 0.7575757575757576 0.0762145807872932 0.766200177858659 0.4212073793229761 0.6899855970713658 0 0 0 0 K00858 0.7628571428571429 0.8831908831908832 ppnK, NADK; NAD+ kinase [EC:2.7.1.23] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 33.0 276.0 1.0 6.0 0.354755784061697 H 434.0 340.0 6.0 0.883033419023136 COG0061 NAD_kinase NadK 774.0 0.5607235142118863 0.4392764857881137 0.0016989724418415 0.0087906079157728 0.0052447901788071 0.0070916354739313 0 0 0 0 K00859 0.0885714285714285 0.8917378917378918 coaE; dephospho-CoA kinase [EC:2.7.1.24] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 54.0 256.0 158.0 6.0 0.679045092838196 H 32.0 345.0 5.0 0.93368700265252 COG0237 Dephospho-CoA_kinase CoaE 377.0 0.0848806366047745 0.9151193633952256 0.0020764454729573 0.103710193053356 0.0528933192631566 0.1016337475803987 0 0 0 0 K00860 0.24 0.3276353276353276 cysC; adenylylsulfate kinase [EC:2.7.1.25] path:map00230,path:map00920,path:map01100,path:map01120 Purine metabolism,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 103.0 117.0 8.0 3.0 0.5 P 93.0 141.0 4.0 0.935897435897436 COG0529 Adenylylsulfate_kinase_or_related_kinase CysC 234.0 0.3974358974358974 0.6025641025641025 0.327634574552844 0.905545965647736 0.61659027010029 0.5779113910948921 0 0 0 0 K00862 0.0028571428571428 0.0512820512820512 eryA; erythritol kinase (D-erythritol 1-phosphate-forming) [EC:2.7.1.215] 344.0 33.0 32.0 2.0 0.970588235294117 G 1.0 33.0 1.0 1.0 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 34.0 0.0294117647058823 0.9705882352941176 0.0056712945639474 0.801628206859446 0.4036497507116967 0.7959569122954986 0 0 0 0 K00863 0.0 0.1082621082621082 DAK, TKFC; triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15] path:map00051,path:map00561,path:map00680,path:map01100,path:map01120,path:map01200,path:map04622 Fructose and mannose metabolism,Glycerolipid metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,RIG-I-like receptor signaling pathway 283.0 42.0 38.0 4.0 0.857142857142857 G 0.0 49.0 3.0 0.857142857142857 COG2376 Dihydroxyacetone_kinase DAK1 49.0 0.0 1.0 0.0557538209374826 0.454941785263385 0.2553478031004338 0.3991879643259024 0 0 0 0 K00864 0.2085714285714285 0.584045584045584 glpK, GK; glycerol kinase [EC:2.7.1.30] path:map00561,path:map01100,path:map03320,path:map04626 Glycerolipid metabolism,Metabolic pathways,PPAR signaling pathway,Plant-pathogen interaction 362.0 182.0 69.0 4.0 0.535294117647059 F 92.0 248.0 1.0 1.0 COG0554 Glycerol_kinase GlpK 340.0 0.2705882352941176 0.7294117647058823 0.478271453154197 0.506350823982862 0.4923111385685295 0.028079370828665 0 0 0 0 K00865 0.0 0.3105413105413105 glxK, garK; glycerate 2-kinase [EC:2.7.1.165] path:map00260,path:map00561,path:map00630,path:map01100,path:map01110,path:map01120 Glycine, serine and threonine metabolism,Glycerolipid metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 264.0 124.0 123.0 2.0 0.992 G 0.0 126.0 2.0 0.992063492063492 COG1929 Glycerate_kinase GlxK 126.0 0.0 1.0 0.0351057464217686 0.24229540903313 0.1387005777274493 0.2071896626113614 0 0 0 0 K00867 0.02 0.1396011396011396 coaA; type I pantothenate kinase [EC:2.7.1.33] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 270.0 30.0 3.0 2.0 0.526315789473684 H 7.0 50.0 2.0 0.964912280701754 COG1072 Panthothenate_kinase CoaA 57.0 0.1228070175438596 0.8771929824561403 0.0063870700691768 0.0114680848745406 0.0089275774718587 0.0050810148053638 0 0 0 0 K00868 0.02 0.245014245014245 pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 113.0 110.0 0.0 1.0 1.0 H 7.0 103.0 2.0 0.590909090909091 COG2240 Pyridoxal/pyridoxine/pyridoxamine_kinase PdxK 110.0 0.0636363636363636 0.9363636363636364 0.0017516170249152 0.0547492795720944 0.0282504482985047 0.0529976625471792 0 0 0 0 K00869 0.72 0.1481481481481481 MVK, mvaK1; mevalonate kinase [EC:2.7.1.36] path:map00900,path:map01100,path:map01110,path:map04146 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Peroxisome 94.0 195.0 75.0 6.0 0.598159509202454 I 263.0 63.0 3.0 0.98159509202454 COG1577 Mevalonate_kinase ERG12 326.0 0.8067484662576687 0.1932515337423312 0.51050001277129 0.554681807165781 0.5325909099685355 0.0441817943944909 0 1 0 1 K00870 0.0285714285714285 0.0142450142450142 162.0 14.0 3.0 3.0 0.538461538461538 KLT 12.0 12.0 2.0 0.846153846153846 COG0515 Serine/threonine_protein_kinase SPS1 24.0 0.5 0.5 0 0 0 0 K00872 0.3885714285714285 0.433048433048433 thrB; homoserine kinase [EC:2.7.1.39] path:map00260,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 133.0 238.0 190.0 3.0 0.815068493150685 E 138.0 154.0 2.0 0.996575342465753 COG0083 Homoserine_kinase ThrB 292.0 0.4726027397260274 0.5273972602739726 0.138482008810018 0.27224699788696 0.205364503348489 0.133764989076942 0 0 0 0 K00873 0.4714285714285714 0.8490028490028491 PK, pyk; pyruvate kinase [EC:2.7.1.40] path:map00010,path:map00620,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map04922,path:map04930,path:map05165,path:map05203,path:map05230 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Glucagon signaling pathway,Type II diabetes mellitus,Human papillomavirus infection,Viral carcinogenesis,Central carbon metabolism in cancer 229.0 511.0 499.0 4.0 0.969639468690702 G 174.0 353.0 3.0 0.979127134724858 COG0469 Pyruvate_kinase PykF 527.0 0.3301707779886148 0.6698292220113852 0.0004011993941744 0.000766399728364 0.0005837995612692 0.0003652003341896 0 0 0 0 K00874 0.1714285714285714 0.3532763532763532 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 138.0 241.0 236.0 3.0 0.975708502024292 G 78.0 169.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 247.0 0.3157894736842105 0.6842105263157895 0.35462633014929 0.510170160868843 0.4323982455090665 0.155543830719553 0 0 0 0 K00875 0.0 0.0085470085470085 rbtK, FGGY; D-ribulokinase [EC:2.7.1.47] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 523.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG1069 Ribulose_kinase AraB 3.0 0.0 1.0 0 0 0 0 K00876 0.1142857142857142 0.4586894586894587 udk, UCK; uridine kinase [EC:2.7.1.48] path:map00240,path:map00983,path:map01100,path:map01232 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 95.0 233.0 210.0 7.0 0.882575757575757 F 41.0 222.0 7.0 0.848484848484849 COG0572 Uridine_kinase Udk 263.0 0.155893536121673 0.844106463878327 0.308400944477246 0.153078412983035 0.2307396787301405 0.1553225314942109 0 0 0 0 K00878 0.1942857142857142 0.2364672364672364 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50] path:map00730,path:map00740,path:map01100,path:map01240 Thiamine metabolism,Riboflavin metabolism,Metabolic pathways,Biosynthesis of cofactors 178.0 148.0 137.0 4.0 0.919254658385093 H 71.0 90.0 4.0 0.981366459627329 COG2145 Hydroxyethylthiazole_kinase,_sugar_kinase_family ThiM 161.0 0.4409937888198758 0.5590062111801242 0.0376660561899565 0.304256715480798 0.1709613858353772 0.2665906592908415 0 0 0 0 K00879 0.0171428571428571 0.0341880341880341 fucK; L-fuculokinase [EC:2.7.1.51] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 404.0 14.0 12.0 3.0 0.777777777777778 G 6.0 12.0 1.0 1.0 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 18.0 0.3333333333333333 0.6666666666666666 0.264942586488543 0.585132916191273 0.4250377513399079 0.3201903297027299 0 0 0 0 K00880 0.0228571428571428 0.0341880341880341 lyxK; L-xylulokinase [EC:2.7.1.53] path:map00040,path:map00053,path:map01100 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways 370.0 23.0 0.0 1.0 1.0 G 9.0 14.0 1.0 1.0 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 23.0 0.391304347826087 0.6086956521739131 0.132863673016778 0.890686549876512 0.511775111446645 0.7578228768597339 0 0 0 0 K00881 0.0 0.0142450142450142 alsK; allose kinase [EC:2.7.1.55] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 271.0 4.0 2.0 2.0 0.666666666666667 GK 0.0 6.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 6.0 0.0 1.0 0.0455225610724788 0.0824312896662061 0.0639769253693424 0.0369087285937273 0 0 0 0 K00882 0.0457142857142857 0.2535612535612536 fruK; 1-phosphofructokinase [EC:2.7.1.56] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 148.0 92.0 49.0 3.0 0.676470588235294 H 19.0 117.0 1.0 1.0 COG1105 1-phosphofructokinase_or_6-phosphofructokinase_II FruK 136.0 0.1397058823529411 0.8602941176470589 0.678374884166391 0.556531678126424 0.6174532811464075 0.121843206039967 0 1 0 1 K00883 0.0 0.0569800569800569 dgoK; 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 240.0 22.0 21.0 2.0 0.956521739130435 G 0.0 23.0 1.0 1.0 COG3734 2-keto-3-deoxy-galactonokinase DgoK 23.0 0.0 1.0 0.0225092606128295 0.0333792684127805 0.027944264512805 0.010870007799951 0 0 0 0 K00884 0.0714285714285714 0.0712250712250712 NAGK, nagK; N-acetylglucosamine kinase [EC:2.7.1.59] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 116.0 31.0 18.0 4.0 0.543859649122807 G 30.0 27.0 2.0 0.543859649122807 COG2971 BadF-type_ATPase,_related_to_human_N-acetylglucosamine_kinase BadF 57.0 0.5263157894736842 0.4736842105263157 0.369449743434294 0.0876153895180636 0.2285325664761787 0.2818343539162304 0 0 0 0 K00885 0.0 0.0256410256410256 nanK; N-acylmannosamine kinase [EC:2.7.1.60] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 277.0 6.0 3.0 2.0 0.666666666666667 GK 0.0 9.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 9.0 0.0 1.0 0.0156527023053625 0.0301321046688277 0.0228924034870951 0.0144794023634652 0 0 0 0 K00886 0.0028571428571428 0.1424501424501424 ppgK; polyphosphate glucokinase [EC:2.7.1.63] path:map00010,path:map00520,path:map01100,path:map01110,path:map01120,path:map01200,path:map01250 Glycolysis / Gluconeogenesis,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of nucleotide sugars 182.0 56.0 54.0 2.0 0.96551724137931 GK 1.0 57.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 58.0 0.0172413793103448 0.9827586206896552 0.0071134396240193 0.169174035323718 0.0881437374738686 0.1620605956996987 0 0 0 0 K00887 0.0028571428571428 0.2222222222222222 dgkA; undecaprenol kinase [EC:2.7.1.66] path:map00550 Peptidoglycan biosynthesis 101.0 68.0 57.0 3.0 0.85 M 1.0 79.0 2.0 0.8625 COG0818 Diacylglycerol_kinase DgkA 80.0 0.0125 0.9875 0.0554469699908171 0.178755140223613 0.117101055107215 0.1233081702327958 0 0 0 0 K00891 0.56 0.7407407407407407 aroK, aroL; shikimate kinase [EC:2.7.1.71] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 5.0 314.0 96.0 4.0 0.575091575091575 E 247.0 294.0 9.0 0.580586080586081 COG0703 Shikimate_kinase AroK 541.0 0.4565619223659889 0.5434380776340111 0.0796505327555656 0.0562671600642281 0.0679588464098968 0.0233833726913375 0 0 0 0 K00892 0.02 0.0341880341880341 gsk; inosine kinase [EC:2.7.1.73] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 250.0 19.0 18.0 2.0 0.95 G 7.0 13.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 20.0 0.35 0.65 0.21608693657444 0.662768657453437 0.4394277970139385 0.446681720878997 0 0 0 0 K00893 0.0 0.0056980056980056 DCK; deoxycitidine/deoxyadenosine/deoxyguanosine kinase [EC:2.7.1.74 2.7.1.76 2.7.1.113] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 194.0 2.0 0.0 1.0 1.0 F 0.0 2.0 1.0 1.0 COG1428 Deoxyadenosine/deoxycytidine_kinase Dck 2.0 0.0 1.0 0 0 0 0 K00895 0.0085714285714285 0.1082621082621082 pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90] path:map00010,path:map00030,path:map00051,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 318.0 25.0 11.0 3.0 0.595238095238095 G 3.0 39.0 1.0 1.0 COG0205 6-phosphofructokinase PfkA 42.0 0.0714285714285714 0.9285714285714286 0.0293307338155192 0.206284971245271 0.1178078525303951 0.1769542374297518 0 0 0 0 K00897 0.0057142857142857 0.0256410256410256 aphA; kanamycin kinase [EC:2.7.1.95] 226.0 9.0 7.0 2.0 0.818181818181818 J 2.0 9.0 1.0 1.0 COG3231 Aminoglycoside_phosphotransferase Aph 11.0 0.1818181818181818 0.8181818181818182 0.339846385352623 0.713178334623816 0.5265123599882195 0.3733319492711929 0 0 0 0 K00899 0.0 0.0854700854700854 mtnK; 5-methylthioribose kinase [EC:2.7.1.100] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 275.0 19.0 12.0 5.0 0.542857142857143 S 0.0 35.0 1.0 1.0 COG4857 5-Methylthioribose/5-deoxyribose_kinase,_methionine_salvage_pathway MthN 35.0 0.0 1.0 0.0256840496810373 0.0900009172069742 0.0578424834440057 0.0643168675259369 0 0 0 0 K00901 0.0057142857142857 0.4672364672364672 dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107] path:map00561,path:map00564,path:map01100,path:map01110,path:map04070,path:map04072,path:map04361,path:map05231 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Phosphatidylinositol signaling system,Phospholipase D signaling pathway,Axon regeneration,Choline metabolism in cancer 87.0 155.0 140.0 3.0 0.895953757225434 M 2.0 171.0 2.0 0.884393063583815 COG0818 Diacylglycerol_kinase DgkA 173.0 0.0115606936416184 0.9884393063583816 0.103331466205514 0.60024741598827 0.351789441096892 0.496915949782756 0 0 0 0 K00903 0.0 0.0227920227920227 epsB, capB; protein-tyrosine kinase [EC:2.7.10.3] 215.0 8.0 0.0 1.0 1.0 D 0.0 8.0 1.0 1.0 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 8.0 0.0 1.0 0.0642917321876223 0.0920932182484981 0.0781924752180601 0.0278014860608758 0 0 0 0 K00906 0.0 0.0541310541310541 aceK; isocitrate dehydrogenase kinase/phosphatase [EC:2.7.11.5 3.1.3.-] 508.0 15.0 11.0 2.0 0.789473684210526 F 0.0 19.0 1.0 1.0 COG4579 Isocitrate_dehydrogenase_kinase/phosphatase AceK 19.0 0.0 1.0 0.0253029142634735 0.0831890469644249 0.0542459806139492 0.0578861327009514 0 0 0 0 K00912 0.02 0.5213675213675214 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 92.0 127.0 73.0 5.0 0.638190954773869 M 7.0 193.0 3.0 0.91 COG1663 Tetraacyldisaccharide-1-P_4'-kinase_(Lipid_A_4'-kinase) LpxK 200.0 0.035 0.965 0.0960120454719124 0.0772585665422396 0.086635306007076 0.0187534789296728 0 0 0 0 K00913 0.0028571428571428 0.0 ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134] path:map00562,path:map01100,path:map04070 Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system 298.0 1.0 0.0 1.0 1.0 G 1.0 0.0 1.0 1.0 28IF7 1.0 1.0 0.0 0 0 0 0 K00917 0.0 0.1054131054131054 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 202.0 26.0 15.0 3.0 0.634146341463415 H 0.0 41.0 1.0 1.0 COG1105 1-phosphofructokinase_or_6-phosphofructokinase_II FruK 41.0 0.0 1.0 0.64353700313593 0.592084557643299 0.6178107803896145 0.0514524454926309 0 0 0 1 K00918 0.1228571428571428 0.0056980056980056 pfkC; ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147] path:map00010,path:map00030,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 265.0 63.0 0.0 1.0 1.0 G 61.0 2.0 1.0 1.0 COG4809 Archaeal_ADP-dependent_glucokinase/phosphofructokinase Pfk2 63.0 0.9682539682539684 0.0317460317460317 0.446415729083689 0.910331178479301 0.6783734537814949 0.463915449395612 0 0 0 0 K00919 0.0057142857142857 0.7777777777777778 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 89.0 152.0 29.0 3.0 0.550724637681159 F 2.0 274.0 1.0 1.0 COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol_kinase IspE 276.0 0.0072463768115942 0.9927536231884058 0.0135317117714775 0.273740598477236 0.1436361551243567 0.2602088867057585 0 0 0 0 K00925 0.04 0.6068376068376068 ackA; acetate kinase [EC:2.7.2.1] path:map00430,path:map00620,path:map00640,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Taurine and hypotaurine metabolism,Pyruvate metabolism,Propanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 280.0 122.0 37.0 4.0 0.442028985507246 F 15.0 261.0 2.0 0.996376811594203 COG0282 Acetate_kinase AckA 276.0 0.0543478260869565 0.9456521739130436 0.851749198864586 0.0155669248744075 0.4336580618694967 0.8361822739901785 1 1 1 1 K00926 0.3057142857142857 0.2564102564102564 arcC; carbamate kinase [EC:2.7.2.2] path:map00220,path:map00230,path:map00910,path:map01100,path:map01120,path:map01200 Arginine biosynthesis,Purine metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 207.0 212.0 205.0 2.0 0.968036529680365 E 113.0 106.0 2.0 0.968036529680365 COG0549 Carbamate_kinase ArcC 219.0 0.5159817351598174 0.4840182648401826 0.83046928288788 0.960530761064824 0.895500021976352 0.130061478176944 1 1 1 1 K00927 0.8171428571428572 0.9743589743589745 PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3] path:map00010,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map04066 Glycolysis / Gluconeogenesis,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,HIF-1 signaling pathway 222.0 337.0 10.0 3.0 0.506006006006006 F 304.0 362.0 2.0 0.995495495495496 COG0126 3-phosphoglycerate_kinase Pgk 666.0 0.4564564564564564 0.5435435435435435 0.069022353668511 0.330996668723028 0.2000095111957695 0.261974315054517 0 0 0 0 K00928 0.6057142857142858 0.8490028490028491 lysC; aspartate kinase [EC:2.7.2.4] path:map00260,path:map00261,path:map00270,path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Glycine, serine and threonine metabolism,Monobactam biosynthesis,Cysteine and methionine metabolism,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 205.0 636.0 0.0 1.0 1.0 E 245.0 391.0 3.0 0.988993710691824 COG0527 Aspartate_kinase MetL1 636.0 0.3852201257861635 0.6147798742138365 0.014136456517358 0.0634915257051703 0.0388139911112641 0.0493550691878123 0 0 0 0 K00929 0.0057142857142857 0.1595441595441595 buk; butyrate kinase [EC:2.7.2.7] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 285.0 47.0 8.0 3.0 0.505376344086022 C 2.0 91.0 2.0 0.989247311827957 COG3426 Butyrate_kinase Buk 93.0 0.021505376344086 0.978494623655914 0.899145900096147 0.0917517175083925 0.4954488088022697 0.8073941825877545 0 0 1 1 K00930 0.2485714285714285 0.7435897435897436 argB; acetylglutamate kinase [EC:2.7.2.8] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 167.0 265.0 167.0 3.0 0.690104166666667 E 89.0 295.0 4.0 0.924479166666667 COG0548 N-acetylglutamate_kinase ArgB 384.0 0.2317708333333333 0.7682291666666666 0.193776586272347 0.747371416606398 0.4705740014393725 0.553594830334051 0 0 0 0 K00931 0.1571428571428571 0.7037037037037037 proB; glutamate 5-kinase [EC:2.7.2.11] path:map00330,path:map00332,path:map01100,path:map01110,path:map01230 Arginine and proline metabolism,Carbapenem biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 160.0 247.0 182.0 3.0 0.781645569620253 E 57.0 259.0 2.0 0.987341772151899 COG0263 Glutamate_5-kinase ProB 316.0 0.180379746835443 0.819620253164557 0.0845762327742325 0.719217850938452 0.4018970418563423 0.6346416181642195 0 0 0 0 K00932 0.0 0.0085470085470085 tdcD; propionate kinase [EC:2.7.2.15] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 384.0 4.0 0.0 1.0 1.0 F 0.0 4.0 1.0 1.0 COG0282 Acetate_kinase AckA 4.0 0.0 1.0 0.118276129271601 0.184691558940221 0.1514838441059109 0.0664154296686199 0 0 0 0 K00933 0.0 0.0341880341880341 E2.7.3.2; creatine kinase [EC:2.7.3.2] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 248.0 9.0 6.0 2.0 0.75 E 0.0 12.0 1.0 1.0 COG3869 Protein-arginine_kinase_McsB McsB 12.0 0.0 1.0 0.862320354820896 0.806983001811222 0.8346516783160589 0.055337353009674 0 0 1 1 K00934 0.0 0.0256410256410256 E2.7.3.3; arginine kinase [EC:2.7.3.3] path:map00330 Arginine and proline metabolism 248.0 7.0 5.0 2.0 0.777777777777778 E 0.0 9.0 1.0 1.0 COG3869 Protein-arginine_kinase_McsB McsB 9.0 0.0 1.0 0.916661692305453 0.681559566986303 0.7991106296458781 0.2351021253191499 0 0 1 1 K00936 0.0257142857142857 0.1709401709401709 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3] 160.0 86.0 85.0 2.0 0.988505747126437 T 10.0 77.0 13.0 0.609195402298851 COG3920 Two-component_sensor_histidine_kinase,_HisKA_and_HATPase_domains 87.0 0.1149425287356321 0.8850574712643678 0.147838659249176 0.218034410961107 0.1829365351051415 0.070195751711931 0 0 0 0 K00937 0.1571428571428571 0.5413105413105413 ppk1; polyphosphate kinase [EC:2.7.4.1] path:map00190,path:map03018 Oxidative phosphorylation,RNA degradation 401.0 187.0 124.0 8.0 0.670250896057348 P 66.0 213.0 6.0 0.931899641577061 COG0855 Polyphosphate_kinase Ppk 279.0 0.2365591397849462 0.7634408602150538 0.0226672746049334 0.174038003150023 0.0983526388774782 0.1513707285450896 0 0 0 0 K00938 0.0542857142857142 0.0626780626780626 E2.7.4.2, mvaK2; phosphomevalonate kinase [EC:2.7.4.2] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 131.0 40.0 38.0 3.0 0.909090909090909 I 19.0 25.0 2.0 0.75 COG1577 Mevalonate_kinase ERG12 44.0 0.4318181818181818 0.5681818181818182 0.0054529962426055 0.0347583365334756 0.0201056663880405 0.02930534029087 0 0 0 0 K00939 0.8857142857142857 0.9857549857549858 adk, AK; adenylate kinase [EC:2.7.4.3] path:map00230,path:map00730,path:map01100,path:map01110,path:map01232,path:map01240 Purine metabolism,Thiamine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism,Biosynthesis of cofactors 37.0 740.0 0.0 1.0 1.0 F 355.0 408.0 6.0 0.729057591623037 COG0563 Adenylate_kinase_or_related_kinase Adk 763.0 0.4652686762778505 0.5347313237221494 0.200087470191899 0.175126106827577 0.187606788509738 0.0249613633643219 0 0 0 0 K00940 0.8514285714285714 0.8433048433048433 ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] path:map00230,path:map00240,path:map00983,path:map01100,path:map01110,path:map01232,path:map01240,path:map04016 Purine metabolism,Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism,Biosynthesis of cofactors,MAPK signaling pathway - plant 103.0 610.0 0.0 1.0 1.0 F 304.0 306.0 1.0 1.0 COG0105 Nucleoside_diphosphate_kinase Ndk 610.0 0.4983606557377049 0.5016393442622951 0.0182207687355485 0.646252820806509 0.3322367947710287 0.6280320520709606 0 0 0 0 K00941 0.4542857142857143 0.6495726495726496 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 114.0 422.0 417.0 4.0 0.972350230414746 H 169.0 263.0 4.0 0.976958525345622 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine_kinase ThiD 432.0 0.3912037037037037 0.6087962962962963 0.36703516432339 0.417277732733614 0.392156448528502 0.050242568410224 0 0 0 0 K00942 0.0114285714285714 0.9173789173789174 gmk, GUK1; guanylate kinase [EC:2.7.4.8] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 113.0 348.0 347.0 4.0 0.991452991452992 F 4.0 347.0 4.0 0.988603988603989 COG0194 Guanylate_kinase Gmk 351.0 0.0113960113960113 0.9886039886039886 0.585805272647362 0.800535309946418 0.69317029129689 0.2147300372990559 0 1 0 1 K00943 0.8657142857142858 0.8746438746438746 tmk, DTYMK; dTMP kinase [EC:2.7.4.9] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 16.0 739.0 732.0 3.0 0.985333333333333 F 390.0 359.0 3.0 0.981358189081225 COG0125 Thymidylate_kinase Tmk 749.0 0.520694259012016 0.4793057409879839 0.11678510378304 0.424416420602418 0.270600762192729 0.307631316819378 0 0 0 0 K00945 0.78 0.7977207977207977 cmk; CMP/dCMP kinase [EC:2.7.4.25] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 59.0 594.0 582.0 4.0 0.973770491803279 F 293.0 317.0 6.0 0.518032786885246 COG1102 Cytidylate_kinase CmkB 610.0 0.480327868852459 0.519672131147541 0.365816433955215 0.56293393711319 0.4643751855342025 0.1971175031579749 0 0 0 0 K00946 0.6428571428571429 0.6182336182336182 thiL; thiamine-monophosphate kinase [EC:2.7.4.16] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 87.0 425.0 392.0 2.0 0.927947598253275 H 233.0 224.0 1.0 1.0 COG0611 Thiamine_monophosphate_kinase ThiL 457.0 0.5098468271334792 0.4901531728665207 0.0462175631076515 0.063557151682013 0.0548873573948322 0.0173395885743614 0 0 0 0 K00947 0.0314285714285714 0.0512820512820512 mosAB; molybdenum storage protein 205.0 33.0 0.0 1.0 1.0 F 12.0 21.0 1.0 1.0 COG0528 Uridylate_kinase PyrH 33.0 0.3636363636363636 0.6363636363636364 0.0307675967093142 0.31979879974799 0.1752831982286521 0.2890312030386758 0 0 0 0 K00948 0.8171428571428572 0.9287749287749288 PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] path:map00030,path:map00230,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 114.0 642.0 566.0 3.0 0.892906815020862 F 322.0 397.0 1.0 1.0 COG0462 Phosphoribosylpyrophosphate_synthetase PrsA 719.0 0.4478442280945758 0.5521557719054242 0.42198805670435 0.899187809056953 0.6605879328806514 0.4771997523526029 0 0 0 0 K00949 0.0714285714285714 0.3447293447293447 thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 73.0 140.0 130.0 3.0 0.927152317880795 H 25.0 126.0 4.0 0.913907284768212 COG1564 Thiamine_pyrophosphokinase ThiN 151.0 0.1655629139072847 0.8344370860927153 0.0146372700965051 0.125047321344373 0.069842295720439 0.1104100512478678 0 0 0 0 K00950 0.0057142857142857 0.8091168091168092 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 25.0 308.0 295.0 4.0 0.922155688622754 H 2.0 332.0 9.0 0.907185628742515 COG0801 7,8-dihydro-6-hydroxymethylpterin_pyrophosphokinase_(folate_biosynthesis) FolK 334.0 0.0059880239520958 0.994011976047904 0.482546645638105 0.773364240177668 0.6279554429078865 0.290817594539563 0 0 0 0 K00951 0.1028571428571428 0.8575498575498576 relA; GTP pyrophosphokinase [EC:2.7.6.5] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 272.0 403.0 399.0 5.0 0.978155339805825 KT 47.0 364.0 2.0 0.990291262135922 COG0317 (p)ppGpp_synthase/hydrolase,_HD_superfamily SpoT 411.0 0.1143552311435523 0.8856447688564477 0.429388574123028 0.491266388838506 0.4603274814807669 0.0618778147154779 0 0 0 0 K00952 0.7285714285714285 0.0341880341880341 nadM; nicotinamide-nucleotide adenylyltransferase [EC:2.7.7.1] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 108.0 178.0 46.0 2.0 0.574193548387097 F 298.0 12.0 1.0 1.0 COG1056 Nicotinamide_mononucleotide_adenylyltransferase NadR 310.0 0.9612903225806452 0.0387096774193548 0.873502108398508 0.913761957549594 0.893632032974051 0.040259849151086 1 1 1 1 K00953 0.0 0.0028490028490028 FLAD1; FAD synthetase [EC:2.7.7.2] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 257.0 1.0 0.0 1.0 1.0 EH 0.0 1.0 1.0 1.0 COG0175 3'-phosphoadenosine_5'-phosphosulfate_sulfotransferase_(PAPS_reductase)/FAD_synthetase_or_related_enzyme CysD 1.0 0.0 1.0 0 0 0 0 K00954 0.02 0.8746438746438746 E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 108.0 264.0 209.0 3.0 0.819875776397515 H 7.0 315.0 2.0 0.990683229813665 COG0669 Phosphopantetheine_adenylyltransferase CoaD 322.0 0.0217391304347826 0.9782608695652174 0.310670065128231 0.486990422707989 0.3988302439181099 0.176320357579758 0 0 0 0 K00955 0.0371428571428571 0.2763532763532763 cysNC; bifunctional enzyme CysN/CysC [EC:2.7.7.4 2.7.1.25] path:map00230,path:map00261,path:map00450,path:map00920,path:map01100,path:map01110,path:map01120 Purine metabolism,Monobactam biosynthesis,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 332.0 92.0 52.0 3.0 0.638888888888889 P 13.0 111.0 2.0 0.583333333333333 COG0529 Adenylylsulfate_kinase_or_related_kinase CysC 124.0 0.1048387096774193 0.8951612903225806 0.0541746038509614 0.193512355480453 0.1238434796657072 0.1393377516294916 0 0 0 0 K00956 0.04 0.2621082621082621 cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] path:map00230,path:map00261,path:map00450,path:map00920,path:map01100,path:map01110,path:map01120 Purine metabolism,Monobactam biosynthesis,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 349.0 80.0 45.0 3.0 0.689655172413793 P 14.0 102.0 5.0 0.767241379310345 COG2895 Sulfate_adenylyltransferase_subunit_1,_EFTu-like_GTPase_family CysN 116.0 0.1206896551724138 0.8793103448275862 0.363085966226126 0.31170706847313 0.337396517349628 0.0513788977529959 0 0 0 0 K00957 0.0657142857142857 0.339031339031339 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] path:map00230,path:map00261,path:map00450,path:map00920,path:map01100,path:map01110,path:map01120 Purine metabolism,Monobactam biosynthesis,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 246.0 112.0 69.0 4.0 0.708860759493671 EH 24.0 134.0 2.0 0.987341772151899 COG0175 3'-phosphoadenosine_5'-phosphosulfate_sulfotransferase_(PAPS_reductase)/FAD_synthetase_or_related_enzyme CysD 158.0 0.1518987341772152 0.8481012658227848 0.734448294792106 0.62094498664751 0.677696640719808 0.113503308144596 0 1 0 1 K00958 0.22 0.3048433048433048 sat, met3; sulfate adenylyltransferase [EC:2.7.7.4] path:map00230,path:map00261,path:map00450,path:map00920,path:map01100,path:map01110,path:map01120 Purine metabolism,Monobactam biosynthesis,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 182.0 144.0 71.0 4.0 0.610169491525424 P 99.0 136.0 3.0 0.686440677966102 COG2046 ATP_sulfurylase_(sulfate_adenylyltransferase) MET3 235.0 0.4212765957446808 0.5787234042553191 0.799009597758601 0.95242201326265 0.8757158055106256 0.1534124155040489 1 1 1 1 K00960 0.18 0.0512820512820512 rpo13; DNA-directed RNA polymerase subunit 13 [EC:2.7.7.6] path:map03020 RNA polymerase 27.0 6.0 0.0 3.0 0.375 K 89.0 18.0 5.0 0.850467289719626 arCOG03272 107.0 0.8317757009345794 0.1682242990654205 0.185626811756329 0.0142613110657223 0.0999440614110256 0.1713655006906067 0 0 0 0 K00962 0.0 0.9743589743589745 pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] path:map03018 RNA degradation 542.0 354.0 0.0 1.0 1.0 J 0.0 354.0 1.0 1.0 COG1185 Polyribonucleotide_nucleotidyltransferase_(polynucleotide_phosphorylase) Pnp 354.0 0.0 1.0 0.831355881333157 0.967586337709058 0.8994711095211074 0.136230456375901 0 0 1 1 K00963 0.2114285714285714 0.6210826210826211 UGP2, galU, galF; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] path:map00040,path:map00052,path:map00500,path:map00520,path:map00541,path:map01100,path:map01110,path:map01240,path:map01250 Pentose and glucuronate interconversions,Galactose metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Biosynthesis of nucleotide sugars 125.0 312.0 290.0 4.0 0.861878453038674 M 82.0 280.0 5.0 0.859116022099448 COG1210 UTP-glucose-1-phosphate_uridylyltransferase GalU 362.0 0.2265193370165746 0.7734806629834254 0.233770514331748 0.919781905103672 0.57677620971771 0.686011390771924 0 0 0 0 K00965 0.2714285714285714 0.4188034188034188 galT, GALT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12] path:map00052,path:map00520,path:map01100,path:map01250,path:map04917 Galactose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars,Prolactin signaling pathway 130.0 172.0 110.0 3.0 0.625454545454546 C 106.0 169.0 3.0 0.876363636363636 COG1085 Galactose-1-phosphate_uridylyltransferase GalT 275.0 0.3854545454545454 0.6145454545454545 0.919509090987738 0.947409875970428 0.933459483479083 0.0279007849826899 1 1 1 1 K00966 0.5542857142857143 0.3532763532763532 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] path:map00051,path:map00520,path:map01100,path:map01110,path:map01240,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Biosynthesis of nucleotide sugars 40.0 247.0 121.0 5.0 0.599514563106796 M 263.0 148.0 3.0 0.890776699029126 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 411.0 0.6399026763990268 0.3600973236009732 0.221144159867417 0.238811093425943 0.22997762664668 0.017666933558526 0 0 0 0 K00968 0.0 0.0256410256410256 PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] path:map00440,path:map00564,path:map01100,path:map05231 Phosphonate and phosphinate metabolism,Glycerophospholipid metabolism,Metabolic pathways,Choline metabolism in cancer 117.0 5.0 1.0 3.0 0.5 IM 0.0 10.0 1.0 1.0 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 10.0 0.0 1.0 0.030718846008222 0.2084936458564 0.119606245932311 0.177774799848178 0 0 0 0 K00969 0.0057142857142857 0.8660968660968661 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 12.0 320.0 290.0 3.0 0.881542699724518 H 2.0 360.0 3.0 0.884297520661157 COG1057 Nicotinate-nucleotide_adenylyltransferase_NadD NadD 362.0 0.005524861878453 0.994475138121547 0.104025543678086 0.371078695501324 0.237552119589705 0.2670531518232379 0 0 0 0 K00970 0.0342857142857142 0.7749287749287749 pcnB; poly(A) polymerase [EC:2.7.7.19] path:map03018 RNA degradation 56.0 244.0 148.0 5.0 0.683473389355742 J 13.0 343.0 5.0 0.873949579831933 COG0617 tRNA_nucleotidyltransferase/poly(A)_polymerase PcnB 356.0 0.0365168539325842 0.9634831460674156 0.0852351375783104 0.0923839666601518 0.0888095521192311 0.0071488290818414 0 0 0 0 K00971 0.0914285714285714 0.5868945868945868 manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] path:map00051,path:map00520,path:map00541,path:map01100,path:map01110,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 154.0 232.0 203.0 6.0 0.805555555555556 M 38.0 248.0 6.0 0.694444444444444 COG0836 Mannose-1-phosphate_guanylyltransferase CpsB 286.0 0.1328671328671328 0.8671328671328671 0.0081284267611692 0.649370503891293 0.3287494653262311 0.6412420771301238 0 0 0 0 K00972 0.0057142857142857 0.0655270655270655 UAP1; UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:2.7.7.23 2.7.7.83] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 248.0 14.0 2.0 2.0 0.538461538461538 G 2.0 24.0 2.0 0.538461538461538 COG4284 UDP-N-acetylglucosamine_pyrophosphorylase QRI1 26.0 0.0769230769230769 0.9230769230769232 0.0081317342656671 0.0180671959619309 0.0130994651137989 0.0099354616962638 0 0 0 0 K00973 0.7257142857142858 0.7407407407407407 rfbA, rmlA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] path:map00521,path:map00523,path:map00525,path:map00541,path:map01100,path:map01110,path:map01250 Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,Acarbose and validamycin biosynthesis,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 44.0 783.0 668.0 4.0 0.812240663900415 M 568.0 391.0 6.0 0.532157676348548 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 959.0 0.5922836287799792 0.4077163712200208 0.0138427419958222 0.0038223036113992 0.0088325228036107 0.010020438384423 0 0 0 0 K00974 0.12 0.8803418803418803 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-] 83.0 300.0 198.0 7.0 0.666666666666667 J 51.0 399.0 14.0 0.744444444444445 COG0617 tRNA_nucleotidyltransferase/poly(A)_polymerase PcnB 450.0 0.1133333333333333 0.8866666666666667 0.811804165046106 0.0520159988537268 0.4319100819499163 0.7597881661923792 1 1 1 1 K00975 0.0085714285714285 0.4757834757834758 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27] path:map00500,path:map00520,path:map01100,path:map01110,path:map01250,path:map02026 Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars,Biofilm formation - Escherichia coli 239.0 155.0 74.0 4.0 0.630081300813008 H 3.0 243.0 2.0 0.991869918699187 COG0448 Glucose-1-phosphate_adenylyltransferase_(ADP-glucose_pyrophosphorylase) GlgC 246.0 0.0121951219512195 0.9878048780487804 0.369834832630206 0.432113763895526 0.400974298262866 0.06227893126532 0 0 0 0 K00978 0.0542857142857142 0.2592592592592592 rfbF; glucose-1-phosphate cytidylyltransferase [EC:2.7.7.33] path:map00500,path:map00520,path:map00541,path:map01100,path:map01250 Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 211.0 103.0 87.0 3.0 0.858333333333333 JM 19.0 101.0 1.0 1.0 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 120.0 0.1583333333333333 0.8416666666666667 0.40880338051617 0.389548425955185 0.3991759032356775 0.0192549545609849 0 0 0 0 K00979 0.0085714285714285 0.5270655270655271 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 158.0 163.0 144.0 5.0 0.815 M 3.0 197.0 3.0 0.975 COG1212 CMP-2-keto-3-deoxyoctulosonic_acid_synthetase KdsB 200.0 0.015 0.985 0.0016358712316469 0.0067845849770398 0.0042102281043433 0.0051487137453929 0 0 0 0 K00980 0.1085714285714285 0.1025641025641025 tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] path:map00564 Glycerophospholipid metabolism 71.0 26.0 1.0 5.0 0.320987654320988 H 42.0 39.0 1.0 1.0 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 81.0 0.5185185185185185 0.4814814814814814 0.800208940379359 0.989339264432265 0.894774102405812 0.189130324052906 1 1 1 1 K00981 0.0 0.8888888888888888 E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] path:map00564,path:map01100,path:map01110,path:map04070 Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Phosphatidylinositol signaling system 46.0 190.0 86.0 3.0 0.56379821958457 S 0.0 337.0 3.0 0.670623145400593 COG4589 Predicted_CDP-diglyceride_synthetase/phosphatidate_cytidylyltransferase YnbB 337.0 0.0 1.0 0.101835111266769 0.247201272695602 0.1745181919811855 0.145366161428833 0 0 0 0 K00982 0.0028571428571428 0.3361823361823361 glnE; [glutamine synthetase] adenylyltransferase / [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase [EC:2.7.7.42 2.7.7.89] 412.0 95.0 70.0 3.0 0.736434108527132 H 1.0 128.0 3.0 0.945736434108527 COG1391 Glutamine_synthetase_adenylyltransferase GlnE1 129.0 0.0077519379844961 0.992248062015504 0.003489065115526 0.0092237411534596 0.0063564031344928 0.0057346760379336 0 0 0 0 K00983 0.0371428571428571 0.2051282051282051 neuA, nnaC; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 94.0 103.0 95.0 4.0 0.887931034482759 M 14.0 98.0 7.0 0.887931034482759 COG1083 CMP-N-acetylneuraminic_acid_synthetase,_NeuA/PseF_family NeuA 112.0 0.125 0.875 0.0775717468117492 0.145487045784394 0.1115293962980716 0.0679152989726448 0 0 0 0 K00984 0.02 0.0484330484330484 "aadA; streptomycin 3""-adenylyltransferase [EC:2.7.7.47]" 57.0 21.0 17.0 2.0 0.84 S 7.0 17.0 1.0 1.0 COG1708 Predicted_nucleotidyltransferase,_MJ0604_family MJ0604 24.0 0.2916666666666667 0.7083333333333334 0.0178546035246356 0.0289911078478637 0.0234228556862496 0.0111365043232281 0 0 0 0 K00986 0.0 0.0 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] 412.0 403.0 5.0 0.971698113207547 L 0.0 0.0 7.0 0.622641509433962 COG3344 Retron-type_reverse_transcriptase YkfC 0.0 0 0 0 0 K00988 0.0 0.037037037037037 APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53] path:map00230,path:map00920,path:map01100,path:map01120 Purine metabolism,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 278.0 13.0 0.0 1.0 1.0 F 0.0 13.0 1.0 1.0 COG4360 ATP_adenylyltransferase_(5',5'''-P-1,P-4-tetraphosphate_phosphorylase_II) APA2 13.0 0.0 1.0 0.0233186666038475 0.0250227528330299 0.0241707097184387 0.0017040862291823 0 0 0 0 K00989 0.0542857142857142 0.5783475783475783 rph; ribonuclease PH [EC:2.7.7.56] 165.0 220.0 216.0 4.0 0.969162995594714 J 19.0 208.0 3.0 0.951541850220264 COG0689 Ribonuclease_PH Rph 227.0 0.0837004405286343 0.9162995594713657 0.305782097843595 0.733822206167821 0.519802152005708 0.428040108324226 0 0 0 0 K00990 0.0028571428571428 0.3304843304843304 glnD; [protein-PII] uridylyltransferase [EC:2.7.7.59] path:map02020 Two-component system 421.0 110.0 91.0 2.0 0.852713178294574 O 1.0 128.0 2.0 0.984496124031008 COG2844 UTP:GlnB_(protein_PII)_uridylyltransferase GlnD 129.0 0.0077519379844961 0.992248062015504 0.0081430817320742 0.0412168704275834 0.0246799760798288 0.0330737886955092 0 0 0 0 K00991 0.0171428571428571 0.584045584045584 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 101.0 223.0 217.0 3.0 0.961206896551724 I 8.0 223.0 4.0 0.926724137931034 COG1211 2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase IspD 231.0 0.0346320346320346 0.9653679653679652 0.0315160641802326 0.305888478960352 0.1687022715702923 0.2743724147801193 0 0 0 0 K00992 0.0 0.1538461538461538 murU; N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase [EC:2.7.7.99] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 150.0 56.0 55.0 2.0 0.982456140350877 JM 0.0 57.0 2.0 0.982456140350877 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 57.0 0.0 1.0 0.0172923420477811 0.0550033632114154 0.0361478526295982 0.0377110211636343 0 0 0 0 K00995 0.3628571428571429 0.8062678062678063 pgsA, PGS1; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 20.0 606.0 594.0 3.0 0.978998384491115 I 159.0 460.0 5.0 0.97092084006462 COG0558 Phosphatidylglycerophosphate_synthase PgsA 619.0 0.2568659127625202 0.7431340872374798 0.0172404143255733 0.280133797452371 0.1486871058889721 0.2628933831267976 0 0 0 0 K00996 0.0028571428571428 0.1396011396011396 rfbP; undecaprenyl-phosphate galactose phosphotransferase [EC:2.7.8.6] 211.0 55.0 0.0 1.0 1.0 M 1.0 54.0 2.0 0.745454545454546 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 55.0 0.0181818181818181 0.9818181818181818 0.803849928357297 0.878157270890664 0.8410035996239804 0.074307342533367 0 0 1 1 K00997 0.0457142857142857 0.6951566951566952 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7] path:map00770,path:map01100 Pantothenate and CoA biosynthesis,Metabolic pathways 37.0 262.0 240.0 4.0 0.909722222222222 I 17.0 271.0 3.0 0.913194444444444 COG0736 Phosphopantetheinyl_transferase_(holo-ACP_synthase) AcpS 288.0 0.0590277777777777 0.9409722222222222 0.0788150990717595 0.657994047879565 0.3684045734756622 0.5791789488078054 0 0 0 0 K00998 0.0 0.0199430199430199 pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] path:map00260,path:map00564,path:map01100,path:map01110 Glycine, serine and threonine metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 448.0 7.0 0.0 1.0 1.0 I 0.0 7.0 1.0 1.0 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin_synthase Cls 7.0 0.0 1.0 0.0005381092386987 0.0022895780166021 0.0014138436276503 0.0017514687779034 0 0 0 0 K00999 0.0028571428571428 0.0769230769230769 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11] path:map00562,path:map00564,path:map01100,path:map04070 Inositol phosphate metabolism,Glycerophospholipid metabolism,Metabolic pathways,Phosphatidylinositol signaling system 185.0 28.0 0.0 1.0 1.0 I 1.0 27.0 1.0 1.0 COG0558 Phosphatidylglycerophosphate_synthase PgsA 28.0 0.0357142857142857 0.9642857142857144 0.0002664991854732 0.0012477796822789 0.000757139433876 0.0009812804968056 0 0 0 0 K01000 0.0228571428571428 0.9572649572649572 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] path:map00550,path:map01100,path:map01502 Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance 193.0 350.0 349.0 2.0 0.997150997150997 M 8.0 343.0 2.0 0.997150997150997 COG0472 UDP-N-acetylmuramyl_pentapeptide_phosphotransferase/UDP-N-acetylglucosamine-1-phosphate_transferase Rfe 351.0 0.0227920227920227 0.9772079772079773 0.962850315603045 0.931835500942394 0.9473429082727196 0.031014814660651 1 1 1 1 K01001 0.54 0.0028490028490028 ALG7; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [EC:2.7.8.15] path:map00510,path:map01100 N-Glycan biosynthesis,Metabolic pathways 178.0 211.0 209.0 2.0 0.990610328638498 M 212.0 1.0 1.0 1.0 COG0472 UDP-N-acetylmuramyl_pentapeptide_phosphotransferase/UDP-N-acetylglucosamine-1-phosphate_transferase Rfe 213.0 0.9953051643192488 0.0046948356807511 0.79565439294444 0.967986701520859 0.8818205472326495 0.172332308576419 0 0 1 1 K01002 0.0114285714285714 0.0398860398860398 mdoB; phosphoglycerol transferase [EC:2.7.8.20] 170.0 21.0 20.0 2.0 0.954545454545455 M 4.0 18.0 3.0 0.636363636363636 COG1368 Phosphoglycerol_transferase_MdoB/OpgB,_AlkP_superfamily MdoB 22.0 0.1818181818181818 0.8181818181818182 0.0321173024849527 0.0920239404074852 0.0620706214462189 0.0599066379225324 0 0 0 0 K01003 0.0 0.0113960113960113 bcpA; oxaloacetate decarboxylase [EC:4.1.1.112] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 267.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG2513 2-Methylisocitrate_lyase_and_related_enzymes,_PEP_mutase_family PrpB 5.0 0.0 1.0 0.0387556228062471 0.143115196498834 0.0909354096525405 0.1043595736925869 0 0 0 0 K01004 0.0028571428571428 0.0512820512820512 pcs; phosphatidylcholine synthase [EC:2.7.8.24] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 206.0 20.0 0.0 1.0 1.0 I 1.0 19.0 1.0 1.0 COG1183 Phosphatidylserine_synthase PssA 20.0 0.05 0.95 0.0035270570154457 0.0165413813100115 0.0100342191627286 0.0130143242945658 0 0 0 0 K01006 0.2857142857142857 0.5641025641025641 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1] path:map00010,path:map00620,path:map00710,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Carbon fixation in photosynthetic organisms,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 510.0 302.0 279.0 3.0 0.870317002881844 G 118.0 229.0 3.0 0.99135446685879 COG0574 Phosphoenolpyruvate_synthase/pyruvate_phosphate_dikinase PpsA 347.0 0.3400576368876081 0.659942363112392 0.279450416603869 0.928020189188637 0.603735302896253 0.6485697725847681 0 0 0 0 K01007 0.8 0.5584045584045584 pps, ppsA; pyruvate, water dikinase [EC:2.7.9.2] path:map00010,path:map00620,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 64.0 550.0 432.0 8.0 0.6900878293601 G 415.0 363.0 9.0 0.867001254705144 COG0574 Phosphoenolpyruvate_synthase/pyruvate_phosphate_dikinase PpsA 778.0 0.5334190231362468 0.4665809768637532 0.700711383020871 0.900516020767701 0.800613701894286 0.19980463774683 0 1 0 1 K01008 0.0628571428571428 0.4045584045584046 selD, SEPHS; selenide, water dikinase [EC:2.7.9.3] path:map00450,path:map01100 Selenocompound metabolism,Metabolic pathways 221.0 83.0 42.0 6.0 0.466292134831461 E 24.0 151.0 4.0 0.848314606741573 COG0709 Selenophosphate_synthase SelD 175.0 0.1371428571428571 0.8628571428571429 0.0129116064476438 0.537521735301546 0.2752166708745949 0.5246101288539022 0 0 0 0 K01011 0.2942857142857142 0.4843304843304843 TST, MPST, sseA; thiosulfate/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2] path:map00270,path:map00920,path:map01100,path:map01120,path:map04122 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Sulfur relay system 40.0 492.0 480.0 7.0 0.935361216730038 P 238.0 287.0 9.0 0.855513307984791 COG2897 3-mercaptopyruvate_sulfurtransferase_SseA,_contains_two_rhodanese_domains SseA 525.0 0.4533333333333333 0.5466666666666666 0.0079963067059159 0.478523599944247 0.2432599533250814 0.4705272932383311 0 0 0 0 K01012 0.3742857142857143 0.6267806267806267 bioB; biotin synthase [EC:2.8.1.6] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 111.0 310.0 233.0 5.0 0.687361419068736 H 156.0 294.0 4.0 0.796008869179601 COG0502 Biotin_synthase_or_related_enzyme BioB 450.0 0.3466666666666667 0.6533333333333333 0.0112799440176747 0.672892935776663 0.3420864398971688 0.6616129917589882 0 0 0 0 K01014 0.0085714285714285 0.0398860398860398 SULT1A; aryl sulfotransferase [EC:2.8.2.1] path:map05204 Chemical carcinogenesis - DNA adducts 125.0 10.0 3.0 3.0 0.526315789473684 H 3.0 16.0 3.0 0.526315789473684 28KEA 19.0 0.1578947368421052 0.8421052631578947 0.066701141860665 0.20865987334958 0.1376805076051225 0.141958731488915 0 0 0 0 K01016 0.0085714285714285 0.0142450142450142 SULT1E1, STE; estrone sulfotransferase [EC:2.8.2.4] path:map00140,path:map01100 Steroid hormone biosynthesis,Metabolic pathways 175.0 8.0 0.0 1.0 1.0 S 3.0 5.0 1.0 1.0 KOG1584 8.0 0.375 0.625 0.0573959235423639 0.62199219291918 0.3396940582307719 0.5645962693768161 0 0 0 0 K01023 0.0057142857142857 0.0341880341880341 assT; arylsulfate sulfotransferase [EC:2.8.2.22] 107.0 7.0 0.0 3.0 0.411764705882353 O 2.0 15.0 3.0 0.588235294117647 28MBK 17.0 0.1176470588235294 0.8823529411764706 0.117047669922186 0.10961383995635 0.113330754939268 0.0074338299658359 0 0 0 0 K01025 0.0085714285714285 0.0142450142450142 SULT1; sulfotransferase [EC:2.8.2.-] 175.0 8.0 0.0 1.0 1.0 S 3.0 5.0 1.0 1.0 KOG1584 8.0 0.375 0.625 0.0568260569939862 0.637936708659552 0.3473813828267691 0.5811106516655657 0 0 0 0 K01026 0.06 0.0598290598290598 pct; propionate CoA-transferase [EC:2.8.3.1] path:map00620,path:map00640,path:map00643,path:map01100,path:map01120 Pyruvate metabolism,Propanoate metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 461.0 56.0 0.0 1.0 1.0 I 24.0 32.0 1.0 1.0 COG4670 Acyl_CoA:acetate/3-ketoacid_CoA_transferase YdiF 56.0 0.4285714285714285 0.5714285714285714 0.004441696403036 0.0194001014113529 0.0119208989071944 0.0149584050083169 0 0 0 0 K01027 0.0 0.094017094017094 OXCT; 3-oxoacid CoA-transferase [EC:2.8.3.5] path:map00280,path:map00650,path:map01100 Valine, leucine and isoleucine degradation,Butanoate metabolism,Metabolic pathways 54.0 44.0 0.0 1.0 1.0 I 0.0 43.0 2.0 0.75 COG1788 Acyl_CoA:acetate/3-ketoacid_CoA_transferase,_alpha_subunit AtoD 43.0 0.0 1.0 0.0022199666059497 0.0395905898089065 0.0209052782074281 0.0373706232029568 0 0 0 0 K01028 0.0 0.2336182336182336 scoA; 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] path:map00280,path:map00650,path:map01100 Valine, leucine and isoleucine degradation,Butanoate metabolism,Metabolic pathways 209.0 93.0 90.0 2.0 0.96875 I 0.0 96.0 2.0 0.96875 COG1788 Acyl_CoA:acetate/3-ketoacid_CoA_transferase,_alpha_subunit AtoD 96.0 0.0 1.0 0.0046031962109845 0.168337996371412 0.0864705962911982 0.1637348001604275 0 0 0 0 K01029 0.0 0.2421652421652421 scoB; 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] path:map00280,path:map00650,path:map01100 Valine, leucine and isoleucine degradation,Butanoate metabolism,Metabolic pathways 199.0 100.0 99.0 2.0 0.99009900990099 I 0.0 101.0 1.0 1.0 COG2057 Acyl-CoA:acetate/3-ketoacid_CoA_transferase,_beta_subunit AtoA 101.0 0.0 1.0 0.007751505878745 0.170934828167957 0.089343167023351 0.1631833222892119 0 0 0 0 K01031 0.0 0.1025641025641025 pcaI; 3-oxoadipate CoA-transferase, alpha subunit [EC:2.8.3.6] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 222.0 42.0 0.0 1.0 1.0 I 0.0 42.0 1.0 1.0 COG1788 Acyl_CoA:acetate/3-ketoacid_CoA_transferase,_alpha_subunit AtoD 42.0 0.0 1.0 0.0027671443912788 0.0867213685038514 0.0447442564475651 0.0839542241125726 0 0 0 0 K01032 0.0 0.1025641025641025 pcaJ; 3-oxoadipate CoA-transferase, beta subunit [EC:2.8.3.6] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 206.0 41.0 0.0 1.0 1.0 I 0.0 41.0 1.0 1.0 COG2057 Acyl-CoA:acetate/3-ketoacid_CoA_transferase,_beta_subunit AtoA 41.0 0.0 1.0 0.0011725495696795 0.0089326805370089 0.0050526150533442 0.0077601309673293 0 0 0 0 K01034 0.0 0.1282051282051282 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] path:map00310,path:map00627,path:map00650,path:map01100,path:map01120,path:map02020 Lysine degradation,Aminobenzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 203.0 47.0 0.0 1.0 1.0 I 0.0 47.0 1.0 1.0 COG1788 Acyl_CoA:acetate/3-ketoacid_CoA_transferase,_alpha_subunit AtoD 47.0 0.0 1.0 0.145648442485251 0.695210279135339 0.4204293608102949 0.549561836650088 0 0 0 0 K01035 0.0 0.0769230769230769 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] path:map00310,path:map00627,path:map00650,path:map01100,path:map01120,path:map02020 Lysine degradation,Aminobenzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 206.0 29.0 0.0 1.0 1.0 I 0.0 29.0 2.0 0.96551724137931 COG2057 Acyl-CoA:acetate/3-ketoacid_CoA_transferase,_beta_subunit AtoA 29.0 0.0 1.0 0.0158670305421083 0.0773893723660347 0.0466282014540715 0.0615223418239264 0 0 0 0 K01039 0.1285714285714285 0.1481481481481481 gctA; glutaconate CoA-transferase, subunit A [EC:2.8.3.12] path:map00643,path:map00650,path:map01100,path:map01120 Styrene degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 170.0 125.0 0.0 1.0 1.0 I 56.0 69.0 2.0 0.992 COG1788 Acyl_CoA:acetate/3-ketoacid_CoA_transferase,_alpha_subunit AtoD 125.0 0.448 0.552 0.100858418884782 0.52499495691437 0.312926687899576 0.424136538029588 0 0 0 0 K01040 0.1257142857142857 0.1367521367521367 gctB; glutaconate CoA-transferase, subunit B [EC:2.8.3.12] path:map00643,path:map00650,path:map01100,path:map01120 Styrene degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 164.0 110.0 108.0 2.0 0.982142857142857 I 52.0 60.0 2.0 0.982142857142857 COG2057 Acyl-CoA:acetate/3-ketoacid_CoA_transferase,_beta_subunit AtoA 112.0 0.4642857142857143 0.5357142857142857 0.257803616839595 0.783431261588114 0.5206174392138545 0.5256276447485191 0 0 0 0 K01042 0.0685714285714285 0.358974358974359 selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1] path:map00450,path:map00970,path:map01100 Selenocompound metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways 204.0 84.0 37.0 3.0 0.485549132947977 E 26.0 147.0 4.0 0.942196531791908 COG1921 Seryl-tRNA(Sec)_selenium_transferase SelA 173.0 0.1502890173410404 0.8497109826589595 0.0294350401106842 0.395409170896147 0.2124221055034156 0.3659741307854628 0 0 0 0 K01045 0.0 0.0085470085470085 PON; arylesterase / paraoxonase [EC:3.1.1.2 3.1.8.1] 109.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG2374 Predicted_extracellular_nuclease 3.0 0.0 1.0 0 0 0 0 K01046 0.0085714285714285 0.1709401709401709 lip, TGL2; triacylglycerol lipase [EC:3.1.1.3] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 28.0 48.0 7.0 5.0 0.457142857142857 S 4.0 98.0 7.0 0.552380952380952 COG1075 Triacylglycerol_esterase/lipase_EstA,_alpha/beta_hydrolase_fold EstA 102.0 0.0392156862745098 0.9607843137254902 0.014613997221703 0.0264656225505876 0.0205398098861453 0.0118516253288846 0 0 0 0 K01048 0.0114285714285714 0.1794871794871795 pldB; lysophospholipase [EC:3.1.1.5] path:map00564 Glycerophospholipid metabolism 107.0 73.0 0.0 1.0 1.0 I 4.0 69.0 1.0 1.0 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 73.0 0.0547945205479452 0.9452054794520548 0.141577195899093 0.708193785240823 0.424885490569958 0.56661658934173 0 0 0 0 K01050 0.0 0.0056980056980056 BCHE; cholinesterase [EC:3.1.1.8] 504.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG2272 Carboxylesterase_type_B PnbA 3.0 0.0 1.0 0 0 0 0 K01051 0.0257142857142857 0.0883190883190883 E3.1.1.11; pectinesterase [EC:3.1.1.11] path:map00040,path:map01100,path:map02020 Pentose and glucuronate interconversions,Metabolic pathways,Two-component system 88.0 50.0 47.0 6.0 0.847457627118644 G 11.0 48.0 8.0 0.76271186440678 COG4677 Pectin_methylesterase_and_related_acyl-CoA_thioesterases PemB 59.0 0.1864406779661017 0.8135593220338984 0.461518138867352 0.0383247975297172 0.2499214681985345 0.4231933413376348 0 0 0 0 K01053 0.0228571428571428 0.2307692307692307 gnl, RGN; gluconolactonase [EC:3.1.1.17] path:map00030,path:map00053,path:map00930,path:map01100,path:map01110,path:map01120,path:map01200,path:map01220,path:map01240 Pentose phosphate pathway,Ascorbate and aldarate metabolism,Caprolactam degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Degradation of aromatic compounds,Biosynthesis of cofactors 76.0 151.0 149.0 3.0 0.980519480519481 G 8.0 146.0 3.0 0.941558441558442 COG3386 Sugar_lactone_lactonase_YvrE YvrE 154.0 0.0519480519480519 0.948051948051948 0.017829619052259 0.0706405179124934 0.0442350684823762 0.0528108988602344 0 0 0 0 K01054 0.0114285714285714 0.0 MGLL; acylglycerol lipase [EC:3.1.1.23] path:map00561,path:map01100,path:map04714,path:map04723,path:map04923 Glycerolipid metabolism,Metabolic pathways,Thermogenesis,Retrograde endocannabinoid signaling,Regulation of lipolysis in adipocytes 153.0 4.0 0.0 1.0 1.0 I 4.0 0.0 1.0 1.0 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 4.0 1.0 0.0 0.0146657834861491 0.380514596767048 0.1975901901265985 0.3658488132808989 0 0 0 0 K01055 0.06 0.1908831908831909 pcaD; 3-oxoadipate enol-lactonase [EC:3.1.1.24] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 76.0 67.0 17.0 4.0 0.536 I 22.0 103.0 6.0 0.48 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 125.0 0.176 0.824 0.0179099476022145 0.794481217995219 0.4061955827987167 0.7765712703930044 0 0 0 0 K01056 0.0028571428571428 0.98005698005698 PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] 72.0 351.0 345.0 4.0 0.975 J 1.0 359.0 5.0 0.969444444444444 COG0193 Peptidyl-tRNA_hydrolase Pth 360.0 0.0027777777777777 0.9972222222222222 0.086337771970599 0.590331432557974 0.3383346022642865 0.503993660587375 0 0 0 0 K01057 0.0371428571428571 0.4472934472934473 PGLS, pgl, devB; 6-phosphogluconolactonase [EC:3.1.1.31] path:map00030,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 95.0 187.0 186.0 2.0 0.99468085106383 G 15.0 173.0 2.0 0.99468085106383 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate_isomerase/deaminase NagB 188.0 0.0797872340425532 0.9202127659574468 0.0072654506807185 0.160330258265349 0.0837978544730337 0.1530648075846305 0 0 0 0 K01058 0.0 0.0769230769230769 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] path:map00564,path:map00565,path:map00590,path:map00591,path:map00592,path:map01100,path:map01110 Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism,Linoleic acid metabolism,alpha-Linolenic acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 152.0 24.0 20.0 2.0 0.857142857142857 M 0.0 28.0 2.0 0.821428571428571 COG2829 Outer_membrane_phospholipase_A PldA 28.0 0.0 1.0 0.0208954622274612 0.0424435470505959 0.0316695046390285 0.0215480848231347 0 0 0 0 K01060 0.0 0.0883190883190883 cah; cephalosporin-C deacetylase [EC:3.1.1.41] path:map00311,path:map01110 Penicillin and cephalosporin biosynthesis,Biosynthesis of secondary metabolites 251.0 37.0 0.0 1.0 1.0 Q 0.0 37.0 1.0 1.0 COG3458 Cephalosporin-C_deacetylase_or_related_acetyl_esterase Axe1 37.0 0.0 1.0 0.0431976829176937 0.0877731066497567 0.0654853947837252 0.0445754237320629 0 0 0 0 K01061 0.0942857142857142 0.3846153846153846 E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45] path:map00361,path:map00364,path:map00623,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Fluorobenzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments 22.0 312.0 303.0 4.0 0.96594427244582 Q 40.0 279.0 2.0 0.978328173374613 COG0412 Dienelactone_hydrolase DLH 319.0 0.1253918495297805 0.8746081504702194 0.0029068280955674 0.0942847493409604 0.0485957887182639 0.091377921245393 0 0 0 0 K01066 0.16 0.2136752136752136 aes; acetyl esterase [EC:3.1.1.-] 106.0 210.0 209.0 3.0 0.990566037735849 I 83.0 129.0 2.0 0.995283018867924 COG0657 Acetyl_esterase/lipase Aes 212.0 0.3915094339622642 0.6084905660377359 0.0024338695089185 0.0210102757950101 0.0117220726519643 0.0185764062860916 0 0 0 0 K01067 0.0171428571428571 0.1082621082621082 E3.1.2.1, ACH1; acetyl-CoA hydrolase [EC:3.1.2.1] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 357.0 55.0 0.0 1.0 1.0 C 9.0 46.0 1.0 1.0 COG0427 Propionyl_CoA:succinate_CoA_transferase ACH1 55.0 0.1636363636363636 0.8363636363636363 0.0066673839149556 0.0379749858547572 0.0223211848848563 0.0313076019398016 0 0 0 0 K01069 0.3828571428571428 0.50997150997151 gloB, gloC, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 33.0 353.0 244.0 7.0 0.721881390593047 S 234.0 254.0 5.0 0.787321063394683 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 488.0 0.4795081967213114 0.5204918032786885 0.0035057494206878 0.100160017530632 0.0518328834756599 0.0966542681099442 0 0 0 0 K01070 0.0 0.1823361823361823 frmB, ESD, fghA; S-formylglutathione hydrolase [EC:3.1.2.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 214.0 69.0 66.0 2.0 0.958333333333333 S 0.0 72.0 1.0 1.0 COG0627 S-formylglutathione_hydrolase_FrmB FrmB 72.0 0.0 1.0 0.0037025596178651 0.0113126460780257 0.0075076028479454 0.0076100864601605 0 0 0 0 K01071 0.0028571428571428 0.1566951566951566 MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21] path:map00061,path:map01100 Fatty acid biosynthesis,Metabolic pathways 55.0 37.0 13.0 2.0 0.60655737704918 I 1.0 60.0 2.0 0.60655737704918 COG3884 Acyl-ACP_thioesterase FatA 61.0 0.0163934426229508 0.9836065573770492 0.0030890315949498 0.017057257668512 0.0100731446317309 0.0139682260735621 0 0 0 0 K01073 0.0428571428571428 0.0712250712250712 E3.1.2.20; acyl-CoA hydrolase [EC:3.1.2.20] 101.0 42.0 40.0 2.0 0.954545454545455 I 17.0 27.0 4.0 0.795454545454545 COG1607 Acyl-CoA_hydrolase YciA 44.0 0.3863636363636363 0.6136363636363636 0.0065978549749933 0.187463145682231 0.0970305003286121 0.1808652907072377 0 0 0 0 K01074 0.0 0.0028490028490028 PPT; palmitoyl-protein thioesterase [EC:3.1.2.22] path:map00062,path:map01100,path:map01212,path:map04142 Fatty acid elongation,Metabolic pathways,Fatty acid metabolism,Lysosome 351.0 1.0 0.0 1.0 1.0 IO 0.0 1.0 1.0 1.0 COG1075 Triacylglycerol_esterase/lipase_EstA,_alpha/beta_hydrolase_fold EstA 1.0 0.0 1.0 0 0 0 0 K01075 0.0285714285714285 0.1282051282051282 E3.1.2.23; 4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23] path:map00130,path:map00362,path:map01100,path:map01110,path:map01120 Ubiquinone and other terpenoid-quinone biosynthesis,Benzoate degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 56.0 40.0 29.0 3.0 0.677966101694915 S 10.0 49.0 3.0 0.830508474576271 COG0824 Acyl-CoA_thioesterase_FadM FadM 59.0 0.1694915254237288 0.8305084745762712 0.0133820898845185 0.0553014898464386 0.0343417898654785 0.0419193999619201 0 0 0 0 K01077 0.0742857142857142 0.4017094017094017 E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] path:map00730,path:map00790,path:map01100,path:map01240,path:map02020 Thiamine metabolism,Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Two-component system 33.0 161.0 115.0 9.0 0.715555555555556 P 26.0 198.0 14.0 0.671111111111111 COG1785 Alkaline_phosphatase PhoA 224.0 0.1160714285714285 0.8839285714285714 0.625766832004912 0.783933103340885 0.7048499676728985 0.1581662713359729 0 1 0 1 K01079 0.6314285714285715 0.3247863247863248 serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3] path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 51.0 342.0 321.0 6.0 0.879177377892031 E 270.0 117.0 8.0 0.93573264781491 COG0560 Phosphoserine_phosphatase SerB 387.0 0.6976744186046512 0.3023255813953488 0.314638239645561 0.339827484564372 0.3272328621049665 0.025189244918811 0 0 0 0 K01081 0.0914285714285714 0.3732193732193732 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] path:map00230,path:map00240,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 50.0 195.0 161.0 7.0 0.815899581589958 F 35.0 202.0 12.0 0.809917355371901 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 237.0 0.1476793248945147 0.8523206751054853 0.0325324324247335 0.0442960839242179 0.0384142581744757 0.0117636514994843 0 0 0 0 K01082 0.0685714285714285 0.4074074074074074 cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 105.0 137.0 88.0 3.0 0.728723404255319 P 24.0 164.0 2.0 0.73936170212766 COG1218 3'-Phosphoadenosine_5'-phosphosulfate_(PAPS)_3'-phosphatase CysQ 188.0 0.1276595744680851 0.8723404255319149 0.0272687381113207 0.014051027149136 0.0206598826302283 0.0132177109621847 0 0 0 0 K01083 0.0057142857142857 0.131054131054131 E3.1.3.8; 3-phytase [EC:3.1.3.8] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 32.0 29.0 23.0 14.0 0.483333333333333 I 2.0 57.0 15.0 0.383333333333333 COG4247 3-phytase_(myo-inositol-hexaphosphate_3-phosphohydrolase) Phy 59.0 0.0338983050847457 0.9661016949152542 0.0271889471425822 0.0580648433119413 0.0426268952272617 0.030875896169359 0 0 0 0 K01085 0.0 0.0199430199430199 agp; glucose-1-phosphatase [EC:3.1.3.10] path:map00010,path:map01120 Glycolysis / Gluconeogenesis,Microbial metabolism in diverse environments 32.0 7.0 6.0 2.0 0.875 S 0.0 9.0 2.0 0.727272727272727 2DB79 9.0 0.0 1.0 0.0180982240275688 0.0443044065882638 0.0312013153079163 0.026206182560695 0 0 0 0 K01086 0.0 0.0227920227920227 fbp-SEBP; fructose-1,6-bisphosphatase I / sedoheptulose-1,7-bisphosphatase [EC:3.1.3.11 3.1.3.37] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 336.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG0158 Fructose-1,6-bisphosphatase Fbp 9.0 0.0 1.0 0.0828649648410843 0.0856713586884279 0.0842681617647561 0.0028063938473436 0 0 0 0 K01087 0.12 0.2222222222222222 otsB; trehalose 6-phosphate phosphatase [EC:3.1.3.12] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 92.0 121.0 117.0 4.0 0.9453125 G 42.0 86.0 5.0 0.703125 COG1877 Trehalose-6-phosphate_phosphatase OtsB 128.0 0.328125 0.671875 0.0367239835289056 0.060250610775551 0.0484872971522283 0.0235266272466454 0 0 0 0 K01089 0.0257142857142857 0.2735042735042735 hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 168.0 109.0 0.0 1.0 1.0 E 9.0 100.0 3.0 0.944954128440367 COG0131 Imidazoleglycerol_phosphate_dehydratase_HisB HisB2 109.0 0.0825688073394495 0.9174311926605504 0.0024481818141451 0.0053923558265616 0.0039202688203533 0.0029441740124165 0 0 0 0 K01090 0.3114285714285714 0.2507122507122507 E3.1.3.16; protein phosphatase [EC:3.1.3.16] 27.0 271.0 262.0 7.0 0.928082191780822 T 138.0 147.0 9.0 0.631399317406143 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 285.0 0.4842105263157895 0.5157894736842106 0.017246424524514 0.0510978384852365 0.0341721315048752 0.0338514139607225 0 0 0 0 K01091 0.0 0.0 gph; phosphoglycolate phosphatase [EC:3.1.3.18] path:map00630,path:map01100,path:map01110 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 705.0 665.0 10.0 0.886792452830189 S 0.0 0.0 10.0 0.853199498117942 COG0546 Phosphoglycolate_phosphatase,_HAD_superfamily Gph 0.0 0 0 0 0 K01092 0.6142857142857143 0.7407407407407407 E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] path:map00521,path:map00562,path:map01100,path:map01110,path:map04070 Streptomycin biosynthesis,Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Phosphatidylinositol signaling system 39.0 731.0 711.0 5.0 0.961842105263158 G 285.0 474.0 4.0 0.976315789473684 COG0483 Archaeal_fructose-1,6-bisphosphatase_or_related_enzyme,_inositol_monophosphatase_family SuhB 759.0 0.375494071146245 0.6245059288537549 0.169668878223323 0.23256153524223 0.2011152067327765 0.062892657018907 0 0 0 0 K01093 0.0 0.0113960113960113 appA; 4-phytase / acid phosphatase [EC:3.1.3.26 3.1.3.2] path:map00562,path:map00740,path:map01100 Inositol phosphate metabolism,Riboflavin metabolism,Metabolic pathways 402.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2DB79 4.0 0.0 1.0 0.0782958053209513 0.167745823012136 0.1230208141665436 0.0894500176911847 0 0 0 0 K01095 0.0114285714285714 0.3874643874643874 pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 99.0 142.0 0.0 1.0 1.0 I 4.0 138.0 1.0 1.0 COG1267 Phosphatidylglycerophosphatase_A PgpA 142.0 0.028169014084507 0.971830985915493 0.0023703692939521 0.0090462992557738 0.0057083342748629 0.0066759299618217 0 0 0 0 K01096 0.0057142857142857 0.0683760683760683 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 98.0 25.0 24.0 2.0 0.961538461538462 I 2.0 24.0 1.0 1.0 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 26.0 0.0769230769230769 0.9230769230769232 0.0039274591569004 0.0164142630067788 0.0101708610818396 0.0124868038498784 0 0 0 0 K01097 0.0057142857142857 0.0 NANP; N-acylneuraminate-9-phosphatase [EC:3.1.3.29] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 192.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 2.0 1.0 0.0 0 0 0 0 K01101 0.3657142857142857 0.1538461538461538 E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 149.0 192.0 190.0 2.0 0.989690721649485 G 138.0 58.0 3.0 0.979591836734694 COG0647 Ribonucleotide_monophosphatase_NagD,_HAD_superfamily NagD 196.0 0.7040816326530612 0.2959183673469387 0.877683478804881 0.248551367082004 0.5631174229434425 0.629132111722877 1 1 1 1 K01104 0.0 0.0 E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] 406.0 320.0 7.0 0.797642436149312 T 0.0 0.0 7.0 0.640471512770138 COG0394 Protein-tyrosine-phosphatase Wzb 0.0 0 0 0 0 K01113 0.0685714285714285 0.2792022792022792 phoD; alkaline phosphatase D [EC:3.1.3.1] path:map00790,path:map01100,path:map01240,path:map02020 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Two-component system 16.0 148.0 106.0 8.0 0.694835680751174 P 32.0 168.0 15.0 0.666666666666667 COG3540 Phosphodiesterase/alkaline_phosphatase_D PhoD 200.0 0.16 0.84 0.0259532514226333 0.0628720405027925 0.0444126459627129 0.0369187890801592 0 0 0 0 K01114 0.0285714285714285 0.1111111111111111 plc; phospholipase C [EC:3.1.4.3] path:map00562,path:map00564,path:map00565,path:map01100,path:map01110,path:map02024,path:map04919 Inositol phosphate metabolism,Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing,Thyroid hormone signaling pathway 78.0 62.0 49.0 4.0 0.794871794871795 M 15.0 63.0 7.0 0.782051282051282 COG3511 Phospholipase_C PlcC 78.0 0.1923076923076923 0.8076923076923077 0.0102171378398016 0.146554045017782 0.0783855914287918 0.1363369071779804 0 0 0 0 K01115 0.0028571428571428 0.0284900284900284 PLD1_2; phospholipase D1/2 [EC:3.1.4.4] path:map00564,path:map00565,path:map01100,path:map01110,path:map04014,path:map04024,path:map04071,path:map04072,path:map04144,path:map04666,path:map04724,path:map04912,path:map04928,path:map05200,path:map05208,path:map05212,path:map05231 Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Ras signaling pathway,cAMP signaling pathway,Sphingolipid signaling pathway,Phospholipase D signaling pathway,Endocytosis,Fc gamma R-mediated phagocytosis,Glutamatergic synapse,GnRH signaling pathway,Parathyroid hormone synthesis, secretion and action,Pathways in cancer,Chemical carcinogenesis - reactive oxygen species,Pancreatic cancer,Choline metabolism in cancer 278.0 12.0 0.0 1.0 1.0 I 1.0 11.0 2.0 0.916666666666667 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin_synthase Cls 12.0 0.0833333333333333 0.9166666666666666 0.0063178379507544 0.0414044607030426 0.0238611493268985 0.0350866227522882 0 0 0 0 K01117 0.0028571428571428 0.0085470085470085 sph; sphingomyelin phosphodiesterase [EC:3.1.4.12] path:map00600,path:map01100 Sphingolipid metabolism,Metabolic pathways 245.0 3.0 2.0 2.0 0.75 S 1.0 3.0 1.0 1.0 COG3568 Metal-dependent_hydrolase,_endonuclease/exonuclease/phosphatase_family ElsH 4.0 0.25 0.75 0.0799854835223013 0.173914456074965 0.1269499697986331 0.0939289725526637 0 0 0 0 K01118 0.0028571428571428 0.2222222222222222 acpD, azoR; FMN-dependent NADH-azoreductase [EC:1.7.1.17] 115.0 68.0 24.0 2.0 0.607142857142857 I 1.0 111.0 1.0 1.0 COG1182 FMN-dependent_NADH-azoreductase AzoR 112.0 0.0089285714285714 0.9910714285714286 0.0039174258675013 0.0300353254836896 0.0169763756755954 0.0261178996161883 0 0 0 0 K01119 0.1 0.2849002849002849 cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase [EC:3.1.4.16 3.1.3.6] path:map00230,path:map00240,path:map01100 Purine metabolism,Pyrimidine metabolism,Metabolic pathways 93.0 151.0 144.0 9.0 0.853107344632768 F 46.0 131.0 14.0 0.853107344632768 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 177.0 0.2598870056497175 0.7401129943502824 0.215991028766945 0.663670710553719 0.4398308696603319 0.447679681786774 0 0 0 0 K01120 0.0057142857142857 0.0769230769230769 cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 103.0 18.0 1.0 3.0 0.486486486486487 T 2.0 35.0 8.0 0.405405405405405 COG1234 Ribonuclease_BN,_tRNA_processing_enzyme ElaC 37.0 0.054054054054054 0.945945945945946 0.0075473065168037 0.0647181406576676 0.0361327235872356 0.0571708341408638 0 0 0 0 K01121 0.0 0.0028490028490028 CNP; 2',3'-cyclic-nucleotide 3'-phosphodiesterase [EC:3.1.4.37] 726.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 1.0 0.0 1.0 0 0 0 0 K01124 0.0142857142857142 0.0 GDPD2; glycerophosphoinositol inositolphosphodiesterase [EC:3.1.4.43] 504.0 5.0 0.0 1.0 1.0 C 5.0 0.0 1.0 1.0 COG0584 Glycerophosphoryl_diester_phosphodiesterase UgpQ 5.0 1.0 0.0 0.611685153570593 0.905439436952799 0.758562295261696 0.293754283382206 0 0 0 1 K01126 0.3171428571428571 0.6438746438746439 E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] path:map00564 Glycerophospholipid metabolism 18.0 609.0 600.0 12.0 0.944186046511628 C 176.0 456.0 10.0 0.948837209302326 COG0584 Glycerophosphoryl_diester_phosphodiesterase UgpQ 632.0 0.2784810126582278 0.7215189873417721 0.0458791944348736 0.352787893530198 0.1993335439825358 0.3069086990953244 0 0 0 0 K01127 0.0 0.0056980056980056 GPLD1; glycosylphosphatidylinositol phospholipase D [EC:3.1.4.50] path:map00563,path:map01100 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,Metabolic pathways 231.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 2.0 0.5 COG2133 Glucose/arabinose_dehydrogenase,_beta-propeller_fold YliI 2.0 0.0 1.0 0 0 0 0 K01128 0.0 0.0113960113960113 SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-] 285.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG1409 3',5'-cyclic_AMP_phosphodiesterase_CpdA CpdA 6.0 0.0 1.0 0.0099673345966622 0.0212033329447159 0.015585333770689 0.0112359983480537 0 0 0 0 K01129 0.06 0.6210826210826211 dgt; dGTPase [EC:3.1.5.1] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 155.0 272.0 0.0 1.0 1.0 F 23.0 249.0 1.0 1.0 COG0232 dGTP_triphosphohydrolase Dgt 272.0 0.0845588235294117 0.9154411764705882 0.325190735108216 0.2834200127145 0.304305373911358 0.0417707223937159 0 0 0 0 K01130 0.1114285714285714 0.188034188034188 E3.1.6.1; arylsulfatase [EC:3.1.6.1] path:map00600,path:map01100 Sphingolipid metabolism,Metabolic pathways 156.0 255.0 0.0 1.0 1.0 P 69.0 185.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 254.0 0.2716535433070866 0.7283464566929134 0.0070485247744692 0.0254382236674821 0.0162433742209756 0.0183896988930129 0 0 0 0 K01132 0.0 0.0142450142450142 GALNS; N-acetylgalactosamine-6-sulfatase [EC:3.1.6.4] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 404.0 7.0 0.0 1.0 1.0 P 0.0 7.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 7.0 0.0 1.0 0.0194810141278785 0.0424997307445731 0.0309903724362258 0.0230187166166945 0 0 0 0 K01133 0.0742857142857142 0.1111111111111111 betC; choline-sulfatase [EC:3.1.6.6] 148.0 111.0 0.0 1.0 1.0 P 29.0 81.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 110.0 0.2636363636363636 0.7363636363636363 0.0008625087391129 0.0015004465573975 0.0011814776482552 0.0006379378182846 0 0 0 0 K01134 0.0085714285714285 0.0256410256410256 ARSA; arylsulfatase A [EC:3.1.6.8] path:map00600,path:map01100,path:map04142 Sphingolipid metabolism,Metabolic pathways,Lysosome 283.0 27.0 0.0 1.0 1.0 P 3.0 24.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 27.0 0.1111111111111111 0.8888888888888888 0.0103885220467511 0.026190732993997 0.018289627520374 0.0158022109472459 0 0 0 0 K01135 0.0 0.0142450142450142 ARSB; arylsulfatase B [EC:3.1.6.12] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 396.0 9.0 0.0 1.0 1.0 P 0.0 9.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 9.0 0.0 1.0 0.0194524992638844 0.0462142741995488 0.0328333867317165 0.0267617749356644 0 0 0 0 K01136 0.0 0.0227920227920227 IDS; iduronate 2-sulfatase [EC:3.1.6.13] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 317.0 14.0 10.0 2.0 0.777777777777778 P 0.0 18.0 2.0 0.777777777777778 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 18.0 0.0 1.0 0.0055007824899722 0.0105953116213264 0.0080480470556493 0.0050945291313542 0 0 0 0 K01137 0.0 0.0427350427350427 GNS; N-acetylglucosamine-6-sulfatase [EC:3.1.6.14] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 333.0 20.0 19.0 2.0 0.952380952380952 P 0.0 21.0 2.0 0.857142857142857 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 21.0 0.0 1.0 0.0318240822232903 0.0844705342562714 0.0581473082397808 0.0526464520329811 0 0 0 0 K01138 0.1228571428571428 0.1424501424501424 K01138; uncharacterized sulfatase [EC:3.1.6.-] 88.0 93.0 43.0 6.0 0.53448275862069 P 73.0 101.0 7.0 0.540229885057471 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 174.0 0.4195402298850574 0.5804597701149425 0.0037004830712036 0.0064034704100803 0.0050519767406419 0.0027029873388767 0 0 0 0 K01139 0.0342857142857142 0.4245014245014245 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 186.0 185.0 184.0 3.0 0.989304812834225 KT 14.0 169.0 1.0 1.0 COG0317 (p)ppGpp_synthase/hydrolase,_HD_superfamily SpoT 183.0 0.0765027322404371 0.9234972677595628 0.0611459655437969 0.0317229321685462 0.0464344488561715 0.0294230333752507 0 0 0 0 K01141 0.0 0.0797720797720797 sbcB, exoI; exodeoxyribonuclease I [EC:3.1.11.1] path:map03430 Mismatch repair 368.0 28.0 0.0 1.0 1.0 L 0.0 28.0 1.0 1.0 COG2925 Exonuclease_I_(degrades_ssDNA) SbcB 28.0 0.0 1.0 0.0171328860485455 0.515532052019463 0.2663324690340042 0.4983991659709174 0 0 0 0 K01142 0.2428571428571428 0.7207977207977208 E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] path:map03410 Base excision repair 82.0 427.0 425.0 4.0 0.988425925925926 L 89.0 343.0 4.0 0.935185185185185 COG0708 Exonuclease_III XthA 432.0 0.2060185185185185 0.7939814814814815 0.0082372264772028 0.0326750540777024 0.0204561402774526 0.0244378276004996 0 0 0 0 K01143 0.0 0.0028490028490028 exo; Enterobacteriaceae phage exonuclease [EC:3.1.11.3] 87.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 28MEG 1.0 0.0 1.0 0 0 0 0 K01144 0.0 0.1282051282051282 181.0 53.0 0.0 1.0 1.0 L 0.0 52.0 4.0 0.792452830188679 COG0507 ATPase/5-3_helicase_helicase_subunit_RecD_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecD 52.0 0.0 1.0 0.0300426417343669 0.139531422030218 0.0847870318822924 0.1094887802958511 0 0 0 0 K01146 0.0 0.0113960113960113 xni; protein Xni 249.0 4.0 0.0 1.0 1.0 L 0.0 4.0 1.0 1.0 COG0258 5'-3'_exonuclease_Xni/ExoIX_(flap_endonuclease) ExoIX 4.0 0.0 1.0 7.54360932027932e-12 6.86564902015881e-08 3.433201690545419e-08 6.864894659226784e-08 0 0 0 0 K01147 0.0285714285714285 0.1766381766381766 rnb; exoribonuclease II [EC:3.1.13.1] 240.0 66.0 58.0 2.0 0.891891891891892 K 11.0 63.0 2.0 0.905405405405405 COG0557 Exoribonuclease_R VacB 74.0 0.1486486486486486 0.8513513513513513 0.016540890436883 0.0158342494475487 0.0161875699422158 0.0007066409893343 0 0 0 0 K01150 0.0 0.0455840455840455 endA; deoxyribonuclease I [EC:3.1.21.1] 199.0 23.0 0.0 1.0 1.0 L 0.0 23.0 1.0 1.0 COG2356 Endonuclease_I EndA 23.0 0.0 1.0 0.012779351311965 0.0249650256513507 0.0188721884816578 0.0121856743393857 0 0 0 0 K01151 0.8485714285714285 0.4643874643874643 nfo; deoxyribonuclease IV [EC:3.1.21.2] path:map03410 Base excision repair 36.0 406.0 275.0 2.0 0.756052141527002 L 357.0 178.0 2.0 0.951582867783985 COG0648 Endonuclease_IV Nfo 535.0 0.6672897196261682 0.3327102803738317 0.0895885093072778 0.0959174293963993 0.0927529693518385 0.0063289200891215 0 0 0 0 K01152 0.0 0.0056980056980056 isftu1; isftu1 transposase 76.0 5.0 0.0 1.0 1.0 L 0.0 5.0 2.0 0.8 COG3335 Transposase 5.0 0.0 1.0 3.292293564689e-12 6.1682458514380496e-12 4.730269708063525e-12 2.8759522867490494e-12 0 0 0 0 K01153 0.0 0.0 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] 359.0 137.0 11.0 0.554868624420402 L 0.0 0.0 19.0 0.661514683153014 COG0610 Type_I_site-specific_restriction-modification_system,_R_(restriction)_subunit_and_related_helicases_... 0.0 0 0 0 0 K01154 0.0 0.0 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] 379.0 200.0 3.0 0.666080843585237 V 0.0 0.0 9.0 0.942105263157895 COG0732 Restriction_endonuclease_S_subunit HsdS 0.0 0 0 0 0 K01155 0.0685714285714285 0.1937321937321937 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] 10.0 90.0 74.0 5.0 0.789473684210526 L 26.0 79.0 24.0 0.204918032786885 arCOG06575 105.0 0.2476190476190476 0.7523809523809524 0.428173500783692 0.834119530375156 0.631146515579424 0.405946029591464 0 0 0 0 K01156 0.0 0.0 res; type III restriction enzyme [EC:3.1.21.5] 129.0 65.0 5.0 0.511904761904762 L 0.0 0.0 8.0 0.432539682539683 COG1061 Superfamily_II_DNA_or_RNA_helicase SSL2 0.0 0 0 0 0 K01159 0.0257142857142857 0.8888888888888888 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] path:map03440 Homologous recombination 84.0 325.0 0.0 1.0 1.0 L 10.0 317.0 3.0 0.99388379204893 COG0817 Holliday_junction_resolvasome_RuvABC_endonuclease_subunit_RuvC RuvC 327.0 0.0305810397553516 0.9694189602446484 0.303487794788006 0.901274040041037 0.6023809174145215 0.5977862452530309 0 0 0 0 K01160 0.0028571428571428 0.037037037037037 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10] 97.0 14.0 0.0 1.0 1.0 L 1.0 13.0 1.0 1.0 COG4570 Holliday_junction_resolvase_RusA_(prophage-encoded_endonuclease) RusA 14.0 0.0714285714285714 0.9285714285714286 0.0656478117345125 0.0668229846970051 0.0662353982157588 0.0011751729624925 0 0 0 0 K01161 0.0114285714285714 0.0 E3.1.25.1; deoxyribonuclease (pyrimidine dimer) [EC:3.1.25.1] 138.0 4.0 0.0 1.0 1.0 L 4.0 0.0 1.0 1.0 2AMM7 4.0 1.0 0.0 0.187229751467792 0.303403085947018 0.245316418707405 0.1161733344792259 0 0 0 0 K01163 0.0571428571428571 0.1396011396011396 K01163; uncharacterized protein 134.0 73.0 68.0 2.0 0.935897435897436 S 20.0 57.0 4.0 0.871794871794872 COG4866 Uncharacterized_protein,_contains_DUF2156_domain 77.0 0.2597402597402597 0.7402597402597403 0.0215856528656511 0.857541745449107 0.439563699157379 0.8359560925834559 0 0 0 0 K01166 0.0 0.074074074074074 RNASET2; ribonuclease T2 [EC:4.6.1.19] 119.0 26.0 0.0 1.0 1.0 J 0.0 26.0 1.0 1.0 COG3719 Ribonuclease_I RnaI 26.0 0.0 1.0 0.0548015472256937 0.0697836226244229 0.0622925849250583 0.0149820753987292 0 0 0 0 K01167 0.0 0.0455840455840455 rnaSA; ribonuclease T1 [EC:4.6.1.24] 110.0 18.0 0.0 1.0 1.0 F 0.0 18.0 2.0 0.944444444444444 COG4290 Guanyl-specific_ribonuclease_Sa 18.0 0.0 1.0 0.0186480993035988 0.0781751821711361 0.0484116407373674 0.0595270828675373 0 0 0 0 K01169 0.0 0.037037037037037 rna; ribonuclease I (enterobacter ribonuclease) [EC:4.6.1.21] 190.0 13.0 0.0 1.0 1.0 J 0.0 13.0 1.0 1.0 COG3719 Ribonuclease_I RnaI 13.0 0.0 1.0 0.0064814948626356 0.006768142538986 0.0066248187008108 0.0002866476763504 0 0 0 0 K01170 0.92 0.0 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16] 53.0 305.0 206.0 2.0 0.754950495049505 J 404.0 0.0 1.0 1.0 COG1676 tRNA_splicing_endonuclease_subunit_SEN34 SEN2 404.0 1.0 0.0 0.859705220534296 0.631832014521289 0.7457686175277924 0.2278732060130069 0 0 1 1 K01173 0.0171428571428571 0.1566951566951566 ENDOG; endonuclease G, mitochondrial path:map04210 Apoptosis 53.0 63.0 55.0 8.0 0.67741935483871 F 6.0 86.0 6.0 0.817204301075269 COG1864 DNA/RNA_endonuclease_G,_NUC1 NUC1 92.0 0.0652173913043478 0.9347826086956522 0.034116342916218 0.0760611083472114 0.0550887256317147 0.0419447654309934 0 0 0 0 K01174 0.2685714285714285 0.2877492877492877 nuc; micrococcal nuclease [EC:3.1.31.1] 10.0 257.0 254.0 4.0 0.969811320754717 L 117.0 136.0 9.0 0.89811320754717 COG1525 Endonuclease_YncB,_thermonuclease_family YncB 253.0 0.4624505928853755 0.5375494071146245 0.0749313857707028 0.545419494550156 0.3101754401604294 0.4704881087794532 0 0 0 0 K01175 0.0 0.0427350427350427 ybfF; esterase [EC:3.1.-.-] 231.0 13.0 11.0 2.0 0.866666666666667 S 0.0 15.0 3.0 0.8 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 15.0 0.0 1.0 0.0077337106988205 0.014034651613548 0.0108841811561842 0.0063009409147274 0 0 0 0 K01176 0.0628571428571428 0.3789173789173789 AMY, amyA, malS; alpha-amylase [EC:3.2.1.1] path:map00500,path:map01100,path:map01110,path:map04970,path:map04972,path:map04973 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Salivary secretion,Pancreatic secretion,Carbohydrate digestion and absorption 33.0 231.0 218.0 7.0 0.888461538461538 G 29.0 226.0 13.0 0.734615384615385 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 255.0 0.1137254901960784 0.8862745098039215 0.0491673657383584 0.597976706151787 0.3235720359450727 0.5488093404134285 0 0 0 0 K01178 0.1057142857142857 0.150997150997151 SGA1; glucoamylase [EC:3.2.1.3] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 93.0 107.0 91.0 2.0 0.869918699186992 G 55.0 68.0 4.0 0.796747967479675 COG3387 Glucoamylase_(glucan-1,4-alpha-glucosidase),_GH15_family SGA1 123.0 0.4471544715447154 0.5528455284552846 0.0194294094344958 0.41803884979969 0.2187341296170929 0.3986094403651942 0 0 0 0 K01179 0.0 0.0 E3.2.1.4; endoglucanase [EC:3.2.1.4] path:map00500,path:map01100,path:map02020 Starch and sucrose metabolism,Metabolic pathways,Two-component system 442.0 363.0 19.0 0.682098765432099 G 0.0 0.0 63.0 0.316436251920123 COG2730 Aryl-phospho-beta-D-glucosidase_BglC,_GH1_family BglC 0.0 0 0 0 0 K01181 0.0 0.0 E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8] 163.0 146.0 13.0 0.758139534883721 G 0.0 0.0 29.0 0.488372093023256 COG3693 Endo-1,4-beta-xylanase,_GH35_family XynA 0.0 0 0 0 0 K01182 0.0657142857142857 0.1253561253561253 IMA, malL; oligo-1,6-glucosidase [EC:3.2.1.10] path:map00052,path:map00500,path:map01100 Galactose metabolism,Starch and sucrose metabolism,Metabolic pathways 386.0 80.0 0.0 1.0 1.0 G 26.0 54.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 80.0 0.325 0.675 0.0193435874586893 0.0488465988934372 0.0340950931760632 0.0295030114347478 0 0 0 0 K01183 0.0 0.0 E3.2.1.14; chitinase [EC:3.2.1.14] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 132.0 76.0 9.0 0.591928251121076 G 0.0 0.0 28.0 0.328888888888889 COG3325 Chitinase,_GH18_family ChiA 0.0 0 0 0 0 K01184 0.0 0.0227920227920227 E3.2.1.15; polygalacturonase [EC:3.2.1.15] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 236.0 14.0 13.0 2.0 0.933333333333333 M 0.0 15.0 4.0 0.733333333333333 COG5434 Polygalacturonase Pgu1 15.0 0.0 1.0 0.0097763721672592 0.0191965322906844 0.0144864522289718 0.0094201601234252 0 0 0 0 K01185 0.0057142857142857 0.1766381766381766 E3.2.1.17; lysozyme [EC:3.2.1.17] 30.0 37.0 7.0 6.0 0.393617021276596 G 2.0 90.0 14.0 0.521276595744681 COG3772 Phage-related_lysozyme_(muramidase),_GH24_family RrrD 92.0 0.0217391304347826 0.9782608695652174 0.0068885915009075 0.0877071165649889 0.0472978540329482 0.0808185250640814 0 0 0 0 K01186 0.0 0.0 NEU1; sialidase-1 [EC:3.2.1.18] path:map00511,path:map00600,path:map01100,path:map04142 Other glycan degradation,Sphingolipid metabolism,Metabolic pathways,Lysosome 79.0 60.0 10.0 0.576642335766423 G 0.0 0.0 20.0 0.481751824817518 COG4409 Neuraminidase_(sialidase)_NanH,_contains_C-terminal_autotransporter_domain NanH 0.0 0 0 0 0 K01187 0.12 0.4358974358974359 malZ; alpha-glucosidase [EC:3.2.1.20] path:map00052,path:map00500,path:map01100,path:map01110 Galactose metabolism,Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 25.0 334.0 323.0 5.0 0.930362116991644 G 54.0 297.0 11.0 0.465181058495822 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 351.0 0.1538461538461538 0.8461538461538461 0.0455316738542929 0.137368866562931 0.0914502702086119 0.0918371927086381 0 0 0 0 K01190 0.1342857142857142 0.2507122507122507 lacZ; beta-galactosidase [EC:3.2.1.23] path:map00052,path:map00511,path:map00600,path:map01100 Galactose metabolism,Other glycan degradation,Sphingolipid metabolism,Metabolic pathways 29.0 336.0 334.0 6.0 0.979591836734694 G 64.0 269.0 14.0 0.728862973760933 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 333.0 0.1921921921921922 0.8078078078078078 0.035836571480182 0.041249069620419 0.0385428205503005 0.0054124981402369 0 0 0 0 K01191 0.1142857142857142 0.2136752136752136 MAN2C1; alpha-mannosidase [EC:3.2.1.24] path:map00511 Other glycan degradation 137.0 178.0 0.0 1.0 1.0 G 53.0 123.0 1.0 1.0 COG0383 Alpha-mannosidase MngB 176.0 0.3011363636363636 0.6988636363636364 0.785502804641663 0.943409374577389 0.864456089609526 0.157906569935726 1 1 1 1 K01192 0.0685714285714285 0.1367521367521367 E3.2.1.25, MANBA, manB; beta-mannosidase [EC:3.2.1.25] path:map00511,path:map04142 Other glycan degradation,Lysosome 221.0 108.0 0.0 1.0 1.0 G 33.0 75.0 1.0 1.0 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 108.0 0.3055555555555556 0.6944444444444444 0.420404457653094 0.579061635206176 0.499733046429635 0.158657177553082 0 0 0 0 K01193 0.0428571428571428 0.1908831908831909 INV, sacA; beta-fructofuranosidase [EC:3.2.1.26] path:map00052,path:map00500,path:map01100,path:map01110 Galactose metabolism,Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 50.0 126.0 125.0 2.0 0.992125984251968 G 17.0 103.0 5.0 0.850393700787402 COG1621 Sucrose-6-phosphate_hydrolase_SacC,_GH32_family SacC 120.0 0.1416666666666666 0.8583333333333333 0.0892254793386913 0.294481989702622 0.1918537345206566 0.2052565103639307 0 0 0 0 K01194 0.0514285714285714 0.094017094017094 TREH, treA, treF; alpha,alpha-trehalase [EC:3.2.1.28] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 156.0 63.0 59.0 4.0 0.9 G 23.0 38.0 6.0 0.542857142857143 COG1626 Neutral_trehalase TreA 61.0 0.3770491803278688 0.6229508196721312 0.0354355420906707 0.835592890988705 0.4355142165396878 0.8001573488980344 0 0 0 0 K01195 0.0485714285714285 0.1054131054131054 uidA, GUSB; beta-glucuronidase [EC:3.2.1.31] path:map00040,path:map00053,path:map00531,path:map00860,path:map00944,path:map00983,path:map01100,path:map01110,path:map01240,path:map04142 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Glycosaminoglycan degradation,Porphyrin metabolism,Flavone and flavonol biosynthesis,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Lysosome 180.0 74.0 70.0 2.0 0.948717948717949 G 22.0 56.0 5.0 0.923076923076923 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 78.0 0.282051282051282 0.717948717948718 0.713791478552383 0.233963697805874 0.4738775881791285 0.479827780746509 0 1 0 1 K01197 0.0085714285714285 0.0883190883190883 hya; hyaluronoglucosaminidase [EC:3.2.1.35] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 24.0 21.0 11.0 7.0 0.51219512195122 G 3.0 38.0 8.0 0.463414634146342 COG3525 N-acetyl-beta-hexosaminidase Chb 41.0 0.073170731707317 0.926829268292683 0.0480672964930647 0.109775320031628 0.0789213082623463 0.0617080235385633 0 0 0 0 K01198 0.0114285714285714 0.150997150997151 xynB; xylan 1,4-beta-xylosidase [EC:3.2.1.37] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 86.0 100.0 98.0 3.0 0.970873786407767 G 7.0 96.0 6.0 0.563106796116505 COG3507 Beta-xylosidase XynB2 103.0 0.0679611650485436 0.9320388349514565 0.0606061229713216 0.0403047356260604 0.050455429298691 0.0203013873452612 0 0 0 0 K01200 0.0057142857142857 0.1538461538461538 pulA; pullulanase [EC:3.2.1.41] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 269.0 72.0 70.0 4.0 0.947368421052632 G 2.0 74.0 4.0 0.828947368421053 COG1523 Pullulanase/glycogen_debranching_enzyme PulA 76.0 0.0263157894736842 0.9736842105263158 0.0262350704755635 0.904045881605523 0.4651404760405432 0.8778108111299595 0 0 0 0 K01201 0.0028571428571428 0.1025641025641025 GBA, srfJ; glucosylceramidase [EC:3.2.1.45] path:map00511,path:map00600,path:map01100,path:map04142 Other glycan degradation,Sphingolipid metabolism,Metabolic pathways,Lysosome 218.0 28.0 13.0 4.0 0.538461538461538 G 1.0 51.0 11.0 0.653846153846154 COG5520 O-Glycosyl_hydrolase XynC 52.0 0.0192307692307692 0.9807692307692308 0.0223747012278661 0.22925673090292 0.125815716065393 0.2068820296750539 0 0 0 0 K01202 0.0 0.0142450142450142 GALC; galactosylceramidase [EC:3.2.1.46] path:map00600,path:map01100,path:map04142 Sphingolipid metabolism,Metabolic pathways,Lysosome 597.0 4.0 1.0 2.0 0.571428571428571 G 0.0 7.0 2.0 0.714285714285714 COG1874 Beta-galactosidase_GanA GanA 7.0 0.0 1.0 0.0424792649601078 0.0893106725453742 0.065894968752741 0.0468314075852663 0 0 0 0 K01205 0.0 0.0427350427350427 NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 376.0 18.0 16.0 3.0 0.857142857142857 G 0.0 21.0 4.0 0.714285714285714 COG3669 Alpha-L-fucosidase AfuC 21.0 0.0 1.0 0.0283795203708274 0.0504061269431019 0.0393928236569646 0.0220266065722745 0 0 0 0 K01206 0.0314285714285714 0.1823361823361823 FUCA; alpha-L-fucosidase [EC:3.2.1.51] path:map00511,path:map04142 Other glycan degradation,Lysosome 110.0 216.0 210.0 3.0 0.968609865470852 G 16.0 206.0 14.0 0.825112107623318 COG3669 Alpha-L-fucosidase AfuC 222.0 0.072072072072072 0.927927927927928 0.0478501603291113 0.0559007804458389 0.0518754703874751 0.0080506201167275 0 0 0 0 K01207 0.0285714285714285 0.5868945868945868 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52] path:map00520,path:map00531,path:map01100,path:map01501 Amino sugar and nucleotide sugar metabolism,Glycosaminoglycan degradation,Metabolic pathways,beta-Lactam resistance 42.0 275.0 264.0 9.0 0.887096774193548 G 10.0 298.0 9.0 0.912903225806452 COG1472 Periplasmic_beta-glucosidase_and_related_glycosidases BglX 308.0 0.0324675324675324 0.9675324675324676 0.0002099364235069 0.0182286236607639 0.0092192800421354 0.018018687237257 0 0 0 0 K01208 0.08 0.2136752136752136 cd, ma, nplT; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 189.0 136.0 135.0 2.0 0.992700729927007 G 34.0 103.0 2.0 0.956204379562044 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 137.0 0.2481751824817518 0.7518248175182481 0.329703886620211 0.822246618656497 0.5759752526383539 0.4925427320362859 0 0 0 0 K01209 0.0371428571428571 0.1851851851851851 abfA; alpha-L-arabinofuranosidase [EC:3.2.1.55] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 38.0 186.0 183.0 2.0 0.984126984126984 G 30.0 157.0 6.0 0.708994708994709 COG3534 Alpha-L-arabinofuranosidase AbfA 187.0 0.160427807486631 0.839572192513369 0.0480215820964799 0.0493151793267816 0.0486683807116307 0.0012935972303017 0 0 0 0 K01210 0.0028571428571428 0.0341880341880341 E3.2.1.58; glucan 1,3-beta-glucosidase [EC:3.2.1.58] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 131.0 10.0 6.0 2.0 0.714285714285714 G 1.0 13.0 3.0 0.357142857142857 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 14.0 0.0714285714285714 0.9285714285714286 0.061008284904804 0.129162232335997 0.0950852586204005 0.0681539474311929 0 0 0 0 K01212 0.0085714285714285 0.0455840455840455 sacC, levB; levanase [EC:3.2.1.65] path:map00500 Starch and sucrose metabolism 76.0 15.0 8.0 3.0 0.6 G 3.0 22.0 4.0 0.6 COG1621 Sucrose-6-phosphate_hydrolase_SacC,_GH32_family SacC 25.0 0.12 0.88 0.0138688555645411 0.031515266223048 0.0226920608937945 0.0176464106585068 0 0 0 0 K01213 0.0028571428571428 0.0085470085470085 E3.2.1.67; galacturan 1,4-alpha-galacturonidase [EC:3.2.1.67] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 148.0 2.0 1.0 3.0 0.5 G 1.0 3.0 2.0 0.75 COG5434 Polygalacturonase Pgu1 4.0 0.25 0.75 0.120291928625466 0.195444165039991 0.1578680468327285 0.075152236414525 0 0 0 0 K01214 0.0428571428571428 0.3304843304843304 ISA, treX; isoamylase [EC:3.2.1.68] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 411.0 193.0 192.0 2.0 0.994845360824742 G 15.0 179.0 3.0 0.989690721649485 COG1523 Pullulanase/glycogen_debranching_enzyme PulA 194.0 0.0773195876288659 0.922680412371134 0.0554612962848219 0.749872232622187 0.4026667644535044 0.6944109363373652 0 0 0 0 K01215 0.0 0.0227920227920227 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70] 311.0 11.0 0.0 1.0 1.0 G 0.0 11.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 11.0 0.0 1.0 0.0300996591120006 0.226365390900918 0.1282325250064593 0.1962657317889174 0 0 0 0 K01216 0.0057142857142857 0.0313390313390313 bglS; licheninase [EC:3.2.1.73] 122.0 13.0 12.0 3.0 0.866666666666667 G 2.0 13.0 1.0 1.0 COG2273 Beta-glucanase,_GH16_family BglS 15.0 0.1333333333333333 0.8666666666666667 0.084977803834494 0.164516918825974 0.124747361330234 0.0795391149914799 0 0 0 0 K01218 0.0 0.0 gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] path:map00051,path:map01100,path:map02024 Fructose and mannose metabolism,Metabolic pathways,Quorum sensing 87.0 65.0 8.0 0.669230769230769 G 0.0 0.0 30.0 0.361538461538462 COG4124 Beta-mannanase ManB2 0.0 0 0 0 0 K01219 0.0 0.0541310541310541 E3.2.1.81; beta-agarase [EC:3.2.1.81] 70.0 24.0 23.0 3.0 0.923076923076923 G 0.0 26.0 6.0 0.576923076923077 COG1874 Beta-galactosidase_GanA GanA 26.0 0.0 1.0 0.0081547525819228 0.463803152009868 0.2359789522958953 0.4556483994279452 0 0 0 0 K01220 0.0 0.0199430199430199 E3.2.1.85, lacG; 6-phospho-beta-galactosidase [EC:3.2.1.85] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 466.0 8.0 0.0 1.0 1.0 G 0.0 8.0 1.0 1.0 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase BglB 8.0 0.0 1.0 0.107640396200595 0.489899936321336 0.2987701662609655 0.382259540120741 0 0 0 0 K01222 0.0142857142857142 0.1367521367521367 E3.2.1.86A, celF; 6-phospho-beta-glucosidase [EC:3.2.1.86] path:map00010,path:map00500 Glycolysis / Gluconeogenesis,Starch and sucrose metabolism 282.0 89.0 0.0 1.0 1.0 G 10.0 79.0 1.0 1.0 COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase,_family_4_of_glycosyl_hydrolase CelF 89.0 0.1123595505617977 0.8876404494382022 0.478557850658246 0.423520667180266 0.451039258919256 0.05503718347798 0 0 0 0 K01223 0.0 0.0 E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86] path:map00010,path:map00500 Glycolysis / Gluconeogenesis,Starch and sucrose metabolism 142.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.992957746478873 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase BglB 0.0 0 0 0 0 K01224 0.0057142857142857 0.1111111111111111 E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89] 95.0 55.0 51.0 4.0 0.859375 G 2.0 62.0 11.0 0.671875 COG3867 Arabinogalactan_endo-1,4-beta-galactosidase GanB 64.0 0.03125 0.96875 0.246116064492646 0.0192782341906681 0.132697149341657 0.2268378303019779 0 0 0 0 K01226 0.0028571428571428 0.0541310541310541 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 402.0 29.0 28.0 2.0 0.966666666666667 G 1.0 24.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 25.0 0.04 0.96 0.0238714203345983 0.245849398968661 0.1348604096516296 0.2219779786340627 0 0 0 0 K01227 0.0 0.074074074074074 ENGASE; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96] path:map00511 Other glycan degradation 18.0 12.0 1.0 7.0 0.363636363636364 S 0.0 30.0 13.0 0.303030303030303 COG3807 SH3-like_domain SH3 30.0 0.0 1.0 0.0128224295140119 0.0435226360615959 0.0281725327878039 0.030700206547584 0 0 0 0 K01230 0.0057142857142857 0.0 MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] path:map00510,path:map00513,path:map01100,path:map04141 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways,Protein processing in endoplasmic reticulum 55.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 2DBJC 2.0 1.0 0.0 0 0 0 0 K01231 0.0 0.0028490028490028 MAN2; alpha-mannosidase II [EC:3.2.1.114] path:map00510,path:map00513,path:map01100 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways 791.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 1.0 0.0 1.0 0 0 0 0 K01232 0.0 0.0341880341880341 glvA; maltose-6'-phosphate glucosidase [EC:3.2.1.122] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 430.0 21.0 0.0 1.0 1.0 G 0.0 21.0 1.0 1.0 COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase,_family_4_of_glycosyl_hydrolase CelF 21.0 0.0 1.0 0.0464361735781008 0.212503003154181 0.1294695883661409 0.1660668295760802 0 0 0 0 K01233 0.0 0.0199430199430199 csn; chitosanase [EC:3.2.1.132] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 151.0 11.0 10.0 2.0 0.916666666666667 M 0.0 12.0 5.0 0.666666666666667 COG3409 Peptidoglycan-binding_(PGRP)_domain_of_peptidoglycan_hydrolases PGRP 12.0 0.0 1.0 0.0146105097317537 0.0242459883546748 0.0194282490432142 0.0096354786229211 0 0 0 0 K01235 0.0171428571428571 0.0569800569800569 aguA; alpha-glucuronidase [EC:3.2.1.139] 571.0 27.0 0.0 1.0 1.0 G 6.0 21.0 1.0 1.0 COG3661 Alpha-glucuronidase AguA2 27.0 0.2222222222222222 0.7777777777777778 0.833556088756248 0.485083690373654 0.659319889564951 0.348472398382594 1 1 1 1 K01236 0.04 0.1908831908831909 treZ, glgZ; maltooligosyltrehalose trehalohydrolase [EC:3.2.1.141] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 348.0 93.0 0.0 1.0 1.0 G 15.0 78.0 1.0 1.0 COG0296 1,4-alpha-glucan_branching_enzyme GlgB 93.0 0.1612903225806451 0.8387096774193549 0.0154416436292901 0.0399576465987978 0.0276996451140439 0.0245160029695077 0 0 0 0 K01239 0.1228571428571428 0.2621082621082621 E3.2.2.1; purine nucleosidase [EC:3.2.2.1] path:map00230,path:map01100,path:map01110,path:map01232 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 104.0 197.0 191.0 5.0 0.933649289099526 F 65.0 146.0 5.0 0.928909952606635 COG1957 Inosine-uridine_nucleoside_N-ribohydrolase URH1 211.0 0.3080568720379147 0.6919431279620853 0.916834097258018 0.900521254075844 0.908677675666931 0.0163128431821739 1 1 1 1 K01240 0.0028571428571428 0.0 URH1; uridine nucleosidase [EC:3.2.2.3] path:map00240,path:map00760,path:map01100,path:map01232 Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Nucleotide metabolism 323.0 1.0 0.0 1.0 1.0 F 1.0 0.0 1.0 1.0 COG1957 Inosine-uridine_nucleoside_N-ribohydrolase URH1 1.0 1.0 0.0 0 0 0 0 K01241 0.0 0.1196581196581196 amn; AMP nucleosidase [EC:3.2.2.4] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 238.0 44.0 0.0 1.0 1.0 F 0.0 44.0 2.0 0.5 COG0775 Nucleoside_phosphorylase/nucleosidase,_includes_5'-methylthioadenosine/S-adenosylhomocysteine_nucleosidase_MtnN_and_futalosine_hydrolase_MqnB MtnN 44.0 0.0 1.0 0.0460364623045589 0.0351090374276845 0.0405727498661217 0.0109274248768743 0 0 0 0 K01243 0.0342857142857142 0.4159544159544159 mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9] path:map00270,path:map01100,path:map01230 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids 68.0 113.0 59.0 4.0 0.624309392265193 F 15.0 166.0 6.0 0.878453038674033 COG0775 Nucleoside_phosphorylase/nucleosidase,_includes_5'-methylthioadenosine/S-adenosylhomocysteine_nucleosidase_MtnN_and_futalosine_hydrolase_MqnB MtnN 181.0 0.0828729281767955 0.9171270718232044 0.646341277956191 0.594875968223406 0.6206086230897985 0.0514653097327849 0 1 0 1 K01246 0.1314285714285714 0.4102564102564102 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] path:map03410 Base excision repair 136.0 198.0 185.0 3.0 0.933962264150943 L 53.0 159.0 3.0 0.924528301886792 COG2818 3-methyladenine_DNA_glycosylase_Tag Tag 212.0 0.25 0.75 0.03206499823218 0.217294630595507 0.1246798144138435 0.1852296323633269 0 0 0 0 K01247 0.2657142857142857 0.3304843304843304 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21] path:map03410 Base excision repair 86.0 221.0 212.0 3.0 0.952586206896552 L 102.0 130.0 2.0 0.995689655172414 COG0122 3-methyladenine_DNA_glycosylase/8-oxoguanine_DNA_glycosylase AlkA 232.0 0.4396551724137931 0.5603448275862069 0.61873578620934 0.505565931616161 0.5621508589127505 0.1131698545931789 0 1 0 1 K01250 0.0228571428571428 0.1823361823361823 rihA; pyrimidine-specific ribonucleoside hydrolase [EC:3.2.2.-] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 140.0 76.0 69.0 4.0 0.853932584269663 F 9.0 80.0 2.0 0.966292134831461 COG1957 Inosine-uridine_nucleoside_N-ribohydrolase URH1 89.0 0.1011235955056179 0.898876404494382 0.825028051478887 0.971899503598406 0.8984637775386466 0.146871452119519 1 1 1 1 K01251 0.7742857142857142 0.7065527065527065 AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 279.0 547.0 526.0 3.0 0.936643835616438 H 307.0 277.0 2.0 0.972602739726027 COG0499 S-adenosylhomocysteine_hydrolase SAM1 584.0 0.5256849315068494 0.4743150684931507 0.845439987266896 0.95555327383739 0.9004966305521429 0.110113286570494 1 1 1 1 K01252 0.0 0.037037037037037 entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 211.0 15.0 0.0 1.0 1.0 Q 0.0 15.0 1.0 1.0 COG1535 Isochorismate_hydrolase EntB1 15.0 0.0 1.0 0.0025800806528551 0.0085586035209502 0.0055693420869026 0.005978522868095 0 0 0 0 K01253 0.0085714285714285 0.0541310541310541 EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9] path:map00980,path:map04976,path:map05204,path:map05207,path:map05208 Metabolism of xenobiotics by cytochrome P450,Bile secretion,Chemical carcinogenesis - DNA adducts,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species 227.0 19.0 15.0 6.0 0.59375 S 3.0 29.0 4.0 0.84375 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 32.0 0.09375 0.90625 0.0127410688163638 0.354787103444676 0.1837640861305199 0.3420460346283122 0 0 0 0 K01255 0.1685714285714285 0.6410256410256411 CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 236.0 338.0 327.0 2.0 0.968481375358166 E 59.0 290.0 1.0 1.0 COG0260 Leucyl_aminopeptidase PepB 349.0 0.1690544412607449 0.830945558739255 0.0680592917958524 0.8849336491358 0.4764964704658262 0.8168743573399475 0 0 0 0 K01256 0.1685714285714285 0.4415954415954416 pepN; aminopeptidase N [EC:3.4.11.2] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 121.0 245.0 218.0 8.0 0.844827586206896 E 65.0 222.0 5.0 0.958620689655172 COG0308 Aminopeptidase_N,_contains_DUF3458_domain PepN 287.0 0.2264808362369338 0.7735191637630662 0.0093115826813493 0.195825491351569 0.1025685370164591 0.1865139086702197 0 0 0 0 K01258 0.0257142857142857 0.3333333333333333 pepT; tripeptide aminopeptidase [EC:3.4.11.4] 260.0 159.0 158.0 2.0 0.99375 E 9.0 151.0 1.0 1.0 COG2195 Di-_or_tripeptidase PepD2 160.0 0.05625 0.94375 0.329072478730137 0.799324217669963 0.56419834820005 0.4702517389398259 0 0 0 0 K01259 0.1142857142857142 0.3561253561253561 pip; proline iminopeptidase [EC:3.4.11.5] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 44.0 76.0 0.0 6.0 0.32618025751073 E 47.0 186.0 8.0 0.502145922746781 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 233.0 0.2017167381974249 0.7982832618025751 0.0242176501632621 0.129941646223195 0.0770796481932285 0.1057239960599329 0 0 0 0 K01261 0.0 0.0427350427350427 pepA; glutamyl aminopeptidase [EC:3.4.11.7] 319.0 16.0 14.0 2.0 0.888888888888889 G 0.0 18.0 1.0 1.0 COG1363 Putative_aminopeptidase_FrvX FrvX 18.0 0.0 1.0 0.0005219959431319 0.0055179203844737 0.0030199581638028 0.0049959244413418 0 0 0 0 K01262 0.4971428571428571 0.905982905982906 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] 54.0 676.0 665.0 2.0 0.983988355167394 E 234.0 453.0 1.0 1.0 COG0006 Xaa-Pro_aminopeptidase PepP 687.0 0.3406113537117904 0.6593886462882096 0.101222526189487 0.399048293825283 0.250135410007385 0.297825767635796 0 0 0 0 K01263 0.0 0.0541310541310541 321.0 20.0 19.0 2.0 0.952380952380952 E 0.0 21.0 2.0 0.666666666666667 COG2195 Di-_or_tripeptidase PepD2 21.0 0.0 1.0 0.0067329676922791 0.0174261071726798 0.0120795374324794 0.0106931394804007 0 0 0 0 K01264 0.0 0.0085470085470085 APE3; aminopeptidase Y [EC:3.4.11.15] 491.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 4.0 0.0 1.0 0.0380595584412892 0.0830684141101392 0.0605639862757142 0.04500885566885 0 0 0 0 K01265 0.8914285714285715 0.9886039886039886 map; methionyl aminopeptidase [EC:3.4.11.18] 111.0 566.0 316.0 2.0 0.693627450980392 E 351.0 465.0 1.0 1.0 COG0024 Methionine_aminopeptidase Map 816.0 0.4301470588235294 0.5698529411764706 0.704821047661754 0.758073537715052 0.731447292688403 0.053252490053298 0 1 0 1 K01266 0.0342857142857142 0.168091168091168 dmpA, dap; D-aminopeptidase [EC:3.4.11.19] 217.0 59.0 43.0 4.0 0.670454545454545 EQ 12.0 76.0 3.0 0.852272727272727 COG3191 L-aminopeptidase/D-esterase DmpA 88.0 0.1363636363636363 0.8636363636363636 0.330811662745485 0.630720001952165 0.480765832348825 0.29990833920668 0 0 0 0 K01267 0.0342857142857142 0.1424501424501424 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21] 330.0 56.0 48.0 2.0 0.875 E 12.0 52.0 2.0 0.8125 COG1362 Aspartyl_aminopeptidase LAP4 64.0 0.1875 0.8125 0.0752834367001722 0.497795924634008 0.2865396806670901 0.4225124879338358 0 0 0 0 K01269 0.0 0.0854700854700854 yhfE; aminopeptidase [EC:3.4.11.-] 213.0 18.0 5.0 3.0 0.5625 G 0.0 32.0 3.0 0.625 COG1363 Putative_aminopeptidase_FrvX FrvX 32.0 0.0 1.0 0.0141499520505418 0.0342025276893902 0.024176239869966 0.0200525756388484 0 0 0 0 K01270 0.0514285714285714 0.1994301994301994 pepD; dipeptidase D [EC:3.4.13.-] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 306.0 104.0 0.0 1.0 1.0 E 21.0 83.0 2.0 0.923076923076923 COG2195 Di-_or_tripeptidase PepD2 104.0 0.2019230769230769 0.7980769230769231 0.0395700155062996 0.690769150382246 0.3651695829442727 0.6511991348759464 0 0 0 0 K01271 0.5428571428571428 0.5128205128205128 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9] 73.0 506.0 476.0 2.0 0.944029850746269 E 245.0 291.0 3.0 0.936567164179104 COG0006 Xaa-Pro_aminopeptidase PepP 536.0 0.457089552238806 0.542910447761194 0.494146149732093 0.865792950421376 0.6799695500767345 0.3716468006892831 0 0 0 0 K01273 0.1457142857142857 0.3817663817663818 DPEP; membrane dipeptidase [EC:3.4.13.19] 121.0 257.0 256.0 2.0 0.996124031007752 E 69.0 189.0 2.0 0.996124031007752 COG2355 Zn-dependent_dipeptidase,_microsomal_dipeptidase_homolog 258.0 0.2674418604651162 0.7325581395348837 0.251053301536946 0.946247096379093 0.5986501989580195 0.6951937948421469 0 0 0 0 K01274 0.0 0.0826210826210826 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-] 212.0 30.0 0.0 1.0 1.0 E 0.0 30.0 4.0 0.4 COG0006 Xaa-Pro_aminopeptidase PepP 30.0 0.0 1.0 0.0096404746453203 0.017793536714894 0.0137170056801071 0.0081530620695737 0 0 0 0 K01277 0.0 0.0341880341880341 DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] 649.0 12.0 11.0 2.0 0.923076923076923 S 0.0 13.0 2.0 0.923076923076923 COG0457 Tetratricopeptide_(TPR)_repeat TPR 13.0 0.0 1.0 0.021636419072698 0.057594463398439 0.0396154412355685 0.035958044325741 0 0 0 0 K01278 0.0142857142857142 0.2051282051282051 DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5] path:map04974 Protein digestion and absorption 192.0 65.0 20.0 5.0 0.570175438596491 E 5.0 114.0 8.0 0.504201680672269 COG0823 Periplasmic_component_TolB_of_the_Tol_biopolymer_transport_system TolB 119.0 0.042016806722689 0.957983193277311 0.0055451680028609 0.0659832862461666 0.0357642271245137 0.0604381182433057 0 0 0 0 K01280 0.0 0.0113960113960113 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10] 46.0 4.0 0.0 1.0 1.0 O 0.0 4.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 4.0 0.0 1.0 0.163472412270726 0.292276998699777 0.2278747054852515 0.128804586429051 0 0 0 0 K01281 0.06 0.0598290598290598 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11] 368.0 41.0 22.0 4.0 0.661290322580645 S 36.0 26.0 6.0 0.854838709677419 COG2936 Predicted_acyl_esterase 62.0 0.5806451612903226 0.4193548387096774 0.0881582955463795 0.0385004718025637 0.0633293836744715 0.0496578237438158 0 0 0 0 K01283 0.0057142857142857 0.0626780626780626 ACE, CD143; peptidyl-dipeptidase A [EC:3.4.15.1] path:map04614,path:map04924,path:map05142,path:map05171,path:map05410,path:map05415 Renin-angiotensin system,Renin secretion,Chagas disease,Coronavirus disease - COVID-19,Hypertrophic cardiomyopathy,Diabetic cardiomyopathy 472.0 26.0 0.0 1.0 1.0 E 2.0 24.0 1.0 1.0 COG1164 Oligoendopeptidase_F PepF 26.0 0.0769230769230769 0.9230769230769232 0.154308941147116 0.126315331760737 0.1403121364539264 0.0279936093863789 0 0 0 0 K01284 0.0028571428571428 0.1794871794871795 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] 618.0 84.0 0.0 1.0 1.0 E 1.0 83.0 2.0 0.988095238095238 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 84.0 0.0119047619047619 0.988095238095238 0.0140528967833263 0.0256186890264533 0.0198357929048898 0.011565792243127 0 0 0 0 K01286 0.0285714285714285 0.3561253561253561 E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4] 20.0 110.0 1.0 9.0 0.458333333333333 V 10.0 228.0 12.0 0.475 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 238.0 0.042016806722689 0.957983193277311 0.0137069205284741 0.0178697814760994 0.0157883510022867 0.0041628609476253 0 0 0 0 K01291 0.0057142857142857 0.0 CPB1; carboxypeptidase B [EC:3.4.17.2] path:map04972,path:map04974 Pancreatic secretion,Protein digestion and absorption 438.0 2.0 0.0 1.0 1.0 O 2.0 0.0 1.0 1.0 COG2866 Murein_tripeptide_amidase_MpaA MpaA 2.0 1.0 0.0 0 0 0 0 K01292 0.0 0.0028490028490028 CPN1; carboxypeptidase N catalytic subunit [EC:3.4.17.3] 322.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 KOG1934 1.0 0.0 1.0 0 0 0 0 K01294 0.0 0.0028490028490028 CPE; carboxypeptidase E [EC:3.4.17.10] path:map04940 Type I diabetes mellitus 322.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 KOG1934 1.0 0.0 1.0 0 0 0 0 K01295 0.0228571428571428 0.1908831908831909 cpg; glutamate carboxypeptidase [EC:3.4.17.11] 215.0 85.0 82.0 5.0 0.934065934065934 E 8.0 83.0 4.0 0.945054945054945 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 91.0 0.0879120879120879 0.912087912087912 0.0374108963232623 0.792474471570992 0.4149426839471272 0.7550635752477297 0 0 0 0 K01296 0.0028571428571428 0.0 CPM; carboxypeptidase M [EC:3.4.17.12] 459.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG2649 1.0 1.0 0.0 0 0 0 0 K01297 0.0885714285714285 0.3874643874643874 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] 125.0 194.0 190.0 3.0 0.96039603960396 V 36.0 166.0 3.0 0.975247524752475 COG1619 Muramoyltetrapeptide_carboxypeptidase_LdcA_(peptidoglycan_recycling) LdcA 202.0 0.1782178217821782 0.8217821782178217 0.031496079962836 0.155503989787563 0.0935000348751995 0.124007909824727 0 0 0 0 K01298 0.0057142857142857 0.0 CPA2; carboxypeptidase A2 [EC:3.4.17.15] path:map04972,path:map04974 Pancreatic secretion,Protein digestion and absorption 438.0 2.0 0.0 1.0 1.0 O 2.0 0.0 1.0 1.0 COG2866 Murein_tripeptide_amidase_MpaA MpaA 2.0 1.0 0.0 0 0 0 0 K01299 0.3542857142857142 0.2592592592592592 E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19] 358.0 215.0 181.0 2.0 0.863453815261044 E 150.0 99.0 2.0 0.995983935742972 COG2317 Zn-dependent_carboxypeptidase,_M32_family YpwA 249.0 0.6024096385542169 0.3975903614457831 0.710841173822223 0.734521591310505 0.722681382566364 0.0236804174882819 0 1 0 1 K01301 0.0028571428571428 0.0512820512820512 NAALAD; N-acetylated-alpha-linked acidic dipeptidase [EC:3.4.17.21] 616.0 18.0 15.0 2.0 0.857142857142857 S 1.0 20.0 1.0 1.0 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 21.0 0.0476190476190476 0.9523809523809524 0.0144425128136637 0.0271753521813289 0.0208089324974963 0.0127328393676652 0 0 0 0 K01303 0.1114285714285714 0.0968660968660968 APEH; acylaminoacyl-peptidase [EC:3.4.19.1] 225.0 73.0 51.0 2.0 0.768421052631579 E 58.0 37.0 2.0 0.642105263157895 COG1506 Dipeptidyl_aminopeptidase/acylaminoacyl_peptidase DAP2 95.0 0.6105263157894737 0.3894736842105263 0.346252770931055 0.988001243425263 0.667127007178159 0.641748472494208 0 0 0 0 K01304 0.1485714285714285 0.1823361823361823 pcp; pyroglutamyl-peptidase [EC:3.4.19.3] 111.0 115.0 111.0 3.0 0.950413223140496 O 56.0 65.0 1.0 1.0 COG2039 Pyrrolidone-carboxylate_peptidase_(N-terminal_pyroglutamyl_peptidase) Pcp 121.0 0.4628099173553719 0.5371900826446281 0.722195117735942 0.919795831576649 0.8209954746562955 0.197600713840707 0 1 0 1 K01305 0.0028571428571428 0.0911680911680911 iadA; beta-aspartyl-dipeptidase (metallo-type) [EC:3.4.19.-] 349.0 18.0 5.0 5.0 0.486486486486487 F 1.0 36.0 5.0 0.567567567567568 COG0044 Dihydroorotase_or_related_cyclic_amidohydrolase AllB 37.0 0.027027027027027 0.972972972972973 0.705875181486404 0.854132914502165 0.7800040479942845 0.1482577330157609 0 0 0 1 K01308 0.0 0.0341880341880341 yqgT; g-D-glutamyl-meso-diaminopimelate peptidase [EC:3.4.19.11] 273.0 7.0 1.0 3.0 0.5 E 0.0 14.0 2.0 0.642857142857143 COG2866 Murein_tripeptide_amidase_MpaA MpaA 14.0 0.0 1.0 0.0187407835433277 0.0554855540001529 0.0371131687717403 0.0367447704568252 0 0 0 0 K01312 0.0 0.0227920227920227 PRSS1_2_3; trypsin [EC:3.4.21.4] path:map04080,path:map04972,path:map04974,path:map05164 Neuroactive ligand-receptor interaction,Pancreatic secretion,Protein digestion and absorption,Influenza A 249.0 12.0 0.0 1.0 1.0 O 0.0 12.0 3.0 0.75 COG5640 Secreted_trypsin-like_serine_protease 12.0 0.0 1.0 0.038532751536115 0.102909649903934 0.0707212007200245 0.064376898367819 0 0 0 0 K01317 0.0085714285714285 0.0256410256410256 ACR; acrosin [EC:3.4.21.10] 127.0 6.0 3.0 5.0 0.461538461538462 M 3.0 9.0 4.0 0.769230769230769 COG1572 Serine_protease,_subtilase_family 12.0 0.25 0.75 0.104466001178927 0.342516940372652 0.2234914707757895 0.238050939193725 0 0 0 0 K01318 0.0 0.0398860398860398 sspA; glutamyl endopeptidase [EC:3.4.21.19] path:map02024 Quorum sensing 152.0 19.0 17.0 2.0 0.904761904761905 E 0.0 21.0 1.0 1.0 COG3591 V8-like_Glu-specific_endopeptidase eMpr 21.0 0.0 1.0 0.0173447444919941 0.0384267637063587 0.0278857540991764 0.0210820192143646 0 0 0 0 K01322 0.12 0.2592592592592592 PREP; prolyl oligopeptidase [EC:3.4.21.26] path:map04614 Renin-angiotensin system 301.0 168.0 0.0 1.0 1.0 E 47.0 121.0 4.0 0.880952380952381 COG1505 Prolyl_endopeptidase_PreP,_S9A_serine_peptidase_family PreP 168.0 0.2797619047619047 0.7202380952380952 0.0110517282971112 0.190675816407182 0.1008637723521466 0.1796240881100708 0 0 0 0 K01325 0.0 0.0056980056980056 KLK1_2; tissue kallikrein [EC:3.4.21.35] path:map04614,path:map04961 Renin-angiotensin system,Endocrine and other factor-regulated calcium reabsorption 258.0 1.0 0.0 2.0 0.5 M 0.0 2.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 2.0 0.0 1.0 0 0 0 0 K01337 0.0057142857142857 0.0797720797720797 E3.4.21.50; lysyl endopeptidase [EC:3.4.21.50] 35.0 15.0 3.0 9.0 0.294117647058824 S 3.0 48.0 12.0 0.215686274509804 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 51.0 0.0588235294117647 0.9411764705882352 0.0033127512269456 0.0081880229077501 0.0057503870673478 0.0048752716808045 0 0 0 0 K01338 0.2057142857142857 0.8262108262108262 lon; ATP-dependent Lon protease [EC:3.4.21.53] path:map04112 Cell cycle - Caulobacter 50.0 556.0 463.0 6.0 0.838612368024133 O 91.0 554.0 10.0 0.681749622926094 COG0466 ATP-dependent_Lon_protease,_bacterial_type Lon 645.0 0.1410852713178294 0.8589147286821706 0.0306168584421532 0.347392984407929 0.1890049214250411 0.3167761259657757 0 0 0 0 K01340 0.0 0.0028490028490028 E3.4.21.59; tryptase [EC:3.4.21.59] path:map05164 Influenza A 374.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 1.0 0.0 1.0 0 0 0 0 K01342 0.1057142857142857 0.0826210826210826 aprE; subtilisin [EC:3.4.21.62] 136.0 81.0 77.0 2.0 0.952941176470588 O 51.0 34.0 4.0 0.941176470588235 COG1404 Serine_protease,_subtilisin_family AprE 85.0 0.6 0.4 0.0779277921708579 0.408749225143419 0.2433385086571384 0.330821432972561 0 0 0 0 K01343 0.0 0.0028490028490028 PLAT; tissue plasminogen activator [EC:3.4.21.68] path:map04371,path:map04610,path:map05202,path:map05215,path:map05418 Apelin signaling pathway,Complement and coagulation cascades,Transcriptional misregulation in cancer,Prostate cancer,Fluid shear stress and atherosclerosis 508.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0056 FoF1-type_ATP_synthase,_alpha_subunit AtpA 1.0 0.0 1.0 0 0 0 0 K01346 0.0 0.0056980056980056 CELA2; pancreatic elastase II [EC:3.4.21.71] path:map04972,path:map04974 Pancreatic secretion,Protein digestion and absorption 260.0 1.0 0.0 2.0 0.5 M 0.0 2.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 2.0 0.0 1.0 0 0 0 0 K01347 0.0 0.0113960113960113 iga; IgA-specific serine endopeptidase [EC:3.4.21.72] 130.0 1.0 0.0 4.0 0.25 N 0.0 4.0 3.0 0.5 COG1196 Chromosome_segregation_ATPase_Smc Smc 4.0 0.0 1.0 0.13447535532039 0.207241125879978 0.170858240600184 0.072765770559588 0 0 0 0 K01354 0.0114285714285714 0.2222222222222222 ptrB; oligopeptidase B [EC:3.4.21.83] path:map05142,path:map05143 Chagas disease,African trypanosomiasis 576.0 86.0 0.0 1.0 1.0 E 4.0 82.0 2.0 0.988372093023256 COG1770 Protease_II PtrB 86.0 0.0465116279069767 0.9534883720930232 0.39243436617215 0.959259166522168 0.675846766347159 0.566824800350018 0 0 0 0 K01355 0.0 0.0113960113960113 ompT; omptin [EC:3.4.23.49] 283.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG4571 Outer_membrane_protease OmpT 7.0 0.0 1.0 0.0094146175475708 0.0168159313174003 0.0131152744324855 0.0074013137698295 0 0 0 0 K01356 0.0114285714285714 0.7464387464387464 lexA; repressor LexA [EC:3.4.21.88] 67.0 301.0 285.0 4.0 0.903903903903904 K 5.0 328.0 6.0 0.930930930930931 COG1974 SOS-response_transcriptional_repressor_LexA_(RecA-mediated_autopeptidase) LexA 333.0 0.015015015015015 0.984984984984985 0.606311086063302 0.627866938595748 0.617089012329525 0.021555852532446 0 1 0 1 K01358 0.0142857142857142 0.9487179487179488 clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] path:map04112,path:map04212 Cell cycle - Caulobacter,Longevity regulating pathway - worm 132.0 296.0 64.0 3.0 0.559546313799622 OU 6.0 523.0 1.0 1.0 COG0740 ATP-dependent_protease_ClpP,_protease_subunit ClpP 529.0 0.0113421550094517 0.9886578449905482 0.888660699939956 0.349089116081076 0.618874908010516 0.5395715838588799 1 1 1 1 K01361 0.0142857142857142 0.1111111111111111 E3.4.21.96; lactocepin [EC:3.4.21.96] 73.0 32.0 21.0 10.0 0.450704225352113 O 5.0 66.0 10.0 0.563380281690141 COG1404 Serine_protease,_subtilisin_family AprE 71.0 0.0704225352112676 0.9295774647887324 0.116936715290489 0.0689603499138773 0.0929485326021831 0.0479763653766117 0 0 0 0 K01365 0.0085714285714285 0.0113960113960113 CTSL; cathepsin L [EC:3.4.22.15] path:map04140,path:map04142,path:map04145,path:map04210,path:map04612,path:map05205,path:map05323,path:map05418 Autophagy - animal,Lysosome,Phagosome,Apoptosis,Antigen processing and presentation,Proteoglycans in cancer,Rheumatoid arthritis,Fluid shear stress and atherosclerosis 211.0 6.0 5.0 2.0 0.857142857142857 O 3.0 4.0 2.0 0.714285714285714 COG4870 Cysteine_protease,_C1A_family 7.0 0.4285714285714285 0.5714285714285714 0.504533022018013 0.292643637587185 0.3985883298025989 0.211889384430828 0 0 0 1 K01371 0.0028571428571428 0.0056980056980056 CTSK; cathepsin K [EC:3.4.22.38] path:map04142,path:map04210,path:map04380,path:map04620,path:map05323 Lysosome,Apoptosis,Osteoclast differentiation,Toll-like receptor signaling pathway,Rheumatoid arthritis 44.0 3.0 0.0 1.0 1.0 O 1.0 2.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K01372 0.0228571428571428 0.0911680911680911 BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40] 270.0 51.0 49.0 2.0 0.962264150943396 E 8.0 45.0 1.0 1.0 COG3579 Aminopeptidase_C PepC 53.0 0.1509433962264151 0.8490566037735849 0.0106786638968525 0.0172029942682199 0.0139408290825362 0.0065243303713674 0 0 0 0 K01373 0.0028571428571428 0.0 CTSF; cathepsin F [EC:3.4.22.41] path:map04142,path:map04210,path:map04626 Lysosome,Apoptosis,Plant-pathogen interaction 759.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K01385 0.1171428571428571 0.0 E3.4.23.42; thermopsin [EC:3.4.23.42] 90.0 44.0 19.0 6.0 0.564102564102564 E 81.0 0.0 10.0 0.304878048780488 arCOG03670 81.0 1.0 0.0 0.0187622978083763 0.0289225728224702 0.0238424353154232 0.0101602750140939 0 0 0 0 K01387 0.0085714285714285 0.0626780626780626 colA; microbial collagenase [EC:3.4.24.3] 16.0 15.0 7.0 8.0 0.441176470588235 C 3.0 33.0 9.0 0.45945945945946 COG1413 HEAT_repeat HEAT 36.0 0.0833333333333333 0.9166666666666666 0.0411611232833627 0.0573143380806711 0.0492377306820169 0.0161532147973084 0 0 0 0 K01388 0.0028571428571428 0.0 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7] path:map03320,path:map04657,path:map04926,path:map05171,path:map05200,path:map05219,path:map05323,path:map05417 PPAR signaling pathway,IL-17 signaling pathway,Relaxin signaling pathway,Coronavirus disease - COVID-19,Pathways in cancer,Bladder cancer,Rheumatoid arthritis,Lipid and atherosclerosis 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K01389 0.0 0.0455840455840455 MME, CD10; neprilysin [EC:3.4.24.11] path:map04614,path:map04640,path:map04974,path:map05010 Renin-angiotensin system,Hematopoietic cell lineage,Protein digestion and absorption,Alzheimer disease 634.0 16.0 0.0 1.0 1.0 O 0.0 16.0 1.0 1.0 COG3590 Predicted_metalloendopeptidase PepO 16.0 0.0 1.0 6.1250544282421495e-12 1.09123782775091e-07 5.4564953914759625e-08 1.0911765772066276e-07 0 0 0 0 K01390 0.0 0.0028490028490028 iga; IgA-specific metalloendopeptidase [EC:3.4.24.13] 145.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3583 Uncharacterized_conserved_protein_YabE,_contains_G5_and_tandem_DUF348_domains YabE 1.0 0.0 1.0 0 0 0 0 K01392 0.0057142857142857 0.0398860398860398 THOP1; thimet oligopeptidase [EC:3.4.24.15] path:map04614,path:map05143 Renin-angiotensin system,African trypanosomiasis 608.0 13.0 8.0 2.0 0.722222222222222 E 2.0 16.0 1.0 1.0 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 18.0 0.1111111111111111 0.8888888888888888 0.0303903662463976 0.0857810409499614 0.0580857035981795 0.0553906747035638 0 0 0 0 K01393 0.0057142857142857 0.0056980056980056 NLN; neurolysin [EC:3.4.24.16] path:map04614 Renin-angiotensin system 298.0 4.0 0.0 1.0 1.0 O 2.0 2.0 1.0 1.0 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 4.0 0.5 0.5 0.0532376197056045 0.105311440929576 0.0792745303175902 0.0520738212239715 0 0 0 0 K01394 0.0028571428571428 0.0 MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17] path:map04657,path:map04668,path:map05171,path:map05202,path:map05215,path:map05323,path:map05417 IL-17 signaling pathway,TNF signaling pathway,Coronavirus disease - COVID-19,Transcriptional misregulation in cancer,Prostate cancer,Rheumatoid arthritis,Lipid and atherosclerosis 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K01396 0.0028571428571428 0.0 MMP10; matrix metalloproteinase-10 (stromelysin 2) [EC:3.4.24.22] 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K01399 0.0 0.0056980056980056 lasB; pseudolysin [EC:3.4.24.26] path:map01503,path:map02024 Cationic antimicrobial peptide (CAMP) resistance,Quorum sensing 498.0 2.0 1.0 2.0 0.666666666666667 E 0.0 3.0 1.0 1.0 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 3.0 0.0 1.0 0 0 0 0 K01400 0.0085714285714285 0.0512820512820512 nprE; bacillolysin [EC:3.4.24.28] 171.0 23.0 20.0 3.0 0.851851851851852 E 4.0 23.0 5.0 0.666666666666667 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 27.0 0.1481481481481481 0.8518518518518519 0.0515206465249855 0.110817302731771 0.0811689746283782 0.0592966562067854 0 0 0 0 K01401 0.0028571428571428 0.0028490028490028 aur; aureolysin [EC:3.4.24.29] path:map01503,path:map05150 Cationic antimicrobial peptide (CAMP) resistance,Staphylococcus aureus infection 75.0 2.0 0.0 1.0 1.0 E 1.0 1.0 2.0 0.5 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 2.0 0.5 0.5 0 0 0 0 K01402 0.0028571428571428 0.0 MMP8; matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34] 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K01405 0.0114285714285714 0.0056980056980056 PRD1; saccharolysin [EC:3.4.24.37] 653.0 7.0 0.0 1.0 1.0 O 5.0 2.0 1.0 1.0 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 7.0 0.7142857142857143 0.2857142857142857 0.0234192347283894 0.0438548550305653 0.0336370448794773 0.0204356203021758 0 0 0 0 K01406 0.0 0.0 prtC; serralysin [EC:3.4.24.40] path:map01503 Cationic antimicrobial peptide (CAMP) resistance 65.0 47.0 11.0 0.460992907801418 Q 0.0 0.0 28.0 0.328671328671329 COG2931 Ca2+-binding_protein,_RTX_toxin-related 0.0 0 0 0 0 K01407 0.0 0.0199430199430199 ptrA; protease III [EC:3.4.24.55] 930.0 5.0 3.0 2.0 0.714285714285714 O 0.0 7.0 1.0 1.0 COG1025 Secreted/periplasmic_Zn-dependent_peptidases,_insulinase-like Ptr 7.0 0.0 1.0 0.0266152808214715 0.0523907478884602 0.0395030143549658 0.0257754670669887 0 0 0 0 K01408 0.0 0.0113960113960113 IDE, ide; insulysin [EC:3.4.24.56] path:map05010 Alzheimer disease 909.0 4.0 0.0 1.0 1.0 O 0.0 4.0 1.0 1.0 COG1025 Secreted/periplasmic_Zn-dependent_peptidases,_insulinase-like Ptr 4.0 0.0 1.0 0.0736660234849289 0.139251786317479 0.1064589049012039 0.0655857628325501 0 0 0 0 K01409 0.5114285714285715 0.9914529914529916 OSGEP, KAE1, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] 133.0 322.0 19.0 6.0 0.49922480620155 J 184.0 461.0 3.0 0.851162790697674 COG0533 tRNA_A37_threonylcarbamoyltransferase_TsaD TsaD 645.0 0.2852713178294573 0.7147286821705426 0.503945350443725 0.547092540933788 0.5255189456887566 0.0431471904900629 0 1 0 1 K01412 0.0114285714285714 0.0 PMPCA, MAS2; mitochondrial-processing peptidase subunit alpha [EC:3.4.24.64] 94.0 3.0 1.0 2.0 0.6 J 5.0 0.0 2.0 0.6 COG2451 Ribosomal_protein_L35AE/L33A Rpl35A 5.0 1.0 0.0 1.85009644944595e-05 6.16143724641686e-13 9.250482555301612e-06 1.850096387831577e-05 0 0 0 0 K01414 0.0028571428571428 0.2108262108262108 prlC; oligopeptidase A [EC:3.4.24.70] 586.0 79.0 0.0 1.0 1.0 E 1.0 78.0 1.0 1.0 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 79.0 0.0126582278481012 0.9873417721518988 0.0062885845371751 0.0189745948647559 0.0126315897009655 0.0126860103275808 0 0 0 0 K01415 0.0028571428571428 0.1139601139601139 ECE; endothelin-converting enzyme [EC:3.4.24.71] 572.0 49.0 0.0 1.0 1.0 O 1.0 48.0 1.0 1.0 COG3590 Predicted_metalloendopeptidase PepO 49.0 0.0204081632653061 0.979591836734694 0.0080448252455975 0.0164533652452596 0.0122490952454285 0.0084085399996621 0 0 0 0 K01416 0.0 0.0142450142450142 snpA; snapalysin [EC:3.4.24.77] 6.0 7.0 0.0 1.0 1.0 O 0.0 7.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 7.0 0.0 1.0 1.45564678138351e-05 0.0004275765479152 0.0002210665078645 0.0004130200801013 0 0 0 0 K01417 0.0 0.0113960113960113 MEP; extracellular elastinolytic metalloproteinase [EC:3.4.24.-] 481.0 2.0 1.0 3.0 0.5 E 0.0 4.0 2.0 0.75 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 4.0 0.0 1.0 0.0479301214689787 0.113292125013883 0.0806111232414308 0.0653620035449042 0 0 0 0 K01419 0.0 0.4928774928774929 hslV, clpQ; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2] 147.0 171.0 167.0 2.0 0.977142857142857 O 0.0 175.0 1.0 1.0 COG5405 ATP-dependent_protease_HslVU_(ClpYQ),_peptidase_subunit HslV 175.0 0.0 1.0 0.0085018198502308 0.21622813276049 0.1123649763053604 0.2077263129102592 0 0 0 0 K01420 0.0057142857142857 0.3618233618233618 fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein 50.0 161.0 113.0 3.0 0.766666666666667 K 3.0 207.0 2.0 0.995238095238095 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 210.0 0.0142857142857142 0.9857142857142858 0.0035384105151219 0.162644670047827 0.0830915402814744 0.1591062595327051 0 0 0 0 K01421 0.0171428571428571 0.1652421652421652 yhgE; putative membrane protein 130.0 62.0 54.0 6.0 0.71264367816092 S 6.0 81.0 3.0 0.908045977011494 COG1511 Uncharacterized_membrane_protein_YhgE,_phage_infection_protein_(PIP)_family YhgE 87.0 0.0689655172413793 0.9310344827586208 0.613750803445275 0.0969186389075307 0.3553347211764028 0.5168321645377443 0 1 0 1 K01424 0.2257142857142857 0.50997150997151 E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1] path:map00250,path:map00460,path:map01100,path:map01110 Alanine, aspartate and glutamate metabolism,Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 82.0 198.0 70.0 3.0 0.6 EJ 102.0 226.0 4.0 0.684848484848485 COG0252 L-asparaginase/archaeal_Glu-tRNAGln_amidotransferase_subunit_D AnsA 328.0 0.3109756097560975 0.6890243902439024 0.0497286193500988 0.724064859589849 0.3868967394699739 0.6743362402397503 0 0 0 0 K01425 0.0114285714285714 0.225071225071225 glsA, GLS; glutaminase [EC:3.5.1.2] path:map00220,path:map00250,path:map00470,path:map01100,path:map02020,path:map04724,path:map04727,path:map04964,path:map05206,path:map05230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,D-Amino acid metabolism,Metabolic pathways,Two-component system,Glutamatergic synapse,GABAergic synapse,Proximal tubule bicarbonate reclamation,MicroRNAs in cancer,Central carbon metabolism in cancer 210.0 88.0 77.0 3.0 0.88 E 4.0 96.0 4.0 0.87 COG2066 Glutaminase GlsA 100.0 0.04 0.96 0.0643372489204629 0.102267300269092 0.0833022745947774 0.0379300513486291 0 0 0 0 K01426 0.1628571428571428 0.376068376068376 E3.5.1.4, amiE; amidase [EC:3.5.1.4] path:map00330,path:map00360,path:map00380,path:map00627,path:map00643,path:map01100,path:map01120 Arginine and proline metabolism,Phenylalanine metabolism,Tryptophan metabolism,Aminobenzoate degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 68.0 291.0 228.0 5.0 0.782258064516129 J 83.0 289.0 4.0 0.782258064516129 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 372.0 0.2231182795698924 0.7768817204301075 0.143897652771525 0.142176458878574 0.1430370558250495 0.001721193892951 0 0 0 0 K01427 0.0 0.0056980056980056 URE; urease [EC:3.5.1.5] path:map00220,path:map00230,path:map00791,path:map01100,path:map01120 Arginine biosynthesis,Purine metabolism,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 118.0 2.0 0.0 1.0 1.0 E 0.0 2.0 2.0 0.5 COG0804 Urease_alpha_subunit UreC 2.0 0.0 1.0 0 0 0 0 K01428 0.0685714285714285 0.2051282051282051 ureC; urease subunit alpha [EC:3.5.1.5] path:map00220,path:map00230,path:map00791,path:map01100,path:map01120,path:map05120 Arginine biosynthesis,Purine metabolism,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments,Epithelial cell signaling in Helicobacter pylori infection 546.0 104.0 0.0 1.0 1.0 E 25.0 79.0 2.0 0.990384615384615 COG0804 Urease_alpha_subunit UreC 104.0 0.2403846153846154 0.7596153846153846 0.0054655318006244 0.492571817905699 0.2490186748531617 0.4871062861050745 0 0 0 0 K01429 0.0657142857142857 0.1823361823361823 ureB; urease subunit beta [EC:3.5.1.5] path:map00220,path:map00230,path:map00791,path:map01100,path:map01120 Arginine biosynthesis,Purine metabolism,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 92.0 91.0 0.0 1.0 1.0 E 25.0 66.0 2.0 0.967032967032967 COG0832 Urease_beta_subunit UreB 91.0 0.2747252747252747 0.7252747252747253 0.0063389948613178 0.241483170062599 0.1239110824619584 0.2351441752012812 0 0 0 0 K01430 0.0685714285714285 0.188034188034188 ureA; urease subunit gamma [EC:3.5.1.5] path:map00220,path:map00230,path:map00791,path:map01100,path:map01120 Arginine biosynthesis,Purine metabolism,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 100.0 95.0 0.0 1.0 1.0 E 27.0 68.0 1.0 1.0 COG0831 Urease_gamma_subunit UreA 95.0 0.2842105263157894 0.7157894736842105 0.0083184442526892 0.185268318371016 0.0967933813118526 0.1769498741183268 0 0 0 0 K01431 0.0314285714285714 0.0512820512820512 UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6] path:map00240,path:map00410,path:map00770,path:map00983,path:map01100 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Drug metabolism - other enzymes,Metabolic pathways 243.0 34.0 33.0 2.0 0.971428571428571 S 14.0 21.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 35.0 0.4 0.6 0.229195565329953 0.627298878769027 0.42824722204949 0.398103313439074 0 0 0 0 K01432 0.0 0.0626780626780626 AFMID; arylformamidase [EC:3.5.1.9] path:map00380,path:map00630,path:map01100,path:map01240 Tryptophan metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of cofactors 213.0 26.0 0.0 1.0 1.0 I 0.0 26.0 1.0 1.0 COG0657 Acetyl_esterase/lipase Aes 26.0 0.0 1.0 0.0054758535697033 0.0261315560230007 0.015803704796352 0.0206557024532973 0 0 0 0 K01433 0.1485714285714285 0.3504273504273504 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] path:map00630,path:map00670,path:map01100 Glyoxylate and dicarboxylate metabolism,One carbon pool by folate,Metabolic pathways 215.0 198.0 197.0 2.0 0.994974874371859 F 55.0 144.0 2.0 0.994974874371859 COG0788 Formyltetrahydrofolate_hydrolase PurU 199.0 0.2763819095477386 0.7236180904522613 0.0160644505588556 0.0103495597663803 0.0132070051626179 0.0057148907924753 0 0 0 0 K01434 0.18 0.2763532763532763 pac; penicillin G amidase [EC:3.5.1.11] path:map00311,path:map01110 Penicillin and cephalosporin biosynthesis,Biosynthesis of secondary metabolites 238.0 194.0 185.0 6.0 0.902325581395349 S 80.0 135.0 2.0 0.986046511627907 COG2366 Acyl-homoserine_lactone_(AHL)_acylase_PvdQ PvdQ 215.0 0.3720930232558139 0.627906976744186 0.0610996606821374 0.650606090600202 0.3558528756411697 0.5895064299180646 0 0 0 0 K01436 0.06 0.4472934472934473 yhaA; amidohydrolase [EC:3.5.1.-] 227.0 135.0 38.0 3.0 0.569620253164557 S 23.0 214.0 2.0 0.911392405063291 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 237.0 0.0970464135021097 0.9029535864978904 0.0303095646029962 0.891494868509007 0.4609022165560016 0.8611853039060109 0 0 0 0 K01437 0.0 0.0284900284900284 ASPA, aspA; aspartoacylase [EC:3.5.1.15] path:map00250,path:map00340,path:map01100 Alanine, aspartate and glutamate metabolism,Histidine metabolism,Metabolic pathways 278.0 8.0 4.0 3.0 0.615384615384615 E 0.0 13.0 2.0 0.615384615384615 COG2988 Succinylglutamate_desuccinylase AstE 13.0 0.0 1.0 0.0162670445312078 0.0523434530193836 0.0343052487752957 0.0360764084881757 0 0 0 0 K01438 0.3714285714285714 0.3219373219373219 argE; acetylornithine deacetylase [EC:3.5.1.16] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 77.0 397.0 0.0 1.0 1.0 E 237.0 160.0 3.0 0.984886649874055 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 397.0 0.5969773299748111 0.4030226700251889 0.764081276844624 0.845775886592615 0.8049285817186196 0.081694609747991 1 1 1 1 K01439 0.5542857142857143 0.5441595441595442 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18] path:map00300,path:map01100,path:map01120,path:map01230 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of amino acids 65.0 596.0 593.0 3.0 0.993333333333333 E 337.0 263.0 4.0 0.991666666666667 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 600.0 0.5616666666666666 0.4383333333333333 0.135689337089882 0.743527404823907 0.4396083709568945 0.6078380677340249 0 0 0 0 K01440 0.0 0.0028490028490028 PNC1; nicotinamidase [EC:3.5.1.19] path:map00760,path:map01100,path:map01240,path:map04213 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors,Longevity regulating pathway - multiple species 349.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG1335 Nicotinamidase-related_amidase PncA 1.0 0.0 1.0 0 0 0 0 K01442 0.0542857142857142 0.1566951566951566 cbh; choloylglycine hydrolase [EC:3.5.1.24] path:map00120,path:map00121,path:map01100 Primary bile acid biosynthesis,Secondary bile acid biosynthesis,Metabolic pathways 84.0 101.0 100.0 2.0 0.990196078431373 M 24.0 78.0 3.0 0.980392156862745 COG3049 Penicillin_V_acylase_or_related_amidase,_Ntn_superfamily YxeI 102.0 0.2352941176470588 0.7647058823529411 0.0301276424720774 0.0306253089813048 0.0303764757266911 0.0004976665092274 0 0 0 0 K01443 0.0542857142857142 0.4928774928774929 nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 150.0 226.0 217.0 2.0 0.961702127659574 G 21.0 214.0 3.0 0.957446808510638 COG1820 N-acetylglucosamine-6-phosphate_deacetylase NagA 235.0 0.0893617021276595 0.9106382978723404 0.303681942938244 0.512390823973869 0.4080363834560565 0.208708881035625 0 0 0 0 K01444 0.0057142857142857 0.094017094017094 AGA, aspG; N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] path:map00511,path:map04142 Other glycan degradation,Lysosome 250.0 37.0 0.0 1.0 1.0 E 2.0 35.0 1.0 1.0 COG1446 Isoaspartyl_peptidase_or_L-asparaginase,_Ntn-hydrolase_superfamily IaaA 37.0 0.054054054054054 0.945945945945946 0.0850405265519175 0.564809183428044 0.3249248549899807 0.4797686568761264 0 0 0 0 K01446 0.0 0.0085470085470085 PGRP; peptidoglycan recognition protein path:map04624 Toll and Imd signaling pathway 161.0 2.0 1.0 2.0 0.666666666666667 G 0.0 3.0 2.0 0.666666666666667 COG3876 Uncharacterized_conserved_protein_YbbC,_DUF1343_family YbbC 3.0 0.0 1.0 0 0 0 0 K01447 0.0 0.3105413105413105 xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 14.0 82.0 35.0 6.0 0.535947712418301 V 0.0 148.0 17.0 0.542483660130719 COG3023 N-acetyl-anhydromuramyl-L-alanine_amidase_AmpD AmpD 148.0 0.0 1.0 0.0077402554599389 0.0771936425715126 0.0424669490157257 0.0694533871115737 0 0 0 0 K01448 0.0 0.0 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] path:map01503 Cationic antimicrobial peptide (CAMP) resistance 524.0 498.0 14.0 0.870431893687708 M 0.0 0.0 23.0 0.867430441898527 COG0860 N-acetylmuramoyl-L-alanine_amidase AmiC 0.0 0 0 0 0 K01449 0.0085714285714285 0.1139601139601139 cwlJ, sleB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 71.0 65.0 61.0 3.0 0.915492957746479 M 9.0 68.0 8.0 0.402597402597403 COG3773 Cell_wall_hydrolase_CwlJ,_involved_in_spore_germination CwlJ 77.0 0.1168831168831168 0.8831168831168831 0.0082448363459417 0.357983797592872 0.1831143169694068 0.3497389612469303 0 0 0 0 K01450 0.0028571428571428 0.0626780626780626 168.0 23.0 0.0 1.0 1.0 J 1.0 22.0 1.0 1.0 COG0242 Peptide_deformylase Def 23.0 0.0434782608695652 0.9565217391304348 0.0401006751315762 0.0921485111337971 0.0661245931326866 0.0520478360022209 0 0 0 0 K01451 0.0 0.0427350427350427 hipO; hippurate hydrolase [EC:3.5.1.32] path:map01100 Metabolic pathways 358.0 21.0 20.0 2.0 0.954545454545455 S 0.0 22.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 22.0 0.0 1.0 0.0135933631656219 0.0303873571608941 0.021990360163258 0.0167939939952721 0 0 0 0 K01452 0.0 0.0911680911680911 E3.5.1.41; chitin deacetylase [EC:3.5.1.41] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 268.0 36.0 0.0 1.0 1.0 G 0.0 36.0 2.0 0.972222222222222 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 36.0 0.0 1.0 0.31061757070836 0.124996970044122 0.2178072703762409 0.185620600664238 0 0 0 0 K01453 0.0 0.0028490028490028 nylB; 6-aminohexanoate-oligomer exohydrolase [EC:3.5.1.46] path:map00930,path:map01120 Caprolactam degradation,Microbial metabolism in diverse environments 388.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 1.0 0.0 1.0 0 0 0 0 K01455 0.0885714285714285 0.0883190883190883 E3.5.1.49; formamidase [EC:3.5.1.49] path:map00460,path:map00630,path:map00910,path:map01100,path:map01200 Cyanoamino acid metabolism,Glyoxylate and dicarboxylate metabolism,Nitrogen metabolism,Metabolic pathways,Carbon metabolism 214.0 69.0 61.0 2.0 0.896103896103896 C 37.0 40.0 2.0 0.896103896103896 COG2421 Acetamidase/formamidase FmdA 77.0 0.4805194805194805 0.5194805194805194 0.295958321603965 0.495861534691432 0.3959099281476985 0.199903213087467 0 0 0 0 K01456 0.0114285714285714 0.0 E3.5.1.52, NGLY1, PNG1; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52] path:map04141 Protein processing in endoplasmic reticulum 80.0 4.0 0.0 1.0 1.0 O 4.0 0.0 1.0 1.0 KOG0909 4.0 1.0 0.0 0.0887547034904862 0.16760467213459 0.128179687812538 0.0788499686441037 0 0 0 0 K01457 0.0 0.1396011396011396 atzF; allophanate hydrolase [EC:3.5.1.54] path:map00220,path:map00791,path:map01100,path:map01120 Arginine biosynthesis,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 72.0 39.0 4.0 2.0 0.527027027027027 E 0.0 74.0 3.0 0.472972972972973 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 74.0 0.0 1.0 0.010755510764874 0.0410816832101458 0.0259185969875099 0.0303261724452717 0 0 0 0 K01458 0.0057142857142857 0.1025641025641025 hutG; N-formylglutamate deformylase [EC:3.5.1.68] path:map00340,path:map00630,path:map01100 Histidine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways 189.0 43.0 0.0 1.0 1.0 E 2.0 41.0 2.0 0.953488372093023 COG3741 N-formylglutamate_amidohydrolase HutG 43.0 0.0465116279069767 0.9534883720930232 0.0061319117651635 0.0335779753220891 0.0198549435436263 0.0274460635569256 0 0 0 0 K01459 0.0 0.0341880341880341 E3.5.1.77; N-carbamoyl-D-amino-acid hydrolase [EC:3.5.1.77] 267.0 7.0 3.0 3.0 0.538461538461538 S 0.0 13.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 13.0 0.0 1.0 0.066765638390722 0.667107800275858 0.36693671933329 0.600342161885136 0 0 0 0 K01460 0.0 0.017094017094017 gsp; glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 264.0 4.0 2.0 2.0 0.666666666666667 E 0.0 6.0 3.0 0.666666666666667 COG0754 Glutathionylspermidine_synthase,_CHAP_domain Gsp 6.0 0.0 1.0 0.0906019135551341 0.228004806881192 0.159303360218163 0.1374028933260579 0 0 0 0 K01461 0.0 0.0056980056980056 E3.5.1.82; N-acyl-D-glutamate deacylase [EC:3.5.1.82] 438.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG3653 N-acyl-D-aspartate/D-glutamate_deacylase 2.0 0.0 1.0 0 0 0 0 K01462 0.02 0.9544159544159544 PDF, def; peptide deformylase [EC:3.5.1.88] 55.0 490.0 0.0 1.0 1.0 J 9.0 482.0 1.0 1.0 COG0242 Peptide_deformylase Def 491.0 0.0183299389002036 0.9816700610997964 0.112087315399321 0.456444628513578 0.2842659719564495 0.344357313114257 0 0 0 0 K01463 0.0742857142857142 0.1965811965811965 bshB1; N-acetylglucosamine malate deacetylase 1 [EC:3.5.1.-] 117.0 110.0 107.0 2.0 0.973451327433628 S 32.0 81.0 2.0 0.991150442477876 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 113.0 0.2831858407079646 0.7168141592920354 0.0078200247580309 0.0327549906296544 0.0202875076938426 0.0249349658716235 0 0 0 0 K01464 0.1857142857142857 0.2222222222222222 DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2] path:map00240,path:map00410,path:map00770,path:map00983,path:map01100 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Drug metabolism - other enzymes,Metabolic pathways 248.0 184.0 0.0 1.0 1.0 F 87.0 97.0 1.0 1.0 COG0044 Dihydroorotase_or_related_cyclic_amidohydrolase AllB 184.0 0.4728260869565217 0.5271739130434783 0.928523741894156 0.99074455894845 0.9596341504213032 0.062220817054294 1 1 1 1 K01465 0.6885714285714286 0.8575498575498576 URA4, pyrC; dihydroorotase [EC:3.5.2.3] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 89.0 657.0 617.0 7.0 0.917597765363128 F 259.0 457.0 7.0 0.83659217877095 COG0044 Dihydroorotase_or_related_cyclic_amidohydrolase AllB 716.0 0.361731843575419 0.638268156424581 0.687456696846338 0.437697102374596 0.562576899610467 0.249759594471742 0 1 0 1 K01466 0.2142857142857142 0.1623931623931624 allB; allantoinase [EC:3.5.2.5] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 274.0 151.0 0.0 1.0 1.0 F 83.0 68.0 1.0 1.0 COG0044 Dihydroorotase_or_related_cyclic_amidohydrolase AllB 151.0 0.5496688741721855 0.4503311258278146 0.756893332048819 0.97096951512783 0.8639314235883245 0.214076183079011 1 1 1 1 K01467 0.0028571428571428 0.0712250712250712 ampC; beta-lactamase class C [EC:3.5.2.6] path:map01501,path:map02020 beta-Lactam resistance,Two-component system 128.0 29.0 0.0 1.0 1.0 V 1.0 28.0 2.0 0.793103448275862 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 29.0 0.0344827586206896 0.9655172413793104 0.0627857696095198 0.233391138650987 0.1480884541302534 0.1706053690414672 0 0 0 0 K01468 0.2142857142857142 0.4017094017094017 hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 274.0 141.0 52.0 2.0 0.61304347826087 Q 83.0 147.0 1.0 1.0 COG1228 Imidazolonepropionase_or_related_amidohydrolase HutI 230.0 0.3608695652173913 0.6391304347826087 0.465717526270666 0.172505826262856 0.3191116762667609 0.29321170000781 0 0 0 0 K01469 0.0771428571428571 0.1709401709401709 OPLAH, OXP1, oplAH; 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 424.0 81.0 54.0 2.0 0.75 EQ 30.0 71.0 2.0 0.944444444444444 COG0145 N-methylhydantoinase_A/oxoprolinase/acetone_carboxylase,_beta_subunit HyuA 101.0 0.297029702970297 0.7029702970297029 0.244350212180938 0.399801115180424 0.3220756636806809 0.155450902999486 0 0 0 0 K01470 0.3942857142857143 0.3048433048433048 E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 49.0 205.0 12.0 4.0 0.465909090909091 H 264.0 176.0 2.0 0.995454545454546 COG1402 Creatinine_amidohydrolase/Fe(II)-dependent_FAPy_formamide_hydrolase_(riboflavin_and_F420_biosynthesis) ArfB 440.0 0.6 0.4 0.273854776313322 0.211983754271586 0.242919265292454 0.061871022041736 0 0 0 0 K01473 0.2657142857142857 0.1965811965811965 hyuA; N-methylhydantoinase A [EC:3.5.2.14] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 355.0 165.0 54.0 2.0 0.597826086956522 EQ 126.0 150.0 1.0 1.0 COG0145 N-methylhydantoinase_A/oxoprolinase/acetone_carboxylase,_beta_subunit HyuA 276.0 0.4565217391304347 0.5434782608695652 0.202285489611614 0.341130053411128 0.271707771511371 0.138844563799514 0 0 0 0 K01474 0.2685714285714285 0.1994301994301994 hyuB; N-methylhydantoinase B [EC:3.5.2.14] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 312.0 157.0 48.0 2.0 0.590225563909774 EQ 126.0 140.0 2.0 0.996240601503759 COG0146 N-methylhydantoinase_B/oxoprolinase/acetone_carboxylase,_alpha_subunit HyuB 266.0 0.4736842105263157 0.5263157894736842 0.324676354502143 0.734602731679191 0.529639543090667 0.409926377177048 0 0 0 0 K01476 0.2314285714285714 0.2364672364672364 E3.5.3.1, rocF, arg; arginase [EC:3.5.3.1] path:map00220,path:map00330,path:map01100,path:map01110,path:map01230,path:map05146 Arginine biosynthesis,Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Amoebiasis 146.0 199.0 0.0 1.0 1.0 E 98.0 101.0 1.0 1.0 COG0010 Arginase/agmatinase_family_enzyme SpeB 199.0 0.4924623115577889 0.507537688442211 0.30691205623007 0.879341546821619 0.5931268015258445 0.572429490591549 0 0 0 0 K01477 0.0028571428571428 0.0655270655270655 alc, ALLC; allantoicase [EC:3.5.3.4] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 287.0 25.0 24.0 2.0 0.961538461538462 F 1.0 25.0 2.0 0.923076923076923 COG4266 Allantoicase Alc 26.0 0.0384615384615384 0.9615384615384616 0.0500729540411345 0.11952258371577 0.0847977688784522 0.0694496296746355 0 0 0 0 K01478 0.12 0.1709401709401709 arcA; arginine deiminase [EC:3.5.3.6] path:map00220,path:map01100,path:map01110 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 174.0 131.0 0.0 1.0 1.0 E 57.0 74.0 2.0 0.824427480916031 COG2235 Arginine_deiminase ArcA 131.0 0.4351145038167939 0.5648854961832062 0.029014643788011 0.20600758395339 0.1175111138707005 0.176992940165379 0 0 0 0 K01479 0.0971428571428571 0.2165242165242165 hutG; formiminoglutamase [EC:3.5.3.8] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 80.0 133.0 132.0 2.0 0.992537313432836 E 35.0 99.0 2.0 0.798507462686567 COG0010 Arginase/agmatinase_family_enzyme SpeB 134.0 0.2611940298507462 0.7388059701492538 0.181760079191326 0.453270972509237 0.3175155258502815 0.271510893317911 0 0 0 0 K01480 0.8457142857142858 0.49002849002849 speB; agmatinase [EC:3.5.3.11] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 35.0 633.0 632.0 2.0 0.998422712933754 E 386.0 247.0 1.0 1.0 COG0010 Arginase/agmatinase_family_enzyme SpeB 633.0 0.6097946287519748 0.3902053712480253 0.0953126374943689 0.564530995115317 0.3299218163048429 0.4692183576209481 0 0 0 0 K01481 0.0 0.0227920227920227 E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15] 200.0 8.0 0.0 1.0 1.0 L 0.0 8.0 1.0 1.0 COG1193 dsDNA-specific_endonuclease/ATPase_MutS2 MutS2 8.0 0.0 1.0 0.942605034318083 0.363551333961917 0.65307818414 0.579053700356166 0 0 1 1 K01482 0.0914285714285714 0.0712250712250712 DDAH, ddaH; dimethylargininase [EC:3.5.3.18] 174.0 63.0 61.0 4.0 0.940298507462687 E 39.0 28.0 2.0 0.955223880597015 COG1834 N-Dimethylarginine_dimethylaminohydrolase DdaH 67.0 0.582089552238806 0.417910447761194 0.848240935246513 0.976640095223357 0.9124405152349352 0.128399159976844 1 1 1 1 K01483 0.0 0.0626780626780626 allA; ureidoglycolate lyase [EC:4.3.2.3] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 137.0 25.0 0.0 1.0 1.0 F 0.0 25.0 1.0 1.0 COG3194 Ureidoglycolate_hydrolase_(allantoin_degradation) AllA 25.0 0.0 1.0 0.0415698429600675 0.051338188114549 0.0464540155373082 0.0097683451544815 0 0 0 0 K01484 0.0 0.0598290598290598 astB; succinylarginine dihydrolase [EC:3.5.3.23] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 410.0 21.0 0.0 1.0 1.0 E 0.0 21.0 1.0 1.0 COG3724 Succinylarginine_dihydrolase AstB 21.0 0.0 1.0 0.0157829612067855 0.0394184271117656 0.0276006941592755 0.0236354659049801 0 0 0 0 K01485 0.2685714285714285 0.3361823361823361 codA; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] path:map00240,path:map00330,path:map01100,path:map01232 Pyrimidine metabolism,Arginine and proline metabolism,Metabolic pathways,Nucleotide metabolism 30.0 180.0 74.0 4.0 0.578778135048232 F 143.0 168.0 4.0 0.488745980707396 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 311.0 0.4598070739549839 0.5401929260450161 0.0161990595666681 0.0928398442816292 0.0545194519241486 0.0766407847149611 0 0 0 0 K01486 0.2685714285714285 0.2934472934472934 ade; adenine deaminase [EC:3.5.4.2] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 324.0 236.0 233.0 2.0 0.98744769874477 F 109.0 132.0 4.0 0.979253112033195 COG1001 Adenine_deaminase AdeC 241.0 0.4522821576763485 0.5477178423236515 0.590424987000409 0.987763058383344 0.7890940226918766 0.397338071382935 0 1 0 1 K01487 0.16 0.2877492877492877 guaD, GDA; guanine deaminase [EC:3.5.4.3] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 55.0 127.0 53.0 2.0 0.6318407960199 F 77.0 128.0 3.0 0.604878048780488 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 205.0 0.375609756097561 0.624390243902439 0.0313285718898248 0.234434623255436 0.1328815975726304 0.2031060513656112 0 0 0 0 K01488 0.0314285714285714 0.358974358974359 add, ADA; adenosine deaminase [EC:3.5.4.4] path:map00230,path:map01100,path:map01232,path:map05340 Purine metabolism,Metabolic pathways,Nucleotide metabolism,Primary immunodeficiency 151.0 207.0 197.0 2.0 0.953917050691244 F 11.0 206.0 3.0 0.944700460829493 COG1816 Adenosine_deaminase Add 217.0 0.0506912442396313 0.9493087557603688 0.083543429076109 0.751419529686107 0.417481479381108 0.667876100609998 0 0 0 0 K01489 0.2257142857142857 0.6267806267806267 cdd, CDA; cytidine deaminase [EC:3.5.4.5] path:map00240,path:map00983,path:map01100,path:map01232 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 35.0 295.0 272.0 5.0 0.838068181818182 F 86.0 273.0 6.0 0.799442896935933 COG0295 Cytidine_deaminase Cdd 359.0 0.2395543175487465 0.7604456824512534 0.142810179126192 0.236156526773458 0.189483352949825 0.0933463476472659 0 0 0 0 K01491 0.4485714285714285 0.96011396011396 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] path:map00670,path:map00720,path:map01100,path:map01120,path:map01200,path:map01240 One carbon pool by folate,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of cofactors 198.0 401.0 284.0 4.0 0.743970315398887 F 165.0 374.0 3.0 0.805194805194805 COG0190 5,10-methylene-tetrahydrofolate_dehydrogenase/Methenyl_tetrahydrofolate_cyclohydrolase FolD 539.0 0.3061224489795918 0.6938775510204082 0.238801968248645 0.424660053620876 0.3317310109347605 0.185858085372231 0 0 0 0 K01492 0.1485714285714285 0.0 purNH; phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3] path:map00230,path:map00670,path:map01100,path:map01110 Purine metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites 449.0 52.0 0.0 1.0 1.0 F 52.0 0.0 1.0 1.0 COG0138 AICAR_transformylase/IMP_cyclohydrolase_PurH PurH 52.0 1.0 0.0 0.37748875531517 0.0142338652072437 0.1958613102612068 0.3632548901079263 0 0 0 0 K01493 0.48 0.4786324786324786 comEB; dCMP deaminase [EC:3.5.4.12] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 50.0 346.0 341.0 3.0 0.980169971671388 F 178.0 175.0 4.0 0.968838526912181 COG2131 Deoxycytidylate_deaminase ComEB 353.0 0.5042492917847026 0.4957507082152974 0.545310269597993 0.582200567622073 0.563755418610033 0.0368902980240799 0 1 0 1 K01494 0.5971428571428572 0.5156695156695157 dcd; dCTP deaminase [EC:3.5.4.13] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 32.0 479.0 473.0 3.0 0.98559670781893 F 288.0 198.0 5.0 0.983539094650206 COG0717 dCTP_deaminase Dcd 486.0 0.5925925925925926 0.4074074074074074 0.0488251872948218 0.243742285038085 0.1462837361664534 0.1949170977432632 0 0 0 0 K01495 0.1657142857142857 0.6467236467236467 GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 110.0 281.0 229.0 3.0 0.828908554572271 H 59.0 280.0 3.0 0.958702064896755 COG0302 GTP_cyclohydrolase_I FolE 339.0 0.1740412979351032 0.8259587020648967 0.0140480041033693 0.153921692311239 0.0839848482073041 0.1398736882078697 0 0 0 0 K01496 0.4457142857142857 0.5669515669515669 hisI; phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 69.0 365.0 359.0 2.0 0.983827493261455 E 160.0 207.0 3.0 0.975741239892183 COG0139 Phosphoribosyl-AMP_cyclohydrolase HisI1 367.0 0.4359673024523161 0.5640326975476839 0.410916938340725 0.459861303623931 0.435389120982328 0.048944365283206 0 0 0 0 K01497 0.0971428571428571 0.2279202279202279 ribA, RIB1; GTP cyclohydrolase II [EC:3.5.4.25] path:map00740,path:map00790,path:map01100,path:map01110,path:map01240,path:map02024 Riboflavin metabolism,Folate biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Quorum sensing 148.0 99.0 83.0 3.0 0.7734375 H 41.0 87.0 4.0 0.8515625 COG0807 GTP_cyclohydrolase_II RibA 128.0 0.3203125 0.6796875 0.282373915848608 0.368759632033242 0.325566773940925 0.086385716184634 0 0 0 0 K01498 0.0 0.0427350427350427 ribD1; diaminohydroxyphosphoribosylaminopyrimidine deaminase [EC:3.5.4.26] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 328.0 15.0 0.0 1.0 1.0 H 0.0 15.0 1.0 1.0 COG0117 Riboflavin_biosynthesis_protein_RibD,_pyrimidine_deaminase_domain RibD1 15.0 0.0 1.0 0.0286169732586733 0.145606946611081 0.0871119599348771 0.1169899733524077 0 0 0 0 K01499 0.3742857142857143 0.037037037037037 mch; methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 250.0 158.0 0.0 1.0 1.0 H 145.0 13.0 1.0 1.0 COG3252 Methenyltetrahydromethanopterin_cyclohydrolase Mch 158.0 0.9177215189873418 0.0822784810126582 0.940103257180109 0.904189560250498 0.9221464087153036 0.0359136969296109 1 1 1 1 K01501 0.0228571428571428 0.1339031339031339 E3.5.5.1; nitrilase [EC:3.5.5.1] path:map00380,path:map00460,path:map00627,path:map00643,path:map00910,path:map01100,path:map01120 Tryptophan metabolism,Cyanoamino acid metabolism,Aminobenzoate degradation,Styrene degradation,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 173.0 56.0 53.0 2.0 0.949152542372881 S 10.0 49.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 59.0 0.1694915254237288 0.8305084745762712 0.111862982444507 0.953324218271551 0.532593600358029 0.841461235827044 0 0 0 0 K01502 0.0028571428571428 0.0284900284900284 E3.5.5.7; aliphatic nitrilase [EC:3.5.5.7] path:map00643,path:map01120 Styrene degradation,Microbial metabolism in diverse environments 309.0 11.0 0.0 1.0 1.0 S 1.0 10.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 11.0 0.0909090909090909 0.9090909090909092 0.0596402243167619 0.203961144815322 0.1318006845660419 0.1443209204985601 0 0 0 0 K01505 0.02 0.1367521367521367 E3.5.99.7; 1-aminocyclopropane-1-carboxylate deaminase [EC:3.5.99.7] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 187.0 59.0 0.0 1.0 1.0 E 7.0 52.0 1.0 1.0 COG2515 1-aminocyclopropane-1-carboxylate_deaminase/D-cysteine_desulfhydrase,_PLP-dependent_ACC_family Acd 59.0 0.1186440677966101 0.8813559322033898 0.0245252611114516 0.085642627277735 0.0550839441945933 0.0611173661662833 0 0 0 0 K01507 0.4571428571428571 0.5498575498575499 ppa; inorganic pyrophosphatase [EC:3.6.1.1] path:map00190 Oxidative phosphorylation 93.0 381.0 380.0 2.0 0.99738219895288 C 172.0 215.0 6.0 0.930232558139535 COG0221 Inorganic_pyrophosphatase Ppa 387.0 0.4444444444444444 0.5555555555555556 0.0402328063816029 0.32637775908438 0.1833052827329914 0.286144952702777 0 0 0 0 K01512 0.6571428571428571 0.5441595441595442 acyP; acylphosphatase [EC:3.6.1.7] path:map00620,path:map00627,path:map01100,path:map01120 Pyruvate metabolism,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 36.0 443.0 431.0 3.0 0.971491228070175 C 262.0 193.0 3.0 0.971491228070175 COG1254 Acylphosphatase AcyP 455.0 0.5758241758241758 0.4241758241758241 0.577707341737845 0.681703338271637 0.629705340004741 0.1039959965337919 0 1 0 1 K01514 0.0 0.0028490028490028 PRUNE, PPX1; exopolyphosphatase [EC:3.6.1.11] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 308.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1227 Inorganic_pyrophosphatase/exopolyphosphatase PPX1 1.0 0.0 1.0 0 0 0 0 K01515 0.0 0.0 nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13 3.6.1.-] path:map00230,path:map00740,path:map01100 Purine metabolism,Riboflavin metabolism,Metabolic pathways 519.0 461.0 4.0 0.89328743545611 L 0.0 0.0 4.0 0.820998278829604 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 0.0 0 0 0 0 K01518 0.1142857142857142 0.0427350427350427 NUDT2; bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17] path:map00230,path:map00240,path:map01100 Purine metabolism,Pyrimidine metabolism,Metabolic pathways 41.0 22.0 4.0 4.0 0.392857142857143 F 41.0 15.0 2.0 0.642857142857143 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 56.0 0.7321428571428571 0.2678571428571428 0.822197653944737 0.968070723225121 0.895134188584929 0.145873069280384 1 1 1 1 K01519 0.0114285714285714 0.0028490028490028 rdgB, ITPA; XTP/dITP diphosphohydrolase [EC:3.6.1.66] path:map00230,path:map00983,path:map01100,path:map01232 Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 170.0 5.0 0.0 1.0 1.0 F 4.0 1.0 1.0 1.0 COG0127 Inosine/xanthosine_triphosphate_pyrophosphatase,_all-alpha_NTP-PPase_family RdgB 5.0 0.8 0.2 0.0626319041454574 0.445370062290897 0.2540009832181772 0.3827381581454396 0 0 0 0 K01520 0.4828571428571429 0.6780626780626781 dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] path:map00240,path:map00983,path:map01100,path:map01232 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 57.0 427.0 0.0 1.0 1.0 F 176.0 251.0 2.0 0.690866510538642 COG0756 dUTP_pyrophosphatase_(dUTPase) Dut 427.0 0.4121779859484777 0.5878220140515222 0.0344139303362641 0.0565557173602347 0.0454848238482494 0.0221417870239706 0 0 0 0 K01521 0.0 0.017094017094017 cdh; CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 214.0 6.0 0.0 1.0 1.0 I 0.0 6.0 1.0 1.0 COG2134 CDP-diacylglycerol_pyrophosphatase Cdh 6.0 0.0 1.0 0.018090273609956 0.10444156708993 0.061265920349943 0.086351293479974 0 0 0 0 K01522 0.0028571428571428 0.0 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29] path:map00230,path:map01100,path:map05222,path:map05223 Purine metabolism,Metabolic pathways,Small cell lung cancer,Non-small cell lung cancer 143.0 1.0 0.0 1.0 1.0 F 1.0 0.0 1.0 1.0 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 1.0 1.0 0.0 0 0 0 0 K01523 0.2742857142857143 0.2649572649572649 hisE; phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 78.0 183.0 172.0 2.0 0.943298969072165 E 97.0 97.0 2.0 0.969072164948454 COG0140 Phosphoribosyl-ATP_pyrophosphohydrolase HisI2 194.0 0.5 0.5 0.120178742930124 0.0059927712617783 0.0630857570959511 0.1141859716683457 0 0 0 0 K01524 0.12 0.6609686609686609 ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 69.0 331.0 290.0 8.0 0.801452784503632 FP 53.0 356.0 13.0 0.88861985472155 COG0248 Exopolyphosphatase/pppGpp-phosphohydrolase GppA 409.0 0.1295843520782396 0.8704156479217604 0.0090154030116114 0.114149252935773 0.0615823279736921 0.1051338499241616 0 0 0 0 K01525 0.0 0.0997150997150997 apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 220.0 35.0 0.0 1.0 1.0 T 0.0 35.0 1.0 1.0 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 35.0 0.0 1.0 0.0009146089313426 0.0018048920957013 0.0013597505135219 0.0008902831643587 0 0 0 0 K01531 0.1028571428571428 0.1737891737891738 mgtA, mgtB; P-type Mg2+ transporter [EC:7.2.2.14] 428.0 139.0 134.0 2.0 0.965277777777778 P 45.0 84.0 2.0 0.965277777777778 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 129.0 0.3488372093023256 0.6511627906976745 0.121265329860164 0.864353811664316 0.49280957076224 0.743088481804152 0 0 0 0 K01533 0.4942857142857143 0.6153846153846154 copB; P-type Cu2+ transporter [EC:7.2.2.9] 335.0 649.0 615.0 2.0 0.950219619326501 P 320.0 361.0 6.0 0.898975109809663 COG2217 Cation-transporting_P-type_ATPase ZntA 681.0 0.4698972099853157 0.5301027900146843 0.0033838653258626 0.436896088239188 0.2201399767825253 0.4335122229133254 0 0 0 0 K01534 0.3571428571428571 0.50997150997151 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] 437.0 453.0 442.0 3.0 0.970021413276231 P 180.0 287.0 6.0 0.940042826552462 COG2217 Cation-transporting_P-type_ATPase ZntA 467.0 0.3854389721627409 0.6145610278372591 0.519916762962517 0.760458258384192 0.6401875106733546 0.240541495421675 0 1 0 1 K01535 0.1485714285714285 0.094017094017094 PMA1, PMA2; H+-transporting ATPase [EC:7.1.2.1] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 548.0 112.0 0.0 1.0 1.0 P 70.0 42.0 1.0 1.0 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 112.0 0.625 0.375 0.0826568754020734 0.238937219806808 0.1607970476044407 0.1562803444047346 0 0 0 0 K01537 0.5514285714285714 0.5356125356125356 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10] 491.0 596.0 0.0 1.0 1.0 P 288.0 308.0 2.0 0.996644295302013 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 596.0 0.4832214765100671 0.5167785234899329 0.406591171420972 0.917322429672233 0.6619568005466026 0.510731258251261 0 0 0 0 K01539 0.0457142857142857 0.0199430199430199 ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] path:map04022,path:map04024,path:map04260,path:map04261,path:map04911,path:map04918,path:map04919,path:map04925,path:map04960,path:map04961,path:map04964,path:map04970,path:map04971,path:map04972,path:map04973,path:map04974,path:map04976,path:map04978 cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Insulin secretion,Thyroid hormone synthesis,Thyroid hormone signaling pathway,Aldosterone synthesis and secretion,Aldosterone-regulated sodium reabsorption,Endocrine and other factor-regulated calcium reabsorption,Proximal tubule bicarbonate reclamation,Salivary secretion,Gastric acid secretion,Pancreatic secretion,Carbohydrate digestion and absorption,Protein digestion and absorption,Bile secretion,Mineral absorption 817.0 25.0 0.0 1.0 1.0 P 18.0 7.0 1.0 1.0 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 25.0 0.72 0.28 0.0364513034738983 0.0544725147528792 0.0454619091133887 0.0180212112789809 0 0 0 0 K01541 0.0 0.0056980056980056 675.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 2.0 0.0 1.0 0 0 0 0 K01546 0.0771428571428571 0.2478632478632478 kdpA; potassium-transporting ATPase potassium-binding subunit path:map02020 Two-component system 480.0 128.0 127.0 2.0 0.992248062015504 P 31.0 98.0 2.0 0.976744186046512 COG2060 K+-transporting_ATPase,_KdpA_subunit KdpA 129.0 0.2403100775193798 0.7596899224806202 0.0102777439746445 0.639433488989751 0.3248556164821978 0.6291557450151065 0 0 0 0 K01547 0.0771428571428571 0.2478632478632478 kdpB; potassium-transporting ATPase ATP-binding subunit [EC:7.2.2.6] path:map02020 Two-component system 600.0 122.0 0.0 1.0 1.0 P 28.0 94.0 1.0 1.0 COG2216 K+_transport_ATPase,_ATPase_subunit_KdpB KdpB 122.0 0.2295081967213114 0.7704918032786885 0.0310738366234294 0.74878602310275 0.3899299298630897 0.7177121864793206 0 0 0 0 K01548 0.0714285714285714 0.2507122507122507 kdpC; potassium-transporting ATPase KdpC subunit path:map02020 Two-component system 124.0 119.0 0.0 1.0 1.0 P 25.0 94.0 1.0 1.0 COG2156 K+-transporting_ATPase,_KdpC_subunit KdpC 119.0 0.2100840336134453 0.7899159663865546 0.026129305151312 0.642580496632857 0.3343549008920845 0.616451191481545 0 0 0 0 K01551 0.4171428571428571 0.2934472934472934 arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-] 131.0 217.0 53.0 4.0 0.562176165803109 D 230.0 155.0 2.0 0.989637305699482 COG0003 Anion-transporting_ATPase,_ArsA/GET3_family ArsA 385.0 0.5974025974025974 0.4025974025974026 0.0291543322439824 0.916582217339489 0.4728682747917357 0.8874278850955065 0 0 0 0 K01555 0.0057142857142857 0.150997150997151 FAH, fahA; fumarylacetoacetase [EC:3.7.1.2] path:map00350,path:map00643,path:map01100,path:map01120 Tyrosine metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 353.0 59.0 0.0 1.0 1.0 Q 2.0 57.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 59.0 0.0338983050847457 0.9661016949152542 0.0022460915407221 0.0149707909233919 0.008608441232057 0.0127246993826698 0 0 0 0 K01556 0.0742857142857142 0.2079772079772079 KYNU, kynU; kynureninase [EC:3.7.1.3] path:map00380,path:map01100,path:map01240 Tryptophan metabolism,Metabolic pathways,Biosynthesis of cofactors 293.0 96.0 92.0 3.0 0.923076923076923 E 28.0 76.0 2.0 0.701923076923077 COG3844 Kynureninase Bna5 104.0 0.2692307692307692 0.7307692307692307 0.575088129164458 0.887823272041645 0.7314557006030515 0.312735142877187 0 1 0 1 K01560 0.2714285714285714 0.3618233618233618 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2] path:map00361,path:map00625,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 33.0 310.0 308.0 3.0 0.990415335463259 S 138.0 175.0 4.0 0.907348242811502 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 313.0 0.4408945686900958 0.5591054313099042 0.241615951740789 0.826363763079413 0.533989857410101 0.584747811338624 0 0 0 0 K01561 0.0542857142857142 0.1139601139601139 dehH; haloacetate dehalogenase [EC:3.8.1.3] path:map00361,path:map00625,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 98.0 64.0 62.0 2.0 0.96969696969697 S 21.0 45.0 3.0 0.651515151515152 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 66.0 0.3181818181818182 0.6818181818181818 0.0203002249657299 0.799442456435985 0.4098713407008574 0.7791422314702551 0 0 0 0 K01563 0.0485714285714285 0.1737891737891738 dhaA; haloalkane dehalogenase [EC:3.8.1.5] path:map00361,path:map00625,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 104.0 69.0 45.0 4.0 0.644859813084112 S 20.0 86.0 5.0 0.607476635514019 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 106.0 0.1886792452830188 0.8113207547169812 0.21307764983494 0.922772511968095 0.5679250809015175 0.7096948621331549 0 0 0 0 K01565 0.0 0.0227920227920227 SGSH; N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1] path:map00531,path:map01100,path:map04142 Glycosaminoglycan degradation,Metabolic pathways,Lysosome 383.0 16.0 0.0 1.0 1.0 P 0.0 16.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 16.0 0.0 1.0 0.0152417697391293 0.0286671073978199 0.0219544385684746 0.0134253376586906 0 0 0 0 K01567 0.0 0.0512820512820512 pdaA; peptidoglycan-N-acetylmuramic acid deacetylase [EC:3.5.1.-] 182.0 26.0 0.0 1.0 1.0 G 0.0 26.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 26.0 0.0 1.0 0.0372140752208215 0.0217274245314818 0.0294707498761516 0.0154866506893396 0 0 0 0 K01568 0.0 0.0199430199430199 PDC, pdc; pyruvate decarboxylase [EC:4.1.1.1] path:map00010,path:map01100,path:map01110 Glycolysis / Gluconeogenesis,Metabolic pathways,Biosynthesis of secondary metabolites 530.0 4.0 1.0 2.0 0.571428571428571 GH 0.0 7.0 1.0 1.0 COG3961 TPP-dependent_2-oxoacid_decarboxylase,_includes_indolepyruvate_decarboxylase PDC1 7.0 0.0 1.0 0.115546644745516 0.255032487774094 0.185289566259805 0.1394858430285779 0 0 0 0 K01569 0.0028571428571428 0.037037037037037 oxdD; oxalate decarboxylase [EC:4.1.1.2] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 297.0 20.0 0.0 1.0 1.0 G 2.0 18.0 1.0 1.0 COG2140 Oxalate_decarboxylase/archaeal_phosphoglucose_isomerase,_cupin_superfamily OxdD 20.0 0.1 0.9 0.0171275261274808 0.0386820853951968 0.0279048057613388 0.0215545592677159 0 0 0 0 K01571 0.0571428571428571 0.2621082621082621 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 51.0 74.0 47.0 3.0 0.582677165354331 C 21.0 103.0 3.0 0.535433070866142 COG0511 Biotin_carboxyl_carrier_protein AccB 124.0 0.1693548387096774 0.8306451612903226 0.348111443091889 0.658101261410616 0.5031063522512524 0.3099898183187269 0 0 0 0 K01572 0.0571428571428571 0.2336182336182336 329.0 128.0 125.0 2.0 0.977099236641221 C 21.0 110.0 3.0 0.977099236641221 COG1883 Na+-transporting_oxaloacetate/methylmalonyl-CoA_decarboxylase,_beta_subunit OadB 131.0 0.1603053435114503 0.8396946564885496 0.709825698976299 0.38679357943769 0.5483096392069945 0.323032119538609 0 1 0 1 K01573 0.0 0.0683760683760683 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 46.0 22.0 19.0 2.0 0.88 C 0.0 25.0 5.0 0.8 COG3630 Na+-transporting_oxaloacetate/methylmalonyl-CoA_decarboxylase,_gamma_subunit OadG 25.0 0.0 1.0 0.0927544029361145 0.0222744278187131 0.0575144153774138 0.0704799751174014 0 0 0 0 K01574 0.0285714285714285 0.0569800569800569 adc; acetoacetate decarboxylase [EC:4.1.1.4] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 122.0 35.0 29.0 2.0 0.853658536585366 Q 16.0 27.0 3.0 0.813953488372093 COG4689 Acetoacetate_decarboxylase Adc 43.0 0.3720930232558139 0.627906976744186 0.0024481913905693 0.0106501118516033 0.0065491516210863 0.008201920461034 0 0 0 0 K01575 0.0714285714285714 0.0683760683760683 alsD, budA, aldC; acetolactate decarboxylase [EC:4.1.1.5] path:map00650,path:map00660,path:map01110 Butanoate metabolism,C5-Branched dibasic acid metabolism,Biosynthesis of secondary metabolites 160.0 48.0 42.0 2.0 0.888888888888889 Q 27.0 27.0 2.0 0.981481481481482 COG3527 Alpha-acetolactate_decarboxylase AlsD 54.0 0.5 0.5 0.004695418924603 0.0172318060123316 0.0109636124684673 0.0125363870877286 0 0 0 0 K01576 0.0942857142857142 0.0968660968660968 mdlC; benzoylformate decarboxylase [EC:4.1.1.7] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 336.0 49.0 8.0 3.0 0.515789473684211 EH 46.0 49.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 95.0 0.4842105263157895 0.5157894736842106 0.0046758432217281 0.0157246702475857 0.0102002567346569 0.0110488270258576 0 0 0 0 K01577 0.0 0.0341880341880341 oxc; oxalyl-CoA decarboxylase [EC:4.1.1.8] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 456.0 14.0 13.0 2.0 0.933333333333333 EH 0.0 15.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 15.0 0.0 1.0 0.0684156630523903 0.182082063729223 0.1252488633908066 0.1136664006768327 0 0 0 0 K01578 0.0 0.0598290598290598 MLYCD; malonyl-CoA decarboxylase [EC:4.1.1.9] path:map00410,path:map00640,path:map01100,path:map04146,path:map04152,path:map04936 beta-Alanine metabolism,Propanoate metabolism,Metabolic pathways,Peroxisome,AMPK signaling pathway,Alcoholic liver disease 391.0 23.0 0.0 1.0 1.0 G 0.0 23.0 1.0 1.0 COG1593 TRAP-type_C4-dicarboxylate_transport_system,_large_permease_component DctQ 23.0 0.0 1.0 0.0251493488012454 0.369554595059591 0.1973519719304182 0.3444052462583455 0 0 0 0 K01579 0.0714285714285714 0.5498575498575499 panD; aspartate 1-decarboxylase [EC:4.1.1.11] path:map00410,path:map00770,path:map01100,path:map01110,path:map01240 beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 102.0 224.0 0.0 1.0 1.0 H 25.0 199.0 1.0 1.0 COG0853 Aspartate_1-decarboxylase PanD 224.0 0.1116071428571428 0.8883928571428571 0.1022381505229 0.289129401883772 0.195683776203336 0.186891251360872 0 0 0 0 K01580 0.04 0.1054131054131054 E4.1.1.15, gadB, gadA, GAD; glutamate decarboxylase [EC:4.1.1.15] path:map00250,path:map00410,path:map00430,path:map00650,path:map01100,path:map01110,path:map01120,path:map02024,path:map04727,path:map04940 Alanine, aspartate and glutamate metabolism,beta-Alanine metabolism,Taurine and hypotaurine metabolism,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Quorum sensing,GABAergic synapse,Type I diabetes mellitus 294.0 60.0 59.0 2.0 0.983606557377049 E 17.0 44.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 61.0 0.2786885245901639 0.7213114754098361 0.0776322182407575 0.177174448793989 0.1274033335173732 0.0995422305532315 0 0 0 0 K01581 0.2171428571428571 0.2108262108262108 E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17] path:map00330,path:map00480,path:map01100,path:map01110 Arginine and proline metabolism,Glutathione metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 172.0 168.0 166.0 2.0 0.988235294117647 E 79.0 91.0 4.0 0.864705882352941 COG0019 Diaminopimelate_decarboxylase LysA 170.0 0.4647058823529412 0.5352941176470588 0.264413021007014 0.451254520935574 0.357833770971294 0.1868414999285599 0 0 0 0 K01582 0.0028571428571428 0.1481481481481481 E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18] path:map00310,path:map00960,path:map01100,path:map01110,path:map01120 Lysine degradation,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 346.0 58.0 0.0 1.0 1.0 E 1.0 57.0 1.0 1.0 COG1982 Arginine/lysine/ornithine_decarboxylase LdcC 58.0 0.0172413793103448 0.9827586206896552 0.0551950005175092 0.093923965884337 0.0745594832009231 0.0387289653668278 0 0 0 0 K01583 0.0 0.0341880341880341 E4.1.1.19; arginine decarboxylase [EC:4.1.1.19] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 408.0 12.0 0.0 1.0 1.0 E 0.0 12.0 1.0 1.0 COG1982 Arginine/lysine/ornithine_decarboxylase LdcC 12.0 0.0 1.0 0.0319509296228084 0.0479492209212997 0.039950075272054 0.0159982912984913 0 0 0 0 K01584 0.02 0.094017094017094 adiA; arginine decarboxylase [EC:4.1.1.19] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 553.0 29.0 16.0 2.0 0.69047619047619 E 7.0 35.0 6.0 0.761904761904762 COG1982 Arginine/lysine/ornithine_decarboxylase LdcC 42.0 0.1666666666666666 0.8333333333333334 0.0245405907236382 0.0477293644030678 0.036134977563353 0.0231887736794296 0 0 0 0 K01585 0.0657142857142857 0.4216524216524216 speA; arginine decarboxylase [EC:4.1.1.19] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 125.0 129.0 63.0 3.0 0.614285714285714 E 27.0 183.0 5.0 0.423809523809524 COG1166 Arginine_decarboxylase_(spermidine_biosynthesis) SpeA 210.0 0.1285714285714285 0.8714285714285714 0.0032332195947751 0.142040354646823 0.072636787120799 0.1388071350520479 0 0 0 0 K01586 0.5028571428571429 0.7977207977207977 lysA; diaminopimelate decarboxylase [EC:4.1.1.20] path:map00300,path:map00470,path:map01100,path:map01110,path:map01120,path:map01230 Lysine biosynthesis,D-Amino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 159.0 567.0 564.0 3.0 0.992994746059545 E 203.0 368.0 3.0 0.996497373029772 COG0019 Diaminopimelate_decarboxylase LysA 571.0 0.3555166374781086 0.6444833625218914 0.0178663336005332 0.725718992684337 0.3717926631424351 0.7078526590838038 0 0 0 0 K01587 0.0 0.0113960113960113 PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 190.0 4.0 0.0 1.0 1.0 F 0.0 4.0 1.0 1.0 COG0152 Phosphoribosylaminoimidazole-succinocarboxamide_synthase PurC 4.0 0.0 1.0 0.13365411651717 0.323515053374128 0.2285845849456489 0.189860936856958 0 0 0 0 K01588 0.6142857142857143 0.8062678062678063 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 110.0 507.0 0.0 1.0 1.0 F 220.0 287.0 1.0 1.0 COG0041 Phosphoribosylcarboxyaminoimidazole_(NCAIR)_mutase PurE 507.0 0.4339250493096647 0.5660749506903353 0.455602437192561 0.470274965570799 0.46293870138168 0.014672528378238 0 0 0 0 K01589 0.2114285714285714 0.4786324786324786 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 194.0 251.0 0.0 1.0 1.0 F 75.0 176.0 1.0 1.0 COG0026 Phosphoribosylaminoimidazole_carboxylase_(NCAIR_synthetase) PurK 251.0 0.298804780876494 0.701195219123506 0.0013318704534754 0.009630545782302 0.0054812081178887 0.0082986753288266 0 0 0 0 K01590 0.0028571428571428 0.0284900284900284 hdc, HDC; histidine decarboxylase [EC:4.1.1.22] path:map00340,path:map01100,path:map01110 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 229.0 12.0 11.0 2.0 0.923076923076923 E 2.0 11.0 2.0 0.769230769230769 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 13.0 0.1538461538461538 0.8461538461538461 0.054600134051932 0.193370402040052 0.123985268045992 0.1387702679881199 0 0 0 0 K01591 0.7114285714285714 0.8888888888888888 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 59.0 601.0 0.0 1.0 1.0 F 263.0 338.0 3.0 0.941763727121464 COG0284 Orotidine-5'-phosphate_decarboxylase PyrF 601.0 0.4376039933444259 0.562396006655574 0.0213376762713274 0.520298388751005 0.2708180325111662 0.4989607124796776 0 0 0 0 K01593 0.0 0.1082621082621082 DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105] path:map00350,path:map00360,path:map00380,path:map00901,path:map00950,path:map00965,path:map01100,path:map01110,path:map04361,path:map04726,path:map04728,path:map05030,path:map05031,path:map05034 Tyrosine metabolism,Phenylalanine metabolism,Tryptophan metabolism,Indole alkaloid biosynthesis,Isoquinoline alkaloid biosynthesis,Betalain biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Axon regeneration,Serotonergic synapse,Dopaminergic synapse,Cocaine addiction,Amphetamine addiction,Alcoholism 386.0 42.0 0.0 1.0 1.0 E 0.0 42.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 42.0 0.0 1.0 0.0377569045437316 0.630716674784741 0.3342367896642363 0.5929597702410094 0 0 0 0 K01594 0.0142857142857142 0.0028490028490028 468.0 6.0 0.0 1.0 1.0 E 5.0 1.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 6.0 0.8333333333333334 0.1666666666666666 0.0051056166247891 0.0126986473249846 0.0089021319748868 0.0075930307001955 0 0 0 0 K01595 0.2942857142857142 0.4159544159544159 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] path:map00620,path:map00680,path:map00710,path:map00720,path:map01100,path:map01120,path:map01200 Pyruvate metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 258.0 137.0 73.0 3.0 0.520912547528517 C 108.0 155.0 2.0 0.692015209125475 COG2352 Phosphoenolpyruvate_carboxylase Ppc 263.0 0.4106463878326996 0.5893536121673004 0.605816097059377 0.692558783412436 0.6491874402359066 0.086742686353059 0 1 0 1 K01596 0.1771428571428571 0.2279202279202279 E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] path:map00010,path:map00020,path:map00620,path:map01100,path:map01110,path:map01120,path:map03320,path:map04068,path:map04151,path:map04152,path:map04910,path:map04920,path:map04922,path:map04931,path:map04964 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,PPAR signaling pathway,FoxO signaling pathway,PI3K-Akt signaling pathway,AMPK signaling pathway,Insulin signaling pathway,Adipocytokine signaling pathway,Glucagon signaling pathway,Insulin resistance,Proximal tubule bicarbonate reclamation 437.0 75.0 4.0 3.0 0.503355704697987 C 66.0 83.0 1.0 1.0 COG1274 Phosphoenolpyruvate_carboxykinase,_GTP-dependent PepCK 149.0 0.4429530201342282 0.5570469798657718 0.870259271303653 0.792831926635515 0.831545598969584 0.0774273446681379 1 1 1 1 K01597 0.1142857142857142 0.131054131054131 MVD, mvaD; diphosphomevalonate decarboxylase [EC:4.1.1.33] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 177.0 89.0 88.0 2.0 0.988888888888889 I 43.0 47.0 3.0 0.944444444444444 COG3407 Mevalonate_pyrophosphate_decarboxylase MVD1 90.0 0.4777777777777778 0.5222222222222223 0.398527341524468 0.494745117985893 0.4466362297551804 0.0962177764614249 0 0 0 0 K01598 0.0228571428571428 0.2592592592592592 PPCDC, coaC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 166.0 106.0 0.0 1.0 1.0 H 8.0 98.0 1.0 1.0 COG0452 Phosphopantothenoylcysteine_synthetase/decarboxylase_CoaBC CoaBC 106.0 0.0754716981132075 0.9245283018867924 0.0513403671490973 0.107096260698362 0.0792183139237296 0.0557558935492647 0 0 0 0 K01599 0.2685714285714285 0.6695156695156695 hemE, UROD; uroporphyrinogen decarboxylase [EC:4.1.1.37] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 36.0 551.0 0.0 1.0 1.0 H 222.0 329.0 1.0 1.0 COG0407 Uroporphyrinogen-III_decarboxylase_HemE HemE 551.0 0.4029038112522686 0.5970961887477314 0.465046093585905 0.752245333892496 0.6086457137392005 0.287199240306591 0 0 0 0 K01601 0.4342857142857143 0.1623931623931624 rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] path:map00630,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 297.0 231.0 216.0 2.0 0.939024390243902 G 173.0 73.0 2.0 0.995934959349594 COG1850 Ribulose_1,5-bisphosphate_carboxylase,_large_subunit,_or_a_RuBisCO-like_protein RbcL 246.0 0.7032520325203252 0.2967479674796748 0.800187192785424 0.908253307305806 0.8542202500456151 0.1080661145203819 1 1 1 1 K01602 0.0 0.0911680911680911 rbcS, cbbS; ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39] path:map00630,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 102.0 34.0 0.0 1.0 1.0 C 0.0 34.0 1.0 1.0 COG4451 Ribulose_bisphosphate_carboxylase_small_subunit RbcS 34.0 0.0 1.0 0.020375887636278 0.0170620110581773 0.0187189493472276 0.0033138765781006 0 0 0 0 K01607 0.1371428571428571 0.3076923076923077 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 29.0 224.0 210.0 6.0 0.888888888888889 S 65.0 184.0 3.0 0.896825396825397 COG0599 Uncharacterized_conserved_protein_YurZ,_alkylhydroperoxidase/carboxymuconolactone_decarboxylase_family YurZ 249.0 0.2610441767068273 0.7389558232931727 0.0055473876315231 0.509883263352076 0.2577153254917995 0.5043358757205529 0 0 0 0 K01608 0.0 0.0512820512820512 gcl; tartronate-semialdehyde synthase [EC:4.1.1.47] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 565.0 19.0 0.0 1.0 1.0 S 0.0 19.0 1.0 1.0 COG3960 Glyoxylate_carboligase Gcl 19.0 0.0 1.0 0.0110954141764865 0.0216185425528553 0.0163569783646709 0.0105231283763688 0 0 0 0 K01609 0.4657142857142857 0.7321937321937322 trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 120.0 431.0 427.0 2.0 0.990804597701149 E 165.0 269.0 2.0 0.993103448275862 COG0134 Indole-3-glycerol_phosphate_synthase TrpC 434.0 0.380184331797235 0.619815668202765 0.0183183627031162 0.258597932456174 0.1384581475796451 0.2402795697530578 0 0 0 0 K01610 0.2057142857142857 0.4245014245014245 E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] path:map00010,path:map00020,path:map00620,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 330.0 111.0 16.0 3.0 0.478448275862069 H 75.0 157.0 2.0 0.961206896551724 COG1866 Phosphoenolpyruvate_carboxykinase,_ATP-dependent PckA 232.0 0.3232758620689655 0.6767241379310345 0.0701568067980342 0.828952096143893 0.4495544514709635 0.7587952893458588 0 0 0 0 K01611 0.4085714285714286 0.3903133903133903 speD, AMD1; S-adenosylmethionine decarboxylase [EC:4.1.1.50] path:map00270,path:map00330,path:map01100 Cysteine and methionine metabolism,Arginine and proline metabolism,Metabolic pathways 45.0 235.0 174.0 3.0 0.681159420289855 E 201.0 155.0 5.0 0.957865168539326 COG1586 S-adenosylmethionine_decarboxylase SpeD 356.0 0.5646067415730337 0.4353932584269663 0.105986182834081 0.0181293790485903 0.0620577809413356 0.0878568037854907 0 0 0 0 K01612 0.0057142857142857 0.0142450142450142 bsdC; vanillate/4-hydroxybenzoate decarboxylase subunit C [EC:4.1.1.- 4.1.1.61] path:map00627,path:map01120,path:map01220 Aminobenzoate degradation,Microbial metabolism in diverse environments,Degradation of aromatic compounds 350.0 10.0 0.0 1.0 1.0 H 2.0 8.0 1.0 1.0 COG0043 3-polyprenyl-4-hydroxybenzoate_decarboxylase UbiD 10.0 0.2 0.8 0.0225029884271347 0.0876939878232616 0.0550984881251981 0.0651909993961269 0 0 0 0 K01613 0.2685714285714285 0.5470085470085471 psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] path:map00564,path:map01100,path:map01110 Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 71.0 312.0 309.0 3.0 0.987341772151899 I 99.0 217.0 3.0 0.987341772151899 COG0688 Phosphatidylserine_decarboxylase Psd 316.0 0.3132911392405063 0.6867088607594937 0.060823827577842 0.414399851813041 0.2376118396954415 0.353576024235199 0 0 0 0 K01615 0.0 0.037037037037037 gcdA; glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5] path:map00362,path:map00650,path:map01100,path:map01120 Benzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 122.0 13.0 9.0 3.0 0.722222222222222 I 0.0 18.0 4.0 0.555555555555556 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 18.0 0.0 1.0 0.0091047897279928 0.0116857118742979 0.0103952508011453 0.002580922146305 0 0 0 0 K01616 0.0 0.0769230769230769 kgd; multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61] path:map00020,path:map00630,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 1085.0 27.0 0.0 1.0 1.0 C 0.0 27.0 2.0 0.851851851851852 COG0508 Pyruvate/2-oxoglutarate_dehydrogenase_complex,_dihydrolipoamide_acyltransferase_(E2)_component AceF 27.0 0.0 1.0 0.0046510299281512 0.0097453515927618 0.0071981907604565 0.0050943216646106 0 0 0 0 K01617 0.0 0.0769230769230769 dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77] path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 223.0 33.0 0.0 1.0 1.0 Q 0.0 33.0 1.0 1.0 COG3971 2-keto-4-pentenoate_hydratase MhpD 33.0 0.0 1.0 0.003858278523169 0.009537003390485 0.006697640956827 0.005678724867316 0 0 0 0 K01619 0.3228571428571428 0.584045584045584 deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4] path:map00030,path:map01100 Pentose phosphate pathway,Metabolic pathways 141.0 289.0 243.0 3.0 0.811797752808989 F 122.0 234.0 1.0 1.0 COG0274 Deoxyribose-phosphate_aldolase DeoC 356.0 0.3426966292134831 0.6573033707865169 0.0343095012490087 0.213809445955679 0.1240594736023438 0.1794999447066703 0 0 0 0 K01620 0.2057142857142857 0.5242165242165242 ltaE; threonine aldolase [EC:4.1.2.48] path:map00260,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 187.0 265.0 242.0 2.0 0.920138888888889 E 82.0 206.0 7.0 0.833333333333333 COG2008 Threonine_aldolase GLY1 288.0 0.2847222222222222 0.7152777777777778 0.0517238335690732 0.443710507789616 0.2477171706793446 0.3919866742205428 0 0 0 0 K01621 0.0028571428571428 0.1823361823361823 xfp, xpk; xylulose-5-phosphate/fructose-6-phosphate phosphoketolase [EC:4.1.2.9 4.1.2.22] path:map00030,path:map00710,path:map01100,path:map01120 Pentose phosphate pathway,Carbon fixation in photosynthetic organisms,Metabolic pathways,Microbial metabolism in diverse environments 751.0 74.0 66.0 2.0 0.902439024390244 G 1.0 81.0 1.0 1.0 COG3957 Phosphoketolase XFP 82.0 0.0121951219512195 0.9878048780487804 0.0677792911052928 0.15624316272385 0.1120112269145714 0.0884638716185572 0 0 0 0 K01622 0.4485714285714285 0.0712250712250712 K01622; fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11] path:map00010,path:map00030,path:map00051,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 351.0 190.0 0.0 1.0 1.0 G 164.0 26.0 1.0 1.0 COG1980 Archaeal_fructose_1,6-bisphosphatase FbpA 190.0 0.8631578947368421 0.1368421052631579 0.404574247392922 0.0046959543549681 0.204635100873945 0.3998782930379539 0 0 0 0 K01623 0.0314285714285714 0.1623931623931624 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map04066 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,HIF-1 signaling pathway 248.0 70.0 69.0 3.0 0.972222222222222 G 12.0 60.0 1.0 1.0 COG3588 Fructose-bisphosphate_aldolase_class_1 Fba1 72.0 0.1666666666666666 0.8333333333333334 0.0180121840846862 0.561133295889739 0.2895727399872126 0.5431211118050528 0 0 0 0 K01624 0.1285714285714285 0.7150997150997151 FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 156.0 361.0 354.0 5.0 0.960106382978723 G 47.0 329.0 2.0 0.981382978723404 COG0191 Fructose/tagatose_bisphosphate_aldolase Fba 376.0 0.125 0.875 0.175001938268174 0.294470188944774 0.234736063606474 0.1194682506766 0 0 0 0 K01625 0.1 0.452991452991453 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] path:map00030,path:map00630,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 126.0 246.0 0.0 1.0 1.0 G 45.0 201.0 2.0 0.995934959349594 COG0800 2-keto-3-deoxy-6-phosphogluconate_aldolase Eda 246.0 0.1829268292682926 0.8170731707317073 0.729868335864215 0.346388794479688 0.5381285651719515 0.3834795413845269 0 1 0 1 K01626 0.0057142857142857 0.452991452991453 E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] path:map00400,path:map01100,path:map01110,path:map01230,path:map02024 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Quorum sensing 216.0 211.0 207.0 2.0 0.981395348837209 E 2.0 213.0 4.0 0.548837209302326 COG0722 3-deoxy-D-arabino-heptulosonate_7-phosphate_(DAHP)_synthase AroG1 215.0 0.0093023255813953 0.9906976744186048 0.0036535486895759 0.155595996715414 0.0796247727024949 0.1519424480258381 0 0 0 0 K01627 0.0085714285714285 0.5270655270655271 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 206.0 182.0 164.0 4.0 0.883495145631068 M 3.0 203.0 4.0 0.936893203883495 COG2877 3-deoxy-D-manno-octulosonic_acid_(KDO)_8-phosphate_synthase KdsA 206.0 0.0145631067961165 0.9854368932038836 0.067154279482952 0.315183280862972 0.191168780172962 0.24802900138002 0 0 0 0 K01628 0.4457142857142857 0.4273504273504273 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 18.0 339.0 334.0 6.0 0.957627118644068 G 165.0 188.0 8.0 0.951977401129944 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 353.0 0.4674220963172804 0.5325779036827195 0.76429001252343 0.791276737133012 0.777783374828221 0.026986724609582 1 1 1 1 K01629 0.0057142857142857 0.0797720797720797 rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 198.0 15.0 3.0 3.0 0.5 G 2.0 28.0 2.0 0.6 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 30.0 0.0666666666666666 0.9333333333333332 0.0429249818665272 0.21253790046995 0.1277314411682386 0.1696129186034228 0 0 0 0 K01630 0.0942857142857142 0.0797720797720797 garL; 2-dehydro-3-deoxyglucarate aldolase [EC:4.1.2.20] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 188.0 68.0 65.0 3.0 0.944444444444444 G 35.0 37.0 1.0 1.0 COG3836 2-keto-3-deoxy-L-rhamnonate_aldolase_RhmA HpcH 72.0 0.4861111111111111 0.5138888888888888 0.0180185754257633 0.0392280581512597 0.0286233167885115 0.0212094827254964 0 0 0 0 K01631 0.0 0.0427350427350427 dgoA; 2-dehydro-3-deoxyphosphogalactonate aldolase [EC:4.1.2.21] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 198.0 14.0 13.0 2.0 0.933333333333333 G 0.0 15.0 2.0 0.933333333333333 COG0800 2-keto-3-deoxy-6-phosphogluconate_aldolase Eda 15.0 0.0 1.0 0.0359689727987997 0.0730133772481579 0.0544911750234788 0.0370444044493582 0 0 0 0 K01633 0.0428571428571428 0.5754985754985755 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 31.0 218.0 216.0 3.0 0.986425339366516 H 15.0 211.0 7.0 0.938053097345133 COG1539 Dihydroneopterin_aldolase FolB 226.0 0.0663716814159292 0.9336283185840708 0.0012799925397713 0.16807328673514 0.0846766396374556 0.1667932941953687 0 0 0 0 K01634 0.0485714285714285 0.0626780626780626 SGPL1, DPL1; sphinganine-1-phosphate aldolase [EC:4.1.2.27] path:map00600,path:map01100,path:map04071 Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway 310.0 43.0 39.0 2.0 0.914893617021277 E 20.0 27.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 47.0 0.425531914893617 0.574468085106383 0.207879939792848 0.956557386908616 0.582218663350732 0.748677447115768 0 0 0 0 K01635 0.0057142857142857 0.0712250712250712 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] path:map00052,path:map01100,path:map02024 Galactose metabolism,Metabolic pathways,Quorum sensing 249.0 27.0 25.0 2.0 0.931034482758621 G 2.0 27.0 2.0 0.931034482758621 COG3684 Tagatose-1,6-bisphosphate/sulfofructosephosphate_aldolase LacD 29.0 0.0689655172413793 0.9310344827586208 0.0402496620772748 0.502323267741238 0.2712864649092564 0.4620736056639632 0 0 0 0 K01637 0.08 0.2535612535612536 E4.1.3.1, aceA; isocitrate lyase [EC:4.1.3.1] path:map00630,path:map01100,path:map01110,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 273.0 95.0 75.0 5.0 0.7421875 C 28.0 100.0 3.0 0.7421875 COG2224 Isocitrate_lyase AceA 128.0 0.21875 0.78125 0.0212992725175044 0.0795737245014828 0.0504364985094935 0.0582744519839784 0 0 0 0 K01638 0.0342857142857142 0.2991452991452991 aceB, glcB; malate synthase [EC:2.3.3.9] path:map00620,path:map00630,path:map01100,path:map01110,path:map01120,path:map01200 Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 360.0 105.0 80.0 2.0 0.807692307692308 C 12.0 118.0 2.0 0.992307692307692 COG2225 Malate_synthase AceB 130.0 0.0923076923076923 0.9076923076923076 0.0203028556954723 0.424794240755412 0.2225485482254421 0.4044913850599397 0 0 0 0 K01639 0.0571428571428571 0.0997150997150997 E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 190.0 39.0 16.0 3.0 0.609375 EM 21.0 43.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 64.0 0.328125 0.671875 0.045655781086974 0.195029194266954 0.120342487676964 0.14937341317998 0 0 0 0 K01640 0.0171428571428571 0.3447293447293447 HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] path:map00280,path:map00281,path:map00650,path:map01100,path:map01110,path:map04146 Valine, leucine and isoleucine degradation,Geraniol degradation,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Peroxisome 228.0 142.0 139.0 2.0 0.979310344827586 E 6.0 139.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 145.0 0.0413793103448275 0.9586206896551724 0.0701033673544926 0.933649394353154 0.5018763808538232 0.8635460269986613 0 0 0 0 K01641 0.7428571428571429 0.094017094017094 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] path:map00280,path:map00650,path:map00900,path:map01100,path:map01110,path:map03320 Valine, leucine and isoleucine degradation,Butanoate metabolism,Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,PPAR signaling pathway 232.0 351.0 0.0 1.0 1.0 I 314.0 37.0 4.0 0.917378917378917 COG3425 3-hydroxy-3-methylglutaryl_CoA_synthase PksG 351.0 0.8945868945868946 0.1054131054131054 0.509241533412206 0.16291148198944 0.336076507700823 0.346330051422766 0 1 0 1 K01643 0.0314285714285714 0.0626780626780626 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] path:map02020 Two-component system 377.0 43.0 37.0 2.0 0.877551020408163 C 16.0 33.0 3.0 0.693877551020408 COG3051 Citrate_lyase,_alpha_subunit CitF 49.0 0.3265306122448979 0.673469387755102 0.117470702330656 0.202194305229977 0.1598325037803165 0.084723602899321 0 0 0 0 K01644 0.1942857142857142 0.2962962962962963 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] path:map02020 Two-component system 160.0 236.0 225.0 3.0 0.918287937743191 G 77.0 180.0 2.0 0.992217898832685 COG2301 Citrate_lyase_beta_subunit CitE 257.0 0.2996108949416342 0.7003891050583657 0.0658744886924312 0.489138233536641 0.2775063611145361 0.4232637448442098 0 0 0 0 K01646 0.0085714285714285 0.0512820512820512 citD; citrate lyase subunit gamma (acyl carrier protein) path:map02020 Two-component system 81.0 27.0 24.0 3.0 0.870967741935484 C 3.0 28.0 2.0 0.838709677419355 COG3052 Acyl-carrier_protein_(citrate_lyase_gamma_subunit) CitD 31.0 0.0967741935483871 0.9032258064516128 0.115619602758318 0.778590556307552 0.447105079532935 0.6629709535492341 0 0 0 0 K01647 0.44 0.6866096866096866 CS, gltA; citrate synthase [EC:2.3.3.1] path:map00020,path:map00630,path:map01100,path:map01110,path:map01120,path:map01200,path:map01210,path:map01230 Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 181.0 479.0 427.0 6.0 0.88539741219963 C 203.0 341.0 5.0 0.979779411764706 COG0372 Citrate_synthase GltA 544.0 0.3731617647058823 0.6268382352941176 0.0239294020700395 0.307949990143425 0.1659396961067322 0.2840205880733855 0 0 0 0 K01648 0.0142857142857142 0.0056980056980056 ACLY; ATP citrate (pro-S)-lyase [EC:2.3.3.8] path:map00020,path:map00720,path:map01100,path:map01110,path:map01120 Citrate cycle (TCA cycle),Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 374.0 9.0 0.0 1.0 1.0 C 6.0 3.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 9.0 0.6666666666666666 0.3333333333333333 1.02282168285672e-11 0.0538591801100067 0.0269295900601174 0.0538591800997784 0 0 0 0 K01649 0.6228571428571429 0.7464387464387464 leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] path:map00290,path:map00620,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 199.0 770.0 694.0 4.0 0.885057471264368 E 372.0 498.0 4.0 0.972413793103448 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 870.0 0.4275862068965517 0.5724137931034483 0.187821108179 0.62738378572153 0.407602446950265 0.43956267754253 0 0 0 0 K01652 0.5485714285714286 0.7834757834757835 E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] path:map00290,path:map00650,path:map00660,path:map00770,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Butanoate metabolism,C5-Branched dibasic acid metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 184.0 395.0 31.0 4.0 0.407636738906089 EH 351.0 618.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 969.0 0.3622291021671827 0.6377708978328174 0.147309482339873 0.794329113346413 0.470819297843143 0.6470196310065399 0 0 0 0 K01653 0.3942857142857143 0.7122507122507122 E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] path:map00290,path:map00650,path:map00660,path:map00770,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Butanoate metabolism,C5-Branched dibasic acid metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 117.0 405.0 402.0 4.0 0.98780487804878 E 140.0 270.0 2.0 0.997560975609756 COG0440 Acetolactate_synthase,_small_subunit IlvH 410.0 0.3414634146341463 0.6585365853658537 0.011694863220267 0.716356794874861 0.364025829047564 0.704661931654594 0 0 0 0 K01654 0.1428571428571428 0.3532763532763532 neuB, nnaB; N-acetylneuraminate synthase [EC:2.5.1.56] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 196.0 210.0 198.0 5.0 0.91703056768559 M 61.0 168.0 7.0 0.903930131004367 COG2089 Sialic_acid_synthase_SpsE,_contains_C-terminal_SAF_domain SpsE 229.0 0.2663755458515284 0.7336244541484717 0.332037192454803 0.896878035199867 0.614457613827335 0.564840842745064 0 0 0 0 K01655 0.0 0.0398860398860398 LYS21, LYS20; homocitrate synthase [EC:2.3.3.14] path:map00300,path:map00620,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Lysine biosynthesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 355.0 13.0 12.0 2.0 0.928571428571429 E 0.0 14.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 14.0 0.0 1.0 0.0137904416027869 0.763847743819044 0.3888190927109154 0.7500573022162571 0 0 0 0 K01657 0.4485714285714285 0.7521367521367521 trpE; anthranilate synthase component I [EC:4.1.3.27] path:map00400,path:map00405,path:map01100,path:map01110,path:map01230,path:map02024,path:map02025 Phenylalanine, tyrosine and tryptophan biosynthesis,Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 222.0 290.0 89.0 5.0 0.540037243947858 E 204.0 333.0 5.0 0.945996275605214 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 537.0 0.3798882681564245 0.6201117318435754 0.518980868048298 0.762699294756944 0.6408400814026209 0.2437184267086459 0 1 0 1 K01658 0.4628571428571428 0.7094017094017094 trpG; anthranilate synthase component II [EC:4.1.3.27] path:map00400,path:map00405,path:map01100,path:map01110,path:map01230,path:map02024,path:map02025 Phenylalanine, tyrosine and tryptophan biosynthesis,Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 110.0 311.0 134.0 3.0 0.613412228796844 EH 209.0 298.0 2.0 0.962524654832347 COG0512 Anthranilate/para-aminobenzoate_synthase_component_II_(glutamine_amidotransferase) PabA 507.0 0.4122287968441814 0.5877712031558185 0.0073851097803963 0.0079558128320149 0.0076704613062055 0.0005707030516185 0 0 0 0 K01659 0.0285714285714285 0.1367521367521367 prpC; 2-methylcitrate synthase [EC:2.3.3.5] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 296.0 54.0 48.0 2.0 0.9 C 11.0 49.0 2.0 0.983333333333333 COG0372 Citrate_synthase GltA 60.0 0.1833333333333333 0.8166666666666667 0.0411294626519133 0.305548032227478 0.1733387474396956 0.2644185695755647 0 0 0 0 K01661 0.1542857142857142 0.301994301994302 menB; naphthoate synthase [EC:4.1.3.36] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 251.0 160.0 155.0 3.0 0.958083832335329 H 55.0 112.0 3.0 0.958083832335329 COG0447 1,4-Dihydroxy-2-naphthoyl-CoA_synthase MenB 167.0 0.3293413173652694 0.6706586826347305 0.0165024624533653 0.0039554936556509 0.010228978054508 0.0125469687977144 0 0 0 0 K01662 0.0028571428571428 0.7749287749287749 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] path:map00730,path:map00900,path:map01100,path:map01110 Thiamine metabolism,Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 396.0 230.0 194.0 4.0 0.790378006872852 H 1.0 290.0 1.0 1.0 COG1154 Deoxyxylulose-5-phosphate_synthase Dxs 291.0 0.0034364261168384 0.9965635738831616 0.735093364610999 0.691139318101609 0.713116341356304 0.0439540465093899 0 0 0 1 K01663 0.0 0.0541310541310541 HIS7; imidazole glycerol-phosphate synthase [EC:4.3.2.10] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 248.0 21.0 0.0 1.0 1.0 E 0.0 19.0 2.0 0.904761904761905 COG0107 Imidazole_glycerol_phosphate_synthase_subunit_HisF HisF 19.0 0.0 1.0 0.0163375545403027 0.0738078240792414 0.045072689309772 0.0574702695389387 0 0 0 0 K01664 0.04 0.4131054131054131 pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 160.0 171.0 170.0 2.0 0.994186046511628 EH 15.0 157.0 1.0 1.0 COG0512 Anthranilate/para-aminobenzoate_synthase_component_II_(glutamine_amidotransferase) PabA 172.0 0.0872093023255814 0.9127906976744186 0.207790047730089 0.561803845553777 0.384796946641933 0.354013797823688 0 0 0 0 K01665 0.02 0.5299145299145299 pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 172.0 195.0 184.0 4.0 0.906976744186046 EH 7.0 208.0 4.0 0.837209302325581 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 215.0 0.0325581395348837 0.9674418604651164 0.0510634026399785 0.359981207276462 0.2055223049582202 0.3089178046364835 0 0 0 0 K01666 0.0142857142857142 0.1623931623931624 mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] path:map00360,path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 253.0 61.0 45.0 3.0 0.782051282051282 E 5.0 73.0 2.0 0.987179487179487 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 78.0 0.0641025641025641 0.935897435897436 0.0437323860111373 0.290776276872278 0.1672543314417076 0.2470438908611406 0 0 0 0 K01667 0.1 0.1424501424501424 tnaA; tryptophanase [EC:4.1.99.1] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 423.0 85.0 83.0 2.0 0.977011494252874 E 35.0 52.0 1.0 1.0 COG3033 Tryptophanase TnaA 87.0 0.4022988505747126 0.5977011494252874 0.398892614195333 0.598555139299455 0.498723876747394 0.199662525104122 0 0 0 0 K01668 0.0085714285714285 0.0199430199430199 E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2] path:map00350 Tyrosine metabolism 448.0 12.0 0.0 1.0 1.0 E 3.0 9.0 1.0 1.0 COG3033 Tryptophanase TnaA 12.0 0.25 0.75 0.285804957317371 0.305711319047461 0.295758138182416 0.01990636173009 0 0 0 0 K01669 0.2657142857142857 0.4843304843304843 phr, PHR1; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 140.0 364.0 338.0 3.0 0.921518987341772 L 139.0 256.0 1.0 1.0 COG0415 Deoxyribodipyrimidine_photolyase PhrB 395.0 0.3518987341772152 0.6481012658227848 0.0159492430996197 0.131459297851002 0.0737042704753108 0.1155100547513822 0 0 0 0 K01671 0.0 0.0142450142450142 yihT; sulfofructosephosphate aldolase [EC:4.1.2.57] 276.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG3684 Tagatose-1,6-bisphosphate/sulfofructosephosphate_aldolase LacD 6.0 0.0 1.0 8.648699620735949e-12 0.107304932495522 0.0536524662520853 0.1073049324868733 0 0 0 0 K01673 0.2342857142857143 0.5612535612535613 cynT, can; carbonic anhydrase [EC:4.2.1.1] path:map00910,path:map01100 Nitrogen metabolism,Metabolic pathways 31.0 367.0 346.0 2.0 0.945876288659794 P 95.0 292.0 3.0 0.974226804123711 COG0288 Carbonic_anhydrase CynT 387.0 0.2454780361757106 0.7545219638242894 0.0138399709237144 0.125097535498107 0.0694687532109107 0.1112575645743926 0 0 0 0 K01674 0.0 0.094017094017094 cah; carbonic anhydrase [EC:4.2.1.1] path:map00910,path:map01100 Nitrogen metabolism,Metabolic pathways 149.0 34.0 32.0 2.0 0.944444444444444 P 0.0 36.0 3.0 0.944444444444444 COG3338 Carbonic_anhydrase Cah 36.0 0.0 1.0 0.0398468469323896 0.0929093618516282 0.0663781043920088 0.0530625149192385 0 0 0 0 K01676 0.0885714285714285 0.301994301994302 E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2] path:map00020,path:map00620,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 239.0 154.0 0.0 1.0 1.0 C 37.0 117.0 2.0 0.785714285714286 COG1838 Tartrate_dehydratase_beta_subunit/Fumarate_hydratase_class_I,_C-terminal_domain FumA 154.0 0.2402597402597402 0.7597402597402597 0.0636618091596894 0.605522672094102 0.3345922406268957 0.5418608629344126 0 0 0 0 K01677 0.3542857142857142 0.2222222222222222 E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2] path:map00020,path:map00620,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 206.0 217.0 0.0 1.0 1.0 C 136.0 80.0 2.0 0.981566820276498 COG1951 Tartrate_dehydratase_alpha_subunit/Fumarate_hydratase_class_I,_N-terminal_domain TtdA 216.0 0.6296296296296297 0.3703703703703703 0.94593492064146 0.943513888480641 0.9447244045610506 0.002421032160819 1 1 1 1 K01678 0.3457142857142857 0.2649572649572649 E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2] path:map00020,path:map00620,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 128.0 231.0 0.0 1.0 1.0 C 133.0 98.0 1.0 1.0 COG1838 Tartrate_dehydratase_beta_subunit/Fumarate_hydratase_class_I,_C-terminal_domain FumA 231.0 0.5757575757575758 0.4242424242424242 0.371124472553998 0.899678213787529 0.6354013431707635 0.528553741233531 0 0 0 0 K01679 0.3228571428571428 0.5698005698005698 E4.2.1.2B, fumC, FH; fumarate hydratase, class II [EC:4.2.1.2] path:map00020,path:map00620,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map04934,path:map05200,path:map05211 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Cushing syndrome,Pathways in cancer,Renal cell carcinoma 395.0 296.0 274.0 4.0 0.925 C 116.0 204.0 3.0 0.915625 COG0114 Fumarate_hydratase_class_II FumC 320.0 0.3625 0.6375 0.641849218580013 0.590191119200144 0.6160201688900785 0.0516580993798689 0 1 0 1 K01681 0.4257142857142857 0.6752136752136753 ACO, acnA; aconitate hydratase [EC:4.2.1.3] path:map00020,path:map00630,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01210,path:map01230 Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 465.0 458.0 456.0 2.0 0.995652173913044 C 185.0 275.0 2.0 0.993478260869565 COG1048 Aconitase_A AcnA 460.0 0.4021739130434782 0.5978260869565217 0.535832393799898 0.0478532367731372 0.2918428152865176 0.4879791570267608 0 1 0 1 K01682 0.0085714285714285 0.1794871794871795 acnB; aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99] path:map00020,path:map00630,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01210,path:map01230 Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 806.0 71.0 0.0 1.0 1.0 C 3.0 68.0 1.0 1.0 COG1049 Aconitase_B AcnB 71.0 0.0422535211267605 0.9577464788732394 0.0047511955898843 0.0091122381755952 0.0069317168827397 0.0043610425857109 0 0 0 0 K01683 0.0628571428571428 0.0113960113960113 araD; D-arabinonate dehydratase [EC:4.2.1.5] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 293.0 35.0 0.0 1.0 1.0 M 24.0 11.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 35.0 0.6857142857142857 0.3142857142857143 0.0307988509769307 0.0736890733782936 0.0522439621776121 0.0428902224013629 0 0 0 0 K01684 0.1142857142857142 0.1253561253561253 dgoD; galactonate dehydratase [EC:4.2.1.6] path:map00052,path:map01100,path:map01120 Galactose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 188.0 200.0 0.0 1.0 1.0 M 76.0 124.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 200.0 0.38 0.62 0.0058259032334024 0.0208516774890076 0.013338790361205 0.0150257742556052 0 0 0 0 K01685 0.0085714285714285 0.1851851851851851 uxaA; altronate hydrolase [EC:4.2.1.7] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 384.0 86.0 0.0 1.0 1.0 G 3.0 83.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 86.0 0.0348837209302325 0.9651162790697676 0.826191227801783 0.21201775205421 0.5191044899279965 0.614173475747573 0 0 1 1 K01686 0.0742857142857142 0.1766381766381766 uxuA; mannonate dehydratase [EC:4.2.1.8] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 202.0 142.0 132.0 4.0 0.916129032258064 G 42.0 113.0 3.0 0.980645161290322 COG1312 D-mannonate_dehydratase UxuA 155.0 0.2709677419354839 0.7290322580645161 0.0045292225423843 0.0118373215756124 0.0081832720589983 0.007308099033228 0 0 0 0 K01687 0.4857142857142857 0.7293447293447294 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] path:map00290,path:map00770,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 426.0 231.0 12.0 4.0 0.438330170777989 EG 184.0 343.0 2.0 0.996204933586338 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 527.0 0.349146110056926 0.650853889943074 0.660456622843774 0.805519145043613 0.7329878839436935 0.1450625221998389 0 1 0 1 K01689 0.8628571428571429 0.9544159544159544 ENO, eno; enolase [EC:4.2.1.11] path:map00010,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map03018,path:map04066 Glycolysis / Gluconeogenesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,RNA degradation,HIF-1 signaling pathway 311.0 570.0 483.0 3.0 0.829694323144105 G 319.0 368.0 1.0 1.0 COG0148 Enolase Eno 687.0 0.4643377001455604 0.5356622998544396 0.542672356389855 0.727050345925472 0.6348613511576635 0.184377989535617 0 1 0 1 K01690 0.0 0.1253561253561253 edd; phosphogluconate dehydratase [EC:4.2.1.12] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 567.0 48.0 47.0 2.0 0.979591836734694 EG 0.0 49.0 1.0 1.0 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 49.0 0.0 1.0 0.0070513287884643 0.0178101996788502 0.0124307642336572 0.0107588708903859 0 0 0 0 K01692 0.04 0.301994301994302 paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17] path:map00071,path:map00280,path:map00281,path:map00310,path:map00360,path:map00362,path:map00380,path:map00410,path:map00627,path:map00640,path:map00650,path:map00903,path:map00930,path:map01100,path:map01110,path:map01120,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,Geraniol degradation,Lysine degradation,Phenylalanine metabolism,Benzoate degradation,Tryptophan metabolism,beta-Alanine metabolism,Aminobenzoate degradation,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation,Caprolactam degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Fatty acid metabolism 102.0 355.0 0.0 1.0 1.0 I 25.0 329.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 354.0 0.0706214689265536 0.9293785310734464 0.0082344593795261 0.162311683726342 0.085273071552934 0.1540772243468159 0 0 0 0 K01693 0.4742857142857143 0.7293447293447294 hisB; imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 141.0 427.0 426.0 2.0 0.997663551401869 E 169.0 259.0 3.0 0.992990654205608 COG0131 Imidazoleglycerol_phosphate_dehydratase_HisB HisB2 428.0 0.3948598130841121 0.6051401869158879 0.0018358616585714 0.0443115882736055 0.0230737249660884 0.0424757266150341 0 0 0 0 K01695 0.4857142857142857 0.7521367521367521 trpA; tryptophan synthase alpha chain [EC:4.2.1.20] path:map00260,path:map00400,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 155.0 433.0 425.0 3.0 0.977426636568849 E 173.0 270.0 1.0 1.0 COG0159 Tryptophan_synthase_alpha_chain TrpA 443.0 0.3905191873589165 0.6094808126410836 0.541267095873789 0.269540189683924 0.4054036427788565 0.2717269061898649 0 1 0 1 K01696 0.4685714285714286 0.7749287749287749 trpB; tryptophan synthase beta chain [EC:4.2.1.20] path:map00260,path:map00400,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 281.0 516.0 0.0 1.0 1.0 E 204.0 312.0 4.0 0.895348837209302 COG0133 Tryptophan_synthase_beta_chain TrpB 516.0 0.3953488372093023 0.6046511627906976 0.643129956085299 0.414504621236089 0.528817288660694 0.22862533484921 0 1 0 1 K01697 0.1285714285714285 0.2279202279202279 CBS; cystathionine beta-synthase [EC:4.2.1.22] path:map00260,path:map00270,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 259.0 115.0 88.0 4.0 0.798611111111111 E 50.0 93.0 1.0 1.0 COG0031 Cysteine_synthase CysK 143.0 0.3496503496503496 0.6503496503496503 0.0158469373849063 0.218291940048846 0.1170694387168761 0.2024450026639397 0 0 0 0 K01698 0.4571428571428571 0.6894586894586895 hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 233.0 425.0 388.0 3.0 0.91792656587473 H 212.0 251.0 2.0 0.91792656587473 COG0113 Delta-aminolevulinic_acid_dehydratase,_porphobilinogen_synthase HemB 463.0 0.4578833693304535 0.5421166306695464 0.0088207281222657 0.536762693285701 0.2727917107039834 0.5279419651634353 0 0 0 0 K01699 0.0028571428571428 0.0227920227920227 pduC; propanediol dehydratase large subunit [EC:4.2.1.28] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 554.0 9.0 8.0 2.0 0.9 Q 1.0 9.0 2.0 0.9 COG4909 Propanediol_dehydratase,_large_subunit PduC 10.0 0.1 0.9 0.0065475870301717 0.0315873902992785 0.0190674886647251 0.0250398032691068 0 0 0 0 K01703 0.6 0.7635327635327636 leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] path:map00290,path:map00660,path:map00966,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,C5-Branched dibasic acid metabolism,Glucosinolate biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 321.0 480.0 342.0 3.0 0.770465489566613 E 296.0 327.0 1.0 1.0 COG0065 Homoaconitase/3-isopropylmalate_dehydratase_large_subunit LeuC 623.0 0.4751203852327448 0.5248796147672552 0.426381764152722 0.939331535030261 0.6828566495914915 0.512949770877539 0 0 0 0 K01704 0.5628571428571428 0.7578347578347578 leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] path:map00290,path:map00660,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,C5-Branched dibasic acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 73.0 576.0 564.0 2.0 0.979591836734694 E 278.0 310.0 2.0 0.991496598639456 COG0066 3-isopropylmalate_dehydratase_small_subunit LeuD 588.0 0.4727891156462585 0.5272108843537415 0.289395178769793 0.697179142761265 0.493287160765529 0.407783963991472 0 0 0 0 K01705 0.0114285714285714 0.0142450142450142 LYS4; homoaconitate hydratase [EC:4.2.1.36] path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 409.0 11.0 0.0 1.0 1.0 E 5.0 6.0 2.0 0.909090909090909 COG0065 Homoaconitase/3-isopropylmalate_dehydratase_large_subunit LeuC 11.0 0.4545454545454545 0.5454545454545454 0.793840364960964 0.940495294214188 0.867167829587576 0.146654929253224 1 1 1 1 K01706 0.0028571428571428 0.0683760683760683 gudD; glucarate dehydratase [EC:4.2.1.40] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 335.0 34.0 0.0 1.0 1.0 M 1.0 33.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 34.0 0.0294117647058823 0.9705882352941176 0.020979061816561 0.0393689870134548 0.0301740244150079 0.0183899251968938 0 0 0 0 K01707 0.0028571428571428 0.0797720797720797 kdgD; 5-dehydro-4-deoxyglucarate dehydratase [EC:4.2.1.41] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 259.0 34.0 31.0 2.0 0.918918918918919 EM 1.0 36.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 37.0 0.027027027027027 0.972972972972973 0.0175220353766513 0.0338365638795928 0.025679299628122 0.0163145285029415 0 0 0 0 K01708 0.0 0.0569800569800569 garD; galactarate dehydratase [EC:4.2.1.42] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 468.0 20.0 19.0 2.0 0.952380952380952 G 0.0 21.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 21.0 0.0 1.0 0.127590704730542 0.29817439258778 0.212882548659161 0.170583687857238 0 0 0 0 K01709 0.1142857142857142 0.2136752136752136 rfbG; CDP-glucose 4,6-dehydratase [EC:4.2.1.45] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 212.0 85.0 38.0 2.0 0.643939393939394 M 44.0 88.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 132.0 0.3333333333333333 0.6666666666666666 0.571239127298343 0.805798252249422 0.6885186897738825 0.234559124951079 0 1 0 1 K01710 0.4685714285714286 0.8034188034188035 rfbB, rmlB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] path:map00521,path:map00523,path:map00525,path:map00541,path:map01055,path:map01100,path:map01110,path:map01250 Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,Acarbose and validamycin biosynthesis,O-Antigen nucleotide sugar biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 112.0 592.0 444.0 5.0 0.788282290279627 M 236.0 515.0 6.0 0.541944074567244 COG1088 dTDP-D-glucose_4,6-dehydratase RfbB 751.0 0.3142476697736351 0.6857523302263648 0.653551258087222 0.655266593275976 0.654408925681599 0.0017153351887539 0 1 0 1 K01711 0.1685714285714285 0.4729344729344729 gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47] path:map00051,path:map00520,path:map00541,path:map01100,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 259.0 293.0 272.0 4.0 0.927215189873417 M 73.0 243.0 3.0 0.987341772151899 COG1089 GDP-D-mannose_dehydratase Gmd 316.0 0.2310126582278481 0.7689873417721519 0.0034123969111103 0.645876810682145 0.3246446037966276 0.6424644137710347 0 0 0 0 K01712 0.2171428571428571 0.4017094017094017 hutU, UROC1; urocanate hydratase [EC:4.2.1.49] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 483.0 208.0 171.0 2.0 0.848979591836735 E 88.0 156.0 1.0 1.0 COG2987 Urocanate_hydratase HutU 244.0 0.360655737704918 0.639344262295082 0.427153125520823 0.915020964378585 0.6710870449497041 0.487867838857762 0 0 0 0 K01713 0.0685714285714285 0.0626780626780626 pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 132.0 35.0 22.0 2.0 0.729166666666667 E 24.0 24.0 2.0 0.729166666666667 COG0077 Prephenate_dehydratase PheA2 48.0 0.5 0.5 0.864088474529833 0.705545187822805 0.784816831176319 0.158543286707028 1 1 1 1 K01714 0.5885714285714285 0.8319088319088319 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] path:map00261,path:map00300,path:map01100,path:map01110,path:map01120,path:map01230 Monobactam biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 32.0 593.0 364.0 7.0 0.676940639269406 E 321.0 551.0 5.0 0.988584474885845 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 872.0 0.3681192660550458 0.6318807339449541 0.0232578532466498 0.364435307695309 0.1938465804709794 0.3411774544486592 0 0 0 0 K01715 0.2257142857142857 0.3219373219373219 crt; enoyl-CoA hydratase [EC:4.2.1.17] path:map00650,path:map01120,path:map01200 Butanoate metabolism,Microbial metabolism in diverse environments,Carbon metabolism 126.0 315.0 0.0 1.0 1.0 I 125.0 190.0 2.0 0.942857142857143 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 315.0 0.3968253968253968 0.6031746031746031 0.0397109883352105 0.654519277467559 0.3471151329013847 0.6148082891323485 0 0 0 0 K01716 0.0 0.1282051282051282 fabA; 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 159.0 45.0 0.0 1.0 1.0 I 0.0 45.0 1.0 1.0 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl_carrier_protein)_dehydratase FabA 45.0 0.0 1.0 0.0008905443181317 0.003759251988728 0.0023248981534298 0.0028687076705963 0 0 0 0 K01719 0.3914285714285714 0.4757834757834758 hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 19.0 344.0 334.0 6.0 0.92972972972973 H 152.0 218.0 9.0 0.862162162162162 COG1587 Uroporphyrinogen-III_synthase HemD 370.0 0.4108108108108108 0.5891891891891892 0.001671770737498 0.0012500122087545 0.0014608914731262 0.0004217585287434 0 0 0 0 K01720 0.1285714285714285 0.131054131054131 prpD; 2-methylcitrate dehydratase [EC:4.2.1.79] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 315.0 103.0 0.0 1.0 1.0 S 54.0 49.0 1.0 1.0 COG2079 2-methylcitrate_dehydratase_PrpD PrpD 103.0 0.5242718446601942 0.4757281553398058 0.0076105931093729 0.0138896783013538 0.0107501357053633 0.0062790851919809 0 0 0 0 K01721 0.0 0.0512820512820512 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84] path:map00364,path:map00380,path:map00627,path:map00643,path:map01100,path:map01120 Fluorobenzoate degradation,Tryptophan metabolism,Aminobenzoate degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 178.0 21.0 20.0 3.0 0.91304347826087 S 0.0 23.0 1.0 1.0 2BZ0R 23.0 0.0 1.0 0.011383261705603 0.0264573132041225 0.0189202874548627 0.0150740514985195 0 0 0 0 K01724 0.3371428571428571 0.4871794871794871 PCBD, phhB; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 41.0 328.0 323.0 3.0 0.982035928143712 H 133.0 200.0 3.0 0.970059880239521 COG2154 Pterin-4a-carbinolamine_dehydratase PhhB 333.0 0.3993993993993994 0.6006006006006006 0.0988091808655339 0.743815055403018 0.4213121181342759 0.645005874537484 0 0 0 0 K01725 0.0085714285714285 0.0797720797720797 cynS; cyanate lyase [EC:4.2.1.104] path:map00910,path:map01100 Nitrogen metabolism,Metabolic pathways 136.0 29.0 26.0 3.0 0.878787878787879 P 3.0 30.0 1.0 1.0 COG1513 Cyanate_lyase CynS 33.0 0.0909090909090909 0.9090909090909092 0.052288337777797 0.0724803293882064 0.0623843335830016 0.0201919916104093 0 0 0 0 K01727 0.0 0.0398860398860398 hysA, hylA, hylB; hyaluronate lyase [EC:4.2.2.1] 26.0 11.0 7.0 3.0 0.6875 N 0.0 16.0 9.0 0.375 COG5492 Uncharacterized_conserved_protein_YjdB,_contains_Ig-like_domain YjdB 16.0 0.0 1.0 0.049686846723708 0.225508384449211 0.1375976155864595 0.175821537725503 0 0 0 0 K01728 0.0028571428571428 0.1082621082621082 pel; pectate lyase [EC:4.2.2.2] path:map00040,path:map01100,path:map02024 Pentose and glucuronate interconversions,Metabolic pathways,Quorum sensing 50.0 47.0 40.0 7.0 0.671428571428571 G 1.0 64.0 15.0 0.585714285714286 COG3866 Pectate_lyase PelB 65.0 0.0153846153846153 0.9846153846153848 0.621834102650238 0.031624562684649 0.3267293326674435 0.590209539965589 0 0 0 1 K01729 0.0057142857142857 0.0968660968660968 algL; poly(beta-D-mannuronate) lyase [EC:4.2.2.3] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 21.0 22.0 15.0 8.0 0.407407407407407 P 2.0 52.0 16.0 0.351851851851852 COG3420 Nitrous_oxide_reductase_accessory_protein_NosD,_contains_tandem_CASH_domains NosD 54.0 0.037037037037037 0.9629629629629628 0.009271898310695 0.0267389965426834 0.0180054474266892 0.0174670982319884 0 0 0 0 K01730 0.0085714285714285 0.0398860398860398 ogl; oligogalacturonide lyase [EC:4.2.2.6] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 153.0 15.0 12.0 3.0 0.714285714285714 U 3.0 18.0 4.0 0.761904761904762 COG0823 Periplasmic_component_TolB_of_the_Tol_biopolymer_transport_system TolB 21.0 0.1428571428571428 0.8571428571428571 0.114075207591016 0.372302319068434 0.243188763329725 0.2582271114774179 0 0 0 0 K01731 0.0 0.0028490028490028 pelW; pectate disaccharide-lyase [EC:4.2.2.9] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 1235.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG4677 Pectin_methylesterase_and_related_acyl-CoA_thioesterases PemB 1.0 0.0 1.0 0 0 0 0 K01732 0.0 0.0142450142450142 E4.2.2.10; pectin lyase [EC:4.2.2.10] 152.0 4.0 1.0 2.0 0.571428571428571 M 0.0 7.0 3.0 0.714285714285714 COG0810 Periplasmic_protein_TonB,_links_inner_and_outer_membranes TonB 7.0 0.0 1.0 6.6687094360913185e-12 0.0828414476180573 0.041420723812363 0.0828414476113885 0 0 0 0 K01733 0.7 0.811965811965812 thrC; threonine synthase [EC:4.2.3.1] path:map00260,path:map00750,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 128.0 909.0 888.0 6.0 0.952830188679245 E 535.0 419.0 6.0 0.964360587002096 COG0498 Threonine_synthase ThrC 954.0 0.560796645702306 0.4392033542976939 0.435664920639518 0.415696067298927 0.4256804939692225 0.019968853340591 0 0 0 0 K01734 0.1 0.2535612535612536 mgsA; methylglyoxal synthase [EC:4.2.3.3] path:map00640,path:map01100,path:map01120 Propanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 96.0 123.0 117.0 3.0 0.946153846153846 G 35.0 95.0 3.0 0.976923076923077 COG1803 Methylglyoxal_synthase MgsA 130.0 0.2692307692307692 0.7307692307692307 0.0248986369896522 0.649078567130169 0.3369886020599106 0.6241799301405168 0 0 0 0 K01735 0.1228571428571428 0.7863247863247863 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 142.0 350.0 340.0 3.0 0.953678474114441 E 45.0 323.0 2.0 0.997275204359673 COG0337 3-dehydroquinate_synthetase AroB 368.0 0.1222826086956521 0.8777173913043478 0.0264583365709389 0.42606129424532 0.2262598154081294 0.3996029576743811 0 0 0 0 K01736 0.5714285714285714 0.8233618233618234 aroC; chorismate synthase [EC:4.2.3.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 234.0 499.0 486.0 3.0 0.968932038834952 E 215.0 300.0 2.0 0.974757281553398 COG0082 Chorismate_synthase AroC 515.0 0.4174757281553398 0.5825242718446602 6.97768401016635e-05 0.279135194542676 0.1396024856913888 0.2790654177025743 0 0 0 0 K01737 0.5457142857142857 0.6353276353276354 queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 25.0 530.0 528.0 3.0 0.99437148217636 H 231.0 302.0 3.0 0.99624765478424 COG0720 6-pyruvoyl-tetrahydropterin_synthase QueD 533.0 0.4333958724202627 0.5666041275797373 0.0833965917367427 0.347301988207193 0.2153492899719678 0.2639053964704503 0 0 0 0 K01738 0.4657142857142857 0.8034188034188035 cysK; cysteine synthase [EC:2.5.1.47] path:map00270,path:map00920,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 179.0 687.0 670.0 6.0 0.939808481532148 E 239.0 493.0 2.0 0.967168262653899 COG0031 Cysteine_synthase CysK 732.0 0.3265027322404371 0.6734972677595629 0.0079811974601796 0.314415099806636 0.1611981486334078 0.3064339023464564 0 0 0 0 K01739 0.3342857142857143 0.4928774928774929 metB; cystathionine gamma-synthase [EC:2.5.1.48] path:map00270,path:map00450,path:map00920,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 228.0 406.0 399.0 2.0 0.983050847457627 E 148.0 265.0 3.0 0.987893462469734 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 413.0 0.3583535108958838 0.6416464891041163 0.0267637932352751 0.576187748241402 0.3014757707383385 0.5494239550061268 0 0 0 0 K01740 0.2171428571428571 0.5470085470085471 metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 373.0 373.0 362.0 4.0 0.961340206185567 E 117.0 271.0 5.0 0.966494845360825 COG2873 O-acetylhomoserine/O-acetylserine_sulfhydrylase,_pyridoxal_phosphate-dependent MET17 388.0 0.3015463917525773 0.6984536082474226 0.022666330121505 0.607142280055364 0.3149043050884345 0.584475949933859 0 0 0 0 K01741 0.1485714285714285 0.0056980056980056 E4.2.99.18; DNA-(apurinic or apyrimidinic site) lyase [EC:4.2.99.18] 116.0 44.0 33.0 2.0 0.8 L 53.0 2.0 2.0 0.8 COG4047 N-glycosylase/DNA_lyase_(8-oxoguanine_DNA_glycosylase) 55.0 0.9636363636363636 0.0363636363636363 0.0101594466852014 0.130570923296164 0.0703651849906827 0.1204114766109625 0 0 0 0 K01744 0.12 0.2421652421652421 aspA; aspartate ammonia-lyase [EC:4.3.1.1] path:map00250,path:map01100 Alanine, aspartate and glutamate metabolism,Metabolic pathways 393.0 132.0 120.0 3.0 0.910344827586207 E 46.0 99.0 3.0 0.910344827586207 COG1027 Aspartate_ammonia-lyase AspA 145.0 0.3172413793103448 0.6827586206896552 0.0878126313583713 0.521211374299219 0.3045120028287951 0.4333987429408477 0 0 0 0 K01745 0.2257142857142857 0.4358974358974359 hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 350.0 284.0 281.0 2.0 0.989547038327526 E 90.0 197.0 1.0 1.0 COG2986 Histidine_ammonia-lyase HutH 287.0 0.313588850174216 0.686411149825784 0.890764347643256 0.981240987348677 0.9360026674959664 0.090476639705421 1 1 1 1 K01746 0.0 0.0 E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4] path:map00670,path:map01100 One carbon pool by folate,Metabolic pathways 51.0 0.0 1.0 1.0 E 0.0 0.0 2.0 0.784313725490196 COG3404 Formiminotetrahydrofolate_cyclodeaminase FtcD 0.0 0 0 0 0 K01749 0.4514285714285714 0.6894586894586895 hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 128.0 423.0 418.0 2.0 0.988317757009346 H 165.0 263.0 3.0 0.962616822429906 COG0181 Porphobilinogen_deaminase HemC 428.0 0.3855140186915888 0.6144859813084113 0.0365072385846722 0.309731790012876 0.1731195142987741 0.2732245514282038 0 0 0 0 K01750 0.04 0.2564102564102564 E4.3.1.12, ocd; ornithine cyclodeaminase [EC:4.3.1.12] path:map00330,path:map01100,path:map01110,path:map01230 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 162.0 153.0 152.0 2.0 0.993506493506493 E 18.0 136.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 154.0 0.1168831168831168 0.8831168831168831 0.12482388748264 0.913984808460605 0.5194043479716225 0.7891609209779651 0 0 0 0 K01751 0.0057142857142857 0.0997150997150997 E4.3.1.15; diaminopropionate ammonia-lyase [EC:4.3.1.15] 306.0 40.0 0.0 1.0 1.0 E 2.0 38.0 1.0 1.0 COG1171 Threonine_deaminase IlvA 40.0 0.05 0.95 0.0618282695690245 0.21657062096501 0.1391994452670172 0.1547423513959855 0 0 0 0 K01752 0.0314285714285714 0.4358974358974359 E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17] path:map00260,path:map00270,path:map01100,path:map01110,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism,Biosynthesis of amino acids 32.0 242.0 239.0 3.0 0.983739837398374 E 18.0 225.0 4.0 0.979674796747967 COG1760 L-serine_deaminase SdaA 243.0 0.074074074074074 0.925925925925926 0.22870321772766 0.593078276252023 0.4108907469898415 0.364375058524363 0 0 0 0 K01753 0.0 0.0826210826210826 dsdA; D-serine dehydratase [EC:4.3.1.18] path:map00260,path:map00470,path:map01100 Glycine, serine and threonine metabolism,D-Amino acid metabolism,Metabolic pathways 296.0 31.0 0.0 1.0 1.0 E 0.0 31.0 2.0 0.709677419354839 COG3048 D-serine_dehydratase DsdA 31.0 0.0 1.0 0.229726711215063 0.142665337479227 0.186196024347145 0.087061373735836 0 0 0 0 K01754 0.3742857142857143 0.6239316239316239 E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19] path:map00260,path:map00290,path:map01100,path:map01110,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Valine, leucine and isoleucine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism,Biosynthesis of amino acids 155.0 584.0 578.0 6.0 0.979865771812081 E 217.0 385.0 6.0 0.966832504145937 COG1171 Threonine_deaminase IlvA 602.0 0.3604651162790697 0.6395348837209303 0.006292383749644 0.0045427565765849 0.0054175701631144 0.0017496271730591 0 0 0 0 K01755 0.5542857142857143 0.7720797720797721 argH, ASL; argininosuccinate lyase [EC:4.3.2.1] path:map00220,path:map00250,path:map01100,path:map01110,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 253.0 492.0 488.0 7.0 0.976190476190476 E 201.0 303.0 4.0 0.984126984126984 COG0165 Argininosuccinate_lyase ArgH 504.0 0.3988095238095238 0.6011904761904762 0.227838343033789 0.680664229842069 0.454251286437929 0.4528258868082799 0 0 0 0 K01756 0.6971428571428572 0.886039886039886 purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2] path:map00230,path:map00250,path:map01100,path:map01110,path:map01232,path:map01240 Purine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism,Biosynthesis of cofactors 231.0 614.0 0.0 1.0 1.0 F 252.0 362.0 2.0 0.956026058631922 COG0015 Adenylosuccinate_lyase PurB 614.0 0.4104234527687296 0.5895765472312704 0.932807110946204 0.814109447817128 0.8734582793816661 0.118697663129076 1 1 1 1 K01757 0.0 0.0227920227920227 STR1; strictosidine synthase [EC:4.3.3.2] path:map00901,path:map01100,path:map01110 Indole alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 60.0 8.0 0.0 1.0 1.0 G 0.0 8.0 2.0 0.625 COG3386 Sugar_lactone_lactonase_YvrE YvrE 8.0 0.0 1.0 0.0213166333514593 0.0638070766228309 0.0425618549871451 0.0424904432713716 0 0 0 0 K01758 0.2228571428571428 0.245014245014245 CTH; cystathionine gamma-lyase [EC:4.4.1.1] path:map00260,path:map00270,path:map00450,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Selenocompound metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 298.0 187.0 169.0 3.0 0.907766990291262 E 95.0 111.0 2.0 0.912621359223301 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 206.0 0.4611650485436893 0.5388349514563107 0.0103417813440721 0.833587462088596 0.4219646217163341 0.8232456807445239 0 0 0 0 K01759 0.2485714285714285 0.5213675213675214 GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 11.0 473.0 467.0 3.0 0.979296066252588 E 178.0 305.0 3.0 0.962732919254658 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 483.0 0.3685300207039337 0.6314699792960663 0.0198559819955737 0.133662226476655 0.0767591042361143 0.1138062444810812 0 0 0 0 K01760 0.0571428571428571 0.3646723646723647 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] path:map00270,path:map00450,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Selenocompound metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 245.0 192.0 188.0 3.0 0.974619289340101 E 20.0 177.0 3.0 0.974619289340102 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 197.0 0.1015228426395939 0.8984771573604061 0.0048656801380462 0.0281621870061508 0.0165139335720985 0.0232965068681046 0 0 0 0 K01761 0.14 0.3133903133903133 E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11] path:map00270,path:map00450,path:map01100 Cysteine and methionine metabolism,Selenocompound metabolism,Metabolic pathways 259.0 204.0 0.0 1.0 1.0 E 54.0 150.0 3.0 0.96078431372549 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 204.0 0.2647058823529412 0.7352941176470589 0.170227003998592 0.954342741983874 0.562284872991233 0.784115737985282 0 0 0 0 K01766 0.0 0.0256410256410256 csdA; cysteine sulfinate desulfinase [EC:4.4.1.-] 398.0 10.0 8.0 2.0 0.833333333333333 E 0.0 12.0 1.0 1.0 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 12.0 0.0 1.0 0.0035369410403925 0.0081923325827633 0.0058646368115779 0.0046553915423707 0 0 0 0 K01768 0.0 0.0 E4.6.1.1; adenylate cyclase [EC:4.6.1.1] path:map00230,path:map01100,path:map02025,path:map04113,path:map04213 Purine metabolism,Metabolic pathways,Biofilm formation - Pseudomonas aeruginosa,Meiosis - yeast,Longevity regulating pathway - multiple species 623.0 555.0 13.0 0.843031123139378 T 0.0 0.0 52.0 0.529093369418133 COG2114 Adenylate_cyclase,_class_3 AcyC 0.0 0 0 0 0 K01769 0.0028571428571428 0.0313390313390313 E4.6.1.2; guanylate cyclase, other [EC:4.6.1.2] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 279.0 12.0 0.0 1.0 1.0 T 1.0 11.0 2.0 0.916666666666667 COG2114 Adenylate_cyclase,_class_3 AcyC 12.0 0.0833333333333333 0.9166666666666666 0.509366149323246 0.110269587648696 0.309817868485971 0.39909656167455 0 0 0 1 K01770 0.0085714285714285 0.7407407407407407 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 123.0 192.0 137.0 4.0 0.644295302013423 I 3.0 295.0 2.0 0.875838926174497 COG0245 2C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase IspF 298.0 0.0100671140939597 0.9899328859060402 0.0278331721113517 0.110032551949156 0.0689328620302538 0.0821993798378043 0 0 0 0 K01771 0.0 0.037037037037037 plc; 1-phosphatidylinositol phosphodiesterase [EC:4.6.1.13] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 40.0 10.0 8.0 4.0 0.666666666666667 U 0.0 15.0 4.0 0.666666666666667 COG0823 Periplasmic_component_TolB_of_the_Tol_biopolymer_transport_system TolB 15.0 0.0 1.0 0.109810021826869 0.273219665908383 0.191514843867626 0.1634096440815139 0 0 0 0 K01772 0.0971428571428571 0.5555555555555556 hemH, FECH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 146.0 256.0 252.0 4.0 0.973384030418251 H 36.0 227.0 5.0 0.973384030418251 COG0276 Protoheme_ferro-lyase_(ferrochelatase) HemH 263.0 0.1368821292775665 0.8631178707224335 0.0009340744516084 0.0880891481349951 0.0445116112933017 0.0871550736833867 0 0 0 0 K01775 0.0114285714285714 0.8547008547008547 alr; alanine racemase [EC:5.1.1.1] path:map00470,path:map01100,path:map01502 D-Amino acid metabolism,Metabolic pathways,Vancomycin resistance 108.0 237.0 144.0 6.0 0.64054054054054 M 4.0 366.0 5.0 0.862162162162162 COG0787 Alanine_racemase Alr 370.0 0.0108108108108108 0.9891891891891892 0.231069554758854 0.0186462467407605 0.1248579007498072 0.2124233080180935 0 0 0 0 K01776 0.0542857142857142 0.7606837606837606 murI; glutamate racemase [EC:5.1.1.3] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 55.0 297.0 272.0 3.0 0.916666666666667 M 19.0 305.0 6.0 0.817901234567901 COG0796 Glutamate_racemase MurI 324.0 0.0586419753086419 0.941358024691358 0.0004031702417676 0.0054117747407395 0.0029074724912535 0.0050086044989719 0 0 0 0 K01777 0.0342857142857142 0.1111111111111111 prdF; proline racemase [EC:5.1.1.4] path:map00330,path:map00470,path:map01100 Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways 271.0 51.0 48.0 3.0 0.910714285714286 E 13.0 43.0 3.0 0.803571428571429 COG3938 Proline_racemase/hydroxyproline_epimerase PrdF 56.0 0.2321428571428571 0.7678571428571429 0.0381835536759666 0.717372086098523 0.3777778198872448 0.6791885324225564 0 0 0 0 K01778 0.2828571428571428 0.7692307692307693 dapF; diaminopimelate epimerase [EC:5.1.1.7] path:map00300,path:map00470,path:map01100,path:map01110,path:map01120,path:map01230 Lysine biosynthesis,D-Amino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 106.0 381.0 377.0 2.0 0.98961038961039 E 100.0 285.0 1.0 1.0 COG0253 Diaminopimelate_epimerase DapF 385.0 0.2597402597402597 0.7402597402597403 0.367749986298686 0.789461542338452 0.578605764318569 0.421711556039766 0 0 0 0 K01779 0.1428571428571428 0.2792022792022792 racD; aspartate racemase [EC:5.1.1.13] path:map00250,path:map00470,path:map01054,path:map01100 Alanine, aspartate and glutamate metabolism,D-Amino acid metabolism,Nonribosomal peptide structures,Metabolic pathways 88.0 184.0 179.0 4.0 0.958333333333333 M 68.0 124.0 3.0 0.989583333333333 COG1794 Amino_acid_racemase_YgeA RacX 192.0 0.3541666666666667 0.6458333333333334 0.709243143421917 0.910940276898884 0.8100917101604005 0.201697133476967 0 1 0 1 K01781 0.0 0.0313390313390313 mdlA; mandelate racemase [EC:5.1.2.2] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 319.0 12.0 0.0 1.0 1.0 M 0.0 12.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 12.0 0.0 1.0 0.0466076044798001 0.100499158563472 0.073553381521636 0.0538915540836719 0 0 0 0 K01782 0.0028571428571428 0.2735042735042735 fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] path:map00071,path:map00280,path:map00281,path:map00310,path:map00362,path:map00380,path:map00410,path:map00640,path:map00650,path:map00903,path:map00930,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,Geraniol degradation,Lysine degradation,Benzoate degradation,Tryptophan metabolism,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation,Caprolactam degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 355.0 127.0 126.0 2.0 0.9921875 I 1.0 127.0 2.0 0.8984375 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 128.0 0.0078125 0.9921875 0.0002974169025231 0.0032430795699431 0.0017702482362331 0.00294566266742 0 0 0 0 K01783 0.2628571428571428 0.9515669515669516 rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1] path:map00030,path:map00040,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Pentose and glucuronate interconversions,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 98.0 467.0 458.0 4.0 0.976987447698745 G 95.0 383.0 3.0 0.976987447698745 COG0036 Pentose-5-phosphate-3-epimerase Rpe 478.0 0.1987447698744769 0.801255230125523 0.0186368338065637 0.508818576053052 0.2637277049298078 0.4901817422464883 0 0 0 0 K01784 0.8485714285714285 0.9145299145299144 galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2] path:map00052,path:map00520,path:map00541,path:map01100,path:map01250 Galactose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 8.0 1394.0 1116.0 6.0 0.8302561048243 M 726.0 861.0 8.0 0.735556879094699 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 1587.0 0.4574669187145557 0.5425330812854442 0.153302921149078 0.153302921149078 0 0 0 0 K01785 0.08 0.4074074074074074 galM, GALM; aldose 1-epimerase [EC:5.1.3.3] path:map00010,path:map00052,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Galactose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 75.0 243.0 0.0 1.0 1.0 G 30.0 213.0 1.0 1.0 COG2017 Galactose_mutarotase_or_related_enzyme GalM 243.0 0.1234567901234567 0.8765432098765432 0.0085754721807628 0.0311872406865005 0.0198813564336316 0.0226117685057377 0 0 0 0 K01787 0.0 0.0683760683760683 RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 299.0 28.0 0.0 1.0 1.0 G 0.0 28.0 1.0 1.0 COG2942 Mannose_or_cellobiose_epimerase,_N-acyl-D-glucosamine_2-epimerase_family YihS 28.0 0.0 1.0 0.036280497594994 0.0953931526602914 0.0658368251276427 0.0591126550652974 0 0 0 0 K01788 0.0 0.1538461538461538 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 192.0 58.0 0.0 1.0 1.0 G 0.0 58.0 3.0 0.948275862068966 COG3010 Putative_N-acetylmannosamine-6-phosphate_epimerase NanE 58.0 0.0 1.0 0.0056845015395295 0.0275392691553483 0.0166118853474389 0.0218547676158188 0 0 0 0 K01790 0.3142857142857143 0.6809116809116809 rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] path:map00521,path:map00523,path:map00541,path:map01100,path:map01110,path:map01250 Streptomycin biosynthesis,Polyketide sugar unit biosynthesis,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 47.0 418.0 382.0 5.0 0.90280777537797 M 142.0 319.0 4.0 0.883369330453564 COG1898 dTDP-4-dehydrorhamnose_3,5-epimerase_or_related_enzyme RfbC 461.0 0.3080260303687636 0.6919739696312365 0.169074945644103 0.861094769125173 0.515084857384638 0.69201982348107 0 0 0 0 K01791 0.36 0.5754985754985755 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] path:map00520,path:map00541,path:map01100,path:map01250,path:map02020,path:map05111 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars,Two-component system,Biofilm formation - Vibrio cholerae 192.0 381.0 278.0 2.0 0.787190082644628 M 181.0 303.0 2.0 0.995867768595041 COG0381 UDP-N-acetylglucosamine_2-epimerase WecB 484.0 0.3739669421487603 0.6260330578512396 0.475384652043926 0.867673780650724 0.671529216347325 0.392289128606798 0 0 0 0 K01792 0.0 0.1025641025641025 E5.1.3.15; glucose-6-phosphate 1-epimerase [EC:5.1.3.15] path:map00010,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 170.0 35.0 32.0 2.0 0.921052631578947 G 0.0 38.0 3.0 0.921052631578947 COG0676 D-hexose-6-phosphate_mutarotase YeaD 38.0 0.0 1.0 0.015376680200946 0.029590703542539 0.0224836918717424 0.014214023341593 0 0 0 0 K01795 0.0028571428571428 0.0256410256410256 algG; mannuronan 5-epimerase [EC:5.1.3.37] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 317.0 9.0 8.0 2.0 0.9 P 1.0 9.0 1.0 1.0 COG3420 Nitrous_oxide_reductase_accessory_protein_NosD,_contains_tandem_CASH_domains NosD 10.0 0.1 0.9 0.0822258160044795 0.199471331073442 0.1408485735389607 0.1172455150689625 0 0 0 0 K01796 0.0028571428571428 0.1225071225071225 E5.1.99.4, AMACR, mcr; alpha-methylacyl-CoA racemase [EC:5.1.99.4] path:map00120,path:map01100,path:map04146 Primary bile acid biosynthesis,Metabolic pathways,Peroxisome 309.0 61.0 0.0 1.0 1.0 C 1.0 60.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 61.0 0.0163934426229508 0.9836065573770492 0.0242217438142865 0.171944625853061 0.0980831848336737 0.1477228820387745 0 0 0 0 K01799 0.0857142857142857 0.0911680911680911 nicE, maiA; maleate isomerase [EC:5.2.1.1] path:map00650,path:map00760,path:map01100,path:map01120 Butanoate metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 139.0 89.0 88.0 2.0 0.988888888888889 Q 37.0 53.0 1.0 1.0 COG3473 Maleate_cis-trans_isomerase 90.0 0.4111111111111111 0.5888888888888889 0.0551622383111351 0.316774491904642 0.1859683651078885 0.2616122535935069 0 0 0 0 K01800 0.0 0.0626780626780626 maiA, GSTZ1; maleylacetoacetate isomerase [EC:5.2.1.2] path:map00350,path:map00643,path:map01100,path:map01120 Tyrosine metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 198.0 19.0 15.0 2.0 0.826086956521739 O 0.0 23.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 23.0 0.0 1.0 0.0257307535876188 0.0529991371950452 0.039364945391332 0.0272683836074263 0 0 0 0 K01801 0.0 0.0712250712250712 nagL; maleylpyruvate isomerase [EC:5.2.1.4] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 181.0 24.0 19.0 2.0 0.827586206896552 O 0.0 29.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 29.0 0.0 1.0 0.0250325618404012 0.0533384704812425 0.0391855161608218 0.0283059086408413 0 0 0 0 K01802 0.8142857142857143 0.7435897435897436 E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8] 5.0 879.0 743.0 8.0 0.816155988857939 O 460.0 585.0 8.0 0.424326833797586 COG1047 Peptidyl-prolyl_cis-trans_isomerase,_FKBP_type SlpA 1045.0 0.4401913875598086 0.5598086124401914 0.0555397840120801 0.201365137352354 0.128452460682217 0.1458253533402739 0 0 0 0 K01803 0.8371428571428572 0.9886039886039886 TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1] path:map00010,path:map00051,path:map00562,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Fructose and mannose metabolism,Inositol phosphate metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 71.0 683.0 563.0 3.0 0.84634448574969 G 318.0 489.0 3.0 0.826517967781908 COG0149 Triosephosphate_isomerase TpiA 807.0 0.3940520446096654 0.6059479553903345 0.265098915203303 0.648353289275688 0.4567261022394955 0.383254374072385 0 0 0 0 K01804 0.0057142857142857 0.1424501424501424 araA; L-arabinose isomerase [EC:5.3.1.4] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 431.0 57.0 56.0 2.0 0.982758620689655 G 3.0 55.0 2.0 0.879310344827586 COG2160 L-arabinose_isomerase AraA 58.0 0.0517241379310344 0.9482758620689656 0.0169110293306734 0.327268924901209 0.1720899771159412 0.3103578955705356 0 0 0 0 K01805 0.0228571428571428 0.2678062678062678 xylA; xylose isomerase [EC:5.3.1.5] path:map00040,path:map00051,path:map01100 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways 251.0 112.0 106.0 2.0 0.949152542372881 G 9.0 109.0 3.0 0.73728813559322 COG2115 Xylose_isomerase XylA 118.0 0.0762711864406779 0.923728813559322 0.391253879642137 0.8960915989659 0.6436727393040185 0.504837719323763 0 0 0 0 K01807 0.6914285714285714 0.2849002849002849 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6] path:map00030,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 104.0 331.0 315.0 3.0 0.951149425287356 G 247.0 101.0 2.0 0.997126436781609 COG0120 Ribose_5-phosphate_isomerase RpiA 348.0 0.7097701149425287 0.2902298850574712 0.696892304252466 0.813582193733879 0.7552372489931725 0.116689889481413 0 1 0 1 K01808 0.1228571428571428 0.7094017094017094 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] path:map00030,path:map00051,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Fructose and mannose metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 82.0 353.0 345.0 3.0 0.961852861035422 G 47.0 320.0 3.0 0.948228882833788 COG0698 Ribose_5-phosphate_isomerase_RpiB RpiB 367.0 0.1280653950953678 0.8719346049046321 0.0922257122339201 0.740671484130776 0.416448598182348 0.6484457718968559 0 0 0 0 K01809 0.0457142857142857 0.4586894586894587 manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8] path:map00051,path:map00520,path:map00541,path:map01100,path:map01110,path:map01240,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Biosynthesis of nucleotide sugars 44.0 200.0 194.0 3.0 0.966183574879227 G 16.0 190.0 5.0 0.710144927536232 COG1482 Mannose-6-phosphate_isomerase,_class_I ManA 206.0 0.0776699029126213 0.9223300970873788 0.0716591106088384 0.148290105879554 0.1099746082441961 0.0766309952707156 0 0 0 0 K01810 0.2085714285714285 0.8034188034188035 GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] path:map00010,path:map00030,path:map00500,path:map00520,path:map01100,path:map01110,path:map01120,path:map01200,path:map01250 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of nucleotide sugars 164.0 363.0 339.0 4.0 0.926020408163265 G 75.0 317.0 4.0 0.969387755102041 COG0166 Glucose-6-phosphate_isomerase Pgi 392.0 0.1913265306122449 0.8086734693877551 0.019064805173235 0.0539359409936429 0.0365003730834389 0.0348711358204079 0 0 0 0 K01811 0.0371428571428571 0.1538461538461538 xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] 299.0 102.0 0.0 1.0 1.0 G 17.0 83.0 2.0 0.990196078431373 COG1501 Alpha-glucosidase/xylosidase,_GH31_family YicI 100.0 0.17 0.83 0.134260680612553 0.595843884489769 0.365052282551161 0.4615832038772159 0 0 0 0 K01812 0.0428571428571428 0.2279202279202279 uxaC; glucuronate isomerase [EC:5.3.1.12] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 205.0 95.0 70.0 3.0 0.778688524590164 G 19.0 103.0 4.0 0.688524590163934 COG1904 Glucuronate_isomerase UxaC 122.0 0.1557377049180328 0.8442622950819673 0.0529368403632439 0.127355317596691 0.0901460789799674 0.0744184772334471 0 0 0 0 K01813 0.0 0.0712250712250712 rhaA; L-rhamnose isomerase [EC:5.3.1.14] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 404.0 27.0 26.0 2.0 0.964285714285714 G 0.0 28.0 2.0 0.964285714285714 COG4806 L-rhamnose_isomerase RhaA 28.0 0.0 1.0 0.0230392348247926 0.0991489915057164 0.0610941131652545 0.0761097566809238 0 0 0 0 K01814 0.52 0.7606837606837606 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 65.0 513.0 501.0 10.0 0.927667269439421 E 242.0 311.0 11.0 0.804701627486438 COG0106 Phosphoribosylformimino-5-aminoimidazole_carboxamide_ribonucleotide_(ProFAR)_isomerase HisA 553.0 0.4376130198915009 0.5623869801084991 0.109662096915712 0.581129236373596 0.345395666644654 0.471467139457884 0 0 0 0 K01815 0.0 0.131054131054131 kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 260.0 49.0 0.0 1.0 1.0 G 0.0 49.0 1.0 1.0 COG3717 5-keto_4-deoxyuronate_isomerase KduI 49.0 0.0 1.0 0.0073077541179816 0.0392884513112541 0.0232981027146178 0.0319806971932725 0 0 0 0 K01816 0.0457142857142857 0.1851851851851851 hyi, gip; hydroxypyruvate isomerase [EC:5.3.1.22] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 128.0 115.0 0.0 1.0 1.0 G 16.0 99.0 2.0 0.88695652173913 COG3622 Hydroxypyruvate/dehydroerythronate_isomerase,_Hyi/OtnI_family Hyi 115.0 0.1391304347826087 0.8608695652173913 0.0120619628554026 0.259202331676763 0.1356321472660828 0.2471403688213604 0 0 0 0 K01817 0.42 0.7207977207977208 trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 31.0 467.0 454.0 3.0 0.970893970893971 E 155.0 326.0 4.0 0.83991683991684 COG0135 Phosphoribosylanthranilate_isomerase TrpF 481.0 0.3222453222453222 0.6777546777546778 0.048354305160962 0.249570443758718 0.14896237445984 0.201216138597756 0 0 0 0 K01818 0.0085714285714285 0.0911680911680911 fucI; L-fucose/D-arabinose isomerase [EC:5.3.1.25 5.3.1.3] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 442.0 37.0 0.0 1.0 1.0 G 3.0 34.0 1.0 1.0 COG2407 L-fucose_isomerase_or_related_protein FucI 37.0 0.081081081081081 0.918918918918919 0.70245524670816 0.545700834006489 0.6240780403573245 0.1567544127016709 0 0 0 1 K01819 0.0114285714285714 0.037037037037037 E5.3.1.26, lacA, lacB; galactose-6-phosphate isomerase [EC:5.3.1.26] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 130.0 29.0 0.0 1.0 1.0 G 4.0 25.0 1.0 1.0 COG0698 Ribose_5-phosphate_isomerase_RpiB RpiB 29.0 0.1379310344827586 0.8620689655172413 0.0223274103321383 0.17681713456099 0.0995722724465641 0.1544897242288516 0 0 0 0 K01820 0.0 0.1168091168091168 rhaA; L-rhamnose isomerase / sugar isomerase [EC:5.3.1.14 5.3.1.-] path:map00040,path:map00051,path:map01100,path:map01120 Pentose and glucuronate interconversions,Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 364.0 33.0 24.0 2.0 0.785714285714286 M 0.0 42.0 1.0 1.0 COG4952 L-rhamnose_isomerase 42.0 0.0 1.0 0.220851841680679 0.0202003143608555 0.1205260780207672 0.2006515273198235 0 0 0 0 K01821 0.18 0.2478632478632478 praC, xylH; 4-oxalocrotonate tautomerase [EC:5.3.2.6] path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 41.0 154.0 123.0 2.0 0.832432432432432 S 72.0 113.0 3.0 0.65945945945946 COG1942 Phenylpyruvate_tautomerase_PptA,_4-oxalocrotonate_tautomerase_family PptA 185.0 0.3891891891891892 0.6108108108108108 0.143743718011496 0.747556230284603 0.4456499741480495 0.6038125122731071 0 0 0 0 K01822 0.0028571428571428 0.0569800569800569 E5.3.3.1; steroid Delta-isomerase [EC:5.3.3.1] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 63.0 21.0 0.0 1.0 1.0 S 1.0 26.0 2.0 0.62962962962963 COG3631 Ketosteroid_isomerase-related_protein YesE 27.0 0.037037037037037 0.9629629629629628 0.0119514377411797 0.024373203187403 0.0181623204642913 0.0124217654462233 0 0 0 0 K01823 0.7514285714285714 0.358974358974359 idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 55.0 219.0 74.0 5.0 0.484513274336283 H 313.0 137.0 5.0 0.615044247787611 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 450.0 0.6955555555555556 0.3044444444444444 0.0616808578054742 0.118784208345753 0.0902325330756136 0.0571033505402788 0 0 0 0 K01825 0.0 0.0655270655270655 fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] path:map00071,path:map00280,path:map00281,path:map00310,path:map00362,path:map00380,path:map00410,path:map00640,path:map00650,path:map00903,path:map00930,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,Geraniol degradation,Lysine degradation,Benzoate degradation,Tryptophan metabolism,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Limonene and pinene degradation,Caprolactam degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 614.0 24.0 0.0 1.0 1.0 I 0.0 24.0 2.0 0.916666666666667 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 24.0 0.0 1.0 0.0058033110190289 0.0375998884826319 0.0217015997508304 0.0317965774636029 0 0 0 0 K01826 0.0114285714285714 0.0968660968660968 hpaF, hpcD; 5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10] path:map00350,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 72.0 25.0 12.0 3.0 0.555555555555556 Q 5.0 40.0 2.0 0.577777777777778 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 45.0 0.1111111111111111 0.8888888888888888 0.1804188655792 0.0111327800382191 0.0957758228087095 0.1692860855409809 0 0 0 0 K01829 0.0028571428571428 0.1424501424501424 dsbH; disulfide reductase [EC:1.8.-.-] 21.0 22.0 1.0 5.0 0.360655737704918 CO 1.0 60.0 6.0 0.360655737704918 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 61.0 0.0163934426229508 0.9836065573770492 0.0126082906933235 0.188652355675336 0.1006303231843297 0.1760440649820125 0 0 0 0 K01834 0.2142857142857142 0.4188034188034188 PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] path:map00010,path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map04922,path:map05230 Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Glucagon signaling pathway,Central carbon metabolism in cancer 85.0 264.0 236.0 4.0 0.897959183673469 G 80.0 214.0 3.0 0.663265306122449 COG0588 Phosphoglycerate_mutase_(BPG-dependent) GpmA 294.0 0.272108843537415 0.7278911564625851 0.0441462019988187 0.0725188563498707 0.0583325291743447 0.0283726543510519 0 0 0 0 K01835 0.0371428571428571 0.6068376068376068 pgm; phosphoglucomutase [EC:5.4.2.2] path:map00010,path:map00030,path:map00052,path:map00230,path:map00500,path:map00520,path:map00521,path:map01100,path:map01110,path:map01120,path:map01250 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Galactose metabolism,Purine metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Streptomycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of nucleotide sugars 206.0 283.0 282.0 2.0 0.996478873239437 G 13.0 271.0 2.0 0.665492957746479 COG1109 Phosphomannomutase ManB 284.0 0.0457746478873239 0.954225352112676 0.309963352611995 0.511228472735268 0.4105959126736315 0.2012651201232729 0 0 0 0 K01838 0.1028571428571428 0.245014245014245 pgmB; beta-phosphoglucomutase [EC:5.4.2.6] path:map00500 Starch and sucrose metabolism 56.0 134.0 125.0 4.0 0.905405405405405 S 42.0 106.0 2.0 0.97972972972973 COG0637 Beta-phosphoglucomutase,_HAD_superfamily YcjU 148.0 0.2837837837837837 0.7162162162162162 0.0256128173436497 0.591375815421358 0.3084943163825038 0.5657629980777082 0 0 0 0 K01839 0.0 0.2706552706552707 deoB; phosphopentomutase [EC:5.4.2.7] path:map00030,path:map00230,path:map01100 Pentose phosphate pathway,Purine metabolism,Metabolic pathways 325.0 94.0 86.0 2.0 0.92156862745098 G 0.0 102.0 1.0 1.0 COG1015 Phosphopentomutase DeoB 102.0 0.0 1.0 0.605936337784527 0.612647131409929 0.609291734597228 0.0067107936254019 0 0 0 1 K01840 0.2885714285714286 0.7492877492877493 manB; phosphomannomutase [EC:5.4.2.8] path:map00051,path:map00520,path:map00541,path:map01100,path:map01110,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 93.0 466.0 455.0 7.0 0.937625754527163 G 120.0 376.0 4.0 0.957746478873239 COG1109 Phosphomannomutase ManB 496.0 0.2419354838709677 0.7580645161290323 0.09684973767261 0.698777277718534 0.397813507695572 0.6019275400459241 0 0 0 0 K01841 0.0685714285714285 0.0854700854700854 pepM; phosphoenolpyruvate phosphomutase [EC:5.4.2.9] path:map00440,path:map00998,path:map01100,path:map01110,path:map01120 Phosphonate and phosphinate metabolism,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 185.0 30.0 21.0 9.0 0.508474576271186 G 27.0 32.0 4.0 0.491525423728814 COG2513 2-Methylisocitrate_lyase_and_related_enzymes,_PEP_mutase_family PrpB 59.0 0.4576271186440678 0.5423728813559322 0.785065229983712 0.343327299921492 0.564196264952602 0.4417379300622199 1 1 1 1 K01843 0.14 0.3219373219373219 kamA; lysine 2,3-aminomutase [EC:5.4.3.2] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 195.0 133.0 68.0 3.0 0.624413145539906 E 59.0 154.0 2.0 0.995305164319249 COG1509 L-lysine_2,3-aminomutase_(EF-P_beta-lysylation_pathway) EpmB 213.0 0.2769953051643192 0.7230046948356808 0.310120839777973 0.533014413016886 0.4215676263974295 0.222893573238913 0 0 0 0 K01844 0.0057142857142857 0.0683760683760683 kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3] path:map00310,path:map00470,path:map01100 Lysine degradation,D-Amino acid metabolism,Metabolic pathways 488.0 27.0 0.0 1.0 1.0 F 2.0 25.0 1.0 1.0 COG0274 Deoxyribose-phosphate_aldolase DeoC 27.0 0.074074074074074 0.925925925925926 0.162975053167287 0.714918386383027 0.438946719775157 0.55194333321574 0 0 0 0 K01845 0.5428571428571428 0.6495726495726496 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 220.0 589.0 584.0 6.0 0.971947194719472 H 264.0 342.0 3.0 0.983498349834984 COG0001 Glutamate-1-semialdehyde_aminotransferase HemL 606.0 0.4356435643564356 0.5643564356435643 0.525565087846669 0.938120117692246 0.7318426027694576 0.412555029845577 0 1 0 1 K01846 0.0428571428571428 0.0427350427350427 glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1] path:map00630,path:map00660,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 129.0 37.0 35.0 2.0 0.948717948717949 I 22.0 17.0 2.0 0.974358974358975 COG2185 Methylmalonyl-CoA_mutase,_C-terminal_domain/subunit_(cobalamin-binding) Sbm 39.0 0.5641025641025641 0.4358974358974359 0.0154602956678532 0.0740672198948239 0.0447637577813385 0.0586069242269707 0 0 0 0 K01847 0.0742857142857142 0.3418803418803419 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 363.0 219.0 0.0 1.0 1.0 I 28.0 190.0 3.0 0.91324200913242 COG1884 Methylmalonyl-CoA_mutase,_N-terminal_domain/subunit Sbm 218.0 0.128440366972477 0.8715596330275229 0.112092936336152 0.0351965899670376 0.0736447631515948 0.0768963463691144 0 0 0 0 K01848 0.3714285714285714 0.2735042735042735 E5.4.99.2A, mcmA1; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 461.0 328.0 318.0 2.0 0.970414201183432 I 196.0 142.0 2.0 0.970414201183432 COG1884 Methylmalonyl-CoA_mutase,_N-terminal_domain/subunit Sbm 338.0 0.5798816568047337 0.4201183431952662 0.0201445836610068 0.438082699648176 0.2291136416545914 0.4179381159871692 0 0 0 0 K01849 0.36 0.2364672364672364 E5.4.99.2B, mcmA2; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 101.0 251.0 247.0 3.0 0.976653696498054 I 149.0 108.0 3.0 0.972762645914397 COG2185 Methylmalonyl-CoA_mutase,_C-terminal_domain/subunit_(cobalamin-binding) Sbm 257.0 0.5797665369649806 0.4202334630350194 0.0827604653889074 0.81096024913263 0.4468603572607686 0.7281997837437226 0 0 0 0 K01850 0.0028571428571428 0.0028490028490028 E5.4.99.5; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 156.0 2.0 0.0 1.0 1.0 E 1.0 1.0 1.0 1.0 COG1605 Chorismate_mutase PheA 2.0 0.5 0.5 0 0 0 0 K01851 0.0 0.0256410256410256 pchA; salicylate biosynthesis isochorismate synthase [EC:5.4.4.2] path:map00130,path:map01053,path:map01100,path:map01110 Ubiquinone and other terpenoid-quinone biosynthesis,Biosynthesis of siderophore group nonribosomal peptides,Metabolic pathways,Biosynthesis of secondary metabolites 369.0 9.0 7.0 2.0 0.818181818181818 HQ 0.0 11.0 1.0 1.0 COG1169 Isochorismate_synthase_EntC MenF 11.0 0.0 1.0 0.0281378762973149 0.0810170740028648 0.0545774751500898 0.0528791977055499 0 0 0 0 K01852 0.0 0.0085470085470085 LSS, ERG7; lanosterol synthase [EC:5.4.99.7] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 620.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG1657 Terpene_cyclase_SqhC SqhC 3.0 0.0 1.0 0 0 0 0 K01854 0.0371428571428571 0.2336182336182336 glf; UDP-galactopyranose mutase [EC:5.4.99.9] path:map00052,path:map00520,path:map00541,path:map01100,path:map01250 Galactose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 180.0 70.0 43.0 6.0 0.648148148148148 M 16.0 92.0 4.0 0.638888888888889 COG0562 UDP-galactopyranose_mutase Glf 108.0 0.1481481481481481 0.8518518518518519 0.0088287817734115 0.0176318314422895 0.0132303066078505 0.008803049668878 0 0 0 0 K01856 0.0114285714285714 0.1025641025641025 catB; muconate cycloisomerase [EC:5.5.1.1] path:map00361,path:map00362,path:map00364,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Fluorobenzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 241.0 40.0 35.0 3.0 0.851063829787234 M 4.0 43.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 47.0 0.0851063829787234 0.9148936170212766 0.0287005029221536 0.058041299530606 0.0433709012263798 0.0293407966084524 0 0 0 0 K01857 0.0085714285714285 0.1339031339031339 pcaB; 3-carboxy-cis,cis-muconate cycloisomerase [EC:5.5.1.2] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 350.0 68.0 0.0 1.0 1.0 F 3.0 65.0 1.0 1.0 COG0015 Adenylosuccinate_lyase PurB 68.0 0.0441176470588235 0.9558823529411764 0.110994141007032 0.607435380653726 0.359214760830379 0.496441239646694 0 0 0 0 K01858 0.48 0.2364672364672364 INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] path:map00521,path:map00562,path:map01100,path:map01110 Streptomycin biosynthesis,Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 274.0 311.0 310.0 3.0 0.993610223642173 I 218.0 95.0 2.0 0.993610223642173 COG1260 Myo-inositol-1-phosphate_synthase INO1 313.0 0.6964856230031949 0.3035143769968051 0.337491537747748 0.579855784247641 0.4586736609976944 0.2423642464998929 0 0 0 0 K01860 0.0 0.017094017094017 E5.5.1.7; chloromuconate cycloisomerase [EC:5.5.1.7] path:map00361,path:map00364,path:map00623,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Fluorobenzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments 359.0 6.0 4.0 2.0 0.75 M 0.0 8.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 8.0 0.0 1.0 0.0472491465970106 0.0568311346966369 0.0520401406468237 0.0095819880996263 0 0 0 0 K01865 0.0 0.0085470085470085 hab; (hydroxyamino)benzene mutase [EC:5.4.4.1] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 147.0 0.0 3.0 1.0 1.0 2C945 3.0 0.0 1.0 0 0 0 0 K01866 0.9028571428571428 0.9715099715099716 YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1] path:map00970 Aminoacyl-tRNA biosynthesis 177.0 688.0 685.0 2.0 0.995658465991317 J 337.0 354.0 3.0 0.979739507959479 COG0162 Tyrosyl-tRNA_synthetase TyrS 691.0 0.487698986975398 0.5123010130246021 0.94431820732603 0.415970289484636 0.680144248405333 0.528347917841394 1 1 1 1 K01867 0.8485714285714285 0.9715099715099716 WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] path:map00970 Aminoacyl-tRNA biosynthesis 136.0 696.0 687.0 2.0 0.987234042553192 J 339.0 366.0 2.0 0.987234042553192 COG0180 Tryptophanyl-tRNA_synthetase TrpS 705.0 0.4808510638297872 0.5191489361702127 0.862104347495924 0.628720562023185 0.7454124547595545 0.2333837854727389 1 1 1 1 K01868 0.8971428571428571 0.9743589743589745 TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3] path:map00970 Aminoacyl-tRNA biosynthesis 235.0 732.0 731.0 2.0 0.998635743519782 J 365.0 368.0 4.0 0.994542974079127 COG0441 Threonyl-tRNA_synthetase ThrS 733.0 0.4979536152796726 0.5020463847203275 0.616856172142595 0.963490810426707 0.790173491284651 0.346634638284112 0 1 0 1 K01869 0.8742857142857143 0.9772079772079773 LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4] path:map00970 Aminoacyl-tRNA biosynthesis 316.0 712.0 0.0 1.0 1.0 J 343.0 366.0 3.0 0.957865168539326 COG0495 Leucyl-tRNA_synthetase LeuS 709.0 0.4837799717912553 0.5162200282087447 0.923671640428994 0.857235290029042 0.8904534652290179 0.066436350399952 1 1 1 1 K01870 0.9114285714285716 0.9829059829059827 IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5] path:map00970 Aminoacyl-tRNA biosynthesis 374.0 721.0 0.0 1.0 1.0 J 340.0 376.0 1.0 1.0 COG0060 Isoleucyl-tRNA_synthetase IleS 716.0 0.4748603351955307 0.5251396648044693 0.824806015544701 0.35310997480862 0.5889579951766605 0.471696040736081 1 1 1 1 K01872 0.9342857142857144 0.9544159544159544 AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7] path:map00970 Aminoacyl-tRNA biosynthesis 81.0 872.0 845.0 2.0 0.969966629588432 J 485.0 400.0 2.0 0.957730812013348 COG0013 Alanyl-tRNA_synthetase AlaS 885.0 0.5480225988700564 0.4519774011299435 0.174953695105343 0.869332648176663 0.522143171641003 0.69437895307132 0 0 0 0 K01873 0.8942857142857142 0.9857549857549858 VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9] path:map00970 Aminoacyl-tRNA biosynthesis 375.0 698.0 0.0 1.0 1.0 J 327.0 371.0 2.0 0.951289398280802 COG0525 Valyl-tRNA_synthetase ValS 698.0 0.4684813753581662 0.5315186246418339 0.962485101327261 0.974279517882202 0.9683823096047316 0.011794416554941 1 1 1 1 K01874 0.8885714285714286 0.9914529914529916 MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10] path:map00450,path:map00970,path:map01100 Selenocompound metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways 211.0 781.0 780.0 2.0 0.998721227621483 J 339.0 381.0 3.0 0.70076726342711 COG0143 Methionyl-tRNA_synthetase MetG 720.0 0.4708333333333333 0.5291666666666667 0.0289715414701034 0.0092838618838264 0.0191277016769649 0.019687679586277 0 0 0 0 K01875 0.9057142857142856 0.9772079772079773 SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11] path:map00970 Aminoacyl-tRNA biosynthesis 266.0 678.0 677.0 2.0 0.998527245949926 J 324.0 355.0 1.0 1.0 COG0172 Seryl-tRNA_synthetase SerS 679.0 0.4771723122238586 0.5228276877761414 0.372514031241284 0.928431500249988 0.650472765745636 0.555917469008704 0 0 0 0 K01876 0.1314285714285714 0.9829059829059827 DARS2, aspS; aspartyl-tRNA synthetase [EC:6.1.1.12] path:map00970 Aminoacyl-tRNA biosynthesis 314.0 441.0 415.0 2.0 0.944325481798715 J 51.0 416.0 4.0 0.813704496788009 COG0173 Aspartyl-tRNA_synthetase AspS 467.0 0.1092077087794432 0.8907922912205567 0.0041412147920697 0.694459496046503 0.3493003554192864 0.6903182812544333 0 0 0 0 K01878 0.0 0.4786324786324786 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] path:map00970 Aminoacyl-tRNA biosynthesis 274.0 170.0 0.0 1.0 1.0 J 0.0 170.0 1.0 1.0 COG0752 Glycyl-tRNA_synthetase,_alpha_subunit GlyQ 170.0 0.0 1.0 0.282707271855871 0.137677828623922 0.2101925502398965 0.145029443231949 0 0 0 0 K01879 0.0 0.4957264957264957 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] path:map00970 Aminoacyl-tRNA biosynthesis 390.0 178.0 174.0 2.0 0.978021978021978 J 0.0 182.0 2.0 0.978021978021978 COG0751 Glycyl-tRNA_synthetase,_beta_subunit GlyS 182.0 0.0 1.0 0.972315154970602 0.176082193108824 0.5741986740397129 0.7962329618617779 0 0 1 1 K01880 0.8942857142857142 0.4643874643874643 GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14] path:map00970 Aminoacyl-tRNA biosynthesis 285.0 490.0 0.0 1.0 1.0 J 321.0 169.0 1.0 1.0 COG0423 Glycyl-tRNA_synthetase,_class_II GRS1 490.0 0.6551020408163265 0.3448979591836735 0.855878345882375 0.882918219276928 0.8693982825796516 0.027039873394553 1 1 1 1 K01881 0.9 0.9886039886039886 PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15] path:map00970 Aminoacyl-tRNA biosynthesis 203.0 704.0 0.0 1.0 1.0 J 331.0 371.0 3.0 0.576704545454545 COG0442 Prolyl-tRNA_synthetase ProS 702.0 0.4715099715099715 0.5284900284900285 0.345495234071305 0.788275920090785 0.566885577081045 0.4427806860194799 0 0 0 0 K01883 0.8142857142857143 0.9886039886039886 CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16] path:map00970 Aminoacyl-tRNA biosynthesis 210.0 715.0 706.0 5.0 0.974114441416894 J 318.0 416.0 3.0 0.950953678474114 COG0215 Cysteinyl-tRNA_synthetase CysS 734.0 0.4332425068119891 0.5667574931880109 0.0168167246551909 0.921680619910408 0.4692486722827994 0.904863895255217 0 0 0 0 K01884 0.0257142857142857 0.0455840455840455 cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16] path:map00970 Aminoacyl-tRNA biosynthesis 95.0 22.0 18.0 2.0 0.846153846153846 G 13.0 16.0 3.0 0.6875 COG2342 Endo_alpha-1,4_polygalactosaminidase,_GH114_family_(was_erroneously_annotated_as_Cys-tRNA_synthetase) 29.0 0.4482758620689655 0.5517241379310345 0.621669570890458 0.82779286928314 0.724731220086799 0.2061232983926819 0 1 0 1 K01885 0.9285714285714286 0.9373219373219374 EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17] path:map00860,path:map00970,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 139.0 765.0 760.0 2.0 0.993506493506493 J 334.0 436.0 2.0 0.993506493506494 COG0008 Glutamyl-_or_glutaminyl-tRNA_synthetase GlnS 770.0 0.4337662337662337 0.5662337662337662 0.0435957499839994 0.227390659428911 0.1354932047064552 0.1837949094449116 0 0 0 0 K01886 0.0085714285714285 0.4102564102564102 QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 507.0 150.0 0.0 1.0 1.0 J 3.0 147.0 1.0 1.0 COG0008 Glutamyl-_or_glutaminyl-tRNA_synthetase GlnS 150.0 0.02 0.98 0.0901623808230766 0.0615127119734831 0.0758375463982798 0.0286496688495934 0 0 0 0 K01887 0.8885714285714286 0.98005698005698 RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19] path:map00970 Aminoacyl-tRNA biosynthesis 194.0 692.0 0.0 1.0 1.0 J 319.0 373.0 1.0 1.0 COG0018 Arginyl-tRNA_synthetase ArgS 692.0 0.4609826589595375 0.5390173410404624 0.797501390598884 0.893414771429034 0.845458081013959 0.09591338083015 1 1 1 1 K01889 0.8942857142857142 0.9857549857549858 FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] path:map00970 Aminoacyl-tRNA biosynthesis 169.0 678.0 0.0 1.0 1.0 J 323.0 355.0 3.0 0.988200589970501 COG0016 Phenylalanyl-tRNA_synthetase_alpha_subunit PheS 678.0 0.4764011799410029 0.523598820058997 0.435126222280342 0.961235892610401 0.6981810574453715 0.526109670330059 0 0 0 0 K01890 0.8971428571428571 0.9715099715099716 FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] path:map00970 Aminoacyl-tRNA biosynthesis 148.0 714.0 0.0 1.0 1.0 J 345.0 367.0 2.0 0.964985994397759 COG0072 Phenylalanyl-tRNA_synthetase_beta_subunit PheT 712.0 0.4845505617977528 0.5154494382022472 0.764802103418101 0.197346600489064 0.4810743519535825 0.5674555029290369 1 1 1 1 K01892 0.9 0.9914529914529916 HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21] path:map00970 Aminoacyl-tRNA biosynthesis 116.0 723.0 715.0 3.0 0.987704918032787 J 335.0 397.0 6.0 0.956284153005464 COG0124 Histidyl-tRNA_synthetase HisS 732.0 0.4576502732240437 0.5423497267759563 0.732233621179373 0.611952317670266 0.6720929694248194 0.1202813035091069 0 1 0 1 K01893 0.3828571428571428 0.49002849002849 NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22] path:map00970 Aminoacyl-tRNA biosynthesis 240.0 397.0 394.0 2.0 0.9925 J 217.0 183.0 2.0 0.9925 COG0017 Aspartyl/asparaginyl-tRNA_synthetase AsnS 400.0 0.5425 0.4575 0.96875037395207 0.444048918202478 0.706399646077274 0.5247014557495919 1 1 1 1 K01894 0.0 0.168091168091168 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-] 189.0 61.0 0.0 1.0 1.0 J 0.0 61.0 1.0 1.0 COG0008 Glutamyl-_or_glutaminyl-tRNA_synthetase GlnS 61.0 0.0 1.0 0.0222509815913988 0.0240147977879685 0.0231328896896836 0.0017638161965696 0 0 0 0 K01895 0.6 0.6666666666666666 ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1] path:map00010,path:map00620,path:map00630,path:map00640,path:map00680,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 302.0 846.0 799.0 6.0 0.911637931034483 I 516.0 412.0 5.0 0.992456896551724 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 928.0 0.5560344827586207 0.4439655172413793 0.107514154741334 0.664998254322025 0.3862562045316794 0.557484099580691 0 0 0 0 K01896 0.0028571428571428 0.0227920227920227 ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 536.0 9.0 0.0 1.0 1.0 I 1.0 8.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 9.0 0.1111111111111111 0.8888888888888888 0.0051235059551095 0.0161312941639266 0.010627400059518 0.0110077882088171 0 0 0 0 K01897 0.4085714285714286 0.7663817663817664 ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3] path:map00061,path:map00071,path:map01100,path:map01212,path:map02024,path:map03320,path:map04146,path:map04216,path:map04714,path:map04920 Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways,Fatty acid metabolism,Quorum sensing,PPAR signaling pathway,Peroxisome,Ferroptosis,Thermogenesis,Adipocytokine signaling pathway 25.0 550.0 19.0 6.0 0.502742230347349 I 309.0 770.0 10.0 0.611517367458867 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 1079.0 0.2863762743280815 0.7136237256719185 0.0020344974266444 0.102440725650254 0.0522376115384492 0.1004062282236096 0 0 0 0 K01899 0.0028571428571428 0.0 LSC1; succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5] path:map00020,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 729.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 1.0 1.0 0.0 0 0 0 0 K01902 0.4914285714285714 0.6524216524216524 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] path:map00020,path:map00640,path:map00660,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Propanoate metabolism,C5-Branched dibasic acid metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 199.0 432.0 421.0 3.0 0.966442953020134 C 186.0 261.0 2.0 0.995525727069351 COG0074 Succinyl-CoA_synthetase,_alpha_subunit SucD 447.0 0.4161073825503356 0.5838926174496645 0.501294712082026 0.270368985195901 0.3858318486389635 0.230925726886125 0 1 0 1 K01903 0.4971428571428571 0.6410256410256411 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] path:map00020,path:map00640,path:map00660,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Propanoate metabolism,C5-Branched dibasic acid metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 253.0 330.0 230.0 3.0 0.765661252900232 C 182.0 249.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 431.0 0.4222737819025522 0.5777262180974478 0.560941921842992 0.842856874380276 0.7018993981116339 0.281914952537284 0 1 0 1 K01904 0.0028571428571428 0.0142450142450142 4CL; 4-coumarate--CoA ligase [EC:6.2.1.12] path:map00130,path:map00940,path:map01100,path:map01110 Ubiquinone and other terpenoid-quinone biosynthesis,Phenylpropanoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 482.0 6.0 0.0 1.0 1.0 IQ 1.0 5.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 6.0 0.1666666666666666 0.8333333333333334 0.020660766617901 0.138044781984981 0.079352774301441 0.1173840153670799 0 0 0 0 K01905 0.5628571428571428 0.1452991452991453 acdA; acetate---CoA ligase (ADP-forming) subunit alpha [EC:6.2.1.13] path:map00010,path:map00620,path:map00640,path:map01100,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Propanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 218.0 468.0 464.0 4.0 0.981132075471698 C 365.0 102.0 4.0 0.689727463312369 COG1042 Acyl-CoA_synthetase_(NDP_forming) PatZN 467.0 0.7815845824411135 0.2184154175588865 0.829086260318009 0.930573510734563 0.879829885526286 0.1014872504165539 1 1 1 1 K01906 0.0142857142857142 0.0911680911680911 bioW; 6-carboxyhexanoate--CoA ligase [EC:6.2.1.14] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 138.0 25.0 8.0 2.0 0.595238095238095 H 6.0 36.0 2.0 0.595238095238095 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 42.0 0.1428571428571428 0.8571428571428571 0.0150367761529218 0.428696212058016 0.2218664941054689 0.4136594359050942 0 0 0 0 K01907 0.08 0.1851851851851851 AACS, acsA; acetoacetyl-CoA synthetase [EC:6.2.1.16] path:map00280,path:map00650,path:map01100 Valine, leucine and isoleucine degradation,Butanoate metabolism,Metabolic pathways 537.0 99.0 97.0 3.0 0.961165048543689 I 32.0 71.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 103.0 0.3106796116504854 0.6893203883495146 0.130673003720947 0.831219736539261 0.480946370130104 0.7005467328183139 0 0 0 0 K01908 0.0171428571428571 0.1737891737891738 ACSS3, prpE; propionyl-CoA synthetase [EC:6.2.1.17] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 577.0 72.0 71.0 2.0 0.986301369863014 I 6.0 67.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 73.0 0.0821917808219178 0.9178082191780822 0.0567590403282073 0.860925958137765 0.4588424992329861 0.8041669178095576 0 0 0 0 K01909 0.0 0.0142450142450142 mbtM; long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20] path:map00071 Fatty acid degradation 33.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 3.0 0.333333333333333 COG0236 Acyl_carrier_protein AcpP 6.0 0.0 1.0 0.0070707838564059 0.0244155246759133 0.0157431542661596 0.0173447408195073 0 0 0 0 K01910 0.0028571428571428 0.037037037037037 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22] path:map02020 Two-component system 312.0 11.0 3.0 2.0 0.578947368421053 H 1.0 18.0 1.0 1.0 COG3053 Citrate_lyase_synthetase_CitC CitC 19.0 0.0526315789473684 0.9473684210526316 0.0766382896803777 0.375217701174123 0.2259279954272503 0.2985794114937453 0 0 0 0 K01911 0.1228571428571428 0.3076923076923077 menE; o-succinylbenzoate---CoA ligase [EC:6.2.1.26] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 203.0 101.0 60.0 5.0 0.651612903225806 IQ 44.0 111.0 3.0 0.980645161290322 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 155.0 0.2838709677419355 0.7161290322580646 0.0004221311489597 0.0045166701811157 0.0024694006650377 0.004094539032156 0 0 0 0 K01912 0.3514285714285714 0.49002849002849 paaK; phenylacetate-CoA ligase [EC:6.2.1.30] path:map00360,path:map01100,path:map01120,path:map05111 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biofilm formation - Vibrio cholerae 73.0 587.0 578.0 3.0 0.978333333333333 H 272.0 328.0 6.0 0.97 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 600.0 0.4533333333333333 0.5466666666666666 0.128115678129477 0.336384142701427 0.232249910415452 0.20826846457195 0 0 0 0 K01914 0.0142857142857142 0.1168091168091168 asnA; aspartate--ammonia ligase [EC:6.3.1.1] path:map00250,path:map00460,path:map01100,path:map01110,path:map01230 Alanine, aspartate and glutamate metabolism,Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 314.0 43.0 37.0 2.0 0.877551020408163 E 5.0 44.0 1.0 1.0 COG2502 Asparagine_synthetase_A AsnA 49.0 0.1020408163265306 0.8979591836734694 0.0980335879396079 0.106484912458114 0.1022592501988609 0.0084513245185061 0 0 0 0 K01915 0.6971428571428572 0.8547008547008547 glnA, GLUL; glutamine synthetase [EC:6.3.1.2] path:map00220,path:map00250,path:map00630,path:map00910,path:map01100,path:map01120,path:map01230,path:map02020,path:map04217,path:map04724,path:map04727 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Glyoxylate and dicarboxylate metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of amino acids,Two-component system,Necroptosis,Glutamatergic synapse,GABAergic synapse 163.0 797.0 705.0 5.0 0.847872340425532 E 327.0 613.0 4.0 0.896808510638298 COG0174 Glutamine_synthetase GlnA 940.0 0.3478723404255319 0.652127659574468 0.85503330696057 0.955553384293176 0.905293345626873 0.100520077332606 1 1 1 1 K01916 0.6885714285714286 0.5470085470085471 nadE; NAD+ synthase [EC:6.3.1.5] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 100.0 460.0 426.0 4.0 0.909090909090909 H 289.0 217.0 4.0 0.984189723320158 COG0171 NH3-dependent_NAD+_synthetase NadE 506.0 0.5711462450592886 0.4288537549407115 0.571633587133113 0.844972062752555 0.708302824942834 0.273338475619442 0 1 0 1 K01918 0.0028571428571428 0.6923076923076923 panC; pantoate--beta-alanine ligase [EC:6.3.2.1] path:map00410,path:map00770,path:map01100,path:map01110,path:map01240 beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 156.0 250.0 248.0 4.0 0.984251968503937 H 1.0 253.0 3.0 0.988188976377953 COG0414 Panthothenate_synthetase PanC 254.0 0.0039370078740157 0.9960629921259844 0.0088879332407263 0.715831774773122 0.3623598540069241 0.7069438415323956 0 0 0 0 K01919 0.0371428571428571 0.3618233618233618 gshA; glutamate--cysteine ligase [EC:6.3.2.2] path:map00270,path:map00480,path:map01100,path:map01240 Cysteine and methionine metabolism,Glutathione metabolism,Metabolic pathways,Biosynthesis of cofactors 23.0 101.0 76.0 7.0 0.639240506329114 H 14.0 140.0 8.0 0.424050632911392 COG3572 Gamma-glutamylcysteine_synthetase Gsh2 154.0 0.0909090909090909 0.9090909090909092 0.0161113225802154 0.0679510685794468 0.0420311955798311 0.0518397459992314 0 0 0 0 K01920 0.0285714285714285 0.2706552706552707 gshB; glutathione synthase [EC:6.3.2.3] path:map00270,path:map00480,path:map01100,path:map01240 Cysteine and methionine metabolism,Glutathione metabolism,Metabolic pathways,Biosynthesis of cofactors 202.0 86.0 63.0 4.0 0.767857142857143 H 11.0 101.0 3.0 0.928571428571429 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 112.0 0.0982142857142857 0.9017857142857144 0.0059979147139261 0.0389263544663672 0.0224621345901466 0.0329284397524411 0 0 0 0 K01921 0.14 0.9316239316239316 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] path:map00470,path:map00550,path:map01100,path:map01502 D-Amino acid metabolism,Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance 42.0 355.0 192.0 10.0 0.597643097643098 F 58.0 533.0 11.0 0.80976430976431 COG1181 D-alanine-D-alanine_ligase_or_related_ATP-grasp_enzyme DdlA 591.0 0.0981387478849407 0.9018612521150592 0.123784268994918 0.529809523904432 0.326796896449675 0.406025254909514 0 0 0 0 K01923 0.6142857142857143 0.8575498575498576 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 126.0 568.0 567.0 2.0 0.998242530755712 F 225.0 344.0 4.0 0.956063268892794 COG0152 Phosphoribosylaminoimidazole-succinocarboxamide_synthase PurC 569.0 0.3954305799648506 0.6045694200351494 0.0077460882119055 0.729090587151763 0.3684183376818342 0.7213444989398575 0 0 0 0 K01924 0.02 0.9173789173789174 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 190.0 401.0 400.0 2.0 0.997512437810945 M 14.0 388.0 4.0 0.888059701492537 COG0773 UDP-N-acetylmuramate-alanine_ligase_MurC_and_related_ligases,_MurC/Mpl_family MurC 402.0 0.0348258706467661 0.965174129353234 0.753320549773669 0.0757655444106068 0.4145430470921379 0.6775550053630622 1 1 1 1 K01925 0.0228571428571428 0.9287749287749288 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] path:map00470,path:map00550,path:map01100 D-Amino acid metabolism,Peptidoglycan biosynthesis,Metabolic pathways 133.0 339.0 330.0 3.0 0.960339943342776 M 15.0 338.0 3.0 0.977337110481586 COG0771 UDP-N-acetylmuramoylalanine-D-glutamate_ligase MurD 353.0 0.0424929178470254 0.9575070821529744 0.0464880264016122 0.0115065964244475 0.0289973114130298 0.0349814299771647 0 0 0 0 K01926 0.0 0.3532763532763532 rex; redox-sensing transcriptional repressor 138.0 143.0 0.0 1.0 1.0 K 0.0 143.0 1.0 1.0 COG2344 NADH/NAD_ratio-sensing_transcriptional_regulator_Rex Rex 143.0 0.0 1.0 0.0709444658405193 0.0023487156943277 0.0366465907674235 0.0685957501461916 0 0 0 0 K01928 0.02 0.9515669515669516 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13] path:map00300,path:map00550,path:map01100 Lysine biosynthesis,Peptidoglycan biosynthesis,Metabolic pathways 138.0 416.0 415.0 2.0 0.997601918465228 M 7.0 409.0 5.0 0.928057553956834 COG0769 UDP-N-acetylmuramyl_tripeptide_synthase MurE 416.0 0.016826923076923 0.9831730769230768 0.18210295482069 0.560895788537523 0.3714993716791065 0.378792833716833 0 0 0 0 K01929 0.0114285714285714 0.9373219373219374 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] path:map00300,path:map00550,path:map01100,path:map01502 Lysine biosynthesis,Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance 75.0 378.0 369.0 4.0 0.954545454545455 M 4.0 392.0 7.0 0.896464646464647 COG0770 UDP-N-acetylmuramyl_pentapeptide_synthase MurF 396.0 0.0101010101010101 0.98989898989899 0.0005392593345747 0.1273903315378 0.0639647954361873 0.1268510722032253 0 0 0 0 K01932 0.0542857142857142 0.0826210826210826 capB, pgsB; gamma-polyglutamate synthase [EC:6.3.2.-] 161.0 40.0 35.0 4.0 0.769230769230769 M 21.0 31.0 5.0 0.403846153846154 arCOG06251 52.0 0.4038461538461538 0.5961538461538461 0.441410982874284 0.468969315409766 0.455190149142025 0.027558332535482 0 0 0 0 K01933 0.6371428571428571 0.8518518518518519 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 188.0 525.0 509.0 2.0 0.970425138632163 F 239.0 302.0 4.0 0.942698706099815 COG0150 Phosphoribosylaminoimidazole_(AIR)_synthetase PurM 541.0 0.4417744916820702 0.5582255083179297 0.0389363088087323 0.921815770345163 0.4803760395769477 0.8828794615364307 0 0 0 0 K01934 0.4085714285714286 0.7236467236467237 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] path:map00670,path:map01100 One carbon pool by folate,Metabolic pathways 20.0 422.0 420.0 2.0 0.995283018867924 H 154.0 267.0 2.0 0.995283018867924 COG0212 5-formyltetrahydrofolate_cyclo-ligase FAU1 421.0 0.3657957244655582 0.6342042755344418 0.0327985023691663 0.0875881682323363 0.0601933353007513 0.0547896658631699 0 0 0 0 K01935 0.0971428571428571 0.4586894586894587 bioD; dethiobiotin synthetase [EC:6.3.3.3] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 64.0 204.0 202.0 4.0 0.976076555023923 H 34.0 175.0 3.0 0.976076555023923 COG0132 Dethiobiotin_synthetase BioD 209.0 0.1626794258373205 0.8373205741626795 0.0034249048544191 0.0515447987195607 0.0274848517869898 0.0481198938651416 0 0 0 0 K01937 0.86 0.9373219373219374 pyrG, CTPS; CTP synthase [EC:6.3.4.2] path:map00240,path:map01100,path:map01232,path:map01240 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism,Biosynthesis of cofactors 318.0 658.0 637.0 3.0 0.952243125904486 F 347.0 344.0 3.0 0.952243125904486 COG0504 CTP_synthase_(UTP-ammonia_lyase) PyrG 691.0 0.5021707670043415 0.4978292329956584 0.907048847522722 0.911466264283926 0.909257555903324 0.0044174167612039 1 1 1 1 K01938 0.1714285714285714 0.4444444444444444 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] path:map00670,path:map00720,path:map01100,path:map01120,path:map01200,path:map01240 One carbon pool by folate,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of cofactors 485.0 162.0 91.0 2.0 0.695278969957082 F 63.0 170.0 1.0 1.0 COG2759 Formyltetrahydrofolate_synthetase MIS1 233.0 0.2703862660944206 0.7296137339055794 0.99056166021462 0.970319380372331 0.9804405202934756 0.0202422798422889 1 1 1 1 K01939 0.6742857142857143 0.8689458689458689 purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4] path:map00230,path:map00250,path:map01100,path:map01232,path:map01240 Purine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Nucleotide metabolism,Biosynthesis of cofactors 192.0 569.0 567.0 3.0 0.994755244755245 F 240.0 332.0 4.0 0.991258741258741 COG0104 Adenylosuccinate_synthase PurA 572.0 0.4195804195804196 0.5804195804195804 0.156922588425957 0.725903501363427 0.4414130448946919 0.56898091293747 0 0 0 0 K01940 0.5485714285714286 0.7692307692307693 argG, ASS1; argininosuccinate synthase [EC:6.3.4.5] path:map00220,path:map00250,path:map01100,path:map01110,path:map01230,path:map05418 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Fluid shear stress and atherosclerosis 314.0 440.0 415.0 3.0 0.918580375782881 E 202.0 277.0 1.0 1.0 COG0137 Argininosuccinate_synthase ArgG 479.0 0.4217118997912317 0.5782881002087683 0.735719652407087 0.901400717153418 0.8185601847802525 0.1656810647463309 0 1 0 1 K01941 0.0 0.0 E6.3.4.6; urea carboxylase [EC:6.3.4.6] path:map00220,path:map00791,path:map01100 Arginine biosynthesis,Atrazine degradation,Metabolic pathways 17.0 1.0 5.0 0.320754716981132 I 0.0 0.0 6.0 0.622641509433962 COG0439 Biotin_carboxylase AccC 0.0 0 0 0 0 K01942 0.0028571428571428 0.0 HLCS; biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15] path:map00780,path:map01100 Biotin metabolism,Metabolic pathways 295.0 1.0 0.0 1.0 1.0 H 1.0 0.0 1.0 1.0 COG0340 Biotin-(acetyl-CoA_carboxylase)_ligase BirA2 1.0 1.0 0.0 0 0 0 0 K01945 0.6628571428571428 0.8746438746438746 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 155.0 633.0 0.0 1.0 1.0 F 260.0 372.0 3.0 0.933649289099526 COG0151 Phosphoribosylamine-glycine_ligase PurD 632.0 0.4113924050632911 0.5886075949367089 0.0061952467850949 0.0320840364896993 0.0191396416373971 0.0258887897046043 0 0 0 0 K01947 0.0 0.0541310541310541 birA-coaX; biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33] path:map00770,path:map00780,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 137.0 11.0 4.0 3.0 0.578947368421053 F 0.0 19.0 2.0 0.736842105263158 COG1521 Pantothenate_kinase_type_III CoaX 19.0 0.0 1.0 0.0253771746039238 0.0447779922737291 0.0350775834388264 0.0194008176698053 0 0 0 0 K01948 0.0057142857142857 0.0028490028490028 CPS1; carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16] path:map00220,path:map00250,path:map00910,path:map01100,path:map01120,path:map01200,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 311.0 2.0 1.0 2.0 0.666666666666667 F 2.0 1.0 2.0 0.666666666666667 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K01949 0.0 0.0541310541310541 gmaS; glutamate---methylamine ligase [EC:6.3.4.12] 426.0 21.0 0.0 1.0 1.0 E 0.0 21.0 1.0 1.0 COG0174 Glutamine_synthetase GlnA 21.0 0.0 1.0 0.0224606465817885 0.0686738816045394 0.0455672640931639 0.0462132350227509 0 0 0 0 K01950 0.1057142857142857 0.5669515669515669 E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 315.0 238.0 228.0 4.0 0.948207171314741 H 42.0 209.0 3.0 0.936254980079681 COG0171 NH3-dependent_NAD+_synthetase NadE 251.0 0.1673306772908366 0.8326693227091634 0.0860124220747087 0.432787005079012 0.2593997135768603 0.3467745830043033 0 0 0 0 K01951 0.0 0.0 guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] path:map00230,path:map00983,path:map01100,path:map01232 Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism 990.0 989.0 2.0 0.99899091826438 F 0.0 0.0 4.0 0.642785065590313 COG0518 GMP_synthase,_glutamine_amidotransferase_domain GuaA1 0.0 0 0 0 0 K01952 0.0 0.0 PFAS, purL; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 1268.0 1264.0 3.0 0.995290423861852 F 0.0 0.0 6.0 0.423861852433281 COG0046 Phosphoribosylformylglycinamidine_(FGAM)_synthase,_synthetase_domain PurL1 0.0 0 0 0 0 K01953 0.0 0.0 asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] path:map00250,path:map01100,path:map01110,path:map01230 Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 765.0 722.0 5.0 0.940959409594096 E 0.0 0.0 7.0 0.961963190184049 COG0367 Asparagine_synthetase_B_(glutamine-hydrolyzing) AsnB 0.0 0 0 0 0 K01954 0.0028571428571428 0.0 K01954; carbamoyl-phosphate synthase [EC:6.3.5.5] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 465.0 1.0 0.0 1.0 1.0 EF 1.0 0.0 1.0 1.0 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 1.0 1.0 0.0 0 0 0 0 K01955 0.64 0.8376068376068376 carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 87.0 417.0 297.0 8.0 0.585674157303371 F 293.0 408.0 11.0 0.838483146067416 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 701.0 0.4179743223965763 0.5820256776034237 0.527023221332145 0.422028260752373 0.474525741042259 0.1049949605797719 0 1 0 1 K01956 0.6114285714285714 0.8005698005698005 carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 215.0 365.0 253.0 3.0 0.70873786407767 F 222.0 293.0 1.0 1.0 COG0505 Carbamoylphosphate_synthase_small_subunit CarA 515.0 0.4310679611650485 0.5689320388349515 0.305491922594405 0.0056374828862938 0.1555647027403494 0.2998544397081112 0 0 0 0 K01958 0.0028571428571428 0.2421652421652421 PC, pyc; pyruvate carboxylase [EC:6.4.1.1] path:map00020,path:map00620,path:map00720,path:map01100,path:map01120,path:map01200,path:map01230 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 1016.0 87.0 86.0 2.0 0.988636363636364 C 1.0 87.0 2.0 0.988636363636364 COG1038 Pyruvate_carboxylase PycA 88.0 0.0113636363636363 0.9886363636363636 0.0142708814025259 0.104732899423895 0.0595018904132104 0.0904620180213691 0 0 0 0 K01959 0.1971428571428571 0.0968660968660968 pycA; pyruvate carboxylase subunit A [EC:6.4.1.1] path:map00020,path:map00620,path:map00720,path:map01100,path:map01120,path:map01200,path:map01230 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 435.0 103.0 101.0 3.0 0.971698113207547 I 69.0 36.0 3.0 0.915094339622642 COG0439 Biotin_carboxylase AccC 105.0 0.6571428571428571 0.3428571428571428 0.578236225807771 0.960738521056088 0.7694873734319295 0.382502295248317 0 1 0 1 K01960 0.2257142857142857 0.2478632478632478 pycB; pyruvate carboxylase subunit B [EC:6.4.1.1] path:map00020,path:map00620,path:map00720,path:map01100,path:map01120,path:map01200,path:map01230 Citrate cycle (TCA cycle),Pyruvate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 67.0 131.0 98.0 3.0 0.696808510638298 C 89.0 98.0 3.0 0.462765957446809 COG5016 Pyruvate/oxaloacetate_carboxyltransferase OadA1 187.0 0.4759358288770053 0.5240641711229946 0.882669502000954 0.896453127625155 0.8895613148130546 0.0137836256242011 1 1 1 1 K01961 0.06 0.7008547008547008 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] path:map00061,path:map00620,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Pyruvate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 356.0 339.0 333.0 2.0 0.982608695652174 I 27.0 318.0 2.0 0.973913043478261 COG0439 Biotin_carboxylase AccC 345.0 0.0782608695652174 0.9217391304347826 0.0008835276985082 0.159894416342327 0.0803889720204176 0.1590108886438188 0 0 0 0 K01962 0.0057142857142857 0.6752136752136753 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] path:map00061,path:map00620,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Pyruvate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 224.0 267.0 262.0 3.0 0.970909090909091 I 2.0 273.0 4.0 0.781818181818182 COG0825 Acetyl-CoA_carboxylase_alpha_subunit AccA 275.0 0.0072727272727272 0.9927272727272728 0.001834777739985 0.21141242015178 0.1066235989458825 0.209577642411795 0 0 0 0 K01963 0.0057142857142857 0.6837606837606838 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] path:map00061,path:map00620,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Pyruvate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 203.0 276.0 273.0 3.0 0.978723404255319 I 2.0 280.0 4.0 0.882978723404255 COG0777 Acetyl-CoA_carboxylase_beta_subunit AccD 282.0 0.0070921985815602 0.9929078014184396 0.0462524070975758 0.103231871399056 0.0747421392483159 0.0569794643014802 0 0 0 0 K01964 0.0428571428571428 0.0 K01964; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 475.0 15.0 0.0 1.0 1.0 I 15.0 0.0 1.0 1.0 COG0439 Biotin_carboxylase AccC 15.0 1.0 0.0 0.0002440433213809 0.0016179571607014 0.0009310002410411 0.0013739138393205 0 0 0 0 K01965 0.0114285714285714 0.2108262108262108 PCCA, pccA; propionyl-CoA carboxylase alpha chain [EC:6.4.1.3] path:map00280,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 400.0 93.0 92.0 2.0 0.98936170212766 I 4.0 82.0 3.0 0.797872340425532 COG4770 Acetyl/propionyl-CoA_carboxylase,_alpha_subunit PccA 86.0 0.0465116279069767 0.9534883720930232 0.0028125824770466 0.0471444535225282 0.0249785179997873 0.0443318710454816 0 0 0 0 K01966 0.0971428571428571 0.3675213675213675 PCCB, pccB; propionyl-CoA carboxylase beta chain [EC:6.4.1.3 2.1.3.15] path:map00280,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 481.0 201.0 0.0 1.0 1.0 I 42.0 159.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 201.0 0.208955223880597 0.7910447761194029 0.0955602618862273 0.867039610526102 0.4812999362061646 0.7714793486398748 0 0 0 0 K01968 0.0457142857142857 0.2079772079772079 E6.4.1.4A; 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 153.0 116.0 113.0 2.0 0.974789915966386 I 26.0 92.0 3.0 0.848739495798319 COG4770 Acetyl/propionyl-CoA_carboxylase,_alpha_subunit PccA 118.0 0.2203389830508474 0.7796610169491526 0.0026613421931651 0.173067614791188 0.0878644784921765 0.1704062725980229 0 0 0 0 K01969 0.0485714285714285 0.2108262108262108 E6.4.1.4B; 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 510.0 98.0 0.0 1.0 1.0 I 18.0 80.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 98.0 0.1836734693877551 0.8163265306122449 0.0012724728346192 0.135700153090425 0.0684863129625221 0.1344276802558058 0 0 0 0 K01971 0.0 0.0 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1] path:map03450 Non-homologous end-joining 187.0 177.0 4.0 0.921182266009852 L 0.0 0.0 5.0 0.724137931034483 COG1793 ATP-dependent_DNA_ligase CDC9 0.0 0 0 0 0 K01972 0.1857142857142857 0.9401709401709402 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] path:map03030,path:map03410,path:map03420,path:map03430 DNA replication,Base excision repair,Nucleotide excision repair,Mismatch repair 379.0 432.0 431.0 3.0 0.995391705069124 L 72.0 362.0 1.0 1.0 COG0272 NAD-dependent_DNA_ligase Lig 434.0 0.1658986175115207 0.8341013824884793 0.0971318334741048 0.638937672605348 0.3680347530397264 0.5418058391312431 0 0 0 0 K01974 0.5228571428571429 0.0883190883190883 RTCA, rtcA; RNA 3'-terminal phosphate cyclase (ATP) [EC:6.5.1.4] 221.0 176.0 135.0 4.0 0.792792792792793 J 189.0 33.0 1.0 1.0 COG0430 RNA_3'-terminal_phosphate_cyclase RCL1 222.0 0.8513513513513513 0.1486486486486486 0.902577402151571 0.906982401808028 0.9047799019797996 0.004404999656457 1 1 1 1 K01975 0.82 0.5213675213675214 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58] 16.0 483.0 0.0 1.0 1.0 J 297.0 186.0 1.0 1.0 COG1514 RNA_2',3'-cyclic_phosphodiesterase_(2'-5'_RNA_ligase) ThpR 483.0 0.6149068322981367 0.3850931677018633 0.847859231441164 0.860970889532144 0.854415060486654 0.0131116580909799 1 1 1 1 K01989 0.0028571428571428 0.2678062678062678 K01989; putative tryptophan/tyrosine transport system substrate-binding protein 93.0 154.0 151.0 2.0 0.980891719745223 S 1.0 156.0 3.0 0.961783439490446 COG2984 ABC-type_uncharacterized_transport_system,_periplasmic_component 157.0 0.0063694267515923 0.9936305732484076 0.0068889042204221 0.129129089714976 0.068008996967699 0.1222401854945539 0 0 0 0 K01990 0.8942857142857142 0.9515669515669516 ABC-2.A; ABC-2 type transport system ATP-binding protein 6.0 3235.0 2569.0 15.0 0.747631153223943 V 1861.0 2355.0 20.0 0.897619597873816 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 4216.0 0.4414136622390892 0.5585863377609108 0 0 0 0 K01991 0.0 0.4501424501424501 wza, gfcE; polysaccharide biosynthesis/export protein path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 8.0 304.0 294.0 6.0 0.944099378881988 M 0.0 313.0 8.0 0.934782608695652 COG1596 Periplasmic_protein_Wza_involved_in_polysaccharide_export,_contains_SLBB_domain_of_the_beta-grasp_fold Wza 313.0 0.0 1.0 0.127256787549809 0.0690441236387948 0.0981504555943018 0.0582126639110141 0 0 0 0 K01992 0.0 0.0 ABC-2.P; ABC-2 type transport system permease protein 1735.0 759.0 14.0 0.508201523140012 V 0.0 0.0 74.0 0.504178272980501 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 0.0 0 0 0 0 K01993 0.0 0.3475783475783476 ABC-2.TX; HlyD family secretion protein 127.0 113.0 46.0 4.0 0.60752688172043 M 0.0 185.0 2.0 0.639784946236559 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 185.0 0.0 1.0 0.0060821367500332 0.0178753360358341 0.0119787363929336 0.0117931992858009 0 0 0 0 K01994 0.0 0.0256410256410256 gerE; LuxR family transcriptional regulator, transcriptional regulator of spore coat protein 65.0 9.0 0.0 1.0 1.0 K 0.0 9.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 9.0 0.0 1.0 0.0064815715731552 0.0177878500225325 0.0121347107978438 0.0113062784493773 0 0 0 0 K01995 0.34 0.5071225071225072 livG; branched-chain amino acid transport system ATP-binding protein path:map02010,path:map02024 ABC transporters,Quorum sensing 113.0 868.0 818.0 6.0 0.937365010799136 E 287.0 639.0 8.0 0.954643628509719 COG0411 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivG LivG 926.0 0.3099352051835853 0.6900647948164147 0.685243120894108 0.930829180093761 0.8080361504939345 0.245586059199653 0 1 0 1 K01996 0.3457142857142857 0.5128205128205128 livF; branched-chain amino acid transport system ATP-binding protein path:map02010,path:map02024 ABC transporters,Quorum sensing 128.0 889.0 877.0 4.0 0.984496124031008 E 288.0 615.0 4.0 0.993355481727575 COG0410 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivF LivF 903.0 0.3189368770764119 0.6810631229235881 0.028882176471111 0.328720490511997 0.178801333491554 0.2998383140408859 0 0 0 0 K01997 0.3028571428571429 0.4957264957264957 livH; branched-chain amino acid transport system permease protein path:map02010,path:map02024 ABC transporters,Quorum sensing 100.0 783.0 700.0 3.0 0.852013057671382 E 274.0 645.0 3.0 0.96626768226333 COG0559 Branched-chain_amino_acid_ABC-type_transport_system,_permease_component LivH 919.0 0.2981501632208923 0.7018498367791077 0.178397234809049 0.871113613342848 0.5247554240759484 0.692716378533799 0 0 0 0 K01998 0.3285714285714285 0.5185185185185185 livM; branched-chain amino acid transport system permease protein path:map02010,path:map02024 ABC transporters,Quorum sensing 70.0 794.0 699.0 6.0 0.808553971486762 E 295.0 674.0 7.0 0.854378818737271 COG4177 ABC-type_branched-chain_amino_acid_transport_system,_permease_component LivM 969.0 0.304437564499484 0.695562435500516 0.541490538966463 0.907604738022576 0.7245476384945195 0.366114199056113 0 1 0 1 K01999 0.0 0.0 livK; branched-chain amino acid transport system substrate-binding protein path:map02010,path:map02024 ABC transporters,Quorum sensing 1199.0 1174.0 11.0 0.964601769911504 E 0.0 0.0 11.0 0.958165728077232 COG0683 ABC-type_branched-chain_amino_acid_transport_system,_periplasmic_component LivK 0.0 0 0 0 0 K02000 0.0457142857142857 0.2507122507122507 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] path:map02010 ABC transporters 268.0 115.0 102.0 4.0 0.793103448275862 E 16.0 129.0 9.0 0.703448275862069 COG4175 ABC-type_proline/glycine_betaine_transport_system,_ATPase_component ProV 145.0 0.1103448275862069 0.8896551724137931 0.0154999740151748 0.103292094536843 0.0593960342760089 0.0877921205216682 0 0 0 0 K02001 0.0428571428571428 0.2193732193732193 proW; glycine betaine/proline transport system permease protein path:map02010 ABC transporters 205.0 77.0 25.0 3.0 0.583333333333333 P 15.0 117.0 3.0 0.856060606060606 COG4176 ABC-type_proline/glycine_betaine_transport_system,_permease_component ProW 132.0 0.1136363636363636 0.8863636363636364 0.016395014235663 0.274132009170177 0.1452635117029199 0.257736994934514 0 0 0 0 K02002 0.0428571428571428 0.2336182336182336 proX; glycine betaine/proline transport system substrate-binding protein path:map02010 ABC transporters 113.0 169.0 147.0 4.0 0.875647668393782 E 21.0 156.0 4.0 0.854922279792746 COG2113 ABC-type_proline/glycine_betaine_transport_system,_periplasmic_component ProX 177.0 0.1186440677966101 0.8813559322033898 0.0055091862743824 0.0178939952150444 0.0117015907447134 0.0123848089406619 0 0 0 0 K02003 0.8228571428571428 0.9316239316239316 ABC.CD.A; putative ABC transport system ATP-binding protein 59.0 1394.0 1014.0 8.0 0.697 V 719.0 1278.0 9.0 0.936 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 1997.0 0.3600400600901352 0.6399599399098648 0 0 0 0 K02004 0.0 0.0 ABC.CD.P; putative ABC transport system permease protein 1827.0 1673.0 12.0 0.815989280928986 V 0.0 0.0 14.0 0.86153161175423 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 0.0 0 0 0 0 K02005 0.0028571428571428 0.6524216524216524 ABC.CD.TX; HlyD family secretion protein 21.0 502.0 492.0 5.0 0.970986460348162 M 1.0 512.0 3.0 0.980657640232108 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 513.0 0.0019493177387914 0.9980506822612084 0.195087554399319 0.244541579569736 0.2198145669845275 0.049454025170417 0 0 0 0 K02006 0.38 0.2991452991452991 cbiO; cobalt/nickel transport system ATP-binding protein path:map02010 ABC transporters 108.0 294.0 260.0 4.0 0.857142857142857 P 209.0 134.0 7.0 0.938775510204082 COG1122 Energy-coupling_factor_transporter_ATP-binding_protein_EcfA2 EcfA2 343.0 0.60932944606414 0.39067055393586 0.843845409524562 0.963112125232975 0.9034787673787684 0.1192667157084129 1 1 1 1 K02007 0.3485714285714286 0.3133903133903133 cbiM; cobalt/nickel transport system permease protein path:map02010 ABC transporters 119.0 356.0 355.0 2.0 0.997198879551821 P 217.0 140.0 3.0 0.966386554621849 COG0310 ABC-type_Co2+_transport_system,_permease_component CbiM 357.0 0.6078431372549019 0.392156862745098 0.788089163408373 0.907955036371449 0.8480220998899111 0.119865872963076 1 1 1 1 K02008 0.3 0.3076923076923077 cbiQ; cobalt/nickel transport system permease protein path:map02010 ABC transporters 71.0 300.0 295.0 2.0 0.983606557377049 P 169.0 137.0 5.0 0.93485342019544 COG0619 ECF-type_transporter_transmembrane_protein_EcfT EcfT 306.0 0.5522875816993464 0.4477124183006536 0.688465754310721 0.863209666973919 0.77583771064232 0.174743912663198 0 1 0 1 K02009 0.2628571428571428 0.2079772079772079 cbiN; cobalt/nickel transport protein path:map02010 ABC transporters 22.0 213.0 211.0 4.0 0.981566820276498 P 128.0 91.0 7.0 0.452054794520548 COG0310 ABC-type_Co2+_transport_system,_permease_component CbiM 219.0 0.5844748858447488 0.4155251141552511 0.514257271816698 0.140089187587835 0.3271732297022665 0.374168084228863 0 1 0 1 K02010 0.2257142857142857 0.5128205128205128 afuC, fbpC; iron(III) transport system ATP-binding protein [EC:7.2.2.7] path:map02010 ABC transporters 148.0 211.0 2.0 3.0 0.495305164319249 P 123.0 301.0 6.0 0.734741784037559 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 424.0 0.2900943396226415 0.7099056603773585 0.0424550157351873 0.425957652408035 0.2342063340716111 0.3835026366728477 0 0 0 0 K02011 0.1342857142857142 0.4102564102564102 afuB, fbpB; iron(III) transport system permease protein path:map02010 ABC transporters 298.0 268.0 254.0 4.0 0.940350877192982 P 53.0 232.0 2.0 0.992982456140351 COG1178 ABC-type_Fe3+_transport_system,_permease_component FbpB 285.0 0.1859649122807017 0.8140350877192982 0.34935231371323 0.860161309056141 0.6047568113846855 0.5108089953429109 0 0 0 0 K02012 0.1257142857142857 0.4159544159544159 afuA, fbpA; iron(III) transport system substrate-binding protein path:map02010 ABC transporters 87.0 282.0 280.0 3.0 0.986013986013986 P 48.0 238.0 3.0 0.982517482517482 COG1840 ABC-type_Fe3+_transport_system,_periplasmic_component AfuA 286.0 0.1678321678321678 0.8321678321678322 0.385729229266779 0.902321809410444 0.6440255193386115 0.516592580143665 0 0 0 0 K02013 0.4885714285714285 0.7094017094017094 ABC.FEV.A; iron complex transport system ATP-binding protein [EC:7.2.2.-] 52.0 420.0 109.0 9.0 0.411361410381978 HP 387.0 633.0 13.0 0.798237022526934 COG1120 ABC-type_cobalamin/Fe3+-siderophores_transport_system,_ATPase_component FepC 1020.0 0.3794117647058823 0.6205882352941177 0.707105063462459 0.699931598356268 0.7035183309093636 0.0071734651061911 0 1 0 1 K02014 0.0 0.0 TC.FEV.OM; iron complex outermembrane recepter protein 739.0 542.0 12.0 0.733862959285005 P 0.0 0.0 16.0 0.435948361469712 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 0.0 0 0 0 0 K02015 0.48 0.6809116809116809 ABC.FEV.P; iron complex transport system permease protein 121.0 1017.0 983.0 5.0 0.963981042654028 P 393.0 662.0 6.0 0.901421800947867 COG0609 ABC-type_Fe3+-siderophore_transport_system,_permease_component FepD 1055.0 0.3725118483412322 0.6274881516587678 0.802338297747256 0.719448439013301 0.7608933683802785 0.0828898587339549 1 1 1 1 K02016 0.0 0.0 ABC.FEV.S; iron complex transport system substrate-binding protein 1350.0 1344.0 9.0 0.985401459854015 P 0.0 0.0 17.0 0.790194664744052 COG0614 ABC-type_Fe3+-hydroxamate_transport_system,_periplasmic_component FepB 0.0 0 0 0 0 K02017 0.2571428571428571 0.5441595441595442 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5] path:map02010 ABC transporters 73.0 187.0 21.0 6.0 0.472222222222222 P 133.0 261.0 9.0 0.373737373737374 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 394.0 0.3375634517766497 0.6624365482233503 0.767268090827534 0.848433154392085 0.8078506226098094 0.081165063564551 1 1 1 1 K02018 0.1628571428571428 0.5327635327635327 modB; molybdate transport system permease protein path:map02010 ABC transporters 146.0 296.0 286.0 4.0 0.93968253968254 P 74.0 240.0 5.0 0.6 COG4149 ABC-type_molybdate_transport_system,_permease_component_ModB ModB 314.0 0.2356687898089172 0.7643312101910829 0.140640229834746 0.343199557813225 0.2419198938239855 0.2025593279784789 0 0 0 0 K02019 0.2885714285714286 0.225071225071225 modE; molybdate transport system regulatory protein 58.0 95.0 42.0 6.0 0.402542372881356 H 108.0 104.0 4.0 0.843220338983051 COG2005 DNA-binding_transcriptional_regulator_ModE_(molybdenum-dependent) ModE 212.0 0.5094339622641509 0.490566037735849 0.205950204941763 0.845924111741428 0.5259371583415955 0.639973906799665 0 0 0 0 K02020 0.1428571428571428 0.5356125356125356 modA; molybdate transport system substrate-binding protein path:map02010 ABC transporters 64.0 308.0 306.0 4.0 0.987179487179487 P 69.0 243.0 4.0 0.987179487179487 COG0725 ABC-type_molybdate_transport_system,_periplasmic_Mo-binding_protein_ModA ModA 312.0 0.2211538461538461 0.7788461538461539 0.0420690966369331 0.318412740058993 0.180240918347963 0.2763436434220599 0 0 0 0 K02021 0.0028571428571428 0.2621082621082621 ABC.MR; putative ABC transport system ATP-binding protein 301.0 101.0 96.0 3.0 0.918181818181818 V 1.0 109.0 5.0 0.790909090909091 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 110.0 0.009090909090909 0.990909090909091 0.62326702974162 0.142724318213129 0.3829956739773745 0.4805427115284909 0 0 0 1 K02022 0.0028571428571428 0.1965811965811965 ABC.MR.TX; HlyD family secretion protein 83.0 111.0 95.0 6.0 0.81021897810219 M 1.0 137.0 5.0 0.839416058394161 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 138.0 0.0072463768115942 0.9927536231884058 0.0082638145874986 0.0283341843231853 0.0182989994553419 0.0200703697356867 0 0 0 0 K02024 0.0 0.0341880341880341 lamB; maltoporin 160.0 9.0 4.0 3.0 0.473684210526316 G 0.0 19.0 2.0 0.736842105263158 COG4580 Maltoporin_(phage_lambda_and_maltose_receptor) LamB 19.0 0.0 1.0 0.0162830768402151 0.0319051404927652 0.0240941086664901 0.0156220636525501 0 0 0 0 K02025 0.2285714285714285 0.4643874643874643 ABC.MS.P; multiple sugar transport system permease protein 45.0 599.0 217.0 4.0 0.590147783251232 P 201.0 814.0 7.0 0.983267716535433 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 1015.0 0.1980295566502463 0.8019704433497536 0.504286389246791 0.546914648767853 0.5256005190073221 0.0426282595210619 0 1 0 1 K02026 0.2257142857142857 0.4843304843304843 ABC.MS.P1; multiple sugar transport system permease protein 64.0 565.0 177.0 5.0 0.562189054726368 P 188.0 816.0 6.0 0.966169154228856 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 1004.0 0.1872509960159362 0.8127490039840638 0.122585874098963 0.767772739674457 0.44517930688671 0.645186865575494 0 0 0 0 K02027 0.0 0.0 ABC.MS.S; multiple sugar transport system substrate-binding protein 971.0 954.0 8.0 0.955708661417323 G 0.0 0.0 9.0 0.874015748031496 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 0.0 0 0 0 0 K02028 0.2342857142857143 0.5128205128205128 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1] 145.0 461.0 443.0 7.0 0.898635477582846 E 94.0 420.0 10.0 0.877431906614786 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 514.0 0.1828793774319066 0.8171206225680934 0.112777360899882 0.109393625842844 0.111085493371363 0.0033837350570379 0 0 0 0 K02029 0.1857142857142857 0.5441595441595442 ABC.PA.P; polar amino acid transport system permease protein 74.0 398.0 144.0 7.0 0.546703296703297 P 113.0 617.0 9.0 0.794520547945205 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 730.0 0.1547945205479452 0.8452054794520548 0.531225028550221 0.424435321806695 0.477830175178458 0.106789706743526 0 1 0 1 K02030 0.0 0.0 ABC.PA.S; polar amino acid transport system substrate-binding protein 629.0 527.0 13.0 0.660714285714286 ET 0.0 0.0 30.0 0.758909853249476 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 0.0 0 0 0 0 K02031 0.5257142857142857 0.7037037037037037 ddpD; peptide/nickel transport system ATP-binding protein path:map02024 Quorum sensing 88.0 799.0 248.0 5.0 0.497819314641745 P 666.0 923.0 5.0 0.720872274143302 COG0444 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppD 1589.0 0.4191315292636878 0.5808684707363121 0.58587453232581 0.483368661615863 0.5346215969708366 0.1025058707099469 0 1 0 1 K02032 0.5314285714285715 0.6951566951566952 ddpF; peptide/nickel transport system ATP-binding protein path:map02024 Quorum sensing 114.0 768.0 26.0 5.0 0.486692015209125 P 650.0 925.0 6.0 0.61660329531052 COG4608 ABC-type_oligopeptide_transport_system,_ATPase_component AppF 1575.0 0.4126984126984127 0.5873015873015873 0.734377148317962 0.886281770884189 0.8103294596010755 0.151904622566227 0 1 0 1 K02033 0.5228571428571429 0.6866096866096866 ABC.PE.P; peptide/nickel transport system permease protein path:map02024 Quorum sensing 94.0 1190.0 837.0 6.0 0.730509515039902 P 656.0 972.0 5.0 0.994475138121547 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 1628.0 0.4029484029484029 0.597051597051597 0 0 0 0 K02034 0.5057142857142857 0.6866096866096866 ABC.PE.P1; peptide/nickel transport system permease protein path:map02024 Quorum sensing 40.0 939.0 304.0 7.0 0.573610262675626 P 626.0 992.0 7.0 0.953573610262676 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 1618.0 0.3868974042027194 0.6131025957972805 0 0 0 0 K02035 0.5228571428571429 0.8148148148148148 ABC.PE.S; peptide/nickel transport system substrate-binding protein path:map02024 Quorum sensing 5.0 1931.0 1867.0 7.0 0.956888007928642 E 736.0 1215.0 18.0 0.870206489675516 COG0747 ABC-type_transport_system,_periplasmic_component DdpA 1951.0 0.3772424397744746 0.6227575602255254 0 0 0 0 K02036 0.4885714285714285 0.7350427350427351 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] path:map02010 ABC transporters 188.0 577.0 0.0 1.0 1.0 P 226.0 351.0 2.0 0.998266897746967 COG1117 ABC-type_phosphate_transport_system,_ATPase_component PstB 577.0 0.3916811091854419 0.608318890814558 0.771982672368827 0.955595467911648 0.8637890701402375 0.1836127955428209 1 1 1 1 K02037 0.48 0.7207977207977208 pstC; phosphate transport system permease protein path:map02010 ABC transporters 169.0 558.0 553.0 2.0 0.991119005328597 P 241.0 322.0 4.0 0.893428063943162 COG0573 ABC-type_phosphate_transport_system,_permease_component PstC 563.0 0.4280639431616341 0.5719360568383659 0.03926349944 0.491573869916206 0.265418684678103 0.452310370476206 0 0 0 0 K02038 0.4857142857142857 0.7350427350427351 pstA; phosphate transport system permease protein path:map02010 ABC transporters 128.0 585.0 583.0 4.0 0.99320882852292 P 243.0 346.0 6.0 0.920203735144312 COG0581 ABC-type_phosphate_transport_system,_permease_component PstA 589.0 0.4125636672325976 0.5874363327674024 0.456863954782126 0.916404181748203 0.6866340682651645 0.459540226966077 0 0 0 0 K02039 0.4742857142857143 0.7207977207977208 phoU; phosphate transport system protein 49.0 516.0 480.0 2.0 0.934782608695652 P 234.0 318.0 7.0 0.936594202898551 COG0704 Phosphate_uptake_regulator_PhoU PhoU 552.0 0.4239130434782608 0.5760869565217391 0.002429226653347 0.354033295790792 0.1782312612220695 0.351604069137445 0 0 0 0 K02040 0.5085714285714286 0.7521367521367521 pstS; phosphate transport system substrate-binding protein path:map02010,path:map02020,path:map05152 ABC transporters,Two-component system,Tuberculosis 40.0 740.0 723.0 6.0 0.959792477302205 P 274.0 495.0 7.0 0.968871595330739 COG0226 ABC-type_phosphate_transport_system,_periplasmic_component PstS 769.0 0.3563068920676203 0.6436931079323797 0.0691054685452258 0.332748513498998 0.2009269910221119 0.2636430449537721 0 0 0 0 K02041 0.1228571428571428 0.2364672364672364 phnC; phosphonate transport system ATP-binding protein [EC:7.3.2.2] path:map02010 ABC transporters 183.0 161.0 153.0 3.0 0.947058823529412 P 55.0 115.0 3.0 0.988235294117647 COG3638 ABC-type_phosphate/phosphonate_transport_system,_ATPase_component PhnC 170.0 0.3235294117647059 0.6764705882352942 0.0108707625646643 0.0524809854255356 0.0316758739950999 0.0416102228608713 0 0 0 0 K02042 0.14 0.2307692307692307 phnE; phosphonate transport system permease protein path:map02010 ABC transporters 167.0 224.0 211.0 2.0 0.945147679324894 P 75.0 162.0 2.0 0.9957805907173 COG3639 ABC-type_phosphate/phosphonate_transport_system,_permease_component PhnE 237.0 0.3164556962025316 0.6835443037974683 0.022382893633435 0.0669731032880128 0.0446779984607239 0.0445902096545778 0 0 0 0 K02043 0.0 0.0683760683760683 phnF; GntR family transcriptional regulator, phosphonate transport system regulatory protein 212.0 25.0 0.0 1.0 1.0 K 0.0 25.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 25.0 0.0 1.0 0.0319917702328103 0.202671815629892 0.1173317929313511 0.1706800453970817 0 0 0 0 K02044 0.1285714285714285 0.3304843304843304 phnD; phosphonate transport system substrate-binding protein path:map02010 ABC transporters 30.0 271.0 267.0 6.0 0.960992907801418 P 62.0 218.0 6.0 0.957446808510638 COG3221 ABC-type_phosphate/phosphonate_transport_system,_periplasmic_component PhnD 280.0 0.2214285714285714 0.7785714285714286 0.0503757094817354 0.0704537691555764 0.0604147393186559 0.020078059673841 0 0 0 0 K02045 0.0 0.188034188034188 cysA; sulfate/thiosulfate transport system ATP-binding protein [EC:7.3.2.3] path:map00920,path:map02010 Sulfur metabolism,ABC transporters 253.0 68.0 59.0 3.0 0.860759493670886 P 0.0 79.0 4.0 0.658227848101266 COG1118 ABC-type_sulfate/molybdate_transport_systems,_ATPase_component CysA 79.0 0.0 1.0 0.0091666518929642 0.134321479112957 0.0717440655029606 0.1251548272199928 0 0 0 0 K02046 0.0085714285714285 0.1652421652421652 cysU; sulfate/thiosulfate transport system permease protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 252.0 39.0 7.0 2.0 0.549295774647887 P 3.0 68.0 2.0 0.971830985915493 COG0555 ABC-type_sulfate_transport_system,_permease_component CysU 71.0 0.0422535211267605 0.9577464788732394 0.0913859576577988 0.0873856873600835 0.0893858225089411 0.0040002702977153 0 0 0 0 K02047 0.0 0.1396011396011396 cysW; sulfate/thiosulfate transport system permease protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 254.0 58.0 0.0 1.0 1.0 P 0.0 58.0 1.0 1.0 COG4208 ABC-type_sulfate_transport_system,_permease_component CysW 58.0 0.0 1.0 0.0073522056738069 0.125159199966043 0.0662557028199249 0.1178069942922361 0 0 0 0 K02048 0.0 0.1452991452991453 cysP; sulfate/thiosulfate transport system substrate-binding protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 297.0 77.0 0.0 1.0 1.0 P 0.0 77.0 2.0 0.883116883116883 COG1613 ABC-type_sulfate_transport_system,_periplasmic_component Sbp 77.0 0.0 1.0 0.0101024523112656 0.0908820744433194 0.0504922633772925 0.0807796221320538 0 0 0 0 K02049 0.4742857142857143 0.5754985754985755 ABC.SN.A; NitT/TauT family transport system ATP-binding protein 95.0 673.0 555.0 2.0 0.850821744627054 P 227.0 564.0 8.0 0.950695322376738 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 791.0 0.2869785082174462 0.7130214917825537 0.80827161136231 0.704053359253983 0.7561624853081466 0.1042182521083269 1 1 1 1 K02050 0.4628571428571428 0.5527065527065527 ABC.SN.P; NitT/TauT family transport system permease protein 43.0 761.0 744.0 2.0 0.978149100257069 P 236.0 537.0 4.0 0.890745501285347 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 773.0 0.3053040103492885 0.6946959896507116 0.223771610462745 0.758063945947217 0.490917778204981 0.5342923354844721 0 0 0 0 K02051 0.0 0.0 ABC.SN.S; NitT/TauT family transport system substrate-binding protein 730.0 724.0 5.0 0.98250336473755 P 0.0 0.0 6.0 0.986541049798116 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 0.0 0 0 0 0 K02052 0.1057142857142857 0.2962962962962963 ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein path:map02024 Quorum sensing 216.0 132.0 3.0 3.0 0.501901140684411 P 48.0 214.0 2.0 0.88212927756654 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 262.0 0.183206106870229 0.816793893129771 0.935181824554183 0.939661406730771 0.9374216156424772 0.004479582176588 1 1 1 1 K02053 0.1342857142857142 0.2336182336182336 ABC.SP.P; putative spermidine/putrescine transport system permease protein path:map02024 Quorum sensing 156.0 147.0 67.0 3.0 0.633620689655172 P 69.0 163.0 5.0 0.745689655172414 COG1177 ABC-type_spermidine/putrescine_transport_system,_permease_component_II PotC 232.0 0.2974137931034483 0.7025862068965517 0.705313628927151 0.515946317098876 0.6106299730130135 0.189367311828275 0 1 0 1 K02054 0.08 0.2165242165242165 ABC.SP.P1; putative spermidine/putrescine transport system permease protein path:map02024 Quorum sensing 184.0 119.0 63.0 3.0 0.668539325842697 P 29.0 149.0 4.0 0.668539325842697 COG1176 ABC-type_spermidine/putrescine_transport_system,_permease_component_I PotB 178.0 0.1629213483146067 0.8370786516853933 0.935802278251536 0.939747812062998 0.937775045157267 0.003945533811462 1 1 1 1 K02055 0.0628571428571428 0.2792022792022792 ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein path:map02024 Quorum sensing 23.0 148.0 80.0 3.0 0.614107883817427 E 34.0 206.0 3.0 0.663900414937759 COG0687 Spermidine/putrescine-binding_periplasmic_protein PotD 240.0 0.1416666666666666 0.8583333333333333 0.0988152770621842 0.14674676846329 0.122781022762737 0.0479314914011057 0 0 0 0 K02056 0.2342857142857143 0.4245014245014245 ABC.SS.A; simple sugar transport system ATP-binding protein [EC:7.5.2.-] 258.0 250.0 111.0 5.0 0.470809792843691 S 134.0 397.0 3.0 0.677966101694915 COG3845 ABC-type_guanosine_uptake_system_NupNOPQ,_ATPase_component_NupO NupO 531.0 0.2523540489642185 0.7476459510357816 0.533353786476946 0.873491630147126 0.703422708312036 0.3401378436701801 0 1 0 1 K02057 0.2285714285714285 0.4615384615384615 ABC.SS.P; simple sugar transport system permease protein 50.0 521.0 341.0 8.0 0.564463705308776 S 237.0 683.0 11.0 0.372697724810401 COG1079 ABC-type_guanosine_uptake_system_NupNOPQ,_permease_subunit_NupQ NupQ 920.0 0.2576086956521739 0.7423913043478261 0.263628223490825 0.385470595040175 0.3245494092655 0.12184237154935 0 0 0 0 K02058 0.1142857142857142 0.3133903133903133 ABC.SS.S; simple sugar transport system substrate-binding protein 45.0 126.0 33.0 4.0 0.520661157024793 G 44.0 198.0 3.0 0.479338842975207 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 242.0 0.1818181818181818 0.8181818181818182 0.400245915860244 0.634197724953235 0.5172218204067395 0.233951809092991 0 0 0 0 K02062 0.2114285714285714 0.0883190883190883 thiQ; thiamine transport system ATP-binding protein [EC:7.6.2.15] path:map02010 ABC transporters 245.0 75.0 53.0 4.0 0.630252100840336 E 88.0 31.0 3.0 0.747899159663866 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 119.0 0.7394957983193278 0.2605042016806723 0.118479083246464 0.739480503184857 0.4289797932156605 0.6210014199383931 0 0 0 0 K02063 0.2542857142857143 0.1225071225071225 thiP; thiamine transport system permease protein path:map02010 ABC transporters 370.0 139.0 0.0 1.0 1.0 P 95.0 44.0 1.0 1.0 COG1178 ABC-type_Fe3+_transport_system,_permease_component FbpB 139.0 0.6834532374100719 0.316546762589928 0.731720250778319 0.873003733383375 0.802361992080847 0.1412834826050559 0 1 0 1 K02064 0.2028571428571428 0.1253561253561253 thiB, tbpA; thiamine transport system substrate-binding protein path:map02010 ABC transporters 218.0 96.0 68.0 2.0 0.774193548387097 H 80.0 44.0 1.0 1.0 COG4143 ABC-type_thiamine_transport_system,_periplasmic_component_TbpA TbpA 124.0 0.6451612903225806 0.3548387096774194 0.0819708394322817 0.733140806832165 0.4075558231322233 0.6511699673998833 0 0 0 0 K02065 0.0028571428571428 0.5783475783475783 mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein path:map02010 ABC transporters 149.0 296.0 283.0 6.0 0.927899686520376 Q 1.0 318.0 8.0 0.946708463949843 COG1127 ATPase_subunit_MlaF_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaF 319.0 0.0031347962382445 0.9968652037617556 0.0011726594965748 0.0202817352541812 0.010727197375378 0.0191090757576063 0 0 0 0 K02066 0.0 0.584045584045584 mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein path:map02010 ABC transporters 141.0 357.0 340.0 5.0 0.93455497382199 Q 0.0 382.0 3.0 0.942408376963351 COG0767 Permease_subunit_MlaE_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaE 382.0 0.0 1.0 0.0551352656627001 0.0778798860622215 0.0665075758624608 0.0227446203995214 0 0 0 0 K02067 0.0 0.5698005698005698 mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein path:map02010 ABC transporters 12.0 402.0 399.0 2.0 0.992592592592593 Q 0.0 405.0 5.0 0.977777777777778 COG1463 Periplasmic_subunit_MlaD_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaD 405.0 0.0 1.0 0.0004724173793331 0.0019114744313053 0.0011919459053192 0.0014390570519722 0 0 0 0 K02068 0.12 0.1937321937321937 STAR1, fetA; UDP-glucose/iron transport system ATP-binding protein 93.0 51.0 15.0 4.0 0.408 P 54.0 71.0 12.0 0.208 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 125.0 0.432 0.568 0.0692433775413965 0.595409545266915 0.3323264614041558 0.5261661677255185 0 0 0 0 K02069 0.0942857142857142 0.2991452991452991 STAR2, fetB; UDP-glucose/iron transport system permease protein 180.0 119.0 97.0 4.0 0.782894736842105 S 35.0 117.0 3.0 0.901315789473684 COG0390 ABC-type_iron_transport_system_FetAB,_permease_component FetB 152.0 0.2302631578947368 0.7697368421052632 0.217334731860504 0.843029023601588 0.5301818777310461 0.625694291741084 0 0 0 0 K02071 0.0 0.3447293447293447 metN; D-methionine transport system ATP-binding protein path:map02010 ABC transporters 207.0 138.0 134.0 4.0 0.945205479452055 P 0.0 146.0 8.0 0.86986301369863 COG1135 ABC-type_methionine_transport_system,_ATPase_component AbcC 146.0 0.0 1.0 0.0050494104947185 0.0917941029292145 0.0484217567119665 0.0867446924344959 0 0 0 0 K02072 0.0 0.2735042735042735 metI; D-methionine transport system permease protein path:map02010 ABC transporters 187.0 128.0 122.0 3.0 0.941176470588235 P 0.0 136.0 2.0 0.897058823529412 COG2011 ABC-type_methionine_transport_system,_permease_component MetP 136.0 0.0 1.0 0.0033485625575687 0.0439066866505162 0.0236276246040424 0.0405581240929475 0 0 0 0 K02073 0.0 0.2735042735042735 metQ; D-methionine transport system substrate-binding protein path:map02010 ABC transporters 217.0 111.0 69.0 2.0 0.725490196078431 P 0.0 153.0 1.0 1.0 COG1464 ABC-type_metal_ion_transport_system,_periplasmic_component/surface_antigen NlpA 153.0 0.0 1.0 0.0034030941606469 0.467619555602121 0.2355113248813839 0.4642164614414741 0 0 0 0 K02074 0.2314285714285714 0.2079772079772079 ABC.ZM.A; zinc/manganese transport system ATP-binding protein 144.0 118.0 51.0 2.0 0.637837837837838 P 88.0 97.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 185.0 0.4756756756756757 0.5243243243243243 0.972633548242792 0.952307876715768 0.96247071247928 0.020325671527024 1 1 1 1 K02075 0.1914285714285714 0.2507122507122507 ABC.ZM.P; zinc/manganese transport system permease protein 193.0 172.0 165.0 2.0 0.960893854748603 P 72.0 107.0 2.0 0.994413407821229 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 179.0 0.4022346368715084 0.5977653631284916 0.965279513518105 0.847429785619329 0.906354649568717 0.117849727898776 1 1 1 1 K02076 0.0028571428571428 0.1054131054131054 zurR, zur; Fur family transcriptional regulator, zinc uptake regulator 92.0 41.0 40.0 2.0 0.976190476190476 P 1.0 41.0 1.0 1.0 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 42.0 0.0238095238095238 0.9761904761904762 0.0093433413561143 0.522094567504686 0.2657189544304001 0.5127512261485717 0 0 0 0 K02077 0.16 0.3076923076923077 ABC.ZM.S; zinc/manganese transport system substrate-binding protein 40.0 206.0 203.0 2.0 0.985645933014354 P 73.0 134.0 3.0 0.904306220095694 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 207.0 0.3526570048309179 0.6473429951690821 0.25271269232564 0.601550712203568 0.427131702264604 0.348838019877928 0 0 0 0 K02078 0.04 0.8945868945868946 acpP; acyl carrier protein path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 11.0 519.0 509.0 6.0 0.970093457943925 IQ 14.0 522.0 10.0 0.973929236499069 COG0236 Acyl_carrier_protein AcpP 536.0 0.0261194029850746 0.9738805970149254 0.0240158882130174 0.0619742018863386 0.042995045049678 0.0379583136733212 0 0 0 0 K02079 0.0 0.0113960113960113 agaA; N-acetylgalactosamine-6-phosphate deacetylase [EC:3.5.1.25] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 147.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG1820 N-acetylglucosamine-6-phosphate_deacetylase NagA 4.0 0.0 1.0 9.09111025242605e-11 2.29507028639868e-09 1.1929906944614702e-09 2.2041591838744197e-09 0 0 0 0 K02080 0.0 0.0199430199430199 agaI; putative deaminase/isomerase [EC:3.5.99.-] 235.0 7.0 0.0 1.0 1.0 G 0.0 7.0 1.0 1.0 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate_isomerase/deaminase NagB 7.0 0.0 1.0 0.079967974157085 0.15134245381452 0.1156552139858025 0.071374479657435 0 0 0 0 K02081 0.0 0.1623931623931624 agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor 193.0 78.0 0.0 1.0 1.0 K 0.0 78.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 78.0 0.0 1.0 0.610025799226975 0.746179674642309 0.678102736934642 0.136153875415334 0 0 0 1 K02082 0.0028571428571428 0.0598290598290598 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 266.0 17.0 10.0 2.0 0.708333333333333 M 1.0 23.0 1.0 1.0 COG2222 Fructoselysine-6-P-deglycase_FrlB_or_related_protein,_duplicated_sugar_isomerase_(SIS)_domain AgaS 24.0 0.0416666666666666 0.9583333333333334 0.0714992421183151 0.392515112898197 0.232007177508256 0.3210158707798819 0 0 0 0 K02083 0.0085714285714285 0.1452991452991453 allC; allantoate deiminase [EC:3.5.3.9] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 284.0 56.0 0.0 1.0 1.0 E 3.0 53.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 56.0 0.0535714285714285 0.9464285714285714 0.0060514674134213 0.038413458890626 0.0222324631520236 0.0323619914772047 0 0 0 0 K02084 0.0 0.0028490028490028 APAF1; apoptotic protease-activating factor path:map01524,path:map04115,path:map04210,path:map04214,path:map04215,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05134,path:map05152,path:map05160,path:map05161,path:map05162,path:map05164,path:map05168,path:map05169,path:map05200,path:map05222,path:map05417 Platinum drug resistance,p53 signaling pathway,Apoptosis,Apoptosis - fly,Apoptosis - multiple species,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Legionellosis,Tuberculosis,Hepatitis C,Hepatitis B,Measles,Influenza A,Herpes simplex virus 1 infection,Epstein-Barr virus infection,Pathways in cancer,Small cell lung cancer,Lipid and atherosclerosis 463.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4155 1.0 0.0 1.0 0 0 0 0 K02086 0.0 0.074074074074074 dnaD; DNA replication protein 129.0 23.0 0.0 1.0 1.0 L 0.0 26.0 1.0 1.0 COG3935 DNA_replication_protein_DnaD DnaD 26.0 0.0 1.0 0.0181640871902648 0.0279822763375611 0.0230731817639129 0.0098181891472963 0 0 0 0 K02092 0.0 0.0341880341880341 apcA; allophycocyanin alpha subunit path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 161.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 28I0N 15.0 0.0 1.0 0.001917086210455 0.0087768651390129 0.0053469756747339 0.0068597789285579 0 0 0 0 K02093 0.0 0.0341880341880341 apcB; allophycocyanin beta subunit path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 161.0 14.0 12.0 2.0 0.875 C 0.0 16.0 1.0 1.0 28I0N 16.0 0.0 1.0 0.0001576486279795 0.0012215588340386 0.000689603731009 0.0010639102060591 0 0 0 0 K02094 0.0 0.0341880341880341 apcC; phycobilisome core linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 67.0 11.0 10.0 2.0 0.916666666666667 S 0.0 12.0 1.0 1.0 2CHHF 12.0 0.0 1.0 0.0032694114752752 0.0040178544291569 0.003643632952216 0.0007484429538816 0 0 0 0 K02095 0.0 0.0341880341880341 apcD; allophycocyanin-B path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 158.0 14.0 10.0 2.0 0.777777777777778 C 0.0 18.0 1.0 1.0 28I0N 18.0 0.0 1.0 0.0055055537578732 0.0068532392133376 0.0061793964856054 0.0013476854554644 0 0 0 0 K02096 0.0 0.0398860398860398 apcE; phycobilisome core-membrane linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 438.0 13.0 8.0 3.0 0.68421052631579 GH 0.0 19.0 2.0 0.842105263157895 COG0237 Dephospho-CoA_kinase CoaE 19.0 0.0 1.0 0.0194231885547149 0.0579768528445283 0.0387000206996216 0.0385536642898134 0 0 0 0 K02097 0.0 0.0313390313390313 apcF; phycobilisome core component path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 169.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 28I0N 11.0 0.0 1.0 0.0019055487331422 0.0024234343226981 0.0021644915279201 0.0005178855895559 0 0 0 0 K02099 0.0 0.0598290598290598 araC; AraC family transcriptional regulator, arabinose operon regulatory protein 101.0 22.0 21.0 3.0 0.916666666666667 K 0.0 24.0 4.0 0.625 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 24.0 0.0 1.0 0.0121488155328743 0.0261963859408372 0.0191726007368557 0.0140475704079628 0 0 0 0 K02100 0.0 0.0341880341880341 araE; MFS transporter, SP family, arabinose:H+ symporter 413.0 15.0 13.0 3.0 0.789473684210526 EGP 0.0 19.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 19.0 0.0 1.0 0 0 0 0 K02101 0.0171428571428571 0.0085470085470085 araL; sugar-phosphatase [EC:3.1.3.23] 236.0 9.0 0.0 1.0 1.0 G 6.0 3.0 1.0 1.0 COG0647 Ribonucleotide_monophosphatase_NagD,_HAD_superfamily NagD 9.0 0.6666666666666666 0.3333333333333333 0.0996875755052659 0.223422995666377 0.1615552855858214 0.1237354201611111 0 0 0 0 K02103 0.0028571428571428 0.0769230769230769 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor 97.0 56.0 47.0 2.0 0.861538461538462 K 1.0 63.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 64.0 0.015625 0.984375 0.0025181068845575 0.0024216862094792 0.0024698965470183 9.642067507829996e-05 0 0 0 0 K02106 0.0685714285714285 0.0883190883190883 atoE; short-chain fatty acids transporter path:map02020 Two-component system 371.0 65.0 0.0 1.0 1.0 I 30.0 35.0 1.0 1.0 COG2031 Short_chain_fatty_acids_transporter AtoE 65.0 0.4615384615384615 0.5384615384615384 0.0038721245754688 0.0158640103934075 0.0098680674844381 0.0119918858179386 0 0 0 0 K02107 0.2342857142857143 0.0256410256410256 ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 90.0 82.0 79.0 2.0 0.964705882352941 C 83.0 11.0 4.0 0.936170212765958 COG2811 Archaeal/vacuolar-type_H+-ATPase_subunit_H NtpH 94.0 0.8829787234042553 0.1170212765957446 0.440778024652854 0.843666512576594 0.642222268614724 0.40288848792374 0 0 0 0 K02108 0.0085714285714285 0.8717948717948718 ATPF0A, atpB; F-type H+-transporting ATPase subunit a path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 85.0 335.0 334.0 2.0 0.99702380952381 C 3.0 333.0 1.0 1.0 COG0356 FoF1-type_ATP_synthase,_membrane_subunit_a AtpB 336.0 0.0089285714285714 0.9910714285714286 0.385678482670635 0.911688674646435 0.648683578658535 0.5260101919758 0 0 0 0 K02109 0.0085714285714285 0.8176638176638177 ATPF0B, atpF; F-type H+-transporting ATPase subunit b path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 25.0 424.0 419.0 2.0 0.988344988344988 C 3.0 428.0 3.0 0.923433874709977 COG0711 FoF1-type_ATP_synthase,_membrane_subunit_b_or_b' AtpF 431.0 0.0069605568445475 0.9930394431554525 0.0086866250114031 0.0337209624800585 0.0212037937457308 0.0250343374686554 0 0 0 0 K02110 0.0257142857142857 0.8518518518518519 ATPF0C, atpE; F-type H+-transporting ATPase subunit c path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 55.0 319.0 308.0 5.0 0.949404761904762 C 9.0 327.0 5.0 0.985119047619048 COG0636 FoF1-type_ATP_synthase,_membrane_subunit_c/Archaeal/vacuolar-type_H+-ATPase,_subunit_K AtpE 336.0 0.0267857142857142 0.9732142857142856 0.0079850777643106 0.454193908785419 0.2310894932748648 0.4462088310211083 0 0 0 0 K02111 0.0085714285714285 0.8660968660968661 ATPF1A, atpA; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 425.0 278.0 222.0 2.0 0.832335329341317 C 3.0 331.0 1.0 1.0 COG0056 FoF1-type_ATP_synthase,_alpha_subunit AtpA 334.0 0.0089820359281437 0.9910179640718564 0.22021912879851 0.974132768082346 0.597175948440428 0.7539136392838359 0 0 0 0 K02112 0.0085714285714285 0.8746438746438746 ATPF1B, atpD; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 431.0 276.0 219.0 2.0 0.828828828828829 C 3.0 330.0 1.0 1.0 COG0055 FoF1-type_ATP_synthase,_beta_subunit AtpD 333.0 0.009009009009009 0.990990990990991 0.942150679410323 0.793318453996311 0.867734566703317 0.1488322254140121 0 0 1 1 K02113 0.0 0.792022792022792 ATPF1D, atpH; F-type H+-transporting ATPase subunit delta path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 38.0 299.0 290.0 2.0 0.970779220779221 C 0.0 308.0 3.0 0.905844155844156 COG0712 FoF1-type_ATP_synthase,_delta_subunit AtpH 308.0 0.0 1.0 0.0068412754022823 0.0860510974612942 0.0464461864317882 0.0792098220590119 0 0 0 0 K02114 0.0085714285714285 0.8575498575498576 ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 59.0 324.0 323.0 2.0 0.996923076923077 C 3.0 322.0 1.0 1.0 COG0355 FoF1-type_ATP_synthase,_epsilon_subunit AtpC 325.0 0.0092307692307692 0.9907692307692308 0.0120708213451166 0.0990708338740324 0.0555708276095745 0.0870000125289158 0 0 0 0 K02115 0.0085714285714285 0.8689458689458689 ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma path:map00190,path:map00195,path:map01100 Oxidative phosphorylation,Photosynthesis,Metabolic pathways 165.0 317.0 303.0 3.0 0.954819277108434 C 3.0 329.0 2.0 0.996987951807229 COG0224 FoF1-type_ATP_synthase,_gamma_subunit AtpG 332.0 0.0090361445783132 0.9909638554216867 0.313232611577759 0.565375834886285 0.439304223232022 0.2521432233085259 0 0 0 0 K02116 0.02 0.3817663817663818 atpI; ATP synthase protein I 27.0 101.0 59.0 3.0 0.701388888888889 S 7.0 149.0 18.0 0.474358974358974 COG5336 FoF1-type_ATP_synthase_AtpZ/Atp1/AtpQ_subunit,_putative_Ca2+/Mg2+_transporter AtpZ 156.0 0.0448717948717948 0.9551282051282052 0.0174612200350071 0.0084731037642314 0.0129671618996192 0.0089881162707757 0 0 0 0 K02117 0.7771428571428571 0.1965811965811965 ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 469.0 342.0 312.0 3.0 0.909574468085106 C 295.0 81.0 3.0 0.98936170212766 COG1155 Archaeal/vacuolar-type_H+-ATPase_catalytic_subunit_A/Vma1 NtpA 376.0 0.7845744680851063 0.2154255319148936 0.975051615753914 0.945974489524349 0.9605130526391314 0.0290771262295649 1 1 1 1 K02118 0.7771428571428571 0.1937321937321937 ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 433.0 372.0 370.0 2.0 0.994652406417112 C 295.0 79.0 1.0 1.0 COG1156 Archaeal/vacuolar-type_H+-ATPase_subunit_B/Vma2 NtpB 374.0 0.7887700534759359 0.2112299465240641 0.941986976456755 0.947638066763663 0.944812521610209 0.005651090306908 1 1 1 1 K02119 0.6942857142857143 0.1282051282051282 ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 74.0 322.0 0.0 1.0 1.0 C 268.0 54.0 1.0 1.0 COG1527 Archaeal/vacuolar-type_H+-ATPase_subunit_C/Vma6 NtpC 322.0 0.8322981366459627 0.1677018633540372 0.0670847386781427 0.276864385923425 0.1719745623007838 0.2097796472452823 0 0 0 0 K02120 0.7885714285714286 0.1937321937321937 ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 146.0 372.0 0.0 1.0 1.0 C 294.0 78.0 1.0 1.0 COG1394 Archaeal/vacuolar-type_H+-ATPase_subunit_D/Vma8 NtpD 372.0 0.7903225806451613 0.2096774193548387 0.189793227891369 0.0018292806749715 0.0958112542831702 0.1879639472163974 0 0 0 0 K02121 0.6057142857142858 0.1481481481481481 ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 55.0 279.0 277.0 3.0 0.98936170212766 C 224.0 59.0 4.0 0.985865724381626 COG1390 Archaeal/vacuolar-type_H+-ATPase_subunit_E/Vma4 NtpE 283.0 0.7915194346289752 0.2084805653710247 0.194492007641004 0.402731633446741 0.2986118205438725 0.208239625805737 0 0 0 0 K02122 0.6971428571428572 0.1253561253561253 ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 52.0 307.0 0.0 1.0 1.0 C 256.0 51.0 1.0 1.0 COG1436 Archaeal/vacuolar-type_H+-ATPase_subunit_F/Vma7 NtpF 307.0 0.8338762214983714 0.1661237785016286 0.161202603884421 0.383021771971112 0.2721121879277665 0.2218191680866909 0 0 0 0 K02123 0.7714285714285715 0.1965811965811965 ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 136.0 343.0 304.0 2.0 0.897905759162303 C 301.0 81.0 1.0 1.0 COG1269 Archaeal/vacuolar-type_H+-ATPase_subunit_I/STV1 NtpI 382.0 0.7879581151832461 0.2120418848167539 0.988008558969055 0.985623333437889 0.986815946203472 0.002385225531166 1 1 1 1 K02124 0.7028571428571428 0.1965811965811965 ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 48.0 345.0 339.0 3.0 0.969101123595506 C 270.0 85.0 1.0 1.0 COG0636 FoF1-type_ATP_synthase,_membrane_subunit_c/Archaeal/vacuolar-type_H+-ATPase,_subunit_K AtpE 355.0 0.7605633802816901 0.2394366197183098 0.821318579183154 0.112002653489133 0.4666606163361435 0.709315925694021 1 1 1 1 K02133 0.0 0.0028490028490028 ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2] path:map00190,path:map01100,path:map04714,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 132.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0055 FoF1-type_ATP_synthase,_beta_subunit AtpD 1.0 0.0 1.0 0 0 0 0 K02137 0.0 0.0028490028490028 ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O path:map00190,path:map01100,path:map04714,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 129.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0712 FoF1-type_ATP_synthase,_delta_subunit AtpH 1.0 0.0 1.0 0 0 0 0 K02150 0.0028571428571428 0.0 ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E path:map00190,path:map01100,path:map04145,path:map04150,path:map04721,path:map04966,path:map05110,path:map05120,path:map05165,path:map05323 Oxidative phosphorylation,Metabolic pathways,Phagosome,mTOR signaling pathway,Synaptic vesicle cycle,Collecting duct acid secretion,Vibrio cholerae infection,Epithelial cell signaling in Helicobacter pylori infection,Human papillomavirus infection,Rheumatoid arthritis 207.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG1390 Archaeal/vacuolar-type_H+-ATPase_subunit_E/Vma4 NtpE 1.0 1.0 0.0 0 0 0 0 K02154 0.0057142857142857 0.0 ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a path:map00190,path:map01100,path:map04142,path:map04145,path:map04721,path:map04966,path:map05110,path:map05120,path:map05152,path:map05165,path:map05323 Oxidative phosphorylation,Metabolic pathways,Lysosome,Phagosome,Synaptic vesicle cycle,Collecting duct acid secretion,Vibrio cholerae infection,Epithelial cell signaling in Helicobacter pylori infection,Tuberculosis,Human papillomavirus infection,Rheumatoid arthritis 222.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 COG3642 tRNA_A-37_threonylcarbamoyl_transferase_component_Bud32 Bud32 2.0 1.0 0.0 0 0 0 0 K02155 0.0057142857142857 0.0 ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit path:map00190,path:map01100,path:map04142,path:map04145,path:map04721,path:map04966,path:map05110,path:map05120,path:map05152,path:map05165,path:map05323 Oxidative phosphorylation,Metabolic pathways,Lysosome,Phagosome,Synaptic vesicle cycle,Collecting duct acid secretion,Vibrio cholerae infection,Epithelial cell signaling in Helicobacter pylori infection,Tuberculosis,Human papillomavirus infection,Rheumatoid arthritis 147.0 1.0 0.0 2.0 0.5 C 2.0 0.0 1.0 1.0 COG0636 FoF1-type_ATP_synthase,_membrane_subunit_c/Archaeal/vacuolar-type_H+-ATPase,_subunit_K AtpE 2.0 1.0 0.0 0 0 0 0 K02160 0.0314285714285714 0.6296296296296297 accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein path:map00061,path:map00620,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Pyruvate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 65.0 263.0 240.0 2.0 0.91958041958042 I 12.0 274.0 5.0 0.86013986013986 COG0511 Biotin_carboxyl_carrier_protein AccB 286.0 0.0419580419580419 0.958041958041958 0.005922176035728 0.001034505007296 0.003478340521512 0.0048876710284319 0 0 0 0 K02164 0.0 0.0341880341880341 norE; nitric oxide reductase NorE protein 170.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG1845 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_3 CyoC 12.0 0.0 1.0 0.124925937354173 0.265643327119562 0.1952846322368675 0.140717389765389 0 0 0 0 K02167 0.0 0.0569800569800569 betI; TetR/AcrR family transcriptional regulator, transcriptional repressor of bet genes 166.0 22.0 0.0 1.0 1.0 K 0.0 22.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 22.0 0.0 1.0 0.0080436447685098 0.0182135511316377 0.0131285979500737 0.0101699063631278 0 0 0 0 K02168 0.0514285714285714 0.168091168091168 betT, betS; choline/glycine/proline betaine transport protein 408.0 89.0 69.0 3.0 0.780701754385965 M 27.0 87.0 1.0 1.0 COG1292 Choline-glycine_betaine_transporter BetT 114.0 0.2368421052631578 0.7631578947368421 0.0172490297014977 0.102670342362525 0.0599596860320113 0.0854213126610272 0 0 0 0 K02169 0.0457142857142857 0.3048433048433048 bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 29.0 70.0 32.0 9.0 0.432098765432099 H 16.0 131.0 12.0 0.45679012345679 COG0500 SAM-dependent_methyltransferase SmtA 147.0 0.1088435374149659 0.891156462585034 0.0212448885860109 0.112371341415951 0.0668081150009809 0.0911264528299401 0 0 0 0 K02170 0.0114285714285714 0.131054131054131 bioH; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 85.0 22.0 6.0 6.0 0.44 S 4.0 46.0 7.0 0.34 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 50.0 0.08 0.92 0.102265627849097 0.340368287533058 0.2213169576910774 0.238102659683961 0 0 0 0 K02171 0.0 0.0541310541310541 blaI; BlaI family transcriptional regulator, penicillinase repressor path:map01501 beta-Lactam resistance 108.0 24.0 0.0 1.0 1.0 K 0.0 24.0 1.0 1.0 COG3682 Transcriptional_regulator,_CopY/TcrY_family CopY 24.0 0.0 1.0 0.0129446946626898 0.0156037472126122 0.014274220937651 0.0026590525499223 0 0 0 0 K02172 0.0 0.0683760683760683 blaR1; bla regulator protein blaR1 path:map01501 beta-Lactam resistance 32.0 17.0 10.0 8.0 0.5 KT 0.0 40.0 8.0 0.531914893617021 COG4219 Signal_transducer_regulating_beta-lactamase_production,_contains_metallopeptidase_domain MecR1 40.0 0.0 1.0 0.166352307118992 0.0033441411546142 0.0848482241368031 0.1630081659643777 0 0 0 0 K02173 0.0 0.0142450142450142 yggC; putative kinase 217.0 4.0 3.0 2.0 0.8 H 0.0 5.0 1.0 1.0 COG1072 Panthothenate_kinase CoaA 5.0 0.0 1.0 0.110187077156401 0.253615602219204 0.1819013396878024 0.143428525062803 0 0 0 0 K02182 0.0457142857142857 0.1367521367521367 caiC; carnitine-CoA ligase [EC:6.2.1.48] 238.0 88.0 82.0 2.0 0.936170212765957 IQ 18.0 76.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 94.0 0.1914893617021276 0.8085106382978723 0.0037574493950905 0.036426577471966 0.0200920134335282 0.0326691280768755 0 0 0 0 K02183 0.0028571428571428 0.0028490028490028 CALM; calmodulin path:map04014,path:map04015,path:map04016,path:map04020,path:map04022,path:map04024,path:map04070,path:map04114,path:map04218,path:map04261,path:map04270,path:map04371,path:map04625,path:map04626,path:map04713,path:map04720,path:map04722,path:map04728,path:map04740,path:map04744,path:map04745,path:map04750,path:map04910,path:map04912,path:map04915,path:map04916,path:map04921,path:map04922,path:map04924,path:map04925,path:map04970,path:map04971,path:map05010,path:map05012,path:map05022,path:map05031,path:map05034,path:map05133,path:map05152,path:map05163,path:map05167,path:map05170,path:map05200,path:map05214,path:map05417,path:map05418 Ras signaling pathway,Rap1 signaling pathway,MAPK signaling pathway - plant,Calcium signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway,Phosphatidylinositol signaling system,Oocyte meiosis,Cellular senescence,Adrenergic signaling in cardiomyocytes,Vascular smooth muscle contraction,Apelin signaling pathway,C-type lectin receptor signaling pathway,Plant-pathogen interaction,Circadian entrainment,Long-term potentiation,Neurotrophin signaling pathway,Dopaminergic synapse,Olfactory transduction,Phototransduction,Phototransduction - fly,Inflammatory mediator regulation of TRP channels,Insulin signaling pathway,GnRH signaling pathway,Estrogen signaling pathway,Melanogenesis,Oxytocin signaling pathway,Glucagon signaling pathway,Renin secretion,Aldosterone synthesis and secretion,Salivary secretion,Gastric acid secretion,Alzheimer disease,Parkinson disease,Pathways of neurodegeneration - multiple diseases,Amphetamine addiction,Alcoholism,Pertussis,Tuberculosis,Human cytomegalovirus infection,Kaposi sarcoma-associated herpesvirus infection,Human immunodeficiency virus 1 infection,Pathways in cancer,Glioma,Lipid and atherosclerosis,Fluid shear stress and atherosclerosis 65.0 1.0 0.0 2.0 0.5 DTZ 1.0 1.0 1.0 1.0 COG5126 Ca2+-binding_protein,_EF-hand_superfamily FRQ1 2.0 0.5 0.5 0 0 0 0 K02188 0.2285714285714285 0.2649572649572649 cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 181.0 176.0 175.0 2.0 0.994350282485876 H 82.0 95.0 4.0 0.983050847457627 COG1903 Cobalamin_biosynthesis_protein_CbiD_(cobalt-precorrin-5B_C-methyltransferase) CbiD 177.0 0.4632768361581921 0.536723163841808 0.151955161577918 0.052327391573275 0.1021412765755964 0.099627770004643 0 0 0 0 K02189 0.3057142857142857 0.1937321937321937 cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 124.0 179.0 171.0 4.0 0.913265306122449 H 124.0 72.0 7.0 0.903061224489796 COG2073 Cobalamin_biosynthesis_protein_CbiG CbiG 196.0 0.6326530612244898 0.3673469387755102 0.0057906784401699 0.0367404346721807 0.0212655565561753 0.0309497562320108 0 0 0 0 K02190 0.0285714285714285 0.1168091168091168 cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 167.0 69.0 67.0 3.0 0.958333333333333 H 12.0 60.0 3.0 0.861111111111111 COG4822 Cobalamin_biosynthesis_protein_CbiK,_Co2+_chelatase CbiK 72.0 0.1666666666666666 0.8333333333333334 0.0140310272210645 0.10916146679043 0.0615962470057472 0.0951304395693655 0 0 0 0 K02191 0.28 0.0968660968660968 cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 147.0 73.0 42.0 3.0 0.548872180451128 H 99.0 34.0 3.0 0.894736842105263 COG2242 Precorrin-6B_methylase_2 CobL 133.0 0.7443609022556391 0.2556390977443609 0.0025976062357115 0.0133856450821869 0.0079916256589492 0.0107880388464754 0 0 0 0 K02192 0.0114285714285714 0.1025641025641025 bfd; bacterioferritin-associated ferredoxin 30.0 32.0 24.0 2.0 0.8 P 4.0 36.0 2.0 0.8 COG2906 Bacterioferritin-associated_ferredoxin Bfd 40.0 0.1 0.9 0.847261226245292 0.834524764223315 0.8408929952343035 0.0127364620219769 1 1 1 1 K02193 0.1142857142857142 0.2962962962962963 ccmA; heme exporter protein A [EC:7.6.2.5] path:map02010 ABC transporters 98.0 56.0 8.0 4.0 0.358974358974359 V 42.0 114.0 4.0 0.576923076923077 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 156.0 0.2692307692307692 0.7307692307692307 0.002697394005656 0.0200916803705838 0.0113945371881199 0.0173942863649278 0 0 0 0 K02194 0.12 0.2877492877492877 ccmB; heme exporter protein B path:map02010 ABC transporters 172.0 126.0 108.0 3.0 0.868965517241379 O 43.0 102.0 2.0 0.993103448275862 COG2386 ABC-type_transport_system_involved_in_cytochrome_c_biogenesis,_permease_component CcmB 145.0 0.296551724137931 0.7034482758620689 0.273127324951859 0.972665118306644 0.6228962216292515 0.699537793354785 0 0 0 0 K02195 0.1714285714285714 0.3133903133903133 ccmC; heme exporter protein C path:map02010 ABC transporters 145.0 153.0 137.0 3.0 0.864406779661017 O 66.0 113.0 2.0 0.988826815642458 COG0755 ABC-type_transport_system_involved_in_cytochrome_c_biogenesis,_permease_component CcmC 179.0 0.3687150837988827 0.6312849162011173 0.378060608451291 0.855698188241648 0.6168793983464695 0.477637579790357 0 0 0 0 K02196 0.0 0.094017094017094 ccmD; heme exporter protein D path:map02010 ABC transporters 47.0 34.0 0.0 1.0 1.0 U 0.0 34.0 2.0 0.852941176470588 COG3114 Heme_exporter_protein_D CcmD 34.0 0.0 1.0 0.0069203011442486 0.025261285573329 0.0160907933587888 0.0183409844290804 0 0 0 0 K02197 0.1 0.3048433048433048 ccmE; cytochrome c-type biogenesis protein CcmE 52.0 135.0 125.0 2.0 0.931034482758621 O 40.0 109.0 4.0 0.87248322147651 COG2332 Cytochrome_c_biogenesis_protein_CcmE CcmE 149.0 0.2684563758389262 0.7315436241610739 0.255861491821247 0.927022106100767 0.591441798961007 0.6711606142795199 0 0 0 0 K02198 0.1628571428571428 0.3219373219373219 ccmF; cytochrome c-type biogenesis protein CcmF 269.0 211.0 210.0 2.0 0.995283018867924 O 78.0 134.0 3.0 0.938679245283019 COG1138 Cytochrome_c_biogenesis_protein_CcmF CcmF 212.0 0.3679245283018867 0.6320754716981132 0.687715703393972 0.987425203096451 0.8375704532452115 0.2997094997024789 0 1 0 1 K02199 0.0171428571428571 0.2934472934472934 ccmG, dsbE; cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE 57.0 125.0 109.0 2.0 0.886524822695035 CO 7.0 134.0 2.0 0.971631205673759 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 141.0 0.0496453900709219 0.950354609929078 0.0476633031004114 0.212389589542608 0.1300264463215097 0.1647262864421966 0 0 0 0 K02200 0.0142857142857142 0.2649572649572649 ccmH; cytochrome c-type biogenesis protein CcmH 42.0 113.0 64.0 4.0 0.664705882352941 O 8.0 160.0 4.0 0.552941176470588 COG3088 Cytochrome_c-type_biogenesis_protein_CcmH/NrfF NrfF 168.0 0.0476190476190476 0.9523809523809524 0.0031270171062645 0.340239201159724 0.1716831091329942 0.3371121840534595 0 0 0 0 K02201 0.5828571428571429 0.0 E2.7.7.3B; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 100.0 175.0 135.0 3.0 0.799086757990868 H 219.0 0.0 2.0 0.981735159817352 COG1986 Non-canonical_(house-cleaning)_NTP_pyrophosphatase,_all-alpha_NTP-PPase_family YjjX 219.0 1.0 0.0 0.689080023165468 0.88410783172964 0.786593927447554 0.195027808564172 0 0 0 1 K02203 0.0285714285714285 0.0854700854700854 thrH; phosphoserine / homoserine phosphotransferase [EC:3.1.3.3 2.7.1.39] path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 196.0 40.0 0.0 1.0 1.0 E 10.0 30.0 1.0 1.0 COG0560 Phosphoserine_phosphatase SerB 40.0 0.25 0.75 0.0239522149586834 0.101329141356721 0.0626406781577022 0.0773769263980376 0 0 0 0 K02204 0.0428571428571428 0.1937321937321937 thrB2; homoserine kinase type II [EC:2.7.1.39] path:map00260,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 86.0 46.0 5.0 3.0 0.505494505494506 F 16.0 75.0 1.0 1.0 COG2334 Ser/Thr_protein_kinase_RdoA_involved_in_Cpx_stress_response,_MazF_antagonist SrkA 91.0 0.1758241758241758 0.8241758241758241 0.0465024708629896 0.464673107297538 0.2555877890802638 0.4181706364345484 0 0 0 0 K02205 0.0 0.0142450142450142 rocE, rocC; arginine/ornithine permease 451.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0833 Amino_acid_permease LysP 5.0 0.0 1.0 0.0666186220823377 0.1924042936332 0.1295114578577688 0.1257856715508623 0 0 0 0 K02212 0.0028571428571428 0.0 MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3] path:map03030,path:map04110,path:map04111,path:map04113 DNA replication,Cell cycle,Cell cycle - yeast,Meiosis - yeast 675.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG1241 DNA_replicative_helicase_MCM_subunit_Mcm2,_Cdc46/Mcm_family Mcm2 1.0 1.0 0.0 0 0 0 0 K02217 0.1742857142857143 0.2849002849002849 ftnA, ftn; ferritin [EC:1.16.3.2] 147.0 154.0 138.0 2.0 0.905882352941176 P 63.0 107.0 2.0 0.988235294117647 COG1528 Ferritin FtnA 170.0 0.3705882352941176 0.6294117647058823 0.860869846948258 0.960251747404822 0.91056079717654 0.099381900456564 1 1 1 1 K02221 0.0 0.5783475783475783 yggT; YggT family protein 36.0 196.0 172.0 2.0 0.890909090909091 S 0.0 220.0 1.0 1.0 COG0762 Cytochrome_b6_maturation_protein_CCB3/Ycf19_and_related_maturases,_YggT_family Ycf19 220.0 0.0 1.0 0.0009870292844383 0.182468904530288 0.0917279669073631 0.1814818752458497 0 0 0 0 K02224 0.4257142857142857 0.4074074074074074 cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 214.0 324.0 310.0 4.0 0.952941176470588 H 169.0 171.0 6.0 0.935294117647059 COG1797 Cobyrinic_acid_a,c-diamide_synthase CobB 340.0 0.4970588235294118 0.5029411764705882 0.0118817031080825 0.281617407572426 0.1467495553402542 0.2697357044643435 0 0 0 0 K02225 0.0 0.074074074074074 cobC1, cobC; cobalamin biosynthesis protein CobC path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 275.0 25.0 24.0 2.0 0.961538461538462 E 0.0 26.0 1.0 1.0 COG0079 Histidinol-phosphate/aromatic_aminotransferase_or_cobyric_acid_decarboxylase HisC 26.0 0.0 1.0 0.0108498428885698 0.0488595394313969 0.0298546911599833 0.0380096965428271 0 0 0 0 K02226 0.0771428571428571 0.4444444444444444 cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 19.0 218.0 193.0 2.0 0.897119341563786 G 32.0 208.0 2.0 0.897119341563786 COG0406 Broad_specificity_phosphatase_PhoE PhoE 240.0 0.1333333333333333 0.8666666666666667 0.218876642910829 0.447552119732252 0.3332143813215405 0.228675476821423 0 0 0 0 K02227 0.4485714285714285 0.433048433048433 cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 123.0 324.0 321.0 2.0 0.990825688073394 H 162.0 167.0 2.0 0.993920972644377 COG1270 Cobalamin_biosynthesis_protein_CobD/CbiB CbiB 329.0 0.4924012158054711 0.5075987841945289 0.0204798088821536 0.21553555872716 0.1180076838046567 0.1950557498450064 0 0 0 0 K02228 0.0 0.0683760683760683 cobF; precorrin-6A synthase [EC:2.1.1.152] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 224.0 26.0 0.0 1.0 1.0 H 0.0 26.0 2.0 0.923076923076923 COG2243 Precorrin-2_methylase CobF 26.0 0.0 1.0 0.0322270199231846 0.0525122062286497 0.0423696130759171 0.0202851863054651 0 0 0 0 K02229 0.0 0.0826210826210826 cobG; precorrin-3B synthase [EC:1.14.13.83] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 282.0 17.0 4.0 2.0 0.566666666666667 P 0.0 30.0 1.0 1.0 COG0155 Sulfite_reductase,_beta_subunit_(hemoprotein) CysI 30.0 0.0 1.0 0.0102135715164624 0.0219618341649444 0.0160877028407034 0.011748262648482 0 0 0 0 K02230 0.2314285714285714 0.2678062678062678 cobN; cobaltochelatase CobN [EC:6.6.1.2] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 502.0 293.0 286.0 2.0 0.976666666666667 H 174.0 125.0 3.0 0.973333333333333 COG1429 Cobalamin_biosynthesis_protein_CobN,_Mg-chelatase CobN 299.0 0.5819397993311036 0.4180602006688963 0.126867684825939 0.143267279941988 0.1350674823839635 0.016399595116049 0 0 0 0 K02231 0.0114285714285714 0.4558404558404558 cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 88.0 168.0 166.0 3.0 0.982456140350877 H 4.0 167.0 5.0 0.953216374269006 COG2087 Adenosyl_cobinamide_kinase/adenosyl_cobinamide_phosphate_guanylyltransferase CobU 171.0 0.023391812865497 0.9766081871345028 0.0054790133919365 0.528117814605651 0.2667984139987937 0.5226388012137145 0 0 0 0 K02232 0.3914285714285714 0.4159544159544159 cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 292.0 309.0 0.0 1.0 1.0 H 148.0 161.0 6.0 0.938511326860841 COG1492 Cobyric_acid_synthase CobQ 309.0 0.4789644012944983 0.5210355987055016 0.16816781751017 0.979765921915486 0.573966869712828 0.811598104405316 0 0 0 0 K02233 0.4457142857142857 0.4814814814814814 E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 64.0 337.0 0.0 1.0 1.0 H 159.0 178.0 1.0 1.0 COG0368 Cobalamin_synthase_CobS_(adenosylcobinamide-GDP_ribazoletransferase) CobS 337.0 0.4718100890207715 0.5281899109792285 0.072260766768235 0.107272294580195 0.089766530674215 0.03501152781196 0 0 0 0 K02234 0.0 0.1339031339031339 cobW; cobalamin biosynthesis protein CobW 260.0 44.0 41.0 2.0 0.936170212765957 S 0.0 47.0 1.0 1.0 COG0523 Zinc_metallochaperone_YeiR/ZagA_and_related_GTPases,_G3E_family YejR 47.0 0.0 1.0 0.0054559015695767 0.0177003704763192 0.0115781360229479 0.0122444689067424 0 0 0 0 K02236 0.0 0.0911680911680911 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] 181.0 32.0 0.0 1.0 1.0 NOU 0.0 32.0 1.0 1.0 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 32.0 0.0 1.0 0 0 0 0 K02237 0.0 0.0 comEA; competence protein ComEA 236.0 231.0 4.0 0.959349593495935 L 0.0 0.0 6.0 0.972 COG1555 DNA_uptake_protein_ComE_or_related_DNA-binding_protein ComEA 0.0 0 0 0 0 K02238 0.0 0.0 comEC; competence protein ComEC 396.0 363.0 8.0 0.765957446808511 S 0.0 0.0 11.0 0.686653771760155 COG0658 DNA_uptake_channel_protein_ComEC,_N-terminal_domain ComEC 0.0 0 0 0 0 K02239 0.0028571428571428 0.0142450142450142 comER; competence protein ComER 269.0 6.0 0.0 1.0 1.0 E 1.0 5.0 1.0 1.0 COG0345 Pyrroline-5-carboxylate_reductase ProC 6.0 0.1666666666666666 0.8333333333333334 0.011431531899778 0.0446183195843014 0.0280249257420397 0.0331867876845234 0 0 0 0 K02240 0.0 0.0598290598290598 comFA; competence protein ComFA 287.0 22.0 0.0 1.0 1.0 L 0.0 22.0 1.0 1.0 COG4098 Superfamily_II_DNA/RNA_helicase_required_for_DNA_uptake_(late_competence_protein) ComFA 22.0 0.0 1.0 0.0057205392045669 0.143153892907221 0.0744372160558939 0.1374333537026541 0 0 0 0 K02241 0.0 0.0512820512820512 comFB; competence protein ComFB 76.0 22.0 0.0 1.0 1.0 S 0.0 22.0 6.0 0.545454545454545 2DNY2 22.0 0.0 1.0 0.0063633923745238 0.130517248768373 0.0684403205714484 0.1241538563938492 0 0 0 0 K02242 0.0114285714285714 0.2393162393162393 comFC; competence protein ComFC 85.0 64.0 48.0 3.0 0.719101123595506 S 4.0 85.0 1.0 1.0 COG1040 DNA_utilization_protein_ComFC/GntX,_contains_phosphoribosyltransferase_domain ComFC 89.0 0.0449438202247191 0.9550561797752808 0.388835507126998 0.336223014294104 0.362529260710551 0.0526124928328939 0 0 0 0 K02243 0.0028571428571428 0.0598290598290598 comGA; competence protein ComGA 237.0 27.0 0.0 1.0 1.0 NU 1.0 26.0 1.0 1.0 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 27.0 0.037037037037037 0.9629629629629628 0.0061379195121482 0.0117803378180758 0.008959128665112 0.0056424183059276 0 0 0 0 K02244 0.0 0.037037037037037 comGB; competence protein ComGB 314.0 12.0 11.0 2.0 0.923076923076923 NU 0.0 13.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 13.0 0.0 1.0 1.33014895151365e-08 0.0018168345785284 0.0009084239400089 0.0018168212770388 0 0 0 0 K02245 0.0 0.0626780626780626 comGC; competence protein ComGC 59.0 45.0 0.0 1.0 1.0 U 0.0 45.0 1.0 1.0 COG4537 Competence_protein_ComGC ComGC 45.0 0.0 1.0 0.0020591515950629 0.002758678606296 0.0024089151006794 0.0006995270112331 0 0 0 0 K02246 0.0 0.1054131054131054 comGD; competence protein ComGD 19.0 41.0 39.0 2.0 0.953488372093023 NU 0.0 44.0 4.0 0.5 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 44.0 0.0 1.0 0.066847875028704 0.726925393865649 0.3968866344471765 0.660077518836945 0 0 0 0 K02247 0.0 0.0227920227920227 comGE; competence protein ComGE 124.0 8.0 0.0 1.0 1.0 NU 0.0 8.0 2.0 0.875 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 8.0 0.0 1.0 0.330002726308257 0.080480096995936 0.2052414116520965 0.249522629312321 0 0 0 0 K02248 0.0 0.0284900284900284 comGF; competence protein ComGF 123.0 11.0 0.0 1.0 1.0 U 0.0 11.0 1.0 1.0 COG4940 Competence_protein_ComGF ComGF 11.0 0.0 1.0 0.0100036824758499 0.0140825248794086 0.0120431036776292 0.0040788424035587 0 0 0 0 K02249 0.0 0.0028490028490028 comGG; competence protein ComGG 123.0 0.0 1.0 1.0 1.0 29MTY 1.0 0.0 1.0 0 0 0 0 K02250 0.0 0.0256410256410256 comK; competence protein ComK path:map02024 Quorum sensing 111.0 12.0 11.0 2.0 0.923076923076923 K 0.0 13.0 2.0 0.923076923076923 COG4903 Competence_transcription_factor_ComK ComK 13.0 0.0 1.0 2.71412750446874e-07 3.15302265130447e-05 1.590081963174579e-05 3.1258813762597825e-05 0 0 0 0 K02251 0.0028571428571428 0.0085470085470085 comQ; competence protein ComQ path:map02024 Quorum sensing 48.0 4.0 0.0 1.0 1.0 H 1.0 3.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 4.0 0.25 0.75 0.127760121072553 0.274620532334684 0.2011903267036184 0.1468604112621309 0 0 0 0 K02253 0.0 0.0028490028490028 comX; competence protein ComX path:map02020,path:map02024 Two-component system,Quorum sensing 51.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 296ZE 1.0 0.0 1.0 0 0 0 0 K02254 0.0 0.0028490028490028 comZ; competence protein ComZ 63.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2C7Y5 1.0 0.0 1.0 0 0 0 0 K02255 0.0 0.0056980056980056 ftnB; ferritin-like protein 2 164.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG1528 Ferritin FtnA 2.0 0.0 1.0 0 0 0 0 K02257 0.3542857142857142 0.4814814814814814 COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141] path:map00190,path:map00860,path:map01100,path:map01110,path:map01240,path:map04714 Oxidative phosphorylation,Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Thermogenesis 187.0 185.0 26.0 2.0 0.537790697674419 O 157.0 187.0 2.0 0.988372093023256 COG0109 Polyprenyltransferase_(heme_O_synthase) CyoE 344.0 0.4563953488372093 0.5436046511627907 0.315089297854117 0.919242183947703 0.6171657409009099 0.604152886093586 0 0 0 0 K02258 0.0 0.1168091168091168 COX11, ctaG; cytochrome c oxidase assembly protein subunit 11 path:map00190,path:map01100,path:map04714 Oxidative phosphorylation,Metabolic pathways,Thermogenesis 141.0 41.0 0.0 1.0 1.0 O 0.0 41.0 1.0 1.0 COG3175 Cytochrome_c_oxidase_assembly_protein_Cox11 COX11 41.0 0.0 1.0 0.0145078658490559 0.0182724629151774 0.0163901643821166 0.0037645970661214 0 0 0 0 K02259 0.2057142857142857 0.4358974358974359 COX15, ctaA; heme a synthase [EC:1.17.99.9] path:map00190,path:map00860,path:map01100,path:map01110,path:map01240,path:map02020,path:map04714 Oxidative phosphorylation,Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Two-component system,Thermogenesis 112.0 233.0 230.0 3.0 0.983122362869198 O 75.0 162.0 3.0 0.759493670886076 COG1612 Heme_A_synthase CtaA 237.0 0.3164556962025316 0.6835443037974683 0.0207382130004924 0.0832799338490692 0.0520090734247808 0.0625417208485768 0 0 0 0 K02274 0.2571428571428571 0.4786324786324786 coxA, ctaD; cytochrome c oxidase subunit I [EC:7.1.1.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 345.0 445.0 443.0 2.0 0.995525727069351 C 168.0 280.0 4.0 0.986607142857143 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 448.0 0.375 0.625 0.079995209944835 0.557738904460274 0.3188670572025545 0.4777436945154389 0 0 0 0 K02275 0.3657142857142857 0.5327635327635327 coxB, ctaC; cytochrome c oxidase subunit II [EC:7.1.1.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 11.0 511.0 503.0 4.0 0.975190839694656 C 228.0 292.0 13.0 0.843100189035917 COG1622 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_2 CyoA 520.0 0.4384615384615384 0.5615384615384615 0.0177779113432124 0.0415576815129284 0.0296677964280704 0.023779770169716 0 0 0 0 K02276 0.1028571428571428 0.452991452991453 coxC, ctaE; cytochrome c oxidase subunit III [EC:7.1.1.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 87.0 284.0 283.0 2.0 0.996491228070175 C 44.0 241.0 3.0 0.989473684210526 COG1845 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_3 CyoC 285.0 0.1543859649122807 0.8456140350877193 0.0160848725070062 0.0219245928774557 0.0190047326922309 0.0058397203704495 0 0 0 0 K02277 0.08 0.1339031339031339 coxD, ctaF; cytochrome c oxidase subunit IV [EC:7.1.1.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 57.0 60.0 45.0 3.0 0.759493670886076 S 28.0 53.0 13.0 0.333333333333333 arCOG08921 81.0 0.345679012345679 0.654320987654321 0.0037874562229943 0.0250883007197036 0.0144378784713489 0.0213008444967092 0 0 0 0 K02278 0.0971428571428571 0.1566951566951566 cpaA, tadV; prepilin peptidase CpaA [EC:3.4.23.43] 76.0 61.0 25.0 3.0 0.622448979591837 NOU 36.0 62.0 3.0 0.622448979591837 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 98.0 0.3673469387755102 0.6326530612244898 0 0 0 0 K02279 0.0 0.2678062678062678 cpaB, rcpC; pilus assembly protein CpaB 52.0 90.0 63.0 4.0 0.75 U 0.0 120.0 3.0 0.75 COG3745 Flp_pilus_assembly_protein_CpaB CpaB 120.0 0.0 1.0 0.0536770501912251 0.521526956674274 0.2876020034327495 0.4678499064830488 0 0 0 0 K02280 0.0 0.1367521367521367 cpaC, rcpA; pilus assembly protein CpaC 196.0 63.0 62.0 2.0 0.984375 U 0.0 64.0 4.0 0.9375 COG4964 Flp_pilus_assembly_protein,_secretin_CpaC CpaC 64.0 0.0 1.0 0.0351811325324007 0.318452761805653 0.1768169471690268 0.2832716292732523 0 0 0 0 K02281 0.0 0.0227920227920227 cpaD; pilus assembly protein CpaD 213.0 8.0 0.0 1.0 1.0 N 0.0 8.0 1.0 1.0 COG5461 Type_IV_pilus_biogenesis_protein_CpaD/CtpE CpaD 8.0 0.0 1.0 4.63303291583154e-09 3.12505555638987e-07 1.585692942774093e-07 3.0787252272315544e-07 0 0 0 0 K02282 0.0 0.0 cpaE, tadZ; pilus assembly protein CpaE 63.0 16.0 8.0 0.35 D 0.0 0.0 16.0 0.368131868131868 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 0.0 0 0 0 0 K02283 0.0114285714285714 0.3276353276353276 cpaF, tadA; pilus assembly protein CpaF [EC:7.4.2.8] 172.0 194.0 183.0 6.0 0.902325581395349 U 4.0 211.0 4.0 0.897674418604651 COG4962 Pilus_assembly_protein,_ATPase_of_CpaF_family CpaF 215.0 0.0186046511627906 0.9813953488372092 0.0031622437637108 0.888916623349574 0.4460394335566424 0.8857543795858632 0 0 0 0 K02284 0.0 0.0341880341880341 cpcA; phycocyanin alpha chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 162.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 28I0N 13.0 0.0 1.0 0.0002903472904098 0.00344478925092 0.0018675682706648 0.0031544419605102 0 0 0 0 K02285 0.0 0.0341880341880341 cpcB; phycocyanin beta chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 172.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 28I0N 13.0 0.0 1.0 0.0002738451021402 0.0024011863593175 0.0013375157307288 0.0021273412571773 0 0 0 0 K02286 0.0 0.0398860398860398 cpcC; phycocyanin-associated rod linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 248.0 25.0 24.0 2.0 0.961538461538462 H 0.0 26.0 2.0 0.961538461538462 COG0237 Dephospho-CoA_kinase CoaE 26.0 0.0 1.0 0.0022502245617308 0.017535199209086 0.0098927118854084 0.0152849746473552 0 0 0 0 K02287 0.0 0.0398860398860398 cpcD; phycocyanin-associated, rod path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 77.0 10.0 6.0 3.0 0.625 P 0.0 16.0 2.0 0.875 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 16.0 0.0 1.0 0.0106999780748939 0.0307159262194297 0.0207079521471618 0.0200159481445358 0 0 0 0 K02288 0.0 0.0455840455840455 cpcE; phycocyanobilin lyase subunit alpha [EC:4.4.1.32] path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 244.0 16.0 0.0 1.0 1.0 C 0.0 16.0 1.0 1.0 COG1413 HEAT_repeat HEAT 16.0 0.0 1.0 0.006990984492703 0.0098035689328455 0.0083972767127742 0.0028125844401425 0 0 0 0 K02289 0.0 0.0398860398860398 cpcF; phycocyanobilin lyase subunit beta [EC:4.4.1.32] path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 180.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG1413 HEAT_repeat HEAT 15.0 0.0 1.0 0.005277609968128 0.0106524805730084 0.0079650452705682 0.0053748706048804 0 0 0 0 K02290 0.0 0.0341880341880341 cpcG; phycobilisome rod-core linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 213.0 16.0 5.0 2.0 0.592592592592593 G 0.0 27.0 2.0 0.592592592592593 COG0448 Glucose-1-phosphate_adenylyltransferase_(ADP-glucose_pyrophosphorylase) GlgC 27.0 0.0 1.0 0.0043043702951808 0.0069847226968519 0.0056445464960163 0.002680352401671 0 0 0 0 K02291 0.2085714285714285 0.3276353276353276 crtB; 15-cis-phytoene synthase [EC:2.5.1.32] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 89.0 239.0 236.0 2.0 0.987603305785124 I 90.0 152.0 3.0 0.983471074380165 COG1562 Phytoene/squalene_synthetase ERG9 242.0 0.371900826446281 0.628099173553719 4.24783471774478e-05 0.183498688247784 0.0917705832974807 0.1834562099006065 0 0 0 0 K02292 0.0028571428571428 0.0199430199430199 crtO; beta-carotene ketolase (CrtO type) path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 562.0 10.0 0.0 1.0 1.0 Q 1.0 9.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 10.0 0.1 0.9 0.0016259323608745 0.0048680943692097 0.0032470133650421 0.0032421620083352 0 0 0 0 K02293 0.0028571428571428 0.0598290598290598 PDS, crtP; 15-cis-phytoene desaturase [EC:1.3.5.5] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 424.0 13.0 9.0 5.0 0.565217391304348 E 2.0 21.0 7.0 0.434782608695652 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 23.0 0.0869565217391304 0.9130434782608696 0.0372676026760688 0.125022699581972 0.0811451511290204 0.0877550969059032 0 0 0 0 K02294 0.0 0.037037037037037 crtR; beta-carotene hydroxylase [EC:1.14.13.-] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 289.0 13.0 0.0 1.0 1.0 I 0.0 13.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 13.0 0.0 1.0 4.25843527494464e-22 0.0003339806258567 0.0001669903129283 0.0003339806258567 0 0 0 0 K02295 0.0114285714285714 0.0028490028490028 CRY; cryptochrome path:map04710 Circadian rhythm 510.0 4.0 3.0 2.0 0.8 LT 4.0 1.0 1.0 1.0 COG0415 Deoxyribodipyrimidine_photolyase PhrB 5.0 0.8 0.2 0.039231934198866 0.079667020893693 0.0594494775462795 0.040435086694827 0 0 0 0 K02297 0.0057142857142857 0.074074074074074 cyoA; cytochrome o ubiquinol oxidase subunit II [EC:7.1.1.3] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 236.0 29.0 0.0 1.0 1.0 C 2.0 27.0 1.0 1.0 COG1622 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_2 CyoA 29.0 0.0689655172413793 0.9310344827586208 0.0522350834948286 0.44160160241765 0.2469183429562393 0.3893665189228214 0 0 0 0 K02298 0.0057142857142857 0.0883190883190883 cyoB; cytochrome o ubiquinol oxidase subunit I [EC:7.1.1.3] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 517.0 40.0 0.0 1.0 1.0 C 2.0 38.0 1.0 1.0 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 40.0 0.05 0.95 0.0275446332349223 0.109131613351165 0.0683381232930436 0.0815869801162427 0 0 0 0 K02299 0.0 0.1994301994301994 cyoC; cytochrome o ubiquinol oxidase subunit III path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 149.0 76.0 0.0 1.0 1.0 C 0.0 76.0 1.0 1.0 COG1845 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_3 CyoC 76.0 0.0 1.0 0.153431908956582 0.92740248474151 0.540417196849046 0.773970575784928 0 0 0 0 K02300 0.0 0.0626780626780626 cyoD; cytochrome o ubiquinol oxidase subunit IV path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 88.0 23.0 22.0 2.0 0.958333333333333 C 0.0 24.0 2.0 0.958333333333333 COG3125 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_4 CyoD 24.0 0.0 1.0 0.0314332305385494 0.0534051221661798 0.0424191763523646 0.0219718916276304 0 0 0 0 K02302 0.0457142857142857 0.3532763532763532 cysG; uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 180.0 183.0 0.0 1.0 1.0 H 18.0 161.0 2.0 0.950819672131148 COG0007 Uroporphyrinogen-III_methylase_(siroheme_synthase) CysG 179.0 0.1005586592178771 0.8994413407821229 0.0092654827414389 0.191611711646675 0.1004385971940569 0.1823462289052361 0 0 0 0 K02303 0.4114285714285714 0.5242165242165242 cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 114.0 419.0 418.0 2.0 0.997619047619048 H 172.0 248.0 4.0 0.988095238095238 COG0007 Uroporphyrinogen-III_methylase_(siroheme_synthase) CysG 420.0 0.4095238095238095 0.5904761904761905 0.671861679330107 0.457822964315113 0.56484232182261 0.214038715014994 0 1 0 1 K02304 0.4057142857142857 0.3447293447293447 MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 41.0 288.0 287.0 2.0 0.996539792387543 H 147.0 142.0 8.0 0.889273356401384 COG1648 Siroheme_synthase_(precorrin-2_oxidase/ferrochelatase_domain) CysG2 289.0 0.5086505190311419 0.4913494809688581 0.0355106727529101 0.346050643875764 0.190780658314337 0.3105399711228539 0 0 0 0 K02305 0.0085714285714285 0.1054131054131054 norC; nitric oxide reductase subunit C path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 67.0 47.0 46.0 2.0 0.979166666666667 C 3.0 45.0 4.0 0.791666666666667 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 48.0 0.0625 0.9375 0.0944063241530282 0.135390446352257 0.1148983852526425 0.0409841221992288 0 0 0 0 K02313 0.0114285714285714 0.9743589743589745 dnaA; chromosomal replication initiator protein path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 203.0 385.0 383.0 3.0 0.992268041237113 L 4.0 384.0 2.0 0.997422680412371 COG0593 Chromosomal_replication_initiation_ATPase_DnaA DnaA 388.0 0.0103092783505154 0.9896907216494846 0.502198773794126 0.962181451964909 0.7321901128795175 0.459982678170783 0 1 0 1 K02314 0.0514285714285714 0.9829059829059827 dnaB; replicative DNA helicase [EC:5.6.2.3] path:map03030,path:map04112 DNA replication,Cell cycle - Caulobacter 177.0 424.0 423.0 4.0 0.992974238875878 L 20.0 407.0 1.0 1.0 COG0305 Replicative_DNA_helicase DnaB 427.0 0.0468384074941452 0.9531615925058547 0.305647225552109 0.68336663583296 0.4945069306925345 0.377719410280851 0 0 0 0 K02315 0.0085714285714285 0.1937321937321937 dnaC; DNA replication protein DnaC 56.0 97.0 95.0 3.0 0.97 L 4.0 96.0 2.0 0.98 COG1484 DNA_replication_protein_DnaC DnaC 100.0 0.04 0.96 0.0262216415509192 0.796798043091826 0.4115098423213726 0.7705764015409068 0 0 0 0 K02316 0.9114285714285716 0.9743589743589745 dnaG; DNA primase [EC:2.7.7.101] path:map03030 DNA replication 49.0 722.0 717.0 7.0 0.980978260869565 L 346.0 385.0 5.0 0.972826086956522 COG0358 DNA_primase_(bacterial_type) DnaG 731.0 0.4733242134062927 0.5266757865937073 0.175069086429726 0.47500455560757 0.325036821018648 0.2999354691778439 0 0 0 0 K02317 0.0 0.0085470085470085 dnaT; DNA replication protein DnaT path:map03440 Homologous recombination 157.0 1.0 0.0 1.0 1.0 L 0.0 3.0 2.0 0.666666666666667 2A55U 3.0 0.0 1.0 0 0 0 0 K02318 0.0 0.0028490028490028 COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 236.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG0237 Dephospho-CoA_kinase CoaE 1.0 0.0 1.0 0 0 0 0 K02319 0.8657142857142858 0.0 pol; DNA polymerase, archaea type [EC:2.7.7.7] path:map03030 DNA replication 194.0 543.0 540.0 2.0 0.994505494505494 L 546.0 0.0 5.0 0.937728937728938 COG0417 DNA_polymerase_B_elongation_subunit PolB 546.0 1.0 0.0 0.842876307427805 0.916527283270724 0.8797017953492645 0.073650975842919 0 0 1 1 K02322 0.78 0.0 polC; DNA polymerase II large subunit [EC:2.7.7.7] path:map03030 DNA replication 820.0 291.0 0.0 1.0 1.0 L 291.0 0.0 2.0 0.890034364261168 COG1933 Archaeal_DNA_polymerase_II,_large_subunit PolC 291.0 1.0 0.0 0.990523746176989 0.993312910115982 0.9919183281464856 0.0027891639389929 0 0 1 1 K02323 0.8285714285714286 0.0 polB; DNA polymerase II small subunit [EC:2.7.7.7] path:map03030 DNA replication 267.0 300.0 295.0 2.0 0.983606557377049 L 305.0 0.0 4.0 0.960655737704918 COG1311 Archaeal_DNA_polymerase_II,_small_subunit/DNA_polymerase_delta,_subunit_B HYS2 305.0 1.0 0.0 0.675909527625445 0.823338710278043 0.749624118951744 0.1474291826525979 0 0 0 1 K02324 0.0057142857142857 0.0 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] path:map03030,path:map03410,path:map03420 DNA replication,Base excision repair,Nucleotide excision repair 1363.0 2.0 0.0 1.0 1.0 L 2.0 0.0 1.0 1.0 COG0417 DNA_polymerase_B_elongation_subunit PolB 2.0 1.0 0.0 0 0 0 0 K02326 0.0028571428571428 0.0 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] path:map03030,path:map03410,path:map03420 DNA replication,Base excision repair,Nucleotide excision repair 112.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG1594 DNA-directed_RNA_polymerase,_subunit_M/Transcription_elongation_factor_TFIIS RPB9 1.0 1.0 0.0 0 0 0 0 K02334 0.0 0.0256410256410256 dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] 562.0 16.0 0.0 1.0 1.0 L 0.0 16.0 1.0 1.0 COG0749 DNA_polymerase_I,_3'-5'_exonuclease_and_polymerase_domains PolA 16.0 0.0 1.0 0.0312473692755601 0.0655047607255865 0.0483760650005733 0.0342573914500264 0 0 0 0 K02335 0.02 0.9886039886039886 polA; DNA polymerase I [EC:2.7.7.7] path:map03030,path:map03410,path:map03420,path:map03440 DNA replication,Base excision repair,Nucleotide excision repair,Homologous recombination 334.0 419.0 416.0 5.0 0.981264637002342 L 10.0 418.0 9.0 0.77803738317757 COG0258 5'-3'_exonuclease_Xni/ExoIX_(flap_endonuclease) ExoIX 428.0 0.0233644859813084 0.9766355140186916 0.768323311922375 0.68619056698168 0.7272569394520275 0.082132744940695 1 1 1 1 K02336 0.1057142857142857 0.0854700854700854 polB; DNA polymerase II [EC:2.7.7.7] 418.0 72.0 0.0 1.0 1.0 L 41.0 31.0 1.0 1.0 COG0417 DNA_polymerase_B_elongation_subunit PolB 72.0 0.5694444444444444 0.4305555555555556 0.161560297869162 0.176177243091402 0.168868770480282 0.0146169452222399 0 0 0 0 K02337 0.0142857142857142 0.9914529914529916 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 500.0 457.0 0.0 1.0 1.0 L 8.0 449.0 2.0 0.978118161925602 COG0587 DNA_polymerase_III,_alpha_subunit DnaE 457.0 0.0175054704595186 0.9824945295404814 0.174746433911721 0.870149827071662 0.5224481304916915 0.695403393159941 0 0 0 0 K02338 0.0085714285714285 0.9829059829059827 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 125.0 383.0 0.0 1.0 1.0 L 3.0 380.0 1.0 1.0 COG0592 DNA_polymerase_III_sliding_clamp_(beta)_subunit,_PCNA_homolog DnaN 383.0 0.0078328981723237 0.9921671018276762 0.889859684837036 0.937687444314065 0.9137735645755504 0.047827759477029 0 0 1 1 K02339 0.0542857142857142 0.1709401709401709 holC; DNA polymerase III subunit chi [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 32.0 57.0 54.0 2.0 0.95 L 19.0 60.0 3.0 0.721518987341772 COG2927 DNA_polymerase_III,_chi_subunit HolC 79.0 0.240506329113924 0.759493670886076 0.0178338573069824 0.124572188051614 0.0712030226792982 0.1067383307446316 0 0 0 0 K02340 0.0 0.9173789173789174 holA; DNA polymerase III subunit delta [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 18.0 333.0 332.0 2.0 0.997005988023952 L 0.0 331.0 1.0 1.0 COG1466 DNA_polymerase_III,_delta_subunit HolA 331.0 0.0 1.0 0.15398803754433 0.394094592641354 0.274041315092842 0.240106555097024 0 0 0 0 K02341 0.0085714285714285 0.96011396011396 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 15.0 352.0 350.0 4.0 0.98876404494382 L 3.0 352.0 3.0 0.662921348314607 COG0470 DNA_polymerase_III,_delta_prime_subunit HolB 355.0 0.0084507042253521 0.991549295774648 0.0642000140312066 0.556420803509317 0.3103104087702618 0.4922207894781104 0 0 0 0 K02342 0.0 0.0 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 564.0 549.0 9.0 0.935323383084577 L 0.0 0.0 18.0 0.651741293532338 COG0847 DNA_polymerase_III,_epsilon_subunit_or_related_3'-5'_exonuclease DnaQ 0.0 0 0 0 0 K02343 0.0085714285714285 0.9857549857549858 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 103.0 308.0 229.0 9.0 0.766169154228856 L 3.0 400.0 14.0 0.883950617283951 COG2812 DNA_polymerase_III,_gamma/tau_subunits DnaX 403.0 0.0074441687344913 0.9925558312655088 0.444607275624668 0.834566593619738 0.639586934622203 0.3899593179950699 0 0 0 0 K02344 0.0 0.0142450142450142 holD; DNA polymerase III subunit psi [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 132.0 5.0 0.0 1.0 1.0 L 0.0 5.0 1.0 1.0 COG3050 DNA_polymerase_III,_psi_subunit HolD 5.0 0.0 1.0 4.10222026606037e-21 5.1761481962128e-17 2.588279209119703e-17 5.175737974186194e-17 0 0 0 0 K02345 0.0 0.0085470085470085 holE; DNA polymerase III subunit theta [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 72.0 4.0 0.0 1.0 1.0 L 0.0 4.0 1.0 1.0 2CFYS 4.0 0.0 1.0 3.8284788072678597e-16 6.57639331204878e-13 3.290110895428024e-13 6.572564833241512e-13 0 0 0 0 K02346 0.0285714285714285 0.7150997150997151 dinB; DNA polymerase IV [EC:2.7.7.7] 108.0 375.0 372.0 2.0 0.992063492063492 L 10.0 367.0 2.0 0.992063492063492 COG0389 Nucleotidyltransferase/DNA_polymerase_DinP_involved_in_DNA_repair DinP 377.0 0.026525198938992 0.973474801061008 0.491446537644884 0.90212559339759 0.696786065521237 0.410679055752706 0 0 0 0 K02347 0.3457142857142857 0.339031339031339 polX, dpx; DNA polymerase (family X) 385.0 261.0 248.0 2.0 0.952554744525547 L 139.0 135.0 2.0 0.656934306569343 COG1387 Histidinol_phosphatase_or_related_hydrolase_of_the_PHP_family HIS2 274.0 0.5072992700729927 0.4927007299270073 0.608868585884209 0.872876554699871 0.74087257029204 0.264007968815662 0 1 0 1 K02348 0.0028571428571428 0.1737891737891738 elaA; ElaA protein 101.0 54.0 46.0 3.0 0.84375 S 1.0 63.0 2.0 0.984375 COG2153 Predicted_N-acyltransferase,_GNAT_family ElaA 64.0 0.015625 0.984375 0.0023638230241218 0.0124250294228103 0.007394426223466 0.0100612063986884 0 0 0 0 K02349 0.0028571428571428 0.0 POLQ; DNA polymerase theta [EC:2.7.7.7] 886.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 COG0749 DNA_polymerase_I,_3'-5'_exonuclease_and_polymerase_domains PolA 1.0 1.0 0.0 0 0 0 0 K02351 0.0 0.1538461538461538 K02351; putative membrane protein 173.0 34.0 9.0 5.0 0.447368421052632 S 0.0 76.0 4.0 0.736842105263158 COG3336 Cytochrome_c_oxidase_assembly_protein_CtaG CtaG 76.0 0.0 1.0 0.0053476386337752 0.196289549196932 0.1008185939153536 0.1909419105631568 0 0 0 0 K02352 0.0 0.017094017094017 drp35; lactonase [EC:3.1.1.-] 291.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG3386 Sugar_lactone_lactonase_YvrE YvrE 6.0 0.0 1.0 0.131395659366952 0.261237701193354 0.1963166802801529 0.129842041826402 0 0 0 0 K02355 0.0 0.9857549857549858 fusA, GFM, EFG; elongation factor G 478.0 596.0 0.0 1.0 1.0 J 0.0 596.0 1.0 1.0 COG0480 Translation_elongation_factor_EF-G,_a_GTPase FusA 596.0 0.0 1.0 0.918057400367367 0.658693769728792 0.7883755850480796 0.259363630638575 0 0 1 1 K02356 0.0 0.9829059829059827 efp; elongation factor P 140.0 378.0 0.0 1.0 1.0 J 0.0 378.0 1.0 1.0 COG0231 Translation_elongation_factor_P_(EF-P)/translation_initiation_factor_5A_(eIF-5A) Efp 378.0 0.0 1.0 0.573309163448001 0.146415980332091 0.359862571890046 0.4268931831159099 0 0 0 1 K02357 0.0 0.9943019943019944 tsf, TSFM; elongation factor Ts 164.0 353.0 0.0 1.0 1.0 J 0.0 353.0 1.0 1.0 COG0264 Translation_elongation_factor_EF-Ts Tsf 353.0 0.0 1.0 0.900843514049772 0.596312973804086 0.7485782439269291 0.304530540245686 0 0 1 1 K02358 0.0 0.945868945868946 tuf, TUFM; elongation factor Tu path:map04626 Plant-pathogen interaction 277.0 455.0 450.0 4.0 0.984848484848485 J 0.0 462.0 5.0 0.987012987012987 COG0050 Translation_elongation_factor_EF-Tu,_a_GTPase TufA 462.0 0.0 1.0 0.527863538298067 0.975315071129616 0.7515893047138416 0.447451532831549 0 0 0 1 K02359 0.0057142857142857 0.0056980056980056 EGH; beta-1,4-mannosyltransferase [EC:2.4.1.-] path:map04320 Dorso-ventral axis formation 413.0 5.0 0.0 1.0 1.0 M 2.0 3.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 5.0 0.4 0.6 0.149767436693313 0.525737667009544 0.3377525518514285 0.375970230316231 0 0 0 0 K02361 0.0028571428571428 0.1396011396011396 entC; isochorismate synthase [EC:5.4.4.2] path:map00130,path:map01053,path:map01100,path:map01110 Ubiquinone and other terpenoid-quinone biosynthesis,Biosynthesis of siderophore group nonribosomal peptides,Metabolic pathways,Biosynthesis of secondary metabolites 193.0 53.0 50.0 2.0 0.946428571428571 HQ 1.0 55.0 1.0 1.0 COG1169 Isochorismate_synthase_EntC MenF 56.0 0.0178571428571428 0.9821428571428572 0.0051601473448974 0.564414391835799 0.2847872695903482 0.5592542444909016 0 0 0 0 K02362 0.0 0.0313390313390313 entD; enterobactin synthetase component D [EC:6.3.2.14 2.7.8.-] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 151.0 11.0 10.0 2.0 0.916666666666667 Q 0.0 12.0 1.0 1.0 COG2977 4'-phosphopantetheinyl_transferase_EntD_(siderophore_biosynthesis) EntD 12.0 0.0 1.0 0.0025266484259987 0.0090096655785342 0.0057681570022664 0.0064830171525355 0 0 0 0 K02363 0.0085714285714285 0.0712250712250712 entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 466.0 24.0 21.0 3.0 0.8 Q 3.0 27.0 2.0 0.8 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 30.0 0.1 0.9 0.002823547578732 0.0190092096324181 0.010916378605575 0.0161856620536861 0 0 0 0 K02364 0.0057142857142857 0.0484330484330484 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 414.0 20.0 0.0 1.0 1.0 Q 2.0 18.0 3.0 0.9 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 20.0 0.1 0.9 0.0079448259449981 0.024667355026716 0.016306090485857 0.0167225290817179 0 0 0 0 K02371 0.0228571428571428 0.2934472934472934 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 228.0 134.0 128.0 4.0 0.924137931034483 S 14.0 131.0 1.0 1.0 COG2070 NAD(P)H-dependent_flavin_oxidoreductase_YrpB,_nitropropane_dioxygenase_family YrpB 145.0 0.096551724137931 0.903448275862069 0.324770442606515 0.729498078637594 0.5271342606220545 0.404727636031079 0 0 0 0 K02372 0.0028571428571428 0.6866096866096866 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] path:map00061,path:map00780,path:map01100,path:map01212,path:map01240 Fatty acid biosynthesis,Biotin metabolism,Metabolic pathways,Fatty acid metabolism,Biosynthesis of cofactors 47.0 272.0 252.0 3.0 0.928327645051195 I 1.0 292.0 3.0 0.989761092150171 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl_carrier_protein)_dehydratase FabA 293.0 0.0034129692832764 0.9965870307167236 0.0015690043224273 0.0129204456307264 0.0072447249765768 0.0113514413082991 0 0 0 0 K02377 0.08 0.3703703703703703 TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271] path:map00051,path:map00520,path:map00541,path:map01100,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 229.0 162.0 136.0 4.0 0.839378238341969 GM 35.0 158.0 2.0 0.989637305699482 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 193.0 0.1813471502590673 0.8186528497409327 0.141904546317049 0.324085726483711 0.23299513640038 0.182181180166662 0 0 0 0 K02379 0.3085714285714285 0.4102564102564102 fdhD; FdhD protein 97.0 267.0 250.0 4.0 0.933566433566434 C 127.0 159.0 4.0 0.961538461538462 COG1526 Formate_dehydrogenase_assembly_factor_FdhD,_a_sulfurtransferase FdhD 286.0 0.444055944055944 0.5559440559440559 0.395208786750943 0.93617423879226 0.6656915127716015 0.540965452041317 0 0 0 0 K02380 0.0371428571428571 0.094017094017094 fdhE; FdhE protein 87.0 53.0 52.0 2.0 0.981481481481482 O 14.0 40.0 1.0 1.0 COG3058 Formate_dehydrogenase_maturation_protein_FdhE FdhE 54.0 0.2592592592592592 0.7407407407407407 0.0177200671759784 0.101479075390101 0.0595995712830397 0.0837590082141225 0 0 0 0 K02381 0.0 0.0 fdrA; FdrA protein 31.0 0.0 1.0 1.0 C 0.0 0.0 1.0 1.0 COG0074 Succinyl-CoA_synthetase,_alpha_subunit SucD 0.0 0 0 0 0 K02383 0.0 0.0484330484330484 flbB; flagellar protein FlbB 127.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG3334 Flagellar_motility_protein_MotE,_a_chaperone_for_MotC_folding MotE 17.0 0.0 1.0 0.0132959545874699 0.0883257706777503 0.0508108626326101 0.0750298160902804 0 0 0 0 K02384 0.0 0.0056980056980056 flbC; flagellar protein FlbC 439.0 2.0 0.0 1.0 1.0 N 0.0 2.0 1.0 1.0 COG3144 Flagellar_hook-length_control_protein_FliK FliK 2.0 0.0 1.0 0 0 0 0 K02385 0.0 0.1652421652421652 flbD; flagellar protein FlbD 55.0 60.0 0.0 1.0 1.0 N 0.0 60.0 1.0 1.0 COG1582 Swarming_motility_protein_SwrD SwrD 60.0 0.0 1.0 0.275977284086178 0.849377386422709 0.5626773352544435 0.5734001023365309 0 0 0 0 K02386 0.0 0.2962962962962963 flgA; flagellar basal body P-ring formation protein FlgA path:map02040 Flagellar assembly 79.0 99.0 89.0 2.0 0.908256880733945 N 0.0 109.0 1.0 1.0 COG1261 Flagellar_basal_body_P-ring_formation_protein_FlgA FlgA 109.0 0.0 1.0 0.138934510760119 0.19652170115448 0.1677281059572995 0.057587190394361 0 0 0 0 K02387 0.0 0.4017094017094017 flgB; flagellar basal-body rod protein FlgB path:map02040 Flagellar assembly 57.0 154.0 0.0 1.0 1.0 N 0.0 154.0 1.0 1.0 COG1815 Flagellar_basal_body_rod_protein_FlgB FlgB 154.0 0.0 1.0 0.700496138828489 0.878530370962289 0.789513254895389 0.1780342321337999 0 0 0 1 K02388 0.0 0.4188034188034188 flgC; flagellar basal-body rod protein FlgC path:map02040 Flagellar assembly 99.0 173.0 0.0 1.0 1.0 N 0.0 173.0 6.0 0.913294797687861 COG1558 Flagellar_basal_body_rod_protein_FlgC FlgC 173.0 0.0 1.0 0.0658332448812318 0.397095098797931 0.2314641718395814 0.3312618539166991 0 0 0 0 K02389 0.0 0.4017094017094017 flgD; flagellar basal-body rod modification protein FlgD path:map02040 Flagellar assembly 65.0 153.0 149.0 2.0 0.974522292993631 N 0.0 159.0 5.0 0.949685534591195 COG1843 Flagellar_hook-capping_protein_FlgD FlgD 159.0 0.0 1.0 0.0628756384283718 0.539070293295824 0.3009729658620979 0.4761946548674522 0 0 0 0 K02390 0.0 0.4159544159544159 flgE; flagellar hook protein FlgE path:map02040 Flagellar assembly 168.0 189.0 0.0 1.0 1.0 N 0.0 189.0 4.0 0.788359788359788 COG1749 Flagellar_hook_protein_FlgE FlgE 189.0 0.0 1.0 0.175241488492218 0.722542385907735 0.4488919371999765 0.547300897415517 0 0 0 0 K02391 0.0 0.2307692307692307 flgF; flagellar basal-body rod protein FlgF path:map02040 Flagellar assembly 143.0 87.0 0.0 1.0 1.0 N 0.0 87.0 2.0 0.67816091954023 COG4786 Flagellar_basal_body_rod_protein_FlgG FlgG 87.0 0.0 1.0 0.0214684821496089 0.051227908236012 0.0363481951928104 0.0297594260864031 0 0 0 0 K02392 0.0 0.4017094017094017 flgG; flagellar basal-body rod protein FlgG path:map02040 Flagellar assembly 110.0 264.0 0.0 1.0 1.0 N 0.0 264.0 1.0 1.0 COG4786 Flagellar_basal_body_rod_protein_FlgG FlgG 264.0 0.0 1.0 0.455790937749919 0.393451388891794 0.4246211633208565 0.062339548858125 0 0 0 0 K02393 0.0 0.3076923076923077 flgH; flagellar L-ring protein FlgH path:map02040 Flagellar assembly 111.0 118.0 0.0 1.0 1.0 N 0.0 118.0 1.0 1.0 COG2063 Flagellar_basal_body_L-ring_protein_FlgH FlgH 118.0 0.0 1.0 0.434619160841797 0.430862401632573 0.432740781237185 0.003756759209224 0 0 0 0 K02394 0.0 0.3105413105413105 flgI; flagellar P-ring protein FlgI path:map02040 Flagellar assembly 276.0 114.0 0.0 1.0 1.0 N 0.0 114.0 1.0 1.0 COG1706 Flagellar_basal_body_P-ring_protein_FlgI FlgI 114.0 0.0 1.0 0.533781386256223 0.602349615624629 0.568065500940426 0.068568229368406 0 0 0 1 K02395 0.0028571428571428 0.2621082621082621 flgJ; peptidoglycan hydrolase FlgJ path:map02040 Flagellar assembly 12.0 44.0 15.0 8.0 0.379310344827586 MNO 1.0 108.0 9.0 0.431034482758621 COG3951 Rod_binding_protein_domain FlgJ1 109.0 0.0091743119266055 0.9908256880733946 0 0 0 0 K02396 0.0028571428571428 0.4245014245014245 flgK; flagellar hook-associated protein 1 path:map02040 Flagellar assembly 89.0 172.0 171.0 4.0 0.982857142857143 N 1.0 174.0 7.0 0.925714285714286 COG1256 Flagellar_hook-associated_protein_FlgK FlgK 175.0 0.0057142857142857 0.9942857142857144 0.328402504386628 0.385403108627663 0.3569028065071455 0.057000604241035 0 0 0 0 K02397 0.0 0.4017094017094017 flgL; flagellar hook-associated protein 3 FlgL path:map02040 Flagellar assembly 53.0 150.0 149.0 2.0 0.993377483443708 N 0.0 151.0 2.0 0.980132450331126 COG1344 Flagellin_and_related_hook-associated_protein_FlgL FlgL 151.0 0.0 1.0 0.525248636910154 0.350421548856069 0.4378350928831115 0.1748270880540849 0 0 0 1 K02398 0.0 0.2393162393162393 flgM; negative regulator of flagellin synthesis FlgM path:map02020,path:map02025,path:map02026,path:map02040 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Flagellar assembly 39.0 45.0 9.0 3.0 0.529411764705882 N 0.0 85.0 6.0 0.941176470588235 COG2747 Negative_regulator_of_flagellin_synthesis_(anti-sigma28_factor) FlgM 85.0 0.0 1.0 0.0074528408960566 0.0633929635891013 0.0354229022425789 0.0559401226930447 0 0 0 0 K02399 0.0 0.0398860398860398 flgN; flagellar biosynthesis protein FlgN path:map02040 Flagellar assembly 112.0 9.0 4.0 2.0 0.642857142857143 N 0.0 14.0 3.0 0.857142857142857 COG3418 Flagellar_biosynthesis/type_III_secretory_pathway_chaperone_FlgN FlgN 14.0 0.0 1.0 0.0090338340084325 0.0064030721877966 0.0077184530981145 0.0026307618206359 0 0 0 0 K02400 0.0 0.4159544159544159 flhA; flagellar biosynthesis protein FlhA path:map02040 Flagellar assembly 539.0 152.0 146.0 2.0 0.962025316455696 N 0.0 158.0 1.0 1.0 COG1298 Flagellar_biosynthesis_protein_FlhA FlhA 158.0 0.0 1.0 0.219408060408139 0.898924257909967 0.559166159159053 0.679516197501828 0 0 0 0 K02401 0.0028571428571428 0.4358974358974359 flhB; flagellar biosynthesis protein FlhB path:map02040 Flagellar assembly 226.0 145.0 123.0 3.0 0.863095238095238 N 1.0 167.0 1.0 1.0 COG1377 Flagellar_biosynthesis_protein_FlhB FlhB 168.0 0.0059523809523809 0.9940476190476192 0.521742184431302 0.720855269247086 0.6212987268391941 0.1991130848157839 0 0 0 1 K02402 0.0 0.0227920227920227 flhC; flagellar transcriptional activator FlhC path:map02020,path:map02024,path:map02026,path:map02040 Two-component system,Quorum sensing,Biofilm formation - Escherichia coli,Flagellar assembly 175.0 9.0 8.0 2.0 0.9 K 0.0 10.0 3.0 0.8 2DBG4 10.0 0.0 1.0 0.0017282850363303 0.0033523317811711 0.0025403084087507 0.0016240467448408 0 0 0 0 K02403 0.0 0.0227920227920227 flhD; flagellar transcriptional activator FlhD path:map02020,path:map02024,path:map02026,path:map02040 Two-component system,Quorum sensing,Biofilm formation - Escherichia coli,Flagellar assembly 104.0 5.0 0.0 2.0 0.5 K 0.0 10.0 2.0 0.9 2AX91 10.0 0.0 1.0 8.64707176239738e-13 1.71132920334366e-12 1.288018189791699e-12 8.46622027103922e-13 0 0 0 0 K02404 0.0 0.3247863247863248 flhF; flagellar biosynthesis protein FlhF 150.0 115.0 0.0 1.0 1.0 N 0.0 115.0 1.0 1.0 COG1419 Flagellar_biosynthesis_GTPase_FlhF FlhF 115.0 0.0 1.0 0.0248879456501081 0.267899830462378 0.146393888056243 0.2430118848122698 0 0 0 0 K02405 0.0057142857142857 0.4444444444444444 fliA, whiG; RNA polymerase sigma factor FliA path:map02020,path:map02025,path:map02026,path:map02040,path:map05111 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Flagellar assembly,Biofilm formation - Vibrio cholerae 111.0 194.0 193.0 2.0 0.994871794871795 K 2.0 193.0 2.0 0.907692307692308 COG1191 DNA-directed_RNA_polymerase_specialized_sigma_subunit FliA 195.0 0.0102564102564102 0.9897435897435898 0.0385290080413646 0.561028557963926 0.2997787830026453 0.5224995499225614 0 0 0 0 K02406 0.0114285714285714 0.4131054131054131 fliC, hag; flagellin path:map02020,path:map02040,path:map04621,path:map04626,path:map05131,path:map05132,path:map05134 Two-component system,Flagellar assembly,NOD-like receptor signaling pathway,Plant-pathogen interaction,Shigellosis,Salmonella infection,Legionellosis 142.0 322.0 317.0 4.0 0.969879518072289 N 5.0 327.0 5.0 0.966867469879518 COG1344 Flagellin_and_related_hook-associated_protein_FlgL FlgL 332.0 0.0150602409638554 0.9849397590361446 0.0374029239282805 0.597032972392074 0.3172179481601772 0.5596300484637935 0 0 0 0 K02407 0.0457142857142857 0.3675213675213675 fliD; flagellar hook-associated protein 2 path:map02040 Flagellar assembly 29.0 147.0 120.0 2.0 0.844827586206896 N 17.0 157.0 2.0 0.844827586206897 COG1345 Flagellar_capping_protein_FliD FliD 174.0 0.0977011494252873 0.9022988505747126 0.122958189053744 0.126084189907077 0.1245211894804105 0.003126000853333 0 0 0 0 K02408 0.0 0.4045584045584046 fliE; flagellar hook-basal body complex protein FliE path:map02040 Flagellar assembly 54.0 141.0 134.0 2.0 0.952702702702703 N 0.0 148.0 1.0 1.0 COG1677 Flagellar_hook-basal_body_complex_protein_FliE FliE 148.0 0.0 1.0 0.0179688028646062 0.482863534078854 0.2504161684717301 0.4648947312142478 0 0 0 0 K02409 0.0 0.4216524216524216 fliF; flagellar M-ring protein FliF path:map02040 Flagellar assembly 207.0 154.0 147.0 2.0 0.956521739130435 N 0.0 161.0 2.0 0.968944099378882 COG1766 Flagellar_biosynthesis/type_III_secretory_pathway_M-ring_protein_FliF/YscJ FliF 161.0 0.0 1.0 0.0732663093710042 0.107712202686065 0.0904892560285346 0.0344458933150608 0 0 0 0 K02410 0.0 0.4301994301994302 fliG; flagellar motor switch protein FliG path:map02030,path:map02040 Bacterial chemotaxis,Flagellar assembly 249.0 174.0 0.0 1.0 1.0 N 0.0 174.0 1.0 1.0 COG1536 Flagellar_motor_switch_protein_FliG FliG 174.0 0.0 1.0 0.901016448953618 0.812545682367939 0.8567810656607785 0.0884707665856789 0 0 1 1 K02411 0.0 0.3646723646723647 fliH; flagellar assembly protein FliH path:map02040 Flagellar assembly 49.0 109.0 85.0 3.0 0.813432835820895 N 0.0 134.0 1.0 1.0 COG1317 Flagellar_biosynthesis/type_III_secretory_pathway_protein_FliH FliH 134.0 0.0 1.0 0.0116911090322511 0.471416618169007 0.241553863600629 0.4597255091367558 0 0 0 0 K02412 0.0 0.4074074074074074 fliI; flagellum-specific ATP synthase [EC:7.4.2.8] path:map02040 Flagellar assembly 360.0 126.0 100.0 2.0 0.828947368421053 NU 0.0 152.0 1.0 1.0 COG1157 Flagellar_biosynthesis/type_III_secretory_pathway_ATPase_FliI FliI 152.0 0.0 1.0 0.215593005068563 0.300991412534179 0.258292208801371 0.085398407465616 0 0 0 0 K02413 0.0 0.1908831908831909 fliJ; flagellar protein FliJ path:map02040 Flagellar assembly 51.0 55.0 44.0 2.0 0.833333333333333 N 0.0 68.0 5.0 0.926470588235294 COG2882 Flagellar_biosynthesis_chaperone_FliJ FliJ 68.0 0.0 1.0 0.0152771236617409 0.0503889036588352 0.032833013660288 0.0351117799970943 0 0 0 0 K02414 0.0 0.2051282051282051 fliK; flagellar hook-length control protein FliK path:map02040 Flagellar assembly 29.0 68.0 60.0 2.0 0.894736842105263 N 0.0 76.0 3.0 0.881578947368421 COG3144 Flagellar_hook-length_control_protein_FliK FliK 76.0 0.0 1.0 0.0148770146874724 0.187968768934404 0.1014228918109382 0.1730917542469316 0 0 0 0 K02415 0.0 0.3846153846153846 fliL; flagellar protein FliL path:map02040 Flagellar assembly 43.0 154.0 149.0 3.0 0.9625 N 0.0 163.0 5.0 0.938650306748466 COG1580 Flagellar_basal_body-associated_protein_FliL FliL 163.0 0.0 1.0 0.0961994292689223 0.275084705639027 0.1856420674539746 0.1788852763701046 0 0 0 0 K02416 0.0 0.4188034188034188 fliM; flagellar motor switch protein FliM path:map02030,path:map02040 Bacterial chemotaxis,Flagellar assembly 172.0 156.0 155.0 2.0 0.993630573248407 N 0.0 157.0 2.0 0.993630573248408 COG1868 Flagellar_motor_switch_protein_FliM FliM 157.0 0.0 1.0 0.90878988191826 0.339372569746155 0.6240812258322075 0.5694173121721051 0 0 1 1 K02417 0.0 0.4301994301994302 fliN; flagellar motor switch protein FliN path:map02030,path:map02040 Bacterial chemotaxis,Flagellar assembly 41.0 165.0 151.0 4.0 0.868421052631579 N 0.0 190.0 7.0 0.652631578947369 COG1886 Flagellar_motor_switch/type_III_secretory_pathway_protein_FliN FliN 190.0 0.0 1.0 0.124891199795008 0.483109041307045 0.3040001205510265 0.358217841512037 0 0 0 0 K02418 0.0 0.2535612535612536 fliO, fliZ; flagellar protein FliO/FliZ path:map02040 Flagellar assembly 47.0 88.0 87.0 2.0 0.98876404494382 N 0.0 91.0 5.0 0.956043956043956 COG3190 Flagellar_biogenesis_protein_FliO FliO 91.0 0.0 1.0 0.0189707734361668 0.64689015565999 0.3329304645480784 0.6279193822238232 0 0 0 0 K02419 0.0 0.4245014245014245 fliP; flagellar biosynthesis protein FliP path:map02040 Flagellar assembly 176.0 152.0 146.0 2.0 0.962025316455696 N 0.0 158.0 2.0 0.974683544303797 COG1338 Flagellar_biosynthesis_protein_FliP FliP 158.0 0.0 1.0 0.335189266944809 0.599930294548154 0.4675597807464815 0.264741027603345 0 0 0 0 K02420 0.0057142857142857 0.4216524216524216 fliQ; flagellar biosynthesis protein FliQ path:map02040 Flagellar assembly 72.0 144.0 132.0 2.0 0.923076923076923 N 4.0 156.0 2.0 0.975 COG1987 Flagellar_biosynthesis_protein_FliQ FliQ 160.0 0.025 0.975 0.0815173827437495 0.277167550911226 0.1793424668274877 0.1956501681674765 0 0 0 0 K02421 0.0 0.4188034188034188 fliR; flagellar biosynthesis protein FliR path:map02040 Flagellar assembly 173.0 142.0 131.0 3.0 0.91025641025641 N 0.0 156.0 2.0 0.980769230769231 COG1684 Flagellar_biosynthesis_protein_FliR FliR 156.0 0.0 1.0 0.724830118492183 0.859315363688591 0.792072741090387 0.1344852451964079 0 0 0 1 K02422 0.0 0.3532763532763532 fliS; flagellar secretion chaperone FliS path:map02040 Flagellar assembly 54.0 134.0 129.0 2.0 0.964028776978417 N 0.0 139.0 1.0 1.0 COG1516 Flagellin-specific_chaperone_FliS FliS 139.0 0.0 1.0 0.18866084023343 0.565590588539448 0.377125714386439 0.376929748306018 0 0 0 0 K02423 0.0 0.0427350427350427 fliT; flagellar protein FliT path:map02040 Flagellar assembly 88.0 8.0 2.0 4.0 0.5 N 0.0 16.0 7.0 0.375 2E69G 16.0 0.0 1.0 5.03711725331354e-12 0.005632357747602 0.0028161788763195 0.0056323577425648 0 0 0 0 K02424 0.0028571428571428 0.1139601139601139 fliY, tcyA; L-cystine transport system substrate-binding protein path:map02010,path:map02040 ABC transporters,Flagellar assembly 181.0 46.0 43.0 4.0 0.884615384615385 ET 1.0 51.0 4.0 0.884615384615385 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 52.0 0.0192307692307692 0.9807692307692308 0.0028226966469074 0.0130923088685119 0.0079575027577096 0.0102696122216045 0 0 0 0 K02425 0.0 0.0085470085470085 fliZ; regulator of sigma S factor FliZ path:map02026,path:map02040 Biofilm formation - Escherichia coli,Flagellar assembly 166.0 2.0 1.0 2.0 0.666666666666667 N 0.0 3.0 1.0 1.0 2DBMG 3.0 0.0 1.0 0 0 0 0 K02426 0.0485714285714285 0.3048433048433048 sufE; cysteine desulfuration protein SufE 87.0 132.0 131.0 2.0 0.992481203007519 S 17.0 116.0 2.0 0.992481203007519 COG2166 Sulfur_transfer_protein_SufE,_Fe-S_cluster_assembly SufE 133.0 0.1278195488721804 0.8721804511278195 0.0048798298285857 0.0096505186626814 0.0072651742456335 0.0047706888340957 0 0 0 0 K02427 0.5457142857142857 0.2535612535612536 rlmE, rrmJ, ftsJ; 23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166] 129.0 285.0 0.0 1.0 1.0 J 195.0 90.0 2.0 0.996491228070175 COG0293 23S_rRNA_U2552_(ribose-2'-O)-methylase_RlmE/FtsJ RlmE 285.0 0.6842105263157895 0.3157894736842105 0.568365185791474 0.500324755804829 0.5343449707981516 0.0680404299866449 0 1 0 1 K02428 0.7942857142857143 0.9116809116809116 16.0 611.0 480.0 7.0 0.737032569360675 F 289.0 531.0 4.0 0.737032569360676 COG0127 Inosine/xanthosine_triphosphate_pyrophosphatase,_all-alpha_NTP-PPase_family RdgB 820.0 0.3524390243902439 0.6475609756097561 0.307649761166539 0.150954017930781 0.22930188954866 0.156695743235758 0 0 0 0 K02429 0.0 0.1196581196581196 fucP; MFS transporter, FHS family, L-fucose permease 311.0 85.0 84.0 2.0 0.988372093023256 G 0.0 86.0 1.0 1.0 COG0738 Fucose_permease FucP 86.0 0.0 1.0 0.0067482625436276 0.0391269913412275 0.0229376269424275 0.0323787287975999 0 0 0 0 K02430 0.0 0.0227920227920227 fucR; DeoR family transcriptional regulator, L-fucose operon activator 243.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 8.0 0.0 1.0 0.0656826987637574 0.0893153378535816 0.0774990183086695 0.0236326390898242 0 0 0 0 K02431 0.0 0.0769230769230769 fucU, FUOM; L-fucose mutarotase [EC:5.1.3.29] 118.0 30.0 0.0 1.0 1.0 G 0.0 30.0 2.0 0.966666666666667 COG4154 L-fucose_mutarotase/ribose_pyranase,_RbsD/FucU_family FucU 30.0 0.0 1.0 0.0369170840353537 0.0321052716084235 0.0345111778218886 0.0048118124269302 0 0 0 0 K02433 0.62 0.8945868945868946 gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 172.0 772.0 766.0 3.0 0.987212276214834 J 272.0 510.0 1.0 1.0 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 782.0 0.3478260869565217 0.6521739130434783 0.672696022237559 0.852116315064496 0.7624061686510275 0.179420292826937 0 1 0 1 K02434 0.5685714285714286 0.8660968660968661 gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 313.0 517.0 515.0 2.0 0.996146435452794 J 203.0 316.0 2.0 0.998073217726397 COG0064 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_B_subunit GatB 519.0 0.3911368015414258 0.6088631984585742 0.946895005813529 0.778567194124309 0.8627310999689191 0.16832781168922 1 1 1 1 K02435 0.5142857142857142 0.8575498575498576 gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 24.0 478.0 473.0 3.0 0.985567010309278 J 180.0 305.0 2.0 0.997938144329897 COG0721 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_C_subunit GatC 485.0 0.3711340206185567 0.6288659793814433 0.0412199135407118 0.231179996065499 0.1361999548031054 0.1899600825247872 0 0 0 0 K02436 0.0 0.0056980056980056 gatR; DeoR family transcriptional regulator, galactitol utilization operon repressor 12.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 4.0 0.0 1.0 0.0065395773072241 2.1410279481519e-12 0.0032697886546825 0.006539577305083 0 0 0 0 K02437 0.4885714285714285 0.7464387464387464 gcvH, GCSH; glycine cleavage system H protein path:map00260,path:map00630,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 60.0 551.0 547.0 4.0 0.982174688057041 E 247.0 314.0 2.0 0.992869875222816 COG0509 Glycine_cleavage_system_protein_H_(lipoate-binding) GcvH 561.0 0.4402852049910873 0.5597147950089126 0.959043117657666 0.738879819371333 0.8489614685144995 0.220163298286333 1 1 1 1 K02438 0.0 0.1054131054131054 glgX; glycogen debranching enzyme [EC:3.2.1.196] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 501.0 42.0 0.0 1.0 1.0 G 0.0 42.0 3.0 0.904761904761905 COG1523 Pullulanase/glycogen_debranching_enzyme PulA 42.0 0.0 1.0 0.0104479679392824 0.0182296587559929 0.0143388133476376 0.0077816908167104 0 0 0 0 K02439 0.0171428571428571 0.0313390313390313 glpE; thiosulfate sulfurtransferase [EC:2.8.1.1] path:map00920,path:map01100,path:map01110,path:map01120 Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 97.0 16.0 15.0 2.0 0.941176470588235 P 6.0 11.0 1.0 1.0 COG0607 Rhodanese-related_sulfurtransferase PspE 17.0 0.3529411764705882 0.6470588235294118 0.0142779319098915 0.0522614218501013 0.0332696768799964 0.0379834899402097 0 0 0 0 K02440 0.0971428571428571 0.282051282051282 GLPF; glycerol uptake facilitator protein 161.0 89.0 32.0 3.0 0.581699346405229 G 38.0 115.0 1.0 1.0 COG0580 Glycerol_uptake_facilitator_or_related_aquaporin_(Major_Intrinsic_protein_Family) GlpF 153.0 0.2483660130718954 0.7516339869281046 0.0536831117509542 0.713345710687628 0.3835144112192911 0.6596625989366738 0 0 0 0 K02441 0.0028571428571428 0.0769230769230769 glpG; rhomboid protease GlpG [EC:3.4.21.105] 136.0 28.0 0.0 1.0 1.0 S 1.0 27.0 1.0 1.0 COG0705 Membrane-associated_serine_protease,_rhomboid_family GlpG 28.0 0.0357142857142857 0.9642857142857144 0.0082241343881226 0.0170200314740416 0.0126220829310821 0.008795897085919 0 0 0 0 K02442 0.0 0.0113960113960113 glpM; membrane protein GlpM 56.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG3136 Dual-topology_membrane_protein_YdgC,_GlpM_family GlpM 4.0 0.0 1.0 0.038451721479397 0.0849897608770879 0.0617207411782424 0.0465380393976909 0 0 0 0 K02443 0.0 0.0911680911680911 glpP; glycerol uptake operon antiterminator 148.0 41.0 0.0 1.0 1.0 K 0.0 41.0 1.0 1.0 COG1954 Glycerol-3-phosphate_responsive_antiterminator_(mRNA-binding) GlpP 41.0 0.0 1.0 0.413874671977153 0.772402588554601 0.593138630265877 0.358527916577448 0 0 0 0 K02444 0.0142857142857142 0.1595441595441595 glpR; DeoR family transcriptional regulator, glycerol-3-phosphate regulon repressor 173.0 79.0 78.0 2.0 0.9875 K 10.0 70.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 80.0 0.125 0.875 0.403878397824559 0.418737704575798 0.4113080512001785 0.014859306751239 0 0 0 0 K02445 0.0114285714285714 0.1168091168091168 glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter 266.0 51.0 50.0 2.0 0.980769230769231 G 5.0 47.0 1.0 1.0 COG2271 Sugar_phosphate_permease UhpC 52.0 0.0961538461538461 0.903846153846154 0.0592681398337822 0.0793519750241786 0.0693100574289804 0.0200838351903963 0 0 0 0 K02446 0.0885714285714285 0.3076923076923077 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 277.0 148.0 0.0 1.0 1.0 G 31.0 117.0 1.0 1.0 COG1494 Fructose-1,6-bisphosphatase/sedoheptulose_1,7-bisphosphatase_or_related_protein GlpX 148.0 0.2094594594594594 0.7905405405405406 0.0397462322853022 0.775615006031096 0.4076806191581991 0.7358687737457938 0 0 0 0 K02448 0.0057142857142857 0.0655270655270655 norD; nitric oxide reductase NorD protein 376.0 29.0 0.0 1.0 1.0 P 2.0 27.0 1.0 1.0 COG4548 Nitric_oxide_reductase_activation_protein NorD 29.0 0.0689655172413793 0.9310344827586208 0.0434075388572613 0.104529247576997 0.0739683932171291 0.0611217087197357 0 0 0 0 K02450 0.0428571428571428 0.1965811965811965 gspA; general secretion pathway protein A 63.0 82.0 69.0 6.0 0.689075630252101 U 15.0 119.0 14.0 0.671641791044776 COG3267 Type_II_secretory_pathway_ATPase_component_GspA/ExeA/MshM ExeA 134.0 0.1119402985074626 0.8880597014925373 0.0329254521597978 0.11687434227145 0.0748998972156239 0.0839488901116521 0 0 0 0 K02451 0.0085714285714285 0.0598290598290598 gspB; general secretion pathway protein B 67.0 14.0 8.0 4.0 0.56 S 3.0 22.0 13.0 0.16 COG5373 Uncharacterized_membrane_protein 25.0 0.12 0.88 0.0157217221898958 0.0380820665997303 0.026901894394813 0.0223603444098344 0 0 0 0 K02452 0.0 0.1139601139601139 gspC; general secretion pathway protein C path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 89.0 44.0 41.0 2.0 0.936170212765957 U 0.0 47.0 2.0 0.936170212765958 COG3031 Type_II_secretory_pathway,_component_PulC PulC 47.0 0.0 1.0 0.0085606173796129 0.0160936914079618 0.0123271543937873 0.0075330740283489 0 0 0 0 K02453 0.0028571428571428 0.3504273504273504 gspD; general secretion pathway protein D path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 25.0 172.0 132.0 6.0 0.754385964912281 NU 1.0 223.0 12.0 0.710526315789474 COG1450 Type_II_secretory_pathway_component_GspD/PulD_(secretin) PulD 224.0 0.0044642857142857 0.9955357142857144 0.0244709978470509 0.0748391309673418 0.0496550644071963 0.0503681331202909 0 0 0 0 K02454 0.0057142857142857 0.4928774928774929 gspE; general secretion pathway protein E [EC:7.4.2.8] path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 246.0 296.0 0.0 1.0 1.0 NU 3.0 293.0 3.0 0.986486486486486 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 296.0 0.0101351351351351 0.9898648648648648 0.561225983385987 0.931857672471261 0.746541827928624 0.370631689085274 0 0 0 1 K02455 0.0 0.3162393162393162 gspF; general secretion pathway protein F path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 244.0 115.0 72.0 2.0 0.727848101265823 U 0.0 158.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 158.0 0.0 1.0 0.981820548383889 0.913049019080905 0.947434783732397 0.068771529302984 0 0 1 1 K02456 0.0028571428571428 0.4415954415954416 gspG; general secretion pathway protein G path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 5.0 492.0 327.0 2.0 0.748858447488584 NU 2.0 653.0 8.0 0.766666666666667 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 655.0 0.0030534351145038 0.9969465648854962 0.0058397568197782 0.0026419530441512 0.0042408549319647 0.003197803775627 0 0 0 0 K02457 0.0028571428571428 0.188034188034188 gspH; general secretion pathway protein H path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 22.0 76.0 62.0 3.0 0.826086956521739 NU 1.0 92.0 8.0 0.451612903225806 COG4970 Type_IV_pilus_assembly_protein_FimT FimT 93.0 0.010752688172043 0.989247311827957 0.361214791611232 0.0963068660915825 0.2287608288514072 0.2649079255196495 0 0 0 0 K02458 0.0028571428571428 0.1794871794871795 gspI; general secretion pathway protein I path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 21.0 86.0 73.0 3.0 0.86 NU 1.0 100.0 9.0 0.435643564356436 COG4967 Type_IV_pilus_assembly_protein_PilV PilV 101.0 0.0099009900990099 0.99009900990099 0.0245438987917491 0.0720982078918677 0.0483210533418084 0.0475543091001186 0 0 0 0 K02459 0.0 0.1652421652421652 gspJ; general secretion pathway protein J path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 31.0 42.0 4.0 2.0 0.525 U 0.0 81.0 8.0 0.469135802469136 COG4795 Type_II_secretory_pathway,_PulJ/GspJ_component PulJ 81.0 0.0 1.0 0.0284656154617286 0.117862924498583 0.0731642699801558 0.0893973090368544 0 0 0 0 K02460 0.0028571428571428 0.1794871794871795 gspK; general secretion pathway protein K path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 72.0 70.0 65.0 4.0 0.875 U 1.0 80.0 3.0 0.839506172839506 COG3156 Type_II_secretory_pathway,_component_PulK PulK 81.0 0.0123456790123456 0.9876543209876544 0.934887205310755 0.0794267737926342 0.5071569895516946 0.8554604315181208 0 0 1 1 K02461 0.0 0.1367521367521367 gspL; general secretion pathway protein L path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 56.0 38.0 21.0 2.0 0.690909090909091 NU 0.0 55.0 3.0 0.4 COG3166 Type_IV_pilus_assembly_protein_PilN PilN 55.0 0.0 1.0 0.599789617983674 0.0652226735863887 0.3325061457850313 0.5345669443972854 0 0 0 1 K02462 0.0 0.0883190883190883 gspM; general secretion pathway protein M path:map03070,path:map05111 Bacterial secretion system,Biofilm formation - Vibrio cholerae 68.0 27.0 18.0 2.0 0.75 U 0.0 36.0 3.0 0.722222222222222 COG3149 Type_II_secretory_pathway,_component_PulM PulM 36.0 0.0 1.0 0.0274694429344644 0.045518378640464 0.0364939107874641 0.0180489357059996 0 0 0 0 K02463 0.0 0.0626780626780626 gspN; general secretion pathway protein N path:map05111 Biofilm formation - Vibrio cholerae 71.0 14.0 8.0 2.0 0.7 S 0.0 23.0 9.0 0.260869565217391 COG3031 Type_II_secretory_pathway,_component_PulC PulC 23.0 0.0 1.0 0.006425833203368 0.0218260588321146 0.0141259460177412 0.0154002256287465 0 0 0 0 K02464 0.0 0.0341880341880341 gspO; general secretion pathway protein O [EC:3.4.23.43 2.1.1.-] path:map03070 Bacterial secretion system 159.0 11.0 9.0 2.0 0.846153846153846 NOU 0.0 13.0 1.0 1.0 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 13.0 0.0 1.0 0 0 0 0 K02465 0.0 0.0028490028490028 gspS; general secretion pathway protein S path:map03070 Bacterial secretion system 128.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DR0V 1.0 0.0 1.0 0 0 0 0 K02466 0.0 0.0227920227920227 gutM; glucitol operon activator protein 118.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG4578 DNA-binding_transcriptional_regulator_of_glucitol_operon GutM 8.0 0.0 1.0 0.0265454552140206 0.360149606937408 0.1933475310757142 0.3336041517233874 0 0 0 0 K02467 0.0 0.0085470085470085 gutQ; arabinose 5-phosphate isomerase [EC:5.3.1.13] 319.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 1.0 1.0 COG0517 CBS_domain CBS 3.0 0.0 1.0 0 0 0 0 K02468 0.0 0.0056980056980056 srlR, gutR; DeoR family transcriptional regulator, glucitol operon repressor 255.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 2.0 0.0 1.0 0 0 0 0 K02469 0.4828571428571429 0.9857549857549858 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 504.0 603.0 602.0 3.0 0.996694214876033 L 178.0 427.0 3.0 0.991735537190083 COG0188 DNA_gyrase/topoisomerase_IV,_subunit_A GyrA 605.0 0.2942148760330578 0.7057851239669422 0.0346191385370247 0.905993501600069 0.4703063200685468 0.8713743630630443 0 0 0 0 K02470 0.5057142857142857 0.9914529914529916 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 370.0 601.0 596.0 4.0 0.986863711001642 L 193.0 424.0 5.0 0.974068071312804 COG0187 DNA_gyrase/topoisomerase_IV,_subunit_B GyrB 617.0 0.312803889789303 0.6871961102106969 0.938123594358289 0.988579434317467 0.963351514337878 0.050455839959178 1 1 1 1 K02471 0.0 0.1111111111111111 bacA, bclA; vitamin B12/bleomycin/antimicrobial peptide transport system ATP-binding/permease protein path:map02010 ABC transporters 416.0 47.0 41.0 3.0 0.796610169491525 S 0.0 59.0 2.0 0.983050847457627 COG4178 ABC-type_uncharacterized_transport_system,_permease_and_ATPase_components YddA 59.0 0.0 1.0 0.005206197987165 0.0092732636048034 0.0072397307959842 0.0040670656176384 0 0 0 0 K02472 0.38 0.1937321937321937 wecC; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.336] path:map00520,path:map00541,path:map01100,path:map01250,path:map02020,path:map05111 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars,Two-component system,Biofilm formation - Vibrio cholerae 259.0 255.0 241.0 2.0 0.947955390334572 M 185.0 84.0 1.0 1.0 COG0677 UDP-N-acetyl-D-mannosaminuronate_dehydrogenase WecC 269.0 0.6877323420074349 0.312267657992565 0.977841111968067 0.993750599377204 0.9857958556726356 0.015909487409137 1 1 1 1 K02473 0.0857142857142857 0.131054131054131 wbpP; UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine 4-epimerase [EC:5.1.3.7 5.1.3.-] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 232.0 58.0 38.0 2.0 0.743589743589744 M 32.0 46.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 78.0 0.4102564102564102 0.5897435897435898 0.484866429743978 0.650029097589433 0.5674477636667055 0.1651626678454549 0 0 0 0 K02474 0.16 0.3447293447293447 wbpO; UDP-N-acetyl-D-glucosamine/UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.136 1.1.1.-] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 202.0 192.0 178.0 2.0 0.932038834951456 M 65.0 141.0 1.0 1.0 COG0677 UDP-N-acetyl-D-mannosaminuronate_dehydrogenase WecC 206.0 0.3155339805825243 0.6844660194174758 0.900467031717148 0.688706230806424 0.794586631261786 0.211760800910724 1 1 1 1 K02475 0.0028571428571428 0.0683760683760683 K02475; two-component system, CitB family, response regulator 180.0 16.0 7.0 3.0 0.516129032258065 KT 1.0 30.0 1.0 1.0 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 31.0 0.032258064516129 0.967741935483871 0.009570503834659 0.142849921212562 0.0762102125236104 0.133279417377903 0 0 0 0 K02476 0.0 0.074074074074074 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] 392.0 39.0 0.0 1.0 1.0 T 0.0 39.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 39.0 0.0 1.0 0.0032551476622204 0.014548589156207 0.0089018684092137 0.0112934414939866 0 0 0 0 K02477 0.0 0.2165242165242165 K02477; two-component system, LytTR family, response regulator 97.0 70.0 9.0 3.0 0.374331550802139 T 0.0 187.0 1.0 1.0 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 187.0 0.0 1.0 0.0020048875337882 0.0272277533098658 0.014616320421827 0.0252228657760776 0 0 0 0 K02478 0.0114285714285714 0.1652421652421652 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 165.0 72.0 0.0 1.0 1.0 T 12.0 72.0 4.0 0.678571428571429 COG3275 Sensor_histidine_kinase,_LytS/YehU_family LytS 84.0 0.1428571428571428 0.8571428571428571 0.0017102746354295 0.0983459219366113 0.0500280982860204 0.0966356473011818 0 0 0 0 K02479 0.0028571428571428 0.1481481481481481 K02479; two-component system, NarL family, response regulator 158.0 41.0 23.0 3.0 0.594202898550725 K 1.0 68.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 69.0 0.0144927536231884 0.9855072463768116 0.0238492796577098 0.818762094718022 0.4213056871878659 0.7949128150603122 0 0 0 0 K02480 0.0 0.0968660968660968 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] 150.0 45.0 0.0 1.0 1.0 T 0.0 45.0 9.0 0.266666666666667 COG2203 GAF_domain GAF 45.0 0.0 1.0 0.0119386392277434 0.741478423999726 0.3767085316137347 0.7295397847719826 0 0 0 0 K02481 0.0085714285714285 0.2849002849002849 flgR; two-component system, NtrC family, response regulator 263.0 259.0 256.0 2.0 0.988549618320611 T 3.0 259.0 2.0 0.99618320610687 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 262.0 0.0114503816793893 0.9885496183206108 0.0041187049576897 0.0812992126886264 0.042708958823158 0.0771805077309367 0 0 0 0 K02482 0.0257142857142857 0.2649572649572649 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] 56.0 211.0 205.0 3.0 0.967889908256881 T 11.0 205.0 22.0 0.541284403669725 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 216.0 0.0509259259259259 0.949074074074074 0.00373855584589 0.0289835974349941 0.016361076640442 0.025245041589104 0 0 0 0 K02483 0.0342857142857142 0.6296296296296297 K02483; two-component system, OmpR family, response regulator 81.0 280.0 30.0 4.0 0.476190476190476 T 14.0 574.0 2.0 0.996598639455782 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 588.0 0.0238095238095238 0.9761904761904762 0.003230862718518 0.0360139748065918 0.0196224187625549 0.0327831120880737 0 0 0 0 K02484 0.0114285714285714 0.376068376068376 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 69.0 210.0 208.0 5.0 0.972222222222222 T 4.0 212.0 12.0 0.462962962962963 COG0642 Signal_transduction_histidine_kinase BaeS 216.0 0.0185185185185185 0.9814814814814816 0.323231932558219 0.565014471092363 0.444123201825291 0.241782538534144 0 0 0 0 K02485 0.1057142857142857 0.1054131054131054 rssB, hnr; two-component system, response regulator 52.0 97.0 88.0 3.0 0.873873873873874 T 65.0 46.0 8.0 0.621621621621622 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 111.0 0.5855855855855856 0.4144144144144144 0.0055457326569974 0.0085372787153551 0.0070415056861762 0.0029915460583577 0 0 0 0 K02486 0.0714285714285714 0.0142450142450142 K02486; two-component system, sensor kinase [EC:2.7.13.3] 168.0 40.0 0.0 1.0 1.0 T 32.0 8.0 4.0 0.9 COG0642 Signal_transduction_histidine_kinase BaeS 40.0 0.8 0.2 0.0550880638309746 0.135056874798842 0.0950724693149083 0.0799688109678674 0 0 0 0 K02487 0.0057142857142857 0.1652421652421652 11.0 68.0 63.0 11.0 0.739130434782609 T 2.0 89.0 16.0 0.612903225806452 COG0643 Chemotaxis_protein_histidine_kinase_CheA CheA 91.0 0.0219780219780219 0.978021978021978 0.0103980420818234 0.0704101863950746 0.040404114238449 0.0600121443132512 0 0 0 0 K02488 0.0 0.0 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65] path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 161.0 149.0 3.0 0.925287356321839 T 0.0 0.0 11.0 0.390804597701149 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 0.0 0 0 0 0 K02489 0.0 0.0028490028490028 hk1; two-component system, glycerol uptake and utilization sensor kinase [EC:2.7.13.3] path:map02020 Two-component system 834.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 1.0 0.0 1.0 0 0 0 0 K02490 0.02 0.0883190883190883 spo0F; two-component system, response regulator, stage 0 sporulation protein F path:map02020,path:map02024 Two-component system,Quorum sensing 86.0 44.0 41.0 2.0 0.936170212765957 T 11.0 36.0 5.0 0.531914893617021 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 47.0 0.2340425531914893 0.7659574468085106 0.0021065839513409 0.428889604322894 0.2154980941371174 0.4267830203715531 0 0 0 0 K02491 0.0028571428571428 0.0341880341880341 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3] path:map02020 Two-component system 260.0 16.0 0.0 1.0 1.0 T 1.0 15.0 6.0 0.3125 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 16.0 0.0625 0.9375 0.0028960508984433 0.0177868870596242 0.0103414689790337 0.0148908361611809 0 0 0 0 K02492 0.4885714285714285 0.6182336182336182 hemA; glutamyl-tRNA reductase [EC:1.2.1.70] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 152.0 413.0 410.0 2.0 0.992788461538462 H 190.0 226.0 3.0 0.987980769230769 COG0373 Glutamyl-tRNA_reductase HemA 416.0 0.4567307692307692 0.5432692307692307 0.0324753993495774 0.527339804168689 0.2799076017591332 0.4948644048191116 0 0 0 0 K02493 0.7828571428571428 0.9430199430199432 hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297] 10.0 493.0 319.0 2.0 0.739130434782609 J 286.0 376.0 3.0 0.970014992503748 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 662.0 0.43202416918429 0.56797583081571 0.199824553148949 0.932288501183029 0.566056527165989 0.73246394803408 0 0 0 0 K02494 0.0 0.0712250712250712 lolB; outer membrane lipoprotein LolB 116.0 25.0 0.0 1.0 1.0 M 0.0 25.0 1.0 1.0 COG3017 Outer_membrane_lipoprotein_LolB,_involved_in_outer_membrane_biogenesis LolB 25.0 0.0 1.0 0.0012492415683437 0.0026553954760852 0.0019523185222144 0.0014061539077415 0 0 0 0 K02495 0.0057142857142857 0.0512820512820512 hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 428.0 20.0 0.0 1.0 1.0 H 2.0 18.0 1.0 1.0 COG0635 Coproporphyrinogen-III_oxidase_HemN__(oxygen-independent)_or_related_Fe-S_oxidoreductase HemN 20.0 0.1 0.9 0.0568063387077525 0.366114916522255 0.2114606276150037 0.3093085778145025 0 0 0 0 K02496 0.0 0.094017094017094 hemX; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 102.0 32.0 0.0 1.0 1.0 H 0.0 33.0 3.0 0.727272727272727 COG2959 Proteobacterial_HemX_domain,_involved_in_2-ketogluconate_production_(unrelated_to_B._subtilis_HemX,_COG0755,_no_evidence_of_involvement_in_heme_biosynthesis) HemX 33.0 0.0 1.0 0.005911354091473 0.0163118786451342 0.0111116163683036 0.0104005245536612 0 0 0 0 K02497 0.0 0.0313390313390313 hemX; HemX protein 262.0 11.0 0.0 1.0 1.0 O 0.0 11.0 1.0 1.0 COG0755 ABC-type_transport_system_involved_in_cytochrome_c_biogenesis,_permease_component CcmC 11.0 0.0 1.0 0.0009749539216485 3.35694997899969e-07 0.0004876448083232 0.0009746182266506 0 0 0 0 K02498 0.0 0.1595441595441595 hemY; HemY protein 179.0 31.0 6.0 2.0 0.553571428571429 H 0.0 56.0 3.0 0.517857142857143 COG3071 Uncharacterized_protein_HemY,_contains_HemY_N_domain_and_TPR_repeats_(unrelated_to_protoporphyrinogen_oxidase_HemY) HemYx 56.0 0.0 1.0 0.0057267472496913 0.0081022430437013 0.0069144951466963 0.00237549579401 0 0 0 0 K02499 0.02 0.5470085470085471 yabN; tetrapyrrole methylase family protein / MazG family protein 125.0 166.0 138.0 4.0 0.813725490196078 S 7.0 197.0 1.0 1.0 COG1694 NTP_pyrophosphatase,_house-cleaning_of_non-canonical_NTPs MazG 204.0 0.034313725490196 0.965686274509804 0.840600736359665 0.703481209508519 0.772040972934092 0.137119526851146 1 1 1 1 K02500 0.5171428571428571 0.7606837606837606 hisF; imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 214.0 485.0 483.0 2.0 0.995893223819302 E 196.0 291.0 2.0 0.995893223819302 COG0107 Imidazole_glycerol_phosphate_synthase_subunit_HisF HisF 487.0 0.4024640657084189 0.5975359342915811 0.223539794580793 0.787333446501509 0.505436620541151 0.5637936519207161 0 0 0 0 K02501 0.5171428571428571 0.7435897435897436 hisH; imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 97.0 468.0 467.0 2.0 0.997867803837953 E 189.0 280.0 2.0 0.997867803837953 COG0118 Imidazoleglycerol_phosphate_synthase_glutamine_amidotransferase_subunit_HisH HisH 469.0 0.4029850746268656 0.5970149253731343 0.146991393268763 0.244702340013185 0.195846866640974 0.0977109467444219 0 0 0 0 K02502 0.0457142857142857 0.4301994301994302 hisZ; ATP phosphoribosyltransferase regulatory subunit path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 52.0 157.0 135.0 4.0 0.773399014778325 E 19.0 183.0 4.0 0.571428571428571 COG3705 ATP_phosphoribosyltransferase_regulatory_subunit_HisZ HisZ 202.0 0.094059405940594 0.905940594059406 0.0005362596254602 0.0016874929260026 0.0011118762757313 0.0011512333005424 0 0 0 0 K02503 0.68 0.8717948717948718 HINT1, hinT, hit; histidine triad (HIT) family protein 28.0 491.0 291.0 3.0 0.709537572254335 FG 339.0 353.0 1.0 1.0 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 692.0 0.4898843930635838 0.5101156069364162 0.0108447282686186 0.133031998663987 0.0719383634663028 0.1221872703953683 0 0 0 0 K02504 0.0 0.0313390313390313 hofB; protein transport protein HofB 454.0 11.0 0.0 1.0 1.0 NU 0.0 11.0 1.0 1.0 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 11.0 0.0 1.0 1.1704709668780698e-11 1.6159881482288798e-11 1.3932295575534748e-11 4.4551718135081e-12 0 0 0 0 K02505 0.0 0.0284900284900284 hofC; protein transport protein HofC 314.0 8.0 4.0 2.0 0.666666666666667 U 0.0 12.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 12.0 0.0 1.0 0.0322076150466138 0.0281328927237406 0.0301702538851771 0.0040747223228732 0 0 0 0 K02506 0.0 0.0455840455840455 hofD, hopD; leader peptidase HopD [EC:3.4.23.43] 199.0 15.0 14.0 2.0 0.9375 NOU 0.0 16.0 1.0 1.0 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 16.0 0.0 1.0 0 0 0 0 K02507 0.0 0.0683760683760683 hofQ; protein transport protein HofQ 285.0 27.0 0.0 1.0 1.0 U 0.0 27.0 1.0 1.0 COG4796 Type_II_secretory_pathway,_component_HofQ HofQ 27.0 0.0 1.0 0.95868569308453 0.870400887545392 0.9145432903149612 0.0882848055391379 0 0 1 1 K02508 0.0 0.0113960113960113 hpaA; AraC family transcriptional regulator, 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein 79.0 3.0 2.0 2.0 0.75 K 0.0 4.0 2.0 0.75 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 4.0 0.0 1.0 0.064451842690871 0.132975307066101 0.098713574878486 0.06852346437523 0 0 0 0 K02509 0.0314285714285714 0.0455840455840455 hpaH; 2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 169.0 21.0 0.0 1.0 1.0 Q 13.0 19.0 2.0 0.59375 COG3971 2-keto-4-pentenoate_hydratase MhpD 32.0 0.40625 0.59375 0.00215912151156 0.0067037069271386 0.0044314142193493 0.0045445854155786 0 0 0 0 K02510 0.0514285714285714 0.2022792022792023 hpaI, hpcH; 4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 126.0 147.0 139.0 3.0 0.942307692307692 G 21.0 135.0 1.0 1.0 COG3836 2-keto-3-deoxy-L-rhamnonate_aldolase_RhmA HpcH 156.0 0.1346153846153846 0.8653846153846154 0.0138513105049946 0.118315578722237 0.0660834446136158 0.1044642682172423 0 0 0 0 K02511 0.0 0.0056980056980056 hpaX; MFS transporter, ACS family, 4-hydroxyphenylacetate permease 72.0 1.0 0.0 2.0 0.5 EGP 0.0 2.0 2.0 0.5 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 2.0 0.0 1.0 0 0 0 0 K02517 0.0057142857142857 0.50997150997151 lpxL, htrB; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 15.0 267.0 0.0 1.0 1.0 M 7.0 260.0 2.0 0.9812734082397 COG1560 Palmitoleoyl-ACP:_Kdo2-lipid-IV_acyltransferase_(lipid_A_biosynthesis) LpxP 267.0 0.0262172284644194 0.9737827715355806 0.0382202335056597 0.325843337535131 0.1820317855203953 0.2876231040294713 0 0 0 0 K02518 0.0028571428571428 0.9715099715099716 infA; translation initiation factor IF-1 59.0 358.0 0.0 1.0 1.0 J 1.0 357.0 1.0 1.0 COG0361 Translation_initiation_factor_IF-1 InfA 358.0 0.0027932960893854 0.9972067039106144 0.515841722301981 0.897207553869624 0.7065246380858026 0.381365831567643 0 0 0 1 K02519 0.0142857142857142 0.9857549857549858 infB, MTIF2; translation initiation factor IF-2 357.0 356.0 347.0 8.0 0.934383202099738 J 5.0 379.0 15.0 0.919270833333333 COG0532 Translation_initiation_factor_IF-2,_a_GTPase InfB 384.0 0.0130208333333333 0.9869791666666666 0.795802881472379 0.377957040424746 0.5868799609485624 0.417845841047633 1 1 1 1 K02520 0.0028571428571428 0.9829059829059827 infC, MTIF3; translation initiation factor IF-3 103.0 353.0 0.0 1.0 1.0 J 1.0 352.0 1.0 1.0 COG0290 Translation_initiation_factor_IF-3 InfC 353.0 0.0028328611898017 0.9971671388101984 0.0581656011233368 0.475057067905862 0.2666113345145994 0.4168914667825252 0 0 0 0 K02521 0.0 0.0427350427350427 ilvY; LysR family transcriptional regulator, positive regulator for ilvC 274.0 15.0 0.0 1.0 1.0 K 0.0 15.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 15.0 0.0 1.0 0.0094846109483274 0.0212843762891602 0.0153844936187438 0.0117997653408328 0 0 0 0 K02523 0.3 0.5527065527065527 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 108.0 324.0 323.0 2.0 0.996923076923077 H 117.0 209.0 2.0 0.996932515337423 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 326.0 0.3588957055214724 0.6411042944785276 0.828671334248235 0.972249364487308 0.9004603493677715 0.143578030239073 1 1 1 1 K02525 0.0 0.0626780626780626 kdgR; LacI family transcriptional regulator, kdg operon repressor 247.0 23.0 0.0 1.0 1.0 K 0.0 23.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 23.0 0.0 1.0 0.0093989634002201 0.133718899824745 0.0715589316124825 0.1243199364245249 0 0 0 0 K02526 0.0 0.0455840455840455 kdgT; 2-keto-3-deoxygluconate permease 296.0 15.0 12.0 2.0 0.833333333333333 P 0.0 18.0 1.0 1.0 28H7K 18.0 0.0 1.0 0.0886228777007482 0.127592996528946 0.1081079371148471 0.0389701188281978 0 0 0 0 K02527 0.0028571428571428 0.5384615384615384 kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 118.0 212.0 197.0 5.0 0.879668049792531 M 1.0 240.0 6.0 0.83402489626556 COG1519 3-deoxy-D-manno-octulosonic-acid_transferase KdtA 241.0 0.0041493775933609 0.995850622406639 0.024258028570839 0.0371479913709357 0.0307030099708873 0.0128899628000966 0 0 0 0 K02528 0.7885714285714286 0.9772079772079773 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] 59.0 639.0 628.0 4.0 0.962349397590361 J 282.0 382.0 3.0 0.968373493975904 COG0030 16S_rRNA_A1518_and_A1519_N6-dimethyltransferase_RsmA/KsgA/DIM1_(may_also_have_DNA_glycosylase/AP_lyase_activity) RsmA 664.0 0.4246987951807229 0.5753012048192772 0.296587275698143 0.534002063982573 0.415294669840358 0.2374147882844299 0 0 0 0 K02529 0.0 0.0 lacI, galR; LacI family transcriptional regulator 1150.0 1137.0 5.0 0.983746792130026 K 0.0 0.0 9.0 0.958939264328486 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 0.0 0 0 0 0 K02530 0.0 0.0284900284900284 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor 226.0 15.0 0.0 1.0 1.0 K 0.0 15.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 15.0 0.0 1.0 0.0083971049595647 0.419824260290801 0.2141106826251828 0.4114271553312363 0 0 0 0 K02531 0.0 0.0085470085470085 lacT; transcriptional antiterminator 255.0 3.0 0.0 1.0 1.0 K 0.0 3.0 2.0 0.666666666666667 COG3711 Transcriptional_antiterminator BglG 3.0 0.0 1.0 0 0 0 0 K02532 0.0028571428571428 0.0341880341880341 lacY; MFS transporter, OHS family, lactose permease 338.0 12.0 10.0 2.0 0.857142857142857 P 1.0 13.0 3.0 0.714285714285714 COG2223 Nitrate/nitrite_transporter_NarK NarK 14.0 0.0714285714285714 0.9285714285714286 0.976803630557438 0.392020208938572 0.684411919748005 0.5847834216188661 0 0 1 1 K02533 0.1857142857142857 0.3247863247863248 lasT; tRNA/rRNA methyltransferase [EC:2.1.1.-] 135.0 188.0 0.0 1.0 1.0 J 65.0 123.0 1.0 1.0 COG0565 tRNA_C32,U32_(ribose-2'-O)-methylase_TrmJ_or_a_related_methyltransferase TrmJ 188.0 0.3457446808510638 0.6542553191489362 0.736241821109453 0.0238929770557115 0.3800673990825822 0.7123488440537415 0 1 0 1 K02535 0.0 0.4814814814814814 lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 162.0 168.0 161.0 4.0 0.943820224719101 M 0.0 173.0 3.0 0.842696629213483 COG0774 UDP-3-O-acyl-N-acetylglucosamine_deacetylase LpxC 173.0 0.0 1.0 0.359836539208642 0.0508585887030558 0.2053475639558489 0.3089779505055862 0 0 0 0 K02536 0.0228571428571428 0.5726495726495726 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 191.0 209.0 182.0 5.0 0.860082304526749 M 9.0 234.0 4.0 0.97119341563786 COG1044 UDP-3-O-[3-hydroxymyristoyl]_glucosamine_N-acyltransferase LpxD 243.0 0.037037037037037 0.9629629629629628 0.0453967389951872 0.0465586886868388 0.045977713841013 0.0011619496916515 0 0 0 0 K02538 0.0 0.0 manR; mannose operon transcriptional activator 9.0 1.0 3.0 0.391304347826087 G 0.0 0.0 3.0 0.521739130434783 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 0.0 0 0 0 0 K02542 0.0028571428571428 0.0 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3] path:map03030,path:map04110,path:map04111,path:map04113 DNA replication,Cell cycle,Cell cycle - yeast,Meiosis - yeast 174.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG1241 DNA_replicative_helicase_MCM_subunit_Mcm2,_Cdc46/Mcm_family Mcm2 1.0 1.0 0.0 0 0 0 0 K02545 0.0 0.017094017094017 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 642.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 6.0 0.0 1.0 0.0075715086074943 0.0216842497156074 0.0146278791615508 0.0141127411081131 0 0 0 0 K02546 0.0 0.0028490028490028 mecI; BlaI family transcriptional regulator, methicillin resistance regulatory protein path:map01501 beta-Lactam resistance 127.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG3682 Transcriptional_regulator,_CopY/TcrY_family CopY 1.0 0.0 1.0 0 0 0 0 K02547 0.0 0.0028490028490028 mecR1; methicillin resistance protein path:map01501 beta-Lactam resistance 69.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K02548 0.3742857142857143 0.4131054131054131 menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 106.0 334.0 323.0 3.0 0.946175637393768 H 177.0 176.0 2.0 0.920679886685553 COG1575 1,4-dihydroxy-2-naphthoate_polyprenyltransferase MenA 353.0 0.5014164305949008 0.4985835694050991 0.228895517000333 0.817555761947028 0.5232256394736805 0.5886602449466949 0 0 0 0 K02549 0.0885714285714285 0.2849002849002849 menC; o-succinylbenzoate synthase [EC:4.2.1.113] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 109.0 89.0 23.0 3.0 0.5 M 32.0 146.0 4.0 0.792134831460674 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 178.0 0.1797752808988764 0.8202247191011236 0.0182366414348203 0.56756293736635 0.2928997894005851 0.5493262959315297 0 0 0 0 K02550 0.0057142857142857 0.0199430199430199 glcA; glycolate permease 501.0 12.0 11.0 2.0 0.923076923076923 C 3.0 10.0 1.0 1.0 COG1620 L-lactate_permease LldP 13.0 0.2307692307692307 0.7692307692307693 0.0215674425888104 0.042142969808657 0.0318552061987337 0.0205755272198466 0 0 0 0 K02551 0.1171428571428571 0.2962962962962963 menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 264.0 145.0 142.0 3.0 0.966666666666667 H 41.0 109.0 3.0 0.96 COG1165 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate_synthase MenD 150.0 0.2733333333333333 0.7266666666666667 0.0031105010884305 0.241775548495869 0.1224430247921497 0.2386650474074385 0 0 0 0 K02552 0.1228571428571428 0.2962962962962963 menF; menaquinone-specific isochorismate synthase [EC:5.4.4.2] path:map00130,path:map01053,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Biosynthesis of siderophore group nonribosomal peptides,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 196.0 108.0 58.0 3.0 0.679245283018868 HQ 43.0 116.0 2.0 0.993710691823899 COG1169 Isochorismate_synthase_EntC MenF 159.0 0.270440251572327 0.7295597484276729 0.0067386138726674 0.164709988499032 0.0857243011858497 0.1579713746263646 0 0 0 0 K02553 0.0028571428571428 0.1424501424501424 rraA, menG; regulator of ribonuclease activity A 131.0 57.0 0.0 1.0 1.0 H 1.0 56.0 1.0 1.0 COG0684 RNA_degradosome_component_RraA_(regulator_of_RNase_E_activity) RraA 57.0 0.0175438596491228 0.9824561403508772 0.0096345601513257 0.0374613422406485 0.0235479511959871 0.0278267820893228 0 0 0 0 K02554 0.0314285714285714 0.1225071225071225 mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80] path:map00360,path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 171.0 58.0 0.0 1.0 1.0 Q 13.0 56.0 2.0 0.811594202898551 COG3971 2-keto-4-pentenoate_hydratase MhpD 69.0 0.1884057971014492 0.8115942028985508 0.0007510167031697 0.0274445659343211 0.0140977913187454 0.0266935492311514 0 0 0 0 K02556 0.0 0.4301994301994302 motA; chemotaxis protein MotA path:map02020,path:map02030,path:map02040 Two-component system,Bacterial chemotaxis,Flagellar assembly 158.0 199.0 178.0 2.0 0.904545454545454 N 0.0 220.0 3.0 0.981818181818182 COG1291 Flagellar_motor_component_MotA MotA 220.0 0.0 1.0 0.934209036296145 0.183518908368862 0.5588639723325035 0.7506901279272831 0 0 1 1 K02557 0.0 0.5470085470085471 motB; chemotaxis protein MotB path:map02030,path:map02040 Bacterial chemotaxis,Flagellar assembly 22.0 324.0 312.0 5.0 0.939130434782609 N 0.0 345.0 8.0 0.92463768115942 COG1360 Flagellar_motor_protein_MotB MotB 345.0 0.0 1.0 0.0139719429154172 0.0630272539008649 0.038499598408141 0.0490553109854477 0 0 0 0 K02558 0.0 0.2421652421652421 mpl; UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase [EC:6.3.2.45] 291.0 85.0 0.0 1.0 1.0 M 0.0 85.0 1.0 1.0 COG0773 UDP-N-acetylmuramate-alanine_ligase_MurC_and_related_ligases,_MurC/Mpl_family MurC 85.0 0.0 1.0 0.212083283904904 0.871942276298561 0.5420127801017325 0.6598589923936571 0 0 0 0 K02560 0.0028571428571428 0.0569800569800569 lpxM, msbB; lauroyl-Kdo2-lipid IVA myristoyltransferase [EC:2.3.1.243] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 149.0 8.0 1.0 3.0 0.363636363636364 M 1.0 21.0 2.0 0.636363636363636 COG4660 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfE_subunit RnfE 22.0 0.0454545454545454 0.9545454545454546 0.966074598449968 0.375002050356408 0.670538324403188 0.59107254809356 0 0 1 1 K02562 0.0 0.0056980056980056 mtlR; mannitol operon repressor 181.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG3722 DNA-binding_transcriptional_regulator,_MltR_family MtlR 2.0 0.0 1.0 0 0 0 0 K02563 0.0714285714285714 0.9658119658119658 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] path:map00550,path:map01100,path:map01502,path:map04112 Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance,Cell cycle - Caulobacter 97.0 377.0 343.0 3.0 0.912832929782082 M 28.0 385.0 4.0 0.893462469733656 COG0707 UDP-N-acetylglucosamine:LPS_N-acetylglucosamine_transferase MurG 413.0 0.0677966101694915 0.9322033898305084 0.0829191119124472 0.364283086292115 0.2236010991022811 0.2813639743796677 0 0 0 0 K02564 0.0285714285714285 0.3675213675213675 nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 116.0 186.0 184.0 3.0 0.984126984126984 G 10.0 179.0 2.0 0.989417989417989 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate_isomerase/deaminase NagB 189.0 0.0529100529100529 0.9470899470899472 0.0073642872072643 0.016397959782731 0.0118811234949976 0.0090336725754667 0 0 0 0 K02565 0.0028571428571428 0.0398860398860398 nagC; N-acetylglucosamine repressor 65.0 12.0 7.0 3.0 0.666666666666667 K 1.0 17.0 4.0 0.444444444444444 COG1321 Mn-dependent_transcriptional_regulator_MntR,_DtxR_family MntR 18.0 0.0555555555555555 0.9444444444444444 0.0183612453102547 0.157461329064315 0.0879112871872848 0.1391000837540603 0 0 0 0 K02566 0.1428571428571428 0.2222222222222222 nagD; 5'-nucleotidase [EC:3.1.3.5] path:map00230,path:map00240,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 176.0 144.0 0.0 1.0 1.0 G 52.0 92.0 1.0 1.0 COG0647 Ribonucleotide_monophosphatase_NagD,_HAD_superfamily NagD 144.0 0.3611111111111111 0.6388888888888888 0.873307596744412 0.993245794785265 0.9332766957648384 0.1199381980408529 1 1 1 1 K02567 0.0028571428571428 0.131054131054131 napA; nitrate reductase (cytochrome) [EC:1.9.6.1] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 621.0 54.0 0.0 1.0 1.0 C 1.0 53.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 54.0 0.0185185185185185 0.9814814814814816 0.03758304030237 0.0801325776941404 0.0588578089982552 0.0425495373917703 0 0 0 0 K02568 0.0 0.0512820512820512 napB; nitrate reductase (cytochrome), electron transfer subunit path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 110.0 18.0 0.0 1.0 1.0 C 0.0 18.0 2.0 0.944444444444444 COG3043 Nitrate_reductase_cytochrome_c-type_subunit_NapB NapB 18.0 0.0 1.0 0.0442736733954299 0.090300480525644 0.0672870769605369 0.0460268071302141 0 0 0 0 K02569 0.0057142857142857 0.0797720797720797 napC; cytochrome c-type protein NapC 90.0 35.0 0.0 1.0 1.0 C 2.0 33.0 1.0 1.0 COG3005 Tetraheme_cytochrome_c_subunit_NapC_of_nitrate_or_TMAO_reductase NapC 35.0 0.0571428571428571 0.9428571428571428 0.009366809630269 0.0310289209960571 0.020197865313163 0.0216621113657881 0 0 0 0 K02570 0.0 0.0512820512820512 napD; periplasmic nitrate reductase NapD 65.0 18.0 0.0 1.0 1.0 P 0.0 18.0 1.0 1.0 COG3062 Cytoplasmic_chaperone_NapD_for_the_signal_peptide_of_periplasmic_nitrate_reductase_NapAB NapD 18.0 0.0 1.0 0.0484184545632215 0.113931604062023 0.0811750293126222 0.0655131494988015 0 0 0 0 K02571 0.0 0.0085470085470085 napE; periplasmic nitrate reductase NapE 46.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG4459 Periplasmic_nitrate_reductase_system,_NapE_component NapE 3.0 0.0 1.0 0 0 0 0 K02572 0.0057142857142857 0.0769230769230769 napF; ferredoxin-type protein NapF 26.0 32.0 0.0 1.0 1.0 C 2.0 29.0 10.0 0.3125 COG1145 Ferredoxin NapF 31.0 0.064516129032258 0.935483870967742 0.760627367250502 0.200208728777268 0.480418048013885 0.5604186384732339 0 0 1 1 K02573 0.0171428571428571 0.1424501424501424 napG; ferredoxin-type protein NapG 28.0 82.0 0.0 1.0 1.0 C 7.0 76.0 15.0 0.349397590361446 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 83.0 0.0843373493975903 0.9156626506024096 0.0510804499350593 0.0605315327862728 0.055805991360666 0.0094510828512135 0 0 0 0 K02574 0.0714285714285714 0.1054131054131054 napH; ferredoxin-type protein NapH 117.0 71.0 0.0 1.0 1.0 C 26.0 45.0 1.0 1.0 COG0348 Polyferredoxin_NapH NapH 71.0 0.3661971830985915 0.6338028169014085 0.987474811191707 0.992625201903449 0.990050006547578 0.005150390711742 1 1 1 1 K02575 0.1085714285714285 0.2763532763532763 NRT, narK, nrtP, nasA; MFS transporter, NNP family, nitrate/nitrite transporter path:map00910 Nitrogen metabolism 244.0 142.0 84.0 4.0 0.672985781990521 P 65.0 146.0 3.0 0.867298578199052 COG2223 Nitrate/nitrite_transporter_NarK NarK 211.0 0.3080568720379147 0.6919431279620853 0.107635418549936 0.641478048841905 0.3745567336959204 0.533842630291969 0 0 0 0 K02580 0.0 0.0028490028490028 NFKB1; nuclear factor NF-kappa-B p105 subunit path:map01523,path:map04010,path:map04014,path:map04024,path:map04062,path:map04064,path:map04066,path:map04071,path:map04151,path:map04210,path:map04211,path:map04218,path:map04380,path:map04613,path:map04620,path:map04621,path:map04622,path:map04623,path:map04624,path:map04625,path:map04657,path:map04658,path:map04659,path:map04660,path:map04662,path:map04668,path:map04722,path:map04917,path:map04920,path:map04926,path:map04931,path:map04932,path:map04933,path:map04936,path:map05010,path:map05022,path:map05030,path:map05120,path:map05130,path:map05131,path:map05132,path:map05133,path:map05134,path:map05135,path:map05140,path:map05142,path:map05145,path:map05146,path:map05152,path:map05160,path:map05161,path:map05162,path:map05163,path:map05164,path:map05165,path:map05166,path:map05167,path:map05168,path:map05169,path:map05170,path:map05171,path:map05200,path:map05202,path:map05203,path:map05206,path:map05207,path:map05208,path:map05212,path:map05215,path:map05220,path:map05221,path:map05222,path:map05235,path:map05321,path:map05415,path:map05417,path:map05418 Antifolate resistance,MAPK signaling pathway,Ras signaling pathway,cAMP signaling pathway,Chemokine signaling pathway,NF-kappa B signaling pathway,HIF-1 signaling pathway,Sphingolipid signaling pathway,PI3K-Akt signaling pathway,Apoptosis,Longevity regulating pathway,Cellular senescence,Osteoclast differentiation,Neutrophil extracellular trap formation,Toll-like receptor signaling pathway,NOD-like receptor signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Toll and Imd signaling pathway,C-type lectin receptor signaling pathway,IL-17 signaling pathway,Th1 and Th2 cell differentiation,Th17 cell differentiation,T cell receptor signaling pathway,B cell receptor signaling pathway,TNF signaling pathway,Neurotrophin signaling pathway,Prolactin signaling pathway,Adipocytokine signaling pathway,Relaxin signaling pathway,Insulin resistance,Non-alcoholic fatty liver disease,AGE-RAGE signaling pathway in diabetic complications,Alcoholic liver disease,Alzheimer disease,Pathways of neurodegeneration - multiple diseases,Cocaine addiction,Epithelial cell signaling in Helicobacter pylori infection,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Pertussis,Legionellosis,Yersinia infection,Leishmaniasis,Chagas disease,Toxoplasmosis,Amoebiasis,Tuberculosis,Hepatitis C,Hepatitis B,Measles,Human cytomegalovirus infection,Influenza A,Human papillomavirus infection,Human T-cell leukemia virus 1 infection,Kaposi sarcoma-associated herpesvirus infection,Herpes simplex virus 1 infection,Epstein-Barr virus infection,Human immunodeficiency virus 1 infection,Coronavirus disease - COVID-19,Pathways in cancer,Transcriptional misregulation in cancer,Viral carcinogenesis,MicroRNAs in cancer,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species,Pancreatic cancer,Prostate cancer,Chronic myeloid leukemia,Acute myeloid leukemia,Small cell lung cancer,PD-L1 expression and PD-1 checkpoint pathway in cancer,Inflammatory bowel disease,Diabetic cardiomyopathy,Lipid and atherosclerosis,Fluid shear stress and atherosclerosis 303.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K02584 0.0028571428571428 0.2336182336182336 nifA; Nif-specific regulatory protein path:map02020 Two-component system 249.0 78.0 46.0 3.0 0.634146341463415 KT 1.0 122.0 10.0 0.601626016260163 COG3604 FhlA-type_transcriptional_regulator,_contains_GAF,_AAA-type_ATPase,_and_DNA-binding_Fis_domains FhlA 123.0 0.008130081300813 0.991869918699187 0.0072813489677375 0.0558415824694675 0.0315614657186025 0.04856023350173 0 0 0 0 K02585 0.1942857142857142 0.1452991452991453 nifB; nitrogen fixation protein NifB 234.0 77.0 19.0 3.0 0.562043795620438 S 77.0 60.0 2.0 0.992700729927007 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 137.0 0.5620437956204379 0.437956204379562 0.103422003162754 0.0572685247983041 0.080345263980529 0.0461534783644499 0 0 0 0 K02586 0.0542857142857142 0.1424501424501424 nifD; nitrogenase molybdenum-iron protein alpha chain [EC:1.18.6.1] path:map00625,path:map00910,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 383.0 93.0 91.0 2.0 0.978947368421053 C 29.0 66.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 95.0 0.3052631578947368 0.6947368421052632 0.0100318067275722 0.0320850916430561 0.0210584491853141 0.0220532849154838 0 0 0 0 K02587 0.0742857142857142 0.1538461538461538 nifE; nitrogenase molybdenum-cofactor synthesis protein NifE 269.0 100.0 96.0 2.0 0.961538461538462 C 39.0 65.0 2.0 0.980769230769231 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 104.0 0.375 0.625 0.0279553434943802 0.0566603151919706 0.0423078293431754 0.0287049716975904 0 0 0 0 K02588 0.1571428571428571 0.1623931623931624 nifH; nitrogenase iron protein NifH path:map00625,path:map00910,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 241.0 82.0 6.0 4.0 0.488095238095238 D 90.0 78.0 1.0 1.0 COG1348 Nitrogenase_ATPase_subunit_NifH/coenzyme_F430_biosynthesis_subunit_CfbC NifH/CfbC 168.0 0.5357142857142857 0.4642857142857143 0.625853044574449 0.554850412038511 0.5903517283064801 0.0710026325359379 0 1 0 1 K02589 0.0485714285714285 0.0712250712250712 nifHD1, nifI1; nitrogen regulatory protein PII 1 100.0 48.0 44.0 3.0 0.905660377358491 K 21.0 32.0 1.0 1.0 COG0347 Nitrogen_regulatory_protein_PII GlnK 53.0 0.3962264150943396 0.6037735849056604 0.0443412988968533 0.0657956714715134 0.0550684851841833 0.02145437257466 0 0 0 0 K02590 0.0485714285714285 0.0712250712250712 nifHD2, nifI2; nitrogen regulatory protein PII 2 98.0 45.0 38.0 3.0 0.849056603773585 K 21.0 32.0 1.0 1.0 COG0347 Nitrogen_regulatory_protein_PII GlnK 53.0 0.3962264150943396 0.6037735849056604 0.0058072927159622 0.0113535733685775 0.0085804330422698 0.0055462806526153 0 0 0 0 K02591 0.0657142857142857 0.1424501424501424 nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1] path:map00625,path:map00910,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 316.0 102.0 97.0 2.0 0.953271028037383 C 39.0 68.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 107.0 0.3644859813084112 0.6355140186915887 0.0078165074729796 0.0496195253177382 0.0287180163953589 0.0418030178447586 0 0 0 0 K02592 0.0314285714285714 0.1225071225071225 nifN; nitrogenase molybdenum-iron protein NifN 330.0 56.0 54.0 4.0 0.903225806451613 C 11.0 49.0 2.0 0.870967741935484 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 60.0 0.1833333333333333 0.8166666666666667 0.0141098226316845 0.112533548182488 0.0633216854070862 0.0984237255508034 0 0 0 0 K02593 0.0 0.0626780626780626 nifT; nitrogen fixation protein NifT 63.0 22.0 0.0 1.0 1.0 Q 0.0 22.0 1.0 1.0 COG5554 Nitrogen_fixation_protein_NifT NifT 22.0 0.0 1.0 0.0012725998500123 0.0046981854471289 0.0029853926485706 0.0034255855971166 0 0 0 0 K02594 0.0685714285714285 0.188034188034188 nifV; homocitrate synthase NifV [EC:2.3.3.14] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 271.0 90.0 77.0 2.0 0.87378640776699 E 26.0 77.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 103.0 0.2524271844660194 0.7475728155339806 0.915650181895018 0.991449763874608 0.953549972884813 0.07579958197959 1 1 1 1 K02595 0.0 0.0541310541310541 nifW; nitrogenase-stabilizing/protective protein 93.0 18.0 17.0 2.0 0.947368421052632 S 0.0 19.0 1.0 1.0 2E67S 19.0 0.0 1.0 0.0177259103801282 0.0290143334252834 0.0233701219027058 0.0112884230451551 0 0 0 0 K02596 0.0 0.0826210826210826 nifX; nitrogen fixation protein NifX 106.0 32.0 29.0 2.0 0.914285714285714 S 0.0 35.0 2.0 0.914285714285714 COG1433 Predicted_Fe-Mo_cluster-binding_protein,_NifX_family NifX 35.0 0.0 1.0 0.0060250268672413 0.0314389004834421 0.0187319636753417 0.0254138736162008 0 0 0 0 K02597 0.0028571428571428 0.0769230769230769 nifZ; nitrogen fixation protein NifZ 73.0 17.0 5.0 3.0 0.5 Q 1.0 33.0 4.0 0.5 COG5554 Nitrogen_fixation_protein_NifT NifT 34.0 0.0294117647058823 0.9705882352941176 0.0213877147906928 0.0051226616214899 0.0132551882060913 0.0162650531692029 0 0 0 0 K02598 0.0028571428571428 0.0484330484330484 nirC; nitrite transporter 212.0 22.0 0.0 1.0 1.0 P 1.0 21.0 1.0 1.0 COG2116 Formate/nitrite_transporter_FocA,_FNT_family FocA 22.0 0.0454545454545454 0.9545454545454546 0.0097949987237099 0.0347117703039955 0.0222533845138526 0.0249167715802855 0 0 0 0 K02600 0.8571428571428571 0.9857549857549858 nusA; transcription termination/antitermination protein NusA 45.0 681.0 678.0 3.0 0.994160583941606 K 310.0 376.0 5.0 0.976744186046512 COG0195 Transcription_antitermination_factor_NusA,_contains_S1_and_KH_domains NusA 686.0 0.4518950437317784 0.5481049562682215 0.0007429760710713 0.156582115152779 0.0786625456119251 0.1558391390817077 0 0 0 0 K02601 0.9457142857142856 0.9857549857549858 nusG; transcription termination/antitermination protein NusG 67.0 709.0 0.0 1.0 1.0 K 334.0 375.0 1.0 1.0 COG0250 Transcription_termination/antitermination_protein_NusG NusG 709.0 0.4710860366713681 0.5289139633286318 0.0043228573163578 0.0678114205049317 0.0360671389106447 0.0634885631885739 0 0 0 0 K02609 0.0742857142857142 0.1452991452991453 paaA; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA [EC:1.14.13.149] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 262.0 55.0 24.0 2.0 0.63953488372093 S 33.0 53.0 1.0 1.0 COG3396 1,2-phenylacetyl-CoA_epoxidase,_catalytic_subunit YdbO 86.0 0.3837209302325581 0.6162790697674418 0.0907191051645751 0.0369391088795004 0.0638291070220377 0.0537799962850747 0 0 0 0 K02610 0.0885714285714285 0.1339031339031339 paaB; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaB path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 72.0 71.0 55.0 2.0 0.816091954022988 Q 39.0 48.0 3.0 0.551724137931035 COG3460 1,2-phenylacetyl-CoA_epoxidase,_PaaB_subunit PaaB 87.0 0.4482758620689655 0.5517241379310345 0.0010528902927 0.007701247657207 0.0043770689749535 0.006648357364507 0 0 0 0 K02611 0.0628571428571428 0.1339031339031339 paaC; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaC [EC:1.14.13.149] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 214.0 47.0 20.0 2.0 0.635135135135135 S 25.0 49.0 1.0 1.0 COG3396 1,2-phenylacetyl-CoA_epoxidase,_catalytic_subunit YdbO 74.0 0.3378378378378378 0.6621621621621622 0.0092579172233594 0.0921021300477318 0.0506800236355456 0.0828442128243723 0 0 0 0 K02612 0.0257142857142857 0.2022792022792023 paaD; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaD path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 57.0 52.0 18.0 3.0 0.597701149425287 L 9.0 78.0 3.0 0.931034482758621 COG2151 Metal-sulfur_cluster_biosynthetic_enzyme PaaD 87.0 0.1034482758620689 0.896551724137931 0.913132937945753 0.978146363376215 0.945639650660984 0.0650134254304619 1 1 1 1 K02613 0.0114285714285714 0.1481481481481481 paaE; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 244.0 71.0 70.0 2.0 0.986111111111111 C 4.0 68.0 3.0 0.972222222222222 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 72.0 0.0555555555555555 0.9444444444444444 0.0112980053159824 0.0749687559391598 0.0431333806275711 0.0636707506231774 0 0 0 0 K02614 0.2371428571428571 0.245014245014245 paaI; acyl-CoA thioesterase [EC:3.1.2.-] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 62.0 202.0 0.0 1.0 1.0 Q 102.0 100.0 1.0 1.0 COG2050 Acyl-CoA_thioesterase_PaaI,_contains_HGG_motif PaaI 202.0 0.504950495049505 0.495049504950495 0.196314854820023 0.133781689940627 0.165048272380325 0.062533164879396 0 0 0 0 K02615 0.0028571428571428 0.0227920227920227 paaJ; 3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase [EC:2.3.1.223 2.3.1.174] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 384.0 12.0 0.0 1.0 1.0 I 1.0 11.0 1.0 1.0 COG0183 Acetyl-CoA_acetyltransferase PaaJ 12.0 0.0833333333333333 0.9166666666666666 0.0097368644429857 0.0575310090289422 0.0336339367359639 0.0477941445859564 0 0 0 0 K02616 0.0142857142857142 0.1396011396011396 paaX; phenylacetic acid degradation operon negative regulatory protein 60.0 74.0 68.0 2.0 0.925 K 5.0 73.0 2.0 0.925 COG3327 DNA-binding_transcriptional_regulator_PaaX_(phenylacetic_acid_degradation) PaaX 78.0 0.0641025641025641 0.935897435897436 0.0037935965551517 0.88675872435595 0.4452761604555508 0.8829651278007984 0 0 0 0 K02617 0.0457142857142857 0.0883190883190883 paaY; phenylacetic acid degradation protein 134.0 45.0 42.0 3.0 0.882352941176471 S 17.0 34.0 1.0 1.0 COG0663 Carbonic_anhydrase_or_acetyltransferase,_isoleucine_patch_superfamily PaaY 51.0 0.3333333333333333 0.6666666666666666 0.367613338134537 0.826267752804144 0.5969405454693405 0.458654414669607 0 0 0 0 K02618 0.0 0.0854700854700854 paaZ; oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [EC:3.3.2.12 1.2.1.91] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 657.0 30.0 29.0 2.0 0.967741935483871 CI 0.0 31.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 31.0 0.0 1.0 0.0172577463028494 0.0605274993448937 0.0388926228238715 0.0432697530420443 0 0 0 0 K02619 0.0228571428571428 0.4074074074074074 pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 59.0 125.0 95.0 3.0 0.766871165644172 EH 8.0 155.0 1.0 1.0 COG0115 Branched-chain_amino_acid_aminotransferase/4-amino-4-deoxychorismate_lyase IlvE 163.0 0.0490797546012269 0.950920245398773 0.0398523612819768 0.0194529320359548 0.0296526466589658 0.0203994292460219 0 0 0 0 K02621 0.0 0.3532763532763532 parC; topoisomerase IV subunit A [EC:5.6.2.2] 469.0 132.0 0.0 1.0 1.0 L 0.0 132.0 2.0 0.992424242424242 COG0188 DNA_gyrase/topoisomerase_IV,_subunit_A GyrA 132.0 0.0 1.0 0.623110614072925 0.0057433512093928 0.3144269826411589 0.6173672628635322 0 0 0 1 K02622 0.0 0.3789173789173789 parE; topoisomerase IV subunit B [EC:5.6.2.2] 468.0 141.0 0.0 1.0 1.0 L 0.0 141.0 1.0 1.0 COG0187 DNA_gyrase/topoisomerase_IV,_subunit_B GyrB 141.0 0.0 1.0 0.0047233901190939 0.0110403357072573 0.0078818629131756 0.0063169455881634 0 0 0 0 K02623 0.0 0.0398860398860398 pcaQ; LysR family transcriptional regulator, pca operon transcriptional activator 290.0 16.0 0.0 1.0 1.0 K 0.0 16.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 16.0 0.0 1.0 0.0160208072355807 0.0348535255153237 0.0254371663754521 0.0188327182797429 0 0 0 0 K02624 0.0 0.0997150997150997 pcaR; IclR family transcriptional regulator, pca regulon regulatory protein 203.0 51.0 0.0 1.0 1.0 K 0.0 51.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 51.0 0.0 1.0 0.0065867126941747 0.0566205973957547 0.0316036550449647 0.05003388470158 0 0 0 0 K02625 0.0 0.0113960113960113 pcaT; MFS transporter, MHS family, dicarboxylic acid transporter PcaT 164.0 4.0 0.0 1.0 1.0 EGP 0.0 4.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 4.0 0.0 1.0 0 0 0 0 K02626 0.4885714285714285 0.131054131054131 pdaD; arginine decarboxylase [EC:4.1.1.19] path:map00330,path:map01100,path:map01110 Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 106.0 146.0 74.0 3.0 0.629310344827586 E 179.0 53.0 1.0 1.0 COG1945 Pyruvoyl-dependent_arginine_decarboxylase PdaD 232.0 0.771551724137931 0.2284482758620689 0.403719023919836 0.188682426095854 0.296200725007845 0.215036597823982 0 0 0 0 K02628 0.0 0.0056980056980056 pecA; phycoerythrocyanin alpha chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 162.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 28I0N 2.0 0.0 1.0 0 0 0 0 K02629 0.0 0.0056980056980056 pecB; phycoerythrocyanin beta chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 172.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 28I0N 2.0 0.0 1.0 0 0 0 0 K02630 0.0 0.0142450142450142 pecC; phycoerythrocyanin-associated rod linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 137.0 6.0 0.0 1.0 1.0 H 0.0 6.0 1.0 1.0 COG0237 Dephospho-CoA_kinase CoaE 6.0 0.0 1.0 0.0493825807787047 0.111412142544784 0.0803973616617443 0.0620295617660793 0 0 0 0 K02631 0.0 0.0199430199430199 pecE; phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase subunit PecE [EC:4.4.1.31] path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 243.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG1413 HEAT_repeat HEAT 8.0 0.0 1.0 0.0066964113868191 0.0003744723627337 0.0035354418747764 0.0063219390240854 0 0 0 0 K02632 0.0 0.0085470085470085 pecF; phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase subunit PecF [EC:4.4.1.31] path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 110.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1413 HEAT_repeat HEAT 3.0 0.0 1.0 0 0 0 0 K02634 0.0 0.0455840455840455 petA; apocytochrome f path:map00195,path:map01100 Photosynthesis,Metabolic pathways 208.0 18.0 17.0 2.0 0.947368421052632 C 0.0 19.0 3.0 0.736842105263158 COG3258 Thiosulfate_dehydrogenase_TsdA,_contains_C-terminal_cytochrome_c_domain TsdA 19.0 0.0 1.0 1.31058993263495e-12 3.48133350109979e-12 2.39596171686737e-12 2.1707435684648403e-12 0 0 0 0 K02635 0.0085714285714285 0.0883190883190883 petB; cytochrome b6 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 186.0 42.0 0.0 1.0 1.0 C 3.0 39.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 42.0 0.0714285714285714 0.9285714285714286 0.0184132830520313 0.0436791218728434 0.0310462024624373 0.0252658388208121 0 0 0 0 K02636 0.0114285714285714 0.1794871794871795 petC; cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6] path:map00195,path:map01100 Photosynthesis,Metabolic pathways 60.0 102.0 0.0 1.0 1.0 C 4.0 98.0 1.0 1.0 COG0723 Rieske_Fe-S_protein QcrA/PetC 102.0 0.0392156862745098 0.9607843137254902 0.013919820117778 0.0552702128522683 0.0345950164850231 0.0413503927344902 0 0 0 0 K02637 0.0028571428571428 0.0712250712250712 petD; cytochrome b6-f complex subunit 4 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 143.0 28.0 25.0 2.0 0.903225806451613 C 2.0 29.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 31.0 0.064516129032258 0.935483870967742 0.0083279430124954 0.0100129157050666 0.0091704293587809 0.0016849726925712 0 0 0 0 K02638 0.0142857142857142 0.0512820512820512 petE; plastocyanin path:map00195,path:map01100 Photosynthesis,Metabolic pathways 103.0 26.0 0.0 1.0 1.0 C 5.0 21.0 2.0 0.923076923076923 COG3794 Plastocyanin PetE 26.0 0.1923076923076923 0.8076923076923077 0.0104989344036161 0.0267675162426518 0.0186332253231339 0.0162685818390357 0 0 0 0 K02639 0.1114285714285714 0.074074074074074 petF; ferredoxin path:map00195,path:map01100 Photosynthesis,Metabolic pathways 58.0 140.0 136.0 2.0 0.972222222222222 C 66.0 78.0 5.0 0.652777777777778 COG0633 Ferredoxin Fdx 144.0 0.4583333333333333 0.5416666666666666 0.0010719554649305 0.0072331291167628 0.0041525422908466 0.0061611736518323 0 0 0 0 K02640 0.0 0.0256410256410256 petG; cytochrome b6-f complex subunit 5 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 33.0 7.0 5.0 2.0 0.777777777777778 U 0.0 9.0 2.0 0.777777777777778 2EHNG 9.0 0.0 1.0 0.0083280122732763 0.0294369235695423 0.0188824679214093 0.021108911296266 0 0 0 0 K02641 0.0 0.0797720797720797 petH; ferredoxin--NADP+ reductase [EC:1.18.1.2] path:map00195,path:map01100 Photosynthesis,Metabolic pathways 284.0 16.0 4.0 2.0 0.571428571428571 C 0.0 28.0 1.0 1.0 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 28.0 0.0 1.0 0.0252543260146809 0.0304845020502129 0.0278694140324469 0.005230176035532 0 0 0 0 K02642 0.0 0.0028490028490028 petL; cytochrome b6-f complex subunit 6 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 33.0 0.0 1.0 1.0 1.0 2B4E9 1.0 0.0 1.0 0 0 0 0 K02643 0.0 0.0227920227920227 petM; cytochrome b6-f complex subunit 7 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 29.0 5.0 2.0 2.0 0.625 U 0.0 8.0 5.0 0.25 2DRWC 8.0 0.0 1.0 0.001677852819322 4.40671429271527e-05 0.0008609599811245 0.0016337856763948 0 0 0 0 K02647 0.0 0.094017094017094 cdaR; carbohydrate diacid regulator 161.0 31.0 25.0 3.0 0.738095238095238 KT 0.0 42.0 2.0 0.857142857142857 COG3835 Sugar_diacid_utilization_regulator_CdaR CdaR 42.0 0.0 1.0 0.0077628869608556 0.0149246289632495 0.0113437579620525 0.0071617420023939 0 0 0 0 K02650 0.0 0.3988603988603988 pilA; type IV pilus assembly protein PilA path:map02020 Two-component system 12.0 371.0 339.0 2.0 0.920595533498759 NU 0.0 403.0 4.0 0.451612903225806 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 403.0 0.0 1.0 0.469980796613951 0.0660346660117151 0.268007731312833 0.4039461306022359 0 0 0 0 K02651 0.0 0.1282051282051282 flp, pilA; pilus assembly protein Flp/PilA path:map04112 Cell cycle - Caulobacter 35.0 82.0 79.0 2.0 0.964705882352941 U 0.0 85.0 5.0 0.894117647058824 COG3847 Flp_pilus_assembly_protein,_pilin_Flp Flp 85.0 0.0 1.0 0.0064298324401888 0.285136942598234 0.1457833875192114 0.2787071101580452 0 0 0 0 K02652 0.0057142857142857 0.6267806267806267 pilB; type IV pilus assembly protein PilB 214.0 452.0 443.0 3.0 0.978354978354978 NU 3.0 455.0 7.0 0.95021645021645 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 458.0 0.0065502183406113 0.9934497816593888 0.967944707225458 0.957352948165426 0.962648827695442 0.0105917590600319 0 0 1 1 K02653 0.0028571428571428 0.6552706552706553 pilC; type IV pilus assembly protein PilC 158.0 247.0 89.0 2.0 0.609876543209877 U 1.0 404.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 405.0 0.0024691358024691 0.9975308641975308 0.950955599966475 0.871945196554843 0.911450398260659 0.079010403411632 0 0 1 1 K02654 0.0028571428571428 0.7350427350427351 pilD, pppA; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] 29.0 257.0 226.0 3.0 0.886206896551724 NOU 1.0 290.0 4.0 0.989690721649485 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 291.0 0.0034364261168384 0.9965635738831616 0 0 0 0 K02655 0.0 0.1766381766381766 pilE; type IV pilus assembly protein PilE 25.0 86.0 81.0 2.0 0.945054945054945 NU 0.0 91.0 2.0 0.956043956043956 COG4968 Type_IV_pilus_assembly_protein_PilE PilE 91.0 0.0 1.0 0.086642035691909 0.205538794821802 0.1460904152568555 0.118896759129893 0 0 0 0 K02656 0.0 0.1082621082621082 pilF; type IV pilus assembly protein PilF 96.0 39.0 38.0 2.0 0.975 NU 0.0 40.0 3.0 0.925 COG3063 Type_IV_pilus_assembly_protein_PilF/PilW PilF 40.0 0.0 1.0 0.0112700548316352 0.0201748314500553 0.0157224431408452 0.0089047766184201 0 0 0 0 K02657 0.0 0.1025641025641025 pilG; twitching motility two-component system response regulator PilG path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 78.0 34.0 12.0 2.0 0.607142857142857 T 0.0 56.0 5.0 0.678571428571429 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 56.0 0.0 1.0 0.010614263315153 0.0159015265015141 0.0132578949083335 0.0052872631863611 0 0 0 0 K02658 0.0057142857142857 0.1111111111111111 pilH; twitching motility two-component system response regulator PilH path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 95.0 46.0 18.0 2.0 0.621621621621622 T 2.0 72.0 4.0 0.891891891891892 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 74.0 0.027027027027027 0.972972972972973 0.001074703974733 0.12027237171638 0.0606735378455565 0.119197667741647 0 0 0 0 K02659 0.0 0.0854700854700854 pilI; twitching motility protein PilI path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 83.0 43.0 0.0 1.0 1.0 NT 0.0 43.0 1.0 1.0 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 43.0 0.0 1.0 0.0045633593726597 0.0116949356285837 0.0081291475006217 0.007131576255924 0 0 0 0 K02660 0.0028571428571428 0.1994301994301994 pilJ; twitching motility protein PilJ path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 36.0 58.0 10.0 8.0 0.487394957983193 T 1.0 116.0 18.0 0.529411764705882 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 117.0 0.0085470085470085 0.9914529914529916 0.0009141738574282 0.0041238683882389 0.0025190211228335 0.0032096945308107 0 0 0 0 K02661 0.0 0.0113960113960113 pilK; type IV pilus assembly protein PilK path:map02020 Two-component system 258.0 4.0 0.0 1.0 1.0 NT 0.0 4.0 2.0 0.75 COG1352 Methylase_of_chemotaxis_methyl-accepting_proteins CheR 4.0 0.0 1.0 0.0098805879101034 0.0167857897281957 0.0133331888191495 0.0069052018180923 0 0 0 0 K02662 0.0028571428571428 0.5156695156695157 pilM; type IV pilus assembly protein PilM 35.0 238.0 236.0 2.0 0.991666666666667 NU 1.0 239.0 2.0 0.9125 COG4972 Type_IV_pilus_assembly_protein,_ATPase_PilM PilM 240.0 0.0041666666666666 0.9958333333333332 0.0394139463991017 0.692429806054165 0.3659218762266333 0.6530158596550634 0 0 0 0 K02663 0.0 0.3048433048433048 pilN; type IV pilus assembly protein PilN 24.0 122.0 0.0 1.0 1.0 NU 0.0 124.0 4.0 0.887096774193548 COG3166 Type_IV_pilus_assembly_protein_PilN PilN 124.0 0.0 1.0 0.726363755709333 0.477319529803869 0.601841642756601 0.249044225905464 0 0 0 1 K02664 0.0 0.2763532763532763 pilO; type IV pilus assembly protein PilO 41.0 100.0 98.0 4.0 0.961538461538462 NU 0.0 110.0 9.0 0.872727272727273 COG3167 Type_IV_pilus_assembly_protein_PilO PilO 110.0 0.0 1.0 0.0111768098084304 0.0964131299826341 0.0537949698955322 0.0852363201742037 0 0 0 0 K02665 0.0 0.1481481481481481 pilP; type IV pilus assembly protein PilP 44.0 54.0 53.0 2.0 0.981818181818182 NU 0.0 55.0 3.0 0.781818181818182 COG3168 Type_IV_pilus_assembly_protein_PilP PilP 55.0 0.0 1.0 0.0137026000255609 0.0522297870474454 0.0329661935365031 0.0385271870218845 0 0 0 0 K02666 0.0 0.3732193732193732 pilQ; type IV pilus assembly protein PilQ 91.0 158.0 134.0 4.0 0.858695652173913 U 0.0 184.0 6.0 0.836956521739131 COG4796 Type_II_secretory_pathway,_component_HofQ HofQ 184.0 0.0 1.0 0.59676083169902 0.776884079631173 0.6868224556650965 0.180123247932153 0 0 0 1 K02667 0.0028571428571428 0.1538461538461538 pilR, pehR; two-component system, NtrC family, response regulator PilR path:map02020 Two-component system 370.0 57.0 0.0 1.0 1.0 T 1.0 56.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 57.0 0.0175438596491228 0.9824561403508772 0.0030885806793315 0.0290628476847245 0.0160757141820279 0.0259742670053929 0 0 0 0 K02668 0.0028571428571428 0.1452991452991453 pilS, pehS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] path:map02020 Two-component system 200.0 77.0 0.0 1.0 1.0 T 1.0 76.0 9.0 0.376623376623377 COG3852 Signal_transduction_histidine_kinase_NtrB,_nitrogen_specific NtrB 77.0 0.0129870129870129 0.987012987012987 0.0014628107157501 0.0051377518733661 0.0033002812945581 0.003674941157616 0 0 0 0 K02669 0.0057142857142857 0.584045584045584 pilT; twitching motility protein PilT 205.0 368.0 0.0 1.0 1.0 NU 2.0 366.0 3.0 0.989130434782609 COG2805 Type_IV_pilus_assembly_protein_PilT,_pilus_retraction_ATPase PilT 368.0 0.0054347826086956 0.9945652173913044 0.256442010884153 0.932384917058348 0.5944134639712505 0.6759429061741951 0 0 0 0 K02670 0.0 0.0826210826210826 pilU; twitching motility protein PilU 320.0 44.0 0.0 1.0 1.0 NU 0.0 44.0 1.0 1.0 COG5008 Type_IV_pilus_assembly_protein,_ATPase_PilU PilU 44.0 0.0 1.0 0.0123851968756813 0.0771304824064126 0.0447578396410469 0.0647452855307313 0 0 0 0 K02671 0.0 0.1737891737891738 pilV; type IV pilus assembly protein PilV 39.0 73.0 0.0 1.0 1.0 NU 0.0 75.0 2.0 0.973333333333333 COG4967 Type_IV_pilus_assembly_protein_PilV PilV 75.0 0.0 1.0 0.0178734565560475 0.0320661175340459 0.0249697870450467 0.0141926609779984 0 0 0 0 K02672 0.0 0.1452991452991453 pilW; type IV pilus assembly protein PilW 39.0 70.0 65.0 2.0 0.933333333333333 NU 0.0 75.0 4.0 0.76 COG4966 Type_IV_pilus_assembly_protein_PilW PilW 75.0 0.0 1.0 0.027186751709937 0.04037123299144 0.0337789923506885 0.013184481281503 0 0 0 0 K02673 0.0 0.0769230769230769 pilX; type IV pilus assembly protein PilX 46.0 31.0 25.0 2.0 0.837837837837838 NU 0.0 37.0 2.0 0.837837837837838 COG4726 Type_IV_pilus_assembly_protein_PilX PilX 37.0 0.0 1.0 0.308180983713299 0.0195623044318849 0.1638716440725919 0.2886186792814141 0 0 0 0 K02674 0.0028571428571428 0.1566951566951566 pilY1; type IV pilus assembly protein PilY1 158.0 64.0 62.0 5.0 0.888888888888889 NU 1.0 71.0 8.0 0.722222222222222 COG3419 Type_IV_pilus_assembly_protein,_tip-associated_adhesin_PilY1 PilY1 72.0 0.0138888888888888 0.9861111111111112 0.0030839958671479 0.022405243311393 0.0127446195892704 0.0193212474442451 0 0 0 0 K02676 0.0 0.0655270655270655 pilZ; type IV pilus assembly protein PilZ 103.0 26.0 0.0 1.0 1.0 NU 0.0 26.0 1.0 1.0 COG3215 Type_IV_pilus_assembly_protein_PilZ PilZ 26.0 0.0 1.0 0.0097403398786619 0.0147327964136232 0.0122365681461425 0.0049924565349612 0 0 0 0 K02679 0.0 0.0569800569800569 ppdA; prepilin peptidase dependent protein A 61.0 122.0 0.0 1.0 1.0 NU 0.0 122.0 3.0 0.967213114754098 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 122.0 0.0 1.0 0.0031491221557108 0.0003536972310832 0.001751409693397 0.0027954249246276 0 0 0 0 K02680 0.0 0.0284900284900284 ppdB; prepilin peptidase dependent protein B 151.0 10.0 0.0 1.0 1.0 U 0.0 10.0 1.0 1.0 COG4795 Type_II_secretory_pathway,_PulJ/GspJ_component PulJ 10.0 0.0 1.0 0.0892584801238213 0.269143603576939 0.1792010418503801 0.1798851234531177 0 0 0 0 K02681 0.0 0.0484330484330484 ppdC; prepilin peptidase dependent protein C 40.0 17.0 16.0 2.0 0.944444444444444 NU 0.0 18.0 2.0 0.944444444444444 COG4967 Type_IV_pilus_assembly_protein_PilV PilV 18.0 0.0 1.0 0.0778377442913747 0.350485566360216 0.2141616553257953 0.2726478220688413 0 0 0 0 K02682 0.0 0.0541310541310541 ppdD; prepilin peptidase dependent protein D 54.0 21.0 0.0 1.0 1.0 NU 0.0 21.0 1.0 1.0 COG4969 Type_IV_pilus_assembly_protein,_major_pilin_PilA PilA 21.0 0.0 1.0 0.0276755130124816 0.202252531931602 0.1149640224720418 0.1745770189191204 0 0 0 0 K02683 0.7342857142857143 0.0028490028490028 priS, pri1, priA; DNA primase small subunit [EC:2.7.7.102] path:map03030 DNA replication 137.0 264.0 260.0 2.0 0.985074626865672 L 267.0 1.0 1.0 1.0 COG1467 Eukaryotic-type_DNA_primase,_catalytic_(small)_subunit PRI1 268.0 0.996268656716418 0.003731343283582 0.0274030646226069 0.202000007500127 0.1147015360613669 0.1745969428775201 0 0 0 0 K02684 0.0142857142857142 0.0 PRI1; DNA primase small subunit [EC:2.7.7.102] path:map03030 DNA replication 325.0 5.0 0.0 1.0 1.0 L 5.0 0.0 1.0 1.0 COG1467 Eukaryotic-type_DNA_primase,_catalytic_(small)_subunit PRI1 5.0 1.0 0.0 4.10222722250859e-21 7.76442286197254e-13 3.882211451497407e-13 7.764422820950269e-13 0 0 0 0 K02685 0.0171428571428571 0.0 PRI2; DNA primase large subunit path:map03030 DNA replication 409.0 6.0 0.0 1.0 1.0 L 6.0 0.0 1.0 1.0 COG2219 Eukaryotic-type_DNA_primase,_large_subunit PRI2 6.0 1.0 0.0 4.10235029117183e-21 7.76418994238771e-13 3.882094991705607e-13 7.764189901364209e-13 0 0 0 0 K02686 0.0 0.0341880341880341 priB; primosomal replication protein N path:map03440 Homologous recombination 94.0 12.0 0.0 1.0 1.0 L 0.0 12.0 1.0 1.0 COG2965 Primosomal_replication_protein_N PriB 12.0 0.0 1.0 2.63117740855527e-06 0.0001142649024187 5.844803991362764e-05 0.0001116337250101 0 0 0 0 K02687 0.0085714285714285 0.6410256410256411 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] 63.0 255.0 0.0 1.0 1.0 J 3.0 252.0 1.0 1.0 COG2264 Ribosomal_protein_L11_methylase_PrmA PrmA 255.0 0.0117647058823529 0.9882352941176472 0.0947805103876178 0.190659200072161 0.1427198552298894 0.0958786896845432 0 0 0 0 K02688 0.0 0.0398860398860398 prpR; transcriptional regulator, propionate catabolism operon regulatory protein 286.0 36.0 24.0 3.0 0.73469387755102 KT 0.0 49.0 2.0 0.979591836734694 COG3829 RocR-type_transcriptional_regulator,_contains_PAS,_AAA-type_ATPase,_and_DNA-binding_Fis_domains RocR 49.0 0.0 1.0 0.0009883382219183 0.0022616250130121 0.0016249816174651 0.0012732867910937 0 0 0 0 K02689 0.0 0.0398860398860398 psaA; photosystem I P700 chlorophyll a apoprotein A1 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 735.0 14.0 11.0 2.0 0.823529411764706 C 0.0 17.0 1.0 1.0 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 17.0 0.0 1.0 0.0022002586637036 0.0071847001949582 0.0046924794293309 0.0049844415312546 0 0 0 0 K02690 0.0 0.0398860398860398 psaB; photosystem I P700 chlorophyll a apoprotein A2 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 716.0 12.0 6.0 2.0 0.666666666666667 C 0.0 18.0 1.0 1.0 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 18.0 0.0 1.0 0.887953331793167 0.0386706841190559 0.4633120079561115 0.8492826476741111 0 0 1 1 K02691 0.0114285714285714 0.0541310541310541 psaC; photosystem I subunit VII path:map00195,path:map01100 Photosynthesis,Metabolic pathways 77.0 23.0 0.0 1.0 1.0 C 4.0 19.0 3.0 0.695652173913044 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 23.0 0.1739130434782608 0.8260869565217391 0.0068793356271793 0.0112123921515571 0.0090458638893682 0.0043330565243778 0 0 0 0 K02692 0.0 0.0398860398860398 psaD; photosystem I subunit II path:map00195,path:map01100 Photosynthesis,Metabolic pathways 134.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 28NMP 14.0 0.0 1.0 0.0006174914579362 0.0020529949650698 0.0013352432115029 0.0014355035071336 0 0 0 0 K02693 0.0 0.0398860398860398 psaE; photosystem I subunit IV path:map00195,path:map01100 Photosynthesis,Metabolic pathways 58.0 11.0 10.0 4.0 0.785714285714286 S 0.0 14.0 1.0 1.0 2E6G4 14.0 0.0 1.0 0.0006900280585527 0.0016640857160127 0.0011770568872827 0.0009740576574599 0 0 0 0 K02694 0.0 0.0398860398860398 psaF; photosystem I subunit III path:map00195,path:map01100 Photosynthesis,Metabolic pathways 147.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 28NRD 15.0 0.0 1.0 0.0010555863251032 0.0012396638767103 0.0011476251009067 0.0001840775516071 0 0 0 0 K02696 0.0 0.0341880341880341 psaI; photosystem I subunit VIII path:map00195,path:map01100 Photosynthesis,Metabolic pathways 34.0 7.0 3.0 2.0 0.636363636363636 S 0.0 13.0 6.0 0.307692307692308 2EH3J 13.0 0.0 1.0 0.002548191213492 0.0025350777668126 0.0025416344901523 1.3113446679399992e-05 0 0 0 0 K02697 0.0 0.037037037037037 psaJ; photosystem I subunit IX path:map00195,path:map01100 Photosynthesis,Metabolic pathways 41.0 13.0 0.0 1.0 1.0 S 0.0 13.0 3.0 0.769230769230769 2EGDF 13.0 0.0 1.0 0.0050856085148056 0.005862962261965 0.0054742853883853 0.0007773537471594 0 0 0 0 K02698 0.0 0.037037037037037 psaK; photosystem I subunit X path:map00195,path:map01100 Photosynthesis,Metabolic pathways 80.0 20.0 0.0 1.0 1.0 S 0.0 20.0 2.0 0.8 2E3K8 20.0 0.0 1.0 0.0018154259494515 0.0045923051209963 0.0032038655352239 0.0027768791715448 0 0 0 0 K02699 0.0 0.0398860398860398 psaL; photosystem I subunit XI path:map00195,path:map01100 Photosynthesis,Metabolic pathways 144.0 14.0 13.0 2.0 0.933333333333333 S 0.0 15.0 1.0 1.0 28ZUD 15.0 0.0 1.0 0.0036266245345993 0.0071593035989132 0.0053929640667562 0.0035326790643139 0 0 0 0 K02700 0.0 0.0284900284900284 psaM; photosystem I subunit XII path:map00195,path:map01100 Photosynthesis,Metabolic pathways 30.0 7.0 4.0 2.0 0.7 S 0.0 10.0 3.0 0.8 2EI0U 10.0 0.0 1.0 8.87189764043348e-06 0.0039834260487377 0.001996148973189 0.0039745541510972 0 0 0 0 K02702 0.0 0.0142450142450142 psaX; photosystem I 4.8kDa protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 38.0 5.0 0.0 1.0 1.0 S 0.0 5.0 3.0 0.6 2EIIJ 5.0 0.0 1.0 1.30083897495012e-08 2.20435731488334e-06 1.1086828523164207e-06 2.191348925133839e-06 0 0 0 0 K02703 0.0 0.0455840455840455 psbA; photosystem II P680 reaction center D1 protein [EC:1.10.3.9] path:map00195,path:map01100 Photosynthesis,Metabolic pathways 343.0 63.0 0.0 1.0 1.0 C 0.0 63.0 2.0 0.952380952380952 2DBBD 63.0 0.0 1.0 0.0009196628881406 0.0012130304384293 0.0010663466632849 0.0002933675502886 0 0 0 0 K02704 0.0 0.0398860398860398 psbB; photosystem II CP47 chlorophyll apoprotein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 502.0 13.0 12.0 4.0 0.8125 P 0.0 16.0 3.0 0.8125 2DB90 16.0 0.0 1.0 0.0022958650900288 0.0069535004822332 0.004624682786131 0.0046576353922043 0 0 0 0 K02705 0.0 0.0398860398860398 psbC; photosystem II CP43 chlorophyll apoprotein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 325.0 18.0 5.0 3.0 0.5625 S 0.0 32.0 6.0 0.4375 2DB98 32.0 0.0 1.0 0.0009338671156001 0.0030705839624379 0.002002225539019 0.0021367168468378 0 0 0 0 K02706 0.0 0.037037037037037 psbD; photosystem II P680 reaction center D2 protein [EC:1.10.3.9] path:map00195,path:map01100 Photosynthesis,Metabolic pathways 280.0 24.0 0.0 1.0 1.0 C 0.0 24.0 1.0 1.0 2DBDB 24.0 0.0 1.0 0.0017133051825755 0.0001540825959773 0.0009336938892763 0.0015592225865982 0 0 0 0 K02707 0.0 0.0398860398860398 psbE; photosystem II cytochrome b559 subunit alpha path:map00195,path:map01100 Photosynthesis,Metabolic pathways 78.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 2CAD7 14.0 0.0 1.0 1.64633031992468e-06 0.0005742391544309 0.0002879427423754 0.0005725928241109 0 0 0 0 K02708 0.0 0.037037037037037 psbF; photosystem II cytochrome b559 subunit beta path:map00195,path:map01100 Photosynthesis,Metabolic pathways 44.0 13.0 12.0 2.0 0.928571428571429 C 0.0 14.0 2.0 0.928571428571429 2E87T 14.0 0.0 1.0 0.0041278810221403 0.0074125212293858 0.005770201125763 0.0032846402072455 0 0 0 0 K02709 0.0 0.0398860398860398 psbH; photosystem II PsbH protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 60.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 2E88X 14.0 0.0 1.0 0.0013203633775167 0.0055285575800654 0.003424460478791 0.0042081942025487 0 0 0 0 K02710 0.0 0.0341880341880341 psbI; photosystem II PsbI protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 38.0 12.0 0.0 1.0 1.0 U 0.0 12.0 1.0 1.0 2EIT8 12.0 0.0 1.0 0.0106446164743059 0.0169504808843495 0.0137975486793277 0.0063058644100436 0 0 0 0 K02711 0.0 0.0313390313390313 psbJ; photosystem II PsbJ protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 37.0 9.0 7.0 2.0 0.818181818181818 S 0.0 11.0 2.0 0.909090909090909 2EGJI 11.0 0.0 1.0 0.0039338325655714 0.0087189488159632 0.0063263906907673 0.0047851162503918 0 0 0 0 K02712 0.0 0.0398860398860398 psbK; photosystem II PsbK protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 45.0 12.0 10.0 2.0 0.857142857142857 S 0.0 14.0 1.0 1.0 2E3TA 14.0 0.0 1.0 0.0037994633824049 0.0056674602326192 0.004733461807512 0.0018679968502142 0 0 0 0 K02713 0.0 0.0199430199430199 psbL; photosystem II PsbL protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 39.0 7.0 0.0 1.0 1.0 U 0.0 7.0 1.0 1.0 2EGUI 7.0 0.0 1.0 3.93879733396255e-05 2.11502725488337e-05 3.02691229442296e-05 1.82377007907918e-05 0 0 0 0 K02714 0.0 0.0199430199430199 psbM; photosystem II PsbM protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 34.0 5.0 3.0 2.0 0.714285714285714 S 0.0 7.0 1.0 1.0 2EFX3 7.0 0.0 1.0 2.18982878370403e-06 0.0100099559279013 0.0050060728783425 0.0100077660991175 0 0 0 0 K02715 0.0 0.0398860398860398 psbN; PsbN protein 43.0 14.0 0.0 1.0 1.0 S 0.0 14.0 2.0 0.928571428571429 2EFVA 14.0 0.0 1.0 2.76892094554486e-06 0.0011922011272981 0.0005974850241218 0.0011894322063525 0 0 0 0 K02716 0.0 0.0398860398860398 psbO; photosystem II oxygen-evolving enhancer protein 1 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 275.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 28JI2 14.0 0.0 1.0 0.0010105956333554 0.0026522166301291 0.0018314061317422 0.0016416209967737 0 0 0 0 K02717 0.0028571428571428 0.0398860398860398 psbP; photosystem II oxygen-evolving enhancer protein 2 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 170.0 13.0 12.0 3.0 0.866666666666667 S 1.0 14.0 3.0 0.866666666666667 2DC0X 15.0 0.0666666666666666 0.9333333333333332 4.33490334854406e-13 0.0005024440930675 0.0002512220467504 0.000502444092634 0 0 0 0 K02718 0.0 0.0313390313390313 psbT; photosystem II PsbT protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 31.0 5.0 0.0 3.0 0.454545454545455 S 0.0 11.0 3.0 0.818181818181818 2EGXI 11.0 0.0 1.0 0.0027970023416221 0.0055890840766098 0.0041930432091159 0.0027920817349877 0 0 0 0 K02719 0.0 0.0455840455840455 psbU; photosystem II PsbU protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 95.0 18.0 0.0 1.0 1.0 L 0.0 18.0 1.0 1.0 COG1555 DNA_uptake_protein_ComE_or_related_DNA-binding_protein ComEA 18.0 0.0 1.0 0.0112304313775291 0.0224827393976798 0.0168565853876044 0.0112523080201507 0 0 0 0 K02720 0.0 0.0484330484330484 psbV; photosystem II cytochrome c550 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 148.0 22.0 0.0 1.0 1.0 C 0.0 22.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 22.0 0.0 1.0 0.0199201648020718 0.0110648051888073 0.0154924849954395 0.0088553596132644 0 0 0 0 K02722 0.0 0.0284900284900284 psbX; photosystem II PsbX protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 38.0 9.0 8.0 2.0 0.9 U 0.0 10.0 2.0 0.9 2EGTG 10.0 0.0 1.0 0.0093321857874913 0.0067308039456995 0.0080314948665954 0.0026013818417917 0 0 0 0 K02723 0.0 0.0313390313390313 psbY; photosystem II PsbY protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 37.0 11.0 0.0 1.0 1.0 S 0.0 11.0 2.0 0.818181818181818 2EI42 11.0 0.0 1.0 0.0022660085190047 0.0038574780255464 0.0030617432722755 0.0015914695065417 0 0 0 0 K02724 0.0 0.0341880341880341 psbZ; photosystem II PsbZ protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 62.0 11.0 10.0 2.0 0.916666666666667 S 0.0 12.0 2.0 0.916666666666667 2C06H 12.0 0.0 1.0 1.07066051023171e-06 0.0012650906578511 0.0006330806591806 0.0012640199973408 0 0 0 0 K02742 0.0 0.037037037037037 sprT; SprT protein 134.0 9.0 5.0 2.0 0.692307692307692 S 0.0 13.0 1.0 1.0 COG3091 Predicted_Zn-dependent_metalloprotease,_SprT_family SprT 13.0 0.0 1.0 0.0228717651467997 0.0348474203950727 0.0288595927709362 0.011975655248273 0 0 0 0 K02744 0.0 0.0341880341880341 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 120.0 14.0 0.0 1.0 1.0 G 0.0 14.0 1.0 1.0 COG2893 Phosphotransferase_system,_mannose/fructose-specific_component_IIA ManX 14.0 0.0 1.0 0.0449077199535475 0.0637597896893309 0.0543337548214391 0.0188520697357834 0 0 0 0 K02745 0.0 0.0227920227920227 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 154.0 10.0 0.0 1.0 1.0 G 0.0 10.0 1.0 1.0 COG3444 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_component_IIB AgaB 10.0 0.0 1.0 0.0535914029317877 0.112326805064675 0.0829591039982313 0.0587354021328873 0 0 0 0 K02746 0.0 0.037037037037037 agaW; N-acetylgalactosamine PTS system EIIC component path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 246.0 19.0 0.0 1.0 1.0 G 0.0 19.0 1.0 1.0 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 19.0 0.0 1.0 0.0096978179065886 0.0219048002157543 0.0158013090611714 0.0122069823091656 0 0 0 0 K02747 0.0 0.017094017094017 agaE; N-acetylgalactosamine PTS system EIID component path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 247.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 9.0 0.0 1.0 0.0365648913585128 0.0642311137510555 0.0503980025547841 0.0276662223925427 0 0 0 0 K02749 0.0 0.037037037037037 486.0 16.0 0.0 1.0 1.0 G 0.0 16.0 2.0 0.9375 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 16.0 0.0 1.0 0.0122534603829065 0.191221879613238 0.1017376699980722 0.1789684192303315 0 0 0 0 K02750 0.0 0.037037037037037 glvC, malP, aglA; alpha-glucoside PTS system EIICB component [EC:2.7.1.208 2.7.1.-] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 486.0 16.0 0.0 1.0 1.0 G 0.0 16.0 2.0 0.9375 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 16.0 0.0 1.0 0.0110449230602466 0.168696846425028 0.0898708847426373 0.1576519233647814 0 0 0 0 K02752 0.0 0.0113960113960113 85.0 4.0 0.0 1.0 1.0 G 0.0 4.0 2.0 0.75 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 4.0 0.0 1.0 0.0491763397278966 0.148558690975441 0.0988675153516688 0.0993823512475444 0 0 0 0 K02753 0.0 0.0113960113960113 ascF; beta-glucoside (arbutin/salicin/cellobiose) PTS system EIICB component [EC:2.7.1.-] path:map00010,path:map02060 Glycolysis / Gluconeogenesis,Phosphotransferase system (PTS) 85.0 4.0 0.0 1.0 1.0 G 0.0 4.0 2.0 0.75 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 4.0 0.0 1.0 0.04833767303104 0.144723558029072 0.096530615530056 0.096385884998032 0 0 0 0 K02755 0.0 0.0 bglFa; beta-glucoside PTS system EIIA component [EC:2.7.1.-] 80.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.825 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02756 0.0 0.0 75.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.88 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02757 0.0 0.0 bglF, bglP; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] path:map02060 Phosphotransferase system (PTS) 75.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.88 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02759 0.0 0.0911680911680911 celC, chbA; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 92.0 61.0 60.0 2.0 0.983870967741936 G 0.0 62.0 2.0 0.951612903225806 COG1447 Phosphotransferase_system_cellobiose-specific_component_IIA CelC 62.0 0.0 1.0 0.0112000466410429 0.142005204544415 0.0766026255927289 0.1308051579033721 0 0 0 0 K02760 0.0 0.0968660968660968 celA, chbB; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 72.0 59.0 56.0 2.0 0.951612903225806 G 0.0 63.0 3.0 0.936507936507936 COG1440 Phosphotransferase_system_cellobiose-specific_component_IIB CelA 63.0 0.0 1.0 0.0116355046304399 0.455284734921517 0.2334601197759784 0.4436492302910771 0 0 0 0 K02761 0.0 0.1025641025641025 celB, chbC; cellobiose PTS system EIIC component path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 299.0 73.0 66.0 2.0 0.9125 G 0.0 80.0 2.0 0.9625 COG1455 Phosphotransferase_system_cellobiose-specific_component_IIC CelB 80.0 0.0 1.0 0.0138425930968428 0.517578114499071 0.2657103537979569 0.5037355214022282 0 0 0 0 K02763 0.0 0.017094017094017 629.0 6.0 0.0 1.0 1.0 G 0.0 6.0 2.0 0.833333333333333 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 6.0 0.0 1.0 0.016296871870237 0.0592725482106374 0.0377847100404372 0.0429756763404003 0 0 0 0 K02764 0.0 0.017094017094017 629.0 6.0 0.0 1.0 1.0 G 0.0 6.0 2.0 0.833333333333333 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 6.0 0.0 1.0 0.0174079905900594 0.0588859658164192 0.0381469782032393 0.0414779752263598 0 0 0 0 K02765 0.0 0.017094017094017 gamP; D-glucosamine PTS system EIICBA component [EC:2.7.1.-] path:map00520,path:map02060 Amino sugar and nucleotide sugar metabolism,Phosphotransferase system (PTS) 629.0 6.0 0.0 1.0 1.0 G 0.0 6.0 2.0 0.833333333333333 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 6.0 0.0 1.0 0.0173149787942447 0.059262279463848 0.0382886291290463 0.0419473006696033 0 0 0 0 K02768 0.0285714285714285 0.3532763532763532 fruB; fructose PTS system EIIA component [EC:2.7.1.202] path:map00051,path:map01100,path:map01120,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 15.0 190.0 136.0 5.0 0.748031496062992 G 12.0 214.0 13.0 0.433070866141732 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 226.0 0.0530973451327433 0.9469026548672568 0.0527360998031235 0.342332247555185 0.1975341736791542 0.2895961477520615 0 0 0 0 K02769 0.0 0.0 fruAb; fructose PTS system EIIB component [EC:2.7.1.202] path:map00051,path:map01100,path:map01120,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 151.0 117.0 4.0 0.786458333333333 G 0.0 0.0 11.0 0.5 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 0.0 0 0 0 0 K02770 0.0 0.0 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] path:map00051,path:map01100,path:map01120,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 139.0 106.0 4.0 0.776536312849162 G 0.0 0.0 8.0 0.625698324022346 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 0.0 0 0 0 0 K02773 0.0057142857142857 0.0512820512820512 gatA, sgcA; galactitol PTS system EIIA component [EC:2.7.1.200] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 114.0 23.0 12.0 3.0 0.657142857142857 G 3.0 32.0 1.0 1.0 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 35.0 0.0857142857142857 0.9142857142857144 0.013217965627439 0.016816764331019 0.0150173649792289 0.0035987987035799 0 0 0 0 K02774 0.0085714285714285 0.0484330484330484 gatB, sgcB; galactitol PTS system EIIB component [EC:2.7.1.200] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 77.0 34.0 32.0 2.0 0.944444444444444 G 3.0 33.0 1.0 1.0 COG3414 Phosphotransferase_system,_galactitol-specific_IIB_component SgaB 36.0 0.0833333333333333 0.9166666666666666 0.0145022871586776 0.0244637101197725 0.019482998639225 0.0099614229610949 0 0 0 0 K02775 0.0085714285714285 0.0569800569800569 gatC, sgcC; galactitol PTS system EIIC component path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 394.0 38.0 0.0 1.0 1.0 G 3.0 35.0 2.0 0.921052631578947 COG3775 Phosphotransferase_system,_galactitol-specific_IIC_component SgcC 38.0 0.0789473684210526 0.9210526315789472 0.392414750968686 0.0444125529013738 0.2184136519350299 0.3480021980673122 0 0 0 0 K02777 0.0 0.1538461538461538 crr; sugar PTS system EIIA component [EC:2.7.1.-] path:map00010,path:map00500,path:map00520,path:map01100,path:map02026,path:map02060,path:map05111 Glycolysis / Gluconeogenesis,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biofilm formation - Escherichia coli,Phosphotransferase system (PTS),Biofilm formation - Vibrio cholerae 86.0 114.0 0.0 1.0 1.0 G 0.0 93.0 3.0 0.56140350877193 COG2190 Phosphotransferase_system_IIA_component NagE 93.0 0.0 1.0 0.0051906191115886 0.812051978568236 0.4086212988399123 0.8068613594566474 0 0 0 0 K02778 0.0 0.0 ptsGb; glucose PTS system EIIB component [EC:2.7.1.199] 53.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.962264150943396 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02779 0.0 0.0 ptsG; glucose PTS system EIICB or EIICBA component [EC:2.7.1.199] path:map00010,path:map00520,path:map01100,path:map02060,path:map05111 Glycolysis / Gluconeogenesis,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS),Biofilm formation - Vibrio cholerae 53.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.962264150943396 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02781 0.0 0.037037037037037 srlB; glucitol/sorbitol PTS system EIIA component [EC:2.7.1.198] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 110.0 21.0 0.0 1.0 1.0 G 0.0 21.0 1.0 1.0 COG3731 Phosphotransferase_system_sorbitol-specific_IIA_component SrlB 21.0 0.0 1.0 0.0184550218461795 0.302168645382136 0.1603118336141577 0.2837136235359565 0 0 0 0 K02782 0.0 0.0 srlE; glucitol/sorbitol PTS system EIIB component [EC:2.7.1.198] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 28.0 0.0 1.0 1.0 G 0.0 0.0 1.0 1.0 COG3732 Phosphotransferase_system_sorbitol-specific_IIB_component SrlE 0.0 0 0 0 0 K02783 0.0 0.0341880341880341 srlA; glucitol/sorbitol PTS system EIIC component path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 147.0 48.0 0.0 1.0 1.0 G 0.0 42.0 2.0 0.583333333333333 COG3732 Phosphotransferase_system_sorbitol-specific_IIB_component SrlE 42.0 0.0 1.0 0.0106012664879369 0.0252220916961858 0.0179116790920613 0.0146208252082488 0 0 0 0 K02784 0.0 0.0769230769230769 ptsH; phosphocarrier protein HPr path:map02060 Phosphotransferase system (PTS) 79.0 33.0 0.0 1.0 1.0 G 0.0 33.0 1.0 1.0 COG1925 HPr_or_related_phosphotransfer_protein PtsH 33.0 0.0 1.0 0.0135383995332008 0.741557235646331 0.3775478175897659 0.7280188361131302 0 0 0 0 K02786 0.0 0.0284900284900284 lacF; lactose PTS system EIIA component [EC:2.7.1.207] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 101.0 13.0 0.0 1.0 1.0 G 0.0 13.0 1.0 1.0 COG1447 Phosphotransferase_system_cellobiose-specific_component_IIA CelC 13.0 0.0 1.0 0.0535632612260282 0.269755235319799 0.1616592482729136 0.2161919740937708 0 0 0 0 K02787 0.0 0.0227920227920227 535.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG1440 Phosphotransferase_system_cellobiose-specific_component_IIB CelA 9.0 0.0 1.0 0.0452606364961754 0.331620741649827 0.1884406890730012 0.2863601051536516 0 0 0 0 K02788 0.0 0.0227920227920227 lacE; lactose PTS system EIICB component [EC:2.7.1.207] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 535.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG1440 Phosphotransferase_system_cellobiose-specific_component_IIB CelA 9.0 0.0 1.0 0.0449817402612256 0.340882974490138 0.1929323573756818 0.2959012342289124 0 0 0 0 K02790 0.0 0.0398860398860398 470.0 26.0 0.0 1.0 1.0 G 0.0 26.0 2.0 0.961538461538462 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 26.0 0.0 1.0 0.0329269013904273 0.135233912831997 0.0840804071112121 0.1023070114415697 0 0 0 0 K02791 0.0 0.0398860398860398 malX; maltose/glucose PTS system EIICB component [EC:2.7.1.199 2.7.1.208] path:map00010,path:map00500,path:map00520,path:map01100,path:map02060 Glycolysis / Gluconeogenesis,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 470.0 26.0 0.0 1.0 1.0 G 0.0 26.0 2.0 0.961538461538462 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 26.0 0.0 1.0 0.0335764209846186 0.137878685761176 0.0857275533728973 0.1043022647765574 0 0 0 0 K02793 0.0028571428571428 0.2222222222222222 manXa; mannose PTS system EIIA component [EC:2.7.1.191] path:map00051,path:map00520,path:map01100,path:map02060 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 84.0 104.0 103.0 2.0 0.99047619047619 G 2.0 99.0 4.0 0.895238095238095 COG2893 Phosphotransferase_system,_mannose/fructose-specific_component_IIA ManX 101.0 0.0198019801980198 0.9801980198019802 0.0289859803714128 0.0604796492323942 0.0447328148019035 0.0314936688609814 0 0 0 0 K02794 0.0028571428571428 0.1282051282051282 manX; mannose PTS system EIIAB component [EC:2.7.1.191] path:map00051,path:map00520,path:map01100,path:map02060 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 66.0 75.0 72.0 3.0 0.925925925925926 G 1.0 78.0 3.0 0.592592592592593 COG3444 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_component_IIB AgaB 79.0 0.0126582278481012 0.9873417721518988 0.165543628493045 0.44640232518932 0.3059729768411825 0.280858696696275 0 0 0 0 K02795 0.0 0.1054131054131054 manY; mannose PTS system EIIC component path:map00051,path:map00520,path:map01100,path:map02060 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 128.0 55.0 52.0 3.0 0.916666666666667 G 0.0 63.0 5.0 0.777777777777778 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 63.0 0.0 1.0 0.0520566439112163 0.0217439410828993 0.0369002924970578 0.030312702828317 0 0 0 0 K02796 0.0028571428571428 0.1168091168091168 manZ; mannose PTS system EIID component path:map00051,path:map00520,path:map01100,path:map02060 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 199.0 61.0 60.0 2.0 0.983870967741936 G 1.0 61.0 3.0 0.903225806451613 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 62.0 0.0161290322580645 0.9838709677419356 0.0080206486850715 0.0494668807799164 0.0287437647324939 0.0414462320948449 0 0 0 0 K02798 0.0 0.0 cmtB; mannitol PTS system EIIA component [EC:2.7.1.197] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 54.0 52.0 2.0 0.964285714285714 G 0.0 0.0 3.0 0.5 COG2213 Phosphotransferase_system,_mannitol-specific_IIBC_component MtlA 0.0 0 0 0 0 K02799 0.0 0.0854700854700854 368.0 45.0 0.0 1.0 1.0 G 0.0 45.0 2.0 0.955555555555556 COG2213 Phosphotransferase_system,_mannitol-specific_IIBC_component MtlA 45.0 0.0 1.0 0.0236076888811741 0.119432822314075 0.0715202555976245 0.0958251334329008 0 0 0 0 K02800 0.0 0.0854700854700854 mtlA, cmtA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 431.0 43.0 0.0 1.0 1.0 G 0.0 40.0 2.0 0.953488372093023 COG2213 Phosphotransferase_system,_mannitol-specific_IIBC_component MtlA 40.0 0.0 1.0 0.0242553947326627 0.152463125926126 0.0883592603293943 0.1282077311934633 0 0 0 0 K02802 0.0 0.0 38.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.552631578947369 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02803 0.0 0.0 nagEb; N-acetylglucosamine PTS system EIIB component [EC:2.7.1.193] 84.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.761904761904762 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02804 0.0 0.150997150997151 nagE; N-acetylglucosamine PTS system EIICBA or EIICB component [EC:2.7.1.193] path:map00520,path:map02060 Amino sugar and nucleotide sugar metabolism,Phosphotransferase system (PTS) 138.0 81.0 0.0 1.0 1.0 G 0.0 74.0 4.0 0.901234567901235 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 74.0 0.0 1.0 0.0038617825104713 0.408574441987325 0.2062181122488981 0.4047126594768537 0 0 0 0 K02805 0.02 0.1111111111111111 wecE, rffA; dTDP-4-amino-4,6-dideoxygalactose transaminase [EC:2.6.1.59] path:map00541,path:map01100,path:map01250 O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 303.0 46.0 42.0 3.0 0.901960784313726 E 7.0 44.0 2.0 0.980392156862745 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 51.0 0.1372549019607843 0.8627450980392157 0.125098090920765 0.430127666825128 0.2776128788729465 0.3050295759043629 0 0 0 0 K02806 0.0 0.3789173789173789 ptsN; nitrogen PTS system EIIA component [EC:2.7.1.-] path:map02060 Phosphotransferase system (PTS) 17.0 154.0 114.0 6.0 0.69683257918552 G 0.0 210.0 8.0 0.819004524886878 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 210.0 0.0 1.0 0.0079825721314997 0.0742159432463188 0.0410992576889092 0.0662333711148191 0 0 0 0 K02808 0.0 0.0626780626780626 169.0 29.0 0.0 1.0 1.0 G 0.0 27.0 3.0 0.862068965517241 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 27.0 0.0 1.0 0.0112066127366168 0.0157264417968288 0.0134665272667228 0.004519829060212 0 0 0 0 K02809 0.0 0.0 85.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.952941176470588 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02810 0.0 0.0 scrA, sacP, sacX, ptsS; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 85.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.952941176470588 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02813 0.0 0.0028490028490028 sorB; sorbose PTS system EIIB component [EC:2.7.1.206] path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 163.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG3444 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_component_IIB AgaB 1.0 0.0 1.0 0 0 0 0 K02814 0.0 0.0113960113960113 sorA, sorC; sorbose PTS system EIIC component path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 254.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 4.0 0.0 1.0 0.129210889285891 0.24207137579521 0.1856411325405504 0.1128604865093189 0 0 0 0 K02815 0.0 0.0142450142450142 sorM, sorD; sorbose PTS system EIID component path:map00051,path:map01100,path:map02060 Fructose and mannose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 258.0 5.0 0.0 1.0 1.0 G 0.0 5.0 2.0 0.8 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 5.0 0.0 1.0 0.0697460371702231 0.479697407899708 0.2747217225349655 0.4099513707294849 0 0 0 0 K02817 0.0 0.0 11.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.909090909090909 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02818 0.0 0.0 34.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.970588235294118 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02819 0.0 0.0 treB, treP; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 34.0 0.0 1.0 1.0 G 0.0 0.0 2.0 0.970588235294118 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K02821 0.0 0.1253561253561253 ulaC, sgaA; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] path:map00053,path:map01100,path:map01120,path:map02060 Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 56.0 45.0 40.0 4.0 0.803571428571429 G 0.0 56.0 3.0 0.660714285714286 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 56.0 0.0 1.0 0.256246429413889 0.193206917726302 0.2247266735700955 0.0630395116875869 0 0 0 0 K02822 0.0 0.0911680911680911 ulaB, sgaB; ascorbate PTS system EIIB component [EC:2.7.1.194] path:map00053,path:map01100,path:map01120,path:map02060 Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 73.0 35.0 29.0 3.0 0.795454545454545 G 0.0 44.0 2.0 0.886363636363636 COG3414 Phosphotransferase_system,_galactitol-specific_IIB_component SgaB 44.0 0.0 1.0 0.284311586500907 0.208308058805459 0.246309822653183 0.0760035276954479 0 0 0 0 K02823 0.5085714285714286 0.4985754985754986 pyrDII; dihydroorotate dehydrogenase electron transfer subunit path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 27.0 325.0 224.0 4.0 0.704989154013015 C 222.0 239.0 3.0 0.815618221258134 COG0543 NAD(P)H-flavin_reductase Mcr1 461.0 0.4815618221258134 0.5184381778741866 0.375889658045754 0.103516835952315 0.2397032469990345 0.272372822093439 0 0 0 0 K02824 0.0314285714285714 0.3133903133903133 uraA, pyrP; uracil permease 327.0 124.0 0.0 1.0 1.0 F 11.0 113.0 1.0 1.0 COG2233 Xanthine/uracil_permease UraA 124.0 0.0887096774193548 0.9112903225806452 0.0186408140085067 0.797536791708052 0.4080888028582793 0.7788959776995453 0 0 0 0 K02825 0.0 0.5584045584045584 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 124.0 214.0 0.0 1.0 1.0 F 0.0 214.0 1.0 1.0 COG2065 Pyrimidine_operon_attenuation_protein_PyrR/uracil_phosphoribosyltransferase PyrR 214.0 0.0 1.0 0.594553376183251 0.558469892112279 0.576511634147765 0.0360834840709719 0 0 0 1 K02826 0.0514285714285714 0.0313390313390313 qoxA; cytochrome aa3-600 menaquinol oxidase subunit II [EC:7.1.1.5] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 70.0 38.0 0.0 1.0 1.0 C 27.0 11.0 1.0 1.0 COG1622 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_2 CyoA 38.0 0.7105263157894737 0.2894736842105263 0.0829787277049898 0.0495327312055652 0.0662557294552775 0.0334459964994246 0 0 0 0 K02827 0.0542857142857142 0.0284900284900284 qoxB; cytochrome aa3-600 menaquinol oxidase subunit I [EC:7.1.1.5] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 436.0 40.0 0.0 1.0 1.0 C 30.0 10.0 1.0 1.0 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 40.0 0.75 0.25 0.0630087963957857 0.0421290626191802 0.0525689295074829 0.0208797337766055 0 0 0 0 K02828 0.0314285714285714 0.0199430199430199 qoxC; cytochrome aa3-600 menaquinol oxidase subunit III [EC:7.1.1.5] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 178.0 18.0 0.0 1.0 1.0 C 11.0 7.0 2.0 0.611111111111111 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 18.0 0.6111111111111112 0.3888888888888889 0.0314981848788109 0.384952651517405 0.2082254181981079 0.3534544666385941 0 0 0 0 K02829 0.0 0.0199430199430199 qoxD; cytochrome aa3-600 menaquinol oxidase subunit IV [EC:7.1.1.5] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 93.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG3125 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_4 CyoD 7.0 0.0 1.0 4.38832019576614e-06 0.0019205727897638 0.0009624805549797 0.001916184469568 0 0 0 0 K02834 0.0 0.9316239316239316 rbfA; ribosome-binding factor A 62.0 330.0 0.0 1.0 1.0 J 0.0 330.0 2.0 0.993939393939394 COG0858 Ribosome-binding_factor_RbfA RbfA 330.0 0.0 1.0 0.0970554280553343 0.0701260366050806 0.0835907323302074 0.0269293914502537 0 0 0 0 K02835 0.0028571428571428 0.9914529914529916 prfA, MTRF1, MRF1; peptide chain release factor 1 268.0 355.0 0.0 1.0 1.0 J 1.0 354.0 2.0 0.997183098591549 COG0216 Protein_chain_release_factor_RF1 PrfA 355.0 0.0028169014084507 0.9971830985915492 0.932778769317362 0.912119096323822 0.922448932820592 0.0206596729935399 0 0 1 1 K02836 0.0028571428571428 0.9829059829059827 prfB; peptide chain release factor 2 233.0 349.0 0.0 1.0 1.0 J 1.0 348.0 2.0 0.988538681948424 COG1186 Protein_chain_release_factor_PrfB PrfB 349.0 0.0028653295128939 0.997134670487106 0.0388884806598153 0.0726727287959177 0.0557806047278665 0.0337842481361023 0 0 0 0 K02837 0.0 0.49002849002849 prfC; peptide chain release factor 3 420.0 177.0 0.0 1.0 1.0 J 0.0 177.0 1.0 1.0 COG4108 Peptide_chain_release_factor_RF-3 PrfC 177.0 0.0 1.0 0.0324795332573972 0.0238903597176003 0.0281849464874987 0.0085891735397969 0 0 0 0 K02838 0.0057142857142857 0.9886039886039886 frr, MRRF, RRF; ribosome recycling factor 168.0 351.0 0.0 1.0 1.0 J 2.0 349.0 1.0 1.0 COG0233 Ribosome_recycling_factor Frr 351.0 0.0056980056980056 0.9943019943019944 0.585311702567096 0.404590645785061 0.4949511741760785 0.1807210567820349 0 0 0 1 K02839 0.0028571428571428 0.037037037037037 prfH; peptide chain release factor 160.0 14.0 0.0 1.0 1.0 J 1.0 13.0 3.0 0.857142857142857 COG1186 Protein_chain_release_factor_PrfB PrfB 14.0 0.0714285714285714 0.9285714285714286 0.172510031679853 0.253925338169334 0.2132176849245934 0.081415306489481 0 0 0 0 K02840 0.0 0.0085470085470085 waaB, rfaB; UDP-D-galactose:(glucosyl)LPS alpha-1,6-D-galactosyltransferase [EC:2.4.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 333.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 3.0 0.0 1.0 0 0 0 0 K02841 0.0085714285714285 0.225071225071225 waaC, rfaC; lipopolysaccharide heptosyltransferase I [EC:2.4.99.23] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 110.0 101.0 99.0 3.0 0.971153846153846 M 3.0 101.0 1.0 1.0 COG0859 ADP-heptose:LPS_heptosyltransferase RfaF 104.0 0.0288461538461538 0.971153846153846 0.0144469356674596 0.282408328700799 0.1484276321841293 0.2679613930333394 0 0 0 0 K02843 0.0628571428571428 0.4188034188034188 waaF, rfaF; lipopolysaccharide heptosyltransferase II [EC:2.4.99.24] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 24.0 320.0 314.0 6.0 0.946745562130178 M 33.0 305.0 2.0 0.964497041420118 COG0859 ADP-heptose:LPS_heptosyltransferase RfaF 338.0 0.0976331360946745 0.9023668639053254 0.0234747568241874 0.414000082733076 0.2187374197786317 0.3905253259088885 0 0 0 0 K02844 0.02 0.1225071225071225 waaG, rfaG; UDP-glucose:(heptosyl)LPS alpha-1,3-glucosyltransferase [EC:2.4.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 114.0 51.0 49.0 2.0 0.962264150943396 M 7.0 46.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 53.0 0.1320754716981132 0.8679245283018868 0.0520689564580945 0.751875495757711 0.4019722261079027 0.6998065392996164 0 0 0 0 K02846 0.0 0.037037037037037 solA; N-methyl-L-tryptophan oxidase [EC:1.5.3.-] 351.0 11.0 9.0 2.0 0.846153846153846 E 0.0 13.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 13.0 0.0 1.0 0.0219363513218549 0.0744249526081588 0.0481806519650068 0.0524886012863039 0 0 0 0 K02847 0.0 0.2051282051282051 waaL, rfaL; O-antigen ligase [EC:2.4.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 77.0 91.0 0.0 1.0 1.0 M 0.0 91.0 4.0 0.879120879120879 COG3307 O-antigen_ligase RfaL 91.0 0.0 1.0 0.89787464636769 0.683483946879031 0.7906792966233605 0.2143906994886589 0 0 1 1 K02848 0.0 0.0227920227920227 waaP, rfaP; lipopolysaccharide core heptose(I) kinase [EC:2.7.1.235] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 247.0 4.0 2.0 3.0 0.5 F 0.0 8.0 2.0 0.75 COG0515 Serine/threonine_protein_kinase SPS1 8.0 0.0 1.0 0.126963462898001 0.305694725837327 0.216329094367664 0.1787312629393259 0 0 0 0 K02849 0.04 0.2022792022792023 waaQ, rfaQ; lipopolysaccharide heptosyltransferase III [EC:2.4.99.25] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 86.0 118.0 115.0 3.0 0.967213114754098 M 19.0 103.0 3.0 0.983606557377049 COG0859 ADP-heptose:LPS_heptosyltransferase RfaF 122.0 0.1557377049180328 0.8442622950819673 0.164345751122681 0.783161294888991 0.473753523005836 0.61881554376631 0 0 0 0 K02850 0.0028571428571428 0.0113960113960113 waaY, rfaY; heptose II phosphotransferase [EC:2.7.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 141.0 6.0 5.0 2.0 0.857142857142857 T 1.0 6.0 2.0 0.857142857142857 COG3642 tRNA_A-37_threonylcarbamoyl_transferase_component_Bud32 Bud32 7.0 0.1428571428571428 0.8571428571428571 0.0067178535225911 0.0146712154327814 0.0106945344776862 0.0079533619101903 0 0 0 0 K02851 0.0 0.6011396011396012 wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] path:map00542,path:map00543,path:map00552,path:map00572,path:map01100 O-Antigen repeat unit biosynthesis,Exopolysaccharide biosynthesis,Teichoic acid biosynthesis,Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 103.0 260.0 256.0 6.0 0.970149253731343 M 1.0 267.0 4.0 0.932835820895522 COG0472 UDP-N-acetylmuramyl_pentapeptide_phosphotransferase/UDP-N-acetylglucosamine-1-phosphate_transferase Rfe 268.0 0.003731343283582 0.996268656716418 0.513694498440339 0.624026656222171 0.568860577331255 0.110332157781832 0 0 0 1 K02852 0.0 0.017094017094017 wecG, rffM; UDP-N-acetyl-D-mannosaminouronate:lipid I N-acetyl-D-mannosaminouronosyltransferase [EC:2.4.1.180] path:map00543 Exopolysaccharide biosynthesis 231.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG1922 UDP-N-acetyl-D-mannosaminuronic_acid_transferase,_WecB/TagA/CpsF_family WecG 6.0 0.0 1.0 9.52868287300165e-05 9.67135895843014e-12 4.764341920068773e-05 9.528681905865756e-05 0 0 0 0 K02853 0.0 0.0113960113960113 wzyE, rffT; enterobacterial common antigen polymerase [EC:2.4.1.-] 417.0 2.0 0.0 2.0 0.5 S 0.0 4.0 1.0 1.0 2DB7H 4.0 0.0 1.0 1.23358439335641e-21 2.5491823274094997e-13 1.274591169872672e-13 2.549182315073657e-13 0 0 0 0 K02854 0.0 0.0284900284900284 rhaR; AraC family transcriptional regulator, L-rhamnose operon transcriptional activator RhaR 196.0 22.0 0.0 1.0 1.0 K 0.0 22.0 3.0 0.772727272727273 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 22.0 0.0 1.0 0.0041076769407684 0.0077324300746016 0.005920053507685 0.0036247531338332 0 0 0 0 K02855 0.0 0.037037037037037 rhaS; AraC family transcriptional regulator, L-rhamnose operon regulatory protein RhaS 146.0 24.0 0.0 1.0 1.0 K 0.0 24.0 4.0 0.5 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 24.0 0.0 1.0 0.003303699961862 0.0063532289071991 0.0048284644345305 0.0030495289453371 0 0 0 0 K02856 0.0 0.0427350427350427 rhaT; L-rhamnose-H+ transport protein 333.0 15.0 14.0 2.0 0.9375 EG 0.0 16.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 16.0 0.0 1.0 0.0961954275866332 0.0243966174244554 0.0602960225055443 0.0717988101621778 0 0 0 0 K02858 0.5057142857142857 0.1481481481481481 ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 163.0 243.0 242.0 2.0 0.995901639344262 H 185.0 57.0 3.0 0.975409836065574 COG0108 3,4-dihydroxy-2-butanone_4-phosphate_synthase RibB 242.0 0.7644628099173554 0.2355371900826446 0.539670420827687 0.215477617904942 0.3775740193663145 0.324192802922745 0 1 0 1 K02859 0.0 0.0284900284900284 ribT; riboflavin biosynthesis RibT protein 116.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 10.0 0.0 1.0 0.0003775500537881 3.48129190762948e-08 0.0001887924333535 0.000377515240869 0 0 0 0 K02860 0.0 0.7863247863247863 rimM; 16S rRNA processing protein RimM 31.0 277.0 0.0 1.0 1.0 J 0.0 277.0 1.0 1.0 COG0806 Ribosomal_30S_subunit_maturation_factor_RimM,_required_for_16S_rRNA_processing RimM 277.0 0.0 1.0 0.169238686290179 0.829072589806177 0.499155638048178 0.659833903515998 0 0 0 0 K02862 0.0 0.0427350427350427 ctaG; putative membrane protein 230.0 17.0 16.0 2.0 0.944444444444444 S 0.0 18.0 1.0 1.0 COG3336 Cytochrome_c_oxidase_assembly_protein_CtaG CtaG 18.0 0.0 1.0 0.0076510960249098 0.134323331747989 0.0709872138864494 0.1266722357230792 0 0 0 0 K02863 0.9371428571428572 0.9373219373219374 RP-L1, MRPL1, rplA; large subunit ribosomal protein L1 path:map03010 Ribosome 137.0 660.0 0.0 1.0 1.0 J 329.0 331.0 1.0 1.0 COG0081 Ribosomal_protein_L1 RplA 660.0 0.4984848484848485 0.5015151515151515 0.897816610024402 0.0726053055913313 0.4852109578078666 0.8252113044330708 1 1 1 1 K02864 0.9228571428571428 0.9772079772079773 RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10 path:map03010 Ribosome 82.0 668.0 0.0 1.0 1.0 J 324.0 344.0 1.0 1.0 COG0244 Ribosomal_protein_L10 RplJ 668.0 0.4850299401197604 0.5149700598802395 0.0754855395859977 0.136237769621856 0.1058616546039268 0.0607522300358582 0 0 0 0 K02866 0.9257142857142856 0.0 RP-L10e, RPL10; large subunit ribosomal protein L10e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 120.0 328.0 0.0 1.0 1.0 J 328.0 0.0 2.0 0.996951219512195 COG0197 Ribosomal_protein_L16/L10AE RplP 328.0 1.0 0.0 0.869363648332535 0.467323758452312 0.6683437033924235 0.402039889880223 0 0 1 1 K02867 0.9142857142857144 0.9914529914529916 RP-L11, MRPL11, rplK; large subunit ribosomal protein L11 path:map03010 Ribosome 113.0 674.0 0.0 1.0 1.0 J 322.0 352.0 1.0 1.0 COG0080 Ribosomal_protein_L11 RplK 674.0 0.4777448071216617 0.5222551928783383 0.156076074191795 0.449959216173074 0.3030176451824345 0.2938831419812789 0 0 0 0 K02869 0.8942857142857142 0.0 RP-L12, rpl12; large subunit ribosomal protein L12 path:map03010 Ribosome 64.0 315.0 0.0 1.0 1.0 J 315.0 0.0 1.0 1.0 COG2058 Ribosomal_protein_L12E/L44/L45/RPP1/RPP2 RPP1A 315.0 1.0 0.0 0.310810661916093 0.357632347319031 0.334221504617562 0.0468216854029379 0 0 0 0 K02871 0.94 0.9943019943019944 RP-L13, MRPL13, rplM; large subunit ribosomal protein L13 path:map03010 Ribosome 60.0 681.0 0.0 1.0 1.0 J 331.0 350.0 1.0 1.0 COG0102 Ribosomal_protein_L13 RplM 681.0 0.4860499265785609 0.5139500734214391 0.307376465080395 0.704713100772832 0.5060447829266135 0.397336635692437 0 0 0 0 K02873 0.1171428571428571 0.0 RP-L13e, RPL13; large subunit ribosomal protein L13e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 57.0 43.0 0.0 1.0 1.0 J 43.0 0.0 2.0 0.953488372093023 COG4352 Ribosomal_protein_L13E RPL13 43.0 1.0 0.0 0.457527798709669 0.914073581784714 0.6858006902471915 0.456545783075045 0 0 0 0 K02874 0.9542857142857144 0.9943019943019944 RP-L14, MRPL14, rplN; large subunit ribosomal protein L14 path:map03010 Ribosome 102.0 683.0 0.0 1.0 1.0 J 334.0 349.0 1.0 1.0 COG0093 Ribosomal_protein_L14 RplN 683.0 0.4890190336749634 0.5109809663250366 0.905150795997229 0.470266857815657 0.6877088269064431 0.434883938181572 1 1 1 1 K02875 0.4428571428571428 0.0 RP-L14e, RPL14; large subunit ribosomal protein L14e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 69.0 155.0 0.0 1.0 1.0 J 155.0 0.0 1.0 1.0 COG2163 Ribosomal_protein_L14E/L6E/L27E RPL14A 155.0 1.0 0.0 0.862420680020244 0.932814675460611 0.8976176777404274 0.070393995440367 0 0 1 1 K02876 0.92 0.9886039886039886 RP-L15, MRPL15, rplO; large subunit ribosomal protein L15 path:map03010 Ribosome 20.0 672.0 0.0 1.0 1.0 J 323.0 348.0 1.0 1.0 COG0200 Ribosomal_protein_L15 RplO 671.0 0.481371087928465 0.518628912071535 0.460498193001323 0.46599982020503 0.4632490066031764 0.005501627203707 0 0 0 0 K02877 0.9342857142857144 0.0 RP-L15e, RPL15; large subunit ribosomal protein L15e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 152.0 328.0 0.0 1.0 1.0 J 328.0 0.0 1.0 1.0 COG1632 Ribosomal_protein_L15E RPL15A 328.0 1.0 0.0 0.952671189794405 0.915234019062558 0.9339526044284816 0.037437170731847 0 0 1 1 K02878 0.0 0.9886039886039886 RP-L16, MRPL16, rplP; large subunit ribosomal protein L16 path:map03010 Ribosome 127.0 350.0 0.0 1.0 1.0 J 0.0 350.0 1.0 1.0 COG0197 Ribosomal_protein_L16/L10AE RplP 350.0 0.0 1.0 0.929431408408176 0.92636442289793 0.9278979156530528 0.0030669855102459 0 0 1 1 K02879 0.0 0.9914529914529916 RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17 path:map03010 Ribosome 67.0 349.0 348.0 2.0 0.997142857142857 J 0.0 350.0 2.0 0.997142857142857 COG0203 Ribosomal_protein_L17 RplQ 350.0 0.0 1.0 0.0234626677631551 0.180235513576724 0.1018490906699395 0.1567728458135688 0 0 0 0 K02880 0.0028571428571428 0.0 RP-L17e, RPL17; large subunit ribosomal protein L17e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 193.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0091 Ribosomal_protein_L22 RplV 1.0 1.0 0.0 0 0 0 0 K02881 0.94 0.9857549857549858 RP-L18, MRPL18, rplR; large subunit ribosomal protein L18 path:map03010 Ribosome 75.0 676.0 0.0 1.0 1.0 J 330.0 346.0 1.0 1.0 COG0256 Ribosomal_protein_L18 RplR 676.0 0.4881656804733728 0.5118343195266272 0.0373311675020673 0.484926818773377 0.2611289931377221 0.4475956512713097 0 0 0 0 K02883 0.9142857142857144 0.0 RP-L18e, RPL18; large subunit ribosomal protein L18e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 105.0 321.0 0.0 1.0 1.0 J 321.0 0.0 1.0 1.0 COG1727 Ribosomal_protein_L18E RPL18A 321.0 1.0 0.0 0.75659244322706 0.0177886865236849 0.3871905648753724 0.7388037567033751 0 0 1 1 K02884 0.0028571428571428 0.9829059829059827 RP-L19, MRPL19, rplS; large subunit ribosomal protein L19 path:map03010 Ribosome 66.0 347.0 346.0 2.0 0.997126436781609 J 1.0 347.0 2.0 0.997126436781609 COG0335 Ribosomal_protein_L19 RplS 348.0 0.0028735632183908 0.9971264367816092 0.0189486545748506 0.371293086521159 0.1951208705480048 0.3523444319463084 0 0 0 0 K02885 0.9285714285714286 0.0 RP-L19e, RPL19; large subunit ribosomal protein L19e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 121.0 326.0 0.0 1.0 1.0 J 326.0 0.0 1.0 1.0 COG2147 Ribosomal_protein_L19E RPL19A 326.0 1.0 0.0 0.974575768126319 0.876666065593965 0.925620916860142 0.0979097025323539 0 0 1 1 K02886 0.9371428571428572 0.9829059829059827 RP-L2, MRPL2, rplB; large subunit ribosomal protein L2 path:map03010 Ribosome 159.0 677.0 0.0 1.0 1.0 J 331.0 346.0 1.0 1.0 COG0090 Ribosomal_protein_L2 RplB 677.0 0.4889217134416543 0.5110782865583456 0.989837013512829 0.836755915092244 0.9132964643025364 0.153081098420585 1 1 1 1 K02887 0.0 0.9829059829059827 RP-L20, MRPL20, rplT; large subunit ribosomal protein L20 path:map03010 Ribosome 106.0 345.0 319.0 2.0 0.929919137466307 J 0.0 371.0 2.0 0.929919137466307 COG0292 Ribosomal_protein_L20 RplT 371.0 0.0 1.0 0.0058280115391775 0.0055750872035895 0.0057015493713835 0.0002529243355879 0 0 0 0 K02888 0.0 0.9743589743589745 RP-L21, MRPL21, rplU; large subunit ribosomal protein L21 path:map03010 Ribosome 83.0 342.0 341.0 2.0 0.997084548104956 J 0.0 343.0 2.0 0.997084548104956 COG0261 Ribosomal_protein_L21 RplU 343.0 0.0 1.0 0.326329186891327 0.47799632665833 0.4021627567748285 0.1516671397670029 0 0 0 0 K02889 0.9514285714285714 0.0 RP-L21e, RPL21; large subunit ribosomal protein L21e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 86.0 334.0 0.0 1.0 1.0 J 334.0 0.0 1.0 1.0 COG2139 Ribosomal_protein_L21E RPL21A 334.0 1.0 0.0 0.835504111117654 0.823412791104201 0.8294584511109275 0.012091320013453 0 0 1 1 K02890 0.9314285714285714 0.9943019943019944 RP-L22, MRPL22, rplV; large subunit ribosomal protein L22 path:map03010 Ribosome 45.0 678.0 677.0 2.0 0.998527245949926 J 328.0 351.0 2.0 0.998527245949926 COG0091 Ribosomal_protein_L22 RplV 679.0 0.4830633284241531 0.5169366715758469 0.0372877393914991 0.0162516667035829 0.0267697030475409 0.0210360726879161 0 0 0 0 K02892 0.9114285714285716 0.9857549857549858 RP-L23, MRPL23, rplW; large subunit ribosomal protein L23 path:map03010 Ribosome 35.0 667.0 0.0 1.0 1.0 J 320.0 347.0 1.0 1.0 COG0089 Ribosomal_protein_L23 RplW 667.0 0.47976011994003 0.52023988005997 0.107977874893175 0.730719726512719 0.419348800702947 0.622741851619544 0 0 0 0 K02893 0.0257142857142857 0.0 RP-L23Ae, RPL23A; large subunit ribosomal protein L23Ae path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 81.0 9.0 0.0 1.0 1.0 J 9.0 0.0 1.0 1.0 COG0089 Ribosomal_protein_L23 RplW 9.0 1.0 0.0 0.991895136598247 0.997854229783039 0.994874683190643 0.0059590931847919 0 0 1 1 K02895 0.9285714285714286 0.9914529914529916 RP-L24, MRPL24, rplX; large subunit ribosomal protein L24 path:map03010 Ribosome 26.0 674.0 0.0 1.0 1.0 J 325.0 349.0 1.0 1.0 COG0198 Ribosomal_protein_L24 RplX 674.0 0.4821958456973294 0.5178041543026706 0.303743611784807 0.612817294258449 0.458280453021628 0.309073682473642 0 0 0 0 K02896 0.8114285714285714 0.0 RP-L24e, RPL24; large subunit ribosomal protein L24e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 49.0 286.0 0.0 1.0 1.0 J 286.0 0.0 1.0 1.0 COG2075 Ribosomal_protein_L24E RPL24A 286.0 1.0 0.0 0.94589048012425 0.786713297886314 0.866301889005282 0.1591771822379361 0 0 1 1 K02897 0.0 0.8746438746438746 RP-L25, rplY; large subunit ribosomal protein L25 path:map03010 Ribosome 82.0 310.0 0.0 1.0 1.0 J 0.0 310.0 1.0 1.0 COG1825 Ribosomal_protein_L25_(general_stress_protein_Ctc) RplY 310.0 0.0 1.0 0.848665404101656 0.93271292115035 0.890689162626003 0.0840475170486939 0 0 1 1 K02899 0.0 0.98005698005698 RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27 path:map03010 Ribosome 70.0 344.0 343.0 2.0 0.997101449275362 J 0.0 345.0 2.0 0.997101449275362 COG0211 Ribosomal_protein_L27 RpmA 345.0 0.0 1.0 0.812161366409594 0.53959034779962 0.6758758571046071 0.272571018609974 0 0 1 1 K02902 0.0114285714285714 0.9031339031339032 RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28 path:map03010 Ribosome 38.0 335.0 333.0 2.0 0.99406528189911 J 4.0 333.0 3.0 0.982195845697329 COG0227 Ribosomal_protein_L28 RpmB 337.0 0.0118694362017804 0.9881305637982196 0.752933254026627 0.7760735124649 0.7645033832457635 0.0231402584382729 1 1 1 1 K02904 0.7828571428571428 0.8717948717948718 RP-L29, rpmC; large subunit ribosomal protein L29 path:map03010 Ribosome 36.0 582.0 0.0 1.0 1.0 J 276.0 306.0 1.0 1.0 COG0255 Ribosomal_protein_L29 RpmC 582.0 0.4742268041237113 0.5257731958762887 0.651230197801641 0.0110761159063912 0.3311531568540161 0.6401540818952498 0 1 0 1 K02906 0.9428571428571428 0.9886039886039886 RP-L3, MRPL3, rplC; large subunit ribosomal protein L3 path:map03010 Ribosome 112.0 681.0 680.0 2.0 0.998533724340176 J 335.0 347.0 2.0 0.998533724340176 COG0087 Ribosomal_protein_L3 RplC 682.0 0.4912023460410557 0.5087976539589443 0.582929093950113 0.0852203224521743 0.3340747082011436 0.4977087714979387 0 1 0 1 K02907 0.9342857142857144 0.6780626780626781 RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30 path:map03010 Ribosome 31.0 567.0 0.0 1.0 1.0 J 329.0 238.0 1.0 1.0 COG1841 Ribosomal_protein_L30/L7E RpmD 567.0 0.5802469135802469 0.419753086419753 0.641939082730958 0.619316069424574 0.630627576077766 0.022623013306384 0 1 0 1 K02908 0.7057142857142857 0.0 RP-L30e, RPL30; large subunit ribosomal protein L30e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 69.0 247.0 0.0 1.0 1.0 J 247.0 0.0 1.0 1.0 COG1911 Ribosomal_protein_L30E RPL30E 247.0 1.0 0.0 0.883662534143662 0.37590568579436 0.629784109969011 0.507756848349302 0 0 1 1 K02909 0.0 0.9772079772079773 RP-L31, rpmE; large subunit ribosomal protein L31 path:map03010 Ribosome 32.0 362.0 354.0 2.0 0.978378378378378 J 0.0 370.0 2.0 0.967567567567568 COG0254 Ribosomal_protein_L31 RpmE 370.0 0.0 1.0 0.0246258329644116 0.0540530566824837 0.0393394448234476 0.029427223718072 0 0 0 0 K02910 0.7971428571428572 0.0 RP-L31e, RPL31; large subunit ribosomal protein L31e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 56.0 279.0 0.0 1.0 1.0 J 279.0 0.0 1.0 1.0 COG2097 Ribosomal_protein_L31E RPL31A 279.0 1.0 0.0 0.919120628854932 0.665077248530238 0.792098938692585 0.254043380324694 0 0 1 1 K02911 0.0 0.8774928774928775 RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32 path:map03010 Ribosome 31.0 315.0 0.0 1.0 1.0 J 0.0 315.0 2.0 0.971428571428571 COG0333 Ribosomal_protein_L32 RpmF 315.0 0.0 1.0 0.710134393708028 0.54261404336426 0.6263742185361441 0.167520350343768 0 0 0 1 K02912 0.9228571428571428 0.0 RP-L32e, RPL32; large subunit ribosomal protein L32e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 70.0 323.0 319.0 2.0 0.987767584097859 J 327.0 0.0 3.0 0.960244648318043 COG1717 Ribosomal_protein_L32E Rpl32e 327.0 1.0 0.0 0.781287862009309 0.876083481887629 0.828685671948469 0.0947956198783199 0 0 1 1 K02913 0.0 0.7549857549857549 RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33 path:map03010 Ribosome 39.0 293.0 0.0 1.0 1.0 J 0.0 293.0 2.0 0.993174061433447 COG0267 Ribosomal_protein_L33 RpmG 293.0 0.0 1.0 0.278371982671564 0.358133825817125 0.3182529042443445 0.079761843145561 0 0 0 0 K02914 0.0 0.6353276353276354 RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34 path:map03010 Ribosome 37.0 223.0 0.0 1.0 1.0 J 0.0 223.0 2.0 0.991031390134529 COG0230 Ribosomal_protein_L34 RpmH 223.0 0.0 1.0 0.269108895874198 0.556553853416635 0.4128313746454165 0.287444957542437 0 0 0 0 K02915 0.3542857142857142 0.0 RP-L34e, RPL34; large subunit ribosomal protein L34e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 80.0 125.0 0.0 1.0 1.0 J 125.0 0.0 1.0 1.0 COG2174 Ribosomal_protein_L34E RPL34A 125.0 1.0 0.0 0.933587405684416 0.870143091383178 0.901865248533797 0.0634443143012379 0 0 1 1 K02916 0.0 0.8831908831908832 RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35 path:map03010 Ribosome 40.0 310.0 0.0 1.0 1.0 J 0.0 310.0 1.0 1.0 COG0291 Ribosomal_protein_L35 RpmI 310.0 0.0 1.0 0.0403367589759714 0.453096894407504 0.2467168266917377 0.4127601354315326 0 0 0 0 K02917 0.2971428571428571 0.0 RP-L35Ae, RPL35A; large subunit ribosomal protein L35Ae path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 72.0 105.0 0.0 1.0 1.0 J 105.0 0.0 1.0 1.0 COG2451 Ribosomal_protein_L35AE/L33A Rpl35A 105.0 1.0 0.0 0.994225743668017 0.86730187660188 0.9307638101349484 0.126923867066137 0 0 1 1 K02919 0.0 0.5527065527065527 RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36 path:map03010 Ribosome 37.0 206.0 0.0 1.0 1.0 J 0.0 206.0 1.0 1.0 COG0257 Ribosomal_protein_L36 RpmJ 206.0 0.0 1.0 0.732133155675063 0.840767223240056 0.7864501894575595 0.108634067564993 0 0 0 1 K02921 0.94 0.0 RP-L37Ae, RPL37A; large subunit ribosomal protein L37Ae path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 46.0 332.0 0.0 1.0 1.0 J 332.0 0.0 1.0 1.0 COG1997 Ribosomal_protein_L37AE/L43A RPL43A 332.0 1.0 0.0 0.736253202118996 0.376629744317179 0.5564414732180876 0.359623457801817 0 0 0 1 K02922 0.5085714285714286 0.0 RP-L37e, RPL37; large subunit ribosomal protein L37e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 43.0 178.0 0.0 1.0 1.0 J 178.0 0.0 1.0 1.0 COG2126 Ribosomal_protein_L37E RPL37A 178.0 1.0 0.0 0.813506784141565 0.841695334922673 0.827601059532119 0.028188550781108 0 0 1 1 K02923 0.1057142857142857 0.0 RP-L38e, RPL38; large subunit ribosomal protein L38e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 60.0 37.0 0.0 1.0 1.0 J 37.0 0.0 2.0 0.972972972972973 arCOG04057 37.0 1.0 0.0 0.767812630462217 0.959921948126927 0.863867289294572 0.1921093176647099 0 0 1 1 K02924 0.5571428571428572 0.0 RP-L39e, RPL39; large subunit ribosomal protein L39e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 43.0 196.0 0.0 1.0 1.0 J 196.0 0.0 1.0 1.0 COG2167 Ribosomal_protein_L39E RPL39 196.0 1.0 0.0 0.537747235943562 0.559708045224767 0.5487276405841646 0.021960809281205 0 0 0 1 K02926 0.0 0.9886039886039886 RP-L4, MRPL4, rplD; large subunit ribosomal protein L4 path:map03010 Ribosome 112.0 349.0 346.0 2.0 0.991477272727273 J 0.0 352.0 3.0 0.991477272727273 COG0088 Ribosomal_protein_L4 RplD 352.0 0.0 1.0 0.49410198494904 0.153406992760286 0.323754488854663 0.340694992188754 0 0 0 0 K02927 0.5857142857142857 0.0028490028490028 RP-L40e, RPL40, UBA52; ubiquitin-large subunit ribosomal protein L40e path:map03010,path:map04120,path:map04137,path:map05012,path:map05022,path:map05131,path:map05167,path:map05171 Ribosome,Ubiquitin mediated proteolysis,Mitophagy - animal,Parkinson disease,Pathways of neurodegeneration - multiple diseases,Shigellosis,Kaposi sarcoma-associated herpesvirus infection,Coronavirus disease - COVID-19 35.0 207.0 201.0 2.0 0.971830985915493 J 207.0 6.0 2.0 0.971830985915493 COG1552 Ribosomal_protein_L40E RPL40A 213.0 0.971830985915493 0.028169014084507 0.380855902441672 0.687779777678885 0.5343178400602785 0.306923875237213 0 0 0 0 K02928 0.0171428571428571 0.0 RP-L41e, RPL41; large subunit ribosomal protein L41e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 37.0 6.0 0.0 1.0 1.0 arCOG06624 6.0 1.0 0.0 0 0 0 0 K02929 0.8285714285714286 0.0 RP-L44e, RPL44; large subunit ribosomal protein L44e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 64.0 292.0 0.0 1.0 1.0 J 292.0 0.0 1.0 1.0 COG1631 Ribosomal_protein_L44E RPL42A 292.0 1.0 0.0 0.897336504768195 0.614413149067884 0.7558748269180395 0.282923355700311 0 0 1 1 K02930 0.9371428571428572 0.0 RP-L4e, RPL4; large subunit ribosomal protein L4e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 199.0 332.0 0.0 1.0 1.0 J 332.0 0.0 1.0 1.0 COG0469 Pyruvate_kinase PykF 332.0 1.0 0.0 0.987013755916238 0.542547330824487 0.7647805433703625 0.4444664250917509 0 0 1 1 K02931 0.9714285714285714 0.9829059829059827 RP-L5, MRPL5, rplE; large subunit ribosomal protein L5 path:map03010 Ribosome 114.0 691.0 0.0 1.0 1.0 J 344.0 347.0 1.0 1.0 COG0094 Ribosomal_protein_L5 RplE 691.0 0.4978292329956584 0.5021707670043415 0.779828607471584 0.764985205857818 0.772406906664701 0.0148434016137659 1 1 1 1 K02932 0.0028571428571428 0.0 RP-L5e, RPL5; large subunit ribosomal protein L5e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 214.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 1.0 1.0 0.0 0 0 0 0 K02933 0.9571428571428572 0.9914529914529916 RP-L6, MRPL6, rplF; large subunit ribosomal protein L6 path:map03010 Ribosome 87.0 684.0 0.0 1.0 1.0 J 336.0 348.0 1.0 1.0 COG0097 Ribosomal_protein_L6P/L9E RplF 684.0 0.4912280701754385 0.5087719298245614 0.605000662008167 0.290106370362432 0.4475535161852995 0.314894291645735 0 1 0 1 K02935 0.0 0.98005698005698 RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12 path:map03010 Ribosome 70.0 367.0 0.0 1.0 1.0 J 0.0 367.0 2.0 0.950953678474114 COG0222 Ribosomal_protein_L7/L12 RplL 367.0 0.0 1.0 0.355907118464409 0.818278299528368 0.5870927089963884 0.4623711810639589 0 0 0 0 K02936 0.9057142857142856 0.0 RP-L7Ae, RPL7A; large subunit ribosomal protein L7Ae path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 110.0 318.0 0.0 1.0 1.0 J 318.0 0.0 1.0 1.0 COG1358 Ribosomal_protein_L7Ae_or_related_RNA_K-turn-binding_protein Rpl7Ae 318.0 1.0 0.0 0.625788637681608 0.558298135962233 0.5920433868219205 0.0674905017193749 0 0 0 1 K02939 0.0 0.9658119658119658 RP-L9, MRPL9, rplI; large subunit ribosomal protein L9 path:map03010 Ribosome 84.0 339.0 0.0 1.0 1.0 J 0.0 339.0 1.0 1.0 COG0359 Ribosomal_protein_L9 RplI 339.0 0.0 1.0 0.812804107910843 0.495818060994924 0.6543110844528834 0.316986046915919 0 0 1 1 K02944 0.5171428571428571 0.0 RP-LX, rplX; large subunit ribosomal protein LX path:map03010 Ribosome 50.0 181.0 0.0 1.0 1.0 J 181.0 0.0 1.0 1.0 COG2157 Ribosomal_protein_L20A_(L18A) RPL20A 181.0 1.0 0.0 0.145956852954684 0.561699833051838 0.353828343003261 0.415742980097154 0 0 0 0 K02945 0.0257142857142857 0.9686609686609686 RP-S1, rpsA; small subunit ribosomal protein S1 path:map03010 Ribosome 79.0 400.0 348.0 9.0 0.793650793650794 J 10.0 490.0 12.0 0.829365079365079 COG0539 Ribosomal_protein_S1 RpsA 500.0 0.02 0.98 0.947798416488085 0.909314747493349 0.928556581990717 0.0384836689947361 1 1 1 1 K02946 0.92 0.9829059829059827 RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10 path:map03010 Ribosome 84.0 671.0 0.0 1.0 1.0 J 325.0 346.0 1.0 1.0 COG0051 Ribosomal_protein_S10 RpsJ 671.0 0.4843517138599106 0.5156482861400894 0.792383858071612 0.695693491407492 0.744038674739552 0.09669036666412 1 1 1 1 K02948 0.9514285714285714 0.9772079772079773 RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11 path:map03010 Ribosome 107.0 680.0 0.0 1.0 1.0 J 335.0 345.0 2.0 0.995588235294118 COG0100 Ribosomal_protein_S11 RpsK 680.0 0.4926470588235294 0.5073529411764706 0.600111099317704 0.115599713181042 0.357855406249373 0.484511386136662 0 1 0 1 K02950 0.9457142857142856 0.9686609686609686 RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12 path:map03010 Ribosome 91.0 677.0 0.0 1.0 1.0 J 336.0 341.0 1.0 1.0 COG0048 Ribosomal_protein_S12 RpsL 677.0 0.4963072378138848 0.5036927621861153 0.719525488902934 0.31614499107835 0.517835239990642 0.403380497824584 0 1 0 1 K02952 0.9485714285714286 0.9857549857549858 RP-S13, rpsM; small subunit ribosomal protein S13 path:map03010 Ribosome 83.0 680.0 0.0 1.0 1.0 J 334.0 346.0 1.0 1.0 COG0099 Ribosomal_protein_S13 RpsM 680.0 0.4911764705882352 0.5088235294117647 0.701057704949284 0.577534032293326 0.639295868621305 0.1235236726559579 0 1 0 1 K02954 0.7514285714285714 0.8376068376068376 RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14 path:map03010 Ribosome 33.0 584.0 0.0 1.0 1.0 J 269.0 315.0 1.0 1.0 COG0199 Ribosomal_protein_S14 RpsN 584.0 0.4606164383561644 0.5393835616438356 0.354232214961968 0.182071191913645 0.2681517034378065 0.172161023048323 0 0 0 0 K02955 0.0085714285714285 0.0 RP-S14e, RPS14; small subunit ribosomal protein S14e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 138.0 3.0 0.0 1.0 1.0 J 3.0 0.0 1.0 1.0 COG0100 Ribosomal_protein_S11 RpsK 3.0 1.0 0.0 0 0 0 0 K02956 0.8971428571428571 0.9886039886039886 RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15 path:map03010 Ribosome 70.0 665.0 0.0 1.0 1.0 J 317.0 348.0 1.0 1.0 COG0184 Ribosomal_protein_S15P/S13E RpsO 665.0 0.4766917293233083 0.5233082706766917 0.604689962430214 0.400862701487035 0.5027763319586245 0.203827260943179 0 1 0 1 K02959 0.0 0.9743589743589745 RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16 path:map03010 Ribosome 62.0 342.0 0.0 1.0 1.0 J 0.0 342.0 1.0 1.0 COG0228 Ribosomal_protein_S16 RpsP 342.0 0.0 1.0 0.0080823613868555 0.467090257164523 0.2375863092756892 0.4590078957776675 0 0 0 0 K02961 0.9542857142857144 0.9943019943019944 RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17 path:map03010 Ribosome 56.0 684.0 0.0 1.0 1.0 J 335.0 349.0 1.0 1.0 COG0186 Ribosomal_protein_S17 RpsQ 684.0 0.489766081871345 0.5102339181286549 0.164065210875441 0.0489390958516822 0.1065021533635615 0.1151261150237587 0 0 0 0 K02962 0.8114285714285714 0.0 RP-S17e, RPS17; small subunit ribosomal protein S17e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 47.0 290.0 0.0 1.0 1.0 J 290.0 0.0 1.0 1.0 COG1383 Ribosomal_protein_S17E RPS17A 290.0 1.0 0.0 0.593336958423163 0.145676775839798 0.3695068671314805 0.447660182583365 0 0 0 1 K02963 0.0 0.9715099715099716 RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18 path:map03010 Ribosome 51.0 349.0 0.0 1.0 1.0 J 0.0 349.0 1.0 1.0 COG0238 Ribosomal_protein_S18 RpsR 349.0 0.0 1.0 0.0646624876822866 0.388663357498995 0.2266629225906408 0.3240008698167084 0 0 0 0 K02964 0.0028571428571428 0.0 RP-S18e, RPS18; small subunit ribosomal protein S18e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 155.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0099 Ribosomal_protein_S13 RpsM 1.0 1.0 0.0 0 0 0 0 K02965 0.9428571428571428 0.9772079772079773 RP-S19, rpsS; small subunit ribosomal protein S19 path:map03010 Ribosome 60.0 676.0 0.0 1.0 1.0 J 333.0 343.0 1.0 1.0 COG0185 Ribosomal_protein_S19 RpsS 676.0 0.492603550295858 0.507396449704142 0.95757674628032 0.375874733284985 0.6667257397826525 0.581702012995335 1 1 1 1 K02966 0.9085714285714286 0.0 RP-S19e, RPS19; small subunit ribosomal protein S19e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 106.0 319.0 0.0 1.0 1.0 J 319.0 0.0 1.0 1.0 COG2238 Ribosomal_protein_S19E_(S16A) RPS19A 319.0 1.0 0.0 0.0423316765338662 0.400672586973513 0.2215021317536896 0.3583409104396468 0 0 0 0 K02967 0.9428571428571428 0.9886039886039886 RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2 path:map03010 Ribosome 121.0 682.0 679.0 2.0 0.995620437956204 J 331.0 354.0 3.0 0.995620437956204 COG0052 Ribosomal_protein_S2 RpsB 685.0 0.4832116788321168 0.5167883211678832 0.252873177434498 0.700335322035693 0.4766042497350955 0.447462144601195 0 0 0 0 K02968 0.0 0.9401709401709402 RP-S20, rpsT; small subunit ribosomal protein S20 path:map03010 Ribosome 64.0 333.0 0.0 1.0 1.0 J 0.0 333.0 1.0 1.0 COG0268 Ribosomal_protein_S20 RpsT 333.0 0.0 1.0 0.741536396124008 0.648914340562107 0.6952253683430575 0.092622055561901 0 0 0 1 K02970 0.0 0.7122507122507122 RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21 path:map03010 Ribosome 44.0 278.0 0.0 1.0 1.0 J 0.0 278.0 5.0 0.967625899280576 COG0828 Ribosomal_protein_S21 RpsU 278.0 0.0 1.0 0.0341309645823406 0.433883270172749 0.2340071173775448 0.3997523055904084 0 0 0 0 K02972 0.0 0.0028490028490028 sra; stationary-phase-induced ribosome-associated protein 45.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 2EN1Q 1.0 0.0 1.0 0 0 0 0 K02974 0.76 0.0 RP-S24e, RPS24; small subunit ribosomal protein S24e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 53.0 267.0 0.0 1.0 1.0 J 267.0 0.0 1.0 1.0 COG2004 Ribosomal_protein_S24E RPS24A 267.0 1.0 0.0 0.0780439837808605 0.140995794085175 0.1095198889330177 0.0629518103043145 0 0 0 0 K02975 0.18 0.0 RP-S25e, RPS25; small subunit ribosomal protein S25e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 59.0 64.0 0.0 1.0 1.0 J 64.0 0.0 1.0 1.0 COG4901 Ribosomal_protein_S25e RPS25 64.0 1.0 0.0 0.227078088407968 0.606521903011413 0.4167999957096905 0.3794438146034449 0 0 0 0 K02976 0.3057142857142857 0.0 RP-S26e, RPS26; small subunit ribosomal protein S26e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 78.0 112.0 0.0 1.0 1.0 J 112.0 0.0 1.0 1.0 COG4830 Ribosomal_protein_S26e RPS26B 112.0 1.0 0.0 0.2559044564508 0.608601948850627 0.4322532026507135 0.352697492399827 0 0 0 0 K02977 0.8171428571428572 0.0 RP-S27Ae, RPS27A, UBA80; ubiquitin-small subunit ribosomal protein S27Ae path:map03010,path:map04120,path:map04137,path:map05012,path:map05022,path:map05131,path:map05167,path:map05171 Ribosome,Ubiquitin mediated proteolysis,Mitophagy - animal,Parkinson disease,Pathways of neurodegeneration - multiple diseases,Shigellosis,Kaposi sarcoma-associated herpesvirus infection,Coronavirus disease - COVID-19 29.0 287.0 0.0 1.0 1.0 J 287.0 0.0 1.0 1.0 COG1998 Ribosomal_protein_S27AE RPS27ae 287.0 1.0 0.0 0.181113095386712 0.0711892098331856 0.1261511526099488 0.1099238855535264 0 0 0 0 K02978 0.8342857142857143 0.0 RP-S27e, RPS27; small subunit ribosomal protein S27e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 43.0 294.0 0.0 1.0 1.0 J 294.0 0.0 1.0 1.0 COG2051 Ribosomal_protein_S27E RPS27A 294.0 1.0 0.0 0.468610868156674 0.702480560695201 0.5855457144259375 0.233869692538527 0 0 0 0 K02979 0.9314285714285714 0.0 RP-S28e, RPS28; small subunit ribosomal protein S28e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 63.0 327.0 0.0 1.0 1.0 J 327.0 0.0 1.0 1.0 COG2053 Ribosomal_protein_S28E/S33 RPS28A 327.0 1.0 0.0 0.562974773725171 0.499963366421257 0.531469070073214 0.063011407303914 0 0 0 1 K02980 0.0628571428571428 0.0 RP-S29e, RPS29; small subunit ribosomal protein S29e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 44.0 22.0 0.0 1.0 1.0 J 22.0 0.0 1.0 1.0 COG0199 Ribosomal_protein_S14 RpsN 22.0 1.0 0.0 0.978676953752487 0.928758656938143 0.953717805345315 0.049918296814344 0 0 1 1 K02982 0.9342857142857144 0.9943019943019944 RP-S3, rpsC; small subunit ribosomal protein S3 path:map03010 Ribosome 105.0 681.0 0.0 1.0 1.0 J 330.0 351.0 1.0 1.0 COG0092 Ribosomal_protein_S3 RpsC 681.0 0.4845814977973568 0.5154185022026432 0.659916890397207 0.827205868452235 0.743561379424721 0.1672889780550279 0 1 0 1 K02983 0.2114285714285714 0.0 RP-S30e, RPS30; small subunit ribosomal protein S30e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 42.0 75.0 0.0 1.0 1.0 J 75.0 0.0 1.0 1.0 COG4919 Ribosomal_protein_S30 RPS30 75.0 1.0 0.0 0.23705689684114 0.488147462413629 0.3626021796273845 0.251090565572489 0 0 0 0 K02984 0.8714285714285714 0.0 RP-S3Ae, RPS3A; small subunit ribosomal protein S3Ae path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 125.0 310.0 0.0 1.0 1.0 J 310.0 0.0 1.0 1.0 COG1890 Ribosomal_protein_S3AE RPS3A 310.0 1.0 0.0 0.967112774655888 0.141788797223775 0.5544507859398314 0.8253239774321129 0 0 1 1 K02986 0.9542857142857144 0.9886039886039886 RP-S4, rpsD; small subunit ribosomal protein S4 path:map03010 Ribosome 71.0 694.0 0.0 1.0 1.0 J 335.0 359.0 1.0 1.0 COG0522 Ribosomal_protein_S4_or_related_protein RpsD 694.0 0.4827089337175792 0.5172910662824207 0.0406272954894637 0.0908028602715714 0.0657150778805175 0.0501755647821077 0 0 0 0 K02987 0.9628571428571427 0.0 RP-S4e, RPS4; small subunit ribosomal protein S4e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 160.0 337.0 0.0 1.0 1.0 J 337.0 0.0 1.0 1.0 COG1471 Ribosomal_protein_S4E RPS4A 337.0 1.0 0.0 0.0378956774048319 0.678905001334636 0.358400339369734 0.6410093239298041 0 0 0 0 K02988 0.9457142857142856 0.98005698005698 RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5 path:map03010 Ribosome 116.0 680.0 0.0 1.0 1.0 J 335.0 345.0 1.0 1.0 COG0098 Ribosomal_protein_S5 RpsE 680.0 0.4926470588235294 0.5073529411764706 0.562749170453597 0.30278567421455 0.4327674223340735 0.2599634962390469 0 1 0 1 K02990 0.0 0.9629629629629628 RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6 path:map03010 Ribosome 40.0 340.0 339.0 2.0 0.997067448680352 J 0.0 341.0 2.0 0.997067448680352 COG0360 Ribosomal_protein_S6 RpsF 341.0 0.0 1.0 0.377113613627869 0.848811272570789 0.612962443099329 0.47169765894292 0 0 0 0 K02991 0.9285714285714286 0.0 RP-S6e, RPS6; small subunit ribosomal protein S6e path:map01521,path:map03010,path:map04066,path:map04150,path:map04151,path:map04371,path:map04714,path:map04910,path:map05171,path:map05205 EGFR tyrosine kinase inhibitor resistance,Ribosome,HIF-1 signaling pathway,mTOR signaling pathway,PI3K-Akt signaling pathway,Apelin signaling pathway,Thermogenesis,Insulin signaling pathway,Coronavirus disease - COVID-19,Proteoglycans in cancer 81.0 326.0 0.0 1.0 1.0 J 326.0 0.0 1.0 1.0 COG2125 Ribosomal_protein_S6E_(S10) RPS6A 326.0 1.0 0.0 0.957423866443648 0.52142975855479 0.7394268124992189 0.4359941078888579 0 0 1 1 K02992 0.9457142857142856 0.9715099715099716 RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7 path:map03010 Ribosome 118.0 679.0 0.0 1.0 1.0 J 332.0 347.0 1.0 1.0 COG0049 Ribosomal_protein_S7 RpsG 679.0 0.4889543446244477 0.5110456553755522 0.944886579996802 0.759597827020593 0.8522422035086975 0.185288752976209 1 1 1 1 K02994 0.9657142857142856 0.9886039886039886 RP-S8, rpsH; small subunit ribosomal protein S8 path:map03010 Ribosome 81.0 687.0 0.0 1.0 1.0 J 340.0 347.0 1.0 1.0 COG0096 Ribosomal_protein_S8 RpsH 687.0 0.4949053857350801 0.50509461426492 0.164174211446398 0.708479747964472 0.436326979705435 0.544305536518074 0 0 0 0 K02995 0.92 0.0 RP-S8e, RPS8; small subunit ribosomal protein S8e path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 84.0 325.0 0.0 1.0 1.0 J 325.0 0.0 1.0 1.0 COG2007 Ribosomal_protein_S8E RPS8A 325.0 1.0 0.0 0.990485333176824 0.928849949587505 0.9596676413821644 0.0616353835893189 0 0 1 1 K02996 0.9371428571428572 0.9914529914529916 RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9 path:map03010 Ribosome 66.0 679.0 0.0 1.0 1.0 J 330.0 349.0 2.0 0.5139911634757 COG0103 Ribosomal_protein_S9 RpsI 679.0 0.4860088365243004 0.5139911634756995 0.241837165503207 0.618657424691459 0.430247295097333 0.376820259188252 0 0 0 0 K02998 0.0028571428571428 0.0 RP-SAe, RPSA; small subunit ribosomal protein SAe path:map03010,path:map05171 Ribosome,Coronavirus disease - COVID-19 297.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0052 Ribosomal_protein_S2 RpsB 1.0 1.0 0.0 0 0 0 0 K03007 0.0314285714285714 0.0 RPABC5, RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 path:map03020,path:map04623,path:map05016 RNA polymerase,Cytosolic DNA-sensing pathway,Huntington disease 65.0 11.0 0.0 1.0 1.0 K 11.0 0.0 1.0 1.0 COG1644 DNA-directed_RNA_polymerase,_subunit_N_(RpoN/RPB10) RPB10 11.0 1.0 0.0 0.900820405093033 0.983174834116814 0.9419976196049236 0.0823544290237809 0 0 1 1 K03008 0.0171428571428571 0.0 RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11 path:map03020,path:map05016 RNA polymerase,Huntington disease 89.0 6.0 0.0 1.0 1.0 K 6.0 0.0 1.0 1.0 COG1761 DNA-directed_RNA_polymerase,_subunit_L/RPAC2 RPB11 6.0 1.0 0.0 0.0138494698800349 0.0306432479853659 0.0222463589327004 0.0167937781053309 0 0 0 0 K03013 0.0571428571428571 0.0 RPABC1, RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 path:map03020,path:map04623,path:map05016 RNA polymerase,Cytosolic DNA-sensing pathway,Huntington disease 174.0 27.0 0.0 1.0 1.0 K 27.0 0.0 1.0 1.0 COG2012 DNA-directed_RNA_polymerase,_subunit_H,_RpoH/RPB5 RPB5 27.0 1.0 0.0 0.300238967860838 0.845403958068765 0.5728214629648015 0.545164990207927 0 0 0 0 K03014 0.2771428571428571 0.0 RPABC2, RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 path:map03020,path:map04623,path:map05016 RNA polymerase,Cytosolic DNA-sensing pathway,Huntington disease 64.0 99.0 0.0 1.0 1.0 K 99.0 0.0 1.0 1.0 COG1758 DNA-directed_RNA_polymerase,_subunit_K/omega RpoZ 99.0 1.0 0.0 0.305497593215372 0.730471106544868 0.51798434988012 0.424973513329496 0 0 0 0 K03019 0.0028571428571428 0.0 RPC11, POLR3K; DNA-directed RNA polymerase III subunit RPC11 path:map03020,path:map04623 RNA polymerase,Cytosolic DNA-sensing pathway 112.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG1594 DNA-directed_RNA_polymerase,_subunit_M/Transcription_elongation_factor_TFIIS RPB9 1.0 1.0 0.0 0 0 0 0 K03022 0.0 0.0028490028490028 RPC8, POLR3H; DNA-directed RNA polymerase III subunit RPC8 path:map03020,path:map04623 RNA polymerase,Cytosolic DNA-sensing pathway 412.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0153 Galactokinase GalK 1.0 0.0 1.0 0 0 0 0 K03027 0.0 0.0028490028490028 RPAC1, RPC40, POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1 path:map03020,path:map04623 RNA polymerase,Cytosolic DNA-sensing pathway 539.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 1.0 0.0 1.0 0 0 0 0 K03030 0.0514285714285714 0.0 PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11 path:map03050,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05169 Proteasome,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Epstein-Barr virus infection 102.0 23.0 22.0 2.0 0.958333333333333 O 24.0 0.0 1.0 1.0 COG1310 Proteasome_lid_subunit_RPN8/RPN11,_contains_Jab1/MPN_domain_metalloenzyme_(JAMM)_motif Rri1 24.0 1.0 0.0 0.834720532623594 0.979502917195008 0.907111724909301 0.144782384571414 0 0 1 1 K03040 0.0028571428571428 0.9886039886039886 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] path:map03020 RNA polymerase 211.0 369.0 368.0 2.0 0.997297297297297 K 1.0 369.0 2.0 0.997297297297297 COG0202 DNA-directed_RNA_polymerase,_alpha_subunit/40_kD_subunit RpoA 370.0 0.0027027027027027 0.9972972972972972 0.950494873842524 0.289965611578142 0.620230242710333 0.6605292622643819 0 0 1 1 K03041 0.9485714285714286 0.0 rpoA1; DNA-directed RNA polymerase subunit A' [EC:2.7.7.6] path:map03020 RNA polymerase 672.0 346.0 341.0 3.0 0.977401129943503 K 353.0 0.0 3.0 0.977401129943503 COG0086 DNA-directed_RNA_polymerase,_beta'_subunit/160_kD_subunit RpoC 353.0 1.0 0.0 0.838184985206698 0.648290899419091 0.7432379423128945 0.189894085787607 0 0 1 1 K03042 0.7942857142857143 0.0 "rpoA2; DNA-directed RNA polymerase subunit A"" [EC:2.7.7.6]" path:map03020 RNA polymerase 234.0 273.0 260.0 2.0 0.954545454545455 K 286.0 0.0 3.0 0.98951048951049 COG0086 DNA-directed_RNA_polymerase,_beta'_subunit/160_kD_subunit RpoC 286.0 1.0 0.0 0.0928173190749999 0.0480451507906997 0.0704312349328498 0.0447721682843002 0 0 0 0 K03043 0.0 0.9772079772079773 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] path:map03020 RNA polymerase 798.0 362.0 0.0 1.0 1.0 K 0.0 362.0 1.0 1.0 COG0085 DNA-directed_RNA_polymerase,_beta_subunit/140_kD_subunit RpoB 362.0 0.0 1.0 0.420244091053332 0.163315435179404 0.291779763116368 0.256928655873928 0 0 0 0 K03044 0.5114285714285715 0.0 rpoB1; DNA-directed RNA polymerase subunit B' [EC:2.7.7.6] path:map03020 RNA polymerase 556.0 184.0 0.0 1.0 1.0 K 184.0 0.0 1.0 1.0 COG0085 DNA-directed_RNA_polymerase,_beta_subunit/140_kD_subunit RpoB 184.0 1.0 0.0 0.928505585927903 0.944300363491446 0.9364029747096744 0.0157947775635429 0 0 1 1 K03045 0.3085714285714285 0.0 "rpoB2; DNA-directed RNA polymerase subunit B"" [EC:2.7.7.6]" path:map03020 RNA polymerase 469.0 111.0 0.0 1.0 1.0 K 110.0 0.0 1.0 1.0 COG0085 DNA-directed_RNA_polymerase,_beta_subunit/140_kD_subunit RpoB 110.0 1.0 0.0 0.199125134080177 0.015177805625315 0.107151469852746 0.183947328454862 0 0 0 0 K03046 0.0028571428571428 0.9829059829059827 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] path:map03020 RNA polymerase 831.0 394.0 390.0 6.0 0.970443349753695 K 1.0 405.0 6.0 0.948275862068966 COG0086 DNA-directed_RNA_polymerase,_beta'_subunit/160_kD_subunit RpoC 406.0 0.0024630541871921 0.9975369458128078 0.692331395905579 0.965914912821325 0.8291231543634521 0.273583516915746 0 0 0 1 K03047 0.9514285714285714 0.0 rpoD; DNA-directed RNA polymerase subunit D [EC:2.7.7.6] path:map03020 RNA polymerase 117.0 337.0 0.0 1.0 1.0 K 337.0 0.0 1.0 1.0 COG0202 DNA-directed_RNA_polymerase,_alpha_subunit/40_kD_subunit RpoA 337.0 1.0 0.0 0.474485053826414 0.508225526057419 0.4913552899419164 0.033740472231005 0 0 0 0 K03048 0.0 0.0626780626780626 rpoE; DNA-directed RNA polymerase subunit delta path:map03020 RNA polymerase 96.0 21.0 0.0 1.0 1.0 K 0.0 22.0 2.0 0.954545454545455 COG3343 DNA-directed_RNA_polymerase,_delta_subunit RpoE 22.0 0.0 1.0 0.0011161720347149 0.0018739601075941 0.0014950660711545 0.0007577880728792 0 0 0 0 K03049 0.9285714285714286 0.0 rpoE1; DNA-directed RNA polymerase subunit E' [EC:2.7.7.6] path:map03020 RNA polymerase 123.0 327.0 0.0 1.0 1.0 K 327.0 0.0 1.0 1.0 COG1095 DNA-directed_RNA_polymerase,_subunit_E'/Rpb7 RPB7 327.0 1.0 0.0 0.931352155340352 0.908035714649641 0.9196939349949964 0.023316440690711 0 0 1 1 K03050 0.8771428571428571 0.0 "rpoE2; DNA-directed RNA polymerase subunit E"" [EC:2.7.7.6]" path:map03020 RNA polymerase 44.0 310.0 0.0 1.0 1.0 K 310.0 0.0 1.0 1.0 COG2093 RNA_polymerase_subunit_RPABC4/transcription_elongation_factor_Spt4 Spt4 310.0 1.0 0.0 0.535349233807868 0.560676443235416 0.5480128385216421 0.0253272094275479 0 0 0 1 K03051 0.7571428571428571 0.0 rpoF; DNA-directed RNA polymerase subunit F [EC:2.7.7.6] path:map03020 RNA polymerase 64.0 266.0 0.0 1.0 1.0 K 266.0 0.0 1.0 1.0 COG1460 DNA-directed_RNA_polymerase,_subunit_F RpoF 266.0 1.0 0.0 0.348741258085378 0.229581142525341 0.2891612003053595 0.1191601155600369 0 0 0 0 K03052 0.0914285714285714 0.0 rpoG; DNA-directed RNA polymerase subunit G [EC:2.7.7.6] path:map03020 RNA polymerase 78.0 7.0 0.0 1.0 1.0 K 32.0 0.0 1.0 1.0 arCOG04271 32.0 1.0 0.0 0.0002421528156295 0.0004215413966936 0.0003318471061615 0.0001793885810641 0 0 0 0 K03053 0.8628571428571429 0.0 rpoH; DNA-directed RNA polymerase subunit H [EC:2.7.7.6] path:map03020 RNA polymerase 52.0 303.0 0.0 1.0 1.0 K 303.0 0.0 1.0 1.0 COG2012 DNA-directed_RNA_polymerase,_subunit_H,_RpoH/RPB5 RPB5 303.0 1.0 0.0 0.47677971552826 0.6293895243885 0.55308461995838 0.15260980886024 0 0 0 0 K03054 0.0057142857142857 0.0 rpoI; DNA-directed RNA polymerase subunit I [EC:2.7.7.6] 63.0 3.0 0.0 1.0 1.0 K 3.0 0.0 2.0 0.666666666666667 COG1719 Predicted_hydrocarbon_binding_protein,_contains_4VR_domain 3.0 1.0 0.0 0 0 0 0 K03055 0.7371428571428571 0.0 rpoK; DNA-directed RNA polymerase subunit K [EC:2.7.7.6] path:map03020 RNA polymerase 40.0 260.0 0.0 1.0 1.0 K 260.0 0.0 1.0 1.0 COG1758 DNA-directed_RNA_polymerase,_subunit_K/omega RpoZ 260.0 1.0 0.0 0.0452808644960477 0.0237371787578078 0.0345090216269277 0.0215436857382399 0 0 0 0 K03056 0.7542857142857143 0.0 rpoL; DNA-directed RNA polymerase subunit L [EC:2.7.7.6] path:map03020 RNA polymerase 48.0 265.0 0.0 1.0 1.0 K 265.0 0.0 1.0 1.0 COG1761 DNA-directed_RNA_polymerase,_subunit_L/RPAC2 RPB11 265.0 1.0 0.0 0.0105473353280627 0.20837562438597 0.1094614798570163 0.1978282890579072 0 0 0 0 K03057 0.84 0.0 tfs; transcription factor S 37.0 416.0 0.0 1.0 1.0 K 422.0 0.0 2.0 0.985781990521327 COG1594 DNA-directed_RNA_polymerase,_subunit_M/Transcription_elongation_factor_TFIIS RPB9 422.0 1.0 0.0 0.204299222428058 0.127798341645444 0.166048782036751 0.076500880782614 0 0 0 0 K03058 0.8971428571428571 0.0 rpoN; DNA-directed RNA polymerase subunit N [EC:2.7.7.6] path:map03020 RNA polymerase 49.0 310.0 305.0 2.0 0.984126984126984 K 315.0 0.0 1.0 1.0 COG1644 DNA-directed_RNA_polymerase,_subunit_N_(RpoN/RPB10) RPB10 315.0 1.0 0.0 0.116370138893476 0.0371023457036547 0.0767362422985653 0.0792677931898213 0 0 0 0 K03059 0.5085714285714286 0.0 rpoP; DNA-directed RNA polymerase subunit P [EC:2.7.7.6] path:map03020 RNA polymerase 33.0 181.0 0.0 1.0 1.0 K 181.0 0.0 1.0 1.0 COG1996 DNA-directed_RNA_polymerase,_subunit_RPC12/RpoP,_contains_C4-type_Zn-finger RPC10 181.0 1.0 0.0 0.496061206697189 0.678642572254671 0.58735188947593 0.1825813655574819 0 0 0 0 K03060 0.0 0.6182336182336182 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] path:map03020 RNA polymerase 33.0 220.0 0.0 1.0 1.0 K 0.0 221.0 4.0 0.981900452488688 COG1758 DNA-directed_RNA_polymerase,_subunit_K/omega RpoZ 221.0 0.0 1.0 0.0016445153208658 0.0245337590188257 0.0130891371698457 0.0228892436979599 0 0 0 0 K03061 0.0028571428571428 0.0 PSMC2, RPT1; 26S proteasome regulatory subunit T1 path:map03050,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05169 Proteasome,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Epstein-Barr virus infection 306.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0554 Glycerol_kinase GlpK 1.0 1.0 0.0 0 0 0 0 K03063 0.0028571428571428 0.0 PSMC4, RPT3; 26S proteasome regulatory subunit T3 path:map03050,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05169 Proteasome,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Epstein-Barr virus infection 414.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG1222 ATP-dependent_26S_proteasome_regulatory_subunit RPT1 1.0 1.0 0.0 0 0 0 0 K03064 0.0028571428571428 0.0 PSMC6, RPT4; 26S proteasome regulatory subunit T4 path:map03050,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05169 Proteasome,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Epstein-Barr virus infection 104.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG1222 ATP-dependent_26S_proteasome_regulatory_subunit RPT1 1.0 1.0 0.0 0 0 0 0 K03066 0.0028571428571428 0.0 PSMC5, RPT6; 26S proteasome regulatory subunit T6 path:map03050,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05169 Proteasome,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Epstein-Barr virus infection 71.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0554 Glycerol_kinase GlpK 1.0 1.0 0.0 0 0 0 0 K03070 0.0142857142857142 0.9857549857549858 secA; preprotein translocase subunit SecA [EC:7.4.2.8] path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 476.0 395.0 384.0 4.0 0.949519230769231 U 5.0 411.0 4.0 0.944711538461538 COG0653 Preprotein_translocase_subunit_SecA_(ATPase,_RNA_helicase) SecA 416.0 0.0120192307692307 0.9879807692307692 0.97553367759507 0.974504164155134 0.975018920875102 0.001029513439936 1 1 1 1 K03071 0.0 0.1937321937321937 secB; preprotein translocase subunit SecB path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 97.0 67.0 0.0 1.0 1.0 U 0.0 69.0 2.0 0.971014492753623 COG1952 Preprotein_translocase_subunit_SecB SecB 69.0 0.0 1.0 0.0179724185814329 0.101407257471858 0.0596898380266454 0.0834348388904251 0 0 0 0 K03072 0.5 0.8888888888888888 secD; preprotein translocase subunit SecD path:map03060,path:map03070 Protein export,Bacterial secretion system 163.0 575.0 574.0 2.0 0.998263888888889 U 181.0 394.0 2.0 0.776041666666667 COG0342 Preprotein_translocase_subunit_SecD SecD 575.0 0.3147826086956521 0.6852173913043478 0.557054509519961 0.0423032635783105 0.2996788865491357 0.5147512459416506 0 1 0 1 K03073 0.0 0.8404558404558404 secE; preprotein translocase subunit SecE path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 38.0 296.0 0.0 1.0 1.0 U 0.0 296.0 4.0 0.986486486486486 COG0690 Preprotein_translocase_subunit_SecE SecE 296.0 0.0 1.0 0.0027170710422976 0.706301616468554 0.3545093437554258 0.7035845454262565 0 0 0 0 K03074 0.4857142857142857 0.7122507122507122 secF; preprotein translocase subunit SecF path:map03060,path:map03070 Protein export,Bacterial secretion system 154.0 424.0 0.0 1.0 1.0 U 170.0 254.0 1.0 1.0 COG0341 Preprotein_translocase_subunit_SecF SecF 424.0 0.4009433962264151 0.5990566037735849 0.660751789975399 0.528478668546773 0.594615229261086 0.132273121428626 0 1 0 1 K03075 0.0 0.8746438746438746 secG; preprotein translocase subunit SecG path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 39.0 306.0 305.0 2.0 0.996742671009772 U 0.0 307.0 4.0 0.986970684039088 COG1314 Protein_translocase_subunit_SecG SecG 307.0 0.0 1.0 0.369791490019039 0.409376098926668 0.3895837944728535 0.0395846089076289 0 0 0 0 K03076 0.8771428571428571 0.9943019943019944 secY; preprotein translocase subunit SecY path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 247.0 671.0 0.0 1.0 1.0 U 313.0 358.0 2.0 0.533532041728763 COG0201 Preprotein_translocase_subunit_SecY SecY 671.0 0.4664679582712369 0.533532041728763 0.711781509797213 0.885569290019281 0.798675399908247 0.1737877802220679 0 1 0 1 K03077 0.0914285714285714 0.245014245014245 araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] path:map00040,path:map00053,path:map01100,path:map01120 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 157.0 136.0 134.0 2.0 0.985507246376812 G 35.0 103.0 2.0 0.985507246376812 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 138.0 0.2536231884057971 0.7463768115942029 0.984122373374121 0.890812988120258 0.9374676807471896 0.093309385253863 1 1 1 1 K03078 0.0 0.0142450142450142 ulaD, sgaH, sgbH; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] path:map00040,path:map00053,path:map01100,path:map01120 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 166.0 6.0 5.0 2.0 0.857142857142857 G 0.0 7.0 1.0 1.0 COG0269 3-keto-L-gulonate-6-phosphate_decarboxylase UlaD 7.0 0.0 1.0 0.0334369291046976 0.0667909783462653 0.0501139537254814 0.0333540492415676 0 0 0 0 K03079 0.02 0.074074074074074 ulaE, sgaU, sgbU; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] path:map00040,path:map00053,path:map01100,path:map01120 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 122.0 49.0 0.0 1.0 1.0 G 9.0 43.0 3.0 0.692307692307692 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 52.0 0.173076923076923 0.8269230769230769 0.0279924191659706 0.0439358901113643 0.0359641546386674 0.0159434709453937 0 0 0 0 K03086 0.0428571428571428 0.9857549857549858 rpoD; RNA polymerase primary sigma factor path:map02040 Flagellar assembly 46.0 693.0 683.0 4.0 0.977433004231312 K 17.0 691.0 6.0 0.956276445698166 COG0568 DNA-directed_RNA_polymerase,_sigma_subunit_(sigma70/sigma32) RpoD 708.0 0.0240112994350282 0.9759887005649718 0.0150100318374816 0.452807282910743 0.2339086573741123 0.4377972510732614 0 0 0 0 K03087 0.0142857142857142 0.1908831908831909 rpoS; RNA polymerase nonessential primary-like sigma factor path:map02026,path:map05111 Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 197.0 122.0 0.0 1.0 1.0 K 5.0 117.0 2.0 0.967213114754098 COG0568 DNA-directed_RNA_polymerase,_sigma_subunit_(sigma70/sigma32) RpoD 122.0 0.040983606557377 0.9590163934426228 0.0072929424190696 0.0940837168031736 0.0506883296111215 0.086790774384104 0 0 0 0 K03088 0.0 0.0 rpoE; RNA polymerase sigma-70 factor, ECF subfamily 2788.0 2782.0 6.0 0.993939393939394 K 0.0 0.0 17.0 0.9607982893799 COG1595 DNA-directed_RNA_polymerase_specialized_sigma_subunit,_sigma24_family RpoE 0.0 0 0 0 0 K03089 0.0 0.245014245014245 rpoH; RNA polymerase sigma-32 factor 212.0 121.0 0.0 1.0 1.0 K 0.0 121.0 1.0 1.0 COG0568 DNA-directed_RNA_polymerase,_sigma_subunit_(sigma70/sigma32) RpoD 121.0 0.0 1.0 0.0007172136127665 0.0021108087259845 0.0014140111693755 0.001393595113218 0 0 0 0 K03090 0.0 0.2022792022792023 sigB; RNA polymerase sigma-B factor 166.0 106.0 102.0 2.0 0.963636363636364 K 0.0 110.0 3.0 0.927272727272727 COG1191 DNA-directed_RNA_polymerase_specialized_sigma_subunit FliA 110.0 0.0 1.0 0.736630476268039 0.873501412637704 0.8050659444528715 0.1368709363696649 0 0 0 1 K03091 0.0 0.1965811965811965 sigH; RNA polymerase sporulation-specific sigma factor 99.0 230.0 0.0 1.0 1.0 K 0.0 230.0 3.0 0.669565217391304 COG1191 DNA-directed_RNA_polymerase_specialized_sigma_subunit FliA 230.0 0.0 1.0 0.0052502577879329 0.0619211484833649 0.0335857031356488 0.056670890695432 0 0 0 0 K03092 0.0 0.5925925925925926 rpoN; RNA polymerase sigma-54 factor path:map02020,path:map02040,path:map05111 Two-component system,Flagellar assembly,Biofilm formation - Vibrio cholerae 218.0 222.0 0.0 1.0 1.0 K 0.0 222.0 1.0 1.0 COG1508 DNA-directed_RNA_polymerase_specialized_sigma_subunit,_sigma54_homolog RpoN 222.0 0.0 1.0 0.28284108018603 0.178214361143633 0.2305277206648315 0.1046267190423969 0 0 0 0 K03093 0.0028571428571428 0.0968660968660968 sigI; RNA polymerase sigma factor 91.0 39.0 0.0 1.0 1.0 K 1.0 38.0 2.0 0.743589743589744 COG1191 DNA-directed_RNA_polymerase_specialized_sigma_subunit FliA 39.0 0.0256410256410256 0.9743589743589745 0.0068442962101529 0.0293047211293384 0.0180745086697456 0.0224604249191854 0 0 0 0 K03095 0.0 0.0341880341880341 sprL; SprT-like protein 144.0 12.0 0.0 1.0 1.0 S 0.0 12.0 1.0 1.0 COG3091 Predicted_Zn-dependent_metalloprotease,_SprT_family SprT 12.0 0.0 1.0 0.0043773982571229 0.01029489971641 0.0073361489867664 0.0059175014592871 0 0 0 0 K03098 0.0028571428571428 0.1396011396011396 APOD; apolipoprotein D and lipocalin family protein 99.0 60.0 0.0 1.0 1.0 M 1.0 59.0 1.0 1.0 COG3040 Bacterial_lipocalin_Blc Blc 60.0 0.0166666666666666 0.9833333333333332 0.0109841746695435 0.0290338588018544 0.0200090167356989 0.0180496841323109 0 0 0 0 K03099 0.0028571428571428 0.0 SOS; son of sevenless path:map01521,path:map01522,path:map04010,path:map04012,path:map04013,path:map04014,path:map04062,path:map04068,path:map04072,path:map04150,path:map04151,path:map04320,path:map04510,path:map04540,path:map04630,path:map04650,path:map04660,path:map04662,path:map04664,path:map04714,path:map04722,path:map04810,path:map04910,path:map04912,path:map04915,path:map04917,path:map04926,path:map04935,path:map05034,path:map05160,path:map05161,path:map05163,path:map05165,path:map05200,path:map05205,path:map05206,path:map05207,path:map05208,path:map05210,path:map05211,path:map05213,path:map05214,path:map05215,path:map05220,path:map05221,path:map05223,path:map05224,path:map05225,path:map05226,path:map05231 EGFR tyrosine kinase inhibitor resistance,Endocrine resistance,MAPK signaling pathway,ErbB signaling pathway,MAPK signaling pathway - fly,Ras signaling pathway,Chemokine signaling pathway,FoxO signaling pathway,Phospholipase D signaling pathway,mTOR signaling pathway,PI3K-Akt signaling pathway,Dorso-ventral axis formation,Focal adhesion,Gap junction,JAK-STAT signaling pathway,Natural killer cell mediated cytotoxicity,T cell receptor signaling pathway,B cell receptor signaling pathway,Fc epsilon RI signaling pathway,Thermogenesis,Neurotrophin signaling pathway,Regulation of actin cytoskeleton,Insulin signaling pathway,GnRH signaling pathway,Estrogen signaling pathway,Prolactin signaling pathway,Relaxin signaling pathway,Growth hormone synthesis, secretion and action,Alcoholism,Hepatitis C,Hepatitis B,Human cytomegalovirus infection,Human papillomavirus infection,Pathways in cancer,Proteoglycans in cancer,MicroRNAs in cancer,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species,Colorectal cancer,Renal cell carcinoma,Endometrial cancer,Glioma,Prostate cancer,Chronic myeloid leukemia,Acute myeloid leukemia,Non-small cell lung cancer,Breast cancer,Hepatocellular carcinoma,Gastric cancer,Choline metabolism in cancer 142.0 1.0 0.0 1.0 1.0 FG 1.0 0.0 1.0 1.0 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 1.0 1.0 0.0 0 0 0 0 K03100 0.0285714285714285 0.96011396011396 lepB; signal peptidase I [EC:3.4.21.89] path:map03060 Protein export 6.0 518.0 515.0 3.0 0.992337164750958 U 11.0 506.0 2.0 0.994252873563219 COG0681 Signal_peptidase_I LepB 517.0 0.0212765957446808 0.9787234042553192 0.0184672161007282 0.377372500790366 0.1979198584455471 0.3589052846896378 0 0 0 0 K03101 0.0685714285714285 0.8888888888888888 lspA; signal peptidase II [EC:3.4.23.36] path:map03060 Protein export 27.0 287.0 200.0 4.0 0.761273209549072 MU 24.0 353.0 2.0 0.997347480106101 COG0597 Lipoprotein_signal_peptidase LspA 377.0 0.0636604774535809 0.9363395225464192 0.0383074293627515 0.142169407817091 0.0902384185899212 0.1038619784543395 0 0 0 0 K03105 0.6371428571428571 0.0 SRP19; signal recognition particle subunit SRP19 path:map03060 Protein export 65.0 139.0 54.0 2.0 0.620535714285714 U 224.0 0.0 1.0 1.0 COG1400 Signal_recognition_particle_subunit_SEC65 SEC65 224.0 1.0 0.0 0.272810231341436 0.461280586257537 0.3670454087994865 0.1884703549161009 0 0 0 0 K03106 0.8971428571428571 0.8575498575498576 SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 320.0 623.0 0.0 1.0 1.0 U 318.0 305.0 1.0 1.0 COG0541 Signal_recognition_particle_GTPase Ffh 623.0 0.5104333868378812 0.4895666131621188 0.972723221816444 0.729778489260301 0.8512508555383724 0.242944732556143 1 1 1 1 K03110 0.8942857142857142 0.8603988603988604 ftsY; fused signal recognition particle receptor path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 132.0 591.0 559.0 8.0 0.920560747663551 U 325.0 317.0 11.0 0.962616822429906 COG0552 Signal_recognition_particle_GTPase_FtsY FtsY 642.0 0.5062305295950156 0.4937694704049844 0.0024288341915768 0.448967931344758 0.2256983827681674 0.4465390971531812 0 0 0 0 K03111 0.0057142857142857 0.9943019943019944 ssb; single-strand DNA-binding protein path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 20.0 605.0 602.0 2.0 0.995065789473684 L 2.0 606.0 4.0 0.983552631578947 COG0629 Single-stranded_DNA-binding_protein Ssb 608.0 0.0032894736842105 0.9967105263157896 0.1829928463252 0.384376096582981 0.2836844714540905 0.201383250257781 0 0 0 0 K03112 0.0 0.0826210826210826 damX; DamX protein 47.0 8.0 1.0 5.0 0.296296296296296 U 0.0 30.0 8.0 0.633333333333333 COG3266 Cell_division_protein_DamX,_binds_to_the_septal_ring,_contains_C-terminal_SPOR_domain DamX 30.0 0.0 1.0 0.0333584586724107 0.0614860356126527 0.0474222471425316 0.028127576940242 0 0 0 0 K03113 0.9342857142857144 0.2279202279202279 EIF1, SUI1; translation initiation factor 1 63.0 440.0 0.0 1.0 1.0 J 360.0 80.0 1.0 1.0 COG0023 Translation_initiation_factor_1_(eIF-1/SUI1) SUI1 440.0 0.8181818181818182 0.1818181818181818 0.858866634620421 0.388828765798917 0.623847700209669 0.470037868821504 1 1 1 1 K03116 0.4142857142857143 0.7122507122507122 tatA; sec-independent protein translocase protein TatA path:map03060,path:map03070 Protein export,Bacterial secretion system 19.0 591.0 0.0 1.0 1.0 U 207.0 385.0 3.0 0.996621621621622 COG1826 Twin-arginine_protein_secretion_pathway_components_TatA_and_TatB TatA 592.0 0.3496621621621621 0.6503378378378378 0.454824624254038 0.0131276876230855 0.2339761559385617 0.4416969366309525 0 0 0 0 K03117 0.0285714285714285 0.4558404558404558 tatB; sec-independent protein translocase protein TatB path:map03060,path:map03070 Protein export,Bacterial secretion system 40.0 171.0 170.0 2.0 0.994186046511628 U 10.0 162.0 2.0 0.994186046511628 COG1826 Twin-arginine_protein_secretion_pathway_components_TatA_and_TatB TatA 172.0 0.0581395348837209 0.9418604651162792 0.0228319917481255 0.0135987602071113 0.0182153759776184 0.0092332315410141 0 0 0 0 K03118 0.42 0.7264957264957265 tatC; sec-independent protein translocase protein TatC path:map03060,path:map03070 Protein export,Bacterial secretion system 97.0 485.0 483.0 3.0 0.993852459016393 U 215.0 273.0 5.0 0.987704918032787 COG0805 Twin-arginine_protein_secretion_pathway_component_TatC TatC 488.0 0.4405737704918033 0.5594262295081968 0.0020498248054392 0.182120202015414 0.0920850134104266 0.1800703772099748 0 0 0 0 K03119 0.0 0.1054131054131054 tauD; taurine dioxygenase [EC:1.14.11.17] path:map00430,path:map00920 Taurine and hypotaurine metabolism,Sulfur metabolism 148.0 97.0 94.0 2.0 0.97 Q 0.0 100.0 2.0 0.99 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 100.0 0.0 1.0 0.0004588047498533 0.0015724355257085 0.0010156201377809 0.0011136307758552 0 0 0 0 K03120 0.9285714285714286 0.0 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein path:map03022,path:map05016,path:map05017,path:map05165,path:map05166,path:map05203 Basal transcription factors,Huntington disease,Spinocerebellar ataxia,Human papillomavirus infection,Human T-cell leukemia virus 1 infection,Viral carcinogenesis 117.0 470.0 469.0 2.0 0.997876857749469 K 471.0 0.0 1.0 1.0 COG2101 TATA-box_binding_protein_(TBP),_component_of_TFIID_and_TFIIIB SPT15 471.0 1.0 0.0 0.961417406749933 0.978207014765636 0.9698122107577845 0.0167896080157029 0 0 1 1 K03124 0.9428571428571428 0.0 TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB path:map03022,path:map05017,path:map05203 Basal transcription factors,Spinocerebellar ataxia,Viral carcinogenesis 100.0 957.0 954.0 2.0 0.996875 K 960.0 0.0 1.0 1.0 COG1405 Transcription_initiation_factor_TFIIIB,_Brf1_subunit/Transcription_initiation_factor_TFIIB SUA7 960.0 1.0 0.0 0.289600898796836 0.90482414208984 0.597212520443338 0.615223243293004 0 0 0 0 K03136 0.7657142857142857 0.0 TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha path:map03022,path:map05203 Basal transcription factors,Viral carcinogenesis 96.0 276.0 0.0 1.0 1.0 K 276.0 0.0 1.0 1.0 COG1675 Transcription_initiation_factor_IIE,_alpha_subunit TFA1 276.0 1.0 0.0 0.0553613796789502 0.429700384873688 0.2425308822763191 0.3743390051947378 0 0 0 0 K03146 0.4057142857142857 0.0712250712250712 THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 228.0 166.0 154.0 2.0 0.932584269662921 H 152.0 26.0 1.0 1.0 COG1635 Thiazole_synthase/Archaeal_ribulose_1,5-bisphosphate_synthetase THI4 178.0 0.8539325842696629 0.146067415730337 0.326857237855268 0.240437012358996 0.2836471251071319 0.0864202254962719 0 0 0 0 K03147 0.44 0.5868945868945868 thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 371.0 428.0 0.0 1.0 1.0 H 202.0 226.0 3.0 0.983644859813084 COG0422 4-amino-2-methyl-5-hydroxymethylpyrimidine_(HMP)_synthase_ThiC ThiC 428.0 0.4719626168224299 0.5280373831775701 0.485419027335135 0.619577239427572 0.5524981333813535 0.134158212092437 0 0 0 0 K03148 0.1085714285714285 0.2165242165242165 thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73] path:map00730,path:map01100,path:map01240,path:map04122 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 99.0 129.0 128.0 2.0 0.992307692307692 H 43.0 87.0 2.0 0.938461538461538 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 130.0 0.3307692307692307 0.6692307692307692 0.224566733953915 0.932819509260726 0.5786931216073204 0.708252775306811 0 0 0 0 K03149 0.02 0.5356125356125356 thiG; thiazole synthase [EC:2.8.1.10] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 199.0 216.0 210.0 4.0 0.96 H 7.0 218.0 4.0 0.831111111111111 COG2022 Thiazole_synthase_ThiGH,_ThiG_subunit_(thiamin_biosynthesis) ThiG 225.0 0.0311111111111111 0.9688888888888888 0.152582838711741 0.645234225937382 0.3989085323245614 0.492651387225641 0 0 0 0 K03150 0.0257142857142857 0.2735042735042735 thiH; 2-iminoacetate synthase [EC:4.1.99.19] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 247.0 91.0 43.0 3.0 0.631944444444444 C 13.0 130.0 3.0 0.958333333333333 COG0502 Biotin_synthase_or_related_enzyme BioB 143.0 0.0909090909090909 0.9090909090909092 0.0442308086447979 0.736899002018673 0.3905649053317354 0.6926681933738751 0 0 0 0 K03151 0.6857142857142857 0.2621082621082621 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] path:map00730,path:map01100,path:map01240,path:map04122 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 74.0 398.0 381.0 5.0 0.929906542056075 H 336.0 92.0 2.0 0.957943925233645 COG0301 Adenylyl-_and_sulfurtransferase_ThiI_(thiamine_and_tRNA_4-thiouridine_biosynthesis) ThiI 428.0 0.7850467289719626 0.2149532710280373 0.7880294754667 0.883263753712285 0.8356466145894925 0.095234278245585 1 1 1 1 K03152 0.0714285714285714 0.2336182336182336 thiJ; protein deglycase [EC:3.5.1.124] 112.0 115.0 113.0 3.0 0.974576271186441 S 26.0 92.0 1.0 1.0 COG0693 Protein/nucleotide_deglycase,_PfpI/YajL/DJ-1_family_(repair_of_methylglyoxal-glycated_proteins_and_nucleic_acids) YajL 118.0 0.2203389830508474 0.7796610169491526 0.036193836941405 0.310920525246148 0.1735571810937765 0.274726688304743 0 0 0 0 K03153 0.0028571428571428 0.2706552706552707 thiO; glycine oxidase [EC:1.4.3.19] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 171.0 103.0 89.0 2.0 0.88034188034188 E 2.0 115.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 117.0 0.017094017094017 0.9829059829059827 0.0096752761119579 0.170905229093385 0.0902902526026714 0.1612299529814271 0 0 0 0 K03154 0.3485714285714286 0.5185185185185185 thiS; sulfur carrier protein path:map04122 Sulfur relay system 19.0 350.0 349.0 2.0 0.997150997150997 H 134.0 217.0 3.0 0.974358974358975 COG2104 Sulfur_carrier_protein_ThiS_(thiamine_biosynthesis) ThiS 351.0 0.3817663817663818 0.6182336182336182 0.0829894987367887 0.294364760129036 0.1886771294329123 0.2113752613922473 0 0 0 0 K03163 0.0828571428571428 0.0028490028490028 TOP1; DNA topoisomerase I [EC:5.6.2.1] 487.0 31.0 0.0 1.0 1.0 L 30.0 1.0 1.0 1.0 COG3569 DNA_topoisomerase_IB Top1 31.0 0.967741935483871 0.032258064516129 0.921885206299205 0.967452556242675 0.94466888127094 0.04556734994347 0 0 1 1 K03165 0.0085714285714285 0.0 TOP3; DNA topoisomerase III [EC:5.6.2.1] path:map03440,path:map03460 Homologous recombination,Fanconi anemia pathway 568.0 3.0 0.0 1.0 1.0 L 3.0 0.0 1.0 1.0 COG0550 DNA_topoisomerase_IA TopA 3.0 1.0 0.0 0 0 0 0 K03166 0.8285714285714286 0.017094017094017 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2] 261.0 311.0 0.0 1.0 1.0 L 305.0 6.0 2.0 0.996784565916399 COG1697 DNA_topoisomerase_VI,_subunit_A Spo11 311.0 0.9807073954983924 0.0192926045016077 0.687547639144232 0.225642025215329 0.4565948321797805 0.461905613928903 0 1 0 1 K03167 0.84 0.0142450142450142 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2] 343.0 321.0 320.0 2.0 0.996894409937888 L 317.0 5.0 3.0 0.987577639751553 COG1389 DNA_topoisomerase_VI,_subunit_B 322.0 0.984472049689441 0.015527950310559 0.645136102803391 0.599295476109523 0.6222157894564571 0.0458406266938679 0 1 0 1 K03168 0.88 0.9544159544159544 topA; DNA topoisomerase I [EC:5.6.2.1] 140.0 806.0 791.0 6.0 0.969915764139591 L 410.0 414.0 11.0 0.839951865222623 COG0550 DNA_topoisomerase_IA TopA 824.0 0.4975728155339806 0.5024271844660194 0.0466687954994511 0.006089164247604 0.0263789798735275 0.0405796312518471 0 0 0 0 K03169 0.1828571428571428 0.2649572649572649 topB; DNA topoisomerase III [EC:5.6.2.1] 259.0 191.0 184.0 3.0 0.959798994974874 L 69.0 130.0 6.0 0.964824120603015 COG0550 DNA_topoisomerase_IA TopA 199.0 0.3467336683417085 0.6532663316582915 0.346742285822946 0.858466629691434 0.60260445775719 0.511724343868488 0 0 0 0 K03170 0.2314285714285714 0.0398860398860398 topG, rgy; reverse gyrase [EC:5.6.2.2 5.6.2.-] 685.0 127.0 0.0 1.0 1.0 L 113.0 14.0 1.0 1.0 COG1110 Reverse_gyrase TopG2 127.0 0.889763779527559 0.1102362204724409 0.969086490511468 0.556998345624436 0.763042418067952 0.412088144887032 1 1 1 1 K03177 0.5028571428571429 0.9088319088319088 truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25] 95.0 526.0 523.0 3.0 0.988721804511278 J 204.0 327.0 2.0 0.994360902255639 COG0130 tRNA_U55_pseudouridine_synthase_TruB,_may_also_work_on_U342_of_tmRNA TruB 531.0 0.384180790960452 0.615819209039548 0.912777328915502 0.360181081700663 0.6364792053080826 0.552596247214839 1 1 1 1 K03179 0.2514285714285714 0.5584045584045584 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 113.0 330.0 328.0 3.0 0.990990990990991 H 98.0 235.0 2.0 0.993993993993994 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 333.0 0.2942942942942942 0.7057057057057057 0.0013151236139602 0.0869862274923497 0.0441506755531549 0.0856711038783895 0 0 0 0 K03181 0.02 0.1196581196581196 ubiC; chorismate lyase [EC:4.1.3.40] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 79.0 50.0 0.0 1.0 1.0 H 7.0 43.0 1.0 1.0 COG3161 4-hydroxybenzoate_synthetase_(chorismate-pyruvate_lyase) UbiC 50.0 0.14 0.86 0.0261837321562518 0.0207346365334194 0.0234591843448356 0.0054490956228324 0 0 0 0 K03182 0.3057142857142857 0.396011396011396 ubiD; 4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 241.0 292.0 0.0 1.0 1.0 H 130.0 162.0 1.0 1.0 COG0043 3-polyprenyl-4-hydroxybenzoate_decarboxylase UbiD 292.0 0.4452054794520548 0.5547945205479452 0.561158529341103 0.871122565977803 0.716140547659453 0.3099640366367 0 1 0 1 K03183 0.5428571428571428 0.7464387464387464 ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 17.0 305.0 15.0 6.0 0.489566613162119 Q 286.0 335.0 7.0 0.825040128410915 COG0500 SAM-dependent_methyltransferase SmtA 621.0 0.4605475040257649 0.5394524959742351 0.0084498799264111 0.0185772527240852 0.0135135663252481 0.0101273727976741 0 0 0 0 K03184 0.0 0.0398860398860398 ubiF; 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 364.0 12.0 9.0 2.0 0.8 CH 0.0 15.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 15.0 0.0 1.0 0.0103411510146848 2.96433910327223e-08 0.0051705903290379 0.0103411213712937 0 0 0 0 K03185 0.0 0.1994301994301994 ubiH; 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 253.0 83.0 81.0 2.0 0.976470588235294 CH 0.0 85.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 85.0 0.0 1.0 0.0036388225217381 0.0064107353762037 0.0050247789489709 0.0027719128544656 0 0 0 0 K03186 0.5228571428571429 0.4159544159544159 ubiX, bsdB, PAD1; flavin prenyltransferase [EC:2.5.1.129] path:map00130,path:map00627,path:map00740,path:map00900,path:map00940,path:map01100,path:map01110,path:map01120,path:map01220,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Aminobenzoate degradation,Riboflavin metabolism,Terpenoid backbone biosynthesis,Phenylpropanoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds,Biosynthesis of cofactors 120.0 341.0 330.0 2.0 0.96875 H 189.0 163.0 2.0 0.971590909090909 COG0163 Flavin_prenyltransferase_UbiX UbiX 352.0 0.5369318181818182 0.4630681818181818 0.263768722776773 0.719983972969339 0.491876347873056 0.456215250192566 0 0 0 0 K03187 0.0657142857142857 0.1452991452991453 ureE; urease accessory protein 93.0 72.0 70.0 2.0 0.972972972972973 O 23.0 51.0 3.0 0.675675675675676 COG2371 Urease_accessory_protein_UreE UreE 74.0 0.3108108108108108 0.6891891891891891 0.0088163623206604 0.0258621462215001 0.0173392542710802 0.0170457839008396 0 0 0 0 K03188 0.0685714285714285 0.1937321937321937 ureF; urease accessory protein 125.0 88.0 81.0 2.0 0.926315789473684 O 24.0 71.0 1.0 1.0 COG0830 Urease_accessory_protein_UreF UreF 95.0 0.2526315789473684 0.7473684210526316 0.002213377673364 0.0204226295426602 0.011318003608012 0.0182092518692962 0 0 0 0 K03189 0.1142857142857142 0.2193732193732193 ureG; urease accessory protein 162.0 77.0 39.0 4.0 0.626016260162602 KO 40.0 83.0 1.0 1.0 COG0378 Hydrogenase/urease_maturation_factor_HypB,_Ni2+-binding_GTPase HypB 123.0 0.3252032520325203 0.6747967479674797 0.0167088233597052 0.876480801527595 0.4465948124436501 0.8597719781678897 0 0 0 0 K03190 0.0714285714285714 0.188034188034188 ureD, ureH; urease accessory protein 134.0 86.0 78.0 2.0 0.914893617021277 O 25.0 69.0 1.0 1.0 COG0829 Urease_accessory_protein_UreH UreH 94.0 0.2659574468085106 0.7340425531914894 0.0132722463201022 0.0842055744495139 0.048738910384808 0.0709333281294117 0 0 0 0 K03191 0.0028571428571428 0.0142450142450142 ureI; acid-activated urea channel path:map05120 Epithelial cell signaling in Helicobacter pylori infection 163.0 5.0 4.0 2.0 0.833333333333333 S 1.0 5.0 1.0 1.0 29DTM 6.0 0.1666666666666666 0.8333333333333334 0.0771992819163077 0.19423322725069 0.1357162545834988 0.1170339453343823 0 0 0 0 K03192 0.0028571428571428 0.0769230769230769 ureJ; urease accessory protein 167.0 29.0 27.0 2.0 0.935483870967742 O 1.0 30.0 1.0 1.0 COG2370 Hydrogenase/urease_accessory_protein_HupE HupE 31.0 0.032258064516129 0.967741935483871 0.0232513017910925 0.0466890340522418 0.0349701679216671 0.0234377322611493 0 0 0 0 K03194 0.0 0.0199430199430199 virB1; type IV secretion system protein VirB1 path:map03070 Bacterial secretion system 151.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 8.0 0.0 1.0 0.0684450077234893 0.112590029084313 0.0905175184039011 0.0441450213608237 0 0 0 0 K03195 0.0 0.0598290598290598 virB10, lvhB10; type IV secretion system protein VirB10 path:map03070 Bacterial secretion system 186.0 35.0 0.0 1.0 1.0 U 0.0 35.0 1.0 1.0 COG2948 Type_IV_secretory_pathway,_VirB10_component VirB10 35.0 0.0 1.0 0.0123680926377757 0.0246037401938383 0.0184859164158069 0.0122356475560626 0 0 0 0 K03196 0.0 0.0455840455840455 virB11, lvhB11; type IV secretion system protein VirB11 [EC:7.4.2.8] path:map03070,path:map05120 Bacterial secretion system,Epithelial cell signaling in Helicobacter pylori infection 286.0 21.0 0.0 1.0 1.0 NU 0.0 21.0 1.0 1.0 COG0630 Type_IV_secretory_pathway_ATPase_VirB11/Archaellum_biosynthesis_ATPase_ArlI/FlaI VirB11 21.0 0.0 1.0 0.0263191355644014 0.0321300698800044 0.0292246027222029 0.0058109343156029 0 0 0 0 K03197 0.0 0.0398860398860398 virB2, lvhB2; type IV secretion system protein VirB2 path:map03070,path:map05134 Bacterial secretion system,Legionellosis 84.0 13.0 5.0 2.0 0.619047619047619 U 0.0 21.0 4.0 0.619047619047619 COG3838 Type_IV_secretory_pathway,_VirB2_component_(pilin) VirB2 21.0 0.0 1.0 0.0110172396734685 0.0178089202759542 0.0144130799747113 0.0067916806024857 0 0 0 0 K03198 0.0 0.0284900284900284 virB3, lvhB3; type IV secretion system protein VirB3 path:map03070 Bacterial secretion system 92.0 12.0 0.0 1.0 1.0 U 0.0 12.0 1.0 1.0 COG3702 Type_IV_secretory_pathway,_VirB3_component VirB3 12.0 0.0 1.0 0.0805164843993024 0.0714036151734242 0.0759600497863633 0.0091128692258782 0 0 0 0 K03199 0.0 0.0598290598290598 virB4, lvhB4; type IV secretion system protein VirB4 [EC:7.4.2.8] path:map03070 Bacterial secretion system 499.0 42.0 0.0 1.0 1.0 U 0.0 42.0 1.0 1.0 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 42.0 0.0 1.0 0.0021147072998557 0.0039425327830457 0.0030286200414506 0.0018278254831899 0 0 0 0 K03200 0.0 0.0512820512820512 virB5, lvhB5; type IV secretion system protein VirB5 path:map03070 Bacterial secretion system 108.0 20.0 14.0 3.0 0.666666666666667 U 0.0 30.0 6.0 0.4 COG3701 Type_IV_secretory_pathway,_TrbF_component TrbF 30.0 0.0 1.0 0.0201338931834056 0.0993542391660642 0.0597440661747349 0.0792203459826586 0 0 0 0 K03201 0.0028571428571428 0.0683760683760683 virB6, lvhB6; type IV secretion system protein VirB6 path:map03070 Bacterial secretion system 140.0 29.0 27.0 4.0 0.878787878787879 U 1.0 38.0 7.0 0.666666666666667 COG3704 Type_IV_secretory_pathway,_VirB6_component VirB6 39.0 0.0256410256410256 0.9743589743589745 0.0043988328656203 0.0072675318922001 0.0058331823789102 0.0028686990265797 0 0 0 0 K03203 0.0 0.0512820512820512 virB8, lvhB8; type IV secretion system protein VirB8 path:map03070 Bacterial secretion system 165.0 22.0 18.0 2.0 0.846153846153846 U 0.0 26.0 2.0 0.846153846153846 COG3736 Type_IV_secretory_pathway,_component_VirB8 VirB8 26.0 0.0 1.0 0.0430078229935634 0.0506080714194886 0.046807947206526 0.0076002484259252 0 0 0 0 K03204 0.0 0.0512820512820512 virB9, lvhB9; type IV secretion system protein VirB9 path:map03070 Bacterial secretion system 163.0 33.0 0.0 1.0 1.0 U 0.0 33.0 1.0 1.0 COG3504 Type_IV_secretory_pathway,_VirB9_components VirB9 33.0 0.0 1.0 0.0052558268155099 0.0107413767940028 0.0079986018047563 0.0054855499784929 0 0 0 0 K03205 0.0057142857142857 0.1794871794871795 virD4, lvhD4; type IV secretion system protein VirD4 [EC:7.4.2.8] path:map03070 Bacterial secretion system 147.0 146.0 139.0 2.0 0.954248366013072 U 2.0 139.0 2.0 0.954248366013072 COG3505 Type_IV_secretory_pathway,_VirD4_component,_TraG/TraD_family_ATPase VirD4 141.0 0.0141843971631205 0.9858156028368794 0.0132491184640932 0.211104980028853 0.1121770492464731 0.1978558615647598 0 0 0 0 K03206 0.0 0.0085470085470085 azr; azobenzene reductase [EC:1.7.1.6] 161.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 4.0 0.0 1.0 2.16064682974004e-06 0.0014395290744964 0.000720844860663 0.0014373684276666 0 0 0 0 K03207 0.06 0.0455840455840455 gmm, nudD, wcaH; GDP-mannose mannosyl hydrolase [EC:3.6.1.-] 52.0 27.0 16.0 3.0 0.692307692307692 F 23.0 16.0 3.0 0.948717948717949 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 39.0 0.5897435897435898 0.4102564102564102 0.140855285381869 0.424207216466435 0.282531250924152 0.283351931084566 0 0 0 0 K03208 0.0 0.074074074074074 wcaI; putative colanic acid biosynthesis glycosyltransferase WcaI path:map00543 Exopolysaccharide biosynthesis 344.0 30.0 28.0 2.0 0.9375 M 0.0 32.0 2.0 0.9375 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 32.0 0.0 1.0 0.0402697786075463 0.0770368521426495 0.0586533153750979 0.0367670735351032 0 0 0 0 K03210 0.0 0.7521367521367521 yajC; preprotein translocase subunit YajC path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 45.0 265.0 0.0 1.0 1.0 U 0.0 265.0 1.0 1.0 COG1862 Protein_translocase_subunit_YajC YajC 265.0 0.0 1.0 0.30456463604981 0.352621720233425 0.3285931781416175 0.0480570841836149 0 0 0 0 K03212 0.0171428571428571 0.0313390313390313 rumB; 23S rRNA (uracil747-C5)-methyltransferase [EC:2.1.1.189] 337.0 16.0 15.0 2.0 0.941176470588235 J 6.0 11.0 1.0 1.0 COG2265 tRNA/tmRNA/rRNA_uracil-C5-methylase,_TrmA/RlmC/RlmD_family TrmA 17.0 0.3529411764705882 0.6470588235294118 0.0208924150938953 0.0460129765740586 0.0334526958339769 0.0251205614801633 0 0 0 0 K03214 0.0 0.0341880341880341 yfiF, trmG; RNA methyltransferase, TrmH family [EC:2.1.1.-] 233.0 12.0 0.0 1.0 1.0 J 0.0 12.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 12.0 0.0 1.0 0.407942706248563 0.199399831961678 0.3036712691051205 0.208542874286885 0 0 0 0 K03215 0.0371428571428571 0.8205128205128205 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] 64.0 321.0 285.0 3.0 0.874659400544959 J 14.0 353.0 4.0 0.956403269754768 COG2265 tRNA/tmRNA/rRNA_uracil-C5-methylase,_TrmA/RlmC/RlmD_family TrmA 367.0 0.0381471389645776 0.9618528610354224 0.216224644936339 0.212264363469046 0.2142445042026925 0.0039602814672929 0 0 0 0 K03216 0.0085714285714285 0.5270655270655271 trmL, cspR; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207] 103.0 188.0 185.0 2.0 0.984293193717278 J 3.0 188.0 2.0 0.984293193717278 COG0219 tRNA(Leu)_C34_or_U34_(ribose-2'-O)-methylase_TrmL,_contains_SPOUT_domain TrmL 191.0 0.0157068062827225 0.9842931937172776 0.0067788433907926 0.0237851088611619 0.0152819761259772 0.0170062654703693 0 0 0 0 K03217 0.0028571428571428 0.9857549857549858 yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 75.0 370.0 359.0 7.0 0.958549222797927 U 1.0 383.0 7.0 0.963730569948186 COG0706 Membrane_protein_insertase_Oxa1/YidC/SpoIIIJ YidC 384.0 0.0026041666666666 0.9973958333333334 0.30346111261773 0.705564524541892 0.504512818579811 0.402103411924162 0 0 0 0 K03218 0.0485714285714285 0.8490028490028491 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185] 113.0 355.0 343.0 2.0 0.967302452316076 J 18.0 349.0 2.0 0.983651226158038 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 367.0 0.0490463215258855 0.9509536784741144 0.741488677543226 0.385697441266374 0.5635930594048 0.355791236276852 0 1 0 1 K03219 0.0 0.0512820512820512 yscC, sctC, ssaC; type III secretion protein C path:map03070 Bacterial secretion system 255.0 26.0 25.0 2.0 0.962962962962963 NU 0.0 27.0 2.0 0.962962962962963 COG1450 Type_II_secretory_pathway_component_GspD/PulD_(secretin) PulD 27.0 0.0 1.0 0.0861844303031033 0.0576857714206465 0.0719351008618749 0.0284986588824567 0 0 0 0 K03220 0.0 0.0256410256410256 yscD, sctD, ssaD; type III secretion protein D 93.0 7.0 6.0 3.0 0.777777777777778 T 0.0 9.0 3.0 0.777777777777778 COG1716 Forkhead_associated_(FHA)_domain,_binds_pSer,_pThr,_pTyr FHA 9.0 0.0 1.0 0.0254969291945903 0.0741054731148791 0.0498012011547347 0.0486085439202887 0 0 0 0 K03221 0.0 0.0056980056980056 yscF, sctF, ssaG, prgI; type III secretion protein F path:map03070,path:map05130,path:map05131,path:map05132 Bacterial secretion system,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection 52.0 3.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 2BWZD 3.0 0.0 1.0 0 0 0 0 K03222 0.0 0.0227920227920227 yscJ, sctJ, hrcJ, ssaJ; type III secretion protein J path:map03070 Bacterial secretion system 239.0 9.0 8.0 2.0 0.9 U 0.0 10.0 1.0 1.0 COG4669 Type_III_secretory_pathway,_lipoprotein_EscJ EscJ 10.0 0.0 1.0 0.0535266547408975 0.0867386493183172 0.0701326520296073 0.0332119945774197 0 0 0 0 K03223 0.0 0.074074074074074 yscL, sctL; type III secretion protein L path:map03070 Bacterial secretion system 119.0 20.0 14.0 3.0 0.740740740740741 N 0.0 27.0 1.0 1.0 COG1317 Flagellar_biosynthesis/type_III_secretory_pathway_protein_FliH FliH 27.0 0.0 1.0 0.384990510327339 0.0880021907329133 0.2364963505301261 0.2969883195944257 0 0 0 0 K03224 0.0 0.131054131054131 yscN, sctN, hrcN, ssaN; ATP synthase in type III secretion protein N [EC:7.4.2.8] path:map03070 Bacterial secretion system 389.0 48.0 47.0 2.0 0.979591836734694 NU 0.0 49.0 1.0 1.0 COG1157 Flagellar_biosynthesis/type_III_secretory_pathway_ATPase_FliI FliI 49.0 0.0 1.0 0.169356206114768 0.694195976691176 0.431776091402972 0.5248397705764081 0 0 0 0 K03225 0.0 0.0341880341880341 yscQ, sctQ, hrcQ, ssaQ, spaO; type III secretion protein Q path:map03070 Bacterial secretion system 97.0 9.0 2.0 2.0 0.5625 NU 0.0 16.0 2.0 0.8125 COG1886 Flagellar_motor_switch/type_III_secretory_pathway_protein_FliN FliN 16.0 0.0 1.0 0.0323672121346865 0.0520909940162801 0.0422291030754833 0.0197237818815936 0 0 0 0 K03226 0.0 0.0512820512820512 yscR, sctR, hrcR, ssaR; type III secretion protein R path:map03070 Bacterial secretion system 189.0 12.0 3.0 2.0 0.571428571428571 U 0.0 21.0 2.0 0.571428571428571 COG4790 Type_III_secretory_pathway,_EscR/YscR_component EscR 21.0 0.0 1.0 0.0357863662330557 0.264813452566371 0.1502999093997133 0.2290270863333153 0 0 0 0 K03227 0.0 0.0712250712250712 yscS, sctS, hrcS, ssaS; type III secretion protein S path:map03070 Bacterial secretion system 87.0 21.0 17.0 2.0 0.84 N 0.0 25.0 2.0 0.84 COG1987 Flagellar_biosynthesis_protein_FliQ FliQ 25.0 0.0 1.0 0.0417513014009877 0.0378809216232983 0.0398161115121429 0.0038703797776893 0 0 0 0 K03228 0.0 0.0484330484330484 yscT, sctT, hrcT, ssaT; type III secretion protein T path:map03070 Bacterial secretion system 202.0 11.0 2.0 2.0 0.55 U 0.0 20.0 2.0 0.55 COG4791 Type_III_secretory_pathway,_EscT/YscT_component EscT 20.0 0.0 1.0 0.164103161179915 0.229537636987005 0.19682039908346 0.06543447580709 0 0 0 0 K03229 0.0 0.037037037037037 yscU, sctU, hrcU, ssaU; type III secretion protein U path:map03070 Bacterial secretion system 326.0 8.0 3.0 3.0 0.5 N 0.0 16.0 2.0 0.9375 COG1377 Flagellar_biosynthesis_protein_FlhB FlhB 16.0 0.0 1.0 0.0372351793884798 0.0838008263595518 0.0605180028740158 0.046565646971072 0 0 0 0 K03230 0.0 0.0256410256410256 yscV, sctV, hrcV, ssaV, invA; type III secretion protein V path:map03070 Bacterial secretion system 650.0 12.0 0.0 1.0 1.0 U 0.0 12.0 1.0 1.0 COG4789 Type_III_secretory_pathway,_component_EscV EscV 12.0 0.0 1.0 0.0411164918491384 0.0728174524630157 0.056966972156077 0.0317009606138773 0 0 0 0 K03231 0.9371428571428572 0.0 EEF1A; elongation factor 1-alpha path:map03013,path:map05134,path:map05140 Nucleocytoplasmic transport,Legionellosis,Leishmaniasis 324.0 437.0 0.0 1.0 1.0 J 437.0 0.0 2.0 0.803203661327231 COG5256 Translation_elongation_factor_EF-1alpha_(GTPase) TEF1 437.0 1.0 0.0 0.990833493731538 0.789535160581467 0.8901843271565024 0.2012983331500709 0 0 1 1 K03232 0.8228571428571428 0.0 EEF1B; elongation factor 1-beta 59.0 290.0 0.0 1.0 1.0 J 290.0 0.0 1.0 1.0 COG2092 Translation_elongation_factor_EF-1beta EFB1 290.0 1.0 0.0 0.798547748084628 0.671780627729997 0.7351641879073125 0.126767120354631 0 0 1 1 K03234 0.94 0.0 EEF2; elongation factor 2 path:map04152,path:map04921 AMPK signaling pathway,Oxytocin signaling pathway 608.0 352.0 0.0 1.0 1.0 J 352.0 0.0 1.0 1.0 COG0480 Translation_elongation_factor_EF-G,_a_GTPase FusA 352.0 1.0 0.0 0.993520291467652 0.985555878487082 0.989538084977367 0.0079644129805699 0 0 1 1 K03236 0.9342857142857144 0.0 EIF1A; translation initiation factor 1A 64.0 401.0 0.0 1.0 1.0 J 401.0 0.0 1.0 1.0 COG0361 Translation_initiation_factor_IF-1 InfA 401.0 1.0 0.0 0.976869130917007 0.94576693549716 0.9613180332070834 0.031102195419847 0 0 1 1 K03237 0.9171428571428571 0.0 EIF2S1; translation initiation factor 2 subunit 1 path:map04138,path:map04140,path:map04141,path:map04210,path:map04932,path:map05010,path:map05012,path:map05014,path:map05020,path:map05022,path:map05160,path:map05162,path:map05164,path:map05168,path:map05417 Autophagy - yeast,Autophagy - animal,Protein processing in endoplasmic reticulum,Apoptosis,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Prion disease,Pathways of neurodegeneration - multiple diseases,Hepatitis C,Measles,Influenza A,Herpes simplex virus 1 infection,Lipid and atherosclerosis 164.0 323.0 0.0 1.0 1.0 J 323.0 0.0 1.0 1.0 COG1093 Translation_initiation_factor_2,_alpha_subunit_(eIF-2alpha) SUI2 323.0 1.0 0.0 0.980180621730402 0.865602073321372 0.922891347525887 0.11457854840903 0 0 1 1 K03238 0.9342857142857144 0.0 EIF2S2; translation initiation factor 2 subunit 2 90.0 349.0 0.0 1.0 1.0 J 349.0 0.0 2.0 0.988538681948424 COG1601 Translation_initiation_factor_2,_beta_subunit_(eIF-2beta)/eIF-5_N-terminal_domain GCD7 349.0 1.0 0.0 0.366512234743075 0.11994475983214 0.2432284972876074 0.246567474910935 0 0 0 0 K03239 0.2657142857142857 0.0227920227920227 EIF2B1; translation initiation factor eIF-2B subunit alpha path:map05168 Herpes simplex virus 1 infection 278.0 104.0 0.0 1.0 1.0 J 96.0 8.0 2.0 0.942307692307692 COG0182 5-methylthioribose/5-deoxyribulose_1-phosphate_isomerase_(methionine_salvage_pathway),_a_paralog_of_eIF-2B_alpha_subunit MtnA 104.0 0.9230769230769232 0.0769230769230769 0.957562993704008 0.963129013658342 0.9603460036811752 0.005566019954334 1 1 1 1 K03242 0.9114285714285716 0.0 EIF2S3; translation initiation factor 2 subunit 3 339.0 327.0 0.0 1.0 1.0 J 327.0 0.0 1.0 1.0 COG3276 Selenocysteine-specific_translation_elongation_factor_SelB SelB 327.0 1.0 0.0 0.925665911329535 0.225089817050453 0.575377864189994 0.700576094279082 0 0 1 1 K03243 0.9028571428571428 0.0 EIF5B; translation initiation factor 5B 397.0 344.0 340.0 2.0 0.988505747126437 J 348.0 0.0 5.0 0.968390804597701 COG0532 Translation_initiation_factor_IF-2,_a_GTPase InfB 348.0 1.0 0.0 0.154995088228917 0.794271511353106 0.4746332997910115 0.639276423124189 0 0 0 0 K03263 0.9342857142857144 0.0 EIF5A; translation initiation factor 5A 99.0 331.0 0.0 1.0 1.0 J 331.0 0.0 1.0 1.0 COG0231 Translation_elongation_factor_P_(EF-P)/translation_initiation_factor_5A_(eIF-5A) Efp 331.0 1.0 0.0 0.91882369424569 0.707067154555896 0.812945424400793 0.211756539689794 0 0 1 1 K03264 0.8171428571428572 0.0 EIF6; translation initiation factor 6 path:map03008 Ribosome biogenesis in eukaryotes 144.0 287.0 0.0 1.0 1.0 J 287.0 0.0 1.0 1.0 COG1976 Translation_initiation_factor_6_(eIF-6) TIF6 287.0 1.0 0.0 0.945159116268847 0.838547159439198 0.8918531378540224 0.1066119568296489 0 0 1 1 K03265 0.8742857142857143 0.0911680911680911 ETF1, ERF1; peptide chain release factor subunit 1 path:map03015 mRNA surveillance pathway 258.0 356.0 0.0 1.0 1.0 J 322.0 34.0 1.0 1.0 COG1503 Peptide_chain_release_factor_1_(eRF1) eRF1 356.0 0.904494382022472 0.095505617977528 0.995850747074352 0.993600365972505 0.9947255565234284 0.0022503811018469 1 1 1 1 K03268 0.0 0.0085470085470085 todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26] path:map00361,path:map00362,path:map00623,path:map00625,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 390.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 4.0 0.0 1.0 6.31636443875678e-12 0.114014864481347 0.0570074322438316 0.1140148644750306 0 0 0 0 K03269 0.0 0.2706552706552707 lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 100.0 84.0 73.0 2.0 0.884210526315789 S 0.0 95.0 1.0 1.0 COG2908 UDP-2,3-diacylglucosamine_pyrophosphatase_LpxH LpxH 95.0 0.0 1.0 0.0040943319779367 0.0146459330771447 0.0093701325275407 0.010551601099208 0 0 0 0 K03270 0.0085714285714285 0.4159544159544159 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 98.0 147.0 136.0 4.0 0.890909090909091 S 3.0 161.0 2.0 0.939393939393939 COG1778 3-deoxy-D-manno-octulosonate_8-phosphate_phosphatase_KdsC_and_related_HAD_superfamily_phosphatases KdsC 164.0 0.0182926829268292 0.9817073170731708 0.0039133255074944 0.0419456031768256 0.02292946434216 0.0380322776693312 0 0 0 0 K03271 0.12 0.5299145299145299 gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 89.0 284.0 277.0 8.0 0.946666666666667 G 49.0 251.0 3.0 0.953333333333333 COG0279 Phosphoheptose_isomerase GmhA 300.0 0.1633333333333333 0.8366666666666667 0.427019420996423 0.206834414014086 0.3169269175052545 0.2201850069823369 0 0 0 0 K03272 0.0685714285714285 0.3817663817663818 gmhC, hldE, waaE, rfaE; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 139.0 117.0 74.0 5.0 0.576354679802956 H 24.0 156.0 4.0 0.605911330049261 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 180.0 0.1333333333333333 0.8666666666666667 0.826751007979628 0.677244569742182 0.751997788860905 0.149506438237446 1 1 1 1 K03273 0.14 0.4301994301994302 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 66.0 199.0 188.0 7.0 0.884444444444445 E 51.0 173.0 3.0 0.968888888888889 COG0241 Histidinol_phosphatase/D-glycero-mannoheptose_bisphosphatephosphatase,_HAD_superfamily HisB1/GmhB 224.0 0.2276785714285714 0.7723214285714286 0.599881421239173 0.645503817241358 0.6226926192402655 0.0456223960021849 0 1 0 1 K03274 0.14 0.2535612535612536 gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 185.0 73.0 14.0 5.0 0.496598639455782 M 54.0 93.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 147.0 0.3673469387755102 0.6326530612244898 0.727307383477682 0.803298261399063 0.7653028224383724 0.075990877921381 0 1 0 1 K03275 0.0 0.0056980056980056 waaO, rfaI; UDP-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase [EC:2.4.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 60.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG1442 Lipopolysaccharide_biosynthesis_protein,_LPS:glycosyltransferase RfaJ 2.0 0.0 1.0 0 0 0 0 K03276 0.0 0.0056980056980056 waaR, waaT, rfaJ; UDP-glucose/galactose:(glucosyl)LPS alpha-1,2-glucosyl/galactosyltransferase [EC:2.4.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 42.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1442 Lipopolysaccharide_biosynthesis_protein,_LPS:glycosyltransferase RfaJ 3.0 0.0 1.0 0 0 0 0 K03277 0.0 0.0085470085470085 waaU, rfaK; heptosyltransferase IV [EC:2.4.-.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 135.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG0859 ADP-heptose:LPS_heptosyltransferase RfaF 3.0 0.0 1.0 0 0 0 0 K03278 0.0 0.0056980056980056 waaI, rfaI; UDP-D-galactose:(glucosyl)LPS alpha-1,3-D-galactosyltransferase [EC:2.4.1.44] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 60.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG1442 Lipopolysaccharide_biosynthesis_protein,_LPS:glycosyltransferase RfaJ 2.0 0.0 1.0 0 0 0 0 K03279 0.0 0.0056980056980056 waaJ, rfaJ; UDP-glucose:(galactosyl)LPS alpha-1,2-glucosyltransferase [EC:2.4.1.58] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 42.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1442 Lipopolysaccharide_biosynthesis_protein,_LPS:glycosyltransferase RfaJ 3.0 0.0 1.0 0 0 0 0 K03280 0.0 0.0028490028490028 waaK, rfaK; UDP-N-acetylglucosamine:(glucosyl)LPS alpha-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.56] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 422.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K03281 0.3228571428571428 0.4786324786324786 TC.CIC; chloride channel protein, CIC family 129.0 334.0 321.0 7.0 0.863049095607235 P 143.0 239.0 11.0 0.901808785529716 COG0038 H+/Cl-_antiporter_ClcA ClcA 382.0 0.3743455497382199 0.6256544502617801 0.750354200462165 0.517760334828899 0.634057267645532 0.232593865633266 1 1 1 1 K03282 0.1371428571428571 0.5014245014245015 mscL; large conductance mechanosensitive channel 64.0 231.0 227.0 3.0 0.974683544303797 M 49.0 188.0 1.0 1.0 COG1970 Large-conductance_mechanosensitive_channel MscL 237.0 0.2067510548523206 0.7932489451476793 0.51926607236436 0.92443211862521 0.7218490954947849 0.40516604626085 0 1 0 1 K03284 0.4 0.6666666666666666 corA; magnesium transporter 57.0 494.0 0.0 1.0 1.0 P 176.0 317.0 2.0 0.993927125506073 COG0598 Mg2+_and_Co2+_transporter_CorA CorA 493.0 0.356997971602434 0.6430020283975659 0.139631894245545 0.562314175093452 0.3509730346694985 0.422682280847907 0 0 0 0 K03285 0.0 0.0113960113960113 TC.GBP; general bacterial porin, GBP family 270.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 7.0 0.0 1.0 0.0042762988234453 0.0076726248075054 0.0059744618154753 0.00339632598406 0 0 0 0 K03286 0.0085714285714285 0.3276353276353276 TC.OOP; OmpA-OmpF porin, OOP family 10.0 220.0 218.0 3.0 0.986547085201794 M 3.0 219.0 9.0 0.803571428571429 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 222.0 0.0135135135135135 0.9864864864864864 0.0178685526547634 0.0438325233359077 0.0308505379953355 0.0259639706811443 0 0 0 0 K03287 0.0 0.0826210826210826 TC.OMF; outer membrane factor, OMF family 304.0 31.0 0.0 1.0 1.0 MU 0.0 31.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 31.0 0.0 1.0 0.0489879198351652 0.462591391952946 0.2557896558940556 0.4136034721177808 0 0 0 0 K03288 0.0 0.0113960113960113 citA, tcuC; MFS transporter, MHS family, citrate/tricarballylate:H+ symporter 106.0 5.0 0.0 1.0 1.0 EGP 0.0 5.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 5.0 0.0 1.0 0 0 0 0 K03289 0.0 0.0341880341880341 nupG; MFS transporter, NHS family, nucleoside permease 389.0 14.0 0.0 1.0 1.0 G 0.0 14.0 1.0 1.0 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 14.0 0.0 1.0 0.0205182040746472 0.0275902057992529 0.02405420493695 0.0070720017246057 0 0 0 0 K03290 0.0 0.0284900284900284 nanT; MFS transporter, SHS family, sialic acid transporter 428.0 11.0 0.0 1.0 1.0 EGP 0.0 11.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 11.0 0.0 1.0 0 0 0 0 K03291 0.0 0.0313390313390313 MFS.SET; MFS transporter, SET family, sugar efflux transporter 364.0 11.0 7.0 2.0 0.733333333333333 EGP 0.0 15.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 15.0 0.0 1.0 0 0 0 0 K03292 0.0514285714285714 0.225071225071225 TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family 192.0 238.0 235.0 3.0 0.983471074380165 G 106.0 136.0 3.0 0.991735537190083 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 242.0 0.4380165289256198 0.5619834710743802 0.0064181731313451 0.0867054737249435 0.0465618234281443 0.0802873005935984 0 0 0 0 K03293 0.0257142857142857 0.1424501424501424 TC.AAT; amino acid transporter, AAT family 324.0 95.0 94.0 2.0 0.989583333333333 E 9.0 96.0 6.0 0.761904761904762 COG1113 L-asparagine_transporter_or_related_permease AnsP 105.0 0.0857142857142857 0.9142857142857144 0.0167468787195219 0.106371233945985 0.0615590563327534 0.089624355226463 0 0 0 0 K03294 0.3742857142857143 0.4358974358974359 TC.APA; basic amino acid/polyamine antiporter, APA family 146.0 474.0 432.0 3.0 0.916827852998066 E 206.0 311.0 4.0 0.899419729206963 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 517.0 0.3984526112185687 0.6015473887814313 0.730343276942443 0.961658835411777 0.8460010561771101 0.2313155584693339 0 1 0 1 K03296 0.0 0.6125356125356125 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family 439.0 498.0 480.0 4.0 0.957692307692308 V 0.0 520.0 2.0 0.996153846153846 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 520.0 0.0 1.0 0.129804937872721 0.880551078978336 0.5051780084255285 0.750746141105615 0 0 0 0 K03297 0.1114285714285714 0.1994301994301994 emrE, qac, mmr, smr; small multidrug resistance pump 99.0 104.0 77.0 2.0 0.793893129770992 P 45.0 86.0 2.0 0.99236641221374 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 131.0 0.3435114503816794 0.6564885496183206 0.134924083865007 0.122705069913036 0.1288145768890215 0.012219013951971 0 0 0 0 K03298 0.1628571428571428 0.150997150997151 TC.DME; drug/metabolite transporter, DME family 190.0 80.0 30.0 2.0 0.615384615384615 EG 70.0 60.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 130.0 0.5384615384615384 0.4615384615384615 0.765307361496228 0.93355091753569 0.849429139515959 0.1682435560394619 1 1 1 1 K03299 0.0828571428571428 0.1994301994301994 TC.GNTP; gluconate:H+ symporter, GntP family 340.0 96.0 60.0 4.0 0.690647482014388 EG 38.0 101.0 2.0 0.971223021582734 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 139.0 0.2733812949640288 0.7266187050359713 0.168385496443863 0.113017015728777 0.14070125608632 0.055368480715086 0 0 0 0 K03300 0.0028571428571428 0.0484330484330484 TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family 401.0 21.0 19.0 2.0 0.91304347826087 C 1.0 22.0 3.0 0.91304347826087 COG2851 Mg2+/citrate_symporter CitM 23.0 0.0434782608695652 0.9565217391304348 0.0657167343938175 0.122941043000569 0.0943288886971932 0.0572243086067515 0 0 0 0 K03301 0.0028571428571428 0.1054131054131054 TC.AAA; ATP:ADP antiporter, AAA family 198.0 47.0 40.0 4.0 0.839285714285714 C 1.0 55.0 4.0 0.75 COG3202 ATP/ADP_translocase TlcC 56.0 0.0178571428571428 0.9821428571428572 0.0149793520382883 0.0156116846104671 0.0152955183243777 0.0006323325721788 0 0 0 0 K03303 0.1571428571428571 0.2507122507122507 lctP; lactate permease 325.0 180.0 175.0 4.0 0.957446808510638 C 73.0 115.0 3.0 0.962765957446808 COG1620 L-lactate_permease LldP 188.0 0.3882978723404255 0.6117021276595744 0.168056063415782 0.901310566650707 0.5346833150332445 0.7332545032349249 0 0 0 0 K03304 0.0057142857142857 0.0655270655270655 tehA; tellurite resistance protein 283.0 26.0 0.0 1.0 1.0 P 2.0 24.0 1.0 1.0 COG1275 Tellurite_resistance_protein_TehA_and_related_permeases TehA 26.0 0.0769230769230769 0.9230769230769232 0.0198634375546838 0.0694399007999703 0.044651669177327 0.0495764632452865 0 0 0 0 K03305 0.0085714285714285 0.2193732193732193 TC.POT; proton-dependent oligopeptide transporter, POT family 306.0 97.0 83.0 4.0 0.763779527559055 E 4.0 123.0 2.0 0.984251968503937 COG3104 Dipeptide/tripeptide_permease PTR2 127.0 0.0314960629921259 0.968503937007874 0.0002472413416074 0.0121878143597914 0.0062175278506994 0.0119405730181839 0 0 0 0 K03306 0.5457142857142857 0.4757834757834758 TC.PIT; inorganic phosphate transporter, PiT family 192.0 545.0 532.0 2.0 0.976702508960573 P 346.0 212.0 1.0 1.0 COG0306 Phosphate/sulfate_permease PitA 558.0 0.6200716845878136 0.3799283154121863 0.98010471314686 0.988916228262002 0.984510470704431 0.0088115151151419 1 1 1 1 K03307 0.4314285714285714 0.4586894586894587 TC.SSS; solute:Na+ symporter, SSS family 85.0 595.0 510.0 4.0 0.846372688477952 E 278.0 421.0 4.0 0.864864864864865 COG0591 Na+/proline_symporter PutP 699.0 0.3977110157367668 0.6022889842632332 0.0497453433731284 0.13015953004523 0.0899524367091792 0.0804141866721016 0 0 0 0 K03308 0.2542857142857143 0.3304843304843304 TC.NSS; neurotransmitter:Na+ symporter, NSS family 283.0 182.0 34.0 3.0 0.538461538461538 S 146.0 192.0 1.0 1.0 COG0733 Na+-dependent_transporter,_SNF_family YocR 338.0 0.4319526627218935 0.5680473372781065 0.0171842092599269 0.558263813582399 0.2877240114211629 0.541079604322472 0 0 0 0 K03309 0.0 0.1452991452991453 TC.DAACS; dicarboxylate/amino acid:cation (Na+ or H+) symporter, DAACS family 341.0 35.0 10.0 2.0 0.583333333333333 U 0.0 60.0 1.0 1.0 COG1301 Na+/H+-dicarboxylate_symporter GltP 60.0 0.0 1.0 0.128833678381563 0.648004140687141 0.388418909534352 0.519170462305578 0 0 0 0 K03310 0.0714285714285714 0.4415954415954416 TC.AGCS; alanine or glycine:cation symporter, AGCS family 321.0 236.0 182.0 4.0 0.784053156146179 E 29.0 272.0 2.0 0.970099667774086 COG1115 Na+/alanine_symporter AlsT 301.0 0.0963455149501661 0.903654485049834 0.048981203717241 0.736080908604745 0.392531056160993 0.6870997048875039 0 0 0 0 K03311 0.0 0.1396011396011396 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family 320.0 41.0 17.0 3.0 0.577464788732394 E 0.0 71.0 1.0 1.0 COG1114 Branched-chain_amino_acid_permease BrnQ 71.0 0.0 1.0 0.0030857377457323 0.069965385257429 0.0365255615015806 0.0668796475116967 0 0 0 0 K03312 0.0228571428571428 0.1794871794871795 gltS; glutamate:Na+ symporter, ESS family 270.0 56.0 13.0 3.0 0.56 E 11.0 89.0 1.0 1.0 COG0786 Na+/glutamate_symporter GltS 100.0 0.11 0.89 0.0476829965437525 0.216943787440872 0.1323133919923122 0.1692607908971195 0 0 0 0 K03313 0.0114285714285714 0.2849002849002849 nhaA; Na+:H+ antiporter, NhaA family 283.0 133.0 131.0 2.0 0.985185185185185 P 5.0 130.0 2.0 0.962962962962963 COG3004 Na+/H+_antiporter_NhaA NhaA 135.0 0.037037037037037 0.9629629629629628 0.0366596190223815 0.670759361722814 0.3537094903725977 0.6340997427004326 0 0 0 0 K03314 0.0 0.0398860398860398 nhaB; Na+:H+ antiporter, NhaB family 490.0 15.0 0.0 1.0 1.0 P 0.0 15.0 1.0 1.0 COG3067 Na+/H+_antiporter_NhaB NhaB 15.0 0.0 1.0 0.0106574811870858 0.0238756158493107 0.0172665485181982 0.0132181346622249 0 0 0 0 K03315 0.0857142857142857 0.1595441595441595 nhaC; Na+:H+ antiporter, NhaC family 371.0 145.0 141.0 2.0 0.973154362416107 C 49.0 100.0 1.0 1.0 COG1757 Na+/H+_antiporter_NhaC/MleN NhaC 149.0 0.3288590604026846 0.6711409395973155 0.0125607451302111 0.0534946330107333 0.0330276890704722 0.0409338878805222 0 0 0 0 K03316 0.0657142857142857 0.2934472934472934 TC.CPA1; monovalent cation:H+ antiporter, CPA1 family 240.0 169.0 164.0 4.0 0.933701657458564 P 24.0 157.0 7.0 0.864130434782609 COG0025 NhaP-type_Na+/H+_or_K+/H+_antiporter NhaP 181.0 0.1325966850828729 0.8674033149171271 0.728984395929743 0.710257529303072 0.7196209626164074 0.018726866626671 0 1 0 1 K03317 0.0 0.225071225071225 TC.CNT; concentrative nucleoside transporter, CNT family 345.0 80.0 70.0 3.0 0.851063829787234 F 0.0 94.0 1.0 1.0 COG1972 Nucleoside_permease_NupC NupC 94.0 0.0 1.0 0.0217086520445863 0.542501658719165 0.2821051553818756 0.5207930066745787 0 0 0 0 K03318 0.0 0.0028490028490028 tutB; tyrosine permease 422.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 1.0 0.0 1.0 0 0 0 0 K03319 0.02 0.0712250712250712 TC.DASS; divalent anion:Na+ symporter, DASS family 403.0 41.0 0.0 1.0 1.0 P 7.0 34.0 2.0 0.951219512195122 COG0471 Di-_and_tricarboxylate_antiporter CitT 41.0 0.1707317073170731 0.8292682926829268 0.0597039769654089 0.0709070922724968 0.0653055346189528 0.0112031153070878 0 0 0 0 K03320 0.4085714285714286 0.6752136752136753 amt, AMT, MEP; ammonium transporter, Amt family 212.0 527.0 479.0 6.0 0.839171974522293 P 205.0 420.0 14.0 0.930047694753577 COG0004 Ammonia_channel_protein_AmtB AmtB 625.0 0.328 0.672 0.060491289532947 0.331313260723456 0.1959022751282015 0.270821971190509 0 0 0 0 K03321 0.0285714285714285 0.5213675213675214 TC.SULP; sulfate permease, SulP family 284.0 349.0 325.0 5.0 0.911227154046997 P 12.0 371.0 7.0 0.903394255874674 COG0659 Sulfate_permease_or_related_transporter,_MFS_superfamily SUL1 383.0 0.031331592689295 0.9686684073107048 0.0328593843702472 0.820419077420449 0.426639230895348 0.7875596930502018 0 0 0 0 K03322 0.1085714285714285 0.2393162393162393 mntH; manganese transport protein 309.0 131.0 118.0 3.0 0.867549668874172 P 55.0 96.0 6.0 0.754966887417219 COG1914 Mn2+_or_Fe2+_transporter,_NRAMP_family MntH 151.0 0.3642384105960264 0.6357615894039735 0.81826297779546 0.845399637541439 0.8318313076684495 0.027136659745979 1 1 1 1 K03324 0.0428571428571428 0.3846153846153846 yjbB; phosphate:Na+ symporter 272.0 191.0 0.0 1.0 1.0 P 16.0 175.0 1.0 1.0 COG1283 Na+/phosphate_symporter NptA 191.0 0.0837696335078534 0.9162303664921466 0.980766227588368 0.936545629894391 0.9586559287413796 0.0442205976939769 1 1 1 1 K03325 0.2828571428571428 0.4558404558404558 ACR3, arsB; arsenite transporter 272.0 288.0 282.0 3.0 0.976271186440678 P 114.0 181.0 3.0 0.966101694915254 COG0798 Arsenite_efflux_pump_ArsB,_ACR3_family ACR3 295.0 0.3864406779661017 0.6135593220338983 0.921050634055709 0.983935529537038 0.9524930817963736 0.062884895481329 1 1 1 1 K03326 0.0 0.0284900284900284 TC.DCUC, dcuC, dcuD; C4-dicarboxylate transporter, DcuC family 396.0 17.0 15.0 2.0 0.894736842105263 C 0.0 19.0 1.0 1.0 COG3069 C4-dicarboxylate_transporter_DcuC DcuC 19.0 0.0 1.0 0.0120089358597202 0.0203345191063197 0.0161717274830199 0.0083255832465994 0 0 0 0 K03327 0.0057142857142857 0.433048433048433 TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family 188.0 242.0 240.0 2.0 0.991803278688525 V 2.0 243.0 1.0 1.0 COG0534 Na+-driven_multidrug_efflux_pump,_DinF/NorM/MATE_family NorM 245.0 0.0081632653061224 0.9918367346938776 0.834927903590662 0.886522763967045 0.8607253337788535 0.0515948603763829 0 0 1 1 K03328 0.0428571428571428 0.2706552706552707 TC.PST; polysaccharide transporter, PST family 119.0 148.0 142.0 4.0 0.919254658385093 S 20.0 140.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 160.0 0.125 0.875 0.0031161202995992 0.0262487647521968 0.014682442525898 0.0231326444525976 0 0 0 0 K03329 0.0 0.0142450142450142 yahN; amino acid exporter 183.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 5.0 0.0 1.0 0.0535796282946749 0.151879622546159 0.1027296254204169 0.0982999942514841 0 0 0 0 K03330 0.8914285714285715 0.0028490028490028 gatE; glutamyl-tRNA(Gln) amidotransferase subunit E [EC:6.3.5.7] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 465.0 309.0 297.0 2.0 0.962616822429906 J 320.0 1.0 1.0 1.0 COG2511 Archaeal_Glu-tRNAGln_amidotransferase_subunit_E,_contains_GAD_domain GatE 321.0 0.9968847352024922 0.0031152647975077 0.992206554295619 0.844984317544152 0.9185954359198856 0.1472222367514669 0 0 1 1 K03331 0.0028571428571428 0.0 DCXR; L-xylulose reductase [EC:1.1.1.10] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 236.0 1.0 0.0 1.0 1.0 Q 1.0 0.0 1.0 1.0 KOG1207 1.0 1.0 0.0 0 0 0 0 K03332 0.0028571428571428 0.0997150997150997 fruA; fructan beta-fructosidase [EC:3.2.1.80] path:map00051 Fructose and mannose metabolism 183.0 42.0 39.0 6.0 0.823529411764706 G 1.0 50.0 6.0 0.843137254901961 COG1621 Sucrose-6-phosphate_hydrolase_SacC,_GH32_family SacC 51.0 0.0196078431372549 0.9803921568627452 0.0255647412567919 0.0517309762647536 0.0386478587607727 0.0261662350079617 0 0 0 0 K03333 0.0057142857142857 0.0997150997150997 choD; cholesterol oxidase [EC:1.1.3.6] path:map00984,path:map01120 Steroid degradation,Microbial metabolism in diverse environments 325.0 55.0 54.0 5.0 0.932203389830508 E 2.0 57.0 3.0 0.949152542372881 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 59.0 0.0338983050847457 0.9661016949152542 0.0180576478873288 0.0273432058600981 0.0227004268737134 0.0092855579727692 0 0 0 0 K03335 0.0257142857142857 0.1623931623931624 iolE; inosose dehydratase [EC:4.2.1.44] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 94.0 102.0 101.0 2.0 0.990291262135922 G 12.0 91.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 103.0 0.116504854368932 0.883495145631068 0.0136668438587477 0.041006029393449 0.0273364366260983 0.0273391855347013 0 0 0 0 K03336 0.0 0.1168091168091168 iolD; 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing) [EC:3.7.1.22] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 534.0 43.0 42.0 3.0 0.955555555555556 E 0.0 45.0 2.0 0.977777777777778 COG3962 TPP-dependent_trihydroxycyclohexane-1,2-dione_(THcHDO)_dehydratase,_myo-inositol_metabolism IolD 45.0 0.0 1.0 0.0567712544070588 0.47521319139837 0.2659922229027144 0.4184419369913111 0 0 0 0 K03337 0.0114285714285714 0.1282051282051282 iolB; 5-deoxy-glucuronate isomerase [EC:5.3.1.30] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 167.0 54.0 0.0 1.0 1.0 G 4.0 50.0 1.0 1.0 COG3718 5-deoxy-D-glucuronate_isomerase IolB 54.0 0.074074074074074 0.925925925925926 0.820846844509066 0.965213002600625 0.8930299235548456 0.144366158091559 1 1 1 1 K03338 0.02 0.1139601139601139 iolC; 5-dehydro-2-deoxygluconokinase [EC:2.7.1.92] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 254.0 47.0 44.0 3.0 0.886792452830189 G 8.0 44.0 3.0 0.943396226415094 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 52.0 0.1538461538461538 0.8461538461538461 0.139428039441295 0.900410574024748 0.5199193067330214 0.760982534583453 0 0 0 0 K03339 0.0 0.0 iolJ; 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase [EC:4.1.2.29] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 16.0 0.0 1.0 1.0 G 0.0 0.0 1.0 1.0 COG0191 Fructose/tagatose_bisphosphate_aldolase Fba 0.0 0 0 0 0 K03340 0.0485714285714285 0.1196581196581196 dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16] path:map00300,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 148.0 27.0 15.0 4.0 0.509433962264151 E 17.0 42.0 6.0 0.254237288135593 COG0057 Glyceraldehyde-3-phosphate_dehydrogenase/erythrose-4-phosphate_dehydrogenase GapA 59.0 0.288135593220339 0.711864406779661 0.0578129832637069 0.909730073907952 0.4837715285858294 0.8519170906442451 0 0 0 0 K03341 0.0514285714285714 0.0 SEPSECS; O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2] path:map00450,path:map00970,path:map01100 Selenocompound metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways 400.0 20.0 0.0 1.0 1.0 J 20.0 0.0 1.0 1.0 KOG4482 20.0 1.0 0.0 0.0018279641405154 0.0124369812794584 0.0071324727099869 0.010609017138943 0 0 0 0 K03342 0.0028571428571428 0.2991452991452991 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 194.0 115.0 112.0 3.0 0.958333333333333 EH 1.0 115.0 2.0 0.6 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 116.0 0.0086206896551724 0.9913793103448276 0.0319372536734743 0.0675481077772636 0.0497426807253689 0.0356108541037892 0 0 0 0 K03343 0.0 0.0256410256410256 puo; putrescine oxidase [EC:1.4.3.10] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 334.0 9.0 0.0 1.0 1.0 E 0.0 9.0 1.0 1.0 COG1231 Monoamine_oxidase YobN 9.0 0.0 1.0 0.0468900180297855 0.143863618619734 0.0953768183247597 0.0969736005899485 0 0 0 0 K03346 0.0 0.0626780626780626 dnaB; replication initiation and membrane attachment protein 203.0 24.0 0.0 1.0 1.0 L 0.0 24.0 1.0 1.0 COG3611 Replication_initiation_and_membrane_attachment_protein_DnaB DnaB2 24.0 0.0 1.0 0.0060637910585095 0.010249287372846 0.0081565392156777 0.0041854963143365 0 0 0 0 K03350 0.0 0.0056980056980056 APC3, CDC27; anaphase-promoting complex subunit 3 path:map04110,path:map04111,path:map04113,path:map04114,path:map04120,path:map04914,path:map05166 Cell cycle,Cell cycle - yeast,Meiosis - yeast,Oocyte meiosis,Ubiquitin mediated proteolysis,Progesterone-mediated oocyte maturation,Human T-cell leukemia virus 1 infection 205.0 2.0 0.0 1.0 1.0 D 0.0 2.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 2.0 0.0 1.0 0 0 0 0 K03354 0.0171428571428571 0.0 APC7, ANAPC7; anaphase-promoting complex subunit 7 path:map04110,path:map04111,path:map04113,path:map04114,path:map04120,path:map04914,path:map05166 Cell cycle,Cell cycle - yeast,Meiosis - yeast,Oocyte meiosis,Ubiquitin mediated proteolysis,Progesterone-mediated oocyte maturation,Human T-cell leukemia virus 1 infection 162.0 8.0 7.0 2.0 0.888888888888889 S 9.0 0.0 1.0 1.0 KOG0084 9.0 1.0 0.0 0.239915784236726 0.755018178771594 0.49746698150416 0.5151023945348681 0 0 0 0 K03355 0.0028571428571428 0.0 APC8, CDC23; anaphase-promoting complex subunit 8 path:map04110,path:map04111,path:map04113,path:map04114,path:map04120,path:map04914,path:map05166 Cell cycle,Cell cycle - yeast,Meiosis - yeast,Oocyte meiosis,Ubiquitin mediated proteolysis,Progesterone-mediated oocyte maturation,Human T-cell leukemia virus 1 infection 386.0 1.0 0.0 1.0 1.0 DO 1.0 0.0 1.0 1.0 COG0013 Alanyl-tRNA_synthetase AlaS 1.0 1.0 0.0 0 0 0 0 K03365 0.0 0.0028490028490028 FCY1; cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21] path:map00240,path:map00330,path:map01100,path:map01232 Pyrimidine metabolism,Arginine and proline metabolism,Metabolic pathways,Nucleotide metabolism 425.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 1.0 0.0 1.0 0 0 0 0 K03366 0.0028571428571428 0.1168091168091168 butA, budC; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] path:map00650,path:map01110 Butanoate metabolism,Biosynthesis of secondary metabolites 204.0 50.0 49.0 2.0 0.980392156862745 IQ 1.0 50.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 51.0 0.0196078431372549 0.9803921568627452 0.0508233100854591 0.774344607391374 0.4125839587384166 0.7235212973059149 0 0 0 0 K03367 0.0 0.0284900284900284 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] path:map00470,path:map00552,path:map01100,path:map01503,path:map02020,path:map05150 D-Amino acid metabolism,Teichoic acid biosynthesis,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Staphylococcus aureus infection 471.0 9.0 8.0 2.0 0.9 Q 0.0 10.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 10.0 0.0 1.0 0.0039650881587153 0.0119762840846724 0.0079706861216938 0.0080111959259571 0 0 0 0 K03379 0.0028571428571428 0.0683760683760683 chnB; cyclohexanone monooxygenase [EC:1.14.13.22] path:map00930,path:map01120,path:map01220 Caprolactam degradation,Microbial metabolism in diverse environments,Degradation of aromatic compounds 307.0 41.0 34.0 4.0 0.759259259259259 P 1.0 53.0 3.0 0.87037037037037 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 54.0 0.0185185185185185 0.9814814814814816 0.0097716745629874 0.01968043617683 0.0147260553699087 0.0099087616138426 0 0 0 0 K03380 0.0 0.0341880341880341 E1.14.13.7; phenol 2-monooxygenase (NADPH) [EC:1.14.13.7] path:map00623,path:map00627,path:map01120 Toluene degradation,Aminobenzoate degradation,Microbial metabolism in diverse environments 614.0 9.0 6.0 2.0 0.75 CH 0.0 12.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 12.0 0.0 1.0 0.0629524835680563 0.110905023893543 0.0869287537307996 0.0479525403254866 0 0 0 0 K03381 0.0 0.0512820512820512 catA; catechol 1,2-dioxygenase [EC:1.13.11.1] path:map00361,path:map00362,path:map00364,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Fluorobenzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 246.0 28.0 0.0 1.0 1.0 Q 0.0 28.0 1.0 1.0 COG3485 Protocatechuate_3,4-dioxygenase_beta_subunit PcaH 28.0 0.0 1.0 0.0017190459782039 0.0652247345688746 0.0334718902735392 0.0635056885906707 0 0 0 0 K03382 0.0 0.0056980056980056 atzB; hydroxydechloroatrazine ethylaminohydrolase [EC:3.5.4.43] path:map00791,path:map01100,path:map01120 Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 441.0 2.0 0.0 1.0 1.0 F 0.0 2.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 2.0 0.0 1.0 0 0 0 0 K03383 0.0 0.0284900284900284 atzD; cyanuric acid amidohydrolase [EC:3.5.2.15] path:map00791,path:map01100,path:map01120 Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 358.0 6.0 3.0 4.0 0.5 S 0.0 12.0 1.0 1.0 2DBC4 12.0 0.0 1.0 0.0075449546391998 0.0451946033823747 0.0263697790107872 0.0376496487431749 0 0 0 0 K03385 0.0057142857142857 0.1339031339031339 nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 233.0 51.0 48.0 3.0 0.910714285714286 C 4.0 52.0 4.0 0.892857142857143 COG3303 Formate-dependent_nitrite_reductase,_periplasmic_cytochrome_c552_subunit NrfA 56.0 0.0714285714285714 0.9285714285714286 0.0496026378015719 0.269607551127433 0.1596050944645024 0.2200049133258611 0 0 0 0 K03386 0.4571428571428571 0.698005698005698 PRDX2_4, ahpC; peroxiredoxin 2/4 [EC:1.11.1.24] path:map04214 Apoptosis - fly 78.0 581.0 579.0 2.0 0.996569468267582 O 213.0 369.0 4.0 0.835334476843911 COG0450 Alkyl_hydroperoxide_reductase_subunit_AhpC_(peroxiredoxin) AhpC 582.0 0.3659793814432989 0.634020618556701 0.888964423575872 0.616398834968195 0.7526816292720335 0.272565588607677 1 1 1 1 K03387 0.1942857142857142 0.2193732193732193 ahpF; NADH-dependent peroxiredoxin subunit F [EC:1.8.1.-] 221.0 87.0 17.0 2.0 0.554140127388535 O 78.0 78.0 3.0 0.605095541401274 COG3634 Alkyl_hydroperoxide_reductase_subunit_AhpF AhpF 156.0 0.5 0.5 0.477616654856803 0.728658120663506 0.6031373877601545 0.251041465806703 0 0 0 0 K03388 0.3742857142857143 0.1766381766381766 hdrA2; heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 154.0 615.0 611.0 5.0 0.985576923076923 C 430.0 168.0 13.0 0.878205128205128 COG1148 Heterodisulfide_reductase,_subunit_A_(polyferredoxin) HdrA 598.0 0.7190635451505016 0.2809364548494983 0.895221492592018 0.98786295588396 0.941542224237989 0.092641463291942 1 1 1 1 K03389 0.3771428571428571 0.1339031339031339 hdrB2; heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 134.0 359.0 0.0 1.0 1.0 C 279.0 80.0 2.0 0.947075208913649 COG2048 Heterodisulfide_reductase,_subunit_B HdrB 359.0 0.7771587743732591 0.2228412256267409 0.924603178042551 0.97848366721486 0.9515434226287056 0.053880489172309 1 1 1 1 K03390 0.3457142857142857 0.1196581196581196 hdrC2; heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 47.0 299.0 297.0 3.0 0.990066225165563 C 231.0 71.0 6.0 0.52317880794702 COG2048 Heterodisulfide_reductase,_subunit_B HdrB 302.0 0.7649006622516556 0.2350993377483443 0.832292107220065 0.941178902409734 0.8867355048148995 0.108886795189669 1 1 1 1 K03391 0.0 0.0056980056980056 pcpB; pentachlorophenol monooxygenase [EC:1.14.13.50] path:map00361,path:map00364,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Fluorobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 465.0 2.0 0.0 1.0 1.0 CH 0.0 2.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 2.0 0.0 1.0 0 0 0 0 K03392 0.0485714285714285 0.0968660968660968 ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 164.0 47.0 31.0 3.0 0.712121212121212 S 20.0 46.0 2.0 0.818181818181818 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 66.0 0.303030303030303 0.696969696969697 0.0992048653003907 0.325623007226063 0.2124139362632268 0.2264181419256723 0 0 0 0 K03394 0.2914285714285714 0.2877492877492877 cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 99.0 213.0 0.0 1.0 1.0 H 102.0 111.0 3.0 0.981220657276995 COG2243 Precorrin-2_methylase CobF 213.0 0.4788732394366197 0.5211267605633803 0.0981081011939053 0.0907380810881268 0.094423091141016 0.0073700201057785 0 0 0 0 K03395 0.0 0.0028490028490028 aac3-I; aminoglycoside 3-N-acetyltransferase I [EC:2.3.1.60] 155.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 1.0 0.0 1.0 0 0 0 0 K03396 0.0 0.0199430199430199 gfa; S-(hydroxymethyl)glutathione synthase [EC:4.4.1.22] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 188.0 3.0 0.0 3.0 0.428571428571429 S 0.0 7.0 1.0 1.0 COG3791 Uncharacterized_conserved_protein 7.0 0.0 1.0 0.0213037317956462 0.0184848991907465 0.0198943154931963 0.0028188326048997 0 0 0 0 K03397 0.0 0.0028490028490028 E6.3.2.20; indoleacetate---lysine synthetase [EC:6.3.2.20] 299.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 1.0 0.0 1.0 0 0 0 0 K03399 0.2942857142857142 0.0683760683760683 cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 103.0 138.0 0.0 1.0 1.0 H 112.0 25.0 3.0 0.884057971014493 COG2241 Precorrin-6B_methylase_1 CobL 137.0 0.8175182481751825 0.1824817518248175 0.0231324464857512 0.0411151340973509 0.032123790291551 0.0179826876115997 0 0 0 0 K03400 0.0028571428571428 0.0085470085470085 luxC; long-chain-fatty-acyl-CoA reductase [EC:1.2.1.50] path:map02020,path:map02024 Two-component system,Quorum sensing 419.0 4.0 3.0 2.0 0.8 C 1.0 4.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 5.0 0.2 0.8 0.0994239563680555 0.20400657157711 0.1517152639725827 0.1045826152090545 0 0 0 0 K03402 0.0 0.3105413105413105 argR, ahrC; transcriptional regulator of arginine metabolism 96.0 115.0 0.0 1.0 1.0 K 0.0 115.0 1.0 1.0 COG1438 Arginine_repressor ArgR 115.0 0.0 1.0 0.130351498755099 0.0899134912220209 0.1101324949885599 0.040438007533078 0 0 0 0 K03403 0.0114285714285714 0.0769230769230769 chlH, bchH; magnesium chelatase subunit H [EC:6.6.1.1] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 1009.0 56.0 55.0 2.0 0.982456140350877 H 4.0 53.0 1.0 1.0 COG1429 Cobalamin_biosynthesis_protein_CobN,_Mg-chelatase CobN 57.0 0.0701754385964912 0.9298245614035088 0.0183991200678637 0.0462701848039076 0.0323346524358856 0.0278710647360439 0 0 0 0 K03404 0.2685714285714285 0.2307692307692307 chlD, bchD; magnesium chelatase subunit D [EC:6.6.1.1] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 216.0 242.0 239.0 5.0 0.975806451612903 H 143.0 98.0 4.0 0.834677419354839 COG1239 Mg-chelatase_subunit_ChlI ChlI 241.0 0.5933609958506224 0.4066390041493776 0.284871526248811 0.73536779536379 0.5101196608063006 0.450496269114979 0 0 0 0 K03405 0.2371428571428571 0.3076923076923077 chlI, bchI; magnesium chelatase subunit I [EC:6.6.1.1] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 188.0 269.0 268.0 3.0 0.992619926199262 H 129.0 140.0 2.0 0.940959409594096 COG1239 Mg-chelatase_subunit_ChlI ChlI 269.0 0.4795539033457249 0.5204460966542751 0.520426965025882 0.947352954469735 0.7338899597478086 0.4269259894438529 0 1 0 1 K03406 0.0 0.0 mcp; methyl-accepting chemotaxis protein path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 1462.0 958.0 16.0 0.634824142422927 NT 0.0 0.0 50.0 0.885032537960955 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 0.0 0 0 0 0 K03407 0.2514285714285714 0.4757834757834758 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 82.0 298.0 138.0 9.0 0.58203125 T 144.0 366.0 19.0 0.764132553606238 COG0643 Chemotaxis_protein_histidine_kinase_CheA CheA 510.0 0.2823529411764706 0.7176470588235294 0.0208733785058092 0.166801772610946 0.0938375755583776 0.1459283941051368 0 0 0 0 K03408 0.2457142857142857 0.4415954415954416 cheW; purine-binding chemotaxis protein CheW path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 18.0 420.0 270.0 5.0 0.726643598615917 NT 178.0 400.0 8.0 0.967128027681661 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 578.0 0.3079584775086505 0.6920415224913494 0.0395691681847204 0.0281404485901752 0.0338548083874477 0.0114287195945452 0 0 0 0 K03409 0.0 0.2022792022792023 cheX; chemotaxis protein CheX path:map02030 Bacterial chemotaxis 36.0 88.0 77.0 3.0 0.88 N 0.0 100.0 4.0 0.88 COG1406 Chemotaxis_protein_CheX,_a_CheY~P-specific_phosphatase CheX 100.0 0.0 1.0 0.0559953140732548 0.401699024802638 0.2288471694379464 0.3457037107293832 0 0 0 0 K03410 0.2342857142857143 0.1794871794871795 cheC; chemotaxis protein CheC path:map02030 Bacterial chemotaxis 60.0 125.0 10.0 3.0 0.504032258064516 N 178.0 70.0 4.0 0.931451612903226 COG1776 Phosphoaspartate_phosphatase_CheC,_specific_for_CheY-P CheC 248.0 0.717741935483871 0.282258064516129 0.586882124756833 0.890167910441734 0.7385250175992835 0.303285785684901 0 1 0 1 K03411 0.2371428571428571 0.2792022792022792 cheD; chemotaxis protein CheD [EC:3.5.1.44] path:map02030 Bacterial chemotaxis 96.0 160.0 92.0 2.0 0.701754385964912 NT 92.0 136.0 2.0 0.995614035087719 COG1871 Chemotaxis_receptor_(MCP)_glutamine_deamidase_CheD CheD 228.0 0.4035087719298245 0.5964912280701754 0.69444968391896 0.699572038130119 0.6970108610245396 0.005122354211159 0 1 0 1 K03412 0.2342857142857143 0.4558404558404558 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 158.0 338.0 251.0 5.0 0.773455377574371 NT 113.0 324.0 8.0 0.956521739130435 COG2201 Chemotaxis_response_regulator_CheB,_contains_REC_and_protein-glutamate_methylesterase_domains CheB 437.0 0.2585812356979405 0.7414187643020596 0.126005186634128 0.239441223135719 0.1827232048849235 0.113436036501591 0 0 0 0 K03413 0.3142857142857143 0.49002849002849 cheY; two-component system, chemotaxis family, chemotaxis protein CheY path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 5.0 620.0 546.0 5.0 0.789808917197452 T 235.0 525.0 17.0 0.284076433121019 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 760.0 0.3092105263157895 0.6907894736842105 0.0339431241168959 0.102635666889359 0.0682893955031274 0.0686925427724631 0 0 0 0 K03414 0.0 0.1253561253561253 cheZ; chemotaxis protein CheZ path:map02030 Bacterial chemotaxis 70.0 57.0 56.0 2.0 0.982758620689655 NT 0.0 58.0 3.0 0.862068965517241 COG3143 Phosphoaspartate_phosphatase_CheZ,_dephosphorylates_CheY~P CheZ 58.0 0.0 1.0 0.0062052257374029 0.0067923106595247 0.0064987681984637 0.0005870849221217 0 0 0 0 K03415 0.0 0.1566951566951566 cheV; two-component system, chemotaxis family, chemotaxis protein CheV path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 93.0 60.0 32.0 2.0 0.681818181818182 T 0.0 87.0 5.0 0.625 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 87.0 0.0 1.0 0.0145215917595381 0.264334869553326 0.139428230656432 0.2498132777937879 0 0 0 0 K03416 0.0 0.0284900284900284 E2.1.3.1-5S; methylmalonyl-CoA carboxyltransferase 5S subunit [EC:2.1.3.1] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 460.0 11.0 0.0 1.0 1.0 C 0.0 11.0 2.0 0.636363636363636 COG5016 Pyruvate/oxaloacetate_carboxyltransferase OadA1 11.0 0.0 1.0 0.0228177435836158 0.0193695046463071 0.0210936241149614 0.0034482389373086 0 0 0 0 K03417 0.1 0.1823361823361823 prpB; methylisocitrate lyase [EC:4.1.3.30] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 238.0 101.0 98.0 4.0 0.94392523364486 G 39.0 68.0 2.0 0.990654205607477 COG2513 2-Methylisocitrate_lyase_and_related_enzymes,_PEP_mutase_family PrpB 107.0 0.3644859813084112 0.6355140186915887 0.0059624386256793 0.155520564778486 0.0807415017020826 0.1495581261528067 0 0 0 0 K03418 0.0428571428571428 0.0227920227920227 dmfA2; N,N-dimethylformamidase large subunit [EC:3.5.1.56] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 68.0 18.0 15.0 5.0 0.75 C 15.0 10.0 9.0 0.346153846153846 COG1470 Uncharacterized_membrane_protein 25.0 0.6 0.4 0.171610003173325 0.201568239971586 0.1865891215724555 0.0299582367982609 0 0 0 0 K03420 0.6085714285714285 0.0085470085470085 psmR; proteasome regulatory subunit path:map03050 Proteasome 303.0 289.0 0.0 1.0 1.0 O 286.0 3.0 1.0 1.0 COG1222 ATP-dependent_26S_proteasome_regulatory_subunit RPT1 289.0 0.9896193771626296 0.0103806228373702 0.980775778583983 0.943328312032116 0.9620520453080494 0.037447466551867 0 0 1 1 K03421 0.1742857142857143 0.0 mcrC; methyl-coenzyme M reductase subunit C path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 183.0 64.0 0.0 1.0 1.0 H 64.0 0.0 1.0 1.0 COG4056 Methyl_coenzyme_M_reductase,_subunit_C McorC 64.0 1.0 0.0 0.0015141730969531 0.140890844394923 0.071202508745938 0.1393766712979699 0 0 0 0 K03422 0.1714285714285714 0.0 mcrD; methyl-coenzyme M reductase subunit D path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 109.0 75.0 0.0 1.0 1.0 H 75.0 0.0 1.0 1.0 COG4055 Methyl_coenzyme_M_reductase,_subunit_D McorD 75.0 1.0 0.0 0.646930246635055 0.8076965427151 0.7273133946750776 0.160766296080045 0 0 0 1 K03424 0.5742857142857143 0.9772079772079773 tatD; TatD DNase family protein [EC:3.1.21.-] 46.0 674.0 664.0 5.0 0.978229317851959 L 240.0 447.0 4.0 0.989840348330914 COG0084 3'->5'_ssDNA/RNA_exonuclease_TatD TatD 687.0 0.3493449781659388 0.6506550218340611 0.169496979930957 0.544474309953128 0.3569856449420425 0.3749773300221709 0 0 0 0 K03425 0.0 0.0284900284900284 tatE; sec-independent protein translocase protein TatE path:map03060,path:map03070 Protein export,Bacterial secretion system 58.0 11.0 0.0 1.0 1.0 U 0.0 11.0 1.0 1.0 COG1826 Twin-arginine_protein_secretion_pathway_components_TatA_and_TatB TatA 11.0 0.0 1.0 0.0985919428748598 0.131542305837566 0.1150671243562128 0.0329503629627061 0 0 0 0 K03426 0.0457142857142857 0.3105413105413105 E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22] path:map00760,path:map01100,path:map04146 Nicotinate and nicotinamide metabolism,Metabolic pathways,Peroxisome 132.0 129.0 0.0 1.0 1.0 L 17.0 111.0 1.0 1.0 COG2816 NADH_pyrophosphatase_NudC,_Nudix_superfamily NPY1 128.0 0.1328125 0.8671875 0.0170262618765234 0.112881588417158 0.0649539251468407 0.0958553265406346 0 0 0 0 K03427 0.0 0.0 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 591.0 439.0 9.0 0.76258064516129 V 0.0 0.0 13.0 0.922680412371134 COG0286 Type_I_restriction-modification_system,_DNA_methylase_subunit HsdM 0.0 0 0 0 0 K03428 0.0057142857142857 0.0854700854700854 bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 188.0 32.0 30.0 2.0 0.941176470588235 H 2.0 32.0 2.0 0.941176470588235 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 34.0 0.0588235294117647 0.9411764705882352 0.0173958794439886 0.0266507462692788 0.0220233128566336 0.0092548668252902 0 0 0 0 K03429 0.0028571428571428 0.1481481481481481 ugtP; processive 1,2-diacylglycerol beta-glucosyltransferase [EC:2.4.1.315] path:map00552,path:map00561,path:map01100 Teichoic acid biosynthesis,Glycerolipid metabolism,Metabolic pathways 149.0 65.0 0.0 1.0 1.0 M 1.0 64.0 2.0 0.984615384615385 COG0707 UDP-N-acetylglucosamine:LPS_N-acetylglucosamine_transferase MurG 65.0 0.0153846153846153 0.9846153846153848 0.0567223746040648 0.897828599071582 0.4772754868378234 0.8411062244675171 0 0 0 0 K03430 0.0514285714285714 0.0826210826210826 phnW; 2-aminoethylphosphonate-pyruvate transaminase [EC:2.6.1.37] path:map00440,path:map01100,path:map01120 Phosphonate and phosphinate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 129.0 32.0 18.0 4.0 0.64 E 18.0 32.0 5.0 0.62 COG0075 Archaeal_aspartate_aminotransferase_or_a_related_aminotransferase,_includes_purine_catabolism_protein_PucG PucG 50.0 0.36 0.64 0.080703038847934 0.226465480369011 0.1535842596084725 0.145762441521077 0 0 0 0 K03431 0.4885714285714285 0.7122507122507122 glmM; phosphoglucosamine mutase [EC:5.4.2.10] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 204.0 446.0 438.0 4.0 0.969565217391304 G 190.0 269.0 1.0 1.0 COG1109 Phosphomannomutase ManB 459.0 0.4139433551198257 0.5860566448801743 0.967691110224657 0.624649518161446 0.7961703141930515 0.343041592063211 1 1 1 1 K03432 0.9571428571428572 0.0968660968660968 psmA, prcA; proteasome alpha subunit [EC:3.4.25.1] path:map03050 Proteasome 171.0 444.0 0.0 1.0 1.0 O 407.0 37.0 1.0 1.0 COG0638 20S_proteasome,_alpha_and_beta_subunits PRE1 444.0 0.9166666666666666 0.0833333333333333 0.956586582560443 0.460950493518888 0.7087685380396656 0.495636089041555 1 1 1 1 K03433 0.9428571428571428 0.1054131054131054 psmB, prcB; proteasome beta subunit [EC:3.4.25.1] path:map03050 Proteasome 118.0 522.0 0.0 1.0 1.0 O 481.0 41.0 1.0 1.0 COG0638 20S_proteasome,_alpha_and_beta_subunits PRE1 522.0 0.921455938697318 0.0785440613026819 0.897237965609827 0.741405166945173 0.8193215662775 0.155832798664654 1 1 1 1 K03435 0.0 0.0541310541310541 fruR1, fruR; LacI family transcriptional regulator, fructose operon transcriptional repressor 292.0 22.0 0.0 1.0 1.0 K 0.0 22.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 22.0 0.0 1.0 0.011994493484473 0.231243400390738 0.1216189469376055 0.219248906906265 0 0 0 0 K03436 0.0514285714285714 0.1965811965811965 fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor 161.0 102.0 101.0 2.0 0.990291262135922 K 19.0 84.0 4.0 0.815533980582524 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 103.0 0.1844660194174757 0.8155339805825242 0.154920931987978 0.212039101408401 0.1834800166981894 0.057118169420423 0 0 0 0 K03437 0.02 0.6267806267806267 spoU; RNA methyltransferase, TrmH family 76.0 296.0 279.0 2.0 0.945686900958466 J 7.0 306.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 313.0 0.0223642172523961 0.977635782747604 0.467128426138134 0.272782364939137 0.3699553955386355 0.194346061198997 0 0 0 0 K03438 0.0028571428571428 0.9772079772079773 mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] 159.0 298.0 234.0 3.0 0.820936639118457 J 1.0 362.0 2.0 0.977961432506887 COG0275 16S_rRNA_C1402_N4-methylase_RsmH RmsH 363.0 0.0027548209366391 0.9972451790633609 0.0089366591214701 0.700892154244085 0.3549144066827776 0.6919554951226149 0 0 0 0 K03439 0.0285714285714285 0.6723646723646723 trmB, METTL1, TRM8; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] 58.0 231.0 218.0 4.0 0.888461538461538 J 10.0 250.0 3.0 0.907692307692308 COG0220 tRNA_G46_N7-methylase_TrmB TrmB 260.0 0.0384615384615384 0.9615384615384616 0.697392872364506 0.393137139719847 0.5452650060421764 0.304255732644659 0 1 0 1 K03440 0.0028571428571428 0.0 ASICN; acid-sensing ion channel, other 221.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1976 Translation_initiation_factor_6_(eIF-6) TIF6 1.0 1.0 0.0 0 0 0 0 K03442 0.2085714285714285 0.3333333333333333 mscS; small conductance mechanosensitive channel 101.0 256.0 0.0 1.0 1.0 M 93.0 163.0 2.0 0.79296875 COG0668 Small-conductance_mechanosensitive_channel MscS 256.0 0.36328125 0.63671875 0.714536991492787 0.836305517705032 0.7754212545989095 0.1217685262122449 0 1 0 1 K03444 0.0 0.017094017094017 ERD6, ESL1; MFS transporter, SP family, ERD6-like sugar transporter 130.0 7.0 6.0 2.0 0.875 EGP 0.0 8.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 8.0 0.0 1.0 0 0 0 0 K03445 0.02 0.0227920227920227 nepI; MFS transporter, DHA1 family, purine ribonucleoside efflux pump 341.0 17.0 16.0 2.0 0.944444444444444 EGP 8.0 10.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 18.0 0.4444444444444444 0.5555555555555556 0 0 0 0 K03446 0.0057142857142857 0.2962962962962963 emrB; MFS transporter, DHA2 family, multidrug resistance protein 336.0 106.0 37.0 3.0 0.517073170731707 EGP 2.0 203.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 205.0 0.0097560975609756 0.9902439024390244 0 0 0 0 K03449 0.0285714285714285 0.1481481481481481 MFS.CP; MFS transporter, CP family, cyanate transporter 302.0 68.0 57.0 2.0 0.860759493670886 P 11.0 68.0 2.0 0.860759493670886 COG2807 Cyanate_permease CynX 79.0 0.1392405063291139 0.8607594936708861 0.0459120691487094 0.116687925529319 0.0812999973390142 0.0707758563806096 0 0 0 0 K03451 0.0 0.0883190883190883 TC.BCT; betaine/carnitine transporter, BCCT family 440.0 36.0 24.0 3.0 0.679245283018868 M 0.0 53.0 1.0 1.0 COG1292 Choline-glycine_betaine_transporter BetT 53.0 0.0 1.0 0.0066731729796503 0.0127742603116655 0.0097237166456578 0.0061010873320152 0 0 0 0 K03453 0.1285714285714285 0.2592592592592592 TC.BASS; bile acid:Na+ symporter, BASS family 175.0 178.0 170.0 2.0 0.956989247311828 S 62.0 124.0 2.0 0.956989247311828 COG0385 Predicted_Na+-dependent_transporter_YfeH YfeH 186.0 0.3333333333333333 0.6666666666666666 0.509841873880781 0.927011425204724 0.7184266495427525 0.417169551323943 0 1 0 1 K03455 0.3885714285714285 0.4786324786324786 TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family 163.0 447.0 444.0 3.0 0.991130820399113 P 204.0 246.0 6.0 0.813747228381375 COG0475 Kef-type_K+_transport_system,_membrane_component_KefB KefB 450.0 0.4533333333333333 0.5466666666666666 0.608394973859386 0.980555217766764 0.7944750958130751 0.372160243907378 0 1 0 1 K03457 0.1085714285714285 0.1082621082621082 TC.NCS1; nucleobase:cation symporter-1, NCS1 family 281.0 70.0 31.0 4.0 0.593220338983051 F 52.0 66.0 2.0 0.567796610169492 COG1457 Purine-cytosine_permease_or_related_protein CodB 118.0 0.4406779661016949 0.559322033898305 0.0307883098799298 0.064741987487344 0.0477651486836369 0.0339536776074142 0 0 0 0 K03458 0.0771428571428571 0.2051282051282051 TC.NCS2; nucleobase:cation symporter-2, NCS2 family 313.0 126.0 0.0 1.0 1.0 F 34.0 92.0 2.0 0.992063492063492 COG2233 Xanthine/uracil_permease UraA 126.0 0.2698412698412698 0.7301587301587301 0.136917603788105 0.0615842495663363 0.0992509266772206 0.0753333542217687 0 0 0 0 K03459 0.0028571428571428 0.017094017094017 focB; formate transporter 59.0 9.0 0.0 1.0 1.0 P 1.0 7.0 1.0 1.0 COG2116 Formate/nitrite_transporter_FocA,_FNT_family FocA 8.0 0.125 0.875 0.444338754381332 0.145120291277657 0.2947295228294945 0.299218463103675 0 0 0 0 K03462 0.0085714285714285 0.0313390313390313 NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12] path:map00760,path:map01100,path:map04621 Nicotinate and nicotinamide metabolism,Metabolic pathways,NOD-like receptor signaling pathway 433.0 15.0 0.0 1.0 1.0 H 4.0 11.0 1.0 1.0 COG1488 Nicotinic_acid_phosphoribosyltransferase PncB 15.0 0.2666666666666666 0.7333333333333333 0.0563295970037818 0.227329139468289 0.1418293682360354 0.1709995424645072 0 0 0 0 K03464 0.0085714285714285 0.0541310541310541 catC; muconolactone D-isomerase [EC:5.3.3.4] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 92.0 24.0 0.0 1.0 1.0 Q 3.0 22.0 2.0 0.96 COG4829 Muconolactone_delta-isomerase CatC1 25.0 0.12 0.88 0.0096866871842082 0.0344818304754465 0.0220842588298273 0.0247951432912383 0 0 0 0 K03465 0.3171428571428571 0.3732193732193732 thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] path:map00240,path:map00670,path:map01100,path:map01232 Pyrimidine metabolism,One carbon pool by folate,Metabolic pathways,Nucleotide metabolism 72.0 201.0 153.0 4.0 0.791338582677165 F 115.0 139.0 2.0 0.980314960629921 COG1351 Thymidylate_synthase_ThyX,_FAD-dependent_family ThyX 254.0 0.452755905511811 0.547244094488189 0.984749268943887 0.921292120128717 0.953020694536302 0.06345714881517 1 1 1 1 K03466 0.08 0.925925925925926 ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family 91.0 463.0 439.0 16.0 0.851102941176471 D 29.0 509.0 26.0 0.851102941176471 COG1674 DNA_segregation_ATPase_FtsK/SpoIIIE_or_related_protein FtsK 538.0 0.053903345724907 0.9460966542750928 0.577073653038304 0.918790832471987 0.7479322427551456 0.3417171794336829 0 1 0 1 K03468 0.0 0.0056980056980056 aaeB; p-hydroxybenzoic acid efflux pump subunit AaeB 602.0 2.0 1.0 2.0 0.666666666666667 U 0.0 3.0 1.0 1.0 COG1289 Uncharacterized_membrane_protein_YccC YccC 3.0 0.0 1.0 0 0 0 0 K03469 0.3685714285714285 0.8034188034188035 rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] path:map03030 DNA replication 34.0 467.0 462.0 7.0 0.972916666666667 L 158.0 321.0 6.0 0.9625 COG0328 Ribonuclease_HI RnhA 479.0 0.3298538622129436 0.6701461377870563 0.0391906072539342 0.521211931025874 0.2802012691399041 0.4820213237719398 0 0 0 0 K03470 0.9342857142857144 0.9430199430199432 rnhB; ribonuclease HII [EC:3.1.26.4] path:map03030 DNA replication 47.0 669.0 653.0 3.0 0.957081545064378 L 348.0 351.0 3.0 0.969957081545064 COG0164 Ribonuclease_HII RnhB 699.0 0.4978540772532189 0.5021459227467812 0.0522928860177968 0.691996831128793 0.3721448585732949 0.6397039451109962 0 0 0 0 K03471 0.06 0.1225071225071225 rnhC; ribonuclease HIII [EC:3.1.26.4] path:map03030 DNA replication 118.0 66.0 0.0 1.0 1.0 L 21.0 44.0 2.0 0.818181818181818 COG1039 Ribonuclease_HIII RnhC 65.0 0.3230769230769231 0.676923076923077 0.84021714122632 0.0384765735288141 0.439346857377567 0.8017405676975059 1 1 1 1 K03472 0.0 0.037037037037037 epd; D-erythrose 4-phosphate dehydrogenase [EC:1.2.1.72] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 329.0 11.0 7.0 2.0 0.733333333333333 G 0.0 15.0 1.0 1.0 COG0057 Glyceraldehyde-3-phosphate_dehydrogenase/erythrose-4-phosphate_dehydrogenase GapA 15.0 0.0 1.0 0.0030634289905253 0.0057311772737101 0.0043973031321177 0.0026677482831848 0 0 0 0 K03473 0.0 0.0797720797720797 pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 309.0 23.0 20.0 3.0 0.821428571428571 H 0.0 28.0 2.0 0.928571428571429 COG0111 Phosphoglycerate_dehydrogenase_or_related_dehydrogenase SerA 28.0 0.0 1.0 0.0163303864378434 0.0394730663897458 0.0279017264137945 0.0231426799519024 0 0 0 0 K03474 0.0 0.5299145299145299 pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 133.0 176.0 158.0 4.0 0.858536585365854 H 0.0 205.0 3.0 0.834146341463415 COG0854 Pyridoxine_5'-phosphate_synthase_PdxJ PdxJ 205.0 0.0 1.0 0.0042628138084586 0.0018609618039235 0.003061887806191 0.0024018520045351 0 0 0 0 K03475 0.0 0.094017094017094 ulaA, sgaT; ascorbate PTS system EIIC component path:map00053,path:map01100,path:map01120,path:map02060 Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 379.0 34.0 22.0 2.0 0.739130434782609 S 0.0 46.0 1.0 1.0 COG3037 Ascorbate-specific_PTS_system_IIC_component_UlaA UlaA 46.0 0.0 1.0 0.197284261154606 0.124375717664078 0.160829989409342 0.072908543490528 0 0 0 0 K03476 0.12 0.0256410256410256 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-] path:map00053,path:map01100,path:map01120 Ascorbate and aldarate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 254.0 59.0 57.0 2.0 0.967213114754098 S 52.0 9.0 1.0 1.0 COG2220 L-ascorbate_lactonase_UlaG,_metallo-beta-lactamase_superfamily UlaG 61.0 0.8524590163934426 0.1475409836065573 0.0055462330037261 0.0175785202218778 0.0115623766128019 0.0120322872181517 0 0 0 0 K03477 0.0 0.0227920227920227 ulaR; DeoR family transcriptional regulator, ulaG and ulaABCDEF operon transcriptional repressor 254.0 9.0 0.0 1.0 1.0 K 0.0 9.0 2.0 0.888888888888889 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 9.0 0.0 1.0 0.0171198889124612 0.0378774741924656 0.0274986815524634 0.0207575852800044 0 0 0 0 K03478 0.0057142857142857 0.1566951566951566 chbG; chitin disaccharide deacetylase [EC:3.5.1.105] 126.0 63.0 0.0 1.0 1.0 G 2.0 61.0 1.0 1.0 COG3394 Chitooligosaccharide_deacetylase_ChbG,_YdjC/CelG_family ChbG 63.0 0.0317460317460317 0.9682539682539684 0.405978056925842 0.209060047342023 0.3075190521339325 0.196918009583819 0 0 0 0 K03480 0.0 0.0484330484330484 glcT; transcriptional antiterminator 235.0 21.0 0.0 1.0 1.0 K 0.0 21.0 2.0 0.952380952380952 COG3711 Transcriptional_antiterminator BglG 21.0 0.0 1.0 0.0490498581191014 0.381677200590342 0.2153635293547217 0.3326273424712406 0 0 0 0 K03481 0.0 0.0256410256410256 glvR; RpiR family transcriptional regulator, glv operon transcriptional regulator 213.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG1737 DNA-binding_transcriptional_regulator,_MurR/RpiR_family,_contains_HTH_and_SIS_domains RpiR 14.0 0.0 1.0 0.0014088199967098 0.0519445456173194 0.0266766828070145 0.0505357256206096 0 0 0 0 K03482 0.0 0.0085470085470085 yidP; GntR family transcriptional regulator, glv operon transcriptional regulator 229.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 5.0 0.0 1.0 1.82063730523716e-12 0.0183095601848759 0.0091547800933482 0.0183095601830552 0 0 0 0 K03483 0.0 0.1082621082621082 mtlR; mannitol operon transcriptional activator 156.0 25.0 12.0 4.0 0.454545454545455 J 0.0 55.0 3.0 0.454545454545455 COG0130 tRNA_U55_pseudouridine_synthase_TruB,_may_also_work_on_U342_of_tmRNA TruB 55.0 0.0 1.0 0.967290117948878 0.0389482014198325 0.5031191596843553 0.9283419165290456 0 0 1 1 K03484 0.0 0.1054131054131054 scrR; LacI family transcriptional regulator, sucrose operon repressor 176.0 48.0 0.0 1.0 1.0 K 0.0 48.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 48.0 0.0 1.0 0.0489974950727723 0.0246774490858306 0.0368374720793014 0.0243200459869416 0 0 0 0 K03485 0.0 0.0085470085470085 treR; LacI family transcriptional regulator, trehalose operon repressor 295.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 3.0 0.0 1.0 0 0 0 0 K03486 0.0 0.0512820512820512 treR2, treR; GntR family transcriptional regulator, trehalose operon transcriptional repressor 197.0 22.0 0.0 1.0 1.0 K 0.0 22.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 22.0 0.0 1.0 0.0043931688914664 0.0360144012182574 0.0202037850548619 0.0316212323267909 0 0 0 0 K03487 0.0 0.0227920227920227 ascG; LacI family transcriptional regulator, asc operon repressor 318.0 9.0 0.0 1.0 1.0 K 0.0 9.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 9.0 0.0 1.0 0.042740119725131 0.0373316387536711 0.040035879239401 0.0054084809714598 0 0 0 0 K03488 0.0 0.0712250712250712 licT, bglG; beta-glucoside operon transcriptional antiterminator 196.0 34.0 31.0 2.0 0.918918918918919 K 0.0 37.0 3.0 0.837837837837838 COG3711 Transcriptional_antiterminator BglG 37.0 0.0 1.0 0.0104581526367027 0.0120950128949806 0.0112765827658416 0.0016368602582779 0 0 0 0 K03489 0.0 0.0142450142450142 yydK; GntR family transcriptional regulator, transcriptional regulator of bglA 228.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 7.0 0.0 1.0 0.0084245306094095 0.0177956975780401 0.0131101140937248 0.0093711669686306 0 0 0 0 K03490 0.0 0.0284900284900284 chbR, celD; AraC family transcriptional regulator, dual regulator of chb operon 190.0 12.0 11.0 2.0 0.923076923076923 K 0.0 13.0 5.0 0.307692307692308 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 13.0 0.0 1.0 0.174129469161292 0.0313774019708 0.1027534355660459 0.142752067190492 0 0 0 0 K03491 0.0 0.0598290598290598 licR; probable licABCH operon transcriptional regulator 343.0 20.0 7.0 3.0 0.540540540540541 GKT 0.0 37.0 2.0 0.864864864864865 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 37.0 0.0 1.0 0 0 0 0 K03492 0.0 0.017094017094017 gmuR; GntR family transcriptional regulator, regulator of glucomannan utilization 230.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 8.0 0.0 1.0 2.9942268100284498e-12 0.0303559318403533 0.0151779659216737 0.030355931837359 0 0 0 0 K03493 0.0 0.0028490028490028 bglG1; transcriptional antiterminator 480.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG3711 Transcriptional_antiterminator BglG 1.0 0.0 1.0 0 0 0 0 K03495 0.0 0.7606837606837606 gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme 477.0 280.0 279.0 2.0 0.99644128113879 D 0.0 281.0 1.0 1.0 COG0445 tRNA_U34_5-carboxymethylaminomethyl_modifying_enzyme_MnmG/GidA MnmG 281.0 0.0 1.0 0.988823332675497 0.226060422158364 0.6074418774169306 0.7627629105171331 0 0 1 1 K03496 0.4 0.8660968660968661 parA, soj; chromosome partitioning protein 6.0 985.0 983.0 4.0 0.995955510616785 D 253.0 705.0 4.0 0.9211324570273 COG1192 ParA-like_ATPase_involved_in_chromosome/plasmid_partitioning_or_cellulose_biosynthesis_protein_BcsQ ParA 958.0 0.2640918580375783 0.7359081419624217 0.0803451002696496 0.300161456597652 0.1902532784336507 0.2198163563280024 0 0 0 0 K03497 0.1228571428571428 0.8803418803418803 parB, spo0J; ParB family transcriptional regulator, chromosome partitioning protein 5.0 647.0 615.0 9.0 0.907433380084151 K 67.0 569.0 16.0 0.896265560165975 COG1475 Chromosome_segregation_protein_Spo0J,_contains_ParB-like_nuclease_domain Spo0J 636.0 0.1053459119496855 0.8946540880503144 0.027224353874468 0.0926587981223115 0.0599415759983897 0.0654344442478434 0 0 0 0 K03498 0.5171428571428571 0.6666666666666666 trkH, trkG, ktrB, ktrD; trk/ktr system potassium uptake protein 161.0 638.0 628.0 3.0 0.981538461538462 P 297.0 353.0 2.0 0.981538461538462 COG0168 Trk-type_K+_transport_system,_membrane_component TrkG 650.0 0.4569230769230769 0.5430769230769231 0.776315530014625 0.754362813643868 0.7653391718292466 0.021952716370757 1 1 1 1 K03499 0.5142857142857142 0.7407407407407407 trkA, ktrA, ktrC; trk/ktr system potassium uptake protein 37.0 680.0 570.0 6.0 0.853199498117942 P 359.0 438.0 7.0 0.868255959849435 COG0569 Trk/Ktr_K+_transport_system_regulatory_component_TrkA/KtrA/KtrC,_RCK_domain TrkA 797.0 0.4504391468005019 0.5495608531994981 0.257332775402208 0.151457094530358 0.204394934966283 0.10587568087185 0 0 0 0 K03500 0.2228571428571428 0.698005698005698 rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176] 76.0 412.0 372.0 3.0 0.909492273730684 J 148.0 305.0 5.0 0.975717439293598 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 453.0 0.3267108167770419 0.673289183222958 0.463042899510198 0.337618663140892 0.400330781325545 0.125424236369306 0 0 0 0 K03501 0.0028571428571428 0.8461538461538461 gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] 62.0 271.0 235.0 2.0 0.882736156351792 J 1.0 306.0 2.0 0.986970684039088 COG0357 16S_rRNA_G527_N7-methylase_RsmG_(former_glucose-inhibited_division_protein_B) RsmG 307.0 0.003257328990228 0.996742671009772 0.188354667646613 0.106754380984505 0.147554524315559 0.0816002866621079 0 0 0 0 K03502 0.0 0.3076923076923077 umuC; DNA polymerase V 231.0 148.0 0.0 1.0 1.0 L 0.0 148.0 1.0 1.0 COG0389 Nucleotidyltransferase/DNA_polymerase_DinP_involved_in_DNA_repair DinP 148.0 0.0 1.0 0.0109028433714426 0.430746334821982 0.2208245890967123 0.4198434914505394 0 0 0 0 K03503 0.0 0.1994301994301994 umuD; DNA polymerase V [EC:3.4.21.-] 82.0 52.0 28.0 3.0 0.553191489361702 KT 0.0 94.0 1.0 1.0 COG1974 SOS-response_transcriptional_repressor_LexA_(RecA-mediated_autopeptidase) LexA 94.0 0.0 1.0 0.0024019182326552 0.0094541743655413 0.0059280462990982 0.007052256132886 0 0 0 0 K03516 0.0 0.0056980056980056 flhE; flagellar protein FlhE path:map02040 Flagellar assembly 130.0 3.0 0.0 1.0 1.0 N 0.0 3.0 2.0 0.666666666666667 294I9 3.0 0.0 1.0 0 0 0 0 K03517 0.5 0.6638176638176638 nadA; quinolinate synthase [EC:2.5.1.72] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 202.0 417.0 406.0 2.0 0.974299065420561 H 190.0 238.0 2.0 0.997663551401869 COG0379 Quinolinate_synthase NadA 428.0 0.4439252336448598 0.5560747663551402 0.0160213179836426 0.778502841711527 0.3972620798475847 0.7624815237278844 0 0 0 0 K03518 0.1742857142857143 0.3219373219373219 coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3] 93.0 345.0 337.0 2.0 0.977337110481586 C 105.0 247.0 4.0 0.963172804532578 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 352.0 0.2982954545454545 0.7017045454545454 0.782591388609374 0.0348621448892782 0.4087267667493261 0.7477292437200959 1 1 1 1 K03519 0.1542857142857142 0.2165242165242165 coxM, cutM; aerobic carbon-monoxide dehydrogenase medium subunit [EC:1.2.5.3] 142.0 274.0 0.0 1.0 1.0 C 107.0 167.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 274.0 0.3905109489051095 0.6094890510948905 0.731193248453164 0.975099386536587 0.8531463174948755 0.2439061380834229 0 1 0 1 K03520 0.1428571428571428 0.1709401709401709 coxL, cutL; aerobic carbon-monoxide dehydrogenase large subunit [EC:1.2.5.3] 459.0 282.0 280.0 2.0 0.992957746478873 C 118.0 166.0 2.0 0.992957746478873 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 284.0 0.4154929577464789 0.5845070422535211 0.0679268658879756 0.91074183632334 0.4893343511056578 0.8428149704353645 0 0 0 0 K03521 0.3971428571428571 0.6524216524216524 fixA, etfB; electron transfer flavoprotein beta subunit 83.0 575.0 0.0 1.0 1.0 C 226.0 349.0 2.0 0.99304347826087 COG2086 Electron_transfer_flavoprotein,_alpha_and_beta_subunits FixA 575.0 0.3930434782608695 0.6069565217391304 0.46647225886049 0.947191214895467 0.7068317368779785 0.480718956034977 0 0 0 0 K03522 0.4085714285714286 0.6552706552706553 fixB, etfA; electron transfer flavoprotein alpha subunit 131.0 620.0 0.0 1.0 1.0 C 239.0 381.0 7.0 0.958064516129032 COG2025 Electron_transfer_flavoprotein,_alpha_subunit_FixB FixB 620.0 0.3854838709677419 0.614516129032258 0.192479739783747 0.71993043754077 0.4562050886622585 0.527450697757023 0 0 0 0 K03523 0.2771428571428571 0.4786324786324786 bioY; biotin transport system substrate-specific component path:map02010 ABC transporters 89.0 276.0 265.0 2.0 0.961672473867596 S 97.0 190.0 2.0 0.961672473867596 COG1268 Biotin_transporter_BioY BioY 287.0 0.337979094076655 0.662020905923345 0.0113995934888087 0.235747738592641 0.1235736660407248 0.2243481451038323 0 0 0 0 K03524 0.4714285714285714 0.8660968660968661 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] path:map00780,path:map01100 Biotin metabolism,Metabolic pathways 17.0 391.0 307.0 5.0 0.69449378330373 H 199.0 323.0 8.0 0.863232682060391 COG0340 Biotin-(acetyl-CoA_carboxylase)_ligase BirA2 522.0 0.3812260536398467 0.6187739463601533 0.129303708245109 0.255099445847163 0.192201577046136 0.1257957376020539 0 0 0 0 K03525 0.0028571428571428 0.7578347578347578 coaX; type III pantothenate kinase [EC:2.7.1.33] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 96.0 167.0 84.0 5.0 0.581881533101045 F 1.0 286.0 4.0 0.958188153310104 COG1521 Pantothenate_kinase_type_III CoaX 287.0 0.0034843205574912 0.9965156794425089 0.348982725170132 0.671750533274867 0.5103666292224995 0.322767808104735 0 0 0 0 K03526 0.0057142857142857 0.7720797720797721 gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 295.0 260.0 247.0 3.0 0.948905109489051 I 2.0 272.0 1.0 1.0 COG0821 4-hydroxy-3-methylbut-2-en-1-yl_diphosphate_synthase_IspG/GcpE IspG 274.0 0.0072992700729927 0.9927007299270072 0.186921946681851 0.188995524081045 0.187958735381448 0.002073577399194 0 0 0 0 K03527 0.0085714285714285 0.8290598290598291 ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 77.0 244.0 167.0 7.0 0.648936170212766 IM 4.0 370.0 6.0 0.688829787234043 COG0761 4-Hydroxy-3-methylbut-2-enyl_diphosphate_reductase_IspH IspH 374.0 0.0106951871657754 0.9893048128342246 0.80304515163758 0.410732283379401 0.6068887175084905 0.3923128682581789 0 0 1 1 K03528 0.0 0.0541310541310541 zipA; cell division protein ZipA 165.0 19.0 0.0 1.0 1.0 D 0.0 19.0 1.0 1.0 COG3115 Cell_division_protein_ZipA,_interacts_with_FtsZ ZipA 19.0 0.0 1.0 0.0012146343862146 1.6069457667718799e-12 0.0006073171939107 0.0012146343846076 0 0 0 0 K03529 0.8228571428571428 0.7549857549857549 smc; chromosome segregation protein 208.0 557.0 508.0 5.0 0.913114754098361 D 332.0 281.0 7.0 0.890701468189233 COG1196 Chromosome_segregation_ATPase_Smc Smc 613.0 0.5415986949429038 0.4584013050570962 0.785083068481772 0.755687554901874 0.770385311691823 0.029395513579898 1 1 1 1 K03530 0.0457142857142857 0.886039886039886 hupB; DNA-binding protein HU-beta 57.0 511.0 510.0 3.0 0.996101364522417 L 17.0 495.0 1.0 1.0 COG0776 Bacterial_nucleoid_DNA-binding_protein_IHF-alpha HimA 512.0 0.033203125 0.966796875 0.0523191417858916 0.675699592134355 0.3640093669601233 0.6233804503484635 0 0 0 0 K03531 0.8457142857142858 0.9572649572649572 ftsZ; cell division protein FtsZ path:map04112 Cell cycle - Caulobacter 112.0 1017.0 1015.0 5.0 0.994134897360704 D 642.0 381.0 6.0 0.987292277614858 COG0206 Cell_division_GTPase_FtsZ FtsZ 1023.0 0.6275659824046921 0.3724340175953079 0.0590649603283809 0.334596366772994 0.1968306635506874 0.2755314064446131 0 0 0 0 K03532 0.0028571428571428 0.037037037037037 torC; trimethylamine-N-oxide reductase (cytochrome c), cytochrome c-type subunit TorC path:map00680,path:map01100,path:map01120,path:map02020 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 114.0 17.0 0.0 1.0 1.0 C 1.0 16.0 1.0 1.0 COG3005 Tetraheme_cytochrome_c_subunit_NapC_of_nitrate_or_TMAO_reductase NapC 17.0 0.0588235294117647 0.9411764705882352 0.042881556643436 0.0862721496921922 0.0645768531678141 0.0433905930487562 0 0 0 0 K03533 0.0142857142857142 0.0199430199430199 torD; TorA specific chaperone path:map00680,path:map01100,path:map01120,path:map02020 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 186.0 10.0 8.0 2.0 0.833333333333333 S 5.0 7.0 2.0 0.583333333333333 COG3381 Cytoplasmic_chaperone_TorD_involved_in_molybdoenzyme_TorA_maturation TorD 12.0 0.4166666666666667 0.5833333333333334 0.0254996330932753 0.0652373218671335 0.0453684774802044 0.0397376887738582 0 0 0 0 K03534 0.0314285714285714 0.1481481481481481 rhaM; L-rhamnose mutarotase [EC:5.1.3.32] 76.0 58.0 28.0 3.0 0.644444444444444 S 13.0 77.0 2.0 0.966666666666667 COG3254 L-rhamnose_mutarotase RhaM 90.0 0.1444444444444444 0.8555555555555555 0.0075395756252527 0.130067845906981 0.0688037107661168 0.1225282702817283 0 0 0 0 K03535 0.0028571428571428 0.0569800569800569 gudP; MFS transporter, ACS family, glucarate transporter 347.0 26.0 23.0 3.0 0.866666666666667 G 1.0 29.0 2.0 0.966666666666667 COG2271 Sugar_phosphate_permease UhpC 30.0 0.0333333333333333 0.9666666666666668 0.0155022901508529 0.0370278958137983 0.0262650929823256 0.0215256056629453 0 0 0 0 K03536 0.0 0.7891737891737892 rnpA; ribonuclease P protein component [EC:3.1.26.5] 14.0 276.0 275.0 2.0 0.996389891696751 J 0.0 277.0 2.0 0.996389891696751 COG0594 RNase_P_protein_component RnpA 277.0 0.0 1.0 0.394289572849141 0.37685195321374 0.3855707630314405 0.017437619635401 0 0 0 0 K03537 0.6142857142857143 0.0 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5] path:map03008 Ribosome biogenesis in eukaryotes 49.0 215.0 0.0 1.0 1.0 J 215.0 0.0 1.0 1.0 COG1369 RNase_P/RNase_MRP_subunit_POP5 POP5 215.0 1.0 0.0 0.692803219162559 0.815258941396723 0.754031080279641 0.1224557222341639 0 0 0 1 K03538 0.7742857142857142 0.0 POP4, RPP29; ribonuclease P protein subunit POP4 [EC:3.1.26.5] path:map03008 Ribosome biogenesis in eukaryotes 42.0 273.0 0.0 1.0 1.0 J 273.0 0.0 1.0 1.0 COG1588 RNase_P/RNase_MRP_subunit_p29 POP4 273.0 1.0 0.0 0.921663147486273 0.954298314239045 0.937980730862659 0.032635166752772 0 0 1 1 K03539 0.5485714285714286 0.0 RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5] path:map03008 Ribosome biogenesis in eukaryotes 75.0 192.0 0.0 1.0 1.0 J 192.0 0.0 1.0 1.0 COG1603 RNase_P/RNase_MRP_subunit_p30 RPP1 192.0 1.0 0.0 0.0490180743801553 0.868077342797889 0.4585477085890221 0.8190592684177337 0 0 0 0 K03540 0.7314285714285714 0.0028490028490028 RPR2, RPP21; ribonuclease P protein subunit RPR2 [EC:3.1.26.5] 38.0 254.0 252.0 3.0 0.988326848249027 J 256.0 1.0 2.0 0.996108949416342 COG2023 Ribonuclease_P_protein_subunit_RPR2 RPR2 257.0 0.9961089494163424 0.0038910505836575 0.912442720609381 0.916563416819708 0.9145030687145446 0.0041206962103269 0 0 1 1 K03543 0.0057142857142857 0.2763532763532763 emrA; membrane fusion protein, multidrug efflux system 188.0 157.0 156.0 2.0 0.993670886075949 V 2.0 156.0 2.0 0.987341772151899 COG1566 Multidrug_resistance_efflux_pump_EmrA EmrA 158.0 0.0126582278481012 0.9873417721518988 0.145458439956728 0.128544043131502 0.137001241544115 0.0169143968252259 0 0 0 0 K03544 0.0171428571428571 0.8319088319088319 clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX path:map04112 Cell cycle - Caulobacter 303.0 321.0 0.0 1.0 1.0 O 6.0 315.0 1.0 1.0 COG1219 ATP-dependent_protease_Clp,_ATPase_subunit_ClpX ClpX 321.0 0.0186915887850467 0.9813084112149532 0.921585595141163 0.448142834414333 0.684864214777748 0.47344276072683 1 1 1 1 K03545 0.0085714285714285 0.9772079772079773 tig; trigger factor 78.0 275.0 191.0 3.0 0.761772853185596 D 3.0 360.0 2.0 0.994490358126722 COG0544 FKBP-type_peptidyl-prolyl_cis-trans_isomerase_(trigger_factor) Tig 363.0 0.0082644628099173 0.9917355371900828 0.000463616889192 0.319976289971347 0.1602199534302695 0.319512673082155 0 0 0 0 K03546 0.7542857142857143 0.4928774928774929 sbcC, rad50; DNA repair protein SbcC/Rad50 20.0 503.0 481.0 8.0 0.898214285714286 L 341.0 214.0 11.0 0.892982456140351 COG0419 DNA_repair_exonuclease_SbcCD_ATPase_subunit SbcC 555.0 0.6144144144144145 0.3855855855855856 0.162542294427081 0.596770734280024 0.3796565143535525 0.434228439852943 0 0 0 0 K03547 0.7971428571428572 0.5470085470085471 sbcD, mre11; DNA repair protein SbcD/Mre11 30.0 557.0 556.0 2.0 0.99820788530466 L 329.0 233.0 4.0 0.98932384341637 COG0420 DNA_repair_exonuclease_SbcCD_nuclease_subunit SbcD 562.0 0.5854092526690391 0.4145907473309608 0.0122861348189747 0.444690295601294 0.2284882152101343 0.4324041607823192 0 0 0 0 K03548 0.0 0.1794871794871795 perM; putative permease 229.0 56.0 49.0 3.0 0.875 S 0.0 64.0 1.0 1.0 COG0628 Predicted_PurR-regulated_permease_PerM PerM 64.0 0.0 1.0 0.0058169061167671 0.418131615675413 0.21197426089609 0.4123147095586459 0 0 0 0 K03549 0.02 0.1595441595441595 kup; KUP system potassium uptake protein 485.0 77.0 0.0 1.0 1.0 P 9.0 68.0 1.0 1.0 COG3158 K+_uptake_protein_Kup Kup 77.0 0.1168831168831168 0.8831168831168831 0.371828475829435 0.195823017930782 0.2838257468801085 0.176005457898653 0 0 0 0 K03550 0.0228571428571428 0.9487179487179488 ruvA; holliday junction DNA helicase RuvA [EC:5.6.2.4] path:map03440 Homologous recombination 85.0 344.0 0.0 1.0 1.0 L 8.0 336.0 1.0 1.0 COG0632 Holliday_junction_resolvasome_RuvABC_DNA-binding_subunit RuvA 344.0 0.0232558139534883 0.9767441860465116 0.0367104513150458 0.372064492310299 0.2043874718126724 0.3353540409952532 0 0 0 0 K03551 0.0542857142857142 0.9544159544159544 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] path:map03440 Homologous recombination 254.0 361.0 360.0 2.0 0.997237569060773 L 20.0 342.0 4.0 0.966850828729282 COG2255 Holliday_junction_resolvasome_RuvABC,_ATP-dependent_DNA_helicase_subunit_RuvB RuvB 362.0 0.0552486187845303 0.9447513812154696 0.146288691294035 0.780650282458792 0.4634694868764135 0.634361591164757 0 0 0 0 K03552 0.5371428571428571 0.0 hjr; holliday junction resolvase Hjr [EC:3.1.21.10] 51.0 205.0 0.0 1.0 1.0 L 205.0 0.0 1.0 1.0 COG1591 Holliday_junction_resolvase_Hjc,_archaeal_type 205.0 1.0 0.0 0.933253080605453 0.842932049550862 0.8880925650781575 0.090321031054591 0 0 1 1 K03553 0.0142857142857142 0.9772079772079773 recA; recombination protein RecA path:map03440 Homologous recombination 269.0 366.0 0.0 1.0 1.0 L 6.0 360.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 366.0 0.0163934426229508 0.9836065573770492 0.579011385250074 0.842613023193988 0.7108122042220311 0.263601637943914 0 1 0 1 K03554 0.0 0.1054131054131054 rdgC; recombination associated protein RdgC 207.0 43.0 42.0 3.0 0.955555555555556 L 0.0 45.0 2.0 0.977777777777778 COG2974 DNA_recombination-dependent_growth_factor_RdgC RdgC 45.0 0.0 1.0 0.0018697910533143 0.012751394917342 0.0073105929853281 0.0108816038640277 0 0 0 0 K03555 0.3057142857142857 0.7749287749287749 mutS; DNA mismatch repair protein MutS path:map03430 Mismatch repair 498.0 447.0 445.0 3.0 0.993333333333333 L 147.0 303.0 2.0 0.993333333333333 COG0249 DNA_mismatch_repair_ATPase_MutS MutS 450.0 0.3266666666666666 0.6733333333333333 0.0169768420752007 0.550491263825223 0.2837340529502118 0.5335144217500223 0 0 0 0 K03556 0.0 0.1082621082621082 malT; LuxR family transcriptional regulator, maltose regulon positive regulatory protein 276.0 73.0 71.0 2.0 0.973333333333333 K 0.0 75.0 3.0 0.906666666666667 COG2909 ATP-,_maltotriose-_and_DNA-dependent_transcriptional_regulator_MalT MalT 75.0 0.0 1.0 0.0043812537209129 0.0790310211629095 0.0417061374419112 0.0746497674419966 0 0 0 0 K03557 0.0 0.0911680911680911 fis; Fis family transcriptional regulator, factor for inversion stimulation protein path:map05111 Biofilm formation - Vibrio cholerae 69.0 16.0 4.0 4.0 0.470588235294118 K 0.0 34.0 3.0 0.911764705882353 COG2901 DNA-binding_protein_Fis_(factor_for_inversion_stimulation) Fis 34.0 0.0 1.0 0.0014680221732782 0.00210284557841 0.001785433875844 0.0006348234051317 0 0 0 0 K03558 0.0 0.4273504273504273 cvpA; membrane protein required for colicin V production 80.0 156.0 0.0 1.0 1.0 S 0.0 156.0 2.0 0.987179487179487 COG1286 Colicin_V_production_accessory_protein_CvpA,_regulator_of_purF_expression_and_biofilm_formation CvpA 156.0 0.0 1.0 0.0023525370192013 0.212429255833817 0.1073908964265091 0.2100767188146157 0 0 0 0 K03559 0.0142857142857142 0.5555555555555556 exbD; biopolymer transport protein ExbD 24.0 466.0 461.0 2.0 0.989384288747346 U 5.0 466.0 2.0 0.989384288747346 COG0848 Biopolymer_transport_protein_ExbD ExbD 471.0 0.0106157112526539 0.989384288747346 0.0067684132652366 0.0219204467626116 0.0143444300139241 0.0151520334973749 0 0 0 0 K03560 0.0 0.3646723646723647 tolR; biopolymer transport protein TolR 72.0 162.0 158.0 2.0 0.975903614457831 U 0.0 166.0 1.0 1.0 COG0848 Biopolymer_transport_protein_ExbD ExbD 166.0 0.0 1.0 0.0248419927665248 0.0599966511309468 0.0424193219487358 0.035154658364422 0 0 0 0 K03561 0.0342857142857142 0.5612535612535613 exbB; biopolymer transport protein ExbB 34.0 443.0 440.0 10.0 0.973626373626374 U 13.0 455.0 10.0 0.94456289978678 COG0811 Biopolymer_transport_protein_ExbB/TolQ TolQ 468.0 0.0277777777777777 0.9722222222222222 0.0487055458506221 0.0760538917290659 0.062379718789844 0.0273483458784438 0 0 0 0 K03562 0.0 0.376068376068376 tolQ; biopolymer transport protein TolQ 138.0 151.0 148.0 3.0 0.967948717948718 U 0.0 156.0 1.0 1.0 COG0811 Biopolymer_transport_protein_ExbB/TolQ TolQ 156.0 0.0 1.0 0.0114358482719998 0.0223807339492148 0.0169082911106073 0.010944885677215 0 0 0 0 K03563 0.0 0.3276353276353276 csrA; carbon storage regulator path:map02020,path:map02025,path:map02026,path:map05111 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 42.0 96.0 42.0 2.0 0.64 T 0.0 150.0 1.0 1.0 COG1551 sRNA-binding_carbon_storage_regulator_CsrA CsrA 150.0 0.0 1.0 0.0364512444433191 0.213972162341577 0.125211703392448 0.1775209178982579 0 0 0 0 K03564 0.4914285714285714 0.7122507122507122 BCP, PRXQ, DOT5; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24] 10.0 814.0 813.0 4.0 0.996328029375765 O 386.0 390.0 5.0 0.984088127294982 COG1225 Peroxiredoxin Bcp 776.0 0.4974226804123711 0.5025773195876289 0.0194943681659429 0.0925699506536341 0.0560321594097885 0.0730755824876912 0 0 0 0 K03565 0.0 0.6524216524216524 recX; regulatory protein 13.0 233.0 0.0 1.0 1.0 S 0.0 232.0 1.0 1.0 COG2137 SOS_response_regulatory_protein_OraA/RecX,_interacts_with_RecA RecX 232.0 0.0 1.0 0.0289481829236266 0.765846449587654 0.3973973162556403 0.7368982666640275 0 0 0 0 K03566 0.0057142857142857 0.1424501424501424 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator path:map02026 Biofilm formation - Escherichia coli 155.0 121.0 108.0 2.0 0.902985074626866 K 2.0 132.0 2.0 0.888059701492537 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 134.0 0.0149253731343283 0.9850746268656716 0.0019553524171845 0.0084892624909569 0.0052223074540707 0.0065339100737723 0 0 0 0 K03567 0.0 0.1225071225071225 gcvR; glycine cleavage system transcriptional repressor path:map02026 Biofilm formation - Escherichia coli 90.0 43.0 42.0 3.0 0.955555555555556 E 0.0 45.0 2.0 0.977777777777778 COG2716 Glycine_cleavage_system_regulator_GcvR GcvR 45.0 0.0 1.0 0.0150403030493585 0.136340079362543 0.0756901912059507 0.1212997763131845 0 0 0 0 K03568 0.5457142857142857 0.4501424501424501 tldD; TldD protein 161.0 314.0 85.0 3.0 0.577205882352941 L 320.0 224.0 3.0 0.544117647058824 COG1530 Ribonuclease_G_or_E CafA 544.0 0.5882352941176471 0.4117647058823529 0.959527033396672 0.991916936330843 0.9757219848637576 0.0323899029341709 1 1 1 1 K03569 0.0628571428571428 0.8575498575498576 mreB; rod shape-determining protein MreB and related proteins 260.0 452.0 0.0 1.0 1.0 D 34.0 418.0 1.0 1.0 COG1077 Cell_shape-determining_ATPase_MreB,_actin-like_superfamily MreB 452.0 0.0752212389380531 0.9247787610619468 0.905386758049735 0.989608196846484 0.9474974774481096 0.084221438796749 1 1 1 1 K03570 0.0 0.7863247863247863 mreC; rod shape-determining protein MreC 52.0 272.0 266.0 3.0 0.971428571428571 M 0.0 280.0 2.0 0.992857142857143 COG1792 Cell_shape-determining_protein_MreC MreC 280.0 0.0 1.0 0.377675116082165 0.294525392384944 0.3361002542335545 0.0831497236972209 0 0 0 0 K03571 0.0 0.3931623931623931 mreD; rod shape-determining protein MreD 55.0 93.0 68.0 2.0 0.788135593220339 M 0.0 139.0 18.0 0.669064748201439 COG2891 Cell_shape-determining_protein_MreD MreD 139.0 0.0 1.0 0.0021953565468012 0.0311158348867523 0.0166555957167767 0.028920478339951 0 0 0 0 K03572 0.2828571428571428 0.7578347578347578 mutL; DNA mismatch repair protein MutL path:map03430 Mismatch repair 235.0 382.0 374.0 3.0 0.974489795918367 L 115.0 277.0 3.0 0.994897959183674 COG0323 DNA_mismatch_repair_ATPase_MutL MutL 392.0 0.2933673469387755 0.7066326530612245 0.347710214679372 0.698182949691314 0.522946582185343 0.350472735011942 0 0 0 0 K03573 0.0 0.0284900284900284 mutH; DNA mismatch repair protein MutH path:map03430 Mismatch repair 222.0 10.0 0.0 1.0 1.0 L 0.0 10.0 1.0 1.0 COG3066 DNA_mismatch_repair_protein_MutH MutH 10.0 0.0 1.0 0.009708865685637 0.0142720183650807 0.0119904420253588 0.0045631526794436 0 0 0 0 K03574 0.0 0.0 mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 573.0 116.0 18.0 0.509333333333333 F 0.0 0.0 22.0 0.600888888888889 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 0.0 0 0 0 0 K03575 0.2742857142857143 0.6723646723646723 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] path:map03410 Base excision repair 118.0 358.0 355.0 3.0 0.988950276243094 L 115.0 247.0 3.0 0.892265193370166 COG1194 Adenine-specific_DNA_glycosylase,_acts_on_AG_and_A-oxoG_pairs MutY 362.0 0.3176795580110497 0.6823204419889503 0.744212384298245 0.828301586921293 0.786256985609769 0.0840892026230479 0 1 0 1 K03576 0.0 0.1082621082621082 metR; LysR family transcriptional regulator, regulator for metE and metH 265.0 40.0 39.0 2.0 0.975609756097561 K 0.0 41.0 2.0 0.975609756097561 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 41.0 0.0 1.0 0.0062119135781479 0.0215347026946148 0.0138733081363813 0.0153227891164668 0 0 0 0 K03577 0.0514285714285714 0.0769230769230769 acrR, smeT; TetR/AcrR family transcriptional regulator, acrAB operon repressor 74.0 52.0 0.0 1.0 1.0 K 23.0 29.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 52.0 0.4423076923076923 0.5576923076923077 0.0245319884055693 0.0306109432197639 0.0275714658126666 0.0060789548141945 0 0 0 0 K03578 0.0171428571428571 0.2022792022792023 hrpA; ATP-dependent helicase HrpA [EC:3.6.4.13] 910.0 72.0 63.0 2.0 0.888888888888889 L 8.0 73.0 2.0 0.876543209876543 COG1643 HrpA-like_RNA_helicase HrpA 81.0 0.0987654320987654 0.9012345679012346 0.257229316606319 0.113564199541724 0.1853967580740215 0.1436651170645949 0 0 0 0 K03579 0.0 0.2706552706552707 hrpB; ATP-dependent helicase HrpB [EC:3.6.4.13] 533.0 106.0 0.0 1.0 1.0 L 0.0 106.0 1.0 1.0 COG1643 HrpA-like_RNA_helicase HrpA 106.0 0.0 1.0 0.0069845697738478 0.0203125269614176 0.0136485483676326 0.0133279571875698 0 0 0 0 K03580 0.0171428571428571 0.0854700854700854 hepA; ATP-dependent helicase HepA [EC:5.6.2.-] 507.0 18.0 4.0 3.0 0.5 L 6.0 30.0 1.0 1.0 COG0553 Superfamily_II_DNA_or_RNA_helicase,_SNF2_family HepA 36.0 0.1666666666666666 0.8333333333333334 0.016622230634696 0.0284593654170345 0.0225407980258652 0.0118371347823385 0 0 0 0 K03581 0.0428571428571428 0.4558404558404558 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] path:map03440 Homologous recombination 189.0 233.0 226.0 3.0 0.966804979253112 L 16.0 225.0 6.0 0.896265560165975 COG0507 ATPase/5-3_helicase_helicase_subunit_RecD_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecD 241.0 0.0663900414937759 0.933609958506224 0.278541543011197 0.713057649952601 0.495799596481899 0.434516106941404 0 0 0 0 K03582 0.0028571428571428 0.2222222222222222 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5] path:map03440 Homologous recombination 351.0 87.0 0.0 1.0 1.0 L 1.0 86.0 2.0 0.988505747126437 COG1074 3-5_helicase_subunit_RecB_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecB 87.0 0.0114942528735632 0.9885057471264368 0.0126914444308706 0.047570124357678 0.0301307843942742 0.0348786799268074 0 0 0 0 K03583 0.0 0.1709401709401709 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5] path:map03440 Homologous recombination 499.0 63.0 0.0 1.0 1.0 L 0.0 63.0 1.0 1.0 COG1330 Scaffold_subunit_RecC_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecC 63.0 0.0 1.0 0.020116860362381 0.0626764953619676 0.0413966778621743 0.0425596349995865 0 0 0 0 K03584 0.0 0.9145299145299144 recO; DNA repair protein RecO (recombination protein O) path:map03440 Homologous recombination 22.0 324.0 0.0 1.0 1.0 L 0.0 322.0 1.0 1.0 COG1381 Recombinational_DNA_repair_protein_RecO_(RecF_pathway) RecO 322.0 0.0 1.0 0.0241358948237749 0.0245959231033679 0.0243659089635714 0.0004600282795929 0 0 0 0 K03585 0.0 0.4102564102564102 acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system path:map01501,path:map01503 beta-Lactam resistance,Cationic antimicrobial peptide (CAMP) resistance 99.0 309.0 0.0 1.0 1.0 M 0.0 309.0 2.0 0.996763754045308 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 309.0 0.0 1.0 0.0093140869778529 0.0548841768776326 0.0320991319277427 0.0455700898997796 0 0 0 0 K03586 0.0 0.0854700854700854 ftsL; cell division protein FtsL 71.0 29.0 28.0 2.0 0.966666666666667 D 0.0 30.0 2.0 0.966666666666667 COG3116 Cell_division_protein_FtsL,_interacts_with_FtsB_and_FtsQ FtsL 30.0 0.0 1.0 0.007318403071468 0.0118790702165619 0.0095987366440149 0.0045606671450939 0 0 0 0 K03587 0.0028571428571428 0.8632478632478633 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 164.0 318.0 313.0 4.0 0.972477064220183 M 1.0 326.0 3.0 0.981651376146789 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 327.0 0.0030581039755351 0.9969418960244648 0.591412300891889 0.956540323218672 0.7739763120552805 0.365128022326783 0 0 0 1 K03588 0.0 0.9487179487179488 ftsW, spoVE; cell division protein FtsW path:map04112 Cell cycle - Caulobacter 128.0 380.0 365.0 4.0 0.952380952380952 D 0.0 399.0 2.0 0.994987468671679 COG0772 Peptodoglycan_polymerase_FtsW/RodA/SpoVE FtsW 399.0 0.0 1.0 0.263300550464247 0.961946150254495 0.612623350359371 0.6986455997902481 0 0 0 0 K03589 0.0 0.0 ftsQ; cell division protein FtsQ path:map04112 Cell cycle - Caulobacter 199.0 135.0 3.0 0.74812030075188 D 0.0 0.0 2.0 0.988721804511278 COG1589 Cell_division_septal_protein_FtsQ FtsQ 0.0 0 0 0 0 K03590 0.0 0.7464387464387464 ftsA; cell division protein FtsA path:map04112 Cell cycle - Caulobacter 160.0 274.0 0.0 1.0 1.0 D 0.0 274.0 1.0 1.0 COG0849 Cell_division_ATPase_FtsA FtsA 274.0 0.0 1.0 0.833456353451879 0.254648540122008 0.5440524467869434 0.578807813329871 0 0 1 1 K03591 0.0 0.0569800569800569 ftsN; cell division protein FtsN 85.0 21.0 0.0 1.0 1.0 D 0.0 21.0 1.0 1.0 COG3087 Cell_division_protein_FtsN FtsN 21.0 0.0 1.0 0.0370960478935706 0.0393649043984727 0.0382304761460216 0.002268856504902 0 0 0 0 K03592 0.5428571428571428 0.3931623931623931 pmbA; PmbA protein 49.0 452.0 428.0 2.0 0.949579831932773 S 303.0 173.0 2.0 0.991596638655462 COG0312 Zn-dependent_protease_PmbA/TldA_or_its_inactivated_homolog TldD 476.0 0.6365546218487395 0.3634453781512605 0.536616157053543 0.821674467223631 0.6791453121385871 0.285058310170088 0 1 0 1 K03593 0.6028571428571429 0.7037037037037037 mrp, NUBPL; ATP-binding protein involved in chromosome partitioning 138.0 578.0 561.0 7.0 0.949096880131363 D 310.0 299.0 6.0 0.922824302134647 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 609.0 0.5090311986863711 0.4909688013136289 0.001643279119468 0.167804654199162 0.0847239666593149 0.166161375079694 0 0 0 0 K03594 0.28 0.4245014245014245 bfr; bacterioferritin [EC:1.16.3.1] path:map00860 Porphyrin metabolism 11.0 172.0 36.0 5.0 0.52760736196319 P 119.0 204.0 8.0 0.570121951219512 COG2193 Bacterioferritin_(cytochrome_b1) Bfr 323.0 0.3684210526315789 0.631578947368421 0.784494742084945 0.649263624206563 0.7168791831457539 0.1352311178783819 1 1 1 1 K03595 0.0 0.8091168091168092 era, ERAL1; GTPase 183.0 270.0 252.0 4.0 0.882352941176471 S 0.0 306.0 4.0 0.911764705882353 COG1159 GTPase_Era,_involved_in_16S_rRNA_processing Era 306.0 0.0 1.0 0.719615005521824 0.288674962395726 0.504144983958775 0.430940043126098 0 0 0 1 K03596 0.0 0.9829059829059827 lepA; GTP-binding protein LepA path:map05134 Legionellosis 527.0 261.0 166.0 2.0 0.73314606741573 M 0.0 356.0 1.0 1.0 COG0481 Translation_elongation_factor_EF-4,_membrane-bound_GTPase LepA 356.0 0.0 1.0 0.0014734408454924 0.328783700061599 0.1651285704535457 0.3273102592161066 0 0 0 0 K03597 0.0 0.0626780626780626 rseA; sigma-E factor negative regulatory protein RseA 122.0 22.0 0.0 1.0 1.0 T 0.0 22.0 1.0 1.0 COG3073 RseA,_negative_regulator_of_sigma_E_activity RseA 22.0 0.0 1.0 0.0002418513161478 0.0014374190242144 0.000839635170181 0.0011955677080666 0 0 0 0 K03598 0.0 0.0712250712250712 rseB; sigma-E factor negative regulatory protein RseB 159.0 26.0 0.0 1.0 1.0 T 0.0 26.0 1.0 1.0 COG3026 RseB,_negative_regulator_of_sigma_E_activity RseB 26.0 0.0 1.0 0.002306746492185 0.0066839164215885 0.0044953314568867 0.0043771699294035 0 0 0 0 K03599 0.0 0.0769230769230769 sspA, mglA; stringent starvation protein A 196.0 27.0 26.0 2.0 0.964285714285714 O 0.0 28.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 28.0 0.0 1.0 0.0016797454772286 0.002741217012065 0.0022104812446468 0.0010614715348363 0 0 0 0 K03600 0.0 0.094017094017094 sspB; stringent starvation protein B 109.0 33.0 0.0 1.0 1.0 S 0.0 33.0 1.0 1.0 COG2969 Stringent_starvation_protein_B,_binds_SsrA_peptide SspB 33.0 0.0 1.0 0.0021936794944243 0.0043153002305058 0.003254489862465 0.0021216207360815 0 0 0 0 K03601 0.1228571428571428 0.8091168091168092 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] path:map03430 Mismatch repair 119.0 340.0 334.0 5.0 0.96045197740113 L 45.0 309.0 2.0 0.966101694915254 COG1570 Exonuclease_VII,_large_subunit XseA 354.0 0.1271186440677966 0.8728813559322034 0.0054388432696629 0.0153115960022506 0.0103752196359567 0.0098727527325876 0 0 0 0 K03602 0.1 0.7122507122507122 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] path:map03430 Mismatch repair 44.0 285.0 280.0 2.0 0.982758620689655 L 37.0 253.0 4.0 0.96551724137931 COG1722 Exonuclease_VII_small_subunit XseB 290.0 0.1275862068965517 0.8724137931034482 0.0088377643375644 0.11172544700576 0.0602816056716622 0.1028876826681955 0 0 0 0 K03603 0.0 0.0455840455840455 fadR; GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA 209.0 17.0 0.0 1.0 1.0 K 0.0 17.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 17.0 0.0 1.0 0.0037575470624162 0.0072467582916366 0.0055021526770264 0.0034892112292204 0 0 0 0 K03604 0.0 0.0712250712250712 purR; LacI family transcriptional regulator, purine nucleotide synthesis repressor 177.0 41.0 40.0 2.0 0.976190476190476 K 0.0 42.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 42.0 0.0 1.0 0.104307224637216 0.0112126493362659 0.0577599369867409 0.0930945753009501 0 0 0 0 K03605 0.22 0.2307692307692307 hyaD, hybD; hydrogenase maturation protease [EC:3.4.23.-] 57.0 172.0 145.0 4.0 0.839024390243902 C 101.0 112.0 3.0 0.938967136150235 COG0680 Ni,Fe-hydrogenase_maturation_factor HyaD 213.0 0.4741784037558685 0.5258215962441315 0.735026480333503 0.957419599283509 0.846223039808506 0.2223931189500059 0 1 0 1 K03606 0.0057142857142857 0.2336182336182336 wcaJ; undecaprenyl-phosphate glucose phosphotransferase [EC:2.7.8.31] path:map00543,path:map05111 Exopolysaccharide biosynthesis,Biofilm formation - Vibrio cholerae 166.0 94.0 83.0 2.0 0.895238095238095 M 2.0 103.0 3.0 0.619047619047619 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 105.0 0.019047619047619 0.9809523809523808 0.0175263884671459 0.0969810511155071 0.0572537197913265 0.0794546626483612 0 0 0 0 K03607 0.0 0.0398860398860398 proQ; ProP effector 130.0 15.0 14.0 2.0 0.9375 T 0.0 16.0 1.0 1.0 COG3109 sRNA-binding_protein_ProQ ProQ 16.0 0.0 1.0 0.0025430133145448 0.0039151290824865 0.0032290711985156 0.0013721157679417 0 0 0 0 K03608 0.0 0.282051282051282 minE; cell division topological specificity factor 59.0 100.0 0.0 1.0 1.0 D 0.0 100.0 1.0 1.0 COG0851 Septum_formation_topological_specificity_factor_MinE MinE 100.0 0.0 1.0 0.334475465544535 0.493264434323361 0.413869949933948 0.1587889687788259 0 0 0 0 K03609 0.5514285714285714 0.3931623931623931 minD; septum site-determining protein MinD 60.0 539.0 530.0 4.0 0.964221824686941 D 413.0 147.0 8.0 0.682142857142857 COG0455 MinD-like_ATPase_FlhG/YlxH,_activator_of_the_FlhF-type_GTPase FlhG 560.0 0.7375 0.2625 0.309615023532868 0.159281264426748 0.234448143979808 0.15033375910612 0 0 0 0 K03610 0.0 0.3447293447293447 minC; septum site-determining protein MinC 78.0 114.0 104.0 2.0 0.919354838709677 D 0.0 124.0 2.0 0.919354838709677 COG0850 Septum_site-determining_protein_MinC MinC 124.0 0.0 1.0 0.116824151720459 0.676210561993709 0.396517356857084 0.55938641027325 0 0 0 0 K03611 0.0914285714285714 0.2051282051282051 dsbB; protein dithiol:quinone oxidoreductase [EC:1.8.5.9] 88.0 80.0 45.0 2.0 0.695652173913043 O 34.0 81.0 2.0 0.947826086956522 COG1495 Disulfide_bond_formation_protein_DsbB DsbB 115.0 0.2956521739130435 0.7043478260869566 0.0029247655158187 0.208367532071782 0.1056461487938003 0.2054427665559633 0 0 0 0 K03612 0.0342857142857142 0.2649572649572649 rnfG; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit G 83.0 106.0 101.0 3.0 0.929824561403509 C 12.0 102.0 1.0 1.0 COG4659 Na+-translocating_ferredoxin:NAD+_oxidoreductase_RNF,_RnfG_subunit RnfG 114.0 0.1052631578947368 0.8947368421052632 0.0156283882662473 0.210959453829199 0.1132939210477231 0.1953310655629517 0 0 0 0 K03613 0.0342857142857142 0.2592592592592592 rnfE; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit E 164.0 102.0 84.0 2.0 0.85 C 12.0 108.0 2.0 0.916666666666667 COG4660 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfE_subunit RnfE 120.0 0.1 0.9 0.387620207199101 0.404067929823464 0.3958440685112825 0.016447722624363 0 0 0 0 K03614 0.04 0.2905982905982906 rnfD; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit D [EC:7.1.1.11 7.2.1.2] 224.0 115.0 95.0 2.0 0.851851851851852 C 14.0 121.0 1.0 1.0 COG4658 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfD_subunit RnfD 135.0 0.1037037037037037 0.8962962962962963 0.20052860870055 0.56005563136756 0.380292120034055 0.35952702266701 0 0 0 0 K03615 0.0485714285714285 0.3447293447293447 rnfC; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit C [EC:7.1.1.11 7.2.1.2] 201.0 139.0 134.0 6.0 0.908496732026144 C 17.0 136.0 9.0 0.810457516339869 COG4656 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfC_subunit RnfC 153.0 0.1111111111111111 0.8888888888888888 0.393005965710082 0.546601033150432 0.469803499430257 0.1535950674403499 0 0 0 0 K03616 0.0542857142857142 0.3361823361823361 rnfB; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit B [EC:7.1.1.11 7.2.1.2] 37.0 151.0 149.0 2.0 0.986928104575163 C 20.0 135.0 21.0 0.316129032258065 COG2878 Na+-translocating_ferredoxin:NAD+_oxidoreductase_RNF,_RnfB_subunit RnfB 155.0 0.1290322580645161 0.8709677419354839 0.295014291767123 0.139257271470684 0.2171357816189035 0.155757020296439 0 0 0 0 K03617 0.0342857142857142 0.2934472934472934 rnfA; H+/Na+-translocating ferredoxin:NAD+ oxidoreductase subunit A 160.0 97.0 85.0 5.0 0.740458015267176 C 12.0 120.0 4.0 0.825757575757576 COG4657 Na+-translocating_ferredoxin:NAD+_oxidoreductase_RNF,_RnfA_subunit RnfA 132.0 0.0909090909090909 0.9090909090909092 0.964730518570522 0.822907128014807 0.8938188232926645 0.141823390555715 1 1 1 1 K03618 0.0 0.0683760683760683 hyaF; hydrogenase-1 operon protein HyaF 80.0 21.0 16.0 2.0 0.807692307692308 C 0.0 26.0 4.0 0.769230769230769 COG1773 Flavorubredoxin NorV 26.0 0.0 1.0 0.0574021388728081 0.0967041178475322 0.0770531283601701 0.0393019789747241 0 0 0 0 K03619 0.0085714285714285 0.0569800569800569 hyaE; hydrogenase-1 operon protein HyaE 48.0 9.0 2.0 4.0 0.36 M 3.0 22.0 5.0 0.48 COG1999 Cytochrome_oxidase_Cu_insertion_factor,_SCO1/SenC/PrrC_family Sco1 25.0 0.12 0.88 0.0301882778470778 0.027783574924007 0.0289859263855424 0.0024047029230707 0 0 0 0 K03620 0.0485714285714285 0.1452991452991453 hyaC; Ni/Fe-hydrogenase 1 B-type cytochrome subunit path:map02020 Two-component system 38.0 79.0 0.0 1.0 1.0 C 20.0 59.0 3.0 0.518987341772152 COG1969 Ni,Fe-hydrogenase_I_cytochrome_b_subunit HyaC 79.0 0.2531645569620253 0.7468354430379747 0.0264231747557528 0.295006442309854 0.1607148085328034 0.2685832675541012 0 0 0 0 K03621 0.0 0.7065527065527065 plsX; phosphate acyltransferase [EC:2.3.1.274] path:map00561,path:map01100,path:map01110 Glycerolipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 220.0 255.0 0.0 1.0 1.0 I 0.0 255.0 1.0 1.0 COG0416 Acyl-ACP:phosphate_acyltransferase_(fatty_acid/phospholipid_biosynthesis) PlsX 255.0 0.0 1.0 0.402842320873604 0.224251084258052 0.313546702565828 0.1785912366155519 0 0 0 0 K03622 0.6971428571428572 0.0 ssh10b; archaea-specific DNA-binding protein 62.0 301.0 274.0 2.0 0.917682926829268 K 328.0 0.0 1.0 1.0 COG1581 DNA/RNA-binding_protein_AlbA/Ssh10b AlbA 328.0 1.0 0.0 0.0609169613665248 0.0446617630835611 0.0527893622250429 0.0162551982829637 0 0 0 0 K03623 0.0 0.0313390313390313 yhcO; ribonuclease inhibitor 83.0 11.0 0.0 1.0 1.0 K 0.0 11.0 1.0 1.0 COG2732 Barstar,_RNAse_(barnase)_inhibitor BarS 11.0 0.0 1.0 0.0220142742081424 0.0424991571353637 0.032256715671753 0.0204848829272213 0 0 0 0 K03624 0.0028571428571428 0.8376068376068376 greA; transcription elongation factor GreA 86.0 338.0 337.0 2.0 0.997050147492625 K 1.0 339.0 2.0 0.997058823529412 COG0782 Transcription_elongation_factor,_GreA/GreB_family GreA 340.0 0.0029411764705882 0.9970588235294118 0.0087900653542621 0.70274652806423 0.355768296709246 0.6939564627099679 0 0 0 0 K03625 0.0 0.9829059829059827 nusB; transcription antitermination protein NusB 51.0 322.0 297.0 2.0 0.927953890489914 K 0.0 347.0 2.0 0.985590778097983 COG0781 Transcription_antitermination_protein_NusB NusB 347.0 0.0 1.0 0.0126696121570275 0.706563280838232 0.3596164464976298 0.6938936686812045 0 0 0 0 K03626 0.8571428571428571 0.0 EGD2, NACA; nascent polypeptide-associated complex subunit alpha path:map04928 Parathyroid hormone synthesis, secretion and action 62.0 161.0 19.0 2.0 0.531353135313531 K 303.0 0.0 1.0 1.0 COG1308 Transcription_factor_homologous_to_NACalpha-BTF3 EGD2 303.0 1.0 0.0 0.446789418893046 0.0860250291566851 0.2664072240248655 0.3607643897363609 0 0 0 0 K03627 0.8 0.0 MBF1; putative transcription factor 75.0 285.0 0.0 1.0 1.0 K 285.0 0.0 1.0 1.0 COG1813 Archaeal_ribosome-binding_protein_aMBF1,_putative_translation_factor,_contains_Zn-ribbon_and_HTH_domains aMBF1 285.0 1.0 0.0 0.439511619763568 0.565078434021253 0.5022950268924105 0.125566814257685 0 0 0 0 K03628 0.0028571428571428 0.811965811965812 rho; transcription termination factor Rho path:map03018 RNA degradation 319.0 302.0 298.0 3.0 0.980519480519481 K 1.0 307.0 3.0 0.983766233766234 COG1158 Transcription_termination_factor_Rho Rho 308.0 0.0032467532467532 0.9967532467532468 0.160711280669182 0.129067605318584 0.144889442993883 0.031643675350598 0 0 0 0 K03629 0.0 0.7236467236467237 recF; DNA replication and repair protein RecF path:map03440 Homologous recombination 113.0 259.0 0.0 1.0 1.0 L 0.0 259.0 1.0 1.0 COG1195 Recombinational_DNA_repair_ATPase_RecF RecF 259.0 0.0 1.0 0.04058296354349 0.536895032599509 0.2887389980714995 0.496312069056019 0 0 0 0 K03630 0.1257142857142857 0.6951566951566952 radC; DNA repair protein RadC 91.0 241.0 79.0 2.0 0.598014888337469 L 60.0 343.0 1.0 1.0 COG2003 DNA_repair_protein_RadC,_contains_a_helix-hairpin-helix_DNA-binding_motif RadC 403.0 0.1488833746898263 0.8511166253101737 0.321828908700556 0.582695279404648 0.452262094052602 0.260866370704092 0 0 0 0 K03631 0.0028571428571428 0.8461538461538461 recN; DNA repair protein RecN (Recombination protein N) 244.0 310.0 0.0 1.0 1.0 L 1.0 309.0 1.0 1.0 COG0497 DNA_repair_ATPase_RecN RecN 310.0 0.0032258064516129 0.9967741935483873 0.658250417129066 0.501598684844283 0.5799245509866745 0.1566517322847829 0 0 0 1 K03632 0.0 0.0227920227920227 mukB; chromosome partition protein MukB 1052.0 8.0 0.0 1.0 1.0 D 0.0 8.0 2.0 0.625 COG3096 Chromosome_condensin_MukBEF,_ATPase_and_DNA-binding_subunit_MukB MukB 8.0 0.0 1.0 6.40362708662707e-12 8.825529486353001e-12 7.614578286490035e-12 2.4219023997259308e-12 0 0 0 0 K03633 0.0 0.0142450142450142 mukF; chromosome partition protein MukF 435.0 5.0 0.0 1.0 1.0 D 0.0 5.0 1.0 1.0 COG3006 Chromosome_condensin_MukBEF,_kleisin-like_MukF_subunit MukF 5.0 0.0 1.0 3.54973359337596e-21 3.38368821603793e-17 1.692021594698634e-17 3.3833332426785915e-17 0 0 0 0 K03634 0.0 0.3190883190883191 lolA; outer membrane lipoprotein carrier protein 7.0 128.0 126.0 4.0 0.96969696969697 M 0.0 129.0 3.0 0.962121212121212 COG2834 Outer_membrane_lipoprotein-sorting_protein LolA 129.0 0.0 1.0 0.0635044368194043 0.0151303561802161 0.0393173964998102 0.0483740806391882 0 0 0 0 K03635 0.4971428571428571 0.5156695156695157 MOCS2B, moaE; molybdopterin synthase catalytic subunit [EC:2.8.1.12] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 40.0 423.0 421.0 2.0 0.995294117647059 H 204.0 213.0 5.0 0.889411764705882 COG0314 Molybdopterin_synthase_catalytic_subunit_MoaE MoaE 417.0 0.4892086330935252 0.5107913669064749 0.0682987716649364 0.187236640495455 0.1277677060801957 0.1189378688305185 0 0 0 0 K03636 0.5028571428571429 0.5213675213675214 moaD, cysO; sulfur-carrier protein path:map04122 Sulfur relay system 10.0 673.0 672.0 2.0 0.998516320474777 H 386.0 288.0 7.0 0.968842729970326 COG1977 Molybdopterin_synthase_sulfur_carrier_subunit_MoaD MoaD 674.0 0.5727002967359051 0.4272997032640949 0.357383823578727 0.745270240602947 0.551327032090837 0.38788641702422 0 0 0 0 K03637 0.5657142857142857 0.6581196581196581 moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 109.0 449.0 444.0 2.0 0.988986784140969 H 201.0 253.0 6.0 0.964757709251101 COG0315 Molybdenum_cofactor_biosynthesis_enzyme_MoaC MoaC 454.0 0.4427312775330396 0.5572687224669604 0.126116972205689 0.534711734660521 0.330414353433105 0.408594762454832 0 0 0 0 K03638 0.5314285714285715 0.2507122507122507 moaB; molybdopterin adenylyltransferase [EC:2.7.7.75] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 118.0 293.0 0.0 1.0 1.0 H 203.0 90.0 1.0 1.0 COG0521 Molybdopterin_biosynthesis_enzyme_MoaB/MogA MoaB 293.0 0.6928327645051194 0.3071672354948805 0.007642803801987 0.224667651192857 0.116155227497422 0.21702484739087 0 0 0 0 K03639 0.5771428571428572 0.6695156695156695 moaA, CNX2; GTP 3',8-cyclase [EC:4.1.99.22] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 106.0 475.0 466.0 4.0 0.977366255144033 H 214.0 272.0 2.0 0.979423868312757 COG2896 GTP_3',8-cyclase_(molybdenum_cofactor_biosynthesis_protein_MoaA) MoaA 486.0 0.4403292181069959 0.5596707818930041 0.584997941158653 0.944803131565144 0.7649005363618985 0.3598051904064909 0 1 0 1 K03640 0.0 0.3988603988603988 pal; peptidoglycan-associated lipoprotein 60.0 162.0 154.0 3.0 0.941860465116279 M 0.0 172.0 3.0 0.941860465116279 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 172.0 0.0 1.0 0.0014792651369562 0.0091105635828504 0.0052949143599033 0.0076312984458942 0 0 0 0 K03641 0.0 0.0 tolB; TolB protein 231.0 209.0 11.0 0.777777777777778 U 0.0 0.0 11.0 0.851485148514852 COG0823 Periplasmic_component_TolB_of_the_Tol_biopolymer_transport_system TolB 0.0 0 0 0 0 K03642 0.0 0.4985754985754986 rlpA; rare lipoprotein A 43.0 202.0 190.0 7.0 0.848739495798319 M 0.0 238.0 13.0 0.84453781512605 COG0797 Peptidoglycan_lytic_transglycosylase_RlpA,_contains_C-terminal_SPOR_domain RlpA 238.0 0.0 1.0 0.0042430696932016 0.0624777377751916 0.0333604037341965 0.0582346680819899 0 0 0 0 K03643 0.0 0.2051282051282051 lptE, rlpB; LPS-assembly lipoprotein 20.0 47.0 22.0 2.0 0.652777777777778 M 0.0 72.0 2.0 0.652777777777778 COG2980 Outer_membrane_lipoprotein_LptE/RlpB_(LPS_assembly) LptE 72.0 0.0 1.0 0.0059148314391267 0.0130538963713834 0.009484363905255 0.0071390649322567 0 0 0 0 K03644 0.2714285714285714 0.698005698005698 lipA, LIAS, LIP1, LIP5; lipoyl synthase [EC:2.8.1.8] path:map00785,path:map01100,path:map01240 Lipoic acid metabolism,Metabolic pathways,Biosynthesis of cofactors 193.0 391.0 0.0 1.0 1.0 H 109.0 282.0 2.0 0.956521739130435 COG0320 Lipoate_synthase LipA 391.0 0.278772378516624 0.7212276214833759 0.0523154916375186 0.0555285997635141 0.0539220457005163 0.0032131081259954 0 0 0 0 K03645 0.0 0.0227920227920227 seqA; negative modulator of initiation of replication 151.0 8.0 0.0 1.0 1.0 L 0.0 8.0 1.0 1.0 COG3057 Negative_regulator_of_replication_initiation_SeqA SeqA 8.0 0.0 1.0 3.4540054328689097e-12 6.5363986529776195e-12 4.995202042923265e-12 3.0823932201087106e-12 0 0 0 0 K03646 0.0714285714285714 0.2393162393162393 tolA; colicin import membrane protein 5.0 75.0 63.0 11.0 0.663716814159292 M 25.0 110.0 18.0 0.384057971014493 COG0810 Periplasmic_protein_TonB,_links_inner_and_outer_membranes TonB 135.0 0.1851851851851851 0.8148148148148148 0.0219457891802363 0.0245795588520174 0.0232626740161268 0.0026337696717811 0 0 0 0 K03647 0.0 0.0854700854700854 nrdI; protein involved in ribonucleotide reduction 103.0 30.0 28.0 2.0 0.9375 F 0.0 32.0 2.0 0.9375 COG1780 Flavodoxin_NrdI,_NrdF-interacting_activator_of_class_Ib_ribonucleotide_reductase NrdI 32.0 0.0 1.0 0.0173827993339415 0.0326781697388381 0.0250304845363898 0.0152953704048966 0 0 0 0 K03648 0.02 0.4074074074074074 UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27] path:map03410,path:map05340 Base excision repair,Primary immunodeficiency 134.0 156.0 0.0 1.0 1.0 L 7.0 149.0 2.0 0.916666666666667 COG0692 Uracil-DNA_glycosylase Ung 156.0 0.0448717948717948 0.9551282051282052 0.0071914611338304 0.0208080085696913 0.0139997348517608 0.0136165474358609 0 0 0 0 K03649 0.0514285714285714 0.1538461538461538 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28] path:map03410 Base excision repair 69.0 75.0 0.0 1.0 1.0 L 18.0 57.0 1.0 1.0 COG3663 G:T/U-mismatch_repair_DNA_glycosylase Mug 75.0 0.24 0.76 0.021537403105017 0.0358557885265428 0.0286965958157799 0.0143183854215258 0 0 0 0 K03650 0.0 0.7749287749287749 mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-] 243.0 173.0 54.0 2.0 0.592465753424658 J 0.0 292.0 1.0 1.0 COG0486 tRNA_U34_5-carboxymethylaminomethyl_modifying_GTPase_MnmE/TrmE MnmE 292.0 0.0 1.0 0.255347159364346 0.131261763389698 0.193304461377022 0.1240853959746479 0 0 0 0 K03651 0.0171428571428571 0.2222222222222222 cpdA; 3',5'-cyclic-AMP phosphodiesterase [EC:3.1.4.53] path:map00230,path:map01100,path:map02025 Purine metabolism,Metabolic pathways,Biofilm formation - Pseudomonas aeruginosa 18.0 91.0 84.0 8.0 0.805309734513274 S 7.0 106.0 4.0 0.946902654867257 COG1409 3',5'-cyclic_AMP_phosphodiesterase_CpdA CpdA 113.0 0.0619469026548672 0.9380530973451328 0.0058864396792331 0.0416116475660438 0.0237490436226384 0.0357252078868106 0 0 0 0 K03652 0.1657142857142857 0.3418803418803419 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] path:map03410 Base excision repair 98.0 182.0 181.0 2.0 0.994535519125683 L 58.0 125.0 3.0 0.983606557377049 COG2094 3-methyladenine_DNA_glycosylase_Mpg Mpg 183.0 0.3169398907103825 0.6830601092896175 0.237949927090641 0.850418784419122 0.5441843557548816 0.612468857328481 0 0 0 0 K03653 0.3257142857142857 0.0541310541310541 K03653; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 122.0 135.0 0.0 1.0 1.0 L 116.0 19.0 1.0 1.0 COG1059 Thermostable_8-oxoguanine_DNA_glycosylase ENDO3c 135.0 0.8592592592592593 0.1407407407407407 0.964389938206059 0.901843592198662 0.9331167652023604 0.062546346007397 1 1 1 1 K03654 0.1057142857142857 0.6239316239316239 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] path:map03018 RNA degradation 130.0 404.0 391.0 6.0 0.955082742316785 L 45.0 374.0 11.0 0.912529550827423 COG0514 Superfamily_II_DNA_helicase_RecQ RecQ 419.0 0.107398568019093 0.8926014319809069 0.005134437517329 0.10231336490525 0.0537239012112895 0.097178927387921 0 0 0 0 K03655 0.22 0.9487179487179488 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] path:map03440 Homologous recombination 22.0 408.0 77.0 8.0 0.529182879377432 K 177.0 583.0 22.0 0.404617253948967 COG2865 Predicted_transcriptional_regulator,_contains_HTH_domain 760.0 0.2328947368421052 0.7671052631578947 0.0755950650509423 0.214848329520781 0.1452216972858616 0.1392532644698387 0 0 0 0 K03656 0.0 0.1566951566951566 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4] 489.0 58.0 0.0 1.0 1.0 L 0.0 58.0 2.0 0.982758620689655 COG0210 Superfamily_I_DNA_or_RNA_helicase UvrD 58.0 0.0 1.0 0.9853232452599 0.0668946931488212 0.5261089692043606 0.9184285521110788 0 0 1 1 K03657 0.5 0.9857549857549858 uvrD, pcrA; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] path:map03420,path:map03430 Nucleotide excision repair,Mismatch repair 27.0 924.0 920.0 5.0 0.992481203007519 L 231.0 730.0 17.0 0.833677685950413 COG0210 Superfamily_I_DNA_or_RNA_helicase UvrD 961.0 0.2403746097814776 0.7596253902185224 0.057486415985581 0.731748983869599 0.39461769992759 0.674262567884018 0 0 0 0 K03658 0.14 0.0427350427350427 helD; DNA helicase IV [EC:5.6.2.4] 56.0 101.0 96.0 2.0 0.952830188679245 L 85.0 18.0 6.0 0.556603773584906 COG1599 ssDNA-binding_replication_factor_A,_large_subunit RFA1 103.0 0.8252427184466019 0.174757281553398 0.593696093010951 0.958644376468589 0.7761702347397701 0.3649482834576379 0 1 0 1 K03660 0.3628571428571429 0.0968660968660968 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] path:map03410 Base excision repair 148.0 163.0 162.0 2.0 0.99390243902439 L 130.0 34.0 2.0 0.99390243902439 COG0122 3-methyladenine_DNA_glycosylase/8-oxoguanine_DNA_glycosylase AlkA 164.0 0.7926829268292683 0.2073170731707317 0.959184543034239 0.265121009115757 0.612152776074998 0.694063533918482 1 1 1 1 K03661 0.0028571428571428 0.0 ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit path:map00190,path:map01100,path:map04142,path:map04145,path:map04721,path:map05110,path:map05120,path:map05152,path:map05165,path:map05323 Oxidative phosphorylation,Metabolic pathways,Lysosome,Phagosome,Synaptic vesicle cycle,Vibrio cholerae infection,Epithelial cell signaling in Helicobacter pylori infection,Tuberculosis,Human papillomavirus infection,Rheumatoid arthritis 158.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG0636 FoF1-type_ATP_synthase,_membrane_subunit_c/Archaeal/vacuolar-type_H+-ATPase,_subunit_K AtpE 1.0 1.0 0.0 0 0 0 0 K03664 0.0 0.9829059829059827 smpB; SsrA-binding protein 117.0 205.0 63.0 2.0 0.590778097982709 O 0.0 347.0 1.0 1.0 COG0691 tmRNA-binding_protein SmpB 347.0 0.0 1.0 0.0621196895256968 0.595278321116214 0.3286990053209554 0.5331586315905172 0 0 0 0 K03665 0.4714285714285714 0.8148148148148148 hflX; GTPase 180.0 473.0 448.0 5.0 0.942231075697211 S 189.0 313.0 3.0 0.964143426294821 COG2262 50S_ribosomal_subunit-associated_GTPase_HflX HflX 502.0 0.3764940239043824 0.6235059760956175 0.117162771260389 0.320791088120298 0.2189769296903435 0.203628316859909 0 0 0 0 K03666 0.0114285714285714 0.3333333333333333 hfq; host factor-I protein path:map02024,path:map03018,path:map05111 Quorum sensing,RNA degradation,Biofilm formation - Vibrio cholerae 51.0 86.0 44.0 2.0 0.671875 J 4.0 124.0 1.0 1.0 COG1923 sRNA-binding_regulator_protein_Hfq Hfq 128.0 0.03125 0.96875 0.0236762046852969 0.0209052747736604 0.0222907397294786 0.0027709299116364 0 0 0 0 K03667 0.0 0.4843304843304843 hslU; ATP-dependent HslUV protease ATP-binding subunit HslU 382.0 173.0 0.0 1.0 1.0 O 0.0 173.0 1.0 1.0 COG1220 ATP-dependent_protease_HslVU_(ClpYQ),_ATPase_subunit_HslU HslU 173.0 0.0 1.0 0.0106476731979843 0.763864275002554 0.3872559741002692 0.7532166018045697 0 0 0 0 K03668 0.0 0.1139601139601139 hslJ; heat shock protein HslJ 32.0 41.0 40.0 3.0 0.953488372093023 O 0.0 43.0 3.0 0.953488372093023 COG3187 Heat_shock_protein_HslJ HslJ 43.0 0.0 1.0 0.059712463088044 0.200536365067562 0.130124414077803 0.140823901979518 0 0 0 0 K03669 0.0 0.1054131054131054 mdoH; membrane glycosyltransferase [EC:2.4.1.-] 470.0 36.0 0.0 1.0 1.0 M 0.0 39.0 2.0 0.923076923076923 COG2943 Membrane_glycosyltransferase MdoH 39.0 0.0 1.0 0.0075490678683768 0.013499362893317 0.0105242153808468 0.0059502950249402 0 0 0 0 K03670 0.0 0.0883190883190883 mdoG; periplasmic glucans biosynthesis protein 374.0 44.0 0.0 1.0 1.0 P 0.0 44.0 1.0 1.0 COG3131 Periplasmic_glucan_biosynthesis_protein_OpgG MdoG 44.0 0.0 1.0 0.0163800205668148 0.0601960863638388 0.0382880534653268 0.043816065797024 0 0 0 0 K03671 0.0 0.0 trxA; thioredoxin 1 path:map04621,path:map05012,path:map05132,path:map05418 NOD-like receptor signaling pathway,Parkinson disease,Salmonella infection,Fluid shear stress and atherosclerosis 1096.0 958.0 6.0 0.874700718276137 O 0.0 0.0 8.0 0.536624203821656 COG3118 Chaperedoxin_CnoX,_contains_thioredoxin-like_and_TPR-like_domains,_YbbN/TrxSC_family CnoX 0.0 0 0 0 0 K03672 0.0685714285714285 0.2307692307692307 trxC; thioredoxin 2 [EC:1.8.1.8] 58.0 102.0 88.0 2.0 0.879310344827586 O 25.0 91.0 2.0 0.698275862068966 COG3118 Chaperedoxin_CnoX,_contains_thioredoxin-like_and_TPR-like_domains,_YbbN/TrxSC_family CnoX 116.0 0.2155172413793103 0.7844827586206896 0.057497213103388 0.0755906128569038 0.0665439129801458 0.0180933997535158 0 0 0 0 K03673 0.0085714285714285 0.1139601139601139 dsbA; protein dithiol oxidoreductase (disulfide-forming) [EC:1.8.4.15] path:map01503 Cationic antimicrobial peptide (CAMP) resistance 75.0 43.0 39.0 4.0 0.86 O 3.0 47.0 2.0 0.96 COG1651 Protein_thiol-disulfide_isomerase_DsbC DsbG 50.0 0.06 0.94 0.0084967980868138 0.0110971753940965 0.0097969867404551 0.0026003773072826 0 0 0 0 K03674 0.0 0.0199430199430199 grxA; glutaredoxin 1 79.0 7.0 0.0 1.0 1.0 O 0.0 7.0 1.0 1.0 COG0695 Glutaredoxin GrxC 7.0 0.0 1.0 4.30222370849822e-11 6.1294921271826e-09 3.0862571821337913e-09 6.086469890097618e-09 0 0 0 0 K03675 0.0 0.0199430199430199 grxB; glutaredoxin 2 197.0 8.0 0.0 1.0 1.0 O 0.0 8.0 2.0 0.875 COG2999 Glutaredoxin_2 GrxB 8.0 0.0 1.0 0.0667872804206187 0.133311554230089 0.1000494173253538 0.0665242738094703 0 0 0 0 K03676 0.0657142857142857 0.301994301994302 grxC, GLRX, GLRX2; glutaredoxin 3 54.0 140.0 133.0 3.0 0.939597315436242 O 23.0 126.0 3.0 0.979865771812081 COG0695 Glutaredoxin GrxC 149.0 0.1543624161073825 0.8456375838926175 0.642976171072209 0.439332095865437 0.541154133468823 0.2036440752067719 0 1 0 1 K03679 0.8028571428571428 0.0 RRP4, EXOSC2; exosome complex component RRP4 path:map03018 RNA degradation 131.0 286.0 0.0 1.0 1.0 J 286.0 0.0 1.0 1.0 COG1097 Exosome_complex_RNA-binding_protein_Rrp4,_contains_S1_and_KH_domains Rrp4 286.0 1.0 0.0 0.769102624024129 0.0779068829046096 0.4235047534643693 0.6911957411195194 0 0 1 1 K03680 0.2428571428571428 0.0284900284900284 EIF2B4; translation initiation factor eIF-2B subunit delta path:map05168 Herpes simplex virus 1 infection 185.0 96.0 0.0 1.0 1.0 J 86.0 10.0 1.0 1.0 COG1184 Translation_initiation_factor_2B_subunit,_eIF-2B_alpha/beta/delta_family GCD2 96.0 0.8958333333333334 0.1041666666666666 0.366986360219408 0.0182957384447789 0.1926410493320934 0.3486906217746291 0 0 0 0 K03683 0.0 0.0541310541310541 rnt; ribonuclease T [EC:3.1.13.-] 200.0 18.0 17.0 2.0 0.947368421052632 L 0.0 19.0 1.0 1.0 COG0847 DNA_polymerase_III,_epsilon_subunit_or_related_3'-5'_exonuclease DnaQ 19.0 0.0 1.0 0.0040024686704161 0.0086558748304844 0.0063291717504502 0.0046534061600682 0 0 0 0 K03684 0.0171428571428571 0.4074074074074074 rnd; ribonuclease D [EC:3.1.13.5] 94.0 134.0 83.0 3.0 0.716577540106952 J 6.0 179.0 2.0 0.989304812834225 COG0349 Ribonuclease_D Rnd 185.0 0.0324324324324324 0.9675675675675676 0.0054681983536133 0.0371546833867146 0.0213114408701639 0.0316864850331013 0 0 0 0 K03685 0.0742857142857142 0.9487179487179488 rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3] path:map03008,path:map05205 Ribosome biogenesis in eukaryotes,Proteoglycans in cancer 80.0 303.0 230.0 5.0 0.799472295514512 J 29.0 350.0 3.0 0.994722955145119 COG0571 dsRNA-specific_ribonuclease Rnc 379.0 0.0765171503957783 0.9234828496042216 0.525461492182906 0.811780534742819 0.6686210134628625 0.2863190425599129 0 1 0 1 K03686 0.5971428571428572 0.9715099715099716 dnaJ; molecular chaperone DnaJ 78.0 783.0 775.0 4.0 0.986146095717884 O 282.0 516.0 5.0 0.963704630788486 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 798.0 0.3533834586466165 0.6466165413533834 0.396274073729559 0.219413488742463 0.3078437812360109 0.1768605849870959 0 0 0 0 K03687 0.6028571428571429 0.9829059829059827 GRPE; molecular chaperone GrpE 21.0 595.0 590.0 3.0 0.990016638935108 O 221.0 379.0 1.0 1.0 COG0576 Molecular_chaperone_GrpE_(heat_shock_protein_HSP-70) GrpE 600.0 0.3683333333333333 0.6316666666666667 0.0254035179182068 0.0644313310192169 0.0449174244687118 0.0390278131010101 0 0 0 0 K03688 0.1657142857142857 0.4045584045584046 ubiB, aarF; ubiquinone biosynthesis protein 199.0 207.0 191.0 4.0 0.892241379310345 S 67.0 165.0 1.0 1.0 COG0661 Predicted_protein_kinase_regulating_ubiquinone_biosynthesis,_AarF/ABC1/UbiB_family AarF 232.0 0.2887931034482758 0.7112068965517241 0.0097690227852965 0.227750518416647 0.1187597706009717 0.2179814956313505 0 0 0 0 K03689 0.0 0.0113960113960113 petN; cytochrome b6-f complex subunit 8 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 29.0 3.0 2.0 2.0 0.75 C 0.0 4.0 3.0 0.5 2DR6M 4.0 0.0 1.0 3.26929262118016e-05 3.27635426688828e-05 3.27282344403422e-05 7.06164570812005e-08 0 0 0 0 K03690 0.0 0.0683760683760683 ubiJ; ubiquinone biosynthesis accessory factor UbiJ 148.0 25.0 0.0 1.0 1.0 S 0.0 25.0 1.0 1.0 COG3165 Ubiquinone_biosynthesis_protein_UbiJ,_contains_SCP2_domain UbiJ 25.0 0.0 1.0 0.0015306628223989 0.0027750147478607 0.0021528387851298 0.0012443519254618 0 0 0 0 K03692 0.0 0.0256410256410256 E2.4.1.213; glucosylglycerol-phosphate synthase [EC:2.4.1.213] 450.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG0380 Trehalose-6-phosphate_synthase,_GT20_family OtsA 9.0 0.0 1.0 0.0399795113374188 0.0876120186034925 0.0637957649704556 0.0476325072660737 0 0 0 0 K03693 0.0 0.0427350427350427 pbp1b; penicillin-binding protein 1B path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 579.0 18.0 0.0 1.0 1.0 M 0.0 18.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 18.0 0.0 1.0 0.0018236812233825 0.0035407017359213 0.0026821914796519 0.0017170205125388 0 0 0 0 K03694 0.0085714285714285 0.3190883190883191 clpA; ATP-dependent Clp protease ATP-binding subunit ClpA 625.0 128.0 127.0 2.0 0.992248062015504 O 3.0 126.0 1.0 1.0 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 129.0 0.0232558139534883 0.9767441860465116 0.031883497779127 0.72263415599323 0.3772588268861785 0.690750658214103 0 0 0 0 K03695 0.0828571428571428 0.8233618233618234 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB path:map04213 Longevity regulating pathway - multiple species 648.0 383.0 0.0 1.0 1.0 O 32.0 351.0 2.0 0.992167101827676 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 383.0 0.0835509138381201 0.91644908616188 0.0284707063867525 0.762583220835716 0.3955269636112342 0.7341125144489634 0 0 0 0 K03696 0.04 0.7065527065527065 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC 513.0 404.0 395.0 3.0 0.975845410628019 O 15.0 399.0 2.0 0.978260869565217 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 414.0 0.036231884057971 0.9637681159420288 0.546928119404041 0.981376118663615 0.764152119033828 0.434447999259574 0 1 0 1 K03697 0.0 0.0484330484330484 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE 609.0 17.0 0.0 1.0 1.0 O 0.0 17.0 1.0 1.0 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 17.0 0.0 1.0 0.0270707665796741 0.312202923926216 0.169636845252945 0.2851321573465419 0 0 0 0 K03698 0.0828571428571428 0.2678062678062678 cbf, cbf1; 3'-5' exoribonuclease [EC:3.1.-.-] 119.0 108.0 100.0 6.0 0.805970149253731 S 30.0 104.0 3.0 0.985074626865672 COG3481 3'-5'_exoribonuclease_YhaM,_can_participate_in_23S_rRNA_maturation,__HD_superfamily YhaM 134.0 0.2238805970149253 0.7761194029850746 0.800292390808234 0.929810400489516 0.865051395648875 0.129518009681282 1 1 1 1 K03699 0.0914285714285714 0.5669515669515669 tlyC; magnesium and cobalt exporter, CNNM family 179.0 224.0 174.0 5.0 0.751677852348993 S 34.0 264.0 5.0 0.912751677852349 COG1253 Hemolysin-related_protein,_contains_CBS_domains,_UPF0053_family TlyC 298.0 0.1140939597315436 0.8859060402684564 0.0492331748157702 0.920670981740752 0.4849520782782611 0.8714378069249819 0 0 0 0 K03700 0.0 0.074074074074074 recU; recombination protein U 141.0 27.0 0.0 1.0 1.0 L 0.0 27.0 1.0 1.0 COG3331 Penicillin-binding_protein-related_factor_A,_putative_recombinase YotM 27.0 0.0 1.0 0.0098673314776448 0.0232823408189391 0.0165748361482919 0.0134150093412942 0 0 0 0 K03701 0.3885714285714285 0.9743589743589745 uvrA; excinuclease ABC subunit A path:map03420 Nucleotide excision repair 685.0 606.0 0.0 1.0 1.0 L 149.0 457.0 1.0 1.0 COG0178 Excinuclease_UvrABC_ATPase_subunit UvrA 606.0 0.2458745874587458 0.7541254125412541 0.715899726969168 0.800375428535633 0.7581375777524005 0.084475701566465 0 1 0 1 K03702 0.3885714285714285 0.9686609686609686 uvrB; excinuclease ABC subunit B path:map03420 Nucleotide excision repair 533.0 486.0 484.0 2.0 0.995901639344262 L 137.0 351.0 1.0 1.0 COG0556 Excinuclease_UvrABC_helicase_subunit_UvrB UvrB 488.0 0.2807377049180328 0.7192622950819673 0.0170369930923898 0.0727183639018298 0.0448776784971098 0.0556813708094399 0 0 0 0 K03703 0.3942857142857143 0.9829059829059827 uvrC; excinuclease ABC subunit C path:map03420 Nucleotide excision repair 183.0 527.0 522.0 3.0 0.98689138576779 L 159.0 375.0 4.0 0.955056179775281 COG0322 Excinuclease_UvrABC,_nuclease_subunit UvrC 534.0 0.297752808988764 0.702247191011236 0.396327386828123 0.0958115409160204 0.2460694638720717 0.3005158459121026 0 0 0 0 K03704 0.3342857142857143 0.7321937321937322 cspA; cold shock protein 6.0 956.0 953.0 4.0 0.992731048805815 K 280.0 681.0 3.0 0.994807892004154 COG1278 Cold_shock_protein,_CspA_family CspC 961.0 0.291363163371488 0.708636836628512 0.0093725384105563 0.0093725384105563 0 0 0 0 K03705 0.0 0.698005698005698 hrcA; heat-inducible transcriptional repressor 143.0 247.0 0.0 1.0 1.0 K 0.0 247.0 1.0 1.0 COG1420 Transcriptional_regulator_of_heat_shock_response HrcA 247.0 0.0 1.0 0.302892257600981 0.347085400528543 0.324988829064762 0.0441931429275619 0 0 0 0 K03706 0.0 0.0968660968660968 codY; transcriptional pleiotropic repressor 224.0 36.0 0.0 1.0 1.0 K 0.0 36.0 1.0 1.0 COG4465 GTP-sensing_pleiotropic_transcriptional_regulator_CodY CodY 36.0 0.0 1.0 0.0040647883436804 0.0071222126408575 0.0055935004922689 0.0030574242971771 0 0 0 0 K03707 0.1542857142857142 0.1908831908831909 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 113.0 149.0 140.0 3.0 0.937106918238994 K 78.0 81.0 2.0 0.949685534591195 COG0819 Aminopyrimidine_aminohydrolase_TenA_(thiamine_salvage_pathway) TenA 159.0 0.490566037735849 0.5094339622641509 0.0044345205457627 0.544147266098392 0.2742908933220773 0.5397127455526294 0 0 0 0 K03708 0.0 0.1111111111111111 ctsR; transcriptional regulator of stress and heat shock response 127.0 39.0 0.0 1.0 1.0 K 0.0 39.0 1.0 1.0 COG4463 Transcriptional_regulator_CtsR CtsR 39.0 0.0 1.0 0.0017459065222625 0.0041455414009212 0.0029457239615918 0.0023996348786587 0 0 0 0 K03709 0.6914285714285714 0.452991452991453 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 33.0 608.0 590.0 5.0 0.952978056426332 K 411.0 222.0 5.0 0.982758620689655 COG1321 Mn-dependent_transcriptional_regulator_MntR,_DtxR_family MntR 633.0 0.6492890995260664 0.3507109004739336 0.422672983669907 0.668751550315178 0.5457122669925425 0.2460785666452709 0 0 0 0 K03710 0.0028571428571428 0.3903133903133903 K03710; GntR family transcriptional regulator 23.0 328.0 323.0 2.0 0.984984984984985 K 1.0 329.0 4.0 0.975975975975976 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 330.0 0.003030303030303 0.996969696969697 0.0134097776178583 0.555309020101382 0.2843593988596201 0.5418992424835236 0 0 0 0 K03711 0.1314285714285714 0.811965811965812 fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator 30.0 440.0 310.0 3.0 0.767888307155323 P 52.0 517.0 2.0 0.994764397905759 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 569.0 0.0913884007029877 0.9086115992970124 0.0087161708540037 0.557537712490365 0.2831269416721843 0.5488215416363613 0 0 0 0 K03712 0.0 0.0085470085470085 marR; MarR family transcriptional regulator, multiple antibiotic resistance protein MarR 120.0 3.0 0.0 1.0 1.0 K 0.0 3.0 2.0 0.666666666666667 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 3.0 0.0 1.0 0 0 0 0 K03713 0.0 0.0541310541310541 glnR; MerR family transcriptional regulator, glutamine synthetase repressor 100.0 20.0 0.0 1.0 1.0 K 0.0 20.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 20.0 0.0 1.0 0.0025566554082547 0.0067000213018079 0.0046283383550313 0.0041433658935532 0 0 0 0 K03715 0.0 0.0256410256410256 MGD; 1,2-diacylglycerol 3-beta-galactosyltransferase [EC:2.4.1.46] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 344.0 9.0 0.0 1.0 1.0 M 0.0 9.0 1.0 1.0 COG0707 UDP-N-acetylglucosamine:LPS_N-acetylglucosamine_transferase MurG 9.0 0.0 1.0 0.0797439226998886 0.906979194495411 0.4933615585976498 0.8272352717955224 0 0 0 0 K03716 0.0314285714285714 0.1937321937321937 splB; spore photoproduct lyase [EC:4.1.99.14] 102.0 79.0 71.0 2.0 0.908045977011494 L 11.0 76.0 2.0 0.908045977011494 COG1533 DNA_repair_photolyase SplB 87.0 0.1264367816091954 0.8735632183908046 0.88340455697191 0.991877110627922 0.937640833799916 0.108472553656012 1 1 1 1 K03717 0.0 0.0883190883190883 nhaR; LysR family transcriptional regulator, transcriptional activator of nhaA 253.0 36.0 0.0 1.0 1.0 K 0.0 36.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 36.0 0.0 1.0 0.0089224024795626 0.0600081014869371 0.0344652519832498 0.0510856990073745 0 0 0 0 K03718 0.7257142857142858 0.188034188034188 asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA 45.0 615.0 0.0 1.0 1.0 K 517.0 98.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 615.0 0.8406504065040651 0.1593495934959349 0.273020790456286 0.914681095882791 0.5938509431695385 0.641660305426505 0 0 0 0 K03719 0.1657142857142857 0.3846153846153846 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein 82.0 336.0 0.0 1.0 1.0 K 75.0 261.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 336.0 0.2232142857142857 0.7767857142857143 0.0002393521841485 0.0050966841334527 0.0026680181588006 0.0048573319493042 0 0 0 0 K03720 0.0 0.0455840455840455 trpR; TrpR family transcriptional regulator, trp operon repressor 73.0 12.0 8.0 2.0 0.75 K 0.0 16.0 2.0 0.75 COG2973 Trp_operon_repressor TrpR 16.0 0.0 1.0 0.666848686396441 0.0414553026686082 0.3541519945325246 0.6253933837278328 0 0 0 1 K03721 0.0 0.0484330484330484 tyrR; transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport 285.0 41.0 21.0 3.0 0.630769230769231 KT 0.0 65.0 5.0 0.8 COG3829 RocR-type_transcriptional_regulator,_contains_PAS,_AAA-type_ATPase,_and_DNA-binding_Fis_domains RocR 65.0 0.0 1.0 0.0006256449113866 0.0018095191262096 0.0012175820187981 0.0011838742148229 0 0 0 0 K03722 0.1314285714285714 0.5156695156695157 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3] 157.0 124.0 16.0 6.0 0.462686567164179 KL 55.0 213.0 6.0 0.914179104477612 COG1199 Rad3-related_DNA_helicase_DinG DinG 268.0 0.2052238805970149 0.7947761194029851 0.0346137375868808 0.874992038915132 0.4548028882510064 0.8403783013282512 0 0 0 0 K03723 0.0028571428571428 0.9031339031339032 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] path:map03420 Nucleotide excision repair 550.0 327.0 326.0 2.0 0.996951219512195 L 1.0 327.0 1.0 1.0 COG1197 Transcription-repair_coupling_factor_(superfamily_II_helicase) Mfd 328.0 0.0030487804878048 0.9969512195121952 0.778779174368507 0.40788700769948 0.5933330910339935 0.3708921666690269 0 0 1 1 K03724 0.8628571428571429 0.3133903133903133 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:3.6.4.13 5.6.2.4] 241.0 545.0 369.0 3.0 0.751724137931034 L 575.0 143.0 7.0 0.878620689655172 COG1201 Lhr-like_helicase Lhr 718.0 0.8008356545961003 0.1991643454038997 0.554386776857179 0.913657044157036 0.7340219105071075 0.359270267299857 0 1 0 1 K03725 0.2828571428571428 0.0 K03725; putative ATP-dependent RNA helicase [EC:3.6.4.-] 551.0 101.0 96.0 2.0 0.952830188679245 L 106.0 0.0 1.0 1.0 COG1202 Superfamily_II_helicase,_archaea-specific 106.0 1.0 0.0 0.949242643088725 0.871796337983451 0.910519490536088 0.0774463051052739 0 0 1 1 K03726 0.8 0.0313390313390313 helS; ATP-dependent DNA helicase [EC:5.6.2.4] 378.0 371.0 369.0 2.0 0.994638069705094 L 360.0 13.0 2.0 0.994638069705094 COG1204 Replicative_superfamily_II_helicase BRR2 373.0 0.96514745308311 0.03485254691689 0.972958005761922 0.989790216511878 0.9813741111369 0.016832210749956 1 1 1 1 K03727 0.0342857142857142 0.1139601139601139 helY; ATP-dependent RNA helicase HelY [EC:3.6.4.-] 491.0 53.0 0.0 1.0 1.0 L 12.0 41.0 3.0 0.943396226415094 COG4581 Superfamily_II_RNA_helicase Dob10 53.0 0.2264150943396226 0.7735849056603774 0.0098659204164291 0.0237307997299327 0.0167983600731809 0.0138648793135036 0 0 0 0 K03731 0.0028571428571428 0.0028490028490028 E2.4.1.216; trehalose 6-phosphate phosphorylase [EC:2.4.1.216] 777.0 2.0 0.0 1.0 1.0 G 1.0 1.0 2.0 0.5 COG1554 Kojibiose_phosphorylase_YcjT ATH1 2.0 0.5 0.5 0 0 0 0 K03732 0.0057142857142857 0.1709401709401709 rhlB; ATP-dependent RNA helicase RhlB [EC:3.6.4.13] path:map03018 RNA degradation 284.0 44.0 28.0 4.0 0.6875 L 2.0 62.0 3.0 0.9375 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 64.0 0.03125 0.96875 0.0172047576073815 0.0275487321441173 0.0223767448757494 0.0103439745367358 0 0 0 0 K03733 0.1828571428571428 0.8091168091168092 xerC; integrase/recombinase XerC 38.0 340.0 197.0 3.0 0.685483870967742 L 85.0 409.0 4.0 0.729838709677419 COG4974 Site-specific_recombinase_XerD XerD 494.0 0.1720647773279352 0.8279352226720648 0.349904460203733 0.811372446432844 0.5806384533182884 0.461467986229111 0 0 0 0 K03734 0.0514285714285714 0.5555555555555556 apbE; FAD:protein FMN transferase [EC:2.7.1.180] 72.0 283.0 280.0 3.0 0.986062717770035 H 18.0 269.0 4.0 0.97212543554007 COG1477 FAD:protein_FMN_transferase_ApbE ApbE 287.0 0.0627177700348432 0.9372822299651568 0.567723055886931 0.835241016573642 0.7014820362302865 0.2675179606867111 0 1 0 1 K03735 0.0085714285714285 0.1168091168091168 eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 426.0 47.0 0.0 1.0 1.0 E 3.0 44.0 3.0 0.829787234042553 COG4303 Ethanolamine_ammonia-lyase,_large_subunit EutB 47.0 0.0638297872340425 0.9361702127659576 0.0406980539126736 0.189851393337643 0.1152747236251583 0.1491533394249694 0 0 0 0 K03736 0.0085714285714285 0.1111111111111111 eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 198.0 39.0 36.0 2.0 0.928571428571429 E 3.0 39.0 2.0 0.928571428571429 COG4302 Ethanolamine_ammonia-lyase,_small_subunit EutC 42.0 0.0714285714285714 0.9285714285714286 0.0152124694402689 0.0509426122915065 0.0330775408658877 0.0357301428512376 0 0 0 0 K03737 0.0171428571428571 0.3333333333333333 por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] path:map00010,path:map00020,path:map00620,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 929.0 149.0 0.0 1.0 1.0 C 6.0 143.0 6.0 0.899328859060403 COG0674 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_alpha_subunit PorA 149.0 0.0402684563758389 0.959731543624161 0.0168064454695129 0.260222958641537 0.1385147020555249 0.2434165131720241 0 0 0 0 K03738 0.4514285714285714 0.1766381766381766 aor; aldehyde:ferredoxin oxidoreductase [EC:1.2.7.5] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 154.0 824.0 0.0 1.0 1.0 C 621.0 191.0 1.0 1.0 COG2414 Aldehyde:ferredoxin_oxidoreductase YdhV 812.0 0.7647783251231527 0.2352216748768472 0.876222610821211 0.929506418761081 0.902864514791146 0.0532838079398699 1 1 1 1 K03739 0.0 0.0398860398860398 dltB; membrane protein involved in D-alanine export path:map00552,path:map01503,path:map02020,path:map05150 Teichoic acid biosynthesis,Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Staphylococcus aureus infection 320.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG1696 D-alanyl-lipoteichoic_acid_acyltransferase_DltB,_MBOAT_superfamily DltB 15.0 0.0 1.0 0.035583567062621 0.0648034512805187 0.0501935091715698 0.0292198842178977 0 0 0 0 K03740 0.0 0.0227920227920227 dltD; D-alanine transfer protein path:map00552,path:map01503,path:map02020,path:map05150 Teichoic acid biosynthesis,Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Staphylococcus aureus infection 359.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG3966 Poly-D-alanine_transfer_protein_DltD,_involved_in_esterification_of_teichoic_acids DltD 8.0 0.0 1.0 0.0332695672128316 0.087206717420771 0.0602381423168013 0.0539371502079394 0 0 0 0 K03741 0.4028571428571428 0.5641025641025641 arsC; arsenate reductase (thioredoxin) [EC:1.20.4.4] 36.0 406.0 379.0 6.0 0.91647855530474 T 167.0 286.0 7.0 0.901315789473684 COG0394 Protein-tyrosine-phosphatase Wzb 453.0 0.3686534216335541 0.6313465783664459 0.0343663899972186 0.0749271311251832 0.0546467605612009 0.0405607411279646 0 0 0 0 K03742 0.0685714285714285 0.6125356125356125 pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 87.0 251.0 249.0 3.0 0.988188976377953 S 26.0 226.0 3.0 0.830708661417323 COG1058 ADP-ribose_pyrophosphatase_domain_of_DNA_damage-_and_competence-inducible_protein_CinA CinA 252.0 0.1031746031746031 0.8968253968253969 0.231232180231598 0.456108312886628 0.343670246559113 0.22487613265503 0 0 0 0 K03743 0.1914285714285714 0.6723646723646723 pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 65.0 307.0 300.0 4.0 0.965408805031446 S 70.0 247.0 4.0 0.572327044025157 COG1546 Nicotinamide_mononucleotide_(NMN)_deamidase_PncC PncC 317.0 0.2208201892744479 0.7791798107255521 0.150602904477239 0.0498836694589824 0.1002432869681107 0.1007192350182566 0 0 0 0 K03744 0.2428571428571428 0.5527065527065527 lemA; LemA protein 129.0 331.0 329.0 2.0 0.993993993993994 S 89.0 244.0 2.0 0.996996996996997 COG1704 Magnetosome_formation_protein_MamQ,_lipoprotein_antigen_LemA_family LemA 333.0 0.2672672672672673 0.7327327327327328 0.755017911055643 0.86011386369945 0.8075658873775464 0.105095952643807 1 1 1 1 K03745 0.0 0.1168091168091168 slyX; SlyX protein 55.0 41.0 0.0 1.0 1.0 S 0.0 41.0 4.0 0.902439024390244 COG2900 Uncharacterized_coiled-coil_protein_SlyX_(sensitive_to_lysis_X) SlyX 41.0 0.0 1.0 0.0033476184418216 0.008587306447767 0.0059674624447943 0.0052396880059454 0 0 0 0 K03746 0.0 0.0826210826210826 hns; DNA-binding protein H-NS 78.0 34.0 28.0 3.0 0.80952380952381 S 0.0 42.0 2.0 0.976190476190476 COG2916 DNA-binding_protein_H-NS Hns 42.0 0.0 1.0 0.0016997604155854 0.003818275320824 0.0027590178682047 0.0021185149052386 0 0 0 0 K03747 0.0 0.0683760683760683 smg; Smg protein 98.0 24.0 0.0 1.0 1.0 S 0.0 24.0 3.0 0.916666666666667 COG2922 Uncharacterized_conserved_protein_Smg,_DUF494_family Smg 24.0 0.0 1.0 0.003545933367814 0.114322135927399 0.0589340346476065 0.110776202559585 0 0 0 0 K03748 0.0 0.094017094017094 sanA; SanA protein 171.0 35.0 0.0 1.0 1.0 S 0.0 35.0 1.0 1.0 COG2949 Uncharacterized_periplasmic_protein_SanA,_affects_membrane_permeability_for_vancomycin SanA 35.0 0.0 1.0 0.0121474870056746 0.024201048036211 0.0181742675209428 0.0120535610305363 0 0 0 0 K03749 0.0 0.1225071225071225 dedD; DedD protein 42.0 28.0 12.0 5.0 0.583333333333333 S 0.0 48.0 7.0 0.583333333333333 COG3147 Cell_division_protein_DedD_(periplasmic_protein_involved_in_septation) DedD 48.0 0.0 1.0 0.0061746627971285 0.0129049150384867 0.0095397889178076 0.0067302522413581 0 0 0 0 K03750 0.5571428571428572 0.6552706552706553 moeA; molybdopterin molybdotransferase [EC:2.10.1.1] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 107.0 750.0 713.0 4.0 0.911300121506683 H 440.0 377.0 10.0 0.940461725394897 COG0303 Molybdopterin_Mo-transferase_(molybdopterin_biosynthesis) MoeA 817.0 0.5385556915544676 0.4614443084455324 0.142280228880033 0.729430630958939 0.435855429919486 0.587150402078906 0 0 0 0 K03752 0.4885714285714285 0.5441595441595442 mobA; molybdenum cofactor guanylyltransferase [EC:2.7.7.77] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 15.0 396.0 380.0 4.0 0.947368421052632 H 188.0 225.0 7.0 0.911483253588517 COG0746 Molybdopterin-guanine_dinucleotide_biosynthesis_protein_A MobA 413.0 0.4552058111380145 0.5447941888619855 0.0973349760095687 0.207624001780092 0.1524794888948303 0.1102890257705233 0 0 0 0 K03753 0.3457142857142857 0.2706552706552707 mobB; molybdopterin-guanine dinucleotide biosynthesis adapter protein 32.0 238.0 230.0 2.0 0.967479674796748 H 129.0 102.0 5.0 0.898373983739837 COG1763 Molybdopterin-guanine_dinucleotide_biosynthesis_protein MobB 231.0 0.5584415584415584 0.4415584415584415 0.546455858737317 0.425691248731249 0.4860735537342829 0.1207646100060679 0 1 0 1 K03755 0.0 0.0028490028490028 adiY; AraC family transcriptional regulator, transcriptional activator of adiA 253.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 2.0 0.0 1.0 0 0 0 0 K03756 0.0 0.0113960113960113 potE; putrescine:ornithine antiporter 436.0 7.0 0.0 1.0 1.0 E 0.0 7.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 7.0 0.0 1.0 0.0042082389854243 0.0106680824496606 0.0074381607175424 0.0064598434642362 0 0 0 0 K03757 0.0 0.0113960113960113 cadB; cadaverine:lysine antiporter 415.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 8.0 0.0 1.0 6.09074313878329e-12 3.20247274480552e-11 1.9057735293419243e-11 2.593398430927191e-11 0 0 0 0 K03758 0.0171428571428571 0.0854700854700854 arcD, lysl, lysP; arginine:ornithine antiporter / lysine permease 361.0 45.0 0.0 1.0 1.0 E 9.0 36.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 45.0 0.2 0.8 0.0411764572318851 0.025257574562789 0.033217015897337 0.0159188826690961 0 0 0 0 K03759 0.0 0.0113960113960113 adiC; arginine:agmatine antiporter 387.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 8.0 0.0 1.0 0.0064229499164716 0.0158596429583303 0.0111412964374009 0.0094366930418587 0 0 0 0 K03760 0.0 0.074074074074074 eptA, pmrC; lipid A ethanolaminephosphotransferase [EC:2.7.8.43] path:map00540,path:map01100,path:map01503 Lipopolysaccharide biosynthesis,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance 363.0 23.0 18.0 3.0 0.741935483870968 S 0.0 31.0 1.0 1.0 COG2194 Phosphoethanolamine_transferase_for_periplasmic_glucans_OpgE,_AlkP_superfamily OpgE 31.0 0.0 1.0 0.0075091857137087 0.0161552292035653 0.011832207458637 0.0086460434898566 0 0 0 0 K03761 0.0 0.0826210826210826 kgtP; MFS transporter, MHS family, alpha-ketoglutarate permease 371.0 36.0 33.0 2.0 0.923076923076923 EGP 0.0 39.0 2.0 0.923076923076923 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 39.0 0.0 1.0 0 0 0 0 K03762 0.0542857142857142 0.0911680911680911 proP; MFS transporter, MHS family, proline/betaine transporter 262.0 71.0 59.0 3.0 0.845238095238095 EGP 25.0 59.0 2.0 0.988095238095238 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 84.0 0.2976190476190476 0.7023809523809523 0 0 0 0 K03763 0.0 0.0 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 104.0 100.0 4.0 0.936936936936937 L 0.0 0.0 4.0 0.918918918918919 COG2176 DNA_polymerase_III,_alpha_subunit_(gram-positive_type) PolC 0.0 0 0 0 0 K03764 0.0 0.0199430199430199 metJ; MetJ family transcriptional regulator, methionine regulon repressor 102.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG3060 Transcriptional_regulator_MetJ_(met_regulon) MetJ 7.0 0.0 1.0 1.01134659960537e-21 4.52936874271502e-17 2.2647349386874907e-17 4.5292676080550586e-17 0 0 0 0 K03765 0.0 0.0227920227920227 cadC; transcriptional activator of cad operon 334.0 6.0 2.0 2.0 0.6 S 0.0 10.0 2.0 0.6 COG5616 TolB_amino-terminal_domain_(function_unknown) TolBN 10.0 0.0 1.0 0.0067571610311068 0.0251304099574643 0.0159437854942855 0.0183732489263575 0 0 0 0 K03767 0.2542857142857143 0.4558404558404558 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] path:map01503,path:map03250,path:map04217 Cationic antimicrobial peptide (CAMP) resistance,Viral life cycle - HIV-1,Necroptosis 46.0 251.0 202.0 4.0 0.799363057324841 O 102.0 212.0 5.0 0.904458598726115 COG0652 Peptidyl-prolyl_cis-trans_isomerase_(rotamase)_-_cyclophilin_family PpiB 314.0 0.3248407643312102 0.6751592356687898 0.0099074587559438 0.0458335809414986 0.0278705198487212 0.0359261221855548 0 0 0 0 K03768 0.4085714285714286 0.7037037037037037 PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] 33.0 477.0 414.0 7.0 0.831010452961672 O 188.0 386.0 8.0 0.942508710801394 COG0652 Peptidyl-prolyl_cis-trans_isomerase_(rotamase)_-_cyclophilin_family PpiB 574.0 0.3275261324041811 0.6724738675958188 0.0106694543724959 0.11881348246639 0.0647414684194429 0.108144028093894 0 0 0 0 K03769 0.0 0.0 ppiC; peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8] 192.0 85.0 3.0 0.60952380952381 O 0.0 0.0 2.0 0.996825396825397 COG0760 Peptidyl-prolyl_isomerase,_parvulin_family SurA 0.0 0 0 0 0 K03770 0.0085714285714285 0.5185185185185185 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] 17.0 212.0 197.0 3.0 0.925764192139738 O 3.0 220.0 3.0 0.991304347826087 COG0760 Peptidyl-prolyl_isomerase,_parvulin_family SurA 223.0 0.0134529147982062 0.9865470852017936 0.0015517414187025 0.0039807183807881 0.0027662298997453 0.0024289769620856 0 0 0 0 K03771 0.0085714285714285 0.4985754985754986 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] 6.0 173.0 95.0 2.0 0.689243027888446 O 3.0 241.0 5.0 0.968253968253968 COG0760 Peptidyl-prolyl_isomerase,_parvulin_family SurA 244.0 0.0122950819672131 0.9877049180327868 0.0269031355487579 0.0395977412323945 0.0332504383905762 0.0126946056836366 0 0 0 0 K03772 0.0114285714285714 0.3703703703703703 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8] 79.0 123.0 69.0 4.0 0.615 O 6.0 194.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 200.0 0.03 0.97 0.0054658596952023 0.0455029147748723 0.0254843872350373 0.0400370550796699 0 0 0 0 K03773 0.0 0.1908831908831909 fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] 89.0 55.0 18.0 4.0 0.572916666666667 O 0.0 96.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 96.0 0.0 1.0 0.011381587016838 0.0257351522518161 0.018558369634327 0.0143535652349781 0 0 0 0 K03774 0.0342857142857142 0.1225071225071225 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8] 109.0 46.0 37.0 2.0 0.836363636363636 O 12.0 43.0 2.0 0.981818181818182 COG1047 Peptidyl-prolyl_cis-trans_isomerase,_FKBP_type SlpA 55.0 0.2181818181818181 0.7818181818181819 0.0386340701608755 0.0432060903593803 0.0409200802601279 0.0045720201985047 0 0 0 0 K03775 0.66 0.282051282051282 slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] 70.0 368.0 330.0 3.0 0.904176904176904 O 284.0 122.0 3.0 0.995085995085995 COG1047 Peptidyl-prolyl_cis-trans_isomerase,_FKBP_type SlpA 406.0 0.6995073891625616 0.3004926108374384 0.683469577628763 0.4561332001147 0.5698013888717315 0.227336377514063 0 1 0 1 K03776 0.0057142857142857 0.1111111111111111 aer; aerotaxis receptor path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 71.0 48.0 23.0 3.0 0.558139534883721 NT 2.0 83.0 3.0 0.825581395348837 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 85.0 0.0235294117647058 0.976470588235294 0.0041681026411251 0.007624321724977 0.005896212183051 0.0034562190838519 0 0 0 0 K03777 0.0114285714285714 0.0626780626780626 dld; D-lactate dehydrogenase (quinone) [EC:1.1.5.12] path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 355.0 31.0 0.0 1.0 1.0 C 4.0 27.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 31.0 0.1290322580645161 0.8709677419354839 0.0314344771761318 0.0277160659407992 0.0295752715584655 0.0037184112353325 0 0 0 0 K03778 0.0828571428571428 0.2962962962962963 ldhA; D-lactate dehydrogenase [EC:1.1.1.28] path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 216.0 86.0 34.0 4.0 0.589041095890411 CH 29.0 117.0 2.0 0.945205479452055 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 146.0 0.1986301369863013 0.8013698630136986 0.0257218750397204 0.328318410937648 0.1770201429886842 0.3025965358979276 0 0 0 0 K03779 0.0714285714285714 0.0484330484330484 ttdA; L(+)-tartrate dehydratase alpha subunit [EC:4.2.1.32] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 271.0 44.0 0.0 1.0 1.0 C 27.0 17.0 2.0 0.931818181818182 COG1951 Tartrate_dehydratase_alpha_subunit/Fumarate_hydratase_class_I,_N-terminal_domain TtdA 44.0 0.6136363636363636 0.3863636363636363 0.0323837406514275 0.27253919131429 0.1524614659828587 0.2401554506628624 0 0 0 0 K03780 0.1257142857142857 0.1082621082621082 ttdB; L(+)-tartrate dehydratase beta subunit [EC:4.2.1.32] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 148.0 82.0 0.0 1.0 1.0 C 44.0 38.0 1.0 1.0 COG1838 Tartrate_dehydratase_beta_subunit/Fumarate_hydratase_class_I,_C-terminal_domain FumA 82.0 0.5365853658536586 0.4634146341463415 0.194453785548541 0.952604605142816 0.5735291953456785 0.758150819594275 0 0 0 0 K03781 0.0971428571428571 0.3247863247863248 katE, CAT, catB, srpA; catalase [EC:1.11.1.6] path:map00380,path:map00630,path:map01100,path:map01110,path:map01200,path:map04011,path:map04016,path:map04068,path:map04146,path:map04211,path:map04212,path:map04213,path:map05014,path:map05022,path:map05208 Tryptophan metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism,MAPK signaling pathway - yeast,MAPK signaling pathway - plant,FoxO signaling pathway,Peroxisome,Longevity regulating pathway,Longevity regulating pathway - worm,Longevity regulating pathway - multiple species,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species 390.0 126.0 37.0 4.0 0.580645161290323 P 41.0 176.0 2.0 0.857142857142857 COG0753 Catalase KatE 217.0 0.1889400921658986 0.8110599078341014 0.0321132574958285 0.207738283180064 0.1199257703379462 0.1756250256842355 0 0 0 0 K03782 0.1685714285714285 0.3133903133903133 katG; catalase-peroxidase [EC:1.11.1.21] path:map00360,path:map00380,path:map00940,path:map00983,path:map01100,path:map01110 Phenylalanine metabolism,Tryptophan metabolism,Phenylpropanoid biosynthesis,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of secondary metabolites 663.0 175.0 159.0 3.0 0.888324873096447 P 66.0 131.0 2.0 0.695431472081218 COG0376 Catalase_(peroxidase_I) KatG 197.0 0.3350253807106599 0.6649746192893401 0.0046630421118347 0.236160796137704 0.1204119191247693 0.2314977540258693 0 0 0 0 K03783 0.0285714285714285 0.4928774928774929 punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1] path:map00230,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 158.0 211.0 210.0 4.0 0.985981308411215 F 11.0 203.0 3.0 0.97196261682243 COG0005 Purine_nucleoside_phosphorylase XapA 214.0 0.0514018691588785 0.9485981308411215 0.365258716507179 0.584538741901079 0.474898729204129 0.2192800253939 0 0 0 0 K03784 0.02 0.2222222222222222 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] path:map00230,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 184.0 95.0 0.0 1.0 1.0 F 7.0 88.0 3.0 0.873684210526316 COG0813 Purine-nucleoside_phosphorylase DeoD 95.0 0.0736842105263157 0.9263157894736842 0.884592798727625 0.823281123524454 0.8539369611260395 0.0613116752031709 1 1 1 1 K03785 0.5057142857142857 0.1481481481481481 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 54.0 268.0 266.0 2.0 0.992592592592593 E 213.0 56.0 5.0 0.759259259259259 COG0169 Shikimate_5-dehydrogenase AroE 269.0 0.79182156133829 0.20817843866171 0.266999903875423 0.506983438503058 0.3869916711892405 0.239983534627635 0 0 0 0 K03786 0.0 0.6552706552706553 aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 107.0 239.0 235.0 4.0 0.971544715447154 E 0.0 246.0 3.0 0.975609756097561 COG0757 3-dehydroquinate_dehydratase AroQ 246.0 0.0 1.0 0.002014653425291 0.322595568641618 0.1623051110334545 0.320580915216327 0 0 0 0 K03787 0.4285714285714285 0.6438746438746439 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] path:map00230,path:map00240,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 91.0 369.0 320.0 4.0 0.838636363636364 S 183.0 257.0 1.0 1.0 COG0496 Broad_specificity_polyphosphatase_and_5'/3'-nucleotidase_SurE SurE 440.0 0.4159090909090909 0.5840909090909091 0.0619962354289803 0.0042904763032745 0.0331433558661274 0.0577057591257058 0 0 0 0 K03788 0.0 0.0199430199430199 aphA; acid phosphatase (class B) [EC:3.1.3.2] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 182.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3700 Acid_phosphatase,_class_B AphA 7.0 0.0 1.0 0.0044805583927723 0.009369317885951 0.0069249381393616 0.0048887594931787 0 0 0 0 K03789 0.0 0.0 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266] 578.0 505.0 7.0 0.828080229226361 K 0.0 0.0 5.0 0.51 COG0456 Ribosomal_protein_S18_acetylase_RimI_and_related_acetyltransferases RimI 0.0 0 0 0 0 K03790 0.08 0.3988603988603988 rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267] 10.0 252.0 244.0 5.0 0.958174904942966 J 31.0 231.0 6.0 0.954372623574144 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 262.0 0.1183206106870229 0.8816793893129771 0.290869981318609 0.165491321370567 0.228180651344588 0.125378659948042 0 0 0 0 K03791 0.0028571428571428 0.0883190883190883 K03791; putative chitinase 49.0 19.0 3.0 4.0 0.513513513513513 M 1.0 36.0 7.0 0.594594594594595 COG3179 Chitinase,_GH19_family GH19 37.0 0.027027027027027 0.972972972972973 0.0588646837202682 0.868843703582027 0.4638541936511476 0.8099790198617588 0 0 0 0 K03793 0.0171428571428571 0.1111111111111111 PTR1; pteridine reductase [EC:1.5.1.33] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 182.0 47.0 46.0 2.0 0.979166666666667 IQ 7.0 41.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 48.0 0.1458333333333333 0.8541666666666666 0.0015218187954602 0.0439870115737883 0.0227544151846242 0.0424651927783281 0 0 0 0 K03794 0.0028571428571428 0.0626780626780626 sirB; sirohydrochlorin ferrochelatase [EC:4.99.1.4] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 101.0 22.0 18.0 2.0 0.846153846153846 S 1.0 25.0 2.0 0.961538461538462 COG2138 Sirohydrochlorin_ferrochelatase SirB 26.0 0.0384615384615384 0.9615384615384616 0.0345913077196578 0.623088940026298 0.3288401238729779 0.5884976323066402 0 0 0 0 K03795 0.1628571428571428 0.1794871794871795 cbiX; sirohydrochlorin cobaltochelatase [EC:4.99.1.3] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 46.0 67.0 30.0 6.0 0.492647058823529 S 65.0 71.0 4.0 0.963235294117647 COG2138 Sirohydrochlorin_ferrochelatase SirB 136.0 0.4779411764705882 0.5220588235294118 0.0171946249000192 0.815377245829346 0.4162859353646826 0.7981826209293268 0 0 0 0 K03796 0.0028571428571428 0.0883190883190883 bax; Bax protein 155.0 38.0 0.0 1.0 1.0 S 1.0 37.0 1.0 1.0 COG2992 Uncharacterized_FlgJ-related_protein Bax 38.0 0.0263157894736842 0.9736842105263158 0.0077093851598599 0.116144223547336 0.0619268043535979 0.1084348383874761 0 0 0 0 K03797 0.0085714285714285 0.886039886039886 E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102] 43.0 552.0 531.0 6.0 0.951724137931034 M 4.0 576.0 6.0 0.946551724137931 COG0793 C-terminal_processing_protease_CtpA/Prc,_contains_a_PDZ_domain CtpA 580.0 0.0068965517241379 0.993103448275862 0.0008203882260844 0.0351824506207165 0.0180014194234004 0.0343620623946321 0 0 0 0 K03798 0.0085714285714285 0.9886039886039886 ftsH, hflB; cell division protease FtsH [EC:3.4.24.-] 343.0 506.0 485.0 2.0 0.960151802656546 O 3.0 524.0 3.0 0.994307400379507 COG0465 ATP-dependent_Zn_proteases HflB 527.0 0.0056925996204933 0.9943074003795066 0.949453325247238 0.947463471444968 0.948458398346103 0.00198985380227 0 0 1 1 K03799 0.7657142857142857 0.6182336182336182 htpX; heat shock protein HtpX [EC:3.4.24.-] 64.0 691.0 649.0 3.0 0.94141689373297 O 458.0 276.0 2.0 0.510899182561308 COG0281 Malic_enzyme SfcA 734.0 0.6239782016348774 0.3760217983651226 0.0213922880488211 0.345427423075419 0.18340985556212 0.3240351350265979 0 0 0 0 K03800 0.4371428571428571 0.3988603988603988 lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20] path:map00785,path:map01100,path:map01240 Lipoic acid metabolism,Metabolic pathways,Biosynthesis of cofactors 45.0 466.0 463.0 3.0 0.989384288747346 H 217.0 174.0 1.0 1.0 COG0095 Lipoate-protein_ligase_A LplA 391.0 0.5549872122762148 0.4450127877237851 0.778136935757869 0.898487712799781 0.8383123242788251 0.120350777041912 1 1 1 1 K03801 0.0857142857142857 0.5356125356125356 lipB; lipoyl(octanoyl) transferase [EC:2.3.1.181] path:map00785,path:map01100,path:map01240 Lipoic acid metabolism,Metabolic pathways,Biosynthesis of cofactors 89.0 228.0 223.0 4.0 0.966101694915254 H 38.0 198.0 3.0 0.974576271186441 COG0321 Lipoate-protein_ligase_B LipB 236.0 0.1610169491525423 0.8389830508474576 0.0066452607653191 0.0043353050376314 0.0054902829014752 0.0023099557276877 0 0 0 0 K03802 0.0171428571428571 0.1481481481481481 cphA; cyanophycin synthetase [EC:6.3.2.29 6.3.2.30] 243.0 22.0 0.0 6.0 0.289473684210526 HJ 7.0 69.0 3.0 0.802631578947369 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 76.0 0.0921052631578947 0.9078947368421052 0.0479413580669653 0.730469447073575 0.3892054025702701 0.6825280890066097 0 0 0 0 K03803 0.0 0.188034188034188 rseC; sigma-E factor negative regulatory protein RseC 66.0 72.0 0.0 1.0 1.0 T 0.0 72.0 1.0 1.0 COG3086 RseC,_positive_regulator_of_sigma_E_activity RseC 72.0 0.0 1.0 0.063566360472347 0.0035613053190436 0.0335638328956953 0.0600050551533034 0 0 0 0 K03804 0.0 0.0142450142450142 mukE; chromosome partition protein MukE 232.0 5.0 0.0 1.0 1.0 D 0.0 5.0 1.0 1.0 COG3095 Chromosome_condensin_MukBEF,_MukE_localization_factor MukE 5.0 0.0 1.0 3.5495916044287205e-21 3.3835867081697103e-17 1.691970833665077e-17 3.3832317490092666e-17 0 0 0 0 K03805 0.0028571428571428 0.0427350427350427 dsbG; thiol:disulfide interchange protein DsbG 92.0 16.0 15.0 2.0 0.941176470588235 O 1.0 16.0 1.0 1.0 COG1651 Protein_thiol-disulfide_isomerase_DsbC DsbG 17.0 0.0588235294117647 0.9411764705882352 0.0612632280919081 0.404582728217827 0.2329229781548675 0.3433195001259189 0 0 0 0 K03806 0.0 0.131054131054131 ampD; N-acetyl-anhydromuramoyl-L-alanine amidase [EC:3.5.1.28] 104.0 48.0 46.0 3.0 0.941176470588235 V 0.0 51.0 3.0 0.92156862745098 COG3023 N-acetyl-anhydromuramyl-L-alanine_amidase_AmpD AmpD 51.0 0.0 1.0 0.0058077262926824 0.0150473933736567 0.0104275598331695 0.0092396670809743 0 0 0 0 K03807 0.0 0.0313390313390313 ampE; AmpE protein 236.0 9.0 0.0 1.0 1.0 V 0.0 11.0 1.0 1.0 COG3725 Membrane_protein_AmpE_required_for_beta-lactamase_induction AmpE 11.0 0.0 1.0 0.0029533674199331 0.00693369296534 0.0049435301926365 0.0039803255454069 0 0 0 0 K03808 0.0 0.1054131054131054 pqiA; paraquat-inducible protein A 134.0 57.0 0.0 1.0 1.0 S 0.0 57.0 1.0 1.0 COG2995 Intermembrane_transporter_PqiABC_subunit_PqiA PqiA 57.0 0.0 1.0 0.0032164749229454 0.0105322390090175 0.0068743569659814 0.0073157640860721 0 0 0 0 K03809 0.1142857142857142 0.2934472934472934 wrbA; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 112.0 103.0 50.0 5.0 0.613095238095238 S 42.0 126.0 4.0 0.815476190476191 COG0655 Multimeric_flavodoxin_WrbA,_includes_NAD(P)H:quinone_oxidoreductase WrbA 168.0 0.25 0.75 0.208486855123506 0.195110280455027 0.2017985677892665 0.0133765746684789 0 0 0 0 K03810 0.0028571428571428 0.1139601139601139 mviM; virulence factor 199.0 39.0 35.0 2.0 0.906976744186046 S 1.0 42.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 43.0 0.0232558139534883 0.9767441860465116 0.0348071150515254 0.781100516120274 0.4079538155858997 0.7462934010687485 0 0 0 0 K03811 0.0057142857142857 0.1823361823361823 pnuC; nicotinamide mononucleotide transporter 141.0 74.0 73.0 2.0 0.986666666666667 H 2.0 73.0 2.0 0.986666666666667 COG3201 Nicotinamide_riboside_transporter_PnuC PnuC 75.0 0.0266666666666666 0.9733333333333334 0.0278925072094861 0.0198245729567778 0.0238585400831319 0.0080679342527082 0 0 0 0 K03812 0.0 0.0284900284900284 rmf; ribosome modulation factor 56.0 11.0 0.0 1.0 1.0 J 0.0 11.0 1.0 1.0 COG3130 Ribosome_modulation_factor Rmf 11.0 0.0 1.0 0.0243752789264574 0.0265714067780069 0.0254733428522321 0.0021961278515495 0 0 0 0 K03813 0.0314285714285714 0.0826210826210826 modD; molybdenum transport protein [EC:2.4.2.-] 229.0 42.0 0.0 1.0 1.0 H 11.0 31.0 1.0 1.0 COG0157 Nicotinate-nucleotide_pyrophosphorylase NadC 42.0 0.2619047619047619 0.7380952380952381 0.0313150368281271 0.110478220236029 0.070896628532078 0.0791631834079019 0 0 0 0 K03814 0.0 0.2364672364672364 mtgA; monofunctional glycosyltransferase [EC:2.4.1.129] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 157.0 90.0 0.0 1.0 1.0 M 0.0 90.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 90.0 0.0 1.0 0.0061998812995595 0.0082466593304187 0.007223270314989 0.0020467780308591 0 0 0 0 K03815 0.0028571428571428 0.0313390313390313 229.0 13.0 0.0 1.0 1.0 F 1.0 12.0 1.0 1.0 COG0005 Purine_nucleoside_phosphorylase XapA 13.0 0.0769230769230769 0.9230769230769232 0.0907654914717728 0.156381993241033 0.1235737423564029 0.0656165017692601 0 0 0 0 K03816 0.0028571428571428 0.150997150997151 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] path:map00230,path:map01100,path:map01110,path:map01232 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 175.0 54.0 0.0 1.0 1.0 F 1.0 53.0 1.0 1.0 COG0503 Adenine/guanine_phosphoribosyltransferase_or_related_PRPP-binding_protein Apt 54.0 0.0185185185185185 0.9814814814814816 0.0103062315831117 0.0886293478490314 0.0494677897160715 0.0783231162659197 0 0 0 0 K03817 0.0342857142857142 0.0769230769230769 rimL; ribosomal-protein-serine acetyltransferase [EC:2.3.1.-] 127.0 42.0 0.0 1.0 1.0 J 12.0 30.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 42.0 0.2857142857142857 0.7142857142857143 0.0605387958275946 0.107743024023144 0.0841409099253693 0.0472042281955493 0 0 0 0 K03818 0.0028571428571428 0.1082621082621082 wcaF; putative colanic acid biosynthesis acetyltransferase WcaF [EC:2.3.1.-] path:map00543 Exopolysaccharide biosynthesis 141.0 45.0 44.0 2.0 0.978260869565217 S 1.0 45.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 46.0 0.0217391304347826 0.9782608695652174 0.0297531856044507 0.0742951497085979 0.0520241676565242 0.0445419641041471 0 0 0 0 K03819 0.0 0.017094017094017 wcaB; putative colanic acid biosynthesis acetyltransferase WcaB [EC:2.3.1.-] path:map00543 Exopolysaccharide biosynthesis 156.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG1045 Serine_acetyltransferase CysE 6.0 0.0 1.0 0.111364557722459 0.273044508049184 0.1922045328858215 0.161679950326725 0 0 0 0 K03820 0.0028571428571428 0.6467236467236467 lnt; apolipoprotein N-acyltransferase [EC:2.3.1.269] 100.0 272.0 0.0 1.0 1.0 M 1.0 271.0 3.0 0.9375 COG0815 Apolipoprotein_N-acyltransferase Lnt 272.0 0.0036764705882352 0.9963235294117648 0.0036828521237504 0.0218033076888112 0.0127430799062808 0.0181204555650608 0 0 0 0 K03821 0.12 0.1737891737891738 phaC, phbC; poly[(R)-3-hydroxyalkanoate] polymerase subunit PhaC [EC:2.3.1.304] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 187.0 171.0 169.0 3.0 0.977142857142857 I 62.0 113.0 5.0 0.96 COG3243 Poly-beta-hydroxybutyrate_synthase PhaC 175.0 0.3542857142857142 0.6457142857142857 0.0010393268081686 0.0048307982080605 0.0029350625081145 0.0037914713998919 0 0 0 0 K03822 0.0 0.0056980056980056 K03822; putative long chain acyl-CoA synthase [EC:6.2.1.-] 979.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 2.0 0.0 1.0 0 0 0 0 K03823 0.1314285714285714 0.3874643874643874 pat, bar; phosphinothricin acetyltransferase [EC:2.3.1.183] path:map00440,path:map01110 Phosphonate and phosphinate metabolism,Biosynthesis of secondary metabolites 56.0 177.0 129.0 3.0 0.776315789473684 M 55.0 173.0 4.0 0.907894736842105 COG1247 L-amino_acid_N-acyltransferase_MnaT MnaT 228.0 0.2412280701754386 0.7587719298245614 0.138434194780584 0.202994767499668 0.170714481140126 0.064560572719084 0 0 0 0 K03824 0.02 0.1709401709401709 yhbS; putative acetyltransferase [EC:2.3.1.-] 70.0 63.0 56.0 4.0 0.851351351351351 S 7.0 67.0 2.0 0.986486486486486 COG3153 Predicted_N-acetyltransferase_YhbS yhbS 74.0 0.0945945945945946 0.9054054054054054 0.0186926379043659 0.146954311708225 0.0828234748062954 0.1282616738038591 0 0 0 0 K03825 0.0485714285714285 0.0769230769230769 aaaT; L-phenylalanine/L-methionine N-acetyltransferase [EC:2.3.1.53 2.3.1.-] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 74.0 22.0 2.0 3.0 0.431372549019608 K 21.0 30.0 3.0 0.411764705882353 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 51.0 0.4117647058823529 0.5882352941176471 0.0652796854231912 0.194947124925377 0.1301134051742841 0.1296674395021858 0 0 0 0 K03826 0.0142857142857142 0.0797720797720797 yiaC; putative acetyltransferase [EC:2.3.1.-] 58.0 34.0 32.0 2.0 0.944444444444444 K 5.0 31.0 2.0 0.944444444444444 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 36.0 0.1388888888888889 0.8611111111111112 0.0176005059644975 0.0618102251405491 0.0397053655525233 0.0442097191760516 0 0 0 0 K03827 0.0 0.1082621082621082 yjaB; putative acetyltransferase [EC:2.3.1.-] 52.0 41.0 38.0 3.0 0.911111111111111 K 0.0 45.0 3.0 0.911111111111111 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 45.0 0.0 1.0 0.0174438644937203 0.0361897755453789 0.0268168200195496 0.0187459110516586 0 0 0 0 K03828 0.0371428571428571 0.1139601139601139 yjgM; putative acetyltransferase [EC:2.3.1.-] 75.0 55.0 53.0 3.0 0.932203389830508 K 13.0 46.0 4.0 0.915254237288136 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 59.0 0.2203389830508474 0.7796610169491526 0.0265729428808995 0.0708223695843869 0.0486976562326432 0.0442494267034873 0 0 0 0 K03829 0.0085714285714285 0.1168091168091168 yedL; putative acetyltransferase [EC:2.3.1.-] 95.0 47.0 0.0 1.0 1.0 K 3.0 44.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 47.0 0.0638297872340425 0.9361702127659576 0.0220042313787475 0.0306191706077347 0.0263117009932411 0.0086149392289872 0 0 0 0 K03830 0.0514285714285714 0.1424501424501424 yafP; putative acetyltransferase [EC:2.3.1.-] 28.0 47.0 33.0 5.0 0.643835616438356 K 20.0 53.0 4.0 0.657534246575342 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 73.0 0.273972602739726 0.726027397260274 0.0389488007336926 0.319302698131356 0.1791257494325243 0.2803538973976633 0 0 0 0 K03831 0.0171428571428571 0.168091168091168 mogA; molybdopterin adenylyltransferase [EC:2.7.7.75] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 136.0 64.0 63.0 3.0 0.96969696969697 H 6.0 60.0 1.0 1.0 COG0521 Molybdopterin_biosynthesis_enzyme_MoaB/MogA MoaB 66.0 0.0909090909090909 0.9090909090909092 0.0045424266539123 0.0105667722329412 0.0075545994434267 0.0060243455790289 0 0 0 0 K03832 0.0 0.0 tonB; periplasmic protein TonB 440.0 396.0 9.0 0.878243512974052 M 0.0 0.0 6.0 0.988118811881188 COG0810 Periplasmic_protein_TonB,_links_inner_and_outer_membranes TonB 0.0 0 0 0 0 K03833 0.0542857142857142 0.301994301994302 selB, EEFSEC; selenocysteine-specific elongation factor 311.0 128.0 126.0 3.0 0.977099236641221 J 20.0 111.0 3.0 0.969465648854962 COG3276 Selenocysteine-specific_translation_elongation_factor_SelB SelB 131.0 0.1526717557251908 0.8473282442748091 0.77911320922322 0.996712549373275 0.8879128792982476 0.217599340150055 1 1 1 1 K03834 0.0057142857142857 0.0455840455840455 tyrP; tyrosine-specific transport protein 314.0 27.0 21.0 3.0 0.794117647058823 E 2.0 32.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 34.0 0.0588235294117647 0.9411764705882352 0.0042838270875501 0.0106450356969825 0.0074644313922663 0.0063612086094324 0 0 0 0 K03835 0.0 0.017094017094017 mtr; tryptophan-specific transport protein 408.0 6.0 5.0 3.0 0.75 E 0.0 8.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 8.0 0.0 1.0 0.0169101732103973 0.0457387969726895 0.0313244850915434 0.0288286237622921 0 0 0 0 K03836 0.0 0.0056980056980056 tnaB; low affinity tryptophan permease 410.0 2.0 1.0 2.0 0.666666666666667 E 0.0 3.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 3.0 0.0 1.0 0 0 0 0 K03837 0.0 0.0256410256410256 sdaC; serine transporter 417.0 10.0 0.0 1.0 1.0 E 0.0 10.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 10.0 0.0 1.0 0.0280129638051012 0.0744153433561647 0.0512141535806329 0.0464023795510635 0 0 0 0 K03838 0.0 0.0056980056980056 tdcC; threonine transporter 441.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0814 Amino_acid_permease SdaC 2.0 0.0 1.0 0 0 0 0 K03839 0.0342857142857142 0.1652421652421652 fldA, nifF, isiB; flavodoxin I 77.0 83.0 0.0 1.0 1.0 C 13.0 70.0 1.0 1.0 COG0716 Flavodoxin FldA 83.0 0.1566265060240964 0.8433734939759037 0.066902604136173 0.694183645310143 0.380543124723158 0.62728104117397 0 0 0 0 K03840 0.0 0.0284900284900284 fldB; flavodoxin II 172.0 10.0 0.0 1.0 1.0 C 0.0 10.0 1.0 1.0 COG0716 Flavodoxin FldA 10.0 0.0 1.0 0.0096134343396818 0.0165360875448602 0.013074760942271 0.0069226532051783 0 0 0 0 K03841 0.1857142857142857 0.3162393162393162 FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map04152,path:map04910,path:map04922 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,AMPK signaling pathway,Insulin signaling pathway,Glucagon signaling pathway 198.0 192.0 189.0 2.0 0.984615384615385 G 74.0 121.0 1.0 1.0 COG0158 Fructose-1,6-bisphosphatase Fbp 195.0 0.3794871794871794 0.6205128205128205 0.0070802462129325 0.13289311484134 0.0699866805271362 0.1258128686284075 0 0 0 0 K03843 0.0028571428571428 0.0028490028490028 ALG2; alpha-1,3/alpha-1,6-mannosyltransferase [EC:2.4.1.132 2.4.1.257] path:map00510,path:map00513,path:map01100 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways 379.0 2.0 0.0 1.0 1.0 M 1.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 2.0 0.5 0.5 0 0 0 0 K03851 0.0 0.0626780626780626 tpa; taurine-pyruvate aminotransferase [EC:2.6.1.77] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 393.0 17.0 10.0 2.0 0.708333333333333 H 0.0 24.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 24.0 0.0 1.0 0.0360191284725875 0.525105749771605 0.2805624391220962 0.4890866212990175 0 0 0 0 K03852 0.0 0.0541310541310541 xsc; sulfoacetaldehyde acetyltransferase [EC:2.3.3.15] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 532.0 15.0 7.0 2.0 0.652173913043478 EH 0.0 23.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 23.0 0.0 1.0 0.0325258988702446 0.0947782174870574 0.063652058178651 0.0622523186168128 0 0 0 0 K03855 0.1257142857142857 0.0797720797720797 fixX; ferredoxin like protein 53.0 87.0 0.0 1.0 1.0 C 56.0 31.0 1.0 1.0 COG2440 Ferredoxin-like_protein_FixX FixX 87.0 0.6436781609195402 0.3563218390804598 0.399654980120647 0.860668530544457 0.630161755332552 0.46101355042381 0 0 0 0 K03856 0.1228571428571428 0.4387464387464387 AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 228.0 263.0 243.0 2.0 0.929328621908127 E 50.0 233.0 3.0 0.932862190812721 COG2876 3-deoxy-D-arabino-heptulosonate_7-phosphate_(DAHP)_synthase AroGA 283.0 0.1766784452296819 0.823321554770318 0.676546733163532 0.83664623836383 0.756596485763681 0.160099505200298 0 1 0 1 K03862 0.0 0.0085470085470085 vanA; vanillate monooxygenase [EC:1.14.13.82] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 283.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 3.0 0.0 1.0 0 0 0 0 K03863 0.0 0.0227920227920227 vanB; vanillate monooxygenase ferredoxin subunit path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 297.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 12.0 0.0 1.0 0.0063322322522769 0.010036969869091 0.0081846010606839 0.0037047376168141 0 0 0 0 K03867 0.0 0.0398860398860398 BGLUT; UDP-glucose:tetrahydrobiopterin glucosyltransferase [EC:2.4.1.-] 338.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 15.0 0.0 1.0 0.011786010965094 0.0188799457679484 0.0153329783665212 0.0070939348028544 0 0 0 0 K03885 0.2857142857142857 0.5270655270655271 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 115.0 395.0 349.0 6.0 0.875831485587583 C 162.0 287.0 7.0 0.853658536585366 COG1252 NADH_dehydrogenase,_FAD-containing_subunit Ndh 449.0 0.3608017817371937 0.6391982182628062 0.0003837221772615 0.655793517411527 0.3280886197943942 0.6554097952342656 0 0 0 0 K03886 0.0028571428571428 0.1367521367521367 MQCRA, qcrA, bfcA, petC; menaquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.-] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 77.0 64.0 61.0 4.0 0.927536231884058 C 1.0 68.0 2.0 0.927536231884058 COG0723 Rieske_Fe-S_protein QcrA/PetC 69.0 0.0144927536231884 0.9855072463768116 0.0339450657077894 0.590660287139855 0.3123026764238222 0.5567152214320655 0 0 0 0 K03887 0.0057142857142857 0.0484330484330484 MQCRB, qcrB, bfcB, petB; menaquinol-cytochrome c reductase cytochrome b subunit path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 206.0 19.0 0.0 1.0 1.0 C 2.0 17.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 19.0 0.1052631578947368 0.8947368421052632 0.00794979747959 0.0061750107786322 0.0070624041291111 0.0017747867009577 0 0 0 0 K03888 0.0028571428571428 0.0541310541310541 MQCRC, qcrC, bfcC, petD; menaquinol-cytochrome c reductase cytochrome b/c subunit path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 80.0 20.0 0.0 1.0 1.0 C 1.0 19.0 2.0 0.75 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 20.0 0.05 0.95 0.0738081534875622 0.114124902384926 0.0939665279362441 0.0403167488973637 0 0 0 0 K03889 0.0 0.0968660968660968 qcrC; ubiquinol-cytochrome c reductase cytochrome c subunit path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 187.0 36.0 35.0 2.0 0.972972972972973 C 0.0 37.0 2.0 0.837837837837838 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 37.0 0.0 1.0 0.0046351715141773 0.0122298405091757 0.0084325060116765 0.0075946689949984 0 0 0 0 K03890 0.0 0.0769230769230769 qcrA; ubiquinol-cytochrome c reductase iron-sulfur subunit path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 286.0 27.0 0.0 1.0 1.0 C 0.0 27.0 1.0 1.0 COG0723 Rieske_Fe-S_protein QcrA/PetC 27.0 0.0 1.0 0.0023011750450057 0.0037872342250766 0.0030442046350411 0.0014860591800709 0 0 0 0 K03891 0.0 0.0769230769230769 qcrB; ubiquinol-cytochrome c reductase cytochrome b subunit path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 463.0 29.0 0.0 1.0 1.0 C 0.0 29.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 29.0 0.0 1.0 0.0019319629389678 0.0022433944676191 0.0020876787032934 0.0003114315286512 0 0 0 0 K03892 0.2628571428571428 0.6524216524216524 arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor 15.0 514.0 501.0 5.0 0.966165413533835 K 116.0 415.0 5.0 0.947368421052632 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 531.0 0.2184557438794727 0.7815442561205274 0.274959800982765 0.511354926121242 0.3931573635520035 0.236395125138477 0 0 0 0 K03893 0.0914285714285714 0.1709401709401709 arsB; arsenical pump membrane protein 300.0 108.0 103.0 2.0 0.955752212389381 P 39.0 74.0 1.0 1.0 COG1055 Na+/H+_antiporter_NhaD_or_related_arsenite_permease ArsB 113.0 0.3451327433628318 0.6548672566371682 0.80328767918208 0.988738142638773 0.8960129109104265 0.185450463456693 1 1 1 1 K03894 0.0 0.0085470085470085 iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38] path:map00997,path:map01100,path:map01110,path:map01120 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 549.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG4264 Siderophore_synthetase_component_IucA/IucC/SbnC IucA 3.0 0.0 1.0 0 0 0 0 K03895 0.0 0.0199430199430199 iucC; aerobactin synthase [EC:6.3.2.39] path:map00997,path:map01100,path:map01110,path:map01120 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 549.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 1.0 1.0 COG4264 Siderophore_synthetase_component_IucA/IucC/SbnC IucA 7.0 0.0 1.0 0.003785215396015 0.0150738418458773 0.0094295286209461 0.0112886264498623 0 0 0 0 K03896 0.0 0.0199430199430199 iucB; acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102] path:map00997,path:map01100,path:map01110,path:map01120 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 282.0 7.0 0.0 1.0 1.0 J 0.0 7.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 7.0 0.0 1.0 0.175198321360579 0.220959670146581 0.19807899575358 0.0457613487860019 0 0 0 0 K03897 0.0257142857142857 0.0911680911680911 iucD; lysine N6-hydroxylase [EC:1.14.13.59] path:map00997,path:map01100,path:map01110,path:map01120 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 353.0 38.0 34.0 2.0 0.904761904761905 Q 9.0 33.0 1.0 1.0 COG3486 Lysine/ornithine_N-monooxygenase IucD 42.0 0.2142857142857142 0.7857142857142857 0.0065753102103395 0.0086882648742828 0.0076317875423111 0.0021129546639433 0 0 0 0 K03910 0.0028571428571428 0.0 A2M; alpha-2-macroglobulin path:map04610 Complement and coagulation cascades 1377.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG2373 Uncharacterized_conserved_protein_YfaS,_alpha-2-macroglobulin_family YfaS 1.0 1.0 0.0 0 0 0 0 K03911 0.0 0.0028490028490028 SERPINC1, AT3; antithrombin III path:map04610 Complement and coagulation cascades 859.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG4826 Serine_protease_inhibitor SERPIN 1.0 0.0 1.0 0 0 0 0 K03918 0.0485714285714285 0.0712250712250712 lat; L-lysine 6-transaminase [EC:2.6.1.36] 367.0 39.0 37.0 3.0 0.928571428571429 E 17.0 25.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 42.0 0.4047619047619047 0.5952380952380952 0.0112766070153854 0.0323964621408933 0.0218365345781393 0.0211198551255078 0 0 0 0 K03919 0.0 0.0854700854700854 alkB; DNA oxidative demethylase [EC:1.14.11.33] 193.0 31.0 0.0 1.0 1.0 L 0.0 31.0 1.0 1.0 COG3145 Alkylated_DNA_repair_dioxygenase_AlkB AlkB 31.0 0.0 1.0 0.0294760412835191 0.0608145522866691 0.0451452967850941 0.03133851100315 0 0 0 0 K03921 0.0028571428571428 0.0854700854700854 FAB2, SSI2, desA1; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] path:map00061,path:map01040,path:map01100,path:map01212 Fatty acid biosynthesis,Biosynthesis of unsaturated fatty acids,Metabolic pathways,Fatty acid metabolism 206.0 23.0 14.0 3.0 0.676470588235294 F 1.0 33.0 3.0 0.705882352941177 COG0208 Ribonucleotide_reductase_beta_subunit,_ferritin-like_domain NrdB 34.0 0.0294117647058823 0.9705882352941176 0.100624707819331 0.762262501784775 0.4314436048020529 0.661637793965444 0 0 0 0 K03922 0.0 0.0028490028490028 desA2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2] path:map00061,path:map01040,path:map01100,path:map01212 Fatty acid biosynthesis,Biosynthesis of unsaturated fatty acids,Metabolic pathways,Fatty acid metabolism 275.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 COG0208 Ribonucleotide_reductase_beta_subunit,_ferritin-like_domain NrdB 1.0 0.0 1.0 0 0 0 0 K03923 0.0028571428571428 0.0541310541310541 mdaB; NADPH dehydrogenase (quinone) [EC:1.6.5.10] 159.0 20.0 19.0 2.0 0.952380952380952 S 1.0 20.0 1.0 1.0 COG2249 Putative_NADPH-quinone_reductase_(modulator_of_drug_activity_B) MdaB 21.0 0.0476190476190476 0.9523809523809524 0.0233708890828354 0.056481811134056 0.0399263501084457 0.0331109220512206 0 0 0 0 K03924 0.6771428571428572 0.7065527065527065 moxR; MoxR-like ATPase [EC:3.6.3.-] 102.0 943.0 904.0 7.0 0.897240723120837 S 504.0 546.0 3.0 0.996194100856327 COG0714 MoxR-like_ATPase MoxR 1050.0 0.48 0.52 0.0378093895005044 0.115072691809495 0.0764410406549997 0.0772633023089906 0 0 0 0 K03925 0.0 0.7749287749287749 mraZ; transcriptional regulator MraZ 51.0 279.0 0.0 1.0 1.0 K 0.0 279.0 1.0 1.0 COG2001 MraZ,_DNA-binding_transcriptional_regulator_and_inhibitor_of_RsmH_methyltransferase_activity MraZ 279.0 0.0 1.0 0.0199312745292483 0.132998284261988 0.0764647793956181 0.1130670097327397 0 0 0 0 K03926 0.5485714285714286 0.3675213675213675 cutA; periplasmic divalent cation tolerance protein 53.0 332.0 0.0 1.0 1.0 P 197.0 135.0 1.0 1.0 COG1324 Divalent_cation_tolerance_protein_CutA CutA1 332.0 0.5933734939759037 0.4066265060240964 0.302990652960723 0.851255184095017 0.57712291852787 0.548264531134294 0 0 0 0 K03928 0.0742857142857142 0.2564102564102564 yvaK; carboxylesterase [EC:3.1.1.1] 67.0 124.0 108.0 3.0 0.810457516339869 S 35.0 118.0 6.0 0.901960784313726 COG1647 Esterase/lipase YvaK 153.0 0.2287581699346405 0.7712418300653595 0.314181284302686 0.972478874268709 0.6433300792856975 0.6582975899660231 0 0 0 0 K03929 0.0171428571428571 0.168091168091168 pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] 166.0 108.0 105.0 4.0 0.939130434782609 I 7.0 108.0 7.0 0.91304347826087 COG2272 Carboxylesterase_type_B PnbA 115.0 0.0608695652173913 0.9391304347826088 0.0037811776877742 0.0085533271024503 0.0061672523951122 0.004772149414676 0 0 0 0 K03930 0.0 0.0199430199430199 estA; putative tributyrin esterase [EC:3.1.1.-] 246.0 5.0 3.0 2.0 0.714285714285714 S 0.0 7.0 1.0 1.0 COG0627 S-formylglutathione_hydrolase_FrmB FrmB 7.0 0.0 1.0 0.0594340449234004 0.13573093640613 0.0975824906647652 0.0762968914827295 0 0 0 0 K03931 0.0142857142857142 0.0398860398860398 ygjK; glucosidase [EC:3.2.1.-] 243.0 22.0 0.0 1.0 1.0 G 6.0 15.0 3.0 0.636363636363636 COG3408 Glycogen_debranching_enzyme_(alpha-1,6-glucosidase) GDB1 21.0 0.2857142857142857 0.7142857142857143 0.267273086367395 0.441151646602405 0.3542123664849 0.17387856023501 0 0 0 0 K03932 0.0485714285714285 0.1225071225071225 lpqC; polyhydroxybutyrate depolymerase 84.0 77.0 76.0 4.0 0.9625 Q 22.0 58.0 5.0 0.95 COG3509 Acetyl_xylan_esterase_AxeA_and_related_esterases,_LpqC_family LpqC 80.0 0.275 0.725 0.0085862931216605 0.0407733658154002 0.0246798294685303 0.0321870726937397 0 0 0 0 K03933 0.0085714285714285 0.0797720797720797 cpbD; chitin-binding protein 42.0 60.0 52.0 4.0 0.821917808219178 S 4.0 69.0 8.0 0.575342465753425 COG3397 Predicted_carbohydrate-binding_protein,_contains_CBM5_and_CBM33_domains 73.0 0.0547945205479452 0.9452054794520548 0.0022523253811251 0.0040528961102313 0.0031526107456782 0.0018005707291062 0 0 0 0 K03940 0.0057142857142857 0.0113960113960113 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2] path:map00190,path:map01100,path:map04714,path:map04723,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Retrograde endocannabinoid signaling,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 120.0 7.0 0.0 1.0 1.0 C 3.0 4.0 1.0 1.0 COG0377 NADH:ubiquinone_oxidoreductase_20_kD_subunit_(chain_B)_or_related_Fe-S_oxidoreductase NuoB 7.0 0.4285714285714285 0.5714285714285714 0.0315773885017395 0.0657639439497083 0.0486706662257239 0.0341865554479688 0 0 0 0 K03941 0.0 0.0826210826210826 NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2] path:map00190,path:map01100,path:map04714,path:map04723,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Retrograde endocannabinoid signaling,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 159.0 29.0 0.0 1.0 1.0 C 0.0 29.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 29.0 0.0 1.0 0.0073668771976856 0.0117522046938883 0.0095595409457869 0.0043853274962027 0 0 0 0 K03943 0.0 0.1168091168091168 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2] path:map00190,path:map01100,path:map04714,path:map04723,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Retrograde endocannabinoid signaling,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 157.0 41.0 0.0 1.0 1.0 C 0.0 41.0 1.0 1.0 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 41.0 0.0 1.0 0.0080266373749863 0.0125281361446861 0.0102773867598362 0.0045014987696998 0 0 0 0 K03954 0.0028571428571428 0.0 NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 path:map00190,path:map01100,path:map04714,path:map04723,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208,path:map05415 Oxidative phosphorylation,Metabolic pathways,Thermogenesis,Retrograde endocannabinoid signaling,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 223.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG1428 Deoxyadenosine/deoxycytidine_kinase Dck 1.0 1.0 0.0 0 0 0 0 K03969 0.1857142857142857 0.3162393162393162 pspA; phage shock protein A 104.0 166.0 107.0 3.0 0.728070175438597 KT 67.0 161.0 2.0 0.986842105263158 COG1842 Phage_shock_protein_A PspA 228.0 0.293859649122807 0.706140350877193 0.0196413824528474 0.717329109793343 0.3684852461230952 0.6976877273404956 0 0 0 0 K03970 0.0 0.0541310541310541 pspB; phage shock protein B 44.0 13.0 7.0 2.0 0.68421052631579 S 0.0 21.0 5.0 0.476190476190476 2CJWQ 21.0 0.0 1.0 0.815676718697649 0.0455589142374258 0.4306178164675374 0.7701178044602233 0 0 1 1 K03971 0.0 0.0085470085470085 pspD; phage shock protein D 57.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2C1SN 3.0 0.0 1.0 0 0 0 0 K03972 0.0057142857142857 0.0655270655270655 pspE; phage shock protein E 77.0 23.0 21.0 2.0 0.92 P 2.0 23.0 1.0 1.0 COG0607 Rhodanese-related_sulfurtransferase PspE 25.0 0.08 0.92 0.216973841942803 0.549460658422081 0.383217250182442 0.332486816479278 0 0 0 0 K03973 0.1371428571428571 0.2792022792022792 pspC; phage shock protein C 41.0 154.0 138.0 2.0 0.905882352941176 KT 48.0 122.0 1.0 1.0 COG1983 Phage_shock_protein_PspC_(stress-responsive_transcriptional_regulator) PspC 170.0 0.2823529411764706 0.7176470588235294 0.391880718633101 0.262127029729698 0.3270038741813995 0.129753688903403 0 0 0 0 K03974 0.0 0.0598290598290598 pspF; psp operon transcriptional activator 298.0 17.0 13.0 2.0 0.80952380952381 K 0.0 21.0 3.0 0.619047619047619 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 21.0 0.0 1.0 0.0152333024612798 0.0437419349322748 0.0294876186967773 0.028508632470995 0 0 0 0 K03975 0.1171428571428571 0.2877492877492877 dedA; membrane-associated protein 91.0 151.0 139.0 3.0 0.888235294117647 S 44.0 128.0 4.0 0.976744186046512 COG0586 Membrane_integrity_protein_DedA,_putative_transporter,_DedA/Tvp38_family DedA 172.0 0.2558139534883721 0.7441860465116279 0.173607834438152 0.936290390800879 0.5549491126195155 0.762682556362727 0 0 0 0 K03976 0.0371428571428571 0.3447293447293447 ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] 115.0 111.0 88.0 3.0 0.804347826086956 S 14.0 124.0 1.0 1.0 COG2606 Cys-tRNA(Pro)_deacylase,_prolyl-tRNA_editing_enzyme_YbaK/EbsC EbsC 138.0 0.1014492753623188 0.8985507246376812 0.004422289484395 0.0170921483949445 0.0107572189396697 0.0126698589105495 0 0 0 0 K03977 0.0028571428571428 0.8917378917378918 engA, der; GTPase 275.0 316.0 296.0 4.0 0.905444126074498 S 1.0 348.0 4.0 0.92836676217765 COG1160 Double_Era-like_domain_GTPase_Der Der 349.0 0.0028653295128939 0.997134670487106 0.662835068380478 0.332644895858507 0.4977399821194925 0.330190172521971 0 0 0 1 K03978 0.0 0.5726495726495726 engB; GTP-binding protein 130.0 201.0 0.0 1.0 1.0 D 0.0 201.0 1.0 1.0 COG0218 GTP-binding_protein_EngB_required_for_normal_cell_division EngB 201.0 0.0 1.0 0.0123674575396475 0.0211278900129767 0.0167476737763121 0.0087604324733291 0 0 0 0 K03979 0.0028571428571428 0.9544159544159544 obgE, cgtA, MTG2; GTPase [EC:3.6.5.-] 247.0 328.0 314.0 2.0 0.95906432748538 S 1.0 341.0 1.0 1.0 COG0536 GTPase_involved_in_cell_partioning_and_DNA_repair Obg 342.0 0.0029239766081871 0.9970760233918128 0.126070938816994 0.013917892670468 0.069994415743731 0.1121530461465259 0 0 0 0 K03980 0.0028571428571428 0.7606837606837606 murJ, mviN; putative peptidoglycan lipid II flippase 111.0 265.0 228.0 11.0 0.74438202247191 S 1.0 355.0 4.0 0.963483146067416 COG0728 Lipid_II_flippase_MurJ/MviN_(peptidoglycan_biosynthesis) MurJ 356.0 0.0028089887640449 0.9971910112359552 0.391780703379366 0.95947371203949 0.675627207709428 0.567693008660124 0 0 0 0 K03981 0.0028571428571428 0.150997150997151 dsbC; thiol:disulfide interchange protein DsbC [EC:5.3.4.1] 60.0 65.0 54.0 3.0 0.844155844155844 O 1.0 76.0 2.0 0.948051948051948 COG1651 Protein_thiol-disulfide_isomerase_DsbC DsbG 77.0 0.0129870129870129 0.987012987012987 0.010488036833191 0.0158576024874759 0.0131728196603334 0.0053695656542848 0 0 0 0 K04013 0.0 0.0227920227920227 nrfB; cytochrome c-type protein NrfB 168.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG3303 Formate-dependent_nitrite_reductase,_periplasmic_cytochrome_c552_subunit NrfA 8.0 0.0 1.0 0.0428706709527093 0.0690961992048396 0.0559834350787744 0.0262255282521303 0 0 0 0 K04014 0.0 0.0398860398860398 nrfC; protein NrfC 161.0 18.0 0.0 1.0 1.0 C 0.0 18.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 18.0 0.0 1.0 0.0204927919898923 0.0352016920378439 0.0278472420138681 0.0147089000479516 0 0 0 0 K04015 0.02 0.0113960113960113 nrfD; protein NrfD 265.0 18.0 0.0 1.0 1.0 P 13.0 5.0 1.0 1.0 COG3301 Nitrite/polysulfide_reductase,_membrane_component_NrfD/PsrC NrfD 18.0 0.7222222222222222 0.2777777777777778 0.0074754701055842 0.0155142536629372 0.0114948618842607 0.008038783557353 0 0 0 0 K04016 0.0028571428571428 0.0427350427350427 nrfE; cytochrome c-type biogenesis protein NrfE 174.0 16.0 0.0 1.0 1.0 O 1.0 15.0 2.0 0.6875 COG3088 Cytochrome_c-type_biogenesis_protein_CcmH/NrfF NrfF 16.0 0.0625 0.9375 0.127629890557488 0.798293919018267 0.4629619047878774 0.670664028460779 0 0 0 0 K04017 0.0 0.0455840455840455 nrfF; formate-dependent nitrite reductase complex subunit NrfF 88.0 13.0 10.0 2.0 0.8125 O 0.0 16.0 1.0 1.0 COG3088 Cytochrome_c-type_biogenesis_protein_CcmH/NrfF NrfF 16.0 0.0 1.0 0.56856850920948 0.343403654257515 0.4559860817334975 0.2251648549519649 0 0 0 1 K04018 0.0 0.0683760683760683 nrfG; formate-dependent nitrite reductase complex subunit NrfG 42.0 27.0 0.0 1.0 1.0 O 0.0 26.0 3.0 0.518518518518519 COG4235 Cytochrome_c-type_biogenesis_protein_CcmH/NrfG NrfG 26.0 0.0 1.0 0.132362449846491 0.440296872580476 0.2863296612134835 0.3079344227339849 0 0 0 0 K04019 0.0085714285714285 0.0427350427350427 eutA; ethanolamine utilization protein EutA path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 407.0 21.0 0.0 1.0 1.0 E 3.0 18.0 3.0 0.80952380952381 COG4819 Ethanolamine_utilization_protein_EutA,_possible_chaperonin EutA 21.0 0.1428571428571428 0.8571428571428571 0.045663300895663 0.519822304492896 0.2827428026942795 0.474159003597233 0 0 0 0 K04020 0.0 0.017094017094017 eutD; phosphotransacetylase path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 323.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG0280 Phosphotransacetylase_(includes_Pta,_EutD_and_phosphobutyryltransferase) Pta 6.0 0.0 1.0 0.119306630698278 0.20066585079963 0.159986240748954 0.081359220101352 0 0 0 0 K04021 0.0 0.0313390313390313 eutE; aldehyde dehydrogenase path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 458.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 11.0 0.0 1.0 0.0297262633992997 0.144772923864894 0.0872495936320968 0.1150466604655942 0 0 0 0 K04022 0.0 0.0085470085470085 eutG; alcohol dehydrogenase path:map00010,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 146.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 3.0 0.0 1.0 0 0 0 0 K04023 0.0028571428571428 0.0455840455840455 eutH; ethanolamine transporter 345.0 17.0 0.0 1.0 1.0 E 1.0 16.0 1.0 1.0 COG3192 Ethanolamine_transporter_EutH,_required_for_ethanolamine_utilization_at_low_pH EutH 17.0 0.0588235294117647 0.9411764705882352 0.0231538123428502 0.647952730393987 0.3355532713684186 0.6247989180511369 0 0 0 0 K04024 0.0 0.0512820512820512 eutJ; ethanolamine utilization protein EutJ 251.0 19.0 0.0 1.0 1.0 E 0.0 19.0 1.0 1.0 COG4820 Ethanolamine_utilization_protein_EutJ,_possible_chaperonin EutJ 19.0 0.0 1.0 0.0265194768113457 0.111236858878059 0.0688781678447023 0.0847173820667133 0 0 0 0 K04025 0.0 0.0113960113960113 eutK; ethanolamine utilization protein EutK 83.0 4.0 0.0 1.0 1.0 CQ 0.0 4.0 1.0 1.0 COG4577 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmL/EutN CcmK 4.0 0.0 1.0 0.0441864707524067 0.0778102986719953 0.060998384712201 0.0336238279195886 0 0 0 0 K04026 0.0 0.0313390313390313 eutL; ethanolamine utilization protein EutL 217.0 11.0 0.0 1.0 1.0 E 0.0 11.0 1.0 1.0 COG4816 Ethanolamine_utilization_protein_EutL,_microcompartment_shell_protein EutL 11.0 0.0 1.0 0.0349486665165952 0.215658740074155 0.1253037032953751 0.1807100735575598 0 0 0 0 K04027 0.0028571428571428 0.094017094017094 eutM; ethanolamine utilization protein EutM 87.0 49.0 0.0 1.0 1.0 CQ 1.0 48.0 1.0 1.0 COG4577 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmL/EutN CcmK 49.0 0.0204081632653061 0.979591836734694 0.0045763197805841 0.0140024187733174 0.0092893692769507 0.0094260989927333 0 0 0 0 K04028 0.0028571428571428 0.1139601139601139 eutN; ethanolamine utilization protein EutN 67.0 66.0 65.0 2.0 0.985074626865672 CQ 2.0 65.0 3.0 0.955223880597015 COG4576 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmK/EutM CcmL 67.0 0.0298507462686567 0.9701492537313432 0.0368660562199162 0.334364604001621 0.1856153301107685 0.2974985477817048 0 0 0 0 K04029 0.0 0.0398860398860398 eutP; ethanolamine utilization protein EutP 132.0 14.0 0.0 1.0 1.0 E 0.0 14.0 1.0 1.0 COG4917 Ethanolamine_utilization_protein_EutP,_contains_a_P-loop_NTPase_domain EutP 14.0 0.0 1.0 0.0321761572713344 0.598031212784726 0.3151036850280302 0.5658550555133917 0 0 0 0 K04030 0.0 0.0398860398860398 eutQ; ethanolamine utilization protein EutQ 111.0 14.0 0.0 1.0 1.0 E 0.0 14.0 2.0 0.928571428571429 COG4766 Ethanolamine_utilization_protein_EutQ,_cupin_superfamily_(function_unknown) EutQ 14.0 0.0 1.0 0.0589691555969184 0.513412379539606 0.2861907675682621 0.4544432239426875 0 0 0 0 K04031 0.0 0.0398860398860398 eutS; ethanolamine utilization protein EutS 109.0 15.0 0.0 1.0 1.0 E 0.0 15.0 1.0 1.0 COG4810 Ethanolamine_utilization_protein_EutS,_microcompartment_shell_protein EutS 15.0 0.0 1.0 0.0349432755083625 0.609837528103466 0.3223904018059143 0.5748942525951035 0 0 0 0 K04032 0.0 0.0227920227920227 eutT; ethanolamine utilization cobalamin adenosyltransferase [EC:2.5.1.154] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 231.0 7.0 6.0 2.0 0.875 E 0.0 8.0 1.0 1.0 COG4812 Ethanolamine_utilization_protein_EutT,_cobalamin_adenosyltransferase EutT 8.0 0.0 1.0 0.0248125490413594 0.181328022374931 0.1030702857081452 0.1565154733335716 0 0 0 0 K04033 0.0 0.0341880341880341 eutR; AraC family transcriptional regulator, ethanolamine operon transcriptional activator 223.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 14.0 0.0 1.0 0.010236200341273 0.0187659746874739 0.0145010875143734 0.0085297743462008 0 0 0 0 K04034 0.2142857142857142 0.1965811965811965 bchE; anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase [EC:1.21.98.3] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 109.0 182.0 0.0 1.0 1.0 C 94.0 85.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 179.0 0.5251396648044693 0.4748603351955307 0.680686092301262 0.100429875856905 0.3905579840790835 0.580256216444357 0 1 0 1 K04035 0.0028571428571428 0.0797720797720797 E1.14.13.81, acsF, chlE; magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase [EC:1.14.13.81] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 323.0 26.0 18.0 4.0 0.68421052631579 H 1.0 37.0 3.0 0.868421052631579 COG1633 Rubrerythrin,_includes_spore_coat_protein_YhjR YhjR 38.0 0.0263157894736842 0.9736842105263158 0.0345966839825836 0.0864059944365847 0.0605013392095841 0.0518093104540011 0 0 0 0 K04036 0.0 0.037037037037037 bchJ; divinyl protochlorophyllide a 8-vinyl-reductase [EC:1.-.-.-] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 182.0 10.0 8.0 3.0 0.769230769230769 S 0.0 13.0 1.0 1.0 COG1719 Predicted_hydrocarbon_binding_protein,_contains_4VR_domain 13.0 0.0 1.0 0.0467967939687539 0.0945488699948397 0.0706728319817968 0.0477520760260858 0 0 0 0 K04037 0.0028571428571428 0.0797720797720797 chlL; light-independent protochlorophyllide reductase subunit L [EC:1.3.7.7] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 258.0 16.0 9.0 4.0 0.533333333333333 P 1.0 29.0 1.0 1.0 COG1348 Nitrogenase_ATPase_subunit_NifH/coenzyme_F430_biosynthesis_subunit_CfbC NifH/CfbC 30.0 0.0333333333333333 0.9666666666666668 0.0932828989407791 0.0142195170445844 0.0537512079926817 0.0790633818961946 0 0 0 0 K04038 0.0028571428571428 0.0797720797720797 chlN; light-independent protochlorophyllide reductase subunit N [EC:1.3.7.7] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 392.0 18.0 5.0 3.0 0.5625 C 1.0 31.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 32.0 0.03125 0.96875 0.0900427840523067 0.0192813838569954 0.054662083954651 0.0707614001953113 0 0 0 0 K04039 0.0028571428571428 0.0797720797720797 chlB; light-independent protochlorophyllide reductase subunit B [EC:1.3.7.7] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 465.0 16.0 0.0 3.0 0.484848484848485 F 2.0 31.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 33.0 0.0606060606060606 0.9393939393939394 0.010105047325777 0.0150774723832208 0.0125912598544989 0.0049724250574438 0 0 0 0 K04040 0.0142857142857142 0.1225071225071225 chlG, bchG; chlorophyll/bacteriochlorophyll a synthase [EC:2.5.1.62 2.5.1.133] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 229.0 53.0 0.0 1.0 1.0 H 5.0 48.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 53.0 0.0943396226415094 0.9056603773584906 0.0058584678520935 0.0566143827250902 0.0312364252885918 0.0507559148729967 0 0 0 0 K04041 0.0 0.0769230769230769 fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 585.0 28.0 0.0 1.0 1.0 G 0.0 28.0 1.0 1.0 COG3855 Fructose-1,6-bisphosphatase Fbp2 28.0 0.0 1.0 0.0153088447716129 0.0249005947482592 0.020104719759936 0.0095917499766462 0 0 0 0 K04042 0.62 0.8034188034188035 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 166.0 528.0 504.0 4.0 0.918260869565217 M 274.0 301.0 4.0 0.500869565217391 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 575.0 0.4765217391304348 0.5234782608695652 0.177658965657316 0.740595042417794 0.4591270040375549 0.562936076760478 0 0 0 0 K04043 0.6057142857142858 0.9829059829059827 dnaK, HSPA9; molecular chaperone DnaK path:map03018,path:map04212,path:map05152 RNA degradation,Longevity regulating pathway - worm,Tuberculosis 356.0 725.0 721.0 5.0 0.989085948158254 O 241.0 492.0 8.0 0.978171896316508 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 733.0 0.3287858117326057 0.6712141882673943 0.0768413158499521 0.303930995888926 0.190386155869439 0.2270896800389739 0 0 0 0 K04044 0.0 0.0854700854700854 hscA; molecular chaperone HscA 538.0 30.0 0.0 1.0 1.0 O 0.0 30.0 1.0 1.0 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 30.0 0.0 1.0 0.0082000182159765 0.0283732891185942 0.0182866536672853 0.0201732709026177 0 0 0 0 K04045 0.0 0.0256410256410256 hscC; molecular chaperone HscC 530.0 9.0 0.0 1.0 1.0 O 0.0 9.0 1.0 1.0 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 9.0 0.0 1.0 0.130699257583334 0.360824248052741 0.2457617528180375 0.230124990469407 0 0 0 0 K04046 0.0 0.131054131054131 yegD; hypothetical chaperone protein 286.0 49.0 0.0 1.0 1.0 O 0.0 49.0 1.0 1.0 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 49.0 0.0 1.0 0.0069394553327904 0.0146084664343891 0.0107739608835897 0.0076690111015987 0 0 0 0 K04047 0.1457142857142857 0.4074074074074074 dps; starvation-inducible DNA-binding protein 84.0 270.0 267.0 2.0 0.989010989010989 P 70.0 203.0 1.0 1.0 COG0783 DNA-binding_ferritin-like_protein_(oxidative_damage_protectant) Dps 273.0 0.2564102564102564 0.7435897435897436 0.0026924149436233 0.0212844755853207 0.011988445264472 0.0185920606416973 0 0 0 0 K04054 0.0 0.0028490028490028 yscK, sctK; type III secretion protein K 223.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2E6VV 1.0 0.0 1.0 0 0 0 0 K04055 0.0 0.0028490028490028 yscM, sctM; type III secretion protein M 824.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG5599 Protein_tyrosine_phosphatase 2.0 0.0 1.0 0 0 0 0 K04058 0.0 0.0113960113960113 yscW, sctW; type III secretion protein W path:map03070 Bacterial secretion system 307.0 6.0 0.0 1.0 1.0 S 0.0 6.0 4.0 0.333333333333333 28KVC 6.0 0.0 1.0 1.58897518998901e-06 0.0011007047186337 0.0005511468469118 0.0010991157434437 0 0 0 0 K04059 0.0 0.0028490028490028 yscX, sctX; type III secretion protein X path:map03070 Bacterial secretion system 126.0 0.0 1.0 1.0 1.0 28WST 1.0 0.0 1.0 0 0 0 0 K04061 0.0 0.2307692307692307 flhB2; flagellar biosynthesis protein 71.0 53.0 23.0 3.0 0.630952380952381 S 0.0 84.0 2.0 0.952380952380952 COG2257 Type_III_secretion_system_substrate_exporter,_FlhB-like YlqH 84.0 0.0 1.0 0.0139534669675489 0.37114234978938 0.1925479083784644 0.3571888828218311 0 0 0 0 K04062 0.0 0.0199430199430199 osmB; osmotically inducible lipoprotein OsmB 64.0 6.0 1.0 2.0 0.545454545454545 M 0.0 11.0 7.0 0.454545454545455 2CMW8 11.0 0.0 1.0 0.0133714861003527 0.021297284521165 0.0173343853107588 0.0079257984208123 0 0 0 0 K04063 0.0742857142857142 0.1908831908831909 osmC, ohr; lipoyl-dependent peroxiredoxin [EC:1.11.1.28] 104.0 110.0 0.0 1.0 1.0 O 29.0 81.0 2.0 0.918181818181818 COG1764 Organic_hydroperoxide_reductase_OsmC/OhrA OsmC 110.0 0.2636363636363636 0.7363636363636363 0.0277650414716715 0.578525337035445 0.3031451892535582 0.5507602955637735 0 0 0 0 K04064 0.0 0.0227920227920227 osmE; osmotically inducible lipoprotein OsmE 77.0 8.0 7.0 2.0 0.888888888888889 J 0.0 9.0 1.0 1.0 COG2913 Outer_membrane_protein_assembly_factor_BamE,_lipoprotein_component_of_the_BamABCDE_complex BamE 9.0 0.0 1.0 0.0373194614588081 0.090906382169882 0.064112921814345 0.0535869207110739 0 0 0 0 K04065 0.0 0.1168091168091168 osmY; hyperosmotically inducible periplasmic protein 56.0 48.0 46.0 2.0 0.96 S 0.0 50.0 2.0 0.98 COG2823 Osmotically-inducible_protein_OsmY,_contains_BON_domain OsmY 50.0 0.0 1.0 0.0070126492695851 0.119283877716993 0.063148263493289 0.1122712284474079 0 0 0 0 K04066 0.0085714285714285 0.9173789173789174 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] path:map03440 Homologous recombination 213.0 337.0 334.0 5.0 0.979651162790698 L 3.0 341.0 7.0 0.973837209302326 COG1198 Primosomal_protein_N'_(replication_factor_Y)_-_superfamily_II_helicase PriA 344.0 0.0087209302325581 0.9912790697674418 0.001176892168161 0.0098914307860135 0.0055341614770872 0.0087145386178525 0 0 0 0 K04067 0.0 0.017094017094017 priC; primosomal replication protein N'' path:map03440 Homologous recombination 164.0 6.0 0.0 1.0 1.0 L 0.0 6.0 1.0 1.0 COG3923 Primosomal_replication_protein_N'' PriC 6.0 0.0 1.0 4.38034859512361e-12 7.82967891192196e-08 3.915058473390736e-08 7.829240877062448e-08 0 0 0 0 K04068 0.0171428571428571 0.2421652421652421 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] 62.0 60.0 32.0 3.0 0.535714285714286 O 6.0 106.0 3.0 0.919642857142857 COG0602 Organic_radical_activating_enzyme_NrdG/QueE QueE 112.0 0.0535714285714285 0.9464285714285714 0.0328921053172178 0.509833117653402 0.2713626114853099 0.4769410123361842 0 0 0 0 K04069 0.6714285714285714 0.5470085470085471 pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4] 30.0 675.0 367.0 7.0 0.675 C 612.0 381.0 6.0 0.963 COG1180 Pyruvate-formate_lyase-activating_enzyme PflA 993.0 0.6163141993957704 0.3836858006042296 0.730695875445107 0.523522766482537 0.627109320963822 0.2071731089625699 0 1 0 1 K04070 0.3742857142857143 0.1994301994301994 pflX; putative pyruvate formate lyase activating enzyme [EC:1.97.1.4] 183.0 197.0 164.0 2.0 0.856521739130435 C 141.0 89.0 1.0 1.0 COG1313 Radical_SAM_superfamily_enzyme_PflX PflX 230.0 0.6130434782608696 0.3869565217391304 0.913143751317655 0.822865280734609 0.868004516026132 0.090278470583046 1 1 1 1 K04072 0.0371428571428571 0.1595441595441595 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] path:map00010,path:map00071,path:map00350,path:map00620,path:map00625,path:map00626,path:map00650,path:map01100,path:map01110,path:map01120,path:map01220,path:map05146 Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Naphthalene degradation,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds,Amoebiasis 333.0 84.0 0.0 1.0 1.0 C 14.0 66.0 2.0 0.797619047619048 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 80.0 0.175 0.825 0.0111620515664409 0.258238729072525 0.1347003903194829 0.247076677506084 0 0 0 0 K04073 0.0 0.0911680911680911 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10] path:map00360,path:map00362,path:map00620,path:map00621,path:map00622,path:map00650,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Benzoate degradation,Pyruvate metabolism,Dioxin degradation,Xylene degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 275.0 41.0 38.0 2.0 0.931818181818182 Q 0.0 44.0 1.0 1.0 COG4569 Acetaldehyde_dehydrogenase_(acetylating) MhpF 44.0 0.0 1.0 0.0008052956290745 0.175753658036354 0.0882794768327142 0.1749483624072795 0 0 0 0 K04074 0.0 0.2706552706552707 divIVA; cell division initiation protein 73.0 95.0 94.0 2.0 0.989583333333333 D 0.0 96.0 2.0 0.989583333333333 COG3599 Cell_division_septum_initiation_protein_DivIVA,_interacts_with_FtsZ_and_MinD DivIVA 96.0 0.0 1.0 0.026544934473938 0.612480703447699 0.3195128189608185 0.585935768973761 0 0 0 0 K04075 0.0171428571428571 0.9088319088319088 tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] 34.0 250.0 168.0 9.0 0.708215297450425 D 7.0 341.0 3.0 0.98300283286119 COG0037 tRNA(Ile)-lysidine_synthase_TilS/MesJ TilS 348.0 0.0201149425287356 0.9798850574712644 0.0388538768276261 0.217508543809688 0.128181210318657 0.1786546669820619 0 0 0 0 K04076 0.5885714285714285 0.1566951566951566 lonB; ATP-dependent Lon protease [EC:3.4.21.53] 405.0 271.0 262.0 5.0 0.937716262975779 O 220.0 70.0 10.0 0.741379310344828 COG0466 ATP-dependent_Lon_protease,_bacterial_type Lon 290.0 0.7586206896551724 0.2413793103448276 0.798990215822265 0.89660905519492 0.8477996355085925 0.0976188393726549 1 1 1 1 K04077 0.0828571428571428 0.9658119658119658 groEL, HSPD1; chaperonin GroEL path:map03018,path:map04212,path:map04940,path:map05134,path:map05152,path:map05417 RNA degradation,Longevity regulating pathway - worm,Type I diabetes mellitus,Legionellosis,Tuberculosis,Lipid and atherosclerosis 461.0 477.0 476.0 3.0 0.995824634655532 O 29.0 450.0 3.0 0.995824634655532 COG0459 Chaperonin_GroEL_(HSP60_family) GroEL 479.0 0.0605427974947807 0.9394572025052192 0.984374413585518 0.987719206095656 0.986046809840587 0.0033447925101379 1 1 1 1 K04078 0.0828571428571428 0.9572649572649572 groES, HSPE1; chaperonin GroES 54.0 441.0 438.0 2.0 0.993243243243243 O 29.0 415.0 1.0 1.0 COG0234 Co-chaperonin_GroES_(HSP10) GroES 444.0 0.0653153153153153 0.9346846846846848 0.0563064223413878 0.716737076028196 0.3865217491847919 0.6604306536868082 0 0 0 0 K04079 0.0314285714285714 0.5156695156695157 HSP90A, htpG; molecular chaperone HtpG path:map04141,path:map04151,path:map04217,path:map04612,path:map04621,path:map04626,path:map04657,path:map04659,path:map04914,path:map04915,path:map05132,path:map05200,path:map05207,path:map05215,path:map05417,path:map05418 Protein processing in endoplasmic reticulum,PI3K-Akt signaling pathway,Necroptosis,Antigen processing and presentation,NOD-like receptor signaling pathway,Plant-pathogen interaction,IL-17 signaling pathway,Th17 cell differentiation,Progesterone-mediated oocyte maturation,Estrogen signaling pathway,Salmonella infection,Pathways in cancer,Chemical carcinogenesis - receptor activation,Prostate cancer,Lipid and atherosclerosis,Fluid shear stress and atherosclerosis 352.0 184.0 169.0 5.0 0.893203883495146 O 11.0 195.0 2.0 0.980582524271845 COG0326 Molecular_chaperone,_HSP90_family HtpG 206.0 0.0533980582524271 0.9466019417475728 0.0048390003226335 0.582705723238618 0.2937723617806257 0.5778667229159845 0 0 0 0 K04080 0.0 0.1082621082621082 ibpA; molecular chaperone IbpA 120.0 62.0 0.0 1.0 1.0 O 0.0 62.0 1.0 1.0 COG0071 Small_heat_shock_protein_IbpA,_HSP20_family IbpA 62.0 0.0 1.0 0.0028871878740535 0.0104616629584578 0.0066744254162556 0.0075744750844042 0 0 0 0 K04081 0.0 0.0028490028490028 ibpB; molecular chaperone IbpB 142.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0071 Small_heat_shock_protein_IbpA,_HSP20_family IbpA 1.0 0.0 1.0 0 0 0 0 K04082 0.0 0.1025641025641025 hscB, HSCB, HSC20; molecular chaperone HscB 102.0 37.0 0.0 1.0 1.0 O 0.0 37.0 2.0 0.783783783783784 COG1076 DnaJ_domain-containing_protein DjlA 37.0 0.0 1.0 0.0140343563240663 0.033967065634326 0.0240007109791961 0.0199327093102597 0 0 0 0 K04083 0.0 0.4387464387464387 hslO; molecular chaperone Hsp33 179.0 158.0 0.0 1.0 1.0 O 0.0 158.0 1.0 1.0 COG1281 Redox-regulated_molecular_chaperone,_HSP33_family HslO 158.0 0.0 1.0 0.004663104973239 0.0065208413697685 0.0055919731715037 0.0018577363965294 0 0 0 0 K04084 0.04 0.3846153846153846 dsbD, dipZ; thioredoxin:protein disulfide reductase [EC:1.8.4.16] 180.0 177.0 165.0 4.0 0.889447236180904 CO 15.0 180.0 5.0 0.884422110552764 COG4232 Thiol:disulfide_interchange_protein_DsbD DsbD 195.0 0.0769230769230769 0.9230769230769232 0.0058098658700937 0.0147146937447691 0.0102622798074314 0.0089048278746753 0 0 0 0 K04085 0.1428571428571428 0.2621082621082621 tusA, sirA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-] path:map04122 Sulfur relay system 45.0 176.0 167.0 3.0 0.936170212765957 O 72.0 112.0 5.0 0.952380952380952 COG0425 Sulfur_carrier_protein_TusA_(tRNA_thiolation,_molybdenum_cofactor_biosynthesis) TusA 184.0 0.391304347826087 0.6086956521739131 0.38344781723638 0.814974383605977 0.5992111004211784 0.4315265663695969 0 0 0 0 K04086 0.0 0.0199430199430199 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL 666.0 7.0 0.0 1.0 1.0 O 0.0 7.0 1.0 1.0 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 7.0 0.0 1.0 0.0355840009892513 0.145009634152208 0.0902968175707296 0.1094256331629567 0 0 0 0 K04087 0.0 0.3247863247863248 hflC; modulator of FtsH protease HflC 223.0 119.0 116.0 2.0 0.975409836065574 O 0.0 122.0 2.0 0.975409836065574 COG0330 Regulator_of_protease_activity_HflC,_stomatin/prohibitin_superfamily HflC 122.0 0.0 1.0 0.114714454939888 0.0982237706004969 0.1064691127701924 0.016490684339391 0 0 0 0 K04088 0.0228571428571428 0.3361823361823361 hflK; modulator of FtsH protease HflK 206.0 120.0 104.0 2.0 0.882352941176471 O 8.0 128.0 2.0 0.875 COG0330 Regulator_of_protease_activity_HflC,_stomatin/prohibitin_superfamily HflC 136.0 0.0588235294117647 0.9411764705882352 0.393882891371327 0.143176852358982 0.2685298718651545 0.250706039012345 0 0 0 0 K04090 0.0228571428571428 0.1367521367521367 E1.2.7.8; indolepyruvate ferredoxin oxidoreductase [EC:1.2.7.8] 823.0 66.0 0.0 1.0 1.0 C 9.0 57.0 2.0 0.818181818181818 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 66.0 0.1363636363636363 0.8636363636363636 0.185723619067837 0.174926597064704 0.1803251080662705 0.0107970220031329 0 0 0 0 K04091 0.0028571428571428 0.1396011396011396 ssuD, msuD; alkanesulfonate monooxygenase [EC:1.14.14.5 1.14.14.34] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 234.0 95.0 94.0 2.0 0.989583333333333 C 1.0 95.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 96.0 0.0104166666666666 0.9895833333333334 0.0181502441744364 0.179739747053614 0.0989449956140252 0.1615895028791776 0 0 0 0 K04092 0.0085714285714285 0.1282051282051282 tyrA1; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 79.0 51.0 0.0 1.0 1.0 E 3.0 48.0 4.0 0.745098039215686 COG1605 Chorismate_mutase PheA 51.0 0.0588235294117647 0.9411764705882352 0.403936448550579 0.491667217080978 0.4478018328157784 0.087730768530399 0 0 0 0 K04093 0.2828571428571428 0.0911680911680911 pheA1; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 64.0 132.0 128.0 3.0 0.949640287769784 E 101.0 38.0 4.0 0.884892086330935 COG1605 Chorismate_mutase PheA 139.0 0.7266187050359713 0.2733812949640288 0.860106565135809 0.45964633067196 0.6598764479038844 0.400460234463849 1 1 1 1 K04094 0.0 0.3675213675213675 trmFO, gid; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] 377.0 137.0 135.0 2.0 0.985611510791367 J 0.0 140.0 1.0 1.0 COG1206 Folate-dependent_tRNA-U54_methylase_TrmFO/GidA TrmFO 140.0 0.0 1.0 0.991053342962776 0.837304461881221 0.9141789024219984 0.153748881081555 0 0 1 1 K04095 0.0057142857142857 0.1282051282051282 fic; cell filamentation protein 73.0 53.0 0.0 1.0 1.0 D 3.0 50.0 2.0 0.981132075471698 COG2184 Fido,_protein-threonine_AMPylation_domain FIDO 53.0 0.0566037735849056 0.9433962264150944 0.123118858977272 0.231977782562458 0.177548320769865 0.108858923585186 0 0 0 0 K04096 0.0942857142857142 0.9344729344729344 smf; DNA processing protein 50.0 307.0 223.0 7.0 0.720657276995305 LU 41.0 396.0 8.0 0.844393592677346 COG0758 Predicted_Rossmann_fold_nucleotide-binding_protein_DprA/Smf_involved_in_DNA_uptake Smf 437.0 0.0938215102974828 0.9061784897025172 0.562810119485079 0.494813466706885 0.5288117930959819 0.067996652778194 0 1 0 1 K04097 0.0142857142857142 0.0056980056980056 HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18] path:map00480,path:map00590,path:map00980,path:map00982,path:map01100,path:map05204 Glutathione metabolism,Arachidonic acid metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Metabolic pathways,Chemical carcinogenesis - DNA adducts 204.0 7.0 0.0 1.0 1.0 O 5.0 2.0 2.0 0.714285714285714 KOG1695 7.0 0.7142857142857143 0.2857142857142857 0.0292830264040849 0.063299338152343 0.0462911822782139 0.034016311748258 0 0 0 0 K04098 0.0 0.017094017094017 chqB; hydroxyquinol 1,2-dioxygenase [EC:1.13.11.37] path:map00361,path:map00362,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 278.0 9.0 0.0 1.0 1.0 Q 0.0 9.0 1.0 1.0 COG3485 Protocatechuate_3,4-dioxygenase_beta_subunit PcaH 9.0 0.0 1.0 0.0030565537739162 0.0092908541436138 0.006173703958765 0.0062343003696976 0 0 0 0 K04099 0.0 0.0284900284900284 desB, galA; gallate dioxygenase [EC:1.13.11.57] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 277.0 8.0 6.0 2.0 0.8 S 0.0 10.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 10.0 0.0 1.0 0.0244479540097516 0.0519100510477889 0.0381790025287702 0.0274620970380372 0 0 0 0 K04100 0.0 0.0341880341880341 ligA; protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8] path:map00362,path:map00624,path:map00627,path:map01100,path:map01120 Benzoate degradation,Polycyclic aromatic hydrocarbon degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 112.0 15.0 14.0 2.0 0.9375 S 0.0 16.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 16.0 0.0 1.0 0.0325963505188941 0.0772508689334224 0.0549236097261582 0.0446545184145283 0 0 0 0 K04101 0.0142857142857142 0.0569800569800569 ligB; protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8] path:map00362,path:map00624,path:map00627,path:map01100,path:map01120 Benzoate degradation,Polycyclic aromatic hydrocarbon degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 142.0 16.0 9.0 3.0 0.571428571428571 S 5.0 23.0 3.0 0.535714285714286 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 28.0 0.1785714285714285 0.8214285714285714 0.0459217267083274 0.15308793968516 0.0995048331967436 0.1071662129768326 0 0 0 0 K04102 0.0 0.017094017094017 pht5; 4,5-dihydroxyphthalate decarboxylase [EC:4.1.1.55] path:map00624,path:map01100,path:map01120 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments 324.0 8.0 0.0 1.0 1.0 P 0.0 8.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 8.0 0.0 1.0 0.0175624699153013 0.0385368524415504 0.0280496611784258 0.020974382526249 0 0 0 0 K04103 0.0085714285714285 0.0512820512820512 ipdC; indolepyruvate decarboxylase [EC:4.1.1.74] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 461.0 12.0 4.0 3.0 0.545454545454545 GH 3.0 19.0 1.0 1.0 COG3961 TPP-dependent_2-oxoacid_decarboxylase,_includes_indolepyruvate_decarboxylase PDC1 22.0 0.1363636363636363 0.8636363636363636 0.0700607395572598 0.213332168203531 0.1416964538803954 0.1432714286462711 0 0 0 0 K04105 0.0 0.0142450142450142 hbaA; 4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25] path:map00362,path:map00627,path:map01100,path:map01120,path:map01220 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 507.0 5.0 0.0 1.0 1.0 I 0.0 5.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 5.0 0.0 1.0 0.0216761945407905 0.212199243940268 0.1169377192405292 0.1905230493994775 0 0 0 0 K04107 0.0028571428571428 0.0056980056980056 hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1] path:map00362,path:map00627,path:map01100,path:map01120,path:map01220 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 152.0 3.0 0.0 1.0 1.0 C 1.0 2.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K04108 0.0314285714285714 0.0227920227920227 hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1] path:map00362,path:map00627,path:map01100,path:map01120,path:map01220 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 756.0 20.0 0.0 1.0 1.0 C 11.0 9.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 20.0 0.55 0.45 0.0453509933156795 0.0122414289514232 0.0287962111335513 0.0331095643642563 0 0 0 0 K04109 0.0171428571428571 0.0142450142450142 hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1] path:map00362,path:map00627,path:map01100,path:map01120,path:map01220 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 316.0 12.0 0.0 1.0 1.0 C 6.0 6.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 12.0 0.5 0.5 0.0184885970208603 0.018492523204118 0.0184905601124891 3.926183257701998e-06 0 0 0 0 K04110 0.0 0.0427350427350427 badA; benzoate-CoA ligase [EC:6.2.1.25] path:map00362,path:map00627,path:map01100,path:map01120 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 492.0 18.0 0.0 1.0 1.0 I 0.0 18.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 18.0 0.0 1.0 0.0168238544571161 0.302554941213902 0.159689397835509 0.2857310867567859 0 0 0 0 K04112 0.0457142857142857 0.037037037037037 bcrC, badD; benzoyl-CoA reductase subunit C [EC:1.3.7.8] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 286.0 34.0 0.0 1.0 1.0 E 19.0 15.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 34.0 0.5588235294117647 0.4411764705882353 0.476528362913207 0.917290074732046 0.6969092188226265 0.440761711818839 0 0 0 0 K04113 0.0514285714285714 0.0284900284900284 bcrB, badE; benzoyl-CoA reductase subunit B [EC:1.3.7.8] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 271.0 33.0 0.0 1.0 1.0 E 19.0 14.0 2.0 0.96969696969697 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 33.0 0.5757575757575758 0.4242424242424242 0.547567335598217 0.921818204121524 0.7346927698598705 0.374250868523307 0 1 0 1 K04114 0.0314285714285714 0.0085470085470085 bcrA, badF; benzoyl-CoA reductase subunit A [EC:1.3.7.8] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 242.0 15.0 14.0 2.0 0.9375 I 12.0 4.0 2.0 0.9375 COG1924 Activator_of_2-hydroxyglutaryl-CoA_dehydratase_(HSP70-class_ATPase_domain) YjiL 16.0 0.75 0.25 1.69156203904147e-05 0.0187257144917601 0.0093713150560752 0.0187087988713696 0 0 0 0 K04115 0.0285714285714285 0.0085470085470085 bcrD, badG; benzoyl-CoA reductase subunit D [EC:1.3.7.8] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 234.0 12.0 11.0 2.0 0.923076923076923 I 10.0 3.0 1.0 1.0 COG1924 Activator_of_2-hydroxyglutaryl-CoA_dehydratase_(HSP70-class_ATPase_domain) YjiL 13.0 0.7692307692307693 0.2307692307692307 0.0688434899411414 0.612622608594973 0.3407330492680572 0.5437791186538316 0 0 0 0 K04116 0.0 0.0598290598290598 aliA; cyclohexanecarboxylate-CoA ligase [EC:6.2.1.-] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 458.0 26.0 0.0 1.0 1.0 IQ 0.0 26.0 2.0 0.961538461538462 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 26.0 0.0 1.0 0.0068522467854002 0.0315314663815724 0.0191918565834863 0.0246792195961722 0 0 0 0 K04117 0.0114285714285714 0.0227920227920227 aliB; cyclohexanecarboxyl-CoA dehydrogenase [EC:1.3.99.-] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 378.0 14.0 13.0 2.0 0.933333333333333 I 4.0 11.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 15.0 0.2666666666666666 0.7333333333333333 0.0028830216844405 0.0127763871585645 0.0078297044215025 0.009893365474124 0 0 0 0 K04118 0.0 0.0028490028490028 E1.3.1.62; pimeloyl-CoA dehydrogenase [EC:1.3.1.62] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 339.0 1.0 0.0 2.0 0.5 I 0.0 2.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 2.0 0.0 1.0 0 0 0 0 K04120 0.0085714285714285 0.0 E5.5.1.13; ent-copalyl diphosphate synthase [EC:5.5.1.13] path:map00904,path:map01100,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 448.0 3.0 0.0 1.0 1.0 S 3.0 0.0 1.0 1.0 2CKJS 3.0 1.0 0.0 0 0 0 0 K04121 0.0028571428571428 0.0 E4.2.3.19; ent-kaurene synthase [EC:4.2.3.19] path:map00904,path:map01100,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 489.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2CKJS 1.0 1.0 0.0 0 0 0 0 K04127 0.0342857142857142 0.1025641025641025 cefD; isopenicillin-N epimerase [EC:5.1.1.17] path:map00311,path:map01100,path:map01110 Penicillin and cephalosporin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 260.0 47.0 44.0 3.0 0.903846153846154 E 12.0 40.0 1.0 1.0 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 52.0 0.2307692307692307 0.7692307692307693 0.0254505409483593 0.238158069934678 0.1318043054415186 0.2127075289863187 0 0 0 0 K04128 0.0 0.0028490028490028 cmcH; hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7] path:map00311,path:map01100,path:map01110 Penicillin and cephalosporin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 522.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG2192 Predicted_carbamoyl_transferase,_NodU_family 1.0 0.0 1.0 0 0 0 0 K04324 0.0028571428571428 0.0 MAS1L; Mas-related G-protein coupled receptor MRG 70.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1383 Ribosomal_protein_S17E RPS17A 1.0 1.0 0.0 0 0 0 0 K04333 0.0 0.0199430199430199 csgD; LuxR family transcriptional regulator, csgAB operon transcriptional regulatory protein path:map02026 Biofilm formation - Escherichia coli 92.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 8.0 0.0 1.0 0.0355827466683088 0.0630145180530325 0.0492986323606706 0.0274317713847236 0 0 0 0 K04334 0.0 0.0056980056980056 csgA; major curlin subunit path:map02026 Biofilm formation - Escherichia coli 129.0 1.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 29Z81 2.0 0.0 1.0 0 0 0 0 K04335 0.0 0.0142450142450142 csgB; minor curlin subunit path:map02026 Biofilm formation - Escherichia coli 129.0 2.0 0.0 1.0 1.0 S 0.0 5.0 5.0 0.2 29X1N 5.0 0.0 1.0 0.0153066303443206 0.0340199482193535 0.024663289281837 0.0187133178750329 0 0 0 0 K04336 0.0 0.0028490028490028 csgC; curli production protein path:map02026 Biofilm formation - Escherichia coli 110.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 2CHEZ 1.0 0.0 1.0 0 0 0 0 K04337 0.0 0.017094017094017 csgE; curli production assembly/transport component CsgE 104.0 6.0 0.0 1.0 1.0 S 0.0 6.0 3.0 0.333333333333333 2C2E6 6.0 0.0 1.0 0.0294011182121417 0.0723988426094288 0.0508999804107852 0.0429977243972871 0 0 0 0 K04338 0.0 0.0256410256410256 csgF; curli production assembly/transport component CsgF 114.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 2DEP1 9.0 0.0 1.0 0.0085424157183 0.0231853438742655 0.0158638797962827 0.0146429281559655 0 0 0 0 K04339 0.0 0.0028490028490028 stsE; scyllo-inosamine 4-kinase [EC:2.7.1.65] path:map00521,path:map01110 Streptomycin biosynthesis,Biosynthesis of secondary metabolites 320.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 1.0 0.0 1.0 0 0 0 0 K04342 0.0 0.0085470085470085 strK; streptomycin-6-phosphatase [EC:3.1.3.39] path:map00521,path:map01100,path:map01110 Streptomycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 119.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG1785 Alkaline_phosphatase PhoA 3.0 0.0 1.0 0 0 0 0 K04343 0.0 0.0797720797720797 strB; streptomycin 6-kinase [EC:2.7.1.72] 161.0 27.0 24.0 4.0 0.794117647058823 V 0.0 34.0 3.0 0.882352941176471 COG3570 Streptomycin_6-kinase StrB 34.0 0.0 1.0 0.0348379097197137 0.0628674018785594 0.0488526557991365 0.0280294921588456 0 0 0 0 K04353 0.0057142857142857 0.0 RAP1A; Ras-related protein Rap-1A path:map04010,path:map04014,path:map04015,path:map04024,path:map04062,path:map04510,path:map04530,path:map04611,path:map04670,path:map04720,path:map04722,path:map04934,path:map04972,path:map05211,path:map05417 MAPK signaling pathway,Ras signaling pathway,Rap1 signaling pathway,cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion,Tight junction,Platelet activation,Leukocyte transendothelial migration,Long-term potentiation,Neurotrophin signaling pathway,Cushing syndrome,Pancreatic secretion,Renal cell carcinoma,Lipid and atherosclerosis 91.0 1.0 0.0 2.0 0.5 G 2.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 2.0 1.0 0.0 0 0 0 0 K04367 0.0028571428571428 0.0 MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1] path:map04114,path:map04810,path:map04914 Oocyte meiosis,Regulation of actin cytoskeleton,Progesterone-mediated oocyte maturation 234.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG0515 Serine/threonine_protein_kinase SPS1 1.0 1.0 0.0 0 0 0 0 K04437 0.0 0.0028490028490028 FLNA; filamin path:map04010,path:map04510,path:map05132,path:map05205 MAPK signaling pathway,Focal adhesion,Salmonella infection,Proteoglycans in cancer 25.0 2.0 0.0 1.0 1.0 Z 0.0 2.0 1.0 1.0 COG5069 2.0 0.0 1.0 0 0 0 0 K04459 0.0057142857142857 0.0056980056980056 DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48] path:map04010,path:map04361 MAPK signaling pathway,Axon regeneration 133.0 3.0 2.0 2.0 0.75 T 2.0 2.0 1.0 1.0 COG2453 Protein-tyrosine_phosphatase CDC14 4.0 0.5 0.5 0.0223683960873905 0.0503316197235209 0.0363500079054557 0.0279632236361303 0 0 0 0 K04469 0.0 0.0028490028490028 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 path:map04010,path:map04064,path:map04380,path:map04625,path:map05134,path:map05166,path:map05169,path:map05200,path:map05203,path:map05224 MAPK signaling pathway,NF-kappa B signaling pathway,Osteoclast differentiation,C-type lectin receptor signaling pathway,Legionellosis,Human T-cell leukemia virus 1 infection,Epstein-Barr virus infection,Pathways in cancer,Viral carcinogenesis,Breast cancer 303.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K04477 0.1914285714285714 0.1652421652421652 ycdX; putative hydrolase 92.0 110.0 67.0 2.0 0.718954248366013 E 80.0 70.0 2.0 0.816993464052288 COG1387 Histidinol_phosphatase_or_related_hydrolase_of_the_PHP_family HIS2 150.0 0.5333333333333333 0.4666666666666667 0.73861317390715 0.840983657277821 0.7897984155924855 0.102370483370671 0 1 0 1 K04478 0.0 0.0142450142450142 sgtB; monofunctional glycosyltransferase [EC:2.4.1.129] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 232.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 5.0 0.0 1.0 0.485516815641877 0.200521225132005 0.343019020386941 0.284995590509872 0 0 0 0 K04479 0.3514285714285714 0.0199430199430199 dbh; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7] 274.0 143.0 0.0 1.0 1.0 L 136.0 7.0 1.0 1.0 COG0389 Nucleotidyltransferase/DNA_polymerase_DinP_involved_in_DNA_repair DinP 143.0 0.951048951048951 0.0489510489510489 0.0060934387040639 0.0598005242057121 0.032946981454888 0.0537070855016482 0 0 0 0 K04480 0.0828571428571428 0.0028490028490028 mtaB; methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase [EC:2.1.1.90] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 438.0 54.0 0.0 1.0 1.0 H 53.0 1.0 1.0 1.0 arCOG03330 54.0 0.9814814814814816 0.0185185185185185 0.0370203537000784 0.01008573587278 0.0235530447864291 0.0269346178272983 0 0 0 0 K04482 0.0742857142857142 0.0 RAD51; DNA repair protein RAD51 path:map03440,path:map03460,path:map05200,path:map05212 Homologous recombination,Fanconi anemia pathway,Pathways in cancer,Pancreatic cancer 99.0 16.0 6.0 2.0 0.615384615384615 L 26.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 26.0 1.0 0.0 0.361390201709597 0.50347539311226 0.4324327974109285 0.1420851914026629 0 0 0 0 K04483 0.9171428571428571 0.0 radA; DNA repair protein RadA 215.0 422.0 403.0 2.0 0.956916099773243 L 441.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 441.0 1.0 0.0 0.815951848881989 0.992669820761845 0.904310834821917 0.1767179718798559 0 0 1 1 K04484 0.6971428571428572 0.0 radB; DNA repair protein RadB 136.0 249.0 0.0 1.0 1.0 L 249.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 249.0 1.0 0.0 0.644797362299073 0.452107795452731 0.548452578875902 0.192689566846342 0 0 0 1 K04485 0.1685714285714285 0.8233618233618234 radA, sms; DNA repair protein RadA/Sms 248.0 235.0 152.0 3.0 0.652777777777778 O 64.0 296.0 3.0 0.830555555555556 COG1066 DNA_repair_protein_RadA/Sms,_contains_AAA+_ATPase_domain Sms 360.0 0.1777777777777777 0.8222222222222222 0.0614983817132474 0.154935872856097 0.1082171272846722 0.0934374911428496 0 0 0 0 K04486 0.1371428571428571 0.2507122507122507 E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 87.0 140.0 115.0 2.0 0.848484848484848 E 53.0 112.0 2.0 0.866666666666667 COG1387 Histidinol_phosphatase_or_related_hydrolase_of_the_PHP_family HIS2 165.0 0.3212121212121212 0.6787878787878788 0.45149762556993 0.66922431412835 0.5603609698491401 0.21772668855842 0 0 0 0 K04487 0.42 0.8888888888888888 iscS, NFS1; cysteine desulfurase [EC:2.8.1.7] path:map00730,path:map01100,path:map01240,path:map04122 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 174.0 656.0 590.0 4.0 0.881720430107527 E 205.0 539.0 6.0 0.932795698924731 COG1104 Cysteine_desulfurase/Cysteine_sulfinate_desulfinase_IscS_or_related_enzyme,_NifS_family NifS 744.0 0.2755376344086021 0.7244623655913979 0.391953295786066 0.795115602915814 0.59353444935094 0.4031623071297479 0 0 0 0 K04488 0.6342857142857142 0.6894586894586895 iscU, nifU; nitrogen fixation protein NifU and related proteins 50.0 549.0 540.0 5.0 0.951473136915078 C 268.0 308.0 7.0 0.927209705372617 COG0822 Fe-S_cluster_assembly_scaffold_protein_IscU,_NifU_family IscU 576.0 0.4652777777777778 0.5347222222222222 0.77248527602679 0.857058688915602 0.814771982471196 0.084573412888812 1 1 1 1 K04496 0.0085714285714285 0.0056980056980056 CTBP; C-terminal binding protein [EC:1.1.1.428] path:map04310,path:map04330,path:map05200,path:map05220 Wnt signaling pathway,Notch signaling pathway,Pathways in cancer,Chronic myeloid leukemia 311.0 5.0 0.0 1.0 1.0 CH 3.0 2.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 5.0 0.6 0.4 0.113195927696762 0.242352628405141 0.1777742780509515 0.1291567007083789 0 0 0 0 K04505 0.0028571428571428 0.0 PSEN1, PS1; presenilin 1 [EC:3.4.23.-] path:map04310,path:map04330,path:map04361,path:map04722,path:map05010,path:map05022,path:map05165 Wnt signaling pathway,Notch signaling pathway,Axon regeneration,Neurotrophin signaling pathway,Alzheimer disease,Pathways of neurodegeneration - multiple diseases,Human papillomavirus infection 327.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 KOG2736 1.0 1.0 0.0 0 0 0 0 K04506 0.0 0.0028490028490028 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27] path:map04013,path:map04115,path:map04120,path:map04310 MAPK signaling pathway - fly,p53 signaling pathway,Ubiquitin mediated proteolysis,Wnt signaling pathway 288.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K04515 0.0057142857142857 0.0 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] path:map04012,path:map04020,path:map04024,path:map04066,path:map04114,path:map04217,path:map04261,path:map04310,path:map04360,path:map04713,path:map04720,path:map04722,path:map04725,path:map04728,path:map04740,path:map04745,path:map04750,path:map04911,path:map04912,path:map04916,path:map04921,path:map04922,path:map04925,path:map04934,path:map04971,path:map05012,path:map05022,path:map05031,path:map05152,path:map05200,path:map05205,path:map05214,path:map05415,path:map05417 ErbB signaling pathway,Calcium signaling pathway,cAMP signaling pathway,HIF-1 signaling pathway,Oocyte meiosis,Necroptosis,Adrenergic signaling in cardiomyocytes,Wnt signaling pathway,Axon guidance,Circadian entrainment,Long-term potentiation,Neurotrophin signaling pathway,Cholinergic synapse,Dopaminergic synapse,Olfactory transduction,Phototransduction - fly,Inflammatory mediator regulation of TRP channels,Insulin secretion,GnRH signaling pathway,Melanogenesis,Oxytocin signaling pathway,Glucagon signaling pathway,Aldosterone synthesis and secretion,Cushing syndrome,Gastric acid secretion,Parkinson disease,Pathways of neurodegeneration - multiple diseases,Amphetamine addiction,Tuberculosis,Pathways in cancer,Proteoglycans in cancer,Glioma,Diabetic cardiomyopathy,Lipid and atherosclerosis 120.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG0033 2.0 1.0 0.0 0 0 0 0 K04516 0.0 0.0 AROA1, aroA; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 81.0 77.0 2.0 0.952941176470588 E 0.0 0.0 4.0 0.447058823529412 COG1605 Chorismate_mutase PheA 0.0 0 0 0 0 K04517 0.4371428571428571 0.6239316239316239 tyrA2; prephenate dehydrogenase [EC:1.3.1.12] path:map00400,path:map00401,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 67.0 310.0 238.0 2.0 0.81151832460733 E 159.0 233.0 5.0 0.599489795918367 COG0287 Prephenate_dehydrogenase TyrA 392.0 0.4056122448979591 0.5943877551020408 0.267139195456753 0.514010139503191 0.390574667479972 0.2468709440464379 0 0 0 0 K04518 0.42 0.5299145299145299 pheA2; prephenate dehydratase [EC:4.2.1.51] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 150.0 342.0 0.0 1.0 1.0 E 148.0 194.0 2.0 0.997076023391813 COG0077 Prephenate_dehydratase PheA2 342.0 0.4327485380116959 0.5672514619883041 0.624758515938331 0.950308243668119 0.7875333798032249 0.3255497277297879 0 1 0 1 K04523 0.0028571428571428 0.0 UBQLN, DSK2; ubiquilin path:map04141,path:map05014 Protein processing in endoplasmic reticulum,Amyotrophic lateral sclerosis 77.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5272 Ubiquitin UBI4 1.0 1.0 0.0 0 0 0 0 K04525 0.0 0.0028490028490028 SERPINA; serpin A 859.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG4826 Serine_protease_inhibitor SERPIN 1.0 0.0 1.0 0 0 0 0 K04552 0.0028571428571428 0.0 UBE2L3, UBCH7; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23] path:map04120,path:map05012,path:map05022 Ubiquitin mediated proteolysis,Parkinson disease,Pathways of neurodegeneration - multiple diseases 176.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 1.0 1.0 0.0 0 0 0 0 K04561 0.0942857142857142 0.131054131054131 norB; nitric oxide reductase subunit B [EC:1.7.2.5] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 375.0 66.0 41.0 2.0 0.725274725274725 P 36.0 55.0 1.0 1.0 COG3256 Nitric_oxide_reductase_large_subunit NorB 91.0 0.3956043956043956 0.6043956043956044 0.0261770004195526 0.029338842507034 0.0277579214632932 0.0031618420874813 0 0 0 0 K04562 0.0057142857142857 0.3361823361823361 flhG, fleN; flagellar biosynthesis protein FlhG 125.0 147.0 138.0 3.0 0.936305732484076 D 2.0 155.0 2.0 0.993630573248408 COG0455 MinD-like_ATPase_FlhG/YlxH,_activator_of_the_FlhF-type_GTPase FlhG 157.0 0.0127388535031847 0.9872611464968152 0.224889190407305 0.61000117143367 0.4174451809204875 0.385111981026365 0 0 0 0 K04564 0.4914285714285714 0.6951566951566952 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1] path:map04013,path:map04068,path:map04146,path:map04211,path:map04212,path:map04213,path:map05016,path:map05208,path:map05417 MAPK signaling pathway - fly,FoxO signaling pathway,Peroxisome,Longevity regulating pathway,Longevity regulating pathway - worm,Longevity regulating pathway - multiple species,Huntington disease,Chemical carcinogenesis - reactive oxygen species,Lipid and atherosclerosis 134.0 323.0 154.0 3.0 0.655172413793103 P 198.0 295.0 2.0 0.997971602434077 COG0605 Superoxide_dismutase SodA 493.0 0.4016227180527383 0.5983772819472617 0.003588251732082 0.0250258121209252 0.0143070319265035 0.0214375603888432 0 0 0 0 K04565 0.0085714285714285 0.2051282051282051 SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1] path:map04146,path:map04213,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05208 Peroxisome,Longevity regulating pathway - multiple species,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Chemical carcinogenesis - reactive oxygen species 48.0 83.0 79.0 3.0 0.932584269662921 P 3.0 86.0 3.0 0.955056179775281 COG2032 Cu/Zn_superoxide_dismutase SodC 89.0 0.0337078651685393 0.9662921348314608 0.0131282618560772 0.167434526408191 0.0902813941321341 0.1543062645521138 0 0 0 0 K04566 0.74 0.1623931623931624 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6] path:map00970 Aminoacyl-tRNA biosynthesis 231.0 327.0 326.0 2.0 0.996951219512195 J 267.0 61.0 3.0 0.948170731707317 COG1384 Lysyl-tRNA_synthetase,_class_I LysS 328.0 0.8140243902439024 0.1859756097560975 0.88687134452401 0.980169114200266 0.933520229362138 0.093297769676256 1 1 1 1 K04567 0.2285714285714285 0.8575498575498576 KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] path:map00970 Aminoacyl-tRNA biosynthesis 307.0 406.0 400.0 4.0 0.980676328502416 J 90.0 324.0 3.0 0.975845410628019 COG1190 Lysyl-tRNA_synthetase_(class_II) LysU 414.0 0.217391304347826 0.782608695652174 0.0024001088819563 0.0124089913081891 0.0074045500950727 0.0100088824262328 0 0 0 0 K04568 0.0228571428571428 0.2079772079772079 epmA, poxA; elongation factor P--(R)-beta-lysine ligase [EC:6.3.1.-] 210.0 75.0 68.0 2.0 0.914634146341463 J 8.0 74.0 2.0 0.75609756097561 COG2269 Elongation_factor_P--beta-lysine_ligase_(EF-P_beta-lysylation_pathway) EpmA 82.0 0.0975609756097561 0.902439024390244 0.0147813102281336 0.0271134832188009 0.0209473967234672 0.0123321729906673 0 0 0 0 K04608 0.0057142857142857 0.0 GRM6; metabotropic glutamate receptor 6 path:map04072,path:map04080,path:map04724 Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse 454.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG1056 2.0 1.0 0.0 0 0 0 0 K04612 0.0057142857142857 0.0 CASR; calcium-sensing receptor path:map04621,path:map04928 NOD-like receptor signaling pathway,Parathyroid hormone synthesis, secretion and action 454.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG1056 2.0 1.0 0.0 0 0 0 0 K04618 0.0085714285714285 0.017094017094017 GAOA; galactose oxidase [EC:1.1.3.9] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 61.0 10.0 8.0 2.0 0.833333333333333 S 4.0 8.0 5.0 0.416666666666667 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 12.0 0.3333333333333333 0.6666666666666666 0.0169773888321679 0.0675247597396208 0.0422510742858943 0.0505473709074529 0 0 0 0 K04641 0.0485714285714285 0.0028490028490028 bop; bacteriorhodopsin 232.0 24.0 0.0 1.0 1.0 S 23.0 1.0 1.0 1.0 COG5524 Bacteriorhodopsin 24.0 0.9583333333333334 0.0416666666666666 0.0053923251707661 0.0154960186033967 0.0104441718870814 0.0101036934326305 0 0 0 0 K04642 0.0514285714285714 0.0 hop; halorhodopsin 274.0 18.0 0.0 1.0 1.0 S 18.0 0.0 1.0 1.0 COG5524 Bacteriorhodopsin 18.0 1.0 0.0 0.0183747887395503 0.0287710414102592 0.0235729150749047 0.0103962526707089 0 0 0 0 K04643 0.0457142857142857 0.0 sop; sensory rhodopsin 229.0 20.0 0.0 1.0 1.0 S 20.0 0.0 1.0 1.0 COG5524 Bacteriorhodopsin 20.0 1.0 0.0 0.0046749818550338 0.0070213591990789 0.0058481705270563 0.0023463773440451 0 0 0 0 K04649 0.0228571428571428 0.0 HIP2, UBC1; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23] path:map04120 Ubiquitin mediated proteolysis 132.0 8.0 0.0 1.0 1.0 O 8.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 8.0 1.0 0.0 0.870964642288548 0.96095593667333 0.915960289480939 0.089991294384782 0 0 1 1 K04651 0.4 0.3276353276353276 hypA, hybF; hydrogenase nickel incorporation protein HypA/HybF 64.0 245.0 216.0 2.0 0.894160583941606 S 145.0 130.0 1.0 1.0 COG0375 Hydrogenase_maturation_factor_HypA/HybF,_metallochaperone_involved_in_Ni_insertion HybF 275.0 0.5272727272727272 0.4727272727272727 0.665374470614446 0.706771472197105 0.6860729714057755 0.041397001582659 0 1 0 1 K04652 0.3028571428571429 0.3219373219373219 hypB; hydrogenase nickel incorporation protein HypB 157.0 126.0 18.0 2.0 0.538461538461538 KO 108.0 127.0 1.0 1.0 COG0378 Hydrogenase/urease_maturation_factor_HypB,_Ni2+-binding_GTPase HypB 235.0 0.4595744680851064 0.5404255319148936 0.690211461372455 0.988990948068745 0.8396012047206001 0.2987794866962899 0 1 0 1 K04653 0.4114285714285714 0.3333333333333333 hypC; hydrogenase expression/formation protein HypC 25.0 288.0 282.0 2.0 0.979591836734694 O 150.0 144.0 2.0 0.989795918367347 COG0298 Hydrogenase_maturation_factor_HybG,_HypC/HupF_family HypC 294.0 0.5102040816326531 0.4897959183673469 0.873582823409684 0.871974912548145 0.8727788679789145 0.0016079108615389 1 1 1 1 K04654 0.3857142857142857 0.3190883190883191 hypD; hydrogenase expression/formation protein HypD 278.0 261.0 260.0 2.0 0.99618320610687 O 136.0 126.0 3.0 0.969465648854962 COG0409 Hydrogenase_maturation_factor_HypD HypD 262.0 0.5190839694656488 0.4809160305343511 0.88048002109788 0.949371543640499 0.9149257823691896 0.0688915225426189 1 1 1 1 K04655 0.5628571428571428 0.3447293447293447 hypE; hydrogenase expression/formation protein HypE 209.0 391.0 0.0 1.0 1.0 O 264.0 127.0 1.0 1.0 COG0309 Carbamoyl_dehydratase_HypE_(hydrogenase_maturation_factor) HypE 391.0 0.6751918158567775 0.3248081841432225 0.989235777368592 0.959989549064592 0.974612663216592 0.029246228304 1 1 1 1 K04656 0.4 0.3219373219373219 hypF; hydrogenase maturation protein HypF 417.0 271.0 268.0 2.0 0.989051094890511 O 146.0 128.0 3.0 0.974452554744526 COG0068 Hydrogenase_maturation_factor_HypF_(carbamoyltransferase) HypF 274.0 0.5328467153284672 0.4671532846715328 0.959613845847325 0.951924037171482 0.9557689415094036 0.007689808675843 1 1 1 1 K04688 0.0028571428571428 0.0 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1] path:map01521,path:map01522,path:map04012,path:map04066,path:map04140,path:map04150,path:map04151,path:map04152,path:map04211,path:map04212,path:map04213,path:map04350,path:map04361,path:map04371,path:map04666,path:map04714,path:map04910,path:map04931,path:map05131,path:map05163,path:map05165,path:map05170,path:map05200,path:map05205,path:map05207,path:map05210,path:map05212,path:map05221,path:map05224,path:map05225,path:map05226,path:map05231,path:map05235 EGFR tyrosine kinase inhibitor resistance,Endocrine resistance,ErbB signaling pathway,HIF-1 signaling pathway,Autophagy - animal,mTOR signaling pathway,PI3K-Akt signaling pathway,AMPK signaling pathway,Longevity regulating pathway,Longevity regulating pathway - worm,Longevity regulating pathway - multiple species,TGF-beta signaling pathway,Axon regeneration,Apelin signaling pathway,Fc gamma R-mediated phagocytosis,Thermogenesis,Insulin signaling pathway,Insulin resistance,Shigellosis,Human cytomegalovirus infection,Human papillomavirus infection,Human immunodeficiency virus 1 infection,Pathways in cancer,Proteoglycans in cancer,Chemical carcinogenesis - receptor activation,Colorectal cancer,Pancreatic cancer,Acute myeloid leukemia,Breast cancer,Hepatocellular carcinoma,Gastric cancer,Choline metabolism in cancer,PD-L1 expression and PD-1 checkpoint pathway in cancer 513.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 KOG0598 1.0 1.0 0.0 0 0 0 0 K04691 0.0028571428571428 0.0683760683760683 hhoB, degS; serine protease DegS [EC:3.4.21.-] 276.0 25.0 23.0 2.0 0.925925925925926 O 1.0 26.0 1.0 1.0 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 27.0 0.037037037037037 0.9629629629629628 0.0175047748505498 0.0939785334402016 0.0557416541453757 0.0764737585896518 0 0 0 0 K04708 0.0685714285714285 0.0142450142450142 KDSR; 3-dehydrosphinganine reductase [EC:1.1.1.102] path:map00600,path:map01100 Sphingolipid metabolism,Metabolic pathways 216.0 16.0 5.0 4.0 0.516129032258065 I 26.0 5.0 3.0 0.870967741935484 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 31.0 0.8387096774193549 0.1612903225806451 0.605986377866296 0.719021029151263 0.6625037035087795 0.1130346512849669 0 1 0 1 K04712 0.0 0.0142450142450142 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] path:map00600,path:map01100,path:map04071 Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway 302.0 5.0 0.0 1.0 1.0 I 0.0 5.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 5.0 0.0 1.0 0.0280380455142186 0.128565524312155 0.0783017849131868 0.1005274787979364 0 0 0 0 K04718 0.0171428571428571 0.0056980056980056 SPHK; sphingosine kinase [EC:2.7.1.91] path:map00600,path:map01100,path:map04020,path:map04071,path:map04072,path:map04370,path:map04371,path:map04666,path:map05152 Sphingolipid metabolism,Metabolic pathways,Calcium signaling pathway,Sphingolipid signaling pathway,Phospholipase D signaling pathway,VEGF signaling pathway,Apelin signaling pathway,Fc gamma R-mediated phagocytosis,Tuberculosis 294.0 8.0 0.0 1.0 1.0 I 6.0 2.0 1.0 1.0 COG1597 Phosphatidylglycerol_kinase,_diacylglycerol_kinase_family LCB5 8.0 0.75 0.25 0.009989424611561 0.0486029540699281 0.0292961893407445 0.0386135294583671 0 0 0 0 K04719 0.2485714285714285 0.1566951566951566 bluB; 5,6-dimethylbenzimidazole synthase [EC:1.13.11.79] path:map00740,path:map01100,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of cofactors 99.0 149.0 145.0 3.0 0.967532467532468 C 98.0 56.0 3.0 0.967532467532468 COG0778 Nitroreductase NfnB 154.0 0.6363636363636364 0.3636363636363636 0.92395841568091 0.967137219117885 0.9455478173993974 0.043178803436975 1 1 1 1 K04720 0.3885714285714285 0.2735042735042735 cobD; threonine-phosphate decarboxylase [EC:4.1.1.81] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 102.0 260.0 259.0 3.0 0.99236641221374 E 154.0 105.0 2.0 0.99618320610687 COG0079 Histidinol-phosphate/aromatic_aminotransferase_or_cobyric_acid_decarboxylase HisC 259.0 0.5945945945945946 0.4054054054054054 0.283762943744021 0.0186394465938339 0.1512011951689274 0.2651234971501871 0 0 0 0 K04734 0.0 0.0028490028490028 NFKBIA; NF-kappa-B inhibitor alpha path:map04024,path:map04062,path:map04064,path:map04210,path:map04380,path:map04620,path:map04621,path:map04622,path:map04623,path:map04624,path:map04625,path:map04657,path:map04658,path:map04659,path:map04660,path:map04662,path:map04668,path:map04722,path:map04920,path:map04926,path:map04931,path:map04936,path:map05120,path:map05130,path:map05131,path:map05132,path:map05134,path:map05135,path:map05140,path:map05142,path:map05145,path:map05160,path:map05161,path:map05162,path:map05163,path:map05164,path:map05166,path:map05167,path:map05168,path:map05169,path:map05170,path:map05171,path:map05200,path:map05203,path:map05208,path:map05215,path:map05220,path:map05222,path:map05235,path:map05417 cAMP signaling pathway,Chemokine signaling pathway,NF-kappa B signaling pathway,Apoptosis,Osteoclast differentiation,Toll-like receptor signaling pathway,NOD-like receptor signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Toll and Imd signaling pathway,C-type lectin receptor signaling pathway,IL-17 signaling pathway,Th1 and Th2 cell differentiation,Th17 cell differentiation,T cell receptor signaling pathway,B cell receptor signaling pathway,TNF signaling pathway,Neurotrophin signaling pathway,Adipocytokine signaling pathway,Relaxin signaling pathway,Insulin resistance,Alcoholic liver disease,Epithelial cell signaling in Helicobacter pylori infection,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Legionellosis,Yersinia infection,Leishmaniasis,Chagas disease,Toxoplasmosis,Hepatitis C,Hepatitis B,Measles,Human cytomegalovirus infection,Influenza A,Human T-cell leukemia virus 1 infection,Kaposi sarcoma-associated herpesvirus infection,Herpes simplex virus 1 infection,Epstein-Barr virus infection,Human immunodeficiency virus 1 infection,Coronavirus disease - COVID-19,Pathways in cancer,Viral carcinogenesis,Chemical carcinogenesis - reactive oxygen species,Prostate cancer,Chronic myeloid leukemia,Small cell lung cancer,PD-L1 expression and PD-1 checkpoint pathway in cancer,Lipid and atherosclerosis 350.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K04739 0.0 0.0056980056980056 PRKAR; cAMP-dependent protein kinase regulator path:map04910 Insulin signaling pathway 144.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 3.0 0.0 1.0 0 0 0 0 K04744 0.0 0.3789173789173789 lptD, imp, ostA; LPS-assembly protein 46.0 138.0 136.0 2.0 0.985714285714286 M 0.0 140.0 2.0 0.985714285714286 COG1452 LPS_assembly_outer_membrane_protein_LptD_(organic_solvent_tolerance_protein_OstA) LptD 140.0 0.0 1.0 0.0183705464973262 0.091715978561005 0.0550432625291655 0.0733454320636788 0 0 0 0 K04747 0.0 0.0056980056980056 norF; nitric oxide reductase NorF protein 78.0 2.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 2AJNS 2.0 0.0 1.0 0 0 0 0 K04748 0.1857142857142857 0.1196581196581196 norQ; nitric oxide reductase NorQ protein 106.0 65.0 26.0 5.0 0.481481481481482 S 85.0 50.0 2.0 0.992592592592593 COG0714 MoxR-like_ATPase MoxR 135.0 0.6296296296296297 0.3703703703703703 0.229755756679486 0.953155664244044 0.591455710461765 0.723399907564558 0 0 0 0 K04749 0.02 0.4273504273504273 rsbV; anti-sigma B factor antagonist 16.0 346.0 342.0 3.0 0.985754985754986 T 8.0 343.0 4.0 0.977207977207977 COG1366 Anti-anti-sigma_regulatory_factor_(antagonist_of_anti-sigma_factor) SpoIIAA 351.0 0.0227920227920227 0.9772079772079773 0.0025999000036464 0.0664370478693032 0.0345184739364748 0.0638371478656568 0 0 0 0 K04750 0.0285714285714285 0.2222222222222222 phnB; PhnB protein 54.0 114.0 96.0 4.0 0.844444444444444 S 15.0 120.0 2.0 0.97037037037037 COG2764 Zn-dependent_glyoxalase,_PhnB_family PhnB 135.0 0.1111111111111111 0.8888888888888888 0.0006727937330461 0.0461996913954313 0.0234362425642387 0.0455268976623852 0 0 0 0 K04751 0.2685714285714285 0.5555555555555556 glnB; nitrogen regulatory protein P-II 1 path:map02020 Two-component system 83.0 345.0 217.0 3.0 0.727848101265823 K 165.0 309.0 1.0 1.0 COG0347 Nitrogen_regulatory_protein_PII GlnK 474.0 0.3481012658227848 0.6518987341772152 0.0075057655482514 0.0289293647149706 0.0182175651316109 0.0214235991667192 0 0 0 0 K04752 0.0428571428571428 0.339031339031339 glnK; nitrogen regulatory protein P-II 2 94.0 182.0 173.0 4.0 0.928571428571429 K 16.0 180.0 1.0 1.0 COG0347 Nitrogen_regulatory_protein_PII GlnK 196.0 0.0816326530612244 0.9183673469387756 0.117312721573735 0.360093503022786 0.2387031122982605 0.2427807814490509 0 0 0 0 K04753 0.0085714285714285 0.037037037037037 sufI; suppressor of ftsI 382.0 13.0 9.0 4.0 0.65 Q 4.0 16.0 2.0 0.9 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 20.0 0.2 0.8 0.0054255182173975 0.0117567778272244 0.0085911480223109 0.0063312596098269 0 0 0 0 K04754 0.0 0.2079772079772079 mlaA, vacJ; phospholipid-binding lipoprotein MlaA 133.0 80.0 0.0 1.0 1.0 M 0.0 80.0 1.0 1.0 COG2853 Lipoprotein_subunit_MlaA_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaA 80.0 0.0 1.0 0.0045102968399221 0.0068737818272665 0.0056920393335943 0.0023634849873443 0 0 0 0 K04755 0.02 0.3219373219373219 fdx; ferredoxin, 2Fe-2S 38.0 154.0 152.0 3.0 0.980891719745223 C 7.0 149.0 2.0 0.987261146496815 COG0633 Ferredoxin Fdx 156.0 0.0448717948717948 0.9551282051282052 0.34967694501473 0.0300532451300687 0.1898650950723993 0.3196236998846613 0 0 0 0 K04756 0.0 0.0655270655270655 ahpD; lipoyl-dependent peroxiredoxin subunit D [EC:1.11.1.28] 160.0 15.0 9.0 4.0 0.625 O 0.0 24.0 2.0 0.75 COG2128 Alkylhydroperoxidase_family_enzyme,_contains_CxxC_motif YciW 24.0 0.0 1.0 0.0184178099030101 0.061391810461717 0.0399048101823635 0.0429740005587069 0 0 0 0 K04757 0.0057142857142857 0.3988603988603988 rsbW; serine/threonine-protein kinase RsbW [EC:2.7.11.1] 5.0 253.0 250.0 3.0 0.98443579766537 T 2.0 250.0 6.0 0.949612403100775 COG2172 Anti-sigma_regulatory_factor_(Ser/Thr_protein_kinase) RsbW 252.0 0.0079365079365079 0.992063492063492 0.0036972545333556 0.0162817195076898 0.0099894870205227 0.0125844649743342 0 0 0 0 K04758 0.3142857142857143 0.4957264957264957 feoA; ferrous iron transport protein A 20.0 435.0 426.0 3.0 0.975336322869955 P 180.0 266.0 4.0 0.948430493273543 COG1918 Fe2+_transport_protein_FeoA FeoA 446.0 0.4035874439461883 0.5964125560538116 0.791698859295529 0.646084713958981 0.7188917866272551 0.1456141453365479 1 1 1 1 K04759 0.4342857142857143 0.5612535612535613 feoB; ferrous iron transport protein B 318.0 531.0 530.0 2.0 0.99812030075188 P 252.0 280.0 2.0 0.99812030075188 COG0370 Fe2+_transporter_FeoB FeoB 532.0 0.4736842105263157 0.5263157894736842 0.935693630374937 0.984662862276824 0.9601782463258806 0.0489692319018869 1 1 1 1 K04760 0.0 0.1339031339031339 greB; transcription elongation factor GreB 135.0 47.0 44.0 2.0 0.94 K 0.0 50.0 1.0 1.0 COG0782 Transcription_elongation_factor,_GreA/GreB_family GreA 50.0 0.0 1.0 0.0055467271482333 0.0100815992852511 0.0078141632167422 0.0045348721370178 0 0 0 0 K04761 0.0 0.3076923076923077 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator path:map02026 Biofilm formation - Escherichia coli 199.0 134.0 0.0 1.0 1.0 K 0.0 134.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 134.0 0.0 1.0 0.0016595620658469 0.0904442749601927 0.0460519185130198 0.0887847128943458 0 0 0 0 K04762 0.0 0.2763532763532763 hslR; ribosome-associated heat shock protein Hsp15 89.0 97.0 0.0 1.0 1.0 J 0.0 97.0 1.0 1.0 COG1188 Ribosomal_50S_subunit-recycling_heat_shock_protein,_contains_S4_domain HslR 97.0 0.0 1.0 0.0215061899721432 0.0226021875298759 0.0220541887510095 0.0010959975577326 0 0 0 0 K04763 0.5428571428571428 0.9088319088319088 xerD; integrase/recombinase XerD 5.0 821.0 633.0 5.0 0.792471042471042 L 345.0 641.0 6.0 0.66923818707811 COG4974 Site-specific_recombinase_XerD XerD 986.0 0.3498985801217038 0.6501014198782962 0.200909032082503 0.884163377325569 0.5425362047040361 0.683254345243066 0 0 0 0 K04764 0.0 0.3219373219373219 ihfA, himA; integration host factor subunit alpha 81.0 89.0 45.0 2.0 0.669172932330827 K 0.0 132.0 1.0 1.0 COG0776 Bacterial_nucleoid_DNA-binding_protein_IHF-alpha HimA 132.0 0.0 1.0 0.0015735059770014 0.886176962934547 0.4438752344557742 0.8846034569575455 0 0 0 0 K04765 0.0085714285714285 0.2763532763532763 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9] path:map00230,path:map00240,path:map00760,path:map00770,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Nucleotide metabolism 210.0 68.0 42.0 4.0 0.673267326732673 S 3.0 98.0 1.0 1.0 COG1694 NTP_pyrophosphatase,_house-cleaning_of_non-canonical_NTPs MazG 101.0 0.0297029702970297 0.9702970297029704 0.0469613887857368 0.0192606765818547 0.0331110326837957 0.0277007122038821 0 0 0 0 K04766 0.0057142857142857 0.0484330484330484 acuA; acetoin utilization protein AcuA [EC:2.3.1.-] 115.0 21.0 20.0 2.0 0.954545454545455 K 2.0 20.0 2.0 0.727272727272727 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 22.0 0.0909090909090909 0.9090909090909092 0.0614818228118923 0.0312078171928975 0.0463448200023949 0.0302740056189948 0 0 0 0 K04767 0.0371428571428571 0.2364672364672364 acuB; acetoin utilization protein AcuB 69.0 119.0 107.0 4.0 0.875 S 13.0 130.0 7.0 0.839160839160839 COG0517 CBS_domain CBS 143.0 0.0909090909090909 0.9090909090909092 0.566478046705248 0.630401036278872 0.59843954149206 0.0639229895736239 0 1 0 1 K04768 0.1828571428571428 0.1994301994301994 acuC; acetoin utilization protein AcuC 204.0 158.0 0.0 1.0 1.0 BQ 79.0 79.0 1.0 1.0 COG0123 Acetoin_utilization_deacetylase_AcuC_or_a_related_deacetylase AcuC 158.0 0.5 0.5 0.538730352363223 0.581362685604118 0.5600465189836705 0.0426323332408949 0 1 0 1 K04769 0.0 0.0911680911680911 spoVT; AbrB family transcriptional regulator, stage V sporulation protein T 157.0 30.0 26.0 2.0 0.882352941176471 K 0.0 34.0 2.0 0.882352941176471 COG2002 Bifunctional_DNA-binding_transcriptional_regulator_of_stationary/sporulation/toxin_gene_expression_and_antitoxin_component_of_the_YhaV-PrlF_toxin-antitoxin_module AbrB 34.0 0.0 1.0 0.0019146249549305 0.0140623003784251 0.0079884626666778 0.0121476754234946 0 0 0 0 K04770 0.0028571428571428 0.0883190883190883 lonH; Lon-like ATP-dependent protease [EC:3.4.21.-] 364.0 35.0 0.0 1.0 1.0 O 1.0 34.0 3.0 0.857142857142857 COG1067 Predicted_ATP-dependent_protease LonB 35.0 0.0285714285714285 0.9714285714285714 0.519612010507754 0.0531491813290992 0.2863805959184266 0.4664628291786548 0 0 0 1 K04771 0.0857142857142857 0.7407407407407407 degP, htrA; serine protease Do [EC:3.4.21.107] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 26.0 412.0 252.0 7.0 0.690117252931323 O 32.0 560.0 6.0 0.95644891122278 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 592.0 0.054054054054054 0.945945945945946 0.0112643816608802 0.282082188142353 0.1466732849016165 0.2708178064814728 0 0 0 0 K04772 0.0028571428571428 0.1367521367521367 degQ, hhoA; serine protease DegQ [EC:3.4.21.-] 228.0 45.0 22.0 2.0 0.661764705882353 O 1.0 67.0 1.0 1.0 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 68.0 0.0147058823529411 0.9852941176470588 0.0416996277741895 0.347173897357664 0.1944367625659267 0.3054742695834745 0 0 0 0 K04773 0.4285714285714285 0.6438746438746439 sppA; protease IV [EC:3.4.21.-] 89.0 337.0 197.0 2.0 0.706498951781971 OU 180.0 297.0 1.0 1.0 COG0616 Periplasmic_serine_protease,_ClpP_class SppA 477.0 0.3773584905660377 0.6226415094339622 0.193394897053679 0.573714048131398 0.3835544725925385 0.3803191510777191 0 0 0 0 K04774 0.0 0.1367521367521367 sohB; serine protease SohB [EC:3.4.21.-] 185.0 48.0 0.0 1.0 1.0 OU 0.0 48.0 1.0 1.0 COG0616 Periplasmic_serine_protease,_ClpP_class SppA 48.0 0.0 1.0 0.0097971553545139 0.0174544632889734 0.0136258093217436 0.0076573079344595 0 0 0 0 K04775 0.0 0.0484330484330484 ydgD; protease YdgD [EC:3.4.21.-] 112.0 20.0 19.0 2.0 0.952380952380952 E 0.0 21.0 1.0 1.0 COG3591 V8-like_Glu-specific_endopeptidase eMpr 21.0 0.0 1.0 0.0259522152491721 0.0766966397130417 0.0513244274811069 0.0507444244638696 0 0 0 0 K04780 0.0 0.0398860398860398 dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 382.0 16.0 0.0 1.0 1.0 Q 0.0 16.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 16.0 0.0 1.0 0.0035963699996059 0.0126526330475819 0.0081245015235939 0.009056263047976 0 0 0 0 K04781 0.0 0.0056980056980056 mbtI, irp9, ybtS; salicylate synthetase [EC:5.4.4.2 4.2.99.21] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 413.0 2.0 1.0 2.0 0.666666666666667 EH 0.0 3.0 2.0 0.666666666666667 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 3.0 0.0 1.0 0 0 0 0 K04782 0.0085714285714285 0.0712250712250712 pchB; isochorismate pyruvate lyase [EC:4.2.99.21] path:map01053,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Biosynthesis of secondary metabolites 74.0 25.0 21.0 3.0 0.833333333333333 E 3.0 27.0 2.0 0.833333333333333 COG1605 Chorismate_mutase PheA 30.0 0.1 0.9 0.406003890307585 0.233889012441821 0.319946451374703 0.172114877865764 0 0 0 0 K04783 0.0 0.0056980056980056 irp5, ybtE; yersiniabactin salicyl-AMP ligase [EC:6.3.2.-] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 521.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 2.0 0.0 1.0 0 0 0 0 K04784 0.0 0.0113960113960113 irp2, HMWP2; yersiniabactin nonribosomal peptide synthetase path:map01053 Biosynthesis of siderophore group nonribosomal peptides 490.0 8.0 0.0 1.0 1.0 Q 0.0 8.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 8.0 0.0 1.0 4.33246147653981e-13 0.0054588750833827 0.0027294375419079 0.0054588750829494 0 0 0 0 K04785 0.0 0.0028490028490028 irp3, ybtU; yersiniabactin synthetase, thiazolinyl reductase component path:map01053 Biosynthesis of siderophore group nonribosomal peptides 101.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG4693 Oxidoreductase_(NAD-binding),_involved_in_siderophore_biosynthesis PchG 1.0 0.0 1.0 0 0 0 0 K04786 0.0028571428571428 0.0313390313390313 irp1, HMWP1; yersiniabactin nonribosomal peptide/polyketide synthase path:map01053 Biosynthesis of siderophore group nonribosomal peptides 64.0 14.0 12.0 3.0 0.823529411764706 Q 1.0 16.0 6.0 0.352941176470588 COG0500 SAM-dependent_methyltransferase SmtA 17.0 0.0588235294117647 0.9411764705882352 8.37685162013918e-13 0.0093792214027388 0.0046896107017882 0.0093792214019011 0 0 0 0 K04787 0.0 0.0085470085470085 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 509.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 4.0 0.0 1.0 2.7572141772453e-07 1.35825704086175e-06 8.1698922929314e-07 1.08253562313722e-06 0 0 0 0 K04788 0.0 0.0113960113960113 mbtB; mycobactin phenyloxazoline synthetase path:map01053 Biosynthesis of siderophore group nonribosomal peptides 581.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 2.0 0.75 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 4.0 0.0 1.0 0.003515794663641 0.0260261746696271 0.014770984666634 0.0225103800059861 0 0 0 0 K04789 0.0 0.0028490028490028 mbtE; mycobactin peptide synthetase MbtE path:map01053 Biosynthesis of siderophore group nonribosomal peptides 1801.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K04790 0.0 0.0028490028490028 mbtC; mycobactin polyketide synthetase MbtC path:map01053 Biosynthesis of siderophore group nonribosomal peptides 440.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 1.0 0.0 1.0 0 0 0 0 K04791 0.0 0.0113960113960113 mbtD; mycobactin polyketide synthetase MbtD path:map01053 Biosynthesis of siderophore group nonribosomal peptides 109.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 2.0 0.5 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 4.0 0.0 1.0 0.0149284106294095 0.0466770389627922 0.0308027247961008 0.0317486283333827 0 0 0 0 K04792 0.0 0.0056980056980056 mbtF; mycobactin peptide synthetase MbtF path:map01053 Biosynthesis of siderophore group nonribosomal peptides 140.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K04793 0.0 0.0113960113960113 mbtG; mycobactin lysine-N-oxygenase path:map01053 Biosynthesis of siderophore group nonribosomal peptides 228.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 1.0 1.0 COG3486 Lysine/ornithine_N-monooxygenase IucD 4.0 0.0 1.0 0.0147358526140647 0.047730844435112 0.0312333485245883 0.0329949918210473 0 0 0 0 K04794 0.8457142857142858 0.0085470085470085 PTH2; peptidyl-tRNA hydrolase, PTH2 family [EC:3.1.1.29] 96.0 286.0 264.0 2.0 0.928571428571429 J 305.0 3.0 1.0 1.0 COG1990 Peptidyl-tRNA_hydrolase Pth2 308.0 0.9902597402597404 0.0097402597402597 0.233254271364487 0.632658125624922 0.4329561984947044 0.3994038542604349 0 0 0 0 K04795 0.8657142857142858 0.0 flpA; fibrillarin-like pre-rRNA processing protein 159.0 309.0 0.0 1.0 1.0 J 309.0 0.0 1.0 1.0 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 309.0 1.0 0.0 0.837686825643393 0.21697706688637 0.5273319462648816 0.6207097587570231 0 0 1 1 K04796 0.8771428571428571 0.0 RUXX; small nuclear ribonucleoprotein 45.0 368.0 307.0 2.0 0.857808857808858 K 429.0 0.0 1.0 1.0 COG1958 Small_nuclear_ribonucleoprotein_(snRNP)_homolog LSM1 429.0 1.0 0.0 0.0710321624552247 0.166549495068512 0.1187908287618683 0.0955173326132872 0 0 0 0 K04797 0.6828571428571428 0.0028490028490028 pfdA, PFDN5; prefoldin alpha subunit 60.0 243.0 0.0 1.0 1.0 O 242.0 1.0 1.0 1.0 COG1730 Prefoldin_subunit_5 GIM5 243.0 0.9958847736625516 0.0041152263374485 0.0216545100660466 0.055193181092888 0.0384238455794673 0.0335386710268413 0 0 0 0 K04798 0.7771428571428571 0.0 pfdB, PFDN6; prefoldin beta subunit 101.0 274.0 0.0 1.0 1.0 O 274.0 0.0 1.0 1.0 COG1382 Prefoldin,_chaperonin_cofactor GimC 274.0 1.0 0.0 0.743838927781166 0.812829752624407 0.7783343402027865 0.068990824843241 0 0 0 1 K04799 0.9371428571428572 0.0028490028490028 FEN1, RAD2; flap endonuclease-1 [EC:3.1.-.-] path:map03030,path:map03410,path:map03450 DNA replication,Base excision repair,Non-homologous end-joining 269.0 345.0 0.0 1.0 1.0 L 344.0 1.0 1.0 1.0 COG0258 5'-3'_exonuclease_Xni/ExoIX_(flap_endonuclease) ExoIX 345.0 0.9971014492753624 0.0028985507246376 0.846055384078383 0.332168313294135 0.589111848686259 0.513887070784248 0 0 1 1 K04800 0.9228571428571428 0.0 rfcL; replication factor C large subunit path:map03030 DNA replication 196.0 327.0 0.0 1.0 1.0 L 327.0 0.0 1.0 1.0 COG0470 DNA_polymerase_III,_delta_prime_subunit HolB 327.0 1.0 0.0 0.885086936396782 0.896506896487643 0.8907969164422125 0.0114199600908609 0 0 1 1 K04801 0.9171428571428571 0.0 rfcS; replication factor C small subunit path:map03030 DNA replication 202.0 435.0 425.0 3.0 0.966666666666667 L 450.0 0.0 5.0 0.96 COG0470 DNA_polymerase_III,_delta_prime_subunit HolB 450.0 1.0 0.0 0.452234909286974 0.580061007233326 0.51614795826015 0.1278260979463519 0 0 0 0 K04802 0.9142857142857144 0.0 PCNA; proliferating cell nuclear antigen path:map03030,path:map03410,path:map03420,path:map03430,path:map04110,path:map04530,path:map05161 DNA replication,Base excision repair,Nucleotide excision repair,Mismatch repair,Cell cycle,Tight junction,Hepatitis B 130.0 413.0 0.0 1.0 1.0 L 413.0 0.0 1.0 1.0 COG0592 DNA_polymerase_III_sliding_clamp_(beta)_subunit,_PCNA_homolog DnaN 413.0 1.0 0.0 0.861225749018535 0.947954287068677 0.904590018043606 0.086728538050142 0 0 1 1 K04835 0.0428571428571428 0.0341880341880341 mal; methylaspartate ammonia-lyase [EC:4.3.1.2] path:map00630,path:map00660,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 408.0 29.0 28.0 2.0 0.966666666666667 E 18.0 12.0 1.0 1.0 COG3799 Methylaspartate_ammonia-lyase Mal 30.0 0.6 0.4 0.0484569069976649 0.26568906585274 0.1570729864252024 0.217232158855075 0 0 0 0 K04844 0.0 0.0113960113960113 245.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG1554 Kojibiose_phosphorylase_YcjT ATH1 4.0 0.0 1.0 0.127875500269319 0.243822247716434 0.1858488739928764 0.115946747447115 0 0 0 0 K04860 0.0028571428571428 0.0 CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3 path:map04010,path:map04260,path:map04261,path:map04921,path:map05410,path:map05412,path:map05414 MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Oxytocin signaling pathway,Hypertrophic cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy,Dilated cardiomyopathy 595.0 1.0 0.0 1.0 1.0 PT 1.0 0.0 1.0 1.0 KOG2353 1.0 1.0 0.0 0 0 0 0 K04940 0.0485714285714285 0.0968660968660968 odh; opine dehydrogenase [EC:1.5.1.28] 214.0 45.0 39.0 6.0 0.737704918032787 C 17.0 44.0 5.0 0.80327868852459 COG0240 Glycerol-3-phosphate_dehydrogenase GpsA 61.0 0.2786885245901639 0.7213114754098361 0.305246492271622 0.314529649204178 0.3098880707379 0.0092831569325559 0 0 0 0 K05020 0.0542857142857142 0.1339031339031339 opuD, betL; glycine betaine transporter 405.0 81.0 69.0 3.0 0.826530612244898 M 27.0 71.0 2.0 0.989795918367347 COG1292 Choline-glycine_betaine_transporter BetT 98.0 0.2755102040816326 0.7244897959183674 0.0049940198939751 0.416606147914883 0.210800083904429 0.4116121280209079 0 0 0 0 K05027 0.0028571428571428 0.0 CLCA1; calcium-activated chloride channel regulator 1 path:map04924,path:map04972 Renin secretion,Pancreatic secretion 710.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 28JCE 1.0 1.0 0.0 0 0 0 0 K05030 0.0028571428571428 0.0 CLCA3_4; calcium-activated chloride channel regulator 3/4 path:map04924,path:map04972 Renin secretion,Pancreatic secretion 710.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 28JCE 1.0 1.0 0.0 0 0 0 0 K05088 0.0028571428571428 0.0 ROS1; proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1] path:map04013 MAPK signaling pathway - fly 91.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 KOG3360 1.0 1.0 0.0 0 0 0 0 K05245 0.0 0.0113960113960113 caiT; L-carnitine/gamma-butyrobetaine antiporter 503.0 2.0 0.0 3.0 0.4 M 0.0 5.0 1.0 1.0 COG1292 Choline-glycine_betaine_transporter BetT 5.0 0.0 1.0 5.91755879036515e-12 0.0739406433677329 0.0369703216868252 0.0739406433618153 0 0 0 0 K05275 0.0885714285714285 0.1766381766381766 E1.1.1.65; pyridoxine 4-dehydrogenase [EC:1.1.1.65] path:map00750,path:map01100,path:map01120 Vitamin B6 metabolism,Metabolic pathways,Microbial metabolism in diverse environments 220.0 120.0 89.0 2.0 0.794701986754967 C 32.0 119.0 3.0 0.788079470198676 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 151.0 0.2119205298013245 0.7880794701986755 0.0154422821219173 0.372317981005417 0.1938801315636671 0.3568756988834997 0 0 0 0 K05281 0.0057142857142857 0.0284900284900284 IFR; 2'-hydroxyisoflavone reductase [EC:1.3.1.45] path:map00943,path:map01100,path:map01110 Isoflavonoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 311.0 16.0 0.0 1.0 1.0 GM 2.0 14.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 16.0 0.125 0.875 0.0918657239434239 0.285819948500064 0.1888428362217439 0.19395422455664 0 0 0 0 K05285 0.0028571428571428 0.0 PIGN; GPI ethanolamine phosphate transferase 1 [EC:2.7.-.-] path:map00563,path:map01100 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,Metabolic pathways 830.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG1524 c-di-AMP_phosphodiesterase_AtaC_or_nucleotide_pyrophosphatase,_AlkP_superfamily AtaC 1.0 1.0 0.0 0 0 0 0 K05286 0.0057142857142857 0.0056980056980056 PIGB; GPI mannosyltransferase 3 [EC:2.4.1.-] path:map00563,path:map01100 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,Metabolic pathways 368.0 5.0 3.0 2.0 0.714285714285714 M 2.0 5.0 3.0 0.714285714285714 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 7.0 0.2857142857142857 0.7142857142857143 0.0727868285245227 0.353867284016684 0.2133270562706033 0.2810804554921613 0 0 0 0 K05296 0.0 0.0085470085470085 E1.1.1.51; 3(or 17)beta-hydroxysteroid dehydrogenase [EC:1.1.1.51] path:map00140,path:map00984,path:map01100,path:map01120 Steroid hormone biosynthesis,Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 228.0 3.0 0.0 1.0 1.0 IQ 0.0 3.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 3.0 0.0 1.0 0 0 0 0 K05297 0.0142857142857142 0.0598290598290598 rubB, alkT; rubredoxin---NAD+ reductase [EC:1.18.1.1] path:map00071 Fatty acid degradation 12.0 24.0 19.0 2.0 0.827586206896552 C 5.0 24.0 3.0 0.344827586206897 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 29.0 0.1724137931034483 0.8275862068965517 0.0139317755110945 0.0290130109978284 0.0214723932544614 0.0150812354867338 0 0 0 0 K05299 0.0 0.0 fdhA; formate dehydrogenase (NADP+) alpha subunit [EC:1.17.1.10] path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 91.0 0.0 1.0 1.0 C 0.0 0.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 0.0 0 0 0 0 K05301 0.0 0.0199430199430199 sorA; sulfite dehydrogenase (cytochrome) subunit A [EC:1.8.2.1] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 86.0 5.0 1.0 2.0 0.555555555555556 S 0.0 9.0 4.0 0.333333333333333 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 9.0 0.0 1.0 0.0305909746965082 0.0783998409732076 0.0544954078348579 0.0478088662766994 0 0 0 0 K05303 0.0142857142857142 0.0854700854700854 K05303; O-methyltransferase [EC:2.1.1.-] 93.0 16.0 7.0 6.0 0.41025641025641 S 5.0 34.0 2.0 0.974358974358975 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 39.0 0.1282051282051282 0.8717948717948718 0.0840156970990838 0.121912559003655 0.1029641280513694 0.0378968619045712 0 0 0 0 K05304 0.0085714285714285 0.0142450142450142 NANS, SAS; sialic acid synthase [EC:2.5.1.56 2.5.1.57 2.5.1.132] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 222.0 8.0 0.0 1.0 1.0 M 3.0 5.0 2.0 0.875 COG2089 Sialic_acid_synthase_SpsE,_contains_C-terminal_SAF_domain SpsE 8.0 0.375 0.625 0.0944857990612033 0.181992732942616 0.1382392660019096 0.0875069338814127 0 0 0 0 K05305 0.0 0.017094017094017 FUK; fucokinase [EC:2.7.1.52] path:map00051,path:map00520,path:map01100,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 352.0 3.0 0.0 2.0 0.5 JM 0.0 6.0 2.0 0.666666666666667 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 6.0 0.0 1.0 0.236647331549426 0.329973173876324 0.283310252712875 0.093325842326898 0 0 0 0 K05306 0.0085714285714285 0.0683760683760683 phnX; phosphonoacetaldehyde hydrolase [EC:3.11.1.1] path:map00440,path:map01100,path:map01120 Phosphonate and phosphinate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 211.0 25.0 19.0 2.0 0.806451612903226 S 3.0 26.0 2.0 0.806451612903226 COG0637 Beta-phosphoglucomutase,_HAD_superfamily YcjU 29.0 0.1034482758620689 0.896551724137931 0.027895974430133 0.0671761112210601 0.0475360428255965 0.039280136790927 0 0 0 0 K05307 0.0 0.0028490028490028 THTPA; thiamine-triphosphatase [EC:3.6.1.28] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 195.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DAPC 1.0 0.0 1.0 0 0 0 0 K05308 0.1571428571428571 0.0 gnaD; gluconate/galactonate dehydratase [EC:4.2.1.140] path:map00030,path:map00052,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 359.0 71.0 0.0 1.0 1.0 M 71.0 0.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 71.0 1.0 0.0 0.0016583856214034 0.0031098274903751 0.0023841065558892 0.0014514418689716 0 0 0 0 K05309 0.02 0.0 PTGES2; microsomal prostaglandin-E synthase 2 [EC:5.3.99.3] path:map00590,path:map01100 Arachidonic acid metabolism,Metabolic pathways 206.0 7.0 0.0 1.0 1.0 O 7.0 0.0 1.0 1.0 KOG3029 7.0 1.0 0.0 6.83754112541666e-06 0.0029486630463836 0.0014777502937545 0.0029418255052581 0 0 0 0 K05311 0.0 0.0769230769230769 cggR; central glycolytic genes regulator 316.0 27.0 0.0 1.0 1.0 K 0.0 27.0 1.0 1.0 COG2390 DNA-binding_transcriptional_regulator_LsrR,_DeoR_family DeoR 27.0 0.0 1.0 0.0013019826488438 0.0071481156252696 0.0042250491370567 0.0058461329764258 0 0 0 0 K05337 0.4828571428571429 0.3532763532763532 fer; ferredoxin 11.0 438.0 437.0 2.0 0.997722095671982 C 237.0 201.0 3.0 0.927107061503417 COG1141 Ferredoxin Fer 438.0 0.541095890410959 0.4589041095890411 0.255806032454781 0.648340537795616 0.4520732851251985 0.3925345053408349 0 0 0 0 K05338 0.0 0.017094017094017 lrgA; holin-like protein path:map02020 Two-component system 110.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG1380 Putative_effector_of_murein_hydrolase_LrgA,_UPF0299_family YohJ 6.0 0.0 1.0 0.0225011236102317 0.0575547893913765 0.0400279565008041 0.0350536657811448 0 0 0 0 K05339 0.0 0.0085470085470085 lrgB; holin-like protein LrgB path:map02020 Two-component system 226.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1346 Putative_effector_of_murein_hydrolase LrgB 3.0 0.0 1.0 0 0 0 0 K05340 0.0085714285714285 0.0284900284900284 glcU; glucose uptake protein 256.0 11.0 8.0 2.0 0.785714285714286 G 3.0 11.0 1.0 1.0 COG4975 Glucose_uptake_protein_GlcU GlcU 14.0 0.2142857142857142 0.7857142857142857 0.101946935716476 0.495666291475031 0.2988066135957535 0.393719355758555 0 0 0 0 K05341 0.0057142857142857 0.1168091168091168 E2.4.1.4; amylosucrase [EC:2.4.1.4] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 398.0 46.0 0.0 1.0 1.0 G 2.0 44.0 2.0 0.934782608695652 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 46.0 0.0434782608695652 0.9565217391304348 0.0304530004392436 0.623279812996596 0.3268664067179198 0.5928268125573524 0 0 0 0 K05342 0.0057142857142857 0.0997150997150997 treP; alpha,alpha-trehalose phosphorylase [EC:2.4.1.64] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 634.0 37.0 33.0 2.0 0.902439024390244 G 2.0 38.0 2.0 0.804878048780488 COG1554 Kojibiose_phosphorylase_YcjT ATH1 40.0 0.05 0.95 0.154056916142077 0.573747617677098 0.3639022669095875 0.419690701535021 0 0 0 0 K05343 0.1 0.2621082621082621 treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 241.0 172.0 0.0 1.0 1.0 G 41.0 131.0 2.0 0.895348837209302 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 172.0 0.2383720930232558 0.7616279069767442 0.0220303809430867 0.272996096243238 0.1475132385931623 0.2509657153001513 0 0 0 0 K05346 0.0 0.0484330484330484 deoR; deoxyribonucleoside regulator 258.0 25.0 0.0 1.0 1.0 K 0.0 25.0 1.0 1.0 COG2390 DNA-binding_transcriptional_regulator_LsrR,_DeoR_family DeoR 25.0 0.0 1.0 0.0152966704122571 0.0195479865085943 0.0174223284604257 0.0042513160963371 0 0 0 0 K05349 0.1228571428571428 0.3846153846153846 bglX; beta-glucosidase [EC:3.2.1.21] path:map00460,path:map00500,path:map00999,path:map01100,path:map01110 Cyanoamino acid metabolism,Starch and sucrose metabolism,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 208.0 405.0 401.0 7.0 0.975903614457831 G 82.0 333.0 10.0 0.968674698795181 COG1472 Periplasmic_beta-glucosidase_and_related_glycosidases BglX 415.0 0.1975903614457831 0.8024096385542169 0.106479869004078 0.344783876429271 0.2256318727166745 0.2383040074251929 0 0 0 0 K05350 0.0828571428571428 0.3247863247863248 bglB; beta-glucosidase [EC:3.2.1.21] path:map00460,path:map00500,path:map00999,path:map01100,path:map01110 Cyanoamino acid metabolism,Starch and sucrose metabolism,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 173.0 241.0 240.0 3.0 0.991769547325103 G 33.0 209.0 4.0 0.983539094650206 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase BglB 242.0 0.1363636363636363 0.8636363636363636 0.372087961913727 0.707451414696061 0.539769688304894 0.335363452782334 0 0 0 0 K05351 0.0 0.037037037037037 E1.1.1.9; D-xylulose reductase [EC:1.1.1.9] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 335.0 12.0 9.0 2.0 0.8 E 0.0 15.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 15.0 0.0 1.0 0.0201194125918944 0.0550859393180142 0.0376026759549543 0.0349665267261198 0 0 0 0 K05352 0.0057142857142857 0.0056980056980056 tarJ; ribitol-5-phosphate 2-dehydrogenase (NADP+) [EC:1.1.1.405] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 334.0 3.0 1.0 2.0 0.6 E 2.0 3.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 5.0 0.4 0.6 0.0009009911840167 1.24766173464518e-08 0.000450501830317 0.0009009787073993 0 0 0 0 K05356 0.0 0.0484330484330484 SPS, sds; all-trans-nonaprenyl-diphosphate synthase [EC:2.5.1.84 2.5.1.85] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 319.0 17.0 0.0 1.0 1.0 H 0.0 17.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 17.0 0.0 1.0 0.0002499044249194 0.0004984133944894 0.0003741589097044 0.0002485089695699 0 0 0 0 K05357 0.02 0.0 VKORC1; vitamin-K-epoxide reductase (warfarin-sensitive) [EC:1.17.4.4] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 128.0 7.0 0.0 1.0 1.0 S 7.0 0.0 1.0 1.0 2CUJS 7.0 1.0 0.0 0.0013113426419093 0.0134905507991834 0.0074009467205463 0.0121792081572741 0 0 0 0 K05358 0.0 0.0056980056980056 quiA; quinate dehydrogenase (quinone) [EC:1.1.5.8] path:map00400,path:map01100,path:map01110 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 766.0 3.0 2.0 2.0 0.75 G 0.0 4.0 1.0 1.0 COG4993 Glucose_dehydrogenase,_PQQ-dependent Gcd 4.0 0.0 1.0 5.58223984717743e-12 1.03277215192733e-11 7.954980683225365e-12 4.74548167209587e-12 0 0 0 0 K05362 0.0 0.0227920227920227 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 300.0 9.0 0.0 1.0 1.0 M 0.0 9.0 1.0 1.0 COG0769 UDP-N-acetylmuramyl_tripeptide_synthase MurE 9.0 0.0 1.0 0.0102828629637174 0.0192941777670202 0.0147885203653688 0.0090113148033028 0 0 0 0 K05363 0.0085714285714285 0.0997150997150997 murM; serine/alanine adding enzyme [EC:2.3.2.10] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 175.0 41.0 0.0 1.0 1.0 V 4.0 37.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 41.0 0.0975609756097561 0.902439024390244 0.0406737235392998 0.991388200850833 0.5160309621950664 0.9507144773115332 0 0 0 0 K05364 0.0 0.1538461538461538 pbpA; penicillin-binding protein A path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 303.0 54.0 53.0 4.0 0.947368421052632 M 0.0 57.0 2.0 0.982456140350877 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 57.0 0.0 1.0 0.0047359547470698 0.487381988999539 0.2460589718733044 0.4826460342524692 0 0 0 0 K05365 0.0 0.1994301994301994 mrcB; penicillin-binding protein 1B [EC:2.4.1.129 3.4.16.4] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 265.0 70.0 58.0 2.0 0.853658536585366 M 0.0 82.0 2.0 0.853658536585366 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 82.0 0.0 1.0 0.847039231499024 0.986817625634872 0.916928428566948 0.1397783941358479 0 0 1 1 K05366 0.0 0.7065527065527065 mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 204.0 378.0 376.0 3.0 0.992125984251968 M 0.0 381.0 4.0 0.532808398950131 COG5009 Membrane_carboxypeptidase/penicillin-binding_protein MrcA 381.0 0.0 1.0 0.666586883053987 0.757266770270661 0.711926826662324 0.090679887216674 0 0 0 1 K05367 0.0 0.1965811965811965 pbpC; penicillin-binding protein 1C [EC:2.4.1.129] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 436.0 72.0 0.0 1.0 1.0 M 0.0 72.0 2.0 0.972222222222222 COG4953 Membrane_carboxypeptidase/penicillin-binding_protein_PbpC PbpC 72.0 0.0 1.0 0.0128754543049037 0.0977456140353597 0.0553105341701316 0.084870159730456 0 0 0 0 K05368 0.0 0.0256410256410256 fre, ubiB; NAD(P)H-flavin reductase [EC:1.5.1.41] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 191.0 8.0 7.0 2.0 0.888888888888889 C 0.0 9.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 9.0 0.0 1.0 0.0293108951654635 0.131484101692552 0.0803974984290077 0.1021732065270885 0 0 0 0 K05369 0.0 0.017094017094017 pebA; 15,16-dihydrobiliverdin:ferredoxin oxidoreductase [EC:1.3.7.2] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 231.0 5.0 4.0 4.0 0.625 C 0.0 8.0 1.0 1.0 28II3 8.0 0.0 1.0 0.0102859553881249 0.0117374606094408 0.0110117079987828 0.0014515052213159 0 0 0 0 K05370 0.0 0.0142450142450142 pebB; phycoerythrobilin:ferredoxin oxidoreductase [EC:1.3.7.3] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 244.0 2.0 1.0 4.0 0.4 C 0.0 5.0 1.0 1.0 28HFN 5.0 0.0 1.0 0.0005008147119763 0.0027040304992417 0.001602422605609 0.0022032157872654 0 0 0 0 K05371 0.0 0.0398860398860398 pcyA; phycocyanobilin:ferredoxin oxidoreductase [EC:1.3.7.5] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 240.0 8.0 4.0 3.0 0.533333333333333 C 0.0 15.0 1.0 1.0 28HFN 15.0 0.0 1.0 1.97908417370028e-06 5.69876664347166e-06 3.83892540858597e-06 3.71968246977138e-06 0 0 0 0 K05372 0.0 0.0142450142450142 ybtA; AraC family transcriptional regulator 233.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 5.0 0.0 1.0 0.064644400182833 0.143239759772466 0.1039420799776495 0.078595359589633 0 0 0 0 K05373 0.0 0.0056980056980056 ybtX, irp8; MFS transporter, putative signal transducer 67.0 1.0 0.0 2.0 0.5 EGP 0.0 2.0 2.0 0.5 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 2.0 0.0 1.0 0 0 0 0 K05374 0.0 0.0028490028490028 irp4, ybtT; yersiniabactin synthetase, thioesterase component 186.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3208 Surfactin_synthase_thioesterase_subunit GrsT 1.0 0.0 1.0 0 0 0 0 K05375 0.0 0.074074074074074 mbtH, nocI; MbtH protein path:map00261,path:map01100,path:map01110 Monobactam biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 63.0 37.0 30.0 2.0 0.840909090909091 S 0.0 44.0 1.0 1.0 COG3251 MbtH_family_protein,_regulates_adenylation_domains_of_NRPSs MbtH 44.0 0.0 1.0 0.0048875792344988 0.010819305789323 0.0078534425119109 0.0059317265548242 0 0 0 0 K05376 0.0 0.0113960113960113 cpeA, mpeA; phycoerythrin alpha chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 95.0 7.0 6.0 3.0 0.777777777777778 C 0.0 9.0 2.0 0.888888888888889 28I84 9.0 0.0 1.0 0.0001864448856586 0.0021337939521576 0.001160119418908 0.0019473490664989 0 0 0 0 K05377 0.0 0.017094017094017 cpeB, mpeB; phycoerythrin beta chain path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 177.0 10.0 0.0 1.0 1.0 C 0.0 10.0 3.0 0.7 28MBA 10.0 0.0 1.0 0.0046521495154604 0.0110635191885757 0.007857834352018 0.0064113696731153 0 0 0 0 K05378 0.0 0.0199430199430199 cpeC, mpeC; phycoerythrin-associated linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 161.0 15.0 14.0 2.0 0.9375 H 0.0 16.0 2.0 0.9375 COG0237 Dephospho-CoA_kinase CoaE 16.0 0.0 1.0 0.0097284047293738 0.0296262198951296 0.0196773123122517 0.0198978151657558 0 0 0 0 K05379 0.0 0.0113960113960113 cpeD, mpeD; phycoerythrin-associated linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 149.0 4.0 0.0 1.0 1.0 H 0.0 4.0 1.0 1.0 COG0237 Dephospho-CoA_kinase CoaE 4.0 0.0 1.0 0.128223886138462 0.266471526551219 0.1973477063448405 0.1382476404127569 0 0 0 0 K05380 0.0 0.017094017094017 cpeE; phycoerythrin-associated linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 173.0 9.0 0.0 1.0 1.0 H 0.0 9.0 1.0 1.0 COG0237 Dephospho-CoA_kinase CoaE 9.0 0.0 1.0 0.0278498627690827 0.0790131563332084 0.0534315095511455 0.0511632935641257 0 0 0 0 K05381 0.0 0.0113960113960113 cpeR; phycoerythrin-associated linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 101.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2AGD5 4.0 0.0 1.0 0.0112254398359099 0.0060941385741389 0.0086597892050244 0.005131301261771 0 0 0 0 K05382 0.0 0.0341880341880341 cpeS; phycoerythrin-associated linker protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 171.0 11.0 9.0 2.0 0.846153846153846 E 0.0 13.0 1.0 1.0 28IBS 13.0 0.0 1.0 0.0017845870208627 0.0013295992466793 0.001557093133771 0.0004549877741834 0 0 0 0 K05383 0.0 0.037037037037037 cpeT; CpeT protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 192.0 16.0 14.0 2.0 0.888888888888889 E 0.0 18.0 1.0 1.0 2CCNY 18.0 0.0 1.0 0.0001365885768301 0.0012388405080588 0.0006877145424444 0.0011022519312287 0 0 0 0 K05384 0.0 0.0284900284900284 cpeU, mpeU; bilin biosynthesis protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 108.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 COG1413 HEAT_repeat HEAT 14.0 0.0 1.0 0.0356293046367764 0.291753486501614 0.1636913955691951 0.2561241818648376 0 0 0 0 K05385 0.0 0.0569800569800569 cpeY; bilin biosynthesis protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 72.0 22.0 20.0 2.0 0.916666666666667 C 0.0 24.0 3.0 0.916666666666667 COG1413 HEAT_repeat HEAT 24.0 0.0 1.0 0.0312377629794535 0.0662640539043662 0.0487509084419098 0.0350262909249127 0 0 0 0 K05386 0.0 0.0427350427350427 cpeZ; bilin biosynthesis protein path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 111.0 21.0 20.0 2.0 0.954545454545455 C 0.0 22.0 1.0 1.0 COG1413 HEAT_repeat HEAT 22.0 0.0 1.0 0.0214549274596285 0.0280737750602293 0.0247643512599289 0.0066188476006007 0 0 0 0 K05389 0.0028571428571428 0.0 KCNKF; potassium channel subfamily K, other eukaryote 151.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG1418 1.0 1.0 0.0 0 0 0 0 K05396 0.0314285714285714 0.1737891737891738 dcyD; D-cysteine desulfhydrase [EC:4.4.1.15] path:map00270,path:map00470,path:map01100 Cysteine and methionine metabolism,D-Amino acid metabolism,Metabolic pathways 193.0 88.0 87.0 2.0 0.98876404494382 E 11.0 78.0 1.0 1.0 COG2515 1-aminocyclopropane-1-carboxylate_deaminase/D-cysteine_desulfhydrase,_PLP-dependent_ACC_family Acd 89.0 0.1235955056179775 0.8764044943820225 0.278631082634727 0.767287833524824 0.5229594580797755 0.4886567508900969 0 0 0 0 K05499 0.0 0.1737891737891738 cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG 161.0 99.0 0.0 1.0 1.0 K 0.0 99.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 99.0 0.0 1.0 0.0154361836799711 0.108340659613109 0.06188842164654 0.0929044759331379 0 0 0 0 K05501 0.0 0.0427350427350427 slmA, ttk; TetR/AcrR family transcriptional regulator 191.0 9.0 3.0 2.0 0.6 D 0.0 15.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 15.0 0.0 1.0 3.6743929916395006e-10 6.64239408673015e-08 3.3395690083232724e-08 6.605650156813755e-08 0 0 0 0 K05515 0.0 0.792022792022792 mrdA; penicillin-binding protein 2 [EC:3.4.16.4] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 170.0 312.0 310.0 3.0 0.987341772151899 M 0.0 317.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 317.0 0.0 1.0 0.458419274394128 0.945510698552643 0.7019649864733855 0.487091424158515 0 0 0 0 K05516 0.1857142857142857 0.5555555555555556 cbpA; curved DNA-binding protein 110.0 328.0 327.0 2.0 0.996960486322188 O 73.0 256.0 4.0 0.978723404255319 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 329.0 0.2218844984802431 0.7781155015197568 0.306312062622384 0.93567852281674 0.620995292719562 0.629366460194356 0 0 0 0 K05517 0.0 0.0085470085470085 tsx; nucleoside-specific channel-forming protein 263.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3248 Nucleoside-specific_outer_membrane_channel_protein_Tsx Tsx 4.0 0.0 1.0 2.46438906691128e-12 4.1854774433846996e-12 3.32493325514799e-12 1.7210883764734205e-12 0 0 0 0 K05518 0.0028571428571428 0.0227920227920227 rsbX; phosphoserine phosphatase RsbX [EC:3.1.3.3] 176.0 8.0 7.0 2.0 0.888888888888889 KT 1.0 8.0 2.0 0.888888888888889 COG2208 Phosphoserine_phosphatase_RsbU,_regulator_of_sigma_subunit RsbU 9.0 0.1111111111111111 0.8888888888888888 0.0093032327205489 0.0176780996105608 0.0134906661655548 0.0083748668900119 0 0 0 0 K05519 0.0 0.0256410256410256 med; transcriptional activator of comK gene 303.0 5.0 0.0 2.0 0.5 S 0.0 10.0 1.0 1.0 COG1744 Lipoprotein_Med,_regulator_of_KinD/Spo0A,_PBP1-ABC_superfamily,_includes_NupN Med 10.0 0.0 1.0 0.0074612787701971 0.0434100798743304 0.0254356793222637 0.0359488011041332 0 0 0 0 K05520 0.4228571428571429 0.4871794871794871 pfpI; protease I [EC:3.5.1.124] 80.0 354.0 305.0 4.0 0.850961538461538 S 184.0 232.0 1.0 1.0 COG0693 Protein/nucleotide_deglycase,_PfpI/YajL/DJ-1_family_(repair_of_methylglyoxal-glycated_proteins_and_nucleic_acids) YajL 416.0 0.4423076923076923 0.5576923076923077 0.128920093070098 0.226609005796258 0.177764549433178 0.09768891272616 0 0 0 0 K05521 0.0571428571428571 0.1225071225071225 draG; ADP-ribosyl-[dinitrogen reductase] hydrolase [EC:3.2.2.24] 163.0 62.0 58.0 4.0 0.873239436619718 O 24.0 47.0 6.0 0.873239436619718 COG1397 ADP-ribosylglycohydrolase DraG 71.0 0.3380281690140845 0.6619718309859155 0.0463925611251427 0.4617690003562 0.2540807807406713 0.4153764392310572 0 0 0 0 K05522 0.0314285714285714 0.1082621082621082 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18] path:map03410 Base excision repair 161.0 70.0 0.0 1.0 1.0 L 12.0 58.0 1.0 1.0 COG0266 Formamidopyrimidine-DNA_glycosylase Nei 70.0 0.1714285714285714 0.8285714285714286 0.0089021837373359 0.0768172420643524 0.0428597129008441 0.0679150583270165 0 0 0 0 K05523 0.0 0.017094017094017 hchA; D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124] path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 278.0 5.0 4.0 2.0 0.833333333333333 S 0.0 6.0 1.0 1.0 COG0693 Protein/nucleotide_deglycase,_PfpI/YajL/DJ-1_family_(repair_of_methylglyoxal-glycated_proteins_and_nucleic_acids) YajL 6.0 0.0 1.0 0.0536709287358111 0.121457175193242 0.0875640519645265 0.0677862464574309 0 0 0 0 K05524 0.0371428571428571 0.2962962962962963 fdxA; ferredoxin 78.0 131.0 130.0 2.0 0.992424242424242 C 13.0 119.0 4.0 0.954545454545455 COG1146 NAD-dependent_dihydropyrimidine_dehydrogenase,_PreA_subunit PreA 132.0 0.0984848484848484 0.9015151515151516 0.0293894315894985 0.217762661781935 0.1235760466857167 0.1883732301924365 0 0 0 0 K05525 0.0 0.0028490028490028 linC, CYP111A; linalool 8-monooxygenase [EC:1.14.14.84] path:map00902,path:map01110 Monoterpenoid biosynthesis,Biosynthesis of secondary metabolites 387.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K05526 0.0 0.0398860398860398 astE; succinylglutamate desuccinylase [EC:3.5.1.96] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 250.0 14.0 0.0 1.0 1.0 E 0.0 14.0 1.0 1.0 COG2988 Succinylglutamate_desuccinylase AstE 14.0 0.0 1.0 0.0181575945612915 0.0503008356357861 0.0342292150985387 0.0321432410744946 0 0 0 0 K05527 0.0 0.1766381766381766 bolA; BolA family transcriptional regulator, general stress-responsive regulator 64.0 62.0 56.0 3.0 0.885714285714286 T 0.0 70.0 2.0 0.885714285714286 COG0271 DNA-binding_global_transcriptional_regulator_BolA,_affects_cell_shape,_cell_division_and_biofilm_formation BolA 70.0 0.0 1.0 0.0022002296178075 0.0042841269013982 0.0032421782596028 0.0020838972835907 0 0 0 0 K05539 0.0 0.2022792022792023 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-] 274.0 61.0 51.0 2.0 0.859154929577465 J 0.0 71.0 1.0 1.0 COG0042 tRNA-dihydrouridine_synthase DusA 71.0 0.0 1.0 0.021173199898285 0.0391447847182044 0.0301589923082447 0.0179715848199194 0 0 0 0 K05540 0.1142857142857142 0.4586894586894587 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-] 163.0 139.0 66.0 2.0 0.655660377358491 J 46.0 166.0 1.0 1.0 COG0042 tRNA-dihydrouridine_synthase DusA 212.0 0.2169811320754717 0.7830188679245284 0.0123817471792565 0.661631904996952 0.3370068260881043 0.6492501578176955 0 0 0 0 K05541 0.0 0.0826210826210826 dusC; tRNA-dihydrouridine synthase C [EC:1.-.-.-] 257.0 25.0 21.0 2.0 0.862068965517241 J 0.0 29.0 1.0 1.0 COG0042 tRNA-dihydrouridine_synthase DusA 29.0 0.0 1.0 0.0985467867829149 0.20916472603872 0.1538557564108174 0.1106179392558051 0 0 0 0 K05542 0.0 0.0028490028490028 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88] 338.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0042 tRNA-dihydrouridine_synthase DusA 1.0 0.0 1.0 0 0 0 0 K05548 0.0 0.0569800569800569 benK; MFS transporter, AAHS family, benzoate transport protein 336.0 28.0 26.0 4.0 0.875 EGP 0.0 32.0 2.0 0.9375 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 32.0 0.0 1.0 0 0 0 0 K05549 0.0 0.0427350427350427 benA-xylX; benzoate/toluate 1,2-dioxygenase subunit alpha [EC:1.14.12.10 1.14.12.-] path:map00362,path:map00364,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Fluorobenzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 431.0 14.0 12.0 2.0 0.875 P 0.0 16.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 16.0 0.0 1.0 0.0706200767308777 0.14142777426453 0.1060239254977038 0.0708076975336522 0 0 0 0 K05550 0.0 0.037037037037037 benB-xylY; benzoate/toluate 1,2-dioxygenase subunit beta [EC:1.14.12.10 1.14.12.-] path:map00362,path:map00364,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Fluorobenzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 160.0 12.0 10.0 2.0 0.857142857142857 Q 0.0 14.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 14.0 0.0 1.0 0.0077024991835335 0.0271079286472368 0.0174052139153851 0.0194054294637033 0 0 0 0 K05551 0.0 0.0256410256410256 actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] path:map00253,path:map01056,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 390.0 8.0 6.0 3.0 0.727272727272727 IQ 0.0 11.0 2.0 0.909090909090909 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 11.0 0.0 1.0 0.0035028733822491 0.0218151425901815 0.0126590079862153 0.0183122692079324 0 0 0 0 K05552 0.0 0.017094017094017 actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] path:map00253,path:map01056,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 401.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 6.0 0.0 1.0 3.67508439866827e-08 3.76896936853081e-12 1.8377306478025616e-08 3.674707501731417e-08 0 0 0 0 K05553 0.0 0.0227920227920227 actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein path:map00253,path:map01056,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 75.0 9.0 0.0 1.0 1.0 IQ 0.0 9.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 9.0 0.0 1.0 0.0035723957580716 0.0169790740994106 0.0102757349287411 0.013406678341339 0 0 0 0 K05554 0.0 0.0284900284900284 actVII; aromatase [EC:4.2.1.-] path:map01056,path:map01100,path:map01110 Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 146.0 10.0 0.0 1.0 1.0 I 0.0 10.0 1.0 1.0 COG2867 Ribosome_association_toxin_PasT_(RatA)_of_the_RatAB_toxin-antitoxin_module PasT 10.0 0.0 1.0 0.0091716212052994 0.0458055972178021 0.0274886092115507 0.0366339760125027 0 0 0 0 K05555 0.0085714285714285 0.0199430199430199 actIV; cyclase [EC:4.-.-.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 208.0 8.0 6.0 2.0 0.8 S 3.0 7.0 1.0 1.0 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 10.0 0.3 0.7 0.0774529273652295 0.286893507027438 0.1821732171963337 0.2094405796622084 0 0 0 0 K05556 0.0 0.0113960113960113 actVI1, RED1; ketoreductase RED1 [EC:1.1.1.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 298.0 5.0 0.0 1.0 1.0 I 0.0 5.0 1.0 1.0 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 5.0 0.0 1.0 0.002602136334064 0.0116791458075264 0.0071406410707952 0.0090770094734624 0 0 0 0 K05557 0.0 0.0085470085470085 actVA1; MFS transporter, DHA2 family, integral membrane protein 505.0 3.0 0.0 1.0 1.0 EGP 0.0 3.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 3.0 0.0 1.0 0 0 0 0 K05558 0.0057142857142857 0.0256410256410256 K05558; pyridoxamine 5'-phosphate oxidase family protein 107.0 12.0 10.0 2.0 0.857142857142857 S 3.0 11.0 2.0 0.642857142857143 COG3467 Nitroimidazole_reductase_NimA_or_a_related_FMN-containing_flavoprotein,_pyridoxamine_5'-phosphate_oxidase_superfamily NimA 14.0 0.2142857142857142 0.7857142857142857 0.0099086803830095 0.0197842427412831 0.0148464615621463 0.0098755623582736 0 0 0 0 K05559 0.0057142857142857 0.0911680911680911 phaA; multicomponent K+:H+ antiporter subunit A 669.0 33.0 27.0 2.0 0.846153846153846 CP 2.0 34.0 2.0 0.923076923076923 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 36.0 0.0555555555555555 0.9444444444444444 0.0262958534009449 0.135829663126846 0.0810627582638954 0.1095338097259011 0 0 0 0 K05560 0.0028571428571428 0.074074074074074 phaC; multicomponent K+:H+ antiporter subunit C 99.0 28.0 0.0 1.0 1.0 P 1.0 27.0 1.0 1.0 COG1006 Multisubunit_Na+/H+_antiporter,_MnhC_subunit MnhC 28.0 0.0357142857142857 0.9642857142857144 0.0336637159472532 0.151145200013686 0.0924044579804696 0.1174814840664328 0 0 0 0 K05561 0.0 0.0712250712250712 phaD; multicomponent K+:H+ antiporter subunit D 453.0 27.0 26.0 2.0 0.964285714285714 CP 0.0 28.0 1.0 1.0 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 28.0 0.0 1.0 0.0139432140145255 0.0341748865796998 0.0240590502971126 0.0202316725651742 0 0 0 0 K05562 0.0 0.0712250712250712 phaE; multicomponent K+:H+ antiporter subunit E 159.0 26.0 0.0 1.0 1.0 P 0.0 26.0 1.0 1.0 COG1863 Multisubunit_Na+/H+_antiporter,_MnhE_subunit MnhE 26.0 0.0 1.0 0.0149911095211304 0.019623812028313 0.0173074607747217 0.0046327025071825 0 0 0 0 K05563 0.0 0.0683760683760683 phaF; multicomponent K+:H+ antiporter subunit F 85.0 25.0 0.0 1.0 1.0 P 0.0 25.0 1.0 1.0 COG2212 Multisubunit_Na+/H+_antiporter,_MnhF_subunit MnhF 25.0 0.0 1.0 0.0231661567822425 0.0545119256786867 0.0388390412304646 0.0313457688964442 0 0 0 0 K05564 0.0114285714285714 0.0769230769230769 phaG; multicomponent K+:H+ antiporter subunit G 82.0 32.0 0.0 1.0 1.0 P 4.0 28.0 2.0 0.75 COG1320 Multisubunit_Na+/H+_antiporter,_MnhG_subunit MnhG 32.0 0.125 0.875 0.0293208004236055 0.0418383445091928 0.0355795724663991 0.0125175440855873 0 0 0 0 K05565 0.1657142857142857 0.168091168091168 mnhA, mrpA; multicomponent Na+:H+ antiporter subunit A 268.0 74.0 24.0 3.0 0.486842105263158 CP 72.0 78.0 5.0 0.842105263157895 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 150.0 0.48 0.52 0.411782955951133 0.356859338964018 0.3843211474575755 0.054923616987115 0 0 0 0 K05566 0.2742857142857143 0.2279202279202279 mnhB, mrpB; multicomponent Na+:H+ antiporter subunit B 56.0 307.0 306.0 2.0 0.996753246753247 P 193.0 114.0 3.0 0.944805194805195 COG2111 Multisubunit_Na+/H+_antiporter,_MnhB_subunit MnhB 307.0 0.6286644951140065 0.3713355048859935 0.565666953155388 0.369118516644362 0.467392734899875 0.1965484365110259 0 1 0 1 K05567 0.2885714285714286 0.2991452991452991 mnhC, mrpC; multicomponent Na+:H+ antiporter subunit C 79.0 263.0 247.0 2.0 0.942652329749104 P 148.0 131.0 1.0 1.0 COG1006 Multisubunit_Na+/H+_antiporter,_MnhC_subunit MnhC 279.0 0.5304659498207885 0.4695340501792114 0.927635813989862 0.92117730719374 0.924406560591801 0.0064585067961219 1 1 1 1 K05568 0.3628571428571429 0.3333333333333333 mnhD, mrpD; multicomponent Na+:H+ antiporter subunit D 214.0 254.0 29.0 4.0 0.517311608961303 C 276.0 215.0 6.0 0.967413441955194 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 491.0 0.5621181262729125 0.4378818737270876 0.788549275604321 0.978607424717917 0.883578350161119 0.1900581491135959 1 1 1 1 K05569 0.26 0.2792022792022792 mnhE, mrpE; multicomponent Na+:H+ antiporter subunit E 87.0 256.0 0.0 1.0 1.0 P 134.0 122.0 2.0 0.98828125 COG1863 Multisubunit_Na+/H+_antiporter,_MnhE_subunit MnhE 256.0 0.5234375 0.4765625 0.21485080083963 0.0300378769972941 0.122444338918462 0.1848129238423359 0 0 0 0 K05570 0.2514285714285714 0.2735042735042735 mnhF, mrpF; multicomponent Na+:H+ antiporter subunit F 67.0 240.0 0.0 1.0 1.0 P 130.0 120.0 3.0 0.96 COG2212 Multisubunit_Na+/H+_antiporter,_MnhF_subunit MnhF 250.0 0.52 0.48 0.937167926380418 0.939850988583036 0.938509457481727 0.0026830622026179 1 1 1 1 K05571 0.26 0.2991452991452991 mnhG, mrpG; multicomponent Na+:H+ antiporter subunit G 66.0 269.0 0.0 1.0 1.0 P 133.0 136.0 2.0 0.973977695167286 COG1320 Multisubunit_Na+/H+_antiporter,_MnhG_subunit MnhG 269.0 0.4944237918215613 0.5055762081784386 0.655694744239227 0.927142040868412 0.7914183925538195 0.271447296629185 0 1 0 1 K05572 0.0057142857142857 0.0626780626780626 ndhA; NAD(P)H-quinone oxidoreductase subunit 1 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 334.0 25.0 0.0 1.0 1.0 C 2.0 23.0 1.0 1.0 COG1005 NADH:ubiquinone_oxidoreductase_subunit_1_(chain_H) NuoH 25.0 0.08 0.92 0.0964696659515563 0.170163177607295 0.1333164217794256 0.0736935116557386 0 0 0 0 K05573 0.0 0.0541310541310541 ndhB; NAD(P)H-quinone oxidoreductase subunit 2 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 474.0 19.0 0.0 1.0 1.0 C 0.0 19.0 1.0 1.0 COG1007 NADH:ubiquinone_oxidoreductase_subunit_2_(chain_N) NuoN 19.0 0.0 1.0 0.009424012015632 0.0078817184947843 0.0086528652552081 0.0015422935208477 0 0 0 0 K05574 0.0171428571428571 0.0541310541310541 ndhC; NAD(P)H-quinone oxidoreductase subunit 3 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 118.0 25.0 0.0 1.0 1.0 C 6.0 19.0 1.0 1.0 COG0838 NADH:ubiquinone_oxidoreductase_subunit_3_(chain_A) NuoA 25.0 0.24 0.76 0.768652867167171 0.254039428550326 0.5113461478587484 0.5146134386168449 1 1 1 1 K05575 0.0142857142857142 0.0854700854700854 ndhD; NAD(P)H-quinone oxidoreductase subunit 4 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 426.0 82.0 78.0 2.0 0.953488372093023 C 5.0 81.0 2.0 0.941860465116279 COG1008 NADH:ubiquinone_oxidoreductase_subunit_4_(chain_M) NuoM 86.0 0.0581395348837209 0.9418604651162792 0.202917432464757 0.280269357974458 0.2415933952196075 0.077351925509701 0 0 0 0 K05576 0.1342857142857142 0.2279202279202279 ndhE; NAD(P)H-quinone oxidoreductase subunit 4L [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 85.0 139.0 0.0 1.0 1.0 C 49.0 92.0 4.0 0.943262411347518 COG0713 NADH:ubiquinone_oxidoreductase_subunit_11_or_4L_(chain_K) NuoK 141.0 0.3475177304964539 0.6524822695035462 0.221131727031319 0.843850888679026 0.5324913078551725 0.622719161647707 0 0 0 0 K05577 0.0771428571428571 0.131054131054131 ndhF; NAD(P)H-quinone oxidoreductase subunit 5 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 344.0 75.0 44.0 2.0 0.707547169811321 CP 29.0 77.0 1.0 1.0 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 106.0 0.2735849056603773 0.7264150943396226 0.0243220403934937 0.0741190945511133 0.0492205674723035 0.0497970541576196 0 0 0 0 K05578 0.0485714285714285 0.094017094017094 ndhG; NAD(P)H-quinone oxidoreductase subunit 6 [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 73.0 50.0 0.0 1.0 1.0 C 17.0 33.0 1.0 1.0 COG0839 NADH:ubiquinone_oxidoreductase_subunit_6_(chain_J) NuoJ 50.0 0.34 0.66 0.125523168916738 0.103376467334666 0.114449818125702 0.022146701582072 0 0 0 0 K05579 0.0 0.0541310541310541 ndhH; NAD(P)H-quinone oxidoreductase subunit H [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 372.0 20.0 0.0 1.0 1.0 C 0.0 20.0 1.0 1.0 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 20.0 0.0 1.0 0.282838307410196 0.0299695516895714 0.1564039295498837 0.2528687557206246 0 0 0 0 K05580 0.0257142857142857 0.1168091168091168 ndhI; NAD(P)H-quinone oxidoreductase subunit I [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 98.0 53.0 0.0 1.0 1.0 C 9.0 44.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 53.0 0.1698113207547169 0.8301886792452831 0.459943044759851 0.92220202512501 0.6910725349424305 0.462258980365159 0 0 0 0 K05581 0.0028571428571428 0.0512820512820512 ndhJ; NAD(P)H-quinone oxidoreductase subunit J [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 151.0 20.0 0.0 1.0 1.0 C 1.0 19.0 1.0 1.0 COG0852 NADH:ubiquinone_oxidoreductase_27_kD_subunit_(chain_C) NuoC 20.0 0.05 0.95 0.0108777671845931 0.0163806982868962 0.0136292327357446 0.0055029311023031 0 0 0 0 K05582 0.0 0.0455840455840455 ndhK; NAD(P)H-quinone oxidoreductase subunit K [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 220.0 19.0 0.0 1.0 1.0 C 0.0 19.0 1.0 1.0 COG0377 NADH:ubiquinone_oxidoreductase_20_kD_subunit_(chain_B)_or_related_Fe-S_oxidoreductase NuoB 19.0 0.0 1.0 1.19628312134466e-06 3.4905702851992e-09 5.998868458149295e-07 1.1927925510594609e-06 0 0 0 0 K05583 0.0 0.0341880341880341 ndhL; NAD(P)H-quinone oxidoreductase subunit L [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 69.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 2CICE 12.0 0.0 1.0 2.61511161397923e-05 0.0123068928116912 0.0061665219639154 0.0122807416955514 0 0 0 0 K05584 0.0 0.0398860398860398 ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 112.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 2AK12 14.0 0.0 1.0 0.0004775032301742 1.58891860979024e-12 0.0002387516158815 0.0004775032285852 0 0 0 0 K05585 0.0 0.0398860398860398 ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 158.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 28NKU 14.0 0.0 1.0 0.0005279394903709 0.0007419540428396 0.0006349467666052 0.0002140145524687 0 0 0 0 K05586 0.0 0.0484330484330484 hoxE; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 153.0 18.0 0.0 1.0 1.0 C 0.0 18.0 1.0 1.0 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 18.0 0.0 1.0 0.031997552588253 0.235371655158652 0.1336846038734525 0.203374102570399 0 0 0 0 K05587 0.0028571428571428 0.0797720797720797 hoxF; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 498.0 34.0 0.0 1.0 1.0 C 2.0 32.0 1.0 1.0 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 34.0 0.0588235294117647 0.9411764705882352 0.0114722875453195 0.0538226742616525 0.032647480903486 0.042350386716333 0 0 0 0 K05588 0.0 0.0398860398860398 hoxU; bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 232.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 14.0 0.0 1.0 0.0262293763726472 0.109069851122186 0.0676496137474166 0.0828404747495388 0 0 0 0 K05589 0.0 0.2735042735042735 ftsB; cell division protein FtsB 32.0 97.0 0.0 1.0 1.0 D 0.0 97.0 1.0 1.0 COG2919 Cell_division_protein_FtsB FtsB 97.0 0.0 1.0 0.0161260639438738 0.0171799164481798 0.0166529901960268 0.0010538525043059 0 0 0 0 K05590 0.0028571428571428 0.0284900284900284 srmB; ATP-dependent RNA helicase SrmB [EC:3.6.4.13] 400.0 6.0 3.0 3.0 0.545454545454545 JKL 1.0 10.0 1.0 1.0 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 11.0 0.0909090909090909 0.9090909090909092 0 0 0 0 K05591 0.0 0.1139601139601139 dbpA; ATP-dependent RNA helicase DbpA [EC:3.6.4.13] 383.0 34.0 27.0 3.0 0.80952380952381 L 0.0 42.0 1.0 1.0 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 42.0 0.0 1.0 0.0152309916941715 0.0273536298691965 0.021292310781684 0.012122638175025 0 0 0 0 K05592 0.4942857142857143 0.6609686609686609 deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13] path:map03018 RNA degradation 217.0 398.0 298.0 5.0 0.768339768339768 L 207.0 310.0 3.0 0.988416988416988 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 517.0 0.4003868471953578 0.5996131528046421 0.703865238084305 0.854488645130992 0.7791769416076485 0.1506234070466869 0 1 0 1 K05593 0.0057142857142857 0.0398860398860398 aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-] 221.0 7.0 1.0 5.0 0.388888888888889 G 2.0 16.0 3.0 0.611111111111111 2DB8K 18.0 0.1111111111111111 0.8888888888888888 0.0329600648391035 0.0806948494984007 0.056827457168752 0.0477347846592971 0 0 0 0 K05594 0.0 0.0056980056980056 elaB; ElaB protein 98.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG4575 Membrane-anchored_ribosome-binding_protein_ElaB,_inhibits_growth_in_stationary_phase,_YqjD/DUF883_family ElaB 2.0 0.0 1.0 0 0 0 0 K05595 0.4314285714285714 0.3903133903133903 marC; multiple antibiotic resistance protein 116.0 390.0 0.0 1.0 1.0 U 204.0 186.0 1.0 1.0 COG2095 Small_neutral_amino_acid_transporter_SnatA,_MarC_family MarC 390.0 0.5230769230769231 0.4769230769230769 0.0082755913589465 0.0142796836313053 0.0112776374951258 0.0060040922723587 0 0 0 0 K05596 0.0 0.094017094017094 iciA; LysR family transcriptional regulator, chromosome initiation inhibitor 233.0 36.0 0.0 1.0 1.0 K 0.0 36.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 36.0 0.0 1.0 0.0046718176850889 0.0102861500459447 0.0074789838655168 0.0056143323608558 0 0 0 0 K05597 0.0028571428571428 0.0199430199430199 aspQ, ansB, ansA; glutamin-(asparagin-)ase [EC:3.5.1.38] path:map00220,path:map00250,path:map00470,path:map01100,path:map01110,path:map02020 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,D-Amino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Two-component system 318.0 8.0 0.0 1.0 1.0 EJ 1.0 7.0 1.0 1.0 COG0252 L-asparaginase/archaeal_Glu-tRNAGln_amidotransferase_subunit_D AnsA 8.0 0.125 0.875 0.0561458358110161 0.0798005743180735 0.0679732050645448 0.0236547385070573 0 0 0 0 K05599 0.0 0.0028490028490028 antA; anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit [EC:1.14.12.1] path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 466.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 1.0 0.0 1.0 0 0 0 0 K05600 0.0 0.0028490028490028 antB; anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit [EC:1.14.12.1] path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 162.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K05601 0.1457142857142857 0.2592592592592592 hcp; hydroxylamine reductase [EC:1.7.99.1] path:map00910,path:map01100 Nitrogen metabolism,Metabolic pathways 400.0 169.0 163.0 2.0 0.965714285714286 C 61.0 114.0 2.0 0.994285714285714 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 175.0 0.3485714285714286 0.6514285714285715 0.0511403904267309 0.205331920535877 0.1282361554813039 0.1541915301091461 0 0 0 0 K05602 0.0028571428571428 0.1082621082621082 hisN; histidinol-phosphatase [EC:3.1.3.15] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 221.0 41.0 0.0 1.0 1.0 G 1.0 40.0 1.0 1.0 COG0483 Archaeal_fructose-1,6-bisphosphatase_or_related_enzyme,_inositol_monophosphatase_family SuhB 41.0 0.024390243902439 0.975609756097561 0.0131248145861344 0.138108557808619 0.0756166861973767 0.1249837432224846 0 0 0 0 K05603 0.0 0.0655270655270655 hutF; formimidoylglutamate deiminase [EC:3.5.3.13] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 415.0 23.0 0.0 1.0 1.0 F 0.0 23.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 23.0 0.0 1.0 0.0200148760193758 0.041280796757655 0.0306478363885154 0.0212659207382792 0 0 0 0 K05605 0.0 0.0256410256410256 HIBCH; 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] path:map00280,path:map00410,path:map00640,path:map01100,path:map01200 Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Propanoate metabolism,Metabolic pathways,Carbon metabolism 338.0 9.0 0.0 1.0 1.0 I 0.0 9.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 9.0 0.0 1.0 0.0012992921841855 2.85748886985137e-06 0.0006510748365276 0.0012964346953156 0 0 0 0 K05606 0.2914285714285714 0.4643874643874643 MCEE, epi; methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 52.0 318.0 317.0 3.0 0.99375 E 123.0 197.0 3.0 0.978125 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 320.0 0.384375 0.615625 0.037121272966022 0.353086808214526 0.195104040590274 0.3159655352485039 0 0 0 0 K05609 0.0028571428571428 0.0 UCHL3, YUH1; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12] 169.0 1.0 0.0 1.0 1.0 BDLTU 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K05641 0.0028571428571428 0.0 ABCA1; ATP-binding cassette, subfamily A (ABC1), member 1 path:map02010,path:map04975,path:map04979,path:map05417 ABC transporters,Fat digestion and absorption,Cholesterol metabolism,Lipid and atherosclerosis 722.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 1.0 1.0 0.0 0 0 0 0 K05643 0.0028571428571428 0.0 ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3 path:map02010 ABC transporters 722.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 1.0 1.0 0.0 0 0 0 0 K05644 0.0 0.0028490028490028 ABCA4; ATP-binding cassette, subfamily A (ABC1), member 4 path:map02010 ABC transporters 230.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 1.0 0.0 1.0 0 0 0 0 K05658 0.0 0.0028490028490028 ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] path:map02010,path:map04976,path:map05206,path:map05226 ABC transporters,Bile secretion,MicroRNAs in cancer,Gastric cancer 261.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 1.0 0.0 1.0 0 0 0 0 K05685 0.0057142857142857 0.1908831908831909 macB; macrolide transport system ATP-binding/permease protein [EC:7.6.2.-] path:map02010 ABC transporters 153.0 85.0 83.0 3.0 0.965909090909091 V 2.0 79.0 3.0 0.579545454545455 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 81.0 0.0246913580246913 0.9753086419753086 0.203743176879901 0.481775101295462 0.3427591390876815 0.278031924415561 0 0 0 0 K05687 0.0 0.0227920227920227 PARK7; protein DJ-1 [EC:3.5.1.124] path:map05012,path:map05022 Parkinson disease,Pathways of neurodegeneration - multiple diseases 177.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG0693 Protein/nucleotide_deglycase,_PfpI/YajL/DJ-1_family_(repair_of_methylglyoxal-glycated_proteins_and_nucleic_acids) YajL 8.0 0.0 1.0 0.0252039937198204 0.10900927212656 0.0671066329231902 0.0838052784067396 0 0 0 0 K05692 0.0342857142857142 0.0056980056980056 ACTB_G1; actin beta/gamma 1 path:map04015,path:map04145,path:map04210,path:map04390,path:map04391,path:map04510,path:map04520,path:map04530,path:map04611,path:map04613,path:map04670,path:map04714,path:map04745,path:map04810,path:map04919,path:map04921,path:map04971,path:map05014,path:map05100,path:map05110,path:map05130,path:map05131,path:map05132,path:map05135,path:map05164,path:map05205,path:map05225,path:map05410,path:map05412,path:map05414,path:map05416,path:map05418 Rap1 signaling pathway,Phagosome,Apoptosis,Hippo signaling pathway,Hippo signaling pathway - fly,Focal adhesion,Adherens junction,Tight junction,Platelet activation,Neutrophil extracellular trap formation,Leukocyte transendothelial migration,Thermogenesis,Phototransduction - fly,Regulation of actin cytoskeleton,Thyroid hormone signaling pathway,Oxytocin signaling pathway,Gastric acid secretion,Amyotrophic lateral sclerosis,Bacterial invasion of epithelial cells,Vibrio cholerae infection,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Yersinia infection,Influenza A,Proteoglycans in cancer,Hepatocellular carcinoma,Hypertrophic cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy,Dilated cardiomyopathy,Viral myocarditis,Fluid shear stress and atherosclerosis 331.0 19.0 0.0 1.0 1.0 Z 17.0 2.0 1.0 1.0 COG5277 Actin-related_protein 19.0 0.8947368421052632 0.1052631578947368 0.922691085848944 0.999999690381339 0.9613453881151416 0.0773086045323949 0 0 1 1 K05708 0.0028571428571428 0.0284900284900284 hcaE, hcaA1; 3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha [EC:1.14.12.19] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 353.0 15.0 13.0 2.0 0.882352941176471 P 1.0 16.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 17.0 0.0588235294117647 0.9411764705882352 0.0201772796159717 0.0512153327691643 0.035696306192568 0.0310380531531925 0 0 0 0 K05709 0.0 0.0028490028490028 hcaF, hcaA2; 3-phenylpropionate/trans-cinnamate dioxygenase subunit beta [EC:1.14.12.19] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 172.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K05710 0.1571428571428571 0.2991452991452991 hcaC; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 34.0 228.0 210.0 4.0 0.88030888030888 P 107.0 151.0 6.0 0.884169884169884 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 258.0 0.4147286821705426 0.5852713178294574 0.233688258642517 0.66917211857814 0.4514301886103284 0.435483859935623 0 0 0 0 K05711 0.0 0.017094017094017 hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 247.0 7.0 0.0 1.0 1.0 IQ 0.0 7.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 7.0 0.0 1.0 0.0179963771838259 0.251030715039307 0.1345135461115664 0.2330343378554811 0 0 0 0 K05712 0.0114285714285714 0.1111111111111111 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 221.0 60.0 43.0 2.0 0.779220779220779 CH 6.0 71.0 2.0 0.948051948051948 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 77.0 0.0779220779220779 0.922077922077922 0.0040414247215183 0.0353835563815314 0.0197124905515248 0.0313421316600131 0 0 0 0 K05713 0.0 0.0512820512820512 mhpB; 2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 195.0 11.0 4.0 2.0 0.611111111111111 S 0.0 18.0 2.0 0.5 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 18.0 0.0 1.0 0.0310627867110263 0.103462678109996 0.0672627324105111 0.0723998913989697 0 0 0 0 K05714 0.0028571428571428 0.0427350427350427 mhpC; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase [EC:3.7.1.14] path:map00360,path:map01100,path:map01120,path:map01220 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 242.0 11.0 6.0 5.0 0.55 I 1.0 19.0 3.0 0.6 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 20.0 0.05 0.95 0.0186493982824066 0.0702517309765333 0.0444505646294699 0.0516023326941267 0 0 0 0 K05715 0.0885714285714285 0.0199430199430199 2PGK; 2-phosphoglycerate kinase [EC:2.7.2.16] 237.0 27.0 12.0 2.0 0.642857142857143 F 35.0 7.0 1.0 1.0 COG2074 2-phosphoglycerate_kinase/Mevalonate-3-phosphate_5-kinase Pgk2 42.0 0.8333333333333334 0.1666666666666666 0.915312929503104 0.995270055909733 0.9552914927064184 0.0799571264066291 1 1 1 1 K05716 0.06 0.0313390313390313 CPGS; cyclic 2,3-diphosphoglycerate synthase [EC:6.5.1.9] 370.0 19.0 6.0 2.0 0.59375 F 21.0 11.0 1.0 1.0 COG2403 Zn/Ni/Co-binding_GTPase_YjiA,_predicted_metallochaperone,_CobW/Nha3/YciC_family YjiA 32.0 0.65625 0.34375 0.99746887308631 0.951005194462722 0.974237033774516 0.046463678623588 1 1 1 1 K05739 0.0 0.037037037037037 seaA; uncharacterized protein 278.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 28IBV 15.0 0.0 1.0 0.0001491654300186 0.219373852248404 0.1097615088392113 0.2192246868183854 0 0 0 0 K05761 0.0171428571428571 0.0 VIL1; villin 1 188.0 6.0 0.0 1.0 1.0 Z 6.0 0.0 1.0 1.0 KOG0443 6.0 1.0 0.0 0.0413082560174621 0.999999088580605 0.5206536722990336 0.9586908325631428 0 0 0 0 K05766 0.0057142857142857 0.0 SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48] path:map04360,path:map04810 Axon guidance,Regulation of actin cytoskeleton 149.0 2.0 0.0 1.0 1.0 V 2.0 0.0 1.0 1.0 COG2453 Protein-tyrosine_phosphatase CDC14 2.0 1.0 0.0 0 0 0 0 K05768 0.0257142857142857 0.0 GSN; gelsolin path:map04666,path:map04810,path:map05203 Fc gamma R-mediated phagocytosis,Regulation of actin cytoskeleton,Viral carcinogenesis 188.0 9.0 0.0 1.0 1.0 Z 9.0 0.0 1.0 1.0 KOG0443 9.0 1.0 0.0 0.714885331725393 0.9999996247006 0.8574424782129966 0.2851142929752069 0 0 0 1 K05770 0.2257142857142857 0.2364672364672364 TSPO, BZRP; translocator protein path:map04080,path:map04214,path:map04979,path:map05166 Neuroactive ligand-receptor interaction,Apoptosis - fly,Cholesterol metabolism,Human T-cell leukemia virus 1 infection 117.0 180.0 0.0 1.0 1.0 T 82.0 98.0 1.0 1.0 COG3476 Tryptophan-rich_sensory_protein_TspO/CrtK_(mitochondrial_benzodiazepine_receptor_homolog) TspO 180.0 0.4555555555555555 0.5444444444444444 0.0138603707229177 0.0501329597537196 0.0319966652383186 0.0362725890308019 0 0 0 0 K05772 0.2485714285714285 0.1794871794871795 tupA, vupA; tungstate transport system substrate-binding protein path:map02010 ABC transporters 188.0 153.0 128.0 3.0 0.854748603351955 H 101.0 78.0 3.0 0.877094972067039 COG2998 ABC-type_tungstate_transport_system,_permease_component_TupA TupB 179.0 0.5642458100558659 0.435754189944134 0.705973726267061 0.784934992443895 0.745454359355478 0.0789612661768339 0 1 0 1 K05773 0.2428571428571428 0.1623931623931624 tupB, vupB; tungstate transport system permease protein path:map02010 ABC transporters 196.0 127.0 108.0 3.0 0.863945578231292 P 89.0 58.0 2.0 0.993197278911565 COG4662 ABC-type_tungstate_transport_system,_periplasmic_component TupA 147.0 0.6054421768707483 0.3945578231292517 0.812114881845867 0.866690433526819 0.8394026576863429 0.0545755516809519 1 1 1 1 K05774 0.02 0.0455840455840455 phnN; ribose 1,5-bisphosphokinase [EC:2.7.4.23] path:map00030,path:map01100 Pentose phosphate pathway,Metabolic pathways 158.0 15.0 8.0 3.0 0.652173913043478 P 7.0 16.0 1.0 1.0 COG3709 Ribose_1,5-bisphosphate_kinase_PhnN PhnN 23.0 0.3043478260869565 0.6956521739130435 0.596159823717318 0.233733639152674 0.414946731434996 0.362426184564644 0 1 0 1 K05775 0.0 0.0056980056980056 malM; maltose operon periplasmic protein 275.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2C19D 2.0 0.0 1.0 0 0 0 0 K05776 0.0 0.131054131054131 modF; molybdate transport system ATP-binding protein path:map02010 ABC transporters 138.0 41.0 37.0 5.0 0.854166666666667 P 0.0 48.0 4.0 0.791666666666667 COG1119 ABC-type_molybdenum_transport_system,_ATPase_component_ModF/photorepair_protein_PhrA ModF 48.0 0.0 1.0 0.0217506668842919 0.0492130473848232 0.0354818571345575 0.0274623805005313 0 0 0 0 K05777 0.0 0.0455840455840455 ynjB; putative thiamine transport system substrate-binding protein 370.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG4134 ABC-type_uncharacterized_transport_system_YnjBCD,_periplasmic_component YnjB 17.0 0.0 1.0 0.0290553152022244 0.077205207114461 0.0531302611583427 0.0481498919122365 0 0 0 0 K05778 0.0 0.0313390313390313 ynjC; putative thiamine transport system permease protein 551.0 11.0 0.0 1.0 1.0 P 0.0 11.0 1.0 1.0 COG4135 ABC-type_uncharacterized_transport_system_YnjBCD,_permease_component YnjC 11.0 0.0 1.0 0.0147133376050743 0.0377572665672095 0.0262353020861419 0.0230439289621352 0 0 0 0 K05779 0.0 0.0341880341880341 ynjD; putative thiamine transport system ATP-binding protein 199.0 11.0 10.0 2.0 0.916666666666667 S 0.0 12.0 1.0 1.0 COG4136 ABC-type_uncharacterized_transport_system_YnjBCD,_ATPase_component YnjD 12.0 0.0 1.0 0.015401308731198 0.029958560307826 0.022679934519512 0.0145572515766279 0 0 0 0 K05780 0.0171428571428571 0.0883190883190883 phnL; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [EC:2.7.8.37] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 207.0 33.0 28.0 2.0 0.868421052631579 P 6.0 32.0 2.0 0.868421052631579 COG4778 Alpha-D-ribose_1-methylphosphonate_5-triphosphate_synthase_subunit_PhnL PhnL 38.0 0.1578947368421052 0.8421052631578947 0.0313050086243911 0.0951379200532704 0.0632214643388307 0.0638329114288793 0 0 0 0 K05781 0.0171428571428571 0.0854700854700854 phnK; putative phosphonate transport system ATP-binding protein 233.0 33.0 28.0 2.0 0.868421052631579 P 6.0 32.0 2.0 0.868421052631579 COG4107 ABC-type_phosphonate_transport_system,_ATPase_component_PhnK PhnK 38.0 0.1578947368421052 0.8421052631578947 0.0244654642677944 0.131564446603354 0.0780149554355742 0.1070989823355596 0 0 0 0 K05782 0.0 0.1082621082621082 benE; benzoate membrane transport protein 362.0 44.0 0.0 1.0 1.0 Q 0.0 44.0 1.0 1.0 COG3135 Predicted_benzoate:H+_symporter_BenE BenE 44.0 0.0 1.0 0.0041518152834665 0.0118253456465657 0.0079885804650161 0.0076735303630992 0 0 0 0 K05783 0.0 0.0455840455840455 benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-] path:map00362,path:map00364,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Fluorobenzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 237.0 19.0 0.0 1.0 1.0 IQ 0.0 19.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 19.0 0.0 1.0 0.0022245178530805 0.0137030251248912 0.0079637714889858 0.0114785072718107 0 0 0 0 K05784 0.0114285714285714 0.0598290598290598 benC-xylZ; benzoate/toluate 1,2-dioxygenase reductase component [EC:1.18.1.-] path:map00362,path:map00364,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Fluorobenzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 155.0 23.0 20.0 2.0 0.884615384615385 C 4.0 22.0 3.0 0.769230769230769 COG0543 NAD(P)H-flavin_reductase Mcr1 26.0 0.1538461538461538 0.8461538461538461 0.76611843127401 0.360416572992216 0.563267502133113 0.405701858281794 1 1 1 1 K05785 0.0 0.1424501424501424 rfaH; transcriptional antiterminator RfaH 91.0 51.0 0.0 1.0 1.0 K 0.0 51.0 1.0 1.0 COG0250 Transcription_termination/antitermination_protein_NusG NusG 51.0 0.0 1.0 0.303003432173686 0.0322923236975946 0.1676478779356403 0.2707111084760914 0 0 0 0 K05786 0.0 0.2592592592592592 rarD; chloramphenicol-sensitive protein RarD 249.0 96.0 0.0 1.0 1.0 S 0.0 96.0 1.0 1.0 COG2962 Membrane_protein_RarD,_contains_two_EamA_domains,_drug/metabolite_transporter_family RarD 96.0 0.0 1.0 0.0028928810760566 0.500900408726593 0.2518966449013248 0.4980075276505364 0 0 0 0 K05787 0.0 0.037037037037037 hupA; DNA-binding protein HU-alpha 90.0 14.0 0.0 1.0 1.0 L 0.0 14.0 1.0 1.0 COG0776 Bacterial_nucleoid_DNA-binding_protein_IHF-alpha HimA 14.0 0.0 1.0 0.025810285948891 0.048874035342876 0.0373421606458835 0.023063749393985 0 0 0 0 K05788 0.0028571428571428 0.3789173789173789 ihfB, himD; integration host factor subunit beta 79.0 109.0 42.0 3.0 0.615819209039548 L 1.0 176.0 2.0 0.994350282485876 COG0776 Bacterial_nucleoid_DNA-binding_protein_IHF-alpha HimA 177.0 0.0056497175141242 0.9943502824858758 0.0328200516562134 0.0161399136229276 0.0244799826395704 0.0166801380332858 0 0 0 0 K05789 0.0 0.0541310541310541 wzzB; chain length determinant protein (polysaccharide antigen chain regulator) 206.0 21.0 0.0 1.0 1.0 M 0.0 21.0 2.0 0.857142857142857 COG3206 Exopolysaccharide_export_protein/domain_GumC/Wzc1 GumC 21.0 0.0 1.0 0.81900579752861 0.798334008981999 0.8086699032553045 0.020671788546611 0 0 1 1 K05790 0.0 0.0142450142450142 wzzE; lipopolysaccharide biosynthesis protein WzzE 305.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG3765 LPS_O-antigen_chain_length_determinant_protein,_WzzB/FepE_family WzzB 5.0 0.0 1.0 0.0001798058169331 9.52378561215675e-12 8.990291322844281e-05 0.0001798058074093 0 0 0 0 K05791 0.0 0.017094017094017 terZ; tellurium resistance protein TerZ 181.0 10.0 0.0 1.0 1.0 T 0.0 10.0 1.0 1.0 COG2310 Stress_response_protein_SCP2 TerZ 10.0 0.0 1.0 0.0051115979280145 0.012031199711381 0.0085713988196977 0.0069196017833665 0 0 0 0 K05792 0.0 0.0256410256410256 terA; tellurite resistance protein TerA 203.0 6.0 3.0 4.0 0.545454545454545 T 0.0 11.0 3.0 0.454545454545455 COG2310 Stress_response_protein_SCP2 TerZ 11.0 0.0 1.0 0.0059463351000391 0.0097518763148766 0.0078491057074578 0.0038055412148375 0 0 0 0 K05793 0.0 0.0256410256410256 terB; tellurite resistance protein TerB 92.0 6.0 3.0 2.0 0.666666666666667 P 0.0 9.0 2.0 0.666666666666667 COG3793 Tellurite_resistance_protein_TerB TerB 9.0 0.0 1.0 0.141262299548854 0.305968372885872 0.223615336217363 0.1647060733370179 0 0 0 0 K05794 0.06 0.2735042735042735 terC; tellurite resistance protein TerC 249.0 155.0 0.0 1.0 1.0 P 26.0 129.0 1.0 1.0 COG0861 Tellurite_resistance_membrane_protein_TerC TerC 155.0 0.1677419354838709 0.832258064516129 0.0144113101069968 0.394808084557366 0.2046096973321814 0.3803967744503692 0 0 0 0 K05795 0.0 0.0569800569800569 terD; tellurium resistance protein TerD 171.0 48.0 47.0 2.0 0.979591836734694 T 0.0 49.0 1.0 1.0 COG2310 Stress_response_protein_SCP2 TerZ 49.0 0.0 1.0 0.0006658083167183 0.0016745848456717 0.001170196581195 0.0010087765289534 0 0 0 0 K05796 0.02 0.0341880341880341 hydN; electron transport protein HydN 107.0 23.0 0.0 1.0 1.0 C 8.0 15.0 1.0 1.0 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 23.0 0.3478260869565217 0.6521739130434783 0.159587925015537 0.543608689983334 0.3515983074994355 0.384020764967797 0 0 0 0 K05797 0.0142857142857142 0.0313390313390313 pchF; 4-cresol dehydrogenase (hydroxylating) flavoprotein subunit [EC:1.17.9.1] path:map00623,path:map01100,path:map01120 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments 323.0 21.0 0.0 1.0 1.0 C 7.0 14.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 21.0 0.3333333333333333 0.6666666666666666 0.0207847331677507 0.0343276116812687 0.0275561724245097 0.013542878513518 0 0 0 0 K05798 0.0 0.0113960113960113 leuO; LysR family transcriptional regulator, transcriptional activator for leuABCD operon 293.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 2.7910358556616102e-09 1.10720245284898e-07 5.6755640570279814e-08 1.0792920942923638e-07 0 0 0 0 K05799 0.0 0.3219373219373219 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex 59.0 241.0 0.0 1.0 1.0 K 0.0 241.0 2.0 0.995850622406639 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 241.0 0.0 1.0 0.0020958298170745 0.500658795741198 0.2513773127791362 0.4985629659241234 0 0 0 0 K05800 0.0371428571428571 0.131054131054131 ybaO; Lrp/AsnC family transcriptional regulator 118.0 89.0 0.0 1.0 1.0 K 14.0 75.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 89.0 0.1573033707865168 0.8426966292134831 0.0054314129537336 0.0081206520397442 0.0067760324967388 0.0026892390860106 0 0 0 0 K05801 0.0 0.2364672364672364 djlA; DnaJ like chaperone protein 74.0 89.0 86.0 2.0 0.967391304347826 O 0.0 92.0 5.0 0.771739130434783 COG1076 DnaJ_domain-containing_protein DjlA 92.0 0.0 1.0 0.0260222066310298 0.71780037477226 0.3719112907016449 0.6917781681412302 0 0 0 0 K05802 0.1314285714285714 0.2022792022792023 mscK, kefA, aefA; potassium-dependent mechanosensitive channel 130.0 120.0 109.0 5.0 0.882352941176471 M 49.0 87.0 11.0 0.647058823529412 COG3264 Small-conductance_mechanosensitive_channel_MscK MscK 136.0 0.3602941176470588 0.6397058823529411 0.966680093152928 0.278970640726312 0.62282536693962 0.6877094524266161 1 1 1 1 K05803 0.0 0.0313390313390313 nlpI; lipoprotein NlpI 268.0 8.0 6.0 3.0 0.727272727272727 S 0.0 11.0 1.0 1.0 COG4785 Lipoprotein_NlpI,_contains_TPR_repeats NlpI 11.0 0.0 1.0 0.0008310217617455 0.0018858851222257 0.0013584534419856 0.0010548633604802 0 0 0 0 K05804 0.0 0.017094017094017 rob; AraC family transcriptional regulator, mar-sox-rob regulon activator 102.0 11.0 0.0 1.0 1.0 K 0.0 11.0 2.0 0.909090909090909 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 11.0 0.0 1.0 0.0041404938574188 0.0085269993139361 0.0063337465856774 0.0043865054565172 0 0 0 0 K05805 0.0 0.0626780626780626 creA; CreA protein 129.0 24.0 0.0 1.0 1.0 S 0.0 24.0 1.0 1.0 COG3045 Periplasmic_catabolite_regulation_protein_CreA_(function_unknown) CreA 24.0 0.0 1.0 0.0066670842656688 0.0185388496792381 0.0126029669724534 0.0118717654135693 0 0 0 0 K05807 0.0028571428571428 0.4786324786324786 bamD; outer membrane protein assembly factor BamD 32.0 89.0 0.0 3.0 0.494444444444444 M 1.0 179.0 6.0 0.9 COG4105 Outer_membrane_protein_assembly_factor_BamD,_BamD/ComL_family BamD 180.0 0.0055555555555555 0.9944444444444444 0.0022453311973096 0.0046877131573996 0.0034665221773546 0.00244238196009 0 0 0 0 K05808 0.0 0.7834757834757835 yhbH; putative sigma-54 modulation protein 31.0 295.0 292.0 3.0 0.983333333333333 J 0.0 300.0 4.0 0.973333333333333 COG1544 Ribosome-associated_translation_inhibitor_RaiA RaiA 300.0 0.0 1.0 0.050714218065468 0.0520045898003036 0.0513594039328857 0.0012903717348356 0 0 0 0 K05809 0.0 0.0826210826210826 raiA; ribosome-associated inhibitor A 63.0 30.0 0.0 1.0 1.0 J 0.0 30.0 2.0 0.966666666666667 COG1544 Ribosome-associated_translation_inhibitor_RaiA RaiA 30.0 0.0 1.0 0.870703637605765 0.49845350981845 0.6845785737121075 0.372250127787315 0 0 1 1 K05810 0.0028571428571428 0.7350427350427351 LACC1, yfiH; purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4] path:map00230,path:map00270,path:map01100,path:map01232 Purine metabolism,Cysteine and methionine metabolism,Metabolic pathways,Nucleotide metabolism 58.0 254.0 250.0 3.0 0.976923076923077 S 1.0 259.0 1.0 1.0 COG1496 Copper_oxidase_(laccase)_domain YfiH 260.0 0.0038461538461538 0.9961538461538462 0.0606326793286897 0.128172254794913 0.0944024670618013 0.0675395754662233 0 0 0 0 K05811 0.0 0.0313390313390313 yfiM; putative lipoprotein 86.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG5544 Uncharacterized_conserved_protein_YfiM,_DUF2279_family yfiM 11.0 0.0 1.0 0.0217546833298734 0.048081169370432 0.0349179263501527 0.0263264860405585 0 0 0 0 K05812 0.0 0.0598290598290598 DTWD2, tapT; tRNA-uridine aminocarboxypropyltransferase [EC:2.5.1.25] 123.0 27.0 0.0 1.0 1.0 S 0.0 27.0 1.0 1.0 COG3148 tRNA_U47_aminocarboxypropyltransferaseTapT/TuaA/_YfiP,_DTW_domain TapT 27.0 0.0 1.0 0.008958136221162 0.0149293007120424 0.0119437184666022 0.0059711644908804 0 0 0 0 K05813 0.0371428571428571 0.188034188034188 ugpB; sn-glycerol 3-phosphate transport system substrate-binding protein path:map02010 ABC transporters 171.0 109.0 105.0 2.0 0.964601769911504 G 18.0 95.0 3.0 0.929203539823009 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 113.0 0.1592920353982301 0.8407079646017699 0.548375259764847 0.908893554577517 0.728634407171182 0.3605182948126699 0 1 0 1 K05814 0.0342857142857142 0.1937321937321937 ugpA; sn-glycerol 3-phosphate transport system permease protein path:map02010 ABC transporters 200.0 96.0 51.0 3.0 0.671328671328671 P 12.0 131.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 143.0 0.0839160839160839 0.916083916083916 0.137681484726155 0.731879158311034 0.4347803215185944 0.5941976735848791 0 0 0 0 K05815 0.0314285714285714 0.1851851851851851 ugpE; sn-glycerol 3-phosphate transport system permease protein path:map02010 ABC transporters 207.0 60.0 19.0 3.0 0.576923076923077 P 11.0 93.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 104.0 0.1057692307692307 0.8942307692307693 0.22653289529432 0.741732134463846 0.484132514879083 0.515199239169526 0 0 0 0 K05816 0.0028571428571428 0.1538461538461538 ugpC; sn-glycerol 3-phosphate transport system ATP-binding protein [EC:7.6.2.10] path:map02010 ABC transporters 283.0 52.0 33.0 2.0 0.732394366197183 P 1.0 70.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 71.0 0.0140845070422535 0.9859154929577464 0.713289752765989 0.805647766655187 0.759468759710588 0.0923580138891979 0 0 0 1 K05817 0.0 0.0113960113960113 hcaR; LysR family transcriptional regulator, hca operon transcriptional activator 289.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.018737012797902 0.0440221131896509 0.0313795629937764 0.0252851003917489 0 0 0 0 K05818 0.0 0.0341880341880341 mhpR; IclR family transcriptional regulator, mhp operon transcriptional activator 207.0 19.0 0.0 1.0 1.0 K 0.0 19.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 19.0 0.0 1.0 0.0050189045836404 0.0103965767642749 0.0077077406739576 0.0053776721806344 0 0 0 0 K05819 0.0 0.0142450142450142 mhpT; MFS transporter, AAHS family, 3-hydroxyphenylpropionic acid transporter 379.0 4.0 3.0 2.0 0.8 EGP 0.0 5.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 5.0 0.0 1.0 0 0 0 0 K05820 0.02 0.2222222222222222 hcaT; MFS transporter, PPP family, 3-phenylpropionic acid transporter 195.0 74.0 62.0 4.0 0.787234042553192 EGP 8.0 86.0 6.0 0.819148936170213 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 94.0 0.0851063829787234 0.9148936170212766 0 0 0 0 K05822 0.0028571428571428 0.0854700854700854 dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89] path:map00300,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 225.0 32.0 0.0 1.0 1.0 E 1.0 31.0 1.0 1.0 COG2171 Tetrahydrodipicolinate_N-succinyltransferase DapD 32.0 0.03125 0.96875 0.015460683964392 0.0360037609516447 0.0257322224580183 0.0205430769872527 0 0 0 0 K05823 0.0 0.0712250712250712 dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47] path:map00300,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 324.0 18.0 10.0 2.0 0.692307692307692 E 0.0 26.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 26.0 0.0 1.0 0.0167613507227201 0.0376004463900363 0.0271808985563782 0.0208390956673161 0 0 0 0 K05824 0.0057142857142857 0.0227920227920227 LYS12; homoisocitrate dehydrogenase [EC:1.1.1.87] path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 323.0 5.0 0.0 2.0 0.5 C 2.0 8.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 10.0 0.2 0.8 0.0172714957258419 0.537937662577124 0.2776045791514829 0.5206661668512822 0 0 0 0 K05825 0.2342857142857143 0.2792022792022792 LYSN; 2-aminoadipate transaminase [EC:2.6.1.-] path:map00300,path:map01100,path:map01110,path:map01210 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism 255.0 103.0 4.0 3.0 0.438297872340426 EK 110.0 125.0 1.0 1.0 COG1167 DNA-binding_transcriptional_regulator,_MocR_family,_contains_an_aminotransferase_domain ARO8 235.0 0.4680851063829787 0.5319148936170213 0.6894400470617 0.693041534054533 0.6912407905581165 0.0036014869928329 0 1 0 1 K05826 0.3171428571428571 0.0541310541310541 lysW; alpha-aminoadipate/glutamate carrier protein LysW 47.0 93.0 43.0 2.0 0.65034965034965 E 127.0 20.0 6.0 0.795918367346939 arCOG01588 147.0 0.8639455782312925 0.1360544217687075 0.099511356528056 0.731786253947513 0.4156488052377844 0.632274897419457 0 0 0 0 K05827 0.3685714285714285 0.0683760683760683 lysX; [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase [EC:6.3.2.43] path:map00300,path:map01100,path:map01210,path:map01230 Lysine biosynthesis,Metabolic pathways,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 202.0 140.0 75.0 2.0 0.682926829268293 H 180.0 25.0 1.0 1.0 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 205.0 0.8780487804878049 0.1219512195121951 0.149667013847428 0.952606473931 0.551136743889214 0.802939460083572 0 0 0 0 K05828 0.3371428571428571 0.0484330484330484 lysZ, argB; [amino group carrier protein]-L-2-aminoadipate/L-glutamate 6-kinase [EC:2.7.2.17 2.7.2.19] path:map00220,path:map00300,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 238.0 133.0 127.0 2.0 0.956834532374101 E 122.0 17.0 1.0 1.0 COG0548 N-acetylglutamate_kinase ArgB 139.0 0.8776978417266187 0.1223021582733813 0.0750515730783849 0.761173722186457 0.4181126476324209 0.686122149108072 0 0 0 0 K05829 0.3457142857142857 0.0512820512820512 lysY, argC; [amino group carrier protein]-6-phospho-L-2-aminoadipate/5-phospho-L-glutamate reductase [EC:1.2.1.103 1.2.1.106] path:map00220,path:map00300,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 309.0 141.0 0.0 1.0 1.0 E 123.0 18.0 1.0 1.0 COG0002 N-acetyl-gamma-glutamylphosphate_reductase ArgC 141.0 0.8723404255319149 0.1276595744680851 0.840076657047559 0.554250052997817 0.697163355022688 0.2858266040497419 1 1 1 1 K05830 0.3542857142857142 0.0541310541310541 lysJ, argD; [amino-group carrier protein]-gamma-(L-lysyl/L-ornithyl)-L-glutamate aminotransferase [EC:2.6.1.118 2.6.1.124] path:map00220,path:map00300,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 299.0 150.0 0.0 1.0 1.0 E 130.0 20.0 2.0 0.98 COG4992 Acetylornithine/succinyldiaminopimelate/putrescine_aminotransferase ArgD 150.0 0.8666666666666667 0.1333333333333333 0.896067512628807 0.0309643922823852 0.4635159524555961 0.8651031203464218 1 1 1 1 K05831 0.3142857142857143 0.0484330484330484 lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132] path:map00220,path:map00300,path:map01100,path:map01210,path:map01230 Arginine biosynthesis,Lysine biosynthesis,Metabolic pathways,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 200.0 132.0 0.0 1.0 1.0 E 114.0 18.0 2.0 0.962121212121212 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 132.0 0.8636363636363636 0.1363636363636363 0.593631295424586 0.662094955187207 0.6278631253058965 0.0684636597626209 0 1 0 1 K05832 0.0 0.1766381766381766 K05832; putative tryptophan/tyrosine transport system permease protein 235.0 63.0 56.0 3.0 0.818181818181818 S 0.0 77.0 2.0 0.896103896103896 COG4120 ABC-type_uncharacterized_transport_system,_permease_component 77.0 0.0 1.0 0.0165784099530303 0.654331322387566 0.3354548661702981 0.6377529124345357 0 0 0 0 K05833 0.0 0.168091168091168 K05833; putative tryptophan/tyrosine transport system ATP-binding protein 235.0 71.0 69.0 2.0 0.972602739726027 S 0.0 73.0 1.0 1.0 COG1101 ABC-type_uncharacterized_transport_system,_ATPase_component PhnK 73.0 0.0 1.0 0.0109580064538796 0.127294104409569 0.0691260554317243 0.1163360979556894 0 0 0 0 K05834 0.0 0.0512820512820512 rhtB; homoserine/homoserine lactone efflux protein 191.0 21.0 0.0 1.0 1.0 E 0.0 21.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 21.0 0.0 1.0 0.0222499760623082 0.055928917645031 0.0390894468536696 0.0336789415827228 0 0 0 0 K05835 0.0 0.0056980056980056 rhtC; threonine efflux protein 201.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 2.0 0.0 1.0 0 0 0 0 K05836 0.0 0.0797720797720797 hutC; GntR family transcriptional regulator, histidine utilization repressor 195.0 33.0 0.0 1.0 1.0 K 0.0 33.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 33.0 0.0 1.0 0.0099426978911202 0.0202219685570296 0.0150823332240749 0.0102792706659093 0 0 0 0 K05837 0.0 0.8433048433048433 rodA, mrdB; rod shape determining protein RodA 178.0 172.0 40.0 3.0 0.563934426229508 D 0.0 305.0 2.0 0.99344262295082 COG0772 Peptodoglycan_polymerase_FtsW/RodA/SpoVE FtsW 305.0 0.0 1.0 0.989515741336687 0.94510283816851 0.9673092897525986 0.0444129031681769 0 0 1 1 K05838 0.0285714285714285 0.3076923076923077 ybbN; putative thioredoxin 85.0 136.0 0.0 1.0 1.0 O 10.0 126.0 2.0 0.985294117647059 COG3118 Chaperedoxin_CnoX,_contains_thioredoxin-like_and_TPR-like_domains,_YbbN/TrxSC_family CnoX 136.0 0.0735294117647058 0.9264705882352942 0.0036360228125036 0.0110066067097197 0.0073213147611116 0.0073705838972161 0 0 0 0 K05839 0.0 0.0085470085470085 hha; haemolysin expression modulating protein 67.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 2CN5N 3.0 0.0 1.0 0 0 0 0 K05841 0.0 0.0398860398860398 E2.4.1.173; sterol 3beta-glucosyltransferase [EC:2.4.1.173] 326.0 21.0 20.0 2.0 0.954545454545455 CG 0.0 22.0 2.0 0.954545454545455 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 22.0 0.0 1.0 0.0129303383897935 0.0309556374281292 0.0219429879089613 0.0180252990383356 0 0 0 0 K05844 0.5257142857142857 0.301994301994302 rimK; ribosomal protein S6--L-glutamate ligase [EC:6.3.2.-] 34.0 191.0 64.0 6.0 0.503957783641161 HJ 227.0 151.0 2.0 0.997361477572559 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 378.0 0.6005291005291006 0.3994708994708995 0.661585835541576 0.501191193809184 0.58138851467538 0.160394641732392 0 1 0 1 K05845 0.0514285714285714 0.2905982905982906 opuC; osmoprotectant transport system substrate-binding protein path:map02010 ABC transporters 165.0 97.0 52.0 4.0 0.613924050632911 M 19.0 136.0 2.0 0.651898734177215 COG1732 Periplasmic_glycine_betaine/choline-binding_(lipo)protein_of_an_ABC-type_transport_system_(osmoprotectant_binding_protein) OsmF 155.0 0.1225806451612903 0.8774193548387097 0.101416966975094 0.939556066386374 0.520486516680734 0.8381390994112801 0 0 0 0 K05846 0.0342857142857142 0.2849002849002849 opuBD; osmoprotectant transport system permease protein path:map02010 ABC transporters 144.0 109.0 41.0 5.0 0.519047619047619 P 23.0 186.0 2.0 0.904761904761905 COG1174 ABC-type_proline/glycine_betaine_transport_system,_permease_component OpuBB 209.0 0.1100478468899521 0.8899521531100478 0.0257674316589094 0.831657622986854 0.4287125273228817 0.8058901913279446 0 0 0 0 K05847 0.0342857142857142 0.3105413105413105 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] path:map02010 ABC transporters 201.0 111.0 96.0 3.0 0.798561151079137 E 12.0 127.0 6.0 0.769784172661871 COG1125 ABC-type_proline/glycine_betaine_transport_system,_ATPase_component OpuBA 139.0 0.0863309352517985 0.9136690647482014 0.073384404830429 0.877580246569427 0.475482325699928 0.804195841738998 0 0 0 0 K05851 0.0 0.0427350427350427 cyaA; adenylate cyclase, class 1 [EC:4.6.1.1] path:map00230,path:map01100,path:map02026,path:map05111 Purine metabolism,Metabolic pathways,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 518.0 13.0 11.0 2.0 0.866666666666667 F 0.0 15.0 2.0 0.8 COG3072 Adenylate_cyclase,_class_I CyaA 15.0 0.0 1.0 0.0658409069824835 0.0945828885150359 0.0802118977487597 0.0287419815325524 0 0 0 0 K05857 0.0057142857142857 0.0 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11] path:map00562,path:map01100,path:map04020,path:map04070,path:map04919,path:map04933,path:map05131 Inositol phosphate metabolism,Metabolic pathways,Calcium signaling pathway,Phosphatidylinositol signaling system,Thyroid hormone signaling pathway,AGE-RAGE signaling pathway in diabetic complications,Shigellosis 454.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG1056 2.0 1.0 0.0 0 0 0 0 K05873 0.5571428571428572 0.1253561253561253 cyaB; adenylate cyclase, class 2 [EC:4.6.1.1] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 45.0 262.0 0.0 1.0 1.0 F 215.0 47.0 1.0 1.0 COG1437 Adenylate_cyclase_class_IV,_CYTH_domain_(includes_archaeal_enzymes_of_unknown_function) CyaB 262.0 0.8206106870229007 0.1793893129770992 0.44319444188596 0.11299350545638 0.27809397367117 0.33020093642958 0 0 0 0 K05874 0.0 0.0512820512820512 tsr; methyl-accepting chemotaxis protein I, serine sensor receptor path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 299.0 59.0 49.0 2.0 0.855072463768116 NT 0.0 69.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 69.0 0.0 1.0 0.0014174387948392 0.0034805833953661 0.0024490110951026 0.0020631446005269 0 0 0 0 K05875 0.0 0.0541310541310541 tar; methyl-accepting chemotaxis protein II, aspartate sensor receptor path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 216.0 38.0 28.0 2.0 0.791666666666667 NT 0.0 48.0 2.0 0.979166666666667 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 48.0 0.0 1.0 0.0016339229211941 0.003808640170617 0.0027212815459055 0.0021747172494229 0 0 0 0 K05876 0.0 0.0113960113960113 trg; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 486.0 7.0 3.0 2.0 0.636363636363636 NT 0.0 11.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 11.0 0.0 1.0 0.0052312575991148 0.0081080639428691 0.0066696607709919 0.0028768063437542 0 0 0 0 K05877 0.0 0.0085470085470085 tap; methyl-accepting chemotaxis protein IV, peptide sensor receptor path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 484.0 13.0 0.0 1.0 1.0 NT 0.0 13.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 13.0 0.0 1.0 2.08318454672027e-06 4.42272833508138e-12 1.0415944847243023e-06 2.083180123991935e-06 0 0 0 0 K05878 0.0428571428571428 0.1851851851851851 dhaK; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 305.0 100.0 99.0 2.0 0.99009900990099 G 15.0 86.0 2.0 0.97029702970297 COG2376 Dihydroxyacetone_kinase DAK1 101.0 0.1485148514851485 0.8514851485148515 0.0063506186909159 0.566782853186348 0.2865667359386319 0.5604322344954321 0 0 0 0 K05879 0.0428571428571428 0.1481481481481481 dhaL; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 172.0 53.0 31.0 3.0 0.67948717948718 S 15.0 63.0 3.0 0.782051282051282 COG1461 Predicted_kinase_related_to_dihydroxyacetone_kinase YloV 78.0 0.1923076923076923 0.8076923076923077 0.0073668279895637 0.868583719563127 0.4379752737763453 0.8612168915735633 0 0 0 0 K05880 0.0 0.0056980056980056 dhaR; transcriptional activator for dhaKLM operon 83.0 2.0 0.0 1.0 1.0 KQ 0.0 2.0 1.0 1.0 COG3284 Transcriptional_regulator_DhaR_of_acetoin/glycerol_metabolism AcoR 2.0 0.0 1.0 0 0 0 0 K05881 0.0428571428571428 0.0997150997150997 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 106.0 36.0 16.0 2.0 0.642857142857143 G 15.0 35.0 3.0 0.714285714285714 COG3412 Phosphotransferase_subunit_DhaM_of_the_dihydroxyacetone_kinase_DhaKLM_complex,_contains_PTS-EIIA,_HPr,_and_PEP-utilizing_domains DhaM 50.0 0.3 0.7 0.0159777664010692 0.38634989181408 0.2011638291075746 0.3703721254130108 0 0 0 0 K05882 0.0028571428571428 0.0826210826210826 E1.1.1.91; aryl-alcohol dehydrogenase (NADP+) [EC:1.1.1.91] 262.0 50.0 0.0 1.0 1.0 C 1.0 49.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 50.0 0.02 0.98 0.006564547217109 0.0095126747504354 0.0080386109837722 0.0029481275333264 0 0 0 0 K05884 0.0514285714285714 0.0028490028490028 comC; L-2-hydroxycarboxylate dehydrogenase (NAD+) [EC:1.1.1.337] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 332.0 20.0 0.0 1.0 1.0 C 18.0 2.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 20.0 0.9 0.1 0.0053880292787166 0.0039511288924804 0.0046695790855985 0.0014369003862361 0 0 0 0 K05886 0.0 0.0541310541310541 sdh; serine 3-dehydrogenase (NADP+) [EC:1.1.1.276] 224.0 17.0 15.0 2.0 0.894736842105263 S 0.0 19.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 19.0 0.0 1.0 0.0086874574741614 0.0246360955634058 0.0166617765187836 0.0159486380892444 0 0 0 0 K05887 0.0 0.0056980056980056 ydiB; quinate/shikimate dehydrogenase [EC:1.1.1.282] path:map00400,path:map01100,path:map01110 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 274.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0169 Shikimate_5-dehydrogenase AroE 2.0 0.0 1.0 0 0 0 0 K05889 0.0171428571428571 0.0398860398860398 pvadh; polyvinyl alcohol dehydrogenase (cytochrome) [EC:1.1.2.6] 74.0 20.0 5.0 5.0 0.487804878048781 O 18.0 20.0 5.0 0.829268292682927 COG1520 Outer_membrane_protein_assembly_factor_BamB,_contains_PQQ-like_beta-propeller_repeat PQQ 38.0 0.4736842105263157 0.5263157894736842 0.0050290638703696 0.0121199093741249 0.0085744866222472 0.0070908455037553 0 0 0 0 K05895 0.0514285714285714 0.2421652421652421 cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 137.0 103.0 98.0 2.0 0.953703703703704 H 19.0 89.0 2.0 0.972222222222222 COG2099 Precorrin-6x_reductase CobK 108.0 0.1759259259259259 0.8240740740740741 0.0021475740258022 0.0371331510905003 0.0196403625581512 0.0349855770646981 0 0 0 0 K05896 0.7 0.7378917378917379 scpA; segregation and condensation protein A 51.0 263.0 17.0 3.0 0.513671875 D 249.0 264.0 3.0 0.992202729044834 COG1354 Chromatin_segregation_and_condensation_protein_Rec8/ScpA/Scc1,_kleisin_family ScpA 513.0 0.4853801169590643 0.5146198830409356 0.0282606957843918 0.0540555063026901 0.0411581010435409 0.0257948105182982 0 0 0 0 K05898 0.0057142857142857 0.0484330484330484 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 472.0 23.0 0.0 1.0 1.0 C 2.0 21.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 23.0 0.0869565217391304 0.9130434782608696 0.0307956881304113 0.0470468805179439 0.0389212843241776 0.0162511923875326 0 0 0 0 K05901 0.0 0.0028490028490028 BLVRB; biliverdin reductase / flavin reductase [EC:1.3.1.24 1.5.1.30] path:map00740,path:map00860,path:map01100,path:map01110 Riboflavin metabolism,Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 183.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2A5J3 1.0 0.0 1.0 0 0 0 0 K05906 0.0028571428571428 0.0 PCYOX1, FCLY; prenylcysteine oxidase / farnesylcysteine lyase [EC:1.8.3.5 1.8.3.6] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 441.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2CMX8 1.0 1.0 0.0 0 0 0 0 K05910 0.0 0.0142450142450142 npr; NADH peroxidase [EC:1.11.1.1] 442.0 4.0 2.0 3.0 0.571428571428571 C 0.0 7.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 7.0 0.0 1.0 0.0082592473523394 0.0175898065279759 0.0129245269401576 0.0093305591756364 0 0 0 0 K05913 0.0057142857142857 0.0113960113960113 dad; 2,4'-dihydroxyacetophenone dioxygenase [EC:1.13.11.41] path:map00363,path:map01120 Bisphenol degradation,Microbial metabolism in diverse environments 70.0 5.0 3.0 2.0 0.714285714285714 L 2.0 5.0 1.0 1.0 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 7.0 0.2857142857142857 0.7142857142857143 0.152551747051041 0.287734290184095 0.220143018617568 0.135182543133054 0 0 0 0 K05916 0.0 0.0 hmp, YHB1; nitric oxide dioxygenase [EC:1.14.12.17] 77.0 75.0 2.0 0.974683544303797 C 0.0 0.0 4.0 0.746835443037975 COG1017 Hemoglobin-like_flavoprotein Hmp 0.0 0 0 0 0 K05917 0.0028571428571428 0.0085470085470085 CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 61.0 4.0 3.0 2.0 0.8 C 1.0 4.0 2.0 0.6 COG1141 Ferredoxin Fer 5.0 0.2 0.8 0.112568705580986 0.363141397975339 0.2378550517781625 0.250572692394353 0 0 0 0 K05919 0.3628571428571429 0.2279202279202279 dfx; superoxide reductase [EC:1.15.1.2] 52.0 243.0 0.0 1.0 1.0 C 146.0 90.0 3.0 0.97119341563786 COG2033 Desulfoferrodoxin,_superoxide_reductase-like_(SORL)_domain SORL 236.0 0.6186440677966102 0.3813559322033898 0.873892530917116 0.666339680882952 0.7701161059000341 0.207552850034164 1 1 1 1 K05921 0.0142857142857142 0.0398860398860398 hpaG; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:4.1.1.68 5.3.3.-] path:map00350,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 191.0 23.0 22.0 2.0 0.958333333333333 Q 5.0 19.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 24.0 0.2083333333333333 0.7916666666666666 0.0056100785177536 0.0249398496546314 0.0152749640861925 0.0193297711368778 0 0 0 0 K05922 0.0 0.0484330484330484 hydB; quinone-reactive Ni/Fe-hydrogenase large subunit [EC:1.12.5.1] 529.0 20.0 0.0 1.0 1.0 C 0.0 20.0 1.0 1.0 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 20.0 0.0 1.0 0.0261395848850652 0.0352184936221248 0.0306790392535949 0.0090789087370596 0 0 0 0 K05926 0.0 0.0056980056980056 nhs; 23S rRNA (adenosine1067-2'-O)-methyltransferase [EC:2.1.1.230] 238.0 2.0 0.0 1.0 1.0 J 0.0 2.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 2.0 0.0 1.0 0 0 0 0 K05927 0.0028571428571428 0.0598290598290598 hydA; quinone-reactive Ni/Fe-hydrogenase small subunit [EC:1.12.5.1] 251.0 24.0 20.0 3.0 0.8 C 1.0 29.0 5.0 0.633333333333333 COG1740 Ni,Fe-hydrogenase_I_small_subunit HyaA 30.0 0.0333333333333333 0.9666666666666668 0.0354232070571928 0.0613162709207753 0.048369738988984 0.0258930638635825 0 0 0 0 K05928 0.0171428571428571 0.0484330484330484 E2.1.1.95; tocopherol O-methyltransferase [EC:2.1.1.95] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 161.0 13.0 6.0 3.0 0.565217391304348 Q 6.0 17.0 2.0 0.608695652173913 COG0500 SAM-dependent_methyltransferase SmtA 23.0 0.2608695652173913 0.7391304347826086 0.0049822351729716 0.002165386790143 0.0035738109815573 0.0028168483828286 0 0 0 0 K05929 0.0 0.0085470085470085 E2.1.1.103, NMT; phosphoethanolamine N-methyltransferase [EC:2.1.1.103] path:map00564 Glycerophospholipid metabolism 174.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 2.0 0.666666666666667 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.0 1.0 0 0 0 0 K05934 0.2885714285714286 0.2393162393162393 cobJ, cbiH; precorrin-3B C17-methyltransferase / cobalt-factor III methyltransferase [EC:2.1.1.131 2.1.1.272] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 162.0 219.0 218.0 2.0 0.995454545454546 H 130.0 90.0 6.0 0.954545454545455 COG1010 Precorrin-3B_methylase CobJ 220.0 0.5909090909090909 0.4090909090909091 0.0048832253375241 0.0575796627763749 0.0312314440569494 0.0526964374388508 0 0 0 0 K05936 0.3 0.3247863247863248 cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 207.0 228.0 0.0 1.0 1.0 H 108.0 120.0 3.0 0.960526315789474 COG2875 Precorrin-4_methylase CobM 228.0 0.4736842105263157 0.5263157894736842 0.004053214110037 0.0283509795056781 0.0162020968078575 0.0242977653956411 0 0 0 0 K05937 0.0 0.0199430199430199 K05937; uncharacterized protein 122.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG5646 Iron-binding_protein_Fra/YdhG,_frataxin_family_(Fe-S_cluster_biosynthesis) Fra 7.0 0.0 1.0 0.0025409287306716 0.0141982418669653 0.0083695852988184 0.0116573131362937 0 0 0 0 K05939 0.0 0.0 aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20] path:map00071,path:map00564 Fatty acid degradation,Glycerophospholipid metabolism 29.0 8.0 5.0 0.475409836065574 I 0.0 0.0 4.0 0.60655737704918 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 0.0 0 0 0 0 K05946 0.0057142857142857 0.4558404558404558 tagA, tarA; N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase [EC:2.4.1.187] path:map00552 Teichoic acid biosynthesis 59.0 201.0 192.0 5.0 0.930555555555556 M 2.0 214.0 9.0 0.865740740740741 COG1922 UDP-N-acetyl-D-mannosaminuronic_acid_transferase,_WecB/TagA/CpsF_family WecG 216.0 0.0092592592592592 0.9907407407407408 0.936973956340794 0.951467320940496 0.944220638640645 0.014493364599702 0 0 1 1 K05947 0.0542857142857142 0.0199430199430199 E2.4.1.217; mannosyl-3-phosphoglycerate synthase [EC:2.4.1.217] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 361.0 13.0 1.0 4.0 0.448275862068966 G 22.0 7.0 2.0 0.931034482758621 COG3769 Mannosyl-3-phosphoglycerate_phosphatase_YedP/MpgP,_HAD_superfamily YedP 29.0 0.7586206896551724 0.2413793103448276 0.855234995182445 0.998971106981215 0.92710305108183 0.1437361117987701 1 1 1 1 K05951 0.0 0.0313390313390313 draT; NAD+---dinitrogen-reductase ADP-D-ribosyltransferase [EC:2.4.2.37] 263.0 12.0 0.0 1.0 1.0 H 0.0 12.0 1.0 1.0 28IJT 12.0 0.0 1.0 0.0534752022980399 0.141500032123491 0.0974876172107654 0.0880248298254511 0 0 0 0 K05952 0.0 0.0427350427350427 K05952; uncharacterized protein 51.0 10.0 4.0 2.0 0.625 S 0.0 16.0 1.0 1.0 COG2991 Na+-NQR_maturation_protein_NqrM NqrM 16.0 0.0 1.0 0.0125091519846528 0.0371200685076154 0.0248146102461341 0.0246109165229626 0 0 0 0 K05953 0.0028571428571428 0.0 NAS; nicotianamine synthase [EC:2.5.1.43] path:map00270,path:map00999,path:map01100,path:map01110 Cysteine and methionine metabolism,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 311.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 28MAT 1.0 1.0 0.0 0 0 0 0 K05956 0.0028571428571428 0.017094017094017 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60] 248.0 4.0 1.0 2.0 0.571428571428571 O 1.0 6.0 3.0 0.428571428571429 COG1689 Class_II_terpene_cyclase_family_protein_AF1543 AF1543 7.0 0.1428571428571428 0.8571428571428571 1.01358318369416e-11 1.872230914923909e-11 1.4429070493090344e-11 8.586477312297489e-12 0 0 0 0 K05962 0.0 0.0541310541310541 126.0 24.0 23.0 2.0 0.96 T 0.0 25.0 10.0 0.36 COG5002 Sensor_histidine_kinase_WalK WalK 25.0 0.0 1.0 0.0056397453409463 0.0449743050283919 0.0253070251846691 0.0393345596874456 0 0 0 0 K05964 0.0028571428571428 0.0341880341880341 citX; holo-ACP synthase [EC:2.7.7.61] path:map02020 Two-component system 136.0 9.0 5.0 3.0 0.642857142857143 HI 1.0 13.0 3.0 0.714285714285714 COG3697 Phosphoribosyl-dephospho-CoA_transferase_(holo-ACP_synthetase) CitX 14.0 0.0714285714285714 0.9285714285714286 0.119748731404035 0.53929740200644 0.3295230667052375 0.4195486706024051 0 0 0 0 K05966 0.4542857142857143 0.0626780626780626 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] path:map02020 Two-component system 161.0 186.0 185.0 3.0 0.98936170212766 H 164.0 24.0 2.0 0.99468085106383 COG1767 Triphosphoribosyl-dephospho-CoA_synthetase CitG 188.0 0.8723404255319149 0.1276595744680851 0.940172376657482 0.329315026350786 0.634743701504134 0.610857350306696 1 1 1 1 K05967 0.0828571428571428 0.0712250712250712 K05967; uncharacterized protein 34.0 57.0 51.0 2.0 0.904761904761905 S 33.0 30.0 5.0 0.507936507936508 COG5663 Uncharacterized_conserved_protein_YqfW,_HAD_superfamily YqfW 63.0 0.5238095238095238 0.4761904761904761 0.0059894726201444 0.280533453123022 0.1432614628715832 0.2745439805028776 0 0 0 0 K05970 0.0571428571428571 0.1481481481481481 SIAE; sialate O-acetylesterase [EC:3.1.1.53] 64.0 38.0 5.0 7.0 0.316666666666667 G 20.0 101.0 12.0 0.28099173553719 COG2755 Lysophospholipase_L1_or_related_esterase._Includes_spore_coat_protein_LipC/YcsK TesA 121.0 0.1652892561983471 0.8347107438016529 0.591299584969645 0.210259626370114 0.4007796056698794 0.381039958599531 0 1 0 1 K05972 0.0 0.0142450142450142 AXE1; acetylxylan esterase [EC:3.1.1.72] 304.0 5.0 0.0 1.0 1.0 Q 0.0 5.0 1.0 1.0 COG3509 Acetyl_xylan_esterase_AxeA_and_related_esterases,_LpqC_family LpqC 5.0 0.0 1.0 4.5773799404243e-07 5.03837963902537e-05 2.5420767192148064e-05 4.992605839621127e-05 0 0 0 0 K05973 0.0057142857142857 0.0854700854700854 phaZ; poly(3-hydroxybutyrate) depolymerase [EC:3.1.1.75] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 346.0 38.0 36.0 3.0 0.926829268292683 I 2.0 39.0 3.0 0.926829268292683 COG4553 Poly-beta-hydroxyalkanoate_depolymerase DepA 41.0 0.048780487804878 0.951219512195122 0.0026834484772001 0.0087413585941373 0.0057124035356687 0.0060579101169371 0 0 0 0 K05977 0.0 0.0056980056980056 dszB; 2'-hydroxybiphenyl-2-sulfinate desulfinase [EC:3.13.1.3] 270.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 3.0 0.0 1.0 0 0 0 0 K05978 0.0 0.0085470085470085 stpA; glucosylglycerol 3-phosphatase [EC:3.1.3.69] 393.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 28IUG 3.0 0.0 1.0 0 0 0 0 K05979 0.1371428571428571 0.2336182336182336 comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 98.0 139.0 0.0 1.0 1.0 H 50.0 89.0 1.0 1.0 COG2045 Phosphosulfolactate_phosphohydrolase_or_related_enzyme ComB 139.0 0.3597122302158273 0.6402877697841727 0.928618885723465 0.722177782801665 0.825398334262565 0.2064411029217999 1 1 1 1 K05982 0.5457142857142857 0.2136752136752136 E3.1.21.7, nfi; deoxyribonuclease V [EC:3.1.21.7] 106.0 276.0 0.0 1.0 1.0 L 197.0 78.0 4.0 0.88768115942029 COG1515 Deoxyinosine_3'-endonuclease_(endonuclease_V) Nfi 275.0 0.7163636363636363 0.2836363636363636 0.118117595080611 0.659234091051756 0.3886758430661835 0.541116495971145 0 0 0 0 K05984 0.0 0.0113960113960113 cho; excinuclease Cho [EC:3.1.25.-] 56.0 4.0 0.0 1.0 1.0 L 0.0 4.0 1.0 1.0 COG0322 Excinuclease_UvrABC,_nuclease_subunit UvrC 4.0 0.0 1.0 0.102621631841694 0.194222566552029 0.1484220991968615 0.091600934710335 0 0 0 0 K05985 0.0085714285714285 0.131054131054131 rnmV; ribonuclease M5 [EC:3.1.26.8] 145.0 34.0 19.0 2.0 0.693877551020408 J 3.0 46.0 2.0 0.979591836734694 COG1658 5S_rRNA_maturation_ribonuclease_M5,_contains_TOPRIM_domain RnmV 49.0 0.0612244897959183 0.9387755102040816 0.0214832596500385 0.016768498857409 0.0191258792537237 0.0047147607926294 0 0 0 0 K05986 0.0 0.0113960113960113 NUCS; nuclease S1 [EC:3.1.30.1] 256.0 4.0 3.0 2.0 0.8 S 0.0 5.0 1.0 1.0 28JIP 5.0 0.0 1.0 5.0930475908994286e-12 0.0895135781797792 0.0447567890924361 0.0895135781746861 0 0 0 0 K05988 0.0 0.0 dexA; dextranase [EC:3.2.1.11] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 20.0 4.0 3.0 0.487804878048781 G 0.0 0.0 9.0 0.487804878048781 COG1649 Uncharacterized_lipoprotein_YddW,_UPF0748_family YddW 0.0 0 0 0 0 K05989 0.04 0.1282051282051282 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] 341.0 98.0 90.0 3.0 0.91588785046729 G 16.0 91.0 10.0 0.420560747663551 COG3408 Glycogen_debranching_enzyme_(alpha-1,6-glucosidase) GDB1 107.0 0.1495327102803738 0.8504672897196262 0.0221738255547569 0.212599940756386 0.1173868831555714 0.1904261152016291 0 0 0 0 K05991 0.0142857142857142 0.0284900284900284 E3.2.1.123; endoglycosylceramidase [EC:3.2.1.123] 256.0 14.0 11.0 2.0 0.823529411764706 G 5.0 12.0 2.0 0.941176470588235 COG2730 Aryl-phospho-beta-D-glucosidase_BglC,_GH1_family BglC 17.0 0.2941176470588235 0.7058823529411765 0.140305287261811 0.13546247938887 0.1378838833253405 0.004842807872941 0 0 0 0 K05994 0.0114285714285714 0.0484330484330484 E3.4.11.10; bacterial leucyl aminopeptidase [EC:3.4.11.10] 165.0 21.0 18.0 4.0 0.75 S 6.0 22.0 4.0 0.892857142857143 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 28.0 0.2142857142857142 0.7857142857142857 0.0069978511892908 0.0287558553245215 0.0178768532569061 0.0217580041352307 0 0 0 0 K05995 0.04 0.1396011396011396 pepE; dipeptidase E [EC:3.4.13.21] 83.0 67.0 65.0 3.0 0.957142857142857 E 14.0 56.0 3.0 0.957142857142857 COG3340 Peptidase_E PepE 70.0 0.2 0.8 0.0410151850058482 0.966828226372033 0.5039217056889406 0.9258130413661848 0 0 0 0 K05996 0.06 0.0883190883190883 cpt; carboxypeptidase T [EC:3.4.17.18] 93.0 40.0 23.0 6.0 0.547945205479452 E 25.0 46.0 2.0 0.73972602739726 COG2866 Murein_tripeptide_amidase_MpaA MpaA 71.0 0.352112676056338 0.647887323943662 0.757634142695066 0.989954315466428 0.873794229080747 0.2323201727713619 1 1 1 1 K05997 0.0 0.037037037037037 sufA; Fe-S cluster assembly protein SufA 105.0 14.0 13.0 2.0 0.933333333333333 S 0.0 15.0 1.0 1.0 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 15.0 0.0 1.0 0.0036241869591693 0.0108551393090934 0.0072396631341313 0.0072309523499241 0 0 0 0 K05999 0.0 0.0028490028490028 E3.4.21.101; xanthomonalisin [EC:3.4.21.101] 595.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG4733 Phage-related_protein,_tail_protein_J 1.0 0.0 1.0 0 0 0 0 K06001 0.3885714285714285 0.3076923076923077 trpB; tryptophan synthase beta chain [EC:4.2.1.20] path:map00260,path:map00400,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 400.0 279.0 0.0 1.0 1.0 E 154.0 125.0 2.0 0.849462365591398 COG1350 Predicted_alternative_tryptophan_synthase_beta-subunit_(paralog_of_TrpB) 279.0 0.5519713261648745 0.4480286738351254 0.906888399315387 0.952697674664964 0.9297930369901756 0.045809275349577 1 1 1 1 K06006 0.0 0.0541310541310541 cpxP, spy; periplasmic protein CpxP/Spy 83.0 22.0 0.0 1.0 1.0 NPTU 0.0 23.0 2.0 0.956521739130435 COG3678 Periplasmic_chaperone_Spy,_Spy/CpxP_family CpxP 23.0 0.0 1.0 0 0 0 0 K06012 0.0 0.0826210826210826 gpr; spore protease [EC:3.4.24.78] 274.0 28.0 27.0 2.0 0.96551724137931 C 0.0 29.0 1.0 1.0 COG0680 Ni,Fe-hydrogenase_maturation_factor HyaD 29.0 0.0 1.0 0.0095749518968494 0.0212493388738809 0.0154121453853651 0.0116743869770315 0 0 0 0 K06013 0.12 0.2849002849002849 STE24; STE24 endopeptidase [EC:3.4.24.84] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 125.0 149.0 145.0 3.0 0.961290322580645 O 47.0 107.0 2.0 0.974193548387097 COG0501 Zn-dependent_protease_with_chaperone_function HtpX 154.0 0.3051948051948052 0.6948051948051948 0.755145651667313 0.799744016550141 0.777444834108727 0.044598364882828 1 1 1 1 K06015 0.06 0.1937321937321937 E3.5.1.81; N-acyl-D-amino-acid deacylase [EC:3.5.1.81] 308.0 143.0 138.0 2.0 0.966216216216216 Q 42.0 106.0 2.0 0.966216216216216 COG3653 N-acyl-D-aspartate/D-glutamate_deacylase 148.0 0.2837837837837837 0.7162162162162162 0.0096040411713813 0.0771013771346988 0.04335270915304 0.0674973359633175 0 0 0 0 K06016 0.0942857142857142 0.2279202279202279 pydC; beta-ureidopropionase / N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 242.0 163.0 162.0 3.0 0.987878787878788 E 51.0 114.0 3.0 0.975757575757576 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 165.0 0.3090909090909091 0.6909090909090909 0.0813123001252471 0.356215412500164 0.2187638563127055 0.2749031123749169 0 0 0 0 K06019 0.1714285714285714 0.1225071225071225 ppaX; pyrophosphatase PpaX [EC:3.6.1.1] path:map00190 Oxidative phosphorylation 72.0 94.0 74.0 4.0 0.764227642276423 S 75.0 48.0 1.0 1.0 COG0546 Phosphoglycolate_phosphatase,_HAD_superfamily Gph 123.0 0.6097560975609756 0.3902439024390244 0.884105479036102 0.970182946559228 0.927144212797665 0.0860774675231259 1 1 1 1 K06020 0.0028571428571428 0.131054131054131 ettA; energy-dependent translational throttle protein EttA 513.0 37.0 31.0 5.0 0.711538461538462 S 1.0 51.0 4.0 0.788461538461538 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 52.0 0.0192307692307692 0.9807692307692308 0.0094476948476103 0.26126388527465 0.1353557900611301 0.2518161904270397 0 0 0 0 K06021 0.0 0.0085470085470085 367.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 3.0 0.0 1.0 0 0 0 0 K06022 0.0 0.037037037037037 530.0 12.0 10.0 2.0 0.857142857142857 S 0.0 14.0 1.0 1.0 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 14.0 0.0 1.0 0.0123135289941793 0.0226068919376516 0.0174602104659154 0.0102933629434722 0 0 0 0 K06023 0.0028571428571428 0.358974358974359 hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-] 171.0 64.0 27.0 3.0 0.481203007518797 T 1.0 132.0 1.0 1.0 COG1493 Serine_kinase_of_the_HPr_protein,_regulates_carbohydrate_metabolism HprK 133.0 0.0075187969924812 0.9924812030075189 0.0007903809286042 0.0236632480355276 0.0122268144820659 0.0228728671069234 0 0 0 0 K06024 0.6 0.7378917378917379 scpB; segregation and condensation protein B 74.0 272.0 76.0 2.0 0.581196581196581 D 214.0 264.0 2.0 0.97907949790795 COG1386 Chromosome_segregation_and_condensation_protein_ScpB ScpB 478.0 0.4476987447698745 0.5523012552301255 0.916306308861226 0.777671478344496 0.846988893602861 0.1386348305167299 1 1 1 1 K06027 0.0028571428571428 0.074074074074074 NSF, SEC18; vesicle-fusing ATPase [EC:3.6.4.6] path:map04138,path:map04721,path:map04727,path:map04962 Autophagy - yeast,Synaptic vesicle cycle,GABAergic synapse,Vasopressin-regulated water reabsorption 251.0 26.0 25.0 2.0 0.962962962962963 O 1.0 26.0 3.0 0.555555555555556 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 27.0 0.037037037037037 0.9629629629629628 0.945886022974806 0.204890264211839 0.5753881435933225 0.740995758762967 0 0 1 1 K06030 0.0 0.0028490028490028 MFN2, FZO1; mitofusin 2 [EC:3.6.5.-] path:map04137,path:map04214,path:map04621,path:map05012,path:map05022 Mitophagy - animal,Apoptosis - fly,NOD-like receptor signaling pathway,Parkinson disease,Pathways of neurodegeneration - multiple diseases 169.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0699 Replication_fork_clamp-binding_protein_CrfC_(dynamin-like_GTPase_family) CrfC 1.0 0.0 1.0 0 0 0 0 K06033 0.0 0.0028490028490028 E4.1.1.76; arylmalonate decarboxylase [EC:4.1.1.76] 268.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3473 Maleate_cis-trans_isomerase 1.0 0.0 1.0 0 0 0 0 K06034 0.0714285714285714 0.0256410256410256 comD; sulfopyruvate decarboxylase subunit alpha [EC:4.1.1.79] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 131.0 33.0 32.0 3.0 0.942857142857143 S 25.0 10.0 1.0 1.0 COG4032 Sulfopyruvate_decarboxylase,_TPP-binding_subunit_(coenzyme_M_biosynthesis) 35.0 0.7142857142857143 0.2857142857142857 0.020881499645844 0.0501015090849328 0.0354915043653884 0.0292200094390887 0 0 0 0 K06039 0.1171428571428571 0.1538461538461538 ychN; uncharacterized protein involved in oxidation of intracellular sulfur 59.0 96.0 91.0 2.0 0.95049504950495 P 47.0 61.0 2.0 0.888888888888889 COG1553 Sulfur_relay_(sulfurtransferase)_complex_TusBCD_TusD_component,_DsrE_family DsrE 108.0 0.4351851851851852 0.5648148148148148 0.840404522691536 0.420737248494486 0.630570885593011 0.4196672741970499 1 1 1 1 K06041 0.0142857142857142 0.5299145299145299 kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 240.0 195.0 190.0 5.0 0.951219512195122 M 5.0 200.0 4.0 0.902439024390244 COG0517 CBS_domain CBS 205.0 0.024390243902439 0.975609756097561 0.0083077652092624 0.0742589933885424 0.0412833792989024 0.06595122817928 0 0 0 0 K06042 0.3028571428571429 0.3219373219373219 cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 93.0 235.0 220.0 7.0 0.880149812734082 H 129.0 138.0 5.0 0.861423220973783 COG2082 Precorrin-8X_methylmutase_CbiC/CobH CobH 267.0 0.4831460674157303 0.5168539325842697 0.0780585830597617 0.0833902921907521 0.0807244376252569 0.0053317091309904 0 0 0 0 K06044 0.0342857142857142 0.1908831908831909 treY, glgY; (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase [EC:5.4.99.15] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 263.0 98.0 0.0 1.0 1.0 G 15.0 74.0 4.0 0.663265306122449 COG3280 Maltooligosyltrehalose_synthase TreY 89.0 0.1685393258426966 0.8314606741573034 0.0081349052652302 0.133066642409812 0.0706007738375211 0.1249317371445818 0 0 0 0 K06045 0.0314285714285714 0.150997150997151 shc; squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129] path:map00909,path:map01110 Sesquiterpenoid and triterpenoid biosynthesis,Biosynthesis of secondary metabolites 107.0 82.0 76.0 3.0 0.921348314606742 I 11.0 78.0 4.0 0.932584269662921 COG1657 Terpene_cyclase_SqhC SqhC 89.0 0.1235955056179775 0.8764044943820225 0.0102092300028529 0.285539930950869 0.1478745804768609 0.2753307009480161 0 0 0 0 K06046 0.0028571428571428 0.0142450142450142 luxE; long-chain-fatty-acid---luciferin-component ligase [EC:6.2.1.19] path:map02020,path:map02024 Two-component system,Quorum sensing 332.0 6.0 0.0 1.0 1.0 H 1.0 5.0 1.0 1.0 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 6.0 0.1666666666666666 0.8333333333333334 0.12673980339996 0.276986306754488 0.201863055077224 0.150246503354528 0 0 0 0 K06048 0.1542857142857142 0.2279202279202279 gshA, ybdK; glutamate---cysteine ligase / carboxylate-amine ligase [EC:6.3.2.2 6.3.-.-] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 151.0 88.0 3.0 4.0 0.49438202247191 S 54.0 124.0 4.0 0.887640449438202 COG2170 Gamma-glutamyl:cysteine_ligase_YbdK,_ATP-grasp_superfamily YbdK 178.0 0.3033707865168539 0.6966292134831461 0.0009757664005116 0.142143021481328 0.0715593939409198 0.1411672550808164 0 0 0 0 K06049 0.0 0.0313390313390313 bchO; magnesium chelatase accessory protein 282.0 12.0 0.0 1.0 1.0 I 0.0 12.0 1.0 1.0 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 12.0 0.0 1.0 0.0167009605865179 0.0530078965365558 0.0348544285615368 0.0363069359500378 0 0 0 0 K06072 0.0685714285714285 0.0 DOHH; deoxyhypusine monooxygenase [EC:1.14.99.29] 145.0 25.0 24.0 2.0 0.961538461538462 C 26.0 0.0 2.0 0.576923076923077 arCOG04006 26.0 1.0 0.0 1.38968714563187e-06 4.29274352520673e-12 6.948457191876976e-07 1.3896828528883447e-06 0 0 0 0 K06073 0.0 0.017094017094017 btuC; vitamin B12 transport system permease protein path:map02010 ABC transporters 301.0 4.0 3.0 3.0 0.666666666666667 P 0.0 6.0 2.0 0.666666666666667 COG0609 ABC-type_Fe3+-siderophore_transport_system,_permease_component FepD 6.0 0.0 1.0 0.0709863636669251 0.153183302220242 0.1120848329435835 0.0821969385533169 0 0 0 0 K06074 0.0 0.0113960113960113 btuD; vitamin B12 transport system ATP-binding protein [EC:7.6.2.8] path:map02010 ABC transporters 231.0 4.0 0.0 1.0 1.0 P 0.0 4.0 2.0 0.5 COG4138 ABC-type_cobalamin_transport_system,_ATPase_component_BtuD BtuD 4.0 0.0 1.0 5.7192762928638e-07 2.74517819867792e-05 1.401185480803279e-05 2.6879854357492818e-05 0 0 0 0 K06075 0.0057142857142857 0.1282051282051282 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin 70.0 64.0 0.0 1.0 1.0 K 2.0 62.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 64.0 0.03125 0.96875 0.0082976828096193 0.0360905433069229 0.022194113058271 0.0277928604973036 0 0 0 0 K06076 0.0 0.3276353276353276 fadL; long-chain fatty acid transport protein 78.0 152.0 151.0 2.0 0.993464052287582 I 0.0 153.0 1.0 1.0 COG2067 Long-chain_fatty_acid_transport_protein FadL 153.0 0.0 1.0 0.0017702826208059 0.230169795017675 0.1159700388192404 0.2283995123968691 0 0 0 0 K06077 0.0 0.0512820512820512 slyB; outer membrane lipoprotein SlyB 135.0 18.0 0.0 1.0 1.0 M 0.0 18.0 1.0 1.0 COG3133 Outer_membrane_lipoprotein_SlyB SlyB 18.0 0.0 1.0 0.0161209615309294 0.0313671492212437 0.0237440553760865 0.0152461876903143 0 0 0 0 K06078 0.0 0.0113960113960113 lpp; murein lipoprotein 74.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG4238 Outer_membrane_murein-binding_lipoprotein_Lpp Lpp 5.0 0.0 1.0 9.63767132887669e-11 3.2269971070794e-09 1.6616869101840832e-09 3.130620393790633e-09 0 0 0 0 K06079 0.0 0.0227920227920227 cutF, nlpE; copper homeostasis protein (lipoprotein) path:map01503 Cationic antimicrobial peptide (CAMP) resistance 37.0 6.0 5.0 3.0 0.75 MP 0.0 8.0 2.0 0.875 COG3015 Uncharacterized_lipoprotein_NlpE_involved_in_copper_resistance CutF 8.0 0.0 1.0 0.0431882355421723 0.0917926551376661 0.0674904453399192 0.0486044195954938 0 0 0 0 K06080 0.0 0.0142450142450142 rcsF; RcsF protein path:map02020 Two-component system 116.0 3.0 2.0 2.0 0.75 M 0.0 5.0 3.0 0.6 2B4JI 5.0 0.0 1.0 9.77853534128947e-12 8.88945589578728e-11 4.933654714958113e-11 7.911602361658333e-11 0 0 0 0 K06108 0.0142857142857142 0.0 RAB3B; Ras-related protein Rab-3B 168.0 6.0 0.0 1.0 1.0 U 6.0 0.0 2.0 0.833333333333333 KOG0093 6.0 1.0 0.0 0.335481658643028 0.758098805613856 0.546790232128442 0.422617146970828 0 0 0 0 K06109 0.0228571428571428 0.0 RAB13; Ras-related protein Rab-13 path:map04530 Tight junction 160.0 8.0 7.0 2.0 0.888888888888889 U 9.0 0.0 1.0 1.0 KOG0078 9.0 1.0 0.0 0.780785899196708 0.945984889843399 0.8633853945200536 0.1651989906466909 0 0 1 1 K06113 0.0114285714285714 0.1054131054131054 abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] 111.0 60.0 57.0 5.0 0.869565217391304 G 4.0 65.0 6.0 0.782608695652174 COG3507 Beta-xylosidase XynB2 69.0 0.0579710144927536 0.9420289855072465 0.266792395552132 0.0716189075195134 0.1692056515358227 0.1951734880326186 0 0 0 0 K06118 0.0028571428571428 0.0712250712250712 SQD1, sqdB; UDP-sulfoquinovose synthase [EC:3.13.1.1] path:map00520,path:map00561,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Glycerolipid metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 371.0 25.0 24.0 2.0 0.961538461538462 GM 1.0 25.0 2.0 0.961538461538462 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 26.0 0.0384615384615384 0.9615384615384616 0.0437230458788428 0.518932242813711 0.2813276443462769 0.4752091969348682 0 0 0 0 K06120 0.0 0.0056980056980056 dhaB; glycerol dehydratase large subunit [EC:4.2.1.30] path:map00561 Glycerolipid metabolism 554.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG4909 Propanediol_dehydratase,_large_subunit PduC 2.0 0.0 1.0 0 0 0 0 K06121 0.0 0.0056980056980056 dhbC; glycerol dehydratase medium subunit [EC:4.2.1.30] path:map00561 Glycerolipid metabolism 214.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG4909 Propanediol_dehydratase,_large_subunit PduC 2.0 0.0 1.0 0 0 0 0 K06122 0.0 0.0056980056980056 dhbE; glycerol dehydratase small subunit [EC:4.2.1.30] path:map00561 Glycerolipid metabolism 168.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG4910 Propanediol_dehydratase,_small_subunit PduE 2.0 0.0 1.0 0 0 0 0 K06125 0.0 0.0626780626780626 COQ2; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 273.0 22.0 0.0 1.0 1.0 H 0.0 22.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 22.0 0.0 1.0 0.0023318342185239 0.0052314554514387 0.0037816448349813 0.0028996212329148 0 0 0 0 K06127 0.0028571428571428 0.0 COQ5; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.201] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 255.0 1.0 0.0 1.0 1.0 H 1.0 0.0 1.0 1.0 COG2226 Ubiquinone/menaquinone_biosynthesis_C-methylase_UbiE/MenG UbiE 1.0 1.0 0.0 0 0 0 0 K06128 0.0028571428571428 0.0 LYPLA1; lysophospholipase I [EC:3.1.1.5] path:map00564,path:map05231 Glycerophospholipid metabolism,Choline metabolism in cancer 200.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG0400 Predicted_esterase YpfH 1.0 1.0 0.0 0 0 0 0 K06130 0.0028571428571428 0.0 LYPLA2; lysophospholipase II [EC:3.1.1.5] path:map00564 Glycerophospholipid metabolism 200.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG0400 Predicted_esterase YpfH 1.0 1.0 0.0 0 0 0 0 K06131 0.1371428571428571 0.4643874643874643 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 73.0 293.0 288.0 3.0 0.976666666666667 I 56.0 243.0 1.0 1.0 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin_synthase Cls 299.0 0.1872909698996655 0.8127090301003345 0.0136478317995359 0.0609361769183329 0.0372920043589344 0.0472883451187969 0 0 0 0 K06132 0.0371428571428571 0.0569800569800569 clsC; cardiolipin synthase C [EC:2.7.8.-] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 136.0 40.0 0.0 1.0 1.0 I 14.0 26.0 1.0 1.0 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin_synthase Cls 40.0 0.35 0.65 0.0094907019496841 0.0672416791074939 0.038366190528589 0.0577509771578098 0 0 0 0 K06133 0.0257142857142857 0.2905982905982906 LYS5, acpT; 4'-phosphopantetheinyl transferase [EC:2.7.8.-] path:map00770,path:map01100 Pantothenate and CoA biosynthesis,Metabolic pathways 54.0 121.0 115.0 3.0 0.923664122137405 H 9.0 122.0 3.0 0.923664122137405 COG2091 Phosphopantetheinyl_transferase Sfp 131.0 0.0687022900763358 0.931297709923664 0.01209407003031 0.103408893322788 0.057751481676549 0.091314823292478 0 0 0 0 K06134 0.0 0.0968660968660968 COQ7; 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 153.0 34.0 0.0 1.0 1.0 H 0.0 34.0 1.0 1.0 COG2941 Demethoxyubiquinone_hydroxylase,_CLK1/Coq7/Cat5_family_(ubiquinone_biosynthesis) Coq7 34.0 0.0 1.0 0.0037380184640876 0.0106306790591695 0.0071843487616285 0.0068926605950819 0 0 0 0 K06135 0.0 0.0056980056980056 pqqA; pyrroloquinoline quinone biosynthesis protein A 32.0 1.0 0.0 2.0 0.5 S 0.0 2.0 2.0 0.5 2AQRV 2.0 0.0 1.0 0 0 0 0 K06136 0.0742857142857142 0.0997150997150997 pqqB; pyrroloquinoline quinone biosynthesis protein B 174.0 55.0 46.0 4.0 0.797101449275362 S 26.0 43.0 3.0 0.884057971014493 COG1235 Phosphoribosyl_1,2-cyclic_phosphate_phosphodiesterase PhnP 69.0 0.3768115942028985 0.6231884057971014 0.0126823409573135 0.211227645841571 0.1119549933994422 0.1985453048842575 0 0 0 0 K06137 0.0971428571428571 0.1367521367521367 pqqC; pyrroloquinoline-quinone synthase [EC:1.3.3.11] 90.0 85.0 75.0 3.0 0.841584158415841 H 41.0 60.0 3.0 0.841584158415842 COG5424 Pyrroloquinoline_quinone_(PQQ)_biosynthesis_protein_C PqqC 101.0 0.4059405940594059 0.594059405940594 0.0016914917478312 0.0042063836447719 0.0029489376963015 0.0025148918969407 0 0 0 0 K06138 0.0 0.0968660968660968 pqqD; pyrroloquinoline quinone biosynthesis protein D 58.0 27.0 20.0 3.0 0.675 S 0.0 40.0 3.0 0.525 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 40.0 0.0 1.0 0.0043996276040857 0.0812706641078295 0.0428351458559576 0.0768710365037438 0 0 0 0 K06139 0.0657142857142857 0.1367521367521367 pqqE; PqqA peptide cyclase [EC:1.21.98.4] 105.0 38.0 18.0 4.0 0.463414634146341 S 29.0 53.0 3.0 0.975609756097561 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 82.0 0.3536585365853658 0.6463414634146342 0.917368378607158 0.491441536596893 0.7044049576020255 0.425926842010265 1 1 1 1 K06140 0.0 0.1282051282051282 rnk; regulator of nucleoside diphosphate kinase 92.0 40.0 24.0 2.0 0.714285714285714 K 0.0 56.0 2.0 0.964285714285714 COG0782 Transcription_elongation_factor,_GreA/GreB_family GreA 56.0 0.0 1.0 0.0021711864204977 0.0044074834582965 0.003289334939397 0.0022362970377988 0 0 0 0 K06141 0.0 0.0113960113960113 tsgA; MFS transporter, TsgA protein 366.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG0738 Fucose_permease FucP 4.0 0.0 1.0 0.0618063269199272 0.144165586065793 0.1029859564928601 0.0823592591458658 0 0 0 0 K06142 0.0 0.4301994301994302 hlpA, ompH; outer membrane protein 30.0 227.0 0.0 1.0 1.0 M 0.0 227.0 1.0 1.0 COG2825 Periplasmic_chaperone_for_outer_membrane_proteins,_Skp_family HlpA 227.0 0.0 1.0 0.0209685590007977 0.277903866177471 0.1494362125891343 0.2569353071766733 0 0 0 0 K06143 0.0 0.0769230769230769 creD; inner membrane protein 336.0 27.0 0.0 1.0 1.0 V 0.0 27.0 1.0 1.0 COG4452 Inner_membrane_protein_CreD_involved_in_colicin_E2_resistance CreD 27.0 0.0 1.0 0.0101041977408618 0.0218372028165863 0.015970700278724 0.0117330050757244 0 0 0 0 K06144 0.0 0.0113960113960113 uspB; universal stress protein B 109.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 291H9 4.0 0.0 1.0 2.2683504205928e-12 2.25427647284005e-08 1.1272516539410546e-08 2.2540496377979908e-08 0 0 0 0 K06145 0.0 0.0797720797720797 gntR; LacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor 299.0 43.0 0.0 1.0 1.0 K 0.0 43.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 43.0 0.0 1.0 0.0033309070775235 0.0092299930974803 0.0062804500875019 0.0058990860199568 0 0 0 0 K06146 0.0 0.0028490028490028 idnR, gntH; LacI family transcriptional regulator, gluconate utilization system Gnt-II transcriptional activator 332.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 1.0 0.0 1.0 0 0 0 0 K06147 0.4028571428571428 0.8518518518518519 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial 75.0 1571.0 1281.0 9.0 0.836528221512247 V 367.0 1501.0 13.0 0.906333155934007 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 1868.0 0.1964668094218415 0.8035331905781584 0 0 0 0 K06148 0.1 0.4700854700854701 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial 124.0 321.0 273.0 4.0 0.825192802056555 V 49.0 342.0 6.0 0.711734693877551 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 391.0 0.1253196930946291 0.8746803069053708 0.455678356358735 0.66264045813328 0.5591594072460075 0.206962101774545 0 0 0 0 K06149 0.0085714285714285 0.094017094017094 uspA; universal stress protein A 79.0 44.0 0.0 1.0 1.0 T 3.0 41.0 1.0 1.0 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 44.0 0.0681818181818181 0.9318181818181818 0.0025837092275774 0.0068942988613925 0.0047390040444849 0.004310589633815 0 0 0 0 K06151 0.0142857142857142 0.0398860398860398 E1.1.99.3A; gluconate 2-dehydrogenase alpha chain [EC:1.1.99.3] path:map00030,path:map01100,path:map01120 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments 480.0 24.0 23.0 2.0 0.96 E 5.0 20.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 25.0 0.2 0.8 0.0185727433226864 0.0550939026848713 0.0368333230037788 0.0365211593621849 0 0 0 0 K06152 0.0171428571428571 0.0341880341880341 E1.1.99.3G; gluconate 2-dehydrogenase gamma chain [EC:1.1.99.3] path:map00030,path:map01100,path:map01120 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments 145.0 20.0 19.0 2.0 0.952380952380952 S 6.0 15.0 3.0 0.666666666666667 2DB8V 21.0 0.2857142857142857 0.7142857142857143 0.0281391521699358 0.116198180186229 0.0721686661780824 0.0880590280162932 0 0 0 0 K06153 0.3828571428571428 0.9002849002849003 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] path:map00550,path:map00552 Peptidoglycan biosynthesis,Teichoic acid biosynthesis 105.0 371.0 257.0 3.0 0.760245901639344 V 138.0 350.0 2.0 0.993852459016393 COG1968 Undecaprenyl_pyrophosphate_phosphatase UppP 488.0 0.2827868852459016 0.7172131147540983 0.28976060397893 0.873632787474015 0.5816966957264724 0.583872183495085 0 0 0 0 K06154 0.1171428571428571 0.0 lysM; Lrp/AsnC family transcriptional regulator, involved in the regulation of lysine biosynthesis 125.0 43.0 0.0 1.0 1.0 K 43.0 0.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 43.0 1.0 0.0 0.0500942164331887 0.898759901071334 0.4744270587522613 0.8486656846381453 0 0 0 0 K06155 0.0 0.037037037037037 gntT; Gnt-I system high-affinity gluconate transporter 415.0 14.0 11.0 2.0 0.823529411764706 EG 0.0 17.0 1.0 1.0 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 17.0 0.0 1.0 0.0065934674827343 0.0153517370148383 0.0109726022487863 0.0087582695321039 0 0 0 0 K06156 0.0 0.0427350427350427 gntU; Gnt-I system low-affinity gluconate transporter 435.0 14.0 13.0 2.0 0.933333333333333 EG 0.0 15.0 1.0 1.0 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 15.0 0.0 1.0 0.0446540245650476 0.135703327138317 0.0901786758516823 0.0910493025732694 0 0 0 0 K06157 0.0 0.0056980056980056 idnT; Gnt-II system L-idonate transporter 431.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 4.0 0.0 1.0 8.68745928178432e-11 0.0317778586547497 0.0158889293708121 0.0317778585678751 0 0 0 0 K06158 0.0514285714285714 0.7834757834757835 ABCF3; ATP-binding cassette, subfamily F, member 3 277.0 353.0 338.0 3.0 0.938829787234042 S 18.0 358.0 2.0 0.978723404255319 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 376.0 0.0478723404255319 0.952127659574468 0.0048028275105346 0.548725416418215 0.2767641219643748 0.5439225889076804 0 0 0 0 K06159 0.0 0.0085470085470085 yojI; multidrug/microcin transport system ATP-binding/permease protein path:map02010 ABC transporters 19.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG4615 ABC-type_siderophore_export_system,_fused_ATPase_and_permease_components PvdE 4.0 0.0 1.0 0.0124993296622847 0.0244014878272154 0.01845040874475 0.0119021581649307 0 0 0 0 K06160 0.0 0.0541310541310541 pvdE; putative pyoverdin transport system ATP-binding/permease protein path:map02010 ABC transporters 443.0 24.0 19.0 3.0 0.75 V 0.0 32.0 2.0 0.96875 COG4615 ABC-type_siderophore_export_system,_fused_ATPase_and_permease_components PvdE 32.0 0.0 1.0 0.0047011982328574 0.0224122031325622 0.0135567006827098 0.0177110048997048 0 0 0 0 K06161 0.0 0.0028490028490028 syrD; putative syringomycin transport system ATP-binding/permease protein path:map02010 ABC transporters 560.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG4615 ABC-type_siderophore_export_system,_fused_ATPase_and_permease_components PvdE 1.0 0.0 1.0 0 0 0 0 K06162 0.0228571428571428 0.1111111111111111 phnM; alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase [EC:3.6.1.63] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 238.0 69.0 68.0 2.0 0.985714285714286 P 8.0 62.0 3.0 0.885714285714286 COG3454 Alpha-D-ribose_1-methylphosphonate_5-triphosphate_diphosphatase_PhnM PhnM 70.0 0.1142857142857142 0.8857142857142857 0.0365990500230062 0.0888218120403406 0.0627104310316734 0.0522227620173344 0 0 0 0 K06163 0.0171428571428571 0.0883190883190883 phnJ; alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase [EC:4.7.1.1] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 270.0 36.0 32.0 2.0 0.9 P 6.0 34.0 1.0 1.0 COG3627 Alpha-D-ribose_1-methylphosphonate_5-phosphate_C-P_lyase_PhnJ PhnJ 40.0 0.15 0.85 0.0279152355610237 0.0742248181948426 0.0510700268779331 0.0463095826338189 0 0 0 0 K06164 0.0171428571428571 0.0854700854700854 phnI; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [EC:2.7.8.37] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 308.0 37.0 0.0 1.0 1.0 P 6.0 31.0 1.0 1.0 COG3626 Alpha-D-ribose_1-methylphosphonate_5-triphosphate_synthase_subunit_PhnI PhnI 37.0 0.1621621621621621 0.8378378378378378 0.0340530372469962 0.0899502915313437 0.0620016643891699 0.0558972542843475 0 0 0 0 K06165 0.0171428571428571 0.0883190883190883 phnH; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH [EC:2.7.8.37] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 107.0 40.0 0.0 1.0 1.0 P 6.0 34.0 1.0 1.0 COG3625 Alpha-D-ribose_1-methylphosphonate_5-triphosphate_synthase_subunit_PhnH PhnH 40.0 0.15 0.85 0.0208831606296976 0.0617105658332133 0.0412968632314554 0.0408274052035157 0 0 0 0 K06166 0.1314285714285714 0.0883190883190883 phnG; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG [EC:2.7.8.37] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 88.0 85.0 0.0 1.0 1.0 P 54.0 31.0 2.0 0.623529411764706 COG1122 Energy-coupling_factor_transporter_ATP-binding_protein_EcfA2 EcfA2 85.0 0.6352941176470588 0.3647058823529411 0.352114448712895 0.856530135065307 0.6043222918891009 0.504415686352412 0 0 0 0 K06167 0.2514285714285714 0.3162393162393162 phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 118.0 207.0 196.0 2.0 0.94954128440367 S 98.0 120.0 1.0 1.0 COG1235 Phosphoribosyl_1,2-cyclic_phosphate_phosphodiesterase PhnP 218.0 0.4495412844036697 0.5504587155963303 0.0019827953940459 0.0216518515037232 0.0118173234488845 0.0196690561096773 0 0 0 0 K06168 0.0028571428571428 0.886039886039886 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] 281.0 294.0 274.0 2.0 0.936305732484076 J 1.0 313.0 1.0 1.0 COG0621 tRNA_A37_methylthiotransferase_MiaB MiaB 314.0 0.0031847133757961 0.9968152866242038 0.92110095913228 0.99221959685419 0.9566602779932348 0.07111863772191 0 0 1 1 K06169 0.0 0.131054131054131 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69] 165.0 52.0 0.0 1.0 1.0 FJ 0.0 52.0 1.0 1.0 COG4445 tRNA_isopentenyl-2-thiomethyl-A-37_hydroxylase_MiaE_(synthesis_of_2-methylthio-cis-ribozeatin) MiaE 52.0 0.0 1.0 0.0213151233959789 0.0304363103089116 0.0258757168524452 0.0091211869129326 0 0 0 0 K06173 0.4714285714285714 0.8803418803418803 truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] 95.0 504.0 0.0 1.0 1.0 J 168.0 336.0 1.0 1.0 COG0101 tRNA_U38,U39,U40_pseudouridine_synthase_TruA TruA 504.0 0.3333333333333333 0.6666666666666666 0.0201094611043907 0.171534352761328 0.0958219069328593 0.1514248916569373 0 0 0 0 K06174 0.8542857142857143 0.0 ABCE1, Rli1; ATP-binding cassette, sub-family E, member 1 446.0 301.0 294.0 2.0 0.977272727272727 E 308.0 0.0 1.0 1.0 COG1245 Translation_initiation_factor_RLI1,_contains_Fe-S_and_AAA+_ATPase_domains Rli1 308.0 1.0 0.0 0.953645124002058 0.940806883358658 0.947226003680358 0.0128382406434 0 0 1 1 K06175 0.0 0.0797720797720797 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26] 203.0 30.0 28.0 2.0 0.9375 J 0.0 32.0 2.0 0.9375 COG0564 Pseudouridine_synthase_RluA,_23S_rRNA-_or_tRNA-specific RluA 32.0 0.0 1.0 0.031970349195336 0.0389876367102003 0.0354789929527681 0.0070172875148643 0 0 0 0 K06176 0.8228571428571428 0.150997150997151 truD, PUS7; tRNA pseudouridine13 synthase [EC:5.4.99.27] 118.0 365.0 364.0 2.0 0.997267759562842 J 304.0 62.0 1.0 1.0 COG0585 tRNA(Glu)_U13_pseudouridine_synthase_TruD TruD 366.0 0.8306010928961749 0.1693989071038251 0.823222420816416 0.356080772694063 0.5896515967552395 0.4671416481223529 1 1 1 1 K06177 0.0142857142857142 0.4245014245014245 rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29] 100.0 199.0 0.0 1.0 1.0 J 5.0 193.0 1.0 1.0 COG0564 Pseudouridine_synthase_RluA,_23S_rRNA-_or_tRNA-specific RluA 198.0 0.0252525252525252 0.9747474747474748 0.689303622944827 0.0631190593434985 0.3762113411441627 0.6261845636013286 0 1 0 1 K06178 0.0314285714285714 0.8746438746438746 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] 126.0 343.0 342.0 2.0 0.997093023255814 J 12.0 332.0 1.0 1.0 COG1187 Pseudouridylate_synthase_RsuA,_specific_for_16S_rRNA_U516__and_23S_rRNA_U2605 RsuA 344.0 0.0348837209302325 0.9651162790697676 0.120663899330975 0.420212164611692 0.2704380319713335 0.299548265280717 0 0 0 0 K06179 0.0 0.3532763532763532 rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24] 125.0 136.0 135.0 2.0 0.992700729927007 J 0.0 137.0 3.0 0.985401459854015 COG0564 Pseudouridine_synthase_RluA,_23S_rRNA-_or_tRNA-specific RluA 137.0 0.0 1.0 0.0207294148273981 0.0183336908502454 0.0195315528388217 0.0023957239771526 0 0 0 0 K06180 0.0285714285714285 0.9743589743589745 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] 71.0 575.0 568.0 4.0 0.981228668941979 J 10.0 576.0 5.0 0.991467576791809 COG0564 Pseudouridine_synthase_RluA,_23S_rRNA-_or_tRNA-specific RluA 586.0 0.0170648464163822 0.9829351535836176 0.0933576022947695 0.644118901734989 0.3687382520148792 0.5507612994402195 0 0 0 0 K06181 0.0 0.2222222222222222 rluE; 23S rRNA pseudouridine2457 synthase [EC:5.4.99.20] 137.0 81.0 79.0 2.0 0.975903614457831 J 0.0 83.0 1.0 1.0 COG1187 Pseudouridylate_synthase_RsuA,_specific_for_16S_rRNA_U516__and_23S_rRNA_U2605 RsuA 83.0 0.0 1.0 0.0344418297205942 0.435603437529234 0.2350226336249141 0.4011616078086398 0 0 0 0 K06182 0.0142857142857142 0.3162393162393162 rluF; 23S rRNA pseudouridine2604 synthase [EC:5.4.99.21] 146.0 114.0 110.0 3.0 0.942148760330578 J 5.0 116.0 3.0 0.975206611570248 COG1187 Pseudouridylate_synthase_RsuA,_specific_for_16S_rRNA_U516__and_23S_rRNA_U2605 RsuA 121.0 0.0413223140495867 0.9586776859504132 0.0055943149242828 0.161767216448113 0.0836807656861979 0.1561729015238302 0 0 0 0 K06183 0.02 0.4586894586894587 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] 136.0 202.0 0.0 1.0 1.0 J 7.0 195.0 1.0 1.0 COG1187 Pseudouridylate_synthase_RsuA,_specific_for_16S_rRNA_U516__and_23S_rRNA_U2605 RsuA 202.0 0.0346534653465346 0.9653465346534652 0.34207331534285 0.289767064301553 0.3159201898222015 0.0523062510412969 0 0 0 0 K06186 0.0 0.094017094017094 bamE, smpA; outer membrane protein assembly factor BamE 77.0 19.0 4.0 2.0 0.558823529411765 J 0.0 34.0 1.0 1.0 COG2913 Outer_membrane_protein_assembly_factor_BamE,_lipoprotein_component_of_the_BamABCDE_complex BamE 34.0 0.0 1.0 0.0230144957192874 0.0430476150405433 0.0330310553799153 0.0200331193212559 0 0 0 0 K06187 0.0 0.9686609686609686 recR; recombination protein RecR path:map03440 Homologous recombination 159.0 340.0 333.0 2.0 0.979827089337176 L 0.0 347.0 2.0 0.979827089337176 COG0353 Recombinational_DNA_repair_protein_RecR RecR 347.0 0.0 1.0 0.0121972555224053 0.690465909532808 0.3513315825276066 0.6782686540104027 0 0 0 0 K06188 0.1371428571428571 0.2735042735042735 aqpZ; aquaporin Z 152.0 124.0 66.0 3.0 0.677595628415301 G 60.0 123.0 1.0 1.0 COG0580 Glycerol_uptake_facilitator_or_related_aquaporin_(Major_Intrinsic_protein_Family) GlpF 183.0 0.3278688524590163 0.6721311475409836 0.0468489878453254 0.534721712450159 0.2907853501477422 0.4878727246048335 0 0 0 0 K06189 0.0 0.1965811965811965 corC, tlyC; hemolysin (HlyC) family protein 206.0 41.0 14.0 3.0 0.585714285714286 S 0.0 70.0 2.0 0.614285714285714 COG1253 Hemolysin-related_protein,_contains_CBS_domains,_UPF0053_family TlyC 70.0 0.0 1.0 0.0185244107895543 0.0039395654281642 0.0112319881088592 0.01458484536139 0 0 0 0 K06190 0.0 0.150997150997151 ispZ; intracellular septation protein 159.0 56.0 0.0 1.0 1.0 D 0.0 56.0 1.0 1.0 COG2917 Intracellular_septation_protein_A YciB 56.0 0.0 1.0 0.0118860554062893 0.0210339101348265 0.0164599827705579 0.0091478547285372 0 0 0 0 K06191 0.0428571428571428 0.1566951566951566 nrdH; glutaredoxin-like protein NrdH 47.0 78.0 0.0 1.0 1.0 O 15.0 63.0 1.0 1.0 COG0695 Glutaredoxin GrxC 78.0 0.1923076923076923 0.8076923076923077 0.71395122316024 0.114320312302496 0.4141357677313679 0.599630910857744 0 1 0 1 K06192 0.0 0.168091168091168 pqiB; paraquat-inducible protein B 120.0 72.0 0.0 1.0 1.0 Q 0.0 72.0 2.0 0.944444444444444 COG1463 Periplasmic_subunit_MlaD_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaD 72.0 0.0 1.0 0.0013060671263646 0.0032949611261413 0.0023005141262529 0.0019888939997767 0 0 0 0 K06193 0.0371428571428571 0.2507122507122507 phnA; protein PhnA 84.0 91.0 88.0 2.0 0.968085106382979 P 13.0 91.0 3.0 0.875 COG2824 Uncharacterized_Zn-ribbon-containing_protein PhnA 104.0 0.125 0.875 0.0577624567698824 0.303823289236278 0.1807928730030802 0.2460608324663956 0 0 0 0 K06194 0.0 0.1794871794871795 nlpD; lipoprotein NlpD 142.0 33.0 14.0 3.0 0.492537313432836 DM 0.0 67.0 3.0 0.671641791044776 COG1388 LysM_repeat LysM 67.0 0.0 1.0 0.0064552839708328 0.0231569811087259 0.0148061325397793 0.0167016971378931 0 0 0 0 K06195 0.0 0.2051282051282051 apaG; ApaG protein 102.0 72.0 0.0 1.0 1.0 P 0.0 72.0 1.0 1.0 COG2967 Uncharacterized_conserved_protein_ApaG_affecting_Mg2+/Co2+_transport ApaG 72.0 0.0 1.0 0.0059439342230036 0.0087972780514379 0.0073706061372207 0.0028533438284343 0 0 0 0 K06196 0.2885714285714286 0.5185185185185185 ccdA; cytochrome c-type biogenesis protein 52.0 314.0 252.0 5.0 0.813471502590673 O 136.0 249.0 6.0 0.670984455958549 COG0785 Cytochrome_c_biogenesis_protein_CcdA CcdA 385.0 0.3532467532467532 0.6467532467532467 0.0516404854743944 0.778997441623006 0.4153189635487002 0.7273569561486116 0 0 0 0 K06197 0.0314285714285714 0.0256410256410256 chaB; cation transport regulator 57.0 17.0 12.0 2.0 0.772727272727273 S 12.0 11.0 1.0 1.0 COG4572 Cation_transport_regulator_ChaB ChaB 23.0 0.5217391304347826 0.4782608695652174 0.01463718526352 0.0438683611371322 0.0292527732003261 0.0292311758736122 0 0 0 0 K06198 0.0142857142857142 0.0655270655270655 coiA; competence protein CoiA 57.0 20.0 0.0 1.0 1.0 S 5.0 24.0 2.0 0.931034482758621 COG4469 Competence_protein_CoiA,_contains_predicted_nuclease_domain CoiA 29.0 0.1724137931034483 0.8275862068965517 0.0147661806092932 0.0671157767340007 0.0409409786716469 0.0523495961247074 0 0 0 0 K06199 0.3085714285714285 0.5698005698005698 crcB, FEX; fluoride exporter 47.0 313.0 204.0 4.0 0.734741784037559 D 167.0 259.0 3.0 0.990610328638498 COG0239 Fluoride_ion_exporter_CrcB/FEX,_affects_chromosome_condensation CrcB 426.0 0.392018779342723 0.607981220657277 0.0612582105702289 0.0807881582414246 0.0710231844058267 0.0195299476711957 0 0 0 0 K06200 0.1885714285714285 0.3304843304843304 cstA; carbon starvation protein 375.0 193.0 0.0 1.0 1.0 T 69.0 131.0 3.0 0.965 COG1966 Carbon_starvation_protein_CstA_(peptide/pyruvate_transporter) CstA 200.0 0.345 0.655 0.0036136755857828 0.0118200035884778 0.0077168395871303 0.008206328002695 0 0 0 0 K06201 0.0 0.2136752136752136 cutC; copper homeostasis protein 160.0 79.0 0.0 1.0 1.0 P 0.0 79.0 1.0 1.0 COG3142 Copper_homeostasis_protein_CutC CutC 79.0 0.0 1.0 0.0048457256497306 0.231771262295586 0.1183084939726583 0.2269255366458554 0 0 0 0 K06202 0.0 0.0569800569800569 cyaY; iron-sulfur cluster assembly protein CyaY 93.0 20.0 0.0 1.0 1.0 P 0.0 20.0 1.0 1.0 COG1965 Fe-S_cluster_assembly_protein_CyaY,_frataxin_homolog CyaY 20.0 0.0 1.0 0.0041914887306809 0.0088096517382926 0.0065005702344867 0.0046181630076117 0 0 0 0 K06203 0.0 0.1908831908831909 cysZ; CysZ protein 127.0 58.0 53.0 4.0 0.828571428571429 E 0.0 70.0 3.0 0.871428571428571 COG2981 Sulfate_transporter_CysZ CysZ 70.0 0.0 1.0 0.01254955084276 0.425749295621411 0.2191494232320855 0.413199744778651 0 0 0 0 K06204 0.0 0.4558404558404558 dksA; DnaK suppressor protein path:map02026 Biofilm formation - Escherichia coli 41.0 207.0 187.0 2.0 0.911894273127753 T 0.0 226.0 1.0 1.0 COG1734 RNA_polymerase-binding_transcription_factor_DksA DksA 226.0 0.0 1.0 0.0008031378470579 0.0128772358037423 0.0068401868254001 0.0120740979566843 0 0 0 0 K06205 0.0 0.0427350427350427 mioC; MioC protein 126.0 16.0 12.0 2.0 0.8 C 0.0 20.0 2.0 0.75 COG0716 Flavodoxin FldA 20.0 0.0 1.0 0.0086916147901382 0.0107081468796483 0.0096998808348932 0.0020165320895101 0 0 0 0 K06206 0.36 0.3190883190883191 sfsA; sugar fermentation stimulation protein A 92.0 234.0 211.0 3.0 0.906976744186046 S 142.0 116.0 2.0 0.918604651162791 COG1489 DNA-binding_protein,_stimulates_sugar_fermentation SfsA 258.0 0.5503875968992248 0.4496124031007752 0.97786762473559 0.839621642659719 0.9087446336976543 0.138245982075871 1 1 1 1 K06207 0.0 0.8490028490028491 typA, bipA; GTP-binding protein 518.0 303.0 0.0 1.0 1.0 T 0.0 303.0 1.0 1.0 COG1217 Predicted_membrane_GTPase_TypA/BipA_involved_in_stress_response TypA 303.0 0.0 1.0 0.0011148901662069 0.812499660873182 0.4068072755196945 0.8113847707069751 0 0 0 0 K06208 0.0 0.1823361823361823 aroH; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 107.0 66.0 0.0 1.0 1.0 E 0.0 66.0 1.0 1.0 COG4401 Chorismate_mutase_AroH AroH 66.0 0.0 1.0 0.0074593102210922 0.69376964940275 0.3506144798119211 0.6863103391816577 0 0 0 0 K06209 0.0 0.0854700854700854 pheB; chorismate mutase [EC:5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 133.0 29.0 28.0 2.0 0.966666666666667 S 0.0 30.0 2.0 0.966666666666667 COG4492 ACT_domain-containing_protein,_UPF0735_family PheB 30.0 0.0 1.0 0.001307306406184 0.0084362466315082 0.004871776518846 0.0071289402253242 0 0 0 0 K06211 0.0057142857142857 0.0341880341880341 nadR; HTH-type transcriptional regulator, transcriptional repressor of NAD biosynthesis genes [EC:2.7.7.1 2.7.1.22] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 128.0 16.0 0.0 1.0 1.0 H 3.0 13.0 4.0 0.3125 COG3172 Nicotinamide_riboside_kinase NadR3 16.0 0.1875 0.8125 0.107030854443684 0.159935140399898 0.133482997421791 0.052904285956214 0 0 0 0 K06212 0.0057142857142857 0.1111111111111111 focA; formate transporter 213.0 41.0 36.0 2.0 0.891304347826087 P 2.0 44.0 2.0 0.869565217391304 COG2116 Formate/nitrite_transporter_FocA,_FNT_family FocA 46.0 0.0434782608695652 0.9565217391304348 0.0880911133464019 0.221214056136639 0.1546525847415204 0.1331229427902371 0 0 0 0 K06213 0.1228571428571428 0.6666666666666666 mgtE; magnesium transporter 238.0 366.0 0.0 1.0 1.0 P 52.0 314.0 3.0 0.994535519125683 COG2239 Mg/Co/Ni_transporter_MgtE_(contains_CBS_domain) MgtE 366.0 0.1420765027322404 0.8579234972677595 0.0002823561360127 0.0013187478723502 0.0008005520041814 0.0010363917363374 0 0 0 0 K06214 0.0 0.0341880341880341 csgG; curli production assembly/transport component CsgG 219.0 12.0 0.0 1.0 1.0 M 0.0 12.0 1.0 1.0 COG1462 Curli_biogenesis_system_outer_membrane_secretion_channel_CsgG CsgG 12.0 0.0 1.0 0.0100115679617787 0.0207538663830111 0.0153827171723949 0.0107422984212324 0 0 0 0 K06215 0.5685714285714286 0.3105413105413105 pdxS, pdx1; pyridoxal 5'-phosphate synthase pdxS subunit [EC:4.3.3.6] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 263.0 322.0 0.0 1.0 1.0 H 209.0 113.0 1.0 1.0 COG0214 Pyridoxal_5'-phosphate_synthase_subunit_PdxS PdxS 322.0 0.6490683229813664 0.3509316770186335 0.471009190246845 0.9061226903463 0.6885659402965725 0.435113500099455 0 0 0 0 K06216 0.0028571428571428 0.0113960113960113 rbsU; putative ribose uptake protein 290.0 3.0 1.0 2.0 0.6 U 1.0 4.0 1.0 1.0 COG4975 Glucose_uptake_protein_GlcU GlcU 5.0 0.2 0.8 0.188591899219782 0.462681832572846 0.325636865896314 0.274089933353064 0 0 0 0 K06217 0.0 0.7749287749287749 phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins 205.0 283.0 0.0 1.0 1.0 T 0.0 283.0 2.0 0.978798586572438 COG1702 Phosphate_starvation-inducible_protein_PhoH,_predicted_ATPase PhoH 283.0 0.0 1.0 0.207293666584905 0.0078053290455839 0.1075494978152444 0.1994883375393211 0 0 0 0 K06218 0.0 0.0 relE, stbE; mRNA interferase RelE/StbE 397.0 345.0 6.0 0.874449339207049 DJ 0.0 0.0 9.0 0.951859956236324 COG2026 mRNA-degrading_endonuclease_RelE,_toxin_component_of_the_RelBE_toxin-antitoxin_system RelE 0.0 0 0 0 0 K06219 0.0085714285714285 0.0512820512820512 smtA, cmoM; tRNA 5-carboxymethoxyuridine methyltransferase [EC:2.1.1.-] 85.0 14.0 8.0 3.0 0.666666666666667 H 3.0 18.0 2.0 0.952380952380952 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 21.0 0.1428571428571428 0.8571428571428571 0.0779804685943841 0.244525333573118 0.161252901083751 0.1665448649787339 0 0 0 0 K06221 0.0 0.1025641025641025 dkgA; 2,5-diketo-D-gluconate reductase A [EC:1.1.1.346] 246.0 42.0 39.0 3.0 0.893617021276596 S 0.0 47.0 1.0 1.0 COG0656 Aldo/keto_reductase,_related_to_diketogulonate_reductase ARA1 47.0 0.0 1.0 0.004029035875039 0.0131356862267105 0.0085823610508747 0.0091066503516715 0 0 0 0 K06222 0.16 0.0455840455840455 dkgB; 2,5-diketo-D-gluconate reductase B [EC:1.1.1.346] 227.0 126.0 125.0 2.0 0.992125984251968 S 105.0 22.0 1.0 1.0 COG0656 Aldo/keto_reductase,_related_to_diketogulonate_reductase ARA1 127.0 0.8267716535433071 0.1732283464566929 0.119539163641015 0.0801126764291425 0.0998259200350787 0.0394264872118725 0 0 0 0 K06223 0.2285714285714285 0.2849002849002849 dam; DNA adenine methylase [EC:2.1.1.72] path:map03430 Mismatch repair 62.0 218.0 162.0 2.0 0.795620437956204 L 106.0 165.0 3.0 0.992700729927007 COG0338 DNA-adenine_methylase Dam 271.0 0.3911439114391143 0.6088560885608856 0.176165162428254 0.716390427910728 0.446277795169491 0.5402252654824741 0 0 0 0 K06224 0.0057142857142857 0.0 HH; hedgehog path:map04341 Hedgehog signaling pathway - fly 183.0 2.0 0.0 1.0 1.0 M 2.0 0.0 1.0 1.0 KOG3638 2.0 1.0 0.0 0 0 0 0 K06234 0.0142857142857142 0.0 RAB23; Ras-related protein Rab-23 171.0 10.0 0.0 1.0 1.0 U 10.0 0.0 1.0 1.0 KOG4252 10.0 1.0 0.0 0.499780275675322 0.696859943078841 0.5983201093770816 0.197079667403519 0 0 0 0 K06236 0.0 0.0056980056980056 COL1A; collagen type I alpha path:map04151,path:map04510,path:map04512,path:map04611,path:map04926,path:map04933,path:map04974,path:map05146,path:map05165,path:map05205,path:map05415 PI3K-Akt signaling pathway,Focal adhesion,ECM-receptor interaction,Platelet activation,Relaxin signaling pathway,AGE-RAGE signaling pathway in diabetic complications,Protein digestion and absorption,Amoebiasis,Human papillomavirus infection,Proteoglycans in cancer,Diabetic cardiomyopathy 340.0 1.0 0.0 2.0 0.5 MU 0.0 2.0 2.0 0.5 COG3468 Autotransporter_adhesin_AidA AidA 2.0 0.0 1.0 0 0 0 0 K06237 0.0 0.0056980056980056 COL4A; collagen type IV alpha path:map04151,path:map04510,path:map04512,path:map04926,path:map04933,path:map04974,path:map05146,path:map05165,path:map05200,path:map05222 PI3K-Akt signaling pathway,Focal adhesion,ECM-receptor interaction,Relaxin signaling pathway,AGE-RAGE signaling pathway in diabetic complications,Protein digestion and absorption,Amoebiasis,Human papillomavirus infection,Pathways in cancer,Small cell lung cancer 266.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG4675 Phage_tail_collar_domain MdpB 3.0 0.0 1.0 0 0 0 0 K06260 0.0028571428571428 0.0 GP5, CD42d; platelet glycoprotein V path:map04512,path:map04611,path:map04640 ECM-receptor interaction,Platelet activation,Hematopoietic cell lineage 298.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG4886 Leucine-rich_repeat_(LRR)_protein LRR 1.0 1.0 0.0 0 0 0 0 K06268 0.0 0.0028490028490028 PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit path:map04010,path:map04020,path:map04022,path:map04114,path:map04218,path:map04310,path:map04360,path:map04370,path:map04380,path:map04625,path:map04650,path:map04658,path:map04659,path:map04660,path:map04662,path:map04720,path:map04724,path:map04921,path:map04922,path:map04924,path:map05010,path:map05014,path:map05020,path:map05022,path:map05031,path:map05152,path:map05163,path:map05166,path:map05167,path:map05170,path:map05235,path:map05417 MAPK signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway,Oocyte meiosis,Cellular senescence,Wnt signaling pathway,Axon guidance,VEGF signaling pathway,Osteoclast differentiation,C-type lectin receptor signaling pathway,Natural killer cell mediated cytotoxicity,Th1 and Th2 cell differentiation,Th17 cell differentiation,T cell receptor signaling pathway,B cell receptor signaling pathway,Long-term potentiation,Glutamatergic synapse,Oxytocin signaling pathway,Glucagon signaling pathway,Renin secretion,Alzheimer disease,Amyotrophic lateral sclerosis,Prion disease,Pathways of neurodegeneration - multiple diseases,Amphetamine addiction,Tuberculosis,Human cytomegalovirus infection,Human T-cell leukemia virus 1 infection,Kaposi sarcoma-associated herpesvirus infection,Human immunodeficiency virus 1 infection,PD-L1 expression and PD-1 checkpoint pathway in cancer,Lipid and atherosclerosis 77.0 1.0 0.0 1.0 1.0 DTZ 0.0 1.0 1.0 1.0 COG5126 Ca2+-binding_protein,_EF-hand_superfamily FRQ1 1.0 0.0 1.0 0 0 0 0 K06269 0.0542857142857142 0.0028490028490028 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] path:map03015,path:map04022,path:map04024,path:map04113,path:map04114,path:map04218,path:map04261,path:map04270,path:map04390,path:map04510,path:map04611,path:map04720,path:map04728,path:map04750,path:map04810,path:map04910,path:map04921,path:map04931,path:map05031,path:map05034,path:map05168,path:map05205,path:map05415 mRNA surveillance pathway,cGMP-PKG signaling pathway,cAMP signaling pathway,Meiosis - yeast,Oocyte meiosis,Cellular senescence,Adrenergic signaling in cardiomyocytes,Vascular smooth muscle contraction,Hippo signaling pathway,Focal adhesion,Platelet activation,Long-term potentiation,Dopaminergic synapse,Inflammatory mediator regulation of TRP channels,Regulation of actin cytoskeleton,Insulin signaling pathway,Oxytocin signaling pathway,Insulin resistance,Amphetamine addiction,Alcoholism,Herpes simplex virus 1 infection,Proteoglycans in cancer,Diabetic cardiomyopathy 42.0 22.0 20.0 2.0 0.916666666666667 T 23.0 1.0 2.0 0.916666666666667 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 24.0 0.9583333333333334 0.0416666666666666 0.241385642849121 0.487231195377977 0.364308419113549 0.2458455525288559 0 0 0 0 K06281 0.0885714285714285 0.2079772079772079 hyaB, hybC; hydrogenase large subunit [EC:1.12.99.6] path:map00633,path:map01120,path:map02020 Nitrotoluene degradation,Microbial metabolism in diverse environments,Two-component system 292.0 142.0 0.0 1.0 1.0 C 34.0 108.0 1.0 1.0 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 142.0 0.2394366197183098 0.7605633802816901 0.895327805263585 0.919520421122199 0.907424113192892 0.0241926158586139 1 1 1 1 K06282 0.0885714285714285 0.2165242165242165 hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6] path:map00633,path:map01120,path:map02020 Nitrotoluene degradation,Microbial metabolism in diverse environments,Two-component system 197.0 136.0 0.0 1.0 1.0 C 35.0 101.0 1.0 1.0 COG1740 Ni,Fe-hydrogenase_I_small_subunit HyaA 136.0 0.2573529411764705 0.7426470588235294 0.855596810966422 0.53405586788953 0.694826339427976 0.321540943076892 1 1 1 1 K06283 0.0 0.0797720797720797 spoIIID; putative DeoR family transcriptional regulator, stage III sporulation protein D 80.0 29.0 0.0 1.0 1.0 K 0.0 29.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 29.0 0.0 1.0 0.0033323956140093 0.0719760235323054 0.0376542095731573 0.068643627918296 0 0 0 0 K06284 0.0114285714285714 0.0911680911680911 abrB; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes 70.0 53.0 0.0 1.0 1.0 K 5.0 48.0 1.0 1.0 COG2002 Bifunctional_DNA-binding_transcriptional_regulator_of_stationary/sporulation/toxin_gene_expression_and_antitoxin_component_of_the_YhaV-PrlF_toxin-antitoxin_module AbrB 53.0 0.0943396226415094 0.9056603773584906 0.0017228241545493 0.0269798723789449 0.0143513482667471 0.0252570482243956 0 0 0 0 K06285 0.0 0.0398860398860398 mtrB; transcription attenuation protein (tryptophan RNA-binding attenuator protein) 69.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 2E4ES 14.0 0.0 1.0 0.0056527809611746 0.0394494874750139 0.0225511342180942 0.0337967065138393 0 0 0 0 K06286 0.0 0.0455840455840455 ezrA; septation ring formation regulator 510.0 16.0 0.0 1.0 1.0 D 0.0 16.0 1.0 1.0 COG4477 Septation_ring_formation_regulator_EzrA EzrA 16.0 0.0 1.0 0.0044489736704887 2.13944185317994e-11 0.0022244868459415 0.0044489736490942 0 0 0 0 K06287 0.1257142857142857 0.8005698005698005 yhdE; nucleoside triphosphate pyrophosphatase [EC:3.6.1.-] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 76.0 380.0 378.0 4.0 0.989583333333333 D 44.0 340.0 2.0 0.9921875 COG0424 7-methyl-GTP_pyrophosphatase_and_related_NTP_pyrophosphatases,_Maf/HAM1_superfamily Maf 384.0 0.1145833333333333 0.8854166666666666 0.0919508064770679 0.274810284768172 0.1833805456226199 0.1828594782911041 0 0 0 0 K06294 0.0 0.0256410256410256 gerD; spore germination protein D 194.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 29HQ2 9.0 0.0 1.0 6.78657866556507e-07 5.44571703932309e-06 3.062187452939798e-06 4.767059172766583e-06 0 0 0 0 K06295 0.0 0.0598290598290598 gerKA; spore germination protein KA 378.0 53.0 0.0 1.0 1.0 EG 0.0 53.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 53.0 0.0 1.0 0.001394601617823 0.128485857458205 0.064940229538014 0.127091255840382 0 0 0 0 K06296 0.0 0.0484330484330484 gerKB; spore germination protein KB 259.0 39.0 28.0 3.0 0.75 E 0.0 53.0 3.0 0.735849056603774 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 53.0 0.0 1.0 0.001331764370378 0.0602473646687778 0.0307895645195779 0.0589156002983998 0 0 0 0 K06297 0.0 0.0626780626780626 gerKC; spore germination protein KC 213.0 51.0 0.0 1.0 1.0 S 0.0 51.0 12.0 0.529411764705882 2DBJR 51.0 0.0 1.0 0.0019068134059988 0.094023668367572 0.0479652408867854 0.0921168549615732 0 0 0 0 K06298 0.0 0.0512820512820512 gerM; germination protein M 225.0 18.0 16.0 2.0 0.9 S 0.0 20.0 1.0 1.0 COG5401 Spore_germination_protein_GerM GerM 20.0 0.0 1.0 0.0882253957389539 0.134887878644054 0.1115566371915039 0.0466624829051001 0 0 0 0 K06299 0.0 0.0056980056980056 gerPA; spore germination protein PA 71.0 4.0 0.0 1.0 1.0 S 0.0 4.0 2.0 0.5 2DP0U 4.0 0.0 1.0 5.620445016292351e-09 3.12187409386103e-06 1.563747269438661e-06 3.1162536488447376e-06 0 0 0 0 K06300 0.0 0.0056980056980056 gerPB; spore germination protein PB 60.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EBHF 2.0 0.0 1.0 0 0 0 0 K06301 0.0 0.0056980056980056 gerPC; spore germination protein PC 153.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EBJR 2.0 0.0 1.0 0 0 0 0 K06302 0.0 0.0028490028490028 gerPD; spore germination protein PD 60.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2C5QJ 1.0 0.0 1.0 0 0 0 0 K06303 0.0 0.0056980056980056 gerPE; spore germination protein PE 109.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EEB8 2.0 0.0 1.0 0 0 0 0 K06304 0.0 0.0056980056980056 gerPF; spore germination protein PF 72.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DP0U 2.0 0.0 1.0 0 0 0 0 K06305 0.0 0.0199430199430199 gerQ; spore germination protein Q 97.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 2CWP1 8.0 0.0 1.0 1.81900541888556e-06 0.0012466059200438 0.0006242124627313 0.0012447869146249 0 0 0 0 K06306 0.0 0.0398860398860398 yaaH; spore germination protein 295.0 16.0 14.0 2.0 0.888888888888889 M 0.0 18.0 2.0 0.722222222222222 COG1388 LysM_repeat LysM 18.0 0.0 1.0 0.0220981730609423 0.0758045133257837 0.048951343193363 0.0537063402648414 0 0 0 0 K06307 0.0 0.0142450142450142 yfkQ; spore germination protein 455.0 8.0 0.0 1.0 1.0 EG 0.0 8.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 8.0 0.0 1.0 0.0216904174862391 0.109187911733655 0.065439164609947 0.0874974942474159 0 0 0 0 K06308 0.0 0.0142450142450142 yfkR; spore germination protein 367.0 5.0 0.0 1.0 1.0 S 0.0 5.0 3.0 0.4 2DBIQ 5.0 0.0 1.0 1.5782154888262e-07 0.0009242686880786 0.0004622132548137 0.0009241108665297 0 0 0 0 K06310 0.0 0.0341880341880341 yndD; spore germination protein 472.0 15.0 0.0 1.0 1.0 EG 0.0 15.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 15.0 0.0 1.0 0.010131222284653 0.0855640895350759 0.0478476559098644 0.0754328672504228 0 0 0 0 K06311 0.0 0.0313390313390313 yndE; spore germination protein 356.0 13.0 0.0 1.0 1.0 E 0.0 14.0 3.0 0.5 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 14.0 0.0 1.0 0.0005387620322391 0.0875480362309343 0.0440433991315867 0.0870092741986952 0 0 0 0 K06312 0.0 0.0199430199430199 yndF; spore germination protein 337.0 9.0 0.0 1.0 1.0 S 0.0 9.0 2.0 0.666666666666667 2DB7M 9.0 0.0 1.0 0.0057713963119532 0.0864945376402487 0.0461329669761009 0.0807231413282955 0 0 0 0 K06313 0.0 0.0541310541310541 ypeB; spore germination protein 392.0 20.0 0.0 1.0 1.0 H 0.0 20.0 1.0 1.0 COG2959 Proteobacterial_HemX_domain,_involved_in_2-ketogluconate_production_(unrelated_to_B._subtilis_HemX,_COG0755,_no_evidence_of_involvement_in_heme_biosynthesis) HemX 20.0 0.0 1.0 0.0061779025610407 0.0919888699756793 0.04908338626836 0.0858109674146386 0 0 0 0 K06314 0.0 0.0256410256410256 rsfA; prespore-specific regulator 175.0 8.0 0.0 1.0 1.0 S 0.0 11.0 2.0 0.636363636363636 2C8MW 11.0 0.0 1.0 3.07002267232948e-07 6.57920137269127e-05 3.304950799707282e-05 6.548501145967975e-05 0 0 0 0 K06315 0.0 0.0056980056980056 splA; transcriptional regulator of the spore photoproduct lyase operon 82.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EURH 2.0 0.0 1.0 0 0 0 0 K06317 0.0342857142857142 0.0598290598290598 bofA; inhibitor of the pro-sigma K processing machinery 65.0 32.0 0.0 1.0 1.0 S 13.0 22.0 11.0 0.342857142857143 2DRM3 35.0 0.3714285714285714 0.6285714285714286 0.0075357439723025 0.0131658329072738 0.0103507884397881 0.0056300889349713 0 0 0 0 K06318 0.0 0.0085470085470085 bofC; forespore regulator of the sigma-K checkpoint 80.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2DGQY 3.0 0.0 1.0 0 0 0 0 K06320 0.0142857142857142 0.0883190883190883 cgeB; spore maturation protein CgeB 110.0 25.0 9.0 3.0 0.581395348837209 S 6.0 37.0 2.0 0.976744186046512 COG4641 Spore_maturation_protein_CgeB 43.0 0.1395348837209302 0.8604651162790697 0.0257619309291693 0.0845029428049132 0.0551324368670412 0.0587410118757439 0 0 0 0 K06323 0.0114285714285714 0.0113960113960113 cgeE; spore maturation protein CgeE 126.0 8.0 0.0 1.0 1.0 K 4.0 4.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 8.0 0.5 0.5 0.128415952903465 0.157026084295531 0.1427210185994979 0.028610131392066 0 0 0 0 K06324 0.0371428571428571 0.0398860398860398 cotA; spore coat protein A, manganese oxidase [EC:1.16.3.3] 330.0 36.0 0.0 1.0 1.0 Q 16.0 20.0 2.0 0.972222222222222 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 36.0 0.4444444444444444 0.5555555555555556 0.0011810460305574 0.0041707994391305 0.0026759227348439 0.0029897534085731 0 0 0 0 K06325 0.0 0.0056980056980056 cotB; spore coat protein B 172.0 0.0 2.0 1.0 1.0 2E48W 2.0 0.0 1.0 0 0 0 0 K06327 0.0 0.0113960113960113 cotD; spore coat protein D 73.0 3.0 0.0 1.0 1.0 S 0.0 4.0 3.0 0.5 2DMW7 4.0 0.0 1.0 3.2450928404248595e-11 1.76470373981078e-05 8.823534924518102e-06 1.7647004947179394e-05 0 0 0 0 K06328 0.0 0.0284900284900284 cotE; spore coat protein E 165.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 2BYGR 11.0 0.0 1.0 0.0019562865350937 0.0037624089683622 0.0028593477517279 0.0018061224332685 0 0 0 0 K06329 0.0 0.0085470085470085 cotF; spore coat protein F 97.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG5577 Spore_coat_protein_CotF CotF 3.0 0.0 1.0 0 0 0 0 K06330 0.0 0.0341880341880341 cotH; spore coat protein H 304.0 12.0 0.0 1.0 1.0 M 0.0 12.0 1.0 1.0 COG5337 Spore_coat_protein_CotH CotH 12.0 0.0 1.0 0.0342486785128088 0.0609581253107508 0.0476034019117798 0.026709446797942 0 0 0 0 K06331 0.0 0.0142450142450142 cotI; spore coat protein I 323.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG2334 Ser/Thr_protein_kinase_RdoA_involved_in_Cpx_stress_response,_MazF_antagonist SrkA 5.0 0.0 1.0 1.38593625758415e-06 0.0004701328215339 0.0002357593788957 0.0004687468852763 0 0 0 0 K06332 0.0 0.0142450142450142 cotJA; spore coat protein JA 63.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2E85N 5.0 0.0 1.0 7.68076820475128e-06 0.0030157555318271 0.0015117181500159 0.0030080747636223 0 0 0 0 K06333 0.0 0.0598290598290598 cotJB; spore coat protein JB 64.0 21.0 0.0 1.0 1.0 S 0.0 21.0 2.0 0.952380952380952 2E34J 21.0 0.0 1.0 0.0057289964744721 0.13375873623397 0.069743866354221 0.1280297397594979 0 0 0 0 K06334 0.0 0.0655270655270655 cotJC; spore coat protein JC 148.0 29.0 0.0 1.0 1.0 P 0.0 29.0 1.0 1.0 COG3546 Mn-containing_catalase_(includes_spore_coat_protein_CotJC) CotJC 29.0 0.0 1.0 0.0060060193859329 0.0350914850867509 0.0205487522363418 0.029085465700818 0 0 0 0 K06335 0.0 0.0256410256410256 cotM; spore coat protein M 123.0 10.0 0.0 1.0 1.0 O 0.0 10.0 1.0 1.0 COG0071 Small_heat_shock_protein_IbpA,_HSP20_family IbpA 10.0 0.0 1.0 0.0532450157686085 0.129956199117658 0.0916006074431332 0.0767111833490494 0 0 0 0 K06336 0.0 0.0085470085470085 tasA, cotN; spore coat-associated protein N 185.0 6.0 0.0 1.0 1.0 S 0.0 6.0 2.0 0.833333333333333 2CA96 6.0 0.0 1.0 2.19935423821242e-06 0.0011618834224132 0.0005820413883257 0.0011596840681749 0 0 0 0 K06337 0.0 0.0142450142450142 cotS; spore coat-associated protein S 326.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG2334 Ser/Thr_protein_kinase_RdoA_involved_in_Cpx_stress_response,_MazF_antagonist SrkA 6.0 0.0 1.0 3.6063702031905e-06 0.0019443397604389 0.000973973065321 0.0019407333902357 0 0 0 0 K06338 0.02 0.0427350427350427 cotSA; spore coat protein SA 183.0 23.0 0.0 1.0 1.0 M 7.0 16.0 2.0 0.956521739130435 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 23.0 0.3043478260869565 0.6956521739130435 0.254879416815456 0.554918830569011 0.4048991236922335 0.300039413753555 0 0 0 0 K06341 0.0 0.0028490028490028 cotW; spore coat protein W 72.0 0.0 1.0 1.0 1.0 2EG2J 1.0 0.0 1.0 0 0 0 0 K06342 0.0 0.0085470085470085 cotX; spore coat protein X 140.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2CFVW 5.0 0.0 1.0 8.39459771543456e-09 0.0171026291485951 0.0085513187715964 0.0171026207539973 0 0 0 0 K06343 0.0 0.0056980056980056 cotY; spore coat protein Y 163.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 29X3J 2.0 0.0 1.0 0 0 0 0 K06344 0.0 0.0085470085470085 cotZ; spore coat protein Z 122.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 28Q17 4.0 0.0 1.0 1.09950697628733e-06 1.5801671499235099e-13 5.497535671520225e-07 1.099506818270615e-06 0 0 0 0 K06345 0.0 0.0028490028490028 coxA; spore cortex protein 235.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2C7CE 1.0 0.0 1.0 0 0 0 0 K06346 0.0 0.5527065527065527 jag; spoIIIJ-associated protein 91.0 197.0 0.0 1.0 1.0 S 0.0 195.0 1.0 1.0 COG1847 Predicted_RNA-binding_protein_Jag_(SpoIIIJ-associated),_conains_KH_and_R3H_domains Jag 195.0 0.0 1.0 0.106020347881635 0.863338790072837 0.4846795689772359 0.757318442191202 0 0 0 0 K06347 0.0 0.0113960113960113 kapB; kinase-associated protein B path:map02020 Two-component system 116.0 3.0 2.0 2.0 0.75 G 0.0 4.0 1.0 1.0 2DNAX 4.0 0.0 1.0 1.91517390849527e-07 0.022872526603925 0.0114363590606579 0.0228723350865341 0 0 0 0 K06348 0.0 0.0028490028490028 kapD; sporulation inhibitor KapD 281.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG5018 3'-5'_exonuclease_KapD,_inhibitor_of_KinA-controlled_sporulation KapD 1.0 0.0 1.0 0 0 0 0 K06349 0.0 0.0313390313390313 kbaA; KinB signaling pathway activation protein 174.0 9.0 7.0 2.0 0.818181818181818 S 0.0 11.0 1.0 1.0 COG2194 Phosphoethanolamine_transferase_for_periplasmic_glucans_OpgE,_AlkP_superfamily OpgE 11.0 0.0 1.0 0.0021304001316317 0.0048100575186787 0.0034702288251552 0.002679657387047 0 0 0 0 K06350 0.0057142857142857 0.1082621082621082 kipA; antagonist of KipI 207.0 44.0 0.0 1.0 1.0 E 2.0 42.0 2.0 0.977272727272727 COG1984 5-oxoprolinase_subunit_C/Allophanate_hydrolase_subunit_2 PxpC 44.0 0.0454545454545454 0.9545454545454546 0.0343716008423802 0.355375361789823 0.1948734813161016 0.3210037609474427 0 0 0 0 K06351 0.0028571428571428 0.1139601139601139 kipI; inhibitor of KinA 155.0 43.0 0.0 1.0 1.0 E 1.0 42.0 1.0 1.0 COG2049 5-oxoprolinase_subunit_B/Allophanate_hydrolase_subunit_1 PxpB 43.0 0.0232558139534883 0.9767441860465116 0.0239675302280415 0.346262442467671 0.1851149863478562 0.3222949122396295 0 0 0 0 K06359 0.0 0.0028490028490028 rapA, spo0L; response regulator aspartate phosphatase A (stage 0 sporulation protein L) [EC:3.1.-.-] path:map02024 Quorum sensing 303.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K06370 0.0 0.0113960113960113 safA; morphogenetic protein associated with SpoVID 208.0 3.0 2.0 2.0 0.75 M 0.0 4.0 2.0 0.75 COG1388 LysM_repeat LysM 4.0 0.0 1.0 0.0340003990193018 0.0742957528590362 0.0541480759391689 0.0402953538397344 0 0 0 0 K06371 0.0 0.0142450142450142 sda; developmental checkpoint coupling sporulation initiation to replication initiation 42.0 5.0 0.0 1.0 1.0 S 0.0 5.0 2.0 0.8 2EIH6 5.0 0.0 1.0 9.75753739847359e-07 0.0006110296165831 0.0003060026851614 0.0006100538628432 0 0 0 0 K06373 0.0 0.1396011396011396 spmA; spore maturation protein A 184.0 52.0 0.0 1.0 1.0 S 0.0 52.0 2.0 0.692307692307692 COG2715 Spore_maturation_protein_SpmA_(function_unknown) SpmA 52.0 0.0 1.0 0.016059861112812 0.229749821952618 0.122904841532715 0.213689960839806 0 0 0 0 K06374 0.0 0.1253561253561253 spmB; spore maturation protein B 164.0 46.0 0.0 1.0 1.0 S 0.0 46.0 1.0 1.0 COG0700 Spore_maturation_protein_SpmB_(function_unknown) SpmB 46.0 0.0 1.0 0.0058953245811297 0.141634440746862 0.0737648826639958 0.1357391161657322 0 0 0 0 K06375 0.0 0.0227920227920227 spo0B; stage 0 sporulation protein B (sporulation initiation phosphotransferase) [EC:2.7.-.-] path:map02020,path:map02024 Two-component system,Quorum sensing 156.0 8.0 0.0 1.0 1.0 T 0.0 8.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 8.0 0.0 1.0 1.43997460572181e-07 1.72304186867593e-07 1.58150823719887e-07 2.830672629541201e-08 0 0 0 0 K06377 0.0285714285714285 0.0598290598290598 spo0M; sporulation-control protein 166.0 44.0 41.0 2.0 0.936170212765957 S 11.0 36.0 1.0 1.0 COG4326 Stage_0_sporulation-control_protein_Spo0M Spo0M 47.0 0.2340425531914893 0.7659574468085106 0.0045793950563986 0.0091229395770073 0.0068511673167029 0.0045435445206086 0 0 0 0 K06378 0.0028571428571428 0.2079772079772079 spoIIAA; stage II sporulation protein AA (anti-sigma F factor antagonist) 39.0 101.0 0.0 1.0 1.0 T 1.0 100.0 1.0 1.0 COG1366 Anti-anti-sigma_regulatory_factor_(antagonist_of_anti-sigma_factor) SpoIIAA 101.0 0.0099009900990099 0.99009900990099 0.0051731267277254 0.0546924525131459 0.0299327896204356 0.0495193257854205 0 0 0 0 K06379 0.0 0.1082621082621082 spoIIAB; stage II sporulation protein AB (anti-sigma F factor) [EC:2.7.11.1] 121.0 27.0 14.0 2.0 0.675 T 0.0 40.0 2.0 0.975 COG2172 Anti-sigma_regulatory_factor_(Ser/Thr_protein_kinase) RsbW 40.0 0.0 1.0 0.0019584922325433 0.0160682320743787 0.009013362153461 0.0141097398418354 0 0 0 0 K06380 0.0 0.0142450142450142 spoIIB; stage II sporulation protein B 276.0 0.0 5.0 3.0 0.4 2E7Z4 5.0 0.0 1.0 0 0 0 0 K06381 0.0 0.3247863247863248 spoIID; stage II sporulation protein D 35.0 160.0 154.0 4.0 0.952380952380952 D 0.0 168.0 7.0 0.910714285714286 COG2385 Peptidoglycan_hydrolase_(amidase)_enhancer_domain_SpoIID SpoIID 168.0 0.0 1.0 0.268184374688166 0.52769458077354 0.397939477730853 0.259510206085374 0 0 0 0 K06382 0.0114285714285714 0.1054131054131054 spoIIE; stage II sporulation protein E [EC:3.1.3.16] 98.0 43.0 42.0 2.0 0.977272727272727 KT 4.0 40.0 4.0 0.613636363636364 COG2208 Phosphoserine_phosphatase_RsbU,_regulator_of_sigma_subunit RsbU 44.0 0.0909090909090909 0.9090909090909092 0.0038327373608812 0.0909293807430434 0.0473810590519623 0.0870966433821621 0 0 0 0 K06383 0.0 0.0769230769230769 spoIIGA; stage II sporulation protein GA (sporulation sigma-E factor processing peptidase) [EC:3.4.23.-] 180.0 15.0 5.0 3.0 0.555555555555556 M 0.0 27.0 2.0 0.962962962962963 29ECG 27.0 0.0 1.0 0.0072271893741935 0.0117929309376315 0.0095100601559125 0.004565741563438 0 0 0 0 K06384 0.2485714285714285 0.0883190883190883 spoIIM; stage II sporulation protein M 87.0 122.0 117.0 2.0 0.960629921259842 S 94.0 37.0 4.0 0.969465648854962 COG1300 Stage_II_sporulation_protein_SpoIIM,_component_of_the_engulfment_complex SpoIIM 131.0 0.7175572519083969 0.2824427480916031 0.0847949004525671 0.774777551721208 0.4297862260868875 0.6899826512686409 0 0 0 0 K06385 0.0028571428571428 0.1168091168091168 spoIIP; stage II sporulation protein P 81.0 34.0 23.0 5.0 0.596491228070175 M 1.0 56.0 6.0 0.596491228070175 COG0860 N-acetylmuramoyl-L-alanine_amidase AmiC 57.0 0.0175438596491228 0.9824561403508772 0.0062535838177148 0.410484881075462 0.2083692324465884 0.4042312972577472 0 0 0 0 K06386 0.0 0.0284900284900284 spoIIQ; stage II sporulation protein Q 195.0 10.0 0.0 1.0 1.0 M 0.0 10.0 1.0 1.0 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 10.0 0.0 1.0 0.0030443558561178 0.0031183180437816 0.0030813369499497 7.39621876638002e-05 0 0 0 0 K06387 0.0 0.0769230769230769 spoIIR; stage II sporulation protein R 137.0 29.0 0.0 1.0 1.0 S 0.0 29.0 1.0 1.0 2AUKD 29.0 0.0 1.0 0.0027690418686805 0.0603293473750606 0.0315491946218705 0.0575603055063801 0 0 0 0 K06390 0.0 0.0797720797720797 spoIIIAA; stage III sporulation protein AA 259.0 28.0 0.0 1.0 1.0 S 0.0 28.0 2.0 0.964285714285714 COG3854 Stage_III_sporulation_protein_SpoIIIAA SpoIIIAA 28.0 0.0 1.0 0.0025608995046562 0.0278976566226935 0.0152292780636748 0.0253367571180373 0 0 0 0 K06391 0.0 0.0655270655270655 spoIIIAB; stage III sporulation protein AB 139.0 23.0 0.0 1.0 1.0 S 0.0 23.0 2.0 0.956521739130435 2CEWW 23.0 0.0 1.0 0.0044981490404303 0.0267677489079323 0.0156329489741813 0.022269599867502 0 0 0 0 K06392 0.0 0.0797720797720797 spoIIIAC; stage III sporulation protein AC 64.0 27.0 0.0 1.0 1.0 S 0.0 28.0 2.0 0.964285714285714 2E555 28.0 0.0 1.0 0.0024927863004656 0.0302220624154911 0.0163574243579783 0.0277292761150255 0 0 0 0 K06393 0.0 0.0769230769230769 spoIIIAD; stage III sporulation protein AD 126.0 27.0 0.0 1.0 1.0 S 0.0 27.0 3.0 0.925925925925926 2CPUI 27.0 0.0 1.0 0.0028161973521009 0.018034882452953 0.0104255399025269 0.0152186851008521 0 0 0 0 K06394 0.0 0.0769230769230769 spoIIIAE; stage III sporulation protein AE 329.0 27.0 0.0 1.0 1.0 S 0.0 27.0 1.0 1.0 2C2CG 27.0 0.0 1.0 0.0017937493171749 0.0064478612379159 0.0041208052775454 0.004654111920741 0 0 0 0 K06395 0.0 0.0655270655270655 spoIIIAF; stage III sporulation protein AF 110.0 23.0 0.0 1.0 1.0 S 0.0 23.0 9.0 0.478260869565217 2E7KE 23.0 0.0 1.0 0.003883599256075 0.0483655212389611 0.026124560247518 0.0444819219828861 0 0 0 0 K06396 0.0 0.0769230769230769 spoIIIAG; stage III sporulation protein AG 127.0 27.0 0.0 1.0 1.0 S 0.0 27.0 1.0 1.0 2E6BB 27.0 0.0 1.0 0.0015512131930391 0.004712234954117 0.003131724073578 0.0031610217610779 0 0 0 0 K06397 0.0 0.074074074074074 spoIIIAH; stage III sporulation protein AH 114.0 26.0 0.0 1.0 1.0 S 0.0 26.0 6.0 0.615384615384615 2E3US 26.0 0.0 1.0 0.0012667022319504 0.006027958533191 0.0036473303825707 0.0047612563012406 0 0 0 0 K06398 0.0028571428571428 0.0911680911680911 spoIVA; stage IV sporulation protein A 478.0 19.0 9.0 6.0 0.558823529411765 S 1.0 33.0 5.0 0.470588235294118 COG0699 Replication_fork_clamp-binding_protein_CrfC_(dynamin-like_GTPase_family) CrfC 34.0 0.0294117647058823 0.9705882352941176 0.0067737913338613 0.0174861288724835 0.0121299601031724 0.0107123375386221 0 0 0 0 K06399 0.0 0.1082621082621082 spoIVB; stage IV sporulation protein B [EC:3.4.21.116] 103.0 31.0 26.0 4.0 0.75609756097561 M 0.0 44.0 5.0 0.545454545454545 COG0750 Membrane-associated_protease_RseP,_regulator_of_RpoE_activity RseP 44.0 0.0 1.0 0.003587272019774 0.0085847520927592 0.0060860120562666 0.0049974800729852 0 0 0 0 K06400 0.0 0.0 spoIVCA; site-specific DNA recombinase 160.0 151.0 3.0 0.909090909090909 L 0.0 0.0 3.0 0.909090909090909 COG1961 Site-specific_DNA_recombinase_SpoIVCA/DNA_invertase_PinE SpoIVCA 0.0 0 0 0 0 K06401 0.0 0.0341880341880341 spoIVFA; stage IV sporulation protein FA 166.0 7.0 2.0 2.0 0.583333333333333 M 0.0 12.0 3.0 0.583333333333333 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 12.0 0.0 1.0 0.0253728097640352 0.0555953982104312 0.0404841039872332 0.0302225884463959 0 0 0 0 K06402 0.0028571428571428 0.1965811965811965 spoIVFB; stage IV sporulation protein FB [EC:3.4.24.-] 100.0 73.0 70.0 2.0 0.960526315789473 S 1.0 74.0 2.0 0.671052631578947 COG1994 Zn-dependent_protease_(includes_sporulation_protein_SpoIVFB) SpoIVFB 75.0 0.0133333333333333 0.9866666666666668 0.0650989722116533 0.731879048613499 0.3984890104125761 0.6667800764018457 0 0 0 0 K06403 0.0 0.0313390313390313 spoVAA; stage V sporulation protein AA 203.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 28PNE 11.0 0.0 1.0 5.74832726501093e-05 0.144947669665043 0.0725025764688465 0.1448901863923928 0 0 0 0 K06404 0.0 0.0284900284900284 spoVAB; stage V sporulation protein AB 138.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 2AF43 10.0 0.0 1.0 8.35046229683552e-05 0.163875990057721 0.0819797473403446 0.1637924854347526 0 0 0 0 K06405 0.0 0.0826210826210826 spoVAC; stage V sporulation protein AC 133.0 31.0 0.0 1.0 1.0 S 0.0 31.0 1.0 1.0 2ANER 31.0 0.0 1.0 0.0039825787609384 0.0212096759474248 0.0125961273541816 0.0172270971864864 0 0 0 0 K06406 0.0 0.0854700854700854 spoVAD; stage V sporulation protein AD 291.0 32.0 0.0 1.0 1.0 I 0.0 32.0 3.0 0.5 COG0183 Acetyl-CoA_acetyltransferase PaaJ 32.0 0.0 1.0 0.002751909644955 0.0165823654422357 0.0096671375435953 0.0138304557972807 0 0 0 0 K06407 0.0 0.0826210826210826 spoVAE; stage V sporulation protein AE 112.0 38.0 0.0 1.0 1.0 S 0.0 38.0 2.0 0.815789473684211 2ANER 38.0 0.0 1.0 0.004766161745246 0.0427130554877277 0.0237396086164868 0.0379468937424817 0 0 0 0 K06408 0.0 0.0484330484330484 spoVAF; stage V sporulation protein AF 455.0 19.0 0.0 1.0 1.0 EG 0.0 19.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 19.0 0.0 1.0 0.0090209833167634 0.0576865907206883 0.0333537870187258 0.0486656074039248 0 0 0 0 K06409 0.0142857142857142 0.1139601139601139 spoVB; stage V sporulation protein B 367.0 62.0 0.0 1.0 1.0 S 5.0 57.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 62.0 0.0806451612903225 0.9193548387096774 0.0107289878324622 0.146964669547594 0.0788468286900281 0.1362356817151317 0 0 0 0 K06410 0.0028571428571428 0.0797720797720797 spoVFA; dipicolinate synthase subunit A 93.0 18.0 12.0 4.0 0.6 E 1.0 29.0 5.0 0.4 COG0287 Prephenate_dehydrogenase TyrA 30.0 0.0333333333333333 0.9666666666666668 0.0241246281727142 0.349708421862788 0.1869165250177511 0.3255837936900738 0 0 0 0 K06411 0.0085714285714285 0.0541310541310541 spoVFB; dipicolinate synthase subunit B 190.0 17.0 12.0 2.0 0.772727272727273 H 3.0 19.0 2.0 0.772727272727273 COG0452 Phosphopantothenoylcysteine_synthetase/decarboxylase_CoaBC CoaBC 22.0 0.1363636363636363 0.8636363636363636 0.0068136621657306 0.362364699207237 0.1845891806864838 0.3555510370415064 0 0 0 0 K06412 0.0228571428571428 0.1794871794871795 spoVG; stage V sporulation protein G 77.0 60.0 43.0 2.0 0.779220779220779 D 8.0 69.0 1.0 1.0 COG2088 DNA-binding_protein_SpoVG,_cell_septation_regulator SpoVG 77.0 0.1038961038961039 0.8961038961038961 0.224982546129566 0.53278484578071 0.378883695955138 0.3078022996511439 0 0 0 0 K06413 0.0 0.0541310541310541 spoVK; stage V sporulation protein K 252.0 19.0 0.0 1.0 1.0 O 0.0 19.0 1.0 1.0 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 19.0 0.0 1.0 0.0148516447232481 0.190353863983257 0.1026027543532525 0.1755022192600089 0 0 0 0 K06415 0.1171428571428571 0.1538461538461538 spoVR; stage V sporulation protein R 345.0 63.0 26.0 2.0 0.63 S 42.0 58.0 2.0 0.97 COG2719 Stage_V_sporulation_protein_SpoVR/YcgB,_involved_in_spore_cortex_formation_(function_unknown) SpoVR 100.0 0.42 0.58 0.011672284370971 0.157753013477355 0.084712648924163 0.1460807291063839 0 0 0 0 K06416 0.0 0.1481481481481481 spoVS; stage V sporulation protein S 86.0 64.0 0.0 1.0 1.0 S 0.0 64.0 1.0 1.0 COG2359 Stage_V_sporulation_protein_SpoVS,_predicted_DNA-binding,_AlbA_superfamily SpoVS 64.0 0.0 1.0 0.209097292328609 0.906990605331299 0.558043948829954 0.6978933130026901 0 0 0 0 K06417 0.0 0.0227920227920227 spoVID; stage VI sporulation protein D 263.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG1388 LysM_repeat LysM 8.0 0.0 1.0 0.0050125165191507 0.007051597087014 0.0060320568030823 0.0020390805678633 0 0 0 0 K06418 0.0 0.0313390313390313 SASP-A, sspA; small acid-soluble spore protein A (major alpha-type SASP) 65.0 14.0 0.0 1.0 1.0 S 0.0 14.0 2.0 0.928571428571429 2BX75 14.0 0.0 1.0 0.0002488398869486 0.0385815398829332 0.0194151898849408 0.0383326999959846 0 0 0 0 K06419 0.0 0.0284900284900284 SASP-B, sspB; small acid-soluble spore protein B (major beta-type SASP) 62.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 2BX75 14.0 0.0 1.0 0.0003338231425342 0.0351226693899422 0.0177282462662381 0.034788846247408 0 0 0 0 K06420 0.0 0.0113960113960113 sspC; small acid-soluble spore protein C (minor alpha/beta-type SASP) 64.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 2BX75 6.0 0.0 1.0 0.0005920328700188 0.04922419805469 0.0249081154623544 0.0486321651846712 0 0 0 0 K06421 0.0 0.0313390313390313 sspD; small acid-soluble spore protein D (minor alpha/beta-type SASP) 66.0 20.0 0.0 1.0 1.0 S 0.0 20.0 2.0 0.95 2BX75 20.0 0.0 1.0 0.000527875537679 0.0431097972663164 0.0218188364019977 0.0425819217286373 0 0 0 0 K06422 0.0 0.0028490028490028 sspE; small acid-soluble spore protein E (minor gamma-type SASP) 60.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DQAQ 1.0 0.0 1.0 0 0 0 0 K06423 0.0 0.0398860398860398 sspF; small acid-soluble spore protein F (minor alpha/beta-type SASP) 53.0 13.0 0.0 1.0 1.0 S 0.0 14.0 2.0 0.857142857142857 2E2ZT 14.0 0.0 1.0 0.0057140889217306 0.047736426402143 0.0267252576619368 0.0420223374804124 0 0 0 0 K06425 0.0 0.0284900284900284 sspH; small acid-soluble spore protein H (minor) 55.0 10.0 0.0 1.0 1.0 S 0.0 10.0 5.0 0.3 2BBIN 10.0 0.0 1.0 0.0050304319273141 0.0615189575411526 0.0332746947342333 0.0564885256138385 0 0 0 0 K06426 0.0 0.0284900284900284 sspI; small acid-soluble spore protein I (minor) 67.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 2E3SP 10.0 0.0 1.0 0.000127194869319 0.0003592621795012 0.0002432285244101 0.0002320673101822 0 0 0 0 K06428 0.0 0.0028490028490028 sspK; small acid-soluble spore protein K (minor) 51.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2ERTV 1.0 0.0 1.0 0 0 0 0 K06429 0.0 0.0028490028490028 sspL; small acid-soluble spore protein L (minor) 46.0 0.0 1.0 1.0 1.0 2EKFC 1.0 0.0 1.0 0 0 0 0 K06431 0.0 0.0028490028490028 sspN; small acid-soluble spore protein N (minor) 47.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2EPWV 1.0 0.0 1.0 0 0 0 0 K06433 0.0 0.0056980056980056 sspP, cotL; small acid-soluble spore protein P (minor) 50.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EIXB 2.0 0.0 1.0 0 0 0 0 K06434 0.0 0.0256410256410256 tlp; small acid-soluble spore protein (thioredoxin-like protein) 68.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 2E62M 9.0 0.0 1.0 0.0134562371836112 0.0588217313528399 0.0361389842682255 0.0453654941692287 0 0 0 0 K06436 0.0 0.0427350427350427 yabG; spore coat assemly protein 237.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 28HCB 16.0 0.0 1.0 9.56255174129412e-05 0.048121734958873 0.0241086802381429 0.04802610944146 0 0 0 0 K06438 0.0 0.131054131054131 yqfD; similar to stage IV sporulation protein 53.0 24.0 7.0 4.0 0.5 S 0.0 48.0 2.0 0.541666666666667 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 48.0 0.0 1.0 0.0087999333624924 0.0640611276671872 0.0364305305148398 0.0552611943046948 0 0 0 0 K06439 0.0 0.0085470085470085 yraD; similar to spore coat protein 85.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG5577 Spore_coat_protein_CotF CotF 4.0 0.0 1.0 0.0212673018916147 0.0283095244176545 0.0247884131546346 0.0070422225260397 0 0 0 0 K06440 0.0 0.0085470085470085 yraG; similar to spore coat protein 63.0 2.0 0.0 1.0 1.0 S 0.0 6.0 2.0 0.5 2DA30 6.0 0.0 1.0 6.93283141023236e-10 2.78955719016116e-05 1.3948132592376312e-05 2.789487861847058e-05 0 0 0 0 K06441 0.0 0.0142450142450142 E1.12.7.2G; ferredoxin hydrogenase gamma subunit [EC:1.12.7.2] 539.0 6.0 0.0 1.0 1.0 C 0.0 6.0 2.0 0.833333333333333 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 6.0 0.0 1.0 0.0219804783922082 0.0795888453607635 0.0507846618764858 0.0576083669685552 0 0 0 0 K06442 0.1 0.6125356125356125 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227] 150.0 220.0 190.0 4.0 0.869565217391304 J 35.0 218.0 2.0 0.992094861660079 COG1189 Predicted_rRNA_methylase_YqxC,_contains_S4_and_FtsJ_domains YqxC 253.0 0.1383399209486166 0.8616600790513834 0.069591547948444 0.941161393863583 0.5053764709060135 0.871569845915139 0 0 0 0 K06443 0.0085714285714285 0.0797720797720797 lcyB, crtL1, crtY; lycopene beta-cyclase [EC:5.5.1.19] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 193.0 17.0 1.0 2.0 0.515151515151515 CH 3.0 30.0 2.0 0.515151515151515 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 33.0 0.0909090909090909 0.9090909090909092 0.014372609277339 0.0472179084657609 0.0307952588715499 0.0328452991884219 0 0 0 0 K06444 0.0142857142857142 0.017094017094017 lcyE, crtL2; lycopene epsilon-cyclase [EC:5.5.1.18] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 283.0 11.0 0.0 1.0 1.0 C 5.0 6.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 11.0 0.4545454545454545 0.5454545454545454 0.339568625403004 0.312407509852586 0.325988067627795 0.027161115550418 0 0 0 0 K06445 0.0 0.0712250712250712 fadE; acyl-CoA dehydrogenase [EC:1.3.99.-] path:map00071,path:map01100,path:map01212 Fatty acid degradation,Metabolic pathways,Fatty acid metabolism 709.0 28.0 27.0 2.0 0.96551724137931 I 0.0 29.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 29.0 0.0 1.0 0.0025790188587198 0.0082968774596099 0.0054379481591648 0.0057178586008901 0 0 0 0 K06446 0.0142857142857142 0.0911680911680911 DCAA; acyl-CoA dehydrogenase [EC:1.3.99.-] path:map00930,path:map01100,path:map01120 Caprolactam degradation,Metabolic pathways,Microbial metabolism in diverse environments 345.0 33.0 26.0 2.0 0.825 I 6.0 34.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 40.0 0.15 0.85 0.0112908121748075 0.0836297108863013 0.0474602615305544 0.0723388987114938 0 0 0 0 K06447 0.0 0.0598290598290598 astD; succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 437.0 23.0 22.0 2.0 0.958333333333333 C 0.0 24.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 24.0 0.0 1.0 0.0389803591367266 0.0801349470373767 0.0595576530870516 0.04115458790065 0 0 0 0 K06518 0.0314285714285714 0.2022792022792023 cidA; holin-like protein 83.0 87.0 0.0 1.0 1.0 S 11.0 76.0 1.0 1.0 COG1380 Putative_effector_of_murein_hydrolase_LrgA,_UPF0299_family YohJ 87.0 0.1264367816091954 0.8735632183908046 0.0051730516053352 0.0458974094058889 0.025535230505612 0.0407243578005536 0 0 0 0 K06560 0.0028571428571428 0.0 MRC, CD206, CD280; mannose receptor, C type path:map04145,path:map05152 Phagosome,Tuberculosis 533.0 2.0 0.0 1.0 1.0 TV 2.0 0.0 1.0 1.0 KOG4297 2.0 1.0 0.0 0 0 0 0 K06569 0.0285714285714285 0.0 MFI2, CD228; melanoma-associated antigen p97 361.0 10.0 0.0 1.0 1.0 P 10.0 0.0 1.0 1.0 28KI0 10.0 1.0 0.0 0.018364494557509 0.0358600955033067 0.0271122950304078 0.0174956009457977 0 0 0 0 K06572 0.0 0.0028490028490028 PLXNC, CD232; plexin C path:map04360 Axon guidance 25.0 2.0 0.0 1.0 1.0 Z 0.0 2.0 1.0 1.0 COG5069 2.0 0.0 1.0 0 0 0 0 K06580 0.0171428571428571 0.0142450142450142 SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh 325.0 10.0 9.0 2.0 0.909090909090909 P 6.0 5.0 1.0 1.0 COG0004 Ammonia_channel_protein_AmtB AmtB 11.0 0.5454545454545454 0.4545454545454545 0.0733526027424614 0.218068203942061 0.1457104033422612 0.1447156011995996 0 0 0 0 K06595 0.0514285714285714 0.0284900284900284 hemAT; heam-based aerotactic trancducer 280.0 20.0 4.0 3.0 0.540540540540541 NT 22.0 15.0 2.0 0.945945945945946 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 37.0 0.5945945945945946 0.4054054054054054 0.0072577289833526 0.0137310504436579 0.0104943897135052 0.0064733214603053 0 0 0 0 K06596 0.0057142857142857 0.131054131054131 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 105.0 69.0 65.0 7.0 0.851851851851852 T 2.0 65.0 11.0 0.777777777777778 COG0643 Chemotaxis_protein_histidine_kinase_CheA CheA 67.0 0.0298507462686567 0.9701492537313432 0.0412514076301203 0.772707259908669 0.4069793337693946 0.7314558522785487 0 0 0 0 K06597 0.0 0.0142450142450142 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase) path:map02020 Two-component system 302.0 5.0 0.0 1.0 1.0 NT 0.0 5.0 1.0 1.0 COG2201 Chemotaxis_response_regulator_CheB,_contains_REC_and_protein-glutamate_methylesterase_domains CheB 5.0 0.0 1.0 0.0148409460319639 0.0373099236379386 0.0260754348349512 0.0224689776059747 0 0 0 0 K06598 0.0 0.0142450142450142 chpC; chemosensory pili system protein ChpC path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 153.0 5.0 0.0 1.0 1.0 NT 0.0 5.0 1.0 1.0 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 5.0 0.0 1.0 2.55084180825407e-09 2.50918225162437e-07 1.2673453348534554e-07 2.4836738335418294e-07 0 0 0 0 K06599 0.0 0.0028490028490028 chpD; AraC family transcriptional regulator, chemosensory pili system protein ChpD 251.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K06600 0.0028571428571428 0.017094017094017 chpE; chemosensory pili system protein ChpE 195.0 7.0 0.0 1.0 1.0 E 1.0 6.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 7.0 0.1428571428571428 0.8571428571428571 0.0758766953437052 0.201091129915492 0.1384839126295985 0.1252144345717868 0 0 0 0 K06601 0.0 0.0512820512820512 flbT; flagellar biosynthesis repressor protein FlbT 112.0 23.0 0.0 1.0 1.0 N 0.0 23.0 1.0 1.0 COG5443 Flagellar_biosynthesis_regulator_FlbT FlbT 23.0 0.0 1.0 0.0096148727330043 0.0114205001930693 0.0105176864630368 0.001805627460065 0 0 0 0 K06602 0.0 0.0512820512820512 flaF; flagellar biosynthesis activator protein FlaF 97.0 23.0 0.0 1.0 1.0 N 0.0 23.0 1.0 1.0 COG5442 Flagellar_biosynthesis_regulator_FlaF FlaF 23.0 0.0 1.0 0.0081222058450555 0.0156199396378632 0.0118710727414593 0.0074977337928077 0 0 0 0 K06603 0.0 0.2165242165242165 flaG; flagellar protein FlaG 52.0 75.0 0.0 1.0 1.0 N 0.0 76.0 2.0 0.986842105263158 COG1334 Uncharacterized_conserved_protein,_FlaG/YvyC_family FlaG 76.0 0.0 1.0 0.0492831393271818 0.102916169688535 0.0760996545078584 0.0536330303613531 0 0 0 0 K06604 0.0 0.0028490028490028 flaI; flagellar protein FlaI 96.0 0.0 1.0 1.0 1.0 2AWMQ 1.0 0.0 1.0 0 0 0 0 K06605 0.0 0.0284900284900284 iolH; myo-inositol catabolism protein IolH 277.0 12.0 0.0 1.0 1.0 G 0.0 12.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 12.0 0.0 1.0 0.042893957630507 0.0884509756672942 0.0656724666489006 0.0455570180367871 0 0 0 0 K06606 0.0085714285714285 0.0541310541310541 iolI; 2-keto-myo-inositol isomerase [EC:5.3.99.11] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 173.0 24.0 22.0 2.0 0.923076923076923 G 3.0 23.0 2.0 0.769230769230769 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 26.0 0.1153846153846153 0.8846153846153846 0.841857090946795 0.187434259692983 0.5146456753198889 0.654422831253812 0 0 1 1 K06607 0.0 0.017094017094017 iolS; myo-inositol catabolism protein IolS [EC:1.1.1.-] 309.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 6.0 0.0 1.0 0.0206654737823771 0.0277436184681131 0.0242045461252451 0.007078144685736 0 0 0 0 K06608 0.0 0.0113960113960113 iolR; DeoR family transcriptional regulator, myo-inositol catabolism operon repressor 248.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 6.0 0.0 1.0 0.0169471223254327 0.0309879183888889 0.0239675203571608 0.0140407960634562 0 0 0 0 K06609 0.0 0.0113960113960113 iolT; MFS transporter, SP family, major inositol transporter 458.0 5.0 4.0 2.0 0.833333333333333 EGP 0.0 6.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 6.0 0.0 1.0 0 0 0 0 K06610 0.02 0.017094017094017 iolF; MFS transporter, SP family, inositol transporter 400.0 7.0 1.0 2.0 0.538461538461538 G 7.0 6.0 3.0 0.461538461538462 arCOG02684 13.0 0.5384615384615384 0.4615384615384615 0.0505903966828248 0.104813161341875 0.0777017790123499 0.0542227646590502 0 0 0 0 K06626 0.0028571428571428 0.0 CCNE; G1/S-specific cyclin-E1 path:map04110,path:map04114,path:map04115,path:map04151,path:map04218,path:map04391,path:map04934,path:map05161,path:map05162,path:map05165,path:map05166,path:map05169,path:map05200,path:map05203,path:map05206,path:map05215,path:map05222,path:map05226 Cell cycle,Oocyte meiosis,p53 signaling pathway,PI3K-Akt signaling pathway,Cellular senescence,Hippo signaling pathway - fly,Cushing syndrome,Hepatitis B,Measles,Human papillomavirus infection,Human T-cell leukemia virus 1 infection,Epstein-Barr virus infection,Pathways in cancer,Viral carcinogenesis,MicroRNAs in cancer,Prostate cancer,Small cell lung cancer,Gastric cancer 830.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG1524 c-di-AMP_phosphodiesterase_AtaC_or_nucleotide_pyrophosphatase,_AlkP_superfamily AtaC 1.0 1.0 0.0 0 0 0 0 K06634 0.0028571428571428 0.0 CCNH; cyclin H path:map03022,path:map03420,path:map04110 Basal transcription factors,Nucleotide excision repair,Cell cycle 169.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 1.0 1.0 0.0 0 0 0 0 K06653 0.0 0.0028490028490028 PHO81; CDK inhibitor PHO81 path:map04111 Cell cycle - yeast 205.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG0584 Glycerophosphoryl_diester_phosphodiesterase UgpQ 1.0 0.0 1.0 0 0 0 0 K06666 0.0028571428571428 0.0 TUP1; general transcriptional corepressor TUP1 path:map04011,path:map04111 MAPK signaling pathway - yeast,Cell cycle - yeast 382.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0266 1.0 1.0 0.0 0 0 0 0 K06669 0.0085714285714285 0.0 SMC3, CSPG6; structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) path:map04110,path:map04111,path:map04113,path:map04114 Cell cycle,Cell cycle - yeast,Meiosis - yeast,Oocyte meiosis 601.0 4.0 0.0 1.0 1.0 D 4.0 0.0 1.0 1.0 COG1196 Chromosome_segregation_ATPase_Smc Smc 4.0 1.0 0.0 0.0299576018506156 0.0970988152908093 0.0635282085707124 0.0671412134401936 0 0 0 0 K06674 0.0085714285714285 0.0 SMC2; structural maintenance of chromosome 2 path:map04111 Cell cycle - yeast 53.0 2.0 1.0 2.0 0.666666666666667 BD 3.0 0.0 2.0 0.666666666666667 COG1196 Chromosome_segregation_ATPase_Smc Smc 3.0 1.0 0.0 0 0 0 0 K06688 0.0085714285714285 0.0 UBE2C, UBC11; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23] path:map04120 Ubiquitin mediated proteolysis 155.0 3.0 0.0 1.0 1.0 O 3.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 3.0 1.0 0.0 0 0 0 0 K06689 0.0085714285714285 0.0 UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23] path:map04013,path:map04120,path:map04141,path:map04624,path:map05131 MAPK signaling pathway - fly,Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum,Toll and Imd signaling pathway,Shigellosis 135.0 3.0 0.0 1.0 1.0 O 3.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 3.0 1.0 0.0 0 0 0 0 K06714 0.0 0.0683760683760683 rocR; arginine utilization regulatory protein 274.0 88.0 65.0 2.0 0.792792792792793 KT 0.0 111.0 7.0 0.936936936936937 COG3829 RocR-type_transcriptional_regulator,_contains_PAS,_AAA-type_ATPase,_and_DNA-binding_Fis_domains RocR 111.0 0.0 1.0 0.0003021345214311 0.0110010737862007 0.0056516041538159 0.0106989392647696 0 0 0 0 K06718 0.0685714285714285 0.1168091168091168 ectA; L-2,4-diaminobutyric acid acetyltransferase [EC:2.3.1.178] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 70.0 37.0 19.0 5.0 0.569230769230769 K 24.0 41.0 4.0 0.584615384615385 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 65.0 0.3692307692307692 0.6307692307692307 0.006143129112475 0.0220558197677427 0.0140994744401088 0.0159126906552677 0 0 0 0 K06720 0.06 0.1168091168091168 ectC; L-ectoine synthase [EC:4.2.1.108] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 81.0 30.0 12.0 5.0 0.476190476190476 S 23.0 41.0 3.0 0.921875 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 64.0 0.359375 0.640625 0.0396321851330859 0.267657567107682 0.1536448761203839 0.2280253819745961 0 0 0 0 K06726 0.0057142857142857 0.1139601139601139 rbsD; D-ribose pyranase [EC:5.4.99.62] path:map02010 ABC transporters 100.0 34.0 27.0 3.0 0.790697674418605 G 2.0 41.0 2.0 0.953488372093023 COG1869 D-ribose_pyranose/furanose_isomerase_RbsD RbsD 43.0 0.0465116279069767 0.9534883720930232 0.17273665851499 0.0933151993470674 0.1330259289310287 0.0794214591679226 0 0 0 0 K06857 0.2742857142857143 0.1851851851851851 tupC, vupC; tungstate transport system ATP-binding protein [EC:7.3.2.6] path:map02010 ABC transporters 114.0 66.0 3.0 5.0 0.379310344827586 E 104.0 70.0 10.0 0.264367816091954 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 174.0 0.5977011494252874 0.4022988505747126 0.7223465486527 0.867628826827689 0.7949876877401945 0.145282278174989 0 1 0 1 K06858 0.0 0.0427350427350427 btuF; vitamin B12 transport system substrate-binding protein path:map02010 ABC transporters 260.0 15.0 0.0 1.0 1.0 P 0.0 15.0 1.0 1.0 COG0614 ABC-type_Fe3+-hydroxamate_transport_system,_periplasmic_component FepB 15.0 0.0 1.0 0.0096521800163216 0.0242001987859498 0.0169261894011357 0.0145480187696282 0 0 0 0 K06859 0.2057142857142857 0.037037037037037 pgi1; glucose-6-phosphate isomerase, archaeal [EC:5.3.1.9] path:map00010,path:map00030,path:map00500,path:map00520,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 130.0 87.0 86.0 2.0 0.988636363636364 G 73.0 15.0 1.0 1.0 COG2140 Oxalate_decarboxylase/archaeal_phosphoglucose_isomerase,_cupin_superfamily OxdD 88.0 0.8295454545454546 0.1704545454545454 0.0278654503490217 0.422322983884818 0.2250942171169198 0.3944575335357962 0 0 0 0 K06860 0.0 0.017094017094017 K06860; putative heme uptake system protein 143.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG1432 NYN_domain,_predicted_PIN-related_RNAse,_tRNA/rRNA_maturation LabA 6.0 0.0 1.0 0.0495348018936118 0.126609857590035 0.0880723297418234 0.0770750556964232 0 0 0 0 K06861 0.0257142857142857 0.6096866096866097 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] path:map02010 ABC transporters 224.0 220.0 212.0 3.0 0.956521739130435 S 10.0 220.0 2.0 0.965217391304348 COG1137 ABC-type_lipopolysaccharide_export_system,_ATPase_component LptB 230.0 0.0434782608695652 0.9565217391304348 0.0734754657184992 0.0455295338311229 0.059502499774811 0.0279459318873762 0 0 0 0 K06862 0.1257142857142857 0.0 ehbQ; energy-converting hydrogenase B subunit Q 202.0 45.0 0.0 1.0 1.0 S 48.0 0.0 1.0 1.0 COG1707 Uncharacterized_protein,_contains_ACT_and_PBP-like_DUF5612_domains,_MJ1458_family AF1403 48.0 1.0 0.0 0.0105836465347788 0.142503724214577 0.0765436853746779 0.1319200776797982 0 0 0 0 K06863 0.4057142857142857 0.0142450142450142 purP; 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase [EC:6.3.4.23] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 244.0 273.0 0.0 1.0 1.0 F 263.0 10.0 1.0 1.0 COG1759 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl_5'-monophosphate_synthetase_(purine_biosynthesis) PurP 273.0 0.9633699633699634 0.0366300366300366 0.942029653499623 0.981647866821519 0.961838760160571 0.039618213321896 1 1 1 1 K06864 0.4571428571428571 0.3903133903133903 larE; pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase [EC:4.4.1.37] 64.0 237.0 152.0 4.0 0.716012084592145 S 193.0 149.0 5.0 0.780701754385965 COG1606 ATP-utilizing_enzyme,_PP-loop_superfamily 342.0 0.564327485380117 0.435672514619883 0.0906915893391221 0.820200670537542 0.455446129938332 0.7295090811984198 0 0 0 0 K06865 0.7257142857142858 0.0 K06865; ATPase 426.0 228.0 202.0 3.0 0.873563218390805 V 260.0 0.0 1.0 1.0 COG1855 Predicted_ATPase,_PilT_family,_contains_N-terminal_PIN_domain PilT 260.0 1.0 0.0 0.961119574541586 0.468835617074296 0.714977595807941 0.49228395746729 0 0 1 1 K06866 0.0 0.0113960113960113 grcA; autonomous glycyl radical cofactor 125.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG3445 Autonomous_glycyl_radical_cofactor_GrcA GrcA 4.0 0.0 1.0 2.47161991962122e-12 2.83852905383519e-08 1.4193881079135762e-08 2.838281891843228e-08 0 0 0 0 K06867 0.02 0.188034188034188 K06867; uncharacterized protein 10.0 69.0 24.0 8.0 0.547619047619048 S 10.0 107.0 3.0 0.96031746031746 COG0666 Ankyrin_repeat ANKYR 117.0 0.0854700854700854 0.9145299145299144 0.0238005315364485 0.0245888358812908 0.0241946837088696 0.0007883043448423 0 0 0 0 K06868 0.2228571428571428 0.0 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73] path:map00970 Aminoacyl-tRNA biosynthesis 344.0 96.0 0.0 1.0 1.0 J 104.0 0.0 2.0 0.923076923076923 COG1103 Archaeal_Cys-tRNA_synthase_(O-phospho-L-seryl-tRNA:Cys-tRNA_synthase) 104.0 1.0 0.0 0.967267782290752 0.947548857662224 0.957408319976488 0.019718924628528 0 0 1 1 K06869 0.7657142857142857 0.0 K06869; uncharacterized protein 93.0 392.0 0.0 1.0 1.0 S 392.0 0.0 1.0 1.0 COG1938 Predicted_ATP-dependent_carboligase,_ATP-grasp_superfamily 392.0 1.0 0.0 0.668473686021861 0.21512386518978 0.4417987756058205 0.453349820832081 0 0 0 1 K06870 0.3628571428571429 0.0028490028490028 K06870; uncharacterized protein 81.0 116.0 72.0 2.0 0.725 O 157.0 2.0 2.0 0.9875 COG1750 Predicted_archaeal_serine_protease,_S18_family 159.0 0.9874213836477987 0.0125786163522012 0.971941039880451 0.849806802069208 0.9108739209748296 0.122134237811243 0 0 1 1 K06871 0.1914285714285714 0.3162393162393162 K06871; uncharacterized protein 28.0 310.0 299.0 5.0 0.930930930930931 C 120.0 209.0 2.0 0.972972972972973 COG0641 Sulfatase_maturation_enzyme_AslB,_radical_SAM_superfamily AslB 329.0 0.364741641337386 0.6352583586626139 0.104865099905469 0.0467181305095984 0.0757916152075336 0.0581469693958705 0 0 0 0 K06872 0.0285714285714285 0.3247863247863248 K06872; uncharacterized protein 84.0 154.0 0.0 1.0 1.0 S 11.0 142.0 2.0 0.993506493506494 COG1512 Uncharacterized_membrane_protein_YgcG,_contains_a_TPM-fold_domain YgcG 153.0 0.0718954248366013 0.9281045751633988 0.0001422918801366 0.0938923895738396 0.0470173407269881 0.0937500976937029 0 0 0 0 K06873 0.2314285714285714 0.0968660968660968 K06873; uncharacterized protein 230.0 129.0 0.0 1.0 1.0 C 87.0 42.0 1.0 1.0 COG0857 BioD-like_N-terminal_domain_of_phosphotransacetylase PtaN 129.0 0.6744186046511628 0.3255813953488372 0.652616177560199 0.788630118580958 0.7206231480705785 0.136013941020759 0 1 0 1 K06874 0.4485714285714285 0.0 K06874; zinc finger protein 107.0 159.0 0.0 1.0 1.0 S 159.0 0.0 1.0 1.0 COG1779 C4-type_Zn-finger_protein Zpr1 159.0 1.0 0.0 0.344538473801768 0.435353177813602 0.389945825807685 0.090814704011834 0 0 0 0 K06875 0.7571428571428571 0.0 PDCD5, TFAR19; programmed cell death protein 5 59.0 138.0 10.0 2.0 0.518796992481203 S 266.0 0.0 1.0 1.0 COG2118 DNA-binding_TFAR19-related_protein,_PDSD5_family PDCD5 266.0 1.0 0.0 0.168559819589945 0.327736473147184 0.2481481463685645 0.159176653557239 0 0 0 0 K06876 0.0914285714285714 0.1823361823361823 phrB; (6-4)DNA photolyase [EC:4.1.99.13] 323.0 103.0 0.0 1.0 1.0 S 36.0 67.0 1.0 1.0 COG3046 Uncharacterized_conserved_protein_related_to_deoxyribodipyrimidine_photolyase 103.0 0.3495145631067961 0.6504854368932039 0.0149644972568254 0.0490906272623096 0.0320275622595675 0.0341261300054842 0 0 0 0 K06877 0.4228571428571429 0.3361823361823361 K06877; DEAD/DEAH box helicase domain-containing protein 117.0 338.0 327.0 6.0 0.94150417827298 L 203.0 147.0 13.0 0.604456824512535 COG1205 ATP-dependent_helicase_YprA,__contains_C-terminal_metal-binding_DUF1998_domain YprA 350.0 0.58 0.42 0.301612091182502 0.948540668509482 0.625076379845992 0.6469285773269801 0 0 0 0 K06878 0.2942857142857142 0.3447293447293447 K06878; tRNA-binding protein 80.0 238.0 233.0 3.0 0.967479674796748 J 114.0 132.0 4.0 0.930894308943089 COG0073 tRNA-binding_EMAP/Myf_domain EMAP 246.0 0.4634146341463415 0.5365853658536586 0.947267249105509 0.973251793927208 0.9602595215163584 0.0259845448216989 1 1 1 1 K06879 0.0 0.1139601139601139 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 113.0 22.0 15.0 5.0 0.55 S 0.0 40.0 1.0 1.0 COG0780 NADPH-dependent_7-cyano-7-deazaguanine_reductase_QueF,_C-terminal_domain,_T-fold_superfamily QueFC 40.0 0.0 1.0 0.0112433463899017 0.0357737147956619 0.0235085305927818 0.0245303684057602 0 0 0 0 K06880 0.0371428571428571 0.0313390313390313 ereA_B; erythromycin esterase [EC:3.1.1.-] 210.0 29.0 28.0 3.0 0.935483870967742 S 18.0 13.0 2.0 0.967741935483871 COG2312 Erythromycin_esterase_homolog YbfO 31.0 0.5806451612903226 0.4193548387096774 0.0275928719068375 0.0644543364350701 0.0460236041709538 0.0368614645282326 0 0 0 0 K06881 0.0142857142857142 0.5954415954415955 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 85.0 239.0 234.0 3.0 0.975510204081633 S 5.0 239.0 2.0 0.987755102040816 COG0618 nanoRNase/pAp_phosphatase,_hydrolyzes_c-di-AMP_and_oligoRNAs NrnA 244.0 0.0204918032786885 0.9795081967213116 0.0690305795141489 0.0776760265734485 0.0733533030437987 0.0086454470592996 0 0 0 0 K06882 0.0 0.0484330484330484 K06882; uncharacterized protein 69.0 14.0 11.0 3.0 0.736842105263158 S 0.0 19.0 4.0 0.789473684210526 COG4733 Phage-related_protein,_tail_protein_J 19.0 0.0 1.0 0.0038743695813054 0.0222904597424309 0.0130824146618681 0.0184160901611255 0 0 0 0 K06883 0.8314285714285714 0.1994301994301994 K06883; uncharacterized protein 60.0 578.0 571.0 6.0 0.966555183946488 S 460.0 137.0 11.0 0.881270903010033 COG1100 GTPase_SAR1_family_domain Gem1 597.0 0.7705192629815746 0.2294807370184254 0.219331645968374 0.882085062654055 0.5507083543112145 0.662753416685681 0 0 0 0 K06884 0.0028571428571428 0.0227920227920227 K06884; uncharacterized protein 62.0 13.0 4.0 2.0 0.590909090909091 D 3.0 19.0 1.0 1.0 COG3729 General_stress_protein_YciG,_contains_tandem_KGG_domains GsiB 22.0 0.1363636363636363 0.8636363636363636 4.5515733306267e-12 0.0002078567282805 0.000103928366416 0.0002078567237289 0 0 0 0 K06885 0.7285714285714285 0.2905982905982906 K06885; uncharacterized protein 93.0 456.0 454.0 3.0 0.991304347826087 S 344.0 115.0 2.0 0.995652173913044 COG1078 HD_superfamily_phosphohydrolase YdhJ 459.0 0.7494553376906318 0.2505446623093681 0.160037031550942 0.508618693250626 0.334327862400784 0.348581661699684 0 0 0 0 K06886 0.0914285714285714 0.3361823361823361 glbN; hemoglobin 17.0 174.0 151.0 7.0 0.794520547945205 S 33.0 185.0 9.0 0.936073059360731 COG2346 Truncated_hemoglobin_YjbI YjbI 218.0 0.1513761467889908 0.8486238532110092 0.0085495224025194 0.0173638085364139 0.0129566654694666 0.0088142861338945 0 0 0 0 K06887 0.0057142857142857 0.017094017094017 K06887; uncharacterized protein 49.0 7.0 6.0 2.0 0.875 S 2.0 6.0 1.0 1.0 COG3157 Type_VI_protein_secretion_system_component_Hcp_(secreted_cytotoxin) Hcp 8.0 0.25 0.75 0.0748510838540274 0.289928515268979 0.1823897995615032 0.2150774314149516 0 0 0 0 K06888 0.3942857142857143 0.4757834757834758 K06888; uncharacterized protein 252.0 386.0 385.0 3.0 0.994845360824742 O 189.0 199.0 4.0 0.987113402061856 COG1331 Uncharacterized_conserved_protein_YyaL,_SSP411_family,_contains_thoiredoxin_and_six-hairpin_glycosidase-like_domains YyaL 388.0 0.4871134020618556 0.5128865979381443 0.0024487679196994 0.0232582026331246 0.012853485276412 0.0208094347134252 0 0 0 0 K06889 0.0 0.0 K06889; uncharacterized protein 608.0 557.0 18.0 0.8 S 0.0 0.0 21.0 0.892105263157895 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 0.0 0 0 0 0 K06890 0.0571428571428571 0.2991452991452991 K06890; uncharacterized protein 155.0 103.0 92.0 2.0 0.903508771929825 S 20.0 111.0 2.0 0.870229007633588 COG0670 Integral_membrane_protein_YbhL,_putative_Ca2+_regulator,_Bax_inhibitor_(BI-1)/TMBIM_family YbhL 131.0 0.1526717557251908 0.8473282442748091 0.0030416827792123 0.0822273370166774 0.0426345098979448 0.0791856542374651 0 0 0 0 K06891 0.0 0.4700854700854701 clpS; ATP-dependent Clp protease adaptor protein ClpS 59.0 174.0 159.0 2.0 0.920634920634921 S 0.0 189.0 1.0 1.0 COG2127 ATP-dependent_Clp_protease_adapter_protein_ClpS ClpS 189.0 0.0 1.0 0.0010391982603058 0.0083443053735347 0.0046917518169202 0.0073051071132288 0 0 0 0 K06893 0.0314285714285714 0.1623931623931624 K06893; uncharacterized protein 13.0 90.0 89.0 3.0 0.978260869565217 S 12.0 80.0 4.0 0.891304347826087 COG3631 Ketosteroid_isomerase-related_protein YesE 92.0 0.1304347826086956 0.8695652173913043 0.0402892575536949 0.100324771997081 0.0703070147753879 0.0600355144433861 0 0 0 0 K06894 0.0114285714285714 0.2905982905982906 yfhM; alpha-2-macroglobulin 257.0 106.0 90.0 5.0 0.821705426356589 S 4.0 125.0 6.0 0.922480620155039 COG2373 Uncharacterized_conserved_protein_YfaS,_alpha-2-macroglobulin_family YfaS 129.0 0.0310077519379844 0.9689922480620154 0.0669848536556369 0.932229357782335 0.4996071057189859 0.8652445041266981 0 0 0 0 K06895 0.0342857142857142 0.1994301994301994 lysE, argO; L-lysine exporter family protein LysE/ArgO 156.0 76.0 65.0 2.0 0.873563218390805 S 12.0 75.0 2.0 0.873563218390805 COG1279 Arginine_exporter_protein_ArgO ArgO 87.0 0.1379310344827586 0.8620689655172413 0.0116609451815258 0.216797213812978 0.1142290794972519 0.2051362686314522 0 0 0 0 K06896 0.0 0.0256410256410256 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 252.0 7.0 5.0 2.0 0.777777777777778 L 0.0 9.0 1.0 1.0 COG3568 Metal-dependent_hydrolase,_endonuclease/exonuclease/phosphatase_family ElsH 9.0 0.0 1.0 0.127960040644763 0.63053207452319 0.3792460575839765 0.5025720338784271 0 0 0 0 K06897 0.3942857142857143 0.1937321937321937 K06897; 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 76.0 288.0 268.0 3.0 0.932038834951456 S 219.0 90.0 2.0 0.964401294498382 COG1237 Metal-dependent_hydrolase,_beta-lactamase_superfamily_II 309.0 0.7087378640776699 0.2912621359223301 0.803853053017852 0.846880240861007 0.8253666469394295 0.0430271878431549 1 1 1 1 K06898 0.4228571428571429 0.3076923076923077 larB; pyridinium-3,5-biscarboxylic acid mononucleotide synthase [EC:2.5.1.143] 156.0 260.0 248.0 3.0 0.935251798561151 S 154.0 124.0 3.0 0.942446043165468 COG1691 NCAIR_mutase_(PurE)-related_protein 278.0 0.5539568345323741 0.4460431654676259 0.713363696494486 0.700882141528765 0.7071229190116255 0.012481554965721 0 1 0 1 K06899 0.0 0.0341880341880341 ndpA; nucleoid-associated protein 316.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3081 dsDNA-binding_nucleoid-associated_protein_YejK/NdpA NdpA 13.0 0.0 1.0 1.65677798640173e-12 2.57973991596356e-09 1.2906983469749806e-09 2.578083137977158e-09 0 0 0 0 K06900 0.0 0.0484330484330484 capV; cGAMP-activated phospholipase [EC:3.1.1.32 3.1.1.-] path:map00564,path:map00592,path:map01100,path:map01110 Glycerophospholipid metabolism,alpha-Linolenic acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 219.0 11.0 3.0 3.0 0.55 S 0.0 20.0 1.0 1.0 COG3621 Patatin-like_phospholipase/acyl_hydrolase,_includes_sporulation_protein_CotR PATA 20.0 0.0 1.0 0.0268337562135007 0.0427587267545248 0.0347962414840127 0.0159249705410241 0 0 0 0 K06901 0.2285714285714285 0.4643874643874643 pbuG, azgA, ghxP, ghxQ, adeQ; adenine/guanine/hypoxanthine permease 310.0 222.0 150.0 3.0 0.718446601941748 S 83.0 226.0 3.0 0.932038834951457 COG2252 Xanthine/guanine/uracil/vitamin_C_permease_GhxP/GhxQ,_nucleobase:cation_symporter_2_(_NCS2)_family NCS2 309.0 0.2686084142394822 0.7313915857605178 0.47980965618252 0.575621333457424 0.5277154948199719 0.0958116772749039 0 0 0 0 K06902 0.0857142857142857 0.376068376068376 UMF1; MFS transporter, UMF1 family path:map04138 Autophagy - yeast 303.0 173.0 163.0 2.0 0.945355191256831 S 41.0 142.0 1.0 1.0 COG2270 MFS-type_transporter_involved_in_bile_tolerance,_Atg22_family BtlA 183.0 0.2240437158469945 0.7759562841530054 0.0082486429922647 0.340428097677738 0.1743383703350013 0.3321794546854733 0 0 0 0 K06903 0.0514285714285714 0.131054131054131 K06903; uncharacterized protein 55.0 65.0 0.0 1.0 1.0 S 19.0 60.0 2.0 0.924050632911392 COG3628 Phage_baseplate_assembly_protein_W 79.0 0.240506329113924 0.759493670886076 0.0397569761647428 0.0834417920352845 0.0615993841000136 0.0436848158705416 0 0 0 0 K06904 0.0 0.0911680911680911 K06904; uncharacterized protein 98.0 30.0 25.0 3.0 0.769230769230769 S 0.0 39.0 1.0 1.0 COG3740 Phage_head_maturation_protease 39.0 0.0 1.0 0.0103107216241303 0.0727776996293086 0.0415442106267194 0.0624669780051783 0 0 0 0 K06905 0.02 0.0512820512820512 K06905; uncharacterized protein 210.0 26.0 0.0 1.0 1.0 S 7.0 26.0 1.0 1.0 COG3500 Phage_protein_D gpD 33.0 0.2121212121212121 0.7878787878787878 0.0195013511661331 0.0656260428954059 0.0425636970307694 0.0461246917292728 0 0 0 0 K06906 0.0 0.0199430199430199 K06906; uncharacterized protein 128.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 COG3499 Phage_protein_U 10.0 0.0 1.0 0.0286341518154884 0.0701141781242181 0.0493741649698532 0.0414800263087297 0 0 0 0 K06907 0.0485714285714285 0.168091168091168 K06907; uncharacterized protein 191.0 102.0 101.0 3.0 0.980769230769231 S 18.0 86.0 1.0 1.0 COG3497 Phage_tail_sheath_protein_FI 104.0 0.173076923076923 0.8269230769230769 0.0381579593717975 0.090567351053569 0.0643626552126832 0.0524093916817715 0 0 0 0 K06908 0.0 0.037037037037037 K06908; uncharacterized protein 146.0 17.0 0.0 1.0 1.0 S 0.0 17.0 2.0 0.941176470588235 COG3498 Phage_tail_tube_protein_FII 17.0 0.0 1.0 0.0180820681054204 0.0516517733801158 0.0348669207427681 0.0335697052746954 0 0 0 0 K06909 0.0057142857142857 0.0541310541310541 xtmB; phage terminase large subunit 182.0 18.0 16.0 3.0 0.818181818181818 S 3.0 22.0 2.0 0.88 COG1783 Phage_terminase_large_subunit XtmB 25.0 0.12 0.88 0.0509908468731521 0.116563773571761 0.0837773102224565 0.0655729266986089 0 0 0 0 K06910 0.3828571428571428 0.3561253561253561 PEBP, TFS1; phosphatidylethanolamine-binding protein 53.0 287.0 270.0 5.0 0.908227848101266 S 163.0 154.0 2.0 0.996845425867508 COG1881 Uncharacterized_conserved_protein,_phosphatidylethanolamine-binding_protein_(PEBP)_family PEBP 317.0 0.5141955835962145 0.4858044164037854 0.146230001478255 0.405041166488206 0.2756355839832305 0.258811165009951 0 0 0 0 K06911 0.3285714285714285 0.4729344729344729 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24] 55.0 385.0 350.0 6.0 0.84061135371179 S 139.0 319.0 3.0 0.923580786026201 COG1741 Redox-sensitive_bicupin_YhaK,_pirin_superfamily YhaK 458.0 0.3034934497816594 0.6965065502183406 0.0075670665973155 0.0178240017022328 0.0126955341497741 0.0102569351049172 0 0 0 0 K06912 0.0 0.0142450142450142 tfdA; alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase [EC:1.14.11.-] path:map00361,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Microbial metabolism in diverse environments,Degradation of aromatic compounds 281.0 7.0 6.0 2.0 0.875 Q 0.0 8.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 8.0 0.0 1.0 0.0037359918832139 0.0118206257272525 0.0077783088052332 0.0080846338440386 0 0 0 0 K06913 0.1942857142857142 0.0056980056980056 K06913; uncharacterized protein 191.0 72.0 0.0 1.0 1.0 S 70.0 2.0 1.0 1.0 COG2232 Pyrrolysine_biosynthesis_ligase_PylC_and_related_enzymes,_ATP-grasp_superfamily PylC 72.0 0.9722222222222222 0.0277777777777777 0.953476386935443 0.810685330992784 0.8820808589641135 0.142791055942659 0 0 1 1 K06914 0.1885714285714285 0.0056980056980056 mfnD; tyramine---L-glutamate ligase [EC:6.3.4.24] path:map00680,path:map01100,path:map01240 Methane metabolism,Metabolic pathways,Biosynthesis of cofactors 186.0 56.0 41.0 2.0 0.788732394366197 S 69.0 2.0 1.0 1.0 COG1821 Tyramine-glutamate_ligase_MfnD_(methanofuran_biosynthesis),_ATP-grasp_superfamily MfnD 71.0 0.971830985915493 0.028169014084507 0.193611119956118 0.0122970778296616 0.1029540988928898 0.1813140421264563 0 0 0 0 K06915 0.8942857142857142 0.4415954415954416 herA; DNA double-strand break repair helicase HerA and related ATPase 12.0 629.0 333.0 10.0 0.600190839694657 L 811.0 212.0 3.0 0.977099236641221 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 1023.0 0.7927663734115347 0.2072336265884653 0.171573838961037 0.208729085666333 0.190151462313685 0.0371552467052959 0 0 0 0 K06916 0.0085714285714285 0.2022792022792023 zapE; cell division protein ZapE 188.0 59.0 44.0 3.0 0.719512195121951 S 3.0 79.0 1.0 1.0 COG1485 Cell_division_protein_ZapE_(Z_ring-associated_ATPase),_AFG1_superfamily ZapE 82.0 0.0365853658536585 0.9634146341463414 0.0022983197291637 0.0044120054960282 0.0033551626125959 0.0021136857668645 0 0 0 0 K06917 0.0171428571428571 0.1623931623931624 selU, mnmH; tRNA 2-selenouridine synthase [EC:2.9.1.3] 199.0 37.0 12.0 3.0 0.587301587301587 S 6.0 57.0 1.0 1.0 COG2603 tRNA_2-selenouridine_synthase_SelU,_contains_rhodanese_domain SelU 63.0 0.0952380952380952 0.9047619047619048 0.0221692048202152 0.0292824568516796 0.0257258308359474 0.0071132520314644 0 0 0 0 K06918 0.0 0.074074074074074 K06918; uncharacterized protein 394.0 26.0 0.0 1.0 1.0 S 0.0 26.0 1.0 1.0 COG3106 Ras-like_GTP-binding_stress-induced_protein_YcjX,__DUF463_family YcjX 26.0 0.0 1.0 0.0024803136651931 0.0082679947558752 0.0053741542105341 0.0057876810906821 0 0 0 0 K06919 0.0 0.0 K06919; putative DNA primase/helicase 105.0 25.0 10.0 0.466666666666667 L 0.0 0.0 20.0 0.482608695652174 COG3378 DNA_primase,_phage-_or_plasmid-associated 0.0 0 0 0 0 K06920 0.5485714285714286 0.5185185185185185 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 121.0 215.0 11.0 2.0 0.513126491646778 F 223.0 196.0 1.0 1.0 COG0603 7-cyano-7-deazaguanine_synthase_(queuosine_biosynthesis) QueC 419.0 0.5322195704057279 0.4677804295942721 0.821537122459244 0.787743625486745 0.8046403739729946 0.033793496972499 1 1 1 1 K06921 0.4057142857142857 0.1623931623931624 K06921; uncharacterized protein 37.0 499.0 442.0 5.0 0.826158940397351 S 513.0 110.0 5.0 0.986111111111111 COG1672 Predicted_ATPase,_archaeal_AAA+_ATPase_superfamily 623.0 0.8234349919743178 0.1765650080256821 0.014978207369947 0.79888832262295 0.4069332649964485 0.7839101152530029 0 0 0 0 K06922 0.0914285714285714 0.0683760683760683 K06922; uncharacterized protein 248.0 55.0 39.0 3.0 0.753424657534247 S 39.0 33.0 1.0 1.0 COG1483 Predicted_ATPase,_AAA+_superfamily 72.0 0.5416666666666666 0.4583333333333333 0.132937967792184 0.347048309964781 0.2399931388784825 0.2141103421725969 0 0 0 0 K06923 0.0057142857142857 0.225071225071225 K06923; uncharacterized protein 214.0 72.0 64.0 4.0 0.878048780487805 S 2.0 80.0 1.0 1.0 COG2607 Predicted_ATPase,_AAA+_superfamily Atu1564 82.0 0.024390243902439 0.975609756097561 0.0032928689446755 0.0118216659824256 0.0075572674635505 0.0085287970377501 0 0 0 0 K06924 0.0542857142857142 0.0 K06924; uncharacterized protein 350.0 19.0 0.0 1.0 1.0 S 19.0 0.0 1.0 1.0 COG3044 Predicted_ATPase_of_the_ABC_class 19.0 1.0 0.0 0.0039949039089146 0.0068786582983174 0.0054367811036159 0.0028837543894027 0 0 0 0 K06925 0.0 0.9373219373219374 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE 42.0 321.0 312.0 5.0 0.93859649122807 S 0.0 342.0 4.0 0.961988304093567 COG0802 tRNA_A37_threonylcarbamoyladenosine_biosynthesis_protein_TsaE TsaE 342.0 0.0 1.0 0.0230142057539306 0.24948692576305 0.1362505657584903 0.2264727200091194 0 0 0 0 K06926 0.0771428571428571 0.1139601139601139 K06926; uncharacterized protein 103.0 58.0 30.0 2.0 0.674418604651163 S 33.0 53.0 1.0 1.0 COG1106 ATPase/GTPase,_AAA15_family 86.0 0.3837209302325581 0.6162790697674418 0.757443364917004 0.917159297811599 0.8373013313643015 0.1597159328945949 1 1 1 1 K06927 0.8257142857142857 0.0142450142450142 DPH6; diphthine-ammonia ligase [EC:6.3.1.14] 154.0 252.0 191.0 3.0 0.794952681388013 S 311.0 5.0 3.0 0.867507886435331 COG2102 Diphthamide_synthase_(EF-2-diphthine--ammonia_ligase) Dph6 316.0 0.9841772151898734 0.0158227848101265 0.736749483306955 0.797980463642312 0.7673649734746335 0.061230980335357 0 1 0 1 K06928 0.3914285714285714 0.0683760683760683 NTPCR; nucleoside-triphosphatase [EC:3.6.1.15] path:map00230,path:map00730,path:map01100,path:map01110,path:map01232 Purine metabolism,Thiamine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 97.0 163.0 162.0 3.0 0.987878787878788 F 140.0 25.0 1.0 1.0 COG1618 Nucleoside-triphosphatase_THEP1 THEP1 165.0 0.8484848484848485 0.1515151515151515 0.868984457818986 0.964503051531739 0.9167437546753624 0.0955185937127529 1 1 1 1 K06929 0.4028571428571428 0.4387464387464387 K06929; uncharacterized protein 65.0 309.0 304.0 2.0 0.984076433121019 S 153.0 161.0 1.0 1.0 COG1832 Predicted_CoA-binding_protein YccU 314.0 0.4872611464968153 0.5127388535031847 0.0411366310739219 0.206777384058668 0.1239570075662949 0.1656407529847461 0 0 0 0 K06930 0.3571428571428571 0.0 bat; HTH-type transcriptional regulator, bacterioopsin transcriptional activator and related proteins 43.0 313.0 210.0 3.0 0.68942731277533 K 453.0 0.0 6.0 0.81057268722467 COG3413 Predicted_transcriptional_regulator,_contains_HTH_domain DmsR 453.0 1.0 0.0 0.0758020189661085 0.196885463025462 0.1363437409957852 0.1210834440593535 0 0 0 0 K06931 0.0171428571428571 0.0056980056980056 K06931; uncharacterized protein 158.0 7.0 6.0 2.0 0.875 S 6.0 3.0 3.0 0.666666666666667 COG4085 DNA/RNA_endonuclease_YhcR,_contains_UshA_esterase_domain YhcR 9.0 0.6666666666666666 0.3333333333333333 0.005703888726011 2.42928026973623e-05 0.0028640907643541 0.0056795959233136 0 0 0 0 K06932 0.6428571428571429 0.0 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22] 219.0 230.0 0.0 1.0 1.0 J 230.0 0.0 1.0 1.0 COG1571 tRNA(Ile2)_C34_agmatinyltransferase_TiaS TiaS 230.0 1.0 0.0 0.539674834157736 0.750033863926837 0.6448543490422864 0.210359029769101 0 0 0 1 K06933 0.2685714285714285 0.0313390313390313 K06933; uncharacterized protein 75.0 108.0 94.0 3.0 0.878048780487805 S 111.0 11.0 1.0 1.0 COG1342 Predicted_DNA-binding_protein,_UPF0251_family 122.0 0.9098360655737704 0.0901639344262295 0.997036396111262 0.869086511401155 0.9330614537562084 0.127949884710107 1 1 1 1 K06934 0.4342857142857143 0.1481481481481481 K06934; uncharacterized protein 69.0 212.0 193.0 2.0 0.917748917748918 S 175.0 56.0 1.0 1.0 COG1661 Predicted_DNA-binding_protein_with_PD1-like_DNA-binding_motif,_PPC/DUF296_domain AF0104 231.0 0.7575757575757576 0.2424242424242424 0.570925934311746 0.674246017501192 0.6225859759064689 0.1033200831894459 0 1 0 1 K06935 0.2542857142857143 0.0 K06935; uncharacterized protein 290.0 91.0 0.0 1.0 1.0 S 91.0 0.0 1.0 1.0 COG2100 Uncharacterized_Fe-S_cluster-containing_enzyme,_radical_SAM_superfamily 91.0 1.0 0.0 0.222294341582219 0.827416539360948 0.5248554404715835 0.6051221977787289 0 0 0 0 K06936 0.4914285714285714 0.017094017094017 raSEA; archaeosine synthase beta-subunit [EC:2.6.1.-] 178.0 168.0 149.0 2.0 0.898395721925134 S 181.0 6.0 1.0 1.0 COG1244 Archaeosine_formation_enzyme,_radical_SAM_superfamily RaSEA 187.0 0.9679144385026738 0.0320855614973262 0.740072036850647 0.915841914793019 0.827956975821833 0.1757698779423719 0 1 0 1 K06937 0.5342857142857143 0.0883190883190883 K06937; glycerol dibiphytanyl glycerol tetraether/macrocyclic archaeol synthase 267.0 188.0 145.0 5.0 0.731517509727626 S 224.0 33.0 3.0 0.964980544747082 COG1964 C-terminal_domain_of_the_GTP_3',8'-cyclase_MoaA,_radical_SAM_superfamily_(molybdenum_cofactor_biosynthesis) MoaA2 257.0 0.8715953307392996 0.1284046692607003 0.0653281667922433 0.104209467848967 0.0847688173206051 0.0388813010567236 0 0 0 0 K06938 0.0 0.1139601139601139 K06938; uncharacterized protein 46.0 48.0 0.0 1.0 1.0 S 0.0 48.0 1.0 1.0 COG3313 Predicted_Fe-S_protein_YdhL,_DUF1289_family YdhL 48.0 0.0 1.0 0.0056846637407863 0.0127518310277089 0.0092182473842476 0.0070671672869225 0 0 0 0 K06939 0.0742857142857142 0.0 K06939; uncharacterized protein 168.0 25.0 22.0 2.0 0.892857142857143 C 28.0 0.0 1.0 1.0 COG2000 Uncharacterized_Fe-S_cluster-containing_protein 28.0 1.0 0.0 0.23109612909968 0.0244985800949955 0.1277973545973377 0.2065975490046845 0 0 0 0 K06940 0.5485714285714286 0.3846153846153846 K06940; uncharacterized protein 8.0 570.0 567.0 3.0 0.993031358885017 S 363.0 211.0 5.0 0.987889273356401 COG0727 Uncharacterized_protein_YkgJ,_contains_CxxCxxCC_motif YkgJ 574.0 0.632404181184669 0.367595818815331 0.0136024046357899 0.0294236933605424 0.0215130489981661 0.0158212887247524 0 0 0 0 K06941 0.06 0.8490028490028491 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] 198.0 334.0 324.0 4.0 0.938202247191011 J 21.0 335.0 4.0 0.957865168539326 COG0820 Adenine_C2-methylase_RlmN_of_23S_rRNA_A2503_and_tRNA_A37 RlmN 356.0 0.0589887640449438 0.9410112359550562 0.0055727773514291 0.0018300749428754 0.0037014261471522 0.0037427024085537 0 0 0 0 K06942 0.9028571428571428 0.9772079772079773 ychF; ribosome-binding ATPase 176.0 733.0 732.0 2.0 0.998637602179836 J 378.0 356.0 2.0 0.998637602179836 COG0012 Ribosome-binding_ATPase_YchF,_GTP1/OBG_family GTP1 734.0 0.5149863760217984 0.4850136239782016 0.963471149868748 0.85806978918032 0.910770469524534 0.105401360688428 1 1 1 1 K06943 0.66 0.0 NOG1; nucleolar GTP-binding protein path:map03008 Ribosome biogenesis in eukaryotes 200.0 233.0 0.0 1.0 1.0 S 233.0 0.0 1.0 1.0 COG1084 GTP-binding_protein,_GTP1/Obg_family Nog1 233.0 1.0 0.0 0.0566334304735535 0.363218979956727 0.2099262052151402 0.3065855494831734 0 0 0 0 K06944 0.9142857142857144 0.0455840455840455 DRG, RBG; developmentally-regulated GTP-binding protein [EC:3.6.5.-] 225.0 299.0 248.0 2.0 0.854285714285714 S 334.0 16.0 1.0 1.0 COG1163 Ribosome-interacting_GTPase_RBG1 Rbg1 350.0 0.9542857142857144 0.0457142857142857 0.753403198967894 0.909002071821231 0.8312026353945625 0.155598872853337 1 1 1 1 K06945 0.1857142857142857 0.0854700854700854 K06945; uncharacterized protein 70.0 94.0 36.0 3.0 0.573170731707317 S 97.0 67.0 4.0 0.676829268292683 COG2229 Signal_recognition_particle_receptor_subunit_beta,_a_GTPase Srp102 164.0 0.5914634146341463 0.4085365853658536 0.875524705676985 0.982342523098121 0.9289336143875532 0.1068178174211359 1 1 1 1 K06946 0.0 0.0655270655270655 K06946; uncharacterized protein 118.0 32.0 31.0 2.0 0.96969696969697 S 0.0 33.0 4.0 0.878787878787879 COG3596 Predicted_GTPase YeeP 33.0 0.0 1.0 0.0029272809708772 0.0074381363465322 0.0051827086587047 0.004510855375655 0 0 0 0 K06947 0.2542857142857143 0.0256410256410256 GRC3, NOL9; polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 [EC:2.7.1.-] 138.0 98.0 83.0 2.0 0.867256637168142 A 104.0 9.0 2.0 0.867256637168142 COG5623 113.0 0.9203539823008848 0.079646017699115 0.933843683841311 0.0014272806707603 0.4676354822560356 0.9324164031705507 1 1 1 1 K06948 0.0 0.0854700854700854 yqeH; 30S ribosome assembly GTPase 318.0 31.0 0.0 1.0 1.0 S 0.0 31.0 1.0 1.0 COG1161 Ribosome_biogenesis_GTPase_RbgA RbgA 31.0 0.0 1.0 0.0011954908714065 0.0018184408120539 0.0015069658417302 0.0006229499406474 0 0 0 0 K06949 0.0428571428571428 0.6381766381766382 rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 95.0 275.0 269.0 4.0 0.958188153310104 S 15.0 271.0 1.0 1.0 COG1162 Ribosome_biogenesis_GTPase_RsgA RsgA 286.0 0.0524475524475524 0.9475524475524476 0.0112794398537363 0.36966247131119 0.1904709555824631 0.3583830314574537 0 0 0 0 K06950 0.5514285714285714 0.3817663817663818 K06950; uncharacterized protein 38.0 399.0 374.0 5.0 0.906818181818182 S 267.0 180.0 9.0 0.879194630872483 COG1418 HD_superfamily_phosphodieaserase,_includes_HD_domain_of_RNase_Y RnaY 447.0 0.5973154362416108 0.4026845637583892 0.53734529598717 0.579806937411479 0.5585761166993245 0.042461641424309 0 1 0 1 K06951 0.0914285714285714 0.1253561253561253 K06951; uncharacterized protein 153.0 63.0 49.0 2.0 0.818181818181818 S 32.0 45.0 1.0 1.0 COG2316 Predicted_hydrolase,_HD_superfamily 77.0 0.4155844155844156 0.5844155844155844 0.968720094278632 0.937348226763486 0.953034160521059 0.031371867515146 1 1 1 1 K06952 0.0257142857142857 0.0883190883190883 yfdR; 5'-nucleotidase [EC:3.1.3.89] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 119.0 44.0 0.0 1.0 1.0 S 9.0 35.0 1.0 1.0 COG1896 5'-deoxynucleotidase_YfbR_and_related_HD_superfamily_hydrolases YfbR 44.0 0.2045454545454545 0.7954545454545454 0.0043395598017606 0.0068831134985049 0.0056113366501327 0.0025435536967443 0 0 0 0 K06953 0.7628571428571429 0.0797720797720797 K06953; uncharacterized protein 81.0 371.0 0.0 1.0 1.0 S 343.0 28.0 1.0 1.0 COG1407 Metallophosphoesterase_superfamily_enzyme 371.0 0.9245283018867924 0.0754716981132075 0.503906086624381 0.0532811391921054 0.2785936129082432 0.4506249474322755 0 1 0 1 K06954 0.0 0.0968660968660968 K06954; uncharacterized protein 365.0 35.0 0.0 1.0 1.0 S 0.0 35.0 1.0 1.0 COG2907 Predicted_flavin-containing_amine_oxidase Ppro0129 35.0 0.0 1.0 0.0054495418804205 0.0212393536564473 0.0133444477684338 0.0157898117760268 0 0 0 0 K06955 0.1085714285714285 0.1253561253561253 181.0 83.0 81.0 2.0 0.976470588235294 S 39.0 46.0 2.0 0.941176470588235 COG3380 Predicted_NAD/FAD-dependent_oxidoreductase 85.0 0.4588235294117647 0.5411764705882353 0.0054146515938552 0.0718645751518363 0.0386396133728457 0.0664499235579811 0 0 0 0 K06956 0.0 0.0712250712250712 K06956; uncharacterized protein 236.0 29.0 27.0 3.0 0.90625 U 0.0 32.0 2.0 0.9375 COG1823 L-cystine_transporter_TcyP,_sodium:dicarboxylate_symporter_family TcyP 32.0 0.0 1.0 0.023638486507431 0.0526639266629612 0.0381512065851961 0.0290254401555302 0 0 0 0 K06957 0.3085714285714285 0.037037037037037 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193] 458.0 142.0 0.0 1.0 1.0 J 129.0 13.0 1.0 1.0 COG1444 tRNA(Met)_C34_N-acetyltransferase_TmcA TmcA 142.0 0.908450704225352 0.0915492957746478 0.380926141730157 0.846368401372948 0.6136472715515525 0.465442259642791 0 0 0 0 K06958 0.0 0.5270655270655271 rapZ; RNase adapter protein RapZ 213.0 175.0 161.0 2.0 0.925925925925926 S 0.0 189.0 2.0 0.994708994708995 COG1660 RNase_adaptor_protein_RapZ_for_GlmZ_sRNA_degradation,_contains_a_P-loop_ATPase_domain RapZ 189.0 0.0 1.0 0.05925317266684 0.0969690854887832 0.0781111290778116 0.0377159128219432 0 0 0 0 K06959 0.0342857142857142 0.50997150997151 tex; protein Tex 580.0 194.0 189.0 3.0 0.97 K 14.0 186.0 4.0 0.96 COG2183 Transcriptional_accessory_protein_Tex/SPT6 Tex 200.0 0.07 0.93 0.0112611388285431 0.905497340914742 0.4583792398716425 0.8942362020861989 0 0 0 0 K06960 0.0 0.6324786324786325 K06960; uncharacterized protein 59.0 199.0 164.0 4.0 0.836134453781513 S 0.0 238.0 1.0 1.0 COG1837 Predicted_RNA-binding_protein_YlqC,_contains_KH_domain,_UPF0109_family YlqC 238.0 0.0 1.0 0.0131702254702971 0.706073625055063 0.35962192526268 0.6929033995847659 0 0 0 0 K06961 0.9171428571428571 0.0 KRR1; ribosomal RNA assembly protein 116.0 323.0 0.0 1.0 1.0 J 323.0 0.0 1.0 1.0 COG1094 rRNA_processing_protein_Krr1/Pno1,_contains_KH_domain Krr1 323.0 1.0 0.0 0.013042134803706 0.0067810076703796 0.0099115712370428 0.0062611271333263 0 0 0 0 K06962 0.0 0.2564102564102564 K06962; uncharacterized protein 76.0 84.0 77.0 2.0 0.923076923076923 S 0.0 91.0 1.0 1.0 COG3688 EndoRNase_involved_in_mRNA_decay,_NYN_(Nedd4-BP1/Rae1/YacP_nuclease)_family,__contains_PIN_domain Rae1 91.0 0.0 1.0 0.0025855400705838 0.272910748330341 0.1377481442004624 0.2703252082597572 0 0 0 0 K06963 0.3285714285714285 0.0 TAN1, THUMPD1; tRNA acetyltransferase TAN1 60.0 136.0 110.0 2.0 0.839506172839506 S 160.0 0.0 2.0 0.987654320987654 COG1818 tRNA(Ser,Leu)_C12_N-acetylase_TAN1,_contains_THUMP_domain Tan1 160.0 1.0 0.0 0.0725870212489725 0.185865170681102 0.1292260959650372 0.1132781494321295 0 0 0 0 K06964 0.0571428571428571 0.0 K06964; uncharacterized protein 58.0 20.0 0.0 1.0 1.0 S 20.0 0.0 1.0 1.0 COG1532 Predicted_RNA-binding_protein 20.0 1.0 0.0 0.782102252965877 0.297519591478598 0.5398109222222375 0.4845826614872789 0 0 1 1 K06965 0.8485714285714285 0.0 PELO, DOM34, pelA; protein pelota path:map03015 mRNA surveillance pathway 217.0 304.0 0.0 1.0 1.0 J 304.0 0.0 1.0 1.0 COG1537 Stalled_ribosome_rescue_protein_Dom34,_pelota_family PelA 304.0 1.0 0.0 0.989663362935978 0.975921533442024 0.982792448189001 0.0137418294939539 0 0 1 1 K06966 0.4885714285714285 0.7977207977207977 ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 33.0 557.0 510.0 7.0 0.895498392282958 S 185.0 437.0 4.0 0.988745980707396 COG1611 Nucleotide_monophosphate_nucleosidase_PpnN/YdgH,_Lonely_Guy_(LOG)_family PpnN 622.0 0.297427652733119 0.702572347266881 0.0753632980608168 0.293620960815103 0.1844921294379599 0.2182576627542862 0 0 0 0 K06967 0.0 0.1623931623931624 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217] 136.0 49.0 41.0 3.0 0.844827586206896 S 0.0 58.0 2.0 0.948275862068966 COG2384 tRNA_A22_N1-methylase TrmK 58.0 0.0 1.0 0.0044731347003575 0.0190233499159207 0.0117482423081391 0.0145502152155631 0 0 0 0 K06968 0.0085714285714285 0.0769230769230769 rlmM; 23S rRNA (cytidine2498-2'-O)-methyltransferase [EC:2.1.1.186] 159.0 29.0 28.0 2.0 0.966666666666667 J 3.0 27.0 2.0 0.933333333333333 COG2933 23S_rRNA_C2498_(ribose-2'-O)-methylase_RlmM RlmM 30.0 0.1 0.9 0.265710814722193 0.942188842021018 0.6039498283716055 0.6764780272988251 0 0 0 0 K06969 0.0857142857142857 0.5555555555555556 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] 104.0 287.0 269.0 2.0 0.940983606557377 J 36.0 269.0 4.0 0.973770491803279 COG1092 23S_rRNA_G2069_N7-methylase_RlmK_or_C1962_C5-methylase_RlmI RlmK 305.0 0.1180327868852459 0.8819672131147541 0.70368709284128 0.121919792147633 0.4128034424944565 0.5817673006936469 0 1 0 1 K06970 0.0 0.0626780626780626 rlmF; 23S rRNA (adenine1618-N6)-methyltransferase [EC:2.1.1.181] 277.0 22.0 0.0 1.0 1.0 J 0.0 22.0 1.0 1.0 COG3129 23S_rRNA_A1618_N6-methylase_RlmF RlmF 22.0 0.0 1.0 0.0704492840728557 0.0855351765357165 0.077992230304286 0.0150858924628608 0 0 0 0 K06971 0.1942857142857142 0.1054131054131054 K06971; uncharacterized protein 209.0 113.0 0.0 1.0 1.0 S 71.0 42.0 1.0 1.0 COG0434 Membrane_biogenesis_protein,_BtpA/SgcQ_family BtpA 113.0 0.6283185840707964 0.3716814159292035 0.0436957709305793 0.881188752820501 0.4624422618755401 0.8374929818899217 0 0 0 0 K06972 0.0057142857142857 0.168091168091168 PITRM1, PreP, CYM1; presequence protease [EC:3.4.24.-] 145.0 56.0 22.0 3.0 0.615384615384615 S 2.0 89.0 5.0 0.615384615384615 COG1026 Zn-dependent_peptidase,_M16_(insulinase)_family Cym1 91.0 0.0219780219780219 0.978021978021978 0.0031826241402495 0.308067747395312 0.1556251857677807 0.3048851232550625 0 0 0 0 K06973 0.0 0.2962962962962963 K06973; uncharacterized protein 194.0 108.0 0.0 1.0 1.0 S 0.0 108.0 1.0 1.0 COG2738 Zn-dependent_membrane_protease_YugP YugP 108.0 0.0 1.0 0.917427229347211 0.0813272591252471 0.499377244236229 0.8360999702219639 0 0 1 1 K06974 0.3771428571428571 0.0826210826210826 amzA, AMZ2, AMZ1; archaemetzincin [EC:3.4.-.-] 81.0 159.0 130.0 2.0 0.845744680851064 S 150.0 38.0 1.0 1.0 COG1913 Predicted_Zn-dependent_protease 188.0 0.7978723404255319 0.202127659574468 0.94852124143973 0.800483964957652 0.874502603198691 0.1480372764820781 1 1 1 1 K06975 0.06 0.2364672364672364 K06975; uncharacterized protein 43.0 139.0 132.0 3.0 0.939189189189189 S 21.0 122.0 2.0 0.966216216216216 COG2388 Predicted_acetyltransferase,_GNAT_superfamily YidJ 143.0 0.1468531468531468 0.8531468531468531 0.020662182660395 0.302652236235957 0.161657209448176 0.281990053575562 0 0 0 0 K06976 0.02 0.131054131054131 K06976; uncharacterized protein 110.0 51.0 45.0 2.0 0.894736842105263 S 7.0 50.0 2.0 0.894736842105263 COG3393 Predicted_acetyltransferase,_GNAT_family 57.0 0.1228070175438596 0.8771929824561403 0.0055070105836636 0.0673030596522662 0.0364050351179649 0.0617960490686026 0 0 0 0 K06977 0.0142857142857142 0.0427350427350427 K06977; uncharacterized protein 122.0 11.0 2.0 2.0 0.55 S 5.0 15.0 2.0 0.55 COG3818 Predicted_N-acetyltransferase,_GNAT_superfamily 20.0 0.25 0.75 0.0124960027463282 0.037265575288866 0.0248807890175971 0.0247695725425378 0 0 0 0 K06978 0.0685714285714285 0.2478632478632478 K06978; uncharacterized protein 162.0 141.0 127.0 6.0 0.796610169491525 S 28.0 149.0 2.0 0.954802259887006 COG2936 Predicted_acyl_esterase 177.0 0.1581920903954802 0.8418079096045198 0.0191409241559695 0.600659978746537 0.3099004514512532 0.5815190545905675 0 0 0 0 K06979 0.0 0.0085470085470085 mph; macrolide phosphotransferase 295.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 4.0 0.0 1.0 3.4550503613417498e-12 7.112825750881199e-12 5.283938056111474e-12 3.657775389539449e-12 0 0 0 0 K06980 0.0228571428571428 0.3817663817663818 ygfZ; tRNA-modifying protein YgfZ 100.0 115.0 95.0 4.0 0.787671232876712 S 8.0 138.0 2.0 0.849315068493151 COG0354 Folate-binding_protein_YgfZ,_synthesis_and_repair_of_Fe-S_clusters YgfZ 146.0 0.0547945205479452 0.9452054794520548 0.0088368272120332 0.0095282065510191 0.0091825168815261 0.0006913793389858 0 0 0 0 K06981 0.7142857142857143 0.0284900284900284 ipk; isopentenyl phosphate kinase [EC:2.7.4.26] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 95.0 231.0 207.0 4.0 0.861940298507463 I 257.0 11.0 1.0 1.0 COG1608 Isopentenyl_phosphate_kinase 268.0 0.9589552238805972 0.0410447761194029 0.0886678595084786 0.480879592293365 0.2847737259009218 0.3922117327848864 0 0 0 0 K06982 0.6428571428571429 0.0056980056980056 pok; pantoate kinase [EC:2.7.1.169] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 106.0 233.0 0.0 1.0 1.0 S 231.0 2.0 1.0 1.0 COG1829 Archaeal_pantoate_kinase 233.0 0.9914163090128756 0.0085836909871244 0.177707847204894 0.323057819893159 0.2503828335490265 0.145349972688265 0 0 0 0 K06983 0.1571428571428571 0.0113960113960113 K06983; uncharacterized protein 181.0 32.0 3.0 2.0 0.524590163934426 S 57.0 4.0 1.0 1.0 COG2521 Predicted_archaeal_methyltransferase 61.0 0.9344262295081968 0.0655737704918032 0.9154715620473 0.98041657006099 0.9479440660541448 0.06494500801369 1 1 1 1 K06984 0.3942857142857143 0.0085470085470085 K06984; beta-ribofuranosylaminobenzene 5'-phosphate synthase [EC:2.4.2.54] path:map00790 Folate biosynthesis 197.0 70.0 11.0 3.0 0.419161676646707 H 164.0 3.0 3.0 0.946107784431138 COG1907 Beta-ribofuranosylaminobenzene_5'-phosphate_synthase_(methanopterin_biosynthesis) bRFAP 167.0 0.9820359281437124 0.0179640718562874 0.390093880253272 0.106820693538524 0.248457286895898 0.283273186714748 0 0 0 0 K06985 0.0114285714285714 0.1196581196581196 K06985; aspartyl protease family protein path:map04112 Cell cycle - Caulobacter 68.0 60.0 57.0 2.0 0.952380952380952 S 6.0 57.0 3.0 0.920634920634921 COG3577 Predicted_aspartyl_protease 63.0 0.0952380952380952 0.9047619047619048 0.0185887945152221 0.0144360594668235 0.0165124269910228 0.0041527350483986 0 0 0 0 K06986 0.04 0.0341880341880341 K06986; uncharacterized protein 105.0 23.0 18.0 2.0 0.821428571428571 S 16.0 12.0 1.0 1.0 COG3233 Predicted_deacetylase 28.0 0.5714285714285714 0.4285714285714285 0.418260880278026 0.939090132293986 0.6786755062860059 0.52082925201596 0 0 0 0 K06987 0.2371428571428571 0.2051282051282051 K06987; uncharacterized protein 102.0 215.0 206.0 6.0 0.881147540983607 S 140.0 104.0 5.0 0.938524590163934 COG3608 Predicted_deacylase 244.0 0.5737704918032787 0.4262295081967213 0.0531317873702056 0.830644825088126 0.4418883062291658 0.7775130377179204 0 0 0 0 K06988 0.4028571428571428 0.1794871794871795 fno; 8-hydroxy-5-deazaflavin:NADPH oxidoreductase [EC:1.5.1.40] 72.0 273.0 230.0 2.0 0.863924050632911 S 199.0 117.0 3.0 0.854430379746835 COG2085 Predicted_dinucleotide-binding_enzyme 316.0 0.629746835443038 0.370253164556962 0.268574850228336 0.361422450360344 0.31499865029434 0.0928476001320079 0 0 0 0 K06989 0.2885714285714286 0.0797720797720797 nadX, ASPDH; aspartate dehydrogenase [EC:1.4.1.21] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 179.0 64.0 6.0 4.0 0.481203007518797 F 105.0 28.0 1.0 1.0 COG1712 L-aspartate_dehydrogenase,_NAD(P)-dependent AspD 133.0 0.7894736842105263 0.2105263157894736 0.965654985982751 0.922003817476294 0.9438294017295226 0.043651168506457 1 1 1 1 K06990 0.6542857142857142 0.3874643874643874 MEMO1; MEMO1 family protein 58.0 409.0 383.0 4.0 0.912946428571429 S 241.0 185.0 4.0 0.859375 COG1355 Predicted_class_III_extradiol_dioxygenase,_MEMO1_family Mho1 426.0 0.5657276995305164 0.4342723004694835 0.239386337481483 0.787865550804246 0.5136259441428646 0.5484792133227631 0 0 0 0 K06991 0.02 0.1424501424501424 K06991; uncharacterized protein 114.0 70.0 69.0 2.0 0.985915492957746 S 9.0 62.0 1.0 1.0 COG3565 Predicted_dioxygenase_of_extradiol_dioxygenase_family 71.0 0.1267605633802817 0.8732394366197183 0.0048835057188121 0.0147231992047688 0.0098033524617904 0.0098396934859567 0 0 0 0 K06992 0.0142857142857142 0.0455840455840455 K06992; uncharacterized protein 124.0 18.0 0.0 1.0 1.0 S 6.0 16.0 1.0 1.0 COG3271 Predicted_double-glycine_leader_peptidase,_C39-like_(CLD)_domain C39G 22.0 0.2727272727272727 0.7272727272727273 0.0295446554039037 0.0650656500577113 0.0473051527308075 0.0355209946538075 0 0 0 0 K06993 0.0085714285714285 0.0598290598290598 K06993; ribonuclease H-related protein 102.0 24.0 0.0 1.0 1.0 L 3.0 21.0 2.0 0.75 COG0328 Ribonuclease_HI RnhA 24.0 0.125 0.875 0.0735524059300625 0.635452809529 0.3545026077295312 0.5619004035989374 0 0 0 0 K06994 0.1885714285714285 0.1937321937321937 K06994; putative drug exporter of the RND superfamily 241.0 179.0 137.0 11.0 0.606779661016949 S 93.0 202.0 12.0 0.854237288135593 COG2409 Predicted_lipid_transporter_YdfJ,_MMPL/SSD_domain,_RND_superfamily YdfJ 295.0 0.3152542372881356 0.6847457627118644 0.969013520958747 0.930518927012256 0.9497662239855016 0.038494593946491 1 1 1 1 K06995 0.0257142857142857 0.1253561253561253 K06995; uncharacterized protein 48.0 63.0 58.0 2.0 0.926470588235294 S 9.0 59.0 1.0 1.0 COG3450 Predicted_enzyme_of_the_cupin_superfamily 68.0 0.1323529411764706 0.8676470588235294 0.0288155187025649 0.114936653975786 0.0718760863391754 0.0861211352732211 0 0 0 0 K06996 0.1257142857142857 0.2849002849002849 K06996; uncharacterized protein 44.0 167.0 108.0 4.0 0.726086956521739 S 64.0 167.0 3.0 0.974025974025974 COG3324 Lactoylglutathione_lyase-related_enzyme,_vicinal_oxygen_chelate_(VOC)_family VOC 231.0 0.277056277056277 0.7229437229437229 0.113833026167954 0.405745563363298 0.259789294765626 0.291912537195344 0 0 0 0 K06997 0.0914285714285714 0.8461538461538461 yggS, PROSC; PLP dependent protein 97.0 328.0 321.0 4.0 0.950724637681159 S 32.0 313.0 2.0 0.988405797101449 COG0325 Pyridoxal_5'-phosphate_homeostasis_protein_YggS,_UPF0001_family YggS 345.0 0.0927536231884058 0.9072463768115944 0.0155361098660209 0.221067427762163 0.1183017688140919 0.2055313178961421 0 0 0 0 K06998 0.0942857142857142 0.1452991452991453 phzF; trans-2,3-dihydro-3-hydroxyanthranilate isomerase [EC:5.3.3.17] path:map00405,path:map01100,path:map01110,path:map02024 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 163.0 98.0 0.0 1.0 1.0 S 40.0 58.0 1.0 1.0 COG0384 Predicted_epimerase_YddE/YHI9,_PhzF_superfamily YHI9 98.0 0.4081632653061224 0.5918367346938775 0.418636719499866 0.899579127446323 0.6591079234730944 0.480942407946457 0 0 0 0 K06999 0.1485714285714285 0.3903133903133903 K06999; phospholipase/carboxylesterase 57.0 240.0 233.0 3.0 0.96 S 72.0 179.0 4.0 0.745019920318725 COG0400 Predicted_esterase YpfH 251.0 0.2868525896414343 0.7131474103585658 0.0026915893463186 0.001537327379877 0.0021144583630978 0.0011542619664415 0 0 0 0 K07000 0.04 0.1481481481481481 K07000; uncharacterized protein 50.0 79.0 77.0 3.0 0.963414634146341 S 23.0 60.0 4.0 0.590361445783133 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 83.0 0.2771084337349397 0.7228915662650602 0.0090810501191611 0.0279844467437239 0.0185327484314425 0.0189033966245628 0 0 0 0 K07001 0.0942857142857142 0.6296296296296297 K07001; NTE family protein 5.0 364.0 257.0 10.0 0.7109375 S 53.0 439.0 9.0 0.91796875 COG1752 Predicted_acylesterase/phospholipase_RssA,_containd_patatin_domain RssA 492.0 0.1077235772357723 0.8922764227642277 0.663298447765458 0.35242986894038 0.507864158352919 0.310868578825078 0 1 0 1 K07002 0.0742857142857142 0.1538461538461538 RBBP9; serine hydrolase [EC:3.-.-.-] 56.0 103.0 102.0 2.0 0.990384615384615 S 31.0 73.0 5.0 0.778846153846154 COG3545 Predicted_esterase_of_the_alpha/beta_hydrolase_fold YdeN 104.0 0.2980769230769231 0.7019230769230769 0.0030050828620714 0.287349276952225 0.1451771799071482 0.2843441940901536 0 0 0 0 K07003 0.2657142857142857 0.4045584045584046 K07003; uncharacterized protein 124.0 325.0 308.0 12.0 0.804455445544554 S 160.0 244.0 13.0 0.816831683168317 COG1033 Predicted_exporter_protein,_RND_superfamily MMPL 404.0 0.396039603960396 0.6039603960396039 0.883668437540601 0.720962139437768 0.8023152884891844 0.162706298102833 1 1 1 1 K07004 0.0485714285714285 0.2849002849002849 K07004; uncharacterized protein 5.0 36.0 8.0 20.0 0.184615384615385 S 18.0 156.0 42.0 0.346341463414634 COG2374 Predicted_extracellular_nuclease 174.0 0.1034482758620689 0.896551724137931 0.0255513164786657 0.305971957171899 0.1657616368252823 0.2804206406932333 0 0 0 0 K07005 0.3314285714285714 0.3447293447293447 K07005; uncharacterized protein 16.0 347.0 293.0 10.0 0.828162291169451 S 254.0 172.0 11.0 0.828638497652582 COG3467 Nitroimidazole_reductase_NimA_or_a_related_FMN-containing_flavoprotein,_pyridoxamine_5'-phosphate_oxidase_superfamily NimA 426.0 0.596244131455399 0.4037558685446009 0.005043419517663 0.0471315630834247 0.0260874913005438 0.0420881435657616 0 0 0 0 K07006 0.22 0.2706552706552707 K07006; uncharacterized protein 24.0 233.0 212.0 5.0 0.87593984962406 S 121.0 146.0 9.0 0.831460674157303 COG3576 Predicted_flavin-nucleotide-binding_protein,_pyridoxine_5'-phosphate_oxidase_superfamily 267.0 0.4531835205992509 0.5468164794007491 0.0113841846736782 0.0283905326746591 0.0198873586741686 0.0170063480009809 0 0 0 0 K07007 0.0428571428571428 0.5441595441595442 baiN; 3-dehydro-bile acid Delta4,6-reductase [EC:1.3.1.114] path:map00121 Secondary bile acid biosynthesis 169.0 251.0 245.0 3.0 0.972868217054264 S 15.0 243.0 1.0 1.0 COG2081 Predicted_flavoprotein_YhiN YhiN 258.0 0.0581395348837209 0.9418604651162792 0.0022251675384991 0.0356608130400618 0.0189429902892804 0.0334356455015627 0 0 0 0 K07008 0.0057142857142857 0.0398860398860398 egtC; gamma-glutamyl hercynylcysteine S-oxide hydrolase [EC:3.5.1.118] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 193.0 19.0 0.0 1.0 1.0 S 2.0 17.0 1.0 1.0 COG0121 Predicted_glutamine_amidotransferase_YafJ YafJ 19.0 0.1052631578947368 0.8947368421052632 0.0118972501883434 0.0498835679205542 0.0308904090544488 0.0379863177322108 0 0 0 0 K07009 0.0314285714285714 0.1595441595441595 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 162.0 47.0 27.0 2.0 0.701492537313433 S 11.0 56.0 2.0 0.835820895522388 COG3442 Glutamine_amidotransferase_related_to_the_GATase_domain_of_CobQ 67.0 0.1641791044776119 0.835820895522388 0.16338687847352 0.943056639793927 0.5532217591337235 0.779669761320407 0 0 0 0 K07010 0.0542857142857142 0.4245014245014245 K07010; putative glutamine amidotransferase 90.0 210.0 207.0 5.0 0.963302752293578 S 23.0 195.0 2.0 0.995412844036697 COG2071 Gamma-glutamyl-gamma-aminobutyrate_hydrolase_PuuD_(putrescine_degradation),_contains_GATase1-like_domain PuuD 218.0 0.1055045871559633 0.8944954128440367 0.0089822006006673 0.358376674399307 0.1836794374999871 0.3493944737986397 0 0 0 0 K07011 0.2685714285714285 0.5470085470085471 5.0 304.0 173.0 11.0 0.520547945205479 M 135.0 428.0 15.0 0.746575342465753 COG1216 Glycosyltransferase,_GT2_family WcaE 563.0 0.2397868561278863 0.7602131438721137 0.202038026574124 0.515814555517952 0.358926291046038 0.3137765289438279 0 0 0 0 K07012 0.3628571428571429 0.4245014245014245 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4] 41.0 304.0 206.0 6.0 0.689342403628118 L 204.0 228.0 12.0 0.832199546485261 COG1203 CRISPR-Cas_type_I_system-associated_endonuclease/helicase_Cas3 Cas3 432.0 0.4722222222222222 0.5277777777777778 0.799802610489182 0.820071085921116 0.809936848205149 0.0202684754319339 1 1 1 1 K07013 0.0 0.0 K07013; uncharacterized protein 145.0 91.0 4.0 0.627705627705628 K 0.0 0.0 7.0 0.805194805194805 COG1719 Predicted_hydrocarbon_binding_protein,_contains_4VR_domain 0.0 0 0 0 0 K07014 0.0 0.0569800569800569 K07014; uncharacterized protein 365.0 19.0 18.0 3.0 0.904761904761905 S 0.0 21.0 3.0 0.904761904761905 COG3083 Periplasmic_protein_PbgA/YejM,_regulator_of_the_LPS_biosynthesis,_AlkP_superfamily YejM 21.0 0.0 1.0 0.0074873413886078 0.0101795550675474 0.0088334482280776 0.0026922136789395 0 0 0 0 K07015 0.0028571428571428 0.2022792022792023 yqeG; putative phosphatase [EC:3.1.3.-] 86.0 68.0 63.0 2.0 0.931506849315068 S 1.0 72.0 2.0 0.972602739726027 COG2179 Predicted_phosphohydrolase_YqeG,_HAD_superfamily YqeG 73.0 0.0136986301369863 0.9863013698630136 0.237719158485364 0.0777797149836595 0.1577494367345117 0.1599394435017045 0 0 0 0 K07016 0.0628571428571428 0.1196581196581196 csm1, cas10; CRISPR-associated protein Csm1 88.0 29.0 1.0 4.0 0.341176470588235 J 26.0 58.0 4.0 0.905882352941176 COG1353 CRISPR/Cas_system-associated_protein_Cas10,_large_subunit_of_type_III_CRISPR-Cas_systems,_contains_HD_superfamily_nuclease_domain Cas10 84.0 0.3095238095238095 0.6904761904761905 0.963838251792853 0.966762565804589 0.9653004087987208 0.0029243140117359 1 1 1 1 K07017 0.0142857142857142 0.1196581196581196 K07017; uncharacterized protein 78.0 51.0 35.0 5.0 0.6375 S 6.0 74.0 6.0 0.6625 COG2819 Predicted_hydrolase_of_the_alpha/beta_superfamily YbbA 80.0 0.075 0.925 0.0026154077458523 0.0166567378687149 0.0096360728072836 0.0140413301228626 0 0 0 0 K07018 0.1685714285714285 0.2108262108262108 K07018; uncharacterized protein 81.0 127.0 126.0 2.0 0.9921875 S 59.0 76.0 3.0 0.977777777777778 COG2945 Alpha/beta_superfamily_hydrolase 135.0 0.437037037037037 0.562962962962963 0.0076567005152709 0.0564041667999567 0.0320304336576138 0.0487474662846858 0 0 0 0 K07019 0.0028571428571428 0.2051282051282051 K07019; uncharacterized protein 170.0 80.0 0.0 1.0 1.0 S 1.0 79.0 2.0 0.975 COG0429 Predicted_hydrolase_of_the_alpha/beta-hydrolase_fold YheT 80.0 0.0125 0.9875 0.0062150372977557 0.0504180859030693 0.0283165616004125 0.0442030486053136 0 0 0 0 K07020 0.0285714285714285 0.1396011396011396 K07020; uncharacterized protein 95.0 53.0 0.0 1.0 1.0 S 11.0 51.0 3.0 0.838709677419355 COG3571 Predicted_hydrolase_of_the_alpha/beta-hydrolase_fold 62.0 0.1774193548387097 0.8225806451612904 0.114313684478247 0.785382213942948 0.4498479492105975 0.6710685294647011 0 0 0 0 K07022 0.3342857142857143 0.0455840455840455 K07022; uncharacterized protein 171.0 149.0 0.0 1.0 1.0 S 139.0 19.0 1.0 1.0 COG2248 Predicted_hydrolase,_metallo-beta-lactamase_superfamily 158.0 0.879746835443038 0.120253164556962 0.670660333200137 0.834820389189655 0.752740361194896 0.164160055989518 0 1 0 1 K07023 0.4371428571428571 0.2877492877492877 YGK1, HDDC2; 5'-deoxynucleotidase [EC:3.1.3.89] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 50.0 279.0 271.0 7.0 0.926910299003322 S 166.0 134.0 4.0 0.976744186046512 COG1896 5'-deoxynucleotidase_YfbR_and_related_HD_superfamily_hydrolases YfbR 300.0 0.5533333333333333 0.4466666666666666 0.0418220187610036 0.680209769812566 0.3610158942867847 0.6383877510515624 0 0 0 0 K07024 0.0028571428571428 0.037037037037037 SPP; sucrose-6-phosphatase [EC:3.1.3.24] path:map00500,path:map01110 Starch and sucrose metabolism,Biosynthesis of secondary metabolites 207.0 11.0 8.0 4.0 0.578947368421053 S 1.0 17.0 2.0 0.947368421052632 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 18.0 0.0555555555555555 0.9444444444444444 0.0034414311604789 0.0146649293573611 0.00905318025892 0.0112234981968822 0 0 0 0 K07025 0.0 0.0 K07025; putative hydrolase of the HAD superfamily 1051.0 1026.0 9.0 0.960694698354662 S 0.0 0.0 11.0 0.869287020109689 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 0.0 0 0 0 0 K07026 0.08 0.0826210826210826 E3.1.3.70; mannosyl-3-phosphoglycerate phosphatase [EC:3.1.3.70] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 180.0 57.0 0.0 1.0 1.0 S 28.0 29.0 1.0 1.0 COG3769 Mannosyl-3-phosphoglycerate_phosphatase_YedP/MpgP,_HAD_superfamily YedP 57.0 0.4912280701754385 0.5087719298245614 0.38292207747094 0.245342902827606 0.314132490149273 0.1375791746433339 0 0 0 0 K07027 0.6485714285714286 0.5299145299145299 K07027; glycosyltransferase 2 family protein 5.0 563.0 383.0 7.0 0.708176100628931 S 415.0 333.0 3.0 0.979874213836478 COG0392 Predicted_membrane_flippase_AglD2/YbhN,_UPF0104_family AglD2 748.0 0.5548128342245989 0.4451871657754011 0.136218779319235 0.477874698018337 0.307046738668786 0.3416559186991019 0 0 0 0 K07028 0.0942857142857142 0.225071225071225 K07028; uncharacterized protein 81.0 99.0 80.0 3.0 0.779527559055118 S 34.0 83.0 4.0 0.68503937007874 COG0645 Predicted_kinase,_contains_AAA_domain 117.0 0.2905982905982906 0.7094017094017094 0.0064041766311266 0.0279565038006022 0.0171803402158643 0.0215523271694756 0 0 0 0 K07029 0.0085714285714285 0.1566951566951566 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] path:map00561,path:map00564,path:map01100,path:map01110 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 166.0 59.0 58.0 2.0 0.983333333333333 I 3.0 57.0 1.0 1.0 COG1597 Phosphatidylglycerol_kinase,_diacylglycerol_kinase_family LCB5 60.0 0.05 0.95 0.0039440597984761 0.37296001806429 0.188452038931383 0.3690159582658139 0 0 0 0 K07030 0.0114285714285714 0.301994301994302 fakA; fatty acid kinase [EC:2.7.2.18] 314.0 122.0 0.0 1.0 1.0 S 5.0 117.0 2.0 0.950819672131148 COG1461 Predicted_kinase_related_to_dihydroxyacetone_kinase YloV 122.0 0.040983606557377 0.9590163934426228 0.761086139494649 0.556102250449108 0.6585941949718785 0.204983889045541 1 1 1 1 K07031 0.1628571428571428 0.1652421652421652 hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 137.0 116.0 86.0 4.0 0.748387096774194 S 82.0 73.0 4.0 0.967741935483871 COG2605 Predicted_kinase_related_to_galactokinase_and_mevalonate_kinase 155.0 0.5290322580645161 0.4709677419354838 0.0081543244297579 0.117645301593557 0.0628998130116574 0.1094909771637991 0 0 0 0 K07032 0.0685714285714285 0.1823361823361823 K07032; uncharacterized protein 75.0 79.0 49.0 3.0 0.718181818181818 E 27.0 86.0 3.0 0.610619469026549 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 113.0 0.2389380530973451 0.7610619469026548 0.0342120511470991 0.0938667798642654 0.0640394155056822 0.0596547287171663 0 0 0 0 K07033 0.4342857142857143 0.2991452991452991 K07033; uncharacterized protein 135.0 321.0 0.0 1.0 1.0 O 175.0 146.0 1.0 1.0 COG0719 Fe-S_cluster_assembly_scaffold_protein_SufB SufB 321.0 0.5451713395638629 0.454828660436137 0.0421727636550546 0.40845534606418 0.2253140548596173 0.3662825824091253 0 0 0 0 K07034 0.1742857142857143 0.1225071225071225 K07034; uncharacterized protein 135.0 132.0 0.0 1.0 1.0 S 85.0 50.0 4.0 0.97037037037037 COG1584 Succinate-acetate_transporter_SatP SatP 135.0 0.6296296296296297 0.3703703703703703 0.0769641889249289 0.0690960370923072 0.073030113008618 0.0078681518326216 0 0 0 0 K07035 0.0 0.0883190883190883 K07035; uncharacterized protein 304.0 36.0 0.0 1.0 1.0 S 0.0 36.0 1.0 1.0 COG3641 Membrane_regulatory_protein_PfoR,_PTS_EIIC_2_domain_(does_not_regulate_perfringolysin_expression) PfoR 36.0 0.0 1.0 0.0051471685354674 0.014178717178065 0.0096629428567662 0.0090315486425976 0 0 0 0 K07037 0.0 0.396011396011396 pgpH; cyclic-di-AMP phosphodiesterase PgpH [EC:3.1.4.-] 327.0 125.0 110.0 2.0 0.892857142857143 S 0.0 140.0 2.0 0.992857142857143 COG1480 Cyclic_di-AMP-specific_phosphodiesterase_PgpH,_HD_superfamily PgpH 140.0 0.0 1.0 0.729963702677679 0.34813717194039 0.5390504373090345 0.3818265307372889 0 0 0 1 K07038 0.4371428571428571 0.2421652421652421 K07038; inner membrane protein 12.0 290.0 266.0 5.0 0.889570552147239 S 211.0 112.0 10.0 0.513761467889908 COG1988 Membrane-bound_metal-dependent_hydrolase_YbcI,_DUF457_family YbcI 323.0 0.653250773993808 0.3467492260061919 0.114372448494376 0.032179493483935 0.0732759709891555 0.082192955010441 0 0 0 0 K07039 0.0085714285714285 0.1025641025641025 K07039; uncharacterized protein 43.0 22.0 10.0 5.0 0.523809523809524 S 3.0 46.0 5.0 0.392156862745098 COG3012 Uncharacterized_conserved_protein_YchJ,_contains_N-_and_C-terminal_SEC-C_domains YchJ 49.0 0.0612244897959183 0.9387755102040816 0.0641572540642705 0.0160381013862675 0.040097677725269 0.048119152678003 0 0 0 0 K07040 0.0 0.6524216524216524 yceD, ylbN; DUF177 domain-containing protein 18.0 203.0 170.0 2.0 0.860169491525424 S 0.0 236.0 2.0 0.970338983050847 COG1399 23S_rRNA_accumulation_protein_YceD_(essential_in_plants,_uncharacterized_in_bacteria) YceD 236.0 0.0 1.0 0.117296247202348 0.235151825968485 0.1762240365854165 0.1178555787661369 0 0 0 0 K07041 0.9428571428571428 0.0056980056980056 K07041; uncharacterized protein 477.0 371.0 355.0 2.0 0.958656330749354 S 385.0 2.0 2.0 0.958656330749354 COG1782 Predicted_metal-dependent_RNase,_contains_metallo-beta-lactamase_and_KH_domains 387.0 0.9948320413436692 0.0051679586563307 0.953714117324469 0.967680743523334 0.9606974304239017 0.013966626198865 0 0 1 1 K07042 0.0 0.8490028490028491 ybeY, yqfG; probable rRNA maturation factor 49.0 172.0 67.0 5.0 0.56953642384106 J 0.0 302.0 3.0 0.993377483443709 COG0319 ssRNA-specific_RNase_YbeY,_16S_rRNA_maturation_enzyme YbeY 302.0 0.0 1.0 0.816466542101614 0.776537602079364 0.796502072090489 0.03992894002225 0 0 1 1 K07043 0.3 0.5441595441595442 upp; UTP pyrophosphatase [EC:3.6.1.-] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 23.0 343.0 336.0 3.0 0.963483146067416 S 127.0 235.0 2.0 0.978021978021978 COG1451 UTP_pyrophosphatase,_metal-dependent_hydrolase_family YgjP 362.0 0.3508287292817679 0.649171270718232 0.0315949095797758 0.320404758583176 0.1759998340814759 0.2888098490034002 0 0 0 0 K07044 0.0 0.037037037037037 K07044; uncharacterized protein 183.0 28.0 0.0 1.0 1.0 S 0.0 28.0 1.0 1.0 COG3687 Predicted_metal-dependent_hydrolase 28.0 0.0 1.0 0.003253827460419 0.0075270327830425 0.0053904301217307 0.0042732053226234 0 0 0 0 K07045 0.0 0.0 K07045; uncharacterized protein 432.0 377.0 6.0 0.864 S 0.0 0.0 5.0 0.98 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 0.0 0 0 0 0 K07046 0.0142857142857142 0.1396011396011396 K07046; L-fuconolactonase [EC:3.1.1.-] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 208.0 53.0 47.0 3.0 0.841269841269841 S 5.0 58.0 2.0 0.920634920634921 COG3618 Predicted_metal-dependent_hydrolase,_TIM-barrel_fold 63.0 0.0793650793650793 0.9206349206349206 0.0302839859357319 0.222400654114887 0.1263423200253094 0.1921166681791551 0 0 0 0 K07048 0.0171428571428571 0.0997150997150997 PTER, php; phosphotriesterase-related protein 218.0 55.0 51.0 2.0 0.932203389830508 S 7.0 52.0 1.0 1.0 COG1735 Predicted_metal-dependent_hydrolase,_phosphotriesterase_family Php 59.0 0.1186440677966101 0.8813559322033898 0.487520513709722 0.723781747379256 0.605651130544489 0.236261233669534 0 0 0 0 K07049 0.42 0.0 K07049; TatD-related deoxyribonuclease 210.0 148.0 0.0 1.0 1.0 S 148.0 0.0 1.0 1.0 COG1831 Predicted_metal-dependent_hydrolase,_urease_superfamily 148.0 1.0 0.0 0.426909727948536 0.0061818085215743 0.2165457682350551 0.4207279194269617 0 0 0 0 K07050 0.4828571428571429 0.0883190883190883 AARSD1, ALAX; misacylated tRNA(Ala) deacylase [EC:3.1.1.-] 137.0 180.0 142.0 3.0 0.821917808219178 J 187.0 32.0 2.0 0.821917808219178 COG0013 Alanyl-tRNA_synthetase AlaS 219.0 0.8538812785388128 0.1461187214611872 0.96926816540982 0.810826550467702 0.890047357938761 0.1584416149421179 1 1 1 1 K07051 0.1342857142857142 0.0826210826210826 K07051; uncharacterized protein 202.0 84.0 0.0 1.0 1.0 S 55.0 29.0 1.0 1.0 COG1099 Predicted_metal-dependent_hydrolase,_TIM-barrel_fold 84.0 0.6547619047619048 0.3452380952380952 0.330015004012793 0.341288408286876 0.3356517061498345 0.011273404274083 0 0 0 0 K07052 0.0 0.0 K07052; CAAX protease family protein 734.0 625.0 10.0 0.839816933638444 S 0.0 0.0 17.0 0.941714285714286 COG1266 Membrane_protease_YdiL,_CAAX_protease_family YdiL 0.0 0 0 0 0 K07053 0.0857142857142857 0.5527065527065527 E3.1.3.97; 3',5'-nucleoside bisphosphate phosphatase [EC:3.1.3.97] 38.0 248.0 215.0 8.0 0.797427652733119 S 35.0 278.0 7.0 0.913738019169329 COG0613 5'-3'_exoribonuclease_TrpH/YciV_(RNase_AM),_contains_PHP_domain YciV 313.0 0.1118210862619808 0.8881789137380192 0.692403155160301 0.642087217334904 0.6672451862476025 0.050315937825397 0 1 0 1 K07054 0.0057142857142857 0.2051282051282051 K07054; uncharacterized protein 123.0 106.0 105.0 2.0 0.990654205607477 S 2.0 105.0 2.0 0.990654205607477 COG2321 Predicted_metalloprotease YpfJ 107.0 0.0186915887850467 0.9813084112149532 0.0010368600223611 0.0051411990020179 0.0030890295121895 0.0041043389796567 0 0 0 0 K07055 0.4857142857142857 0.0 TRM12, TYW2; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114] 162.0 172.0 171.0 2.0 0.994219653179191 J 173.0 0.0 2.0 0.942196531791908 COG2520 tRNA_G37_N-methylase_Trm5 Trm5 173.0 1.0 0.0 0.899837697529139 0.318033144684408 0.6089354211067735 0.581804552844731 0 0 1 1 K07056 0.0028571428571428 0.9031339031339032 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] 152.0 360.0 355.0 2.0 0.986301369863014 H 1.0 364.0 1.0 1.0 COG0313 16S_rRNA_C1402_(ribose-2'-O)_methylase_RsmI RsmI 365.0 0.0027397260273972 0.9972602739726028 0.0028696649394536 0.0183936924789768 0.0106316787092151 0.0155240275395232 0 0 0 0 K07057 0.1028571428571428 0.0683760683760683 bpsA; N4-bis(aminopropyl)spermidine synthase [EC:2.5.1.128] 227.0 46.0 28.0 3.0 0.666666666666667 H 42.0 24.0 3.0 0.942028985507247 COG1568 Aminopropyltransferase_BpsA,_N(4)-bis(aminopropyl)spermidine_biosynthesis BpsA 66.0 0.6363636363636364 0.3636363636363636 0.975642829908152 0.907095568709755 0.9413691993089536 0.0685472611983969 1 1 1 1 K07058 0.1457142857142857 0.6809116809116809 K07058; membrane protein 33.0 322.0 244.0 8.0 0.689507494646681 S 99.0 367.0 10.0 0.950749464668094 COG1295 Uncharacterized_membrane_protein,_BrkB/YihY/UPF0761_family_(not_an_RNase) BrkB 466.0 0.2124463519313304 0.7875536480686696 0.0005132212294678 0.0179314758485136 0.0092223485389907 0.0174182546190458 0 0 0 0 K07059 0.4742857142857143 0.0655270655270655 K07059; uncharacterized protein 97.0 146.0 100.0 4.0 0.682242990654206 E 191.0 23.0 3.0 0.901869158878505 COG0705 Membrane-associated_serine_protease,_rhomboid_family GlpG 214.0 0.8925233644859814 0.1074766355140186 0.675947906564341 0.534399998836463 0.6051739527004021 0.1415479077278779 0 1 0 1 K07060 0.6828571428571428 0.0 nob1; endoribonuclease Nob1 [EC:3.1.-.-] 65.0 230.0 217.0 2.0 0.946502057613169 V 243.0 0.0 1.0 1.0 COG1439 rRNA_maturation_endonuclease_Nob1 Nob1 243.0 1.0 0.0 0.0128167763488544 0.381668833308117 0.1972428048284857 0.3688520569592626 0 0 0 0 K07061 0.1228571428571428 0.1452991452991453 cmr1; CRISPR-associated protein Cmr1 21.0 68.0 44.0 4.0 0.591304347826087 L 51.0 63.0 5.0 0.626086956521739 COG1367 CRISPR-Cas_system_type_III_CMR-effector_complex_subunit_Cmr1,_RAMP_superfamily_Cas7_group Cmr1 114.0 0.4473684210526316 0.5526315789473685 0.896608110629887 0.839422098499101 0.8680151045644939 0.057186012130786 1 1 1 1 K07062 0.0 0.1481481481481481 fitB; toxin FitB [EC:3.1.-.-] 82.0 79.0 77.0 2.0 0.975308641975309 S 0.0 81.0 1.0 1.0 COG1487 Ribonuclease/mRNA_interferase_VapC,_contains_PIN_domain VapC 81.0 0.0 1.0 0.010435027285693 0.0491318032791254 0.0297834152824092 0.0386967759934323 0 0 0 0 K07063 0.04 0.0284900284900284 K07063; uncharacterized protein 96.0 22.0 13.0 2.0 0.709677419354839 S 20.0 11.0 1.0 1.0 COG1569 Predicted_nucleic_acid-binding_protein,_contains_PIN_domain 31.0 0.6451612903225806 0.3548387096774194 0.109436312982557 0.0447535194712958 0.0770949162269264 0.0646827935112612 0 0 0 0 K07064 0.2857142857142857 0.1339031339031339 K07064; uncharacterized protein 14.0 238.0 60.0 3.0 0.53125 V 358.0 89.0 5.0 0.839285714285714 COG1848 VapC_family_ribonuclease,_toxin_component_of_the_VapBC_toxin-antitoxin_module,_contains_PIN_domain VapC 447.0 0.8008948545861297 0.1991051454138702 0.838006955822028 0.875153164974305 0.8565800603981665 0.0371462091522769 1 1 1 1 K07065 0.1971428571428571 0.0997150997150997 K07065; uncharacterized protein 33.0 105.0 26.0 4.0 0.558510638297872 V 132.0 56.0 4.0 0.952127659574468 COG2402 Predicted_nucleic_acid-binding_protein,_contains_PIN_domain 188.0 0.7021276595744681 0.2978723404255319 0.177449165525824 0.548799496657075 0.3631243310914495 0.3713503311312509 0 0 0 0 K07066 0.12 0.0626780626780626 K07066; uncharacterized protein 89.0 52.0 12.0 3.0 0.514851485148515 S 64.0 42.0 1.0 1.0 COG2405 Predicted_nucleic_acid-binding_protein,_contains_PIN_domain 106.0 0.6037735849056604 0.3962264150943396 0.809030125749476 0.8506471440024 0.829838634875938 0.041617018252924 1 1 1 1 K07067 0.0285714285714285 0.1367521367521367 disA; diadenylate cyclase [EC:2.7.7.85] 299.0 55.0 52.0 2.0 0.948275862068966 L 10.0 48.0 1.0 1.0 COG1623 c-di-AMP_synthetase_DisA,_contains_DisA_N,_linker_and_DNA-binding_domains DisA 58.0 0.1724137931034483 0.8275862068965517 0.874828054176984 0.547958119409837 0.7113930867934104 0.326869934767147 1 1 1 1 K07068 0.7114285714285714 0.1452991452991453 K07068; uncharacterized protein 5.0 376.0 158.0 6.0 0.539454806312769 S 569.0 121.0 4.0 0.97274031563845 COG1545 Uncharacterized_OB-fold_protein,_contains_Zn-ribbon_domain 690.0 0.8246376811594203 0.1753623188405797 0.106324866178651 0.457361434573663 0.281843150376157 0.351036568395012 0 0 0 0 K07069 0.0885714285714285 0.0398860398860398 K07069; uncharacterized protein 54.0 45.0 0.0 1.0 1.0 S 31.0 14.0 1.0 1.0 COG3478 Predicted_nucleic-acid-binding_protein,_contains_Zn-ribbon_domain YpzJ 45.0 0.6888888888888889 0.3111111111111111 0.0104531514662225 0.011986578066929 0.0112198647665757 0.0015334266007064 0 0 0 0 K07070 0.0 0.0313390313390313 K07070; uncharacterized protein 61.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG3529 Predicted_nucleic-acid-binding_protein,_contains_Zn-ribbon_domain 11.0 0.0 1.0 1.14441329794918e-12 0.0006878571534586 0.0003439285773015 0.0006878571523141 0 0 0 0 K07071 0.0657142857142857 0.4358974358974359 K07071; uncharacterized protein 183.0 201.0 199.0 4.0 0.975728155339806 S 25.0 189.0 2.0 0.957943925233645 COG1090 NAD_dependent_epimerase/dehydratase_family_enzyme YfcH 214.0 0.116822429906542 0.883177570093458 0.0118850610831566 0.0818297257153004 0.0468573933992284 0.0699446646321438 0 0 0 0 K07072 0.1942857142857142 0.017094017094017 mfnF; (4-(4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl)furan-2-yl)methanamine synthase [EC:2.5.1.131] path:map00680,path:map01100,path:map01240 Methane metabolism,Metabolic pathways,Biosynthesis of cofactors 225.0 70.0 63.0 2.0 0.909090909090909 K 71.0 6.0 1.0 1.0 COG1548 Methanofuran_synthetase_MfnF,_hydantoinase/oxoprolinase_family MfnF 77.0 0.922077922077922 0.0779220779220779 0.290899896095116 0.180448329422251 0.2356741127586835 0.110451566672865 0 0 0 0 K07073 0.2371428571428571 0.0 K07073; uncharacterized protein 197.0 85.0 0.0 1.0 1.0 S 85.0 0.0 1.0 1.0 COG2413 Predicted_nucleotidyltransferase 85.0 1.0 0.0 0.0111785132883265 0.0039414470866014 0.0075599801874639 0.0072370662017251 0 0 0 0 K07074 0.04 0.1111111111111111 K07074; uncharacterized protein 107.0 56.0 49.0 2.0 0.888888888888889 S 14.0 49.0 2.0 0.857142857142857 COG3541 Predicted_nucleotidyltransferase_YcgL YcgL 63.0 0.2222222222222222 0.7777777777777778 0.205172042742053 0.241799546792532 0.2234857947672925 0.0366275040504789 0 0 0 0 K07075 0.2342857142857143 0.3532763532763532 K07075; uncharacterized protein 23.0 433.0 375.0 4.0 0.797421731123388 S 228.0 314.0 6.0 0.92633517495396 COG1669 Predicted_nucleotidyltransferase_MJ0435 MJ0435 542.0 0.4206642066420664 0.5793357933579336 0.329675661330597 0.194245224872333 0.261960443101465 0.135430436458264 0 0 0 0 K07076 0.0 0.0 K07076; uncharacterized protein 375.0 90.0 6.0 0.517241379310345 S 0.0 0.0 7.0 0.87448275862069 COG1708 Predicted_nucleotidyltransferase,_MJ0604_family MJ0604 0.0 0 0 0 0 K07077 0.0 0.0683760683760683 K07077; uncharacterized protein 543.0 24.0 22.0 2.0 0.923076923076923 S 0.0 26.0 1.0 1.0 COG3573 Predicted_oxidoreductase 26.0 0.0 1.0 0.0047717608360224 0.0346304843219345 0.0197011225789784 0.0298587234859121 0 0 0 0 K07078 0.0028571428571428 0.0541310541310541 K07078; uncharacterized protein 194.0 21.0 0.0 1.0 1.0 S 1.0 20.0 1.0 1.0 COG3560 Fatty_acid_repression_mutant_protein_(predicted_oxidoreductase) FMR2 21.0 0.0476190476190476 0.9523809523809524 0.0189933014249728 0.0522954104594502 0.0356443559422115 0.0333021090344774 0 0 0 0 K07079 0.1142857142857142 0.2108262108262108 K07079; uncharacterized protein 180.0 132.0 49.0 2.0 0.613953488372093 C 85.0 130.0 2.0 0.962790697674419 COG1453 Predicted_oxidoreductase_of_the_aldo/keto_reductase_family 215.0 0.3953488372093023 0.6046511627906976 0.751344470685865 0.509640905712282 0.6304926881990736 0.2417035649735829 1 1 1 1 K07080 0.1285714285714285 0.282051282051282 K07080; uncharacterized protein 79.0 256.0 236.0 5.0 0.895104895104895 S 61.0 225.0 1.0 1.0 COG2358 TRAP-type_uncharacterized_transport_system,_periplasmic_component Imp 286.0 0.2132867132867132 0.7867132867132867 0.0112570330673641 0.0793443177623603 0.0453006754148622 0.0680872846949962 0 0 0 0 K07081 0.0 0.0341880341880341 K07081; putative periplasmic solute-binding protein 231.0 9.0 6.0 2.0 0.75 E 0.0 12.0 1.0 1.0 COG1427 Chorismate_dehydratase_(menaquinone_biosynthesis,_futalosine_pathway) MqnA 12.0 0.0 1.0 0.0213012916413536 0.389446887225692 0.2053740894335227 0.3681455955843384 0 0 0 0 K07082 0.0 0.8376068376068376 K07082; UPF0755 protein 69.0 286.0 274.0 5.0 0.910828025477707 S 0.0 314.0 5.0 0.984076433121019 COG1559 Endolytic_transglycosylase_MltG,_terminates_peptidoglycan_polymerization MltG 314.0 0.0 1.0 0.0147046214552174 0.260419633655201 0.1375621275552092 0.2457150121999836 0 0 0 0 K07083 0.0 0.0142450142450142 K07083; putative periplasmic solute-binding protein 259.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG2107 1,4-dihydroxy-6-naphtoate_synthase_(menaquinone_biosynthesis,_futalosine_pathway) MqnD 5.0 0.0 1.0 3.21455357558695e-12 6.64173208110273e-12 4.92814282834484e-12 3.42717850551578e-12 0 0 0 0 K07084 0.0 0.0655270655270655 yuiF; putative amino acid transporter 407.0 23.0 0.0 1.0 1.0 S 0.0 23.0 1.0 1.0 COG2056 Predicted_histidine_transporter_YuiF,_NhaC_family YuiF 23.0 0.0 1.0 0.0115925787357413 0.715471908592377 0.3635322436640591 0.7038793298566357 0 0 0 0 K07085 0.0057142857142857 0.150997150997151 K07085; putative transport protein 377.0 40.0 26.0 3.0 0.597014925373134 P 2.0 65.0 4.0 0.432835820895522 COG0569 Trk/Ktr_K+_transport_system_regulatory_component_TrkA/KtrA/KtrC,_RCK_domain TrkA 67.0 0.0298507462686567 0.9701492537313432 0.0173781580216736 0.489210897534805 0.2532945277782393 0.4718327395131314 0 0 0 0 K07086 0.0171428571428571 0.1082621082621082 K07086; uncharacterized protein 292.0 54.0 0.0 1.0 1.0 S 6.0 48.0 1.0 1.0 COG3329 Uncharacterized_conserved_protein_Alr0986 54.0 0.1111111111111111 0.8888888888888888 0.0105886339698056 0.0350931666861257 0.0228409003279656 0.0245045327163201 0 0 0 0 K07087 0.0828571428571428 0.0 K07087; uncharacterized protein 272.0 29.0 0.0 1.0 1.0 S 34.0 0.0 3.0 0.852941176470588 COG3368 Predicted_permease 34.0 1.0 0.0 0.852884947579641 0.932762671003235 0.892823809291438 0.079877723423594 0 0 1 1 K07088 0.2685714285714285 0.5356125356125356 51.0 426.0 425.0 2.0 0.997658079625293 S 114.0 313.0 1.0 1.0 COG0679 Predicted_permease,_AEC_(auxin_efflux_carrier)_family YfdV 427.0 0.2669789227166276 0.7330210772833724 0.394687053990424 0.215255380903382 0.304971217446903 0.1794316730870419 0 0 0 0 K07089 0.2828571428571428 0.49002849002849 K07089; uncharacterized protein 163.0 382.0 360.0 2.0 0.945544554455446 S 147.0 266.0 6.0 0.929782082324455 COG0701 Uncharacterized_membrane_protein_YraQ,_UPF0718_family YraQ 413.0 0.3559322033898305 0.6440677966101694 0.155787034456087 0.818748911563591 0.487267973009839 0.662961877107504 0 0 0 0 K07090 0.0 0.0 K07090; uncharacterized protein 1337.0 1292.0 5.0 0.953637660485021 S 0.0 0.0 8.0 0.960142348754448 COG0730 Sulfite_exporter_TauE/SafE/YfcA_and_related_permeases,_UPF0721_family TauE 0.0 0 0 0 0 K07091 0.0 0.5071225071225072 lptF; lipopolysaccharide export system permease protein path:map02010 ABC transporters 154.0 169.0 149.0 2.0 0.894179894179894 S 0.0 189.0 1.0 1.0 COG0795 Lipopolysaccharide_export_LptBFGC_system,_permease_protein_LptF LptF 189.0 0.0 1.0 0.386418948613105 0.0356292034174348 0.2110240760152699 0.3507897451956702 0 0 0 0 K07092 0.1771428571428571 0.0313390313390313 K07092; uncharacterized protein 40.0 55.0 30.0 2.0 0.6875 O 95.0 15.0 2.0 0.727272727272727 COG2044 Predicted_peroxiredoxin,_DsrE/DsrF-like_family 110.0 0.8636363636363636 0.1363636363636363 0.610727649147905 0.710312729155247 0.660520189151576 0.099585080007342 0 1 0 1 K07093 0.02 0.2592592592592592 K07093; uncharacterized protein 170.0 112.0 104.0 8.0 0.805755395683453 S 7.0 132.0 8.0 0.913669064748201 COG3211 Secreted_phosphatase,_PhoX_family PhoX 139.0 0.0503597122302158 0.9496402877697842 0.0010864457254347 0.131507146958753 0.0662967963420938 0.1304207012333183 0 0 0 0 K07094 0.0057142857142857 0.0997150997150997 pcrB; heptaprenylglyceryl phosphate synthase [EC:2.5.1.-] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 183.0 37.0 0.0 1.0 1.0 I 2.0 35.0 1.0 1.0 COG1646 Glycerol-1-phosphate_heptaprenyltransferase PcrB 37.0 0.054054054054054 0.945945945945946 0.0025453709519296 0.0197742947639196 0.0111598328579246 0.01722892381199 0 0 0 0 K07095 0.5085714285714286 0.4700854700854701 K07095; uncharacterized protein 27.0 508.0 0.0 1.0 1.0 S 296.0 212.0 1.0 1.0 COG0622 Predicted_phosphodiesterase,_calcineurin_family YfcE 508.0 0.5826771653543307 0.4173228346456692 0.0335649639154722 0.0333000294429948 0.0334324966792335 0.0002649344724773 0 0 0 0 K07096 0.5885714285714285 0.0598290598290598 K07096; uncharacterized protein 50.0 259.0 225.0 3.0 0.822222222222222 S 289.0 25.0 2.0 0.980952380952381 COG2129 Predicted_phosphoesterase,_related_to_the_Icc_protein 314.0 0.9203821656050956 0.0796178343949044 0.737691127590469 0.73158277774596 0.7346369526682145 0.0061083498445089 0 1 0 1 K07097 0.3142857142857143 0.0256410256410256 K07097; uncharacterized protein 130.0 134.0 0.0 1.0 1.0 S 124.0 9.0 1.0 1.0 COG2404 Oligoribonuclease_NrnA/c-di-AMP_phosphodiesterase_DhhP,_DHH_superfamily DhhP 133.0 0.9323308270676692 0.0676691729323308 0.0063571357529168 0.0996905608307436 0.0530238482918302 0.0933334250778268 0 0 0 0 K07098 0.0828571428571428 0.5470085470085471 K07098; uncharacterized protein 40.0 286.0 277.0 5.0 0.916666666666667 S 39.0 273.0 3.0 0.974358974358975 COG1408 Predicted_phosphohydrolase,_MPP_superfamily YaeI 312.0 0.125 0.875 0.0110113887921397 0.20927039143787 0.1101408901150048 0.1982590026457303 0 0 0 0 K07099 0.0 0.0826210826210826 K07099; uncharacterized protein 186.0 29.0 0.0 1.0 1.0 S 0.0 29.0 1.0 1.0 COG1768 Predicted_phosphohydrolase,_DR1119_family,_metallophosphatase_superfamily DR1119 29.0 0.0 1.0 0.006558154038082 0.035865337983487 0.0212117460107845 0.0293071839454049 0 0 0 0 K07100 0.1 0.1538461538461538 K07100; putative phosphoribosyl transferase 126.0 57.0 25.0 5.0 0.5 S 42.0 70.0 5.0 0.798245614035088 COG1926 Predicted_phosphoribosyltransferase 112.0 0.375 0.625 0.0211614281109194 0.155700573930002 0.0884310010204607 0.1345391458190826 0 0 0 0 K07101 0.5542857142857143 0.1481481481481481 K07101; uncharacterized protein 71.0 280.0 229.0 2.0 0.845921450151057 F 275.0 56.0 2.0 0.963746223564955 COG2236 Hypoxanthine_phosphoribosyltransferase Hpt1 331.0 0.8308157099697885 0.1691842900302115 0.963530364048607 0.634428646270281 0.7989795051594439 0.3291017177783261 1 1 1 1 K07102 0.0028571428571428 0.3076923076923077 amgK; N-acetylmuramate 1-kinase [EC:2.7.1.221] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 10.0 119.0 111.0 2.0 0.937007874015748 S 1.0 123.0 5.0 0.559055118110236 COG3178 Predicted_phosphotransferase,_aminoglycoside/choline_kinase_(APH/ChoK)_family 124.0 0.0080645161290322 0.9919354838709676 0.0182963770731287 0.019208664753042 0.0187525209130853 0.0009122876799133 0 0 0 0 K07103 0.4142857142857143 0.0 K07103; uncharacterized protein 153.0 105.0 74.0 3.0 0.724137931034483 S 159.0 0.0 1.0 1.0 COG2150 Predicted_regulator_of_amino_acid_metabolism,_contains_ACT_domain 159.0 1.0 0.0 0.341933363280958 0.824176840941742 0.58305510211135 0.482243477660784 0 0 0 0 K07104 0.1228571428571428 0.1481481481481481 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] path:map00361,path:map00362,path:map00622,path:map00643,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Xylene degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 105.0 73.0 39.0 3.0 0.669724770642202 S 48.0 61.0 1.0 1.0 COG2514 Catechol-2,3-dioxygenase CatE 109.0 0.4403669724770642 0.5596330275229358 0.0078532503771355 0.309971831193228 0.1589125407851817 0.3021185808160925 0 0 0 0 K07105 0.0228571428571428 0.1139601139601139 K07105; uncharacterized protein 147.0 30.0 22.0 5.0 0.6 S 8.0 42.0 3.0 0.94 COG1827 Transcriptional_regulator_of_NAD_metabolism,_contains_HTH_and_3H_domains NiaR 50.0 0.16 0.84 0.0337496051516182 0.0602971311622805 0.0470233681569493 0.0265475260106623 0 0 0 0 K07106 0.0142857142857142 0.3532763532763532 murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 188.0 80.0 33.0 5.0 0.533333333333333 G 5.0 145.0 4.0 0.92 COG2103 N-acetylmuramic_acid_6-phosphate_(MurNAc-6-P)_etherase MurQ 150.0 0.0333333333333333 0.9666666666666668 0.113407870456297 0.612646892879883 0.36302738166809 0.4992390224235861 0 0 0 0 K07107 0.2942857142857142 0.7207977207977208 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] 7.0 595.0 552.0 4.0 0.923913043478261 S 117.0 522.0 1.0 1.0 COG0824 Acyl-CoA_thioesterase_FadM FadM 639.0 0.1830985915492957 0.8169014084507042 0.01795150631986 0.0621324772012183 0.0400419917605391 0.0441809708813583 0 0 0 0 K07108 0.4914285714285714 0.0113960113960113 K07108; uncharacterized protein 44.0 124.0 21.0 3.0 0.52991452991453 K 230.0 4.0 2.0 0.978632478632479 COG2522 Predicted_transcriptional_regulator,_contains_XRE-type_HTH_domain AF0184 234.0 0.9829059829059827 0.017094017094017 0.494870892186148 0.944067614102772 0.71946925314446 0.4491967219166239 0 0 0 0 K07109 0.0 0.0199430199430199 K07109; uncharacterized protein 162.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3054 Predicted_transcriptional_regulator_YtfJ YtfJ 7.0 0.0 1.0 0.0337535266299646 0.0797687104684915 0.056761118549228 0.0460151838385269 0 0 0 0 K07110 0.0 0.1424501424501424 ramB; XRE family transcriptional regulator, fatty acid utilization regulator 119.0 68.0 66.0 3.0 0.957746478873239 K 0.0 71.0 6.0 0.549295774647887 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 71.0 0.0 1.0 0.0073172033136878 0.0509997529435807 0.0291584781286342 0.0436825496298929 0 0 0 0 K07111 0.0257142857142857 0.0 K07111; uncharacterized protein 203.0 13.0 0.0 1.0 1.0 S 13.0 0.0 1.0 1.0 COG1800 Predicted_transglutaminase-like_protease,_UPF0252_family 13.0 1.0 0.0 0.781252998301567 0.89443893944165 0.8378459688716084 0.1131859411400829 0 0 1 1 K07112 0.2457142857142857 0.4131054131054131 K07112; uncharacterized protein 24.0 471.0 460.0 7.0 0.94578313253012 S 188.0 349.0 8.0 0.95903165735568 COG2391 Uncharacterized_membrane_protein_YedE/YeeE,_contains_two_sulfur_transport_domains YedE 537.0 0.3500931098696462 0.6499068901303539 0.0803494798741154 0.0384422929226331 0.0593958863983742 0.0419071869514823 0 0 0 0 K07113 0.14 0.2649572649572649 fxsA; UPF0716 protein FxsA 84.0 142.0 0.0 1.0 1.0 S 49.0 93.0 1.0 1.0 COG3030 FxsA_protein_affecting_phage_T7_exclusion_by_the_F_plasmid,_UPF0716_family FxsA 142.0 0.3450704225352112 0.6549295774647887 0.0011242827497433 0.0024206401218272 0.0017724614357852 0.0012963573720839 0 0 0 0 K07114 0.4 0.5925925925925926 yfbK; Ca-activated chloride channel homolog 5.0 512.0 445.0 15.0 0.644025157232704 S 210.0 542.0 24.0 0.810062893081761 COG2304 Secreted_protein_containing_bacterial_Ig-like_domain_and_vWFA_domain YfbK 752.0 0.2792553191489361 0.7207446808510638 0.090169656944426 0.253035785860349 0.1716027214023875 0.162866128915923 0 0 0 0 K07115 0.0085714285714285 0.131054131054131 rlmJ; 23S rRNA (adenine2030-N6)-methyltransferase [EC:2.1.1.266] 206.0 28.0 13.0 3.0 0.549019607843137 S 3.0 48.0 1.0 1.0 COG2961 23S_rRNA_A2030_N6-methylase_RlmJ RlmJ 51.0 0.0588235294117647 0.9411764705882352 0.0037515032091167 0.007946351445808 0.0058489273274623 0.0041948482366913 0 0 0 0 K07116 0.0 0.094017094017094 pvdQ, quiP; acyl-homoserine-lactone acylase [EC:3.5.1.97] 403.0 31.0 27.0 3.0 0.81578947368421 S 0.0 38.0 1.0 1.0 COG2366 Acyl-homoserine_lactone_(AHL)_acylase_PvdQ PvdQ 38.0 0.0 1.0 0.0074020577441169 0.0278435701559075 0.0176228139500122 0.0204415124117906 0 0 0 0 K07117 0.0742857142857142 0.1538461538461538 K07117; uncharacterized protein 41.0 73.0 53.0 2.0 0.78494623655914 S 28.0 65.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 93.0 0.3010752688172043 0.6989247311827957 0.0106890262326161 0.170689577292918 0.090689301762767 0.1600005510603019 0 0 0 0 K07118 0.0285714285714285 0.1139601139601139 K07118; uncharacterized protein 163.0 50.0 40.0 3.0 0.793650793650794 S 11.0 52.0 2.0 0.793650793650794 COG2910 Putative_NADH-flavin_reductase YwnB 63.0 0.1746031746031746 0.8253968253968254 0.0241160383372148 0.0150501172280106 0.0195830777826127 0.0090659211092042 0 0 0 0 K07119 0.0971428571428571 0.2136752136752136 PTGR3, ZADH2; prostaglandin reductase 3 [EC:1.3.1.48] 260.0 125.0 116.0 3.0 0.925925925925926 S 34.0 101.0 1.0 1.0 COG2130 NADPH-dependent_curcumin_reductase_CurA CurA 135.0 0.2518518518518518 0.7481481481481481 0.0103274859194212 0.067690910162727 0.0390091980410741 0.0573634242433058 0 0 0 0 K07120 0.0 0.1595441595441595 K07120; uncharacterized protein 240.0 73.0 72.0 2.0 0.986486486486486 S 0.0 74.0 2.0 0.959459459459459 COG3180 Uncharacterized_membrane_protein_AbrB,_regulator_of_aidB_expression AbrB 74.0 0.0 1.0 0.0111271871245761 0.0504156254129554 0.0307714062687657 0.0392884382883793 0 0 0 0 K07121 0.0 0.1139601139601139 K07121; uncharacterized protein 205.0 24.0 7.0 2.0 0.585365853658537 M 0.0 41.0 3.0 0.585365853658537 COG3107 Outer_membrane_lipoprotein_LpoA,_binds_and_activates_PBP1a LpoA 41.0 0.0 1.0 0.00367203808342 0.0097114946327911 0.0066917663581055 0.0060394565493711 0 0 0 0 K07122 0.0 0.0911680911680911 mlaB; phospholipid transport system transporter-binding protein path:map02010 ABC transporters 38.0 24.0 14.0 3.0 0.685714285714286 S 0.0 35.0 3.0 0.685714285714286 COG3113 Binding_protein_subunit_MlaB_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla,_contains_STAS_domain MlaB 35.0 0.0 1.0 0.0046047299611048 0.0145942657336784 0.0095994978473916 0.0099895357725736 0 0 0 0 K07123 0.2457142857142857 0.0455840455840455 K07123; uncharacterized protein 206.0 105.0 96.0 3.0 0.91304347826087 S 98.0 17.0 2.0 0.921739130434783 COG2144 Selenophosphate_synthetase-related_protein 115.0 0.8521739130434782 0.1478260869565217 0.072330812425179 0.250660684644423 0.1614957485348009 0.1783298722192439 0 0 0 0 K07124 0.1342857142857142 0.4131054131054131 K07124; uncharacterized protein 92.0 238.0 222.0 5.0 0.904942965779468 S 50.0 213.0 1.0 1.0 COG0300 Short-chain_dehydrogenase YqjQ 263.0 0.1901140684410646 0.8098859315589354 0.0172483493648277 0.234768658710731 0.1260085040377793 0.2175203093459033 0 0 0 0 K07125 0.0028571428571428 0.0113960113960113 K07125; uncharacterized protein 133.0 5.0 0.0 1.0 1.0 S 1.0 4.0 1.0 1.0 COG2166 Sulfur_transfer_protein_SufE,_Fe-S_cluster_assembly SufE 5.0 0.2 0.8 0.0717910085163194 0.16095082601855 0.1163709172674346 0.0891598175022305 0 0 0 0 K07126 0.0 0.0 K07126; uncharacterized protein 218.0 199.0 14.0 0.71947194719472 S 0.0 0.0 28.0 0.688311688311688 COG0790 TPR_repeat TPR 0.0 0 0 0 0 K07127 0.0142857142857142 0.1709401709401709 uraH, pucM, hiuH; 5-hydroxyisourate hydrolase [EC:3.5.2.17] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 87.0 76.0 72.0 3.0 0.926829268292683 S 5.0 77.0 2.0 0.853658536585366 COG2351 5-hydroxyisourate_hydrolase_(purine_catabolism),_transthyretin-related_family HiuH 82.0 0.0609756097560975 0.9390243902439024 0.0069903794710022 0.0206875379406114 0.0138389587058068 0.0136971584696092 0 0 0 0 K07128 0.0 0.0 K07128; uncharacterized protein 21.0 20.0 2.0 0.954545454545455 E 0.0 0.0 1.0 1.0 COG2401 ABC-type_ATPase_fused_to_a_predicted_acetyltransferase_domain MK0520 0.0 0 0 0 0 K07129 0.52 0.017094017094017 K07129; uncharacterized protein 217.0 191.0 0.0 1.0 1.0 S 185.0 6.0 1.0 1.0 COG2108 Uncharacterized_radical_SAM_domain-containing_protein 191.0 0.9685863874345548 0.031413612565445 0.119403477186395 0.941160704930904 0.5302820910586495 0.821757227744509 0 0 0 0 K07130 0.1171428571428571 0.1253561253561253 kynB; arylformamidase [EC:3.5.1.9] path:map00380,path:map00630,path:map01100,path:map01240 Tryptophan metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of cofactors 115.0 61.0 40.0 4.0 0.648936170212766 S 46.0 48.0 2.0 0.98936170212766 COG1878 Kynurenine_formamidase 94.0 0.4893617021276595 0.5106382978723404 0.614234980342638 0.66425065129921 0.639242815820924 0.050015670956572 0 1 0 1 K07131 0.1971428571428571 0.1225071225071225 K07131; uncharacterized protein 49.0 261.0 230.0 3.0 0.841935483870968 S 214.0 96.0 1.0 1.0 COG2018 Predicted_regulator_of_Ras-like_GTPase_activity,_Roadblock/LC7/MglB_family 310.0 0.6903225806451613 0.3096774193548387 0.826318483911892 0.961055270642301 0.8936868772770965 0.134736786730409 1 1 1 1 K07132 0.0 0.0484330484330484 MuB; Enterobacteriaceae phage ATP-dependent target DNA activator 133.0 14.0 9.0 3.0 0.7 S 0.0 20.0 2.0 0.8 COG2842 Bacteriophage_DNA_transposition_protein,_AAA+_family_ATPase 20.0 0.0 1.0 0.0427828230160056 0.0998235663301536 0.0713031946730796 0.057040743314148 0 0 0 0 K07133 0.3714285714285714 0.3732193732193732 K07133; uncharacterized protein 31.0 849.0 739.0 4.0 0.869877049180328 S 487.0 443.0 2.0 0.996926229508197 COG1373 Predicted_ATPase,_AAA+_superfamily 930.0 0.5236559139784946 0.4763440860215053 0.575103512586108 0.87880936940325 0.726956440994679 0.303705856817142 0 1 0 1 K07134 0.0771428571428571 0.0 K07134; uncharacterized protein 203.0 28.0 0.0 1.0 1.0 S 28.0 0.0 1.0 1.0 COG1365 Predicted_ATPase,_PP-loop_superfamily 28.0 1.0 0.0 0.137030928955594 0.148410736421655 0.1427208326886245 0.011379807466061 0 0 0 0 K07135 0.1057142857142857 0.0 K07135; uncharacterized protein 197.0 40.0 0.0 1.0 1.0 S 40.0 0.0 1.0 1.0 COG2517 Predicted_RNA-binding_protein,_contains_C-terminal_EMAP_domain 40.0 1.0 0.0 0.622437361947079 0.870364095570955 0.746400728759017 0.2479267336238759 0 0 0 1 K07136 0.0 0.0484330484330484 K07136; uncharacterized protein 109.0 19.0 0.0 1.0 1.0 S 0.0 19.0 1.0 1.0 COG3788 Uncharacterized_membrane_protein_YecN,_MAPEG_domain YecN 19.0 0.0 1.0 0.0085238222978507 0.0251392187686977 0.0168315205332741 0.016615396470847 0 0 0 0 K07137 0.2971428571428571 0.2991452991452991 K07137; uncharacterized protein 276.0 217.0 202.0 3.0 0.923404255319149 S 107.0 128.0 1.0 1.0 COG2509 FAD-dependent_dehydrogenase 235.0 0.4553191489361702 0.5446808510638298 0.855313863769099 0.853386392595932 0.8543501281825154 0.001927471173167 1 1 1 1 K07138 0.2314285714285714 0.1566951566951566 K07138; uncharacterized protein 209.0 159.0 0.0 1.0 1.0 C 104.0 66.0 1.0 1.0 COG2768 Uncharacterized_Fe-S_cluster_protein 170.0 0.611764705882353 0.388235294117647 0.926991519845283 0.984215883334977 0.95560370159013 0.0572243634896939 1 1 1 1 K07139 0.0371428571428571 0.2649572649572649 K07139; uncharacterized protein 230.0 102.0 95.0 2.0 0.935779816513762 S 13.0 96.0 1.0 1.0 COG1242 Radical_SAM_superfamily_enzyme YhcC 109.0 0.1192660550458715 0.8807339449541285 0.0879960816302142 0.748590246984932 0.4182931643075731 0.6605941653547178 0 0 0 0 K07140 0.1114285714285714 0.2051282051282051 K07140; uncharacterized protein 116.0 117.0 107.0 3.0 0.9140625 S 41.0 87.0 3.0 0.9453125 COG3217 N-hydroxylaminopurine_reductase_subunit_YcbX,_contains_MOSC_domain YcbX 128.0 0.3203125 0.6796875 0.0061684594555154 0.003710888224344 0.0049396738399297 0.0024575712311714 0 0 0 0 K07141 0.1942857142857142 0.3732193732193732 mocA; molybdenum cofactor cytidylyltransferase [EC:2.7.7.76] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 49.0 173.0 148.0 4.0 0.789954337899543 S 69.0 144.0 5.0 0.949771689497717 COG2068 CTP:molybdopterin_cytidylyltransferase_MocA MocA 213.0 0.323943661971831 0.676056338028169 0.299724152236096 0.827240426347539 0.5634822892918175 0.527516274111443 0 0 0 0 K07142 0.6028571428571429 0.0 mptE; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 117.0 214.0 0.0 1.0 1.0 H 214.0 0.0 1.0 1.0 COG1634 6-hydroxymethyl-7,8-dihydropterin_pyrophosphokinase_MptE_(tetrahydrofolate_and_tetrahydromethanopterin_biosynthesis) FolK 214.0 1.0 0.0 0.0086534942741426 0.254377844693926 0.1315156694840343 0.2457243504197833 0 0 0 0 K07143 0.3771428571428571 0.0 K07143; UPF0148 protein 54.0 135.0 0.0 1.0 1.0 S 135.0 0.0 1.0 1.0 COG1645 Uncharacterized_Zn-finger_containing_protein,_UPF0148_family 135.0 1.0 0.0 0.0412282728471935 0.0550016838409246 0.048114978344059 0.0137734109937311 0 0 0 0 K07144 0.1914285714285714 0.0056980056980056 mfnE; 5-(aminomethyl)-3-furanmethanol phosphate kinase [EC:2.7.4.31] path:map00680,path:map01100,path:map01240 Methane metabolism,Metabolic pathways,Biosynthesis of cofactors 140.0 67.0 0.0 1.0 1.0 S 69.0 2.0 1.0 1.0 COG2054 5-(aminomethyl)-3-furanmethanol-phosphate_kinase_MfnE_(methanofuran_biosynthesis) MfnE 71.0 0.971830985915493 0.028169014084507 0.926921750994313 0.930382336348887 0.9286520436716 0.003460585354574 0 0 1 1 K07145 0.0028571428571428 0.0398860398860398 isdG, isdI; heme oxygenase (staphylobilin-producing) [EC:1.14.99.48] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 77.0 15.0 13.0 2.0 0.882352941176471 S 1.0 16.0 1.0 1.0 COG2329 Heme-degrading_monooxygenase_HmoA_and_related_ABM_domain_proteins HmoA 17.0 0.0588235294117647 0.9411764705882352 0.0385736719768516 0.127849494256625 0.0832115831167383 0.0892758222797734 0 0 0 0 K07146 0.0514285714285714 0.2792022792022792 K07146; UPF0176 protein 183.0 94.0 73.0 3.0 0.796610169491525 S 18.0 100.0 4.0 0.88135593220339 COG1054 tRNA_U34_5'-hydroxylase_TrhO,_rhodanese_family TrhO 118.0 0.1525423728813559 0.847457627118644 0.0024692758740875 0.0372139267378057 0.0198416013059466 0.0347446508637182 0 0 0 0 K07147 0.0 0.1908831908831909 msrP; methionine sulfoxide reductase catalytic subunit [EC:1.8.-.-] 228.0 37.0 4.0 3.0 0.486842105263158 C 0.0 76.0 1.0 1.0 COG2041 Molybdopterin-dependent_catalytic_subunit_of_periplasmic_DMSO/TMAO_and_protein-methionine-sulfoxide_reductases MsrP 76.0 0.0 1.0 0.0109905801441842 0.0283647302004792 0.0196776551723317 0.017374150056295 0 0 0 0 K07148 0.0514285714285714 0.1367521367521367 K07148; uncharacterized protein 207.0 77.0 74.0 2.0 0.9625 S 19.0 61.0 1.0 1.0 COG2311 Uncharacterized_membrane_protein_YeiB YeiB 80.0 0.2375 0.7625 0.0153393817861652 0.253998786048648 0.1346690839174066 0.2386594042624828 0 0 0 0 K07149 0.02 0.0797720797720797 K07149; uncharacterized protein 164.0 38.0 33.0 2.0 0.883720930232558 S 8.0 36.0 2.0 0.977272727272727 COG2364 Uncharacterized_membrane_protein_YczE YczE 44.0 0.1818181818181818 0.8181818181818182 0.0439201975558976 0.645256666785594 0.3445884321707458 0.6013364692296964 0 0 0 0 K07150 0.0371428571428571 0.2393162393162393 K07150; uncharacterized protein 202.0 102.0 0.0 1.0 1.0 S 13.0 89.0 1.0 1.0 COG1811 Uncharacterized_membrane_protein_YqgA,_affects_biofilm_formation YqgA 102.0 0.1274509803921568 0.8725490196078431 0.701549830707058 0.539590615723151 0.6205702232151045 0.1619592149839069 0 1 0 1 K07151 0.7342857142857143 0.0797720797720797 STT3; dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18] path:map00510,path:map00513,path:map01100,path:map04141 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways,Protein processing in endoplasmic reticulum 74.0 170.0 38.0 7.0 0.404761904761905 M 384.0 33.0 7.0 0.869047619047619 COG1287 Asparagine_N-glycosylation_enzyme,_membrane_subunit_Stt3 Stt3 417.0 0.920863309352518 0.079136690647482 0.590464455060377 0.702685312280368 0.6465748836703725 0.1122208572199909 0 1 0 1 K07152 0.1742857142857143 0.3874643874643874 SCO1; protein SCO1 18.0 301.0 271.0 6.0 0.864942528735632 S 91.0 257.0 7.0 0.951149425287356 COG1999 Cytochrome_oxidase_Cu_insertion_factor,_SCO1/SenC/PrrC_family Sco1 348.0 0.2614942528735632 0.7385057471264368 0.0026498028019393 0.0070789917129983 0.0048643972574688 0.004429188911059 0 0 0 0 K07153 0.0 0.0512820512820512 hflD; high frequency lysogenization protein 191.0 18.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG2915 Regulator_of_phage_lambda_lysogenization_HflD,_binds_to_CII_and_stimulates_its_degradation HflD 18.0 0.0 1.0 0.0012432471281832 0.0012061010867958 0.0012246741074895 3.714604138740007e-05 0 0 0 0 K07154 0.0028571428571428 0.2535612535612536 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 58.0 171.0 164.0 2.0 0.960674157303371 S 2.0 172.0 2.0 0.98876404494382 COG3550 Serine/threonine_protein_kinase_HipA,_toxin_component_of_the_HipAB_toxin-antitoxin_module HipA 174.0 0.0114942528735632 0.9885057471264368 0.0120356387778366 0.0457305623794422 0.0288831005786394 0.0336949236016056 0 0 0 0 K07155 0.0 0.0113960113960113 qodI; quercetin 2,3-dioxygenase [EC:1.13.11.24] 128.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 4.0 0.0 1.0 0.0418821990252556 0.0979793860753518 0.0699307925503037 0.0560971870500962 0 0 0 0 K07156 0.0028571428571428 0.1538461538461538 copC, pcoC; copper resistance protein C 36.0 48.0 31.0 3.0 0.666666666666667 S 1.0 71.0 2.0 0.944444444444444 COG2372 Copper-binding_protein_CopC_(methionine-rich) CopC 72.0 0.0138888888888888 0.9861111111111112 0.0054305283620563 0.0314222034127902 0.0184263658874232 0.0259916750507339 0 0 0 0 K07157 0.04 0.2905982905982906 K07157; uncharacterized protein 77.0 118.0 0.0 1.0 1.0 S 14.0 104.0 2.0 0.898305084745763 COG2802 Uncharacterized_conserved_protein,_LON_N-like_domain,_ASCH/PUA-like_superfamily LON/PUA 118.0 0.1186440677966101 0.8813559322033898 0.0034521396509164 0.601589392349443 0.3025207660001797 0.5981372526985266 0 0 0 0 K07158 0.7685714285714286 0.0 K07158; uncharacterized protein 49.0 172.0 73.0 2.0 0.634686346863469 V 271.0 0.0 1.0 1.0 COG1412 rRNA-processing_protein_FCF1 Fcf1 271.0 1.0 0.0 0.842638438116335 0.410664435025067 0.626651436570701 0.431974003091268 0 0 1 1 K07159 0.7314285714285714 0.0256410256410256 K07159; uncharacterized protein 127.0 319.0 0.0 1.0 1.0 S 308.0 11.0 1.0 1.0 COG2047 Proteasome_assembly_chaperone_(PAC2)_family_protein 319.0 0.9655172413793104 0.0344827586206896 0.868697916745018 0.95159798027964 0.9101479485123288 0.082900063534622 1 1 1 1 K07160 0.0428571428571428 0.3162393162393162 pxpA; 5-oxoprolinase (ATP-hydrolysing) subunit A [EC:3.5.2.9] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 217.0 131.0 121.0 2.0 0.929078014184397 S 16.0 125.0 2.0 0.971631205673759 COG1540 5-oxoprolinase_subunit_A PxpA 141.0 0.1134751773049645 0.8865248226950354 0.344476598613708 0.868051710333141 0.6062641544734245 0.5235751117194329 0 0 0 0 K07161 0.0514285714285714 0.1794871794871795 K07161; uncharacterized protein 172.0 106.0 104.0 3.0 0.972477064220183 S 23.0 86.0 3.0 0.981651376146789 COG3552 Uncharacterized_protein_CoxE,_contains_von_Willebrand_factor_type_A_(vWA)_domain CoxE 109.0 0.2110091743119266 0.7889908256880734 0.0023620018751343 0.347150932293441 0.1747564670842876 0.3447889304183067 0 0 0 0 K07162 0.04 0.0142450142450142 K07162; uncharacterized protein 77.0 18.0 17.0 2.0 0.947368421052632 S 14.0 5.0 1.0 1.0 COG2158 Uncharacterized_conserved_protein,_contains_a_Zn-finger-like_domain 19.0 0.7368421052631579 0.2631578947368421 0.009771691069425 0.0185021401773762 0.0141369156234006 0.0087304491079512 0 0 0 0 K07163 0.3942857142857143 0.0 K07163; uncharacterized protein 63.0 89.0 38.0 3.0 0.626760563380282 S 142.0 0.0 3.0 0.957746478873239 COG3364 Predicted__nucleic_acid-binding_protein,_contains_Zn-ribbon_domain 142.0 1.0 0.0 0.71182543242904 0.863323534189347 0.7875744833091936 0.1514981017603071 0 0 0 1 K07164 0.0 0.4415954415954416 K07164; uncharacterized protein 70.0 140.0 138.0 2.0 0.985915492957746 S 0.0 161.0 2.0 0.975155279503106 COG1579 Predicted_nucleic_acid-binding_protein_DR0291,_contains_C4-type_Zn-ribbon_domain DR0291 161.0 0.0 1.0 0.0065231932789667 0.664844223899604 0.3356837085892853 0.6583210306206373 0 0 0 0 K07165 0.0 0.0911680911680911 fecR; transmembrane sensor path:map02020 Two-component system 152.0 69.0 68.0 3.0 0.971830985915493 PT 0.0 71.0 3.0 0.971830985915493 COG3712 Periplasmic_ferric-dicitrate_binding_protein_FecR,_regulates_iron_transport FecR 71.0 0.0 1.0 0.0048034726370358 0.0090542820017877 0.0069288773194117 0.0042508093647519 0 0 0 0 K07166 0.1514285714285714 0.1082621082621082 K07166; ACT domain-containing protein 84.0 92.0 0.0 1.0 1.0 T 54.0 38.0 1.0 1.0 COG3830 ACT_domain,_binds_amino_acids_and_other_small_ligands ACT 92.0 0.5869565217391305 0.4130434782608695 0.468591550769865 0.825571264584008 0.6470814076769364 0.356979713814143 0 0 0 0 K07167 0.0028571428571428 0.0712250712250712 chrR; putative transcriptional regulator 163.0 27.0 0.0 1.0 1.0 T 1.0 26.0 1.0 1.0 COG3806 Anti-sigma_factor_ChrR,_cupin_superfamily ChrR 27.0 0.037037037037037 0.9629629629629628 0.0035454408160505 0.0093269596956877 0.0064362002558691 0.0057815188796371 0 0 0 0 K07168 0.0 0.0 K07168; CBS domain-containing membrane protein 36.0 25.0 2.0 0.765957446808511 T 0.0 0.0 2.0 0.74468085106383 COG3448 CBS-domain-containing_membrane_protein 0.0 0 0 0 0 K07169 0.0 0.0256410256410256 K07169; FHA domain-containing protein 112.0 12.0 11.0 2.0 0.923076923076923 T 0.0 13.0 2.0 0.923076923076923 COG1716 Forkhead_associated_(FHA)_domain,_binds_pSer,_pThr,_pTyr FHA 13.0 0.0 1.0 0.0073317617834319 0.0122113749954621 0.009771568389447 0.0048796132120302 0 0 0 0 K07171 0.2457142857142857 0.3789173789173789 mazF, ndoA, chpA; mRNA interferase MazF [EC:3.1.-.-] 11.0 256.0 126.0 5.0 0.592592592592593 T 121.0 310.0 4.0 0.931662870159453 COG2337 mRNA-degrading_endonuclease_MazF,_toxin_component_of_the_MazEF_toxin-antitoxin_module MazF 431.0 0.2807424593967517 0.7192575406032483 0.014333561114729 0.0426085168691438 0.0284710389919363 0.0282749557544148 0 0 0 0 K07172 0.0114285714285714 0.1908831908831909 mazE, chpAI; antitoxin MazE 39.0 76.0 66.0 3.0 0.873563218390805 T 5.0 82.0 2.0 0.988505747126437 COG2336 Antitoxin_component_MazE_of_the_MazEF_toxin-antitoxin_module MazE 87.0 0.057471264367816 0.942528735632184 0.020451150742444 0.0504327538291026 0.0354419522857733 0.0299816030866586 0 0 0 0 K07173 0.0114285714285714 0.1623931623931624 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] path:map00270,path:map01100,path:map01230,path:map02024,path:map02026,path:map05111 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids,Quorum sensing,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 125.0 43.0 30.0 4.0 0.704918032786885 H 4.0 57.0 2.0 0.934426229508197 COG1854 S-ribosylhomocysteine_lyase_LuxS,_autoinducer_biosynthesis LuxS 61.0 0.0655737704918032 0.9344262295081968 0.009502248591496 0.0539328955150534 0.0317175720532747 0.0444306469235574 0 0 0 0 K07175 0.02 0.3247863247863248 phoH2; PhoH-like ATPase 264.0 126.0 122.0 2.0 0.969230769230769 T 7.0 123.0 2.0 0.969230769230769 COG1875 Predicted_ribonuclease_YlaK,_contains_NYN-type_RNase_and_PhoH-family_ATPase_domains YlaK 130.0 0.0538461538461538 0.946153846153846 0.0151339229965746 0.117655367679227 0.0663946453379008 0.1025214446826524 0 0 0 0 K07176 0.2857142857142857 0.0142450142450142 K07176; putative serine/threonine protein kinase 122.0 107.0 0.0 1.0 1.0 T 102.0 5.0 1.0 1.0 COG2112 Predicted_Ser/Thr_protein_kinase 107.0 0.9532710280373832 0.0467289719626168 0.0049818540782383 0.0064956704867682 0.0057387622825032 0.0015138164085298 0 0 0 0 K07177 0.0 0.1339031339031339 K07177; Lon-like protease 210.0 49.0 48.0 2.0 0.98 T 0.0 50.0 1.0 1.0 COG3480 Predicted_secreted_protein_YlbL,_contains_PDZ_domain SdrC 50.0 0.0 1.0 0.0009596504982623 0.003639322964059 0.0022994867311606 0.0026796724657967 0 0 0 0 K07178 0.8057142857142857 0.0683760683760683 RIOK1; RIO kinase 1 [EC:2.7.11.1] path:map03008 Ribosome biogenesis in eukaryotes 118.0 289.0 253.0 3.0 0.886503067484663 T 302.0 24.0 3.0 0.993865030674847 COG1718 Serine/threonine-protein_kinase_RIO1 RIO1 326.0 0.9263803680981596 0.0736196319018405 0.711216760396618 0.810452589268772 0.760834674832695 0.0992358288721539 0 1 0 1 K07179 0.4114285714285714 0.0 RIOK2; RIO kinase 2 [EC:2.7.11.1] path:map03008 Ribosome biogenesis in eukaryotes 195.0 146.0 0.0 1.0 1.0 T 146.0 0.0 1.0 1.0 COG0478 RIO-like_serine/threonine_protein_kinase_fused_to_N-terminal_HTH_domain RIO2 146.0 1.0 0.0 0.0061168331172845 0.006832121411783 0.0064744772645337 0.0007152882944984 0 0 0 0 K07180 0.1057142857142857 0.1623931623931624 prkA; serine protein kinase 553.0 98.0 0.0 1.0 1.0 T 38.0 60.0 2.0 0.989795918367347 COG2766 Predicted_Ser/Thr_protein_kinase PrkA 98.0 0.3877551020408163 0.6122448979591837 0.0007627266982521 0.0248932288481635 0.0128279777732078 0.0241305021499114 0 0 0 0 K07181 0.0 0.0056980056980056 cdgJ; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 403.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG3434 c-di-GMP_phosphodiesterase_YuxH/PdeH,_contains_EAL_and_HDOD_domains YuxH 3.0 0.0 1.0 0 0 0 0 K07182 0.1942857142857142 0.282051282051282 K07182; CBS domain-containing protein 38.0 116.0 19.0 6.0 0.483333333333333 T 86.0 148.0 4.0 0.5125 COG0517 CBS_domain CBS 234.0 0.3675213675213675 0.6324786324786325 0.0720021198019134 0.157583462767416 0.1147927912846647 0.0855813429655026 0 0 0 0 K07183 0.0 0.0911680911680911 nasT; two-component system, response regulator / RNA-binding antiterminator 151.0 31.0 28.0 2.0 0.911764705882353 T 0.0 34.0 2.0 0.970588235294118 COG3707 Two-component_response_regulator,_AmiR/NasT_family,_consists_of_REC_and_RNA-binding_antiterminator_(ANTAR)_domains AmiR 34.0 0.0 1.0 0.0428831558005335 0.0043496244549117 0.0236163901277226 0.0385335313456218 0 0 0 0 K07184 0.0028571428571428 0.1139601139601139 ygiM; SH3 domain protein 22.0 34.0 25.0 4.0 0.723404255319149 T 1.0 48.0 6.0 0.693877551020408 COG3103 Uncharacterized_conserved_protein_YgiM,_contains_N-terminal_SH3_domain,_DUF1202_family YgiM 49.0 0.0204081632653061 0.979591836734694 0.0019125742652344 0.0043754864945856 0.00314403037991 0.0024629122293512 0 0 0 0 K07186 0.0 0.017094017094017 smp; membrane protein 184.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG3726 Uncharacterized_membrane_protein_Smp_affecting_hemolysin_expression AhpA 6.0 0.0 1.0 1.35196338765171e-12 1.86947832543871e-08 9.348067608887376e-09 1.8693431290999452e-08 0 0 0 0 K07190 0.0114285714285714 0.037037037037037 PHKA_B; phosphorylase kinase alpha/beta subunit path:map04020,path:map04910,path:map04922 Calcium signaling pathway,Insulin signaling pathway,Glucagon signaling pathway 254.0 18.0 0.0 1.0 1.0 G 4.0 14.0 1.0 1.0 COG3387 Glucoamylase_(glucan-1,4-alpha-glucosidase),_GH15_family SGA1 18.0 0.2222222222222222 0.7777777777777778 0.037174538664834 0.226903560804405 0.1320390497346195 0.189729022139571 0 0 0 0 K07192 0.0314285714285714 0.1823361823361823 FLOT; flotillin path:map04910 Insulin signaling pathway 217.0 77.0 67.0 4.0 0.855555555555556 S 11.0 79.0 3.0 0.966666666666667 COG2268 Uncharacterized_membrane_protein_YqiK,_contains_Band7/PHB/SPFH_domain YqiK 90.0 0.1222222222222222 0.8777777777777778 0.0174696638658822 0.7170291507472 0.3672494073065411 0.6995594868813177 0 0 0 0 K07208 0.0057142857142857 0.0 RHEB; Ras homolog enriched in brain path:map04072,path:map04140,path:map04150,path:map04151,path:map04152,path:map04211,path:map04218,path:map04714,path:map04910,path:map04919,path:map05163,path:map05165,path:map05168,path:map05231 Phospholipase D signaling pathway,Autophagy - animal,mTOR signaling pathway,PI3K-Akt signaling pathway,AMPK signaling pathway,Longevity regulating pathway,Cellular senescence,Thermogenesis,Insulin signaling pathway,Thyroid hormone signaling pathway,Human cytomegalovirus infection,Human papillomavirus infection,Herpes simplex virus 1 infection,Choline metabolism in cancer 91.0 1.0 0.0 2.0 0.5 G 2.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 2.0 1.0 0.0 0 0 0 0 K07212 0.0 0.0056980056980056 329.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 2.0 0.0 1.0 0 0 0 0 K07213 0.2142857142857142 0.3333333333333333 ATOX1, ATX1, copZ, golB; copper chaperone path:map04978 Mineral absorption 37.0 182.0 155.0 3.0 0.781115879828326 P 81.0 152.0 5.0 0.738197424892704 COG2608 Copper_chaperone_CopZ CopZ 233.0 0.3476394849785407 0.6523605150214592 0.0123120141639897 0.434646956088557 0.2234794851262733 0.4223349419245673 0 0 0 0 K07214 0.0257142857142857 0.1937321937321937 fes; iron(III)-enterobactin esterase [EC:3.1.1.108] 46.0 90.0 82.0 8.0 0.731707317073171 P 10.0 113.0 9.0 0.747967479674797 COG2382 Enterochelin_esterase_or_related_enzyme Fes 123.0 0.08130081300813 0.91869918699187 0.0021170306306877 0.011613952031028 0.0068654913308578 0.0094969214003403 0 0 0 0 K07215 0.0 0.0284900284900284 pigA, hemO; heme oxygenase (biliverdin-IX-beta and delta-forming) [EC:1.14.99.58] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 172.0 8.0 0.0 1.0 1.0 P 0.0 10.0 1.0 1.0 COG3230 Heme_oxygenase HemO 10.0 0.0 1.0 0.0586588716994182 0.102883951602828 0.0807714116511231 0.0442250799034098 0 0 0 0 K07216 0.06 0.1937321937321937 hr; hemerythrin 21.0 125.0 101.0 7.0 0.76219512195122 P 24.0 138.0 8.0 0.75 COG2703 Hemerythrin 162.0 0.1481481481481481 0.8518518518518519 0.0304666567484023 0.0807686801453863 0.0556176684468942 0.0503020233969839 0 0 0 0 K07217 0.0514285714285714 0.0769230769230769 K07217; Mn-containing catalase 182.0 53.0 0.0 1.0 1.0 P 20.0 33.0 1.0 1.0 COG3546 Mn-containing_catalase_(includes_spore_coat_protein_CotJC) CotJC 53.0 0.3773584905660377 0.6226415094339622 0.0574631918348914 0.0952374106889723 0.0763503012619318 0.0377742188540809 0 0 0 0 K07218 0.0714285714285714 0.1082621082621082 nosD; nitrous oxidase accessory protein 196.0 76.0 73.0 2.0 0.962025316455696 P 36.0 41.0 2.0 0.911392405063291 COG3420 Nitrous_oxide_reductase_accessory_protein_NosD,_contains_tandem_CASH_domains NosD 77.0 0.4675324675324675 0.5324675324675324 0.0836910921078862 0.142357177094748 0.113024134601317 0.0586660849868617 0 0 0 0 K07219 0.4714285714285714 0.1709401709401709 K07219; putative molybdopterin biosynthesis protein 241.0 191.0 145.0 4.0 0.6996336996337 H 207.0 63.0 6.0 0.860805860805861 COG0303 Molybdopterin_Mo-transferase_(molybdopterin_biosynthesis) MoeA 270.0 0.7666666666666667 0.2333333333333333 0.948269940586572 0.977924535101366 0.9630972378439692 0.029654594514794 1 1 1 1 K07220 0.4742857142857143 0.3447293447293447 K07220; uncharacterized protein 45.0 315.0 240.0 2.0 0.807692307692308 P 250.0 140.0 3.0 0.982051282051282 COG1392 Phosphate_transport_regulator_YkaA,_distantly_related_to_PhoU,_UPF0111/DUF47_family YkaA 390.0 0.6410256410256411 0.358974358974359 0.109691697642221 0.912307565362215 0.510999631502218 0.802615867719994 0 0 0 0 K07221 0.0 0.0826210826210826 oprO_P; phosphate-selective porin OprO and OprP 142.0 27.0 24.0 3.0 0.870967741935484 P 0.0 37.0 3.0 0.891891891891892 COG3746 Phosphate-selective_porin OprP 37.0 0.0 1.0 0.0131584040885716 0.036201965520447 0.0246801848045093 0.0230435614318754 0 0 0 0 K07222 0.0028571428571428 0.1367521367521367 K07222; putative flavoprotein involved in K+ transport 191.0 61.0 54.0 2.0 0.897058823529412 P 1.0 67.0 2.0 0.985294117647059 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 68.0 0.0147058823529411 0.9852941176470588 0.0156499884147205 0.136552767685604 0.0761013780501622 0.1209027792708835 0 0 0 0 K07223 0.0028571428571428 0.0826210826210826 yfeX; porphyrinogen peroxidase [EC:1.11.1.-] 222.0 33.0 32.0 2.0 0.970588235294117 P 1.0 33.0 2.0 0.970588235294118 COG2837 Periplasmic_deferrochelatase/peroxidase_EfeB EfeB 34.0 0.0294117647058823 0.9705882352941176 0.0232363705688774 0.299355916914234 0.1612961437415557 0.2761195463453566 0 0 0 0 K07224 0.0 0.0626780626780626 efeO; iron uptake system component EfeO 225.0 26.0 0.0 1.0 1.0 P 0.0 27.0 2.0 0.962962962962963 COG2822 Iron_uptake_system_EfeUOB,_periplasmic_(or_lipoprotein)_component_EfeO/EfeM EfeO 27.0 0.0 1.0 0.0074199605073388 0.0361900260658017 0.0218049932865702 0.0287700655584629 0 0 0 0 K07225 0.0 0.0826210826210826 hmuS; putative hemin transport protein 278.0 30.0 0.0 1.0 1.0 P 0.0 30.0 2.0 0.966666666666667 COG3720 Putative_heme_degradation_protein HemS 30.0 0.0 1.0 0.0078198722552392 0.0326912119526206 0.0202555421039299 0.0248713396973814 0 0 0 0 K07226 0.0028571428571428 0.1168091168091168 hutZ, hugZ; heme oxygenase (biliverdin-IX-beta and delta-forming) [EC:1.14.99.58] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 118.0 45.0 0.0 1.0 1.0 P 1.0 43.0 1.0 1.0 COG0748 Putative_heme_iron_utilization_protein,_contains_PNPOx_domain HugZ 44.0 0.0227272727272727 0.9772727272727272 0.0105945679680974 0.0675705611290162 0.0390825645485568 0.0569759931609188 0 0 0 0 K07227 0.0028571428571428 0.017094017094017 chuX; heme iron utilization protein 162.0 8.0 0.0 1.0 1.0 P 1.0 7.0 1.0 1.0 COG3721 Putative_heme_iron_utilization_protein HugX 8.0 0.125 0.875 0.0391101730820659 0.122004025253584 0.0805570991678249 0.0828938521715181 0 0 0 0 K07228 0.1085714285714285 0.074074074074074 K07228; TrkA domain protein 135.0 70.0 0.0 1.0 1.0 P 41.0 29.0 1.0 1.0 COG0490 K+/H+_antiporter_KhtSTU,_c-di-AMP-binding_regulatory_subunit_KhtT,_contains_RCK_C_(TrkA_C)_domain KhtT 70.0 0.5857142857142857 0.4142857142857143 0.0270270692732042 0.093080988188511 0.0600540287308576 0.0660539189153068 0 0 0 0 K07229 0.0 0.0028490028490028 yqjH; ferric-chelate reductase (NADPH) [EC:1.16.1.9] 254.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG2375 NADPH-dependent_ferric_siderophore_reductase,_contains_FAD-binding_and_SIP_domains ViuB 1.0 0.0 1.0 0 0 0 0 K07230 0.0 0.0398860398860398 p19, ftrA; periplasmic iron binding protein 170.0 16.0 0.0 1.0 1.0 P 0.0 16.0 1.0 1.0 COG3470 Uncharacterized_conserved_protein_probably_involved_in_high-affinity_Fe2+_transport Tpd 16.0 0.0 1.0 0.041410890498568 0.135501454236344 0.088456172367456 0.094090563737776 0 0 0 0 K07231 0.0 0.0598290598290598 K07231; putative iron-regulated protein 370.0 21.0 20.0 2.0 0.954545454545455 P 0.0 22.0 1.0 1.0 COG3487 Imelysin-like_iron-regulated_protein_IrpA,_duplicated_M75_peptidase-like_domain IrpA 22.0 0.0 1.0 0.0122479104581911 0.0347180427756517 0.0234829766169214 0.0224701323174606 0 0 0 0 K07232 0.0 0.0911680911680911 CHAC, chaC; glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 139.0 45.0 0.0 1.0 1.0 P 0.0 45.0 1.0 1.0 COG3703 Gamma-glutamylcyclotransferase_ChaC2_(glutathione_degradation) ChaC2 45.0 0.0 1.0 0.0074381489360109 0.0155999719069915 0.0115190604215012 0.0081618229709806 0 0 0 0 K07233 0.0 0.0712250712250712 pcoB, copB; copper resistance protein B 160.0 27.0 21.0 3.0 0.75 P 0.0 36.0 3.0 0.75 COG3667 Uncharacterized_conserved_protein_involved_in_copper_resistance PcoB 36.0 0.0 1.0 0.0191556850757872 0.114111379543132 0.0666335323094595 0.0949556944673448 0 0 0 0 K07234 0.02 0.1481481481481481 K07234; uncharacterized protein involved in response to NO 204.0 46.0 39.0 3.0 0.807017543859649 P 8.0 60.0 5.0 0.676470588235294 COG3213 Nitric_oxide_response_protein_NnrS NnrS 68.0 0.1176470588235294 0.8823529411764706 0.022813812505972 0.162340051346888 0.09257693192643 0.139526238840916 0 0 0 0 K07235 0.1485714285714285 0.0997150997150997 tusD, dsrE; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-] path:map04122 Sulfur relay system 68.0 101.0 99.0 2.0 0.980582524271845 P 64.0 39.0 1.0 1.0 COG1553 Sulfur_relay_(sulfurtransferase)_complex_TusBCD_TusD_component,_DsrE_family DsrE 103.0 0.6213592233009708 0.3786407766990291 0.956853886661478 0.692287643421942 0.82457076504171 0.2645662432395359 1 1 1 1 K07236 0.0828571428571428 0.0854700854700854 tusC, dsrF; tRNA 2-thiouridine synthesizing protein C path:map04122 Sulfur relay system 60.0 63.0 62.0 2.0 0.984375 P 33.0 31.0 2.0 0.921875 COG2923 Sulfur_transfer_complex_TusBCD_TusC_component,_DsrF_family DsrF 64.0 0.515625 0.484375 0.965955556884502 0.924664418726917 0.9453099878057094 0.041291138157585 1 1 1 1 K07237 0.0371428571428571 0.0712250712250712 tusB, dsrH; tRNA 2-thiouridine synthesizing protein B path:map04122 Sulfur relay system 49.0 23.0 12.0 3.0 0.638888888888889 P 13.0 26.0 3.0 0.641025641025641 COG2168 Sulfur_transfer_complex_TusBCD_TusB_component,_DsrH_family TusB 39.0 0.3333333333333333 0.6666666666666666 0.982713023718378 0.445998049491657 0.7143555366050175 0.536714974226721 1 1 1 1 K07238 0.46 0.4558404558404558 TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family 128.0 457.0 456.0 2.0 0.997816593886463 P 260.0 198.0 1.0 1.0 COG0428 Zinc_transporter_ZupT ZupT 458.0 0.5676855895196506 0.4323144104803493 0.884833135323037 0.764717974486873 0.8247755549049549 0.120115160836164 1 1 1 1 K07239 0.0 0.0398860398860398 TC.HME; heavy-metal exporter, HME family 1011.0 23.0 0.0 1.0 1.0 P 0.0 23.0 1.0 1.0 COG3696 Cu/Ag_efflux_pump_CusA CusA 23.0 0.0 1.0 0.0147898320527038 0.0353100324593577 0.0250499322560307 0.0205202004066539 0 0 0 0 K07240 0.02 0.4444444444444444 chrA; chromate transporter 85.0 305.0 0.0 1.0 1.0 P 9.0 294.0 1.0 1.0 COG2059 Chromate_transport_protein_ChrA ChrA 303.0 0.0297029702970297 0.9702970297029704 0.0388240908595909 0.515319433002022 0.2770717619308064 0.4764953421424311 0 0 0 0 K07241 0.0514285714285714 0.0797720797720797 hoxN, nixA; nickel/cobalt transporter (NiCoT) family protein 192.0 23.0 2.0 5.0 0.433962264150943 P 21.0 32.0 3.0 0.528301886792453 COG2042 Ribosome_biogenesis_protein_Tsr3_(rRNA_maturation) Tsr3 53.0 0.3962264150943396 0.6037735849056604 0.046319139399652 0.669481309738711 0.3579002245691815 0.623162170339059 0 0 0 0 K07242 0.0 0.0341880341880341 K07242; putative multicomponent Na+:H+ antiporter subunit B 186.0 10.0 9.0 3.0 0.833333333333333 P 0.0 12.0 2.0 0.916666666666667 COG1563 Uncharacterized_MnhB-related_membrane_protein 12.0 0.0 1.0 0.0216760718667754 0.0272897680492049 0.0244829199579901 0.0056136961824295 0 0 0 0 K07243 0.1257142857142857 0.2051282051282051 FTR, FTH1, efeU; high-affinity iron transporter 161.0 124.0 114.0 2.0 0.925373134328358 P 46.0 86.0 3.0 0.955223880597015 COG0672 High-affinity_Fe2+/Pb2+_permease FTR1 132.0 0.3484848484848485 0.6515151515151515 0.78932852449347 0.929840351421107 0.8595844379572886 0.1405118269276369 1 1 1 1 K07244 0.3771428571428571 0.0 K07244; mgtE-like transporter 117.0 200.0 0.0 1.0 1.0 P 200.0 0.0 2.0 0.97 COG1824 Permease,_similar_to_cation_transporters MgtE2 200.0 1.0 0.0 0.381513140867112 0.707720531455125 0.5446168361611186 0.326207390588013 0 0 0 0 K07245 0.0457142857142857 0.150997150997151 pcoD; copper resistance protein D 85.0 73.0 65.0 5.0 0.793478260869565 P 17.0 70.0 9.0 0.494623655913979 COG1276 Putative_copper_export_protein PcoD 87.0 0.1954022988505747 0.8045977011494253 0.237359908566555 0.920269393524509 0.578814651045532 0.682909484957954 0 0 0 0 K07246 0.0514285714285714 0.131054131054131 ttuC, dmlA; tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.93 4.1.1.73 1.1.1.83] path:map00630,path:map00650,path:map01100 Glyoxylate and dicarboxylate metabolism,Butanoate metabolism,Metabolic pathways 311.0 43.0 6.0 3.0 0.524390243902439 CE 22.0 60.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 82.0 0.2682926829268293 0.7317073170731707 0.179625977471442 0.465228356960755 0.3224271672160985 0.285602379489313 0 0 0 0 K07248 0.0028571428571428 0.0455840455840455 aldA; lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21] path:map00620,path:map00630,path:map01100,path:map01120 Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 466.0 18.0 0.0 1.0 1.0 C 1.0 17.0 2.0 0.944444444444444 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 18.0 0.0555555555555555 0.9444444444444444 0.0527813895124386 0.104588661081613 0.0786850252970258 0.0518072715691743 0 0 0 0 K07250 0.2228571428571428 0.2165242165242165 gabT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] path:map00250,path:map00280,path:map00310,path:map00410,path:map00640,path:map00650,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 288.0 161.0 130.0 3.0 0.800995024875622 E 109.0 92.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 201.0 0.5422885572139303 0.4577114427860697 0.790134781500129 0.987835226966693 0.888985004233411 0.197700445466564 1 1 1 1 K07251 0.0028571428571428 0.0569800569800569 thiK; thiamine kinase [EC:2.7.1.89] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 88.0 23.0 22.0 3.0 0.92 M 1.0 24.0 1.0 1.0 COG0510 Thiamine_kinase_or_a_related_kinase CotS 25.0 0.04 0.96 0.0324199650358325 0.194909967103946 0.1136649660698892 0.1624900020681135 0 0 0 0 K07254 0.7 0.0 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206] 138.0 253.0 0.0 1.0 1.0 J 252.0 0.0 1.0 1.0 COG1303 tRNA_C56-2-O'-methylase,_SpoU_family TRM56 252.0 1.0 0.0 0.0842801639680198 0.10054384430538 0.0924120041366999 0.0162636803373602 0 0 0 0 K07255 0.0 0.0085470085470085 tauX; taurine dehydrogenase small subunit [EC:1.4.2.-] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 70.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 COG3631 Ketosteroid_isomerase-related_protein YesE 3.0 0.0 1.0 0 0 0 0 K07256 0.0 0.0085470085470085 tauY; taurine dehydrogenase large subunit [EC:1.4.2.-] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 453.0 2.0 1.0 2.0 0.666666666666667 E 0.0 3.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 3.0 0.0 1.0 0 0 0 0 K07257 0.06 0.1424501424501424 spsF; spore coat polysaccharide biosynthesis protein SpsF 116.0 67.0 54.0 4.0 0.770114942528736 M 26.0 60.0 6.0 0.67816091954023 COG1861 Spore_coat_polysaccharide_biosynthesis_protein_SpsF,_cytidylyltransferase_family SpsF 86.0 0.3023255813953488 0.6976744186046512 0.489336463557724 0.565334244007811 0.5273353537827674 0.0759977804500869 0 0 0 0 K07258 0.0028571428571428 0.5698005698005698 dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 77.0 320.0 314.0 5.0 0.96969696969697 M 1.0 329.0 7.0 0.963636363636364 COG1686 D-alanyl-D-alanine_carboxypeptidase DacC 330.0 0.003030303030303 0.996969696969697 0.0014245852613755 0.668414138194545 0.3349193617279602 0.6669895529331695 0 0 0 0 K07259 0.0171428571428571 0.4017094017094017 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 123.0 197.0 0.0 1.0 1.0 M 6.0 191.0 1.0 1.0 COG2027 D-alanyl-D-alanine_carboxypeptidase DacB 197.0 0.0304568527918781 0.9695431472081218 0.144420941441876 0.162646174579254 0.153533558010565 0.018225233137378 0 0 0 0 K07260 0.0228571428571428 0.2364672364672364 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] path:map00550,path:map01100,path:map01502,path:map02020 Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance,Two-component system 22.0 96.0 78.0 6.0 0.755905511811024 M 8.0 119.0 12.0 0.68503937007874 COG1876 LD-carboxypeptidase_LdcB,_LAS_superfamily LdcB 127.0 0.0629921259842519 0.937007874015748 0.0119381720281373 0.618086990262918 0.3150125811455276 0.6061488182347807 0 0 0 0 K07261 0.0028571428571428 0.0797720797720797 mepA; penicillin-insensitive murein DD-endopeptidase [EC:3.4.24.-] 151.0 33.0 0.0 1.0 1.0 M 1.0 32.0 4.0 0.757575757575758 COG3770 Murein_endopeptidase_MepA_(D-alanyl-D-alanine-endopeptidase) MepA 33.0 0.0303030303030303 0.9696969696969696 0.0124660689639226 0.0261332370173774 0.01929965299065 0.0136671680534548 0 0 0 0 K07262 0.0 0.0883190883190883 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-] 211.0 32.0 0.0 1.0 1.0 M 0.0 32.0 1.0 1.0 COG1686 D-alanyl-D-alanine_carboxypeptidase DacC 32.0 0.0 1.0 0.0076256603096484 0.249479543942826 0.1285526021262372 0.2418538836331776 0 0 0 0 K07263 0.0171428571428571 0.5014245014245015 pqqL; zinc protease [EC:3.4.24.-] 62.0 364.0 336.0 5.0 0.894348894348894 S 10.0 395.0 2.0 0.977886977886978 COG0612 Predicted_Zn-dependent_peptidase,_M16_family PqqL 405.0 0.0246913580246913 0.9753086419753086 0.0038151448147661 0.0103417358608715 0.0070784403378188 0.0065265910461054 0 0 0 0 K07264 0.0057142857142857 0.0569800569800569 arnT, pmrK; 4-amino-4-deoxy-L-arabinose transferase [EC:2.4.2.43] path:map00540,path:map01503 Lipopolysaccharide biosynthesis,Cationic antimicrobial peptide (CAMP) resistance 294.0 21.0 19.0 2.0 0.91304347826087 M 2.0 21.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 23.0 0.0869565217391304 0.9130434782608696 0.382537169668574 0.90896001034309 0.645748590005832 0.5264228406745161 0 0 0 0 K07265 0.0 0.0598290598290598 kpsS, lipB; capsular polysaccharide export protein 314.0 23.0 0.0 1.0 1.0 M 0.0 23.0 1.0 1.0 COG3562 Capsule_polysaccharide_modification_protein_KpsS KpsS 23.0 0.0 1.0 0.0397766686034343 0.0794950800892053 0.0596358743463198 0.039718411485771 0 0 0 0 K07266 0.0 0.0541310541310541 kpsC, lipA; capsular polysaccharide export protein 276.0 22.0 0.0 1.0 1.0 M 0.0 23.0 3.0 0.91304347826087 COG3563 Capsule_polysaccharide_export_protein_KpsC/LpsZ KpsC 23.0 0.0 1.0 0.0095402141506916 0.0178953044034445 0.013717759277068 0.0083550902527529 0 0 0 0 K07267 0.0 0.0883190883190883 oprB; porin 69.0 41.0 39.0 2.0 0.953488372093023 M 0.0 43.0 2.0 0.813953488372093 COG3659 Carbohydrate-selective_porin_OprB OprB 43.0 0.0 1.0 0.039347462018544 0.0295516124845543 0.0344495372515491 0.0097958495339896 0 0 0 0 K07268 0.0085714285714285 0.0199430199430199 oapA; opacity associated protein 126.0 6.0 2.0 2.0 0.6 GM 3.0 7.0 5.0 0.4 COG3061 Cell_division_protein_YtfB/OapA_(opacity-associated_protein_A) OapA 10.0 0.3 0.7 0.0355655624657521 0.0677954381350524 0.0516805003004022 0.0322298756693003 0 0 0 0 K07269 0.0 0.0113960113960113 ytfB; cell division protein YtfB 136.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3061 Cell_division_protein_YtfB/OapA_(opacity-associated_protein_A) OapA 4.0 0.0 1.0 3.23091359505026e-12 2.71115467673418e-08 1.3557388840468424e-08 2.7108315853746754e-08 0 0 0 0 K07270 0.0 0.074074074074074 K07270; glycosyl transferase, family 25 74.0 29.0 27.0 2.0 0.935483870967742 M 0.0 31.0 2.0 0.967741935483871 COG3306 Glycosyltransferase_involved_in_LPS_biosynthesis,_GR25_family 31.0 0.0 1.0 0.0191281968408471 0.0377668756460182 0.0284475362434326 0.0186386788051711 0 0 0 0 K07271 0.0114285714285714 0.0512820512820512 licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-] path:map00552 Teichoic acid biosynthesis 87.0 32.0 0.0 1.0 1.0 M 7.0 25.0 2.0 0.96875 COG3475 Phosphorylcholine_metabolism_protein_LicD LicD 32.0 0.21875 0.78125 0.0120185121790717 0.0262242294955814 0.0191213708373265 0.0142057173165097 0 0 0 0 K07272 0.0 0.0341880341880341 rgpF; rhamnosyltransferase [EC:2.4.1.-] 140.0 9.0 0.0 1.0 1.0 M 0.0 12.0 3.0 0.666666666666667 COG3754 Lipopolysaccharide_biosynthesis_protein RgpF 12.0 0.0 1.0 0.104933937460049 0.201563981324758 0.1532489593924035 0.096630043864709 0 0 0 0 K07273 0.0057142857142857 0.1253561253561253 acm; lysozyme 54.0 52.0 50.0 3.0 0.928571428571429 M 2.0 54.0 8.0 0.696428571428571 COG3757 Lyzozyme_M1_(1,4-beta-N-acetylmuramidase),_GH25_family Acm 56.0 0.0357142857142857 0.9642857142857144 0.0364320420154233 0.108879597865108 0.0726558199402656 0.0724475558496847 0 0 0 0 K07274 0.0 0.0797720797720797 mipA, ompV; MipA family protein 62.0 34.0 0.0 1.0 1.0 M 0.0 38.0 2.0 0.894736842105263 COG3713 Outer_membrane_scaffolding_protein_for_murein_synthesis,_MipA/OmpV_family OmpV 38.0 0.0 1.0 0.013875104730937 0.0713684756695238 0.0426217902002304 0.0574933709385868 0 0 0 0 K07275 0.0 0.150997150997151 ompW; outer membrane protein 76.0 54.0 0.0 1.0 1.0 M 0.0 71.0 4.0 0.873239436619718 COG3047 Outer_membrane_protein_OmpW OmpW 71.0 0.0 1.0 0.0040692583676497 0.0052618000877493 0.0046655292276995 0.0011925417200995 0 0 0 0 K07276 0.0 0.1168091168091168 K07276; uncharacterized protein 119.0 36.0 29.0 2.0 0.837209302325581 M 0.0 43.0 2.0 0.837209302325581 COG3660 Mitochondrial_fission_protein_ELM1 ELM1 43.0 0.0 1.0 0.96626829845399 0.12666913100819 0.54646871473109 0.8395991674458 0 0 1 1 K07277 0.0 0.6410256410256411 SAM50, TOB55, bamA; outer membrane protein insertion porin family 21.0 333.0 312.0 6.0 0.912328767123288 M 0.0 359.0 12.0 0.819178082191781 COG4775 Outer_membrane_protein_assembly_factor_BamA BamA 359.0 0.0 1.0 0.0081299465536022 0.0474365291079669 0.0277832378307845 0.0393065825543647 0 0 0 0 K07278 0.0 0.1965811965811965 tamA; translocation and assembly module TamA 206.0 70.0 0.0 1.0 1.0 M 0.0 70.0 2.0 0.957142857142857 COG0729 Outer_membrane_translocation_and_assembly_module_TamA TamA 70.0 0.0 1.0 0.0070662227046462 0.0134252291222895 0.0102457259134678 0.0063590064176433 0 0 0 0 K07279 0.0 0.0113960113960113 yfaL; autotransporter family porin 279.0 4.0 3.0 2.0 0.8 S 0.0 5.0 2.0 0.8 COG4447 Uncharacterized_conserved_protein_related_to_plant_photosystem_II_stability/assembly_factor 5.0 0.0 1.0 0.0144152961146849 1.24271839302844e-08 0.0072076542709344 0.0144152836875009 0 0 0 0 K07280 0.0 0.0028490028490028 K07280; outer membrane protein 1561.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K07281 0.14 0.0455840455840455 ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 128.0 32.0 4.0 4.0 0.450704225352113 M 52.0 17.0 3.0 0.71830985915493 COG1213 Choline_kinase 69.0 0.7536231884057971 0.2463768115942029 0.774663129452753 0.964572754311862 0.8696179418823075 0.189909624859109 1 1 1 1 K07282 0.1257142857142857 0.3618233618233618 capA, pgsA; gamma-polyglutamate biosynthesis protein CapA 28.0 227.0 223.0 4.0 0.97008547008547 M 53.0 179.0 6.0 0.94017094017094 COG2843 Poly-gamma-glutamate_biosynthesis_protein_CapA/YwtB_(capsule_formation),_metallophosphatase_superfamily CapA 232.0 0.2284482758620689 0.771551724137931 0.0781819487456589 0.887267979004955 0.4827249638753069 0.8090860302592962 0 0 0 0 K07283 0.0 0.0968660968660968 ydiY; putative salt-induced outer membrane protein 87.0 25.0 0.0 1.0 1.0 M 0.0 38.0 1.0 1.0 COG3137 Putative_salt-induced_outer_membrane_protein_YdiY YdiY 38.0 0.0 1.0 0.0184846601793923 0.0366500420191415 0.0275673510992669 0.0181653818397492 0 0 0 0 K07284 0.0085714285714285 0.2222222222222222 srtA; sortase A [EC:3.4.22.70] 58.0 132.0 0.0 1.0 1.0 M 4.0 128.0 2.0 0.992424242424242 COG3764 Sortase_(surface_protein_transpeptidase) SrtA 132.0 0.0303030303030303 0.9696969696969696 0.0009770362912585 0.919859463706919 0.4604182499990887 0.9188824274156604 0 0 0 0 K07285 0.0 0.0626780626780626 slp; outer membrane lipoprotein 82.0 34.0 0.0 1.0 1.0 M 0.0 34.0 1.0 1.0 COG3065 Starvation-inducible_outer_membrane_lipoprotein_Slp Slp 34.0 0.0 1.0 0.0104232971953612 0.0071143014628018 0.0087687993290814 0.0033089957325593 0 0 0 0 K07286 0.0 0.0256410256410256 yajG; uncharacterized lipoprotein 178.0 9.0 0.0 1.0 1.0 M 0.0 9.0 1.0 1.0 COG3056 Uncharacterized_lipoprotein_YajG YajG 9.0 0.0 1.0 2.2119120179657e-06 7.79251062957954e-08 1.1449185621307476e-06 2.1339869116699047e-06 0 0 0 0 K07287 0.0 0.0797720797720797 bamC; outer membrane protein assembly factor BamC 162.0 29.0 0.0 1.0 1.0 M 0.0 29.0 2.0 0.896551724137931 COG3317 Outer_membrane_beta-barrel_protein_assembly_factor_BamC BamC 29.0 0.0 1.0 0.0038425489599001 0.0088408385816118 0.0063416937707559 0.0049982896217117 0 0 0 0 K07288 0.0 0.0199430199430199 tspA; uncharacterized membrane protein 210.0 4.0 2.0 3.0 0.571428571428571 KT 0.0 7.0 3.0 0.571428571428571 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 7.0 0.0 1.0 2.3751281631577297e-12 0.0178390195427631 0.0089195097725691 0.0178390195403879 0 0 0 0 K07289 0.0 0.2022792022792023 asmA; AsmA protein 130.0 85.0 84.0 2.0 0.988372093023256 M 0.0 86.0 3.0 0.976744186046512 COG2982 Uncharacterized_conserved_protein_AsmA_involved_in_outer_membrane_biogenesis AsmA 86.0 0.0 1.0 0.0031708137264487 0.0624022567878111 0.0327865352571299 0.0592314430613623 0 0 0 0 K07290 0.0 0.0484330484330484 yhjG; AsmA family protein 449.0 23.0 0.0 1.0 1.0 M 0.0 23.0 1.0 1.0 COG2982 Uncharacterized_conserved_protein_AsmA_involved_in_outer_membrane_biogenesis AsmA 23.0 0.0 1.0 0.0102656020181753 0.0199671786155963 0.0151163903168858 0.009701576597421 0 0 0 0 K07291 0.14 0.0313390313390313 dipps; CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.8.34] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 116.0 52.0 38.0 3.0 0.693333333333333 I 57.0 12.0 2.0 0.573333333333333 COG0558 Phosphatidylglycerophosphate_synthase PgsA 69.0 0.8260869565217391 0.1739130434782608 0.65220265998716 0.520754971623419 0.5864788158052895 0.131447688363741 0 1 0 1 K07300 0.0457142857142857 0.1566951566951566 chaA, CAX; Ca2+:H+ antiporter 291.0 84.0 0.0 1.0 1.0 P 16.0 68.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 84.0 0.1904761904761904 0.8095238095238095 0.0710140089890135 0.73256836136469 0.4017911851768517 0.6615543523756764 0 0 0 0 K07301 0.6542857142857142 0.5270655270655271 yrbG; cation:H+ antiporter 97.0 616.0 0.0 1.0 1.0 P 361.0 255.0 1.0 1.0 COG0530 Ca2+/Na+_antiporter ECM27 616.0 0.586038961038961 0.413961038961039 0.816784228462974 0.841508878364485 0.8291465534137294 0.0247246499015109 1 1 1 1 K07302 0.0085714285714285 0.2136752136752136 iorA; isoquinoline 1-oxidoreductase subunit alpha [EC:1.3.99.16] 120.0 146.0 145.0 2.0 0.993197278911565 C 3.0 144.0 3.0 0.979591836734694 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 147.0 0.0204081632653061 0.979591836734694 0.148082876973908 0.88475302977525 0.5164179533745791 0.7366701528013421 0 0 0 0 K07303 0.0 0.1623931623931624 iorB; isoquinoline 1-oxidoreductase subunit beta [EC:1.3.99.16] 515.0 118.0 0.0 1.0 1.0 C 0.0 118.0 2.0 0.983050847457627 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 118.0 0.0 1.0 0.0099209264795087 0.0237945421833889 0.0168577343314487 0.0138736157038802 0 0 0 0 K07304 0.4171428571428571 0.6780626780626781 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] 86.0 461.0 414.0 2.0 0.90748031496063 O 171.0 328.0 2.0 0.998031496062992 COG0225 Peptide_methionine_sulfoxide_reductase_MsrA MsrA 499.0 0.342685370741483 0.657314629258517 0.0568589437180823 0.125038315382171 0.0909486295501266 0.0681793716640887 0 0 0 0 K07305 0.3685714285714285 0.5897435897435898 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] 80.0 332.0 263.0 3.0 0.823821339950372 O 137.0 266.0 2.0 0.895781637717122 COG0229 Peptide_methionine_sulfoxide_reductase_MsrB MsrB 403.0 0.3399503722084367 0.6600496277915633 0.0338555363199308 0.0864407356875125 0.0601481360037216 0.0525851993675816 0 0 0 0 K07306 0.0142857142857142 0.0484330484330484 dmsA; anaerobic dimethyl sulfoxide reductase subunit A [EC:1.8.5.3] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 450.0 33.0 0.0 1.0 1.0 C 5.0 28.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 33.0 0.1515151515151515 0.8484848484848485 0.0206580181376398 0.0380538951813568 0.0293559566594983 0.017395877043717 0 0 0 0 K07307 0.0314285714285714 0.0484330484330484 dmsB; anaerobic dimethyl sulfoxide reductase subunit B path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 124.0 44.0 0.0 1.0 1.0 C 17.0 27.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 44.0 0.3863636363636363 0.6136363636363636 0.0129504992945999 0.018573388686564 0.0157619439905819 0.005622889391964 0 0 0 0 K07308 0.0 0.0313390313390313 dmsC; anaerobic dimethyl sulfoxide reductase subunit C path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 241.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG3302 DMSO_reductase_anchor_subunit_DmsC DmsC 17.0 0.0 1.0 0.0041007548188845 0.0089236603438339 0.0065122075813592 0.0048229055249494 0 0 0 0 K07309 0.0 0.0142450142450142 ynfE; Tat-targeted selenate reductase subunit YnfE [EC:1.97.1.9] path:map00450 Selenocompound metabolism 685.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 12.0 0.0 1.0 0.0086861519740188 0.0136314306688729 0.0111587913214458 0.0049452786948541 0 0 0 0 K07310 0.0 0.0142450142450142 ynfF; Tat-targeted selenate reductase subunit YnfF [EC:1.97.1.9] path:map00450 Selenocompound metabolism 692.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 11.0 0.0 1.0 0.010630673175355 0.0174314026678217 0.0140310379215883 0.0068007294924666 0 0 0 0 K07311 0.0 0.0085470085470085 ynfG; Tat-targeted selenate reductase subunit YnfG 203.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 5.0 0.0 1.0 6.1988441650988495e-12 0.0644946724674316 0.0322473362368152 0.0644946724612327 0 0 0 0 K07312 0.0 0.0028490028490028 ynfH; Tat-targeted selenate reductase subunit YnfH 284.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3302 DMSO_reductase_anchor_subunit_DmsC DmsC 2.0 0.0 1.0 0 0 0 0 K07313 0.1 0.2877492877492877 pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16] 79.0 159.0 157.0 2.0 0.987577639751553 T 38.0 123.0 2.0 0.987577639751553 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 161.0 0.2360248447204969 0.7639751552795031 0.0018224122943616 0.0060771065517357 0.0039497594230486 0.0042546942573741 0 0 0 0 K07314 0.0 0.0028490028490028 pphB; serine/threonine protein phosphatase 2 [EC:3.1.3.16] 218.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 1.0 0.0 1.0 0 0 0 0 K07315 0.0 0.0 rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3] 320.0 101.0 10.0 0.578661844484629 T 0.0 0.0 44.0 0.394213381555154 COG2208 Phosphoserine_phosphatase_RsbU,_regulator_of_sigma_subunit RsbU 0.0 0 0 0 0 K07316 0.0 0.0 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 355.0 330.0 4.0 0.929319371727749 L 0.0 0.0 7.0 0.93455497382199 COG2189 Adenine_specific_DNA_methylase_Mod Mod 0.0 0 0 0 0 K07317 0.1457142857142857 0.1424501424501424 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 33.0 66.0 26.0 4.0 0.496240601503759 V 71.0 62.0 6.0 0.496296296296296 COG0827 Adenine-specific_DNA_N6-methylase YtxK 133.0 0.5338345864661654 0.4661654135338345 0.65071855583917 0.755234158990344 0.702976357414757 0.1045156031511739 0 1 0 1 K07318 0.0257142857142857 0.0769230769230769 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 119.0 43.0 37.0 2.0 0.877551020408163 L 13.0 36.0 3.0 0.816326530612245 COG3392 Adenine-specific_DNA_methylase 49.0 0.2653061224489796 0.7346938775510204 0.21339381673505 0.419975702747996 0.316684759741523 0.206581886012946 0 0 0 0 K07319 0.0457142857142857 0.1396011396011396 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 101.0 73.0 69.0 3.0 0.9125 L 17.0 63.0 5.0 0.45 COG2189 Adenine_specific_DNA_methylase_Mod Mod 80.0 0.2125 0.7875 0.480838568866215 0.618050781901943 0.5494446753840789 0.1372122130357279 0 0 0 0 K07320 0.0028571428571428 0.1054131054131054 prmB; ribosomal protein L3 glutamine methyltransferase [EC:2.1.1.298] 255.0 38.0 0.0 1.0 1.0 J 1.0 37.0 1.0 1.0 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 38.0 0.0263157894736842 0.9736842105263158 0.770504966015569 0.0286502965122002 0.3995776312638845 0.7418546695033688 0 0 1 1 K07321 0.2742857142857143 0.1168091168091168 cooC; CO dehydrogenase maturation factor 118.0 283.0 0.0 1.0 1.0 D 216.0 67.0 1.0 1.0 COG3640 CO_dehydrogenase_nickel-insertion_accessory_protein_CooC1 CooC 283.0 0.7632508833922261 0.2367491166077738 0.957948534368894 0.981834216642965 0.9698913755059296 0.0238856822740709 1 1 1 1 K07322 0.0485714285714285 0.1566951566951566 ytfE, scdA; regulator of cell morphogenesis and NO signaling 28.0 62.0 47.0 4.0 0.746987951807229 D 17.0 66.0 5.0 0.783132530120482 COG2846 Iron-sulfur_cluster_repair_protein_YtfE,_RIC_family,_contains_ScdAN_and_hemerythrin_domains RIC 83.0 0.2048192771084337 0.7951807228915663 0.0612877972695899 0.302009587465584 0.1816486923675869 0.2407217901959941 0 0 0 0 K07323 0.0 0.2193732193732193 mlaC; phospholipid transport system substrate-binding protein path:map02010 ABC transporters 65.0 99.0 0.0 1.0 1.0 Q 0.0 99.0 1.0 1.0 COG2854 Periplasmic_subunit_MlaC_of_the_ABC-type_intermembrane_phospholipid_transporter_Mla MlaC 99.0 0.0 1.0 0.0002328984781793 0.0005484084761588 0.000390653477169 0.0003155099979795 0 0 0 0 K07324 0.0285714285714285 0.0 flaA; archaeal flagellin FlaA 151.0 30.0 0.0 1.0 1.0 N 30.0 0.0 1.0 1.0 COG1681 Archaellin_(archaeal_flagellin) FlaB 30.0 1.0 0.0 0.0003592818305002 0.0007476325961716 0.0005534572133359 0.0003883507656713 0 0 0 0 K07325 0.3342857142857143 0.0 flaB; archaeal flagellin FlaB 72.0 291.0 0.0 1.0 1.0 N 291.0 0.0 1.0 1.0 COG1681 Archaellin_(archaeal_flagellin) FlaB 291.0 1.0 0.0 0.54388549783365 0.200236153141906 0.372060825487778 0.343649344691744 0 0 0 1 K07326 0.0 0.0142450142450142 fhaC; hemolysin activation/secretion protein path:map05133 Pertussis 535.0 6.0 0.0 1.0 1.0 U 0.0 6.0 1.0 1.0 COG2831 Hemolysin_activation/secretion_protein FhaC 6.0 0.0 1.0 0.0357783018802262 0.0614296146339938 0.04860395825711 0.0256513127537676 0 0 0 0 K07327 0.1771428571428571 0.0 flaD; archaeal flagellar protein FlaD 72.0 73.0 0.0 1.0 1.0 N 73.0 0.0 2.0 0.931506849315068 COG3351 Archaellum_component_ArlD/FlaD/FlaE FlaD 73.0 1.0 0.0 0.370326518876817 0.51803023545047 0.4441783771636435 0.147703716573653 0 0 0 0 K07328 0.1542857142857142 0.0 flaE; archaeal flagellar protein FlaE 82.0 82.0 0.0 1.0 1.0 N 82.0 0.0 2.0 0.792682926829268 COG3351 Archaellum_component_ArlD/FlaD/FlaE FlaD 82.0 1.0 0.0 0.0201916813735969 0.0075153836987082 0.0138535325361525 0.0126762976748887 0 0 0 0 K07329 0.2685714285714285 0.0 flaF; archaeal flagellar protein FlaF 68.0 106.0 0.0 1.0 1.0 N 106.0 0.0 2.0 0.971698113207547 COG3353 Archaellum_component_FlaF,_FlaF/FlaG_flagellin_family FlaF 106.0 1.0 0.0 0.757192148787484 0.637094744074269 0.6971434464308766 0.1200974047132149 0 0 1 1 K07330 0.2971428571428571 0.0 flaG; archaeal flagellar protein FlaG 67.0 118.0 0.0 1.0 1.0 N 118.0 0.0 1.0 1.0 COG3354 Archaellum_component_FlaG,_FlaF/FlaG_flagellin_family FlaG 118.0 1.0 0.0 0.821876208145953 0.937361893353323 0.879619050749638 0.11548568520737 0 0 1 1 K07331 0.3342857142857143 0.0 flaH; archaeal flagellar protein FlaH 172.0 80.0 23.0 2.0 0.583941605839416 N 137.0 0.0 2.0 0.875912408759124 COG2874 Archaellum_biogenesis_ATPase_ArlH/FlaH FlaH 137.0 1.0 0.0 0.959906714153794 0.964189653373289 0.9620481837635416 0.0042829392194949 0 0 1 1 K07332 0.8742857142857143 0.0028490028490028 flaI; archaeal flagellar protein FlaI 132.0 542.0 313.0 9.0 0.660975609756098 N 819.0 1.0 11.0 0.882926829268293 COG4962 Pilus_assembly_protein,_ATPase_of_CpaF_family CpaF 820.0 0.998780487804878 0.0012195121951219 0.879610036243447 0.923992181584683 0.901801108914065 0.0443821453412359 0 0 1 1 K07333 0.8285714285714286 0.0 flaJ; archaeal flagellar protein FlaJ 19.0 789.0 718.0 3.0 0.916376306620209 N 867.0 0.0 5.0 0.821222606689735 COG2064 Flp_pilus_assembly_protein_TadC TadC 867.0 1.0 0.0 0.0317522047993935 0.298086303487913 0.1649192541436532 0.2663340986885195 0 0 0 0 K07334 0.0 0.188034188034188 higB-1; toxin HigB-1 68.0 96.0 94.0 3.0 0.96 S 0.0 100.0 3.0 0.96 COG3549 Plasmid_maintenance_system_killer_protein HigB 100.0 0.0 1.0 0.024480624403943 0.0382324875341247 0.0313565559690338 0.0137518631301816 0 0 0 0 K07335 0.2142857142857142 0.3703703703703703 bmpA, bmpB, tmpC; basic membrane protein A and related proteins path:map02010 ABC transporters 96.0 269.0 230.0 4.0 0.802985074626866 S 113.0 221.0 1.0 1.0 COG1744 Lipoprotein_Med,_regulator_of_KinD/Spo0A,_PBP1-ABC_superfamily,_includes_NupN Med 334.0 0.3383233532934132 0.6616766467065869 0.435372059959649 0.803548002391958 0.6194600311758035 0.368175942432309 0 0 0 0 K07336 0.0 0.1139601139601139 K07336; PKHD-type hydroxylase [EC:1.14.11.-] 124.0 26.0 11.0 3.0 0.553191489361702 S 0.0 47.0 2.0 0.936170212765958 COG3128 Predicted_2-oxoglutarate-_and_Fe(II)-dependent_dioxygenase_YbiX PiuC 47.0 0.0 1.0 0.0075394058456525 0.0159541812484746 0.0117467935470635 0.0084147754028221 0 0 0 0 K07337 0.0 0.0997150997150997 K07337; penicillin-binding protein activator 120.0 36.0 0.0 1.0 1.0 M 0.0 36.0 1.0 1.0 COG3417 Outer_membrane_lipoprotein_LpoB,_binds_and_activates_PBP1b LpoB 36.0 0.0 1.0 0.0063983312856328 0.0296798234936912 0.018039077389662 0.0232814922080584 0 0 0 0 K07338 0.0 0.0683760683760683 K07338; uncharacterized protein 203.0 25.0 0.0 1.0 1.0 S 0.0 25.0 1.0 1.0 COG3489 Imelysin-like_iron-regulated_protein_IrpA,_duplicated_M75_peptidase-like_domain IrpA2 25.0 0.0 1.0 0.0107587978032458 0.0234934743449373 0.0171261360740915 0.0127346765416915 0 0 0 0 K07339 0.0285714285714285 0.0712250712250712 hicA; mRNA interferase HicA [EC:3.1.-.-] 46.0 36.0 35.0 3.0 0.947368421052632 N 11.0 29.0 3.0 0.925 COG1724 Predicted_RNA_binding_protein_YcfA,_dsRBD-like_fold,_HicA-like_mRNA_interferase_family YcfA 40.0 0.275 0.725 0.30274952561432 0.225342388071964 0.264045956843142 0.077407137542356 0 0 0 0 K07340 0.0028571428571428 0.1225071225071225 ybbJ; inner membrane protein 72.0 41.0 39.0 2.0 0.953488372093023 OU 1.0 43.0 3.0 0.931818181818182 COG1585 Membrane_protein_implicated_in_regulation_of_membrane_protease_activity YbbJ 44.0 0.0227272727272727 0.9772727272727272 0.673561058520378 0.385166403844628 0.529363731182503 0.2883946546757499 0 0 0 1 K07341 0.1542857142857142 0.2478632478632478 doc; death on curing protein 44.0 128.0 0.0 1.0 1.0 S 60.0 94.0 2.0 0.748387096774194 COG3654 Prophage_maintenance_system_killer_protein Doc 154.0 0.3896103896103896 0.6103896103896104 0.0036128181475577 0.0055201002453341 0.0045664591964459 0.0019072820977764 0 0 0 0 K07342 0.6742857142857143 0.0 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins path:map03060,path:map04141,path:map04145,path:map05110 Protein export,Protein processing in endoplasmic reticulum,Phagosome,Vibrio cholerae infection 37.0 236.0 0.0 1.0 1.0 U 236.0 0.0 1.0 1.0 COG2443 Preprotein_translocase_subunit_Sss1 Sss1 236.0 1.0 0.0 0.188589755830291 0.0610598489988788 0.1248248024145849 0.1275299068314122 0 0 0 0 K07343 0.0 0.0 tfoX; DNA transformation protein and related proteins 42.0 24.0 2.0 0.7 K 0.0 0.0 4.0 0.7 COG3070 Transcriptional_regulator_of_competence_genes,_TfoX/Sxy_family TfoX 0.0 0 0 0 0 K07344 0.0 0.0512820512820512 trbL; type IV secretion system protein TrbL path:map02024 Quorum sensing 266.0 40.0 0.0 1.0 1.0 U 0.0 43.0 4.0 0.822222222222222 COG3846 Type_IV_secretory_pathway,_TrbL_components TrbL 43.0 0.0 1.0 0.0081741351446254 0.0237187241169318 0.0159464296307786 0.0155445889723064 0 0 0 0 K07345 0.0 0.0142450142450142 fimA; major type 1 subunit fimbrin (pilin) path:map05131,path:map05133 Shigellosis,Pertussis 155.0 14.0 0.0 1.0 1.0 NU 0.0 14.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 14.0 0.0 1.0 0.006597778842055 0.0099747098624095 0.0082862443522322 0.0033769310203545 0 0 0 0 K07346 0.0 0.0512820512820512 fimC; fimbrial chaperone protein 118.0 18.0 11.0 2.0 0.72 NU 0.0 25.0 1.0 1.0 COG3121 P_pilus_assembly_protein,_chaperone_PapD FimC 25.0 0.0 1.0 0.0285836478802684 0.0642653597981428 0.0464245038392056 0.0356817119178743 0 0 0 0 K07347 0.0 0.0598290598290598 fimD, fimC, mrkC, htrE, cssD; outer membrane usher protein path:map05133 Pertussis 296.0 35.0 33.0 2.0 0.945945945945946 NU 0.0 37.0 1.0 1.0 COG3188 Outer_membrane_usher_protein_FimD/PapC FimD 37.0 0.0 1.0 0.0170271212472549 0.0305617137452594 0.0237944174962571 0.0135345924980045 0 0 0 0 K07348 0.0 0.0056980056980056 fimF; minor fimbrial subunit 168.0 3.0 0.0 1.0 1.0 NU 0.0 3.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 3.0 0.0 1.0 0 0 0 0 K07349 0.0 0.0028490028490028 fimG; minor fimbrial subunit 167.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 2.0 0.0 1.0 0 0 0 0 K07350 0.0 0.0056980056980056 fimH; minor fimbrial subunit 219.0 4.0 0.0 1.0 1.0 NU 0.0 4.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 4.0 0.0 1.0 8.30102369744612e-12 1.3244734466609099e-11 1.0772879082027612e-11 4.943710769162981e-12 0 0 0 0 K07351 0.0 0.0028490028490028 fimI; fimbrial protein 165.0 1.0 0.0 1.0 1.0 NU 0.0 1.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 1.0 0.0 1.0 0 0 0 0 K07352 0.0 0.0028490028490028 sfmA; type 1 fimbrial protein 180.0 1.0 0.0 1.0 1.0 NU 0.0 1.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 1.0 0.0 1.0 0 0 0 0 K07353 0.0 0.0056980056980056 sfmC; fimbrial chaperone protein 101.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG3121 P_pilus_assembly_protein,_chaperone_PapD FimC 2.0 0.0 1.0 0 0 0 0 K07354 0.0 0.0056980056980056 sfmD; outer membrane usher protein 853.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG3188 Outer_membrane_usher_protein_FimD/PapC FimD 2.0 0.0 1.0 0 0 0 0 K07355 0.0 0.0056980056980056 sfmF; fimbrial-like protein 169.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 2.0 0.0 1.0 0 0 0 0 K07356 0.0 0.0056980056980056 sfmH; fimbrial protein 322.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG3539 Pilin_(type_1_fimbrial_protein) FimA 2.0 0.0 1.0 0 0 0 0 K07357 0.0 0.0142450142450142 fimB; type 1 fimbriae regulatory protein FimB 178.0 6.0 5.0 2.0 0.857142857142857 L 0.0 7.0 2.0 0.857142857142857 COG4974 Site-specific_recombinase_XerD XerD 7.0 0.0 1.0 0.0742037965892018 0.149731076819636 0.1119674367044188 0.0755272802304341 0 0 0 0 K07358 0.0 0.0142450142450142 fimE; type 1 fimbriae regulatory protein FimE 116.0 4.0 3.0 2.0 0.8 L 0.0 5.0 1.0 1.0 COG4974 Site-specific_recombinase_XerD XerD 5.0 0.0 1.0 0.165617557208304 0.309219356270937 0.2374184567396205 0.1436017990626329 0 0 0 0 K07374 0.0057142857142857 0.0 TUBA; tubulin alpha path:map04145,path:map04210,path:map04530,path:map04540,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05130,path:map05132 Phagosome,Apoptosis,Tight junction,Gap junction,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Pathogenic Escherichia coli infection,Salmonella infection 57.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG1997 Ribosomal_protein_L37AE/L43A RPL43A 2.0 1.0 0.0 0 0 0 0 K07375 0.0028571428571428 0.0 TUBB; tubulin beta path:map04145,path:map04540,path:map05010,path:map05012,path:map05014,path:map05016,path:map05020,path:map05022,path:map05130,path:map05132 Phagosome,Gap junction,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Prion disease,Pathways of neurodegeneration - multiple diseases,Pathogenic Escherichia coli infection,Salmonella infection 425.0 1.0 0.0 1.0 1.0 Z 1.0 0.0 1.0 1.0 COG5023 Tubulin 1.0 1.0 0.0 0 0 0 0 K07386 0.0485714285714285 0.1908831908831909 pepO; putative endopeptidase [EC:3.4.24.-] 503.0 113.0 0.0 1.0 1.0 O 19.0 94.0 1.0 1.0 COG3590 Predicted_metalloendopeptidase PepO 113.0 0.168141592920354 0.831858407079646 0.0043945555182938 0.0331796441815013 0.0187870998498975 0.0287850886632075 0 0 0 0 K07387 0.0 0.0569800569800569 K07387; metalloprotease [EC:3.4.24.-] 207.0 13.0 6.0 3.0 0.619047619047619 O 0.0 21.0 3.0 0.904761904761905 COG0501 Zn-dependent_protease_with_chaperone_function HtpX 21.0 0.0 1.0 0.0465545043686483 0.126372090049859 0.0864632972092536 0.0798175856812107 0 0 0 0 K07388 0.1942857142857142 0.0 K07388; hydrogenase expression/formation protein 391.0 68.0 0.0 1.0 1.0 O 68.0 0.0 1.0 1.0 COG1973 Hydrogenase_maturation_factor_HypE HypE2 68.0 1.0 0.0 0.826788316087832 0.252114570514347 0.5394514433010895 0.5746737455734849 0 0 1 1 K07389 0.0 0.0056980056980056 cyaC, hlyC, rtxC; cytolysin-activating lysine-acyltransferase [EC:2.3.1.-] path:map05133 Pertussis 139.0 2.0 0.0 1.0 1.0 O 0.0 2.0 1.0 1.0 COG2994 ACP:hemolysin_acyltransferase_(hemolysin-activating_protein) HlyC 2.0 0.0 1.0 0 0 0 0 K07390 0.1485714285714285 0.2735042735042735 grxD, GLRX5; monothiol glutaredoxin 79.0 82.0 14.0 5.0 0.535947712418301 O 52.0 101.0 5.0 0.915032679738562 COG0278 Glutaredoxin-related_protein GrxD 153.0 0.3398692810457516 0.6601307189542484 0.0022453147888753 0.0058437659726366 0.0040445403807559 0.0035984511837612 0 0 0 0 K07391 0.0 0.8746438746438746 comM; magnesium chelatase family protein 344.0 343.0 338.0 2.0 0.985632183908046 O 0.0 348.0 2.0 0.985632183908046 COG0606 Predicted_Mg-chelatase,_contains_ChlI-like_and_ATPase_domains,_YifB_family YifB 348.0 0.0 1.0 0.818249597421456 0.900414147367211 0.8593318723943335 0.082164549945755 0 0 1 1 K07392 0.1371428571428571 0.0 PRS2; AAA family ATPase 310.0 50.0 0.0 1.0 1.0 O 50.0 0.0 1.0 1.0 COG1223 Predicted_ATPase,_AAA+_superfamily 50.0 1.0 0.0 0.909677068976655 0.990641755195847 0.950159412086251 0.0809646862191919 0 0 1 1 K07393 0.1171428571428571 0.1965811965811965 ECM4, yqjG; glutathionyl-hydroquinone reductase [EC:1.8.5.7] 248.0 131.0 0.0 1.0 1.0 O 46.0 85.0 1.0 1.0 COG0435 Glutathionyl-hydroquinone_reductase ECM4 131.0 0.3511450381679389 0.648854961832061 0.0070122175914109 0.0295823656022966 0.0182972915968537 0.0225701480108857 0 0 0 0 K07394 0.0 0.094017094017094 K07394; SM-20-related protein 119.0 36.0 0.0 1.0 1.0 O 0.0 36.0 1.0 1.0 COG3751 Proline_4-hydroxylase_(includes_Rps23_Pro-64_3,4-dihydroxylase_Tpa1),_contains_SM-20_domain EGL9 36.0 0.0 1.0 0.0194317849384071 0.0399602028247204 0.0296959938815637 0.0205284178863133 0 0 0 0 K07395 0.0 0.1111111111111111 K07395; putative proteasome-type protease 198.0 37.0 0.0 1.0 1.0 O 0.0 40.0 1.0 1.0 COG3484 Predicted_proteasome-type_protease 40.0 0.0 1.0 0.0113966983422699 0.0485371917062969 0.0299669450242834 0.037140493364027 0 0 0 0 K07396 0.0 0.0569800569800569 K07396; putative protein-disulfide isomerase 155.0 23.0 0.0 1.0 1.0 O 0.0 23.0 1.0 1.0 COG3531 Predicted_protein-disulfide_isomerase,_contains_CxxC_motif 23.0 0.0 1.0 0.0529072522084779 0.110696655675836 0.0818019539421569 0.0577894034673581 0 0 0 0 K07397 0.24 0.4102564102564102 yhfA; putative redox protein 27.0 243.0 197.0 2.0 0.84083044982699 O 89.0 180.0 3.0 0.705882352941177 COG1765 Uncharacterized_OsmC-related_protein YhfA 269.0 0.3308550185873606 0.6691449814126395 0.0760007697217103 0.21661198982275 0.1463063797722301 0.1406112201010397 0 0 0 0 K07398 0.4142857142857143 0.0 K07398; conserved protein with predicted RNA binding PUA domain 134.0 147.0 0.0 1.0 1.0 O 147.0 0.0 1.0 1.0 COG1370 tRNA-guanine_transglycosylase,_archaeosine-15-forming,_contains_TGT_and_PUA_domains ArcTGT 147.0 1.0 0.0 0.195018155581261 0.94198282935633 0.5685004924687955 0.746964673775069 0 0 0 0 K07399 0.0114285714285714 0.2621082621082621 resB, ccs1; cytochrome c biogenesis protein 170.0 102.0 0.0 1.0 1.0 O 4.0 98.0 1.0 1.0 COG1333 Cytochrome_c_biogenesis_protein_ResB ResB 102.0 0.0392156862745098 0.9607843137254902 0.0081155132647397 0.724285364527908 0.3662004388963238 0.7161698512631683 0 0 0 0 K07400 0.0285714285714285 0.0997150997150997 nfuA; Fe/S biogenesis protein NfuA 122.0 25.0 10.0 3.0 0.520833333333333 O 10.0 38.0 2.0 0.708333333333333 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 48.0 0.2083333333333333 0.7916666666666666 0.0209564425377201 0.121537617869504 0.071247030203612 0.1005811753317839 0 0 0 0 K07401 0.1028571428571428 0.0797720797720797 K07401; selenoprotein W-related protein 74.0 54.0 39.0 2.0 0.782608695652174 O 42.0 28.0 4.0 0.585714285714286 arCOG06207 70.0 0.6 0.4 0.0047472003171766 0.0597921325358311 0.0322696664265038 0.0550449322186545 0 0 0 0 K07402 0.18 0.4387464387464387 xdhC; xanthine dehydrogenase accessory factor 49.0 285.0 262.0 8.0 0.866261398176292 O 70.0 258.0 8.0 0.875379939209727 COG1975 Molybdoenzyme_maturation_factor_PaoD_(Mo_cofactor_insertion),_XdhC/CoxF_family XdhC 328.0 0.2134146341463414 0.7865853658536586 0.0175346614921198 0.173738225939077 0.0956364437155984 0.1562035644469572 0 0 0 0 K07403 0.26 0.3675213675213675 nfeD; membrane-bound serine protease (ClpP class) 202.0 237.0 0.0 1.0 1.0 O 113.0 141.0 1.0 1.0 COG1030 Membrane-bound_serine_protease_NfeD,_ClpP_class NfeD 254.0 0.4448818897637795 0.5551181102362205 0.761065864047071 0.988314733261476 0.8746902986542735 0.227248869214405 1 1 1 1 K07404 0.0228571428571428 0.1766381766381766 pgl; 6-phosphogluconolactonase [EC:3.1.1.31] path:map00030,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 209.0 78.0 73.0 4.0 0.886363636363636 G 10.0 78.0 2.0 0.909090909090909 COG2706 6-phosphogluconolactonase,_cycloisomerase_2_family Pgl 88.0 0.1136363636363636 0.8863636363636364 0.0069945595297562 0.153106359400181 0.0800504594649686 0.1461117998704248 0 0 0 0 K07405 0.3314285714285714 0.0598290598290598 E3.2.1.1A; alpha-amylase [EC:3.2.1.1] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 301.0 153.0 0.0 1.0 1.0 G 129.0 24.0 2.0 0.967320261437908 COG1449 Alpha-amylase/alpha-mannosidase,_GH57_family 153.0 0.8431372549019608 0.1568627450980392 0.971842536099807 0.972830756667713 0.97233664638376 0.000988220567906 1 1 1 1 K07406 0.0685714285714285 0.0997150997150997 melA; alpha-galactosidase [EC:3.2.1.22] path:map00052,path:map00561,path:map00600,path:map00603,path:map01100 Galactose metabolism,Glycerolipid metabolism,Sphingolipid metabolism,Glycosphingolipid biosynthesis - globo and isoglobo series,Metabolic pathways 247.0 115.0 0.0 1.0 1.0 G 51.0 64.0 1.0 1.0 COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase,_family_4_of_glycosyl_hydrolase CelF 115.0 0.4434782608695652 0.5565217391304348 0.608454267010183 0.777024085460239 0.6927391762352111 0.168569818450056 0 1 0 1 K07407 0.0371428571428571 0.2421652421652421 E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] path:map00052,path:map00561,path:map00600,path:map00603,path:map01100 Galactose metabolism,Glycerolipid metabolism,Sphingolipid metabolism,Glycosphingolipid biosynthesis - globo and isoglobo series,Metabolic pathways 16.0 170.0 165.0 5.0 0.923913043478261 G 13.0 169.0 10.0 0.717391304347826 COG3345 Alpha-galactosidase GalA 182.0 0.0714285714285714 0.9285714285714286 0.15238719665473 0.0517766508767787 0.1020819237657543 0.1006105457779513 0 0 0 0 K07432 0.0057142857142857 0.0 ALG13; beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.141] path:map00510,path:map00513,path:map01100 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways 149.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 COG5017 UDP-N-acetylglucosamine_transferase_subunit_ALG13 2.0 1.0 0.0 0 0 0 0 K07441 0.0057142857142857 0.0 ALG14; beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.141] path:map00510,path:map00513,path:map01100 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways 157.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 KOG3339 2.0 1.0 0.0 0 0 0 0 K07442 0.78 0.1908831908831909 TRM61, GCD14; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220] 110.0 253.0 164.0 2.0 0.739766081871345 J 274.0 68.0 3.0 0.988304093567252 COG2519 tRNA_A58_N-methylase_Trm61 Gcd14 342.0 0.8011695906432749 0.1988304093567251 0.882918271571317 0.703390247018015 0.793154259294666 0.1795280245533019 1 1 1 1 K07443 0.0114285714285714 0.2678062678062678 ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein 55.0 99.0 98.0 2.0 0.99 L 4.0 96.0 2.0 0.97 COG3695 Alkylated_DNA_nucleotide_flippase_Atl1,_participates_in_nucleotide_excision_repair,_Ada-like_DNA-binding_domain Atl1 100.0 0.04 0.96 0.0201215280349186 0.636023747453529 0.3280726377442238 0.6159022194186103 0 0 0 0 K07444 0.1028571428571428 0.3304843304843304 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] 156.0 136.0 106.0 2.0 0.819277108433735 L 37.0 129.0 1.0 1.0 COG0116 23S_rRNA_G2445_N2-methylase_RlmL RlmL 166.0 0.2228915662650602 0.7771084337349398 0.0132809982145756 0.384191511570869 0.1987362548927223 0.3709105133562934 0 0 0 0 K07445 0.0 0.0 K07445; putative DNA methylase 96.0 93.0 2.0 0.96969696969697 L 0.0 0.0 2.0 0.96969696969697 COG1743 Adenine-specific_DNA_methylase,_contains_a_Zn-ribbon_domain 0.0 0 0 0 0 K07446 0.7028571428571428 0.0056980056980056 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213] 113.0 109.0 22.0 3.0 0.436 L 248.0 2.0 1.0 1.0 COG1041 tRNA_G10_N-methylase_Trm11 Trm11 250.0 0.992 0.008 0.969354581428613 0.127736910584528 0.5485457460065705 0.841617670844085 0 0 1 1 K07447 0.0 0.8603988603988604 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-] 51.0 202.0 100.0 4.0 0.653721682847896 L 0.0 309.0 3.0 0.983818770226537 COG0816 YqgF/RuvX_protein,_pre-16S_rRNA_maturation_RNase/Holliday_junction_resolvase/anti-termination_factor YqgF 309.0 0.0 1.0 0.159829589442003 0.847237323031902 0.5035334562369526 0.687407733589899 0 0 0 0 K07448 0.0 0.0 mrr; restriction system protein 137.0 65.0 6.0 0.60352422907489 V 0.0 0.0 17.0 0.418502202643172 COG1715 Restriction_endonuclease_Mrr Mrr 0.0 0 0 0 0 K07449 0.0 0.0085470085470085 K07449; similar to archaeal holliday junction resolvase and Mrr protein 143.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1787 Endonuclease,_HJR/Mrr/RecB_family 3.0 0.0 1.0 0 0 0 0 K07450 0.0857142857142857 0.0256410256410256 K07450; putative resolvase 74.0 116.0 0.0 1.0 1.0 L 69.0 25.0 1.0 1.0 COG2452 Predicted_site-specific_integrase-resolvase 94.0 0.7340425531914894 0.2659574468085106 0.0852075573490215 0.0149362935440305 0.050071925446526 0.0702712638049909 0 0 0 0 K07451 0.0914285714285714 0.2421652421652421 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 10.0 120.0 62.0 3.0 0.666666666666667 V 35.0 140.0 9.0 0.700534759358289 COG1403 5-methylcytosine-specific_restriction_endonuclease_McrA McrA 175.0 0.2 0.8 0.164540141175323 0.143342078069793 0.153941109622558 0.02119806310553 0 0 0 0 K07452 0.0 0.0 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-] 82.0 59.0 10.0 0.5125 V 0.0 0.0 22.0 0.35 COG1401 5-methylcytosine-specific_restriction_endonuclease_McrBC,_GTP-binding_regulatory_subunit_McrB McrB 0.0 0 0 0 0 K07453 0.0057142857142857 0.017094017094017 K07453; putative restriction endonuclease 103.0 5.0 2.0 2.0 0.625 L 2.0 6.0 3.0 0.75 COG3183 Predicted_restriction_endonuclease,_HNH_family 8.0 0.25 0.75 0.190622015045489 0.35838558858843 0.2745038018169595 0.167763573542941 0 0 0 0 K07454 0.12 0.1424501424501424 K07454; putative restriction endonuclease 33.0 72.0 54.0 4.0 0.666666666666667 V 49.0 58.0 9.0 0.573913043478261 COG3440 Predicted_restriction_endonuclease 107.0 0.4579439252336448 0.5420560747663551 0.0409422347888224 0.230545539930235 0.1357438873595287 0.1896033051414126 0 0 0 0 K07455 0.0028571428571428 0.0484330484330484 recT; recombination protein RecT 151.0 21.0 0.0 1.0 1.0 L 1.0 20.0 2.0 0.952380952380952 COG3723 Recombinational_DNA_repair_protein_RecT RecT 21.0 0.0476190476190476 0.9523809523809524 0.0825300072834881 0.234267365668075 0.1583986864757815 0.1517373583845869 0 0 0 0 K07456 0.2885714285714286 0.5156695156695157 mutS2; DNA mismatch repair protein MutS2 path:map03430 Mismatch repair 204.0 349.0 346.0 2.0 0.991477272727273 L 137.0 213.0 2.0 0.988636363636364 COG1193 dsDNA-specific_endonuclease/ATPase_MutS2 MutS2 350.0 0.3914285714285714 0.6085714285714285 0.897339024947887 0.722107508568034 0.8097232667579605 0.175231516379853 1 1 1 1 K07457 0.2828571428571428 0.1766381766381766 K07457; endonuclease III related protein 107.0 163.0 0.0 1.0 1.0 L 101.0 62.0 2.0 0.969325153374233 COG2231 3-Methyladenine_DNA_glycosylase,_HhH-GPD/Endo3_superfamily HP0602 163.0 0.6196319018404908 0.3803680981595092 0.789121717964532 0.541159658489638 0.6651406882270849 0.247962059474894 1 1 1 1 K07458 0.0542857142857142 0.1538461538461538 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] 79.0 84.0 83.0 2.0 0.988235294117647 L 19.0 66.0 2.0 0.976470588235294 COG3727 G:T-mismatch_repair_DNA_endonuclease_Vsr,_very_short_patch_repair_protein Vsr 85.0 0.2235294117647059 0.7764705882352941 0.477836536150452 0.772384077851992 0.625110307001222 0.29454754170154 0 0 0 0 K07459 0.0371428571428571 0.1566951566951566 ybjD; putative ATP-dependent endonuclease of the OLD family 78.0 76.0 69.0 2.0 0.91566265060241 L 14.0 68.0 8.0 0.409638554216867 COG1195 Recombinational_DNA_repair_ATPase_RecF RecF 82.0 0.1707317073170731 0.8292682926829268 0.635821515291277 0.830641779791951 0.733231647541614 0.194820264500674 0 1 0 1 K07460 0.0314285714285714 0.8433048433048433 yraN; putative endonuclease 34.0 290.0 281.0 3.0 0.963455149501661 L 11.0 298.0 3.0 0.964401294498382 COG0792 Predicted_endonuclease_distantly_related_to_archaeal_Holliday_junction_resolvase,_YraN/UPF0102_family YraN 309.0 0.0355987055016181 0.964401294498382 0.0363875282443802 0.544675128564149 0.2905313284042646 0.5082876003197688 0 0 0 0 K07461 0.1885714285714285 0.4786324786324786 K07461; putative endonuclease 15.0 383.0 372.0 3.0 0.969620253164557 L 67.0 328.0 4.0 0.956962025316456 COG2827 Predicted_endonuclease,_GIY-YIG_superfamily YhbQ 395.0 0.1696202531645569 0.830379746835443 0.0300079222387842 0.703058462792514 0.3665331925156491 0.6730505405537298 0 0 0 0 K07462 0.1057142857142857 0.8490028490028491 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] path:map03410,path:map03430,path:map03440 Base excision repair,Mismatch repair,Homologous recombination 156.0 376.0 0.0 1.0 1.0 L 37.0 339.0 3.0 0.968085106382979 COG0608 ssDNA-specific_exonuclease_RecJ,_DHH_superfamily,_may_be_involved_in_archaeal_DNA_replication_intiation RecJ 376.0 0.0984042553191489 0.901595744680851 0.0193116657263131 0.723057444622475 0.3711845551743941 0.7037457788961619 0 0 0 0 K07463 0.7742857142857142 0.0056980056980056 K07463; archaea-specific RecJ-like exonuclease 52.0 500.0 0.0 1.0 1.0 L 493.0 2.0 3.0 0.728 COG0608 ssDNA-specific_exonuclease_RecJ,_DHH_superfamily,_may_be_involved_in_archaeal_DNA_replication_intiation RecJ 495.0 0.995959595959596 0.004040404040404 0.535038726343491 0.388441233550719 0.461739979947105 0.146597492792772 0 0 0 1 K07464 0.0 0.0 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] 319.0 158.0 4.0 0.648373983739837 L 0.0 0.0 6.0 0.853107344632768 COG1468 CRISPR/Cas_system-associated_exonuclease_Cas4,_RecB_family Cas4 0.0 0 0 0 0 K07465 0.1514285714285714 0.188034188034188 K07465; putative RecB family exonuclease 52.0 154.0 0.0 1.0 1.0 L 56.0 98.0 6.0 0.694805194805195 COG2887 RecB_family_exonuclease Slr0479 154.0 0.3636363636363636 0.6363636363636364 0.0807144672819532 0.978885513523812 0.5297999904028826 0.8981710462418588 0 0 0 0 K07466 0.92 0.0028490028490028 RFA1, RPA1, rpa; replication factor A1 path:map03030,path:map03420,path:map03430,path:map03440,path:map03460 DNA replication,Nucleotide excision repair,Mismatch repair,Homologous recombination,Fanconi anemia pathway 5.0 639.0 637.0 2.0 0.996879875195008 L 569.0 1.0 4.0 0.984399375975039 COG1599 ssDNA-binding_replication_factor_A,_large_subunit RFA1 570.0 0.9982456140350876 0.0017543859649122 0.288659281487893 0.105564107673765 0.197111694580829 0.183095173814128 0 0 0 0 K07467 0.0028571428571428 0.0284900284900284 nicK; putative DNA relaxase 33.0 8.0 2.0 2.0 0.571428571428571 K 1.0 13.0 3.0 0.5 COG2946 DNA_relaxase_NicK NicK 14.0 0.0714285714285714 0.9285714285714286 0.0129144606314692 0.0259749537104815 0.0194447071709753 0.0130604930790122 0 0 0 0 K07468 0.1914285714285714 0.0199430199430199 K07468; putative ATP-dependent DNA ligase [EC:6.5.1.1] 264.0 76.0 0.0 1.0 1.0 L 69.0 7.0 1.0 1.0 COG1423 ATP-dependent_RNA_circularization_protein,_DNA/RNA_ligase_(PAB1020)__family 76.0 0.9078947368421052 0.0921052631578947 0.726906327507933 0.367013408496988 0.5469598680024605 0.359892919010945 0 1 0 1 K07469 0.0 0.0341880341880341 mop; aldehyde oxidoreductase [EC:1.2.99.7] 852.0 17.0 0.0 1.0 1.0 C 0.0 17.0 2.0 0.941176470588235 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 17.0 0.0 1.0 0.0484372636679447 0.101325588515923 0.0748814260919338 0.0528883248479783 0 0 0 0 K07470 0.0 0.0056980056980056 sbmC; DNA gyrase inhibitor 145.0 1.0 0.0 2.0 0.5 L 0.0 2.0 2.0 0.5 COG3449 DNA_gyrase_inhibitor_GyrI/SbmC SbmC 2.0 0.0 1.0 0 0 0 0 K07471 0.0 0.0028490028490028 ygiV; probable transcriptional regulator 160.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG3449 DNA_gyrase_inhibitor_GyrI/SbmC SbmC 1.0 0.0 1.0 0 0 0 0 K07472 0.1828571428571428 0.0 TIP49; TBP-interacting protein 424.0 61.0 53.0 2.0 0.884057971014493 K 69.0 0.0 1.0 1.0 COG1224 DNA_helicase_TIP49,_TBP-interacting_protein TIP49 69.0 1.0 0.0 0.838084053450037 0.97354639732284 0.9058152253864384 0.1354623438728029 0 0 1 1 K07473 0.0028571428571428 0.1538461538461538 dinJ; DNA-damage-inducible protein J 57.0 83.0 82.0 2.0 0.988095238095238 L 1.0 83.0 1.0 1.0 COG3077 Antitoxin_component_of_the_RelBE_or_YafQ-DinJ_toxin-antitoxin_module RelB 84.0 0.0119047619047619 0.988095238095238 0.034087488438 0.31500760756464 0.17454754800132 0.28092011912664 0 0 0 0 K07474 0.0028571428571428 0.0655270655270655 xtmA; phage terminase small subunit 81.0 29.0 0.0 1.0 1.0 L 2.0 28.0 2.0 0.966666666666667 COG3728 Phage_terminase,_small_subunit XtmA 30.0 0.0666666666666666 0.9333333333333332 0.0912502599244496 0.243198728706949 0.1672244943156993 0.1519484687824994 0 0 0 0 K07475 0.2 0.0028490028490028 cas3; CRISPR-associated endonuclease Cas3-HD [EC:3.1.-.-] 53.0 43.0 12.0 3.0 0.544303797468354 L 77.0 1.0 2.0 0.544303797468354 COG2254 CRISPR/Cas_system-associated_endonuclease_Cas3-HD Cas3 78.0 0.9871794871794872 0.0128205128205128 0.743499769375838 0.932985005713577 0.8382423875447075 0.189485236337739 0 0 0 1 K07476 0.0085714285714285 0.0284900284900284 yusF; toprim domain protein 95.0 13.0 0.0 1.0 1.0 L 3.0 10.0 1.0 1.0 COG1658 5S_rRNA_maturation_ribonuclease_M5,_contains_TOPRIM_domain RnmV 13.0 0.2307692307692307 0.7692307692307693 0.028425516402115 0.111902783939491 0.070164150170803 0.083477267537376 0 0 0 0 K07477 0.4142857142857143 0.037037037037037 K07477; translin 126.0 160.0 0.0 1.0 1.0 J 147.0 13.0 1.0 1.0 COG2178 Predicted_RNA-_or_ssDNA-binding_protein,_translin_family 160.0 0.91875 0.08125 0.673562398125401 0.840182650617551 0.756872524371476 0.16662025249215 0 1 0 1 K07478 0.0142857142857142 0.8490028490028491 ycaJ; putative ATPase 285.0 304.0 296.0 4.0 0.952978056426332 L 6.0 313.0 4.0 0.949843260188088 COG2256 Replication-associated_recombination_protein_RarA_(DNA-dependent_ATPase) RarA 319.0 0.018808777429467 0.9811912225705328 0.358017839300294 0.905792211816283 0.6319050255582885 0.5477743725159889 0 0 0 0 K07479 0.0028571428571428 0.037037037037037 yrdD; putative DNA topoisomerase 97.0 12.0 8.0 2.0 0.75 L 1.0 15.0 3.0 0.625 COG0551 DNA_topoisomerase_I,_ssDNA-binding_Zn-finger_and_Zn-ribbon_domains YrdD 16.0 0.0625 0.9375 0.646905682719411 0.134907554987312 0.3909066188533615 0.511998127732099 0 0 0 1 K07480 0.0342857142857142 0.0512820512820512 insB; insertion element IS1 protein InsB 53.0 105.0 0.0 1.0 1.0 L 57.0 38.0 2.0 0.857142857142857 COG1662 Transposase_and_inactivated_derivatives,_IS1_family InsB 95.0 0.6 0.4 0.0022978569082709 0.0034359010744796 0.0028668789913752 0.0011380441662087 0 0 0 0 K07481 0.0485714285714285 0.1082621082621082 K07481; transposase, IS5 family 62.0 278.0 0.0 1.0 1.0 L 76.0 160.0 1.0 1.0 COG3039 Transposase_and_inactivated_derivatives,_IS5_family IS5 236.0 0.3220338983050847 0.6779661016949152 0.0006711916100568 0.0017723585488254 0.0012217750794411 0.0011011669387686 0 0 0 0 K07482 0.0 0.0 K07482; transposase, IS30 family 54.0 0.0 1.0 1.0 L 0.0 0.0 1.0 1.0 COG2826 Transposase_and_inactivated_derivatives,_IS30_family Tra8 0.0 0 0 0 0 K07483 0.0114285714285714 0.3732193732193732 K07483; transposase 5.0 516.0 510.0 2.0 0.988505747126437 L 5.0 471.0 5.0 0.906130268199234 COG2963 Transposase_InsE_and_inactivated_derivatives InsE 476.0 0.0105042016806722 0.9894957983193278 0.0067400652795118 0.0162405973795164 0.0114903313295141 0.0095005321000046 0 0 0 0 K07484 0.0 0.0 K07484; transposase 522.0 486.0 7.0 0.904679376083189 L 0.0 0.0 11.0 0.522998296422487 COG3436 Transposase 0.0 0 0 0 0 K07485 0.0 0.0 K07485; transposase 174.0 0.0 1.0 1.0 L 0.0 0.0 1.0 1.0 COG3464 Transposase 0.0 0 0 0 0 K07486 0.0 0.0 K07486; transposase 240.0 231.0 2.0 0.963855421686747 L 0.0 0.0 2.0 0.959839357429719 COG3547 Transposase 0.0 0 0 0 0 K07487 0.0 0.0 K07487; transposase 80.0 0.0 1.0 1.0 L 0.0 0.0 2.0 0.674698795180723 COG3666 Transposase,_IS1182_family 0.0 0 0 0 0 K07488 0.0 0.0 K07488; transposase 17.0 0.0 1.0 1.0 L 0.0 0.0 3.0 0.647058823529412 COG3676 Transposase_and_inactivated_derivatives 0.0 0 0 0 0 K07489 0.0628571428571428 0.0028490028490028 K07489; transposase 63.0 86.0 0.0 1.0 1.0 L 75.0 3.0 2.0 0.872093023255814 COG3677 Transposase_InsA InsA 78.0 0.9615384615384616 0.0384615384615384 0.0020665765660605 0.0019295583278719 0.0019980674469662 0.0001370182381886 0 0 0 0 K07490 0.0 0.0056980056980056 feoC; ferrous iron transport protein C 76.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 2E630 2.0 0.0 1.0 0 0 0 0 K07491 0.2371428571428571 0.3988603988603988 rayT; REP-associated tyrosine transposase 6.0 653.0 651.0 2.0 0.996946564885496 L 179.0 429.0 3.0 0.986259541984733 COG1943 REP_element-mobilizing_transposase_RayT RAYT 608.0 0.2944078947368421 0.7055921052631579 0.0159151439711906 0.094478280264561 0.0551967121178758 0.0785631362933703 0 0 0 0 K07492 0.0 0.0 K07492; putative transposase 110.0 109.0 2.0 0.990990990990991 L 0.0 0.0 5.0 0.954954954954955 COG3293 Transposase 0.0 0 0 0 0 K07493 0.0 0.0 K07493; putative transposase 173.0 172.0 2.0 0.994252873563218 L 0.0 0.0 2.0 0.994252873563219 COG3328 Transposase_(or_an_inactivated_derivative) IS285 0.0 0 0 0 0 K07494 0.0885714285714285 0.094017094017094 K07494; putative transposase 20.0 293.0 290.0 2.0 0.989864864864865 L 98.0 153.0 2.0 0.959459459459459 COG3335 Transposase 251.0 0.3904382470119522 0.6095617529880478 3.6372230709919697e-12 0.0060205963458513 0.0030102981747442 0.006020596342214 0 0 0 0 K07495 0.0 0.0 K07495; putative transposase 268.0 0.0 1.0 1.0 L 0.0 0.0 4.0 0.964028776978417 COG3385 IS4_transposase_InsG InsG 0.0 0 0 0 0 K07496 0.0 0.0 K07496; putative transposase 1846.0 1828.0 2.0 0.990343347639485 L 0.0 0.0 3.0 0.987124463519313 COG0675 Transposase InsQ 0.0 0 0 0 0 K07497 0.0 0.0 K07497; putative transposase 1339.0 0.0 1.0 1.0 L 0.0 0.0 7.0 0.806691449814126 COG2801 Transposase_InsO_and_inactivated_derivatives Tra5 0.0 0 0 0 0 K07498 0.14 0.0826210826210826 K07498; putative transposase 48.0 224.0 211.0 3.0 0.933333333333333 L 142.0 100.0 2.0 0.934959349593496 COG3316 Transposase_(or_an_inactivated_derivative),_DDE_domain Rve 242.0 0.5867768595041323 0.4132231404958678 0.0228942141127864 0.0050239399403277 0.013959077026557 0.0178702741724587 0 0 0 0 K07499 0.0 0.0 K07499; putative transposase 197.0 194.0 2.0 0.985 L 0.0 0.0 2.0 0.565 COG3335 Transposase 0.0 0 0 0 0 K07500 0.0657142857142857 0.0 K07500; DNA endonuclease 97.0 35.0 0.0 1.0 1.0 L 35.0 0.0 1.0 1.0 COG3780 DNA_endonuclease_related_to_intein-encoded_endonucleases 35.0 1.0 0.0 0.0059064057172734 0.0115963541720309 0.0087513799446521 0.0056899484547574 0 0 0 0 K07501 0.0285714285714285 0.1452991452991453 K07501; 3'-5' exonuclease 91.0 57.0 0.0 1.0 1.0 L 10.0 52.0 3.0 0.758064516129032 COG3298 Predicted_3'-5'_exonuclease_related_to_the_exonuclease_domain_of_PolB 62.0 0.1612903225806451 0.8387096774193549 0.057126135253101 0.560199633239777 0.3086628842464389 0.503073497986676 0 0 0 0 K07502 0.3428571428571428 0.1937321937321937 yprB; uncharacterized protein 72.0 184.0 174.0 3.0 0.934010152284264 L 125.0 72.0 5.0 0.878172588832487 COG3359 Uncharacterized_conserved_protein_YprB,_contains_RNaseH-like_and_TPR_domains YprB 197.0 0.6345177664974619 0.365482233502538 0.404520839548099 0.109013909775422 0.2567673746617605 0.295506929772677 0 0 0 0 K07503 0.4028571428571428 0.0854700854700854 nucS; endonuclease [EC:3.1.-.-] 135.0 180.0 179.0 3.0 0.989010989010989 L 152.0 30.0 3.0 0.978021978021978 COG1637 Endonuclease_NucS,_RecB_family NucS 182.0 0.8351648351648352 0.1648351648351648 0.883927830081731 0.893702163397182 0.8888149967394565 0.0097743333154509 1 1 1 1 K07504 0.0771428571428571 0.1225071225071225 K07504; predicted type IV restriction endonuclease 81.0 47.0 27.0 4.0 0.552941176470588 V 33.0 51.0 2.0 0.541176470588235 COG2810 Predicted_type_IV_restriction_endonuclease 84.0 0.3928571428571428 0.6071428571428571 0.13202375798575 0.903577115648043 0.5178004368168965 0.771553357662293 0 0 0 0 K07505 0.0 0.0284900284900284 repA; regulatory protein RepA 205.0 10.0 0.0 1.0 1.0 L 0.0 10.0 2.0 0.9 COG3598 RecA-family_ATPase RepA 10.0 0.0 1.0 0.154591459147017 0.867615657752495 0.5111035584497561 0.713024198605478 0 0 0 0 K07506 0.0 0.1424501424501424 K07506; AraC family transcriptional regulator 65.0 118.0 117.0 5.0 0.967213114754098 K 0.0 124.0 7.0 0.516393442622951 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 124.0 0.0 1.0 0.0035715847397755 0.0111179714538932 0.0073447780968343 0.0075463867141176 0 0 0 0 K07507 0.0685714285714285 0.4387464387464387 mgtC; putative Mg2+ transporter-C (MgtC) family protein 75.0 196.0 183.0 3.0 0.92018779342723 S 24.0 189.0 5.0 0.924882629107981 COG1285 Magnesium_uptake_protein_YhiD/SapB,_involved_in_acid_resistance SapB 213.0 0.1126760563380281 0.8873239436619719 0.0907169407995752 0.480584388489203 0.2856506646443891 0.3898674476896278 0 0 0 0 K07508 0.0228571428571428 0.0227920227920227 ACAA2; acetyl-CoA acyltransferase 2 [EC:2.3.1.16] path:map00062,path:map00071,path:map00280,path:map01100,path:map01110,path:map01212 Fatty acid elongation,Fatty acid degradation,Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism 389.0 17.0 0.0 1.0 1.0 I 8.0 9.0 1.0 1.0 COG0183 Acetyl-CoA_acetyltransferase PaaJ 17.0 0.4705882352941176 0.5294117647058824 1.02204549139812e-12 0.0094560717661141 0.004728035883568 0.009456071765092 0 0 0 0 K07516 0.02 0.3048433048433048 fadN; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] path:map00071,path:map00362,path:map00650,path:map01100,path:map01120,path:map01200,path:map01212 Fatty acid degradation,Benzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 272.0 152.0 0.0 1.0 1.0 I 7.0 143.0 3.0 0.967105263157895 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 150.0 0.0466666666666666 0.9533333333333334 0.0013705742090636 0.0990160448727182 0.0501933095408909 0.0976454706636546 0 0 0 0 K07518 0.0 0.0142450142450142 E3.1.1.22; hydroxybutyrate-dimer hydrolase [EC:3.1.1.22] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 659.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 2BXCB 5.0 0.0 1.0 0.0677353300072599 0.134007560549212 0.1008714452782359 0.0662722305419521 0 0 0 0 K07533 0.1542857142857142 0.2307692307692307 prsA; foldase protein PrsA [EC:5.2.1.8] 28.0 121.0 75.0 3.0 0.6875 O 55.0 119.0 3.0 0.988700564971751 COG0760 Peptidyl-prolyl_isomerase,_parvulin_family SurA 174.0 0.3160919540229885 0.6839080459770115 0.193258187616732 0.181882569086757 0.1875703783517445 0.0113756185299749 0 0 0 0 K07535 0.04 0.0769230769230769 badH; 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 207.0 35.0 22.0 2.0 0.729166666666667 IQ 15.0 33.0 2.0 0.979166666666667 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 48.0 0.3125 0.6875 0.0042386951495411 0.0191881669461238 0.0117134310478324 0.0149494717965827 0 0 0 0 K07536 0.0 0.0284900284900284 badI; 2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 259.0 13.0 0.0 1.0 1.0 H 0.0 13.0 1.0 1.0 COG0447 1,4-Dihydroxy-2-naphthoyl-CoA_synthase MenB 13.0 0.0 1.0 0.0483010478849212 0.0644904113144518 0.0563957295996865 0.0161893634295305 0 0 0 0 K07537 0.0114285714285714 0.0199430199430199 dch; cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 253.0 11.0 0.0 1.0 1.0 I 4.0 7.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 11.0 0.3636363636363636 0.6363636363636364 0.0387621008357119 0.4289636608457 0.2338628808407059 0.390201560009988 0 0 0 0 K07538 0.0 0.0199430199430199 had; 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.1.1.368] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 330.0 4.0 2.0 3.0 0.571428571428571 E 0.0 7.0 2.0 0.571428571428571 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 7.0 0.0 1.0 0.0255928852655961 0.089314179487022 0.057453532376309 0.0637212942214259 0 0 0 0 K07539 0.0142857142857142 0.0199430199430199 oah; 6-oxocyclohex-1-ene-carbonyl-CoA hydrolase [EC:3.7.1.21] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 281.0 10.0 8.0 2.0 0.833333333333333 I 5.0 7.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 12.0 0.4166666666666667 0.5833333333333334 0.016620420817733 0.0237250812984941 0.0201727510581135 0.0071046604807611 0 0 0 0 K07540 0.0 0.017094017094017 E4.1.99.11; benzylsuccinate synthase [EC:4.1.99.11] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 118.0 8.0 6.0 2.0 0.8 C 0.0 10.0 2.0 0.8 COG1882 Pyruvate-formate_lyase PflD 10.0 0.0 1.0 0.0100229544951473 0.0204626224689437 0.0152427884820455 0.0104396679737963 0 0 0 0 K07543 0.0 0.0085470085470085 bbsE; benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 361.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 3.0 0.0 1.0 0 0 0 0 K07544 0.0 0.0256410256410256 bbsF; benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 187.0 17.0 0.0 1.0 1.0 C 0.0 17.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 17.0 0.0 1.0 0.0112704197192966 0.0185799816703034 0.0149252006947999 0.0073095619510067 0 0 0 0 K07545 0.0 0.0085470085470085 bbsG; (R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 201.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 3.0 0.0 1.0 0 0 0 0 K07546 0.0 0.0142450142450142 bbsH; (E)-benzylidenesuccinyl-CoA hydratase [EC:4.2.1.180] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 236.0 10.0 0.0 1.0 1.0 I 0.0 10.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 10.0 0.0 1.0 0.0001111394315253 0.012558105443147 0.0063346224373361 0.0124469660116217 0 0 0 0 K07547 0.0 0.0085470085470085 bbsC; (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsC subunit [EC:1.1.1.429] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 228.0 3.0 0.0 1.0 1.0 IQ 0.0 3.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 3.0 0.0 1.0 0 0 0 0 K07548 0.0028571428571428 0.0028490028490028 bbsD; (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsD subunit [EC:1.1.1.429] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 235.0 2.0 0.0 1.0 1.0 IQ 1.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.5 0.5 0 0 0 0 K07549 0.0085714285714285 0.0056980056980056 bbsA; benzoylsuccinyl-CoA thiolase BbsA subunit [EC:2.3.1.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 109.0 3.0 1.0 2.0 0.6 I 3.0 2.0 1.0 1.0 COG1545 Uncharacterized_OB-fold_protein,_contains_Zn-ribbon_domain 5.0 0.6 0.4 0.0462310960105357 0.208893703725823 0.1275623998681793 0.1626626077152873 0 0 0 0 K07550 0.0 0.017094017094017 bbsB; benzoylsuccinyl-CoA thiolase BbsB subunit [EC:2.3.1.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 373.0 7.0 0.0 1.0 1.0 I 0.0 7.0 1.0 1.0 COG0183 Acetyl-CoA_acetyltransferase PaaJ 7.0 0.0 1.0 0.001777819506218 0.0081142443561961 0.004946031931207 0.0063364248499781 0 0 0 0 K07552 0.0542857142857142 0.3333333333333333 bcr, tcaB; MFS transporter, DHA1 family, multidrug resistance protein 246.0 192.0 183.0 5.0 0.901408450704225 EGP 21.0 192.0 4.0 0.962441314553991 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 213.0 0.0985915492957746 0.9014084507042254 0 0 0 0 K07557 0.4771428571428571 0.0 tgtA2, arcS; archaeosine synthase alpha-subunit [EC:2.6.1.97 2.6.1.-] 150.0 200.0 0.0 1.0 1.0 J 200.0 0.0 3.0 0.875 COG1549 Archaeosine_tRNA-ribosyltransferase,_contains_uracil-DNA-glycosylase_and_PUA_domains ArcS 200.0 1.0 0.0 0.690435992966156 0.585074795262609 0.6377553941143825 0.105361197703547 0 0 0 1 K07558 0.8914285714285715 0.0 K07558, cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72] 168.0 316.0 0.0 1.0 1.0 J 316.0 0.0 1.0 1.0 COG1746 tRNA_nucleotidyltransferase_(CCA-adding_enzyme) CCA1 316.0 1.0 0.0 0.932013327200264 0.902212474224531 0.9171129007123976 0.0298008529757329 0 0 1 1 K07559 0.3028571428571429 0.1253561253561253 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-] 116.0 150.0 139.0 2.0 0.93167701863354 J 112.0 49.0 1.0 1.0 COG1859 RNA:NAD_2'-phosphotransferase,_TPT1/KptA_family KptA 161.0 0.6956521739130435 0.3043478260869565 0.538033013263781 0.945727947047625 0.741880480155703 0.407694933783844 0 1 0 1 K07560 0.0085714285714285 0.6951566951566952 dtd, DTD; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] 118.0 247.0 0.0 1.0 1.0 J 3.0 244.0 1.0 1.0 COG1490 D-aminoacyl-tRNA_deacylase Dtd 247.0 0.0121457489878542 0.9878542510121456 0.384330749726882 0.738594984699604 0.561462867213243 0.354264234972722 0 0 0 0 K07561 0.8342857142857143 0.0 DPH1, dph2; 2-(3-amino-3-carboxypropyl)histidine synthase [EC:2.5.1.108] 142.0 336.0 0.0 1.0 1.0 J 336.0 0.0 1.0 1.0 COG1736 Diphthamide_synthase_subunit_DPH2 DPH2 336.0 1.0 0.0 0.797097165440098 0.319606476531579 0.5583518209858385 0.477490688908519 0 0 1 1 K07562 0.6971428571428572 0.0 NMD3; 60S ribosomal export protein NMD3 path:map03008,path:map03013 Ribosome biogenesis in eukaryotes,Nucleocytoplasmic transport 67.0 253.0 0.0 1.0 1.0 J 252.0 0.0 2.0 0.976284584980237 COG1499 NMD_protein_affecting_ribosome_stability_and_mRNA_decay NMD3 252.0 1.0 0.0 0.82864462025181 0.210829358618024 0.519736989434917 0.617815261633786 0 0 1 1 K07565 0.1742857142857143 0.0 NIP7; 60S ribosome subunit biogenesis protein NIP7 83.0 61.0 0.0 1.0 1.0 J 61.0 0.0 1.0 1.0 COG1374 Rbosome_biogenesis_protein_Nip4,_contains_PUA_domain NIP7 61.0 1.0 0.0 0.09919492981589 0.373595737028752 0.236395333422321 0.274400807212862 0 0 0 0 K07566 0.82 0.9344729344729344 tsaC, rimN, SUA5, YRDC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] 29.0 632.0 586.0 4.0 0.925329428989751 J 299.0 389.0 5.0 0.968115942028986 COG0009 tRNA_A37_threonylcarbamoyladenosine_synthetase_subunit_TsaC/SUA5/YrdC TsaC 688.0 0.4345930232558139 0.565406976744186 0.129227004424986 0.301493473754063 0.2153602390895245 0.172266469329077 0 0 0 0 K07568 0.0485714285714285 0.7891737891737892 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] 210.0 220.0 163.0 4.0 0.681114551083591 J 17.0 306.0 1.0 1.0 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase_(queuine_synthetase) QueA 323.0 0.0526315789473684 0.9473684210526316 0.83781936379719 0.935873083239855 0.8868462235185225 0.0980537194426649 1 1 1 1 K07569 0.5 0.0 gar1; RNA-binding protein 47.0 179.0 0.0 1.0 1.0 J 179.0 0.0 1.0 1.0 COG3277 rRNA_processing_protein_Gar1 GAR1 179.0 1.0 0.0 0.112699501891387 0.0553715097441785 0.0840355058177827 0.0573279921472085 0 0 0 0 K07570 0.0 0.094017094017094 GSP13; general stress protein 13 92.0 33.0 32.0 2.0 0.970588235294117 J 0.0 34.0 1.0 1.0 COG1098 Predicted_RNA-binding_protein,_contains_ribosomal_protein_S1_(RPS1)_domain YabR 34.0 0.0 1.0 0.0243325070681224 0.0535126004864828 0.0389225537773025 0.0291800934183604 0 0 0 0 K07571 0.0 0.1538461538461538 K07571; S1 RNA binding domain protein 99.0 62.0 61.0 2.0 0.984126984126984 J 0.0 63.0 3.0 0.904761904761905 COG1098 Predicted_RNA-binding_protein,_contains_ribosomal_protein_S1_(RPS1)_domain YabR 63.0 0.0 1.0 0.846965003635724 0.428613426954685 0.6377892152952045 0.418351576681039 0 0 1 1 K07572 0.9485714285714286 0.0 K07572; putative nucleotide binding protein 129.0 336.0 0.0 1.0 1.0 J 336.0 0.0 1.0 1.0 COG1491 Predicted_nucleic_acid-binding_OB-fold_protein 336.0 1.0 0.0 0.742005046054102 0.809131701882643 0.7755683739683725 0.067126655828541 0 0 0 1 K07573 0.5485714285714286 0.0028490028490028 CSL4, EXOSC1; exosome complex component CSL4 path:map03018 RNA degradation 107.0 196.0 0.0 1.0 1.0 J 195.0 1.0 1.0 1.0 COG1096 Exosome_complex_RNA-binding_protein_Csl4,_contains_S1_and_Zn-ribbon_domains Csl4 196.0 0.9948979591836736 0.0051020408163265 0.06217398977706 0.41487931211164 0.23852665094435 0.3527053223345799 0 0 0 0 K07574 0.4828571428571429 0.2706552706552707 yhbY; RNA-binding protein 45.0 274.0 0.0 1.0 1.0 J 179.0 95.0 2.0 0.948905109489051 COG1534 RNA-binding_protein_YhbY YhbY 274.0 0.6532846715328468 0.3467153284671533 0.0887076501786155 0.165323923590864 0.1270157868847397 0.0766162734122485 0 0 0 0 K07575 0.68 0.0 MCTS, TMA20; malignant T-cell-amplified sequence 99.0 240.0 0.0 1.0 1.0 J 240.0 0.0 1.0 1.0 COG2016 Predicted_ribosome-associated_RNA-binding_protein_Tma20,_contains_PUA_domain Tma20 240.0 1.0 0.0 0.21547668061723 0.116374463437467 0.1659255720273485 0.0991022171797629 0 0 0 0 K07576 0.02 0.4188034188034188 K07576; metallo-beta-lactamase family protein 240.0 183.0 181.0 4.0 0.968253968253968 J 9.0 180.0 3.0 0.973544973544974 COG1236 RNA_processing_exonuclease,_beta-lactamase_fold,_Cft2_family YSH1 189.0 0.0476190476190476 0.9523809523809524 0.992933510776676 0.906959670540237 0.9499465906584564 0.085973840236439 1 1 1 1 K07577 0.7085714285714285 0.1481481481481481 K07577; putative mRNA 3-end processing factor 103.0 446.0 434.0 4.0 0.94692144373673 J 415.0 56.0 2.0 0.987261146496815 COG1236 RNA_processing_exonuclease,_beta-lactamase_fold,_Cft2_family YSH1 471.0 0.881104033970276 0.1188959660297239 0.87935734892395 0.792346332845516 0.8358518408847331 0.0870110160784339 1 1 1 1 K07578 0.0314285714285714 0.0028490028490028 K07578; homologs of the eukaryotic argonaute protein 449.0 12.0 0.0 1.0 1.0 J 11.0 1.0 1.0 1.0 COG1431 PIWI_domain,_catalyzes_dsRNA-guided_hydrolysis_of_ssRNA,_involved_in_RNA_silencing,_RNA_metabolism_and_antiviral_defense PIWI 12.0 0.9166666666666666 0.0833333333333333 0.204961323612619 0.366865039392063 0.285913181502341 0.1619037157794439 0 0 0 0 K07579 0.68 0.0028490028490028 K07579; putative methylase 124.0 171.0 101.0 2.0 0.70954356846473 Q 240.0 1.0 1.0 1.0 COG2263 Predicted_RNA_methylase 241.0 0.995850622406639 0.0041493775933609 0.0379157218986469 0.115959630960917 0.0769376764297819 0.0780439090622701 0 0 0 0 K07580 0.5771428571428572 0.0 K07580; Zn-ribbon RNA-binding protein 36.0 204.0 0.0 1.0 1.0 J 204.0 0.0 1.0 1.0 COG2888 Predicted_RNA-binding_protein_involved_in_translation,_contains__Zn-ribbon_domain,_DUF1610_family 204.0 1.0 0.0 0.470565442485524 0.880018645421049 0.6752920439532866 0.409453202935525 0 0 0 0 K07581 0.5742857142857143 0.0 K07581; RNA-binding protein 59.0 207.0 0.0 1.0 1.0 J 207.0 0.0 1.0 1.0 COG1325 Exosome_subunit,_RNA_binding_protein_with_dsRBD_fold 207.0 1.0 0.0 0.63882887819785 0.896277384055481 0.7675531311266655 0.257448505857631 0 0 0 1 K07583 0.7342857142857143 0.0028490028490028 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25] 238.0 263.0 0.0 1.0 1.0 J 262.0 1.0 1.0 1.0 COG1258 tRNA_U54_and_U55_pseudouridine_synthase_Pus10 Pus10 263.0 0.9961977186311788 0.0038022813688212 0.135063499262558 0.254993262869807 0.1950283810661825 0.119929763607249 0 0 0 0 K07584 0.0 0.1481481481481481 ysxB; uncharacterized protein 62.0 52.0 0.0 1.0 1.0 J 0.0 52.0 1.0 1.0 COG2868 Uncharacterized_conserved_protein_YsxB,_DUF464_family YsxB 52.0 0.0 1.0 0.0824865331151332 0.244435043204879 0.1634607881600061 0.1619485100897458 0 0 0 0 K07585 0.24 0.0 K07585; tRNA methyltransferase 173.0 84.0 0.0 1.0 1.0 J 88.0 0.0 2.0 0.954545454545455 COG2117 Predicted_subunit_of_tRNA(5-methylaminomethyl-2-thiouridylate)_methyltransferase,_contains_the_PP-loop_ATPase_domain 88.0 1.0 0.0 0.233224131624265 0.116708002157571 0.174966066890918 0.116516129466694 0 0 0 0 K07586 0.0028571428571428 0.1025641025641025 ygaC; uncharacterized protein 75.0 36.0 32.0 2.0 0.9 J 1.0 39.0 2.0 0.9 COG3557 Uncharacterized_conserved_protein_associated_with_RNAses_G_and_E,__UPF0374/DUF402_family YgaC 40.0 0.025 0.975 0.0274828072828196 0.472244114362105 0.2498634608224623 0.4447613070792854 0 0 0 0 K07587 0.2371428571428571 0.0 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27] path:map00970 Aminoacyl-tRNA biosynthesis 455.0 87.0 0.0 1.0 1.0 J 87.0 0.0 1.0 1.0 COG0016 Phenylalanyl-tRNA_synthetase_alpha_subunit PheS 87.0 1.0 0.0 0.995973316494056 0.996783234913086 0.996378275703571 0.0008099184190299 0 0 1 1 K07588 0.3657142857142857 0.4358974358974359 MMAA, argK; GTPase [EC:3.6.5.-] 170.0 322.0 316.0 2.0 0.981707317073171 E 138.0 190.0 4.0 0.963414634146341 COG1703 GTPase_of_the_G3E_family_(not_a_periplasmic_protein_kinase) ArgK 328.0 0.4207317073170731 0.5792682926829268 0.0146705937610792 0.799039043289661 0.4068548185253701 0.7843684495285819 0 0 0 0 K07589 0.0057142857142857 0.0484330484330484 folX; D-erythro-7,8-dihydroneopterin triphosphate epimerase [EC:5.1.99.7] path:map00790 Folate biosynthesis 113.0 19.0 0.0 1.0 1.0 H 2.0 17.0 1.0 1.0 COG1539 Dihydroneopterin_aldolase FolB 19.0 0.1052631578947368 0.8947368421052632 0.0344835183539882 0.266983552363155 0.1507335353585716 0.2325000340091668 0 0 0 0 K07590 0.0 0.0997150997150997 RP-L7A, rplGB; large subunit ribosomal protein L7A path:map03010 Ribosome 68.0 35.0 33.0 2.0 0.945945945945946 J 0.0 37.0 1.0 1.0 COG1358 Ribosomal_protein_L7Ae_or_related_RNA_K-turn-binding_protein Rpl7Ae 37.0 0.0 1.0 0.0517182707906908 0.712387360983063 0.3820528158868769 0.6606690901923722 0 0 0 0 K07592 0.0 0.0028490028490028 tdcA; LysR family transcriptional regulator, tdc operon transcriptional activator 312.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 1.0 0.0 1.0 0 0 0 0 K07623 0.0 0.0626780626780626 GJB4, CX30.3; gap junction beta-4 protein 384.0 18.0 14.0 2.0 0.818181818181818 S 0.0 22.0 1.0 1.0 COG0612 Predicted_Zn-dependent_peptidase,_M16_family PqqL 22.0 0.0 1.0 0.0053403367090669 0.0227241895783717 0.0140322631437193 0.0173838528693048 0 0 0 0 K07636 0.02 0.8034188034188035 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] path:map02020 Two-component system 86.0 415.0 413.0 2.0 0.995203836930456 T 12.0 405.0 9.0 0.776978417266187 COG5002 Sensor_histidine_kinase_WalK WalK 417.0 0.0287769784172661 0.9712230215827338 0.159837052558077 0.219524718661429 0.189680885609753 0.0596876661033519 0 0 0 0 K07637 0.0 0.0541310541310541 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 327.0 20.0 0.0 1.0 1.0 T 0.0 20.0 3.0 0.75 COG0642 Signal_transduction_histidine_kinase BaeS 20.0 0.0 1.0 0.0022412346236338 0.0062043095123759 0.0042227720680048 0.0039630748887421 0 0 0 0 K07638 0.0 0.1709401709401709 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 227.0 58.0 51.0 2.0 0.892307692307692 T 0.0 65.0 6.0 0.723076923076923 COG0642 Signal_transduction_histidine_kinase BaeS 65.0 0.0 1.0 0.0009893817033549 0.342896493322238 0.1719429375127964 0.3419071116188831 0 0 0 0 K07639 0.0028571428571428 0.0341880341880341 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] path:map02020 Two-component system 354.0 15.0 0.0 1.0 1.0 T 1.0 14.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 15.0 0.0666666666666666 0.9333333333333332 0.0063819836272747 0.01241584779263 0.0093989157099523 0.0060338641653553 0 0 0 0 K07640 0.0 0.0683760683760683 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 269.0 26.0 0.0 1.0 1.0 T 0.0 26.0 4.0 0.807692307692308 COG0642 Signal_transduction_histidine_kinase BaeS 26.0 0.0 1.0 0.0048176944901997 0.0106153435644991 0.0077165190273494 0.0057976490742993 0 0 0 0 K07641 0.0 0.037037037037037 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] path:map02020 Two-component system 331.0 13.0 0.0 1.0 1.0 T 0.0 13.0 3.0 0.846153846153846 COG0642 Signal_transduction_histidine_kinase BaeS 13.0 0.0 1.0 0.0143466609316519 0.0961638464041439 0.0552552536678979 0.0818171854724919 0 0 0 0 K07642 0.0 0.1623931623931624 baeS, smeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] path:map02020 Two-component system 215.0 85.0 0.0 1.0 1.0 T 0.0 85.0 6.0 0.341176470588235 COG0642 Signal_transduction_histidine_kinase BaeS 85.0 0.0 1.0 0.0017623610563302 0.338379990901215 0.1700711759787726 0.3366176298448848 0 0 0 0 K07643 0.0 0.0113960113960113 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 326.0 4.0 0.0 1.0 1.0 T 0.0 4.0 3.0 0.5 COG0642 Signal_transduction_histidine_kinase BaeS 4.0 0.0 1.0 0.0153722992591446 0.031336685044387 0.0233544921517658 0.0159643857852423 0 0 0 0 K07644 0.0 0.0883190883190883 cusS, copS, silS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] path:map02020 Two-component system 263.0 45.0 0.0 1.0 1.0 T 0.0 45.0 3.0 0.755555555555556 COG0642 Signal_transduction_histidine_kinase BaeS 45.0 0.0 1.0 0.0018522871617261 0.0596364049327214 0.0307443460472237 0.0577841177709953 0 0 0 0 K07645 0.0 0.0769230769230769 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 270.0 35.0 0.0 1.0 1.0 T 0.0 35.0 3.0 0.857142857142857 COG0642 Signal_transduction_histidine_kinase BaeS 35.0 0.0 1.0 0.006374770391063 0.0242969047597367 0.0153358375753998 0.0179221343686737 0 0 0 0 K07646 0.0 0.0 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] path:map02020 Two-component system 177.0 172.0 2.0 0.972527472527472 T 0.0 0.0 5.0 0.884615384615385 COG0642 Signal_transduction_histidine_kinase BaeS 0.0 0 0 0 0 K07647 0.0 0.0313390313390313 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3] path:map02020 Two-component system 71.0 15.0 0.0 1.0 1.0 T 0.0 15.0 5.0 0.533333333333333 COG0642 Signal_transduction_histidine_kinase BaeS 15.0 0.0 1.0 0.007186842487013 0.0166287003381519 0.0119077714125824 0.0094418578511388 0 0 0 0 K07648 0.0028571428571428 0.0313390313390313 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 123.0 12.0 0.0 1.0 1.0 T 1.0 11.0 3.0 0.583333333333333 COG0642 Signal_transduction_histidine_kinase BaeS 12.0 0.0833333333333333 0.9166666666666666 0.0102036283974001 0.0342202915993359 0.022211959998368 0.0240166632019358 0 0 0 0 K07649 0.0 0.0769230769230769 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] path:map02020 Two-component system 295.0 42.0 0.0 1.0 1.0 T 0.0 42.0 6.0 0.714285714285714 COG0642 Signal_transduction_histidine_kinase BaeS 42.0 0.0 1.0 0.0025992574353658 0.0069862647764548 0.0047927611059103 0.0043870073410889 0 0 0 0 K07650 0.0 0.0284900284900284 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3] path:map02020 Two-component system 396.0 10.0 0.0 1.0 1.0 T 0.0 10.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 10.0 0.0 1.0 0.0046921282925056 0.0090060722974241 0.0068491002949648 0.0043139440049185 0 0 0 0 K07651 0.0028571428571428 0.0769230769230769 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3] path:map02020 Two-component system 304.0 34.0 0.0 1.0 1.0 T 1.0 33.0 1.0 1.0 COG5002 Sensor_histidine_kinase_WalK WalK 34.0 0.0294117647058823 0.9705882352941176 0.0048387657369536 0.919728891615735 0.4622838286763443 0.9148901258787814 0 0 0 0 K07652 0.0428571428571428 0.1139601139601139 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] path:map02020 Two-component system 202.0 67.0 64.0 2.0 0.957142857142857 T 19.0 51.0 4.0 0.7 COG5002 Sensor_histidine_kinase_WalK WalK 70.0 0.2714285714285714 0.7285714285714285 0.0196446808694689 0.0547009769432069 0.0371728289063379 0.035056296073738 0 0 0 0 K07653 0.0028571428571428 0.0569800569800569 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3] path:map02020 Two-component system 331.0 25.0 0.0 1.0 1.0 T 1.0 24.0 3.0 0.92 COG0642 Signal_transduction_histidine_kinase BaeS 25.0 0.04 0.96 0.0050022878225237 0.0765010190768387 0.0407516534496812 0.071498731254315 0 0 0 0 K07654 0.0028571428571428 0.0797720797720797 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3] path:map02020 Two-component system 310.0 41.0 40.0 2.0 0.976190476190476 T 1.0 41.0 5.0 0.404761904761905 COG5002 Sensor_histidine_kinase_WalK WalK 42.0 0.0238095238095238 0.9761904761904762 0.0017580939490574 0.0027407728011572 0.0022494333751072 0.0009826788520997 0 0 0 0 K07655 0.0 0.0085470085470085 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3] path:map02020 Two-component system 418.0 4.0 0.0 1.0 1.0 T 0.0 4.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 4.0 0.0 1.0 3.64766489751949e-06 0.0001802054026424 9.192653376995976e-05 0.0001765577377448 0 0 0 0 K07656 0.0 0.0028490028490028 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3] path:map02020 Two-component system 499.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 1.0 0.0 1.0 0 0 0 0 K07657 0.0171428571428571 0.4985754985754986 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB path:map02020 Two-component system 74.0 112.0 21.0 3.0 0.504504504504504 K 6.0 214.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 220.0 0.0272727272727272 0.9727272727272728 0.0108419277858573 0.973072137221961 0.4919570325039091 0.9622302094361036 0 0 0 0 K07658 0.0628571428571428 0.3817663817663818 phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP path:map02020 Two-component system 65.0 125.0 33.0 3.0 0.534188034188034 T 29.0 204.0 2.0 0.948717948717949 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 233.0 0.1244635193133047 0.8755364806866953 0.175769282984482 0.792473336807278 0.48412130989588 0.616704053822796 0 0 0 0 K07659 0.0028571428571428 0.1538461538461538 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 185.0 42.0 16.0 3.0 0.575342465753425 T 1.0 72.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 73.0 0.0136986301369863 0.9863013698630136 0.0009637273365562 0.0045887453944087 0.0027762363654824 0.0036250180578525 0 0 0 0 K07660 0.0 0.0541310541310541 phoP; two-component system, OmpR family, response regulator PhoP path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 217.0 9.0 1.0 3.0 0.473684210526316 T 0.0 19.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 19.0 0.0 1.0 0.0019628211374256 0.004627040234328 0.0032949306858768 0.0026642190969024 0 0 0 0 K07661 0.0 0.0398860398860398 rstA; two-component system, OmpR family, response regulator RstA path:map02020 Two-component system 211.0 12.0 6.0 2.0 0.666666666666667 K 0.0 18.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 18.0 0.0 1.0 0.0081354761253921 0.0315848863865947 0.0198601812559934 0.0234494102612025 0 0 0 0 K07662 0.0257142857142857 0.0883190883190883 cpxR; two-component system, OmpR family, response regulator CpxR path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 97.0 28.0 11.0 3.0 0.583333333333333 K 11.0 37.0 2.0 0.75 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 48.0 0.2291666666666666 0.7708333333333334 0.0080072257621827 0.0129540661958299 0.0104806459790063 0.0049468404336471 0 0 0 0 K07663 0.0 0.0427350427350427 creB; two-component system, OmpR family, catabolic regulation response regulator CreB path:map02020 Two-component system 208.0 10.0 5.0 2.0 0.666666666666667 K 0.0 15.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 15.0 0.0 1.0 0.0189969242602839 0.0466719128301395 0.0328344185452117 0.0276749885698556 0 0 0 0 K07664 0.0 0.0626780626780626 baeR, smeR; two-component system, OmpR family, response regulator BaeR path:map02020 Two-component system 192.0 18.0 13.0 2.0 0.782608695652174 K 0.0 23.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 23.0 0.0 1.0 0.0180500925599359 0.293324096408871 0.1556870944844034 0.2752740038489351 0 0 0 0 K07665 0.0028571428571428 0.1566951566951566 cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR path:map02020 Two-component system 190.0 36.0 1.0 3.0 0.444444444444444 T 1.0 80.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 81.0 0.0123456790123456 0.9876543209876544 0.0160892626044515 0.624817081981025 0.3204531722927383 0.6087278193765735 0 0 0 0 K07666 0.0 0.0911680911680911 qseB; two-component system, OmpR family, response regulator QseB path:map02020,path:map02024 Two-component system,Quorum sensing 191.0 23.0 1.0 3.0 0.5 K 0.0 46.0 2.0 0.978260869565217 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 46.0 0.0 1.0 0.0071676643687133 0.0219776932751178 0.0145726788219155 0.0148100289064045 0 0 0 0 K07667 0.0314285714285714 0.2849002849002849 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE path:map02020,path:map02024 Two-component system,Quorum sensing 109.0 80.0 8.0 3.0 0.479041916167665 K 13.0 154.0 2.0 0.910179640718563 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 167.0 0.0778443113772455 0.9221556886227544 0.016910198829509 0.79174126557245 0.4043257322009794 0.774831066742941 0 0 0 0 K07668 0.0885714285714285 0.2336182336182336 vicR; two-component system, OmpR family, response regulator VicR path:map02020 Two-component system 69.0 120.0 53.0 3.0 0.6 T 59.0 141.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 200.0 0.295 0.705 0.53182995047707 0.956529719721162 0.744179835099116 0.4246997692440919 0 1 0 1 K07669 0.08 0.131054131054131 mprA; two-component system, OmpR family, response regulator MprA path:map02020 Two-component system 85.0 77.0 48.0 3.0 0.719626168224299 T 46.0 60.0 2.0 0.94392523364486 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 106.0 0.4339622641509434 0.5660377358490566 0.0012665144127719 0.0769788984328992 0.0391227064228355 0.0757123840201273 0 0 0 0 K07670 0.0 0.0911680911680911 mtrA; two-component system, OmpR family, response regulator MtrA path:map02020 Two-component system 214.0 24.0 15.0 3.0 0.666666666666667 T 0.0 36.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 36.0 0.0 1.0 0.0005413506574885 0.0016861356820875 0.001113743169788 0.001144785024599 0 0 0 0 K07671 0.0 0.0142450142450142 prrA; two-component system, OmpR family, response regulator PrrA path:map02020 Two-component system 217.0 3.0 1.0 2.0 0.6 T 0.0 5.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 5.0 0.0 1.0 0.0152939537690274 0.0557688407994141 0.0355313972842207 0.0404748870303866 0 0 0 0 K07672 0.0 0.0626780626780626 trcR; two-component system, OmpR family, response regulator TrcR path:map02020 Two-component system 198.0 22.0 17.0 3.0 0.758620689655172 T 0.0 29.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 29.0 0.0 1.0 0.0033408049266373 0.0119435908015981 0.0076421978641177 0.0086027858749608 0 0 0 0 K07673 0.0 0.0541310541310541 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] path:map02020 Two-component system 218.0 26.0 0.0 1.0 1.0 T 0.0 26.0 7.0 0.576923076923077 COG3850 Signal_transduction_histidine_kinase_NarQ,_nitrate/nitrite-specific NarQ 26.0 0.0 1.0 0.0041922765585583 0.0146867674215273 0.0094395219900428 0.010494490862969 0 0 0 0 K07674 0.0 0.0113960113960113 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] path:map02020 Two-component system 328.0 5.0 0.0 1.0 1.0 T 0.0 5.0 1.0 1.0 COG3850 Signal_transduction_histidine_kinase_NarQ,_nitrate/nitrite-specific NarQ 5.0 0.0 1.0 0.0035463868782216 0.0088076164978142 0.0061770016880179 0.0052612296195926 0 0 0 0 K07675 0.0057142857142857 0.1452991452991453 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] path:map02020 Two-component system 85.0 66.0 64.0 3.0 0.956521739130435 T 2.0 67.0 17.0 0.391304347826087 COG4585 Signal_transduction_histidine_kinase_ComP ComP 69.0 0.0289855072463768 0.9710144927536232 0.0006925420497143 0.0064859223071486 0.0035892321784314 0.0057933802574342 0 0 0 0 K07676 0.0 0.0284900284900284 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3] path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 228.0 10.0 0.0 1.0 1.0 T 0.0 10.0 4.0 0.5 COG0642 Signal_transduction_histidine_kinase BaeS 10.0 0.0 1.0 0.0202960947630096 0.0525013474255803 0.0363987210942949 0.0322052526625706 0 0 0 0 K07677 0.0028571428571428 0.0512820512820512 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 75.0 23.0 0.0 1.0 1.0 T 1.0 22.0 4.0 0.608695652173913 COG0642 Signal_transduction_histidine_kinase BaeS 23.0 0.0434782608695652 0.9565217391304348 0.0088888582505193 0.0203695517289234 0.0146292049897213 0.0114806934784041 0 0 0 0 K07678 0.0085714285714285 0.0968660968660968 barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] path:map02020,path:map02025,path:map02026,path:map05111 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 195.0 59.0 0.0 1.0 1.0 T 3.0 56.0 9.0 0.542372881355932 COG0642 Signal_transduction_histidine_kinase BaeS 59.0 0.0508474576271186 0.9491525423728814 0.0012848073354104 0.0047393169172911 0.0030120621263507 0.0034545095818807 0 0 0 0 K07679 0.0057142857142857 0.0911680911680911 evgS, bvgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] path:map02020,path:map05133 Two-component system,Pertussis 47.0 43.0 42.0 2.0 0.977272727272727 T 2.0 42.0 7.0 0.454545454545455 COG0642 Signal_transduction_histidine_kinase BaeS 44.0 0.0454545454545454 0.9545454545454546 0.0140439335526847 0.265283575989286 0.1396637547709853 0.2512396424366013 0 0 0 0 K07680 0.0 0.0313390313390313 comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 212.0 8.0 5.0 3.0 0.666666666666667 T 0.0 12.0 4.0 0.666666666666667 COG4585 Signal_transduction_histidine_kinase_ComP ComP 12.0 0.0 1.0 0.0201122222749951 0.251046843252277 0.135579532763636 0.2309346209772819 0 0 0 0 K07681 0.0 0.037037037037037 vraS; two-component system, NarL family, vancomycin resistance sensor histidine kinase VraS [EC:2.7.13.3] path:map02020 Two-component system 265.0 14.0 0.0 1.0 1.0 T 0.0 14.0 1.0 1.0 COG4585 Signal_transduction_histidine_kinase_ComP ComP 14.0 0.0 1.0 0.0009066671030049 0.0018487928573171 0.001377729980161 0.0009421257543122 0 0 0 0 K07682 0.0 0.0256410256410256 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3] path:map02020 Two-component system 231.0 8.0 7.0 2.0 0.888888888888889 T 0.0 9.0 4.0 0.444444444444444 COG2203 GAF_domain GAF 9.0 0.0 1.0 0.0140205484315793 0.579172917471886 0.2965967329517326 0.5651523690403067 0 0 0 0 K07683 0.0 0.0341880341880341 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3] path:map02020 Two-component system 168.0 15.0 14.0 2.0 0.9375 T 0.0 16.0 6.0 0.4375 COG4585 Signal_transduction_histidine_kinase_ComP ComP 16.0 0.0 1.0 0.0075018723106782 0.0318776678121533 0.0196897700614157 0.0243757955014751 0 0 0 0 K07684 0.0028571428571428 0.1225071225071225 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL path:map02020 Two-component system 141.0 46.0 30.0 3.0 0.73015873015873 K 1.0 62.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 63.0 0.0158730158730158 0.984126984126984 0.0085385713457728 0.691889552355953 0.3502140618508629 0.6833509810101801 0 0 0 0 K07685 0.0028571428571428 0.0398860398860398 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP path:map02020 Two-component system 179.0 13.0 12.0 3.0 0.866666666666667 K 1.0 14.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 15.0 0.0666666666666666 0.9333333333333332 0.0324234305196505 0.427591871433307 0.2300076509764787 0.3951684409136565 0 0 0 0 K07686 0.0 0.0227920227920227 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA path:map02020 Two-component system 177.0 7.0 5.0 3.0 0.7 K 0.0 10.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 10.0 0.0 1.0 0.0123747296171914 0.0255232809743041 0.0189490052957477 0.0131485513571127 0 0 0 0 K07687 0.0 0.0199430199430199 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 211.0 7.0 3.0 2.0 0.636363636363636 K 0.0 11.0 3.0 0.636363636363636 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 11.0 0.0 1.0 0.0070052312305934 0.0144458704962314 0.0107255508634124 0.0074406392656379 0 0 0 0 K07688 0.0 0.017094017094017 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ path:map02020 Two-component system 191.0 5.0 4.0 2.0 0.833333333333333 K 0.0 6.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 6.0 0.0 1.0 0.0598768158693766 0.134297193529737 0.0970870046995568 0.0744203776603604 0 0 0 0 K07689 0.0 0.094017094017094 uvrY, gacA, varA; two-component system, NarL family, invasion response regulator UvrY path:map02020,path:map02025,path:map02026,path:map05111 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 138.0 34.0 27.0 3.0 0.790697674418605 K 0.0 43.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 43.0 0.0 1.0 0.0068809209882451 0.458697564764849 0.232789242876547 0.4518166437766039 0 0 0 0 K07690 0.0 0.0085470085470085 evgA, bvgA; two-component system, NarL family, response regulator EvgA path:map02020,path:map05133 Two-component system,Pertussis 203.0 3.0 2.0 2.0 0.75 K 0.0 4.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 4.0 0.0 1.0 0.0042215724721774 4.0021980343213e-09 0.0021107882371877 0.0042215684699793 0 0 0 0 K07691 0.0 0.0113960113960113 comA; two-component system, NarL family, competent response regulator ComA path:map02020,path:map02024 Two-component system,Quorum sensing 211.0 3.0 2.0 3.0 0.6 KT 0.0 5.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 5.0 0.0 1.0 0.0067617778738015 0.0200569281646924 0.0134093530192469 0.0132951502908909 0 0 0 0 K07692 0.0 0.0512820512820512 degU; two-component system, NarL family, response regulator DegU path:map02020,path:map02024 Two-component system,Quorum sensing 187.0 15.0 9.0 3.0 0.681818181818182 K 0.0 22.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 22.0 0.0 1.0 0.0043661064420294 0.0092755079512004 0.0068208071966149 0.004909401509171 0 0 0 0 K07693 0.0 0.1139601139601139 desR; two-component system, NarL family, response regulator DesR path:map02020 Two-component system 190.0 31.0 4.0 3.0 0.5 T 0.0 62.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 62.0 0.0 1.0 0.0028231118425246 0.104026790482352 0.0534249511624383 0.1012036786398274 0 0 0 0 K07694 0.0 0.0484330484330484 vraR; two-component system, NarL family, vancomycin resistance associated response regulator VraR path:map02020 Two-component system 197.0 10.0 4.0 3.0 0.588235294117647 K 0.0 17.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 17.0 0.0 1.0 0.0055469745696896 0.0079815012530546 0.0067642379113721 0.002434526683365 0 0 0 0 K07695 0.0 0.0142450142450142 devR; two-component system, NarL family, response regulator DevR path:map02020 Two-component system 210.0 3.0 1.0 2.0 0.6 K 0.0 5.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 5.0 0.0 1.0 0.0071133769869096 0.0117925353434035 0.0094529561651565 0.0046791583564939 0 0 0 0 K07696 0.0 0.0398860398860398 nreC; two-component system, NarL family, response regulator NreC path:map02020 Two-component system 204.0 8.0 1.0 2.0 0.533333333333333 T 0.0 15.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 15.0 0.0 1.0 0.0104917716330586 0.0180328332741627 0.0142623024536106 0.0075410616411041 0 0 0 0 K07697 0.0 0.0199430199430199 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3] path:map02020 Two-component system 259.0 9.0 0.0 1.0 1.0 T 0.0 9.0 3.0 0.444444444444444 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 9.0 0.0 1.0 0.0087938519059528 0.0235368113196119 0.0161653316127823 0.0147429594136591 0 0 0 0 K07698 0.0 0.017094017094017 kinC; two-component system, sporulation sensor kinase C [EC:2.7.13.3] path:map02020 Two-component system 353.0 6.0 0.0 1.0 1.0 T 0.0 6.0 2.0 0.833333333333333 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 6.0 0.0 1.0 0.0031817187227289 0.0061204717239107 0.0046510952233198 0.0029387530011818 0 0 0 0 K07699 0.0 0.094017094017094 spo0A; two-component system, response regulator, stage 0 sporulation protein A path:map02020,path:map02024 Two-component system,Quorum sensing 218.0 19.0 11.0 4.0 0.487179487179487 KT 0.0 39.0 3.0 0.58974358974359 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 39.0 0.0 1.0 0.0013418695822878 0.0147901054276466 0.0080659875049672 0.0134482358453588 0 0 0 0 K07700 0.0 0.0113960113960113 dpiB, citA; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] path:map02020 Two-component system 467.0 5.0 0.0 1.0 1.0 T 0.0 5.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 5.0 0.0 1.0 0.0183960575837357 0.0445075425945087 0.0314518000891222 0.026111485010773 0 0 0 0 K07701 0.0 0.017094017094017 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3] path:map02020 Two-component system 516.0 7.0 0.0 1.0 1.0 T 0.0 7.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 7.0 0.0 1.0 0.0096293495774418 0.022303235896666 0.0159662927370539 0.0126738863192242 0 0 0 0 K07702 0.0 0.0085470085470085 dpiA, citB; two-component system, CitB family, response regulator CitB path:map02020 Two-component system 223.0 2.0 1.0 2.0 0.666666666666667 KT 0.0 3.0 1.0 1.0 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 3.0 0.0 1.0 0 0 0 0 K07703 0.0 0.0142450142450142 dcuR; two-component system, CitB family, response regulator DcuR path:map02020 Two-component system 224.0 4.0 2.0 2.0 0.666666666666667 KT 0.0 6.0 1.0 1.0 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 6.0 0.0 1.0 0.0098868072073859 0.0199515865316319 0.0149191968695088 0.010064779324246 0 0 0 0 K07704 0.0 0.1025641025641025 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3] path:map02020 Two-component system 371.0 43.0 0.0 1.0 1.0 T 0.0 43.0 1.0 1.0 COG3275 Sensor_histidine_kinase,_LytS/YehU_family LytS 43.0 0.0 1.0 0.534151295278018 0.636358928610036 0.585255111944027 0.1022076333320179 0 0 0 1 K07705 0.0 0.1566951566951566 lytT, lytR; two-component system, LytTR family, response regulator LytT path:map02020 Two-component system 128.0 31.0 0.0 5.0 0.418918918918919 K 0.0 74.0 2.0 0.918918918918919 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 74.0 0.0 1.0 0.0071240683680335 0.508771299517982 0.2579476839430077 0.5016472311499485 0 0 0 0 K07706 0.0 0.0484330484330484 agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 153.0 31.0 0.0 1.0 1.0 T 0.0 31.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 31.0 0.0 1.0 0.0009728549166141 0.0040926909056874 0.0025327729111507 0.0031198359890732 0 0 0 0 K07707 0.0 0.0227920227920227 agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA path:map02020,path:map02024 Two-component system,Quorum sensing 217.0 8.0 4.0 2.0 0.666666666666667 K 0.0 12.0 1.0 1.0 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 12.0 0.0 1.0 0.0043091291366454 0.0087089913148945 0.0065090602257699 0.0043998621782491 0 0 0 0 K07708 0.0028571428571428 0.2222222222222222 glnL, ntrB; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] path:map02020 Two-component system 179.0 86.0 84.0 3.0 0.966292134831461 T 1.0 88.0 6.0 0.853932584269663 COG3852 Signal_transduction_histidine_kinase_NtrB,_nitrogen_specific NtrB 89.0 0.0112359550561797 0.9887640449438202 0.0011098914178449 0.0046863895908159 0.0028981405043304 0.0035764981729709 0 0 0 0 K07709 0.0428571428571428 0.188034188034188 zraS, hydH; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] path:map02020 Two-component system 74.0 146.0 145.0 2.0 0.993197278911565 T 41.0 103.0 13.0 0.292517006802721 COG0642 Signal_transduction_histidine_kinase BaeS 144.0 0.2847222222222222 0.7152777777777778 0.0025360067006325 0.0142978470344019 0.0084169268675172 0.0117618403337694 0 0 0 0 K07710 0.0028571428571428 0.1396011396011396 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3] path:map02020 Two-component system 166.0 69.0 0.0 1.0 1.0 T 1.0 68.0 8.0 0.376811594202899 COG5000 Signal_transduction_histidine_kinase_NtrY_involved_in_nitrogen_fixation_and_metabolism_regulation NtrY 69.0 0.0144927536231884 0.9855072463768116 0.0059476712467833 0.0750917648621716 0.0405197180544774 0.0691440936153883 0 0 0 0 K07711 0.0028571428571428 0.0683760683760683 glrK, qseE; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 169.0 28.0 27.0 2.0 0.96551724137931 T 1.0 28.0 5.0 0.793103448275862 COG0642 Signal_transduction_histidine_kinase BaeS 29.0 0.0344827586206896 0.9655172413793104 0.014094571806066 0.0496404217640336 0.0318674967850498 0.0355458499579676 0 0 0 0 K07712 0.0028571428571428 0.2962962962962963 glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG path:map02020 Two-component system 247.0 142.0 136.0 2.0 0.959459459459459 T 1.0 147.0 5.0 0.952702702702703 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 148.0 0.0067567567567567 0.9932432432432432 0.0028852613478941 0.0315808691766492 0.0172330652622716 0.0286956078287551 0 0 0 0 K07713 0.02 0.2535612535612536 zraR, hydG; two-component system, NtrC family, response regulator HydG path:map02020 Two-component system 212.0 218.0 214.0 3.0 0.977578475336323 T 7.0 216.0 8.0 0.94170403587444 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 223.0 0.0313901345291479 0.968609865470852 0.001365470998239 0.0136317071998833 0.0074985890990611 0.0122662362016443 0 0 0 0 K07714 0.0057142857142857 0.225071225071225 atoC; two-component system, NtrC family, response regulator AtoC path:map02020 Two-component system 261.0 198.0 194.0 2.0 0.98019801980198 T 2.0 200.0 4.0 0.975247524752475 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 202.0 0.0099009900990099 0.99009900990099 0.0163298952652706 0.104830191038577 0.0605800431519238 0.0885002957733064 0 0 0 0 K07715 0.0 0.0769230769230769 glrR, qseF; two-component system, NtrC family, response regulator GlrR path:map02020,path:map02024 Two-component system,Quorum sensing 370.0 27.0 21.0 2.0 0.818181818181818 T 0.0 33.0 3.0 0.848484848484849 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 33.0 0.0 1.0 0.0036536941605675 0.0035463753377645 0.003600034749166 0.000107318822803 0 0 0 0 K07716 0.0085714285714285 0.0968660968660968 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3] path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 103.0 71.0 70.0 5.0 0.946666666666667 T 4.0 71.0 8.0 0.706666666666667 COG0642 Signal_transduction_histidine_kinase BaeS 75.0 0.0533333333333333 0.9466666666666668 0.0075258721704705 0.0326015145847074 0.0200636933775889 0.0250756424142368 0 0 0 0 K07717 0.0 0.074074074074074 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3] path:map02020 Two-component system 191.0 40.0 0.0 1.0 1.0 T 0.0 40.0 4.0 0.525 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 40.0 0.0 1.0 0.0028824306306204 0.259460303472163 0.1311713670513916 0.2565778728415426 0 0 0 0 K07718 0.0 0.0683760683760683 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] path:map02020 Two-component system 207.0 92.0 0.0 1.0 1.0 T 0.0 92.0 1.0 1.0 COG2972 Sensor_histidine_kinase_YesM YesM 92.0 0.0 1.0 0.051434414063257 0.0024078248541717 0.0269211194587143 0.0490265892090853 0 0 0 0 K07719 0.0 0.0655270655270655 glnL; two-component system, response regulator GlnL path:map02020 Two-component system 190.0 28.0 22.0 3.0 0.8 T 0.0 35.0 8.0 0.314285714285714 COG4753 Two-component_response_regulator,_YesN/AraC_family,_consists_of_REC_and_AraC-type_DNA-binding_domains YesN 35.0 0.0 1.0 0.0019748562795275 0.0301744723089788 0.0160746642942531 0.0281996160294513 0 0 0 0 K07720 0.0028571428571428 0.1396011396011396 yesN; two-component system, response regulator YesN path:map02020 Two-component system 121.0 100.0 70.0 3.0 0.746268656716418 T 1.0 133.0 6.0 0.880597014925373 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 134.0 0.0074626865671641 0.9925373134328358 0.0022511080648226 0.0049209061437042 0.0035860071042633 0.0026697980788815 0 0 0 0 K07721 0.34 0.0256410256410256 K07721; ArsR family transcriptional regulator 78.0 139.0 138.0 2.0 0.992857142857143 K 131.0 9.0 2.0 0.814285714285714 COG1777 Predicted_transcriptional_regulator,_ArsR_family 140.0 0.9357142857142856 0.0642857142857142 0.743209782057177 0.929543838918247 0.8363768104877121 0.1863340568610699 0 1 0 1 K07722 0.66 0.1566951566951566 nikR; CopG family transcriptional regulator, nickel-responsive regulator 57.0 445.0 0.0 1.0 1.0 K 385.0 60.0 2.0 0.97752808988764 COG0864 Metal-responsive_transcriptional_regulator,_contains_CopG/Arc/MetJ_DNA-binding_domain NikR 445.0 0.8651685393258427 0.1348314606741573 0.224138524698635 0.763112105070139 0.493625314884387 0.5389735803715041 0 0 0 0 K07723 0.0 0.094017094017094 ndoAI; CopG family transcriptional regulator / antitoxin EndoAI 74.0 30.0 28.0 2.0 0.9375 K 0.0 35.0 6.0 0.857142857142857 COG0864 Metal-responsive_transcriptional_regulator,_contains_CopG/Arc/MetJ_DNA-binding_domain NikR 35.0 0.0 1.0 0.0178049838193006 0.40509393813099 0.2114494609751453 0.3872889543116893 0 0 0 0 K07724 0.0 0.0256410256410256 ner, nlp, sfsB; Ner family transcriptional regulator 80.0 6.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG3423 Predicted_transcriptional_regulator,_lambda_repressor-like_DNA-binding_domain SfsB 10.0 0.0 1.0 0.0098025448051107 0.0265619948310312 0.0181822698180709 0.0167594500259205 0 0 0 0 K07725 0.2485714285714285 0.0 csa3; CRISPR-associated protein Csa3 47.0 102.0 101.0 2.0 0.990291262135922 K 118.0 0.0 3.0 0.864406779661017 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 118.0 1.0 0.0 0.812108940090404 0.888248974901497 0.8501789574959505 0.076140034811093 0 0 1 1 K07726 0.0 0.168091168091168 K07726; putative transcriptional regulator 48.0 87.0 0.0 1.0 1.0 K 0.0 88.0 5.0 0.931818181818182 COG2944 DNA-binding_transcriptional_regulator_YiaG,_XRE-type_HTH_domain YiaG 88.0 0.0 1.0 0.01785223672904 0.0378815700413688 0.0278669033852044 0.0200293333123288 0 0 0 0 K07727 0.0114285714285714 0.245014245014245 K07727; putative transcriptional regulator 51.0 125.0 0.0 1.0 1.0 K 4.0 121.0 5.0 0.96 COG3655 DNA-binding_transcriptional_regulator,_XRE_family YozG 125.0 0.032 0.968 0.0138919825784284 0.197706317525902 0.1057991500521652 0.1838143349474736 0 0 0 0 K07728 0.5771428571428572 0.0 K07728; putative transcriptional regulator 177.0 205.0 0.0 1.0 1.0 K 205.0 0.0 1.0 1.0 COG1395 Predicted_transcriptional_regulator 205.0 1.0 0.0 0.252244352207199 0.554427557992223 0.403335955099711 0.302183205785024 0 0 0 0 K07729 0.2771428571428571 0.3190883190883191 K07729; putative transcriptional regulator 35.0 318.0 317.0 2.0 0.996865203761756 K 141.0 178.0 4.0 0.962382445141066 COG1476 DNA-binding_transcriptional_regulator,_XRE-family_HTH_domain XRE 319.0 0.4420062695924764 0.5579937304075235 0.112841969192015 0.092161010545758 0.1025014898688864 0.020680958646257 0 0 0 0 K07730 0.3028571428571429 0.0113960113960113 K07730; putative transcriptional regulator 225.0 116.0 0.0 1.0 1.0 K 111.0 5.0 1.0 1.0 COG1497 Predicted_transcriptional_regulator_MJ0558,_contains_a_CRP-type_HTH_domain MJ0558 116.0 0.956896551724138 0.043103448275862 0.484939321904566 0.708722066430157 0.5968306941673616 0.223782744525591 0 0 0 0 K07731 0.5571428571428572 0.0 K07731; putative transcriptional regulator 182.0 205.0 0.0 1.0 1.0 K 205.0 0.0 1.0 1.0 COG1709 Predicted_transcriptional_regulator,contains_XRE-type_HTH_domain 205.0 1.0 0.0 0.193796363055559 0.0466657706899985 0.1202310668727787 0.1471305923655605 0 0 0 0 K07732 0.74 0.0 rfk; riboflavin kinase, archaea type [EC:2.7.1.161] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 79.0 198.0 132.0 2.0 0.75 H 264.0 0.0 1.0 1.0 COG1339 Archaeal_CTP-dependent_riboflavin_kinase Rfk 264.0 1.0 0.0 0.424675653168835 0.440540753909638 0.4326082035392364 0.0158651007408029 0 0 0 0 K07733 0.0057142857142857 0.0854700854700854 alpA; prophage regulatory protein 54.0 44.0 0.0 1.0 1.0 K 2.0 42.0 1.0 1.0 COG3311 DNA-binding_transcriptional_regulator_AlpA AlpA 44.0 0.0454545454545454 0.9545454545454546 0.0082457555581803 0.0180609659163877 0.013153360737284 0.0098152103582074 0 0 0 0 K07734 0.0114285714285714 0.1452991452991453 paiB; transcriptional regulator 135.0 56.0 54.0 2.0 0.96551724137931 K 4.0 54.0 1.0 1.0 COG2808 Predicted_FMN-binding_regulatory_protein_PaiB PaiB 58.0 0.0689655172413793 0.9310344827586208 0.0171312753591081 0.0767501086136467 0.0469406919863774 0.0596188332545386 0 0 0 0 K07735 0.0028571428571428 0.358974358974359 algH; putative transcriptional regulator 105.0 131.0 0.0 1.0 1.0 K 1.0 130.0 1.0 1.0 COG1678 Putative_transcriptional_regulator,_AlgH/UPF0301_family AlgH 131.0 0.0076335877862595 0.9923664122137404 0.0017762330713928 0.0044144812052107 0.0030953571383017 0.0026382481338178 0 0 0 0 K07736 0.0 0.3532763532763532 carD; CarD family transcriptional regulator, regulator of rRNA transcription 109.0 133.0 0.0 1.0 1.0 K 0.0 133.0 1.0 1.0 COG1329 RNA_polymerase-interacting_regulator,_CarD/CdnL/TRCF_family CdnL 133.0 0.0 1.0 0.0020444043854167 0.338532737163996 0.1702885707747063 0.3364883327785793 0 0 0 0 K07738 0.1714285714285714 0.6780626780626781 nrdR; transcriptional repressor NrdR 111.0 294.0 0.0 1.0 1.0 K 61.0 240.0 2.0 0.976744186046512 COG1327 Transcriptional_regulator_NrdR,_contains_Zn-ribbon_and_ATP-cone_domains NrdR 301.0 0.2026578073089701 0.7973421926910299 0.230586015590465 0.830700247017045 0.530643131303755 0.60011423142658 0 0 0 0 K07739 0.7828571428571428 0.0455840455840455 ELP3, KAT9; elongator complex protein 3 (tRNA uridine(34) acetyltransferase) [EC:2.3.1.-] 366.0 273.0 249.0 2.0 0.919191919191919 K 281.0 16.0 1.0 1.0 COG1243 tRNA_U34_5-carboxymethylaminomethylation_enzyme_Elp3_(RNA_elongator_complex_protein_3),_contains_radical_SAM_and_acetyltransferase_domains ELP3 297.0 0.9461279461279462 0.0538720538720538 0.194596469309166 0.613506468166054 0.40405146873761 0.418909998856888 0 0 0 0 K07740 0.0 0.0284900284900284 rsd; regulator of sigma D 138.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG3160 Regulator_of_sigma_D Rsd 10.0 0.0 1.0 0.0010979956982866 0.0020096345701505 0.0015538151342185 0.0009116388718638 0 0 0 0 K07741 0.0 0.0683760683760683 antB; anti-repressor protein 50.0 30.0 0.0 1.0 1.0 K 0.0 30.0 3.0 0.433333333333333 COG3561 Phage_anti-repressor_protein_Ant 30.0 0.0 1.0 0.0241729290873902 0.0918745866727142 0.0580237578800522 0.067701657585324 0 0 0 0 K07742 0.0 0.3789173789173789 ylxR; uncharacterized protein 49.0 131.0 126.0 3.0 0.94927536231884 K 0.0 135.0 2.0 0.905797101449275 COG2740 Nucleoid-associated_protein_YlxR,_Predicted_RNA-binding,_DUF448_family YlxR 135.0 0.0 1.0 0.0104588073105627 0.0078073862044778 0.0091330967575202 0.0026514211060848 0 0 0 0 K07743 0.2714285714285714 0.0199430199430199 K07743; transcriptional regulator 86.0 103.0 0.0 1.0 1.0 K 96.0 7.0 1.0 1.0 COG3357 Predicted_transcriptional_regulator,_contains_HTH_and_Zn-ribbon_domains 103.0 0.9320388349514565 0.0679611650485436 0.0095428198534648 0.218807019685149 0.1141749197693069 0.2092641998316842 0 0 0 0 K07744 0.3514285714285714 0.0 K07744; transcriptional regulator 144.0 145.0 0.0 1.0 1.0 K 145.0 0.0 1.0 1.0 COG2524 Predicted_transcriptional_regulator,_contains_C-terminal_CBS_domains 145.0 1.0 0.0 0.884095202271249 0.0059289994983656 0.4450121008848073 0.8781662027728835 0 0 1 1 K07745 0.1571428571428571 0.0 K07745; transcriptional regulator 133.0 58.0 0.0 1.0 1.0 K 58.0 0.0 1.0 1.0 COG1318 Predicted_transcriptional_regulator 58.0 1.0 0.0 0.135668451165366 0.818812968163683 0.4772407096645245 0.683144516998317 0 0 0 0 K07746 0.0228571428571428 0.1452991452991453 parD1_3_4; antitoxin ParD1/3/4 39.0 123.0 119.0 3.0 0.946153846153846 K 9.0 126.0 7.0 0.91044776119403 COG3609 Transcriptional_regulator,_contains_Arc/MetJ-type_RHH_(ribbon-helix-helix)_DNA-binding_domain ParD 135.0 0.0666666666666666 0.9333333333333332 0.0040822958166132 0.0104332577099444 0.0072577767632788 0.0063509618933311 0 0 0 0 K07749 0.0628571428571428 0.1652421652421652 frc; formyl-CoA transferase [EC:2.8.3.16] 228.0 181.0 180.0 2.0 0.994505494505494 C 23.0 159.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 182.0 0.1263736263736263 0.8736263736263736 0.0094405918998534 0.02820195574928 0.0188212738245667 0.0187613638494266 0 0 0 0 K07751 0.0 0.017094017094017 pepB; PepB aminopeptidase [EC:3.4.11.23] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 419.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG0260 Leucyl_aminopeptidase PepB 6.0 0.0 1.0 1.96963011131407e-12 4.57551161832723e-08 2.287854290669181e-08 4.5753146553160994e-08 0 0 0 0 K07752 0.04 0.0569800569800569 CPD; carboxypeptidase D [EC:3.4.17.22] 55.0 29.0 12.0 4.0 0.568627450980392 E 14.0 37.0 10.0 0.450980392156863 COG2866 Murein_tripeptide_amidase_MpaA MpaA 51.0 0.2745098039215686 0.7254901960784313 0.337981728409409 0.478106129239775 0.408043928824592 0.140124400830366 0 0 0 0 K07753 0.0 0.0028490028490028 PECR; peroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38] path:map04146 Peroxisome 280.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K07755 0.2142857142857142 0.2535612535612536 AS3MT; arsenite methyltransferase [EC:2.1.1.137] path:map05208 Chemical carcinogenesis - reactive oxygen species 111.0 180.0 167.0 7.0 0.87378640776699 Q 100.0 106.0 7.0 0.703883495145631 COG0500 SAM-dependent_methyltransferase SmtA 206.0 0.4854368932038835 0.5145631067961165 0.194101748458437 0.780382184262418 0.4872419663604275 0.586280435803981 0 0 0 0 K07757 0.0028571428571428 0.0113960113960113 ybiV; sugar-phosphatase [EC:3.1.3.23] 107.0 4.0 2.0 2.0 0.666666666666667 S 1.0 5.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 6.0 0.1666666666666666 0.8333333333333334 0.022556447474217 0.0574447485043922 0.0400005979893045 0.0348883010301752 0 0 0 0 K07763 0.0028571428571428 0.0 MMP14; matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80] path:map04668,path:map04912,path:map04928 TNF signaling pathway,GnRH signaling pathway,Parathyroid hormone synthesis, secretion and action 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K07768 0.0 0.094017094017094 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3] path:map02020 Two-component system 297.0 34.0 32.0 2.0 0.944444444444444 T 0.0 36.0 2.0 0.916666666666667 COG5002 Sensor_histidine_kinase_WalK WalK 36.0 0.0 1.0 0.0018488481985079 0.195398020499728 0.0986234343491179 0.1935491723012201 0 0 0 0 K07769 0.0 0.0455840455840455 nblS, dfr, dspA, hik33; two-component system, OmpR family, sensor histidine kinase NblS [EC:2.7.13.3] path:map02020 Two-component system 596.0 16.0 0.0 1.0 1.0 T 0.0 16.0 1.0 1.0 COG5002 Sensor_histidine_kinase_WalK WalK 16.0 0.0 1.0 4.77650323187951e-22 1.04981931504676e-13 5.2490965991163157e-14 1.0498193102702569e-13 0 0 0 0 K07770 0.0 0.0341880341880341 cssR; two-component system, OmpR family, response regulator CssR path:map02020 Two-component system 209.0 9.0 4.0 2.0 0.642857142857143 T 0.0 14.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 14.0 0.0 1.0 0.0036438243821593 0.0179940019977731 0.0108189131899662 0.0143501776156138 0 0 0 0 K07771 0.0 0.0085470085470085 basR; two-component system, OmpR family, response regulator BasR path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 216.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 3.0 0.0 1.0 0 0 0 0 K07772 0.0 0.0199430199430199 torR; two-component system, OmpR family, torCAD operon response regulator TorR path:map02020 Two-component system 229.0 6.0 5.0 2.0 0.857142857142857 K 0.0 7.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 7.0 0.0 1.0 0.041840417192997 0.0976995241841388 0.0697699706885679 0.0558591069911418 0 0 0 0 K07773 0.0 0.037037037037037 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA path:map02020,path:map02026 Two-component system,Biofilm formation - Escherichia coli 115.0 7.0 2.0 3.0 0.538461538461538 T 0.0 13.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 13.0 0.0 1.0 0.0026207992794254 0.0085538096259181 0.0055873044526717 0.0059330103464927 0 0 0 0 K07774 0.0 0.0512820512820512 tctD; two-component system, OmpR family, response regulator TctD path:map02020 Two-component system 204.0 19.0 10.0 2.0 0.678571428571429 K 0.0 28.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 28.0 0.0 1.0 0.0025772695571662 0.0052646651169759 0.003920967337071 0.0026873955598097 0 0 0 0 K07775 0.0 0.094017094017094 resD; two-component system, OmpR family, response regulator ResD path:map02020 Two-component system 195.0 28.0 11.0 3.0 0.595744680851064 T 0.0 47.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 47.0 0.0 1.0 0.0012645036320617 0.796171007827174 0.3987177557296178 0.7949065041951123 0 0 0 0 K07776 0.0 0.1054131054131054 regX3; two-component system, OmpR family, response regulator RegX3 path:map02020 Two-component system 214.0 30.0 19.0 3.0 0.681818181818182 T 0.0 44.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 44.0 0.0 1.0 0.0599496538240603 0.295108990577216 0.1775293222006381 0.2351593367531557 0 0 0 0 K07777 0.0 0.1025641025641025 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3] path:map02020 Two-component system 194.0 45.0 44.0 4.0 0.9375 T 0.0 50.0 7.0 0.84 COG4585 Signal_transduction_histidine_kinase_ComP ComP 50.0 0.0 1.0 0.0410160478307745 0.886040081034129 0.4635280644324517 0.8450240332033545 0 0 0 0 K07778 0.0 0.1253561253561253 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3] path:map02020 Two-component system 181.0 65.0 64.0 2.0 0.984848484848485 T 0.0 66.0 4.0 0.893939393939394 COG4585 Signal_transduction_histidine_kinase_ComP ComP 66.0 0.0 1.0 0.003833663831967 0.202375576475495 0.103104620153731 0.198541912643528 0 0 0 0 K07780 0.0 0.0028490028490028 appY; AraC family transcriptional regulator, transcriptional regulator required for anaerobic and stationary phase induction of genes path:map02020 Two-component system 249.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K07781 0.0 0.0085470085470085 rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor path:map02020,path:map02024,path:map02026 Two-component system,Quorum sensing,Biofilm formation - Escherichia coli 176.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 3.0 0.0 1.0 0 0 0 0 K07782 0.0 0.0626780626780626 sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA path:map02020,path:map02024,path:map02026 Two-component system,Quorum sensing,Biofilm formation - Escherichia coli 86.0 29.0 28.0 2.0 0.966666666666667 K 0.0 30.0 2.0 0.933333333333333 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 30.0 0.0 1.0 0.0075600855309562 0.0131460092138866 0.0103530473724214 0.0055859236829303 0 0 0 0 K07783 0.0 0.0427350427350427 uhpC; MFS transporter, OPA family, sugar phosphate sensor protein UhpC path:map02020 Two-component system 372.0 18.0 17.0 2.0 0.947368421052632 G 0.0 19.0 1.0 1.0 COG2271 Sugar_phosphate_permease UhpC 19.0 0.0 1.0 0.0123605419568381 0.0325642238567641 0.0224623829068011 0.020203681899926 0 0 0 0 K07784 0.0 0.017094017094017 uhpT; MFS transporter, OPA family, hexose phosphate transport protein UhpT path:map02020 Two-component system 452.0 5.0 4.0 2.0 0.833333333333333 G 0.0 6.0 1.0 1.0 COG2271 Sugar_phosphate_permease UhpC 6.0 0.0 1.0 0.0337256466687515 0.0694923940863274 0.0516090203775394 0.0357667474175759 0 0 0 0 K07785 0.0028571428571428 0.0056980056980056 nrsD, nreB; MFS transporter, NRE family, putaive nickel resistance protein path:map02020 Two-component system 374.0 3.0 0.0 1.0 1.0 EGP 1.0 2.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K07786 0.0 0.0113960113960113 emrY; MFS transporter, DHA2 family, multidrug resistance protein path:map02020 Two-component system 466.0 3.0 2.0 2.0 0.75 EGP 0.0 4.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 4.0 0.0 1.0 0 0 0 0 K07787 0.0 0.2592592592592592 cusA, silA; copper/silver efflux system protein path:map02020 Two-component system 924.0 143.0 130.0 2.0 0.916666666666667 P 0.0 156.0 3.0 0.891025641025641 COG3696 Cu/Ag_efflux_pump_CusA CusA 156.0 0.0 1.0 0.108917763894455 0.335226748864464 0.2220722563794595 0.226308984970009 0 0 0 0 K07788 0.0 0.0826210826210826 mdtB; multidrug efflux pump path:map02020 Two-component system 955.0 51.0 0.0 1.0 1.0 V 0.0 51.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 51.0 0.0 1.0 0.0090751352927711 0.0252458005172208 0.0171604679049959 0.0161706652244497 0 0 0 0 K07789 0.0 0.0826210826210826 mdtC; multidrug efflux pump path:map02020 Two-component system 946.0 48.0 47.0 2.0 0.979591836734694 V 0.0 49.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 49.0 0.0 1.0 0.0045519903956539 0.0120354431951315 0.0082937167953927 0.0074834527994775 0 0 0 0 K07790 0.0 0.0227920227920227 pagO; putative membrane protein PagO path:map02020 Two-component system 288.0 8.0 0.0 1.0 1.0 EG 0.0 8.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 8.0 0.0 1.0 0.0053025447779626 0.0110734091869348 0.0081879769824487 0.0057708644089722 0 0 0 0 K07791 0.0 0.0427350427350427 dcuA; anaerobic C4-dicarboxylate transporter DcuA 420.0 15.0 13.0 3.0 0.833333333333333 S 0.0 18.0 1.0 1.0 COG2704 Anaerobic_C4-dicarboxylate_transporter DcuA 18.0 0.0 1.0 0.0111190277851302 0.0304761568697395 0.0207975923274348 0.0193571290846093 0 0 0 0 K07792 0.0 0.0484330484330484 dcuB; anaerobic C4-dicarboxylate transporter DcuB path:map02020 Two-component system 425.0 15.0 13.0 3.0 0.789473684210526 S 0.0 19.0 1.0 1.0 COG2704 Anaerobic_C4-dicarboxylate_transporter DcuA 19.0 0.0 1.0 0.0505298245214485 0.144872950922028 0.0977013877217382 0.0943431264005795 0 0 0 0 K07793 0.0485714285714285 0.2051282051282051 tctA; putative tricarboxylic transport membrane protein path:map02020 Two-component system 408.0 187.0 0.0 1.0 1.0 S 26.0 161.0 2.0 0.86096256684492 COG3333 TctA_family_transporter 187.0 0.1390374331550802 0.8609625668449198 0.128350516151432 0.047363677679757 0.0878570969155945 0.080986838471675 0 0 0 0 K07794 0.0 0.131054131054131 tctB; putative tricarboxylic transport membrane protein path:map02020 Two-component system 104.0 64.0 0.0 1.0 1.0 S 0.0 64.0 18.0 0.234375 2CQ1K 64.0 0.0 1.0 0.0149493352438148 0.0423092166993807 0.0286292759715977 0.0273598814555659 0 0 0 0 K07795 0.0 0.1481481481481481 tctC; putative tricarboxylic transport membrane protein path:map02020 Two-component system 224.0 72.0 70.0 2.0 0.972972972972973 S 0.0 74.0 1.0 1.0 COG3181 Tripartite-type_tricarboxylate_transporter,_extracytoplasmic_receptor_component_TctC TctC 74.0 0.0 1.0 0.0067502845027636 0.0444389995102255 0.0255946420064945 0.0376887150074619 0 0 0 0 K07796 0.0 0.0028490028490028 cusC, silC; outer membrane protein, copper/silver efflux system path:map02020 Two-component system 457.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 1.0 0.0 1.0 0 0 0 0 K07797 0.0 0.0056980056980056 emrK; multidrug resistance protein K path:map02020 Two-component system 383.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1566 Multidrug_resistance_efflux_pump_EmrA EmrA 3.0 0.0 1.0 0 0 0 0 K07798 0.0 0.2649572649572649 cusB, silB; membrane fusion protein, copper/silver efflux system path:map02020 Two-component system 233.0 141.0 139.0 4.0 0.965753424657534 M 0.0 146.0 3.0 0.986301369863014 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 146.0 0.0 1.0 0.0159228753295208 0.0830333801077396 0.0494781277186302 0.0671105047782188 0 0 0 0 K07799 0.0 0.1282051282051282 mdtA; membrane fusion protein, multidrug efflux system path:map02020 Two-component system 265.0 63.0 62.0 2.0 0.984375 M 0.0 64.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 64.0 0.0 1.0 0.0018578667150939 0.0045008692221581 0.003179367968626 0.0026430025070642 0 0 0 0 K07800 0.0 0.0085470085470085 agrD; AgrD protein path:map02020,path:map02024 Two-component system,Quorum sensing 39.0 0.0 3.0 3.0 0.333333333333333 2BAVM 3.0 0.0 1.0 0 0 0 0 K07803 0.0 0.0512820512820512 zraP; zinc resistance-associated protein path:map02020 Two-component system 79.0 18.0 16.0 2.0 0.9 NPTU 0.0 22.0 3.0 0.818181818181818 COG3678 Periplasmic_chaperone_Spy,_Spy/CpxP_family CpxP 22.0 0.0 1.0 0 0 0 0 K07804 0.0 0.0085470085470085 pagC; putatice virulence related protein PagC path:map02020 Two-component system 139.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 4.0 0.0 1.0 5.83199869872988e-12 0.0945253424685759 0.0472626712372039 0.0945253424627439 0 0 0 0 K07806 0.0085714285714285 0.0598290598290598 arnB, pmrH; UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87] path:map00520,path:map01100,path:map01250,path:map01503,path:map02020 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars,Cationic antimicrobial peptide (CAMP) resistance,Two-component system 329.0 18.0 13.0 3.0 0.75 E 3.0 21.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 24.0 0.125 0.875 0.0744902042353795 0.214030576077269 0.1442603901563242 0.1395403718418895 0 0 0 0 K07807 0.0 0.017094017094017 K07807; uncharacterized protein 87.0 4.0 2.0 2.0 0.666666666666667 L 0.0 6.0 1.0 1.0 COG1937 DNA-binding_transcriptional_regulator,_FrmR_family FrmR 6.0 0.0 1.0 0.0790953675038943 0.13883855111971 0.1089669593118021 0.0597431836158156 0 0 0 0 K07810 0.0 0.017094017094017 cusF; Cu(I)/Ag(I) efflux system periplasmic protein CusF path:map02020 Two-component system 103.0 3.0 0.0 2.0 0.5 S 0.0 6.0 1.0 1.0 COG5569 Periplasmic_Cu_and_Ag_efflux_protein_CusF CusF 6.0 0.0 1.0 0.0355053062218771 0.140927688329962 0.0882164972759195 0.1054223821080849 0 0 0 0 K07811 0.0 0.0056980056980056 torA; trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3] path:map00680,path:map01100,path:map01120,path:map02020 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 721.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 8.0 0.0 1.0 0.0062813888056161 0.0100171074302418 0.0081492481179289 0.0037357186246257 0 0 0 0 K07812 0.0171428571428571 0.0313390313390313 torZ; trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 556.0 26.0 0.0 1.0 1.0 C 7.0 19.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 26.0 0.2692307692307692 0.7307692307692307 0.0208098303554939 0.0513285348236335 0.0360691825895636 0.0305187044681395 0 0 0 0 K07813 0.0 0.0598290598290598 agrB; accessory gene regulator B path:map02020,path:map02024 Two-component system,Quorum sensing 107.0 38.0 37.0 2.0 0.974358974358974 KOT 0.0 39.0 2.0 0.974358974358975 COG4512 Accessory_gene_regulator_protein_AgrB AgrB 39.0 0.0 1.0 0 0 0 0 K07814 0.0171428571428571 0.2991452991452991 K07814; cyclic di-GMP phosphodiesterase [EC:3.1.4.-] 115.0 205.0 188.0 4.0 0.907079646017699 T 6.0 220.0 14.0 0.81858407079646 COG3437 Response_regulator_c-di-GMP_phosphodiesterase,_RpfG_family,_contains_REC_and_HD-GYP_domains RpfG 226.0 0.0265486725663716 0.9734513274336284 0.361764981775893 0.269661296580624 0.3157131391782585 0.092103685195269 0 0 0 0 K07816 0.0142857142857142 0.1367521367521367 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 119.0 61.0 56.0 3.0 0.91044776119403 S 5.0 60.0 3.0 0.865671641791045 COG2357 ppGpp_synthetase_catalytic_domain_(RelA/SpoT-type_nucleotidyltranferase) YjbM 65.0 0.0769230769230769 0.9230769230769232 0.156601818667951 0.171805325643647 0.164203572155799 0.015203506975696 0 0 0 0 K07821 0.0 0.0113960113960113 torY; trimethylamine-N-oxide reductase (cytochrome c), cytochrome c-type subunit TorY path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 75.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG3005 Tetraheme_cytochrome_c_subunit_NapC_of_nitrate_or_TMAO_reductase NapC 4.0 0.0 1.0 0.112328597284502 0.196779786150784 0.154554191717643 0.084451188866282 0 0 0 0 K07822 0.1314285714285714 0.0 flaC; archaeal flagellar protein FlaC 125.0 46.0 0.0 1.0 1.0 N 46.0 0.0 3.0 0.369565217391304 arCOG02963 46.0 1.0 0.0 0.0132465549014561 0.0135553560741107 0.0134009554877834 0.0003088011726545 0 0 0 0 K07823 0.0 0.0512820512820512 pcaF; 3-oxoadipyl-CoA thiolase [EC:2.3.1.174] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 398.0 26.0 0.0 1.0 1.0 I 0.0 26.0 1.0 1.0 COG0183 Acetyl-CoA_acetyltransferase PaaJ 26.0 0.0 1.0 0.003629335159212 0.017997037473984 0.0108131863165979 0.0143677023147719 0 0 0 0 K07827 0.0057142857142857 0.0 KRAS, KRAS2; GTPase KRas path:map01521,path:map01522,path:map04010,path:map04012,path:map04013,path:map04014,path:map04015,path:map04062,path:map04068,path:map04071,path:map04072,path:map04113,path:map04137,path:map04138,path:map04140,path:map04150,path:map04151,path:map04210,path:map04211,path:map04213,path:map04214,path:map04218,path:map04320,path:map04360,path:map04370,path:map04371,path:map04540,path:map04550,path:map04625,path:map04650,path:map04660,path:map04662,path:map04664,path:map04714,path:map04720,path:map04722,path:map04725,path:map04726,path:map04730,path:map04810,path:map04910,path:map04912,path:map04914,path:map04915,path:map04916,path:map04917,path:map04919,path:map04921,path:map04926,path:map04929,path:map04933,path:map04935,path:map04960,path:map05010,path:map05022,path:map05034,path:map05160,path:map05161,path:map05163,path:map05165,path:map05166,path:map05167,path:map05170,path:map05200,path:map05203,path:map05205,path:map05206,path:map05207,path:map05208,path:map05210,path:map05211,path:map05212,path:map05213,path:map05214,path:map05215,path:map05216,path:map05218,path:map05219,path:map05220,path:map05221,path:map05223,path:map05224,path:map05225,path:map05226,path:map05230,path:map05231,path:map05235,path:map05417 EGFR tyrosine kinase inhibitor resistance,Endocrine resistance,MAPK signaling pathway,ErbB signaling pathway,MAPK signaling pathway - fly,Ras signaling pathway,Rap1 signaling pathway,Chemokine signaling pathway,FoxO signaling pathway,Sphingolipid signaling pathway,Phospholipase D signaling pathway,Meiosis - yeast,Mitophagy - animal,Autophagy - yeast,Autophagy - animal,mTOR signaling pathway,PI3K-Akt signaling pathway,Apoptosis,Longevity regulating pathway,Longevity regulating pathway - multiple species,Apoptosis - fly,Cellular senescence,Dorso-ventral axis formation,Axon guidance,VEGF signaling pathway,Apelin signaling pathway,Gap junction,Signaling pathways regulating pluripotency of stem cells,C-type lectin receptor signaling pathway,Natural killer cell mediated cytotoxicity,T cell receptor signaling pathway,B cell receptor signaling pathway,Fc epsilon RI signaling pathway,Thermogenesis,Long-term potentiation,Neurotrophin signaling pathway,Cholinergic synapse,Serotonergic synapse,Long-term depression,Regulation of actin cytoskeleton,Insulin signaling pathway,GnRH signaling pathway,Progesterone-mediated oocyte maturation,Estrogen signaling pathway,Melanogenesis,Prolactin signaling pathway,Thyroid hormone signaling pathway,Oxytocin signaling pathway,Relaxin signaling pathway,GnRH secretion,AGE-RAGE signaling pathway in diabetic complications,Growth hormone synthesis, secretion and action,Aldosterone-regulated sodium reabsorption,Alzheimer disease,Pathways of neurodegeneration - multiple diseases,Alcoholism,Hepatitis C,Hepatitis B,Human cytomegalovirus infection,Human papillomavirus infection,Human T-cell leukemia virus 1 infection,Kaposi sarcoma-associated herpesvirus infection,Human immunodeficiency virus 1 infection,Pathways in cancer,Viral carcinogenesis,Proteoglycans in cancer,MicroRNAs in cancer,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species,Colorectal cancer,Renal cell carcinoma,Pancreatic cancer,Endometrial cancer,Glioma,Prostate cancer,Thyroid cancer,Melanoma,Bladder cancer,Chronic myeloid leukemia,Acute myeloid leukemia,Non-small cell lung cancer,Breast cancer,Hepatocellular carcinoma,Gastric cancer,Central carbon metabolism in cancer,Choline metabolism in cancer,PD-L1 expression and PD-1 checkpoint pathway in cancer,Lipid and atherosclerosis 91.0 1.0 0.0 2.0 0.5 G 2.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 2.0 1.0 0.0 0 0 0 0 K07836 0.0028571428571428 0.0 RAP1B; Ras-related protein Rap-1B path:map04010,path:map04014,path:map04015,path:map04024,path:map04062,path:map04510,path:map04611,path:map04670,path:map04720,path:map04722,path:map04934,path:map04972,path:map05211,path:map05417 MAPK signaling pathway,Ras signaling pathway,Rap1 signaling pathway,cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion,Platelet activation,Leukocyte transendothelial migration,Long-term potentiation,Neurotrophin signaling pathway,Cushing syndrome,Pancreatic secretion,Renal cell carcinoma,Lipid and atherosclerosis 239.0 1.0 0.0 1.0 1.0 G 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07843 0.0028571428571428 0.0 RASD1; RAS, dexamethasone-induced Ras-related protein 1 path:map04713,path:map04934 Circadian entrainment,Cushing syndrome 182.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07844 0.0028571428571428 0.0 RASD2; RASD family, member 2 182.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07862 0.0114285714285714 0.0712250712250712 sstT; serine/threonine transporter 374.0 28.0 24.0 3.0 0.848484848484848 E 4.0 29.0 3.0 0.878787878787879 COG3633 Na+/serine_and_Na+/threonine_symporter_SstT SstT 33.0 0.1212121212121212 0.8787878787878788 0.017226017400991 0.0298975591933533 0.0235617882971721 0.0126715417923622 0 0 0 0 K07870 0.0028571428571428 0.0 RHOT1, ARHT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-] path:map04137,path:map04214 Mitophagy - animal,Apoptosis - fly 270.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1798 Diphthamide_biosynthesis_methyltransferase DPH5 1.0 1.0 0.0 0 0 0 0 K07874 0.0542857142857142 0.0028490028490028 RAB1A; Ras-related protein Rab-1A path:map04140,path:map05014,path:map05022,path:map05130,path:map05134 Autophagy - animal,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases,Pathogenic Escherichia coli infection,Legionellosis 84.0 63.0 6.0 5.0 0.51219512195122 S 122.0 1.0 5.0 0.967479674796748 KOG0084 123.0 0.991869918699187 0.008130081300813 0.281032801167528 0.722753722831519 0.5018932619995234 0.4417209216639909 0 0 0 0 K07875 0.0257142857142857 0.0 RAB1B; Ras-related protein Rab-1B path:map05134 Legionellosis 165.0 7.0 2.0 2.0 0.583333333333333 S 12.0 0.0 1.0 1.0 KOG0084 12.0 1.0 0.0 0.0720285918802294 0.579723707083907 0.3258761494820681 0.5076951152036776 0 0 0 0 K07876 0.0257142857142857 0.0 RAB35, RAB1C; Ras-related protein Rab-35 path:map04144 Endocytosis 165.0 14.0 13.0 2.0 0.933333333333333 U 15.0 0.0 1.0 1.0 KOG0079 15.0 1.0 0.0 0.77888279608158 0.930122815268456 0.8545028056750179 0.151240019186876 0 0 1 1 K07877 0.0514285714285714 0.0 RAB2A; Ras-related protein Rab-2A path:map04152 AMPK signaling pathway 120.0 33.0 28.0 3.0 0.785714285714286 U 42.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 42.0 1.0 0.0 0.669468372371919 0.928650771516245 0.7990595719440821 0.2591823991443259 0 0 0 1 K07878 0.0171428571428571 0.0 RAB2B; Ras-related protein Rab-2B 166.0 4.0 2.0 2.0 0.666666666666667 F 6.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 6.0 1.0 0.0 0.70364312216009 0.922564748698901 0.8131039354294956 0.2189216265388111 0 0 0 1 K07879 0.02 0.0 RAB4A, RAB4; Ras-related protein Rab-4A path:map04144 Endocytosis 143.0 7.0 0.0 1.0 1.0 U 7.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 7.0 1.0 0.0 0.541633104863982 0.894695959678503 0.7181645322712424 0.353062854814521 0 0 0 1 K07880 0.02 0.0 RAB4B; Ras-related protein Rab-4B 143.0 7.0 0.0 1.0 1.0 U 7.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 7.0 1.0 0.0 0.541608537534958 0.894705380935703 0.7181569592353305 0.353096843400745 0 0 0 1 K07881 0.0228571428571428 0.0 RAB14; Ras-related protein Rab-14 path:map04152 AMPK signaling pathway 158.0 8.0 3.0 2.0 0.615384615384615 U 13.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 13.0 1.0 0.0 0.710688092904932 0.905847932290888 0.80826801259791 0.195159839385956 0 0 0 1 K07882 0.0142857142857142 0.0 RAB3A; Ras-related protein Rab-3A path:map04721,path:map04911 Synaptic vesicle cycle,Insulin secretion 168.0 6.0 0.0 1.0 1.0 U 6.0 0.0 2.0 0.833333333333333 KOG0093 6.0 1.0 0.0 0.337114855041477 0.758098854219442 0.5476068546304595 0.420983999177965 0 0 0 0 K07883 0.02 0.0 RAB3C; Ras-related protein Rab-3C 161.0 7.0 6.0 2.0 0.875 U 8.0 0.0 3.0 0.75 KOG0093 8.0 1.0 0.0 0.71985614815764 0.834953831058289 0.7774049896079644 0.115097682900649 0 0 0 1 K07884 0.0028571428571428 0.0 RAB3D; Ras-related protein Rab-3D path:map04972 Pancreatic secretion 195.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0093 1.0 1.0 0.0 0 0 0 0 K07885 0.0057142857142857 0.0 RAB27A; Ras-related protein Rab-27A 166.0 2.0 0.0 1.0 1.0 U 2.0 0.0 1.0 1.0 KOG0081 2.0 1.0 0.0 0 0 0 0 K07886 0.0057142857142857 0.0 RAB27B; Ras-related protein Rab-27B path:map04972 Pancreatic secretion 166.0 2.0 0.0 1.0 1.0 U 2.0 0.0 1.0 1.0 KOG0081 2.0 1.0 0.0 0 0 0 0 K07887 0.0085714285714285 0.0 RAB5A; Ras-related protein Rab-5A path:map04014,path:map04144,path:map04145,path:map04962,path:map05014,path:map05022,path:map05132,path:map05146,path:map05152 Ras signaling pathway,Endocytosis,Phagosome,Vasopressin-regulated water reabsorption,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases,Salmonella infection,Amoebiasis,Tuberculosis 122.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 KOG0092 3.0 1.0 0.0 0 0 0 0 K07888 0.0028571428571428 0.0 RAB5B; Ras-related protein Rab-5B path:map04014,path:map04144,path:map04145,path:map04962,path:map05132,path:map05146,path:map05152 Ras signaling pathway,Endocytosis,Phagosome,Vasopressin-regulated water reabsorption,Salmonella infection,Amoebiasis,Tuberculosis 173.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0092 1.0 1.0 0.0 0 0 0 0 K07889 0.0257142857142857 0.0056980056980056 RAB5C; Ras-related protein Rab-5C path:map04014,path:map04144,path:map04145,path:map04962,path:map05132,path:map05146,path:map05152 Ras signaling pathway,Endocytosis,Phagosome,Vasopressin-regulated water reabsorption,Salmonella infection,Amoebiasis,Tuberculosis 165.0 9.0 7.0 2.0 0.818181818181818 U 9.0 2.0 2.0 0.818181818181818 KOG0092 11.0 0.8181818181818182 0.1818181818181818 0.480568094160519 0.879029923649494 0.6797990089050064 0.3984618294889749 0 0 0 0 K07890 0.02 0.0 RAB21; Ras-related protein Rab-21 163.0 7.0 0.0 1.0 1.0 U 7.0 0.0 1.0 1.0 KOG0088 7.0 1.0 0.0 0.633982164854038 0.916976579365492 0.775479372109765 0.282994414511454 0 0 0 1 K07891 0.0085714285714285 0.0 RAB22; Ras-related protein Rab-22 path:map04144 Endocytosis 40.0 2.0 1.0 2.0 0.666666666666667 J 3.0 0.0 2.0 0.666666666666667 COG2126 Ribosomal_protein_L37E RPL37A 3.0 1.0 0.0 0 0 0 0 K07893 0.0285714285714285 0.0 RAB6A; Ras-related protein Rab-6A 141.0 12.0 10.0 2.0 0.857142857142857 U 14.0 0.0 1.0 1.0 KOG0094 14.0 1.0 0.0 0.570699501758014 0.820144909214402 0.695422205486208 0.249445407456388 0 0 0 1 K07897 0.0314285714285714 0.0 RAB7A; Ras-related protein Rab-7A path:map04137,path:map04138,path:map04140,path:map04144,path:map04145,path:map05132,path:map05146,path:map05152 Mitophagy - animal,Autophagy - yeast,Autophagy - animal,Endocytosis,Phagosome,Salmonella infection,Amoebiasis,Tuberculosis 124.0 19.0 15.0 2.0 0.826086956521739 U 23.0 0.0 1.0 1.0 KOG0394 23.0 1.0 0.0 0.659981616189417 0.92869625090068 0.7943389335450485 0.268714634711263 0 0 0 1 K07898 0.0085714285714285 0.0 RAB7B; Ras-related protein Rab-7B path:map04137,path:map04140,path:map04145,path:map05132,path:map05146 Mitophagy - animal,Autophagy - animal,Phagosome,Salmonella infection,Amoebiasis 163.0 2.0 1.0 2.0 0.666666666666667 U 3.0 0.0 1.0 1.0 KOG0394 3.0 1.0 0.0 0 0 0 0 K07901 0.0514285714285714 0.0028490028490028 RAB8A, MEL; Ras-related protein Rab-8A path:map04140,path:map04144,path:map04152,path:map04530,path:map04972,path:map05014,path:map05022 Autophagy - animal,Endocytosis,AMPK signaling pathway,Tight junction,Pancreatic secretion,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases 106.0 29.0 6.0 3.0 0.537037037037037 U 53.0 1.0 3.0 0.703703703703704 KOG0078 54.0 0.9814814814814816 0.0185185185185185 0.541197007363298 0.899151156245988 0.7201740818046429 0.3579541488826899 0 0 0 1 K07902 0.02 0.0 RAB8B; Ras-related protein Rab-8B path:map04530 Tight junction 166.0 7.0 6.0 2.0 0.875 U 8.0 0.0 1.0 1.0 KOG0078 8.0 1.0 0.0 0.703207971911402 0.911393198440656 0.8073005851760291 0.2081852265292539 0 0 0 1 K07903 0.0142857142857142 0.0 RAB10; Ras-related protein Rab-10 path:map04144,path:map04152 Endocytosis,AMPK signaling pathway 163.0 6.0 5.0 2.0 0.857142857142857 U 7.0 0.0 1.0 1.0 KOG0078 7.0 1.0 0.0 0.0550472909431751 0.749169871473852 0.4021085812085135 0.6941225805306769 0 0 0 0 K07904 0.0542857142857142 0.0 RAB11A; Ras-related protein Rab-11A path:map04144,path:map04961,path:map04962,path:map04972,path:map05164 Endocytosis,Endocrine and other factor-regulated calcium reabsorption,Vasopressin-regulated water reabsorption,Pancreatic secretion,Influenza A 118.0 49.0 37.0 2.0 0.80327868852459 U 61.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 61.0 1.0 0.0 0.614186362477311 0.837095697087827 0.7256410297825691 0.2229093346105161 0 0 0 1 K07905 0.0285714285714285 0.0 RAB11B; Ras-related protein Rab-11B path:map04144,path:map04152,path:map04962,path:map05164 Endocytosis,AMPK signaling pathway,Vasopressin-regulated water reabsorption,Influenza A 126.0 15.0 6.0 2.0 0.625 U 24.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 24.0 1.0 0.0 0.627016288319133 0.921714264828305 0.774365276573719 0.2946979765091719 0 0 0 1 K07907 0.0028571428571428 0.0 RAB12; Ras-related protein Rab-12 198.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0078 1.0 1.0 0.0 0 0 0 0 K07908 0.0028571428571428 0.0 RAB15; Ras-related protein Rab-15 198.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0078 1.0 1.0 0.0 0 0 0 0 K07910 0.0257142857142857 0.0 RAB18; Ras-related protein Rab-18 155.0 20.0 17.0 2.0 0.869565217391304 U 23.0 0.0 2.0 0.91304347826087 KOG0080 23.0 1.0 0.0 0.13510646724389 0.784598052148113 0.4598522596960014 0.649491584904223 0 0 0 0 K07912 0.0028571428571428 0.0 RAB24; Ras-related protein Rab-24 178.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0084 1.0 1.0 0.0 0 0 0 0 K07913 0.0114285714285714 0.0 RAB26; Ras-related protein Rab-26 90.0 6.0 0.0 1.0 1.0 U 6.0 0.0 1.0 1.0 KOG0083 6.0 1.0 0.0 0.830476704619336 0.94860752170083 0.8895421131600829 0.1181308170814939 0 0 1 1 K07914 0.0114285714285714 0.0 RAB37; Ras-related protein Rab-37 90.0 6.0 0.0 1.0 1.0 U 6.0 0.0 1.0 1.0 KOG0083 6.0 1.0 0.0 0.827951460669801 0.950344035612464 0.8891477481411325 0.122392574942663 0 0 1 1 K07915 0.0114285714285714 0.0 RAB28; Ras-related protein Rab-28 150.0 3.0 2.0 2.0 0.75 U 4.0 0.0 1.0 1.0 KOG0078 4.0 1.0 0.0 0.758865351798039 0.950862506419635 0.854863929108837 0.1919971546215959 0 0 1 1 K07916 0.0142857142857142 0.0 RAB7L1, RAB7L; Ras-related protein Rab-7L1 80.0 6.0 5.0 2.0 0.857142857142857 U 7.0 0.0 1.0 1.0 KOG4423 7.0 1.0 0.0 0.77529695155249 0.941916364503806 0.858606658028148 0.166619412951316 0 0 1 1 K07917 0.0171428571428571 0.0 RAB30; Ras-related protein Rab-30 163.0 7.0 0.0 1.0 1.0 U 7.0 0.0 1.0 1.0 KOG0095 7.0 1.0 0.0 0.729108498258591 0.944559277608525 0.836833887933558 0.2154507793499339 0 0 0 1 K07918 0.0228571428571428 0.0 RAB32; Ras-related protein Rab-32 144.0 6.0 0.0 2.0 0.5 E 12.0 0.0 1.0 1.0 KOG4423 12.0 1.0 0.0 0.698549629213592 0.952555585921495 0.8255526075675435 0.254005956707903 0 0 0 1 K07920 0.0028571428571428 0.0 RAB33B; Ras-related protein Rab-33B path:map04140 Autophagy - animal 183.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0084 1.0 1.0 0.0 0 0 0 0 K07921 0.0028571428571428 0.0 RAB34; Ras-related protein Rab-34 204.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0094 1.0 1.0 0.0 0 0 0 0 K07922 0.0028571428571428 0.0 RAB36; Ras-related protein Rab-36 204.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0094 1.0 1.0 0.0 0 0 0 0 K07923 0.0142857142857142 0.0 RAB38; Ras-related protein Rab-38 165.0 4.0 3.0 2.0 0.8 E 5.0 0.0 1.0 1.0 KOG4423 5.0 1.0 0.0 0.574735820359332 0.935600112118734 0.7551679662390329 0.3608642917594019 0 0 0 1 K07924 0.0114285714285714 0.0 RAB39A; Ras-related protein Rab-39A 160.0 4.0 0.0 1.0 1.0 U 4.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 4.0 1.0 0.0 0.785760843879408 0.955674251997095 0.8707175479382515 0.1699134081176869 0 0 1 1 K07925 0.0142857142857142 0.0028490028490028 RAB39B; Ras-related protein Rab-39B path:map04140,path:map05014,path:map05022 Autophagy - animal,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases 171.0 6.0 0.0 1.0 1.0 U 5.0 1.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 6.0 0.8333333333333334 0.1666666666666666 0.898398797463982 0.98311839757691 0.940758597520446 0.084719600112928 0 0 1 1 K07928 0.0028571428571428 0.0 RAB40; Ras-related protein Rab-40 198.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0078 1.0 1.0 0.0 0 0 0 0 K07930 0.0228571428571428 0.0 RAB43; Ras-related protein Rab-43 163.0 17.0 16.0 3.0 0.894736842105263 U 19.0 0.0 1.0 1.0 KOG0084 19.0 1.0 0.0 0.357754625409761 0.560712893628581 0.459233759519171 0.20295826821882 0 0 0 0 K07931 0.0085714285714285 0.0 RABL2; Rab-like protein 2 170.0 3.0 0.0 1.0 1.0 J 3.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 3.0 1.0 0.0 0 0 0 0 K07936 0.0085714285714285 0.0 RAN; GTP-binding nuclear protein Ran path:map03008,path:map03013,path:map03250,path:map05166 Ribosome biogenesis in eukaryotes,Nucleocytoplasmic transport,Viral life cycle - HIV-1,Human T-cell leukemia virus 1 infection 38.0 1.0 0.0 3.0 0.333333333333333 A 3.0 0.0 3.0 0.333333333333333 KOG0096 3.0 1.0 0.0 0 0 0 0 K07937 0.0342857142857142 0.0 ARF1_2; ADP-ribosylation factor 1/2 path:map04072,path:map04144,path:map05110,path:map05130,path:map05131,path:map05132,path:map05134 Phospholipase D signaling pathway,Endocytosis,Vibrio cholerae infection,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Legionellosis 108.0 15.0 11.0 4.0 0.714285714285714 U 21.0 0.0 2.0 0.952380952380952 COG1100 GTPase_SAR1_family_domain Gem1 21.0 1.0 0.0 0.685232255167195 0.745249217834613 0.7152407365009039 0.0600169626674179 0 0 0 1 K07938 0.0142857142857142 0.0 ARF3; ADP-ribosylation factor 3 path:map04144 Endocytosis 172.0 5.0 4.0 2.0 0.833333333333333 U 6.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 6.0 1.0 0.0 0.732291158098702 1.87225470723693e-05 0.3661549403228872 0.7322724355516297 0 0 0 1 K07939 0.0085714285714285 0.0 ARF4; ADP-ribosylation factor 4 path:map04144 Endocytosis 234.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 3.0 1.0 0.0 0 0 0 0 K07940 0.0028571428571428 0.0 ARF5; ADP-ribosylation factor 5 path:map04144 Endocytosis 292.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07941 0.0085714285714285 0.0 ARF6; ADP-ribosylation factor 6 path:map04014,path:map04072,path:map04144,path:map04666,path:map05130,path:map05131,path:map05132,path:map05135 Ras signaling pathway,Phospholipase D signaling pathway,Endocytosis,Fc gamma R-mediated phagocytosis,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Yersinia infection 156.0 3.0 2.0 2.0 0.75 U 4.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 4.0 1.0 0.0 0.770122409301929 0.954686672336829 0.862404540819379 0.1845642630349 0 0 1 1 K07942 0.0342857142857142 0.0 ARL1; ADP-ribosylation factor-like protein 1 153.0 14.0 13.0 2.0 0.933333333333333 U 15.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 15.0 1.0 0.0 0.60601615381712 0.912170294033547 0.7590932239253335 0.3061541402164269 0 0 0 1 K07943 0.0314285714285714 0.0 ARL2; ADP-ribosylation factor-like protein 2 136.0 14.0 10.0 3.0 0.736842105263158 U 19.0 0.0 1.0 1.0 KOG0073 19.0 1.0 0.0 0.608012857859626 0.87475806876776 0.7413854633136929 0.2667452109081339 0 0 0 1 K07944 0.0228571428571428 0.0 ARL3; ADP-ribosylation factor-like protein 3 101.0 14.0 11.0 3.0 0.777777777777778 U 18.0 0.0 2.0 0.833333333333333 COG1100 GTPase_SAR1_family_domain Gem1 18.0 1.0 0.0 0.586164991237224 0.908361917800015 0.7472634545186194 0.322196926562791 0 0 0 1 K07945 0.0085714285714285 0.0 ARL4; ADP-ribosylation factor-like protein 4 105.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 3.0 1.0 0.0 0 0 0 0 K07950 0.0028571428571428 0.0 ARL5B; ADP-ribosylation factor-like protein 5B 187.0 1.0 0.0 1.0 1.0 BDLTU 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07951 0.0085714285714285 0.0 ARL6, BBS3; ADP-ribosylation factor-like protein 6 147.0 3.0 0.0 1.0 1.0 BDLTU 3.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 3.0 1.0 0.0 0 0 0 0 K07952 0.0142857142857142 0.0 ARFRP1; ADP-ribosylation factor related protein 1 297.0 5.0 0.0 1.0 1.0 U 5.0 0.0 1.0 1.0 KOG0076 5.0 1.0 0.0 0.359674588394256 0.757687533298577 0.5586810608464164 0.398012944904321 0 0 0 0 K07953 0.0057142857142857 0.0 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-] path:map04141,path:map05134 Protein processing in endoplasmic reticulum,Legionellosis 278.0 2.0 0.0 1.0 1.0 U 2.0 0.0 1.0 1.0 KOG0077 2.0 1.0 0.0 0 0 0 0 K07955 0.02 0.0 ARL8; ADP-ribosylation factor-like protein 8 path:map05132 Salmonella infection 117.0 6.0 4.0 3.0 0.666666666666667 U 9.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 9.0 1.0 0.0 0.443499861722458 0.884460416178024 0.663980138950241 0.440960554455566 0 0 0 0 K07958 0.0028571428571428 0.0 ARL10; ADP-ribosylation factor-like protein 10 185.0 1.0 0.0 1.0 1.0 KLT 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K07959 0.0228571428571428 0.0 ARL11; ADP-ribosylation factor-like protein 11 153.0 8.0 0.0 1.0 1.0 U 8.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 8.0 1.0 0.0 0.0193132945157129 0.195103684552594 0.1072084895341534 0.1757903900368811 0 0 0 0 K07962 0.0057142857142857 0.0 ARL13B, ARL2L1; ADP-ribosylation factor-like protein 13B 138.0 2.0 0.0 1.0 1.0 BDLTU 2.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 2.0 1.0 0.0 0 0 0 0 K07963 0.0057142857142857 0.0 TRIM23, ARFD1; tripartite motif-containing protein 23 [EC:2.3.2.27] 161.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 3.0 1.0 0.0 0 0 0 0 K07976 0.0485714285714285 0.0028490028490028 RAB; Rab family, other 90.0 26.0 18.0 6.0 0.590909090909091 U 43.0 1.0 9.0 0.295454545454545 COG1100 GTPase_SAR1_family_domain Gem1 44.0 0.9772727272727272 0.0227272727272727 0.602534069998976 0.898540168237774 0.750537119118375 0.2960060982387981 0 0 0 1 K07977 0.0314285714285714 0.0 86.0 12.0 7.0 4.0 0.6 U 20.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 20.0 1.0 0.0 0.728398934529605 0.928469058171413 0.828433996350509 0.2000701236418079 0 0 0 1 K07978 0.0 0.0626780626780626 plmA; GntR family transcriptional regulator 238.0 23.0 0.0 1.0 1.0 K 0.0 23.0 2.0 0.782608695652174 COG1725 DNA-binding_transcriptional_regulator_YhcF,_GntR_family YhcF 23.0 0.0 1.0 0.0122922153700965 0.0693218139667377 0.0408070146684171 0.0570295985966411 0 0 0 0 K07979 0.0314285714285714 0.2421652421652421 ytrA; GntR family transcriptional regulator 62.0 151.0 0.0 1.0 1.0 K 12.0 139.0 1.0 1.0 COG1725 DNA-binding_transcriptional_regulator_YhcF,_GntR_family YhcF 151.0 0.0794701986754966 0.9205298013245032 0.251874867645861 0.110797625082079 0.18133624636397 0.1410772425637819 0 0 0 0 K07991 0.56 0.0 flaK; archaeal preflagellin peptidase FlaK [EC:3.4.23.52] 71.0 173.0 136.0 3.0 0.819905213270142 N 216.0 0.0 3.0 0.972222222222222 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 216.0 1.0 0.0 0.906219444142166 0.530111816919242 0.718165630530704 0.376107627222924 0 0 1 1 K07994 0.0028571428571428 0.0 MMP13; matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-] path:map04657,path:map04926,path:map04928 IL-17 signaling pathway,Relaxin signaling pathway,Parathyroid hormone synthesis, secretion and action 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K07999 0.0028571428571428 0.0 MMP20; matrix metalloproteinase-20 (enamelysin) [EC:3.4.24.-] 87.0 1.0 0.0 1.0 1.0 OW 1.0 0.0 1.0 1.0 KOG1565 1.0 1.0 0.0 0 0 0 0 K08017 0.0171428571428571 0.0 AVIL; advillin 188.0 6.0 0.0 1.0 1.0 Z 6.0 0.0 1.0 1.0 KOG0443 6.0 1.0 0.0 0.0413082560174425 0.999999088580605 0.5206536722990238 0.9586908325631626 0 0 0 0 K08021 0.0 0.0028490028490028 ALOX12B; arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-] path:map00590,path:map01100,path:map04726 Arachidonic acid metabolism,Metabolic pathways,Serotonergic synapse 75.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 28IFU 1.0 0.0 1.0 0 0 0 0 K08022 0.0 0.0028490028490028 ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-] path:map00590,path:map01100,path:map04726 Arachidonic acid metabolism,Metabolic pathways,Serotonergic synapse 75.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 28IFU 1.0 0.0 1.0 0 0 0 0 K08068 0.0171428571428571 0.074074074074074 siaA, neuC1; UDP-N-acetylglucosamine 2-epimerase (hydrolysing) [EC:3.2.1.183] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 286.0 32.0 29.0 2.0 0.914285714285714 M 8.0 27.0 2.0 0.914285714285714 COG0381 UDP-N-acetylglucosamine_2-epimerase WecB 35.0 0.2285714285714285 0.7714285714285715 0.262764473636854 0.739879223075968 0.501321848356411 0.4771147494391139 0 0 0 0 K08070 0.0314285714285714 0.0911680911680911 E1.3.1.74; 2-alkenal reductase [EC:1.3.1.74] 255.0 40.0 32.0 3.0 0.816326530612245 O 11.0 38.0 1.0 1.0 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 49.0 0.2244897959183673 0.7755102040816326 0.0226384947204939 0.922542316649401 0.4725904056849475 0.899903821928907 0 0 0 0 K08073 0.0028571428571428 0.0 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 264.0 1.0 0.0 1.0 1.0 KLO 1.0 0.0 1.0 1.0 COG0241 Histidinol_phosphatase/D-glycero-mannoheptose_bisphosphatephosphatase,_HAD_superfamily HisB1/GmhB 1.0 1.0 0.0 0 0 0 0 K08076 0.0 0.0113960113960113 E3.4.24.21; astacin [EC:3.4.24.21] 292.0 4.0 0.0 1.0 1.0 NU 0.0 4.0 2.0 0.75 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 4.0 0.0 1.0 0.166673294864644 0.25368173782885 0.210177516346747 0.087008442964206 0 0 0 0 K08077 0.06 0.0341880341880341 NUDT14; UDP-sugar diphosphatase [EC:3.6.1.45] 129.0 30.0 22.0 2.0 0.789473684210526 F 23.0 15.0 2.0 0.789473684210526 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 38.0 0.6052631578947368 0.3947368421052631 0.0145137877154124 0.0207742110301571 0.0176439993727847 0.0062604233147447 0 0 0 0 K08080 0.0 0.0056980056980056 CMAH; CMP-N-acetylneuraminate monooxygenase [EC:1.14.18.2] path:map00520,path:map01250 Amino sugar and nucleotide sugar metabolism,Biosynthesis of nucleotide sugars 419.0 2.0 0.0 1.0 1.0 P 0.0 2.0 2.0 0.5 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 2.0 0.0 1.0 0 0 0 0 K08081 0.0 0.017094017094017 TR1; tropinone reductase I [EC:1.1.1.206] path:map00960,path:map01100,path:map01110 Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 253.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0230239450881708 0.0955177795915014 0.0592708623398361 0.0724938345033306 0 0 0 0 K08082 0.0 0.0569800569800569 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3] path:map02020 Two-component system 247.0 21.0 0.0 1.0 1.0 T 0.0 21.0 1.0 1.0 COG2972 Sensor_histidine_kinase_YesM YesM 21.0 0.0 1.0 0.0028906260494839 0.0067590467114374 0.0048248363804606 0.0038684206619535 0 0 0 0 K08083 0.0 0.0512820512820512 algR; two-component system, LytTR family, response regulator AlgR path:map02020 Two-component system 204.0 9.0 2.0 3.0 0.5 KT 0.0 18.0 1.0 1.0 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 18.0 0.0 1.0 0.0059809928983073 0.0080947585172136 0.0070378757077604 0.0021137656189063 0 0 0 0 K08084 0.0 0.1709401709401709 fimT; type IV fimbrial biogenesis protein FimT 32.0 92.0 88.0 3.0 0.948453608247423 NU 0.0 97.0 3.0 0.927835051546392 COG4970 Type_IV_pilus_assembly_protein_FimT FimT 97.0 0.0 1.0 0.878422266662222 0.0309427680442176 0.4546825173532198 0.8474794986180044 0 0 1 1 K08085 0.0 0.0085470085470085 fimU; type IV fimbrial biogenesis protein FimU 116.0 3.0 0.0 1.0 1.0 NU 0.0 3.0 1.0 1.0 COG4970 Type_IV_pilus_assembly_protein_FimT FimT 3.0 0.0 1.0 0 0 0 0 K08086 0.0 0.1025641025641025 fimV; pilus assembly protein FimV 46.0 29.0 26.0 5.0 0.805555555555556 NU 0.0 43.0 9.0 0.636363636363636 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 43.0 0.0 1.0 0.0104627170095917 0.0158044422282335 0.0131335796189126 0.0053417252186417 0 0 0 0 K08087 0.0 0.0085470085470085 fimW; fimbrial protein FimW 184.0 3.0 0.0 1.0 1.0 K 0.0 3.0 2.0 0.666666666666667 COG2202 PAS_domain PAS 3.0 0.0 1.0 0 0 0 0 K08092 0.0 0.037037037037037 dlgD; 3-dehydro-L-gulonate 2-dehydrogenase [EC:1.1.1.130] path:map00040,path:map00053,path:map01100 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways 326.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 13.0 0.0 1.0 0.0720467543298206 0.127446367241274 0.0997465607855473 0.0553996129114534 0 0 0 0 K08093 0.1542857142857142 0.0569800569800569 hxlA; 3-hexulose-6-phosphate synthase [EC:4.1.2.43] path:map00030,path:map00680,path:map01100,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 133.0 61.0 44.0 2.0 0.782051282051282 G 54.0 24.0 2.0 0.794871794871795 COG0269 3-keto-L-gulonate-6-phosphate_decarboxylase UlaD 78.0 0.6923076923076923 0.3076923076923077 0.374911072692425 0.25913945827464 0.3170252654835325 0.115771614417785 0 0 0 0 K08094 0.3657142857142857 0.0655270655270655 hxlB; 6-phospho-3-hexuloisomerase [EC:5.3.1.27] path:map00030,path:map00680,path:map01100,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 131.0 165.0 154.0 2.0 0.9375 M 146.0 30.0 1.0 1.0 COG0794 D-arabinose_5-phosphate_isomerase_GutQ GutQ 176.0 0.8295454545454546 0.1704545454545454 0.498149766681047 0.770647980772425 0.634398873726736 0.272498214091378 0 0 0 0 K08095 0.0 0.0028490028490028 E3.1.1.74; cutinase [EC:3.1.1.74] 183.0 13.0 0.0 1.0 1.0 M 0.0 13.0 2.0 0.846153846153846 2A1QU 13.0 0.0 1.0 4.97618876374526e-13 4.29774138798171e-12 2.397680132178118e-12 3.800122511607185e-12 0 0 0 0 K08096 0.2628571428571428 0.0 gch3; GTP cyclohydrolase IIa [EC:3.5.4.29] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 172.0 92.0 86.0 2.0 0.938775510204082 F 98.0 0.0 1.0 1.0 COG2429 Archaeal_GTP_cyclohydrolase_III Gch31 98.0 1.0 0.0 0.176901899034595 0.0119613050290784 0.0944316020318367 0.1649405940055165 0 0 0 0 K08097 0.0685714285714285 0.0598290598290598 comA; phosphosulfolactate synthase [EC:4.4.1.19] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 206.0 26.0 8.0 3.0 0.509803921568627 S 28.0 23.0 2.0 0.862745098039216 COG1809 Phosphosulfolactate_synthase,_CoM_biosynthesis_protein_A ComA 51.0 0.5490196078431373 0.4509803921568627 0.0290765754991782 0.264017225975122 0.1465469007371501 0.2349406504759438 0 0 0 0 K08100 0.0 0.0341880341880341 E1.3.3.5; bilirubin oxidase [EC:1.3.3.5] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 103.0 16.0 15.0 2.0 0.941176470588235 Q 0.0 17.0 1.0 1.0 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 17.0 0.0 1.0 5.775117384036119e-13 0.0016532949522466 0.000826647476412 0.001653294951669 0 0 0 0 K08137 0.0 0.0142450142450142 galP; MFS transporter, SP family, galactose:H+ symporter 436.0 5.0 3.0 3.0 0.625 EGP 0.0 8.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 8.0 0.0 1.0 0 0 0 0 K08138 0.0 0.0484330484330484 xylE; MFS transporter, SP family, xylose:H+ symportor 414.0 19.0 15.0 2.0 0.826086956521739 EGP 0.0 23.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 23.0 0.0 1.0 0 0 0 0 K08139 0.0028571428571428 0.0626780626780626 HXT; MFS transporter, SP family, sugar:H+ symporter path:map04113 Meiosis - yeast 415.0 21.0 18.0 3.0 0.807692307692308 EGP 1.0 25.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 26.0 0.0384615384615384 0.9615384615384616 0 0 0 0 K08151 0.0771428571428571 0.1623931623931624 tetA; MFS transporter, DHA1 family, tetracycline resistance protein 279.0 96.0 95.0 2.0 0.989690721649485 EGP 27.0 70.0 2.0 0.989690721649485 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 97.0 0.2783505154639175 0.7216494845360825 0 0 0 0 K08152 0.0 0.0256410256410256 lmrP; MFS transporter, DHA1 family, multidrug resistance protein B 346.0 8.0 5.0 3.0 0.666666666666667 EGP 0.0 12.0 4.0 0.666666666666667 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 12.0 0.0 1.0 0 0 0 0 K08153 0.16 0.0854700854700854 blt; MFS transporter, DHA1 family, multidrug resistance protein 109.0 89.0 75.0 2.0 0.864077669902913 EGP 69.0 34.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 103.0 0.6699029126213593 0.3300970873786408 0 0 0 0 K08154 0.0 0.017094017094017 emrD; MFS transporter, DHA1 family, 2-module integral membrane pump EmrD 387.0 6.0 0.0 1.0 1.0 EGP 0.0 6.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 6.0 0.0 1.0 0 0 0 0 K08156 0.0 0.0398860398860398 araJ; MFS transporter, DHA1 family, arabinose polymer utilization protein 378.0 15.0 0.0 1.0 1.0 EGP 0.0 15.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 15.0 0.0 1.0 0 0 0 0 K08158 0.0028571428571428 0.0 MDR1, FLR1, CAF5; MFS transporter, DHA1 family, multidrug resistance protein 239.0 1.0 0.0 1.0 1.0 Q 1.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 1.0 0.0 0 0 0 0 K08159 0.0 0.0199430199430199 sotB; MFS transporter, DHA1 family, L-arabinose/isopropyl-beta-D-thiogalactopyranoside export protein 386.0 7.0 6.0 2.0 0.875 EGP 0.0 8.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 8.0 0.0 1.0 0 0 0 0 K08160 0.0 0.017094017094017 mdfA, cmr; MFS transporter, DHA1 family, multidrug/chloramphenicol efflux transport protein 406.0 6.0 5.0 2.0 0.857142857142857 EGP 0.0 7.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 7.0 0.0 1.0 0 0 0 0 K08161 0.0657142857142857 0.0655270655270655 mdtG; MFS transporter, DHA1 family, multidrug resistance protein 266.0 47.0 43.0 4.0 0.839285714285714 EGP 26.0 30.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 56.0 0.4642857142857143 0.5357142857142857 0 0 0 0 K08162 0.0028571428571428 0.0341880341880341 mdtH; MFS transporter, DHA1 family, multidrug resistance protein 349.0 7.0 4.0 4.0 0.538461538461538 EGP 1.0 12.0 2.0 0.692307692307692 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 13.0 0.0769230769230769 0.9230769230769232 0 0 0 0 K08163 0.0 0.0085470085470085 mdtL; MFS transporter, DHA1 family, multidrug resistance protein 377.0 4.0 0.0 1.0 1.0 EGP 0.0 4.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 4.0 0.0 1.0 0 0 0 0 K08164 0.0 0.0085470085470085 ybcL; MFS transporter, DHA1 family, putative efflux transporter 386.0 2.0 1.0 2.0 0.666666666666667 EGP 0.0 3.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 3.0 0.0 1.0 0 0 0 0 K08166 0.0228571428571428 0.0256410256410256 mmr; MFS transporter, DHA2 family, methylenomycin A resistance protein 166.0 11.0 3.0 3.0 0.55 G 8.0 12.0 3.0 0.5 COG2271 Sugar_phosphate_permease UhpC 20.0 0.4 0.6 0.0310236520861443 0.046331373372801 0.0386775127294726 0.0153077212866567 0 0 0 0 K08167 0.0028571428571428 0.0997150997150997 smvA, qacA, lfrA; MFS transporter, DHA2 family, multidrug resistance protein 442.0 66.0 62.0 3.0 0.929577464788732 EGP 1.0 70.0 3.0 0.929577464788732 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 71.0 0.0140845070422535 0.9859154929577464 0 0 0 0 K08168 0.0 0.0256410256410256 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter 421.0 11.0 0.0 1.0 1.0 EGP 0.0 11.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 11.0 0.0 1.0 0 0 0 0 K08169 0.0 0.0541310541310541 yebQ; MFS transporter, DHA2 family, multidrug resistance protein 402.0 19.0 17.0 2.0 0.904761904761905 EGP 0.0 21.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 21.0 0.0 1.0 0 0 0 0 K08170 0.0228571428571428 0.0569800569800569 norB, norC; MFS transporter, DHA2 family, multidrug resistance protein 153.0 17.0 3.0 4.0 0.5 G 9.0 24.0 2.0 0.5 COG2271 Sugar_phosphate_permease UhpC 33.0 0.2727272727272727 0.7272727272727273 0.0265636160448502 0.0689587848808137 0.0477612004628319 0.0423951688359634 0 0 0 0 K08172 0.0 0.017094017094017 shiA; MFS transporter, MHS family, shikimate and dehydroshikimate transport protein 417.0 6.0 5.0 2.0 0.857142857142857 EGP 0.0 7.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 7.0 0.0 1.0 0 0 0 0 K08173 0.0 0.0284900284900284 ydfJ; MFS transporter, MHS family, metabolite:H+ symporter 422.0 12.0 11.0 2.0 0.923076923076923 EGP 0.0 13.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 13.0 0.0 1.0 0 0 0 0 K08174 0.0 0.0199430199430199 glcP; MFS transporter, FHS family, glucose/mannose:H+ symporter 333.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG0738 Fucose_permease FucP 9.0 0.0 1.0 0.0612167353586014 0.320267452797686 0.1907420940781437 0.2590507174390846 0 0 0 0 K08176 0.0942857142857142 0.0056980056980056 PHO84; MFS transporter, PHS family, inorganic phosphate transporter 335.0 62.0 58.0 2.0 0.939393939393939 G 64.0 2.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 66.0 0.9696969696969696 0.0303030303030303 0.0088930091698049 0.0272358807830766 0.0180644449764407 0.0183428716132717 0 0 0 0 K08177 0.1771428571428571 0.1851851851851851 oxlT; MFS transporter, OFA family, oxalate/formate antiporter 268.0 63.0 5.0 3.0 0.440559440559441 P 68.0 75.0 4.0 0.482517482517483 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 143.0 0.4755244755244755 0.5244755244755245 0.883773539188527 0.871104683770414 0.8774391114794704 0.012668855418113 1 1 1 1 K08178 0.0285714285714285 0.0512820512820512 JEN; MFS transporter, SHS family, lactate transporter 316.0 30.0 23.0 4.0 0.769230769230769 EGP 18.0 21.0 2.0 0.974358974358975 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 39.0 0.4615384615384615 0.5384615384615384 0 0 0 0 K08187 0.0257142857142857 0.0 SLC16A10; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10 path:map04919,path:map04974 Thyroid hormone signaling pathway,Protein digestion and absorption 153.0 8.0 7.0 2.0 0.888888888888889 C 9.0 0.0 1.0 1.0 COG1413 HEAT_repeat HEAT 9.0 1.0 0.0 9.023554527711368e-13 1.24917038371562e-08 6.246303096304486e-09 1.2490801481703429e-08 0 0 0 0 K08191 0.0 0.0883190883190883 exuT; MFS transporter, ACS family, hexuronate transporter 319.0 35.0 31.0 2.0 0.897435897435897 G 0.0 39.0 2.0 0.923076923076923 COG2271 Sugar_phosphate_permease UhpC 39.0 0.0 1.0 0.0082247126545258 0.0245579881268361 0.0163913503906809 0.0163332754723103 0 0 0 0 K08194 0.0142857142857142 0.0455840455840455 dgoT; MFS transporter, ACS family, D-galactonate transporter 353.0 23.0 21.0 2.0 0.92 G 6.0 19.0 2.0 0.8 COG2271 Sugar_phosphate_permease UhpC 25.0 0.24 0.76 0.0180349572337712 0.049950736079906 0.0339928466568386 0.0319157788461348 0 0 0 0 K08195 0.0028571428571428 0.0541310541310541 pcaK; MFS transporter, AAHS family, 4-hydroxybenzoate transporter 347.0 20.0 6.0 2.0 0.588235294117647 EGP 1.0 33.0 2.0 0.588235294117647 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 34.0 0.0294117647058823 0.9705882352941176 0 0 0 0 K08196 0.0057142857142857 0.017094017094017 mucK; MFS transporter, AAHS family, cis,cis-muconate transporter 383.0 7.0 6.0 2.0 0.875 EGP 2.0 6.0 2.0 0.875 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 8.0 0.25 0.75 0 0 0 0 K08217 0.0342857142857142 0.1082621082621082 mef; MFS transporter, DHA3 family, macrolide efflux protein 305.0 60.0 59.0 3.0 0.967741935483871 EGP 19.0 43.0 2.0 0.967741935483871 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 62.0 0.3064516129032258 0.6935483870967742 0 0 0 0 K08218 0.0085714285714285 0.2735042735042735 ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG path:map01501 beta-Lactam resistance 265.0 62.0 25.0 4.0 0.539130434782609 EGP 4.0 111.0 7.0 0.539130434782609 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 115.0 0.0347826086956521 0.9652173913043478 0 0 0 0 K08219 0.0 0.0113960113960113 UMF2; MFS transporter, UMF2 family, putative MFS family transporter protein 369.0 3.0 2.0 2.0 0.75 EGP 0.0 4.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 4.0 0.0 1.0 0 0 0 0 K08220 0.0 0.0028490028490028 FLVCR, SLC49A1_2; MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein 391.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 1.0 0.0 1.0 0 0 0 0 K08221 0.0714285714285714 0.0683760683760683 yitG, ymfD, yfmO; MFS transporter, ACDE family, multidrug resistance protein 292.0 35.0 18.0 2.0 0.673076923076923 EGP 25.0 27.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 52.0 0.4807692307692308 0.5192307692307693 0 0 0 0 K08222 0.0142857142857142 0.0512820512820512 yqgE; MFS transporter, YQGE family, putative transporter 280.0 17.0 13.0 2.0 0.80952380952381 EGP 5.0 19.0 3.0 0.708333333333333 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 24.0 0.2083333333333333 0.7916666666666666 0 0 0 0 K08223 0.0714285714285714 0.2393162393162393 fsr; MFS transporter, FSR family, fosmidomycin resistance protein 232.0 54.0 11.0 3.0 0.391304347826087 EGP 38.0 100.0 5.0 0.492753623188406 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 138.0 0.2753623188405797 0.7246376811594203 0 0 0 0 K08224 0.0 0.1766381766381766 ynfM; MFS transporter, YNFM family, putative membrane transport protein 326.0 70.0 69.0 2.0 0.985915492957746 EGP 0.0 71.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 71.0 0.0 1.0 0 0 0 0 K08225 0.0028571428571428 0.0826210826210826 entS; MFS transporter, ENTS family, enterobactin (siderophore) exporter 361.0 31.0 30.0 2.0 0.96875 EGP 1.0 31.0 2.0 0.96875 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 32.0 0.03125 0.96875 0 0 0 0 K08226 0.0114285714285714 0.0883190883190883 pucC; MFS transporter, BCD family, chlorophyll transporter 362.0 31.0 15.0 3.0 0.645833333333333 G 4.0 44.0 3.0 0.583333333333333 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 48.0 0.0833333333333333 0.9166666666666666 0.036567747648044 0.296852588637035 0.1667101681425395 0.260284840988991 0 0 0 0 K08227 0.0 0.0142450142450142 lplT; MFS transporter, LPLT family, lysophospholipid transporter 377.0 4.0 3.0 2.0 0.8 EGP 0.0 5.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 5.0 0.0 1.0 0 0 0 0 K08234 0.0228571428571428 0.2507122507122507 yaeR; glyoxylase I family protein 33.0 112.0 109.0 3.0 0.957264957264957 E 9.0 108.0 2.0 0.982905982905983 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 117.0 0.0769230769230769 0.9230769230769232 0.0296615954794645 0.311339346909894 0.1705004711946792 0.2816777514304295 0 0 0 0 K08252 0.0 0.1225071225071225 E2.7.10.1; receptor protein-tyrosine kinase [EC:2.7.10.1] 121.0 39.0 31.0 3.0 0.75 D 0.0 52.0 1.0 1.0 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 52.0 0.0 1.0 0.0268767610725938 0.103348962729771 0.0651128619011824 0.0764722016571771 0 0 0 0 K08253 0.0 0.0569800569800569 E2.7.10.2; non-specific protein-tyrosine kinase [EC:2.7.10.2] 218.0 15.0 11.0 4.0 0.576923076923077 DM 0.0 26.0 2.0 0.884615384615385 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 26.0 0.0 1.0 0.0188967813962125 0.643147240106011 0.3310220107511117 0.6242504587097985 0 0 0 0 K08255 0.0 0.0056980056980056 cdr; CoA-disulfide reductase [EC:1.8.1.14] 434.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 2.0 0.0 1.0 0 0 0 0 K08256 0.0371428571428571 0.150997150997151 pimA; phosphatidyl-myo-inositol alpha-mannosyltransferase [EC:2.4.1.345] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 177.0 72.0 64.0 2.0 0.9 M 13.0 66.0 3.0 0.95 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 79.0 0.1645569620253164 0.8354430379746836 0.255143859030005 0.974377975629781 0.614760917329893 0.719234116599776 0 0 0 0 K08258 0.0 0.0028490028490028 sspB2, sspP, scpA; staphopain A [EC:3.4.22.48] 367.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DXBB 1.0 0.0 1.0 0 0 0 0 K08259 0.0 0.0797720797720797 lytM; lysostaphin [EC:3.4.24.75] 113.0 47.0 46.0 3.0 0.959183673469388 M 0.0 49.0 2.0 0.979591836734694 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 49.0 0.0 1.0 0.915853304748276 0.060793424600484 0.48832336467438 0.855059880147792 0 0 1 1 K08260 0.2314285714285714 0.0 cbiZ; adenosylcobinamide hydrolase [EC:3.5.1.90] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 142.0 71.0 58.0 2.0 0.845238095238095 H 84.0 0.0 3.0 0.964285714285714 COG1865 Adenosylcobinamide_amidohydrolase CbiZ 84.0 1.0 0.0 0.0354936607460418 0.0162676926598157 0.0258806767029287 0.0192259680862261 0 0 0 0 K08261 0.0 0.0313390313390313 E1.1.99.21; D-sorbitol dehydrogenase (acceptor) [EC:1.1.99.21] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 204.0 7.0 4.0 4.0 0.583333333333333 IQ 0.0 12.0 4.0 0.583333333333333 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 12.0 0.0 1.0 0.0058720175074896 0.0233202073432902 0.0145961124253899 0.0174481898358006 0 0 0 0 K08264 0.22 0.0085470085470085 hdrD; heterodisulfide reductase subunit D [EC:1.8.98.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 200.0 192.0 0.0 1.0 1.0 C 189.0 3.0 1.0 1.0 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 192.0 0.984375 0.015625 0.953150184810003 0.987445934225409 0.970298059517706 0.034295749415406 0 0 1 1 K08265 0.0657142857142857 0.0028490028490028 hdrE; heterodisulfide reductase subunit E [EC:1.8.98.1] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 206.0 27.0 0.0 1.0 1.0 C 26.0 1.0 1.0 1.0 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 27.0 0.9629629629629628 0.037037037037037 0.0207854904055243 0.0107256103821208 0.0157555503938225 0.0100598800234034 0 0 0 0 K08266 0.0 0.0028490028490028 MLST8, GBL; target of rapamycin complex subunit LST8 path:map04136,path:map04138,path:map04140,path:map04150,path:map04151,path:map04714 Autophagy - other,Autophagy - yeast,Autophagy - animal,mTOR signaling pathway,PI3K-Akt signaling pathway,Thermogenesis 390.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG0315 1.0 0.0 1.0 0 0 0 0 K08276 0.0 0.0199430199430199 eco; ecotin 124.0 4.0 0.0 2.0 0.5 M 0.0 8.0 1.0 1.0 COG4574 Serine_protease_inhibitor_ecotin Eco 8.0 0.0 1.0 0.026813062270208 0.0464023269310685 0.0366076946006382 0.0195892646608605 0 0 0 0 K08277 0.0 0.0028490028490028 caiF; transcriptional activator CaiF 131.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 2BXKV 1.0 0.0 1.0 0 0 0 0 K08279 0.0257142857142857 0.037037037037037 caiE; carnitine operon protein CaiE 167.0 23.0 0.0 1.0 1.0 S 9.0 14.0 1.0 1.0 COG0663 Carbonic_anhydrase_or_acetyltransferase,_isoleucine_patch_superfamily PaaY 23.0 0.391304347826087 0.6086956521739131 0.564849041135347 0.740352667389529 0.652600854262438 0.175503626254182 0 1 0 1 K08280 0.0028571428571428 0.0085470085470085 wbbJ; lipopolysaccharide O-acetyltransferase [EC:2.3.1.-] 101.0 3.0 2.0 2.0 0.75 S 1.0 3.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 4.0 0.25 0.75 0.0754209915958218 0.162340379573716 0.1188806855847689 0.0869193879778942 0 0 0 0 K08281 0.16 0.3504273504273504 pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] path:map00760,path:map01100,path:map01240 Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of cofactors 79.0 188.0 184.0 2.0 0.979166666666667 Q 58.0 134.0 2.0 0.979166666666667 COG1335 Nicotinamidase-related_amidase PncA 192.0 0.3020833333333333 0.6979166666666666 0.213715728696991 0.0727854095599898 0.1432505691284903 0.1409303191370012 0 0 0 0 K08282 0.1314285714285714 0.2507122507122507 E2.7.11.1; non-specific serine/threonine protein kinase [EC:2.7.11.1] 12.0 61.0 21.0 7.0 0.35672514619883 T 46.0 116.0 11.0 0.350877192982456 COG0553 Superfamily_II_DNA_or_RNA_helicase,_SNF2_family HepA 162.0 0.2839506172839506 0.7160493827160493 0.0068669085267817 0.0316083433223945 0.0192376259245881 0.0247414347956127 0 0 0 0 K08286 0.0028571428571428 0.0 E2.7.11.-; protein-serine/threonine kinase [EC:2.7.11.-] 329.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 1.0 1.0 0.0 0 0 0 0 K08289 0.1228571428571428 0.1481481481481481 purT; phosphoribosylglycinamide formyltransferase 2 [EC:6.3.1.21] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 342.0 95.0 0.0 1.0 1.0 F 43.0 52.0 1.0 1.0 COG0027 Formate-dependent_phosphoribosylglycinamide_formyltransferase_(GAR_transformylase) PurT 95.0 0.4526315789473684 0.5473684210526316 0.142451482259212 0.451553837208135 0.2970026597336735 0.309102354948923 0 0 0 0 K08295 0.04 0.0712250712250712 abmG; 2-aminobenzoate-CoA ligase [EC:6.2.1.32] path:map00627,path:map01110,path:map01120 Aminobenzoate degradation,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 477.0 43.0 0.0 1.0 1.0 I 14.0 29.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 43.0 0.3255813953488372 0.6744186046511628 0.0950200298719646 0.0224291390491945 0.0587245844605795 0.0725908908227701 0 0 0 0 K08296 0.1285714285714285 0.4757834757834758 sixA; phosphohistidine phosphatase [EC:3.1.3.-] 38.0 228.0 218.0 3.0 0.942148760330578 T 47.0 195.0 3.0 0.946280991735537 COG2062 Phosphohistidine_phosphatase_SixA SixA 242.0 0.1942148760330578 0.8057851239669421 0.0074945598453785 0.0077916179889646 0.0076430889171715 0.000297058143586 0 0 0 0 K08297 0.0028571428571428 0.0199430199430199 caiA; crotonobetainyl-CoA dehydrogenase [EC:1.3.8.13] 359.0 8.0 4.0 2.0 0.666666666666667 I 1.0 11.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 12.0 0.0833333333333333 0.9166666666666666 0.005660682663182 0.0250472816640599 0.0153539821636209 0.0193865990008779 0 0 0 0 K08298 0.0028571428571428 0.0142450142450142 caiB; L-carnitine CoA-transferase [EC:2.8.3.21] 369.0 12.0 0.0 1.0 1.0 C 1.0 11.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 12.0 0.0833333333333333 0.9166666666666666 4.95237184226397e-12 0.0203817430956154 0.0101908715502838 0.020381743090663 0 0 0 0 K08299 0.0085714285714285 0.0911680911680911 caiD; crotonobetainyl-CoA hydratase [EC:4.2.1.149] 204.0 50.0 0.0 1.0 1.0 I 3.0 47.0 2.0 0.94 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 50.0 0.06 0.94 0.0054060607529071 0.229437057059798 0.1174215589063525 0.2240309963068909 0 0 0 0 K08300 0.0085714285714285 0.4472934472934473 rne; ribonuclease E [EC:3.1.26.12] path:map03018 RNA degradation 267.0 168.0 160.0 7.0 0.888888888888889 J 3.0 186.0 11.0 0.888888888888889 COG1530 Ribonuclease_G_or_E CafA 189.0 0.0158730158730158 0.984126984126984 0.0220730771822558 0.154286603921332 0.0881798405517939 0.1322135267390762 0 0 0 0 K08301 0.0114285714285714 0.5982905982905983 rng, cafA; ribonuclease G [EC:3.1.26.-] 217.0 224.0 213.0 6.0 0.910569105691057 J 4.0 242.0 8.0 0.910569105691057 COG1530 Ribonuclease_G_or_E CafA 246.0 0.016260162601626 0.983739837398374 0.0425362713167622 0.143182583524279 0.0928594274205206 0.1006463122075168 0 0 0 0 K08302 0.0657142857142857 0.1054131054131054 gatY-kbaY; tagatose 1,6-diphosphate aldolase GatY/KbaY [EC:4.1.2.40] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 196.0 59.0 56.0 3.0 0.921875 G 24.0 40.0 1.0 1.0 COG0191 Fructose/tagatose_bisphosphate_aldolase Fba 64.0 0.375 0.625 0.431890406951723 0.938248061298864 0.6850692341252935 0.506357654347141 0 0 0 0 K08303 0.3228571428571428 0.4757834757834758 prtC, trhP; U32 family peptidase [EC:3.4.-.-] path:map05120 Epithelial cell signaling in Helicobacter pylori infection 137.0 429.0 0.0 1.0 1.0 O 156.0 274.0 3.0 0.988425925925926 COG0826 23S_rRNA_C2501_and_tRNA_U34_5'-hydroxylation_protein_RlhA/YrrN/YrrO,_U32_peptidase_family RlhA 430.0 0.3627906976744186 0.6372093023255814 0.157841123733574 0.430527207074983 0.2941841654042785 0.272686083341409 0 0 0 0 K08304 0.0 0.2079772079772079 mltA; membrane-bound lytic murein transglycosylase A [EC:4.2.2.-] 223.0 83.0 0.0 1.0 1.0 M 0.0 83.0 1.0 1.0 COG2821 Membrane-bound_lytic_murein_transglycosylase MltA 83.0 0.0 1.0 0.0035007567181421 0.0067482785524542 0.0051245176352981 0.0032475218343121 0 0 0 0 K08305 0.0 0.2279202279202279 mltB; membrane-bound lytic murein transglycosylase B [EC:4.2.2.-] 178.0 110.0 109.0 2.0 0.990990990990991 M 0.0 111.0 3.0 0.981981981981982 COG2951 Membrane-bound_lytic_murein_transglycosylase_B MltB 111.0 0.0 1.0 0.0044534401070505 0.0144689198864956 0.009461179996773 0.0100154797794451 0 0 0 0 K08306 0.0 0.0398860398860398 mltC; membrane-bound lytic murein transglycosylase C [EC:4.2.2.-] 317.0 16.0 0.0 1.0 1.0 M 0.0 16.0 1.0 1.0 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 16.0 0.0 1.0 0.0127966282497219 0.0195639099844674 0.0161802691170946 0.0067672817347455 0 0 0 0 K08307 0.0028571428571428 0.3532763532763532 mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-] 109.0 154.0 153.0 3.0 0.987179487179487 M 1.0 154.0 6.0 0.935897435897436 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 155.0 0.0064516129032258 0.9935483870967742 0.0241044138421335 0.008543823733667 0.0163241187879002 0.0155605901084665 0 0 0 0 K08308 0.0 0.0227920227920227 mltE, emtA; membrane-bound lytic murein transglycosylase E [EC:4.2.2.-] 147.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 8.0 0.0 1.0 0.0115667789601423 0.0295236774738442 0.0205452282169932 0.0179568985137019 0 0 0 0 K08309 0.0257142857142857 0.5612535612535613 slt; soluble lytic murein transglycosylase [EC:4.2.2.-] 25.0 252.0 219.0 11.0 0.754491017964072 M 9.0 319.0 15.0 0.676646706586826 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 328.0 0.0274390243902439 0.972560975609756 0.257797356670488 0.125053584684975 0.1914254706777314 0.132743771985513 0 0 0 0 K08310 0.0171428571428571 0.0968660968660968 nudB, ntpA; dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 47.0 29.0 16.0 2.0 0.69047619047619 L 7.0 35.0 2.0 0.666666666666667 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 42.0 0.1666666666666666 0.8333333333333334 0.023125033176903 0.0537917318639175 0.0384583825204102 0.0306666986870145 0 0 0 0 K08311 0.0228571428571428 0.1908831908831909 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-] path:map03018 RNA degradation 104.0 47.0 16.0 2.0 0.602564102564102 L 8.0 70.0 2.0 0.602564102564103 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 78.0 0.1025641025641025 0.8974358974358975 0.0073622830131941 0.151537611822903 0.0794499474180485 0.1441753288097089 0 0 0 0 K08312 0.0085714285714285 0.0569800569800569 nudE; ADP-ribose diphosphatase [EC:3.6.1.-] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 152.0 23.0 0.0 1.0 1.0 L 3.0 20.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 23.0 0.1304347826086956 0.8695652173913043 0.0154267646240278 0.862467174655849 0.4389469696399384 0.8470404100318212 0 0 0 0 K08313 0.0 0.0142450142450142 fsaA, mipB; fructose-6-phosphate aldolase 1 [EC:4.1.2.-] 216.0 4.0 2.0 2.0 0.666666666666667 G 0.0 6.0 1.0 1.0 COG0176 Transaldolase/fructose-6-phosphate_aldolase TalA 6.0 0.0 1.0 0.087049766979148 0.235450312612506 0.161250039795827 0.148400545633358 0 0 0 0 K08314 0.0 0.094017094017094 fsaB, talC; fructose-6-phosphate aldolase 2 [EC:4.1.2.-] 210.0 22.0 12.0 3.0 0.647058823529412 G 0.0 34.0 1.0 1.0 COG0176 Transaldolase/fructose-6-phosphate_aldolase TalA 34.0 0.0 1.0 0.0204910788252092 0.152214913976641 0.0863529964009251 0.1317238351514318 0 0 0 0 K08315 0.2314285714285714 0.0626780626780626 hycI; hydrogenase 3 maturation protease [EC:3.4.23.51] 86.0 62.0 19.0 2.0 0.59047619047619 O 82.0 23.0 1.0 1.0 COG0680 Ni,Fe-hydrogenase_maturation_factor HyaD 105.0 0.780952380952381 0.219047619047619 0.250568503412735 0.713395648997117 0.481982076204926 0.462827145584382 0 0 0 0 K08316 0.0057142857142857 0.6638176638176638 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171] 71.0 233.0 230.0 3.0 0.983122362869198 L 2.0 235.0 1.0 1.0 COG0742 16S_rRNA_G966_N2-methylase_RsmD RsmD 237.0 0.0084388185654008 0.9915611814345991 0.0669522235462261 0.195532658238488 0.131242440892357 0.1285804346922619 0 0 0 0 K08317 0.0 0.0142450142450142 hcxA; hydroxycarboxylate dehydrogenase A [EC:1.1.1.-] 354.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG0371 Glycerol_dehydrogenase_or_related_enzyme,_iron-containing_ADH_family GldA 6.0 0.0 1.0 0.022190167334616 8.45688072620684e-05 0.011137368070939 0.0221055985273539 0 0 0 0 K08318 0.0 0.0056980056980056 yihU; 4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase [EC:1.1.1.61 1.1.1.373] path:map00650,path:map01100,path:map01200 Butanoate metabolism,Metabolic pathways,Carbon metabolism 283.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 2.0 0.0 1.0 0 0 0 0 K08319 0.0 0.0541310541310541 ltnD; L-threonate 2-dehydrogenase [EC:1.1.1.411] 286.0 19.0 14.0 2.0 0.791666666666667 I 0.0 24.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 24.0 0.0 1.0 0.006481807963254 0.0207649302081812 0.0136233690857176 0.0142831222449271 0 0 0 0 K08320 0.0057142857142857 0.0199430199430199 nudG; (d)CTP diphosphatase [EC:3.6.1.65] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 110.0 9.0 8.0 2.0 0.9 L 2.0 8.0 2.0 0.9 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 10.0 0.2 0.8 0.147094745337789 0.298954667760288 0.2230247065490385 0.151859922422499 0 0 0 0 K08321 0.0771428571428571 0.0598290598290598 lsrF; 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase [EC:2.3.1.245] path:map02024 Quorum sensing 243.0 31.0 13.0 3.0 0.62 G 27.0 23.0 1.0 1.0 COG1830 Fructose-bisphosphate_aldolase_class_Ia,_DhnA_family FbaB 50.0 0.54 0.46 0.81747696773529 0.652606292489453 0.7350416301123714 0.1648706752458369 1 1 1 1 K08322 0.0 0.0712250712250712 rspB; L-gulonate 5-dehydrogenase [EC:1.1.1.380] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 264.0 21.0 12.0 2.0 0.7 E 0.0 30.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 30.0 0.0 1.0 0.0454271425629646 0.202869783650796 0.1241484631068803 0.1574426410878314 0 0 0 0 K08323 0.0142857142857142 0.0712250712250712 rspA, manD; mannonate dehydratase [EC:4.2.1.8] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 314.0 39.0 0.0 1.0 1.0 M 5.0 34.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 39.0 0.1282051282051282 0.8717948717948718 0.0284648177858883 0.0533576097121395 0.0409112137490139 0.0248927919262512 0 0 0 0 K08324 0.0 0.0199430199430199 sad; succinate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.24] path:map00250,path:map00650,path:map00760,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,Butanoate metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 454.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 8.0 0.0 1.0 0.15086402913437 0.247241228698492 0.199052628916431 0.096377199564122 0 0 0 0 K08325 0.0 0.1339031339031339 yqhD; NADP-dependent alcohol dehydrogenase [EC:1.1.-.-] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 337.0 51.0 0.0 1.0 1.0 C 0.0 51.0 2.0 0.96078431372549 COG1979 Alcohol_dehydrogenase_YqhD,_Fe-dependent_ADH_family YqdH 51.0 0.0 1.0 0.0523115919021605 0.270930641322259 0.1616211166122097 0.2186190494200985 0 0 0 0 K08326 0.0 0.0142450142450142 ypdF; aminopeptidase [EC:3.4.11.-] 353.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0006 Xaa-Pro_aminopeptidase PepP 5.0 0.0 1.0 0.0791065532158141 0.248470008925666 0.16378828107074 0.1693634557098519 0 0 0 0 K08344 0.0 0.0655270655270655 scsB; suppressor for copper-sensitivity B 522.0 27.0 0.0 1.0 1.0 CO 0.0 27.0 2.0 0.962962962962963 COG4232 Thiol:disulfide_interchange_protein_DsbD DsbD 27.0 0.0 1.0 0.0086171463657306 0.0122119230213821 0.0104145346935563 0.0035947766556515 0 0 0 0 K08348 0.0 0.0113960113960113 fdnG; formate dehydrogenase-N, alpha subunit [EC:1.17.5.3] path:map02020 Two-component system 166.0 10.0 0.0 1.0 1.0 C 0.0 10.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 10.0 0.0 1.0 0.0219349724356493 0.0392243514204211 0.0305796619280352 0.0172893789847718 0 0 0 0 K08349 0.0 0.0085470085470085 fdnH; formate dehydrogenase-N, beta subunit path:map02020 Two-component system 291.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 5.0 0.0 1.0 0.0187644169271795 0.0308868977281733 0.0248256573276764 0.0121224808009938 0 0 0 0 K08350 0.0028571428571428 0.0113960113960113 fdnI; formate dehydrogenase-N, gamma subunit path:map02020 Two-component system 192.0 7.0 0.0 1.0 1.0 C 1.0 6.0 1.0 1.0 COG2864 Cytochrome_b_subunit_of_formate_dehydrogenase FdnI 7.0 0.1428571428571428 0.8571428571428571 0.0770680980749365 0.140451983176904 0.1087600406259202 0.0633838851019674 0 0 0 0 K08351 0.0 0.0427350427350427 bisC; biotin/methionine sulfoxide reductase [EC:1.-.-.-] path:map00780,path:map01100 Biotin metabolism,Metabolic pathways 648.0 24.0 0.0 1.0 1.0 C 0.0 24.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 24.0 0.0 1.0 0.0185738814318185 0.0141255010265666 0.0163496912291925 0.0044483804052519 0 0 0 0 K08352 0.0685714285714285 0.1168091168091168 phsA, psrA; thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 286.0 101.0 0.0 1.0 1.0 C 33.0 68.0 3.0 0.97029702970297 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 101.0 0.3267326732673267 0.6732673267326733 0.0233387989038433 0.259798737255851 0.1415687680798471 0.2364599383520077 0 0 0 0 K08353 0.0 0.0227920227920227 phsB; thiosulfate reductase electron transport protein path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 170.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 8.0 0.0 1.0 0.0330392548227616 0.0582970702382746 0.0456681625305181 0.025257815415513 0 0 0 0 K08354 0.0028571428571428 0.0199430199430199 phsC; thiosulfate reductase cytochrome b subunit path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 145.0 8.0 0.0 1.0 1.0 C 1.0 7.0 2.0 0.75 COG4117 Thiosulfate_reductase_cytochrome_b_subunit YdhU 8.0 0.125 0.875 0.127069578129813 0.176736701176906 0.1519031396533595 0.049667123047093 0 0 0 0 K08355 0.02 0.0199430199430199 aoxA; arsenite oxidase small subunit [EC:1.20.2.1 1.20.9.1] 150.0 11.0 8.0 2.0 0.785714285714286 C 7.0 7.0 2.0 0.785714285714286 COG0723 Rieske_Fe-S_protein QcrA/PetC 14.0 0.5 0.5 0.0585724174842723 0.0973662924466488 0.0779693549654605 0.0387938749623765 0 0 0 0 K08356 0.1457142857142857 0.0284900284900284 aoxB; arsenite oxidase large subunit [EC:1.20.2.1 1.20.9.1] 504.0 81.0 0.0 1.0 1.0 C 68.0 13.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 81.0 0.8395061728395061 0.1604938271604938 0.248495671150421 0.0517966441969444 0.1501461576736827 0.1966990269534766 0 0 0 0 K08357 0.0028571428571428 0.0683760683760683 ttrA; tetrathionate reductase subunit A path:map00920,path:map01100,path:map01120,path:map02020 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 509.0 27.0 0.0 1.0 1.0 C 1.0 26.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 27.0 0.037037037037037 0.9629629629629628 0.0284725735213915 0.0503435100261848 0.0394080417737881 0.0218709365047932 0 0 0 0 K08358 0.0314285714285714 0.1025641025641025 ttrB; tetrathionate reductase subunit B path:map00920,path:map01100,path:map01120,path:map02020 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 140.0 58.0 0.0 1.0 1.0 C 12.0 46.0 2.0 0.982758620689655 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 58.0 0.2068965517241379 0.7931034482758621 0.0202282715354688 0.0405115580624658 0.0303699147989673 0.020283286526997 0 0 0 0 K08359 0.0 0.0256410256410256 ttrC; tetrathionate reductase subunit C path:map00920,path:map01100,path:map01120,path:map02020 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Two-component system 317.0 9.0 0.0 1.0 1.0 C 0.0 9.0 1.0 1.0 COG5557 Ni/Fe-hydrogenase_2_integral_membrane_subunit_HybB HybB 9.0 0.0 1.0 0.084214171916778 0.147554008290086 0.115884090103432 0.0633398363733079 0 0 0 0 K08363 0.0514285714285714 0.0712250712250712 merT; mercuric ion transport protein 47.0 27.0 17.0 3.0 0.574468085106383 O 20.0 29.0 8.0 0.551020408163265 COG0425 Sulfur_carrier_protein_TusA_(tRNA_thiolation,_molybdenum_cofactor_biosynthesis) TusA 49.0 0.4081632653061224 0.5918367346938775 0.0561888514190729 0.327362149294944 0.1917755003570084 0.2711732978758711 0 0 0 0 K08364 0.0085714285714285 0.1111111111111111 merP; periplasmic mercuric ion binding protein 54.0 54.0 0.0 1.0 1.0 P 3.0 51.0 1.0 1.0 COG2608 Copper_chaperone_CopZ CopZ 54.0 0.0555555555555555 0.9444444444444444 0.11740707563658 0.0517932426556321 0.084600159146106 0.0656138329809478 0 0 0 0 K08365 0.0 0.0883190883190883 merR; MerR family transcriptional regulator, mercuric resistance operon regulatory protein 115.0 40.0 0.0 1.0 1.0 K 0.0 40.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 40.0 0.0 1.0 0.0171187369504067 0.0201117290221838 0.0186152329862952 0.002992992071777 0 0 0 0 K08368 0.1171428571428571 0.0256410256410256 yaaU; MFS transporter, putative metabolite transport protein 266.0 78.0 47.0 3.0 0.661016949152542 G 101.0 17.0 3.0 0.864406779661017 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 118.0 0.8559322033898306 0.1440677966101695 0.0072416785362111 0.0131784440747712 0.0102100613054911 0.0059367655385601 0 0 0 0 K08369 0.1428571428571428 0.1396011396011396 ydjE; MFS transporter, putative metabolite:H+ symporter 241.0 80.0 15.0 5.0 0.493827160493827 G 92.0 70.0 6.0 0.759259259259259 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 162.0 0.5679012345679012 0.4320987654320987 0.659158584646173 0.484172731680389 0.5716656581632811 0.174985852965784 0 1 0 1 K08372 0.0228571428571428 0.150997150997151 pepD; putative serine protease PepD [EC:3.4.21.-] path:map02020 Two-component system 180.0 83.0 79.0 7.0 0.89247311827957 O 9.0 84.0 7.0 0.924731182795699 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 93.0 0.0967741935483871 0.9032258064516128 0.966044457793126 0.929135351442222 0.947589904617674 0.0369091063509039 1 1 1 1 K08384 0.0 0.2792022792022792 spoVD; stage V sporulation protein D (sporulation-specific penicillin-binding protein) path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 316.0 109.0 108.0 3.0 0.981981981981982 M 0.0 111.0 2.0 0.990990990990991 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 111.0 0.0 1.0 0.979212458704158 0.985140642581059 0.9821765506426086 0.005928183876901 0 0 1 1 K08399 0.0 0.0028490028490028 LGR6; leucine-rich repeat-containing G protein-coupled receptor 6 path:map04310 Wnt signaling pathway 623.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K08466 0.0057142857142857 0.0 ADGRD2, GPR144; adhesion G-protein coupled receptor D2 821.0 2.0 0.0 1.0 1.0 L 2.0 0.0 1.0 1.0 COG0550 DNA_topoisomerase_IA TopA 2.0 1.0 0.0 0 0 0 0 K08475 0.0 0.0056980056980056 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] path:map02020 Two-component system 89.0 2.0 0.0 1.0 1.0 T 0.0 2.0 2.0 0.5 COG4192 Signal_transduction_histidine_kinase_regulating_phosphoglycerate_transport_system 2.0 0.0 1.0 0 0 0 0 K08476 0.0 0.0113960113960113 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA path:map02020 Two-component system 372.0 4.0 0.0 1.0 1.0 T 0.0 4.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 4.0 0.0 1.0 0.0194300010642324 0.0480836396370546 0.0337568203506435 0.0286536385728222 0 0 0 0 K08477 0.0 0.0085470085470085 pgtE; outer membrane protease E [EC:3.4.21.-] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 55.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG4571 Outer_membrane_protease OmpT 3.0 0.0 1.0 0 0 0 0 K08478 0.0 0.0028490028490028 pgtC; phosphoglycerate transport regulatory protein PgtC path:map02020 Two-component system 418.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG1840 ABC-type_Fe3+_transport_system,_periplasmic_component AfuA 1.0 0.0 1.0 0 0 0 0 K08479 0.0 0.0398860398860398 sasA; two-component system, OmpR family, clock-associated histidine kinase SasA [EC:2.7.13.3] path:map02020 Two-component system 354.0 14.0 0.0 1.0 1.0 T 0.0 14.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 14.0 0.0 1.0 2.54380843739241e-13 5.5069763750018e-13 4.025392406197105e-13 2.9631679376093895e-13 0 0 0 0 K08480 0.0 0.0341880341880341 kaiA; circadian clock protein KaiA 111.0 12.0 0.0 1.0 1.0 S 0.0 12.0 1.0 1.0 28IG6 12.0 0.0 1.0 0.0002011539264235 5.0815440505446904e-17 0.0001005769632117 0.0002011539264234 0 0 0 0 K08481 0.0142857142857142 0.074074074074074 kaiB; circadian clock protein KaiB 86.0 49.0 43.0 3.0 0.875 T 10.0 46.0 2.0 0.892857142857143 COG4251 Bacteriophytochrome_(light-regulated_signal_transduction_histidine_kinase) 56.0 0.1785714285714285 0.8214285714285714 0.0007630093000192 0.0019747567839821 0.0013688830420006 0.0012117474839629 0 0 0 0 K08482 0.3857142857142857 0.1481481481481481 kaiC; circadian clock protein KaiC 51.0 294.0 275.0 2.0 0.939297124600639 T 240.0 70.0 2.0 0.996805111821086 COG0467 RecA-superfamily_ATPase,_KaiC/GvpD/RAD55_family RAD55 310.0 0.7741935483870968 0.2258064516129032 0.123653938459523 0.4437508827774 0.2837024106184614 0.320096944317877 0 0 0 0 K08483 0.06 0.5327635327635327 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] path:map02060 Phosphotransferase system (PTS) 308.0 268.0 261.0 3.0 0.971014492753623 G 25.0 251.0 5.0 0.949275362318841 COG1080 Phosphoenolpyruvate-protein_kinase_(PTS_system_EI_component_in_bacteria) PtsA 276.0 0.0905797101449275 0.9094202898550724 0.0113113541903949 0.481387223638894 0.2463492889146444 0.4700758694484991 0 0 0 0 K08484 0.0 0.131054131054131 ptsP; phosphotransferase system, enzyme I, PtsP [EC:2.7.3.9] path:map02060 Phosphotransferase system (PTS) 614.0 49.0 48.0 2.0 0.98 T 0.0 50.0 1.0 1.0 COG3605 Signal_transduction_protein_containing_GAF_and_PtsI_domains PtsP 50.0 0.0 1.0 0.0009415001893005 0.0028563089236334 0.0018989045564669 0.0019148087343328 0 0 0 0 K08485 0.0 0.0398860398860398 ptsO, npr; phosphocarrier protein NPr path:map02060 Phosphotransferase system (PTS) 88.0 14.0 0.0 1.0 1.0 G 0.0 14.0 1.0 1.0 COG1925 HPr_or_related_phosphotransfer_protein PtsH 14.0 0.0 1.0 0.0145623971788887 0.0256809528376476 0.0201216750082681 0.0111185556587589 0 0 0 0 K08566 0.0 0.0142450142450142 pla; plasminogen activator [EC:3.4.23.48] 280.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG4571 Outer_membrane_protease OmpT 5.0 0.0 1.0 0.045429417652693 0.0828737941096528 0.0641516058811729 0.0374443764569598 0 0 0 0 K08568 0.0028571428571428 0.0 CTSZ; cathepsin X [EC:3.4.18.1] path:map04142,path:map04210 Lysosome,Apoptosis 510.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K08571 0.0028571428571428 0.0 E3.4.22.51; cruzipain [EC:3.4.22.51] path:map05142 Chagas disease 715.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K08587 0.0 0.0056980056980056 cloSI; clostripain [EC:3.4.22.8] 373.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG2931 Ca2+-binding_protein,_RTX_toxin-related 2.0 0.0 1.0 0 0 0 0 K08589 0.0057142857142857 0.0085470085470085 rgpA_B; gingipain R [EC:3.4.22.37] path:map01503 Cationic antimicrobial peptide (CAMP) resistance 285.0 8.0 0.0 1.0 1.0 E 5.0 3.0 3.0 0.625 COG2957 Agmatine/peptidylarginine_deiminase AguA 8.0 0.625 0.375 0.0097639443653723 0.055732215834524 0.0327480800999481 0.0459682714691517 0 0 0 0 K08591 0.04 0.717948717948718 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] path:map00561,path:map00564,path:map01100,path:map01110 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 58.0 328.0 315.0 2.0 0.961876832844575 I 18.0 323.0 3.0 0.903225806451613 COG0344 Phospholipid_biosynthesis_protein_PlsY,_probable_glycerol-3-phosphate_acyltransferase PlsY 341.0 0.0527859237536656 0.9472140762463344 0.148872547159589 0.571599712457342 0.3602361298084655 0.422727165297753 0 0 0 0 K08600 0.0 0.0484330484330484 srtB; sortase B [EC:3.4.22.71] 86.0 29.0 27.0 3.0 0.878787878787879 S 0.0 33.0 2.0 0.96969696969697 COG4509 Uncharacterized_conserved_protein 33.0 0.0 1.0 0.0023544127200241 0.0057419738649476 0.0040481932924858 0.0033875611449234 0 0 0 0 K08602 0.2714285714285714 0.3931623931623931 pepF, pepB; oligoendopeptidase F [EC:3.4.24.-] 227.0 278.0 0.0 1.0 1.0 E 110.0 168.0 1.0 1.0 COG1164 Oligoendopeptidase_F PepF 278.0 0.39568345323741 0.60431654676259 0.136845038907818 0.557408788189614 0.347126913548716 0.4205637492817961 0 0 0 0 K08603 0.0 0.0085470085470085 npr; thermolysin [EC:3.4.24.27] 484.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 5.0 0.0 1.0 0.0293840929839669 0.079214575480635 0.0542993342323009 0.0498304824966681 0 0 0 0 K08604 0.0 0.0142450142450142 hap, nprV; vibriolysin [EC:3.4.24.25] path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 211.0 3.0 2.0 4.0 0.5 E 0.0 6.0 3.0 0.666666666666667 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 6.0 0.0 1.0 8.70194731348564e-12 0.158124128358759 0.0790620641837304 0.158124128350057 0 0 0 0 K08605 0.0028571428571428 0.0056980056980056 gelE; coccolysin [EC:3.4.24.30] path:map02024 Quorum sensing 286.0 3.0 0.0 1.0 1.0 E 1.0 2.0 1.0 1.0 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K08640 0.0 0.0284900284900284 E3.4.17.14; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] 198.0 10.0 8.0 2.0 0.833333333333333 M 0.0 12.0 2.0 0.583333333333333 COG3108 Uncharacterized_conserved_protein_YcbK,_DUF882_family YcbK 12.0 0.0 1.0 0.0409943065391198 0.0304749602854998 0.0357346334123098 0.0105193462536199 0 0 0 0 K08641 0.0085714285714285 0.2592592592592592 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] path:map01502,path:map02020 Vancomycin resistance,Two-component system 52.0 87.0 77.0 4.0 0.813084112149533 M 3.0 111.0 7.0 0.833333333333333 COG2173 D-alanyl-D-alanine_dipeptidase DdpX 114.0 0.0263157894736842 0.9736842105263158 0.0152764842263914 0.509424139190966 0.2623503117086787 0.4941476549645746 0 0 0 0 K08642 0.0028571428571428 0.0256410256410256 lasA; LasA protease [EC:3.4.24.-] path:map02024 Quorum sensing 106.0 12.0 0.0 1.0 1.0 M 1.0 11.0 1.0 1.0 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 12.0 0.0833333333333333 0.9166666666666666 0.0310790387307618 0.223953841514415 0.1275164401225884 0.1928748027836532 0 0 0 0 K08643 0.0 0.0085470085470085 zmpB; zinc metalloprotease ZmpB [EC:3.4.24.-] 12.0 2.0 1.0 3.0 0.5 M 0.0 4.0 3.0 0.5 COG3064 Membrane_protein_TolA_involved_in_colicin_uptake TolA 4.0 0.0 1.0 5.23192461968505e-12 0.0856423999760038 0.0428211999906178 0.0856423999707718 0 0 0 0 K08646 0.0 0.0085470085470085 MEP; peptidyl-Lys metalloendopeptidase [EC:3.4.24.20] 92.0 2.0 1.0 3.0 0.5 T 0.0 4.0 2.0 0.75 COG4104 Zn-binding_Pro-Ala-Ala-Arg_(PAAR)_domain,_involved_in_Type_VI_secretion PAAR 4.0 0.0 1.0 0.0106282928383773 0.0263360684820136 0.0184821806601954 0.0157077756436362 0 0 0 0 K08651 0.0228571428571428 0.0968660968660968 E3.4.21.66; thermitase [EC:3.4.21.66] 117.0 61.0 59.0 4.0 0.938461538461538 O 9.0 56.0 3.0 0.953846153846154 COG1404 Serine_protease,_subtilisin_family AprE 65.0 0.1384615384615384 0.8615384615384616 0.0184763252649381 0.0480304010164278 0.0332533631406829 0.0295540757514896 0 0 0 0 K08652 0.0057142857142857 0.0199430199430199 C5AP, scpA, scpB; C5a peptidase [EC:3.4.21.110] 504.0 15.0 13.0 3.0 0.833333333333333 O 2.0 16.0 2.0 0.944444444444444 COG1404 Serine_protease,_subtilisin_family AprE 18.0 0.1111111111111111 0.8888888888888888 0.0119919193108993 0.0286589740837325 0.0203254466973159 0.0166670547728332 0 0 0 0 K08653 0.0142857142857142 0.0 MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112] path:map04141 Protein processing in endoplasmic reticulum 706.0 7.0 0.0 1.0 1.0 O 7.0 0.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 7.0 1.0 0.0 0.44005826875135 0.879807878452905 0.6599330736021275 0.4397496097015549 0 0 0 0 K08659 0.0028571428571428 0.037037037037037 pepDA, pepDB; dipeptidase [EC:3.4.-.-] 412.0 15.0 0.0 1.0 1.0 E 1.0 14.0 1.0 1.0 COG4690 Dipeptidase PepD 15.0 0.0666666666666666 0.9333333333333332 0.0448854761562882 0.0816412204586207 0.0632633483074544 0.0367557443023325 0 0 0 0 K08660 0.0 0.0028490028490028 CNDP2; cytosolic nonspecific dipeptidase [EC:3.4.13.18] path:map00330,path:map00340,path:map00410,path:map01100 Arginine and proline metabolism,Histidine metabolism,beta-Alanine metabolism,Metabolic pathways 469.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 1.0 0.0 1.0 0 0 0 0 K08675 0.0 0.0113960113960113 PRSS15, PIM1; ATP-dependent Lon protease [EC:3.4.21.53] 116.0 4.0 0.0 1.0 1.0 O 0.0 4.0 1.0 1.0 COG0466 ATP-dependent_Lon_protease,_bacterial_type Lon 4.0 0.0 1.0 0.161626964829232 0.297741561619668 0.22968426322445 0.136114596790436 0 0 0 0 K08676 0.0428571428571428 0.1424501424501424 tri; tricorn protease [EC:3.4.21.-] 574.0 72.0 54.0 3.0 0.782608695652174 M 17.0 75.0 3.0 0.804347826086957 COG0793 C-terminal_processing_protease_CtpA/Prc,_contains_a_PDZ_domain CtpA 92.0 0.1847826086956521 0.8152173913043478 0.121558840246732 0.115663321018577 0.1186110806326544 0.0058955192281549 0 0 0 0 K08677 0.0114285714285714 0.0484330484330484 K08677; kumamolisin 328.0 39.0 0.0 1.0 1.0 O 4.0 35.0 3.0 0.923076923076923 COG4934 Serine_protease,_subtilase_family 39.0 0.1025641025641025 0.8974358974358975 0.0135800015970716 0.106519618658902 0.0600498101279868 0.0929396170618304 0 0 0 0 K08678 0.2885714285714286 0.3076923076923077 UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 165.0 145.0 47.0 3.0 0.587044534412955 M 120.0 127.0 3.0 0.983805668016194 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 247.0 0.48582995951417 0.5141700404858299 0.919467888640834 0.970571692323939 0.9450197904823864 0.051103803683105 1 1 1 1 K08679 0.0828571428571428 0.4928774928774929 GAE, cap1J; UDP-glucuronate 4-epimerase [EC:5.1.3.6] path:map00053,path:map00520,path:map00541,path:map01100,path:map01240,path:map01250 Ascorbate and aldarate metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Biosynthesis of nucleotide sugars 247.0 209.0 195.0 2.0 0.937219730941704 M 29.0 194.0 2.0 0.928251121076233 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 223.0 0.1300448430493273 0.8699551569506726 0.57188485618634 0.844880723418505 0.7083827898024224 0.2729958672321649 0 1 0 1 K08680 0.0142857142857142 0.150997150997151 menH; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [EC:4.2.99.20] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 107.0 43.0 33.0 4.0 0.671875 I 5.0 59.0 4.0 0.671875 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 64.0 0.078125 0.921875 0.0032681240901954 0.707429682191604 0.3553489031408997 0.7041615581014086 0 0 0 0 K08681 0.5457142857142857 0.2849002849002849 pdxT, pdx2; pyridoxal 5'-phosphate synthase pdxT subunit [EC:4.3.3.6] path:map00750,path:map01100,path:map01240 Vitamin B6 metabolism,Metabolic pathways,Biosynthesis of cofactors 125.0 270.0 248.0 2.0 0.924657534246575 H 192.0 100.0 1.0 1.0 COG0311 Pyridoxal_5'-phosphate_synthase_subunit_PdxT_(glutamine_amidotransferase) PdxT 292.0 0.6575342465753424 0.3424657534246575 0.983008628176179 0.90992754303424 0.9464680856052096 0.073081085141939 1 1 1 1 K08682 0.0 0.0284900284900284 acpH; acyl carrier protein phosphodiesterase [EC:3.1.4.14] path:map00770,path:map01100 Pantothenate and CoA biosynthesis,Metabolic pathways 182.0 9.0 8.0 2.0 0.9 S 0.0 10.0 1.0 1.0 COG3124 Acyl_carrier_protein_phosphodiesterase AcpH 10.0 0.0 1.0 0.0276510271194995 0.0682796934744233 0.0479653602969614 0.0406286663549237 0 0 0 0 K08683 0.0 0.0028490028490028 HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] path:map00280,path:map01100,path:map01110,path:map05010,path:map05022 Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Alzheimer disease,Pathways of neurodegeneration - multiple diseases 260.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 KOG1199 1.0 0.0 1.0 0 0 0 0 K08685 0.0 0.0085470085470085 qhpA; quinohemoprotein amine dehydrogenase [EC:1.4.9.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 305.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 3.0 0.0 1.0 0 0 0 0 K08687 0.0 0.0085470085470085 E3.5.1.59; N-carbamoylsarcosine amidase [EC:3.5.1.59] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 224.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1335 Nicotinamidase-related_amidase PncA 3.0 0.0 1.0 0 0 0 0 K08688 0.0171428571428571 0.0398860398860398 E3.5.3.3; creatinase [EC:3.5.3.3] path:map00260,path:map00330,path:map01100 Glycine, serine and threonine metabolism,Arginine and proline metabolism,Metabolic pathways 337.0 22.0 0.0 1.0 1.0 E 6.0 16.0 1.0 1.0 COG0006 Xaa-Pro_aminopeptidase PepP 22.0 0.2727272727272727 0.7272727272727273 0.0315295056236126 0.0894156201308084 0.0604725628772104 0.0578861145071957 0 0 0 0 K08689 0.0 0.0142450142450142 bphAa, bphA1, bphA; biphenyl 2,3-dioxygenase subunit alpha [EC:1.14.12.18] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 400.0 5.0 0.0 1.0 1.0 P 0.0 5.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 5.0 0.0 1.0 0.128440416573962 0.265412388799284 0.196926402686623 0.136971972225322 0 0 0 0 K08690 0.0057142857142857 0.0 bphB; cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 250.0 2.0 0.0 1.0 1.0 IQ 2.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 1.0 0.0 0 0 0 0 K08691 0.0 0.0826210826210826 mcl; malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25] path:map00630,path:map00660,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 288.0 35.0 32.0 3.0 0.897435897435897 G 0.0 39.0 1.0 1.0 COG2301 Citrate_lyase_beta_subunit CitE 39.0 0.0 1.0 0.0124903222501122 0.345709403319765 0.1790998627849386 0.3332190810696528 0 0 0 0 K08692 0.0028571428571428 0.0227920227920227 mtkB; malate-CoA ligase subunit alpha [EC:6.2.1.9] path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 291.0 5.0 0.0 3.0 0.454545454545455 H 1.0 10.0 1.0 1.0 COG0074 Succinyl-CoA_synthetase,_alpha_subunit SucD 11.0 0.0909090909090909 0.9090909090909092 0.0454327068041788 0.1016242271571 0.0735284669806394 0.0561915203529211 0 0 0 0 K08693 0.0028571428571428 0.0455840455840455 yfkN; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5] path:map00230,path:map00240,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 283.0 23.0 21.0 3.0 0.884615384615385 F 1.0 25.0 2.0 0.961538461538462 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 26.0 0.0384615384615384 0.9615384615384616 0.0217303242569688 0.0408730932367709 0.0313017087468698 0.0191427689798021 0 0 0 0 K08696 0.0 0.037037037037037 ccmK; carbon dioxide concentrating mechanism protein CcmK 96.0 31.0 0.0 1.0 1.0 CQ 0.0 31.0 1.0 1.0 COG4577 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmL/EutN CcmK 31.0 0.0 1.0 0.0020059244301276 0.0047076970059689 0.0033568107180482 0.0027017725758413 0 0 0 0 K08697 0.0028571428571428 0.0398860398860398 ccmL; carbon dioxide concentrating mechanism protein CcmL 94.0 15.0 0.0 1.0 1.0 CQ 1.0 14.0 1.0 1.0 COG4576 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmK/EutM CcmL 15.0 0.0666666666666666 0.9333333333333332 0.0004089734964377 0.0007764988566607 0.0005927361765492 0.000367525360223 0 0 0 0 K08698 0.0114285714285714 0.037037037037037 ccmM; carbon dioxide concentrating mechanism protein CcmM 199.0 13.0 7.0 2.0 0.68421052631579 C 6.0 13.0 1.0 1.0 COG0663 Carbonic_anhydrase_or_acetyltransferase,_isoleucine_patch_superfamily PaaY 19.0 0.3157894736842105 0.6842105263157895 0.0054700477761444 0.0103047757342462 0.0078874117551953 0.0048347279581018 0 0 0 0 K08699 0.0 0.037037037037037 ccmN; carbon dioxide concentrating mechanism protein CcmN 151.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG0663 Carbonic_anhydrase_or_acetyltransferase,_isoleucine_patch_superfamily PaaY 13.0 0.0 1.0 1.6064514830190098e-11 0.000890586415045 0.0004452932155547 0.0008905863989804 0 0 0 0 K08700 0.0 0.0398860398860398 ccmO; carbon dioxide concentrating mechanism protein CcmO 228.0 14.0 0.0 1.0 1.0 CQ 0.0 14.0 1.0 1.0 COG4577 Carboxysome_shell_and_ethanolamine_utilization_microcompartment_protein_CcmL/EutN CcmK 14.0 0.0 1.0 0.0011605799630844 0.0023477084148298 0.0017541441889571 0.0011871284517454 0 0 0 0 K08707 0.0028571428571428 0.0 DNTTIP1; deoxynucleotidyltransferase terminal-interacting protein 1 186.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 1.0 1.0 0.0 0 0 0 0 K08713 0.0 0.0113960113960113 lctB; potassium channel LctB 120.0 6.0 0.0 1.0 1.0 P 0.0 6.0 1.0 1.0 COG1226 Voltage-gated_potassium_channel_Kch Kch 6.0 0.0 1.0 7.97381920789905e-06 9.31282366112305e-05 5.055102790956477e-05 8.515441740333144e-05 0 0 0 0 K08714 0.0114285714285714 0.1025641025641025 VGSC; voltage-gated sodium channel 206.0 39.0 36.0 4.0 0.886363636363636 P 4.0 40.0 3.0 0.909090909090909 COG1226 Voltage-gated_potassium_channel_Kch Kch 44.0 0.0909090909090909 0.9090909090909092 0.0115624956030435 0.0199994394448377 0.0157809675239406 0.0084369438417942 0 0 0 0 K08715 0.0 0.0541310541310541 IRPC; inward rectifier potassium channel 249.0 17.0 16.0 4.0 0.85 G 0.0 20.0 2.0 0.9 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 20.0 0.0 1.0 0.0397377571751669 0.0704894657356559 0.0551136114554113 0.0307517085604889 0 0 0 0 K08717 0.0114285714285714 0.0313390313390313 utp; urea transporter 264.0 13.0 12.0 3.0 0.866666666666667 E 4.0 11.0 2.0 0.933333333333333 COG4413 Urea_transporter Utp 15.0 0.2666666666666666 0.7333333333333333 0.0860719588679664 0.245667274061096 0.1658696164645312 0.1595953151931296 0 0 0 0 K08720 0.0 0.0484330484330484 ompU; outer membrane protein OmpU path:map01501,path:map05111 beta-Lactam resistance,Biofilm formation - Vibrio cholerae 167.0 37.0 0.0 1.0 1.0 M 0.0 37.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 37.0 0.0 1.0 0.000726774417993 0.0013573046683492 0.0010420395431711 0.0006305302503561 0 0 0 0 K08721 0.0 0.0113960113960113 oprJ; outer membrane protein, multidrug efflux system 416.0 3.0 2.0 2.0 0.75 M 0.0 4.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 4.0 0.0 1.0 0.106319219755664 0.194992829800318 0.150656024777991 0.088673610044654 0 0 0 0 K08722 0.0 0.0541310541310541 yfbR; 5'-deoxynucleotidase [EC:3.1.3.89] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 187.0 18.0 17.0 2.0 0.947368421052632 S 0.0 19.0 1.0 1.0 COG1896 5'-deoxynucleotidase_YfbR_and_related_HD_superfamily_hydrolases YfbR 19.0 0.0 1.0 0.0160478327605049 0.0448798669019529 0.0304638498312289 0.028832034141448 0 0 0 0 K08723 0.0285714285714285 0.0826210826210826 yjjG; pyrimidine 5'-nucleotidase [EC:3.1.3.-] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 95.0 41.0 40.0 3.0 0.953488372093023 S 11.0 32.0 2.0 0.953488372093023 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 43.0 0.2558139534883721 0.7441860465116279 0.23141261676283 0.978777515518297 0.6050950661405635 0.747364898755467 0 0 0 0 K08724 0.0 0.1082621082621082 pbpB; penicillin-binding protein 2B path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 370.0 37.0 36.0 2.0 0.973684210526316 M 0.0 38.0 2.0 0.973684210526316 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 38.0 0.0 1.0 0.225332741478093 0.018969752401952 0.1221512469400225 0.206362989076141 0 0 0 0 K08726 0.0028571428571428 0.0056980056980056 EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76] path:map00590,path:map00625,path:map01100,path:map01120,path:map04146,path:map05207,path:map05208 Arachidonic acid metabolism,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Peroxisome,Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species 129.0 3.0 0.0 1.0 1.0 I 1.0 2.0 1.0 1.0 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K08728 0.0914285714285714 0.0142450142450142 E2.4.2.6; nucleoside deoxyribosyltransferase [EC:2.4.2.6] 95.0 39.0 0.0 1.0 1.0 F 33.0 6.0 2.0 0.974358974358975 COG3613 Nucleoside_2-deoxyribosyltransferase RCL 39.0 0.8461538461538461 0.1538461538461538 0.0696150071130678 0.0590645790088314 0.0643397930609496 0.0105504281042363 0 0 0 0 K08738 0.0 0.0 CYC; cytochrome c path:map00190,path:map01100,path:map01524,path:map02020,path:map04115,path:map04210,path:map04214,path:map04215,path:map04932,path:map05010,path:map05012,path:map05014,path:map05016,path:map05017,path:map05020,path:map05022,path:map05130,path:map05131,path:map05132,path:map05134,path:map05145,path:map05152,path:map05160,path:map05161,path:map05162,path:map05163,path:map05164,path:map05167,path:map05168,path:map05169,path:map05170,path:map05200,path:map05210,path:map05222,path:map05416,path:map05417 Oxidative phosphorylation,Metabolic pathways,Platinum drug resistance,Two-component system,p53 signaling pathway,Apoptosis,Apoptosis - fly,Apoptosis - multiple species,Non-alcoholic fatty liver disease,Alzheimer disease,Parkinson disease,Amyotrophic lateral sclerosis,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection,Legionellosis,Toxoplasmosis,Tuberculosis,Hepatitis C,Hepatitis B,Measles,Human cytomegalovirus infection,Influenza A,Kaposi sarcoma-associated herpesvirus infection,Herpes simplex virus 1 infection,Epstein-Barr virus infection,Human immunodeficiency virus 1 infection,Pathways in cancer,Colorectal cancer,Small cell lung cancer,Viral myocarditis,Lipid and atherosclerosis 241.0 228.0 8.0 0.87956204379562 C 0.0 0.0 16.0 0.394160583941606 COG3474 Cytochrome_c2 Cyc7 0.0 0 0 0 0 K08739 0.0028571428571428 0.0 MLH3; DNA mismatch repair protein MLH3 path:map03430 Mismatch repair 91.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 KOG3360 1.0 1.0 0.0 0 0 0 0 K08744 0.02 0.5441595441595442 CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 70.0 259.0 257.0 2.0 0.992337164750958 I 8.0 253.0 3.0 0.992337164750958 COG0558 Phosphatidylglycerophosphate_synthase PgsA 261.0 0.0306513409961685 0.9693486590038314 0.200736545831686 0.352033770911264 0.276385158371475 0.151297225079578 0 0 0 0 K08762 0.0028571428571428 0.0 DBI, ACBP; diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) path:map03320 PPAR signaling pathway 90.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG4281 Acyl-CoA-binding_protein ACB 1.0 1.0 0.0 0 0 0 0 K08765 0.0 0.0085470085470085 CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21] path:map00071,path:map01212,path:map03320,path:map04152,path:map04714,path:map04920,path:map04922,path:map04931,path:map04936 Fatty acid degradation,Fatty acid metabolism,PPAR signaling pathway,AMPK signaling pathway,Thermogenesis,Adipocytokine signaling pathway,Glucagon signaling pathway,Insulin resistance,Alcoholic liver disease 527.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 28HC8 3.0 0.0 1.0 0 0 0 0 K08770 0.0085714285714285 0.0028490028490028 UBC; ubiquitin C path:map03320,path:map04120,path:map04137,path:map05012,path:map05022,path:map05131,path:map05167 PPAR signaling pathway,Ubiquitin mediated proteolysis,Mitophagy - animal,Parkinson disease,Pathways of neurodegeneration - multiple diseases,Shigellosis,Kaposi sarcoma-associated herpesvirus infection 56.0 4.0 0.0 1.0 1.0 O 3.0 1.0 2.0 0.75 COG5272 Ubiquitin UBI4 4.0 0.75 0.25 0.224752290486708 0.592860341649816 0.408806316068262 0.3681080511631081 0 0 0 0 K08776 0.0057142857142857 0.1339031339031339 NPEPPS; puromycin-sensitive aminopeptidase [EC:3.4.11.14] 558.0 59.0 56.0 4.0 0.907692307692308 E 2.0 63.0 2.0 0.969230769230769 COG0308 Aminopeptidase_N,_contains_DUF3458_domain PepN 65.0 0.0307692307692307 0.9692307692307692 0.0143453365871691 0.2985976830315 0.1564715098093345 0.2842523464443309 0 0 0 0 K08777 0.0 0.0142450142450142 nprB; neutral peptidase B [EC:3.4.24.-] path:map02024 Quorum sensing 147.0 3.0 1.0 3.0 0.5 E 0.0 6.0 2.0 0.5 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 6.0 0.0 1.0 7.00212263282485e-12 0.119279822562914 0.059639911284958 0.1192798225559118 0 0 0 0 K08794 0.0 0.0028490028490028 CAMK1; calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] path:map04020,path:map04921,path:map04925,path:map05214 Calcium signaling pathway,Oxytocin signaling pathway,Aldosterone synthesis and secretion,Glioma 365.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG0032 1.0 0.0 1.0 0 0 0 0 K08838 0.0 0.0028490028490028 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1] 598.0 1.0 0.0 1.0 1.0 KLT 0.0 1.0 1.0 1.0 COG0515 Serine/threonine_protein_kinase SPS1 1.0 0.0 1.0 0 0 0 0 K08851 0.6057142857142858 0.0 TP53RK, PRPK, BUD32; TP53 regulating kinase and related kinases [EC:2.7.11.1] 123.0 192.0 164.0 3.0 0.857142857142857 T 224.0 0.0 2.0 0.955357142857143 COG0533 tRNA_A37_threonylcarbamoyltransferase_TsaD TsaD 224.0 1.0 0.0 0.684439499444432 0.600383333856486 0.6424114166504591 0.084056165587946 0 0 0 1 K08857 0.0 0.0028490028490028 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 455.0 1.0 0.0 2.0 0.5 O 0.0 2.0 2.0 0.5 KOG0591 2.0 0.0 1.0 0 0 0 0 K08878 0.0028571428571428 0.0 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1] path:map05200,path:map05220 Pathways in cancer,Chronic myeloid leukemia 204.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG0094 1.0 1.0 0.0 0 0 0 0 K08884 0.06 0.4586894586894587 K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] 7.0 546.0 508.0 15.0 0.806499261447563 KLT 26.0 590.0 22.0 0.808823529411765 COG0515 Serine/threonine_protein_kinase SPS1 616.0 0.0422077922077922 0.9577922077922078 0 0 0 0 K08900 0.0 0.0085470085470085 BCS1; mitochondrial chaperone BCS1 88.0 4.0 0.0 1.0 1.0 O 0.0 4.0 1.0 1.0 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 4.0 0.0 1.0 9.57987761866219e-12 1.78721931463778e-11 1.3726035382519992e-11 8.292315527715609e-12 0 0 0 0 K08902 0.0 0.037037037037037 psb27; photosystem II Psb27 protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 132.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 2AMT1 13.0 0.0 1.0 0.0002299285621766 0.0003288986971701 0.0002794136296733 9.897013499350004e-05 0 0 0 0 K08903 0.0 0.0398860398860398 psb28; photosystem II 13kDa protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 111.0 13.0 12.0 2.0 0.928571428571429 S 0.0 14.0 2.0 0.785714285714286 2AR4E 14.0 0.0 1.0 0.000569585830239 0.0005227525240926 0.0005461691771658 4.683330614640004e-05 0 0 0 0 K08904 0.0 0.0199430199430199 psb28-2; photosystem II Psb28-2 protein path:map00195,path:map01100 Photosynthesis,Metabolic pathways 117.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3310 Uncharacterized_conserved_protein,_DUF1415_family 7.0 0.0 1.0 0.0032582258397183 0.0019451053108553 0.0026016655752868 0.001313120528863 0 0 0 0 K08906 0.0 0.0541310541310541 petJ; cytochrome c6 path:map00195,path:map01100 Photosynthesis,Metabolic pathways 96.0 32.0 0.0 1.0 1.0 C 0.0 32.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 32.0 0.0 1.0 0.0050816886993419 0.0091943772128106 0.0071380329560762 0.0041126885134687 0 0 0 0 K08918 0.0 0.0056980056980056 pcbA; chlorophyll a/b binding light-harvesting protein PcbA 335.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2EXJ5 4.0 0.0 1.0 1.33513102357286e-05 0.0002246519149869 0.0001190016126113 0.0002113006047511 0 0 0 0 K08920 0.0 0.0056980056980056 pcbC; chlorophyll a/b binding light-harvesting protein PcbC 335.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2EXJ5 3.0 0.0 1.0 0 0 0 0 K08921 0.0 0.0056980056980056 pcbD; chlorophyll a/b binding light-harvesting protein PcbD 335.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2EXJ5 4.0 0.0 1.0 1.33513102357286e-05 0.0002246519149869 0.0001190016126113 0.0002113006047511 0 0 0 0 K08926 0.0 0.0199430199430199 pufA; light-harvesting complex 1 alpha chain path:map02020 Two-component system 43.0 9.0 7.0 2.0 0.818181818181818 C 0.0 11.0 3.0 0.636363636363636 2EI15 11.0 0.0 1.0 0.0360849192452469 0.0403563324687039 0.0382206258569754 0.0042714132234569 0 0 0 0 K08927 0.0 0.0256410256410256 pufB; light-harvesting complex 1 beta chain path:map02020 Two-component system 44.0 14.0 12.0 2.0 0.875 C 0.0 17.0 6.0 0.352941176470588 2DPVW 17.0 0.0 1.0 0.021003646561435 0.0326013673650689 0.0268025069632519 0.0115977208036338 0 0 0 0 K08928 0.0 0.037037037037037 pufL; photosynthetic reaction center L subunit path:map02020 Two-component system 267.0 8.0 1.0 2.0 0.533333333333333 S 0.0 15.0 2.0 0.666666666666667 2DB77 15.0 0.0 1.0 0.0639036199957996 0.105915727051537 0.0849096735236683 0.0420121070557373 0 0 0 0 K08929 0.0 0.037037037037037 pufM; photosynthetic reaction center M subunit path:map02020 Two-component system 290.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 2DBBD 13.0 0.0 1.0 0.0955968650270387 0.1836120369444 0.1396044509857193 0.0880151719173613 0 0 0 0 K08930 0.0 0.017094017094017 pucA; light-harvesting protein B-800-850 alpha chain path:map02020 Two-component system 44.0 12.0 10.0 2.0 0.857142857142857 C 0.0 14.0 3.0 0.714285714285714 2EKTS 14.0 0.0 1.0 0.0118895668498167 0.0193718074882762 0.0156306871690464 0.0074822406384594 0 0 0 0 K08939 0.0 0.0085470085470085 pucB; light-harvesting protein B-800-850 beta chain path:map02020 Two-component system 40.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 2DPFA 8.0 0.0 1.0 0.0052682814320823 0.0083440488324123 0.0068061651322473 0.00307576740033 0 0 0 0 K08940 0.0 0.0085470085470085 pscA; photosystem P840 reaction center large subunit 731.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2BXRG 3.0 0.0 1.0 0 0 0 0 K08941 0.0085714285714285 0.0427350427350427 pscB; photosystem P840 reaction center iron-sulfur protein 250.0 24.0 0.0 1.0 1.0 C 3.0 18.0 2.0 0.75 COG4231 TPP-dependent_indolepyruvate_ferredoxin_oxidoreductase,_alpha_subunit IorA 21.0 0.1428571428571428 0.8571428571428571 0.0448149069333536 0.166579116381391 0.1056970116573723 0.1217642094480374 0 0 0 0 K08942 0.0 0.0113960113960113 pscC; photosystem P840 reaction center cytochrome c551 84.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG3245 Cytochrome_c5 CytC5 5.0 0.0 1.0 1.60509175408359e-07 6.60118440699955e-06 3.3808467912039544e-06 6.440675231591191e-06 0 0 0 0 K08943 0.0 0.0085470085470085 pscD; photosystem P840 reaction center protein PscD 125.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2EEXE 3.0 0.0 1.0 0 0 0 0 K08944 0.0 0.0085470085470085 fmoA; bacteriochlorophyll A protein 366.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 28M6S 3.0 0.0 1.0 0 0 0 0 K08945 0.0 0.0085470085470085 csmA; chlorosome envelope protein A 80.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 2D9MW 3.0 0.0 1.0 0 0 0 0 K08946 0.0 0.0085470085470085 csmB; chlorosome envelope protein B 73.0 0.0 6.0 1.0 1.0 2FHZI 6.0 0.0 1.0 0 0 0 0 K08947 0.0 0.0085470085470085 csmC; chlorosome envelope protein C 139.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2DBCQ 3.0 0.0 1.0 0 0 0 0 K08949 0.0 0.0085470085470085 csmE; chlorosome envelope protein E 83.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2D9MW 3.0 0.0 1.0 0 0 0 0 K08950 0.0 0.0085470085470085 csmF; chlorosome envelope protein F 74.0 0.0 3.0 1.0 1.0 2EQ1B 3.0 0.0 1.0 0 0 0 0 K08951 0.0 0.0085470085470085 csmH; chlorosome envelope protein H 162.0 2.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 2F5CQ 3.0 0.0 1.0 0 0 0 0 K08952 0.0 0.0313390313390313 csmI; chlorosome envelope protein I 81.0 16.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG0633 Ferredoxin Fdx 15.0 0.0 1.0 0.682191657219423 0.0688751165835159 0.3755333869014694 0.6133165406359071 0 0 0 1 K08953 0.0 0.0313390313390313 csmJ; chlorosome envelope protein J 73.0 13.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG0633 Ferredoxin Fdx 12.0 0.0 1.0 0.898776069869257 0.1360842813739 0.5174301756215784 0.762691788495357 0 0 1 1 K08954 0.0 0.0313390313390313 csmX; chlorosome envelope protein X 79.0 13.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG0633 Ferredoxin Fdx 12.0 0.0 1.0 0.892587327261676 0.0894189094942942 0.4910031183779851 0.8031684177673818 0 0 1 1 K08955 0.0028571428571428 0.0 YME1; ATP-dependent metalloprotease [EC:3.4.24.-] path:map04139 Mitophagy - yeast 258.0 1.0 0.0 1.0 1.0 IQ 1.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 1.0 0.0 0 0 0 0 K08961 0.0 0.017094017094017 K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21] 244.0 2.0 1.0 5.0 0.333333333333333 UW 0.0 6.0 4.0 0.333333333333333 COG1404 Serine_protease,_subtilisin_family AprE 6.0 0.0 1.0 0.804445991453064 0.158934825922335 0.4816904086876994 0.645511165530729 0 0 1 1 K08963 0.54 0.50997150997151 mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 186.0 342.0 297.0 3.0 0.879177377892031 J 205.0 192.0 3.0 0.974811083123426 COG0182 5-methylthioribose/5-deoxyribulose_1-phosphate_isomerase_(methionine_salvage_pathway),_a_paralog_of_eIF-2B_alpha_subunit MtnA 397.0 0.5163727959697733 0.4836272040302267 0.885178829057024 0.837191763002789 0.8611852960299065 0.047987066054235 1 1 1 1 K08964 0.0114285714285714 0.1054131054131054 mtnB; methylthioribulose-1-phosphate dehydratase [EC:4.2.1.109] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 153.0 32.0 24.0 3.0 0.744186046511628 E 4.0 39.0 2.0 0.930232558139535 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 43.0 0.0930232558139534 0.9069767441860463 0.0503851739698474 0.183321644286145 0.1168534091279962 0.1329364703162976 0 0 0 0 K08965 0.0885714285714285 0.0455840455840455 mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [EC:5.3.2.5] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 328.0 48.0 47.0 2.0 0.979591836734694 G 32.0 17.0 1.0 1.0 COG1850 Ribulose_1,5-bisphosphate_carboxylase,_large_subunit,_or_a_RuBisCO-like_protein RbcL 49.0 0.6530612244897959 0.3469387755102041 0.627336444320469 0.918146921615036 0.7727416829677525 0.290810477294567 0 1 0 1 K08966 0.0085714285714285 0.0484330484330484 mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [EC:3.1.3.87] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 155.0 24.0 0.0 1.0 1.0 E 3.0 21.0 2.0 0.833333333333333 COG4359 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate_phosphatase_(methionine_salvage) MtnX 24.0 0.125 0.875 0.258680854949984 0.8462823429711 0.552481598960542 0.587601488021116 0 0 0 0 K08967 0.0085714285714285 0.1025641025641025 mtnD, mtnZ, ADI1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [EC:1.13.11.53 1.13.11.54] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 145.0 36.0 33.0 4.0 0.878048780487805 S 3.0 38.0 1.0 1.0 COG1791 Acireductone_dioxygenase_(methionine_salvage),_cupin_superfamily Adi1 41.0 0.073170731707317 0.926829268292683 0.0081003373496017 0.0276062164754385 0.0178532769125201 0.0195058791258368 0 0 0 0 K08968 0.0742857142857142 0.2621082621082621 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 104.0 127.0 0.0 1.0 1.0 T 29.0 98.0 4.0 0.94488188976378 COG1956 GAF_domain-containing_protein,_putative_methionine-R-sulfoxide_reductase MsrC 127.0 0.2283464566929134 0.7716535433070866 0.237493287223323 0.319507798866945 0.278500543045134 0.082014511643622 0 0 0 0 K08969 0.0028571428571428 0.0427350427350427 mtnE, mtnV; L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase [EC:2.6.1.117] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 373.0 16.0 0.0 1.0 1.0 E 1.0 15.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 16.0 0.0625 0.9375 0.0268043260647954 0.0201531612380324 0.0234787436514139 0.006651164826763 0 0 0 0 K08970 0.0 0.0683760683760683 rcnA; nickel/cobalt transporter (NicO) family protein 176.0 12.0 6.0 4.0 0.461538461538462 P 0.0 26.0 2.0 0.961538461538462 COG2215 ABC-type_nickel/cobalt_efflux_system,_permease_component_RcnA RcnA 26.0 0.0 1.0 0.0471613254691049 0.250307818281953 0.1487345718755289 0.203146492812848 0 0 0 0 K08971 0.5485714285714286 0.0 K08971; putative membrane protein 298.0 201.0 0.0 1.0 1.0 S 201.0 0.0 1.0 1.0 COG1784 TctA_family_transporter 201.0 1.0 0.0 0.0953770476247429 0.494263139185503 0.2948200934051229 0.3988860915607601 0 0 0 0 K08972 0.0114285714285714 0.4273504273504273 K08972; putative membrane protein 82.0 179.0 0.0 1.0 1.0 S 4.0 175.0 3.0 0.988826815642458 COG1950 Uncharacterized_membrane_protein_YvlD,_DUF360_family YvlD 179.0 0.0223463687150838 0.9776536312849162 0.0259131661963064 0.774388648686523 0.4001509074414147 0.7484754824902167 0 0 0 0 K08973 0.0171428571428571 0.2592592592592592 hemJ; protoporphyrinogen IX oxidase [EC:1.3.99.-] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 102.0 89.0 0.0 1.0 1.0 S 6.0 93.0 4.0 0.898989898989899 COG1981 Protoporphyrinogen_oxidase_HemJ_(unrelated_to_HemG_or_HemY) HemJ 99.0 0.0606060606060606 0.9393939393939394 0.0016420269587962 0.0035514677987729 0.0025967473787845 0.0019094408399766 0 0 0 0 K08974 0.2057142857142857 0.2079772079772079 K08974; putative membrane protein 181.0 152.0 0.0 1.0 1.0 S 75.0 77.0 1.0 1.0 COG2035 Uncharacterized_membrane_protein,_DUF368_family 152.0 0.4934210526315789 0.506578947368421 0.226983703598525 0.642471580090944 0.4347276418447344 0.415487876492419 0 0 0 0 K08975 0.6485714285714286 0.0 K08975; putative membrane protein 221.0 260.0 252.0 2.0 0.970149253731343 S 268.0 0.0 1.0 1.0 COG2237 Uncharacterized_membrane_protein 268.0 1.0 0.0 0.930749105655439 0.0973270930951194 0.5140380993752792 0.8334220125603196 0 0 1 1 K08976 0.1228571428571428 0.1737891737891738 K08976; putative membrane protein 118.0 144.0 142.0 3.0 0.979591836734694 S 79.0 68.0 3.0 0.925170068027211 COG2322 Predicted_membrane_metallochaperone_YozB_(3H,_Sco1_fusion),_DUF420_family YozB 147.0 0.5374149659863946 0.4625850340136054 0.0018714363411629 0.0033020841805906 0.0025867602608767 0.0014306478394277 0 0 0 0 K08977 0.1542857142857142 0.0 cruF; bisanhydrobacterioruberin hydratase [EC:4.2.1.161] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 234.0 55.0 0.0 1.0 1.0 S 55.0 0.0 1.0 1.0 COG2324 Uncharacterized_membrane_protein 55.0 1.0 0.0 0.0092794639254451 0.0216419439410884 0.0154607039332667 0.0123624800156432 0 0 0 0 K08978 0.1742857142857143 0.2136752136752136 TC.BAT1; bacterial/archaeal transporter family protein 97.0 105.0 58.0 3.0 0.65625 S 73.0 87.0 2.0 0.80625 COG2510 Riboflavin_transporter_RibN,_EamA_domain RibN 160.0 0.45625 0.54375 0.576426911771886 0.973678648401646 0.7750527800867659 0.39725173662976 0 1 0 1 K08979 0.4457142857142857 0.0 K08979; putative membrane protein 215.0 163.0 0.0 1.0 1.0 S 163.0 0.0 1.0 1.0 COG3356 Predicted_membrane-associated_lipid_hydrolase,_neutral_ceramidase_superfamily 163.0 1.0 0.0 0.916102953910473 0.578029768842888 0.7470663613766806 0.338073185067585 0 0 1 1 K08980 0.0942857142857142 0.0142450142450142 K08980; putative membrane protein 157.0 46.0 0.0 1.0 1.0 S 41.0 5.0 1.0 1.0 COG3374 Uncharacterized_membrane_protein 46.0 0.8913043478260869 0.108695652173913 0.0079376580066242 0.08522921396991 0.0465834359882671 0.0772915559632858 0 0 0 0 K08981 0.1914285714285714 0.1794871794871795 K08981; putative membrane protein 90.0 153.0 0.0 1.0 1.0 S 81.0 75.0 3.0 0.967948717948718 COG3428 Uncharacterized_membrane_protein_YdbT,_contains_bPH2_(bacterial_pleckstrin_homology)_domain YdbT 156.0 0.5192307692307693 0.4807692307692308 0.0061041115647631 0.0133951268592553 0.0097496192120092 0.0072910152944922 0 0 0 0 K08982 0.2 0.1652421652421652 K08982; putative membrane protein 40.0 184.0 180.0 2.0 0.978723404255319 S 112.0 82.0 8.0 0.435897435897436 COG3462 Uncharacterized_protein,_contains_short_C-terminal_(SHOCT)_domain TM0315 194.0 0.5773195876288659 0.422680412371134 0.0512477566264727 0.55551888786059 0.3033833222435314 0.5042711312341173 0 0 0 0 K08983 0.0 0.0341880341880341 K08983; putative membrane protein 135.0 12.0 0.0 1.0 1.0 S 0.0 12.0 1.0 1.0 COG3556 Uncharacterized_membrane_protein 12.0 0.0 1.0 0.032133450562871 0.0940636738991286 0.0630985622309998 0.0619302233362576 0 0 0 0 K08984 0.0314285714285714 0.0769230769230769 yjdF; putative membrane protein 147.0 43.0 0.0 1.0 1.0 S 12.0 31.0 1.0 1.0 COG3647 Uncharacterized_membrane_protein_YjdF YjdF 43.0 0.2790697674418604 0.7209302325581395 0.0219084908177398 0.071456703719485 0.0466825972686123 0.0495482129017452 0 0 0 0 K08985 0.0 0.0113960113960113 K08985; putative lipoprotein 95.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG3650 Uncharacterized_membrane_protein 4.0 0.0 1.0 0.0776114918881084 0.167213524741094 0.1224125083146012 0.0896020328529856 0 0 0 0 K08986 0.0 0.0427350427350427 ycgQ; putative membrane protein 147.0 16.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG3689 Uncharacterized_membrane_protein_YcgQ,__UPF0703/DUF1980_family YcgQ 18.0 0.0 1.0 0.0090744319827266 0.0847858978628345 0.0469301649227805 0.0757114658801079 0 0 0 0 K08987 0.0 0.0883190883190883 K08987; putative membrane protein 107.0 32.0 31.0 2.0 0.96969696969697 S 0.0 33.0 1.0 1.0 COG3759 Uncharacterized_membrane_protein 33.0 0.0 1.0 0.021219443102027 0.246001961212722 0.1336107021573745 0.224782518110695 0 0 0 0 K08988 0.0 0.0797720797720797 K08988; putative membrane protein 121.0 29.0 0.0 1.0 1.0 S 0.0 29.0 1.0 1.0 COG3762 Uncharacterized_membrane_protein 29.0 0.0 1.0 0.00776001667267 0.0190806651818535 0.0134203409272617 0.0113206485091835 0 0 0 0 K08989 0.0 0.0626780626780626 K08989; putative membrane protein 118.0 23.0 21.0 2.0 0.92 S 0.0 25.0 2.0 0.96 COG3766 Uncharacterized_membrane_protein_YjfL,_UPF0719_family YjfL 25.0 0.0 1.0 0.0071423721482255 0.0201668823005777 0.0136546272244015 0.0130245101523522 0 0 0 0 K08990 0.0 0.0769230769230769 ycjF; putative membrane protein 242.0 27.0 0.0 1.0 1.0 S 0.0 27.0 1.0 1.0 COG3768 Uncharacterized_membrane_protein_YcjF,_UPF0283_family YcjF 27.0 0.0 1.0 0.0007278520134402 0.0024770225203935 0.0016024372669168 0.0017491705069533 0 0 0 0 K08992 0.0 0.1054131054131054 lapA; lipopolysaccharide assembly protein A 62.0 22.0 7.0 2.0 0.594594594594595 S 0.0 38.0 4.0 0.789473684210526 COG5416 Uncharacterized_integral_membrane_protein_YrvD YrvD 38.0 0.0 1.0 0.0623370766868466 0.0167637946601293 0.0395504356734879 0.0455732820267173 0 0 0 0 K08993 0.0 0.0142450142450142 yhhL; putative membrane protein 88.0 4.0 0.0 1.0 1.0 S 0.0 5.0 2.0 0.8 COG3776 Uncharacterized_conserved_protein_YhhL,_DUF1145_family YhhL 5.0 0.0 1.0 0.0043378120900407 0.0089167273974151 0.0066272697437279 0.0045789153073744 0 0 0 0 K08994 0.0 0.1225071225071225 yneE, BEST; ion channel-forming bestrophin family protein 166.0 84.0 0.0 1.0 1.0 S 0.0 84.0 1.0 1.0 COG3781 Predicted_membrane_chloride_channel,_bestrophin_family YneE 84.0 0.0 1.0 0.0034528988365934 0.0077755486368083 0.0056142237367008 0.0043226498002149 0 0 0 0 K08995 0.0 0.0826210826210826 K08995; putative membrane protein 96.0 50.0 0.0 1.0 1.0 S 0.0 50.0 1.0 1.0 COG3652 Predicted_outer_membrane_protein,_contains_DUF4142_domain 50.0 0.0 1.0 0.0029366541067539 0.0072636361807122 0.005100145143733 0.0043269820739583 0 0 0 0 K08996 0.0 0.0227920227920227 yagU; putative membrane protein 147.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG3477 Uncharacterized_membrane_protein_YagU,_involved_in_acid_resistance,_DUF1440_family YagU 8.0 0.0 1.0 0.04069025778704 0.0905517942132097 0.0656210260001248 0.0498615364261697 0 0 0 0 K08997 0.0 0.074074074074074 SELENOO, selO; serine/tyrosine/threonine adenylyltransferase [EC:2.7.7.-] 419.0 26.0 0.0 1.0 1.0 S 0.0 26.0 1.0 1.0 COG0397 Protein_adenylyltransferase_(AMPylase)_SelO/YdiU_(selenoprotein_O) SelO 26.0 0.0 1.0 0.0103572792281939 0.0255895748290351 0.0179734270286145 0.0152322956008412 0 0 0 0 K08998 0.0 0.7264957264957265 K08998; uncharacterized protein 30.0 234.0 201.0 3.0 0.821052631578947 S 0.0 285.0 2.0 0.880701754385965 COG0759 Membrane-anchored_protein_YidD,_putatitve_component_of_membrane_protein_insertase_Oxa1/YidC/SpoIIIJ YidD 285.0 0.0 1.0 0.1942696656916 0.614774918010464 0.404522291851032 0.420505252318864 0 0 0 0 K08999 0.3228571428571428 0.5042735042735043 K08999; uncharacterized protein 48.0 274.0 246.0 5.0 0.837920489296636 S 121.0 204.0 4.0 0.902140672782875 COG1259 Bifunctional_DNase/RNase 325.0 0.3723076923076923 0.6276923076923077 0.0593247066150148 0.0417051995929586 0.0505149531039866 0.0176195070220562 0 0 0 0 K09000 0.1028571428571428 0.1253561253561253 cmr4; CRISPR-associated protein Cmr4 122.0 65.0 30.0 4.0 0.631067961165049 L 43.0 60.0 3.0 0.970873786407767 COG1336 CRISPR-Cas_system_type_III_CMR-effector_complex_subunit_Cmr4,_RAMP_superfamily_Cas7_group Cmr4 103.0 0.4174757281553398 0.5825242718446602 0.102517110905099 0.928864693648064 0.5156909022765815 0.826347582742965 0 0 0 0 K09001 0.0171428571428571 0.376068376068376 anmK; anhydro-N-acetylmuramic acid kinase [EC:2.7.1.170] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 227.0 86.0 41.0 3.0 0.614285714285714 O 6.0 134.0 1.0 1.0 COG2377 1,6-Anhydro-N-acetylmuramate_kinase AnmK 140.0 0.0428571428571428 0.9571428571428572 0.603800160715175 0.706023455732593 0.654911808223884 0.102223295017418 0 1 0 1 K09002 0.0771428571428571 0.0883190883190883 csm3; CRISPR-associated protein Csm3 118.0 47.0 31.0 2.0 0.746031746031746 L 30.0 33.0 1.0 1.0 COG1337 CRISPR-Cas_system_type_III_CSM-effector_complex_subunit_Csm3,_RAMP_superfamily_Cas7_group Csm3 63.0 0.4761904761904761 0.5238095238095238 0.841135921746016 0.810863646344676 0.825999784045346 0.03027227540134 1 1 1 1 K09003 0.3771428571428571 0.0769230769230769 K09003; uncharacterized protein 275.0 170.0 0.0 1.0 1.0 S 143.0 27.0 1.0 1.0 COG1415 Uncharacterized_conserved_protein,_DUF763_domain 170.0 0.8411764705882353 0.1588235294117647 0.530628117078574 0.787852464604473 0.6592402908415236 0.2572243475258989 0 1 0 1 K09004 0.1342857142857142 0.1196581196581196 K09004; uncharacterized protein 62.0 96.0 95.0 3.0 0.979591836734694 S 53.0 56.0 2.0 0.990825688073395 COG1416 Intracellular_sulfur_oxidation_protein,_DsrE/DsrF_family 109.0 0.4862385321100917 0.5137614678899083 0.0224500802968121 0.0138528560960885 0.0181514681964503 0.0085972242007236 0 0 0 0 K09005 0.4514285714285714 0.3874643874643874 K09005; uncharacterized protein 10.0 386.0 383.0 2.0 0.992287917737789 S 239.0 150.0 3.0 0.984575835475578 COG1430 Uncharacterized_conserved_membrane_protein,_UPF0127_family 389.0 0.6143958868894601 0.3856041131105398 0.0863932031505335 0.220981054902048 0.1536871290262907 0.1345878517515145 0 0 0 0 K09006 0.2028571428571428 0.0341880341880341 K09006; RNA-free ribonuclease P [EC:3.1.26.5] 178.0 71.0 59.0 2.0 0.855421686746988 V 71.0 12.0 1.0 1.0 COG1458 Predicted_RNase_MK1237,_contains_PIN_domain,_UPF0278_family 83.0 0.8554216867469879 0.144578313253012 0.923473514130063 0.694925883287048 0.8091996987085555 0.228547630843015 1 1 1 1 K09007 0.0142857142857142 0.2222222222222222 folE2; GTP cyclohydrolase IB [EC:3.5.4.16] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 185.0 70.0 56.0 3.0 0.804597701149425 S 5.0 82.0 2.0 0.96551724137931 COG1469 GTP_cyclohydrolase_FolE2 FolE2 87.0 0.057471264367816 0.942528735632184 0.425971309645908 0.28456609748804 0.355268703566974 0.141405212157868 0 0 0 0 K09009 0.0 0.1082621082621082 K09009; uncharacterized protein 130.0 37.0 36.0 2.0 0.973684210526316 S 0.0 38.0 1.0 1.0 COG1507 Uncharacterized_conserved_protein,_DUF501_family 38.0 0.0 1.0 0.437628961781251 0.386234579353602 0.4119317705674264 0.0513943824276489 0 0 0 0 K09010 0.0114285714285714 0.017094017094017 K09010; uncharacterized protein 566.0 10.0 0.0 1.0 1.0 S 4.0 6.0 1.0 1.0 COG1542 Uncharacterized_conserved_protein,_DUF505_domain 10.0 0.4 0.6 0.127542677830298 0.093124286298369 0.1103334820643335 0.0344183915319289 0 0 0 0 K09011 0.3085714285714285 0.0484330484330484 cimA; (R)-citramalate synthase [EC:2.3.3.21] path:map00290,path:map00660,path:map01100,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,C5-Branched dibasic acid metabolism,Metabolic pathways,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 455.0 126.0 124.0 2.0 0.984375 E 111.0 17.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 128.0 0.8671875 0.1328125 0.0022609897655546 0.843117863473495 0.4226894266195248 0.8408568737079405 0 0 0 0 K09012 0.0 0.0341880341880341 sufR; DeoR family transcriptional regulator, suf operon transcriptional repressor 209.0 13.0 0.0 1.0 1.0 K 0.0 13.0 1.0 1.0 COG2345 Predicted_transcriptional_regulator,_ArsR_family 13.0 0.0 1.0 4.29994805040427e-13 0.0004030112216352 0.0002015056110325 0.0004030112212052 0 0 0 0 K09013 0.7085714285714285 0.7264957264957265 sufC; Fe-S cluster assembly ATP-binding protein 191.0 420.0 317.0 3.0 0.793950850661626 O 266.0 263.0 1.0 1.0 COG0396 Fe-S_cluster_assembly_ATPase_SufC SufC 529.0 0.502835538752363 0.497164461247637 0.0015658505271358 0.368096047042384 0.1848309487847599 0.3665301965152482 0 0 0 0 K09014 0.5057142857142857 0.6296296296296297 sufB; Fe-S cluster assembly protein SufB 336.0 460.0 0.0 1.0 1.0 O 231.0 229.0 1.0 1.0 COG0719 Fe-S_cluster_assembly_scaffold_protein_SufB SufB 460.0 0.5021739130434782 0.4978260869565217 0.499077005988364 0.498542292718214 0.498809649353289 0.00053471327015 0 0 0 0 K09015 0.3171428571428571 0.584045584045584 sufD; Fe-S cluster assembly protein SufD 142.0 318.0 0.0 1.0 1.0 O 111.0 207.0 1.0 1.0 COG0719 Fe-S_cluster_assembly_scaffold_protein_SufB SufB 318.0 0.3490566037735849 0.6509433962264151 0.0035798451673899 0.108052623017708 0.0558162340925489 0.1044727778503181 0 0 0 0 K09016 0.0 0.0113960113960113 rutG; putative pyrimidine permease RutG 408.0 5.0 0.0 1.0 1.0 F 0.0 5.0 1.0 1.0 COG2233 Xanthine/uracil_permease UraA 5.0 0.0 1.0 0.0556590278183561 0.0973802465482897 0.0765196371833229 0.0417212187299336 0 0 0 0 K09017 0.0 0.2051282051282051 rutR; TetR/AcrR family transcriptional regulator 54.0 103.0 0.0 1.0 1.0 K 0.0 103.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 103.0 0.0 1.0 0.148937550493435 0.0920339172539205 0.1204857338736777 0.0569036332395144 0 0 0 0 K09018 0.0 0.017094017094017 rutA; pyrimidine oxygenase [EC:1.14.99.46] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 344.0 5.0 4.0 2.0 0.833333333333333 C 0.0 6.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 6.0 0.0 1.0 0.157411505681658 0.250484942124961 0.2039482239033094 0.0930734364433029 0 0 0 0 K09019 0.0028571428571428 0.0826210826210826 rutE; 3-hydroxypropanoate dehydrogenase [EC:1.1.1.-] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 182.0 31.0 0.0 1.0 1.0 C 1.0 30.0 1.0 1.0 COG0778 Nitroreductase NfnB 31.0 0.032258064516129 0.967741935483871 0.021904513709739 0.0436562550958738 0.0327803844028064 0.0217517413861348 0 0 0 0 K09020 0.0228571428571428 0.0854700854700854 rutB; ureidoacrylate peracid hydrolase [EC:3.5.1.110] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 123.0 47.0 0.0 1.0 1.0 Q 11.0 36.0 2.0 0.978723404255319 COG1335 Nicotinamidase-related_amidase PncA 47.0 0.2340425531914893 0.7659574468085106 0.0026776180875593 0.469924227764257 0.2363009229259081 0.4672466096766977 0 0 0 0 K09021 0.0 0.0313390313390313 rutC; aminoacrylate peracid reductase path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 121.0 11.0 0.0 1.0 1.0 J 0.0 11.0 1.0 1.0 COG0251 Enamine_deaminase_RidA,_house_cleaning_of_reactive_enamine_intermediates,_YjgF/YER057c/UK114_family RidA 11.0 0.0 1.0 0.226083926474039 0.181423331133126 0.2037536288035825 0.0446605953409129 0 0 0 0 K09022 0.3457142857142857 0.5498575498575499 ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] 68.0 377.0 376.0 3.0 0.994722955145119 J 144.0 235.0 1.0 1.0 COG0251 Enamine_deaminase_RidA,_house_cleaning_of_reactive_enamine_intermediates,_YjgF/YER057c/UK114_family RidA 379.0 0.3799472295514511 0.6200527704485488 0.846793719820017 0.957504526530618 0.9021491231753176 0.1107108067106009 1 1 1 1 K09023 0.0028571428571428 0.0085470085470085 rutD; aminoacrylate hydrolase [EC:3.5.1.-] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 234.0 1.0 0.0 4.0 0.25 F 1.0 3.0 3.0 0.5 COG2021 Homoserine_O-acetyltransferase MET2 4.0 0.25 0.75 0.218688301187956 0.323762612776848 0.2712254569824019 0.1050743115888919 0 0 0 0 K09024 0.0 0.0427350427350427 rutF; flavin reductase [EC:1.5.1.-] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 145.0 13.0 11.0 3.0 0.8125 S 0.0 16.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 16.0 0.0 1.0 0.0338008076435357 0.0510016975847199 0.0424012526141278 0.0172008899411842 0 0 0 0 K09065 0.0771428571428571 0.1851851851851851 argF; N-acetylornithine carbamoyltransferase [EC:2.1.3.9] path:map00220,path:map01100,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of amino acids 228.0 96.0 94.0 2.0 0.979591836734694 E 31.0 67.0 1.0 1.0 COG0078 Ornithine_carbamoyltransferase ArgF 98.0 0.3163265306122449 0.6836734693877551 0.626086054169041 0.984227622820487 0.805156838494764 0.3581415686514461 0 1 0 1 K09116 0.3542857142857142 0.1168091168091168 K09116; damage-control phosphatase, subfamily I [EC:3.1.3.-] 121.0 189.0 186.0 2.0 0.984375 S 147.0 45.0 2.0 0.989583333333333 COG1578 House-cleaning_carbohydrate_phosphatase,_DUF89_family DUF89 192.0 0.765625 0.234375 0.855951906259431 0.964684509914446 0.9103182080869384 0.108732603655015 1 1 1 1 K09117 0.0028571428571428 0.6894586894586895 K09117; uncharacterized protein 121.0 244.0 239.0 2.0 0.979919678714859 S 1.0 249.0 2.0 0.996 COG1610 Uncharacterized_conserved_protein_YqeY,_may_have_tRNA_amino_acid_amidase_activity YqeY 250.0 0.004 0.996 0.179966582831363 0.287397387539873 0.233681985185618 0.1074308047085099 0 0 0 0 K09118 0.1428571428571428 0.2336182336182336 K09118; uncharacterized protein 448.0 139.0 132.0 3.0 0.920529801324503 S 52.0 99.0 2.0 0.940397350993378 COG1615 Uncharacterized_membrane_protein,_UPF0182_family 151.0 0.3443708609271523 0.6556291390728477 0.559622229771052 0.943372521119041 0.7514973754450465 0.383750291347989 0 1 0 1 K09119 0.44 0.0 cgi121; KEOPS complex subunit Cgi121 89.0 133.0 109.0 2.0 0.847133757961784 S 157.0 0.0 1.0 1.0 COG1617 tRNA_threonylcarbamoyladenosine_modification_(KEOPS)_complex,__Cgi121_subunit Cgi121 157.0 1.0 0.0 0.145168077828489 0.452389895772971 0.29877898680073 0.307221817944482 0 0 0 0 K09120 0.6314285714285715 0.0142450142450142 K09120; uncharacterized protein 84.0 206.0 176.0 2.0 0.872881355932203 L 231.0 5.0 1.0 1.0 COG1628 Endonuclease_V_homolog,_UPF0215_family 236.0 0.9788135593220338 0.0211864406779661 0.943705271513496 0.97216560168664 0.957935436600068 0.0284603301731439 1 1 1 1 K09121 0.3857142857142857 0.3219373219373219 larC; pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase [EC:4.99.1.12] 191.0 260.0 243.0 4.0 0.884353741496599 S 163.0 131.0 4.0 0.935374149659864 COG1641 CTP-dependent_cyclometallase,_nickel-pincer_nucleotide_(NPN)_cofactor_biosynthesis LarC 294.0 0.5544217687074829 0.445578231292517 0.801858104425484 0.907165985561355 0.8545120449934195 0.1053078811358709 1 1 1 1 K09122 0.4885714285714285 0.1424501424501424 K09122; uncharacterized protein 68.0 183.0 165.0 5.0 0.820627802690583 S 172.0 51.0 4.0 0.982062780269058 COG1656 Uncharacterized_conserved_protein,_contains_PIN-related_Mut7-C_RNAse_domain Mut7-C 223.0 0.7713004484304933 0.2286995515695067 0.434988065293492 0.627687267792309 0.5313376665429005 0.192699202498817 0 0 0 0 K09123 0.5371428571428571 0.0427350427350427 lhpI; cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171] path:map00330 Arginine and proline metabolism 237.0 217.0 216.0 2.0 0.995412844036697 S 197.0 21.0 2.0 0.995412844036697 COG1679 Mevalonate_5-phosphate_dehydratase_subunit_1,_aconitase_superfamily_(modified_mevalonate_pathway) AcnX1 218.0 0.9036697247706422 0.0963302752293578 0.83550889041703 0.975918411534881 0.9057136509759556 0.140409521117851 1 1 1 1 K09124 0.0142857142857142 0.0227920227920227 K09124; uncharacterized protein 322.0 14.0 0.0 1.0 1.0 S 6.0 10.0 1.0 1.0 COG1700 Predicted_anti-virus_defense_system_component_AQ645,_contains_DUF2357_and__PD-(D/E)xK_nuclease_domains AQ645 16.0 0.375 0.625 0.0592023584341002 0.140948744216596 0.1000755513253481 0.0817463857824958 0 0 0 0 K09125 0.2457142857142857 0.3675213675213675 yhhQ; queuosine precursor transporter 118.0 124.0 9.0 2.0 0.518828451882845 U 101.0 138.0 1.0 1.0 COG1738 Queuosine_precursor_transporter_YhhQ,_DUF165_family YhhQ 239.0 0.4225941422594142 0.5774058577405857 0.0815770091928055 0.869711262217843 0.4756441357053242 0.7881342530250375 0 0 0 0 K09126 0.2114285714285714 0.0541310541310541 K09126; uncharacterized protein 148.0 106.0 0.0 1.0 1.0 S 86.0 20.0 1.0 1.0 COG1751 Ligand-binding_C-terminal_domain_of_pyruvate_kinase,_DUF1867 PK 106.0 0.8113207547169812 0.1886792452830188 0.883346064943714 0.899711595060197 0.8915288300019555 0.016365530116483 1 1 1 1 K09127 0.0685714285714285 0.0911680911680911 cmr3; CRISPR-associated protein Cmr3 74.0 48.0 41.0 2.0 0.872727272727273 L 30.0 46.0 5.0 0.605263157894737 COG1769 CRISPR-Cas_system_type_III_CMR-effector_complex_subunit_Cmr3,_RAMP_superfamily_Cas5_group Cmr3 76.0 0.3947368421052631 0.6052631578947368 0.10961073678224 0.93307150035791 0.521341118570075 0.82346076357567 0 0 0 0 K09128 0.4828571428571429 0.0313390313390313 acnX2; mevalonate 5-phosphate dehydratase small subunit [EC:4.2.1.-] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 95.0 169.0 145.0 3.0 0.871134020618557 C 178.0 16.0 3.0 0.938144329896907 COG1786 Mevalonate_5-phosphate_dehydratase_subunit_2,_swiveling_domain_(modified_mevalonate_pathway) AcnX2 194.0 0.9175257731958762 0.0824742268041237 0.929246813872281 0.700798956230545 0.815022885051413 0.228447857641736 1 1 1 1 K09129 0.3028571428571429 0.1196581196581196 K09129; uncharacterized protein 144.0 77.0 4.0 2.0 0.513333333333333 L 108.0 42.0 1.0 1.0 COG1839 Adenosine/AMP_kinase 150.0 0.72 0.28 0.952379087867671 0.968747174269548 0.9605631310686096 0.016368086401877 1 1 1 1 K09130 0.0142857142857142 0.0056980056980056 K09130; uncharacterized protein 220.0 7.0 0.0 1.0 1.0 S 5.0 2.0 1.0 1.0 COG1851 Uncharacterized_conserved_protein,_UPF0128_family 7.0 0.7142857142857143 0.2857142857142857 0.502345731334166 0.705756405839888 0.6040510685870271 0.2034106745057219 0 0 0 1 K09131 0.4542857142857143 0.4301994301994302 K09131; uncharacterized protein 53.0 276.0 239.0 3.0 0.878980891719745 S 161.0 153.0 4.0 0.977707006369427 COG1872 Uncharacterized_conserved_protein_YggU,_UPF0235/DUF167_family YggU 314.0 0.5127388535031847 0.4872611464968153 0.240366678443641 0.488881942000423 0.364624310222032 0.248515263556782 0 0 0 0 K09132 0.0971428571428571 0.0284900284900284 K09132; uncharacterized protein 95.0 43.0 35.0 2.0 0.843137254901961 S 39.0 10.0 2.0 0.92156862745098 COG1895 HEPN_domain_protein,_predicted_toxin_of_MNT-HEPN_system HEPN 49.0 0.7959183673469388 0.2040816326530612 0.200238106339717 0.0669548858046728 0.1335964960721949 0.1332832205350442 0 0 0 0 K09133 0.12 0.0626780626780626 K09133; uncharacterized protein 286.0 58.0 49.0 2.0 0.865671641791045 S 45.0 22.0 1.0 1.0 COG1906 Predicted_GntP-related_membrane_permease_AF0261,_DUF401_family 67.0 0.6716417910447762 0.3283582089552239 0.990690151035064 0.980999317134611 0.9858447340848376 0.009690833900453 1 1 1 1 K09134 0.0028571428571428 0.0028490028490028 flA; adenosyl-fluoride synthase [EC:2.5.1.63] 260.0 2.0 0.0 1.0 1.0 S 1.0 1.0 1.0 1.0 COG1912 Stereoselective_(R,S)-S-adenosylmethionine_hydrolase_(adenosine-forming) 2.0 0.5 0.5 0 0 0 0 K09135 0.1285714285714285 0.0 K09135; uncharacterized protein 103.0 45.0 0.0 1.0 1.0 S 45.0 0.0 1.0 1.0 COG1935 Uncharacterized_conserved_protein,_DUF473_domain 45.0 1.0 0.0 0.0020907059384419 0.0106818950644363 0.0063863005014391 0.0085911891259944 0 0 0 0 K09136 0.3028571428571429 0.2336182336182336 ycaO; ribosomal protein S12 methylthiotransferase accessory factor 100.0 140.0 88.0 4.0 0.633484162895928 S 113.0 108.0 5.0 0.819004524886878 COG1944 Ribosomal_protein_S12_methylthiotransferase_accessory_factor_YcaO YcaO 221.0 0.5113122171945701 0.4886877828054298 0.0126754428406606 0.0690820527338481 0.0408787477872543 0.0564066098931875 0 0 0 0 K09137 0.1285714285714285 0.1851851851851851 K09137; uncharacterized protein 71.0 69.0 12.0 2.0 0.547619047619048 S 48.0 78.0 3.0 0.904761904761905 COG1993 PII-like_signaling_protein 126.0 0.3809523809523809 0.6190476190476191 0.0737805290448676 0.0862137085403822 0.0799971187926248 0.0124331794955146 0 0 0 0 K09138 0.1628571428571428 0.0797720797720797 K09138; uncharacterized protein 111.0 91.0 80.0 2.0 0.892156862745098 S 69.0 33.0 1.0 1.0 COG2014 Uncharacterized_conserved_protein,_contains_DUF4213_and_DUF364_domains 102.0 0.6764705882352942 0.3235294117647059 0.895360923818367 0.907595398907031 0.901478161362699 0.012234475088664 1 1 1 1 K09139 0.1114285714285714 0.0142450142450142 K09139; uncharacterized protein 163.0 44.0 0.0 1.0 1.0 S 39.0 5.0 1.0 1.0 COG2029 Uncharacterized_conserved_protein,_DUF366_domain 44.0 0.8863636363636364 0.1136363636363636 0.0116334945865205 0.106919242492616 0.0592763685395682 0.0952857479060955 0 0 0 0 K09140 0.5371428571428571 0.0085470085470085 TSR3; pre-rRNA-processing protein TSR3 133.0 98.0 4.0 3.0 0.502564102564103 J 192.0 3.0 2.0 0.98974358974359 COG2042 Ribosome_biogenesis_protein_Tsr3_(rRNA_maturation) Tsr3 195.0 0.9846153846153848 0.0153846153846153 0.688749261263258 0.746625510760905 0.7176873860120815 0.057876249497647 0 0 0 1 K09141 0.7057142857142857 0.2706552706552707 K09141; uncharacterized protein 64.0 374.0 373.0 2.0 0.997333333333333 S 270.0 100.0 2.0 0.954666666666667 COG2078 Predicted_RNA_modification_protein,_AMMECR1_domain AMMECR1 370.0 0.7297297297297297 0.2702702702702703 0.35198872513403 0.716316421913861 0.5341525735239455 0.364327696779831 0 0 0 0 K09142 0.4485714285714285 0.0 SPOUT1; methyltransferase [EC:2.1.1.-] 176.0 160.0 0.0 1.0 1.0 S 160.0 0.0 1.0 1.0 COG2106 Predicted_RNA_methylase_MTH1,_SPOUT_superfamily MTH1 160.0 1.0 0.0 0.134606877068211 0.258268860274742 0.1964378686714765 0.1236619832065309 0 0 0 0 K09143 0.2257142857142857 0.0512820512820512 K09143; uncharacterized protein 76.0 109.0 0.0 1.0 1.0 S 96.0 18.0 1.0 1.0 COG2164 Uncharacterized_protein_with_cyclophilin_fold,_contains_DUF369_domain 114.0 0.8421052631578947 0.1578947368421052 0.932525803693766 0.965314422169974 0.94892011293187 0.0327886184762079 1 1 1 1 K09144 0.1542857142857142 0.094017094017094 K09144; uncharacterized protein 61.0 96.0 67.0 3.0 0.695652173913043 S 93.0 42.0 1.0 1.0 COG2253 Predicted_nucleotidyltransferase_component_of_viral_defense_system 135.0 0.6888888888888889 0.3111111111111111 0.361460772261015 0.428302437434628 0.3948816048478215 0.066841665173613 0 0 0 0 K09145 0.0228571428571428 0.0284900284900284 K09145; uncharacterized protein 118.0 19.0 0.0 1.0 1.0 S 8.0 11.0 1.0 1.0 COG2306 Predicted_RNA-binding_protein,_associated_with_RNAse_of_E/G_family,_DUF402_domain 19.0 0.4210526315789473 0.5789473684210527 0.0158433020283536 0.0215137024725982 0.0186785022504759 0.0056704004442445 0 0 0 0 K09146 0.0 0.0199430199430199 K09146; uncharacterized protein 141.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 COG2306 Predicted_RNA-binding_protein,_associated_with_RNAse_of_E/G_family,_DUF402_domain 9.0 0.0 1.0 0.0027621925849443 0.01529033246624 0.0090262625255921 0.0125281398812957 0 0 0 0 K09147 0.2314285714285714 0.0256410256410256 K09147; uncharacterized protein 102.0 91.0 0.0 1.0 1.0 S 82.0 9.0 1.0 1.0 COG2410 Predicted_nuclease_(RNAse_H_fold) 91.0 0.9010989010989012 0.0989010989010989 0.931723495737751 0.960581588636002 0.9461525421868764 0.0288580928982509 1 1 1 1 K09148 0.72 0.0 K09148; uncharacterized protein 62.0 253.0 0.0 1.0 1.0 S 253.0 0.0 1.0 1.0 COG2412 Uncharacterized_conserved_protein,_DUF424_domain 253.0 1.0 0.0 0.776638417457795 0.531520792011143 0.654079604734469 0.245117625446652 0 0 1 1 K09149 0.1485714285714285 0.0 K09149; uncharacterized protein 111.0 59.0 0.0 1.0 1.0 S 59.0 0.0 1.0 1.0 COG2430 Uncharacterized_conserved_protein,_DUF432_domain 59.0 1.0 0.0 0.486388251868874 0.69028137675695 0.588334814312912 0.2038931248880759 0 0 0 0 K09150 0.5257142857142857 0.0 K09150; uncharacterized protein 191.0 179.0 172.0 2.0 0.96236559139785 S 185.0 0.0 1.0 1.0 COG2433 Possible_nuclease_of_RNase_H_fold,_RuvC/YqgF_family 185.0 1.0 0.0 0.0099829108505387 0.743676483057281 0.3768296969539098 0.7336935722067423 0 0 0 0 K09152 0.4885714285714285 0.0 K09152; uncharacterized protein 72.0 163.0 153.0 2.0 0.942196531791907 D 173.0 0.0 1.0 1.0 COG2450 Predicted_archaeal_cell_division_protein,_SepF_family SepFarc 173.0 1.0 0.0 0.96786655132375 0.895723750574907 0.9317951509493284 0.0721428007488429 0 0 1 1 K09153 0.0885714285714285 0.1595441595441595 K09153; small membrane protein 70.0 80.0 68.0 2.0 0.869565217391304 S 31.0 61.0 7.0 0.695652173913044 COG2456 Uncharacterized_conserved_protein,_DUF2304_domain 92.0 0.3369565217391304 0.6630434782608695 0.0287817441011304 0.163150632389711 0.0959661882454207 0.1343688882885806 0 0 0 0 K09154 0.36 0.0284900284900284 K09154; uncharacterized protein 105.0 137.0 0.0 1.0 1.0 S 127.0 10.0 1.0 1.0 COG2457 Uncharacterized_conserved_protein,_DUF447_domain 137.0 0.927007299270073 0.072992700729927 0.0104880246356107 0.744246525125745 0.3773672748806778 0.7337585004901342 0 0 0 0 K09155 0.1171428571428571 0.1082621082621082 K09155; uncharacterized protein 125.0 69.0 41.0 3.0 0.676470588235294 S 50.0 43.0 1.0 1.0 COG2461 Uncharacterized_conserved_protein_AF0170,_contains_SAB,_hemerythrin_HHE,_and_PAS_domains 93.0 0.5376344086021505 0.4623655913978494 0.975680218256152 0.947014025774099 0.9613471220151256 0.028666192482053 1 1 1 1 K09156 0.1714285714285714 0.0 cheF; taxis protein CheF 180.0 103.0 94.0 2.0 0.919642857142857 K 112.0 0.0 1.0 1.0 COG2469 Archaeal_chemotaxis_protein_CheF CheF 112.0 1.0 0.0 0.388185553815339 0.0895379074663597 0.2388617306408493 0.2986476463489793 0 0 0 0 K09157 0.2314285714285714 0.1566951566951566 K09157; uncharacterized protein 309.0 149.0 0.0 1.0 1.0 S 90.0 59.0 1.0 1.0 COG2848 Uncharacterized_conserved_protein,_UPF0210_family 149.0 0.6040268456375839 0.3959731543624161 0.687710638563123 0.977592979629733 0.832651809096428 0.28988234106661 0 1 0 1 K09158 0.0 0.1481481481481481 K09158; uncharacterized protein 47.0 52.0 0.0 1.0 1.0 S 0.0 52.0 1.0 1.0 COG2921 Putative_lipoate-binding_regulatory_protein,_UPF0250_family YbeD 52.0 0.0 1.0 0.0036727111310962 0.0072577186569524 0.0054652148940243 0.0035850075258562 0 0 0 0 K09159 0.0 0.1623931623931624 cptB; antitoxin CptB 51.0 50.0 43.0 2.0 0.87719298245614 S 0.0 57.0 1.0 1.0 COG2938 Succinate_dehydrogenase_flavin-adding_protein,_antitoxin_component_of_the_CptAB_toxin-antitoxin_module SdhE 57.0 0.0 1.0 0.0023382955926831 0.0058412102360027 0.0040897529143429 0.0035029146433196 0 0 0 0 K09160 0.0142857142857142 0.1282051282051282 K09160; uncharacterized protein 130.0 50.0 0.0 1.0 1.0 S 5.0 45.0 1.0 1.0 COG2983 Uncharacterized_cysteine_cluster_protein_YcgN,_CxxCxxCC_family YcgN 50.0 0.1 0.9 0.0056466906631609 0.010923839736097 0.0082852651996289 0.0052771490729361 0 0 0 0 K09161 0.0 0.0085470085470085 K09161; uncharacterized protein 164.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3013 Uncharacterized_conserved_protein_YfbU,_UPF0304_family YfbU 3.0 0.0 1.0 0 0 0 0 K09162 0.0 0.0113960113960113 cld; chlorite dismutase [EC:1.13.11.49] 214.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG3253 Coproheme_decarboxylase/chlorite_dismutase HemQ 4.0 0.0 1.0 0.0760242679080464 0.171122087078908 0.1235731774934772 0.0950978191708616 0 0 0 0 K09163 0.2657142857142857 0.1082621082621082 K09163; uncharacterized protein 185.0 146.0 0.0 1.0 1.0 S 105.0 41.0 2.0 0.952054794520548 COG3294 Metal-dependent_phosphatase/phosphodiesterase,_HD_supefamily 146.0 0.7191780821917808 0.2808219178082192 0.671013967048775 0.952592022925738 0.8118029949872565 0.2815780558769629 0 1 0 1 K09164 0.12 0.1196581196581196 K09164; uncharacterized protein 114.0 105.0 101.0 3.0 0.954545454545455 S 59.0 51.0 1.0 1.0 COG3358 Uncharacterized_conserved_protein,_DUF1684_family 110.0 0.5363636363636364 0.4636363636363636 0.0134659675033237 0.850196019775816 0.4318309936395699 0.8367300522724923 0 0 0 0 K09165 0.1971428571428571 0.1908831908831909 K09165; dodecin 63.0 146.0 131.0 2.0 0.906832298136646 S 87.0 74.0 1.0 1.0 COG3360 Flavin-binding_protein_dodecin 161.0 0.5403726708074534 0.4596273291925465 0.103947098948133 0.554703334467881 0.329325216708007 0.4507562355197479 0 0 0 0 K09166 0.1257142857142857 0.0854700854700854 K09166; uncharacterized protein 141.0 88.0 0.0 1.0 1.0 S 58.0 30.0 1.0 1.0 COG3361 Uncharacterized_conserved_protein_YqjF,_DUF2071_family YqjF 88.0 0.6590909090909091 0.3409090909090909 0.0031834955594278 0.0094408165489496 0.0063121560541887 0.0062573209895218 0 0 0 0 K09167 0.2228571428571428 0.1339031339031339 K09167; uncharacterized protein 82.0 145.0 0.0 1.0 1.0 S 91.0 55.0 3.0 0.780821917808219 COG3402 Uncharacterized_membrane_protein_YdbS,_contains_bPH2_(bacterial_pleckstrin_homology)_domain YdbS 146.0 0.6232876712328768 0.3767123287671233 0.0157485630244053 0.383925087272228 0.1998368251483166 0.3681765242478227 0 0 0 0 K09181 0.0742857142857142 0.225071225071225 yfiQ; acetyltransferase 492.0 117.0 93.0 7.0 0.75 C 33.0 117.0 5.0 0.673076923076923 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 150.0 0.22 0.78 0.0060944371410992 0.0013379317520604 0.0037161844465798 0.0047565053890388 0 0 0 0 K09187 0.0028571428571428 0.0 MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354] path:map00310,path:map01100,path:map04934 Lysine degradation,Metabolic pathways,Cushing syndrome 148.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 1.0 1.0 0.0 0 0 0 0 K09188 0.0028571428571428 0.0 MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 148.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 1.0 1.0 0.0 0 0 0 0 K09190 0.0742857142857142 0.037037037037037 K09190; uncharacterized protein 223.0 38.0 36.0 2.0 0.95 S 27.0 13.0 2.0 0.925 COG3403 Uncharacterized_conserved_protein_YcgG,_contains_conserved_FPC_and_CPF_motifs YcgG 40.0 0.675 0.325 0.0110668667751413 0.0483604578264087 0.029713662300775 0.0372935910512674 0 0 0 0 K09251 0.0028571428571428 0.0769230769230769 patA; putrescine aminotransferase [EC:2.6.1.82] path:map00310,path:map00330,path:map01100,path:map01120 Lysine degradation,Arginine and proline metabolism,Metabolic pathways,Microbial metabolism in diverse environments 357.0 24.0 17.0 2.0 0.774193548387097 E 1.0 30.0 1.0 1.0 COG4992 Acetylornithine/succinyldiaminopimelate/putrescine_aminotransferase ArgD 31.0 0.032258064516129 0.967741935483871 0.0723436552430908 0.959213026436007 0.5157783408395489 0.8868693711929162 0 0 0 0 K09377 0.0028571428571428 0.0 CSRP; cysteine and glycine-rich protein 94.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG2451 Ribosomal_protein_L35AE/L33A Rpl35A 2.0 1.0 0.0 0 0 0 0 K09384 0.0514285714285714 0.1168091168091168 K09384; uncharacterized protein 83.0 34.0 20.0 7.0 0.507462686567164 L 20.0 47.0 12.0 0.432835820895522 COG0507 ATPase/5-3_helicase_helicase_subunit_RecD_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecD 67.0 0.2985074626865671 0.7014925373134329 0.23477237903981 0.249651376673064 0.242211877856437 0.014878997633254 0 0 0 0 K09386 0.1228571428571428 0.1481481481481481 K09386; uncharacterized protein 83.0 77.0 31.0 4.0 0.57037037037037 S 66.0 69.0 2.0 0.992592592592593 COG3427 Carbon_monoxide_dehydrogenase_subunit_CoxG CoxG 135.0 0.4888888888888889 0.5111111111111111 0.015312155447236 0.764086970800969 0.3896995631241025 0.748774815353733 0 0 0 0 K09388 0.0571428571428571 0.0256410256410256 K09388; uncharacterized protein 58.0 16.0 0.0 1.0 1.0 S 37.0 9.0 2.0 0.630434782608696 COG3465 Uncharacterized_conserved_protein_YwgA YwgA 46.0 0.8043478260869565 0.1956521739130435 0.0040987166576971 0.0124524005806739 0.0082755586191855 0.0083536839229768 0 0 0 0 K09456 0.0 0.1282051282051282 aidB; putative acyl-CoA dehydrogenase 442.0 41.0 21.0 2.0 0.672131147540984 I 0.0 61.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 61.0 0.0 1.0 0.0015824480118985 0.0759485771047555 0.038765512558327 0.074366129092857 0 0 0 0 K09457 0.0457142857142857 0.4501424501424501 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 81.0 92.0 52.0 5.0 0.525714285714286 S 16.0 159.0 2.0 0.982857142857143 COG0780 NADPH-dependent_7-cyano-7-deazaguanine_reductase_QueF,_C-terminal_domain,_T-fold_superfamily QueFC 175.0 0.0914285714285714 0.9085714285714286 0.0211378407536831 0.2796018601987 0.1503698504761915 0.2584640194450169 0 0 0 0 K09458 0.0142857142857142 0.8319088319088319 fabF, OXSM, CEM1; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] path:map00061,path:map00780,path:map01100,path:map01212,path:map01240 Fatty acid biosynthesis,Biotin metabolism,Metabolic pathways,Fatty acid metabolism,Biosynthesis of cofactors 166.0 384.0 249.0 4.0 0.724528301886792 I 5.0 525.0 3.0 0.992452830188679 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 530.0 0.0094339622641509 0.9905660377358492 0.036588179674035 0.437010492277813 0.236799335975924 0.400422312603778 0 0 0 0 K09459 0.0 0.0 E4.1.1.82; phosphonopyruvate decarboxylase [EC:4.1.1.82] path:map00440,path:map00998,path:map01100,path:map01110,path:map01120 Phosphonate and phosphinate metabolism,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 36.0 33.0 5.0 0.8 EH 0.0 0.0 3.0 0.755555555555556 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 0.0 0 0 0 0 K09461 0.02 0.0797720797720797 E1.14.13.40; anthraniloyl-CoA monooxygenase [EC:1.14.13.40] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 276.0 27.0 13.0 3.0 0.642857142857143 C 7.0 34.0 5.0 0.523809523809524 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 41.0 0.1707317073170731 0.8292682926829268 0.0587550305345316 0.714143685066903 0.3864493578007172 0.6553886545323714 0 0 0 0 K09469 0.0 0.0142450142450142 aepZ; 2-aminoethylphosphonate-pyruvate transaminase 350.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0075 Archaeal_aspartate_aminotransferase_or_a_related_aminotransferase,_includes_purine_catabolism_protein_PucG PucG 5.0 0.0 1.0 0.105398538104658 0.239406725722139 0.1724026319133985 0.134008187617481 0 0 0 0 K09470 0.0 0.0113960113960113 puuA; gamma-glutamylputrescine synthase [EC:6.3.1.11] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 448.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0174 Glutamine_synthetase GlnA 4.0 0.0 1.0 0.0560776206639967 0.134676504547715 0.0953770626058558 0.0785988838837182 0 0 0 0 K09471 0.0 0.1225071225071225 puuB, ordL; gamma-glutamylputrescine oxidase [EC:1.4.3.-] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 279.0 49.0 45.0 3.0 0.907407407407407 E 0.0 54.0 2.0 0.981481481481482 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 54.0 0.0 1.0 0.0219689402052493 0.201864768224904 0.1119168542150766 0.1798958280196547 0 0 0 0 K09472 0.0 0.0854700854700854 puuC, aldH; 4-(gamma-glutamylamino)butanal dehydrogenase [EC:1.2.1.99] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 464.0 44.0 0.0 1.0 1.0 C 0.0 44.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 44.0 0.0 1.0 0.0263239741083253 0.200917195047607 0.1136205845779661 0.1745932209392817 0 0 0 0 K09473 0.0 0.0028490028490028 puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 250.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2071 Gamma-glutamyl-gamma-aminobutyrate_hydrolase_PuuD_(putrescine_degradation),_contains_GATase1-like_domain PuuD 1.0 0.0 1.0 0 0 0 0 K09474 0.0 0.0455840455840455 phoN; acid phosphatase (class A) [EC:3.1.3.2] path:map00740,path:map01100,path:map02020 Riboflavin metabolism,Metabolic pathways,Two-component system 87.0 24.0 0.0 1.0 1.0 I 0.0 24.0 1.0 1.0 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 24.0 0.0 1.0 0.0038960850284353 0.0181137352907367 0.011004910159586 0.0142176502623014 0 0 0 0 K09475 0.0 0.0056980056980056 ompC; outer membrane pore protein C path:map01501,path:map02020 beta-Lactam resistance,Two-component system 343.0 10.0 0.0 1.0 1.0 M 0.0 10.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 10.0 0.0 1.0 2.1624398802771e-12 3.78301194967555e-12 2.9727259149763248e-12 1.6205720693984498e-12 0 0 0 0 K09476 0.0 0.0199430199430199 ompF; outer membrane pore protein F path:map01501,path:map02020 beta-Lactam resistance,Two-component system 192.0 19.0 0.0 1.0 1.0 M 0.0 19.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 19.0 0.0 1.0 0.0043407162186167 0.0088551568299806 0.0065979365242986 0.0045144406113638 0 0 0 0 K09477 0.0142857142857142 0.0284900284900284 citT; citrate:succinate antiporter path:map02020 Two-component system 428.0 15.0 0.0 1.0 1.0 P 5.0 10.0 1.0 1.0 COG0471 Di-_and_tricarboxylate_antiporter CitT 15.0 0.3333333333333333 0.6666666666666666 0.465568332337386 0.34005136844003 0.402809850388708 0.125516963897356 0 0 0 0 K09478 0.0 0.0113960113960113 ACADSB; short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] path:map00071,path:map00280,path:map01100,path:map01110,path:map01212 Fatty acid degradation,Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Fatty acid metabolism 98.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 4.0 0.0 1.0 7.99522714075696e-13 1.24825780524635e-08 6.2416887875887875e-09 1.2481778529749424e-08 0 0 0 0 K09482 0.8771428571428571 0.0 gatD; glutamyl-tRNA(Gln) amidotransferase subunit D [EC:6.3.5.7] path:map00970,path:map01100 Aminoacyl-tRNA biosynthesis,Metabolic pathways 291.0 278.0 237.0 2.0 0.871473354231975 J 319.0 0.0 1.0 1.0 COG0252 L-asparaginase/archaeal_Glu-tRNAGln_amidotransferase_subunit_D AnsA 319.0 1.0 0.0 0.59924444860558 0.963699193617816 0.781471821111698 0.3644547450122359 0 0 0 1 K09483 0.0028571428571428 0.0142450142450142 quiC; 3-dehydroshikimate dehydratase [EC:4.2.1.118] path:map01053,path:map01100,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Metabolic pathways,Biosynthesis of secondary metabolites 393.0 5.0 4.0 2.0 0.833333333333333 P 1.0 5.0 1.0 1.0 COG3420 Nitrous_oxide_reductase_accessory_protein_NosD,_contains_tandem_CASH_domains NosD 6.0 0.1666666666666666 0.8333333333333334 0.092730847195642 0.195655718564001 0.1441932828798215 0.102924871368359 0 0 0 0 K09488 0.0 0.0028490028490028 TRAP1, HSP75; TNF receptor-associated protein 1 path:map05012,path:map05022 Parkinson disease,Pathways of neurodegeneration - multiple diseases 571.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0326 Molecular_chaperone,_HSP90_family HtpG 1.0 0.0 1.0 0 0 0 0 K09490 0.0 0.0028490028490028 HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:3.6.4.10] path:map03060,path:map04141,path:map04612,path:map04918,path:map05012,path:map05014,path:map05020,path:map05022,path:map05417 Protein export,Protein processing in endoplasmic reticulum,Antigen processing and presentation,Thyroid hormone synthesis,Parkinson disease,Amyotrophic lateral sclerosis,Prion disease,Pathways of neurodegeneration - multiple diseases,Lipid and atherosclerosis 213.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 1.0 0.0 1.0 0 0 0 0 K09508 0.0028571428571428 0.0028490028490028 DNAJB2; DnaJ homolog subfamily B member 2 path:map04141 Protein processing in endoplasmic reticulum 148.0 2.0 0.0 1.0 1.0 O 1.0 1.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 2.0 0.5 0.5 0 0 0 0 K09509 0.0028571428571428 0.0 DNAJB3; DnaJ homolog subfamily B member 3 239.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 1.0 1.0 0.0 0 0 0 0 K09512 0.0028571428571428 0.0056980056980056 DNAJB6; DnaJ homolog subfamily B member 6 159.0 3.0 0.0 1.0 1.0 O 1.0 2.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K09515 0.0028571428571428 0.0 DNAJB9; DnaJ homolog subfamily B member 9 145.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 1.0 1.0 0.0 0 0 0 0 K09516 0.0428571428571428 0.0911680911680911 RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23] path:map00830 Retinol metabolism 128.0 58.0 54.0 2.0 0.935483870967742 Q 25.0 37.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 62.0 0.4032258064516129 0.5967741935483871 0.0254634333509554 0.0327361277277739 0.0290997805393646 0.0072726943768185 0 0 0 0 K09525 0.0057142857142857 0.0 DNAJC5; DnaJ homolog subfamily C member 5 path:map04141 Protein processing in endoplasmic reticulum 51.0 2.0 0.0 1.0 1.0 O 2.0 0.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 2.0 1.0 0.0 0 0 0 0 K09527 0.0028571428571428 0.0 DNAJC7; DnaJ homolog subfamily C member 7 228.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 1.0 1.0 0.0 0 0 0 0 K09530 0.0028571428571428 0.0 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-] path:map04141 Protein processing in endoplasmic reticulum 163.0 1.0 0.0 1.0 1.0 OQ 1.0 0.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 1.0 1.0 0.0 0 0 0 0 K09531 0.0 0.0028490028490028 DNAJC11; DnaJ homolog subfamily C member 11 276.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 1.0 0.0 1.0 0 0 0 0 K09537 0.0028571428571428 0.0 DNAJC17; DnaJ homolog subfamily C member 17 239.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG2214 Curved_DNA-binding_protein_CbpA,_contains_a_DnaJ-like_domain CbpA 1.0 1.0 0.0 0 0 0 0 K09553 0.0028571428571428 0.0056980056980056 STIP1; stress-induced-phosphoprotein 1 path:map05020 Prion disease 148.0 2.0 1.0 2.0 0.666666666666667 O 1.0 2.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K09557 0.0057142857142857 0.0 BAG3; BCL2-associated athanogene 3 42.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG2126 Ribosomal_protein_L37E RPL37A 2.0 1.0 0.0 0 0 0 0 K09565 0.0085714285714285 0.0626780626780626 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8] path:map04020,path:map04022,path:map04613,path:map05010,path:map05012,path:map05016,path:map05017,path:map05020,path:map05022,path:map05145,path:map05208,path:map05415 Calcium signaling pathway,cGMP-PKG signaling pathway,Neutrophil extracellular trap formation,Alzheimer disease,Parkinson disease,Huntington disease,Spinocerebellar ataxia,Prion disease,Pathways of neurodegeneration - multiple diseases,Toxoplasmosis,Chemical carcinogenesis - reactive oxygen species,Diabetic cardiomyopathy 138.0 25.0 19.0 2.0 0.806451612903226 O 3.0 28.0 2.0 0.935483870967742 COG0652 Peptidyl-prolyl_cis-trans_isomerase_(rotamase)_-_cyclophilin_family PpiB 31.0 0.0967741935483871 0.9032258064516128 0.0211499539198006 0.0556679642781418 0.0384089590989712 0.0345180103583412 0 0 0 0 K09568 0.0 0.0028490028490028 FKBP1; FK506-binding protein 1 [EC:5.2.1.8] 109.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 1.0 0.0 1.0 0 0 0 0 K09569 0.0 0.0028490028490028 FKBP2; FK506-binding protein 2 [EC:5.2.1.8] 158.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 1.0 0.0 1.0 0 0 0 0 K09577 0.0 0.0028490028490028 FKBP14; FK506-binding protein 14 [EC:5.2.1.8] 158.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 1.0 0.0 1.0 0 0 0 0 K09583 0.0028571428571428 0.0 PDIA5; protein disulfide-isomerase A5 [EC:5.3.4.1] 457.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 1.0 1.0 0.0 0 0 0 0 K09584 0.0028571428571428 0.0 PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1] path:map04141 Protein processing in endoplasmic reticulum 111.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 1.0 1.0 0.0 0 0 0 0 K09595 0.0142857142857142 0.0 HM13; minor histocompatibility antigen H13 [EC:3.4.23.-] 131.0 5.0 0.0 1.0 1.0 C 5.0 0.0 1.0 1.0 KOG2443 5.0 1.0 0.0 0.0005933282719819 0.0009768927201351 0.0007851104960584 0.0003835644481532 0 0 0 0 K09607 0.0228571428571428 0.0598290598290598 ina; immune inhibitor A [EC:3.4.24.-] 211.0 17.0 8.0 5.0 0.53125 S 8.0 24.0 3.0 0.875 COG4412 Bacillopeptidase_F,_M6_metalloprotease_family 32.0 0.25 0.75 0.643288511326037 0.125273891494835 0.384281201410436 0.518014619831202 0 1 0 1 K09612 0.02 0.0085470085470085 iap; alkaline phosphatase isozyme conversion protein [EC:3.4.11.-] 323.0 11.0 10.0 2.0 0.916666666666667 DZ 9.0 3.0 1.0 1.0 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 12.0 0.75 0.25 0.858600158533627 0.915162637189366 0.8868813978614964 0.0565624786557389 0 0 1 1 K09613 0.0257142857142857 0.0 COPS5, CSN5; COP9 signalosome complex subunit 5 [EC:3.4.-.-] 126.0 12.0 0.0 1.0 1.0 OT 12.0 0.0 1.0 1.0 COG1310 Proteasome_lid_subunit_RPN8/RPN11,_contains_Jab1/MPN_domain_metalloenzyme_(JAMM)_motif Rri1 12.0 1.0 0.0 0.861307529120888 0.762994834007668 0.812151181564278 0.09831269511322 0 0 1 1 K09628 0.0 0.0028490028490028 PRSS27; serine protease 27 [EC:3.4.21.-] 540.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 1.0 0.0 1.0 0 0 0 0 K09630 0.0 0.0028490028490028 PRSS36; polyserase 2 [EC:3.4.21.-] 540.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 1.0 0.0 1.0 0 0 0 0 K09640 0.0 0.0028490028490028 TMPRSS9; transmembrane protease serine 9 [EC:3.4.21.-] 540.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG5640 Secreted_trypsin-like_serine_protease 1.0 0.0 1.0 0 0 0 0 K09647 0.0028571428571428 0.0 IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-] path:map03060 Protein export 150.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0681 Signal_peptidase_I LepB 1.0 1.0 0.0 0 0 0 0 K09650 0.0085714285714285 0.0712250712250712 PARL, PSARL, PCP1; rhomboid-like protein [EC:3.4.21.105] 165.0 28.0 0.0 1.0 1.0 S 3.0 25.0 1.0 1.0 COG0705 Membrane-associated_serine_protease,_rhomboid_family GlpG 28.0 0.1071428571428571 0.8928571428571429 0.0012331218445923 0.0010825063656361 0.0011578141051142 0.0001506154789562 0 0 0 0 K09680 0.0628571428571428 0.0541310541310541 PANK1_2_3, CAB1, coaW; type II pantothenate kinase [EC:2.7.1.33] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 126.0 16.0 1.0 4.0 0.380952380952381 S 23.0 19.0 3.0 0.404761904761905 COG5146 Pantothenate_kinase PanK 42.0 0.5476190476190477 0.4523809523809524 0.929613714374551 0.84932425178439 0.8894689830794704 0.080289462590161 1 1 1 1 K09681 0.0 0.0541310541310541 gltC; LysR family transcriptional regulator, transcription activator of glutamate synthase operon 247.0 23.0 0.0 1.0 1.0 K 0.0 23.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 23.0 0.0 1.0 0.0049755141344486 0.286292618204925 0.1456340661696868 0.2813171040704764 0 0 0 0 K09682 0.0 0.0142450142450142 hpr; MarR family transcriptional regulator, protease production regulatory protein HPr 176.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 6.0 0.0 1.0 2.95042537854144e-06 3.66420261643866e-06 3.30731399749005e-06 7.137772378972198e-07 0 0 0 0 K09683 0.0 0.0199430199430199 hutP; hut operon positive regulatory protein 121.0 6.0 2.0 2.0 0.6 K 0.0 10.0 2.0 0.6 28T9W 10.0 0.0 1.0 0.0189467187346328 0.35894641460206 0.1889465666683464 0.3399996958674272 0 0 0 0 K09684 0.0 0.1452991452991453 pucR; PucR family transcriptional regulator, purine catabolism regulatory protein 155.0 80.0 67.0 4.0 0.73394495412844 QT 0.0 109.0 4.0 0.834862385321101 COG2508 DNA-binding_transcriptional_regulator,_PucR/PutR_family PucR 109.0 0.0 1.0 0.0009747136309754 0.754975232893837 0.3779749732624062 0.7540005192628615 0 0 0 0 K09685 0.2 0.0968660968660968 purR; purine operon repressor 150.0 115.0 0.0 1.0 1.0 F 81.0 34.0 1.0 1.0 COG0503 Adenine/guanine_phosphoribosyltransferase_or_related_PRPP-binding_protein Apt 115.0 0.7043478260869566 0.2956521739130435 0.963193556018991 0.670192087320252 0.8166928216696215 0.293001468698739 1 1 1 1 K09688 0.0 0.0683760683760683 kpsM; capsular polysaccharide transport system permease protein path:map02010 ABC transporters 187.0 26.0 25.0 2.0 0.962962962962963 GM 0.0 27.0 1.0 1.0 COG1682 ABC-type_polysaccharide/teichoic_acid/polyol_phosphate_export_permease TagG 27.0 0.0 1.0 0.0215160379948654 0.0465673993996175 0.0340417186972414 0.0250513614047521 0 0 0 0 K09689 0.0085714285714285 0.1082621082621082 kpsT; capsular polysaccharide transport system ATP-binding protein [EC:7.6.2.12] path:map02010 ABC transporters 161.0 54.0 52.0 2.0 0.964285714285714 GM 3.0 53.0 2.0 0.964285714285714 COG1134 ABC-type_polysaccharide/polyol_phosphate_transport_system,_ATPase_component TagH 56.0 0.0535714285714285 0.9464285714285714 0.0129027400195588 0.0591448704154089 0.0360238052174838 0.04624213039585 0 0 0 0 K09690 0.0914285714285714 0.3076923076923077 wzm, rfbA; lipopolysaccharide transport system permease protein path:map02010 ABC transporters 126.0 130.0 87.0 5.0 0.593607305936073 GM 39.0 179.0 4.0 0.986301369863014 COG1682 ABC-type_polysaccharide/teichoic_acid/polyol_phosphate_export_permease TagG 218.0 0.1788990825688073 0.8211009174311926 0.06603018714636 0.520831279729893 0.2934307334381265 0.4548010925835329 0 0 0 0 K09691 0.1142857142857142 0.3646723646723647 wzt, rbfB; lipopolysaccharide transport system ATP-binding protein path:map02010 ABC transporters 139.0 202.0 171.0 6.0 0.827868852459016 GM 50.0 194.0 5.0 0.959016393442623 COG1134 ABC-type_polysaccharide/polyol_phosphate_transport_system,_ATPase_component TagH 244.0 0.2049180327868852 0.7950819672131147 0.218548116675506 0.856709055643895 0.5376285861597005 0.638160938968389 0 0 0 0 K09692 0.0085714285714285 0.0911680911680911 tagG; teichoic acid transport system permease protein path:map02010 ABC transporters 196.0 30.0 23.0 3.0 0.789473684210526 GM 3.0 35.0 1.0 1.0 COG1682 ABC-type_polysaccharide/teichoic_acid/polyol_phosphate_export_permease TagG 38.0 0.0789473684210526 0.9210526315789472 0.0271730041149205 0.47748777820439 0.2523303911596552 0.4503147740894694 0 0 0 0 K09693 0.0057142857142857 0.1396011396011396 tagH; teichoic acid transport system ATP-binding protein [EC:7.5.2.4] path:map02010 ABC transporters 206.0 54.0 51.0 2.0 0.947368421052632 GM 2.0 55.0 1.0 1.0 COG1134 ABC-type_polysaccharide/polyol_phosphate_transport_system,_ATPase_component TagH 57.0 0.0350877192982456 0.9649122807017544 0.0266618524452327 0.94942658679734 0.4880442196212863 0.9227647343521074 0 0 0 0 K09694 0.0542857142857142 0.1025641025641025 nodJ; lipooligosaccharide transport system permease protein path:map02010 ABC transporters 223.0 47.0 31.0 3.0 0.734375 V 19.0 45.0 1.0 1.0 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 64.0 0.296875 0.703125 0.418499879242836 0.554709041427812 0.486604460335324 0.1362091621849759 0 0 0 0 K09695 0.0971428571428571 0.1737891737891738 nodI; lipooligosaccharide transport system ATP-binding protein path:map02010 ABC transporters 206.0 99.0 83.0 3.0 0.846153846153846 V 42.0 75.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 117.0 0.358974358974359 0.6410256410256411 0.166467656116437 0.562715947811949 0.364591801964193 0.396248291695512 0 0 0 0 K09696 0.0228571428571428 0.1168091168091168 natB; sodium transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 192.0 55.0 46.0 2.0 0.859375 CP 8.0 56.0 2.0 0.609375 COG1668 ABC-type_Na+_efflux_pump,_permease_component_NatB NatB 64.0 0.125 0.875 0.0757489517712123 0.445588440342748 0.2606686960569802 0.3698394885715357 0 0 0 0 K09697 0.0257142857142857 0.1424501424501424 natA; sodium transport system ATP-binding protein [EC:7.2.2.4] path:map02010,path:map02020 ABC transporters,Two-component system 211.0 45.0 11.0 2.0 0.569620253164557 CP 9.0 70.0 2.0 0.569620253164557 COG4555 ABC-type_Na+_transport_system,_ATPase_component_NatA NatA 79.0 0.1139240506329113 0.8860759493670886 0.25157497054488 0.282549165694603 0.2670620681197415 0.0309741951497229 0 0 0 0 K09698 0.0 0.3361823361823361 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] path:map00970,path:map01100,path:map01240 Aminoacyl-tRNA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 333.0 138.0 0.0 1.0 1.0 J 0.0 138.0 1.0 1.0 COG0008 Glutamyl-_or_glutaminyl-tRNA_synthetase GlnS 138.0 0.0 1.0 0.672939711022205 0.607593216649945 0.640266463836075 0.0653464943722599 0 0 0 1 K09699 0.0485714285714285 0.1225071225071225 DBT, bkdB; 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] path:map00280,path:map00640,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 324.0 65.0 0.0 1.0 1.0 C 17.0 48.0 1.0 1.0 COG0508 Pyruvate/2-oxoglutarate_dehydrogenase_complex,_dihydrolipoamide_acyltransferase_(E2)_component AceF 65.0 0.2615384615384615 0.7384615384615385 0.0719291296892815 0.842512483767484 0.4572208067283827 0.7705833540782026 0 0 0 0 K09700 0.0428571428571428 0.0569800569800569 K09700; uncharacterized protein 80.0 36.0 0.0 1.0 1.0 S 17.0 21.0 1.0 1.0 COG3461 Uncharacterized_conserved_protein 38.0 0.4473684210526316 0.5526315789473685 0.788751028330493 0.311204375971689 0.549977702151091 0.477546652358804 1 1 1 1 K09701 0.0 0.1396011396011396 K09701; uncharacterized protein 168.0 50.0 0.0 1.0 1.0 S 0.0 50.0 1.0 1.0 COG3496 Uncharacterized_conserved_protein,_DUF1365_family 50.0 0.0 1.0 0.0051893017994501 0.0183149524202352 0.0117521271098426 0.0131256506207851 0 0 0 0 K09702 0.0142857142857142 0.0683760683760683 K09702; uncharacterized protein 107.0 25.0 19.0 5.0 0.735294117647059 S 9.0 25.0 3.0 0.705882352941177 COG3506 Regulation_of_enolase_protein_1_(function_unknown),_concanavalin_A-like_superfamily Ree1 34.0 0.2647058823529412 0.7352941176470589 0.0095348211394179 0.124692510808923 0.0671136659741704 0.1151576896695051 0 0 0 0 K09703 0.0942857142857142 0.0512820512820512 K09703; uncharacterized protein 262.0 88.0 0.0 1.0 1.0 S 50.0 38.0 1.0 1.0 COG3535 Uncharacterized_conserved_protein,_DUF917_family 88.0 0.5681818181818182 0.4318181818181818 0.807761308677355 0.899647733984501 0.853704521330928 0.091886425307146 1 1 1 1 K09704 0.0028571428571428 0.0569800569800569 K09704; uncharacterized protein 391.0 20.0 17.0 2.0 0.869565217391304 S 1.0 22.0 1.0 1.0 COG3538 Meiotically_up-regulated_gene_157_(Mug157)_protein_(function_unknown) 23.0 0.0434782608695652 0.9565217391304348 0.0150246394365605 0.0398932952338797 0.0274589673352201 0.0248686557973192 0 0 0 0 K09705 0.0171428571428571 0.1937321937321937 K09705; uncharacterized protein 70.0 66.0 60.0 4.0 0.857142857142857 S 6.0 71.0 5.0 0.857142857142857 COG3542 Predicted_sugar_epimerase,_cupin_superfamily CFF1 77.0 0.0779220779220779 0.922077922077922 0.0110338073900133 0.0194501375039043 0.0152419724469588 0.0084163301138909 0 0 0 0 K09706 0.0571428571428571 0.0284900284900284 K09706; uncharacterized protein 96.0 29.0 27.0 2.0 0.935483870967742 S 20.0 11.0 1.0 1.0 COG3543 Uncharacterized_conserved_protein,_DUF1284_domain 31.0 0.6451612903225806 0.3548387096774194 0.0422831030638816 0.0621954212151466 0.0522392621395141 0.019912318151265 0 0 0 0 K09707 0.06 0.0512820512820512 K09707; uncharacterized protein 101.0 41.0 0.0 1.0 1.0 S 22.0 19.0 1.0 1.0 COG3603 ACT_domain,_ACT-7_family ACT-7 41.0 0.5365853658536586 0.4634146341463415 0.035839037107743 0.385296668865118 0.2105678529864305 0.349457631757375 0 0 0 0 K09709 0.0028571428571428 0.0826210826210826 meh; 3-methylfumaryl-CoA hydratase [EC:4.2.1.153] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 208.0 35.0 33.0 2.0 0.945945945945946 S 1.0 36.0 2.0 0.945945945945946 COG3777 Hydroxyacyl-ACP_dehydratase_HTD2,_hotdog_domain HTD2 37.0 0.027027027027027 0.972972972972973 0.0065043451299727 0.0148757786843155 0.0106900619071441 0.0083714335543427 0 0 0 0 K09710 0.0 0.8575498575498576 ybeB; ribosome-associated protein 66.0 237.0 172.0 2.0 0.78476821192053 J 0.0 302.0 1.0 1.0 COG0799 Ribosomal_silencing_factor_RsfS,_regulates_association_of_30S_and_50S_subunits RsfS 302.0 0.0 1.0 0.119844874229492 0.514909972438968 0.3173774233342299 0.395065098209476 0 0 0 0 K09711 0.2057142857142857 0.0455840455840455 lipS1; lipoyl synthase path:map00785,path:map01100 Lipoic acid metabolism,Metabolic pathways 199.0 101.0 0.0 1.0 1.0 S 85.0 16.0 1.0 1.0 COG1856 Uncharacterized_conserved_protein,_radical_SAM_superfamily 101.0 0.8415841584158416 0.1584158415841584 0.921598097502858 0.950028717283603 0.9358134073932304 0.028430619780745 1 1 1 1 K09712 0.0371428571428571 0.0284900284900284 K09712; uncharacterized protein 53.0 20.0 0.0 1.0 1.0 S 14.0 12.0 1.0 1.0 COG3042 Putative_hemolysin Hlx 26.0 0.5384615384615384 0.4615384615384615 0.232135284621866 0.0523678651405162 0.1422515748811911 0.1797674194813498 0 0 0 0 K09713 0.24 0.0 K09713; uncharacterized protein 93.0 84.0 0.0 1.0 1.0 S 84.0 0.0 1.0 1.0 COG1255 Predicted_small_methyltransferase_MTH1000,_UPF0146_family MTH1000 84.0 1.0 0.0 0.393006507163557 0.652909491673048 0.5229579994183025 0.259902984509491 0 0 0 0 K09714 0.2142857142857142 0.0 tfx; HTH-type transcriptional regulator, fmd operon transcriptional regulator 120.0 84.0 0.0 1.0 1.0 K 84.0 0.0 1.0 1.0 COG1356 Transcriptional_regulator 84.0 1.0 0.0 0.0459575905372138 0.195056125889561 0.1205068582133874 0.1490985353523472 0 0 0 0 K09715 0.2685714285714285 0.0 K09715; uncharacterized protein 47.0 94.0 0.0 1.0 1.0 S 94.0 0.0 1.0 1.0 COG1531 Uncharacterized_conserved_protein,_UPF0248_family 94.0 1.0 0.0 0.58618826132796 0.740697744471194 0.663443002899577 0.1545094831432339 0 0 0 1 K09716 0.6971428571428572 0.0 dtdA, GEK1; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] 136.0 226.0 213.0 3.0 0.911290322580645 J 248.0 0.0 2.0 0.842741935483871 COG1650 D-tyrosyl-tRNA(Tyr)_deacylase 248.0 1.0 0.0 0.960324328401129 0.831182205849455 0.895753267125292 0.129142122551674 0 0 1 1 K09717 0.3114285714285714 0.0056980056980056 K09717; uncharacterized protein 126.0 142.0 0.0 1.0 1.0 S 149.0 2.0 1.0 1.0 COG1665 Predicted_nucleotidyltransferase_AF1967 AF1967 151.0 0.9867549668874172 0.0132450331125827 0.966694552458376 0.931024726424422 0.9488596394413992 0.0356698260339539 0 0 1 1 K09718 0.0257142857142857 0.0 K09718; uncharacterized protein 287.0 5.0 1.0 2.0 0.555555555555556 S 9.0 0.0 1.0 1.0 COG1667 Uncharacterized_conserved_protein_AF1501,_DUF2226_family AF1501 9.0 1.0 0.0 0.798157718017354 0.9046407878707 0.8513992529440271 0.1064830698533459 0 0 1 1 K09719 0.0542857142857142 0.0 K09719; uncharacterized protein 202.0 22.0 0.0 1.0 1.0 S 22.0 0.0 1.0 1.0 COG1689 Class_II_terpene_cyclase_family_protein_AF1543 AF1543 22.0 1.0 0.0 0.44096268333175 0.145371783617179 0.2931672334744645 0.295590899714571 0 0 0 0 K09720 0.1485714285714285 0.0398860398860398 nrpRI; HTH-type transcriptional regulator, global nitrogen regulator NrpRI 256.0 65.0 58.0 3.0 0.89041095890411 K 58.0 15.0 3.0 0.904109589041096 COG1693 Repressor_of_nif_and_glnA_expression 73.0 0.7945205479452054 0.2054794520547945 0.954420230349371 0.844321269331965 0.899370749840668 0.1100989610174059 1 1 1 1 K09721 0.6942857142857143 0.0 K09721; uncharacterized protein 60.0 245.0 0.0 1.0 1.0 S 245.0 0.0 1.0 1.0 COG1698 Uncharacterized_conserved_protein,_UPF0147_family 245.0 1.0 0.0 0.213243631178532 0.0526277657715748 0.1329356984750534 0.1606158654069572 0 0 0 0 K09722 0.5857142857142857 0.0028490028490028 K09722, pps; 4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36] path:map00410,path:map00770,path:map01100,path:map01240 beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 195.0 214.0 0.0 1.0 1.0 S 213.0 1.0 1.0 1.0 COG1701 Archaeal_phosphopantothenate_synthetase aPPS 214.0 0.9953271028037384 0.0046728971962616 0.700262626905262 0.704993049095169 0.7026278380002156 0.004730422189907 0 0 0 1 K09723 0.6 0.0 ginS; DNA replication factor GINS 13.0 200.0 160.0 3.0 0.75187969924812 L 264.0 0.0 3.0 0.695488721804511 COG1711 DNA_replication_initiation_complex_subunit,_GINS_family 264.0 1.0 0.0 0.018722513681773 0.0668747695584545 0.0427986416201137 0.0481522558766815 0 0 0 0 K09724 0.0657142857142857 0.0 K09724; uncharacterized protein 316.0 23.0 0.0 1.0 1.0 S 23.0 0.0 1.0 1.0 COG1771 Uncharacterized_conserved_protein,_contains_N-terminal_Zn-finger_domain 23.0 1.0 0.0 0.0005627259692195 0.0040032444375349 0.0022829852033772 0.0034405184683154 0 0 0 0 K09725 0.12 0.0 K09725; uncharacterized protein 157.0 43.0 0.0 1.0 1.0 S 43.0 0.0 1.0 1.0 COG1772 Uncharacterized_conserved_protein,_DUF531_domain 43.0 1.0 0.0 0.198437174115291 0.0078872935461328 0.1031622338307119 0.1905498805691582 0 0 0 0 K09726 0.3771428571428571 0.0541310541310541 K09726; uncharacterized protein 118.0 211.0 0.0 1.0 1.0 S 190.0 21.0 1.0 1.0 COG1817 Predicted_glycosyltransferase 211.0 0.9004739336492891 0.0995260663507109 0.764064805216463 0.949495401293743 0.856780103255103 0.1854305960772799 1 1 1 1 K09727 0.0942857142857142 0.0 K09727; uncharacterized protein 110.0 33.0 0.0 1.0 1.0 S 33.0 0.0 1.0 1.0 COG1844 Uncharacterized_conserved_protein,_DUF356_domain 33.0 1.0 0.0 0.570556650615033 0.443894552465707 0.50722560154037 0.126662098149326 0 0 0 1 K09728 0.5885714285714285 0.0 K09728; uncharacterized protein 51.0 188.0 170.0 2.0 0.912621359223301 S 206.0 0.0 1.0 1.0 COG1849 Uncharacterized_conserved_protein 206.0 1.0 0.0 0.0091924485828359 0.0016215233466366 0.0054069859647362 0.0075709252361993 0 0 0 0 K09729 0.2114285714285714 0.0911680911680911 K09729; uncharacterized protein 114.0 124.0 0.0 1.0 1.0 S 92.0 32.0 2.0 0.991935483870968 COG1852 Predicted_redox_protein_with_CxxCxxC_motif,_DUF116_family 124.0 0.7419354838709677 0.2580645161290322 0.67593997166783 0.433802036363867 0.5548710040158485 0.242137935303963 0 1 0 1 K09730 0.4571428571428571 0.0 K09730; uncharacterized protein 85.0 161.0 0.0 1.0 1.0 S 161.0 0.0 1.0 1.0 COG1860 Predicted_metal-binding_protein,_contains_two_cysteine_clusters,_UPF0179_family 161.0 1.0 0.0 0.0855188959823384 0.0983612407916626 0.0919400683870005 0.0128423448093241 0 0 0 0 K09731 0.2485714285714285 0.0 K09731; uncharacterized protein 113.0 88.0 0.0 1.0 1.0 S 88.0 0.0 1.0 1.0 COG1885 Uncharacterized_conserved_protein,_UPF0212_family 88.0 1.0 0.0 0.156383918183843 0.0192379133971794 0.0878109157905112 0.1371460047866636 0 0 0 0 K09732 0.3942857142857143 0.0028490028490028 K09732; uncharacterized protein 82.0 140.0 0.0 1.0 1.0 S 139.0 1.0 1.0 1.0 COG1888 Uncharacterized_conserved_protein,_DUF211_domain 140.0 0.9928571428571428 0.0071428571428571 0.878595416804162 0.47606149321188 0.677328455008021 0.4025339235922819 0 0 1 1 K09733 0.2085714285714285 0.0056980056980056 mfnB; (5-formylfuran-3-yl)methyl phosphate synthase [EC:4.2.3.153] path:map00680,path:map01100,path:map01240 Methane metabolism,Metabolic pathways,Biosynthesis of cofactors 215.0 74.0 72.0 2.0 0.973684210526316 H 74.0 2.0 1.0 1.0 COG1891 4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate_synthase_MfnB MfnB 76.0 0.9736842105263158 0.0263157894736842 0.98500440147195 0.983150733089371 0.9840775672806604 0.001853668382579 0 0 1 1 K09735 0.7228571428571429 0.0085470085470085 dpck; GTP-dependent dephospho-CoA kinase [EC:2.7.1.237] path:map00770,path:map01100 Pantothenate and CoA biosynthesis,Metabolic pathways 48.0 220.0 169.0 2.0 0.811808118081181 S 268.0 3.0 2.0 0.952029520295203 COG1909 Archaeal_dephospho-CoA_kinase DPCK 271.0 0.988929889298893 0.011070110701107 0.061965830296702 0.193737593883881 0.1278517120902915 0.131771763587179 0 0 0 0 K09736 0.4742857142857143 0.0 K09736; uncharacterized protein 85.0 152.0 136.0 2.0 0.904761904761905 S 168.0 0.0 1.0 1.0 COG1931 Predicted_RNA_binding_protein_with_dsRBD_fold,_UPF0201_family 168.0 1.0 0.0 0.0860561533802702 0.815849876906741 0.4509530151435056 0.7297937235264709 0 0 0 0 K09737 0.2657142857142857 0.0 K09737; uncharacterized protein 72.0 94.0 0.0 1.0 1.0 S 94.0 0.0 1.0 1.0 COG2083 Uncharacterized_conserved_protein,_UPF0216_family 94.0 1.0 0.0 0.762607981380978 0.930452578058705 0.8465302797198415 0.167844596677727 0 0 1 1 K09738 0.5085714285714286 0.0 K09738; uncharacterized protein 104.0 180.0 0.0 1.0 1.0 S 180.0 0.0 1.0 1.0 COG2090 Uncharacterized_conserved_protein,_DUF371_domain 180.0 1.0 0.0 0.143473925202243 0.267774601400443 0.205624263301343 0.1243006761982 0 0 0 0 K09739 0.36 0.0 mptD; dihydroneopterin aldolase [EC:4.1.2.25] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 92.0 128.0 0.0 1.0 1.0 S 128.0 0.0 1.0 1.0 COG2098 7,8-dihydroneopterin_aldolase_MptD_(tetrahydrofolate_and_tetrahydromethanopterin_biosynthesis) MptD 128.0 1.0 0.0 0.231358762892991 0.0755771268596618 0.1534679448763264 0.1557816360333292 0 0 0 0 K09740 0.2285714285714285 0.0968660968660968 K09740; uncharacterized protein 158.0 114.0 0.0 1.0 1.0 S 80.0 34.0 1.0 1.0 COG2122 Uncharacterized_conserved_protein,_UPF0280_family,_ApbE_superfamily 114.0 0.7017543859649122 0.2982456140350877 0.666134103481909 0.882109393521505 0.774121748501707 0.2159752900395959 0 1 0 1 K09741 0.4571428571428571 0.0 pcc1; KEOPS complex subunit Pcc1 48.0 160.0 0.0 1.0 1.0 S 160.0 0.0 1.0 1.0 COG2892 tRNA_threonylcarbamoyladenosine_modification_(KEOPS)_complex,__Pcc1_subunit Pcc1 160.0 1.0 0.0 0.510371069564942 0.749406602276338 0.62988883592064 0.239035532711396 0 0 0 1 K09742 0.1171428571428571 0.0 K09742; uncharacterized protein 148.0 41.0 0.0 1.0 1.0 S 41.0 0.0 1.0 1.0 COG3286 Uncharacterized_conserved_protein,_DUF2067_domain 41.0 1.0 0.0 0.0159271126971446 0.0135615109172286 0.0147443118071865 0.002365601779916 0 0 0 0 K09743 0.3971428571428571 0.0 K09743; uncharacterized protein 101.0 139.0 0.0 1.0 1.0 S 139.0 0.0 1.0 1.0 COG3365 Uncharacterized_conserved_protein,_DUF2073_family 139.0 1.0 0.0 0.682161335686987 0.974328970349084 0.8282451530180355 0.2921676346620969 0 0 0 1 K09744 0.2971428571428571 0.0683760683760683 K09744; uncharacterized protein 263.0 116.0 84.0 2.0 0.783783783783784 L 124.0 24.0 1.0 1.0 COG3372 Predicted_nuclease_of_restriction_endonuclease-like_(RecB)_superfamily,_implicated_in_nucleotide_excision_repair 148.0 0.8378378378378378 0.1621621621621621 0.22482570644584 0.0310763046236327 0.1279510055347363 0.1937494018222073 0 0 0 0 K09745 0.0628571428571428 0.0 K09745; uncharacterized protein 92.0 21.0 13.0 2.0 0.724137931034483 K 29.0 0.0 1.0 1.0 COG3373 Predicted_transcriptional_regulator,_contains_HTH_domain 29.0 1.0 0.0 0.106229241422084 0.619950146164042 0.363089693793063 0.513720904741958 0 0 0 0 K09746 0.4714285714285714 0.0 K09746; uncharacterized protein 86.0 238.0 237.0 2.0 0.99581589958159 S 239.0 0.0 1.0 1.0 COG3390 Replication_protein_A_(RPA)_family_protein 239.0 1.0 0.0 0.0033810360984509 0.313045509710334 0.1582132729043924 0.3096644736118831 0 0 0 0 K09747 0.0142857142857142 0.8005698005698005 ebfC; nucleoid-associated protein EbfC 64.0 232.0 180.0 2.0 0.816901408450704 S 5.0 284.0 2.0 0.982698961937716 COG0718 DNA-binding_nucleoid-associated_protein_YbaB/EfbC YbaB 289.0 0.0173010380622837 0.9826989619377162 0.0051839387403405 0.120788596433773 0.0629862675870567 0.1156046576934325 0 0 0 0 K09748 0.0 0.7692307692307693 rimP; ribosome maturation factor RimP 51.0 156.0 42.0 2.0 0.577777777777778 S 0.0 270.0 2.0 0.996296296296296 COG0779 Ribosome_maturation_factor_RimP RimP 270.0 0.0 1.0 0.0002550621893668 0.024029449500065 0.0121422558447159 0.0237743873106982 0 0 0 0 K09749 0.0057142857142857 0.2165242165242165 K09749; uncharacterized protein 49.0 113.0 107.0 6.0 0.843283582089552 L 2.0 132.0 7.0 0.843283582089552 COG1315 Flagellar_assembly_protein_FapA,_interacts_with_EIIAGlc FapA 134.0 0.0149253731343283 0.9850746268656716 0.381700234421147 0.71172008192347 0.5467101581723085 0.330019847502323 0 0 0 0 K09753 0.0028571428571428 0.0 CCR; cinnamoyl-CoA reductase [EC:1.2.1.44] path:map00940,path:map01100,path:map01110 Phenylpropanoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 345.0 1.0 0.0 1.0 1.0 V 1.0 0.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 1.0 1.0 0.0 0 0 0 0 K09758 0.0028571428571428 0.0256410256410256 asdA; aspartate 4-decarboxylase [EC:4.1.1.12] path:map00250,path:map00270,path:map01100,path:map01230 Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids 521.0 10.0 0.0 1.0 1.0 E 1.0 9.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 10.0 0.1 0.9 0.100100025031146 0.513498708567407 0.3067993667992765 0.4133986835362609 0 0 0 0 K09759 0.7142857142857143 0.0797720797720797 aspC, aspS; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23] path:map00970 Aminoacyl-tRNA biosynthesis 338.0 292.0 0.0 1.0 1.0 J 261.0 31.0 1.0 1.0 COG0017 Aspartyl/asparaginyl-tRNA_synthetase AsnS 292.0 0.8938356164383562 0.1061643835616438 0.541906345855506 0.593980463059989 0.5679434044577475 0.0520741172044829 0 1 0 1 K09760 0.1114285714285714 0.6239316239316239 rmuC; DNA recombination protein RmuC 109.0 247.0 234.0 5.0 0.908088235294117 S 43.0 229.0 2.0 0.996323529411765 COG1322 DNA_anti-recombination_protein_(rearrangement_mutator)_RmuC RmuC 272.0 0.1580882352941176 0.8419117647058824 0.0094249670174687 0.443367054831532 0.2263960109245003 0.4339420878140633 0 0 0 0 K09761 0.0028571428571428 0.8262108262108262 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] 70.0 304.0 303.0 2.0 0.99672131147541 J 1.0 304.0 1.0 1.0 COG1385 16S_rRNA_U1498_N3-methylase_RsmE RsmE 305.0 0.0032786885245901 0.99672131147541 0.0613473476393324 0.400569517726641 0.2309584326829867 0.3392221700873086 0 0 0 0 K09762 0.0 0.2706552706552707 whiA; cell division protein WhiA 243.0 97.0 0.0 1.0 1.0 K 0.0 97.0 1.0 1.0 COG1481 DNA-binding_transcriptional_regulator_WhiA,_involved_in_cell_division WhiA 97.0 0.0 1.0 0.113264394276423 0.0029247235346936 0.0580945589055583 0.1103396707417294 0 0 0 0 K09763 0.2171428571428571 0.2051282051282051 K09763; uncharacterized protein 39.0 147.0 140.0 2.0 0.954545454545455 S 76.0 78.0 2.0 0.974025974025974 COG1547 Predicted_metal-dependent_hydrolase YpuF 154.0 0.4935064935064935 0.5064935064935064 0.003246256646204 0.007131549734569 0.0051889031903865 0.003885293088365 0 0 0 0 K09764 0.0 0.3276353276353276 K09764; uncharacterized protein 57.0 99.0 83.0 2.0 0.860869565217391 S 0.0 115.0 1.0 1.0 COG1550 Stress-induced_protein_YlxP,_DUF503_family YlxP 115.0 0.0 1.0 0.0874437950947847 0.741611254208116 0.4145275246514504 0.6541674591133313 0 0 0 0 K09765 0.0285714285714285 0.2478632478632478 queH; epoxyqueuosine reductase [EC:1.17.99.6] 127.0 97.0 0.0 1.0 1.0 C 10.0 87.0 1.0 1.0 COG1636 Epoxyqueuosine_reductase_QueH_(tRNA_modification) QueH 97.0 0.1030927835051546 0.8969072164948454 0.607362813594185 0.540964221624118 0.5741635176091515 0.066398591970067 0 1 0 1 K09766 0.0142857142857142 0.0769230769230769 K09766; uncharacterized protein 67.0 19.0 13.0 4.0 0.59375 S 5.0 31.0 4.0 0.638888888888889 COG1655 Uncharacterized_conserved_protein,_DUF2225_family 36.0 0.1388888888888889 0.8611111111111112 0.105942772196843 0.520826694245525 0.313384733221184 0.4148839220486819 0 0 0 0 K09767 0.0 0.3618233618233618 yajQ; cyclic-di-GMP-binding protein 147.0 127.0 0.0 1.0 1.0 S 0.0 127.0 1.0 1.0 COG1666 Cyclic_di-GMP-binding_protein_YajQ,_UPF0234_family YajQ 127.0 0.0 1.0 0.0037658346219437 0.569281413766013 0.2865236241939783 0.5655155791440694 0 0 0 0 K09768 0.0 0.2649572649572649 K09768; uncharacterized protein 113.0 92.0 90.0 3.0 0.968421052631579 S 0.0 95.0 1.0 1.0 COG1671 Uncharacterized_conserved_protein_YaiI,_UPF0178_family YaiI 95.0 0.0 1.0 0.0014099305267191 0.0436481401579054 0.0225290353423122 0.0422382096311862 0 0 0 0 K09769 0.0 0.452991452991453 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16] path:map00230,path:map00240,path:map01100 Purine metabolism,Pyrimidine metabolism,Metabolic pathways 207.0 165.0 0.0 1.0 1.0 S 0.0 165.0 1.0 1.0 COG1692 2',3'-_and_3',5'-cNMP_phosphodiesterase_YmdB,_calcineurin_family YmdB 165.0 0.0 1.0 0.105405154202674 0.649535723564735 0.3774704388837045 0.544130569362061 0 0 0 0 K09770 0.0 0.0883190883190883 K09770; uncharacterized protein 97.0 32.0 0.0 1.0 1.0 S 0.0 32.0 1.0 1.0 COG1728 Uncharacterized_conserved_protein_YaaR,_TM1646/DUF327_family YaaR 32.0 0.0 1.0 0.015961439388899 0.647521540883568 0.3317414901362335 0.6315601014946689 0 0 0 0 K09771 0.02 0.1737891737891738 TC.SMR3; small multidrug resistance family-3 protein 101.0 74.0 69.0 2.0 0.936708860759494 S 14.0 66.0 2.0 0.9875 COG1742 Uncharacterized_inner_membrane_protein_YnfA,_drug/metabolite_transporter_superfamily YnfA 80.0 0.175 0.825 0.0046297471899321 0.518321024690654 0.261475385940293 0.5136912775007219 0 0 0 0 K09772 0.0 0.2962962962962963 sepF; cell division inhibitor SepF 66.0 109.0 0.0 1.0 1.0 D 0.0 109.0 1.0 1.0 COG1799 Cell_division_protein_SepF/YlmF,_interacts_with_FtsZ SepF 109.0 0.0 1.0 0.0481086866463787 0.0334934071497286 0.0408010468980536 0.01461527949665 0 0 0 0 K09773 0.0 0.3105413105413105 ppsR; [pyruvate, water dikinase]-phosphate phosphotransferase / [pyruvate, water dikinase] kinase [EC:2.7.4.28 2.7.11.33] 200.0 75.0 50.0 3.0 0.641025641025641 S 0.0 117.0 1.0 1.0 COG1806 Regulator_of_PEP_synthase_PpsR,_kinase-PPPase_family_(combines_ADP:protein_kinase_and_phosphorylase_activities) PpsR 117.0 0.0 1.0 0.0022464707132475 0.117666300778902 0.0599563857460747 0.1154198300656545 0 0 0 0 K09774 0.0 0.3817663817663818 lptA; lipopolysaccharide export system protein LptA 6.0 103.0 72.0 5.0 0.651898734177215 S 0.0 154.0 7.0 0.70253164556962 COG1934 Lipopolysaccharide_export_system_protein_LptA LptA 154.0 0.0 1.0 0.0140153651715221 0.0249804912720636 0.0194979282217928 0.0109651261005415 0 0 0 0 K09775 0.0285714285714285 0.2193732193732193 K09775; uncharacterized protein 107.0 89.0 87.0 2.0 0.978021978021978 S 10.0 81.0 1.0 1.0 COG1963 Acid_phosphatase_family_membrane_protein_YuiD YuiD 91.0 0.1098901098901098 0.8901098901098901 0.0498060551272228 0.756039460909323 0.4029227580182729 0.7062334057821001 0 0 0 0 K09776 0.0 0.1082621082621082 K09776; uncharacterized protein 115.0 38.0 0.0 1.0 1.0 S 0.0 38.0 1.0 1.0 COG1978 Predicted_RNase_H-related_nuclease_YkuK,_DUF458_family YkuK 38.0 0.0 1.0 0.0379224168776626 0.87383846146868 0.4558804391731713 0.8359160445910174 0 0 0 0 K09777 0.0 0.2051282051282051 remA; extracellular matrix regulatory protein A 74.0 75.0 0.0 1.0 1.0 S 0.0 75.0 1.0 1.0 COG2052 Regulator_of_extracellular_matrix_RemA,_YlzA/DUF370_family RemA 75.0 0.0 1.0 0.0207281359630275 0.0405487952056745 0.030638465584351 0.0198206592426469 0 0 0 0 K09778 0.0 0.2507122507122507 lpxJ; Kdo2-lipid IVA 3' secondary acyltransferase [EC:2.3.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 102.0 93.0 0.0 1.0 1.0 S 0.0 93.0 1.0 1.0 COG2121 Uncharacterized_conserved_protein,_lysophospholipid_acyltransferase_(LPLAT)_superfamily 93.0 0.0 1.0 0.0018650531402712 0.335755627709187 0.1688103404247291 0.3338905745689158 0 0 0 0 K09779 0.0771428571428571 0.1196581196581196 K09779; uncharacterized protein 51.0 74.0 0.0 1.0 1.0 S 29.0 45.0 1.0 1.0 COG2155 Uncharacterized_membrane_protein_YuzA,_DUF378_family YuzA 74.0 0.3918918918918919 0.6081081081081081 0.0201480938293783 0.0632188741414479 0.0416834839854131 0.0430707803120696 0 0 0 0 K09780 0.0114285714285714 0.2592592592592592 K09780; uncharacterized protein 57.0 106.0 101.0 2.0 0.954954954954955 S 6.0 105.0 2.0 0.972972972972973 COG2350 YciI_superfamily_enzyme,_includes_5-CHQ_dehydrochlorinase,_contains_active-site_pHis YciI 111.0 0.054054054054054 0.945945945945946 0.0062020641939499 0.0336106987462049 0.0199063814700773 0.027408634552255 0 0 0 0 K09781 0.0 0.1339031339031339 K09781; uncharacterized protein 246.0 48.0 0.0 1.0 1.0 S 0.0 48.0 1.0 1.0 COG2354 Membrane_protein_MutK/YedI,_may_be_involved_in_DNA_repair MutK 48.0 0.0 1.0 0.007208637389817 0.0126680741264731 0.009938355758145 0.0054594367366561 0 0 0 0 K09785 0.0 0.0256410256410256 K09785; uncharacterized protein 236.0 6.0 3.0 2.0 0.666666666666667 NU 0.0 9.0 1.0 1.0 COG2380 NurA-like_predicted_nuclease,_RNAse_H_fold NurA2 9.0 0.0 1.0 0.0982726971124966 0.657741995952469 0.3780073465324828 0.5594692988399723 0 0 0 0 K09786 0.1142857142857142 0.1623931623931624 K09786; uncharacterized protein 274.0 100.0 0.0 1.0 1.0 S 40.0 60.0 1.0 1.0 COG2718 Uncharacterized_conserved_protein_YeaH/YhbH,_required_for_sporulation,_DUF444_family YeaH 100.0 0.4 0.6 0.0099857660945272 0.166645595883635 0.0883156809890811 0.1566598297891078 0 0 0 0 K09787 0.0085714285714285 0.168091168091168 K09787; uncharacterized protein 71.0 59.0 0.0 1.0 1.0 S 3.0 59.0 2.0 0.951612903225806 COG2739 Predicted_DNA-binding_protein_YlxM,_UPF0122_family YlxM 62.0 0.0483870967741935 0.9516129032258064 0.005697277376927 0.0113883241736311 0.008542800775279 0.0056910467967041 0 0 0 0 K09788 0.0 0.0455840455840455 prpF; 2-methylaconitate isomerase [EC:5.3.3.-] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 386.0 16.0 15.0 2.0 0.941176470588235 S 0.0 17.0 1.0 1.0 COG2828 2-Methylaconitate_cis-trans-isomerase_PrpF_(2-methyl_citrate_pathway) PrpF 17.0 0.0 1.0 0.0103534905183221 0.0160346826919139 0.013194086605118 0.0056811921735917 0 0 0 0 K09789 0.0 0.0398860398860398 bioG; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 166.0 14.0 12.0 2.0 0.875 S 0.0 16.0 2.0 0.875 COG2830 Uncharacterized_conserved_protein,_DUF452_domain 16.0 0.0 1.0 0.0141716321391445 0.160319759889347 0.0872456960142457 0.1461481277502025 0 0 0 0 K09790 0.0685714285714285 0.2051282051282051 K09790; uncharacterized protein 103.0 92.0 87.0 2.0 0.948453608247423 S 24.0 73.0 2.0 0.989690721649485 COG2832 Uncharacterized_membrane_protein_YbaN,_DUF454_family YbaN 97.0 0.2474226804123711 0.7525773195876289 0.0542831469384208 0.101327434299037 0.0778052906187289 0.0470442873606162 0 0 0 0 K09791 0.08 0.4074074074074074 K09791; uncharacterized protein 33.0 139.0 112.0 3.0 0.803468208092485 S 28.0 145.0 2.0 0.994219653179191 COG2835 RNA_methyltransferase_activator_Trm112/YbaR Trm112 173.0 0.1618497109826589 0.838150289017341 0.0037661109610315 0.0337066775996132 0.0187363942803223 0.0299405666385816 0 0 0 0 K09792 0.0942857142857142 0.245014245014245 K09792; uncharacterized protein 138.0 114.0 96.0 3.0 0.826086956521739 S 49.0 89.0 2.0 0.992753623188406 COG2836 Uncharacterized_membrane_protein,_DsbD_domain DsbD 138.0 0.3550724637681159 0.644927536231884 0.0014619617584646 0.0416773427999524 0.0215696522792085 0.0402153810414878 0 0 0 0 K09793 0.1085714285714285 0.225071225071225 K09793; uncharacterized protein 129.0 120.0 0.0 1.0 1.0 S 38.0 82.0 2.0 0.683333333333333 COG2839 Uncharacterized_conserved_protein_YqgC,_DUF456_family YqgC 120.0 0.3166666666666666 0.6833333333333333 0.0070760402537167 0.070000435454112 0.0385382378539143 0.0629243952003952 0 0 0 0 K09794 0.0 0.1225071225071225 K09794; uncharacterized protein 59.0 40.0 0.0 1.0 1.0 S 0.0 44.0 8.0 0.613636363636364 COG2841 Uncharacterized_conserved_protein_YdcH,_DUF465_family YdcH 44.0 0.0 1.0 0.0041286673712768 0.0137579130560982 0.0089432902136875 0.0096292456848214 0 0 0 0 K09795 0.0 0.0427350427350427 K09795; uncharacterized protein 127.0 17.0 0.0 1.0 1.0 S 0.0 17.0 2.0 0.823529411764706 COG2845 Uncharacterized_conserved_protein,_DUF459_domain 17.0 0.0 1.0 0.0060308765806159 0.0132645879922883 0.0096477322864521 0.0072337114116724 0 0 0 0 K09796 0.0142857142857142 0.2051282051282051 pccA; periplasmic copper chaperone A 70.0 76.0 52.0 2.0 0.76 S 5.0 95.0 3.0 0.93 COG2847 Copper(I)-binding_protein 100.0 0.05 0.95 0.0061072156823005 0.0638627151888248 0.0349849654355626 0.0577554995065243 0 0 0 0 K09797 0.0 0.1082621082621082 K09797; uncharacterized protein 166.0 39.0 0.0 1.0 1.0 S 0.0 39.0 1.0 1.0 COG2859 Outer_membrane_channel-forming_protein_BP26/OMP28,_SIMPL_family SIMPL 39.0 0.0 1.0 0.0655226219054556 0.673150414453828 0.3693365181796417 0.6076277925483724 0 0 0 0 K09798 0.0 0.225071225071225 K09798; uncharacterized protein 128.0 76.0 66.0 2.0 0.883720930232558 S 0.0 86.0 2.0 0.988372093023256 COG2861 Uncharacterized_conserved_protein_YibQ,_putative_polysaccharide_deacetylase_2_family YibQ 86.0 0.0 1.0 0.0077679806167677 0.450783530054383 0.2292757553355753 0.4430155494376153 0 0 0 0 K09799 0.0428571428571428 0.0541310541310541 K09799; uncharacterized protein 283.0 34.0 0.0 1.0 1.0 S 15.0 19.0 1.0 1.0 COG2899 Uncharacterized_TerC-related_membrane_protein,_DUF475_domain TerC2 34.0 0.4411764705882353 0.5588235294117647 0.0083235189907281 0.0600558904227056 0.0341897047067168 0.0517323714319775 0 0 0 0 K09800 0.0 0.3846153846153846 tamB; translocation and assembly module TamB 12.0 133.0 98.0 5.0 0.734806629834254 S 0.0 175.0 4.0 0.922651933701657 COG2911 Autotransporter_translocation_and_assembly_protein_TamB TamB 175.0 0.0 1.0 0.0510024000895331 0.0996433585144787 0.0753228793020059 0.0486409584249456 0 0 0 0 K09801 0.0 0.0826210826210826 K09801; uncharacterized protein 85.0 30.0 0.0 1.0 1.0 S 0.0 30.0 1.0 1.0 COG2914 Putative_antitoxin_component_PasI_(RatB)_of_the_RatAB_toxin-antitoxin_module,_ubiquitin-RnfH_superfamily PasI 30.0 0.0 1.0 0.0033587758536017 0.0078920982976556 0.0056254370756286 0.0045333224440539 0 0 0 0 K09802 0.0 0.017094017094017 K09802; uncharacterized protein 98.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG2926 Uncharacterized_conserved_protein_YeeX,_DUF496_family YeeX 6.0 0.0 1.0 1.58132343703347e-12 3.2833267619676996e-12 2.432325099500585e-12 1.7020033249342302e-12 0 0 0 0 K09803 0.0085714285714285 0.1766381766381766 K09803; uncharacterized protein 44.0 148.0 0.0 1.0 1.0 S 3.0 145.0 1.0 1.0 COG2929 Uncharacterized_conserved_protein,_DUF497_family 148.0 0.0202702702702702 0.9797297297297296 0.014827055931849 0.193455625979852 0.1041413409558505 0.178628570048003 0 0 0 0 K09804 0.0 0.0541310541310541 K09804; uncharacterized protein 79.0 21.0 0.0 1.0 1.0 S 0.0 21.0 1.0 1.0 COG2952 Uncharacterized_conserved_protein,_DUF507_domain 21.0 0.0 1.0 0.0036264349584694 0.0035682752501383 0.0035973551043038 5.815970833110027e-05 0 0 0 0 K09805 0.0 0.0 K09805; uncharacterized protein 4.0 2.0 2.0 0.666666666666667 S 0.0 0.0 1.0 1.0 COG2958 Uncharacterized_conserved_protein 0.0 0 0 0 0 K09806 0.0 0.1481481481481481 ubiK; ubiquinone biosynthesis accessory factor UbiK 73.0 51.0 50.0 2.0 0.980769230769231 S 0.0 52.0 1.0 1.0 COG2960 Ubiquinone_biosynthesis_accessory_factor_UbiK UbiK 52.0 0.0 1.0 0.0013940273631181 0.0026518863256153 0.0020229568443667 0.0012578589624972 0 0 0 0 K09807 0.2914285714285714 0.3618233618233618 K09807; uncharacterized protein 84.0 253.0 0.0 1.0 1.0 S 115.0 138.0 2.0 0.992094861660079 COG2968 Uncharacterized_conserved_protein_YggE,_contains_kinase-interacting_SIMPL_domain YggE 253.0 0.4545454545454545 0.5454545454545454 0.0661114825471523 0.234658353503529 0.1503849180253406 0.1685468709563767 0 0 0 0 K09808 0.0657142857142857 0.5584045584045584 lolC_E; lipoprotein-releasing system permease protein path:map02010 ABC transporters 138.0 321.0 305.0 3.0 0.944117647058824 M 44.0 296.0 2.0 0.991176470588235 COG4591 ABC-type_transport_system_involved_in_lipoprotein_release,_permease_component_LolC LolE 340.0 0.1294117647058823 0.8705882352941177 0.0034158813706683 0.246361562882305 0.1248887221264866 0.2429456815116367 0 0 0 0 K09809 0.0514285714285714 0.1025641025641025 tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12] path:map00552 Teichoic acid biosynthesis 43.0 82.0 74.0 4.0 0.872340425531915 M 27.0 51.0 9.0 0.340425531914894 COG1887 CDP-glycerol_glycerophosphotransferase,_TagB/SpsB_family TagB 78.0 0.3461538461538461 0.6538461538461539 0.065747226499889 0.13441745103607 0.1000823387679795 0.068670224536181 0 0 0 0 K09810 0.1114285714285714 0.5897435897435898 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-] path:map02010 ABC transporters 132.0 265.0 242.0 4.0 0.841269841269841 V 50.0 265.0 3.0 0.971428571428571 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 315.0 0.1587301587301587 0.8412698412698413 0.0030120796792407 0.0142570811470463 0.0086345804131435 0.0112450014678056 0 0 0 0 K09811 0.0 0.717948717948718 ftsX; cell division transport system permease protein path:map02010 ABC transporters 88.0 267.0 0.0 1.0 1.0 D 0.0 268.0 3.0 0.966417910447761 COG2177 Cell_division_protein_FtsX FtsX 268.0 0.0 1.0 0.0143343365583476 0.671395111231556 0.3428647238949518 0.6570607746732084 0 0 0 0 K09812 0.0 0.7407407407407407 ftsE; cell division transport system ATP-binding protein path:map02010 ABC transporters 109.0 280.0 275.0 2.0 0.982456140350877 D 0.0 285.0 3.0 0.901754385964912 COG2884 Cell_division_ATPase_FtsE FtsE 285.0 0.0 1.0 0.0241277521279111 0.679624715183428 0.3518762336556695 0.655496963055517 0 0 0 0 K09813 0.0 0.0028490028490028 hrtB; hemin transport system permease protein path:map02010 ABC transporters 350.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 1.0 0.0 1.0 0 0 0 0 K09814 0.0 0.0256410256410256 hrtA; hemin transport system ATP-binding protein [EC:7.6.2.-] path:map02010 ABC transporters 95.0 8.0 7.0 2.0 0.888888888888889 V 0.0 9.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 9.0 0.0 1.0 0.0466661171478153 0.135690273581832 0.0911781953648236 0.0890241564340167 0 0 0 0 K09815 0.3028571428571429 0.6125356125356125 znuA; zinc transport system substrate-binding protein path:map02010 ABC transporters 20.0 383.0 354.0 4.0 0.909738717339668 P 148.0 273.0 4.0 0.840855106888361 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 421.0 0.3515439429928741 0.6484560570071259 0.0160284033504327 0.0102605162209244 0.0131444597856785 0.0057678871295083 0 0 0 0 K09816 0.3942857142857143 0.5698005698005698 znuB; zinc transport system permease protein path:map02010 ABC transporters 180.0 393.0 379.0 2.0 0.965601965601966 P 183.0 224.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 407.0 0.4496314496314496 0.5503685503685504 0.658338221613611 0.975401050961646 0.8168696362876284 0.317062829348035 0 1 0 1 K09817 0.3857142857142857 0.5413105413105413 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] path:map02010 ABC transporters 113.0 250.0 123.0 4.0 0.649350649350649 P 171.0 214.0 4.0 0.976623376623377 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 385.0 0.4441558441558441 0.5558441558441558 0.0972272401601184 0.199355261072608 0.1482912506163632 0.1021280209124896 0 0 0 0 K09818 0.04 0.1766381766381766 ABC.MN.S; manganese/iron transport system substrate-binding protein 190.0 91.0 88.0 2.0 0.968085106382979 P 15.0 79.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 94.0 0.1595744680851064 0.8404255319148937 0.0439080909187886 0.860191033228846 0.4520495620738173 0.8162829423100575 0 0 0 0 K09819 0.0657142857142857 0.2279202279202279 ABC.MN.P; manganese/iron transport system permease protein 214.0 123.0 115.0 3.0 0.931818181818182 P 26.0 106.0 2.0 0.96969696969697 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 132.0 0.1969696969696969 0.803030303030303 0.0539298005671173 0.887658107021926 0.4707939537945216 0.8337283064548088 0 0 0 0 K09820 0.0171428571428571 0.2165242165242165 ABC.MN.A; manganese/iron transport system ATP-binding protein 187.0 88.0 78.0 2.0 0.897959183673469 P 6.0 92.0 2.0 0.887755102040816 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 98.0 0.0612244897959183 0.9387755102040816 0.0427088572845948 0.0808566428438605 0.0617827500642276 0.0381477855592657 0 0 0 0 K09822 0.0657142857142857 0.094017094017094 K09822; uncharacterized protein 549.0 60.0 56.0 4.0 0.882352941176471 S 24.0 44.0 2.0 0.970588235294118 COG3002 Na+-translocating_membrane_potential-generating_system_subunit_MpsB,_UPF0753/DUF2309_family MpsB 68.0 0.3529411764705882 0.6470588235294118 0.0064408343636172 0.0107228664428244 0.0085818504032207 0.0042820320792072 0 0 0 0 K09823 0.0 0.1794871794871795 zur; Fur family transcriptional regulator, zinc uptake regulator path:map02024 Quorum sensing 83.0 58.0 47.0 2.0 0.840579710144927 P 0.0 69.0 1.0 1.0 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 69.0 0.0 1.0 0.021928639591057 0.041951827664642 0.0319402336278495 0.0200231880735849 0 0 0 0 K09824 0.0 0.0313390313390313 virK; uncharacterized protein 252.0 10.0 9.0 2.0 0.909090909090909 S 0.0 11.0 2.0 0.909090909090909 COG2990 Outer_membrane_protein_VirK/YbjX_involved_in_antimicrobial_peptide_resistance,_DUF535_family VirK 11.0 0.0 1.0 0.0272728930726654 0.0813556145734855 0.0543142538230754 0.0540827215008201 0 0 0 0 K09825 0.1885714285714285 0.4615384615384615 perR; Fur family transcriptional regulator, peroxide stress response regulator 59.0 198.0 133.0 3.0 0.744360902255639 P 72.0 194.0 1.0 1.0 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 266.0 0.2706766917293233 0.7293233082706767 0.964317184093918 0.954206691596836 0.959261937845377 0.0101104924970819 1 1 1 1 K09826 0.0 0.0883190883190883 irr; Fur family transcriptional regulator, iron response regulator 107.0 28.0 19.0 2.0 0.756756756756757 K 0.0 37.0 1.0 1.0 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 37.0 0.0 1.0 0.0024277924280281 0.0050124205302471 0.0037201064791376 0.0025846281022189 0 0 0 0 K09828 0.0028571428571428 0.0085470085470085 DHCR24, DWF1; Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 96.0 4.0 0.0 1.0 1.0 C 1.0 3.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 4.0 0.25 0.75 0.149904923293981 0.211511887000044 0.1807084051470125 0.061606963706063 0 0 0 0 K09833 0.0057142857142857 0.0341880341880341 HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase [EC:2.5.1.115 2.5.1.116] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 286.0 14.0 0.0 1.0 1.0 H 2.0 12.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 14.0 0.1428571428571428 0.8571428571428571 0.0181150057530223 7.58899377304532e-07 0.0090578823261998 0.0181142468536449 0 0 0 0 K09834 0.0 0.0398860398860398 VTE1, SXD1; tocopherol cyclase [EC:5.5.1.24] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 315.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 arCOG12964 14.0 0.0 1.0 0.005962673172762 0.0049594838819106 0.0054610785273363 0.0010031892908514 0 0 0 0 K09835 0.0257142857142857 0.1111111111111111 crtISO, crtH; prolycopene isomerase [EC:5.2.1.13] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 195.0 77.0 75.0 2.0 0.974683544303797 Q 24.0 55.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 79.0 0.3037974683544304 0.6962025316455697 0.0044648677068318 0.0136558692623546 0.0090603684845932 0.0091910015555227 0 0 0 0 K09836 0.0 0.0199430199430199 crtW, BKT; beta-carotene/zeaxanthin 4-ketolase [EC:1.14.99.63 1.14.99.64] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 229.0 8.0 0.0 1.0 1.0 I 0.0 8.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 8.0 0.0 1.0 0.0121516606922786 0.057159576552204 0.0346556186222413 0.0450079158599254 0 0 0 0 K09844 0.0057142857142857 0.0427350427350427 crtC; carotenoid 1,2-hydratase [EC:4.2.1.131] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 215.0 12.0 9.0 3.0 0.75 S 2.0 15.0 2.0 0.764705882352941 COG5621 Predicted_lipocalin,_contains_AttH/CrtC_domain CrtC 17.0 0.1176470588235294 0.8823529411764706 0.0662180183969113 0.142886346986709 0.1045521826918101 0.0766683285897976 0 0 0 0 K09845 0.0 0.0313390313390313 crtD; 1-hydroxycarotenoid 3,4-desaturase [EC:1.3.99.27] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 483.0 8.0 5.0 2.0 0.727272727272727 Q 0.0 11.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 11.0 0.0 1.0 0.0101546814000895 0.0218040772263431 0.0159793793132163 0.0116493958262535 0 0 0 0 K09846 0.0085714285714285 0.0569800569800569 crtF; demethylspheroidene O-methyltransferase [EC:2.1.1.210] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 266.0 15.0 11.0 5.0 0.652173913043478 Q 3.0 20.0 3.0 0.695652173913044 COG0500 SAM-dependent_methyltransferase SmtA 23.0 0.1304347826086956 0.8695652173913043 0.0153706111718637 0.0253152631645623 0.0203429371682129 0.0099446519926986 0 0 0 0 K09847 0.0 0.0113960113960113 crtA; spheroidene monooxygenase [EC:1.14.15.9] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 210.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 29UQ5 4.0 0.0 1.0 9.83275152965114e-12 1.57637782202132e-08 7.886805485871427e-09 1.5753945468683548e-08 0 0 0 0 K09857 0.0 0.1054131054131054 K09857; uncharacterized protein 97.0 32.0 26.0 3.0 0.82051282051282 S 0.0 39.0 2.0 0.948717948717949 COG3009 Intermembrane_transporter_PqiABC_lipoprotein_subunit_PqiC PqiC 39.0 0.0 1.0 0.0034894810287559 0.0078528306344159 0.0056711558315859 0.00436334960566 0 0 0 0 K09858 0.0 0.2136752136752136 K09858; SEC-C motif domain protein 76.0 69.0 66.0 2.0 0.958333333333333 S 0.0 78.0 1.0 1.0 COG3012 Uncharacterized_conserved_protein_YchJ,_contains_N-_and_C-terminal_SEC-C_domains YchJ 78.0 0.0 1.0 0.0062139876207512 0.0222969167710834 0.0142554521959173 0.0160829291503321 0 0 0 0 K09859 0.0 0.1025641025641025 K09859; uncharacterized protein 199.0 36.0 35.0 2.0 0.972972972972973 S 0.0 37.0 3.0 0.810810810810811 COG3014 Uncharacterized_conserved_protein 37.0 0.0 1.0 0.0061429591827363 0.0488167598741895 0.0274798595284629 0.0426738006914532 0 0 0 0 K09860 0.0 0.0598290598290598 flgP; outer membrane protein FlgP path:map02040 Flagellar assembly 93.0 15.0 0.0 1.0 1.0 S 0.0 21.0 1.0 1.0 COG3018 Flagellar_basal_body_lipoprotein_FlgP,_LPP20_family FlgP 21.0 0.0 1.0 0.0208816886845117 0.111154530366442 0.0660181095254768 0.0902728416819303 0 0 0 0 K09861 0.0114285714285714 0.2934472934472934 K09861; uncharacterized protein 130.0 108.0 0.0 1.0 1.0 S 4.0 104.0 1.0 1.0 COG3022 DNA-binding_protein_YaaA_associated_with_the_oxidative_stress_response YaaA 108.0 0.037037037037037 0.9629629629629628 0.0029401669571859 0.0107020507537264 0.0068211088554561 0.0077618837965405 0 0 0 0 K09862 0.0 0.188034188034188 K09862; uncharacterized protein 34.0 67.0 0.0 1.0 1.0 S 0.0 67.0 1.0 1.0 COG3024 Endogenous_inhibitor_of_DNA_gyrase,_YacG/DUF329_family YacG 67.0 0.0 1.0 0.0030280878318286 0.0089715280391271 0.0059998079354778 0.0059434402072985 0 0 0 0 K09866 0.0285714285714285 0.0 AQP4; aquaporin-4 path:map04962,path:map04976 Vasopressin-regulated water reabsorption,Bile secretion 234.0 10.0 0.0 1.0 1.0 G 10.0 0.0 1.0 1.0 COG0580 Glycerol_uptake_facilitator_or_related_aquaporin_(Major_Intrinsic_protein_Family) GlpF 10.0 1.0 0.0 0.0071587952436939 0.0131143132080509 0.0101365542258724 0.005955517964357 0 0 0 0 K09874 0.0057142857142857 0.017094017094017 NIP; aquaporin NIP 218.0 6.0 4.0 2.0 0.75 U 2.0 6.0 1.0 1.0 COG0580 Glycerol_uptake_facilitator_or_related_aquaporin_(Major_Intrinsic_protein_Family) GlpF 8.0 0.25 0.75 0.16644926626671 0.795205850996918 0.480827558631814 0.628756584730208 0 0 0 0 K09879 0.0 0.0626780626780626 crtU, cruE; carotenoid phi-ring synthase / carotenoid chi-ring synthase [EC:1.3.99.39 1.3.99.40] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 425.0 8.0 3.0 6.0 0.347826086956522 H 0.0 23.0 5.0 0.347826086956522 COG0723 Rieske_Fe-S_protein QcrA/PetC 23.0 0.0 1.0 0.0337227928929383 0.169319576940745 0.1015211849168416 0.1355967840478067 0 0 0 0 K09880 0.0085714285714285 0.0712250712250712 mtnC, ENOPH1; enolase-phosphatase E1 [EC:3.1.3.77] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 198.0 17.0 8.0 4.0 0.586206896551724 E 3.0 26.0 1.0 1.0 COG4229 Enolase-phosphatase_E1_involved_in_merthionine_salvage Utr4 29.0 0.1034482758620689 0.896551724137931 0.0208889217165605 0.0475755984181241 0.0342322600673423 0.0266866767015636 0 0 0 0 K09882 0.0028571428571428 0.1339031339031339 cobS; cobaltochelatase CobS [EC:6.6.1.2] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 267.0 47.0 43.0 2.0 0.92156862745098 S 1.0 50.0 1.0 1.0 COG0714 MoxR-like_ATPase MoxR 51.0 0.0196078431372549 0.9803921568627452 0.0029456960992883 0.0084218614814992 0.0056837787903937 0.0054761653822109 0 0 0 0 K09883 0.0 0.1025641025641025 cobT; cobaltochelatase CobT [EC:6.6.1.2] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 501.0 36.0 0.0 1.0 1.0 H 0.0 36.0 1.0 1.0 COG4547 Cobalamin_biosynthesis_cobaltochelatase_CobT_subunit CobT2 36.0 0.0 1.0 0.0040204518906863 0.0048334150717311 0.0044269334812087 0.0008129631810447 0 0 0 0 K09884 0.0028571428571428 0.0028490028490028 AQPN; aquaporin rerated protein, invertebrate 55.0 2.0 0.0 1.0 1.0 G 1.0 1.0 1.0 1.0 COG0580 Glycerol_uptake_facilitator_or_related_aquaporin_(Major_Intrinsic_protein_Family) GlpF 2.0 0.5 0.5 0 0 0 0 K09887 0.0628571428571428 0.0 dcd; dCTP deaminase (dUMP-forming) [EC:3.5.4.30] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 141.0 22.0 0.0 1.0 1.0 F 22.0 0.0 1.0 1.0 COG0717 dCTP_deaminase Dcd 22.0 1.0 0.0 0.0463494886013532 0.0107442199909665 0.0285468542961598 0.0356052686103866 0 0 0 0 K09888 0.0 0.4643874643874643 zapA; cell division protein ZapA 42.0 161.0 158.0 2.0 0.981707317073171 D 0.0 164.0 5.0 0.945121951219512 COG3027 Cell_division_protein_ZapA,_inhibits_GTPase_activity_of_FtsZ ZapA 164.0 0.0 1.0 0.0033464331996226 0.0836179377812388 0.0434821854904307 0.0802715045816162 0 0 0 0 K09889 0.0 0.0911680911680911 yjgA; ribosome-associated protein 128.0 33.0 0.0 1.0 1.0 S 0.0 33.0 1.0 1.0 COG3028 Ribosomal_50S_subunit-associated_protein_YjgA,_DUF615_family YjgA 33.0 0.0 1.0 0.0029356878239001 0.0062772914818155 0.0046064896528578 0.0033416036579154 0 0 0 0 K09890 0.0 0.017094017094017 arfA; alternative ribosome-rescue factor 62.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG3036 Stalled_ribosome_alternative_rescue_factor_ArfA ArfA 6.0 0.0 1.0 1.31728319329354e-12 2.57080745319478e-08 1.2854695907570546e-08 2.5706757248754507e-08 0 0 0 0 K09891 0.0 0.0313390313390313 K09891; uncharacterized protein 189.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG3068 Uncharacterized_conserved_protein_YjaG,_DUF416_family YjaG 11.0 0.0 1.0 0.0010459113596624 0.0017632463507681 0.0014045788552152 0.0007173349911056 0 0 0 0 K09892 0.0 0.0484330484330484 zapB; cell division protein ZapB 48.0 12.0 8.0 2.0 0.75 D 0.0 18.0 5.0 0.388888888888889 COG3074 Cell_division_protein_ZapB,_interacts_with_FtsZ ZapB 18.0 0.0 1.0 0.021176293812553 0.0352102769896212 0.0281932854010871 0.0140339831770682 0 0 0 0 K09893 0.0 0.0227920227920227 rraB; regulator of ribonuclease activity B 121.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG3076 Regulator_of_RNase_E_activity_RraB RraB 8.0 0.0 1.0 9.78894732292158e-13 2.03806387511312e-12 1.508479303702639e-12 1.059169142820962e-12 0 0 0 0 K09894 0.0 0.0199430199430199 K09894; uncharacterized protein 155.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3078 Ribosome_assembly_protein_YihI,_activator_of_Der_GTPase YihI 7.0 0.0 1.0 1.23356849520586e-21 5.92291182540286e-17 2.961517591126191e-17 5.92278846855334e-17 0 0 0 0 K09895 0.0 0.0512820512820512 K09895; uncharacterized protein 147.0 18.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG3079 Uncharacterized_conserved_protein_YgfB,_UPF0149_family YgfB 18.0 0.0 1.0 0.0017180338865627 0.0025051228278892 0.0021115783572259 0.0007870889413265 0 0 0 0 K09896 0.0 0.0142450142450142 K09896; uncharacterized protein 89.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3084 Uncharacterized_conserved_protein_YihD,_DUF1040_family YihD 5.0 0.0 1.0 1.2335676239122e-21 1.69962838753869e-17 8.498758721505407e-18 1.6995050307762988e-17 0 0 0 0 K09897 0.0 0.0227920227920227 K09897; uncharacterized protein 100.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 COG3085 Uncharacterized_conserved_protein_YifE,_UPF0438_family YifE 10.0 0.0 1.0 7.54856795841402e-07 8.65378409572487e-12 3.774327248127489e-07 7.548481420573063e-07 0 0 0 0 K09898 0.0 0.0484330484330484 K09898; uncharacterized protein 72.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG3089 Uncharacterized_conserved_protein_YheU,_UPF0270_family YheU 17.0 0.0 1.0 0.0054825996440835 0.0111986543840413 0.0083406270140624 0.0057160547399577 0 0 0 0 K09899 0.0 0.0227920227920227 K09899; uncharacterized protein 141.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG3092 Uncharacterized_membrane_protein_YfbV,_UPF0208_family YfbV 8.0 0.0 1.0 1.2335450450503201e-21 2.54742479507836e-13 1.2737124037069053e-13 2.5474247827429095e-13 0 0 0 0 K09900 0.0 0.0085470085470085 E3.5.1.135; N4-acetylcytidine amidohydrolase [EC:3.5.1.135] 101.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3097 Uncharacterized_conserved_protein_YqfB,_UPF0267_family YqfB 3.0 0.0 1.0 0 0 0 0 K09901 0.0 0.017094017094017 K09901; uncharacterized protein 97.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG3099 Uncharacterized_conserved_protein_YciU,_UPF0263_family YciU 6.0 0.0 1.0 1.37617624630373e-12 1.86799599995883e-08 9.3406680879173e-09 1.8678583823342e-08 0 0 0 0 K09902 0.0 0.0455840455840455 K09902; uncharacterized protein 79.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 COG3100 Uncharacterized_conserved_protein_YcgL,_UPF0745_family YcgL 16.0 0.0 1.0 0.0025818291707185 0.0032016978150409 0.0028917634928797 0.0006198686443224 0 0 0 0 K09903 0.8342857142857143 0.9487179487179488 pyrH; uridylate kinase [EC:2.7.4.22] path:map00240,path:map01100,path:map01232,path:map01240 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism,Biosynthesis of cofactors 109.0 632.0 0.0 1.0 1.0 F 294.0 338.0 1.0 1.0 COG0528 Uridylate_kinase PyrH 632.0 0.4651898734177215 0.5348101265822784 0.583719335764614 0.469418120460841 0.5265687281127275 0.1143012153037729 0 1 0 1 K09904 0.0 0.0199430199430199 K09904; uncharacterized protein 73.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3082 Uncharacterized_conserved_protein_YejL,_UPF0352_family YejL 7.0 0.0 1.0 6.20972385884922e-05 0.0001880244278902 0.0001250608332393 0.0001259271893017 0 0 0 0 K09906 0.0 0.037037037037037 epmC; elongation factor P hydroxylase [EC:1.14.-.-] 168.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3101 Elongation_factor_P_hydroxylase_EpmC_(EF-P_beta-lysylation_pathway) EpmC 13.0 0.0 1.0 0.0053241202379999 0.0101296236682178 0.0077268719531088 0.0048055034302178 0 0 0 0 K09907 0.0 0.0256410256410256 K09907; uncharacterized protein 152.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 COG3102 Uncharacterized_conserved_protein_YecM,_predicted_metalloenzyme YecM 9.0 0.0 1.0 0.0047593032726722 0.0084868638628684 0.0066230835677703 0.0037275605901962 0 0 0 0 K09908 0.0 0.037037037037037 K09908; uncharacterized protein 113.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3105 Uncharacterized_membrane-anchored_protein_YhcB,_DUF1043_family YhcB 13.0 0.0 1.0 0.0010692550961062 3.84704630589212e-08 0.0005346467832846 0.0010692166256431 0 0 0 0 K09909 0.0 0.0199430199430199 K09909; uncharacterized protein 174.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG3110 Uncharacterized_conserved_protein_YccT,_UPF0319_family YccT 8.0 0.0 1.0 1.35047333059762e-06 2.7258905300019e-05 1.430468931530831e-05 2.590843196942138e-05 0 0 0 0 K09910 0.0 0.0199430199430199 K09910; uncharacterized protein 119.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3112 Uncharacterized_conserved_protein_YacL,_UPF0231_family YacL 7.0 0.0 1.0 0.0012951154212124 6.43594531920606e-10 0.0006475580324034 0.0012951147776178 0 0 0 0 K09911 0.0 0.0142450142450142 K09911; uncharacterized protein 148.0 5.0 0.0 1.0 1.0 D 0.0 5.0 1.0 1.0 COG3120 Macrodomain_Ter_protein_organizer,_MatP/YcbG_family MatP 5.0 0.0 1.0 3.54962710421091e-21 3.38358670817022e-17 1.691970835440321e-17 3.383231745459799e-17 0 0 0 0 K09912 0.0 0.0455840455840455 K09912; uncharacterized protein 169.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 COG3122 Uncharacterized_conserved_protein_YaiL,_DUF2058_family YaiL 16.0 0.0 1.0 0.004961413779917 0.0072576235351451 0.006109518657531 0.002296209755228 0 0 0 0 K09913 0.0 0.0997150997150997 ppnP; purine/pyrimidine-nucleoside phosphorylase [EC:2.4.2.1 2.4.2.2] path:map00230,path:map00240,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 92.0 34.0 33.0 2.0 0.971428571428571 S 0.0 35.0 1.0 1.0 COG3123 Pyrimidine/purine_nucleoside_phosphorylase_YaiE/PpnP,_UPF0345/DUF1255_family PpnP 35.0 0.0 1.0 0.008655500934011 0.0285683568045968 0.0186119288693039 0.0199128558705857 0 0 0 0 K09914 0.0028571428571428 0.094017094017094 K09914; putative lipoprotein 17.0 22.0 11.0 4.0 0.628571428571429 O 1.0 36.0 7.0 0.45945945945946 COG3126 Uncharacterized_lipoprotein_YbaY YbaY 37.0 0.027027027027027 0.972972972972973 0.0489189540326877 0.485582895157205 0.2672509245949463 0.4366639411245173 0 0 0 0 K09915 0.0 0.0769230769230769 K09915; uncharacterized protein 163.0 25.0 23.0 2.0 0.925925925925926 S 0.0 27.0 2.0 0.925925925925926 COG3132 Uncharacterized_conserved_protein_YceH,_UPF0502_family YceH 27.0 0.0 1.0 0.0059794015452467 0.0281233953899265 0.0170513984675866 0.0221439938446798 0 0 0 0 K09916 0.0 0.0313390313390313 K09916; uncharacterized protein 80.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG3139 Uncharacterized_conserved_protein_YeaC,_DUF1315_family yeaC 11.0 0.0 1.0 1.14441324447914e-12 2.40628661195611e-12 1.775349928217625e-12 1.2618733674769701e-12 0 0 0 0 K09917 0.0 0.0142450142450142 K09917; uncharacterized protein 51.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3140 Uncharacterized_conserved_protein_YoaH,_UPF0181_family yoaH 5.0 0.0 1.0 1.23359229523974e-21 1.6995434071922902e-17 8.49833383210907e-18 1.6994200479627666e-17 0 0 0 0 K09918 0.0 0.0341880341880341 K09918; uncharacterized protein 95.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG3141 dsDNA-binding_SOS-regulon_protein_YebG,_induction_by_DNA_damage_requires_cAMP YebG 15.0 0.0 1.0 0.0051682202689567 0.0117939610197525 0.0084810906443546 0.0066257407507958 0 0 0 0 K09919 0.0028571428571428 0.1937321937321937 K09919; uncharacterized protein 279.0 72.0 68.0 2.0 0.947368421052632 S 2.0 74.0 2.0 0.973684210526316 COG3146 Predicted_N-acyltransferase 76.0 0.0263157894736842 0.9736842105263158 0.0022188732178323 0.0349862231871403 0.0186025482024863 0.032767349969308 0 0 0 0 K09920 0.0 0.037037037037037 K09920; uncharacterized protein 113.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3151 Uncharacterized_conserved_protein_YqiB,_DUF1249_family yqiB 13.0 0.0 1.0 2.6548974790415e-12 2.74029575188518e-08 1.370280620816542e-08 2.740030262137276e-08 0 0 0 0 K09921 0.0 0.1225071225071225 K09921; uncharacterized protein 124.0 40.0 38.0 3.0 0.930232558139535 S 0.0 43.0 2.0 0.976744186046512 COG3159 Uncharacterized_conserved_protein_YigA,_DUF484_family YigA 43.0 0.0 1.0 0.0015746524916904 0.0041327414060223 0.0028536969488563 0.0025580889143318 0 0 0 0 K09922 0.0 0.1225071225071225 K09922; uncharacterized protein 103.0 45.0 0.0 1.0 1.0 S 0.0 45.0 1.0 1.0 COG3169 Uncharacterized_membrane_protein,_DMT/DUF486_family 45.0 0.0 1.0 0.0070984826314178 0.0167027648447947 0.0119006237381062 0.0096042822133769 0 0 0 0 K09923 0.0 0.0256410256410256 K09923; uncharacterized protein 103.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 COG3171 Uncharacterized_conserved_protein_YggL,_DUF469_family YggL 10.0 0.0 1.0 3.01878197916196e-05 4.64251778670768e-05 3.83064988293482e-05 1.6237358075457198e-05 0 0 0 0 K09924 0.0 0.074074074074074 K09924; uncharacterized protein 63.0 28.0 0.0 1.0 1.0 S 0.0 29.0 3.0 0.931034482758621 COG3184 Uncharacterized_conserved_protein,_contains_DUF2059_domain 29.0 0.0 1.0 0.0131246286151405 0.0342224802089304 0.0236735544120354 0.0210978515937899 0 0 0 0 K09925 0.0 0.0142450142450142 K09925; uncharacterized protein 170.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3196 Colicin_E2_tolerance_protein_CbrC,_UPF0167_family CbrC 5.0 0.0 1.0 0.0551440797644532 0.1246279299357 0.0898860048500766 0.0694838501712468 0 0 0 0 K09926 0.0 0.0569800569800569 K09926; uncharacterized protein 117.0 20.0 0.0 1.0 1.0 S 0.0 20.0 1.0 1.0 COG3198 Uncharacterized_conserved_protein 20.0 0.0 1.0 0.003513593589444 0.0074143975193244 0.0054639955543842 0.0039008039298804 0 0 0 0 K09927 0.0257142857142857 0.1623931623931624 K09927; uncharacterized protein 227.0 65.0 59.0 2.0 0.915492957746479 S 12.0 59.0 1.0 1.0 COG3214 DNA_glycosylase_YcaQ,_repair_of_DNA_interstrand_crosslinks YcaQ 71.0 0.1690140845070422 0.8309859154929577 0.381072600208109 0.929444366854343 0.655258483531226 0.548371766646234 0 0 0 0 K09928 0.0742857142857142 0.245014245014245 K09928; uncharacterized protein 78.0 103.0 88.0 2.0 0.872881355932203 S 28.0 90.0 3.0 0.771186440677966 COG3216 Uncharacterized_conserved_protein,_DUF2062_family 118.0 0.2372881355932203 0.7627118644067796 0.108496246317358 0.053913852389355 0.0812050493533565 0.054582393928003 0 0 0 0 K09929 0.0 0.0284900284900284 K09929; uncharacterized protein 223.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG3219 Uncharacterized_conserved_protein,_DUF2063_family 11.0 0.0 1.0 0.0072077258745058 0.0295706169407059 0.0183891714076058 0.0223628910662001 0 0 0 0 K09930 0.0 0.1396011396011396 K09930; uncharacterized protein 191.0 56.0 53.0 2.0 0.949152542372881 S 0.0 59.0 1.0 1.0 COG3220 Uncharacterized_conserved_protein,_UPF0276_family 59.0 0.0 1.0 0.0051143510281049 0.0210013657854227 0.0130578584067638 0.0158870147573178 0 0 0 0 K09931 0.0371428571428571 0.2393162393162393 K09931; uncharacterized protein 84.0 96.0 92.0 5.0 0.905660377358491 S 15.0 93.0 4.0 0.844036697247707 COG3222 Uncharacterized_conserved_protein,_glycosyltransferase_A_(GT-A)_superfamily,_DUF2064_family 108.0 0.1388888888888889 0.8611111111111112 0.0134229186440294 0.162514100338432 0.0879685094912307 0.1490911816944026 0 0 0 0 K09932 0.0171428571428571 0.0626780626780626 K09932; uncharacterized protein 138.0 24.0 0.0 1.0 1.0 S 7.0 25.0 1.0 1.0 COG3224 Antibiotic_biosynthesis_monooxygenase_(ABM)_superfamily_enzyme 32.0 0.21875 0.78125 0.0450581800737933 0.237876385494573 0.1414672827841831 0.1928182054207796 0 0 0 0 K09933 0.0057142857142857 0.1168091168091168 mtfA; MtfA peptidase 130.0 48.0 47.0 3.0 0.96 S 2.0 50.0 2.0 0.923076923076923 COG3228 Mlc_titration_factor_MtfA,_regulates_ptsG_expression MtfA 52.0 0.0384615384615384 0.9615384615384616 0.0733215433492998 0.047832175098923 0.0605768592241114 0.0254893682503768 0 0 0 0 K09934 0.0028571428571428 0.017094017094017 K09934; uncharacterized protein 155.0 7.0 6.0 2.0 0.875 S 1.0 7.0 2.0 0.75 COG3234 Uncharacterized_conserved_protein_YfaT,_DUF1175_family yfaT 8.0 0.125 0.875 0.0871554378592214 0.102180932995766 0.0946681854274937 0.0150254951365445 0 0 0 0 K09935 0.0057142857142857 0.1168091168091168 ybiA; N-glycosidase YbiA [EC:3.2.2.-] 128.0 49.0 0.0 1.0 1.0 O 2.0 47.0 2.0 0.979591836734694 COG5113 49.0 0.0408163265306122 0.9591836734693876 0.0144337364483879 0.0850831788848273 0.0497584576666076 0.0706494424364394 0 0 0 0 K09936 0.0028571428571428 0.188034188034188 TC.BAT2; bacterial/archaeal transporter family-2 protein path:map02024 Quorum sensing 99.0 83.0 80.0 2.0 0.965116279069768 S 1.0 85.0 3.0 0.953488372093023 COG3238 Uncharacterized_membrane_protein_YdcZ,_DUF606_family ydcZ 86.0 0.0116279069767441 0.9883720930232558 0.0027006964541742 0.0043403596468347 0.0035205280505044 0.0016396631926605 0 0 0 0 K09937 0.0 0.1282051282051282 K09937; uncharacterized protein 57.0 45.0 0.0 1.0 1.0 S 0.0 45.0 1.0 1.0 COG3242 Uncharacterized_conserved_protein_YjeT,_DUF2065_family yjeT 45.0 0.0 1.0 0.0042001013097405 0.008727326586887 0.0064637139483137 0.0045272252771464 0 0 0 0 K09938 0.0 0.0398860398860398 K09938; uncharacterized protein 251.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 COG3249 Uncharacterized_conserved_protein,_DUF2066_domain 14.0 0.0 1.0 0.0098844272960446 0.0194143657149395 0.014649396505492 0.0095299384188949 0 0 0 0 K09939 0.0 0.0797720797720797 K09939; uncharacterized protein 114.0 26.0 22.0 3.0 0.838709677419355 S 0.0 31.0 2.0 0.870967741935484 COG3295 Uncharacterized_conserved_protein 31.0 0.0 1.0 0.012359378759049 0.0280357616724423 0.0201975702157456 0.0156763829133933 0 0 0 0 K09940 0.0885714285714285 0.1652421652421652 K09940; uncharacterized protein 60.0 89.0 73.0 4.0 0.787610619469027 S 41.0 72.0 4.0 0.876106194690266 COG3296 Uncharacterized_Tic20-related_protein,_DUF4870_domain Tic20a 113.0 0.3628318584070796 0.6371681415929203 0.0097998726883332 0.259544883257426 0.1346723779728796 0.2497450105690927 0 0 0 0 K09941 0.0 0.0398860398860398 K09941; uncharacterized protein 169.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 COG3310 Uncharacterized_conserved_protein,_DUF1415_family 14.0 0.0 1.0 0.0061364720675015 0.0152797223729927 0.0107080972202471 0.0091432503054912 0 0 0 0 K09942 0.0085714285714285 0.1282051282051282 K09942; uncharacterized protein 58.0 35.0 28.0 7.0 0.660377358490566 S 3.0 50.0 6.0 0.830188679245283 COG3330 Uncharacterized_conserved_protein_BH1414 53.0 0.0566037735849056 0.9433962264150944 0.022054331104915 0.261499613394185 0.14177697224955 0.2394452822892699 0 0 0 0 K09943 0.0 0.0142450142450142 K09943; uncharacterized protein 132.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG3399 Uncharacterized_conserved_protein 6.0 0.0 1.0 0.0125159513383619 0.0285605419979455 0.0205382466681537 0.0160445906595836 0 0 0 0 K09944 0.0085714285714285 0.0284900284900284 K09944; uncharacterized protein 243.0 5.0 1.0 4.0 0.357142857142857 S 3.0 11.0 4.0 0.357142857142857 COG3400 Uncharacterized_protein_AQ_414,_contains_TrkA_and_USP-like_domains 14.0 0.2142857142857142 0.7857142857142857 0.0980919656084906 0.548660556653472 0.3233762611309813 0.4505685910449814 0 0 0 0 K09945 0.0 0.037037037037037 K09945; uncharacterized protein 177.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG3416 Uncharacterized_conserved_protein,_DUF2076_domain 15.0 0.0 1.0 0.0094007524851726 0.0174797609794773 0.0134402567323249 0.0080790084943046 0 0 0 0 K09946 0.0971428571428571 0.0997150997150997 K09946; uncharacterized protein 55.0 82.0 80.0 2.0 0.976190476190476 S 37.0 47.0 3.0 0.690476190476191 COG3422 Uncharacterized_conserved_protein_YegP,_UPF0339_family YegP 84.0 0.4404761904761904 0.5595238095238095 0.143111804241606 0.147883130444766 0.145497467343186 0.00477132620316 0 0 0 0 K09947 0.0 0.0455840455840455 K09947; uncharacterized protein 301.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 COG3490 Uncharacterized_conserved_protein,_DUF1513_domain 16.0 0.0 1.0 0.0128881197498702 0.0299725671466702 0.0214303434482702 0.0170844473967999 0 0 0 0 K09948 0.0 0.094017094017094 K09948; uncharacterized protein 94.0 34.0 0.0 1.0 1.0 S 0.0 34.0 1.0 1.0 COG3492 Uncharacterized_conserved_protein,_DUF1244_family 34.0 0.0 1.0 0.0039243708678367 0.01023577423442 0.0070800725511283 0.0063114033665833 0 0 0 0 K09949 0.0 0.3333333333333333 lpxI; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 135.0 130.0 128.0 2.0 0.984848484848485 S 0.0 132.0 2.0 0.704545454545455 COG3494 Uncharacterized_conserved_protein,_DUF1009_family 132.0 0.0 1.0 0.0057722819234063 0.121980712855533 0.0638764973894696 0.1162084309321267 0 0 0 0 K09950 0.0 0.0683760683760683 K09950; uncharacterized protein 92.0 29.0 0.0 1.0 1.0 S 0.0 29.0 1.0 1.0 COG3495 Uncharacterized_conserved_protein,_DUF3299_family 29.0 0.0 1.0 0.0161836115288544 0.0508011061765946 0.0334923588527245 0.0346174946477402 0 0 0 0 K09951 0.3742857142857143 0.4387464387464387 cas2; CRISPR-associated protein Cas2 25.0 310.0 203.0 3.0 0.734597156398104 L 166.0 256.0 6.0 0.841232227488152 COG1343 CRISPR/Cas_system-associated_endoribonuclease_Cas2 Cas2 422.0 0.3933649289099526 0.6066350710900474 0.168273554523221 0.776162772597838 0.4722181635605295 0.6078892180746169 0 0 0 0 K09952 0.0 0.0911680911680911 csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] 451.0 36.0 0.0 1.0 1.0 L 0.0 36.0 1.0 1.0 COG3513 CRISPR-Cas_system_type-II_protein_Cas9 Cas9 36.0 0.0 1.0 0.0404267783980215 0.10129191059191 0.0708593444949657 0.0608651321938885 0 0 0 0 K09953 0.0 0.0056980056980056 lpxR; lipid A 3-O-deacylase [EC:3.1.1.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 297.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3528 Uncharacterized_conserved_protein,_DUF2219_family 2.0 0.0 1.0 0 0 0 0 K09954 0.0 0.0968660968660968 K09954; uncharacterized protein 64.0 33.0 32.0 2.0 0.970588235294117 S 0.0 34.0 1.0 1.0 COG3530 Uncharacterized_conserved_protein,_DUF3820_family 34.0 0.0 1.0 0.0043715752859436 0.0089966192139192 0.0066840972499314 0.0046250439279755 0 0 0 0 K09955 0.04 0.168091168091168 K09955; uncharacterized protein 217.0 114.0 97.0 7.0 0.826086956521739 S 17.0 121.0 10.0 0.920289855072464 COG3533 Beta-L-arabinofuranosidase,_GH127_family HybA1 138.0 0.1231884057971014 0.8768115942028986 0.236319442787362 0.198806895795454 0.217563169291408 0.037512546991908 0 0 0 0 K09956 0.0 0.0484330484330484 K09956; uncharacterized protein 79.0 15.0 12.0 2.0 0.833333333333333 S 0.0 18.0 1.0 1.0 COG3553 Uncharacterized_conserved_protein,_DUF2218_domain 18.0 0.0 1.0 0.015662265829977 0.0572590433562057 0.0364606545930913 0.0415967775262287 0 0 0 0 K09957 0.0114285714285714 0.0341880341880341 K09957; uncharacterized protein 163.0 13.0 0.0 1.0 1.0 S 4.0 12.0 1.0 1.0 COG3554 Uncharacterized_conserved_protein 16.0 0.25 0.75 0.0186509147855453 0.0352634168868675 0.0269571658362064 0.0166125021013222 0 0 0 0 K09958 0.0057142857142857 0.1282051282051282 K09958; uncharacterized protein 129.0 47.0 45.0 3.0 0.92156862745098 S 2.0 49.0 3.0 0.941176470588235 COG3558 Uncharacterized_conserved_protein,_nuclear_transport_factor_2_(NTF2)_superfamily 51.0 0.0392156862745098 0.9607843137254902 0.0101297478794307 0.0267122654535185 0.0184210066664746 0.0165825175740878 0 0 0 0 K09959 0.0057142857142857 0.1196581196581196 K09959; uncharacterized protein 110.0 44.0 42.0 2.0 0.956521739130435 S 2.0 44.0 2.0 0.956521739130435 COG3564 Uncharacterized_conserved_protein,_DUF779_family 46.0 0.0434782608695652 0.9565217391304348 0.0115477435497227 0.0264941783323063 0.0190209609410145 0.0149464347825836 0 0 0 0 K09960 0.0 0.0056980056980056 K09960; uncharacterized protein 317.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3566 Uncharacterized_conserved_protein,_DUF2213_domain 2.0 0.0 1.0 0 0 0 0 K09961 0.0114285714285714 0.0085470085470085 K09961; uncharacterized protein 368.0 7.0 0.0 1.0 1.0 S 4.0 3.0 2.0 0.571428571428571 COG3567 Uncharacterized_conserved_protein,_DUF1073_domain 7.0 0.5714285714285714 0.4285714285714285 0.0730660211116903 0.160984065268374 0.1170250431900321 0.0879180441566837 0 0 0 0 K09962 0.0 0.0484330484330484 K09962; uncharacterized protein 143.0 16.0 13.0 4.0 0.761904761904762 S 0.0 21.0 2.0 0.952380952380952 COG3575 Uncharacterized_conserved_protein 21.0 0.0 1.0 0.0183917174576493 0.0502546392154803 0.0343231783365648 0.0318629217578309 0 0 0 0 K09963 0.0171428571428571 0.0626780626780626 K09963; uncharacterized protein 224.0 39.0 38.0 2.0 0.975 S 9.0 31.0 1.0 1.0 COG3589 Uncharacterized_conserved_protein,_DUF871_domain 40.0 0.225 0.775 0.01267000892055 0.192528634379937 0.1025993216502435 0.179858625459387 0 0 0 0 K09964 0.0228571428571428 0.0683760683760683 K09964; uncharacterized protein 99.0 25.0 20.0 4.0 0.735294117647059 S 10.0 24.0 2.0 0.647058823529412 COG3602 ACT_domain,_ACT-3_family ACT-3 34.0 0.2941176470588235 0.7058823529411765 0.0295577093554494 0.0487519314698096 0.0391548204126295 0.0191942221143602 0 0 0 0 K09965 0.0 0.0398860398860398 K09965; uncharacterized protein 180.0 11.0 8.0 2.0 0.785714285714286 S 0.0 14.0 1.0 1.0 COG3644 Uncharacterized_conserved_protein,_DUF2239_domain 14.0 0.0 1.0 0.0256972391514482 0.0628470715462964 0.0442721553488723 0.0371498323948482 0 0 0 0 K09966 0.0857142857142857 0.1367521367521367 K09966; uncharacterized protein 116.0 77.0 76.0 2.0 0.987179487179487 S 30.0 48.0 1.0 1.0 COG3651 Uncharacterized_conserved_protein,_DUF2237_family 78.0 0.3846153846153846 0.6153846153846154 0.0024769809153079 0.0189624837754565 0.0107197323453822 0.0164855028601486 0 0 0 0 K09967 0.0028571428571428 0.1196581196581196 K09967; uncharacterized protein 145.0 73.0 71.0 2.0 0.973333333333333 S 1.0 74.0 2.0 0.986666666666667 COG3665 Uncharacterized_conserved_protein_YcgI,_DUF1989_family YcgI 75.0 0.0133333333333333 0.9866666666666668 0.035592519471635 0.115982485041827 0.075787502256731 0.080389965570192 0 0 0 0 K09968 0.0 0.017094017094017 K09968; uncharacterized protein 155.0 5.0 4.0 2.0 0.833333333333333 O 0.0 6.0 2.0 0.833333333333333 COG3680 Uncharacterized_protein,_contains_GIY-YIG_domain 6.0 0.0 1.0 0.159538697221639 0.305795456687212 0.2326670769544254 0.1462567594655729 0 0 0 0 K09969 0.0114285714285714 0.1709401709401709 aapJ, bztA; general L-amino acid transport system substrate-binding protein path:map02010 ABC transporters 275.0 84.0 0.0 1.0 1.0 ET 6.0 78.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 84.0 0.0714285714285714 0.9285714285714286 0.0017103471264799 0.192040734209712 0.0968755406680959 0.190330387083232 0 0 0 0 K09970 0.0171428571428571 0.131054131054131 aapQ, bztB; general L-amino acid transport system permease protein path:map02010 ABC transporters 319.0 39.0 22.0 3.0 0.68421052631579 P 6.0 51.0 2.0 0.894736842105263 COG4597 ABC-type_amino_acid_transport_system,_permease_component BatB 57.0 0.1052631578947368 0.8947368421052632 0.008276676307993 0.246960572710698 0.1276186245093455 0.238683896402705 0 0 0 0 K09971 0.0114285714285714 0.1566951566951566 aapM, bztC; general L-amino acid transport system permease protein path:map02010 ABC transporters 244.0 53.0 36.0 5.0 0.716216216216216 P 4.0 70.0 4.0 0.932432432432432 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 74.0 0.054054054054054 0.945945945945946 0.0029786664799101 0.527776454100958 0.265377560290434 0.5247977876210479 0 0 0 0 K09972 0.0114285714285714 0.188034188034188 aapP, bztD; general L-amino acid transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 231.0 105.0 95.0 2.0 0.91304347826087 E 4.0 111.0 2.0 0.982608695652174 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 115.0 0.0347826086956521 0.9652173913043478 0.0069006434926375 0.0053718079302264 0.0061362257114319 0.001528835562411 0 0 0 0 K09973 0.0 0.1566951566951566 K09973; uncharacterized protein 71.0 59.0 55.0 4.0 0.893939393939394 S 0.0 66.0 4.0 0.893939393939394 COG3735 Uncharacterized_conserved_protein_YbaP,_TraB_family TraB 66.0 0.0 1.0 0.0191553938574532 0.0148012430011644 0.0169783184293088 0.0043541508562887 0 0 0 0 K09974 0.0 0.037037037037037 K09974; uncharacterized protein 171.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3738 Uncharacterized_conserved_protein_YijF,_DUF1287_family YiijF 13.0 0.0 1.0 0.0354938612276478 0.0868267354942511 0.0611602983609494 0.0513328742666033 0 0 0 0 K09975 0.0 0.0484330484330484 K09975; uncharacterized protein 133.0 18.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG3758 Various_environmental_stresses-induced_protein_Ves_(function_unknown) Ves 18.0 0.0 1.0 0.0231466474583554 0.0603607961317957 0.0417537217950755 0.0372141486734403 0 0 0 0 K09976 0.0 0.0598290598290598 K09976; uncharacterized protein 66.0 21.0 0.0 1.0 1.0 S 0.0 21.0 1.0 1.0 COG3763 Uncharacterized_conserved_protein_YneF,_UPF0154_family YneF 21.0 0.0 1.0 0.0020073470028594 0.0030397952249367 0.002523571113898 0.0010324482220773 0 0 0 0 K09977 0.0 0.037037037037037 K09977; uncharacterized protein 165.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 COG3782 Uncharacterized_conserved_protein,_DUF1853_domain 14.0 0.0 1.0 0.0064309200874683 0.0138600925262326 0.0101455063068504 0.0074291724387643 0 0 0 0 K09978 0.0 0.1025641025641025 K09978; uncharacterized protein 82.0 36.0 0.0 1.0 1.0 S 0.0 36.0 1.0 1.0 COG3784 Uncharacterized_conserved_protein_YdbL,_DUF1318_family YdbL 36.0 0.0 1.0 0.0102070665017854 0.030048568023069 0.0201278172624272 0.0198415015212835 0 0 0 0 K09979 0.0057142857142857 0.0484330484330484 K09979; uncharacterized protein 100.0 19.0 18.0 2.0 0.95 S 2.0 18.0 2.0 0.95 COG3787 Uncharacterized_conserved_protein_YhbP,_UPF0306_family YhbP 20.0 0.1 0.9 0.0149334539923238 0.158187501447861 0.0865604777200924 0.1432540474555372 0 0 0 0 K09980 0.0 0.0142450142450142 K09980; uncharacterized protein 129.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3789 Uncharacterized_conserved_protein_YjfI,_DUF2170_family YjfI 5.0 0.0 1.0 0.0768459381807638 0.166744723305504 0.1217953307431339 0.0898987851247402 0 0 0 0 K09981 0.0171428571428571 0.1424501424501424 K09981; uncharacterized protein 35.0 63.0 0.0 1.0 1.0 S 9.0 54.0 1.0 1.0 COG3809 Predicted_nucleic_acid-binding_protein,_contains_Zn-finger_domain 63.0 0.1428571428571428 0.8571428571428571 0.065322525614036 0.0605127361888972 0.0629176309014666 0.0048097894251387 0 0 0 0 K09982 0.0 0.0256410256410256 K09982; uncharacterized protein 85.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 COG3811 Uncharacterized_conserved_protein_YjhX,_UPF0386/DUF2084_family YjhX 9.0 0.0 1.0 0.0184132531140092 0.0433776121915248 0.030895432652767 0.0249643590775156 0 0 0 0 K09983 0.0 0.0455840455840455 K09983; uncharacterized protein 151.0 19.0 0.0 1.0 1.0 S 0.0 19.0 1.0 1.0 COG3812 Uncharacterized_conserved_protein,_DUF1993_domain 19.0 0.0 1.0 0.0163208128067823 0.0402643456431339 0.0282925792249581 0.0239435328363516 0 0 0 0 K09984 0.0 0.037037037037037 K09984; uncharacterized protein 75.0 11.0 9.0 2.0 0.846153846153846 S 0.0 13.0 1.0 1.0 COG3813 Uncharacterized_conserved_protein,_DUF1272_domain 13.0 0.0 1.0 0.0298289322995726 0.0785515460217082 0.0541902391606404 0.0487226137221356 0 0 0 0 K09985 0.0 0.1139601139601139 K09985; uncharacterized protein 101.0 41.0 0.0 1.0 1.0 S 0.0 41.0 2.0 0.829268292682927 COG3814 SspB-like_protein,_predicted_to_bind_SsrA_peptide SspB2 41.0 0.0 1.0 0.0033223393423938 0.0084739472713416 0.0058981433068676 0.0051516079289478 0 0 0 0 K09986 0.0 0.1196581196581196 K09986; uncharacterized protein 118.0 37.0 33.0 2.0 0.902439024390244 S 0.0 44.0 2.0 0.931818181818182 COG3816 Uncharacterized_conserved_protein,_DUF1285_family 44.0 0.0 1.0 0.0028046790193499 0.0074522044968496 0.0051284417580997 0.0046475254774997 0 0 0 0 K09987 0.0 0.094017094017094 K09987; uncharacterized protein 173.0 33.0 0.0 1.0 1.0 S 0.0 33.0 1.0 1.0 COG3820 Uncharacterized_conserved_protein,_DUF1013_family 33.0 0.0 1.0 3.07956914290116e-09 0.0020874565390945 0.0010437298093318 0.0020874534595253 0 0 0 0 K09988 0.0142857142857142 0.0797720797720797 lyxA; D-lyxose ketol-isomerase [EC:5.3.1.15] path:map00040 Pentose and glucuronate interconversions 146.0 33.0 29.0 2.0 0.891891891891892 S 6.0 31.0 2.0 0.864864864864865 COG3822 D-lyxose_ketol-isomerase YdaE 37.0 0.1621621621621621 0.8378378378378378 0.871018270977415 0.937533201605258 0.9042757362913364 0.0665149306278429 1 1 1 1 K09989 0.0228571428571428 0.1481481481481481 K09989; uncharacterized protein 328.0 68.0 67.0 2.0 0.985507246376812 S 9.0 60.0 1.0 1.0 COG3825 Uncharacterized_CoxE-like_protein,__contains_von_Willebrand_factor_type_A_(vWA)_domain CoxE2 69.0 0.1304347826086956 0.8695652173913043 0.004883253146832 0.0039455788965491 0.0044144160216905 0.0009376742502829 0 0 0 0 K09990 0.0 0.0484330484330484 K09990; uncharacterized protein 230.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG3826 Uncharacterized_conserved_protein 17.0 0.0 1.0 0.0286729472062111 0.0653996138169281 0.0470362805115696 0.036726666610717 0 0 0 0 K09991 0.0 0.0512820512820512 K09991; uncharacterized protein 100.0 15.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG3827 Cell_pole-organizing_protein_PopZ PopZ 18.0 0.0 1.0 0.0057192885035971 0.0124498210008138 0.0090845547522054 0.0067305324972167 0 0 0 0 K09992 0.0314285714285714 0.1538461538461538 K09992; uncharacterized protein 57.0 56.0 35.0 6.0 0.478632478632479 S 13.0 102.0 7.0 0.641025641025641 COG3828 Type_1_glutamine_amidotransferase_(GATase1)-like_domain 115.0 0.1130434782608695 0.8869565217391304 0.0533856317960825 0.0257559345283436 0.039570783162213 0.0276296972677389 0 0 0 0 K09994 0.0 0.0113960113960113 phnO; (aminoalkyl)phosphonate N-acetyltransferase [EC:2.3.1.280] path:map00440 Phosphonate and phosphinate metabolism 122.0 3.0 2.0 2.0 0.75 K 0.0 4.0 2.0 0.75 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 4.0 0.0 1.0 0.0649901365520393 0.133307659469168 0.0991488980106036 0.0683175229171287 0 0 0 0 K09996 0.0 0.037037037037037 artJ; arginine transport system substrate-binding protein path:map02010 ABC transporters 202.0 20.0 18.0 2.0 0.909090909090909 ET 0.0 22.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 22.0 0.0 1.0 0.0047647049593313 0.0125232231418845 0.0086439640506079 0.0077585181825532 0 0 0 0 K09997 0.0 0.0341880341880341 artI; arginine transport system substrate-binding protein path:map02010 ABC transporters 235.0 14.0 0.0 1.0 1.0 ET 0.0 14.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 14.0 0.0 1.0 0.0044800992557363 0.0086467377978696 0.0065634185268029 0.0041666385421333 0 0 0 0 K09998 0.0 0.0113960113960113 artM; arginine transport system permease protein path:map02010 ABC transporters 221.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG4160 ABC-type_arginine/histidine_transport_system,_permease_component ArtM 4.0 0.0 1.0 2.13459702067918e-21 4.3123260178399897e-13 2.15616301959298e-13 4.3123259964940205e-13 0 0 0 0 K09999 0.0 0.0142450142450142 artQ; arginine transport system permease protein path:map02010 ABC transporters 217.0 4.0 3.0 2.0 0.8 P 0.0 5.0 1.0 1.0 COG4215 ABC-type_arginine_transport_system,_permease_component ArtQ 5.0 0.0 1.0 5.80889286534274e-05 6.6441444858248496e-12 2.9044467648785946e-05 5.808892200928292e-05 0 0 0 0 K10000 0.0 0.0113960113960113 artP; arginine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 242.0 3.0 2.0 2.0 0.75 E 0.0 4.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 4.0 0.0 1.0 1.84455900982013e-21 4.53707681462566e-13 2.268538416535625e-13 4.53707679618007e-13 0 0 0 0 K10001 0.0 0.0512820512820512 gltI, aatJ; glutamate/aspartate transport system substrate-binding protein path:map02010,path:map02020 ABC transporters,Two-component system 250.0 26.0 0.0 1.0 1.0 ET 0.0 26.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 26.0 0.0 1.0 0.0057471831109747 0.0187020928856941 0.0122246379983344 0.0129549097747194 0 0 0 0 K10002 0.0 0.0626780626780626 gltK, aatM; glutamate/aspartate transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 192.0 22.0 19.0 2.0 0.88 P 0.0 25.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 25.0 0.0 1.0 0.0337066974910998 0.0605447226875883 0.047125710089344 0.0268380251964885 0 0 0 0 K10003 0.0 0.0427350427350427 gltJ, aatQ; glutamate/aspartate transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 230.0 15.0 14.0 2.0 0.9375 P 0.0 16.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 16.0 0.0 1.0 0.0377012246458271 0.0811374470891358 0.0594193358674814 0.0434362224433087 0 0 0 0 K10004 0.0 0.0826210826210826 gltL, aatP; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1] path:map02010,path:map02020 ABC transporters,Two-component system 237.0 43.0 39.0 2.0 0.914893617021277 E 0.0 47.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 47.0 0.0 1.0 0.0039034653298573 0.010915591039378 0.0074095281846176 0.0070121257095207 0 0 0 0 K10005 0.0 0.0683760683760683 gluB; glutamate transport system substrate-binding protein path:map02010 ABC transporters 214.0 36.0 0.0 1.0 1.0 ET 0.0 36.0 2.0 0.972222222222222 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 36.0 0.0 1.0 0.0017354639655441 0.0045615451836835 0.0031485045746138 0.0028260812181394 0 0 0 0 K10006 0.0 0.0655270655270655 gluC; glutamate transport system permease protein path:map02010 ABC transporters 193.0 17.0 9.0 2.0 0.68 E 0.0 25.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 25.0 0.0 1.0 0.0049401841149747 0.0240481490979743 0.0144941666064745 0.0191079649829996 0 0 0 0 K10007 0.0 0.0683760683760683 gluD; glutamate transport system permease protein path:map02010 ABC transporters 241.0 15.0 4.0 2.0 0.576923076923077 E 0.0 26.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 26.0 0.0 1.0 0.0045163497553626 0.0246302607700909 0.0145733052627267 0.0201139110147283 0 0 0 0 K10008 0.0 0.074074074074074 gluA; glutamate transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 244.0 27.0 0.0 1.0 1.0 E 0.0 27.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 27.0 0.0 1.0 0.0060476299648938 0.0167530324679171 0.0114003312164054 0.0107054025030233 0 0 0 0 K10009 0.0 0.0769230769230769 tcyB, yecS; L-cystine transport system permease protein path:map02010 ABC transporters 192.0 19.0 5.0 3.0 0.542857142857143 P 0.0 35.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 35.0 0.0 1.0 0.0235114702313777 0.023801618733766 0.0236565444825718 0.0002901485023882 0 0 0 0 K10010 0.0 0.0626780626780626 tcyC, yecC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 227.0 24.0 19.0 2.0 0.827586206896552 E 0.0 29.0 2.0 0.96551724137931 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 29.0 0.0 1.0 0.0485019173629599 0.0474934450640113 0.0479976812134856 0.0010084722989485 0 0 0 0 K10011 0.0028571428571428 0.0569800569800569 arnA, pmrI; UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) [EC:2.1.2.13 1.1.1.305] path:map00520,path:map01100,path:map01250,path:map01503 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars,Cationic antimicrobial peptide (CAMP) resistance 14.0 9.0 2.0 5.0 0.391304347826087 GM 1.0 21.0 2.0 0.565217391304348 COG0223 Methionyl-tRNA_formyltransferase Fmt 22.0 0.0454545454545454 0.9545454545454546 0.0253164133013645 0.0914127547473565 0.0583645840243605 0.066096341445992 0 0 0 0 K10012 0.0028571428571428 0.0968660968660968 arnC, pmrF; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [EC:2.4.2.53] path:map00520,path:map01100,path:map01503 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance 263.0 39.0 38.0 2.0 0.975 M 1.0 39.0 2.0 0.975 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 40.0 0.025 0.975 0.0712808707014527 0.314032693536789 0.1926567821191208 0.2427518228353362 0 0 0 0 K10013 0.0 0.0085470085470085 argT; lysine/arginine/ornithine transport system substrate-binding protein path:map02010 ABC transporters 259.0 5.0 0.0 1.0 1.0 ET 0.0 5.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 5.0 0.0 1.0 0.0039828768147093 5.822574424601691e-09 0.0019914413186418 0.0039828709921348 0 0 0 0 K10014 0.0 0.0256410256410256 hisJ; histidine transport system substrate-binding protein path:map02010 ABC transporters 235.0 15.0 0.0 1.0 1.0 ET 0.0 15.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 15.0 0.0 1.0 0.0055401309610844 0.0143373454442346 0.0099387382026595 0.0087972144831502 0 0 0 0 K10015 0.0 0.0113960113960113 hisM; histidine transport system permease protein path:map02010 ABC transporters 221.0 2.0 0.0 2.0 0.5 E 0.0 4.0 1.0 1.0 COG4160 ABC-type_arginine/histidine_transport_system,_permease_component ArtM 4.0 0.0 1.0 0.0447791777223137 0.112288015922282 0.0785335968222978 0.0675088381999683 0 0 0 0 K10016 0.0 0.017094017094017 hisQ; histidine transport system permease protein path:map02010 ABC transporters 227.0 5.0 4.0 2.0 0.833333333333333 P 0.0 6.0 1.0 1.0 COG4215 ABC-type_arginine_transport_system,_permease_component ArtQ 6.0 0.0 1.0 0.0695120088700045 0.157778725314087 0.1136453670920457 0.0882667164440824 0 0 0 0 K10017 0.0 0.0085470085470085 hisP; histidine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 254.0 2.0 1.0 2.0 0.666666666666667 E 0.0 3.0 1.0 1.0 COG4598 ABC-type_histidine_transport_system,_ATPase_component HisP 3.0 0.0 1.0 0 0 0 0 K10018 0.0 0.0284900284900284 occT, nocT; octopine/nopaline transport system substrate-binding protein path:map02010 ABC transporters 270.0 14.0 0.0 1.0 1.0 ET 0.0 14.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 14.0 0.0 1.0 0.0051968029285691 0.0170130024228468 0.0111049026757079 0.0118161994942776 0 0 0 0 K10019 0.0 0.037037037037037 occM, nocM; octopine/nopaline transport system permease protein path:map02010 ABC transporters 220.0 10.0 4.0 2.0 0.625 E 0.0 16.0 1.0 1.0 COG4160 ABC-type_arginine/histidine_transport_system,_permease_component ArtM 16.0 0.0 1.0 0.0112443307646116 0.0274268937873771 0.0193356122759943 0.0161825630227655 0 0 0 0 K10020 0.0 0.037037037037037 occQ, nocQ; octopine/nopaline transport system permease protein path:map02010 ABC transporters 223.0 13.0 8.0 2.0 0.722222222222222 E 0.0 18.0 1.0 1.0 COG4215 ABC-type_arginine_transport_system,_permease_component ArtQ 18.0 0.0 1.0 0.0068321211074372 0.019973610501115 0.0134028658042761 0.0131414893936778 0 0 0 0 K10021 0.0 0.037037037037037 occP, nocP; octopine/nopaline transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 250.0 16.0 0.0 1.0 1.0 E 0.0 16.0 1.0 1.0 COG4598 ABC-type_histidine_transport_system,_ATPase_component HisP 16.0 0.0 1.0 2.09142042723618e-12 0.0048756069196363 0.0024378034608638 0.0048756069175448 0 0 0 0 K10022 0.0 0.0284900284900284 aotJ; arginine/ornithine transport system substrate-binding protein path:map02010 ABC transporters 237.0 11.0 0.0 1.0 1.0 ET 0.0 11.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 11.0 0.0 1.0 0.0096269979068012 0.0256189804698739 0.0176229891883375 0.0159919825630727 0 0 0 0 K10023 0.0 0.0199430199430199 aotM; arginine/ornithine transport system permease protein path:map02010 ABC transporters 228.0 4.0 1.0 2.0 0.571428571428571 E 0.0 7.0 1.0 1.0 COG4160 ABC-type_arginine/histidine_transport_system,_permease_component ArtM 7.0 0.0 1.0 0.0356833141482224 0.135372562924905 0.0855279385365637 0.0996892487766825 0 0 0 0 K10024 0.0 0.0227920227920227 aotQ; arginine/ornithine transport system permease protein path:map02010 ABC transporters 224.0 7.0 6.0 2.0 0.875 P 0.0 8.0 1.0 1.0 COG4215 ABC-type_arginine_transport_system,_permease_component ArtQ 8.0 0.0 1.0 0.0359074927601541 0.0857135146290021 0.0608105036945781 0.049806021868848 0 0 0 0 K10025 0.0 0.0512820512820512 aotP; arginine/ornithine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 249.0 18.0 0.0 1.0 1.0 E 0.0 18.0 1.0 1.0 COG4598 ABC-type_histidine_transport_system,_ATPase_component HisP 18.0 0.0 1.0 0.0126856036267866 0.0368836999696136 0.0247846517982 0.0241980963428269 0 0 0 0 K10026 0.48 0.5584045584045584 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 60.0 345.0 315.0 4.0 0.903141361256544 H 172.0 210.0 2.0 0.973821989528796 COG0602 Organic_radical_activating_enzyme_NrdG/QueE QueE 382.0 0.450261780104712 0.5497382198952879 0.160624447149496 0.540532158100082 0.350578302624789 0.379907710950586 0 0 0 0 K10027 0.14 0.2706552706552707 crtI; phytoene desaturase [EC:1.3.99.26 1.3.99.28 1.3.99.29 1.3.99.31] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 251.0 159.0 144.0 3.0 0.903409090909091 Q 57.0 118.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 175.0 0.3257142857142857 0.6742857142857143 0.0030459315114858 0.187698447757887 0.0953721896346864 0.1846525162464012 0 0 0 0 K10036 0.0057142857142857 0.0541310541310541 glnH; glutamine transport system substrate-binding protein path:map02010 ABC transporters 213.0 18.0 12.0 2.0 0.75 ET 2.0 22.0 2.0 0.75 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 24.0 0.0833333333333333 0.9166666666666666 0.0109071408449039 0.016341508830164 0.0136243248375339 0.0054343679852601 0 0 0 0 K10037 0.0 0.0341880341880341 glnP; glutamine transport system permease protein path:map02010 ABC transporters 218.0 14.0 13.0 2.0 0.933333333333333 P 0.0 15.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 15.0 0.0 1.0 0.0319808380244047 0.0879060474383461 0.0599434427313754 0.0559252094139414 0 0 0 0 K10038 0.0142857142857142 0.0512820512820512 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 224.0 29.0 23.0 3.0 0.805555555555556 E 5.0 31.0 3.0 0.916666666666667 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 36.0 0.1388888888888889 0.8611111111111112 0.0124804394964359 0.0284898077867338 0.0204851236415848 0.0160093682902979 0 0 0 0 K10039 0.0 0.0512820512820512 peb1A, glnH; aspartate/glutamate/glutamine transport system substrate-binding protein path:map02010 ABC transporters 236.0 19.0 0.0 1.0 1.0 ET 0.0 19.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 19.0 0.0 1.0 0.0364290432466391 0.0801368188496855 0.0582829310481623 0.0437077756030464 0 0 0 0 K10040 0.0028571428571428 0.0569800569800569 peb1B, glnP, glnM; aspartate/glutamate/glutamine transport system permease protein path:map02010 ABC transporters 183.0 22.0 10.0 2.0 0.647058823529412 P 1.0 33.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 34.0 0.0294117647058823 0.9705882352941176 0.0475305532749544 0.240139752633421 0.1438351529541877 0.1926091993584666 0 0 0 0 K10041 0.0028571428571428 0.0541310541310541 peb1C, glnQ; aspartate/glutamate/glutamine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 231.0 21.0 0.0 1.0 1.0 E 1.0 20.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 21.0 0.0476190476190476 0.9523809523809524 5.52656800665907e-12 0.187226829222876 0.0936134146142012 0.1872268292173494 0 0 0 0 K10085 0.0028571428571428 0.0 EDEM2; ER degradation enhancer, mannosidase alpha-like 2 path:map04141 Protein processing in endoplasmic reticulum 62.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2DBJC 1.0 1.0 0.0 0 0 0 0 K10089 0.0028571428571428 0.0 M6PR; cation-dependent mannose-6-phosphate receptor path:map04142,path:map04145,path:map05132 Lysosome,Phagosome,Salmonella infection 210.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 1.0 1.0 0.0 0 0 0 0 K10094 0.0 0.0284900284900284 cbiK; nickel transport protein path:map02010 ABC transporters 215.0 12.0 0.0 1.0 1.0 P 0.0 12.0 1.0 1.0 COG5266 Uncharacterized_protein,_contains_GH25_family_domain 12.0 0.0 1.0 0.0723362985676046 0.166208191141063 0.1192722448543338 0.0938718925734584 0 0 0 0 K10107 0.0 0.0569800569800569 kpsE; capsular polysaccharide transport system permease protein path:map02010 ABC transporters 326.0 28.0 0.0 1.0 1.0 M 0.0 28.0 1.0 1.0 COG3524 Capsule_polysaccharide_export_protein_KpsE/RkpR KpsE 28.0 0.0 1.0 0.0085376376401343 0.015396346404418 0.0119669920222761 0.0068587087642837 0 0 0 0 K10108 0.0 0.0398860398860398 malE; maltose/maltodextrin transport system substrate-binding protein path:map02010,path:map02030 ABC transporters,Bacterial chemotaxis 349.0 18.0 17.0 2.0 0.947368421052632 G 0.0 19.0 1.0 1.0 COG2182 Maltose-binding_periplasmic_protein_MalE MalE 19.0 0.0 1.0 0.938042369519347 0.488522637202048 0.7132825033606975 0.449519732317299 0 0 1 1 K10109 0.0114285714285714 0.0712250712250712 malF; maltose/maltodextrin transport system permease protein path:map02010 ABC transporters 222.0 50.0 48.0 2.0 0.961538461538462 P 4.0 48.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 52.0 0.0769230769230769 0.9230769230769232 0.986096399368172 0.936162883775546 0.961129641571859 0.0499335155926259 1 1 1 1 K10110 0.0142857142857142 0.0655270655270655 malG; maltose/maltodextrin transport system permease protein path:map02010 ABC transporters 178.0 17.0 10.0 4.0 0.515151515151515 P 5.0 28.0 3.0 0.515151515151515 COG3833 ABC-type_maltose_transport_system,_permease_component_MalG MalG 33.0 0.1515151515151515 0.8484848484848485 0.989180884077268 0.800797171304375 0.8949890276908214 0.188383712772893 1 1 1 1 K10111 0.0028571428571428 0.1225071225071225 malK, mtlK, thuK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] path:map02010 ABC transporters 290.0 56.0 27.0 2.0 0.658823529411765 P 1.0 84.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 85.0 0.0117647058823529 0.9882352941176472 0.31436072579117 0.0168712661114708 0.1656159959513204 0.2974894596796992 0 0 0 0 K10112 0.3371428571428571 0.5612535612535613 msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] path:map02010 ABC transporters 190.0 355.0 62.0 4.0 0.476510067114094 E 327.0 414.0 6.0 0.536912751677852 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 741.0 0.4412955465587044 0.5587044534412956 0.60411867677034 0.767678074563426 0.685898375666883 0.1635593977930859 0 1 0 1 K10117 0.0028571428571428 0.1823361823361823 msmE; raffinose/stachyose/melibiose transport system substrate-binding protein path:map02010 ABC transporters 71.0 156.0 155.0 3.0 0.987341772151899 G 1.0 157.0 3.0 0.949367088607595 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 158.0 0.0063291139240506 0.9936708860759492 0.025057129879612 0.152691156079337 0.0888741429794745 0.127634026199725 0 0 0 0 K10118 0.0085714285714285 0.2165242165242165 msmF; raffinose/stachyose/melibiose transport system permease protein path:map02010 ABC transporters 129.0 150.0 70.0 3.0 0.643776824034335 P 3.0 230.0 2.0 0.982832618025751 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 233.0 0.0128755364806866 0.9871244635193132 0.613122141007508 0.546409968911733 0.5797660549596204 0.0667121720957749 0 0 0 1 K10119 0.0 0.1709401709401709 msmG; raffinose/stachyose/melibiose transport system permease protein path:map02010 ABC transporters 197.0 80.0 24.0 3.0 0.583941605839416 P 0.0 137.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 137.0 0.0 1.0 0.0459996812534315 0.0294766759478251 0.0377381786006283 0.0165230053056063 0 0 0 0 K10120 0.0 0.0142450142450142 msmE; fructooligosaccharide transport system substrate-binding protein 417.0 5.0 0.0 1.0 1.0 G 0.0 5.0 2.0 0.6 COG2182 Maltose-binding_periplasmic_protein_MalE MalE 5.0 0.0 1.0 0.129422376529829 0.252513553600294 0.1909679650650614 0.1230911770704649 0 0 0 0 K10121 0.0 0.0028490028490028 msmF; fructooligosaccharide transport system permease protein 293.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 1.0 0.0 1.0 0 0 0 0 K10122 0.0 0.0056980056980056 msmG; fructooligosaccharide transport system permease protein 267.0 1.0 0.0 2.0 0.5 P 0.0 2.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 2.0 0.0 1.0 0 0 0 0 K10123 0.0 0.0056980056980056 feoC; putative ferrous iron transport protein C 67.0 2.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 2DGV4 2.0 0.0 1.0 0 0 0 0 K10124 0.0 0.0056980056980056 bglH; carbohydrate-specific outer membrane porin 419.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG4580 Maltoporin_(phage_lambda_and_maltose_receptor) LamB 2.0 0.0 1.0 0 0 0 0 K10125 0.0028571428571428 0.1196581196581196 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] path:map02020 Two-component system 249.0 59.0 0.0 1.0 1.0 T 1.0 58.0 5.0 0.898305084745763 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 59.0 0.0169491525423728 0.9830508474576272 0.0028201899861059 0.0043207513690258 0.0035704706775658 0.0015005613829198 0 0 0 0 K10126 0.0 0.0769230769230769 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD path:map02020 Two-component system 387.0 41.0 40.0 2.0 0.976190476190476 T 0.0 42.0 2.0 0.976190476190476 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 42.0 0.0 1.0 0.0056073323979287 0.0228346028261197 0.0142209676120242 0.017227270428191 0 0 0 0 K10143 0.0 0.0028490028490028 RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27] path:map04115,path:map04120,path:map04712 p53 signaling pathway,Ubiquitin mediated proteolysis,Circadian rhythm - plant 126.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG5641 1.0 0.0 1.0 0 0 0 0 K10150 0.0657142857142857 0.0 cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22] path:map00260,path:map00270,path:map00920,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 279.0 23.0 0.0 1.0 1.0 E 23.0 0.0 1.0 1.0 COG0031 Cysteine_synthase CysK 23.0 1.0 0.0 0.0076861571152353 0.0357494292531617 0.0217177931841985 0.0280632721379264 0 0 0 0 K10156 0.0 0.0028490028490028 eizS; epi-isozizaene synthase [EC:4.2.3.37] path:map00909,path:map01110 Sesquiterpenoid and triterpenoid biosynthesis,Biosynthesis of secondary metabolites 342.0 0.0 1.0 1.0 1.0 2CC1N 1.0 0.0 1.0 0 0 0 0 K10187 0.0 0.0313390313390313 cyc2; germacradienol/geosmin synthase [EC:4.2.3.22 4.2.3.75 4.1.99.16] path:map00909,path:map01100,path:map01110 Sesquiterpenoid and triterpenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 484.0 11.0 10.0 2.0 0.916666666666667 S 0.0 12.0 2.0 0.916666666666667 28I4I 12.0 0.0 1.0 0.0097148918709018 0.0218851860562105 0.0158000389635561 0.0121702941853086 0 0 0 0 K10188 0.0 0.0598290598290598 lacE, araN; lactose/L-arabinose transport system substrate-binding protein path:map02010 ABC transporters 271.0 31.0 0.0 1.0 1.0 G 0.0 31.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 31.0 0.0 1.0 0.475891526738602 0.954887533804063 0.7153895302713325 0.4789960070654609 0 0 0 0 K10189 0.0028571428571428 0.0797720797720797 lacF, araP; lactose/L-arabinose transport system permease protein path:map02010 ABC transporters 217.0 39.0 29.0 2.0 0.795918367346939 P 1.0 48.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 49.0 0.0204081632653061 0.979591836734694 0.219416844844465 0.281223292470132 0.2503200686572985 0.061806447625667 0 0 0 0 K10190 0.0 0.0655270655270655 lacG, araQ; lactose/L-arabinose transport system permease protein path:map02010 ABC transporters 252.0 17.0 8.0 2.0 0.653846153846154 P 0.0 26.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 26.0 0.0 1.0 0.779968175332018 0.732738361095301 0.7563532682136596 0.047229814236717 0 0 1 1 K10191 0.0028571428571428 0.0256410256410256 lacK; lactose/L-arabinose transport system ATP-binding protein path:map02010 ABC transporters 326.0 16.0 11.0 2.0 0.761904761904762 P 1.0 20.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 21.0 0.0476190476190476 0.9523809523809524 0.0132213361333007 0.0241823813672539 0.0187018587502773 0.0109610452339532 0 0 0 0 K10192 0.0 0.0256410256410256 togB; oligogalacturonide transport system substrate-binding protein path:map02010 ABC transporters 371.0 12.0 0.0 1.0 1.0 G 0.0 12.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 12.0 0.0 1.0 5.5241438012313295e-12 0.0001593174406643 7.96587230942219e-05 0.0001593174351401 0 0 0 0 K10193 0.0 0.0313390313390313 togM; oligogalacturonide transport system permease protein path:map02010 ABC transporters 264.0 13.0 10.0 3.0 0.764705882352941 P 0.0 17.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 17.0 0.0 1.0 0.0159446858641451 0.032883480558625 0.024414083211385 0.0169387946944799 0 0 0 0 K10194 0.0 0.0227920227920227 togN; oligogalacturonide transport system permease protein path:map02010 ABC transporters 275.0 6.0 4.0 2.0 0.75 P 0.0 8.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 8.0 0.0 1.0 0.0653565100757933 0.149667296722371 0.1075119033990821 0.0843107866465777 0 0 0 0 K10195 0.0 0.0113960113960113 togA; oligogalacturonide transport system ATP-binding protein path:map02010 ABC transporters 354.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 4.0 0.0 1.0 0.0569071378173743 0.123433059573802 0.0901700986955881 0.0665259217564277 0 0 0 0 K10196 0.0342857142857142 0.0 glcS, araS; glucose/arabinose transport system substrate-binding protein path:map02010 ABC transporters 366.0 15.0 12.0 2.0 0.833333333333333 G 18.0 0.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 18.0 1.0 0.0 0.006344815774875 0.0116823667725287 0.0090135912737018 0.0053375509976537 0 0 0 0 K10197 0.0342857142857142 0.0 glcT, araT; glucose/arabinose transport system permease protein path:map02010 ABC transporters 276.0 13.0 0.0 1.0 1.0 P 13.0 0.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 13.0 1.0 0.0 0.0157433298100333 0.0320266883015781 0.0238850090558057 0.0162833584915448 0 0 0 0 K10198 0.0342857142857142 0.0 glcU, araU; glucose/arabinose transport system permease protein path:map02010 ABC transporters 267.0 14.0 0.0 1.0 1.0 P 14.0 0.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 14.0 1.0 0.0 0.012015399118727 0.0251367325053436 0.0185760658120353 0.0131213333866165 0 0 0 0 K10199 0.0571428571428571 0.0 glcV, araV; glucose/arabinose transport system ATP-binding protein path:map02010 ABC transporters 316.0 14.0 4.0 3.0 0.5 E 28.0 0.0 1.0 1.0 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 28.0 1.0 0.0 0.0742126331383069 0.260346601418572 0.1672796172784394 0.1861339682802651 0 0 0 0 K10200 0.0 0.037037037037037 ngcE; N-acetylglucosamine transport system substrate-binding protein path:map02010 ABC transporters 399.0 13.0 0.0 1.0 1.0 G 0.0 13.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 13.0 0.0 1.0 0.0418985563272499 0.123477131986823 0.0826878441570364 0.0815785756595731 0 0 0 0 K10201 0.0 0.0484330484330484 ngcF; N-acetylglucosamine transport system permease protein path:map02010 ABC transporters 238.0 22.0 5.0 2.0 0.564102564102564 P 0.0 39.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 39.0 0.0 1.0 0.0043289581091493 0.00865272557262 0.0064908418408846 0.0043237674634707 0 0 0 0 K10202 0.0 0.0541310541310541 ngcG; N-acetylglucosamine transport system permease protein path:map02010 ABC transporters 252.0 11.0 1.0 3.0 0.5 P 0.0 22.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 22.0 0.0 1.0 0.0436902562493644 0.0889075964372089 0.0662989263432866 0.0452173401878445 0 0 0 0 K10206 0.2371428571428571 0.4102564102564102 E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] path:map00300,path:map01100,path:map01110,path:map01230 Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 265.0 243.0 209.0 2.0 0.877256317689531 E 84.0 193.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 277.0 0.3032490974729241 0.6967509025270758 0.679191750385599 0.148797323315697 0.413994536850648 0.5303944270699019 0 1 0 1 K10208 0.0114285714285714 0.0227920227920227 crtM; 4,4'-diapophytoene synthase [EC:2.5.1.96] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 259.0 14.0 0.0 1.0 1.0 I 4.0 10.0 1.0 1.0 COG1562 Phytoene/squalene_synthetase ERG9 14.0 0.2857142857142857 0.7142857142857143 0.003196296859334 0.0127833598920022 0.0079898283756681 0.0095870630326682 0 0 0 0 K10209 0.0 0.0085470085470085 crtN; 4,4'-diapophytoene desaturase [EC:1.3.8.2] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 207.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 4.0 0.0 1.0 6.77174377500776e-13 0.0198569876757875 0.0099284938382323 0.0198569876751103 0 0 0 0 K10210 0.0 0.0227920227920227 crtP; diapolycopene oxygenase [EC:1.14.99.44] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 491.0 9.0 0.0 1.0 1.0 Q 0.0 9.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 9.0 0.0 1.0 0.0052632323587451 0.0168227307740363 0.0110429815663907 0.0115594984152912 0 0 0 0 K10211 0.0028571428571428 0.0284900284900284 crtQ; 4,4'-diaponeurosporenoate glycosyltransferase [EC:2.4.1.-] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 327.0 13.0 0.0 1.0 1.0 M 1.0 12.0 2.0 0.769230769230769 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 13.0 0.0769230769230769 0.9230769230769232 0.965650705848767 0.231542255092778 0.5985964804707725 0.734108450755989 0 0 1 1 K10212 0.0 0.017094017094017 K10212, crtO; glycosyl-4,4'-diaponeurosporenoate acyltransferase [EC:2.3.1.-] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 150.0 6.0 5.0 2.0 0.857142857142857 S 0.0 7.0 1.0 1.0 2E9V0 7.0 0.0 1.0 0.0215675222707944 0.0303406026061355 0.0259540624384649 0.0087730803353411 0 0 0 0 K10213 0.0057142857142857 0.0455840455840455 rihB; ribosylpyrimidine nucleosidase [EC:3.2.2.8] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 301.0 20.0 0.0 1.0 1.0 F 2.0 18.0 1.0 1.0 COG1957 Inosine-uridine_nucleoside_N-ribohydrolase URH1 20.0 0.1 0.9 0.608826558321404 0.427098014406756 0.51796228636408 0.181728543914648 0 0 0 1 K10215 0.0 0.0199430199430199 ethA; monooxygenase [EC:1.14.13.-] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 484.0 10.0 9.0 2.0 0.909090909090909 P 0.0 11.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 11.0 0.0 1.0 2.62655650100796e-05 0.0003126573549898 0.0001694614599999 0.0002863917899797 0 0 0 0 K10216 0.0142857142857142 0.0256410256410256 dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9] path:map00362,path:map00622,path:map00643,path:map01100,path:map01120,path:map01220 Benzoate degradation,Xylene degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 233.0 7.0 3.0 4.0 0.4375 E 5.0 11.0 3.0 0.4375 COG2021 Homoserine_O-acetyltransferase MET2 16.0 0.3125 0.6875 0.194505692433486 0.577743411633163 0.3861245520333245 0.383237719199677 0 0 0 0 K10217 0.0228571428571428 0.0911680911680911 dmpC, xylG, praB; aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85] path:map00362,path:map00380,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Tryptophan metabolism,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 450.0 48.0 0.0 1.0 1.0 C 8.0 40.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 48.0 0.1666666666666666 0.8333333333333334 0.0774090600080173 0.238182561900109 0.1577958109540631 0.1607735018920917 0 0 0 0 K10218 0.0228571428571428 0.1025641025641025 ligK, galC; 4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17] path:map00362,path:map00660,path:map01100,path:map01120 Benzoate degradation,C5-Branched dibasic acid metabolism,Metabolic pathways,Microbial metabolism in diverse environments 172.0 50.0 0.0 1.0 1.0 H 8.0 42.0 1.0 1.0 COG0684 RNA_degradosome_component_RraA_(regulator_of_RNase_E_activity) RraA 50.0 0.16 0.84 0.120738977247268 0.822266286756261 0.4715026320017645 0.701527309508993 0 0 0 0 K10219 0.0 0.0484330484330484 ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312] path:map00350,path:map00362,path:map00627,path:map01100,path:map01120,path:map01220 Tyrosine metabolism,Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 245.0 28.0 27.0 2.0 0.96551724137931 S 0.0 29.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 29.0 0.0 1.0 0.0070699314472872 0.0115981310267918 0.0093340312370395 0.0045281995795046 0 0 0 0 K10220 0.0057142857142857 0.037037037037037 ligJ; 4-oxalmesaconate hydratase [EC:4.2.1.83] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 288.0 15.0 0.0 1.0 1.0 S 2.0 13.0 1.0 1.0 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 15.0 0.1333333333333333 0.8666666666666667 0.0395131237322381 0.145930086066451 0.0927216048993445 0.1064169623342129 0 0 0 0 K10221 0.0 0.0284900284900284 ligI; 2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57] path:map00362,path:map00627,path:map01100,path:map01120 Benzoate degradation,Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 288.0 10.0 9.0 2.0 0.909090909090909 S 0.0 11.0 1.0 1.0 COG3618 Predicted_metal-dependent_hydrolase,_TIM-barrel_fold 11.0 0.0 1.0 0.0291257366331595 0.072145958236977 0.0506358474350682 0.0430202216038175 0 0 0 0 K10222 0.0028571428571428 0.0056980056980056 bphD; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase [EC:3.7.1.8] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 245.0 2.0 1.0 2.0 0.666666666666667 S 1.0 2.0 1.0 1.0 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K10227 0.0028571428571428 0.094017094017094 smoE, mtlE; polyol transport system substrate-binding protein path:map02010 ABC transporters 343.0 37.0 34.0 3.0 0.902439024390244 G 1.0 40.0 2.0 0.926829268292683 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 41.0 0.024390243902439 0.975609756097561 0.777424967461113 0.0606229223390778 0.4190239449000954 0.7168020451220352 0 0 1 1 K10228 0.0 0.0826210826210826 smoF, mtlF; polyol transport system permease protein path:map02010 ABC transporters 267.0 19.0 6.0 3.0 0.542857142857143 P 0.0 35.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 35.0 0.0 1.0 0.0055936226535884 0.0139194067177104 0.0097565146856494 0.008325784064122 0 0 0 0 K10229 0.0028571428571428 0.074074074074074 smoG, mtlG; polyol transport system permease protein path:map02010 ABC transporters 258.0 18.0 4.0 2.0 0.5625 G 3.0 29.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 32.0 0.09375 0.90625 0.0175537278799804 0.0301344085471222 0.0238440682135512 0.0125806806671418 0 0 0 0 K10231 0.02 0.0256410256410256 kojP; kojibiose phosphorylase [EC:2.4.1.230] 682.0 17.0 0.0 1.0 1.0 G 7.0 10.0 1.0 1.0 COG1554 Kojibiose_phosphorylase_YcjT ATH1 17.0 0.4117647058823529 0.5882352941176471 0.296287138860846 0.502127611398841 0.3992073751298435 0.2058404725379949 0 0 0 0 K10232 0.0 0.0911680911680911 aglE, ggtB; alpha-glucoside transport system substrate-binding protein path:map02010 ABC transporters 382.0 38.0 0.0 1.0 1.0 G 0.0 38.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 38.0 0.0 1.0 0.0277393463695656 0.764525091498276 0.3961322189339208 0.7367857451287103 0 0 0 0 K10233 0.0 0.0911680911680911 aglF, ggtC; alpha-glucoside transport system permease protein path:map02010 ABC transporters 252.0 28.0 17.0 3.0 0.682926829268293 P 0.0 41.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 41.0 0.0 1.0 0.178200883684522 0.836787589395701 0.5074942365401115 0.6585867057111789 0 0 0 0 K10234 0.0 0.1025641025641025 aglG, ggtD; alpha-glucoside transport system permease protein path:map02010 ABC transporters 253.0 21.0 6.0 3.0 0.538461538461538 P 0.0 39.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 39.0 0.0 1.0 0.169062088150983 0.883740521776449 0.526401304963716 0.714678433625466 0 0 0 0 K10235 0.0 0.0227920227920227 aglK; alpha-glucoside transport system ATP-binding protein path:map02010 ABC transporters 354.0 8.0 0.0 1.0 1.0 P 0.0 8.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 8.0 0.0 1.0 1.93860839415361e-12 3.1872680343921198e-12 2.562938214272865e-12 1.2486596402385101e-12 0 0 0 0 K10236 0.0057142857142857 0.0626780626780626 thuE, lpqY; trehalose/maltose transport system substrate-binding protein path:map02010 ABC transporters 323.0 35.0 0.0 1.0 1.0 G 3.0 32.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 35.0 0.0857142857142857 0.9142857142857144 0.596429649555277 0.488564001155208 0.5424968253552425 0.107865648400069 0 0 0 1 K10237 0.0085714285714285 0.0769230769230769 thuF, sugA; trehalose/maltose transport system permease protein path:map02010 ABC transporters 214.0 46.0 37.0 3.0 0.793103448275862 P 3.0 55.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 58.0 0.0517241379310344 0.9482758620689656 0.0081613843105031 0.937424857644018 0.4727931209772605 0.9292634733335148 0 0 0 0 K10238 0.0 0.0398860398860398 thuG, sugB; trehalose/maltose transport system permease protein path:map02010 ABC transporters 260.0 9.0 6.0 3.0 0.642857142857143 G 0.0 14.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 14.0 0.0 1.0 0.0312640657613339 0.051467254497391 0.0413656601293624 0.0202031887360571 0 0 0 0 K10240 0.0 0.0398860398860398 cebE; cellobiose transport system substrate-binding protein path:map02010 ABC transporters 386.0 25.0 0.0 1.0 1.0 G 0.0 25.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 25.0 0.0 1.0 0.0076230599863122 0.0072908595153631 0.0074569597508376 0.0003322004709491 0 0 0 0 K10241 0.0028571428571428 0.0712250712250712 cebF; cellobiose transport system permease protein path:map02010 ABC transporters 236.0 43.0 22.0 2.0 0.671875 P 1.0 63.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 64.0 0.015625 0.984375 0.0024223812690068 0.0051327444254511 0.0037775628472289 0.0027103631564443 0 0 0 0 K10242 0.0 0.0541310541310541 cebG; cellobiose transport system permease protein path:map02010 ABC transporters 257.0 22.0 10.0 2.0 0.647058823529412 G 0.0 34.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 34.0 0.0 1.0 0.0102370593721127 0.009693919555683 0.0099654894638978 0.0005431398164296 0 0 0 0 K10253 0.0 0.0341880341880341 DODA; DOPA 4,5-dioxygenase [EC:1.14.99.-] 107.0 15.0 0.0 1.0 1.0 Q 0.0 15.0 1.0 1.0 COG3805 Aromatic_ring-cleaving_dioxygenase DodA 15.0 0.0 1.0 0.0018483749063406 0.0059973129299636 0.0039228439181521 0.004148938023623 0 0 0 0 K10254 0.0257142857142857 0.0683760683760683 ohyA, sph; oleate hydratase [EC:4.2.1.53] 480.0 29.0 21.0 2.0 0.783783783783784 S 9.0 28.0 2.0 0.783783783783784 COG4716 Myosin-crossreactive_antigen__(function_unknown) 37.0 0.2432432432432432 0.7567567567567568 0.0276341083349353 0.0210093141529921 0.0243217112439637 0.0066247941819432 0 0 0 0 K10255 0.0 0.1424501424501424 FAD6, desA; acyl-lipid omega-6 desaturase (Delta-12 desaturase) [EC:1.14.19.23 1.14.19.45] path:map02020 Two-component system 215.0 58.0 54.0 2.0 0.935483870967742 I 0.0 62.0 2.0 0.935483870967742 COG3239 Fatty_acid_desaturase DesA 62.0 0.0 1.0 0.0015017655628634 0.0119852351752237 0.0067435003690435 0.0104834696123603 0 0 0 0 K10257 0.0 0.0256410256410256 FAD3, FAD7, FAD8, desB; acyl-lipid omega-3 desaturase [EC:1.14.19.25 1.14.19.35 1.14.19.36] 328.0 9.0 0.0 1.0 1.0 I 0.0 9.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 9.0 0.0 1.0 0.0008730606393727 0.0001170822067472 0.0004950714230599 0.0007559784326255 0 0 0 0 K10273 0.0 0.0028490028490028 FBXL7; F-box and leucine-rich repeat protein 7 123.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 KOG0498 1.0 0.0 1.0 0 0 0 0 K10277 0.0028571428571428 0.0113960113960113 KDM8, JMJD5; [protein]-arginine 3-hydroxylase / protease [EC:1.14.11.73 3.4.-.-] 237.0 3.0 1.0 4.0 0.428571428571429 P 1.0 6.0 2.0 0.857142857142857 COG2850 Ribosomal_protein_L16_Arg81_hydroxylase,_contains_JmjC_domain RoxA 7.0 0.1428571428571428 0.8571428571428571 0.0613209237033418 0.205108655445739 0.1332147895745404 0.1437877317423972 0 0 0 0 K10297 0.0 0.0284900284900284 FBXO11; F-box protein 11 102.0 9.0 8.0 3.0 0.818181818181818 G 0.0 11.0 4.0 0.727272727272727 COG4677 Pectin_methylesterase_and_related_acyl-CoA_thioesterases PemB 11.0 0.0 1.0 0.881894548063699 0.447638751753311 0.664766649908505 0.434255796310388 0 0 1 1 K10353 0.0057142857142857 0.0056980056980056 E2.7.1.76, dak; deoxyadenosine kinase [EC:2.7.1.76] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 180.0 4.0 0.0 1.0 1.0 F 2.0 2.0 1.0 1.0 COG1428 Deoxyadenosine/deoxycytidine_kinase Dck 4.0 0.5 0.5 0.87664720437016 0.814795153801571 0.8457211790858654 0.061852050568589 0 0 1 1 K10355 0.0314285714285714 0.0 ACTF; actin, other eukaryote 359.0 15.0 0.0 1.0 1.0 Z 15.0 0.0 1.0 1.0 COG5277 Actin-related_protein 15.0 1.0 0.0 0.938400670717021 0.999999623656436 0.9692001471867284 0.0615989529394149 0 0 1 1 K10368 0.0142857142857142 0.0 CAPG; capping protein (actin filament), gelsolin-like 193.0 5.0 0.0 1.0 1.0 Z 5.0 0.0 1.0 1.0 KOG0443 5.0 1.0 0.0 0.955728246753669 0.999999907361583 0.977864077057626 0.0442716606079139 0 0 1 1 K10380 0.0 0.0028490028490028 ANK; ankyrin path:map04624,path:map05205 Toll and Imd signaling pathway,Proteoglycans in cancer 1010.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K10389 0.0085714285714285 0.0 TUBG; tubulin gamma path:map05165 Human papillomavirus infection 457.0 3.0 0.0 1.0 1.0 Z 3.0 0.0 1.0 1.0 COG5023 Tubulin 3.0 1.0 0.0 0 0 0 0 K10402 0.0028571428571428 0.0 KIF20; kinesin family member 20 384.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0180 Tryptophanyl-tRNA_synthetase TrpS 1.0 1.0 0.0 0 0 0 0 K10419 0.04 0.0 DYNLRB, DNCL2; dynein light chain roadblock-type path:map05132 Salmonella infection 86.0 13.0 10.0 2.0 0.8125 DN 16.0 0.0 1.0 1.0 KOG4115 16.0 1.0 0.0 0.133161335848644 0.233118158714458 0.183139747281551 0.099956822865814 0 0 0 0 K10439 0.04 0.376068376068376 rbsB; ribose transport system substrate-binding protein path:map02010,path:map02030 ABC transporters,Bacterial chemotaxis 5.0 386.0 375.0 8.0 0.925659472422062 G 20.0 394.0 8.0 0.935251798561151 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 414.0 0.0483091787439613 0.9516908212560388 0.392101478343236 0.113221759451219 0.2526616188972275 0.278879718892017 0 0 0 0 K10440 0.0485714285714285 0.3333333333333333 rbsC; ribose transport system permease protein path:map02010 ABC transporters 154.0 338.0 305.0 5.0 0.822384428223844 G 29.0 382.0 5.0 0.914841849148418 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 411.0 0.0705596107055961 0.929440389294404 0.545637063202715 0.542659805501674 0.5441484343521945 0.0029772577010409 0 1 0 1 K10441 0.0171428571428571 0.3219373219373219 rbsA; ribose transport system ATP-binding protein [EC:7.5.2.7] path:map02010 ABC transporters 261.0 231.0 155.0 4.0 0.738019169329074 G 6.0 307.0 5.0 0.980830670926518 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 313.0 0.0191693290734824 0.9808306709265175 0.715118094824934 0.772024522493763 0.7435713086593485 0.0569064276688289 0 1 0 1 K10447 0.0 0.0028490028490028 KLHL9_13; kelch-like protein 9/13 path:map04120 Ubiquitin mediated proteolysis 628.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4441 1.0 0.0 1.0 0 0 0 0 K10467 0.0 0.0028490028490028 KLHL31; kelch-like protein 31 628.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4441 1.0 0.0 1.0 0 0 0 0 K10469 0.0 0.0028490028490028 KLHL34; kelch-like protein 34 413.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4441 1.0 0.0 1.0 0 0 0 0 K10475 0.0 0.0028490028490028 KBTBD8; kelch repeat and BTB domain-containing protein 8 141.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4441 1.0 0.0 1.0 0 0 0 0 K10530 0.0028571428571428 0.0256410256410256 lctO; L-lactate oxidase [EC:1.1.3.2] 360.0 10.0 0.0 1.0 1.0 C 1.0 9.0 1.0 1.0 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 10.0 0.1 0.9 0.0623488044557147 0.0861026772768425 0.0742257408662786 0.0237538728211277 0 0 0 0 K10531 0.0 0.0284900284900284 pvdA, SIDA; L-ornithine N5-monooxygenase [EC:1.14.13.195 1.14.13.196] 384.0 12.0 10.0 2.0 0.857142857142857 Q 0.0 14.0 2.0 0.928571428571429 COG3486 Lysine/ornithine_N-monooxygenase IucD 14.0 0.0 1.0 0.003416579883738 0.0059005188236953 0.0046585493537166 0.0024839389399572 0 0 0 0 K10533 0.0 0.0142450142450142 E3.3.2.8; limonene-1,2-epoxide hydrolase [EC:3.3.2.8] path:map00903,path:map01110 Limonene and pinene degradation,Biosynthesis of secondary metabolites 120.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 1.0 1.0 COG4308 Limonene-1,2-epoxide_hydrolase_LimA/EphG LimA 7.0 0.0 1.0 0.0012365735742361 0.0072277676833437 0.0042321706287899 0.0059911941091076 0 0 0 0 K10534 0.0028571428571428 0.0 NR; nitrate reductase (NAD(P)H) [EC:1.7.1.1 1.7.1.2 1.7.1.3] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 108.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 1.0 1.0 0.0 0 0 0 0 K10535 0.0028571428571428 0.0227920227920227 hao; hydroxylamine dehydrogenase [EC:1.7.2.6] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 265.0 6.0 2.0 2.0 0.6 C 1.0 9.0 2.0 0.8 COG3303 Formate-dependent_nitrite_reductase,_periplasmic_cytochrome_c552_subunit NrfA 10.0 0.1 0.9 0.0784011643388557 0.159663598459838 0.1190323813993468 0.0812624341209822 0 0 0 0 K10536 0.0457142857142857 0.2621082621082621 aguA; agmatine deiminase [EC:3.5.3.12] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 140.0 108.0 85.0 4.0 0.81203007518797 E 16.0 110.0 4.0 0.796992481203008 COG2957 Agmatine/peptidylarginine_deiminase AguA 126.0 0.1269841269841269 0.873015873015873 0.0320378204411606 0.386502563204665 0.2092701918229128 0.3544647427635043 0 0 0 0 K10537 0.0 0.0227920227920227 araF; L-arabinose transport system substrate-binding protein path:map02010 ABC transporters 300.0 8.0 0.0 1.0 1.0 G 0.0 8.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 8.0 0.0 1.0 0.101221851910202 0.194570369479633 0.1478961106949174 0.093348517569431 0 0 0 0 K10538 0.0 0.0256410256410256 araH; L-arabinose transport system permease protein path:map02010 ABC transporters 307.0 7.0 6.0 3.0 0.777777777777778 G 0.0 9.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 9.0 0.0 1.0 0.0746992667574115 0.178757431737374 0.1267283492473927 0.1040581649799625 0 0 0 0 K10539 0.0 0.0256410256410256 araG; L-arabinose transport system ATP-binding protein [EC:7.5.2.12] path:map02010 ABC transporters 454.0 5.0 1.0 2.0 0.555555555555556 G 0.0 9.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 9.0 0.0 1.0 8.24954262723651e-05 0.0008712587949694 0.0004768771106208 0.000788763368697 0 0 0 0 K10540 0.0 0.0598290598290598 mglB; methyl-galactoside transport system substrate-binding protein path:map02010,path:map02030 ABC transporters,Bacterial chemotaxis 283.0 46.0 0.0 1.0 1.0 G 0.0 46.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 46.0 0.0 1.0 0.0023243114349873 0.0086327838516069 0.0054785476432971 0.0063084724166195 0 0 0 0 K10541 0.0 0.0598290598290598 mglC; methyl-galactoside transport system permease protein path:map02010 ABC transporters 317.0 15.0 12.0 5.0 0.714285714285714 G 0.0 21.0 3.0 0.904761904761905 COG4211 ABC-type_glucose/galactose_transport_system,_permease_component MglC 21.0 0.0 1.0 0.013451975638415 0.180680723114613 0.097066349376514 0.167228747476198 0 0 0 0 K10542 0.0 0.0968660968660968 mglA; methyl-galactoside transport system ATP-binding protein [EC:7.5.2.11] path:map02010 ABC transporters 421.0 23.0 1.0 2.0 0.511111111111111 G 0.0 45.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 45.0 0.0 1.0 0.144235019773092 0.650954519958037 0.3975947698655645 0.5067195001849449 0 0 0 0 K10543 0.0 0.1139601139601139 xylF; D-xylose transport system substrate-binding protein path:map02010 ABC transporters 275.0 59.0 0.0 1.0 1.0 G 0.0 59.0 2.0 0.966101694915254 COG4213 ABC-type_xylose_transport_system,_periplasmic_component XylF 59.0 0.0 1.0 0.0213384758655489 0.653880186124604 0.3376093309950764 0.632541710259055 0 0 0 0 K10544 0.0 0.094017094017094 xylH; D-xylose transport system permease protein path:map02010 ABC transporters 338.0 39.0 37.0 2.0 0.951219512195122 G 0.0 41.0 1.0 1.0 COG4214 ABC-type_xylose_transport_system,_permease_component XylH 41.0 0.0 1.0 0.499496411564363 0.374392896764811 0.436944654164587 0.1251035147995519 0 0 0 0 K10545 0.0 0.1139601139601139 xylG; D-xylose transport system ATP-binding protein [EC:7.5.2.10] path:map02010 ABC transporters 195.0 42.0 25.0 2.0 0.711864406779661 G 0.0 59.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 59.0 0.0 1.0 0.010595898018912 0.174053122850313 0.0923245104346125 0.163457224831401 0 0 0 0 K10546 0.0 0.0968660968660968 chvE; putative multiple sugar transport system substrate-binding protein path:map02010 ABC transporters 315.0 46.0 0.0 1.0 1.0 G 0.0 46.0 1.0 1.0 COG4213 ABC-type_xylose_transport_system,_periplasmic_component XylF 46.0 0.0 1.0 0.0435027027979006 0.204050884630508 0.1237767937142043 0.1605481818326073 0 0 0 0 K10547 0.0 0.0968660968660968 gguB; putative multiple sugar transport system permease protein path:map02010 ABC transporters 366.0 38.0 36.0 3.0 0.926829268292683 G 0.0 41.0 1.0 1.0 COG4214 ABC-type_xylose_transport_system,_permease_component XylH 41.0 0.0 1.0 0.257699181941467 0.204493308897162 0.2310962454193145 0.053205873044305 0 0 0 0 K10548 0.0 0.1111111111111111 gguA; putative multiple sugar transport system ATP-binding protein [EC:7.5.2.-] path:map02010 ABC transporters 459.0 28.0 5.0 2.0 0.549019607843137 G 0.0 51.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 51.0 0.0 1.0 0.360132399069534 0.295679369716051 0.3279058843927925 0.0644530293534829 0 0 0 0 K10549 0.0 0.0142450142450142 alsB; D-allose transport system substrate-binding protein path:map02010 ABC transporters 283.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 5.0 0.0 1.0 0.130929588980555 0.229614430422191 0.180272009701373 0.098684841441636 0 0 0 0 K10550 0.0 0.0113960113960113 alsC; D-allose transport system permease protein path:map02010 ABC transporters 314.0 3.0 1.0 2.0 0.6 G 0.0 5.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 5.0 0.0 1.0 0.0780196314187742 0.152525292618555 0.1152724620186645 0.0745056611997807 0 0 0 0 K10551 0.0 0.0056980056980056 alsA; D-allose transport system ATP-binding protein [EC:7.5.2.8] path:map02010 ABC transporters 491.0 3.0 1.0 2.0 0.6 P 0.0 5.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 5.0 0.0 1.0 0.0068497690240145 3.38525365662165e-12 0.0034248845136998 0.0068497690206292 0 0 0 0 K10552 0.0 0.0712250712250712 frcB; fructose transport system substrate-binding protein path:map02010 ABC transporters 291.0 31.0 0.0 1.0 1.0 G 0.0 31.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 31.0 0.0 1.0 0.0184738873684952 0.0389753707228863 0.0287246290456907 0.0205014833543911 0 0 0 0 K10553 0.0 0.0569800569800569 frcC; fructose transport system permease protein path:map02010 ABC transporters 313.0 17.0 15.0 3.0 0.85 G 0.0 20.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 20.0 0.0 1.0 0.0388279087521012 0.0865306046920591 0.0626792567220801 0.0477026959399579 0 0 0 0 K10554 0.0 0.0541310541310541 frcA; fructose transport system ATP-binding protein path:map02010 ABC transporters 248.0 20.0 19.0 2.0 0.952380952380952 G 0.0 21.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 21.0 0.0 1.0 0.0333234043888973 0.100538064516715 0.0669307344528061 0.0672146601278177 0 0 0 0 K10555 0.0 0.0284900284900284 lsrB; AI-2 transport system substrate-binding protein path:map02010,path:map02024 ABC transporters,Quorum sensing 323.0 10.0 0.0 1.0 1.0 G 0.0 10.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 10.0 0.0 1.0 0.105092669474928 0.211157383501621 0.1581250264882745 0.106064714026693 0 0 0 0 K10556 0.0 0.037037037037037 lsrC; AI-2 transport system permease protein path:map02010,path:map02024 ABC transporters,Quorum sensing 320.0 9.0 5.0 3.0 0.642857142857143 G 0.0 14.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 14.0 0.0 1.0 0.0342839898273694 0.0862849209107163 0.0602844553690428 0.0520009310833468 0 0 0 0 K10557 0.0 0.0227920227920227 lsrD; AI-2 transport system permease protein path:map02010,path:map02024 ABC transporters,Quorum sensing 315.0 6.0 4.0 2.0 0.75 U 0.0 8.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 8.0 0.0 1.0 0.150190696481486 0.253208677086547 0.2016996867840165 0.1030179806050609 0 0 0 0 K10558 0.0 0.0142450142450142 lsrA, ego; AI-2 transport system ATP-binding protein path:map02010,path:map02024 ABC transporters,Quorum sensing 500.0 4.0 3.0 2.0 0.8 G 0.0 5.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 5.0 0.0 1.0 0.0964469493770016 0.197986386812763 0.1472166680948823 0.1015394374357614 0 0 0 0 K10559 0.0 0.074074074074074 rhaS; rhamnose transport system substrate-binding protein path:map02010 ABC transporters 297.0 29.0 0.0 1.0 1.0 G 0.0 29.0 2.0 0.96551724137931 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 29.0 0.0 1.0 0.509154106016296 0.565027818781453 0.5370909623988744 0.055873712765157 0 0 0 1 K10560 0.0 0.0655270655270655 rhaP; rhamnose transport system permease protein path:map02010 ABC transporters 316.0 19.0 17.0 3.0 0.826086956521739 G 0.0 23.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 23.0 0.0 1.0 0.826571565960744 0.793139797753824 0.809855681857284 0.0334317682069199 0 0 1 1 K10561 0.0 0.0655270655270655 rhaQ; rhamnose transport system permease protein path:map02010 ABC transporters 306.0 18.0 16.0 4.0 0.782608695652174 G 0.0 23.0 2.0 0.956521739130435 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 23.0 0.0 1.0 0.760052015440154 0.925498015686654 0.842775015563404 0.1654460002465 0 0 1 1 K10562 0.0 0.0655270655270655 rhaT; rhamnose transport system ATP-binding protein [EC:7.5.2.-] path:map02010 ABC transporters 483.0 18.0 13.0 2.0 0.782608695652174 G 0.0 23.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 23.0 0.0 1.0 0.898845414792458 0.929679164059858 0.914262289426158 0.0308337492673999 0 0 1 1 K10563 0.1142857142857142 0.6524216524216524 mutM, fpg; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] path:map03410 Base excision repair 94.0 334.0 327.0 3.0 0.968115942028986 L 49.0 296.0 3.0 0.968115942028986 COG0266 Formamidopyrimidine-DNA_glycosylase Nei 345.0 0.1420289855072463 0.8579710144927536 0.175646922431853 0.280999965666227 0.2283234440490399 0.1053530432343739 0 0 0 0 K10564 0.0 0.0113960113960113 motC; chemotaxis protein MotC path:map02040 Flagellar assembly 360.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2CAJ4 4.0 0.0 1.0 2.55965071954044e-12 3.66462424850392e-08 1.8324401067879372e-08 3.6643682834319656e-08 0 0 0 0 K10565 0.0 0.017094017094017 motD; chemotaxis protein MotD path:map02040 Flagellar assembly 330.0 6.0 5.0 2.0 0.857142857142857 N 0.0 7.0 2.0 0.857142857142857 COG3144 Flagellar_hook-length_control_protein_FliK FliK 7.0 0.0 1.0 0.0144892281789274 0.0175915675301594 0.0160403978545434 0.003102339351232 0 0 0 0 K10567 0.0 0.0028490028490028 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] path:map03410 Base excision repair 270.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2C50A 1.0 0.0 1.0 0 0 0 0 K10573 0.0085714285714285 0.0 UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] path:map04120 Ubiquitin mediated proteolysis 123.0 3.0 0.0 1.0 1.0 O 3.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 3.0 1.0 0.0 0 0 0 0 K10574 0.0028571428571428 0.0 UBE2B, RAD6B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] path:map04120 Ubiquitin mediated proteolysis 150.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 1.0 1.0 0.0 0 0 0 0 K10575 0.0 0.0028490028490028 UBE2G1, UBC7; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23] path:map04120,path:map04141,path:map05012,path:map05022 Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum,Parkinson disease,Pathways of neurodegeneration - multiple diseases 490.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K10576 0.0057142857142857 0.0 UBE2H, UBC8; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23] path:map04120 Ubiquitin mediated proteolysis 150.0 2.0 0.0 1.0 1.0 O 2.0 0.0 1.0 1.0 KOG0416 2.0 1.0 0.0 0 0 0 0 K10577 0.0028571428571428 0.0 UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I path:map03013,path:map04064,path:map04120,path:map05206 Nucleocytoplasmic transport,NF-kappa B signaling pathway,Ubiquitin mediated proteolysis,MicroRNAs in cancer 161.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 1.0 1.0 0.0 0 0 0 0 K10580 0.0085714285714285 0.0 UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] path:map04120,path:map04624,path:map05131 Ubiquitin mediated proteolysis,Toll and Imd signaling pathway,Shigellosis 146.0 3.0 0.0 1.0 1.0 O 3.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 3.0 1.0 0.0 0 0 0 0 K10616 0.0 0.0056980056980056 cymAa; p-cymene methyl-monooxygenase [EC:1.14.15.25] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 312.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 2.0 0.0 1.0 0 0 0 0 K10617 0.0 0.017094017094017 cymB; p-cumic alcohol dehydrogenase path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 246.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0138456293335798 0.0470860203622476 0.0304658248479137 0.0332403910286678 0 0 0 0 K10619 0.0 0.0085470085470085 cmtAb; p-cumate 2,3-dioxygenase subunit alpha [EC:1.14.12.25] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 373.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 4.0 0.0 1.0 3.61194793682682e-06 0.0001273081694304 6.54600586836134e-05 0.0001236962214935 0 0 0 0 K10620 0.0 0.0028490028490028 cmtB; 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [EC:1.3.1.58] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 248.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K10621 0.0028571428571428 0.0085470085470085 cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14] path:map00362,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 261.0 4.0 0.0 1.0 1.0 E 1.0 3.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 4.0 0.25 0.75 0.112508047081764 0.266719405744332 0.189613726413048 0.154211358662568 0 0 0 0 K10622 0.0 0.0028490028490028 cmtD, dhbB; HCOMODA/2-hydroxy-3-carboxy-muconic semialdehyde decarboxylase [EC:4.1.1.-] path:map00362,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 213.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 1.0 0.0 1.0 0 0 0 0 K10623 0.0028571428571428 0.0028490028490028 cmtE; HOMODA hydrolase [EC:3.7.1.-] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 257.0 1.0 0.0 2.0 0.5 S 1.0 1.0 1.0 1.0 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 2.0 0.5 0.5 0 0 0 0 K10666 0.0028571428571428 0.0 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27] path:map04141 Protein processing in endoplasmic reticulum 197.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG0039 Malate/lactate_dehydrogenase Mdh 1.0 1.0 0.0 0 0 0 0 K10670 0.0 0.0427350427350427 grdA; glycine/sarcosine/betaine reductase complex component A [EC:1.21.4.2 1.21.4.3 1.21.4.4] 38.0 24.0 2.0 2.0 0.521739130434783 C 0.0 46.0 2.0 0.630434782608696 2AE14 46.0 0.0 1.0 0.342751735950044 0.175300663293982 0.259026199622013 0.167451072656062 0 0 0 0 K10671 0.0 0.0427350427350427 grdE; glycine reductase complex component B subunit alpha and beta [EC:1.21.4.2] 426.0 20.0 0.0 1.0 1.0 C 0.0 20.0 1.0 1.0 28HF7 20.0 0.0 1.0 0.0213093988169305 0.175606012651625 0.0984577057342777 0.1542966138346945 0 0 0 0 K10672 0.0 0.0484330484330484 grdB; glycine reductase complex component B subunit gamma [EC:1.21.4.2] 55.0 41.0 36.0 2.0 0.891304347826087 S 0.0 46.0 2.0 0.804347826086957 COG1978 Predicted_RNase_H-related_nuclease_YkuK,_DUF458_family YkuK 46.0 0.0 1.0 0.035063883608143 0.0251856244444851 0.030124754026314 0.0098782591636578 0 0 0 0 K10673 0.0028571428571428 0.0056980056980056 "strA; streptomycin 3""-kinase [EC:2.7.1.87]" 212.0 3.0 0.0 1.0 1.0 J 1.0 2.0 1.0 1.0 COG3231 Aminoglycoside_phosphotransferase Aph 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K10674 0.0028571428571428 0.0826210826210826 ectD; ectoine hydroxylase [EC:1.14.11.55] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 92.0 57.0 56.0 2.0 0.982758620689655 Q 1.0 57.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 58.0 0.0172413793103448 0.9827586206896552 0.0004094502937055 0.0014456183594789 0.0009275343265922 0.0010361680657734 0 0 0 0 K10676 0.0 0.0199430199430199 tfdB; 2,4-dichlorophenol 6-monooxygenase [EC:1.14.13.20] path:map00361,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 578.0 7.0 0.0 1.0 1.0 CH 0.0 7.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 7.0 0.0 1.0 0.0852048059404401 0.14348864044197 0.114346723191205 0.0582838345015298 0 0 0 0 K10677 0.0 0.0028490028490028 E4.2.2.17; inulin fructotransferase (DFA-I-forming) [EC:4.2.2.17] 455.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2CBQ9 1.0 0.0 1.0 0 0 0 0 K10678 0.0057142857142857 0.0398860398860398 nfsA; nitroreductase [EC:1.-.-.-] path:map00633,path:map01120 Nitrotoluene degradation,Microbial metabolism in diverse environments 209.0 20.0 0.0 1.0 1.0 C 2.0 18.0 1.0 1.0 COG0778 Nitroreductase NfnB 20.0 0.1 0.9 0.152350723111485 0.34980790082575 0.2510793119686175 0.1974571777142649 0 0 0 0 K10679 0.0 0.0484330484330484 nfnB, nfsB; nitroreductase / dihydropteridine reductase [EC:1.-.-.- 1.5.1.34] path:map00633,path:map01120 Nitrotoluene degradation,Microbial metabolism in diverse environments 169.0 19.0 0.0 1.0 1.0 C 0.0 19.0 1.0 1.0 COG0778 Nitroreductase NfnB 19.0 0.0 1.0 0.109875407629778 0.0649178276907297 0.0873966176602538 0.0449575799390482 0 0 0 0 K10680 0.04 0.2421652421652421 nemA; N-ethylmaleimide reductase [EC:1.-.-.-] path:map00633,path:map01120 Nitrotoluene degradation,Microbial metabolism in diverse environments 261.0 120.0 119.0 3.0 0.983606557377049 C 16.0 106.0 3.0 0.983606557377049 COG1902 2,4-dienoyl-CoA_reductase_or_related_NADH-dependent_reductase,_Old_Yellow_Enzyme_(OYE)_family FadH 122.0 0.1311475409836065 0.8688524590163934 0.0674249616130531 0.108792855836457 0.088108908724755 0.0413678942234038 0 0 0 0 K10681 0.0 0.0284900284900284 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3] path:map02020 Two-component system 285.0 13.0 0.0 1.0 1.0 T 0.0 13.0 3.0 0.615384615384615 COG0642 Signal_transduction_histidine_kinase BaeS 13.0 0.0 1.0 0.377323406385217 0.484160699337763 0.43074205286149 0.106837292952546 0 0 0 0 K10682 0.0 0.0142450142450142 saeR; two-component system, OmpR family, response regulator SaeR path:map02020 Two-component system 123.0 2.0 0.0 3.0 0.4 K 0.0 5.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 5.0 0.0 1.0 0.0270299672369825 0.103008043986823 0.0650190056119027 0.0759780767498405 0 0 0 0 K10685 0.0057142857142857 0.0 UBLE1B, SAE2, UBA2; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45] path:map04120 Ubiquitin mediated proteolysis 510.0 2.0 0.0 1.0 1.0 O 2.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 2.0 1.0 0.0 0 0 0 0 K10686 0.0428571428571428 0.0 UBA3, UBE1C; NEDD8-activating enzyme E1 [EC:6.2.1.64] path:map04120 Ubiquitin mediated proteolysis 352.0 18.0 0.0 1.0 1.0 O 18.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 18.0 1.0 0.0 0.852460336993585 0.913522270003402 0.8829913034984935 0.0610619330098169 0 0 1 1 K10697 0.0 0.0455840455840455 rpaA; two-component system, OmpR family, response regulator RpaA path:map02020 Two-component system 234.0 8.0 1.0 3.0 0.470588235294118 K 0.0 17.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 17.0 0.0 1.0 0.0008849745020903 4.65118971749843e-06 0.0004448128459038 0.0008803233123728 0 0 0 0 K10699 0.0028571428571428 0.0 UBE1L2, UBA6; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45] path:map04120 Ubiquitin mediated proteolysis 527.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 1.0 1.0 0.0 0 0 0 0 K10700 0.0 0.0056980056980056 ebdA; ethylbenzene hydroxylase subunit alpha [EC:1.17.99.2] path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 1145.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 6.0 0.0 1.0 1.57165485539824e-12 2.400518568698e-12 1.98608671204812e-12 8.288637132997601e-13 0 0 0 0 K10708 0.0 0.0113960113960113 frlB; fructoselysine 6-phosphate deglycase [EC:3.5.-.-] 301.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG2222 Fructoselysine-6-P-deglycase_FrlB_or_related_protein,_duplicated_sugar_isomerase_(SIS)_domain AgaS 4.0 0.0 1.0 0.0692825729996121 0.156905796595142 0.113094184797377 0.0876232235955299 0 0 0 0 K10709 0.0 0.017094017094017 frlC; fructoselysine 3-epimerase [EC:5.1.3.41] 251.0 6.0 5.0 2.0 0.857142857142857 G 0.0 7.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 7.0 0.0 1.0 1.07106149037243e-11 0.133095605430063 0.0665478027203868 0.1330956054193523 0 0 0 0 K10710 0.0057142857142857 0.0341880341880341 frlD; fructoselysine 6-kinase [EC:2.7.1.218] 183.0 15.0 14.0 2.0 0.9375 G 2.0 14.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 16.0 0.125 0.875 0.0695943384029624 0.152020369276414 0.1108073538396882 0.0824260308734515 0 0 0 0 K10711 0.0 0.0284900284900284 frlR; GntR family transcriptional regulator, frlABCD operon transcriptional regulator 217.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 10.0 0.0 1.0 0.205324991711631 0.126042186528403 0.165683589120017 0.079282805183228 0 0 0 0 K10712 0.0 0.0028490028490028 ADO; cysteamine dioxygenase [EC:1.13.11.19] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 200.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2FJQG 1.0 0.0 1.0 0 0 0 0 K10713 0.0457142857142857 0.0256410256410256 fae; 5,6,7,8-tetrahydromethanopterin hydro-lyase [EC:4.2.1.147] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 162.0 12.0 2.0 3.0 0.444444444444444 C 17.0 10.0 2.0 0.62962962962963 COG0269 3-keto-L-gulonate-6-phosphate_decarboxylase UlaD 27.0 0.6296296296296297 0.3703703703703703 0.126178441689949 0.290831817849303 0.2085051297696259 0.164653376159354 0 0 0 0 K10714 0.0285714285714285 0.0256410256410256 mtdB; methylene-tetrahydromethanopterin dehydrogenase [EC:1.5.1.-] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 264.0 15.0 10.0 2.0 0.75 H 11.0 9.0 4.0 0.75 COG0373 Glutamyl-tRNA_reductase HemA 20.0 0.55 0.45 0.995618404355378 0.684935303034869 0.8402768536951235 0.3106831013205089 1 1 1 1 K10715 0.0028571428571428 0.0598290598290598 rpfC; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 25.0 26.0 0.0 1.0 1.0 T 1.0 25.0 5.0 0.538461538461538 COG0642 Signal_transduction_histidine_kinase BaeS 26.0 0.0384615384615384 0.9615384615384616 0.0160224588671969 0.0225285480083269 0.0192755034377619 0.00650608914113 0 0 0 0 K10716 0.4228571428571429 0.5185185185185185 kch, trkA, mthK, pch; voltage-gated potassium channel 18.0 434.0 384.0 8.0 0.790528233151184 P 244.0 295.0 17.0 0.698010849909584 COG1226 Voltage-gated_potassium_channel_Kch Kch 539.0 0.4526901669758812 0.5473098330241187 0.0053668466266723 0.0146082736002619 0.0099875601134671 0.0092414269735896 0 0 0 0 K10725 0.9457142857142856 0.0 cdc6A; archaeal cell division control protein 6 113.0 854.0 829.0 2.0 0.97155858930603 L 877.0 0.0 1.0 1.0 COG1474 Cdc6-related_protein,_AAA_superfamily_ATPase CDC6 877.0 1.0 0.0 0.488694680877257 0.0573132563453169 0.2730039686112869 0.43138142453194 0 0 0 0 K10726 0.94 0.0 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] path:map03030 DNA replication 285.0 422.0 398.0 4.0 0.933628318584071 L 452.0 0.0 6.0 0.898230088495575 COG1241 DNA_replicative_helicase_MCM_subunit_Mcm2,_Cdc46/Mcm_family Mcm2 452.0 1.0 0.0 0.192553448694068 0.987093475873347 0.5898234622837075 0.794540027179279 0 0 0 0 K10737 0.0028571428571428 0.0 MCM8; DNA helicase MCM8 [EC:5.6.2.4] 1136.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG1241 DNA_replicative_helicase_MCM_subunit_Mcm2,_Cdc46/Mcm_family Mcm2 1.0 1.0 0.0 0 0 0 0 K10742 0.2 0.1139601139601139 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] path:map03030 DNA replication 76.0 111.0 106.0 3.0 0.948717948717949 L 71.0 43.0 7.0 0.444444444444444 COG1112 Superfamily_I_DNA_and/or_RNA_helicase DNA2 114.0 0.6228070175438597 0.3771929824561403 0.28027836285397 0.799500053889984 0.5398892083719771 0.519221691036014 0 0 0 0 K10743 0.0 0.0056980056980056 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4] path:map03030 DNA replication 179.0 2.0 0.0 1.0 1.0 L 0.0 2.0 1.0 1.0 COG0164 Ribonuclease_HII RnhB 2.0 0.0 1.0 0 0 0 0 K10747 0.8828571428571429 0.301994301994302 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] path:map03030,path:map03410,path:map03420,path:map03430 DNA replication,Base excision repair,Nucleotide excision repair,Mismatch repair 204.0 489.0 461.0 4.0 0.926136363636364 L 400.0 128.0 3.0 0.950757575757576 COG1793 ATP-dependent_DNA_ligase CDC9 528.0 0.7575757575757576 0.2424242424242424 0.836025904531937 0.92163391736948 0.8788299109507085 0.0856080128375429 1 1 1 1 K10748 0.0 0.0085470085470085 tus, tau; DNA replication terminus site-binding protein 299.0 2.0 1.0 2.0 0.666666666666667 L 0.0 3.0 1.0 1.0 28I61 3.0 0.0 1.0 0 0 0 0 K10754 0.0028571428571428 0.0313390313390313 RFC1; replication factor C subunit 1 path:map03030,path:map03420,path:map03430 DNA replication,Nucleotide excision repair,Mismatch repair 648.0 12.0 0.0 1.0 1.0 L 1.0 11.0 2.0 0.916666666666667 COG0272 NAD-dependent_DNA_ligase Lig 12.0 0.0833333333333333 0.9166666666666666 0.0262158014342718 0.0528643219602707 0.0395400616972712 0.0266485205259989 0 0 0 0 K10756 0.0028571428571428 0.0 RFC3_5; replication factor C subunit 3/5 path:map03030,path:map03420,path:map03430 DNA replication,Nucleotide excision repair,Mismatch repair 347.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG0470 DNA_polymerase_III,_delta_prime_subunit HolB 1.0 1.0 0.0 0 0 0 0 K10762 0.0 0.0056980056980056 ydaV; putative replication protein 234.0 1.0 0.0 2.0 0.5 A 0.0 2.0 1.0 1.0 COG1484 DNA_replication_protein_DnaC DnaC 2.0 0.0 1.0 0 0 0 0 K10763 0.0 0.0797720797720797 hda; DnaA-homolog protein 193.0 27.0 26.0 2.0 0.964285714285714 L 0.0 28.0 1.0 1.0 COG0593 Chromosomal_replication_initiation_ATPase_DnaA DnaA 28.0 0.0 1.0 0.000347808656741 0.0126259762862009 0.0064868924714709 0.0122781676294599 0 0 0 0 K10764 0.0 0.2136752136752136 metZ; O-succinylhomoserine sulfhydrylase [EC:2.5.1.-] path:map00270,path:map00920,path:map01100 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways 351.0 79.0 0.0 1.0 1.0 E 0.0 79.0 2.0 0.822784810126582 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 79.0 0.0 1.0 0.0031184105025192 0.0160821747017962 0.0096002926021576 0.0129637641992769 0 0 0 0 K10770 0.0285714285714285 0.0 ALKBH8, TRM9; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229] 181.0 6.0 2.0 2.0 0.6 A 10.0 0.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 10.0 1.0 0.0 0.136714784147188 0.000526423028935 0.0686206035880614 0.136188361118253 0 0 0 0 K10773 0.8885714285714286 0.9116809116809116 NTH; endonuclease III [EC:4.2.99.18] path:map03410 Base excision repair 74.0 800.0 793.0 5.0 0.97442143727162 L 415.0 406.0 5.0 0.952496954933009 COG0177 Endonuclease_III Nth 821.0 0.5054811205846529 0.4945188794153471 0.566304177649826 0.0992467155055983 0.3327754465777121 0.4670574621442277 0 1 0 1 K10774 0.0 0.0398860398860398 E4.3.1.23; tyrosine ammonia-lyase [EC:4.3.1.23] path:map00350,path:map01100 Tyrosine metabolism,Metabolic pathways 464.0 14.0 13.0 2.0 0.933333333333333 E 0.0 15.0 1.0 1.0 COG2986 Histidine_ammonia-lyase HutH 15.0 0.0 1.0 0.115901035132064 0.254306362011399 0.1851036985717315 0.138405326879335 0 0 0 0 K10775 0.0 0.0256410256410256 PAL; phenylalanine ammonia-lyase [EC:4.3.1.24] path:map00360,path:map00940,path:map01100,path:map01110 Phenylalanine metabolism,Phenylpropanoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 508.0 9.0 8.0 2.0 0.9 E 0.0 10.0 1.0 1.0 COG2986 Histidine_ammonia-lyase HutH 10.0 0.0 1.0 0.0545918619217891 0.256078912238945 0.155335387080367 0.2014870503171559 0 0 0 0 K10778 0.0971428571428571 0.3504273504273504 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] 82.0 102.0 64.0 7.0 0.520408163265306 L 37.0 157.0 5.0 0.938775510204082 COG0350 DNA_repair_enzyme_Ada_(O6-methylguanine-DNA--protein-cysteine_methyltransferase) AdaB 194.0 0.190721649484536 0.8092783505154639 0.031845519783911 0.140868473361858 0.0863569965728845 0.109022953577947 0 0 0 0 K10780 0.0 0.0341880341880341 fabL; enoyl-[acyl-carrier protein] reductase III [EC:1.3.1.104] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 233.0 10.0 5.0 2.0 0.666666666666667 IQ 0.0 15.0 2.0 0.666666666666667 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 15.0 0.0 1.0 0.0133677151997829 0.0693491862906034 0.0413584507451931 0.0559814710908204 0 0 0 0 K10793 0.0 0.0313390313390313 prdA; D-proline reductase (dithiol) PrdA [EC:1.21.4.1] path:map00330,path:map00470,path:map01100 Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways 247.0 17.0 15.0 2.0 0.894736842105263 EJ 0.0 18.0 2.0 0.578947368421053 COG0252 L-asparaginase/archaeal_Glu-tRNAGln_amidotransferase_subunit_D AnsA 18.0 0.0 1.0 0.0286131529203126 0.0603055680107842 0.0444593604655483 0.0316924150904716 0 0 0 0 K10794 0.0 0.0427350427350427 prdB; D-proline reductase (dithiol) PrdB [EC:1.21.4.1] path:map00330,path:map00470,path:map01100 Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways 144.0 17.0 16.0 2.0 0.944444444444444 S 0.0 18.0 2.0 0.833333333333333 COG1978 Predicted_RNase_H-related_nuclease_YkuK,_DUF458_family YkuK 18.0 0.0 1.0 0.0105156614945632 0.0225014025657911 0.0165085320301771 0.0119857410712279 0 0 0 0 K10795 0.0 0.017094017094017 prdD; D-proline reductase (dithiol)-stabilizing protein PrdD 252.0 4.0 2.0 2.0 0.666666666666667 EJ 0.0 6.0 1.0 1.0 COG5275 BRCT_domain_type_II 6.0 0.0 1.0 0.0784837422128159 0.101865959402413 0.0901748508076144 0.0233822171895971 0 0 0 0 K10796 0.0 0.017094017094017 prdE; D-proline reductase (dithiol)-stabilizing protein PrdE 155.0 6.0 0.0 1.0 1.0 EJ 0.0 6.0 1.0 1.0 COG0252 L-asparaginase/archaeal_Glu-tRNAGln_amidotransferase_subunit_D AnsA 6.0 0.0 1.0 0.0362180505379166 0.0816392189989881 0.0589286347684523 0.0454211684610715 0 0 0 0 K10797 0.0028571428571428 0.0398860398860398 enr; 2-enoate reductase [EC:1.3.1.31] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 483.0 22.0 0.0 1.0 1.0 C 1.0 21.0 3.0 0.863636363636364 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 22.0 0.0454545454545454 0.9545454545454546 0.0338461856501976 0.0491765864943599 0.0415113860722787 0.0153304008441623 0 0 0 0 K10798 0.0114285714285714 0.017094017094017 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] path:map03410,path:map04210,path:map04212 Base excision repair,Apoptosis,Longevity regulating pathway - worm 130.0 5.0 3.0 3.0 0.625 S 4.0 6.0 3.0 0.7 COG3831 WGR_domain,_predicted_DNA-binding_domain_in_MolR WGR 10.0 0.4 0.6 0.110817758702193 0.323070237355512 0.2169439980288525 0.2122524786533189 0 0 0 0 K10799 0.0 0.0028490028490028 TNKS; tankyrase [EC:2.4.2.30] 281.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 2.0 0.0 1.0 0 0 0 0 K10800 0.0342857142857142 0.0341880341880341 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] path:map03410 Base excision repair 202.0 23.0 21.0 2.0 0.92 L 13.0 12.0 2.0 0.92 COG1573 Uracil-DNA_glycosylase Udg4 25.0 0.52 0.48 0.0235634991505525 0.0601773929986543 0.0418704460746034 0.0366138938481018 0 0 0 0 K10804 0.0028571428571428 0.2649572649572649 tesA; acyl-CoA thioesterase I [EC:3.1.2.- 3.1.2.2 3.1.1.2 3.1.1.5] path:map01040 Biosynthesis of unsaturated fatty acids 76.0 104.0 101.0 2.0 0.97196261682243 E 1.0 106.0 4.0 0.953271028037383 COG2755 Lysophospholipase_L1_or_related_esterase._Includes_spore_coat_protein_LipC/YcsK TesA 107.0 0.0093457943925233 0.9906542056074766 0.0145542131444806 0.147655678084328 0.0811049456144043 0.1331014649398474 0 0 0 0 K10805 0.0 0.1481481481481481 tesB; acyl-CoA thioesterase II [EC:3.1.2.-] path:map01040 Biosynthesis of unsaturated fatty acids 181.0 69.0 0.0 1.0 1.0 I 0.0 69.0 1.0 1.0 COG1946 Acyl-CoA_thioesterase TesB 69.0 0.0 1.0 0.0006302377707477 0.0026196399770185 0.0016249388738831 0.0019894022062708 0 0 0 0 K10806 0.0057142857142857 0.1481481481481481 yciA; acyl-CoA thioesterase YciA [EC:3.1.2.-] path:map01040 Biosynthesis of unsaturated fatty acids 109.0 62.0 0.0 1.0 1.0 I 2.0 60.0 1.0 1.0 COG1607 Acyl-CoA_hydrolase YciA 62.0 0.032258064516129 0.967741935483871 0.003246894907435 0.0098893294025131 0.006568112154974 0.006642434495078 0 0 0 0 K10810 0.0 0.017094017094017 tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 200.0 6.0 0.0 1.0 1.0 H 0.0 6.0 1.0 1.0 COG0352 Thiamine_monophosphate_synthase ThiE 6.0 0.0 1.0 0.0134666459945472 0.0321499130521529 0.02280827952335 0.0186832670576057 0 0 0 0 K10811 0.0 0.0056980056980056 E2.5.1.2; thiamine pyridinylase [EC:2.5.1.2] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 384.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 2.0 0.0 1.0 0 0 0 0 K10814 0.0 0.0085470085470085 hcnA; hydrogen cyanide synthase HcnA [EC:1.4.99.5] path:map00460,path:map01100,path:map01110 Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 831.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 3.0 0.0 1.0 0 0 0 0 K10815 0.0 0.0085470085470085 hcnB; hydrogen cyanide synthase HcnB [EC:1.4.99.5] path:map00460,path:map01100,path:map01110 Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 270.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 3.0 0.0 1.0 0 0 0 0 K10816 0.0 0.0028490028490028 hcnC; hydrogen cyanide synthase HcnC [EC:1.4.99.5] path:map00460,path:map01100,path:map01110 Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 417.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 1.0 0.0 1.0 0 0 0 0 K10817 0.0 0.0142450142450142 eryAI; 6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 61.0 3.0 2.0 3.0 0.6 GM 0.0 5.0 3.0 0.6 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 5.0 0.0 1.0 0.047902148086218 0.132711392960367 0.0903067705232925 0.084809244874149 0 0 0 0 K10819 0.0028571428571428 0.0598290598290598 E2.7.13.3; histidine kinase [EC:2.7.13.3] 241.0 24.0 0.0 1.0 1.0 T 1.0 23.0 8.0 0.291666666666667 COG0642 Signal_transduction_histidine_kinase BaeS 24.0 0.0416666666666666 0.9583333333333334 0.285573613459725 0.696813044057272 0.4911933287584984 0.411239430597547 0 0 0 0 K10820 0.0 0.0142450142450142 ytfR; galactofuranose transport system ATP-binding protein [EC:7.5.2.9] path:map02010 ABC transporters 348.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG4213 ABC-type_xylose_transport_system,_periplasmic_component XylF 5.0 0.0 1.0 0.211893618048847 0.170072926826306 0.1909832724375765 0.0418206912225409 0 0 0 0 K10822 0.0 0.0028490028490028 E7.4.2.2; nonpolar-amino-acid-transporting ATPase [EC:7.4.2.2] 256.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0411 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivG LivG 1.0 0.0 1.0 0 0 0 0 K10823 0.1742857142857143 0.4757834757834758 oppF; oligopeptide transport system ATP-binding protein path:map01501,path:map02010,path:map02024 beta-Lactam resistance,ABC transporters,Quorum sensing 180.0 272.0 115.0 2.0 0.634032634032634 P 86.0 342.0 3.0 0.946386946386946 COG4608 ABC-type_oligopeptide_transport_system,_ATPase_component AppF 428.0 0.2009345794392523 0.7990654205607477 0.965126136732684 0.974780362432501 0.9699532495825924 0.0096542256998169 1 1 1 1 K10824 0.0314285714285714 0.0712250712250712 nikE, cntF; nickel transport system ATP-binding protein [EC:7.2.2.11] path:map02010 ABC transporters 202.0 33.0 27.0 3.0 0.785714285714286 P 11.0 31.0 3.0 0.595238095238095 COG4608 ABC-type_oligopeptide_transport_system,_ATPase_component AppF 42.0 0.2619047619047619 0.7380952380952381 0.954417722317563 0.802892617886211 0.878655170101887 0.151525104431352 1 1 1 1 K10826 0.0 0.0028490028490028 214.0 1.0 0.0 1.0 1.0 EP 0.0 1.0 1.0 1.0 COG1124 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppF 1.0 0.0 1.0 0 0 0 0 K10830 0.0 0.0085470085470085 psaB, scaC, sloA; manganese/zinc transport system ATP-binding protein [EC:7.2.2.5] path:map02010 ABC transporters 234.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 4.0 0.0 1.0 7.4145535096793115e-09 6.43334488044298e-06 3.2203797169763294e-06 6.4259303269333006e-06 0 0 0 0 K10831 0.0028571428571428 0.0997150997150997 tauB; taurine transport system ATP-binding protein [EC:7.6.2.7] path:map00920,path:map02010 Sulfur metabolism,ABC transporters 200.0 40.0 0.0 1.0 1.0 P 1.0 39.0 2.0 0.75 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 40.0 0.025 0.975 0.0570113598472713 0.595538559789094 0.3262749598181826 0.5385271999418226 0 0 0 0 K10834 0.0 0.0427350427350427 hmuV, phuV, bhuV, hemV; heme transport system ATP-binding protein [EC:7.6.2.5] 522.0 12.0 10.0 3.0 0.75 S 0.0 16.0 2.0 0.875 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 16.0 0.0 1.0 0.0307261554279277 0.0229252595955924 0.02682570751176 0.0078008958323352 0 0 0 0 K10837 0.0514285714285714 0.0 PSTK; O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164] path:map00450,path:map00970 Selenocompound metabolism,Aminoacyl-tRNA biosynthesis 208.0 19.0 0.0 1.0 1.0 F 19.0 0.0 1.0 1.0 COG4088 tRNA_uridine_5-carbamoylmethylation_protein_Kti12_(Killer_toxin_insensitivity_protein) Kti12 19.0 1.0 0.0 0.0529516003486636 0.0467372786733319 0.0498444395109977 0.0062143216753317 0 0 0 0 K10843 0.2142857142857142 0.1082621082621082 ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:5.6.2.4] path:map03022,path:map03420 Basal transcription factors,Nucleotide excision repair 333.0 66.0 17.0 6.0 0.523809523809524 K 85.0 41.0 4.0 0.896825396825397 COG1061 Superfamily_II_DNA_or_RNA_helicase SSL2 126.0 0.6746031746031746 0.3253968253968254 0.0011109657373474 0.0037142692767278 0.0024126175070376 0.0026033035393804 0 0 0 0 K10844 0.66 0.0512820512820512 ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:5.6.2.3] path:map03022,path:map03420 Basal transcription factors,Nucleotide excision repair 134.0 275.0 238.0 4.0 0.78125 L 333.0 19.0 4.0 0.980113636363636 COG1199 Rad3-related_DNA_helicase_DinG DinG 352.0 0.9460227272727272 0.0539772727272727 0.966533729325954 0.974549695384098 0.970541712355026 0.0080159660581439 1 1 1 1 K10848 0.2142857142857142 0.0028490028490028 ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-] path:map03420,path:map03460 Nucleotide excision repair,Fanconi anemia pathway 133.0 83.0 0.0 1.0 1.0 L 82.0 1.0 2.0 0.963855421686747 COG1948 ERCC4-type_crossover_junction_endonuclease MUS81 83.0 0.9879518072289156 0.0120481927710843 0.02482637042827 0.0710690189864962 0.0479476947073831 0.0462426485582262 0 0 0 0 K10850 0.0 0.0085470085470085 narT; MFS transporter, NNP family, putative nitrate transporter path:map02020 Two-component system 187.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG2223 Nitrate/nitrite_transporter_NarK NarK 3.0 0.0 1.0 0 0 0 0 K10851 0.0 0.017094017094017 nreA; nitrogen regulatory protein A path:map02020 Two-component system 133.0 6.0 0.0 1.0 1.0 T 0.0 6.0 3.0 0.5 COG2203 GAF_domain GAF 6.0 0.0 1.0 0.0303073868710805 0.0835129358827351 0.0569101613769078 0.0532055490116546 0 0 0 0 K10854 0.0085714285714285 0.0142450142450142 acxB; acetone carboxylase, alpha subunit [EC:6.4.1.6] 715.0 10.0 0.0 1.0 1.0 EQ 3.0 7.0 1.0 1.0 COG0146 N-methylhydantoinase_B/oxoprolinase/acetone_carboxylase,_alpha_subunit HyuB 10.0 0.3 0.7 0.0208235091819881 0.0554309027120403 0.0381272059470142 0.0346073935300522 0 0 0 0 K10855 0.0 0.017094017094017 acxA; acetone carboxylase, beta subunit [EC:6.4.1.6] 477.0 8.0 0.0 1.0 1.0 EQ 0.0 8.0 1.0 1.0 COG0145 N-methylhydantoinase_A/oxoprolinase/acetone_carboxylase,_beta_subunit HyuA 8.0 0.0 1.0 0.0193358550327988 0.0499563358567287 0.0346460954447637 0.0306204808239299 0 0 0 0 K10856 0.0057142857142857 0.0142450142450142 acxC; acetone carboxylase, gamma subunit [EC:6.4.1.6] 163.0 10.0 0.0 1.0 1.0 Q 2.0 8.0 1.0 1.0 COG4647 Acetone_carboxylase,_gamma_subunit AcxC 10.0 0.2 0.8 0.0030201325325897 0.0087676274868469 0.0058938800097183 0.0057474949542572 0 0 0 0 K10857 0.0 0.0341880341880341 exoX; exodeoxyribonuclease X [EC:3.1.11.-] path:map03430 Mismatch repair 135.0 14.0 0.0 1.0 1.0 L 0.0 14.0 2.0 0.928571428571429 COG0847 DNA_polymerase_III,_epsilon_subunit_or_related_3'-5'_exonuclease DnaQ 14.0 0.0 1.0 0.0958741522607134 0.496905158705289 0.2963896554830012 0.4010310064445756 0 0 0 0 K10865 0.0314285714285714 0.0 MRE11; double-strand break repair protein MRE11 path:map03440,path:map03450,path:map04218 Homologous recombination,Non-homologous end-joining,Cellular senescence 396.0 11.0 0.0 1.0 1.0 L 11.0 0.0 1.0 1.0 COG0420 DNA_repair_exonuclease_SbcCD_nuclease_subunit SbcD 11.0 1.0 0.0 0.889287400688312 0.987397180412363 0.9383422905503376 0.098109779724051 0 0 1 1 K10866 0.0057142857142857 0.0 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] path:map03440,path:map03450,path:map04218 Homologous recombination,Non-homologous end-joining,Cellular senescence 259.0 2.0 0.0 1.0 1.0 L 2.0 0.0 1.0 1.0 COG0419 DNA_repair_exonuclease_SbcCD_ATPase_subunit SbcC 2.0 1.0 0.0 0 0 0 0 K10871 0.0028571428571428 0.0 RAD51L3, RAD51D; RAD51-like protein 3 path:map03440 Homologous recombination 233.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 1.0 1.0 0.0 0 0 0 0 K10872 0.0142857142857142 0.0 DMC1; meiotic recombination protein DMC1 path:map04113 Meiosis - yeast 225.0 5.0 0.0 1.0 1.0 L 5.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 5.0 1.0 0.0 0.0852740144587296 0.806793772377296 0.4460338934180128 0.7215197579185664 0 0 0 0 K10878 0.04 0.0028490028490028 SPO11; meiotic recombination protein SPO11 path:map04113 Meiosis - yeast 375.0 16.0 0.0 1.0 1.0 L 15.0 1.0 3.0 0.875 COG1697 DNA_topoisomerase_VI,_subunit_A Spo11 16.0 0.9375 0.0625 0.02961204511226 0.550921448600973 0.2902667468566165 0.521309403488713 0 0 0 0 K10896 0.8057142857142857 0.0028490028490028 FANCM; fanconi anemia group M protein path:map03460 Fanconi anemia pathway 321.0 390.0 0.0 1.0 1.0 L 325.0 1.0 3.0 0.98974358974359 COG1111 ERCC4-related_helicase MPH1 326.0 0.9969325153374232 0.0030674846625766 0.975733221381128 0.91802011721238 0.946876669296754 0.0577131041687479 0 0 1 1 K10906 0.0085714285714285 0.0142450142450142 recE; exodeoxyribonuclease VIII [EC:3.1.11.-] 157.0 8.0 0.0 1.0 1.0 L 3.0 5.0 2.0 0.625 COG0847 DNA_polymerase_III,_epsilon_subunit_or_related_3'-5'_exonuclease DnaQ 8.0 0.375 0.625 0.233518362383311 0.484041717672514 0.3587800400279125 0.250523355289203 0 0 0 0 K10907 0.4942857142857143 0.3162393162393162 K10907; aminotransferase [EC:2.6.1.-] 251.0 348.0 341.0 2.0 0.980281690140845 E 200.0 155.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 355.0 0.5633802816901409 0.4366197183098591 0.217792032157647 0.989197826411601 0.603494929284624 0.7714057942539541 0 0 0 0 K10909 0.0 0.0256410256410256 luxQ; two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:2.7.13.3 3.1.3.-] path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 373.0 15.0 0.0 1.0 1.0 T 0.0 15.0 4.0 0.466666666666667 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 15.0 0.0 1.0 0.0028974306268309 0.008945214759538 0.0059213226931844 0.0060477841327071 0 0 0 0 K10910 0.0 0.0142450142450142 luxP; autoinducer 2-binding periplasmic protein LuxP path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 360.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 5.0 0.0 1.0 0.130581059388657 0.243669689252828 0.1871253743207425 0.113088629864171 0 0 0 0 K10911 0.0 0.0056980056980056 luxU; two-component system, phosphorelay protein LuxU path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 68.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG2198 HPt_(histidine-containing_phosphotransfer)_domain HPtr 3.0 0.0 1.0 0 0 0 0 K10912 0.0 0.0341880341880341 luxO; two-component system, repressor protein LuxO path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 415.0 14.0 0.0 1.0 1.0 T 0.0 14.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 14.0 0.0 1.0 0.002903742681493 0.0055962557173689 0.0042499991994309 0.0026925130358759 0 0 0 0 K10913 0.0 0.0028490028490028 hapR, luxR, litR; TetR/AcrR family transcriptional regulator, hemagglutinin/protease regulatory protein path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 201.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K10914 0.0114285714285714 0.5527065527065527 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein path:map02020,path:map02024,path:map02025,path:map02026,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa,Biofilm formation - Escherichia coli,Biofilm formation - Vibrio cholerae 16.0 231.0 55.0 6.0 0.560679611650485 K 5.0 405.0 3.0 0.987864077669903 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 410.0 0.0121951219512195 0.9878048780487804 0.0133009213193524 0.2800489826786 0.1466749519989762 0.2667480613592476 0 0 0 0 K10915 0.0 0.0028490028490028 cqsA; CAI-1 autoinducer synthase [EC:2.3.-.-] path:map02024,path:map05111 Quorum sensing,Biofilm formation - Vibrio cholerae 428.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 1.0 0.0 1.0 0 0 0 0 K10916 0.0 0.0199430199430199 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-] path:map02020,path:map02024,path:map05111 Two-component system,Quorum sensing,Biofilm formation - Vibrio cholerae 114.0 9.0 0.0 1.0 1.0 T 0.0 9.0 3.0 0.555555555555556 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 9.0 0.0 1.0 0.0046723018460898 0.0121146653398518 0.0083934835929708 0.007442363493762 0 0 0 0 K10917 0.0 0.0113960113960113 aphA; PadR family transcriptional regulator, regulatory protein AphA path:map02024,path:map05111 Quorum sensing,Biofilm formation - Vibrio cholerae 98.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1695 DNA-binding_transcriptional_regulator,_PadR_family PadR 4.0 0.0 1.0 0.0349591148459489 0.0875467751332528 0.0612529449896008 0.0525876602873039 0 0 0 0 K10918 0.0 0.0113960113960113 aphB; LysR family transcriptional regulator, transcriptional activator AphB path:map05111 Biofilm formation - Vibrio cholerae 282.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.0298752552092554 0.0619758788908254 0.0459255670500404 0.03210062368157 0 0 0 0 K10920 0.0 0.0028490028490028 tcpP; toxin coregulated pilus biosynthesis protein P path:map05111 Biofilm formation - Vibrio cholerae 203.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG3710 DNA-binding_winged_helix-turn-helix_(wHTH)_domain CadC1 1.0 0.0 1.0 0 0 0 0 K10921 0.0 0.0056980056980056 toxR; cholera toxin transcriptional activator path:map05111 Biofilm formation - Vibrio cholerae 204.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG3710 DNA-binding_winged_helix-turn-helix_(wHTH)_domain CadC1 2.0 0.0 1.0 0 0 0 0 K10922 0.0 0.0028490028490028 toxS; transmembrane regulatory protein ToxS path:map05111 Biofilm formation - Vibrio cholerae 181.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2AVZE 1.0 0.0 1.0 0 0 0 0 K10923 0.0 0.0056980056980056 tcpN, toxT; AraC family transcriptional regulator, TCP pilus virulence regulatory protein path:map05111 Biofilm formation - Vibrio cholerae 177.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 2.0 0.0 1.0 0 0 0 0 K10924 0.0 0.0569800569800569 mshA; MSHA pilin protein MshA path:map05111 Biofilm formation - Vibrio cholerae 60.0 25.0 23.0 2.0 0.925925925925926 NU 0.0 27.0 3.0 0.888888888888889 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 27.0 0.0 1.0 0.753941827786983 0.10510700758825 0.4295244176876165 0.6488348201987331 0 0 1 1 K10925 0.0 0.017094017094017 mshB; MSHA pilin protein MshB path:map05111 Biofilm formation - Vibrio cholerae 112.0 7.0 0.0 1.0 1.0 NU 0.0 7.0 3.0 0.428571428571429 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 7.0 0.0 1.0 0.101500624077873 0.157767620679984 0.1296341223789285 0.056266996602111 0 0 0 0 K10926 0.0028571428571428 0.0997150997150997 mshC; MSHA pilin protein MshC path:map05111 Biofilm formation - Vibrio cholerae 23.0 41.0 0.0 1.0 1.0 NU 1.0 40.0 4.0 0.414634146341463 COG4968 Type_IV_pilus_assembly_protein_PilE PilE 41.0 0.024390243902439 0.975609756097561 0.745745465094922 0.580731573732719 0.6632385194138205 0.165013891362203 0 0 0 1 K10927 0.0 0.0683760683760683 mshD; MSHA pilin protein MshD path:map05111 Biofilm formation - Vibrio cholerae 62.0 26.0 0.0 1.0 1.0 NU 0.0 26.0 3.0 0.5 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 26.0 0.0 1.0 0.192381347553904 0.255040538043204 0.2237109427985539 0.0626591904892999 0 0 0 0 K10930 0.0028571428571428 0.017094017094017 tcpA; toxin coregulated pilin path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 49.0 7.0 0.0 1.0 1.0 NU 1.0 6.0 2.0 0.857142857142857 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 7.0 0.1428571428571428 0.8571428571428571 0.159687167666249 0.337446433269843 0.248566800468046 0.177759265603594 0 0 0 0 K10931 0.0028571428571428 0.017094017094017 tcpB; toxin coregulated pilus biosynthesis protein B path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 67.0 6.0 0.0 1.0 1.0 NU 1.0 6.0 3.0 0.714285714285714 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 7.0 0.1428571428571428 0.8571428571428571 0.159134835120568 0.3387205164134 0.248927675766984 0.179585681292832 0 0 0 0 K10932 0.0 0.0056980056980056 tcpC; toxin coregulated pilus biosynthesis outer membrane protein C path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 383.0 1.0 0.0 2.0 0.5 M 0.0 2.0 1.0 1.0 COG4796 Type_II_secretory_pathway,_component_HofQ HofQ 2.0 0.0 1.0 0 0 0 0 K10933 0.0 0.0028490028490028 tcpD; toxin coregulated pilus biosynthesis protein D path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 259.0 0.0 1.0 1.0 1.0 2AX1K 1.0 0.0 1.0 0 0 0 0 K10934 0.0 0.0056980056980056 tcpE; toxin coregulated pilus biosynthesis protein E path:map05110,path:map05111 Vibrio cholerae infection,Biofilm formation - Vibrio cholerae 309.0 2.0 0.0 1.0 1.0 U 0.0 2.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 2.0 0.0 1.0 0 0 0 0 K10936 0.0 0.0113960113960113 acfA; accessory colonization factor AcfA path:map05111 Biofilm formation - Vibrio cholerae 158.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 5.0 0.0 1.0 0.0613218137706595 0.111373078093278 0.0863474459319687 0.0500512643226185 0 0 0 0 K10937 0.0028571428571428 0.0 acfB; accessory colonization factor AcfB path:map05111 Biofilm formation - Vibrio cholerae 696.0 2.0 0.0 1.0 1.0 NT 2.0 0.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 2.0 1.0 0.0 0 0 0 0 K10938 0.0 0.0142450142450142 acfC; accessory colonization factor AcfC path:map05111 Biofilm formation - Vibrio cholerae 221.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG4588 Accessory_colonization_factor_AcfC,_contains_ABC-type_periplasmic_domain AcfC 5.0 0.0 1.0 0.0761408710055729 0.165241805676865 0.1206913383412189 0.0891009346712921 0 0 0 0 K10939 0.0 0.0113960113960113 acfD; accessory colonization factor AcfD path:map05111 Biofilm formation - Vibrio cholerae 481.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3064 Membrane_protein_TolA_involved_in_colicin_uptake TolA 4.0 0.0 1.0 0.0367922232614507 0.156295158979636 0.0965436911205433 0.1195029357181853 0 0 0 0 K10941 0.0 0.094017094017094 flrA, fleQ, flaK; sigma-54 dependent transcriptional regulator, flagellar regulatory protein path:map02020,path:map02025,path:map02040,path:map05111 Two-component system,Biofilm formation - Pseudomonas aeruginosa,Flagellar assembly,Biofilm formation - Vibrio cholerae 245.0 25.0 12.0 3.0 0.581395348837209 T 0.0 43.0 3.0 0.744186046511628 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 43.0 0.0 1.0 0.002319038212546 0.013827817897498 0.008073428055022 0.011508779684952 0 0 0 0 K10942 0.0 0.0883190883190883 flrB, fleS, flaL; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] path:map02020,path:map05111 Two-component system,Biofilm formation - Vibrio cholerae 210.0 35.0 34.0 2.0 0.972222222222222 T 0.0 36.0 6.0 0.333333333333333 COG5000 Signal_transduction_histidine_kinase_NtrY_involved_in_nitrogen_fixation_and_metabolism_regulation NtrY 36.0 0.0 1.0 0.0029217519059336 0.0435209447638468 0.0232213483348901 0.0405991928579132 0 0 0 0 K10943 0.0 0.1766381766381766 flrC, fleR, flaM; two-component system, response regulator FlrC path:map02020,path:map02040,path:map05111 Two-component system,Flagellar assembly,Biofilm formation - Vibrio cholerae 315.0 65.0 63.0 4.0 0.928571428571429 T 0.0 70.0 2.0 0.942857142857143 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 70.0 0.0 1.0 0.260114204021649 0.411416177327174 0.3357651906744114 0.151301973305525 0 0 0 0 K10944 0.0342857142857142 0.0028490028490028 pmoA-amoA; methane/ammonia monooxygenase subunit A [EC:1.14.18.3 1.14.99.39] path:map00680,path:map00910,path:map01100,path:map01120,path:map01200 Methane metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 202.0 16.0 0.0 1.0 1.0 C 12.0 4.0 2.0 0.75 arCOG08676 16.0 0.75 0.25 9.11286254616246e-13 1.4279633879256699e-12 1.169624821270958e-12 5.166771333094242e-13 0 0 0 0 K10945 0.0342857142857142 0.0028490028490028 pmoB-amoB; methane/ammonia monooxygenase subunit B path:map00680,path:map00910,path:map01100,path:map01120,path:map01200 Methane metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 178.0 14.0 13.0 2.0 0.933333333333333 C 12.0 3.0 2.0 0.8 arCOG08675 15.0 0.8 0.2 3.22394511158907e-06 0.0029592887881939 0.0014812563666527 0.0029560648430823 0 0 0 0 K10946 0.0342857142857142 0.0028490028490028 pmoC-amoC; methane/ammonia monooxygenase subunit C path:map00680,path:map00910,path:map01100,path:map01120,path:map01200 Methane metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 185.0 26.0 0.0 1.0 1.0 C 21.0 5.0 1.0 1.0 arCOG08699 26.0 0.8076923076923077 0.1923076923076923 0.0009796679589315 0.0019323854973887 0.0014560267281601 0.0009527175384571 0 0 0 0 K10947 0.1857142857142857 0.2678062678062678 padR; PadR family transcriptional regulator, regulatory protein PadR 27.0 222.0 213.0 3.0 0.936708860759494 K 79.0 158.0 3.0 0.936708860759494 COG1695 DNA-binding_transcriptional_regulator,_PadR_family PadR 237.0 0.3333333333333333 0.6666666666666666 0.0032438451194477 0.124616028630077 0.0639299368747623 0.1213721835106293 0 0 0 0 K10952 0.0 0.0028490028490028 ace; accessory cholera enterotoxin path:map05110 Vibrio cholerae infection 94.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2AXRZ 1.0 0.0 1.0 0 0 0 0 K10953 0.0 0.0199430199430199 rtxA; RTX toxin RtxA path:map05110 Vibrio cholerae infection 76.0 3.0 2.0 5.0 0.428571428571429 Q 0.0 7.0 6.0 0.285714285714286 COG1511 Uncharacterized_membrane_protein_YhgE,_phage_infection_protein_(PIP)_family YhgE 7.0 0.0 1.0 0.820711720982445 0.052408249469139 0.436559985225792 0.768303471513306 0 0 1 1 K10954 0.0 0.0199430199430199 zot; zona occludens toxin path:map05110 Vibrio cholerae infection 224.0 6.0 3.0 3.0 0.6 S 0.0 10.0 3.0 0.6 COG4128 Zona_occludens_toxin,_predicted_ATPase Zot 10.0 0.0 1.0 0.0234594365901446 0.0548522602670626 0.0391558484286036 0.031392823676918 0 0 0 0 K10956 0.0371428571428571 0.0 SEC61A; protein transport protein SEC61 subunit alpha path:map03060,path:map04141,path:map04145,path:map05110 Protein export,Protein processing in endoplasmic reticulum,Phagosome,Vibrio cholerae infection 448.0 9.0 4.0 2.0 0.642857142857143 U 14.0 0.0 1.0 1.0 COG0201 Preprotein_translocase_subunit_SecY SecY 14.0 1.0 0.0 0.0308953260296419 0.36342235387601 0.1971588399528259 0.3325270278463681 0 0 0 0 K10960 0.1028571428571428 0.1424501424501424 chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111] path:map00860,path:map00900,path:map01100,path:map01110 Porphyrin metabolism,Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 179.0 91.0 90.0 2.0 0.989130434782608 C 39.0 53.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 92.0 0.4239130434782608 0.5760869565217391 0.0564599064466757 0.419955334301058 0.2382076203738668 0.3634954278543823 0 0 0 0 K10961 0.0 0.0028490028490028 tcpI; toxin coregulated pilus biosynthesis protein I path:map05111 Biofilm formation - Vibrio cholerae 620.0 1.0 0.0 1.0 1.0 NT 0.0 1.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 1.0 0.0 1.0 0 0 0 0 K10962 0.0 0.0028490028490028 tcpQ; toxin coregulated pilus biosynthesis protein Q path:map05111 Biofilm formation - Vibrio cholerae 170.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 2AX19 1.0 0.0 1.0 0 0 0 0 K10964 0.0 0.0028490028490028 tcpS; toxin coregulated pilus biosynthesis protein S path:map05111 Biofilm formation - Vibrio cholerae 149.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2BAW2 1.0 0.0 1.0 0 0 0 0 K10965 0.0 0.0056980056980056 tcpT; toxin coregulated pilus biosynthesis protein T path:map05111 Biofilm formation - Vibrio cholerae 421.0 2.0 0.0 1.0 1.0 NU 0.0 2.0 1.0 1.0 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 2.0 0.0 1.0 0 0 0 0 K10966 0.0 0.037037037037037 tcpJ; toxin coregulated pilus biosynthesis protein J [EC:3.4.23.43 2.1.1.-] 224.0 13.0 0.0 1.0 1.0 NOU 0.0 13.0 1.0 1.0 COG1989 Prepilin_signal_peptidase_PulO_(type_II_secretory_pathway)_or_related_peptidase PulO 13.0 0.0 1.0 0 0 0 0 K10967 0.0028571428571428 0.0 KTR1_3; alpha 1,2-mannosyltransferase [EC:2.4.1.-] path:map00514 Other types of O-glycan biosynthesis 300.0 1.0 0.0 1.0 1.0 G 1.0 0.0 1.0 1.0 COG5020 1.0 1.0 0.0 0 0 0 0 K10972 0.0 0.0085470085470085 allS; LysR family transcriptional regulator, transcriptional activator of the allD operon 294.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 3.0 0.0 1.0 0 0 0 0 K10973 0.0 0.0056980056980056 allR; IclR family transcriptional regulator, negative regulator of allantoin and glyoxylate utilization operons 266.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 2.0 0.0 1.0 0 0 0 0 K10974 0.0428571428571428 0.0512820512820512 codB; cytosine permease 337.0 43.0 0.0 1.0 1.0 F 16.0 27.0 1.0 1.0 COG1457 Purine-cytosine_permease_or_related_protein CodB 43.0 0.3720930232558139 0.627906976744186 0.111568265062547 0.124695597648779 0.118131931355663 0.0131273325862319 0 0 0 0 K10975 0.0 0.017094017094017 allP; allantoin permease 463.0 6.0 0.0 1.0 1.0 FH 0.0 6.0 1.0 1.0 COG1953 Cytosine/uracil/thiamine/allantoin_permease FUI1 6.0 0.0 1.0 0.175744007028445 0.305711487131233 0.240727747079839 0.1299674801027879 0 0 0 0 K10977 0.16 0.0028490028490028 aksA; methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-] path:map00300,path:map00620,path:map00680,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230,path:map01240 Lysine biosynthesis,Pyruvate metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 323.0 35.0 8.0 2.0 0.564516129032258 H 61.0 1.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 62.0 0.9838709677419356 0.0161290322580645 0.89199729457512 0.984977785246215 0.9384875399106676 0.092980490671095 0 0 1 1 K10978 0.1428571428571428 0.0056980056980056 aksF; methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-] path:map00300,path:map00680,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230,path:map01240 Lysine biosynthesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 273.0 62.0 0.0 1.0 1.0 C 60.0 2.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 62.0 0.967741935483871 0.032258064516129 0.666499465060994 0.238441933258304 0.452470699159649 0.42805753180269 0 0 0 1 K10979 0.0628571428571428 0.188034188034188 ku; DNA end-binding protein Ku path:map03450 Non-homologous end-joining 210.0 100.0 99.0 2.0 0.99009900990099 L 22.0 79.0 1.0 1.0 COG1273 Non-homologous_end_joining_protein_Ku,_dsDNA_break_repair YkoV 101.0 0.2178217821782178 0.7821782178217822 0.123980723185425 0.0388704488763649 0.0814255860308949 0.0851102743090601 0 0 0 0 K10984 0.0 0.0085470085470085 agaB; galactosamine PTS system EIIB component [EC:2.7.1.-] path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 154.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG3444 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_component_IIB AgaB 4.0 0.0 1.0 5.95109425446308e-12 0.0844144078469536 0.0422072039264523 0.0844144078410025 0 0 0 0 K10985 0.0 0.0113960113960113 agaC; galactosamine PTS system EIIC component path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 255.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 4.0 0.0 1.0 0.130106019517795 0.240393269443227 0.185249644480511 0.110287249925432 0 0 0 0 K10986 0.0 0.0113960113960113 agaD; galactosamine PTS system EIID component path:map00052,path:map01100,path:map02060 Galactose metabolism,Metabolic pathways,Phosphotransferase system (PTS) 251.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 6.0 0.0 1.0 4.92351301657095e-12 0.0386055320845167 0.0193027660447201 0.0386055320795931 0 0 0 0 K11003 0.0 0.037037037037037 hlyD, cyaD; membrane fusion protein, hemolysin D path:map03070,path:map05133 Bacterial secretion system,Pertussis 413.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 15.0 0.0 1.0 0.0115827941579312 0.0534980399157114 0.0325404170368213 0.0419152457577802 0 0 0 0 K11004 0.0028571428571428 0.0455840455840455 hlyB, cyaB; ATP-binding cassette, subfamily B, bacterial HlyB/CyaB path:map02010,path:map03070,path:map05133 ABC transporters,Bacterial secretion system,Pertussis 630.0 24.0 0.0 1.0 1.0 V 1.0 23.0 1.0 1.0 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 24.0 0.0416666666666666 0.9583333333333334 0.0069152382606603 0.0276933762632407 0.0173043072619505 0.0207781380025804 0 0 0 0 K11005 0.0028571428571428 0.0113960113960113 hlyA; hemolysin A 103.0 3.0 1.0 3.0 0.5 Q 1.0 5.0 2.0 0.833333333333333 COG2931 Ca2+-binding_protein,_RTX_toxin-related 6.0 0.1666666666666666 0.8333333333333334 0.0083812463895575 0.0270679770744601 0.0177246117320088 0.0186867306849026 0 0 0 0 K11013 0.0 0.0028490028490028 cdtA; cytolethal distending toxin subunit A 226.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 2BZ78 2.0 0.0 1.0 0 0 0 0 K11014 0.0028571428571428 0.0056980056980056 cdtB; cytolethal distending toxin subunit B path:map05132 Salmonella infection 202.0 4.0 0.0 1.0 1.0 S 1.0 3.0 1.0 1.0 COG3021 Uncharacterized_conserved_protein_YafD,_endonuclease/exonuclease/phosphatase_(EEP)_superfamily YafD 4.0 0.25 0.75 4.19755210538153e-12 0.0854287938562895 0.0427143969302435 0.0854287938520919 0 0 0 0 K11015 0.0 0.0028490028490028 cdtC; cytolethal distending toxin subunit C 176.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2BH91 2.0 0.0 1.0 0 0 0 0 K11016 0.0 0.0227920227920227 shlA, hhdA, hpmA; hemolysin path:map03070 Bacterial secretion system 6.0 10.0 8.0 3.0 0.769230769230769 U 0.0 11.0 3.0 0.615384615384615 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 11.0 0.0 1.0 0.0422011759751879 0.0600802809580323 0.0511407284666101 0.0178791049828443 0 0 0 0 K11017 0.0 0.0 shlB, hhdB, hpmB; hemolysin activation/secretion protein path:map03070 Bacterial secretion system 5.0 0.0 1.0 1.0 U 0.0 0.0 1.0 1.0 COG2831 Hemolysin_activation/secretion_protein FhaC 0.0 0 0 0 0 K11021 0.02 0.0455840455840455 tccC; insecticidal toxin complex protein TccC 83.0 17.0 7.0 3.0 0.607142857142857 P 7.0 21.0 3.0 0.607142857142857 COG0428 Zinc_transporter_ZupT ZupT 28.0 0.25 0.75 0.0342969294460243 0.130064916015909 0.0821809227309666 0.0957679865698847 0 0 0 0 K11022 0.0 0.0227920227920227 rtxA1, rtxA; structural toxin protein (hemagglutinin/hemolysin) RtxA path:map05134 Legionellosis 103.0 7.0 6.0 2.0 0.875 S 0.0 8.0 1.0 1.0 COG3323 PII-like_insert_in_the_uncharacterized_protein_YqfO,_YbgI/NIF3_family YqfO 8.0 0.0 1.0 0.0275388767103605 0.0504135738378445 0.0389762252741025 0.022874697127484 0 0 0 0 K11031 0.0 0.0113960113960113 slo; thiol-activated cytolysin path:map02024 Quorum sensing 428.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 28HH2 4.0 0.0 1.0 0.024802344832607 0.0525065607375471 0.038654452785077 0.0277042159049401 0 0 0 0 K11033 0.0 0.0028490028490028 nheA; non-hemolytic enterotoxin A path:map02024 Quorum sensing 411.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0466 ATP-dependent_Lon_protease,_bacterial_type Lon 1.0 0.0 1.0 0 0 0 0 K11034 0.0 0.0028490028490028 nheBC; non-hemolytic enterotoxin B/C path:map02024 Quorum sensing 411.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0466 ATP-dependent_Lon_protease,_bacterial_type Lon 1.0 0.0 1.0 0 0 0 0 K11041 0.0285714285714285 0.0341880341880341 eta; exfoliative toxin A/B path:map05150 Staphylococcus aureus infection 244.0 22.0 0.0 1.0 1.0 P 10.0 12.0 1.0 1.0 COG1275 Tellurite_resistance_protein_TehA_and_related_permeases TehA 22.0 0.4545454545454545 0.5454545454545454 0.0281910303476915 0.103955965144019 0.0660734977458552 0.0757649347963275 0 0 0 0 K11045 0.0 0.0028490028490028 cfa; cAMP factor 204.0 3.0 2.0 2.0 0.75 N 0.0 4.0 2.0 0.75 COG5492 Uncharacterized_conserved_protein_YjdB,_contains_Ig-like_domain YjdB 4.0 0.0 1.0 2.34143403414357e-12 2.14762645821853e-17 1.170727755204076e-12 2.341412557878988e-12 0 0 0 0 K11050 0.0228571428571428 0.0256410256410256 cylA; multidrug/hemolysin transport system ATP-binding protein path:map02010 ABC transporters 237.0 20.0 0.0 1.0 1.0 V 8.0 12.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 20.0 0.4 0.6 0.0972522630874359 0.12826123003404 0.1127567465607379 0.0310089669466041 0 0 0 0 K11051 0.0057142857142857 0.0142450142450142 cylB; multidrug/hemolysin transport system permease protein path:map02010 ABC transporters 270.0 7.0 6.0 2.0 0.875 V 3.0 5.0 1.0 1.0 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 8.0 0.375 0.625 0.422596458798292 0.117026911779448 0.26981168528887 0.305569547018844 0 0 0 0 K11055 0.0 0.0056980056980056 cylJ; CylJ protein 286.0 2.0 0.0 1.0 1.0 CG 0.0 2.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 2.0 0.0 1.0 0 0 0 0 K11059 0.0 0.0056980056980056 entA; probable enterotoxin A 166.0 2.0 0.0 1.0 1.0 N 0.0 2.0 2.0 0.5 COG5492 Uncharacterized_conserved_protein_YjdB,_contains_Ig-like_domain YjdB 2.0 0.0 1.0 0 0 0 0 K11060 0.0 0.0341880341880341 entB; probable enterotoxin B 120.0 10.0 6.0 2.0 0.714285714285714 S 0.0 14.0 2.0 0.714285714285714 COG3807 SH3-like_domain SH3 14.0 0.0 1.0 0.0152486271680741 0.0489837919102686 0.0321162095391713 0.0337351647421945 0 0 0 0 K11062 0.0 0.0313390313390313 entD; probable enterotoxin D 60.0 10.0 4.0 2.0 0.625 S 0.0 16.0 4.0 0.625 COG3807 SH3-like_domain SH3 16.0 0.0 1.0 0.0127928364986649 0.0313528965244805 0.0220728665115726 0.0185600600258156 0 0 0 0 K11063 0.0 0.0028490028490028 tcdAB; toxin A/B path:map02024 Quorum sensing 2186.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 1.0 0.0 1.0 0 0 0 0 K11065 0.0 0.3447293447293447 tpx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24] 149.0 129.0 0.0 1.0 1.0 O 0.0 129.0 1.0 1.0 COG2077 Peroxiredoxin Tpx 129.0 0.0 1.0 0.0087195906689759 0.0361479720396109 0.0224337813542934 0.0274283813706349 0 0 0 0 K11066 0.0028571428571428 0.1082621082621082 E3.5.1.28D, amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 90.0 48.0 47.0 2.0 0.979591836734694 V 1.0 48.0 1.0 1.0 COG3023 N-acetyl-anhydromuramyl-L-alanine_amidase_AmpD AmpD 49.0 0.0204081632653061 0.979591836734694 0.0049113948667035 0.0714666813348112 0.0381890381007573 0.0665552864681077 0 0 0 0 K11068 0.0114285714285714 0.4017094017094017 hlyIII; hemolysin III 147.0 156.0 151.0 2.0 0.968944099378882 S 4.0 158.0 2.0 0.993827160493827 COG1272 Predicted_membrane_channel-forming_protein_YqfA,_hemolysin_III_family YqfA 162.0 0.0246913580246913 0.9753086419753086 0.0201369907002371 0.258570081737181 0.139353536218709 0.2384330910369438 0 0 0 0 K11069 0.0857142857142857 0.2962962962962963 potD; spermidine/putrescine transport system substrate-binding protein path:map02010 ABC transporters 68.0 170.0 114.0 2.0 0.752212389380531 E 52.0 172.0 3.0 0.942477876106195 COG0687 Spermidine/putrescine-binding_periplasmic_protein PotD 224.0 0.2321428571428571 0.7678571428571429 0.0033215998746624 0.474296910507535 0.2388092551910987 0.4709753106328725 0 0 0 0 K11070 0.0771428571428571 0.2877492877492877 potC; spermidine/putrescine transport system permease protein path:map02010 ABC transporters 158.0 103.0 21.0 4.0 0.525510204081633 P 43.0 153.0 4.0 0.913265306122449 COG1177 ABC-type_spermidine/putrescine_transport_system,_permease_component_II PotC 196.0 0.2193877551020408 0.7806122448979592 0.0090270550650998 0.347735137544075 0.1783810963045874 0.3387080824789751 0 0 0 0 K11071 0.0857142857142857 0.2962962962962963 potB; spermidine/putrescine transport system permease protein path:map02010 ABC transporters 181.0 138.0 81.0 3.0 0.696969696969697 P 47.0 151.0 2.0 0.98989898989899 COG1176 ABC-type_spermidine/putrescine_transport_system,_permease_component_I PotB 198.0 0.2373737373737373 0.7626262626262627 0.0043846533842285 0.0060572394105709 0.0052209463973997 0.0016725860263423 0 0 0 0 K11072 0.1485714285714285 0.3561253561253561 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] path:map02010 ABC transporters 219.0 125.0 4.0 3.0 0.494071146245059 P 71.0 182.0 4.0 0.75098814229249 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 253.0 0.2806324110671936 0.7193675889328063 0.24870620179976 0.521486342400349 0.3850962721000545 0.2727801406005889 0 0 0 0 K11073 0.0142857142857142 0.0911680911680911 potF, spuD, spuE; putrescine transport system substrate-binding protein path:map02010 ABC transporters 332.0 26.0 6.0 2.0 0.565217391304348 E 5.0 41.0 1.0 1.0 COG0687 Spermidine/putrescine-binding_periplasmic_protein PotD 46.0 0.108695652173913 0.8913043478260869 0.0030632008994273 0.0084062191247644 0.0057347100120958 0.005343018225337 0 0 0 0 K11074 0.0 0.0997150997150997 potI, spuH; putrescine transport system permease protein path:map02010 ABC transporters 253.0 22.0 8.0 2.0 0.611111111111111 E 0.0 36.0 1.0 1.0 COG1177 ABC-type_spermidine/putrescine_transport_system,_permease_component_II PotC 36.0 0.0 1.0 0.0153072625860964 0.0282011108818039 0.0217541867339501 0.0128938482957075 0 0 0 0 K11075 0.0 0.0854700854700854 potH, spuG; putrescine transport system permease protein path:map02010 ABC transporters 268.0 19.0 7.0 2.0 0.612903225806452 P 1.0 30.0 1.0 1.0 COG1176 ABC-type_spermidine/putrescine_transport_system,_permease_component_I PotB 31.0 0.032258064516129 0.967741935483871 0.011357490445459 0.0291088036126843 0.0202331470290716 0.0177513131672253 0 0 0 0 K11076 0.0057142857142857 0.1225071225071225 potG, spuF; putrescine transport system ATP-binding protein [EC:7.6.2.16] path:map02010 ABC transporters 286.0 30.0 7.0 2.0 0.566037735849057 P 2.0 51.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 53.0 0.0377358490566037 0.9622641509433962 0.0061205744703313 0.0162605507406237 0.0111905626054774 0.0101399762702924 0 0 0 0 K11077 0.0 0.0056980056980056 attC; mannopine transport system substrate-binding protein path:map02010 ABC transporters 335.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0687 Spermidine/putrescine-binding_periplasmic_protein PotD 2.0 0.0 1.0 0 0 0 0 K11080 0.0 0.0085470085470085 attA1; mannopine transport system ATP-binding protein path:map02010 ABC transporters 227.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 3.0 0.0 1.0 0 0 0 0 K11081 0.0 0.0199430199430199 phnS; 2-aminoethylphosphonate transport system substrate-binding protein path:map02010 ABC transporters 304.0 7.0 0.0 1.0 1.0 P 0.0 7.0 1.0 1.0 COG1840 ABC-type_Fe3+_transport_system,_periplasmic_component AfuA 7.0 0.0 1.0 0.0852990101961387 0.174405411526625 0.1298522108613818 0.0891064013304863 0 0 0 0 K11082 0.0 0.0056980056980056 phnV; 2-aminoethylphosphonate transport system permease protein path:map02010 ABC transporters 265.0 1.0 0.0 2.0 0.5 P 0.0 2.0 1.0 1.0 COG1177 ABC-type_spermidine/putrescine_transport_system,_permease_component_II PotC 2.0 0.0 1.0 0 0 0 0 K11083 0.0 0.0056980056980056 phnU; 2-aminoethylphosphonate transport system permease protein path:map02010 ABC transporters 285.0 1.0 0.0 2.0 0.5 P 0.0 2.0 1.0 1.0 COG0555 ABC-type_sulfate_transport_system,_permease_component CysU 2.0 0.0 1.0 0 0 0 0 K11084 0.0 0.0113960113960113 phnT; 2-aminoethylphosphonate transport system ATP-binding protein path:map02010 ABC transporters 339.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 4.0 0.0 1.0 0.0720198726633135 0.223822673431511 0.1479212730474122 0.1518028007681975 0 0 0 0 K11085 0.1657142857142857 0.6809116809116809 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6] path:map02010 ABC transporters 252.0 371.0 282.0 2.0 0.806521739130435 V 99.0 361.0 2.0 0.98695652173913 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 460.0 0.2152173913043478 0.7847826086956522 0.793015903603165 0.87371609963192 0.8333660016175425 0.080700196028755 1 1 1 1 K11089 0.0 0.0427350427350427 TROVE2, SSA2; 60 kDa SS-A/Ro ribonucleoprotein path:map05322 Systemic lupus erythematosus 444.0 12.0 7.0 2.0 0.705882352941176 S 0.0 17.0 2.0 0.647058823529412 COG2425 Uncharacterized_conserved_protein,_contains_a_von_Willebrand_factor_type_A_(vWA)_domain ViaA 17.0 0.0 1.0 0.0533633240733455 0.131234474346792 0.0922988992100687 0.0778711502734465 0 0 0 0 K11102 0.0 0.1168091168091168 gltP, gltT; proton glutamate symport protein 347.0 30.0 13.0 2.0 0.638297872340426 C 0.0 47.0 2.0 0.978723404255319 COG1301 Na+/H+-dicarboxylate_symporter GltP 47.0 0.0 1.0 0.0173774839565531 0.0587968818414041 0.0380871828989786 0.041419397884851 0 0 0 0 K11103 0.0 0.1566951566951566 dctA; aerobic C4-dicarboxylate transport protein path:map02020 Two-component system 356.0 46.0 24.0 3.0 0.647887323943662 C 0.0 71.0 1.0 1.0 COG1301 Na+/H+-dicarboxylate_symporter GltP 71.0 0.0 1.0 0.0615938410566781 0.0956422299419424 0.0786180354993102 0.0340483888852642 0 0 0 0 K11104 0.0 0.0284900284900284 melB; melibiose permease 417.0 15.0 14.0 2.0 0.9375 G 0.0 16.0 2.0 0.9375 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 16.0 0.0 1.0 0.0109571129695295 0.0228507367479251 0.0169039248587273 0.0118936237783956 0 0 0 0 K11105 0.2314285714285714 0.282051282051282 cvrA, nhaP2; potassium/hydrogen antiporter 236.0 197.0 0.0 1.0 1.0 P 93.0 104.0 5.0 0.842639593908629 COG3263 NhaP-type_Na+/H+_and_K+/H+_antiporter_with_C-terminal_TrkAC_and_CorC_domains NhaP2 197.0 0.4720812182741117 0.5279187817258884 0.288953775988976 0.935606132608924 0.61227995429895 0.646652356619948 0 0 0 0 K11106 0.0314285714285714 0.0341880341880341 ttdT; L-tartrate/succinate antiporter 409.0 23.0 0.0 1.0 1.0 P 11.0 12.0 2.0 0.739130434782609 COG0471 Di-_and_tricarboxylate_antiporter CitT 23.0 0.4782608695652174 0.5217391304347826 0.521963836750102 0.595287408741734 0.5586256227459181 0.0733235719916319 0 1 0 1 K11107 0.0028571428571428 0.0455840455840455 yfaE; ferredoxin 48.0 15.0 11.0 2.0 0.789473684210526 C 1.0 18.0 3.0 0.473684210526316 COG0633 Ferredoxin Fdx 19.0 0.0526315789473684 0.9473684210526316 0.0525270473955826 0.0419796915982595 0.047253369496921 0.0105473557973231 0 0 0 0 K11127 0.0 0.0028490028490028 TEP1; telomerase protein component 1 139.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG2319 WD40_repeat WD40 1.0 0.0 1.0 0 0 0 0 K11130 0.4771428571428571 0.0113960113960113 NOP10, NOLA3; H/ACA ribonucleoprotein complex subunit 3 path:map03008 Ribosome biogenesis in eukaryotes 37.0 168.0 164.0 3.0 0.971098265895954 J 168.0 5.0 2.0 0.971098265895954 COG2260 rRNA_maturation_protein_Nop10,_contains_Zn-ribbon_domain Nop10 173.0 0.9710982658959536 0.0289017341040462 0.874211677047002 0.645731191507756 0.759971434277379 0.2284804855392459 1 1 1 1 K11131 0.7885714285714286 0.0 DKC1, NOLA4, CBF5; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] path:map03008 Ribosome biogenesis in eukaryotes 171.0 310.0 296.0 2.0 0.95679012345679 J 324.0 0.0 2.0 0.95679012345679 COG0130 tRNA_U55_pseudouridine_synthase_TruB,_may_also_work_on_U342_of_tmRNA TruB 324.0 1.0 0.0 0.955438654552948 0.965341065496127 0.9603898600245376 0.009902410943179 0 0 1 1 K11139 0.0 0.0028490028490028 hlyE, clyA, sheA; hemolysin E 303.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 28N3N 1.0 0.0 1.0 0 0 0 0 K11142 0.0057142857142857 0.0 LAP3; cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5] path:map00330,path:map00480,path:map01100 Arginine and proline metabolism,Glutathione metabolism,Metabolic pathways 475.0 2.0 0.0 1.0 1.0 E 2.0 0.0 1.0 1.0 COG0260 Leucyl_aminopeptidase PepB 2.0 1.0 0.0 0 0 0 0 K11144 0.0 0.0911680911680911 dnaI; primosomal protein DnaI 120.0 36.0 0.0 1.0 1.0 L 0.0 36.0 1.0 1.0 COG1484 DNA_replication_protein_DnaC DnaC 36.0 0.0 1.0 0.0186106958037304 0.0532474886909868 0.0359290922473586 0.0346367928872563 0 0 0 0 K11145 0.0 0.1823361823361823 mrnC; mini-ribonuclease III [EC:3.1.26.-] 100.0 64.0 0.0 1.0 1.0 J 0.0 64.0 1.0 1.0 COG1939 23S_rRNA_maturation_mini-RNase_III MrnC 64.0 0.0 1.0 0.0190660896184768 0.0301067853957938 0.0245864375071353 0.011040695777317 0 0 0 0 K11153 0.0 0.0028490028490028 RDH12; retinol dehydrogenase 12 [EC:1.1.1.300] path:map00830,path:map01100,path:map01240 Retinol metabolism,Metabolic pathways,Biosynthesis of cofactors 284.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K11159 0.0057142857142857 0.0626780626780626 K11159; carotenoid cleavage oxygenase [EC:1.13.11.-] 297.0 23.0 16.0 4.0 0.696969696969697 Q 2.0 31.0 3.0 0.878787878787879 COG3670 Carotenoid_cleavage_dioxygenase_or_a_related_enzyme 33.0 0.0606060606060606 0.9393939393939394 0.0019578420676633 0.0088214075679231 0.0053896248177932 0.0068635655002598 0 0 0 0 K11161 0.0 0.0056980056980056 RDH13; retinol dehydrogenase 13 [EC:1.1.1.300] path:map00830,path:map01100,path:map01240 Retinol metabolism,Metabolic pathways,Biosynthesis of cofactors 277.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K11163 0.0057142857142857 0.0 DHRS1; dehydrogenase/reductase SDR family member 1 [EC:1.1.-.-] 125.0 2.0 0.0 1.0 1.0 IQ 2.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 1.0 0.0 0 0 0 0 K11173 0.0 0.0142450142450142 ADHFE1; hydroxyacid-oxoacid transhydrogenase [EC:1.1.99.24] 423.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 5.0 0.0 1.0 0.104968351087425 0.738599400087522 0.4217838755874735 0.633631049000097 0 0 0 0 K11175 0.2914285714285714 0.8062678062678063 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] path:map00230,path:map00670,path:map01100,path:map01110 Purine metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites 87.0 400.0 391.0 4.0 0.968523002421308 F 109.0 304.0 5.0 0.956416464891041 COG0299 Folate-dependent_phosphoribosylglycinamide_formyltransferase_PurN PurN 413.0 0.2639225181598063 0.7360774818401937 0.0038378684181969 0.208372061026677 0.1061049647224369 0.2045341926084801 0 0 0 0 K11176 0.1714285714285714 0.0 purO; IMP cyclohydrolase [EC:3.5.4.10] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 180.0 60.0 0.0 1.0 1.0 F 60.0 0.0 1.0 1.0 COG3363 Archaeal_IMP_cyclohydrolase PurO 60.0 1.0 0.0 0.0059572981636118 0.0178861267022622 0.011921712432937 0.0119288285386503 0 0 0 0 K11177 0.0057142857142857 0.1196581196581196 yagR; xanthine dehydrogenase YagR molybdenum-binding subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 475.0 80.0 79.0 2.0 0.987654320987654 C 4.0 77.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 81.0 0.0493827160493827 0.9506172839506172 0.0193066625592177 0.0383814432640381 0.0288440529116279 0.0190747807048204 0 0 0 0 K11178 0.0085714285714285 0.1025641025641025 yagS; xanthine dehydrogenase YagS FAD-binding subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 279.0 56.0 55.0 2.0 0.982456140350877 C 3.0 54.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 57.0 0.0526315789473684 0.9473684210526316 0.0980118232853619 0.0593474573792488 0.0786796403323053 0.0386643659061131 0 0 0 0 K11179 0.0428571428571428 0.1339031339031339 tusE, dsrC; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-] path:map04122 Sulfur relay system 82.0 77.0 75.0 4.0 0.950617283950617 P 15.0 66.0 1.0 1.0 COG2920 Sulfur_transfer_complex_TusBCD_TusE_component,_DsrC_family_(tRNA_2-thiouridine_synthesizing_protein_C) TusE 81.0 0.1851851851851851 0.8148148148148148 0.0993085345782705 0.0261771818950233 0.0627428582366469 0.0731313526832472 0 0 0 0 K11180 0.0428571428571428 0.0797720797720797 dsrA; dissimilatory sulfite reductase alpha subunit [EC:1.8.99.5] path:map00633,path:map00920,path:map01100,path:map01120 Nitrotoluene degradation,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 335.0 51.0 0.0 1.0 1.0 C 20.0 31.0 1.0 1.0 COG2221 Dissimilatory_sulfite_reductase_(desulfoviridin),_alpha_and_beta_subunits DsrA 51.0 0.392156862745098 0.6078431372549019 0.213912064066275 0.0060359976413064 0.1099740308537907 0.2078760664249686 0 0 0 0 K11181 0.0457142857142857 0.0797720797720797 dsrB; dissimilatory sulfite reductase beta subunit [EC:1.8.99.5] path:map00633,path:map00920,path:map01100,path:map01120 Nitrotoluene degradation,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 310.0 56.0 0.0 1.0 1.0 C 24.0 32.0 1.0 1.0 COG2221 Dissimilatory_sulfite_reductase_(desulfoviridin),_alpha_and_beta_subunits DsrA 56.0 0.4285714285714285 0.5714285714285714 0.0694262744502954 0.0049184455891389 0.0371723600197171 0.0645078288611565 0 0 0 0 K11183 0.0 0.0 fruB, fpr; multiphosphoryl transfer protein [EC:2.7.1.202] path:map02060 Phosphotransferase system (PTS) 51.0 50.0 2.0 0.980769230769231 G 0.0 0.0 5.0 0.75 COG1080 Phosphoenolpyruvate-protein_kinase_(PTS_system_EI_component_in_bacteria) PtsA 0.0 0 0 0 0 K11184 0.0 0.0683760683760683 chr, crh; catabolite repression HPr-like protein 82.0 26.0 0.0 1.0 1.0 G 0.0 26.0 1.0 1.0 COG1925 HPr_or_related_phosphotransfer_protein PtsH 26.0 0.0 1.0 0.0068619865326635 0.0569122034350868 0.0318870949838751 0.0500502169024233 0 0 0 0 K11189 0.0628571428571428 0.5327635327635327 41.0 292.0 289.0 3.0 0.986486486486486 G 32.0 263.0 5.0 0.935810810810811 COG1925 HPr_or_related_phosphotransfer_protein PtsH 295.0 0.1084745762711864 0.8915254237288136 0.0197856110998882 0.391164878541342 0.2054752448206151 0.3713792674414538 0 0 0 0 K11191 0.0 0.0142450142450142 458.0 5.0 0.0 1.0 1.0 G 0.0 5.0 2.0 0.8 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 5.0 0.0 1.0 0.0545185338361527 0.195946057167028 0.1252322955015903 0.1414275233308753 0 0 0 0 K11192 0.0 0.0142450142450142 murP; N-acetylmuramic acid PTS system EIICB component [EC:2.7.1.192] path:map00520,path:map02060 Amino sugar and nucleotide sugar metabolism,Phosphotransferase system (PTS) 458.0 5.0 0.0 1.0 1.0 G 0.0 5.0 2.0 0.8 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 5.0 0.0 1.0 0.0558361110727686 0.195542454316296 0.1256892826945323 0.1397063432435274 0 0 0 0 K11194 0.0 0.0028490028490028 levD; fructose PTS system EIIA component [EC:2.7.1.202] path:map00051,path:map02060 Fructose and mannose metabolism,Phosphotransferase system (PTS) 141.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG2893 Phosphotransferase_system,_mannose/fructose-specific_component_IIA ManX 1.0 0.0 1.0 0 0 0 0 K11196 0.0 0.0028490028490028 levF; fructose PTS system EIIC component path:map00051,path:map02060 Fructose and mannose metabolism,Phosphotransferase system (PTS) 265.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 1.0 0.0 1.0 0 0 0 0 K11198 0.0 0.0028490028490028 638.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 1.0 0.0 1.0 0 0 0 0 K11199 0.0 0.0028490028490028 638.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 1.0 0.0 1.0 0 0 0 0 K11200 0.0 0.0028490028490028 mngA, hrsA; 2-O-A-mannosyl-D-glycerate PTS system EIIABC component [EC:2.7.1.195] path:map02060 Phosphotransferase system (PTS) 638.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 1.0 0.0 1.0 0 0 0 0 K11201 0.0 0.017094017094017 frvA; fructose-like PTS system EIIA component [EC:2.7.1.-] 29.0 10.0 0.0 1.0 1.0 G 0.0 10.0 4.0 0.4 COG1080 Phosphoenolpyruvate-protein_kinase_(PTS_system_EI_component_in_bacteria) PtsA 10.0 0.0 1.0 0.01913039157545 0.0433605103390301 0.03124545095724 0.0242301187635801 0 0 0 0 K11202 0.0 0.0256410256410256 fryB; fructose-like PTS system EIIB component [EC:2.7.1.-] 99.0 15.0 0.0 1.0 1.0 G 0.0 15.0 3.0 0.733333333333333 COG1445 Phosphotransferase_system_fructose-specific_component_IIB FrwB 15.0 0.0 1.0 0.0189119964386916 0.0364931126984611 0.0277025545685763 0.0175811162597695 0 0 0 0 K11203 0.0 0.0199430199430199 fryC, frvB; fructose-like PTS system EIIC or EIIBC or EIIABC component 329.0 10.0 9.0 2.0 0.909090909090909 G 0.0 11.0 2.0 0.909090909090909 COG1299 Phosphotransferase_system,_fructose-specific_IIC_component FrwC 11.0 0.0 1.0 0.02589074193131 0.057997995455254 0.041944368693282 0.032107253523944 0 0 0 0 K11206 0.1114285714285714 0.3504273504273504 NIT1, ybeM; deaminated glutathione amidase [EC:3.5.1.128] 143.0 173.0 165.0 5.0 0.93010752688172 S 41.0 145.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 186.0 0.2204301075268817 0.7795698924731183 0.0098184465406453 0.283687308697699 0.1467528776191721 0.2738688621570537 0 0 0 0 K11208 0.0 0.0113960113960113 yncG; GST-like protein 197.0 5.0 0.0 1.0 1.0 O 0.0 5.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 5.0 0.0 1.0 9.62021508311657e-12 0.120981925182442 0.0604909625960311 0.1209819251728217 0 0 0 0 K11209 0.0 0.1994301994301994 yghU, yfcG; GSH-dependent disulfide-bond oxidoreductase [EC:1.8.4.-] 163.0 129.0 123.0 2.0 0.955555555555556 O 0.0 135.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 135.0 0.0 1.0 0.0019448497216388 0.0285395904065512 0.015242220064095 0.0265947406849124 0 0 0 0 K11210 0.0 0.0455840455840455 fosB; metallothiol transferase [EC:2.5.1.-] 108.0 18.0 0.0 1.0 1.0 E 0.0 18.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 18.0 0.0 1.0 0.0113348321950735 0.0641623710668991 0.0377486016309863 0.0528275388718255 0 0 0 0 K11211 0.0 0.0455840455840455 kdkA; 3-deoxy-D-manno-octulosonic acid kinase [EC:2.7.1.166] path:map00540 Lipopolysaccharide biosynthesis 151.0 10.0 5.0 3.0 0.555555555555556 H 0.0 18.0 4.0 0.611111111111111 COG3642 tRNA_A-37_threonylcarbamoyl_transferase_component_Bud32 Bud32 18.0 0.0 1.0 0.0294368425792833 0.168025201296338 0.0987310219378106 0.1385883587170547 0 0 0 0 K11212 0.3857142857142857 0.0968660968660968 cofD; LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.28] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 237.0 116.0 60.0 2.0 0.674418604651163 H 138.0 34.0 1.0 1.0 COG0391 Archaeal_2-phospho-L-lactate_transferase/Bacterial_gluconeogenesis_factor,_CofD/UPF0052_family CofD 172.0 0.8023255813953488 0.1976744186046511 0.827099987897108 0.942655541060581 0.8848777644788446 0.1155555531634729 1 1 1 1 K11214 0.0 0.0142450142450142 SHPK; sedoheptulokinase [EC:2.7.1.14] path:map00710,path:map01100 Carbon fixation in photosynthetic organisms,Metabolic pathways 428.0 4.0 3.0 2.0 0.8 G 0.0 5.0 2.0 0.8 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 5.0 0.0 1.0 0.137893481781285 0.248301211873606 0.1930973468274455 0.110407730092321 0 0 0 0 K11216 0.02 0.0569800569800569 lsrK; autoinducer-2 kinase [EC:2.7.1.189] path:map02024 Quorum sensing 223.0 25.0 19.0 2.0 0.806451612903226 G 9.0 22.0 3.0 0.612903225806452 COG1070 Sugar_(pentulose_or_hexulose)_kinase XylB 31.0 0.2903225806451613 0.7096774193548387 0.878437436174721 0.911463644069436 0.8949505401220785 0.033026207894715 1 1 1 1 K11236 0.0028571428571428 0.0 CDC24; cell division control protein 24 path:map04011 MAPK signaling pathway - yeast 270.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG0170 Dolichol_kinase SEC59 1.0 1.0 0.0 0 0 0 0 K11249 0.0 0.0142450142450142 eamB; cysteine/O-acetylserine efflux protein 189.0 4.0 3.0 2.0 0.8 E 0.0 5.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 5.0 0.0 1.0 0.0884435575031833 0.237549475933151 0.1629965167181671 0.1491059184299677 0 0 0 0 K11250 0.0 0.0427350427350427 leuE; leucine efflux protein 196.0 19.0 0.0 1.0 1.0 E 0.0 19.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 19.0 0.0 1.0 0.0192671364062239 0.0516754740725738 0.0354713052393988 0.0324083376663499 0 0 0 0 K11258 0.0342857142857142 0.0256410256410256 ilvM; acetolactate synthase II small subunit [EC:2.2.1.6] path:map00290,path:map00650,path:map00660,path:map00770,path:map01100,path:map01110,path:map01210,path:map01230 Valine, leucine and isoleucine biosynthesis,Butanoate metabolism,C5-Branched dibasic acid metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 62.0 19.0 18.0 2.0 0.95 S 12.0 9.0 3.0 0.571428571428571 arCOG05680 21.0 0.5714285714285714 0.4285714285714285 0.0087695745193789 0.071592416881807 0.0401809957005929 0.062822842362428 0 0 0 0 K11260 0.1714285714285714 0.0 fwdG; 4Fe-4S ferredoxin path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 59.0 81.0 0.0 1.0 1.0 C 80.0 0.0 1.0 1.0 COG1145 Ferredoxin NapF 80.0 1.0 0.0 0.601313571887842 0.954879815363492 0.778096693625667 0.35356624347565 0 0 0 1 K11261 0.2171428571428571 0.1196581196581196 fwdE, fmdE; formylmethanofuran dehydrogenase subunit E [EC:1.2.7.12] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 69.0 171.0 159.0 4.0 0.914438502673797 C 110.0 69.0 4.0 0.812834224598931 COG2191 Formylmethanofuran_dehydrogenase_subunit_E FwdE 179.0 0.6145251396648045 0.3854748603351955 0.419928242304473 0.501117942896205 0.460523092600339 0.081189700591732 0 0 0 0 K11263 0.1228571428571428 0.1196581196581196 bccA, pccA; acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14] path:map00061,path:map00280,path:map00620,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Valine, leucine and isoleucine degradation,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 521.0 125.0 0.0 1.0 1.0 I 55.0 70.0 2.0 0.88 COG4770 Acetyl/propionyl-CoA_carboxylase,_alpha_subunit PccA 125.0 0.44 0.56 0.0003052836013114 0.0508149755992939 0.0255601296003026 0.0505096919979825 0 0 0 0 K11264 0.0028571428571428 0.037037037037037 scpB, mmcD; methylmalonyl-CoA decarboxylase [EC:4.1.1.-] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 249.0 16.0 0.0 1.0 1.0 I 1.0 15.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 16.0 0.0625 0.9375 0.0176369131582972 0.0132526683828551 0.0154447907705761 0.004384244775442 0 0 0 0 K11273 0.0 0.0 DDX11, CHL1, CTF1; chromosome transmission fidelity protein 1 [EC:3.6.4.13] 229.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG1199 Rad3-related_DNA_helicase_DinG DinG 1.0 1.0 0.0 0 0 0 0 K11275 0.0 0.0056980056980056 H1_5; histone H1/5 336.0 2.0 0.0 1.0 1.0 J 0.0 2.0 1.0 1.0 COG0532 Translation_initiation_factor_IF-2,_a_GTPase InfB 2.0 0.0 1.0 0 0 0 0 K11278 0.0171428571428571 0.0 NPM3; nucleophosmin 3 124.0 5.0 3.0 2.0 0.714285714285714 U 7.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 7.0 1.0 0.0 0.751724098734794 0.940587131427508 0.846155615081151 0.1888630326927141 0 0 1 1 K11294 0.0114285714285714 0.0 NCL, NSR1; nucleolin path:map05130 Pathogenic Escherichia coli infection 425.0 4.0 0.0 1.0 1.0 A 4.0 0.0 1.0 1.0 KOG0118 4.0 1.0 0.0 5.57065996842095e-21 1.94435957672721e-15 9.721825736935892e-16 1.944354006067242e-15 0 0 0 0 K11311 0.0 0.0056980056980056 antC; anthranilate 1,2-dioxygenase reductase component [EC:1.18.1.-] path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 187.0 2.0 0.0 1.0 1.0 C 0.0 2.0 2.0 0.5 COG0633 Ferredoxin Fdx 2.0 0.0 1.0 0 0 0 0 K11312 0.0542857142857142 0.1481481481481481 K11312; cupin 2 domain-containing protein 26.0 35.0 4.0 3.0 0.466666666666667 G 20.0 55.0 5.0 0.426666666666667 COG0662 Mannose-6-phosphate_isomerase,_cupin_superfamily ManC 75.0 0.2666666666666666 0.7333333333333333 0.0280626792189621 0.13572722691166 0.081894953065311 0.1076645476926979 0 0 0 0 K11313 0.0142857142857142 0.0 SUPT3H, SPT3; transcription initiation protein SPT3 path:map05202 Transcriptional misregulation in cancer 65.0 5.0 0.0 1.0 1.0 K 5.0 0.0 1.0 1.0 COG1644 DNA-directed_RNA_polymerase,_subunit_N_(RpoN/RPB10) RPB10 5.0 1.0 0.0 0.0451794773347385 0.135494246617643 0.0903368619761907 0.0903147692829045 0 0 0 0 K11325 0.0 0.0598290598290598 K11325; L-cysteine/cystine lyase 337.0 20.0 18.0 2.0 0.909090909090909 E 0.0 22.0 1.0 1.0 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 22.0 0.0 1.0 0.0132190525238398 0.797013053743282 0.4051160531335609 0.7837940012194422 0 0 0 0 K11326 0.0 0.0227920227920227 nrsA, czcA; cation efflux system protein involved in nickel and cobalt tolerance path:map02020 Two-component system 717.0 9.0 0.0 1.0 1.0 P 0.0 9.0 1.0 1.0 COG3696 Cu/Ag_efflux_pump_CusA CusA 9.0 0.0 1.0 0.010384498515847 0.0258014532373182 0.0180929758765826 0.0154169547214711 0 0 0 0 K11327 0.0 0.0028490028490028 nrsB; membrane fusion protein, cation efflux system path:map02020 Two-component system 136.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 2.0 0.0 1.0 0 0 0 0 K11328 0.0 0.0028490028490028 nrsS, rppB; two-component system, OmpR family, Ni(II)-sensor and/or redox sensor kinase NrsS [EC:2.7.13.3] path:map02020 Two-component system 454.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG5002 Sensor_histidine_kinase_WalK WalK 1.0 0.0 1.0 0 0 0 0 K11329 0.0 0.0683760683760683 rpaB; two-component system, OmpR family, response regulator RpaB path:map02020 Two-component system 221.0 17.0 9.0 3.0 0.607142857142857 K 0.0 28.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 28.0 0.0 1.0 0.00264538384188 0.0056749225517066 0.0041601531967933 0.0030295387098266 0 0 0 0 K11330 0.0 0.0056980056980056 nrsR, rppA; two-component system, OmpR family, Ni(II)-responsive and/or redox-responsive regulator NrsR path:map02020 Two-component system 75.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 3.0 0.0 1.0 0 0 0 0 K11332 0.0 0.0313390313390313 nblR; two-component system, OmpR family, response regulator NblR path:map02020 Two-component system 228.0 6.0 3.0 3.0 0.545454545454545 K 0.0 11.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 11.0 0.0 1.0 4.84231133481924e-13 6.54212243931053e-09 3.271303335222006e-09 6.541638208177048e-09 0 0 0 0 K11333 0.0028571428571428 0.0598290598290598 bchX; 3,8-divinyl chlorophyllide a/chlorophyllide a reductase subunit X [EC:1.3.7.14 1.3.7.15] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 119.0 11.0 1.0 5.0 0.423076923076923 K 1.0 25.0 2.0 0.576923076923077 COG1348 Nitrogenase_ATPase_subunit_NifH/coenzyme_F430_biosynthesis_subunit_CfbC NifH/CfbC 26.0 0.0384615384615384 0.9615384615384616 0.0130755548805998 0.018719758848372 0.0158976568644859 0.0056442039677722 0 0 0 0 K11334 0.0028571428571428 0.0398860398860398 bchY; 3,8-divinyl chlorophyllide a/chlorophyllide a reductase subunit Y [EC:1.3.7.14 1.3.7.15] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 390.0 17.0 16.0 2.0 0.944444444444444 C 1.0 17.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 18.0 0.0555555555555555 0.9444444444444444 0.0241259169580712 0.0261544421797359 0.0251401795689035 0.0020285252216647 0 0 0 0 K11335 0.0028571428571428 0.0398860398860398 bchZ; 3,8-divinyl chlorophyllide a/chlorophyllide a reductase subunit Z [EC:1.3.7.14 1.3.7.15] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 446.0 18.0 0.0 1.0 1.0 C 1.0 17.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 18.0 0.0555555555555555 0.9444444444444444 0.0183929102337901 0.020145135147789 0.0192690226907895 0.0017522249139989 0 0 0 0 K11336 0.0 0.0398860398860398 bchF; 3-vinyl bacteriochlorophyllide hydratase [EC:4.2.1.165] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 148.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 294R4 14.0 0.0 1.0 0.0260360014537572 0.0428506172997789 0.034443309376768 0.0168146158460216 0 0 0 0 K11337 0.0 0.0484330484330484 bchC; bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 303.0 14.0 12.0 3.0 0.823529411764706 E 0.0 17.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 17.0 0.0 1.0 0.0389159802057045 0.0933786135111272 0.0661472968584158 0.0544626333054227 0 0 0 0 K11354 0.0 0.0142450142450142 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] path:map02020 Two-component system 729.0 6.0 0.0 1.0 1.0 T 0.0 6.0 1.0 1.0 COG4251 Bacteriophytochrome_(light-regulated_signal_transduction_histidine_kinase) 6.0 0.0 1.0 1.41115772975394e-06 1.80860833321479e-06 1.609883031484365e-06 3.9745060346085005e-07 0 0 0 0 K11355 0.0 0.0227920227920227 rcp1; two-component system, chemotaxis family, response regulator Rcp1 path:map02020 Two-component system 143.0 8.0 0.0 1.0 1.0 T 0.0 8.0 1.0 1.0 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 8.0 0.0 1.0 0.0032109689564726 0.005407112361059 0.0043090406587658 0.0021961434045863 0 0 0 0 K11356 0.0 0.0284900284900284 cikA; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] path:map02020 Two-component system 274.0 12.0 0.0 1.0 1.0 T 0.0 12.0 2.0 0.833333333333333 COG0642 Signal_transduction_histidine_kinase BaeS 12.0 0.0 1.0 0.0014717558338702 0.0035198906496666 0.0024958232417684 0.0020481348157964 0 0 0 0 K11357 0.0 0.0199430199430199 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3] path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 377.0 11.0 0.0 1.0 1.0 T 0.0 11.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 11.0 0.0 1.0 7.39588149007077e-08 1.57839305135176e-12 3.6980196646879526e-08 7.395723650765636e-08 0 0 0 0 K11358 0.0028571428571428 0.1367521367521367 yhdR; aspartate aminotransferase [EC:2.6.1.1] path:map00220,path:map00250,path:map00270,path:map00330,path:map00350,path:map00360,path:map00400,path:map00401,path:map00950,path:map00960,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Cysteine and methionine metabolism,Arginine and proline metabolism,Tyrosine metabolism,Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Isoquinoline alkaloid biosynthesis,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 333.0 54.0 51.0 2.0 0.947368421052632 E 1.0 56.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 57.0 0.0175438596491228 0.9824561403508772 0.0081837288768576 0.475552428032367 0.2418680784546123 0.4673686991555094 0 0 0 0 K11381 0.04 0.2592592592592592 bkdA; 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] path:map00280,path:map00640,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 233.0 169.0 167.0 2.0 0.988304093567252 C 14.0 140.0 3.0 0.842105263157895 COG0022 Pyruvate/2-oxoglutarate/acetoin_dehydrogenase_complex,_dehydrogenase_(E1)_component,_beta_subunit AcoB 154.0 0.0909090909090909 0.9090909090909092 0.750258608640903 0.8228601867983 0.7865593977196015 0.0726015781573969 1 1 1 1 K11382 0.0 0.0056980056980056 pgtP; MFS transporter, OPA family, phosphoglycerate transporter protein path:map02020 Two-component system 450.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG2271 Sugar_phosphate_permease UhpC 2.0 0.0 1.0 0 0 0 0 K11383 0.0 0.0398860398860398 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] path:map02020 Two-component system 464.0 18.0 0.0 1.0 1.0 T 0.0 18.0 1.0 1.0 COG5002 Sensor_histidine_kinase_WalK WalK 18.0 0.0 1.0 0.007151948171897 0.0277843162162495 0.0174681321940732 0.0206323680443525 0 0 0 0 K11384 0.0 0.0341880341880341 algB; two-component system, NtrC family, response regulator AlgB path:map02020 Two-component system 429.0 18.0 0.0 1.0 1.0 T 0.0 18.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 18.0 0.0 1.0 0.0042235710813808 0.0091071052109626 0.0066653381461717 0.0048835341295818 0 0 0 0 K11385 0.0 0.0028490028490028 embA; arabinosyltransferase A [EC:2.4.2.-] path:map00572 Arabinogalactan biosynthesis - Mycobacterium 1104.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 1.0 0.0 1.0 0 0 0 0 K11386 0.0 0.0142450142450142 embB; arabinosyltransferase B [EC:2.4.2.-] path:map00572 Arabinogalactan biosynthesis - Mycobacterium 920.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 8.0 0.0 1.0 0.0042550050478148 0.0075035235528634 0.005879264300339 0.0032485185050486 0 0 0 0 K11387 0.0 0.0142450142450142 embC; arabinosyltransferase C [EC:2.4.2.-] path:map00571 Lipoarabinomannan (LAM) biosynthesis 953.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 8.0 0.0 1.0 7.69664099734094e-10 7.54832028661585e-08 3.812643348294629e-08 7.47135387664244e-08 0 0 0 0 K11389 0.0971428571428571 0.0199430199430199 gapor; glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) [EC:1.2.7.6] path:map00010,path:map01100,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 520.0 47.0 0.0 1.0 1.0 C 40.0 7.0 1.0 1.0 COG2414 Aldehyde:ferredoxin_oxidoreductase YdhV 47.0 0.851063829787234 0.1489361702127659 0.0130209718086995 0.0226735686120547 0.0178472702103771 0.0096525968033552 0 0 0 0 K11391 0.0 0.0598290598290598 rlmG; 23S rRNA (guanine1835-N2)-methyltransferase [EC:2.1.1.174] 299.0 21.0 0.0 1.0 1.0 J 0.0 21.0 1.0 1.0 COG2813 16S_rRNA_G1207_methylase_RsmC RsmC 21.0 0.0 1.0 0.0745658705293595 0.0879677684112569 0.0812668194703082 0.0134018978818974 0 0 0 0 K11392 0.0085714285714285 0.0683760683760683 rsmF; 16S rRNA (cytosine1407-C5)-methyltransferase [EC:2.1.1.178] 194.0 27.0 0.0 1.0 1.0 J 3.0 24.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 27.0 0.1111111111111111 0.8888888888888888 0.224429093092127 0.709201613871118 0.4668153534816225 0.484772520778991 0 0 0 0 K11395 0.0371428571428571 0.0 kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [EC:4.1.2.55] path:map00030,path:map00052,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 276.0 12.0 11.0 2.0 0.923076923076923 E 13.0 0.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 13.0 1.0 0.0 0.006504405098942 0.011576713149499 0.0090405591242205 0.005072308050557 0 0 0 0 K11410 0.0 0.0769230769230769 acdH; short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] path:map00280,path:map01100,path:map01110 Valine, leucine and isoleucine degradation,Metabolic pathways,Biosynthesis of secondary metabolites 370.0 28.0 27.0 2.0 0.96551724137931 I 0.0 29.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 29.0 0.0 1.0 0.0012781906667975 0.0241859407633484 0.0127320657150729 0.0229077500965509 0 0 0 0 K11416 0.0114285714285714 0.0 SIRT6, SIR2L6; NAD+-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286] path:map00760,path:map01100,path:map04714,path:map05230 Nicotinate and nicotinamide metabolism,Metabolic pathways,Thermogenesis,Central carbon metabolism in cancer 131.0 5.0 0.0 1.0 1.0 BK 5.0 0.0 1.0 1.0 COG0846 NAD-dependent_protein_deacetylase,_SIR2_family SIR2 5.0 1.0 0.0 0.723379816736646 0.918317402984341 0.8208486098604935 0.1949375862476949 0 0 0 1 K11418 0.0 0.0142450142450142 HDAC11; histone deacetylase 11 [EC:3.5.1.98] path:map04613,path:map05034,path:map05203 Neutrophil extracellular trap formation,Alcoholism,Viral carcinogenesis 283.0 5.0 0.0 1.0 1.0 BQ 0.0 5.0 1.0 1.0 COG0123 Acetoin_utilization_deacetylase_AcuC_or_a_related_deacetylase AcuC 5.0 0.0 1.0 0.50733542737584 0.523038913028037 0.5151871702019385 0.0157034856521969 0 0 0 1 K11422 0.0028571428571428 0.0 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 159.0 1.0 0.0 1.0 1.0 OU 1.0 0.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 1.0 1.0 0.0 0 0 0 0 K11423 0.0 0.0028490028490028 SETD2; [histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 194.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 1.0 0.0 1.0 0 0 0 0 K11424 0.0028571428571428 0.0028490028490028 WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357] path:map00310,path:map01100,path:map05202 Lysine degradation,Metabolic pathways,Transcriptional misregulation in cancer 131.0 1.0 0.0 2.0 0.5 O 1.0 1.0 2.0 0.5 COG2940 SET_domain-containing_protein_(function_unknown) SET 2.0 0.5 0.5 0 0 0 0 K11434 0.0142857142857142 0.0256410256410256 PRMT1; type I protein arginine methyltransferase [EC:2.1.1.319] path:map04068,path:map04922 FoxO signaling pathway,Glucagon signaling pathway 190.0 8.0 5.0 5.0 0.5 J 5.0 11.0 3.0 0.75 COG4076 Predicted_RNA_methylase 16.0 0.3125 0.6875 0.675710249157983 0.345331830615756 0.5105210398868695 0.3303784185422269 0 1 0 1 K11440 0.0114285714285714 0.0085470085470085 gbsB; choline dehydrogenase [EC:1.1.1.1] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 373.0 7.0 0.0 1.0 1.0 C 4.0 3.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 7.0 0.5714285714285714 0.4285714285714285 0.18223612287016 0.248529707931853 0.2153829154010065 0.066293585061693 0 0 0 0 K11441 0.0 0.0056980056980056 kguK; dehydrogluconokinase [EC:2.7.1.13] path:map00030,path:map01100,path:map01120 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments 285.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 2.0 0.0 1.0 0 0 0 0 K11442 0.0 0.017094017094017 K11442; putative uridylyltransferase [EC:2.7.7.-] 442.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG4284 UDP-N-acetylglucosamine_pyrophosphorylase QRI1 6.0 0.0 1.0 0.0654315115029027 0.309721930344272 0.1875767209235873 0.2442904188413692 0 0 0 0 K11443 0.0342857142857142 0.1396011396011396 divK; two-component system, cell cycle response regulator DivK path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 55.0 84.0 76.0 2.0 0.91304347826087 T 25.0 66.0 4.0 0.5 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 91.0 0.2747252747252747 0.7252747252747253 0.0025031514155344 0.0298956731749365 0.0161994122952354 0.0273925217594021 0 0 0 0 K11444 0.0 0.0056980056980056 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 322.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 2.0 0.0 1.0 0 0 0 0 K11446 0.0028571428571428 0.0 KDM5, JARID1; [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67] 159.0 1.0 0.0 1.0 1.0 OU 1.0 0.0 1.0 1.0 COG2940 SET_domain-containing_protein_(function_unknown) SET 1.0 1.0 0.0 0 0 0 0 K11447 0.0 0.0028490028490028 UTX, KDM6A; lysine-specific demethylase 6A [EC:1.14.11.68] path:map05202 Transcriptional misregulation in cancer 424.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K11472 0.0514285714285714 0.2108262108262108 glcE; glycolate oxidase FAD binding subunit path:map00630,path:map01100,path:map01110,path:map01120 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 179.0 98.0 0.0 1.0 1.0 C 20.0 78.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 98.0 0.2040816326530612 0.7959183673469388 0.439514709313234 0.970136927443849 0.7048258183785415 0.530622218130615 0 0 0 0 K11473 0.1171428571428571 0.3675213675213675 glcF; glycolate oxidase iron-sulfur subunit path:map00630,path:map01100,path:map01110,path:map01120 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 130.0 216.0 0.0 1.0 1.0 C 57.0 159.0 2.0 0.99537037037037 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 216.0 0.2638888888888889 0.7361111111111112 0.0018133303237243 0.446627843834692 0.2242205870792081 0.4448145135109677 0 0 0 0 K11474 0.0 0.0227920227920227 glcC; GntR family transcriptional regulator, glc operon transcriptional activator 239.0 9.0 0.0 1.0 1.0 K 0.0 9.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 9.0 0.0 1.0 0.0105723522523089 0.0228168040982847 0.0166945781752968 0.0122444518459758 0 0 0 0 K11475 0.0 0.037037037037037 vanR; GntR family transcriptional regulator, vanillate catabolism transcriptional regulator 189.0 17.0 0.0 1.0 1.0 K 0.0 17.0 1.0 1.0 COG1802 DNA-binding_transcriptional_regulator,_GntR_family GntR 17.0 0.0 1.0 0.0092037524717312 0.0275177920004562 0.0183607722360937 0.018314039528725 0 0 0 0 K11476 0.0 0.0142450142450142 gntR; GntR family transcriptional regulator, gluconate operon transcriptional repressor 210.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1802 DNA-binding_transcriptional_regulator,_GntR_family GntR 6.0 0.0 1.0 0.0098849770082643 0.0229153112271589 0.0164001441177116 0.0130303342188946 0 0 0 0 K11477 0.0028571428571428 0.0541310541310541 glcG; glc operon protein GlcG 104.0 6.0 1.0 3.0 0.461538461538462 S 1.0 22.0 3.0 0.739130434782609 COG3193 Heme-binding_protein_HbpS,_GlcG/HbpS_family GlcG 23.0 0.0434782608695652 0.9565217391304348 0.0141826177749819 0.0849137418450085 0.0495481798099951 0.0707311240700266 0 0 0 0 K11517 0.0085714285714285 0.0 HAO; (S)-2-hydroxy-acid oxidase [EC:1.1.3.15] path:map00630,path:map01100,path:map01110,path:map01120,path:map01200,path:map04146 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Peroxisome 349.0 3.0 0.0 1.0 1.0 C 3.0 0.0 1.0 1.0 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 3.0 1.0 0.0 0 0 0 0 K11520 0.0 0.037037037037037 manS; two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3] path:map02020 Two-component system 408.0 14.0 0.0 1.0 1.0 T 0.0 14.0 2.0 0.857142857142857 COG5002 Sensor_histidine_kinase_WalK WalK 14.0 0.0 1.0 6.78103646541582e-05 0.0001870959092445 0.0001274531369493 0.0001192855445903 0 0 0 0 K11521 0.0 0.0341880341880341 manR; two-component system, OmpR family, manganese sensing response regulator path:map02020 Two-component system 220.0 19.0 18.0 3.0 0.904761904761905 T 0.0 21.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 21.0 0.0 1.0 4.58417906705405e-06 5.54382716239777e-05 3.0011225345515876e-05 5.085409255692365e-05 0 0 0 0 K11522 0.0 0.0341880341880341 pixG; two-component system, chemotaxis family, response regulator PixG path:map02020 Two-component system 289.0 18.0 13.0 2.0 0.782608695652174 T 0.0 23.0 3.0 0.739130434782609 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 23.0 0.0 1.0 0.0026918800000293 0.0255226912153611 0.0141072856076952 0.0228308112153318 0 0 0 0 K11523 0.0 0.0227920227920227 pixH; two-component system, chemotaxis family, response regulator PixH path:map02020 Two-component system 119.0 5.0 2.0 2.0 0.625 KT 0.0 8.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 8.0 0.0 1.0 0.0024901489559188 0.0042873333159058 0.0033887411359123 0.0017971843599869 0 0 0 0 K11524 0.0 0.0341880341880341 pixI; positive phototaxis protein PixI path:map02020 Two-component system 121.0 14.0 0.0 1.0 1.0 NT 0.0 14.0 1.0 1.0 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 14.0 0.0 1.0 0.0420490410869955 0.0825092174289191 0.0622791292579573 0.0404601763419236 0 0 0 0 K11525 0.0028571428571428 0.0683760683760683 pixJ; methyl-accepting chemotaxis protein PixJ path:map02020 Two-component system 100.0 36.0 21.0 2.0 0.705882352941176 T 1.0 49.0 9.0 0.725490196078431 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 50.0 0.02 0.98 0.0023212512088019 0.0088209603639557 0.0055711057863788 0.0064997091551538 0 0 0 0 K11526 0.0 0.0256410256410256 pixL; two-component system, chemotaxis family, sensor histidine kinase and response regulator PixL path:map02020 Two-component system 881.0 10.0 0.0 1.0 1.0 T 0.0 10.0 2.0 0.9 COG0643 Chemotaxis_protein_histidine_kinase_CheA CheA 10.0 0.0 1.0 0.0041818401508894 0.0121310276249679 0.0081564338879286 0.0079491874740784 0 0 0 0 K11527 0.0 0.0 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 88.0 84.0 3.0 0.946236559139785 T 0.0 0.0 12.0 0.43010752688172 COG0642 Signal_transduction_histidine_kinase BaeS 0.0 0 0 0 0 K11528 0.0 0.1737891737891738 glmU; UDP-N-acetylglucosamine pyrophosphorylase [EC:2.7.7.23] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 198.0 62.0 0.0 1.0 1.0 M 0.0 62.0 1.0 1.0 COG1207 Bifunctional_protein_GlmU,_N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase GlmU 62.0 0.0 1.0 0.606755560914964 0.298888368520902 0.452821964717933 0.3078671923940619 0 0 0 1 K11529 0.3885714285714285 0.3048433048433048 gck, gckA, GLYCTK; glycerate 2-kinase [EC:2.7.1.165] path:map00030,path:map00260,path:map00561,path:map00630,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Glycine, serine and threonine metabolism,Glycerolipid metabolism,Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 200.0 235.0 219.0 5.0 0.903846153846154 G 142.0 118.0 3.0 0.965384615384615 COG2379 Glycerate-2-kinase GckA 260.0 0.5461538461538461 0.4538461538461538 0.474862077435764 0.774183299813939 0.6245226886248515 0.299321222378175 0 0 0 0 K11530 0.0 0.0484330484330484 lsrG; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [EC:5.3.1.32] path:map02024 Quorum sensing 97.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG1359 Quinol_monooxygenase_YgiN YgiN 17.0 0.0 1.0 0.0444225043259301 0.15127635261172 0.097849428468825 0.1068538482857899 0 0 0 0 K11531 0.0 0.0284900284900284 lsrR; lsr operon transcriptional repressor path:map02024,path:map02026 Quorum sensing,Biofilm formation - Escherichia coli 300.0 11.0 0.0 1.0 1.0 K 0.0 11.0 1.0 1.0 COG2390 DNA-binding_transcriptional_regulator_LsrR,_DeoR_family DeoR 11.0 0.0 1.0 0.015260216927926 0.0304178709929662 0.0228390439604461 0.0151576540650401 0 0 0 0 K11532 0.0 0.1339031339031339 glpX-SEBP; fructose-1,6-bisphosphatase II / sedoheptulose-1,7-bisphosphatase [EC:3.1.3.11 3.1.3.37] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 306.0 49.0 0.0 1.0 1.0 G 0.0 49.0 1.0 1.0 COG1494 Fructose-1,6-bisphosphatase/sedoheptulose_1,7-bisphosphatase_or_related_protein GlpX 49.0 0.0 1.0 0.0072264997586429 0.023038815510466 0.0151326576345544 0.0158123157518231 0 0 0 0 K11533 0.0 0.017094017094017 fas; fatty acid synthase, bacteria type [EC:2.3.1.-] path:map00061,path:map01100,path:map01212,path:map04931 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism,Insulin resistance 2912.0 4.0 2.0 2.0 0.666666666666667 IQ 0.0 6.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 6.0 0.0 1.0 9.98464710509962e-13 3.44449692838e-12 2.221480819444981e-12 2.4460322178700387e-12 0 0 0 0 K11534 0.0 0.0227920227920227 deoR; DeoR family transcriptional regulator, deoxyribose operon repressor 233.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 8.0 0.0 1.0 0.0139049125971989 0.0316881305253809 0.0227965215612899 0.017783217928182 0 0 0 0 K11535 0.0 0.0313390313390313 nupC; nucleoside transport protein 382.0 12.0 11.0 3.0 0.857142857142857 F 0.0 14.0 1.0 1.0 COG1972 Nucleoside_permease_NupC NupC 14.0 0.0 1.0 0.0331345349617182 0.0494895378126747 0.0413120363871964 0.0163550028509565 0 0 0 0 K11537 0.0 0.0398860398860398 xapB; MFS transporter, NHS family, xanthosine permease 390.0 15.0 14.0 2.0 0.9375 G 0.0 16.0 2.0 0.9375 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 16.0 0.0 1.0 0.0199974286536187 0.0265077324249838 0.0232525805393012 0.0065103037713651 0 0 0 0 K11540 0.0028571428571428 0.017094017094017 CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 215.0 6.0 5.0 2.0 0.857142857142857 F 1.0 6.0 1.0 1.0 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 7.0 0.1428571428571428 0.8571428571428571 0.0545138650974701 0.165222170902914 0.109868018000192 0.1107083058054438 0 0 0 0 K11541 0.0028571428571428 0.0028490028490028 URA2; carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2] path:map00240,path:map00250,path:map01100,path:map01240 Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of cofactors 368.0 1.0 0.0 2.0 0.5 F 1.0 1.0 1.0 1.0 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 2.0 0.5 0.5 0 0 0 0 K11600 0.8 0.0 RRP41, EXOSC4, SKI6; exosome complex component RRP41 path:map03018 RNA degradation 203.0 281.0 279.0 2.0 0.992932862190813 J 283.0 0.0 2.0 0.992932862190813 COG0689 Ribonuclease_PH Rph 283.0 1.0 0.0 0.125990242737997 0.691292568029703 0.4086414053838499 0.565302325291706 0 0 0 0 K11601 0.0028571428571428 0.0398860398860398 mntC; manganese transport system substrate-binding protein path:map02010,path:map02020 ABC transporters,Two-component system 288.0 17.0 0.0 1.0 1.0 P 1.0 16.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 17.0 0.0588235294117647 0.9411764705882352 0.0232991671334888 0.0491121143538785 0.0362056407436836 0.0258129472203897 0 0 0 0 K11602 0.0 0.0341880341880341 mntB; manganese transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 272.0 17.0 0.0 1.0 1.0 P 0.0 17.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 17.0 0.0 1.0 0.0075108801934037 0.0222499827061142 0.0148804314497589 0.0147391025127105 0 0 0 0 K11603 0.0 0.037037037037037 mntA; manganese transport system ATP-binding protein [EC:7.2.2.5] path:map02010,path:map02020 ABC transporters,Two-component system 234.0 15.0 0.0 1.0 1.0 P 0.0 15.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 15.0 0.0 1.0 0.010878498230766 0.0303206682832077 0.0205995832569868 0.0194421700524417 0 0 0 0 K11604 0.0057142857142857 0.0398860398860398 sitA; manganese/iron transport system substrate-binding protein path:map02010 ABC transporters 284.0 17.0 0.0 1.0 1.0 P 2.0 15.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 17.0 0.1176470588235294 0.8823529411764706 0.0108251648388451 0.0229723568726435 0.0168987608557443 0.0121471920337984 0 0 0 0 K11605 0.0 0.0398860398860398 sitC; manganese/iron transport system permease protein path:map02010 ABC transporters 275.0 15.0 0.0 1.0 1.0 P 0.0 15.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 15.0 0.0 1.0 0.0086921112528326 0.0176830131119255 0.013187562182379 0.0089909018590929 0 0 0 0 K11606 0.0 0.0398860398860398 sitD; manganese/iron transport system permease protein path:map02010 ABC transporters 264.0 15.0 0.0 1.0 1.0 P 0.0 15.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 15.0 0.0 1.0 0.018670880838347 0.0608928588790158 0.0397818698586814 0.0422219780406687 0 0 0 0 K11607 0.0057142857142857 0.0769230769230769 sitB; manganese/iron transport system ATP-binding protein path:map02010 ABC transporters 232.0 29.0 0.0 1.0 1.0 P 2.0 27.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 29.0 0.0689655172413793 0.9310344827586208 0.007300721057911 0.0161382831499617 0.0117195021039363 0.0088375620920506 0 0 0 0 K11608 0.0 0.0199430199430199 mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.301] 333.0 8.0 0.0 1.0 1.0 I 0.0 8.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 8.0 0.0 1.0 0.0004106558504391 0.0017445657152717 0.0010776107828554 0.0013339098648326 0 0 0 0 K11609 0.0 0.0142450142450142 kasAB; beta-ketoacyl ACP synthase [EC:2.3.1.293 2.3.1.294] 407.0 5.0 3.0 2.0 0.714285714285714 IQ 0.0 7.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 7.0 0.0 1.0 2.5872209165606e-22 5.0643182689961604e-14 2.5321591474341845e-14 5.064318243123951e-14 0 0 0 0 K11610 0.0 0.0256410256410256 mabA; beta-ketoacyl ACP reductase [EC:1.1.1.100] 234.0 9.0 0.0 1.0 1.0 IQ 0.0 9.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 9.0 0.0 1.0 0.0001959028877157 0.0031223860842746 0.0016591444859951 0.0029264831965589 0 0 0 0 K11611 0.0 0.0284900284900284 inhA; meromycolic acid enoyl-[acyl-carrier-protein] reductase [EC:1.3.1.118] 253.0 10.0 0.0 1.0 1.0 I 0.0 10.0 1.0 1.0 COG0623 Enoyl-[acyl-carrier-protein]_reductase_FabI FabI 10.0 0.0 1.0 9.25829993330074e-07 4.29201052513567e-06 2.608920259232872e-06 3.366180531805596e-06 0 0 0 0 K11614 0.0 0.0427350427350427 yufL, malK; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3] path:map02020 Two-component system 450.0 23.0 0.0 1.0 1.0 T 0.0 23.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 23.0 0.0 1.0 0.0023394461799722 0.0196969895712487 0.0110182178756104 0.0173575433912765 0 0 0 0 K11615 0.0 0.0512820512820512 malR; two-component system, CitB family, response regulator MalR path:map02020 Two-component system 180.0 14.0 8.0 3.0 0.583333333333333 KT 0.0 24.0 1.0 1.0 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 24.0 0.0 1.0 0.006632212572779 0.210899299880093 0.108765756226436 0.204267087307314 0 0 0 0 K11616 0.0 0.0113960113960113 maeN; malate:Na+ symporter path:map02020 Two-component system 423.0 5.0 4.0 2.0 0.833333333333333 C 0.0 6.0 1.0 1.0 COG3493 Na+/citrate_or_Na+/malate_symporter CitS 6.0 0.0 1.0 0.0161635509863845 0.0262055827589535 0.021184566872669 0.0100420317725689 0 0 0 0 K11617 0.0028571428571428 0.0655270655270655 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] path:map02020 Two-component system 190.0 30.0 29.0 2.0 0.967741935483871 T 1.0 30.0 3.0 0.806451612903226 COG4585 Signal_transduction_histidine_kinase_ComP ComP 31.0 0.032258064516129 0.967741935483871 0.009991341469513 0.876933149366536 0.4434622454180245 0.866941807897023 0 0 0 0 K11618 0.0 0.0569800569800569 liaR; two-component system, NarL family, response regulator LiaR path:map02020 Two-component system 201.0 15.0 8.0 3.0 0.6 K 0.0 25.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 25.0 0.0 1.0 0.0041989240400482 0.20350691580408 0.1038529199220641 0.1993079917640318 0 0 0 0 K11619 0.0 0.0227920227920227 liaI; lia operon protein LiaI path:map02020 Two-component system 101.0 4.0 0.0 1.0 1.0 KT 0.0 9.0 2.0 0.555555555555556 2B02J 9.0 0.0 1.0 0.0026434220751197 0.011221083179215 0.0069322526271673 0.0085776611040953 0 0 0 0 K11620 0.0 0.0028490028490028 liaH; lia operon protein LiaH path:map02020 Two-component system 66.0 2.0 0.0 1.0 1.0 KT 0.0 2.0 1.0 1.0 COG1842 Phage_shock_protein_A PspA 2.0 0.0 1.0 0 0 0 0 K11621 0.0028571428571428 0.0256410256410256 liaG; lia operon protein LiaG path:map02020 Two-component system 217.0 10.0 0.0 1.0 1.0 S 1.0 11.0 1.0 1.0 COG3595 Uncharacterized_conserved_protein_YvlB,_contains__DUF4097_and_DUF4098_domains YvlB 12.0 0.0833333333333333 0.9166666666666666 0.0260080438363029 0.0230792882161553 0.0245436660262291 0.0029287556201476 0 0 0 0 K11622 0.0 0.0455840455840455 liaF; lia operon protein LiaF path:map02020 Two-component system 142.0 17.0 15.0 2.0 0.894736842105263 S 0.0 19.0 1.0 1.0 COG4758 Membrane_protein_LiaF,_inhibitor_of_the_LiaRS_two-component_envelope_stress_sensory_system LiaF 19.0 0.0 1.0 0.0027584601216397 0.0058000210798174 0.0042792406007285 0.0030415609581777 0 0 0 0 K11623 0.0 0.0199430199430199 ydfH; two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3] path:map02020 Two-component system 328.0 7.0 0.0 1.0 1.0 T 0.0 7.0 2.0 0.857142857142857 COG4585 Signal_transduction_histidine_kinase_ComP ComP 7.0 0.0 1.0 0.0067237979723467 0.166297504644969 0.0865106513086578 0.1595737066726223 0 0 0 0 K11624 0.0 0.0113960113960113 ydfI; two-component system, NarL family, response regulator YdfI path:map02020 Two-component system 201.0 3.0 2.0 2.0 0.75 K 0.0 4.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 4.0 0.0 1.0 0.0650299658246601 0.13712335826383 0.101076662044245 0.0720933924391698 0 0 0 0 K11625 0.0 0.0028490028490028 ydfJ; membrane protein YdfJ path:map02020 Two-component system 1072.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1511 Uncharacterized_membrane_protein_YhgE,_phage_infection_protein_(PIP)_family YhgE 1.0 0.0 1.0 0 0 0 0 K11626 0.0114285714285714 0.0085470085470085 glnT; putative sodium/glutamine symporter path:map02020 Two-component system 435.0 8.0 0.0 1.0 1.0 E 5.0 3.0 1.0 1.0 COG1115 Na+/alanine_symporter AlsT 8.0 0.625 0.375 0.0187158147970576 0.0556314942649269 0.0371736545309922 0.0369156794678693 0 0 0 0 K11627 0.0457142857142857 0.0 pylS; pyrrolysyl-tRNA synthetase [EC:6.1.1.26] path:map00970 Aminoacyl-tRNA biosynthesis 267.0 17.0 0.0 1.0 1.0 J 17.0 0.0 1.0 1.0 arCOG00413 17.0 1.0 0.0 0.0034642867640554 0.0054381133582879 0.0044512000611716 0.0019738265942324 0 0 0 0 K11628 0.0 0.0028490028490028 mas; mycocerosic acid synthase [EC:2.3.1.111] 2105.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 1.0 0.0 1.0 0 0 0 0 K11629 0.0 0.0227920227920227 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3] path:map02020 Two-component system 322.0 10.0 0.0 1.0 1.0 T 0.0 10.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 10.0 0.0 1.0 0.0009445393528014 0.002686569323689 0.0018155543382452 0.0017420299708875 0 0 0 0 K11630 0.0 0.0199430199430199 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR path:map02020 Two-component system 224.0 3.0 1.0 3.0 0.428571428571429 T 0.0 7.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 7.0 0.0 1.0 0.0013367688241773 0.0021472325782526 0.0017420007012149 0.0008104637540753 0 0 0 0 K11631 0.0 0.017094017094017 bceA, vraD; bacitracin transport system ATP-binding protein path:map02010,path:map02020 ABC transporters,Two-component system 253.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 6.0 0.0 1.0 7.75617939011966e-12 1.64164024978206e-07 8.208589057879807e-08 1.6415626879881588e-07 0 0 0 0 K11632 0.0 0.0256410256410256 bceB, vraE; bacitracin transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 614.0 9.0 0.0 1.0 1.0 V 0.0 9.0 1.0 1.0 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 9.0 0.0 1.0 0.0039680897389504 0.0086033493864913 0.0062857195627208 0.0046352596475409 0 0 0 0 K11633 0.0 0.0056980056980056 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3] path:map02020 Two-component system 324.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 2.0 0.0 1.0 0 0 0 0 K11634 0.0 0.0028490028490028 yxdJ; two-component system, OmpR family, response regulator YxdJ path:map02020 Two-component system 232.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 1.0 0.0 1.0 0 0 0 0 K11635 0.0 0.0256410256410256 yxdL; putative ABC transport system ATP-binding protein path:map02020 Two-component system 248.0 12.0 0.0 1.0 1.0 V 0.0 12.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 12.0 0.0 1.0 0.0058088009941584 0.0285272706211349 0.0171680358076466 0.0227184696269765 0 0 0 0 K11636 0.0 0.0227920227920227 yxdM; putative ABC transport system permease protein path:map02020 Two-component system 559.0 11.0 10.0 2.0 0.916666666666667 V 0.0 12.0 2.0 0.916666666666667 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 12.0 0.0 1.0 0.0094391644705796 0.0300568540085386 0.0197480092395591 0.020617689537959 0 0 0 0 K11637 0.0 0.0085470085470085 citS; two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3] path:map02020 Two-component system 511.0 4.0 0.0 1.0 1.0 T 0.0 4.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 4.0 0.0 1.0 0.0047020619249862 0.0186235291057688 0.0116627955153775 0.0139214671807826 0 0 0 0 K11638 0.0028571428571428 0.0056980056980056 K11638, citT; two-component system, CitB family, response regulator CitT path:map02020 Two-component system 213.0 2.0 1.0 2.0 0.666666666666667 KT 1.0 2.0 1.0 1.0 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K11639 0.0 0.0056980056980056 citM; Mg2+/citrate complex secondary transporter path:map02020 Two-component system 435.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2851 Mg2+/citrate_symporter CitM 2.0 0.0 1.0 0 0 0 0 K11641 0.0 0.0056980056980056 natR; two-component system, LytTR family, response regulator NatR path:map02020 Two-component system 210.0 2.0 0.0 1.0 1.0 KT 0.0 2.0 1.0 1.0 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 2.0 0.0 1.0 0 0 0 0 K11645 0.4085714285714286 0.2706552706552707 fbaB; fructose-bisphosphate aldolase, class I [EC:4.1.2.13] path:map00010,path:map00030,path:map00051,path:map00680,path:map00710,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Methane metabolism,Carbon fixation in photosynthetic organisms,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 159.0 201.0 127.0 4.0 0.712765957446808 G 170.0 112.0 1.0 1.0 COG1830 Fructose-bisphosphate_aldolase_class_Ia,_DhnA_family FbaB 282.0 0.6028368794326241 0.3971631205673759 0.564685221929191 0.564658697591158 0.5646719597601746 2.6524338032962724e-05 0 1 0 1 K11646 0.42 0.037037037037037 K11646; 3-dehydroquinate synthase II [EC:1.4.1.24] path:map00400,path:map01100,path:map01110 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 283.0 161.0 0.0 1.0 1.0 E 148.0 13.0 1.0 1.0 COG1465 3-dehydroquinate_synthase,_class_II AroB2 161.0 0.9192546583850932 0.0807453416149068 0.623615454624617 0.0877619424601869 0.3556886985424019 0.5358535121644301 0 1 0 1 K11654 0.0 0.0028490028490028 SMARCA5, SNF2H, ISWI; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [EC:5.6.2.-] 244.0 1.0 0.0 1.0 1.0 KL 0.0 1.0 1.0 1.0 COG0553 Superfamily_II_DNA_or_RNA_helicase,_SNF2_family HepA 1.0 0.0 1.0 0 0 0 0 K11685 0.0 0.0142450142450142 stpA; DNA-binding protein StpA 134.0 5.0 3.0 2.0 0.714285714285714 K 0.0 7.0 1.0 1.0 COG2916 DNA-binding_protein_H-NS Hns 7.0 0.0 1.0 3.89559956628077e-12 1.568317309915e-11 9.789386332715386e-12 1.1787573532869229e-11 0 0 0 0 K11686 0.0 0.0056980056980056 racA; chromosome-anchoring protein RacA 63.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 3.0 0.0 1.0 0 0 0 0 K11688 0.0 0.1282051282051282 dctP; C4-dicarboxylate-binding protein DctP path:map02020 Two-component system 187.0 75.0 0.0 1.0 1.0 G 0.0 75.0 1.0 1.0 COG1638 TRAP-type_C4-dicarboxylate_transport_system,_periplasmic_component DctP 75.0 0.0 1.0 0.0494553971522079 0.0358581174273415 0.0426567572897746 0.0135972797248664 0 0 0 0 K11689 0.0 0.1396011396011396 dctQ; C4-dicarboxylate transporter, DctQ subunit path:map02020 Two-component system 80.0 85.0 0.0 1.0 1.0 G 0.0 85.0 1.0 1.0 COG3090 TRAP-type_C4-dicarboxylate_transport_system,_small_permease_component_YiaM DctM 85.0 0.0 1.0 0.803915879649845 0.634009737656962 0.7189628086534035 0.169906141992883 0 0 1 1 K11690 0.0 0.0968660968660968 dctM; C4-dicarboxylate transporter, DctM subunit path:map02020 Two-component system 399.0 52.0 0.0 1.0 1.0 G 0.0 52.0 1.0 1.0 COG1593 TRAP-type_C4-dicarboxylate_transport_system,_large_permease_component DctQ 52.0 0.0 1.0 0.0101268677828771 0.0597642527718007 0.0349455602773388 0.0496373849889235 0 0 0 0 K11691 0.0 0.017094017094017 K11691, dctS; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3] path:map02020 Two-component system 502.0 9.0 0.0 1.0 1.0 T 0.0 9.0 1.0 1.0 COG3290 Sensor_histidine_kinase_DipB_regulating_citrate/malate_metabolism CitA 9.0 0.0 1.0 0.003092106908422 0.0096692197577256 0.0063806633330738 0.0065771128493036 0 0 0 0 K11692 0.0 0.0284900284900284 K11692, dctR; two-component system, CitB family, response regulator DctR path:map02020 Two-component system 197.0 6.0 1.0 3.0 0.4 K 0.0 15.0 2.0 0.8 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 15.0 0.0 1.0 0.0121399135379876 0.0923930362740652 0.0522664749060264 0.0802531227360776 0 0 0 0 K11693 0.0085714285714285 0.0797720797720797 femX, fmhB; peptidoglycan pentaglycine glycine transferase (the first glycine) [EC:2.3.2.16] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 167.0 34.0 0.0 1.0 1.0 V 4.0 30.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 34.0 0.1176470588235294 0.8823529411764706 0.0523252297603882 0.98950072622484 0.520912977992614 0.9371754964644518 0 0 0 0 K11694 0.0028571428571428 0.0113960113960113 femA; peptidoglycan pentaglycine glycine transferase (the second and third glycine) [EC:2.3.2.17] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 270.0 5.0 0.0 1.0 1.0 V 1.0 4.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 5.0 0.2 0.8 0.0902041704221803 0.840287936683079 0.4652460535526296 0.7500837662608987 0 0 0 0 K11695 0.0028571428571428 0.0113960113960113 femB; peptidoglycan pentaglycine glycine transferase (the fourth and fifth glycine) [EC:2.3.2.18] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 296.0 5.0 0.0 1.0 1.0 V 1.0 4.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 5.0 0.2 0.8 0.0920215357585815 0.847485629467993 0.4697535826132872 0.7554640937094115 0 0 0 0 K11699 0.0085714285714285 0.0 RDR, RDRP; RNA-dependent RNA polymerase [EC:2.7.7.48] 311.0 3.0 0.0 1.0 1.0 P 3.0 0.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 3.0 1.0 0.0 0 0 0 0 K11704 0.0 0.0113960113960113 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein path:map02010 ABC transporters 302.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 4.0 0.0 1.0 1.82340016645483e-07 4.60524988292303e-05 2.311741942293789e-05 4.587015881258482e-05 0 0 0 0 K11705 0.0 0.0256410256410256 mtsC; iron/zinc/manganese/copper transport system permease protein path:map02010 ABC transporters 270.0 8.0 7.0 2.0 0.888888888888889 P 0.0 9.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 9.0 0.0 1.0 0.0224116325651083 0.0282030082712095 0.0253073204181589 0.0057913757061012 0 0 0 0 K11706 0.0 0.0085470085470085 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein path:map02010 ABC transporters 240.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 3.0 0.0 1.0 0 0 0 0 K11707 0.0228571428571428 0.1566951566951566 troA, mntA, znuA; manganese/zinc/iron transport system substrate-binding protein path:map02010 ABC transporters 255.0 66.0 0.0 1.0 1.0 P 8.0 58.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 66.0 0.1212121212121212 0.8787878787878788 0.0220353005592476 0.438979715492963 0.2305075080261053 0.4169444149337153 0 0 0 0 K11708 0.0342857142857142 0.1566951566951566 troC, mntC, znuB; manganese/zinc/iron transport system permease protein path:map02010 ABC transporters 224.0 63.0 58.0 4.0 0.863013698630137 P 14.0 59.0 2.0 0.958904109589041 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 73.0 0.1917808219178082 0.8082191780821918 0.0099122290071433 0.0319467410570086 0.0209294850320759 0.0220345120498653 0 0 0 0 K11709 0.0371428571428571 0.1766381766381766 troD, mntD, znuB; manganese/zinc/iron transport system permease protein path:map02010 ABC transporters 231.0 78.0 75.0 3.0 0.951219512195122 P 15.0 67.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 82.0 0.1829268292682926 0.8170731707317073 0.0460627331321409 0.58756511209487 0.3168139226135054 0.541502378962729 0 0 0 0 K11710 0.0485714285714285 0.1937321937321937 troB, mntB, znuC; manganese/zinc/iron transport system ATP- binding protein [EC:7.2.2.5] path:map02010 ABC transporters 203.0 91.0 89.0 3.0 0.968085106382979 P 17.0 77.0 2.0 0.98936170212766 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 94.0 0.1808510638297872 0.8191489361702128 0.0768821048330502 0.862344854804167 0.4696134798186086 0.7854627499711168 0 0 0 0 K11711 0.0 0.0227920227920227 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3] path:map02020 Two-component system 546.0 9.0 8.0 3.0 0.818181818181818 T 0.0 11.0 5.0 0.545454545454545 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 11.0 0.0 1.0 0.0032291799579845 0.0085739373459008 0.0059015586519426 0.0053447573879163 0 0 0 0 K11712 0.0 0.0341880341880341 dctR; two-component system, LuxR family, response regulator DctR path:map02020 Two-component system 168.0 10.0 5.0 3.0 0.588235294117647 K 0.0 17.0 2.0 0.529411764705882 COG4565 DNA-binding_response_regulator_DpiB_of_citrate/malate_metabolism CitB 17.0 0.0 1.0 0.0064671911165339 0.0179258666144541 0.012196528865494 0.0114586754979202 0 0 0 0 K11717 0.6628571428571428 0.6780626780626781 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] path:map00450,path:map01100 Selenocompound metabolism,Metabolic pathways 226.0 554.0 539.0 5.0 0.950257289879931 E 312.0 271.0 4.0 0.97598627787307 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 583.0 0.5351629502572899 0.4648370497427101 0.000527133026312 0.0107018805077012 0.0056145067670066 0.0101747474813891 0 0 0 0 K11719 0.0 0.2222222222222222 lptC; lipopolysaccharide export system protein LptC 31.0 60.0 43.0 3.0 0.769230769230769 S 0.0 78.0 2.0 0.641025641025641 COG3117 Lipopolysaccharide_export_system_protein_LptC YrbK 78.0 0.0 1.0 0.0047749591828847 0.0109043383137708 0.0078396487483277 0.0061293791308861 0 0 0 0 K11720 0.0 0.584045584045584 lptG; lipopolysaccharide export system permease protein path:map02010 ABC transporters 78.0 213.0 179.0 2.0 0.862348178137652 S 0.0 247.0 1.0 1.0 COG0795 Lipopolysaccharide_export_LptBFGC_system,_permease_protein_LptF LptF 247.0 0.0 1.0 0.0163661058579175 0.0358520149570146 0.026109060407466 0.0194859090990971 0 0 0 0 K11729 0.0028571428571428 0.0028490028490028 ACAD10; acyl-CoA dehydrogenase family member 10 298.0 1.0 0.0 2.0 0.5 S 1.0 1.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 2.0 0.5 0.5 0 0 0 0 K11731 0.0 0.0569800569800569 atuD; citronellyl-CoA dehydrogenase [EC:1.3.99.-] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 359.0 17.0 5.0 2.0 0.586206896551724 C 0.0 29.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 29.0 0.0 1.0 0.0324583781999265 0.190057669139677 0.1112580236698017 0.1575992909397505 0 0 0 0 K11732 0.0 0.0142450142450142 pheP; phenylalanine-specific permease 442.0 5.0 4.0 3.0 0.714285714285714 E 0.0 7.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 7.0 0.0 1.0 0.0228341548419 0.0575647215700781 0.040199438205989 0.0347305667281781 0 0 0 0 K11733 0.0 0.0655270655270655 lysP; lysine-specific permease 463.0 27.0 0.0 1.0 1.0 E 0.0 27.0 1.0 1.0 COG0833 Amino_acid_permease LysP 27.0 0.0 1.0 0.0161237732899712 0.0301656435458404 0.0231447084179058 0.0140418702558691 0 0 0 0 K11734 0.0 0.0341880341880341 aroP; aromatic amino acid transport protein AroP 437.0 12.0 11.0 3.0 0.857142857142857 E 0.0 14.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 14.0 0.0 1.0 0.0716300151195864 0.0743825635303224 0.0730062893249544 0.0027525484107359 0 0 0 0 K11735 0.0 0.0512820512820512 gabP; GABA permease 432.0 23.0 0.0 1.0 1.0 E 0.0 23.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 23.0 0.0 1.0 0.0256793131967912 0.0680300898386321 0.0468547015177116 0.0423507766418408 0 0 0 0 K11736 0.0 0.0113960113960113 proY; proline-specific permease ProY 436.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 4.0 0.0 1.0 0.0122678487651665 0.0563002029024286 0.0342840258337975 0.0440323541372621 0 0 0 0 K11737 0.0057142857142857 0.0626780626780626 cycA; D-serine/D-alanine/glycine transporter 418.0 33.0 0.0 1.0 1.0 E 2.0 31.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 33.0 0.0606060606060606 0.9393939393939394 0.0124304558793703 0.0268947184576624 0.0196625871685163 0.014464262578292 0 0 0 0 K11738 0.0 0.0341880341880341 ansP; L-asparagine permease 449.0 18.0 0.0 1.0 1.0 E 0.0 18.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 18.0 0.0 1.0 0.0202664634534385 0.0517743146598083 0.0360203890566234 0.0315078512063698 0 0 0 0 K11739 0.0 0.0113960113960113 nfrA; bacteriophage N4 adsorption protein A 105.0 2.0 1.0 3.0 0.5 L 0.0 4.0 2.0 0.75 COG4783 Outer_membrane_protein_chaperone/metalloprotease_BepA/YfgC,_contains_M48_and_TPR_domains BepA 4.0 0.0 1.0 0.218987383196171 0.384563986417704 0.3017756848069375 0.165576603221533 0 0 0 0 K11740 0.0 0.0256410256410256 nfrB; bacteriophage N4 adsorption protein B 535.0 10.0 0.0 1.0 1.0 M 0.0 10.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 10.0 0.0 1.0 0.0815873324039448 0.163209775361843 0.1223985538828939 0.0816224429578982 0 0 0 0 K11741 0.1 0.2592592592592592 sugE; quaternary ammonium compound-resistance protein SugE 97.0 133.0 102.0 2.0 0.810975609756098 P 50.0 114.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 164.0 0.3048780487804878 0.6951219512195121 0.0181598290290379 0.0592024619784404 0.0386811455037391 0.0410426329494025 0 0 0 0 K11742 0.0 0.017094017094017 mdtI; spermidine export protein MdtI 104.0 4.0 2.0 2.0 0.666666666666667 P 0.0 6.0 2.0 0.833333333333333 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 6.0 0.0 1.0 0.0449861978062367 0.0864517413925446 0.0657189695993906 0.0414655435863079 0 0 0 0 K11743 0.0 0.0113960113960113 mdtJ; spermidine export protein MdtJ 112.0 3.0 2.0 2.0 0.75 P 0.0 4.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 4.0 0.0 1.0 4.13376144314367e-12 2.97457058405198e-08 1.4874919800981473e-08 2.9741572079076652e-08 0 0 0 0 K11744 0.0314285714285714 0.0484330484330484 tqsA; AI-2 transport protein TqsA 248.0 22.0 17.0 3.0 0.758620689655172 S 11.0 18.0 1.0 1.0 COG0628 Predicted_PurR-regulated_permease_PerM PerM 29.0 0.3793103448275862 0.6206896551724138 0.0899970400885175 0.0525036548255968 0.0712503474570571 0.0374933852629206 0 0 0 0 K11745 0.0 0.0569800569800569 kefC; glutathione-regulated potassium-efflux system ancillary protein KefC 369.0 25.0 0.0 1.0 1.0 P 0.0 25.0 2.0 0.96 COG0475 Kef-type_K+_transport_system,_membrane_component_KefB KefB 25.0 0.0 1.0 0.0267135471572339 0.0685296418546446 0.0476215945059392 0.0418160946974107 0 0 0 0 K11746 0.0 0.0113960113960113 kefF; glutathione-regulated potassium-efflux system ancillary protein KefF 166.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG2249 Putative_NADPH-quinone_reductase_(modulator_of_drug_activity_B) MdaB 4.0 0.0 1.0 0.0394230586426683 0.0940741868831859 0.0667486227629271 0.0546511282405176 0 0 0 0 K11747 0.0085714285714285 0.150997150997151 kefB; glutathione-regulated potassium-efflux system protein KefB 431.0 67.0 0.0 1.0 1.0 P 3.0 64.0 3.0 0.91044776119403 COG0475 Kef-type_K+_transport_system,_membrane_component_KefB KefB 67.0 0.044776119402985 0.9552238805970148 0.0161677964554824 0.0362348921561175 0.0262013443057999 0.0200670957006351 0 0 0 0 K11748 0.0 0.0797720797720797 kefG; glutathione-regulated potassium-efflux system ancillary protein KefG 145.0 29.0 26.0 2.0 0.90625 S 0.0 33.0 2.0 0.96969696969697 COG2249 Putative_NADPH-quinone_reductase_(modulator_of_drug_activity_B) MdaB 33.0 0.0 1.0 0.0199487951879037 0.0394355645355692 0.0296921798617364 0.0194867693476654 0 0 0 0 K11749 0.0057142857142857 0.9230769230769232 rseP; regulator of sigma E protease [EC:3.4.24.-] path:map04112 Cell cycle - Caulobacter 122.0 344.0 0.0 1.0 1.0 M 3.0 341.0 4.0 0.98546511627907 COG0750 Membrane-associated_protease_RseP,_regulator_of_RpoE_activity RseP 344.0 0.0087209302325581 0.9912790697674418 0.0918296647857527 0.425161783451049 0.2584957241184008 0.3333321186652963 0 0 0 0 K11750 0.0 0.0284900284900284 frsA; esterase FrsA [EC:3.1.-.-] 322.0 7.0 5.0 3.0 0.7 S 0.0 10.0 2.0 0.7 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 10.0 0.0 1.0 0.0225473358325974 0.0516399459327797 0.0370936408826885 0.0290926101001823 0 0 0 0 K11751 0.0771428571428571 0.3475783475783476 ushA; 5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45] path:map00230,path:map00240,path:map00760,path:map01100,path:map01110,path:map01232 Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 60.0 174.0 166.0 10.0 0.874371859296482 F 32.0 167.0 8.0 0.864321608040201 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 199.0 0.1608040201005025 0.8391959798994975 0.579954431662073 0.870263730259242 0.7251090809606575 0.290309298597169 0 1 0 1 K11752 0.08 0.7977207977207977 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] path:map00740,path:map01100,path:map01110,path:map01240,path:map02024 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors,Quorum sensing 163.0 335.0 332.0 2.0 0.99112426035503 H 28.0 310.0 3.0 0.911242603550296 COG0117 Riboflavin_biosynthesis_protein_RibD,_pyrimidine_deaminase_domain RibD1 338.0 0.0828402366863905 0.9171597633136096 0.104391683363867 0.462810303089137 0.283600993226502 0.35841861972527 0 0 0 0 K11753 0.0 0.905982905982906 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 130.0 329.0 326.0 3.0 0.987987987987988 H 0.0 333.0 3.0 0.990990990990991 COG0196 FAD_synthase RibF 333.0 0.0 1.0 0.0265781390279094 0.191994039182335 0.1092860891051222 0.1654159001544256 0 0 0 0 K11754 0.1914285714285714 0.8945868945868946 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 107.0 408.0 402.0 2.0 0.985507246376812 H 69.0 345.0 3.0 0.961352657004831 COG0285 Folylpolyglutamate_synthase/Dihydropteroate_synthase FolC 414.0 0.1666666666666666 0.8333333333333334 0.0520791698978109 0.0158497961082553 0.0339644830030331 0.0362293737895556 0 0 0 0 K11755 0.1342857142857142 0.6296296296296297 hisIE; phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase [EC:3.5.4.19 3.6.1.31] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 63.0 300.0 295.0 2.0 0.983606557377049 E 53.0 235.0 5.0 0.914754098360656 COG0139 Phosphoribosyl-AMP_cyclohydrolase HisI1 288.0 0.1840277777777778 0.8159722222222222 0.141855197705562 0.481054102363308 0.3114546500344349 0.339198904657746 0 0 0 0 K11763 0.0028571428571428 0.0 RSC9; chromatin structure-remodeling complex subunit RSC9 169.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 KOG2744 1.0 1.0 0.0 0 0 0 0 K11777 0.0028571428571428 0.0512820512820512 K11777; HAD superfamily phosphatase 188.0 19.0 0.0 1.0 1.0 S 1.0 18.0 1.0 1.0 COG0546 Phosphoglycolate_phosphatase,_HAD_superfamily Gph 19.0 0.0526315789473684 0.9473684210526316 0.004372086809531 0.0087896042249463 0.0065808455172386 0.0044175174154153 0 0 0 0 K11779 0.0428571428571428 0.1566951566951566 fbiC; FO synthase [EC:2.5.1.147 4.3.1.32] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 303.0 95.0 0.0 1.0 1.0 H 17.0 74.0 1.0 1.0 COG1060 2-iminoacetate_synthase_ThiH/Menaquinone_biosynthesis_enzymes_MqnC_and_MqnE ThiH 91.0 0.1868131868131868 0.8131868131868132 0.0218689001036172 0.127315426372028 0.0745921632378226 0.1054465262684108 0 0 0 0 K11780 0.3342857142857143 0.0712250712250712 cofG; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase [EC:4.3.1.32] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 234.0 152.0 151.0 2.0 0.993464052287582 H 118.0 35.0 2.0 0.986928104575163 COG1060 2-iminoacetate_synthase_ThiH/Menaquinone_biosynthesis_enzymes_MqnC_and_MqnE ThiH 153.0 0.7712418300653595 0.2287581699346405 0.242189872748072 0.20064642824292 0.221418150495496 0.0415434445051519 0 0 0 0 K11781 0.3571428571428571 0.0712250712250712 cofH; 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase [EC:2.5.1.147] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 305.0 174.0 0.0 1.0 1.0 H 139.0 35.0 1.0 1.0 COG1060 2-iminoacetate_synthase_ThiH/Menaquinone_biosynthesis_enzymes_MqnC_and_MqnE ThiH 174.0 0.7988505747126436 0.2011494252873563 0.667331988998743 0.941190801767073 0.8042613953829081 0.27385881276833 0 1 0 1 K11782 0.1142857142857142 0.2193732193732193 mqnA; chorismate dehydratase [EC:4.2.1.151] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 103.0 71.0 32.0 3.0 0.581967213114754 S 42.0 80.0 2.0 0.959016393442623 COG1427 Chorismate_dehydratase_(menaquinone_biosynthesis,_futalosine_pathway) MqnA 122.0 0.3442622950819672 0.6557377049180327 0.0724003370654755 0.713696328814314 0.3930483329398947 0.6412959917488386 0 0 0 0 K11783 0.0114285714285714 0.1111111111111111 mqnB; futalosine hydrolase [EC:3.2.2.26] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 124.0 44.0 0.0 1.0 1.0 F 4.0 40.0 1.0 1.0 COG0775 Nucleoside_phosphorylase/nucleosidase,_includes_5'-methylthioadenosine/S-adenosylhomocysteine_nucleosidase_MtnN_and_futalosine_hydrolase_MqnB MtnN 44.0 0.0909090909090909 0.9090909090909092 0.270360740729144 0.158994984137846 0.214677862433495 0.111365756591298 0 0 0 0 K11784 0.0657142857142857 0.2108262108262108 mqnC; cyclic dehypoxanthinyl futalosine synthase [EC:1.21.98.1] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 274.0 110.0 101.0 4.0 0.846153846153846 H 23.0 107.0 2.0 0.907692307692308 COG1060 2-iminoacetate_synthase_ThiH/Menaquinone_biosynthesis_enzymes_MqnC_and_MqnE ThiH 130.0 0.1769230769230769 0.823076923076923 0.0349877827442014 0.0785968938201163 0.0567923382821588 0.0436091110759149 0 0 0 0 K11785 0.1742857142857143 0.1766381766381766 mqnD; 1,4-dihydroxy-6-naphthoate synthase [EC:1.14.-.-] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 200.0 64.0 1.0 2.0 0.503937007874016 S 65.0 62.0 1.0 1.0 COG2107 1,4-dihydroxy-6-naphtoate_synthase_(menaquinone_biosynthesis,_futalosine_pathway) MqnD 127.0 0.5118110236220472 0.4881889763779528 0.0776429570307702 0.0388186689085412 0.0582308129696557 0.038824288122229 0 0 0 0 K11787 0.0114285714285714 0.0113960113960113 GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1] path:map00230,path:map00670,path:map01100,path:map01110,path:map01523 Purine metabolism,One carbon pool by folate,Metabolic pathways,Biosynthesis of secondary metabolites,Antifolate resistance 173.0 8.0 0.0 1.0 1.0 F 4.0 4.0 1.0 1.0 COG0151 Phosphoribosylamine-glycine_ligase PurD 8.0 0.5 0.5 0.119220624741894 0.193346294366335 0.1562834595541145 0.0741256696244409 0 0 0 0 K11788 0.06 0.1225071225071225 ADE5; phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 6.3.3.1] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 213.0 64.0 0.0 1.0 1.0 F 21.0 43.0 2.0 0.640625 COG0151 Phosphoribosylamine-glycine_ligase PurD 64.0 0.328125 0.671875 0.011661419455371 0.023273379711668 0.0174673995835194 0.0116119602562969 0 0 0 0 K11806 0.0028571428571428 0.0 DCAF13, WDSOF1; DDB1- and CUL4-associated factor 13 308.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 KOG0268 1.0 1.0 0.0 0 0 0 0 K11808 0.0 0.0028490028490028 ADE2; phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 165.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 COG0152 Phosphoribosylaminoimidazole-succinocarboxamide_synthase PurC 1.0 0.0 1.0 0 0 0 0 K11811 0.0 0.0769230769230769 arsH; arsenical resistance protein ArsH 204.0 31.0 0.0 1.0 1.0 S 0.0 31.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 31.0 0.0 1.0 0.0064455433228233 0.0156711484108594 0.0110583458668413 0.0092256050880361 0 0 0 0 K11814 0.0 0.0085470085470085 ebrA; multidrug resistance protein EbrA 107.0 3.0 0.0 2.0 0.5 P 0.0 6.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 6.0 0.0 1.0 0.0060887727409468 0.0149958843604081 0.0105423285506774 0.0089071116194613 0 0 0 0 K11815 0.0 0.0085470085470085 ebrB; multidrug resistance protein EbrB 107.0 3.0 1.0 2.0 0.6 P 0.0 5.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 5.0 0.0 1.0 2.59834444315213e-07 0.0012363196424249 0.0006182897384346 0.0012360598079805 0 0 0 0 K11816 0.0 0.0085470085470085 YUCCA; indole-3-pyruvate monooxygenase [EC:1.14.13.168] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 323.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 3.0 0.0 1.0 0 0 0 0 K11822 0.0 0.0028490028490028 SULT2A; bile-salt sulfotransferase [EC:2.8.2.14] path:map00980,path:map04976,path:map05204 Metabolism of xenobiotics by cytochrome P450,Bile secretion,Chemical carcinogenesis - DNA adducts 253.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG1584 1.0 0.0 1.0 0 0 0 0 K11840 0.0 0.0028490028490028 USP9_24; ubiquitin carboxyl-terminal hydrolase 9/24 [EC:3.4.19.12] 565.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG5077 1.0 0.0 1.0 0 0 0 0 K11849 0.0 0.0028490028490028 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12] path:map04657 IL-17 signaling pathway 565.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG5077 1.0 0.0 1.0 0 0 0 0 K11853 0.0 0.0028490028490028 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12] 565.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG5077 1.0 0.0 1.0 0 0 0 0 K11855 0.0 0.0028490028490028 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12] 445.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 KOG1865 1.0 0.0 1.0 0 0 0 0 K11866 0.0028571428571428 0.0 STAMBP, AMSH; STAM-binding protein [EC:3.4.19.12] path:map04144 Endocytosis 289.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG1310 Proteasome_lid_subunit_RPN8/RPN11,_contains_Jab1/MPN_domain_metalloenzyme_(JAMM)_motif Rri1 1.0 1.0 0.0 0 0 0 0 K11884 0.0028571428571428 0.0 PNO1, DIM2; RNA-binding protein PNO1 161.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG1094 rRNA_processing_protein_Krr1/Pno1,_contains_KH_domain Krr1 1.0 1.0 0.0 0 0 0 0 K11887 0.0028571428571428 0.0 PAAF1, RPN14; proteasomal ATPase-associated factor 1 382.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG4155 1.0 1.0 0.0 0 0 0 0 K11889 0.0 0.0028490028490028 impN; type VI secretion system protein ImpN [EC:2.7.11.1] 307.0 1.0 0.0 1.0 1.0 KLT 0.0 1.0 1.0 1.0 COG0515 Serine/threonine_protein_kinase SPS1 1.0 0.0 1.0 0 0 0 0 K11890 0.0 0.0313390313390313 impM; type VI secretion system protein ImpM path:map02025 Biofilm formation - Pseudomonas aeruginosa 169.0 7.0 2.0 2.0 0.583333333333333 S 0.0 12.0 2.0 0.833333333333333 COG3913 Regulator_of_T6SS_expression_TagF,_TagF/ImpM/SciT_family_(unrelated_to_teichoic_acid_polymerase_TagF_of_B.subtilis,_COG1887) SciT 12.0 0.0 1.0 0.0282877079590077 0.0492915443672464 0.038789626163127 0.0210038364082387 0 0 0 0 K11891 0.0 0.0854700854700854 impL, vasK, icmF; type VI secretion system protein ImpL path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 207.0 29.0 26.0 4.0 0.852941176470588 S 0.0 38.0 6.0 0.736842105263158 COG3523 Type_VI_protein_secretion_system_component_VasK IcmF 38.0 0.0 1.0 0.0157822690347849 0.0381986713836227 0.0269904702092038 0.0224164023488378 0 0 0 0 K11892 0.0028571428571428 0.0769230769230769 impK, ompA, vasF, dotU; type VI secretion system protein ImpK path:map03070 Bacterial secretion system 134.0 16.0 1.0 2.0 0.516129032258065 N 1.0 30.0 2.0 0.612903225806452 COG3455 Type_VI_protein_secretion_system_component_TssL/VasF/DotU DotU 31.0 0.032258064516129 0.967741935483871 0.0415898077098339 0.0481452087325097 0.0448675082211718 0.0065554010226758 0 0 0 0 K11893 0.0028571428571428 0.0769230769230769 impJ, vasE; type VI secretion system protein ImpJ path:map02025 Biofilm formation - Pseudomonas aeruginosa 305.0 32.0 0.0 1.0 1.0 S 1.0 31.0 1.0 1.0 COG3522 Predicted_component_of_the_type_VI_protein_secretion_system 32.0 0.03125 0.96875 0.0216960412093322 0.079952654285023 0.0508243477471776 0.0582566130756908 0 0 0 0 K11894 0.0 0.0598290598290598 impI, vasC; type VI secretion system protein ImpI 47.0 26.0 24.0 3.0 0.896551724137931 T 0.0 29.0 3.0 0.896551724137931 COG1716 Forkhead_associated_(FHA)_domain,_binds_pSer,_pThr,_pTyr FHA 29.0 0.0 1.0 0.0038293403854928 0.0081196792536376 0.0059745098195652 0.0042903388681448 0 0 0 0 K11895 0.0 0.0712250712250712 impH, vasB; type VI secretion system protein ImpH path:map02025 Biofilm formation - Pseudomonas aeruginosa 228.0 26.0 0.0 1.0 1.0 S 0.0 26.0 1.0 1.0 COG3520 Predicted_component_of_the_type_VI_protein_secretion_system 26.0 0.0 1.0 0.0240085173676152 0.0568190654961068 0.040413791431861 0.0328105481284916 0 0 0 0 K11896 0.0 0.0826210826210826 impG, vasA; type VI secretion system protein ImpG 410.0 30.0 0.0 1.0 1.0 S 0.0 30.0 1.0 1.0 COG3519 Type_VI_protein_secretion_system_component_VasA VasA 30.0 0.0 1.0 0.0240623951663614 0.0662766812323178 0.0451695381993395 0.0422142860659564 0 0 0 0 K11897 0.0 0.0541310541310541 impF; type VI secretion system protein ImpF 111.0 19.0 0.0 1.0 1.0 S 0.0 19.0 1.0 1.0 COG3518 Predicted_component_of_the_type_VI_protein_secretion_system 19.0 0.0 1.0 0.0202140260265013 0.0433520449528211 0.0317830354896612 0.0231380189263198 0 0 0 0 K11898 0.0 0.0341880341880341 impE; type VI secretion system protein ImpE 218.0 12.0 0.0 1.0 1.0 S 0.0 12.0 1.0 1.0 COG4455 Protein_of_avirulence_locus_involved_in_temperature-dependent_protein_secretion ImpE 12.0 0.0 1.0 0.0339864732477088 0.0559448526805883 0.0449656629641485 0.0219583794328794 0 0 0 0 K11899 0.0 0.0085470085470085 impD; type VI secretion system protein ImpD 435.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3517 Predicted_component_TssB_of_the_type_VI_protein_secretion_system,_VipA/VipB/TssB_family 3.0 0.0 1.0 0 0 0 0 K11900 0.0 0.0797720797720797 impC; type VI secretion system protein ImpC path:map02025 Biofilm formation - Pseudomonas aeruginosa 442.0 35.0 34.0 2.0 0.972222222222222 S 0.0 36.0 2.0 0.916666666666667 COG3517 Predicted_component_TssB_of_the_type_VI_protein_secretion_system,_VipA/VipB/TssB_family 36.0 0.0 1.0 0.0149774187449012 0.0354146021383645 0.0251960104416328 0.0204371833934632 0 0 0 0 K11901 0.0 0.074074074074074 impB; type VI secretion system protein ImpB path:map02025 Biofilm formation - Pseudomonas aeruginosa 146.0 26.0 25.0 2.0 0.962962962962963 S 0.0 27.0 1.0 1.0 COG3516 Predicted_component_TssA_of_the_type_VI_protein_secretion_system TssB 27.0 0.0 1.0 0.0191993140208207 0.0382373815144654 0.028718347767643 0.0190380674936447 0 0 0 0 K11902 0.0 0.0598290598290598 impA; type VI secretion system protein ImpA path:map02025 Biofilm formation - Pseudomonas aeruginosa 229.0 19.0 17.0 2.0 0.904761904761905 S 0.0 21.0 1.0 1.0 COG3515 Type_VI_protein_secretion_system_component_TssA1/VasJ/EvfE,_contains_ImpA_N_domain TssA1 21.0 0.0 1.0 0.0226952181288952 0.0440613283244363 0.0333782732266657 0.0213661101955411 0 0 0 0 K11903 0.0114285714285714 0.0826210826210826 hcp; type VI secretion system secreted protein Hcp path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 94.0 39.0 0.0 1.0 1.0 S 4.0 35.0 1.0 1.0 COG3157 Type_VI_protein_secretion_system_component_Hcp_(secreted_cytotoxin) Hcp 39.0 0.1025641025641025 0.8974358974358975 0.0171666070747435 0.0674986610768934 0.0423326340758184 0.0503320540021498 0 0 0 0 K11904 0.0057142857142857 0.1339031339031339 vgrG; type VI secretion system secreted protein VgrG path:map03070 Bacterial secretion system 61.0 44.0 35.0 11.0 0.517647058823529 S 2.0 83.0 14.0 0.662790697674419 COG3501 Uncharacterized_conserved_protein_VgrG,_implicated_in_type_VI_secretion_and_phage_assembly VgrG 85.0 0.0235294117647058 0.976470588235294 0.005512569365431 0.0143408876269143 0.0099267284961726 0.0088283182614833 0 0 0 0 K11905 0.0 0.0256410256410256 K11905; type VI secretion system protein 117.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 COG3518 Predicted_component_of_the_type_VI_protein_secretion_system 9.0 0.0 1.0 0.0338845890277542 0.0604095878247542 0.0471470884262542 0.026524998797 0 0 0 0 K11906 0.0028571428571428 0.0313390313390313 vasD, lip; type VI secretion system protein VasD path:map03070 Bacterial secretion system 127.0 13.0 12.0 2.0 0.928571428571429 S 1.0 13.0 1.0 1.0 COG3521 Predicted_component_of_the_type_VI_protein_secretion_system 14.0 0.0714285714285714 0.9285714285714286 0.0533329420882061 0.0699384957419516 0.0616357189150788 0.0166055536537454 0 0 0 0 K11907 0.0 0.074074074074074 vasG, clpV; type VI secretion system protein VasG path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 791.0 28.0 0.0 1.0 1.0 O 0.0 28.0 1.0 1.0 COG0542 ATP-dependent_Clp_protease,_ATP-binding_subunit_ClpA ClpA 28.0 0.0 1.0 0.0350785373773909 0.0774911999088258 0.0562848686431083 0.0424126625314349 0 0 0 0 K11908 0.0 0.0113960113960113 vasH; sigma-54 dependent transcriptional regulator 234.0 4.0 1.0 3.0 0.444444444444444 KT 0.0 9.0 2.0 0.666666666666667 COG3829 RocR-type_transcriptional_regulator,_contains_PAS,_AAA-type_ATPase,_and_DNA-binding_Fis_domains RocR 9.0 0.0 1.0 0.0066861350522589 0.0145882739766441 0.0106372045144515 0.0079021389243852 0 0 0 0 K11909 0.0 0.0085470085470085 vasI; type VI secretion system protein VasI 165.0 2.0 0.0 1.0 1.0 S 0.0 3.0 3.0 0.333333333333333 28PTC 3.0 0.0 1.0 0 0 0 0 K11910 0.0 0.0313390313390313 vasJ; type VI secretion system protein VasJ 363.0 7.0 3.0 3.0 0.583333333333333 S 0.0 12.0 2.0 0.916666666666667 COG3515 Type_VI_protein_secretion_system_component_TssA1/VasJ/EvfE,_contains_ImpA_N_domain TssA1 12.0 0.0 1.0 0.0448808413446191 0.0996524185289963 0.0722666299368077 0.0547715771843771 0 0 0 0 K11911 0.0 0.0028490028490028 vasL; type VI secretion system protein VasL 466.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3515 Type_VI_protein_secretion_system_component_TssA1/VasJ/EvfE,_contains_ImpA_N_domain TssA1 1.0 0.0 1.0 0 0 0 0 K11912 0.0028571428571428 0.0512820512820512 ppkA; serine/threonine-protein kinase PpkA [EC:2.7.11.1] path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 102.0 10.0 4.0 5.0 0.37037037037037 KLT 1.0 25.0 6.0 0.37037037037037 COG0515 Serine/threonine_protein_kinase SPS1 26.0 0.0384615384615384 0.9615384615384616 0 0 0 0 K11913 0.0028571428571428 0.0256410256410256 fha1; type VI secretion system protein path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 96.0 11.0 0.0 1.0 1.0 T 1.0 10.0 2.0 0.909090909090909 COG1716 Forkhead_associated_(FHA)_domain,_binds_pSer,_pThr,_pTyr FHA 11.0 0.0909090909090909 0.9090909090909092 0.0234105110684201 0.0585689209539511 0.0409897160111856 0.035158409885531 0 0 0 0 K11914 0.0028571428571428 0.0341880341880341 sfa2; sigma-54 dependent transcriptional regulator 284.0 12.0 5.0 2.0 0.631578947368421 KT 1.0 18.0 4.0 0.68421052631579 COG3829 RocR-type_transcriptional_regulator,_contains_PAS,_AAA-type_ATPase,_and_DNA-binding_Fis_domains RocR 19.0 0.0526315789473684 0.9473684210526316 0.0094627022415363 0.0259290030071615 0.0176958526243489 0.0164663007656252 0 0 0 0 K11915 0.0 0.0028490028490028 stp1, pppA; serine/threonine protein phosphatase Stp1 [EC:3.1.3.16] path:map02025,path:map03070 Biofilm formation - Pseudomonas aeruginosa,Bacterial secretion system 256.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0631 Serine/threonine_protein_phosphatase_PrpC PTC1 1.0 0.0 1.0 0 0 0 0 K11916 0.0 0.0113960113960113 stk1; serine/threonine-protein kinase Stk1 [EC:2.7.11.-] 281.0 5.0 0.0 1.0 1.0 KLT 0.0 5.0 1.0 1.0 COG0515 Serine/threonine_protein_kinase SPS1 5.0 0.0 1.0 0 0 0 0 K11918 0.0 0.0056980056980056 lip3; type VI secretion system protein 150.0 0.0 2.0 1.0 1.0 2E53M 2.0 0.0 1.0 0 0 0 0 K11920 0.0 0.0028490028490028 envY; AraC family transcriptional regulator 253.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K11921 0.0 0.0683760683760683 cynR; LysR family transcriptional regulator, cyn operon transcriptional activator 216.0 29.0 0.0 1.0 1.0 K 0.0 29.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 29.0 0.0 1.0 0.0060209458983862 0.0122082284166744 0.0091145871575303 0.0061872825182881 0 0 0 0 K11922 0.0 0.0142450142450142 mngR, farR; GntR family transcriptional regulator, mannosyl-D-glycerate transport/metabolism system repressor 212.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG2188 DNA-binding_transcriptional_regulator,_GntR_family MngR 7.0 0.0 1.0 3.12007588046969e-12 0.031344268289928 0.015672134146524 0.0313442682868079 0 0 0 0 K11923 0.0 0.037037037037037 cueR; MerR family transcriptional regulator, copper efflux regulator 93.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 14.0 0.0 1.0 0.0322111226190067 0.145717830524721 0.0889644765718638 0.1135067079057143 0 0 0 0 K11924 0.1571428571428571 0.0712250712250712 mntR; DtxR family transcriptional regulator, manganese transport regulator 59.0 99.0 0.0 1.0 1.0 K 67.0 32.0 2.0 0.666666666666667 COG3432 Predicted_transcriptional_regulator 99.0 0.6767676767676768 0.3232323232323232 0.185212882729286 0.585090528491173 0.3851517056102295 0.399877645761887 0 0 0 0 K11925 0.0 0.0113960113960113 sgrR; SgrR family transcriptional regulator 547.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG4533 DNA-binding_transcriptional_regulator_SgrR_of_sgrS_sRNA,_contains_a_MarR-type_HTH_domain_and_a_periplasmic-type_solute-binding_domain SgrR 4.0 0.0 1.0 1.85982401457858e-12 1.72383705315073e-08 8.620115177760939e-09 1.7236510707492723e-08 0 0 0 0 K11926 0.0 0.0085470085470085 crl; sigma factor-binding protein Crl 88.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 292QM 3.0 0.0 1.0 0 0 0 0 K11927 0.2428571428571428 0.5698005698005698 rhlE; ATP-dependent RNA helicase RhlE [EC:3.6.4.13] path:map03018 RNA degradation 225.0 312.0 222.0 3.0 0.762836185819071 L 103.0 306.0 2.0 0.997555012224939 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 409.0 0.2518337408312958 0.7481662591687042 0.491105865024162 0.406139463610178 0.44862266431717 0.0849664014139839 0 0 0 0 K11928 0.1885714285714285 0.2307692307692307 putP; sodium/proline symporter 308.0 189.0 187.0 4.0 0.979274611398964 E 94.0 99.0 3.0 0.984455958549223 COG0591 Na+/proline_symporter PutP 193.0 0.4870466321243523 0.5129533678756477 0.410130312379422 0.641441840112796 0.5257860762461091 0.231311527733374 0 0 0 0 K11929 0.0 0.0085470085470085 phoE; outer membrane pore protein E 289.0 11.0 0.0 1.0 1.0 M 0.0 11.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 11.0 0.0 1.0 0.0017213194347058 0.002863676827662 0.0022924981311839 0.0011423573929562 0 0 0 0 K11930 0.0 0.017094017094017 torT; periplasmic protein TorT 321.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 6.0 0.0 1.0 0.0628124423476675 0.262520590804332 0.1626665165759997 0.1997081484566644 0 0 0 0 K11931 0.0171428571428571 0.0968660968660968 pgaB; poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase [EC:3.5.1.-] path:map02026 Biofilm formation - Escherichia coli 14.0 21.0 4.0 4.0 0.456521739130435 G 6.0 40.0 3.0 0.5 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 46.0 0.1304347826086956 0.8695652173913043 0.499993953974478 0.417524964519747 0.4587594592471125 0.0824689894547309 0 0 0 0 K11932 0.0 0.0199430199430199 uspG; universal stress protein G 127.0 6.0 3.0 2.0 0.666666666666667 T 0.0 9.0 2.0 0.666666666666667 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 9.0 0.0 1.0 0.0110168624747303 0.026366667208239 0.0186917648414846 0.0153498047335086 0 0 0 0 K11933 0.0028571428571428 0.0113960113960113 hcr; NADH oxidoreductase Hcr [EC:1.-.-.-] 96.0 5.0 0.0 1.0 1.0 C 1.0 4.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 5.0 0.2 0.8 0.0602414650399467 0.105772759263735 0.0830071121518408 0.0455312942237883 0 0 0 0 K11934 0.0 0.0085470085470085 ompX; outer membrane protein X 133.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 4.0 0.0 1.0 2.40621171981634e-12 3.5692269376183e-09 1.785816574669058e-09 3.5668207258984833e-09 0 0 0 0 K11935 0.0 0.0427350427350427 pgaA; biofilm PGA synthesis protein PgaA path:map02026 Biofilm formation - Escherichia coli 231.0 5.0 1.0 5.0 0.333333333333333 L 0.0 15.0 3.0 0.8 COG0457 Tetratricopeptide_(TPR)_repeat TPR 15.0 0.0 1.0 0.142033431456344 0.600320106334521 0.3711767688954325 0.458286674878177 0 0 0 0 K11936 0.1057142857142857 0.1025641025641025 pgaC, icaA; poly-beta-1,6-N-acetyl-D-glucosamine synthase [EC:2.4.1.-] path:map00543,path:map02026 Exopolysaccharide biosynthesis,Biofilm formation - Escherichia coli 70.0 85.0 83.0 2.0 0.977011494252874 M 40.0 47.0 2.0 0.931034482758621 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 87.0 0.4597701149425287 0.5402298850574713 0.142559897272752 0.367558783555896 0.255059340414324 0.224998886283144 0 0 0 0 K11937 0.0 0.0227920227920227 pgaD; biofilm PGA synthesis protein PgaD path:map00543,path:map02026 Exopolysaccharide biosynthesis,Biofilm formation - Escherichia coli 123.0 6.0 4.0 2.0 0.75 S 0.0 8.0 5.0 0.375 2E6EV 8.0 0.0 1.0 0.0621983182022602 0.144689708801389 0.1034440135018246 0.0824913905991288 0 0 0 0 K11938 0.0 0.0056980056980056 cof; HMP-PP phosphatase [EC:3.6.1.-] 245.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 2.0 0.0 1.0 0 0 0 0 K11939 0.0 0.0968660968660968 rhtA; inner membrane transporter RhtA 250.0 44.0 41.0 2.0 0.936170212765957 S 0.0 47.0 1.0 1.0 COG5006 Threonine/homoserine_efflux_transporter_RhtA RhtA 47.0 0.0 1.0 0.0098999912644326 0.461385931000133 0.2356429611322827 0.4514859397357004 0 0 0 0 K11940 0.0 0.0769230769230769 hspQ; heat shock protein HspQ 92.0 29.0 28.0 2.0 0.966666666666667 S 0.0 30.0 1.0 1.0 COG3785 Heat_shock_protein_HspQ HspQ 30.0 0.0 1.0 0.0038419630354956 0.01067472434654 0.0072583436910178 0.0068327613110444 0 0 0 0 K11941 0.0342857142857142 0.0541310541310541 mdoC; glucans biosynthesis protein C [EC:2.1.-.-] 237.0 33.0 32.0 2.0 0.970588235294117 I 12.0 22.0 1.0 1.0 COG1835 Peptidoglycan/LPS_O-acetylase_OafA/YrhL,_contains_acyltransferase_and_SGNH-hydrolase_domains OafA 34.0 0.3529411764705882 0.6470588235294118 0.0073088364670987 0.0641815243781761 0.0357451804226374 0.0568726879110774 0 0 0 0 K11942 0.0257142857142857 0.168091168091168 icmF; isobutyryl-CoA mutase [EC:5.4.99.13] 963.0 57.0 47.0 4.0 0.826086956521739 EI 9.0 60.0 4.0 0.91304347826087 COG1703 GTPase_of_the_G3E_family_(not_a_periplasmic_protein_kinase) ArgK 69.0 0.1304347826086956 0.8695652173913043 0.0068126972060203 0.034709796040398 0.0207612466232091 0.0278970988343776 0 0 0 0 K11943 0.0 0.0028490028490028 nidA; PAH dioxygenase large subunit [EC:1.13.11.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 467.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 1.0 0.0 1.0 0 0 0 0 K11944 0.0 0.0085470085470085 nidB; PAH dioxygenase small subunit [EC:1.13.11.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 165.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 3.0 0.0 1.0 0 0 0 0 K11947 0.0 0.0056980056980056 nidD; aldehyde dehydrogenase [EC:1.2.1.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 461.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 2.0 0.0 1.0 0 0 0 0 K11950 0.0 0.0227920227920227 cmpA; bicarbonate transport system substrate-binding protein path:map02010 ABC transporters 425.0 9.0 0.0 1.0 1.0 P 0.0 9.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 9.0 0.0 1.0 0.0004893939179147 0.0133267590218973 0.006908076469906 0.0128373651039826 0 0 0 0 K11951 0.0 0.0256410256410256 cmpB; bicarbonate transport system permease protein path:map02010 ABC transporters 276.0 9.0 7.0 2.0 0.818181818181818 P 0.0 11.0 1.0 1.0 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 11.0 0.0 1.0 0.0003986982114127 0.0292479624668512 0.0148233303391319 0.0288492642554385 0 0 0 0 K11952 0.0 0.0227920227920227 cmpC; bicarbonate transport system ATP-binding protein [EC:7.3.2.-] path:map02010 ABC transporters 665.0 8.0 0.0 1.0 1.0 P 0.0 8.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 8.0 0.0 1.0 0.0005498290821586 0.0263634225165596 0.0134566257993591 0.025813593434401 0 0 0 0 K11953 0.0 0.0227920227920227 cmpD; bicarbonate transport system ATP-binding protein [EC:7.3.2.-] path:map02010 ABC transporters 263.0 14.0 0.0 1.0 1.0 P 0.0 14.0 1.0 1.0 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 14.0 0.0 1.0 0.0002966417478602 0.0072165120563542 0.0037565769021072 0.006919870308494 0 0 0 0 K11954 0.0171428571428571 0.0427350427350427 natB; neutral amino acid transport system substrate-binding protein path:map02010 ABC transporters 333.0 24.0 0.0 1.0 1.0 E 6.0 18.0 1.0 1.0 COG0683 ABC-type_branched-chain_amino_acid_transport_system,_periplasmic_component LivK 24.0 0.25 0.75 0.307745352798152 0.979412170594483 0.6435787616963176 0.671666817796331 0 0 0 0 K11955 0.0742857142857142 0.0313390313390313 natC; neutral amino acid transport system permease protein path:map02010 ABC transporters 249.0 42.0 38.0 3.0 0.893617021276596 E 36.0 11.0 1.0 1.0 COG4177 ABC-type_branched-chain_amino_acid_transport_system,_permease_component LivM 47.0 0.7659574468085106 0.2340425531914893 0.505960739423354 0.904400500145477 0.7051806197844155 0.398439760722123 0 1 0 1 K11956 0.0457142857142857 0.0911680911680911 natD; neutral amino acid transport system permease protein path:map02010 ABC transporters 254.0 41.0 31.0 3.0 0.759259259259259 E 19.0 35.0 1.0 1.0 COG0559 Branched-chain_amino_acid_ABC-type_transport_system,_permease_component LivH 54.0 0.3518518518518518 0.6481481481481481 0.418100139403941 0.997945964119374 0.7080230517616575 0.579845824715433 0 0 0 0 K11957 0.0114285714285714 0.0598290598290598 natA; neutral amino acid transport system ATP-binding protein path:map02010 ABC transporters 248.0 26.0 0.0 1.0 1.0 E 4.0 22.0 1.0 1.0 COG0411 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivG LivG 26.0 0.1538461538461538 0.8461538461538461 0.0605481754207271 0.369551296145964 0.2150497357833455 0.3090031207252369 0 0 0 0 K11958 0.0114285714285714 0.037037037037037 natE; neutral amino acid transport system ATP-binding protein path:map02010 ABC transporters 228.0 19.0 0.0 1.0 1.0 E 5.0 14.0 1.0 1.0 COG0410 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivF LivF 19.0 0.2631578947368421 0.7368421052631579 0.0089422258580571 0.0589543361764922 0.0339482810172746 0.050012110318435 0 0 0 0 K11959 0.0085714285714285 0.1566951566951566 urtA; urea transport system substrate-binding protein path:map02010 ABC transporters 337.0 66.0 61.0 2.0 0.929577464788732 E 3.0 68.0 4.0 0.915492957746479 COG0683 ABC-type_branched-chain_amino_acid_transport_system,_periplasmic_component LivK 71.0 0.0422535211267605 0.9577464788732394 0.0300620560364719 0.32792431334677 0.1789931846916209 0.2978622573102981 0 0 0 0 K11960 0.0085714285714285 0.1538461538461538 urtB; urea transport system permease protein path:map02010 ABC transporters 281.0 44.0 28.0 4.0 0.656716417910448 E 3.0 64.0 2.0 0.985074626865672 COG0559 Branched-chain_amino_acid_ABC-type_transport_system,_permease_component LivH 67.0 0.044776119402985 0.9552238805970148 0.0323632440361562 0.131155517946066 0.0817593809911111 0.0987922739099098 0 0 0 0 K11961 0.0085714285714285 0.1623931623931624 urtC; urea transport system permease protein path:map02010 ABC transporters 300.0 51.0 41.0 3.0 0.75 E 3.0 65.0 1.0 1.0 COG4177 ABC-type_branched-chain_amino_acid_transport_system,_permease_component LivM 68.0 0.0441176470588235 0.9558823529411764 0.0404256952907874 0.0337572284316582 0.0370914618612228 0.0066684668591291 0 0 0 0 K11962 0.0 0.1452991452991453 urtD; urea transport system ATP-binding protein path:map02010 ABC transporters 215.0 53.0 48.0 3.0 0.898305084745763 S 0.0 59.0 2.0 0.983050847457627 COG4674 ABC-type_uncharacterized_transport_system,_ATPase_component 59.0 0.0 1.0 0.0097037803798486 0.143505790710949 0.0766047855453987 0.1338020103311004 0 0 0 0 K11963 0.0114285714285714 0.1538461538461538 urtE; urea transport system ATP-binding protein path:map02010 ABC transporters 198.0 66.0 63.0 2.0 0.956521739130435 E 4.0 65.0 2.0 0.985507246376812 COG0410 ABC-type_branched-chain_amino_acid_transport_system,_ATPase_component_LivF LivF 69.0 0.0579710144927536 0.9420289855072465 0.0335716366730904 0.13072759967742 0.0821496181752552 0.0971559630043296 0 0 0 0 K11964 0.0 0.0028490028490028 PELI; pellino [EC:2.3.2.27] 274.0 0.0 1.0 1.0 1.0 2DKVT 1.0 0.0 1.0 0 0 0 0 K11987 0.0 0.0113960113960113 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1] path:map00590,path:map01100,path:map04064,path:map04370,path:map04625,path:map04657,path:map04668,path:map04723,path:map04726,path:map04913,path:map04921,path:map04923,path:map05010,path:map05022,path:map05140,path:map05163,path:map05165,path:map05167,path:map05200,path:map05204,path:map05206,path:map05222 Arachidonic acid metabolism,Metabolic pathways,NF-kappa B signaling pathway,VEGF signaling pathway,C-type lectin receptor signaling pathway,IL-17 signaling pathway,TNF signaling pathway,Retrograde endocannabinoid signaling,Serotonergic synapse,Ovarian steroidogenesis,Oxytocin signaling pathway,Regulation of lipolysis in adipocytes,Alzheimer disease,Pathways of neurodegeneration - multiple diseases,Leishmaniasis,Human cytomegalovirus infection,Human papillomavirus infection,Kaposi sarcoma-associated herpesvirus infection,Pathways in cancer,Chemical carcinogenesis - DNA adducts,MicroRNAs in cancer,Small cell lung cancer 482.0 2.0 0.0 2.0 0.5 C 0.0 4.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 4.0 0.0 1.0 0.0336892583673353 0.0587959783137538 0.0462426183405445 0.0251067199464185 0 0 0 0 K11990 0.0057142857142857 0.0 DHH; desert hedgehog path:map04340 Hedgehog signaling pathway 183.0 2.0 0.0 1.0 1.0 M 2.0 0.0 1.0 1.0 KOG3638 2.0 1.0 0.0 0 0 0 0 K11991 0.0114285714285714 0.8034188034188035 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] 65.0 268.0 241.0 6.0 0.8375 FJ 4.0 316.0 5.0 0.921875 COG0590 tRNA(Arg)_A34_adenosine_deaminase_TadA TadA 320.0 0.0125 0.9875 0.0302973348655429 0.109710687562067 0.0700040112138049 0.0794133526965241 0 0 0 0 K11994 0.0057142857142857 0.0 DNASE1; deoxyribonuclease-1 [EC:3.1.21.1] 250.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 arCOG07796 2.0 1.0 0.0 0 0 0 0 K11995 0.0057142857142857 0.0 DNASE1L; deoxyribonuclease-1-like protein [EC:3.1.21.-] 250.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 arCOG07796 2.0 1.0 0.0 0 0 0 0 K11996 0.0171428571428571 0.0 MOCS3, UBA4; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11] path:map04122 Sulfur relay system 367.0 6.0 0.0 1.0 1.0 H 6.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 6.0 1.0 0.0 1.46617318470091e-05 9.15701480156372e-05 5.311593993132315e-05 7.69084161686281e-05 0 0 0 0 K12048 0.0 0.0028490028490028 comB10; ComB10 competence protein 367.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG2948 Type_IV_secretory_pathway,_VirB10_component VirB10 1.0 0.0 1.0 0 0 0 0 K12049 0.0 0.0113960113960113 comB9; ComB9 competence protein 321.0 5.0 0.0 1.0 1.0 U 0.0 5.0 1.0 1.0 COG3504 Type_IV_secretory_pathway,_VirB9_components VirB9 5.0 0.0 1.0 0.044883796203243 0.0464315119438417 0.0456576540735423 0.0015477157405986 0 0 0 0 K12050 0.0 0.0028490028490028 comB8; ComB8 competence protein 197.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG3736 Type_IV_secretory_pathway,_component_VirB8 VirB8 1.0 0.0 1.0 0 0 0 0 K12052 0.0 0.0085470085470085 comB6; ComB6 competence protein 234.0 3.0 0.0 1.0 1.0 U 0.0 3.0 2.0 0.666666666666667 COG3846 Type_IV_secretory_pathway,_TrbL_components TrbL 3.0 0.0 1.0 0 0 0 0 K12053 0.0 0.0028490028490028 comB4; ComB4 competence protein 762.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 1.0 0.0 1.0 0 0 0 0 K12055 0.0028571428571428 0.0256410256410256 K12055, parA; chromosome partitioning related protein ParA 263.0 9.0 8.0 2.0 0.9 D 1.0 9.0 2.0 0.9 COG1192 ParA-like_ATPase_involved_in_chromosome/plasmid_partitioning_or_cellulose_biosynthesis_protein_BcsQ ParA 10.0 0.1 0.9 0.0876859918451665 0.157555095683547 0.1226205437643567 0.0698691038383805 0 0 0 0 K12056 0.0 0.037037037037037 traG; conjugal transfer mating pair stabilization protein TraG 479.0 10.0 3.0 3.0 0.555555555555556 G 0.0 19.0 4.0 0.578947368421053 COG4678 Muramidase_(phage_lambda_lysozyme) 19.0 0.0 1.0 0.0078968616081979 0.0200856781953529 0.0139912699017754 0.012188816587155 0 0 0 0 K12057 0.0028571428571428 0.0712250712250712 traF; conjugal transfer pilus assembly protein TraF 59.0 31.0 30.0 2.0 0.96875 CO 1.0 31.0 1.0 1.0 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 32.0 0.03125 0.96875 0.69901003528169 0.28763645691008 0.493323246095885 0.41137357837161 0 0 0 1 K12058 0.0 0.037037037037037 traN; conjugal transfer mating pair stabilization protein TraN 175.0 19.0 0.0 1.0 1.0 S 0.0 19.0 1.0 1.0 28KC1 19.0 0.0 1.0 0.0027507678920699 0.0110639397583168 0.0069073538251933 0.0083131718662469 0 0 0 0 K12059 0.0 0.017094017094017 trbC; conjugal transfer pilus assembly protein TrbC 121.0 10.0 0.0 1.0 1.0 S 0.0 10.0 3.0 0.5 29PHP 10.0 0.0 1.0 0.0022052047188416 0.0049240499595574 0.0035646273391995 0.0027188452407158 0 0 0 0 K12060 0.0 0.0398860398860398 traU; conjugal transfer pilus assembly protein TraU 282.0 18.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 28HGF 18.0 0.0 1.0 0.0035976615730352 0.0097911348081264 0.0066943981905808 0.0061934732350912 0 0 0 0 K12061 0.0 0.0398860398860398 traW; conjugal transfer pilus assembly protein TraW 169.0 15.0 0.0 1.0 1.0 S 0.0 18.0 3.0 0.5 2CGUX 18.0 0.0 1.0 0.0037038223138517 0.0095569471596307 0.0066303847367412 0.005853124845779 0 0 0 0 K12062 0.0 0.0398860398860398 trbI; conjugal transfer pilin signal peptidase TrbI 54.0 8.0 3.0 3.0 0.470588235294118 U 0.0 17.0 4.0 0.470588235294118 COG0681 Signal_peptidase_I LepB 17.0 0.0 1.0 0.020218404481542 0.0339332497016311 0.0270758270915865 0.0137148452200891 0 0 0 0 K12063 0.0 0.0712250712250712 traC; conjugal transfer ATP-binding protein TraC 135.0 24.0 18.0 4.0 0.705882352941176 U 0.0 34.0 4.0 0.705882352941177 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 34.0 0.0 1.0 0.0307709061050873 0.0405532089714473 0.0356620575382673 0.0097823028663599 0 0 0 0 K12064 0.0 0.0341880341880341 traV; conjugal transfer pilus assembly protein TraV 94.0 12.0 0.0 1.0 1.0 S 0.0 15.0 3.0 0.533333333333333 28M4U 15.0 0.0 1.0 0.0060374292575857 0.0141017821045483 0.010069605681067 0.0080643528469626 0 0 0 0 K12065 0.0 0.1339031339031339 traB; conjugal transfer pilus assembly protein TraB 21.0 28.0 16.0 3.0 0.538461538461538 D 0.0 57.0 7.0 0.389830508474576 COG2919 Cell_division_protein_FtsB FtsB 57.0 0.0 1.0 0.203482377127983 0.136390694478463 0.169936535803223 0.06709168264952 0 0 0 0 K12066 0.0 0.0427350427350427 traK; conjugal transfer pilus assembly protein TraK 160.0 14.0 9.0 3.0 0.7 S 0.0 20.0 6.0 0.25 2BDGE 20.0 0.0 1.0 0.0050395882332018 0.0099762806831691 0.0075079344581854 0.0049366924499673 0 0 0 0 K12067 0.0 0.0427350427350427 traE; conjugal transfer pilus assembly protein TraE 154.0 21.0 0.0 1.0 1.0 S 0.0 21.0 5.0 0.285714285714286 2DBUJ 21.0 0.0 1.0 0.0057974890390537 0.0266401744516782 0.0162188317453659 0.0208426854126245 0 0 0 0 K12068 0.0 0.0256410256410256 traL; conjugal transfer pilus assembly protein TraL 91.0 14.0 0.0 1.0 1.0 S 0.0 14.0 6.0 0.285714285714286 2B95I 14.0 0.0 1.0 0.0034752206006122 0.0107712716186158 0.007123246109614 0.0072960510180036 0 0 0 0 K12069 0.0 0.0113960113960113 traA; conjugal transfer pilus assembly protein TraA 94.0 0.0 4.0 2.0 0.75 28PQH 4.0 0.0 1.0 0 0 0 0 K12070 0.0 0.0227920227920227 traI; conjugal transfer pilus assembly protein TraI 110.0 5.0 3.0 3.0 0.625 S 0.0 8.0 2.0 0.875 COG3481 3'-5'_exoribonuclease_YhaM,_can_participate_in_23S_rRNA_maturation,__HD_superfamily YhaM 8.0 0.0 1.0 0.0360577536517766 0.079065644132084 0.0575616988919303 0.0430078904803074 0 0 0 0 K12071 0.0 0.0284900284900284 traD; conjugal transfer pilus assembly protein TraD 406.0 8.0 6.0 2.0 0.8 S 0.0 10.0 2.0 0.8 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 10.0 0.0 1.0 0.0317892964621603 0.0480061136406408 0.0398977050514005 0.0162168171784805 0 0 0 0 K12072 0.0028571428571428 0.0398860398860398 traH; conjugative transfer pilus assembly protein TraH 357.0 20.0 0.0 1.0 1.0 S 1.0 19.0 2.0 0.95 28MTB 20.0 0.05 0.95 0.0054426232965383 0.0231949867617605 0.0143188050291493 0.0177523634652222 0 0 0 0 K12073 0.02 0.0598290598290598 E3.1.2.28; 1,4-dihydroxy-2-naphthoyl-CoA hydrolase [EC:3.1.2.28] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 112.0 22.0 17.0 3.0 0.758620689655172 S 7.0 22.0 1.0 1.0 COG0824 Acyl-CoA_thioesterase_FadM FadM 29.0 0.2413793103448276 0.7586206896551724 0.0170475841991709 0.0355966437322766 0.0263221139657237 0.0185490595331056 0 0 0 0 K12080 0.0 0.0028490028490028 ptlC; type IV secretion system protein PtlC [EC:7.4.2.8] 816.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 1.0 0.0 1.0 0 0 0 0 K12085 0.0 0.0028490028490028 ptlF; type IV secretion system protein PtlF 257.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG3504 Type_IV_secretory_pathway,_VirB9_components VirB9 1.0 0.0 1.0 0 0 0 0 K12089 0.0 0.0028490028490028 cag4; cag pathogenicity island protein 4 path:map05120 Epithelial cell signaling in Helicobacter pylori infection 208.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 1.0 0.0 1.0 0 0 0 0 K12092 0.0 0.0056980056980056 cag7; cag pathogenicity island protein 7 path:map05120 Epithelial cell signaling in Helicobacter pylori infection 368.0 2.0 0.0 1.0 1.0 A 0.0 2.0 1.0 1.0 COG5183 2.0 0.0 1.0 0 0 0 0 K12095 0.0 0.0028490028490028 cag10; cag pathogenicity island protein 10 path:map05120 Epithelial cell signaling in Helicobacter pylori infection 216.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 COG3736 Type_IV_secretory_pathway,_component_VirB8 VirB8 1.0 0.0 1.0 0 0 0 0 K12096 0.0 0.0028490028490028 cag11; cag pathogenicity island protein 11 path:map05120 Epithelial cell signaling in Helicobacter pylori infection 63.0 0.0 3.0 1.0 1.0 2E5CH 3.0 0.0 1.0 0 0 0 0 K12111 0.0 0.0341880341880341 ebgA; evolved beta-galactosidase subunit alpha [EC:3.2.1.23] path:map00052,path:map00511,path:map01100 Galactose metabolism,Other glycan degradation,Metabolic pathways 938.0 13.0 0.0 1.0 1.0 G 0.0 13.0 1.0 1.0 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 13.0 0.0 1.0 0.0245128989404358 0.118705366450357 0.0716091326953964 0.0941924675099211 0 0 0 0 K12112 0.0 0.0113960113960113 ebgC; evolved beta-galactosidase subunit beta path:map00052,path:map00511,path:map01100 Galactose metabolism,Other glycan degradation,Metabolic pathways 148.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG2731 Beta-galactosidase,_beta_subunit EbgC 4.0 0.0 1.0 0.0220733453252602 0.0453512107183684 0.0337122780218143 0.0232778653931082 0 0 0 0 K12113 0.0 0.0085470085470085 ebgR; LacI family transcriptional regulator, ebg operon repressor 325.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 3.0 0.0 1.0 0 0 0 0 K12132 0.0 0.0 prkC, stkP; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1] 1065.0 897.0 24.0 0.695169712793734 KLT 0.0 0.0 66.0 0.677103718199609 COG0515 Serine/threonine_protein_kinase SPS1 0.0 0 0 0 0 K12136 0.0085714285714285 0.0199430199430199 hyfA; hydrogenase-4 component A [EC:1.-.-.-] 137.0 12.0 0.0 1.0 1.0 C 4.0 8.0 1.0 1.0 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 12.0 0.3333333333333333 0.6666666666666666 0.248636970638048 0.691175067957625 0.4699060192978365 0.4425380973195769 0 0 0 0 K12137 0.2542857142857143 0.1481481481481481 hyfB; hydrogenase-4 component B [EC:1.-.-.-] 311.0 103.0 24.0 2.0 0.565934065934066 C 114.0 68.0 2.0 0.769230769230769 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 182.0 0.6263736263736264 0.3736263736263736 0.736037640267576 0.986889659590846 0.861463649929211 0.2508520193232699 0 1 0 1 K12138 0.02 0.0341880341880341 hyfC; hydrogenase-4 component C [EC:1.-.-.-] 281.0 20.0 0.0 1.0 1.0 C 7.0 13.0 1.0 1.0 COG0650 Formate_hydrogenlyase_subunit_HyfC HyfC 20.0 0.35 0.65 0.0223923084961423 0.046450389314536 0.0344213489053391 0.0240580808183937 0 0 0 0 K12139 0.0114285714285714 0.0227920227920227 hyfD; hydrogenase-4 component D [EC:1.-.-.-] 412.0 8.0 0.0 2.0 0.5 C 4.0 12.0 2.0 0.875 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 16.0 0.25 0.75 0.0417434363228342 0.0659095845977283 0.0538265104602812 0.0241661482748941 0 0 0 0 K12140 0.1 0.1367521367521367 hyfE; hydrogenase-4 component E [EC:1.-.-.-] 152.0 87.0 0.0 1.0 1.0 C 35.0 52.0 1.0 1.0 COG4237 Hydrogenase-4_membrane_subunit_HyfE HyfE 87.0 0.4022988505747126 0.5977011494252874 0.147605529007428 0.33623950161094 0.241922515309184 0.188633972603512 0 0 0 0 K12141 0.1657142857142857 0.1709401709401709 hyfF; hydrogenase-4 component F [EC:1.-.-.-] 298.0 68.0 0.0 2.0 0.5 CP 67.0 69.0 1.0 1.0 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 136.0 0.4926470588235294 0.5073529411764706 0.637657962145441 0.943934683407964 0.7907963227767025 0.306276721262523 0 1 0 1 K12142 0.0028571428571428 0.0199430199430199 hyfG; hydrogenase-4 component G [EC:1.-.-.-] 151.0 10.0 0.0 1.0 1.0 C 2.0 8.0 2.0 0.5 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 10.0 0.2 0.8 0.036064926859849 0.0652931087567068 0.0506790178082778 0.0292281818968577 0 0 0 0 K12143 0.0771428571428571 0.0968660968660968 hyfH; hydrogenase-4 component H 98.0 65.0 0.0 1.0 1.0 C 28.0 36.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 64.0 0.4375 0.5625 0.629700168735156 0.812419022761953 0.7210595957485545 0.182718854026797 0 1 0 1 K12144 0.0171428571428571 0.0056980056980056 hyfI; hydrogenase-4 component I [EC:1.-.-.-] 138.0 9.0 0.0 1.0 1.0 C 6.0 3.0 1.0 1.0 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 9.0 0.6666666666666666 0.3333333333333333 0.0187711747023781 0.0641737046929947 0.0414724396976864 0.0454025299906166 0 0 0 0 K12145 0.0 0.0085470085470085 hyfJ; hydrogenase-4 component J [EC:1.-.-.-] 112.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 2DBX5 3.0 0.0 1.0 0 0 0 0 K12146 0.0028571428571428 0.0313390313390313 hyfR; hydrogenase-4 transcriptional activator 407.0 14.0 0.0 1.0 1.0 KT 1.0 13.0 2.0 0.857142857142857 COG3604 FhlA-type_transcriptional_regulator,_contains_GAF,_AAA-type_ATPase,_and_DNA-binding_Fis_domains FhlA 14.0 0.0714285714285714 0.9285714285714286 0.0158404589531056 0.0810614725940573 0.0484509657735814 0.0652210136409517 0 0 0 0 K12147 0.0 0.0056980056980056 msyB; acidic protein MsyB 124.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 291QA 2.0 0.0 1.0 0 0 0 0 K12148 0.0 0.0085470085470085 bssS; biofilm regulator BssS 83.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2CFXH 3.0 0.0 1.0 0 0 0 0 K12149 0.0 0.0085470085470085 dinI; DNA-damage-inducible protein I 79.0 2.0 1.0 2.0 0.666666666666667 L 0.0 3.0 2.0 0.666666666666667 2DMSQ 3.0 0.0 1.0 0 0 0 0 K12151 0.0 0.0028490028490028 bhsA; multiple stress resistance protein BhsA 85.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 2E4GN 2.0 0.0 1.0 0 0 0 0 K12152 0.0057142857142857 0.0427350427350427 nudJ; phosphatase NudJ [EC:3.6.1.-] path:map00740 Riboflavin metabolism 104.0 17.0 0.0 1.0 1.0 F 2.0 15.0 1.0 1.0 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 17.0 0.1176470588235294 0.8823529411764706 0.0634020522343196 0.103324685432443 0.0833633688333813 0.0399226331981233 0 0 0 0 K12158 0.0028571428571428 0.0 NEDD8; ubiquitin-like protein Nedd8 78.0 1.0 0.0 1.0 1.0 DO 1.0 0.0 1.0 1.0 COG5272 Ubiquitin UBI4 1.0 1.0 0.0 0 0 0 0 K12161 0.0142857142857142 0.0 URM1; ubiquitin related modifier 1 path:map04122 Sulfur relay system 89.0 5.0 0.0 1.0 1.0 O 5.0 0.0 1.0 1.0 COG5131 Ubiquitin-like_protein URM1 5.0 1.0 0.0 0.042934800808384 0.985682263913935 0.5143085323611595 0.942747463105551 0 0 0 0 K12164 0.0028571428571428 0.0 UBA5, UBE1DC1; ubiquitin-like modifier-activating enzyme 5 275.0 1.0 0.0 1.0 1.0 H 1.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 1.0 1.0 0.0 0 0 0 0 K12188 0.0314285714285714 0.0 SNF8, EAP30; ESCRT-II complex subunit VPS22 path:map04144 Endocytosis 214.0 8.0 4.0 2.0 0.666666666666667 U 12.0 0.0 1.0 1.0 KOG3341 12.0 1.0 0.0 0.134752803845605 0.555891323379062 0.3453220636123335 0.421138519533457 0 0 0 0 K12189 0.0257142857142857 0.0 VPS25, EAP20; ESCRT-II complex subunit VPS25 path:map04144 Endocytosis 217.0 6.0 4.0 3.0 0.666666666666667 H 9.0 0.0 1.0 1.0 KOG4068 9.0 1.0 0.0 0.248877551333684 0.802089005519079 0.5254832784263815 0.553211454185395 0 0 0 0 K12191 0.0085714285714285 0.0 CHMP2A; charged multivesicular body protein 2A path:map04144,path:map04217 Endocytosis,Necroptosis 187.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 COG5491 Archaeal_cell_division_protein_CdvB,_Snf7/Vps24/ESCRT-III_family Did4 3.0 1.0 0.0 0 0 0 0 K12194 0.0085714285714285 0.0 CHMP4A_B, SNF7, VPS32A_B; charged multivesicular body protein 4A/B path:map03250,path:map04144,path:map04217 Viral life cycle - HIV-1,Endocytosis,Necroptosis 205.0 3.0 0.0 1.0 1.0 U 3.0 0.0 1.0 1.0 KOG1656 3.0 1.0 0.0 0 0 0 0 K12196 0.0485714285714285 0.0 VPS4; vacuolar protein-sorting-associated protein 4 path:map03250,path:map04144,path:map04217 Viral life cycle - HIV-1,Endocytosis,Necroptosis 361.0 17.0 0.0 1.0 1.0 O 17.0 0.0 1.0 1.0 KOG0739 17.0 1.0 0.0 0.0020284854865332 0.263542202996242 0.1327853442413876 0.2615137175097087 0 0 0 0 K12197 0.0142857142857142 0.0 CHMP1, VPS46, DID2; charged multivesicular body protein 1 path:map04144,path:map04217 Endocytosis,Necroptosis 201.0 5.0 0.0 1.0 1.0 U 5.0 0.0 1.0 1.0 COG5491 Archaeal_cell_division_protein_CdvB,_Snf7/Vps24/ESCRT-III_family Did4 5.0 1.0 0.0 0.663217814448083 0.921046630092387 0.7921322222702349 0.2578288156443039 0 0 0 1 K12202 0.0 0.0056980056980056 dotA; defect in organelle trafficking protein DotA 701.0 2.0 0.0 1.0 1.0 EG 0.0 2.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 2.0 0.0 1.0 0 0 0 0 K12203 0.0 0.017094017094017 dotB, traJ; defect in organelle trafficking protein DotB [EC:7.2.4.8] 337.0 6.0 0.0 1.0 1.0 NU 0.0 6.0 1.0 1.0 COG2805 Type_IV_pilus_assembly_protein_PilT,_pilus_retraction_ATPase PilT 6.0 0.0 1.0 9.46634470246559e-12 1.426875414909e-11 1.1867549425777795e-11 4.80240944662441e-12 0 0 0 0 K12204 0.0 0.0626780626780626 dotC, traI; defect in organelle trafficking protein DotC 59.0 28.0 0.0 1.0 1.0 M 0.0 27.0 3.0 0.535714285714286 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 27.0 0.0 1.0 0.0916839904571137 0.0826867738389327 0.0871853821480232 0.0089972166181809 0 0 0 0 K12205 0.0 0.0056980056980056 dotD, traH; defect in organelle trafficking protein DotD 143.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EP3K 2.0 0.0 1.0 0 0 0 0 K12206 0.0 0.0056980056980056 icmB, dotO; intracellular multiplication protein IcmB [EC:7.2.4.8] 974.0 2.0 0.0 1.0 1.0 U 0.0 2.0 1.0 1.0 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 2.0 0.0 1.0 0 0 0 0 K12207 0.0 0.0028490028490028 icmC, dotE; intracellular multiplication protein IcmC 193.0 0.0 1.0 1.0 1.0 2EM6K 1.0 0.0 1.0 0 0 0 0 K12208 0.0 0.0028490028490028 icmD, dotP; intracellular multiplication protein IcmD 134.0 0.0 2.0 1.0 1.0 2FEZ2 2.0 0.0 1.0 0 0 0 0 K12209 0.0 0.0085470085470085 icmE, dotG; intracellular multiplication protein IcmE 98.0 2.0 0.0 2.0 0.5 U 0.0 4.0 2.0 0.75 COG1357 Uncharacterized_conserved_protein_YjbI,_contains_pentapeptide_repeats YjbI 4.0 0.0 1.0 0.106050915525661 0.259454785105124 0.1827528503153924 0.153403869579463 0 0 0 0 K12210 0.0 0.0056980056980056 icmF; intracellular multiplication protein IcmF 933.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3523 Type_VI_protein_secretion_system_component_VasK IcmF 2.0 0.0 1.0 0 0 0 0 K12211 0.0 0.0028490028490028 icmG, dotF; intracellular multiplication protein IcmG 280.0 0.0 1.0 1.0 1.0 2FCGP 1.0 0.0 1.0 0 0 0 0 K12212 0.0057142857142857 0.0028490028490028 icmJ, dotN; intracellular multiplication protein IcmJ 153.0 3.0 0.0 1.0 1.0 V 2.0 1.0 1.0 1.0 COG1403 5-methylcytosine-specific_restriction_endonuclease_McrA McrA 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K12213 0.0 0.0056980056980056 icmK, traN, dotH; intracellular multiplication protein IcmK 354.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2CPXU 2.0 0.0 1.0 0 0 0 0 K12214 0.0 0.0056980056980056 icmL, traM, dotI; intracellular multiplication protein IcmL 207.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2BVH1 2.0 0.0 1.0 0 0 0 0 K12215 0.0 0.0028490028490028 icmM, dotJ; intracellular multiplication protein IcmM 95.0 0.0 1.0 1.0 1.0 2AP9T 1.0 0.0 1.0 0 0 0 0 K12216 0.0 0.0341880341880341 icmN, lphA, dotK; intracellular multiplication protein IcmN 196.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 13.0 0.0 1.0 0.0444076992111268 0.100224247656691 0.0723159734339089 0.0558165484455642 0 0 0 0 K12217 0.0057142857142857 0.0142450142450142 icmO, trbC, dotL; intracellular multiplication protein IcmO [EC:7.2.4.8] 212.0 5.0 3.0 2.0 0.714285714285714 S 2.0 5.0 2.0 0.714285714285714 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 7.0 0.2857142857142857 0.7142857142857143 0.0732908081301667 0.176424121279098 0.1248574647046323 0.1031333131489313 0 0 0 0 K12218 0.0 0.0028490028490028 icmP, trbA; intracellular multiplication protein IcmP 376.0 0.0 1.0 1.0 1.0 2CA66 1.0 0.0 1.0 0 0 0 0 K12219 0.0 0.0028490028490028 icmQ; intracellular multiplication protein IcmQ 192.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2FEV6 1.0 0.0 1.0 0 0 0 0 K12221 0.0 0.0028490028490028 icmS; intracellular multiplication protein IcmS 114.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2F7G7 1.0 0.0 1.0 0 0 0 0 K12222 0.0 0.0056980056980056 icmT, traK; intracellular multiplication protein IcmT 76.0 0.0 2.0 1.0 1.0 2EJ1A 2.0 0.0 1.0 0 0 0 0 K12223 0.0 0.0028490028490028 icmV; intracellular multiplication protein IcmV 149.0 0.0 1.0 1.0 1.0 28WIK 1.0 0.0 1.0 0 0 0 0 K12224 0.0 0.0028490028490028 icmW; intracellular multiplication protein IcmW 151.0 0.0 1.0 1.0 1.0 2F57B 1.0 0.0 1.0 0 0 0 0 K12225 0.0 0.0028490028490028 icmX; intracellular multiplication protein IcmX 488.0 0.0 1.0 1.0 1.0 2A8CX 1.0 0.0 1.0 0 0 0 0 K12226 0.0 0.0028490028490028 tphA; proline/betaine transport protein TphA 418.0 1.0 0.0 1.0 1.0 EGP 0.0 1.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 1.0 0.0 1.0 0 0 0 0 K12228 0.0 0.0113960113960113 trbB; TrbB protein 108.0 3.0 2.0 2.0 0.75 O 0.0 4.0 1.0 1.0 COG1651 Protein_thiol-disulfide_isomerase_DsbC DsbG 4.0 0.0 1.0 0.156352278476804 0.399918733209662 0.278135505843233 0.2435664547328579 0 0 0 0 K12234 0.4228571428571429 0.131054131054131 cofE; coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 169.0 128.0 73.0 4.0 0.587155963302752 H 170.0 47.0 3.0 0.940366972477064 COG1478 F420-0:Gamma-glutamyl_ligase_(F420_biosynthesis) CofE 217.0 0.783410138248848 0.216589861751152 0.54365966861825 0.959414970990155 0.7515373198042026 0.415755302371905 0 1 0 1 K12235 0.0028571428571428 0.0 SRR; serine racemase [EC:5.1.1.18] path:map00260,path:map00470,path:map01100 Glycine, serine and threonine metabolism,D-Amino acid metabolism,Metabolic pathways 56.0 1.0 0.0 1.0 1.0 ET 1.0 0.0 1.0 1.0 COG1171 Threonine_deaminase IlvA 1.0 1.0 0.0 0 0 0 0 K12238 0.0 0.017094017094017 pchD; salicylate---[aryl-carrier protein] ligase [EC:6.2.1.61] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 487.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 1.0 1.0 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 6.0 0.0 1.0 0.0137948543261081 0.0482459308403733 0.0310203925832407 0.0344510765142652 0 0 0 0 K12239 0.0 0.0142450142450142 pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 1136.0 5.0 0.0 1.0 1.0 Q 0.0 5.0 2.0 0.8 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 5.0 0.0 1.0 0.0030091146650815 0.010959557452379 0.0069843360587302 0.0079504427872975 0 0 0 0 K12240 0.0028571428571428 0.0284900284900284 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] path:map01053 Biosynthesis of siderophore group nonribosomal peptides 115.0 16.0 0.0 1.0 1.0 Q 1.0 15.0 2.0 0.5625 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 16.0 0.0625 0.9375 7.27162442023651e-13 0.0079017137433287 0.0039508568720279 0.0079017137426015 0 0 0 0 K12241 0.0 0.0056980056980056 pchG; pyochelin biosynthesis protein PchG path:map01053 Biosynthesis of siderophore group nonribosomal peptides 325.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG4693 Oxidoreductase_(NAD-binding),_involved_in_siderophore_biosynthesis PchG 2.0 0.0 1.0 0 0 0 0 K12242 0.0 0.0085470085470085 pchC; pyochelin biosynthesis protein PchC 223.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG3208 Surfactin_synthase_thioesterase_subunit GrsT 3.0 0.0 1.0 0 0 0 0 K12243 0.0 0.0227920227920227 pchR; AraC family transcriptional regulator, transcriptional activator of the genes for pyochelin and ferripyochelin receptors 270.0 11.0 0.0 1.0 1.0 K 0.0 11.0 2.0 0.909090909090909 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 11.0 0.0 1.0 0.0079055240553461 0.016684544550218 0.012295034302782 0.0087790204948718 0 0 0 0 K12250 0.0 0.0028490028490028 ptlA; pentalenene synthase [EC:4.2.3.7] path:map00909,path:map00998,path:map01100,path:map01110 Sesquiterpenoid and triterpenoid biosynthesis,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 50.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K12251 0.0485714285714285 0.2934472934472934 aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 189.0 119.0 110.0 4.0 0.901515151515152 S 22.0 110.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 132.0 0.1666666666666666 0.8333333333333334 0.0449285908699996 0.924078659019142 0.4845036249445708 0.8791500681491424 0 0 0 0 K12252 0.0 0.0284900284900284 aruH; arginine:pyruvate transaminase [EC:2.6.1.84] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 374.0 11.0 10.0 2.0 0.916666666666667 E 0.0 12.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 12.0 0.0 1.0 0.0260499390990802 0.0925556378530089 0.0593027884760445 0.0665056987539287 0 0 0 0 K12253 0.0 0.0056980056980056 aruI; 5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 514.0 2.0 0.0 1.0 1.0 EH 0.0 2.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 2.0 0.0 1.0 0 0 0 0 K12254 0.0 0.0199430199430199 kauB; 4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 497.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 8.0 0.0 1.0 0.0419029208664597 0.0627983953912024 0.052350658128831 0.0208954745247426 0 0 0 0 K12255 0.02 0.0712250712250712 gbuA; guanidinobutyrase [EC:3.5.3.7] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 178.0 33.0 0.0 1.0 1.0 E 7.0 26.0 1.0 1.0 COG0010 Arginase/agmatinase_family_enzyme SpeB 33.0 0.2121212121212121 0.7878787878787878 0.0195594456818344 0.0805736756608102 0.0500665606713223 0.0610142299789757 0 0 0 0 K12256 0.0 0.0883190883190883 spuC; putrescine---pyruvate transaminase [EC:2.6.1.113] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 413.0 27.0 20.0 2.0 0.794117647058823 H 0.0 34.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 34.0 0.0 1.0 0.0089212628628974 0.0462784535825734 0.0275998582227354 0.037357190719676 0 0 0 0 K12257 0.0 0.5698005698005698 secDF; SecD/SecF fusion protein path:map02024,path:map03060,path:map03070 Quorum sensing,Protein export,Bacterial secretion system 231.0 255.0 253.0 4.0 0.984555984555985 U 0.0 239.0 5.0 0.494208494208494 COG0342 Preprotein_translocase_subunit_SecD SecD 239.0 0.0 1.0 0.547310894163385 0.97296056624411 0.7601357302037475 0.425649672080725 0 0 0 1 K12261 0.0 0.0028490028490028 HACL1; 2-hydroxyacyl-CoA lyase [EC:4.1.2.63] path:map04146 Peroxisome 550.0 1.0 0.0 1.0 1.0 EH 0.0 1.0 1.0 1.0 COG0028 Acetolactate_synthase_large_subunit_or_other_thiamine_pyrophosphate-requiring_enzyme IlvB 1.0 0.0 1.0 0 0 0 0 K12262 0.0114285714285714 0.1452991452991453 cybB; superoxide oxidase [EC:1.10.3.17] 94.0 86.0 76.0 3.0 0.88659793814433 C 5.0 92.0 4.0 0.876288659793814 COG3038 Cytochrome_b561 CybB 97.0 0.0515463917525773 0.9484536082474226 0.0015402140706461 0.0074893058536179 0.004514759962132 0.0059490917829718 0 0 0 0 K12263 0.0 0.0541310541310541 cccB; cytochrome c551 72.0 32.0 0.0 1.0 1.0 C 0.0 32.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 32.0 0.0 1.0 0.0053692162035351 0.010651054165055 0.008010135184295 0.0052818379615198 0 0 0 0 K12264 0.0 0.0227920227920227 norV; anaerobic nitric oxide reductase flavorubredoxin 70.0 8.0 0.0 1.0 1.0 C 0.0 8.0 2.0 0.875 COG0426 Flavorubredoxin NorV 8.0 0.0 1.0 0.0645231567568389 0.174819298807234 0.1196712277820364 0.1102961420503951 0 0 0 0 K12265 0.0 0.017094017094017 norW; nitric oxide reductase FlRd-NAD(+) reductase [EC:1.18.1.-] 377.0 6.0 0.0 1.0 1.0 C 0.0 6.0 2.0 0.5 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 6.0 0.0 1.0 0.0512666369133774 0.0751158799317342 0.0631912584225558 0.0238492430183568 0 0 0 0 K12266 0.0028571428571428 0.0598290598290598 norR; anaerobic nitric oxide reductase transcription regulator 279.0 15.0 6.0 3.0 0.535714285714286 KT 1.0 27.0 5.0 0.464285714285714 COG3604 FhlA-type_transcriptional_regulator,_contains_GAF,_AAA-type_ATPase,_and_DNA-binding_Fis_domains FhlA 28.0 0.0357142857142857 0.9642857142857144 0.0043212395404354 0.0164318832949439 0.0103765614176896 0.0121106437545085 0 0 0 0 K12267 0.1171428571428571 0.4074074074074074 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] 50.0 200.0 174.0 6.0 0.803212851405622 O 46.0 174.0 6.0 0.742971887550201 COG0225 Peptide_methionine_sulfoxide_reductase_MsrA MsrA 220.0 0.209090909090909 0.7909090909090909 0.415494488661276 0.315417069274906 0.365455778968091 0.1000774193863699 0 0 0 0 K12268 0.0 0.0028490028490028 asp1; accessory secretory protein Asp1 511.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2CI7G 1.0 0.0 1.0 0 0 0 0 K12269 0.0 0.0028490028490028 asp2; accessory secretory protein Asp2 508.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 1.0 0.0 1.0 0 0 0 0 K12270 0.0 0.0028490028490028 asp3; accessory secretory protein Asp3 333.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2AFSZ 1.0 0.0 1.0 0 0 0 0 K12276 0.0 0.0341880341880341 mshE; MSHA biogenesis protein MshE path:map05111 Biofilm formation - Vibrio cholerae 555.0 12.0 0.0 1.0 1.0 NU 0.0 12.0 1.0 1.0 COG2804 Type_II_secretory_pathway_ATPase_GspE/PulE_or_T4P_pilus_assembly_pathway_ATPase_PilB PulE 12.0 0.0 1.0 0.0291235373517912 0.0494223972830006 0.0392729673173959 0.0202988599312094 0 0 0 0 K12277 0.0 0.0028490028490028 mshF; MSHA biogenesis protein MshF 151.0 0.0 1.0 1.0 1.0 29NRZ 1.0 0.0 1.0 0 0 0 0 K12278 0.0 0.074074074074074 mshG; MSHA biogenesis protein MshG 352.0 18.0 4.0 2.0 0.5625 NU 0.0 32.0 1.0 1.0 COG1459 Type_II_secretory_pathway,_component_PulF PulF 32.0 0.0 1.0 0.582911946698742 0.306517570470263 0.4447147585845025 0.276394376228479 0 0 0 1 K12279 0.0 0.0313390313390313 mshI; MSHA biogenesis protein MshI 27.0 14.0 0.0 1.0 1.0 NU 0.0 14.0 2.0 0.642857142857143 COG4972 Type_IV_pilus_assembly_protein,_ATPase_PilM PilM 14.0 0.0 1.0 0.0467026253578441 0.0798868152890989 0.0632947203234715 0.0331841899312548 0 0 0 0 K12280 0.0 0.0512820512820512 mshJ; MSHA biogenesis protein MshJ 153.0 13.0 8.0 2.0 0.722222222222222 NU 0.0 18.0 2.0 0.722222222222222 COG3167 Type_IV_pilus_assembly_protein_PilO PilO 18.0 0.0 1.0 0.0422832228071011 0.161967141011994 0.1021251819095475 0.1196839182048929 0 0 0 0 K12281 0.0 0.0199430199430199 mshK; MSHA biogenesis protein MshK 98.0 1.0 0.0 1.0 1.0 S 0.0 7.0 2.0 0.857142857142857 2DR7A 7.0 0.0 1.0 0.0128288276563052 0.0347093813576779 0.0237691045069915 0.0218805537013727 0 0 0 0 K12282 0.0 0.0854700854700854 mshL; MSHA biogenesis protein MshL 238.0 20.0 8.0 2.0 0.625 NU 0.0 32.0 2.0 0.625 COG1450 Type_II_secretory_pathway_component_GspD/PulD_(secretin) PulD 32.0 0.0 1.0 0.160891545029368 0.33983750203782 0.250364523533594 0.1789459570084519 0 0 0 0 K12283 0.0 0.0256410256410256 mshM; MSHA biogenesis protein MshM 255.0 10.0 0.0 1.0 1.0 U 0.0 10.0 2.0 0.9 COG3267 Type_II_secretory_pathway_ATPase_component_GspA/ExeA/MshM ExeA 10.0 0.0 1.0 0.0496796076830136 0.0931961206922747 0.0714378641876441 0.0435165130092611 0 0 0 0 K12284 0.0 0.017094017094017 mshN; MSHA biogenesis protein MshN 335.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 6.0 0.0 1.0 0.0183934149229637 0.0438279216645044 0.031110668293734 0.0254345067415407 0 0 0 0 K12285 0.0 0.0769230769230769 mshO; MSHA biogenesis protein MshO 34.0 36.0 0.0 1.0 1.0 NU 0.0 36.0 4.0 0.666666666666667 COG2165 Type_II_secretory_pathway,_pseudopilin_PulG PulG 36.0 0.0 1.0 0.837850598193636 0.0963821247804677 0.4671163614870519 0.7414684734131683 0 0 1 1 K12286 0.0 0.0398860398860398 mshP; MSHA biogenesis protein MshP 103.0 9.0 6.0 2.0 0.75 NU 0.0 15.0 4.0 0.6 COG4726 Type_IV_pilus_assembly_protein_PilX PilX 15.0 0.0 1.0 0.0257031599381422 0.045735823265298 0.03571949160172 0.0200326633271558 0 0 0 0 K12287 0.0514285714285714 0.1481481481481481 mshQ; MSHA biogenesis protein MshQ 11.0 18.0 3.0 14.0 0.230769230769231 U 20.0 71.0 26.0 0.141304347826087 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 91.0 0.2197802197802197 0.7802197802197802 0.210226117920126 0.333538927076367 0.2718825224982465 0.123312809156241 0 0 0 0 K12288 0.0 0.0199430199430199 hofM; pilus assembly protein HofM 151.0 8.0 0.0 1.0 1.0 NU 0.0 8.0 1.0 1.0 COG4972 Type_IV_pilus_assembly_protein,_ATPase_PilM PilM 8.0 0.0 1.0 0.449364023976708 0.724427675365386 0.586895849671047 0.275063651388678 0 0 0 0 K12289 0.0 0.0484330484330484 hofN; pilus assembly protein HofN 80.0 18.0 0.0 1.0 1.0 NU 0.0 18.0 1.0 1.0 COG3166 Type_IV_pilus_assembly_protein_PilN PilN 18.0 0.0 1.0 0.946692671351572 0.123744014709053 0.5352183430303125 0.822948656642519 0 0 1 1 K12290 0.0 0.0056980056980056 hofO; pilus assembly protein HofO 141.0 1.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 2CD7R 2.0 0.0 1.0 0 0 0 0 K12291 0.0 0.0056980056980056 hofP; pilus assembly protein HofP 98.0 2.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 2EBIY 2.0 0.0 1.0 0 0 0 0 K12296 0.0 0.0569800569800569 comX1_2; competence protein ComX path:map02020,path:map02024 Two-component system,Quorum sensing 192.0 21.0 0.0 1.0 1.0 K 0.0 21.0 1.0 1.0 COG1595 DNA-directed_RNA_polymerase_specialized_sigma_subunit,_sigma24_family RpoE 21.0 0.0 1.0 0.022070616467757 0.0015329103891743 0.0118017634284656 0.0205377060785827 0 0 0 0 K12297 0.0057142857142857 0.1538461538461538 rlmKL; 23S rRNA (guanine2069-N7)-methyltransferase / 23S rRNA (guanine2445-N2)-methyltransferase [EC:2.1.1.264 2.1.1.173] 214.0 39.0 12.0 3.0 0.565217391304348 J 2.0 59.0 2.0 0.797101449275362 COG0116 23S_rRNA_G2445_N2-methylase_RlmL RlmL 61.0 0.0327868852459016 0.9672131147540984 0.0340529843989592 0.0323353859748451 0.0331941851869021 0.001717598424114 0 0 0 0 K12299 0.0 0.0028490028490028 garP; MFS transporter, ACS family, probable galactarate transporter 429.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG2271 Sugar_phosphate_permease UhpC 3.0 0.0 1.0 0 0 0 0 K12308 0.0457142857142857 0.2136752136752136 bgaB, lacA; beta-galactosidase [EC:3.2.1.23] path:map00052 Galactose metabolism 32.0 165.0 163.0 4.0 0.976331360946745 G 17.0 148.0 5.0 0.976331360946746 COG1874 Beta-galactosidase_GanA GanA 165.0 0.103030303030303 0.896969696969697 0.230039771693112 0.48647740108715 0.358258586390131 0.256437629394038 0 0 0 0 K12339 0.1085714285714285 0.2905982905982906 cysM; S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) [EC:2.5.1.144] path:map00270,path:map01100,path:map01230 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids 232.0 130.0 114.0 3.0 0.860927152317881 E 40.0 111.0 1.0 1.0 COG0031 Cysteine_synthase CysK 151.0 0.2649006622516556 0.7350993377483444 0.169094368717375 0.832225259978801 0.500659814348088 0.663130891261426 0 0 0 0 K12340 0.0028571428571428 0.4074074074074074 tolC, bepC, cyaE, raxC, sapF, rsaF, hasF; outer membrane protein path:map01501,path:map01503,path:map02020,path:map03070,path:map04626,path:map05133 beta-Lactam resistance,Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Bacterial secretion system,Plant-pathogen interaction,Pertussis 61.0 209.0 206.0 2.0 0.985849056603774 MU 1.0 209.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 210.0 0.0047619047619047 0.9952380952380953 0.0350044419721299 0.226853405109339 0.1309289235407344 0.1918489631372091 0 0 0 0 K12341 0.0 0.0056980056980056 yadA; adhesin YadA path:map03070,path:map05135 Bacterial secretion system,Yersinia infection 381.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1293 Ribosome_quality_control_(RQC)_protein_RqcH,_Rqc2/NEMF/Tae2_family,_contains_fibronectin-(FbpA)_and_RNA-_(NFACT)_binding_domains RqcH 2.0 0.0 1.0 0 0 0 0 K12342 0.0028571428571428 0.0028490028490028 yadB_C; adhesin YadB/C path:map03070 Bacterial secretion system 163.0 2.0 0.0 1.0 1.0 UW 1.0 1.0 1.0 1.0 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 2.0 0.5 0.5 0 0 0 0 K12343 0.0057142857142857 0.0085470085470085 SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22] path:map00140,path:map01100 Steroid hormone biosynthesis,Metabolic pathways 252.0 5.0 0.0 1.0 1.0 S 2.0 3.0 2.0 0.8 2DBF0 5.0 0.4 0.6 0.0284861201399718 0.0763559652396695 0.0524210426898206 0.0478698450996977 0 0 0 0 K12349 0.0 0.037037037037037 ASAH2; neutral ceramidase [EC:3.5.1.23] path:map00600,path:map01100,path:map04071 Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway 452.0 11.0 7.0 2.0 0.733333333333333 G 0.0 15.0 3.0 0.733333333333333 COG2133 Glucose/arabinose_dehydrogenase,_beta-propeller_fold YliI 15.0 0.0 1.0 0.0263211463007369 0.0499236319576649 0.0381223891292009 0.023602485656928 0 0 0 0 K12351 0.0 0.0056980056980056 SMPD2; sphingomyelin phosphodiesterase 2 [EC:3.1.4.12] path:map00600,path:map01100,path:map04071 Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway 252.0 2.0 0.0 1.0 1.0 N 0.0 2.0 1.0 1.0 COG3568 Metal-dependent_hydrolase,_endonuclease/exonuclease/phosphatase_family ElsH 2.0 0.0 1.0 0 0 0 0 K12368 0.0 0.0626780626780626 dppA; dipeptide transport system substrate-binding protein path:map02010,path:map02030 ABC transporters,Bacterial chemotaxis 517.0 30.0 0.0 1.0 1.0 E 0.0 30.0 2.0 0.966666666666667 COG0747 ABC-type_transport_system,_periplasmic_component DdpA 30.0 0.0 1.0 0.0148251304322649 0.0550618276635095 0.0349434790478872 0.0402366972312445 0 0 0 0 K12369 0.02 0.074074074074074 dppB; dipeptide transport system permease protein path:map02010 ABC transporters 309.0 37.0 28.0 3.0 0.770833333333333 P 19.0 29.0 1.0 1.0 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 48.0 0.3958333333333333 0.6041666666666666 0.887738942523846 0.0883721076383368 0.4880555250810914 0.7993668348855092 1 1 1 1 K12370 0.0028571428571428 0.074074074074074 dppC; dipeptide transport system permease protein path:map02010 ABC transporters 284.0 21.0 16.0 4.0 0.724137931034483 EP 1.0 28.0 2.0 0.931034482758621 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 29.0 0.0344827586206896 0.9655172413793104 0.0160263132536121 0.0437206059943339 0.029873459623973 0.0276942927407218 0 0 0 0 K12371 0.0 0.0626780626780626 dppD; dipeptide transport system ATP-binding protein path:map02010 ABC transporters 304.0 19.0 8.0 2.0 0.633333333333333 P 0.0 30.0 2.0 0.966666666666667 COG0444 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppD 30.0 0.0 1.0 0.0077230633066868 0.0166327712721694 0.0121779172894281 0.0089097079654826 0 0 0 0 K12372 0.0085714285714285 0.0712250712250712 dppF; dipeptide transport system ATP-binding protein path:map02010 ABC transporters 285.0 24.0 15.0 2.0 0.727272727272727 P 4.0 29.0 1.0 1.0 COG4608 ABC-type_oligopeptide_transport_system,_ATPase_component AppF 33.0 0.1212121212121212 0.8787878787878788 0.0247479369125354 0.0416329474691124 0.0331904421908239 0.016885010556577 0 0 0 0 K12373 0.0114285714285714 0.2165242165242165 HEXA_B; hexosaminidase [EC:3.2.1.52] path:map00511,path:map00513,path:map00520,path:map00531,path:map00600,path:map00603,path:map00604,path:map01100,path:map04142 Other glycan degradation,Various types of N-glycan biosynthesis,Amino sugar and nucleotide sugar metabolism,Glycosaminoglycan degradation,Sphingolipid metabolism,Glycosphingolipid biosynthesis - globo and isoglobo series,Glycosphingolipid biosynthesis - ganglio series,Metabolic pathways,Lysosome 122.0 153.0 142.0 6.0 0.905325443786982 G 6.0 163.0 12.0 0.834319526627219 COG3525 N-acetyl-beta-hexosaminidase Chb 169.0 0.0355029585798816 0.9644970414201184 0.210561662689257 0.200491397072206 0.2055265298807315 0.0100702656170509 0 0 0 0 K12376 0.0 0.0028490028490028 ARSK; arylsulfatase K [EC:3.1.6.-] 496.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG3119 Arylsulfatase_A_or_related_enzyme,_AlkP_superfamily AslA 1.0 0.0 1.0 0 0 0 0 K12384 0.0057142857142857 0.0 SCARB2, LIMP2, CD36L2; lysosome membrane protein 2 path:map04142 Lysosome 194.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG3776 2.0 1.0 0.0 0 0 0 0 K12409 0.0 0.0028490028490028 GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 313.0 1.0 0.0 1.0 1.0 GK 0.0 1.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 1.0 0.0 1.0 0 0 0 0 K12410 0.3171428571428571 0.5698005698005698 npdA; NAD-dependent deacetylase [EC:2.3.1.286] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 78.0 376.0 356.0 3.0 0.947103274559194 K 159.0 238.0 1.0 1.0 COG0846 NAD-dependent_protein_deacetylase,_SIR2_family SIR2 397.0 0.4005037783375315 0.5994962216624685 0.142344895977461 0.45515285976083 0.2987488778691455 0.3128079637833689 0 0 0 0 K12419 0.0028571428571428 0.0 FADS6; fatty acid desaturase 6 [EC:1.14.19.-] 321.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2CMDI 1.0 1.0 0.0 0 0 0 0 K12420 0.0 0.0142450142450142 actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-] path:map00253,path:map01056,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 254.0 5.0 0.0 1.0 1.0 IQ 0.0 5.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 5.0 0.0 1.0 2.92046532329095e-05 0.000416835642721 0.0002230201479769 0.000387630989488 0 0 0 0 K12421 0.0 0.0142450142450142 fadD9; fatty acid CoA ligase FadD9 62.0 6.0 5.0 2.0 0.857142857142857 IQ 0.0 7.0 2.0 0.571428571428571 COG1022 Long-chain_acyl-CoA_synthetase_(AMP-forming) FAA1 7.0 0.0 1.0 0.0054323277965485 0.0241070658093466 0.0147696968029475 0.0186747380127981 0 0 0 0 K12423 0.0 0.0085470085470085 fadD21; fatty acid CoA ligase FadD21 544.0 4.0 0.0 1.0 1.0 IQ 0.0 4.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 4.0 0.0 1.0 0.0028797757557674 0.0185951633887016 0.0107374695722345 0.0157153876329342 0 0 0 0 K12424 0.0 0.0113960113960113 fadD22; 4-hydroxybenzoate adenylyltransferase [EC:6.2.1.50] 416.0 3.0 1.0 2.0 0.6 I 0.0 5.0 3.0 0.6 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 5.0 0.0 1.0 0.0041595510986962 5.628999273618461e-09 0.0020797783638477 0.0041595454696969 0 0 0 0 K12425 0.0 0.0056980056980056 fadD23; long-chain fatty acid adenylase/transferase FadD23 [EC:6.2.1.57] 567.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 2.0 0.0 1.0 0 0 0 0 K12426 0.0 0.0085470085470085 fadD26; long-chain fatty acid adenylase/transferase FadD26 [EC:6.2.1.59] 545.0 3.0 0.0 1.0 1.0 IQ 0.0 3.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 3.0 0.0 1.0 0 0 0 0 K12427 0.0 0.0056980056980056 fadD28; long-chain fatty acid adenylyltransferase FadD28 [EC:6.2.1.49] 567.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 2.0 0.0 1.0 0 0 0 0 K12428 0.0 0.0113960113960113 fadD32; fatty acid CoA ligase FadD32 564.0 10.0 0.0 1.0 1.0 IQ 0.0 10.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 10.0 0.0 1.0 0.0004835698594401 0.0021813657565982 0.0013324678080191 0.0016977958971581 0 0 0 0 K12429 0.0 0.0313390313390313 fadD36; fatty acid CoA ligase FadD36 444.0 13.0 0.0 1.0 1.0 IQ 0.0 13.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 13.0 0.0 1.0 0.0020235310557639 0.01156225973575 0.0067928953957569 0.009538728679986 0 0 0 0 K12430 0.0 0.0085470085470085 pks1_15; 4-hydroxyphenylalkanoate synthase [EC:2.3.1.261] 3428.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 3.0 0.0 1.0 0 0 0 0 K12431 0.0 0.0085470085470085 pks2; phthioceranic/hydroxyphthioceranic acid synthase [EC:2.3.1.287] 1974.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 2.0 0.75 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 4.0 0.0 1.0 4.16766064626299e-07 3.08420564760087e-06 1.7504858561135843e-06 2.667439582974571e-06 0 0 0 0 K12432 0.0 0.0056980056980056 pks3_4; mycolipanoate synthase [EC:2.3.1.252] 2027.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 2.0 0.5 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 2.0 0.0 1.0 0 0 0 0 K12433 0.0 0.0085470085470085 pks5; polyketide synthase 5 1303.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 2.0 0.571428571428571 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 7.0 0.0 1.0 2.71705698187507e-08 2.82969337255161e-07 1.5506995353695585e-07 2.5579876743641025e-07 0 0 0 0 K12436 0.0 0.0199430199430199 pks12; mycoketide-CoA synthase [EC:2.3.1.295] 740.0 6.0 1.0 3.0 0.5 IQ 0.0 12.0 6.0 0.25 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 12.0 0.0 1.0 0.0030884511698961 0.0083865560440949 0.0057375036069955 0.0052981048741988 0 0 0 0 K12437 0.0 0.0113960113960113 pks13; polyketide synthase 13 1404.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 4.0 0.25 COG0236 Acyl_carrier_protein AcpP 4.0 0.0 1.0 0.0010881118434297 0.0086283728169157 0.0048582423301727 0.007540260973486 0 0 0 0 K12440 0.0 0.0028490028490028 ppsA; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase A [EC:2.3.1.292] 1363.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 2.0 0.0 1.0 0 0 0 0 K12441 0.0 0.0028490028490028 ppsB; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292] 1042.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 3.0 0.0 1.0 0 0 0 0 K12442 0.0 0.0085470085470085 ppsC; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292] 1974.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 2.0 0.75 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 4.0 0.0 1.0 4.16766064626299e-07 3.08420564760087e-06 1.7504858561135843e-06 2.667439582974571e-06 0 0 0 0 K12443 0.0 0.0227920227920227 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292] 364.0 7.0 4.0 2.0 0.7 Q 0.0 10.0 4.0 0.3 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 10.0 0.0 1.0 0.0019970023521319 0.0062324362306467 0.0041147192913893 0.0042354338785147 0 0 0 0 K12444 0.0 0.0085470085470085 ppsE; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292] 361.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K12445 0.0 0.0142450142450142 K12445; trans enoyl reductase [EC:1.3.1.-] 403.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3268 Uncharacterized_conserved_protein,_related_to_short-chain_dehydrogenases 5.0 0.0 1.0 4.45184595735223e-05 0.0004500946543361 0.0002473065569548 0.0004055761947625 0 0 0 0 K12446 0.0 0.0085470085470085 E2.7.1.46; L-arabinokinase [EC:2.7.1.46] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 227.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG0153 Galactokinase GalK 3.0 0.0 1.0 0 0 0 0 K12447 0.0 0.0028490028490028 USP; UDP-sugar pyrophosphorylase [EC:2.7.7.64] path:map00040,path:map00052,path:map00053,path:map00520,path:map01100,path:map01110,path:map01250 Pentose and glucuronate interconversions,Galactose metabolism,Ascorbate and aldarate metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 483.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG4284 UDP-N-acetylglucosamine_pyrophosphorylase QRI1 1.0 0.0 1.0 0 0 0 0 K12448 0.0 0.074074074074074 UXE, uxe; UDP-arabinose 4-epimerase [EC:5.1.3.5] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 305.0 27.0 0.0 1.0 1.0 M 0.0 27.0 1.0 1.0 COG1087 UDP-glucose_4-epimerase GalE 27.0 0.0 1.0 0.0323221850637814 0.0618565481921389 0.0470893666279601 0.0295343631283575 0 0 0 0 K12449 0.0 0.0313390313390313 AXS; UDP-apiose/xylose synthase path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 311.0 10.0 9.0 3.0 0.833333333333333 GM 0.0 12.0 2.0 0.916666666666667 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 12.0 0.0 1.0 0.0363017421884834 0.318421028120211 0.1773613851543472 0.2821192859317276 0 0 0 0 K12450 0.0114285714285714 0.0683760683760683 RHM; UDP-glucose 4,6-dehydratase [EC:4.2.1.76] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 283.0 30.0 29.0 2.0 0.967741935483871 M 4.0 27.0 1.0 1.0 COG1088 dTDP-D-glucose_4,6-dehydratase RfbB 31.0 0.1290322580645161 0.8709677419354839 0.0068089353717253 0.013704559595116 0.0102567474834206 0.0068956242233906 0 0 0 0 K12451 0.0028571428571428 0.0113960113960113 UER1; 3,5-epimerase/4-reductase [EC:5.1.3.- 1.1.1.-] path:map00520,path:map00523,path:map01100,path:map01110,path:map01250 Amino sugar and nucleotide sugar metabolism,Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 269.0 4.0 2.0 2.0 0.666666666666667 G 1.0 5.0 1.0 1.0 COG1088 dTDP-D-glucose_4,6-dehydratase RfbB 6.0 0.1666666666666666 0.8333333333333334 0.0286891253442236 0.66821417865757 0.3484516520008968 0.6395250533133464 0 0 0 0 K12452 0.0685714285714285 0.1566951566951566 ascC, ddhC, rfbH; CDP-4-dehydro-6-deoxyglucose reductase, E1 [EC:1.17.1.1] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 268.0 69.0 43.0 3.0 0.71875 E 30.0 65.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 95.0 0.3157894736842105 0.6842105263157895 0.025550274224839 0.134931384252976 0.0802408292389074 0.109381110028137 0 0 0 0 K12453 0.0 0.0113960113960113 rfbS; CDP-paratose synthetase [EC:1.1.1.342] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 270.0 4.0 0.0 1.0 1.0 GM 0.0 4.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 4.0 0.0 1.0 0.109689976084124 0.223051819737164 0.166370897910644 0.11336184365304 0 0 0 0 K12454 0.0885714285714285 0.1225071225071225 rfbE; CDP-paratose 2-epimerase [EC:5.1.3.10] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 232.0 74.0 55.0 2.0 0.795698924731183 M 32.0 61.0 2.0 0.946236559139785 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 93.0 0.3440860215053763 0.6559139784946236 0.533706437610002 0.806493771747387 0.6701001046786945 0.272787334137385 0 1 0 1 K12466 0.0 0.0085470085470085 E1.1.1.275; (+)-trans-carveol dehydrogenase [EC:1.1.1.275] path:map00903,path:map01110 Limonene and pinene degradation,Biosynthesis of secondary metabolites 278.0 3.0 0.0 1.0 1.0 IQ 0.0 3.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 3.0 0.0 1.0 0 0 0 0 K12472 0.0 0.0085470085470085 EPS15; epidermal growth factor receptor substrate 15 path:map04144 Endocytosis 554.0 1.0 0.0 2.0 0.5 Q 0.0 3.0 3.0 0.333333333333333 COG1511 Uncharacterized_membrane_protein_YhgE,_phage_infection_protein_(PIP)_family YhgE 3.0 0.0 1.0 0 0 0 0 K12500 0.0 0.0455840455840455 tesC; thioesterase III [EC:3.1.2.-] 107.0 13.0 9.0 2.0 0.764705882352941 S 0.0 17.0 1.0 1.0 COG0824 Acyl-CoA_thioesterase_FadM FadM 17.0 0.0 1.0 0.0219017449727267 0.0601587894554344 0.0410302672140805 0.0382570444827077 0 0 0 0 K12501 0.0028571428571428 0.0 HST; homogentisate solanesyltransferase [EC:2.5.1.117] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 332.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 1.0 1.0 0.0 0 0 0 0 K12503 0.0028571428571428 0.1253561253561253 E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase [EC:2.5.1.68] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 207.0 41.0 35.0 2.0 0.872340425531915 I 1.0 46.0 1.0 1.0 COG0020 Undecaprenyl_pyrophosphate_synthase UppS 47.0 0.0212765957446808 0.9787234042553192 0.0025146822752132 0.0939059611837781 0.0482103217294956 0.0913912789085649 0 0 0 0 K12506 0.0028571428571428 0.5014245014245015 ispDF; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:2.7.7.60 4.6.1.12] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 133.0 161.0 122.0 3.0 0.781553398058252 I 1.0 198.0 3.0 0.87378640776699 COG0245 2C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase IspF 199.0 0.0050251256281407 0.9949748743718592 0.404122722128195 0.10093834040417 0.2525305312661825 0.303184381724025 0 0 0 0 K12507 0.0 0.0427350427350427 fadK; acyl-CoA synthetase [EC:6.2.1.-] 418.0 17.0 0.0 1.0 1.0 IQ 0.0 17.0 2.0 0.941176470588235 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 17.0 0.0 1.0 0.0094867583533501 0.0623532444238866 0.0359200013886183 0.0528664860705365 0 0 0 0 K12508 0.0028571428571428 0.0512820512820512 fcs; feruloyl-CoA synthase [EC:6.2.1.34] 377.0 38.0 0.0 1.0 1.0 IQ 1.0 37.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 38.0 0.0263157894736842 0.9736842105263158 0.0117857848777738 0.0066237702767654 0.0092047775772696 0.0051620146010084 0 0 0 0 K12510 0.0057142857142857 0.2877492877492877 tadB; tight adherence protein B 86.0 138.0 113.0 2.0 0.846625766871166 U 2.0 163.0 5.0 0.824242424242424 COG4965 Flp_pilus_assembly_protein_TadB TadB 165.0 0.0121212121212121 0.987878787878788 0.0269493367317215 0.793769262210996 0.4103592994713587 0.7668199254792745 0 0 0 0 K12511 0.0 0.2792022792022792 tadC; tight adherence protein C 122.0 127.0 124.0 4.0 0.962121212121212 NU 0.0 132.0 5.0 0.878787878787879 COG2064 Flp_pilus_assembly_protein_TadC TadC 132.0 0.0 1.0 0.0090351618079507 0.885400392115916 0.4472177769619334 0.8763652303079653 0 0 0 0 K12512 0.0 0.0028490028490028 tadD; tight adherence protein D 238.0 2.0 0.0 1.0 1.0 U 0.0 2.0 1.0 1.0 COG5010 Flp_pilus_assembly_protein_TadD,_contains_TPR_repeats TadD 2.0 0.0 1.0 0 0 0 0 K12513 0.0 0.0113960113960113 tadE; tight adherence protein E 113.0 5.0 0.0 1.0 1.0 U 0.0 5.0 1.0 1.0 COG4961 Flp_pilus_assembly_protein_TadG,_includes_N-terminal_TadE_domain TadG 5.0 0.0 1.0 0.128245532461724 0.204394075732385 0.1663198040970545 0.076148543270661 0 0 0 0 K12514 0.0 0.0028490028490028 tadF; tight adherence protein F 178.0 2.0 0.0 1.0 1.0 S 0.0 2.0 2.0 0.5 2FBPR 2.0 0.0 1.0 0 0 0 0 K12515 0.0 0.0056980056980056 tadG; tight adherence protein G 186.0 2.0 1.0 2.0 0.666666666666667 U 0.0 3.0 1.0 1.0 COG2304 Secreted_protein_containing_bacterial_Ig-like_domain_and_vWFA_domain YfbK 3.0 0.0 1.0 0 0 0 0 K12516 0.0 0.0142450142450142 bigA; putative surface-exposed virulence protein 289.0 2.0 1.0 3.0 0.5 U 0.0 5.0 5.0 0.2 COG4625 Uncharacterized_conserved_protein,_contains_a_C-terminal_beta-barrel_porin_domain 5.0 0.0 1.0 0.127003232723283 0.314566440408586 0.2207848365659345 0.187563207685303 0 0 0 0 K12524 0.0514285714285714 0.2849002849002849 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] path:map00260,path:map00261,path:map00270,path:map00300,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Monobactam biosynthesis,Cysteine and methionine metabolism,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 43.0 140.0 0.0 1.0 1.0 E 20.0 115.0 3.0 0.714285714285714 COG0460 Homoserine_dehydrogenase ThrA 135.0 0.1481481481481481 0.8518518518518519 0.0830532306170378 0.0129607448988616 0.0480069877579497 0.0700924857181762 0 0 0 0 K12525 0.0 0.017094017094017 metL; bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3] path:map00260,path:map00261,path:map00270,path:map00300,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Monobactam biosynthesis,Cysteine and methionine metabolism,Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 780.0 9.0 0.0 1.0 1.0 E 0.0 9.0 1.0 1.0 COG0460 Homoserine_dehydrogenase ThrA 9.0 0.0 1.0 0.114366106893376 0.0173057696571491 0.0658359382752625 0.0970603372362269 0 0 0 0 K12526 0.0 0.0256410256410256 lysAC; bifunctional diaminopimelate decarboxylase / aspartate kinase [EC:4.1.1.20 2.7.2.4] path:map00260,path:map00261,path:map00270,path:map00300,path:map00470,path:map01100,path:map01110,path:map01120,path:map01230 Glycine, serine and threonine metabolism,Monobactam biosynthesis,Cysteine and methionine metabolism,Lysine biosynthesis,D-Amino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of amino acids 353.0 11.0 0.0 1.0 1.0 E 0.0 10.0 2.0 0.818181818181818 COG0019 Diaminopimelate_decarboxylase LysA 10.0 0.0 1.0 0.0345222217766656 0.0878046882601968 0.0611634550184312 0.0532824664835312 0 0 0 0 K12527 0.0085714285714285 0.0626780626780626 ygfK; putative selenate reductase [EC:1.97.1.9] path:map00450 Selenocompound metabolism 50.0 25.0 21.0 2.0 0.862068965517241 C 4.0 25.0 7.0 0.551724137931035 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 29.0 0.1379310344827586 0.8620689655172413 0.570231042457421 0.571182462443041 0.570706752450231 0.00095141998562 0 0 0 1 K12528 0.0114285714285714 0.0341880341880341 xdhD; putative selenate reductase molybdopterin-binding subunit path:map00450 Selenocompound metabolism 527.0 20.0 19.0 2.0 0.952380952380952 C 5.0 14.0 2.0 0.952380952380952 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 19.0 0.2631578947368421 0.7368421052631579 0.979176315709454 0.997782160897434 0.988479238303444 0.01860584518798 1 1 1 1 K12529 0.0 0.017094017094017 ygfM; putative selenate reductase FAD-binding subunit path:map00450 Selenocompound metabolism 247.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 6.0 0.0 1.0 0.0169183065257718 0.666797376715278 0.3418578416205248 0.6498790701895062 0 0 0 0 K12532 0.0 0.0056980056980056 rtxD, fitB; membrane fusion protein, RTX toxin transport system path:map02020 Two-component system 441.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 2.0 0.0 1.0 0 0 0 0 K12533 0.0 0.0056980056980056 572.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG4618 ABC-type_protease/lipase_transport_system,_ATPase_and_permease_components ArpD 2.0 0.0 1.0 0 0 0 0 K12534 0.0 0.0028490028490028 471.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 1.0 0.0 1.0 0 0 0 0 K12535 0.0 0.0227920227920227 442.0 8.0 0.0 1.0 1.0 MU 0.0 8.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 8.0 0.0 1.0 3.32321908775659e-12 5.20629134039104e-08 2.603311831149908e-08 5.205959018482264e-08 0 0 0 0 K12536 0.0 0.0227920227920227 hasD, prtD, aprD, rsaD, prsD, eexD; ATP-binding cassette, subfamily C, type I secretion system permease/ATPase path:map02010 ABC transporters 552.0 13.0 0.0 1.0 1.0 V 0.0 13.0 1.0 1.0 COG4618 ABC-type_protease/lipase_transport_system,_ATPase_and_permease_components ArpD 13.0 0.0 1.0 0.0163373945367777 0.043993658254959 0.0301655263958683 0.0276562637181813 0 0 0 0 K12537 0.0 0.0199430199430199 hasE, prtE, rsaE, prsE, eexE; membrane fusion protein, type I secretion system 306.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 8.0 0.0 1.0 0.0563288061621776 0.0462855979717588 0.0513072020669682 0.0100432081904187 0 0 0 0 K12538 0.0 0.0284900284900284 hasF, prtF; outer membrane protein, type I secretion system 310.0 13.0 0.0 1.0 1.0 MU 0.0 13.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 13.0 0.0 1.0 0.771903341505534 0.337091562041744 0.554497451773639 0.4348117794637899 0 0 1 1 K12541 0.0 0.1025641025641025 lapB; ATP-binding cassette, subfamily C, bacterial LapB path:map02010 ABC transporters 443.0 40.0 35.0 3.0 0.869565217391304 V 0.0 50.0 2.0 0.92 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 50.0 0.0 1.0 0.015081427544084 0.0309614603455988 0.0230214439448414 0.0158800328015148 0 0 0 0 K12542 0.0 0.1054131054131054 lapC; membrane fusion protein, adhesin transport system 283.0 46.0 44.0 3.0 0.938775510204082 M 0.0 49.0 2.0 0.959183673469388 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 49.0 0.0 1.0 0.0099886335933021 0.0223146047185143 0.0161516191559082 0.0123259711252121 0 0 0 0 K12543 0.0 0.1168091168091168 lapE; outer membrane protein, adhesin transport system 139.0 53.0 50.0 3.0 0.929824561403509 MU 0.0 57.0 3.0 0.947368421052632 COG1538 Outer_membrane_protein_TolC TolC 57.0 0.0 1.0 0.0132260721562656 0.0396199700452114 0.0264230211007385 0.0263938978889458 0 0 0 0 K12544 0.0 0.0028490028490028 rsaA; S-layer protein 1144.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2931 Ca2+-binding_protein,_RTX_toxin-related 1.0 0.0 1.0 0 0 0 0 K12548 0.0114285714285714 0.0313390313390313 rap; autoaggregation protein RapA/B/C 62.0 6.0 1.0 5.0 0.3 U 5.0 14.0 6.0 0.25 COG2373 Uncharacterized_conserved_protein_YfaS,_alpha-2-macroglobulin_family YfaS 19.0 0.2631578947368421 0.7368421052631579 0.0795045681561753 0.548001199781309 0.3137528839687422 0.4684966316251337 0 0 0 0 K12549 0.0 0.017094017094017 lapA; surface adhesion protein 557.0 3.0 2.0 4.0 0.5 K 0.0 6.0 4.0 0.5 COG5625 Predicted_DNA-binding_transcriptional_regulator,_contains_HTH_domain 6.0 0.0 1.0 0.0639750858679526 0.138011627621687 0.1009933567448198 0.0740365417537344 0 0 0 0 K12551 0.0 0.0427350427350427 sgtA; monofunctional glycosyltransferase [EC:2.4.1.129] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 579.0 18.0 0.0 1.0 1.0 M 0.0 18.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 18.0 0.0 1.0 0.0017596058106291 0.0034072215378885 0.0025834136742588 0.0016476157272594 0 0 0 0 K12552 0.0 0.0997150997150997 pbpA; penicillin-binding protein 1 [EC:3.4.-.-] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 349.0 35.0 0.0 1.0 1.0 M 0.0 35.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 35.0 0.0 1.0 0.40406023727833 0.482445225512775 0.4432527313955525 0.078384988234445 0 0 0 0 K12553 0.0 0.037037037037037 pbp3; penicillin-binding protein 3 [EC:3.4.-.-] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 616.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 13.0 0.0 1.0 0.004493712199438 0.0033380308669009 0.0039158715331694 0.0011556813325371 0 0 0 0 K12554 0.0028571428571428 0.017094017094017 murN; alanine adding enzyme [EC:2.3.2.-] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 270.0 9.0 0.0 1.0 1.0 V 1.0 8.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 9.0 0.1111111111111111 0.8888888888888888 0.0304113679480102 0.67407001497788 0.3522406914629451 0.6436586470298697 0 0 0 0 K12555 0.0 0.0683760683760683 pbp2A; penicillin-binding protein 2A [EC:2.4.1.129 3.4.16.4] path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 466.0 36.0 0.0 1.0 1.0 M 0.0 36.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 36.0 0.0 1.0 0.965621505740409 0.661373960696705 0.8134977332185569 0.304247545043704 0 0 1 1 K12556 0.0 0.0997150997150997 pbp2X; penicillin-binding protein 2X path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 349.0 35.0 0.0 1.0 1.0 M 0.0 35.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 35.0 0.0 1.0 0.526124258652805 0.608247202392565 0.5671857305226851 0.08212294373976 0 0 0 1 K12567 0.0371428571428571 0.0284900284900284 TTN; titin [EC:2.7.11.1] path:map05410,path:map05414 Hypertrophic cardiomyopathy,Dilated cardiomyopathy 48.0 20.0 15.0 8.0 0.540540540540541 C 24.0 12.0 9.0 0.432432432432432 COG3794 Plastocyanin PetE 36.0 0.6666666666666666 0.3333333333333333 0.892598455356888 0.792184973560994 0.842391714458941 0.1004134817958939 1 1 1 1 K12570 0.0 0.0085470085470085 aphD, strA; streptomycin 6-kinase [EC:2.7.1.72] path:map00521,path:map01100,path:map01110 Streptomycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 303.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG3570 Streptomycin_6-kinase StrB 3.0 0.0 1.0 0 0 0 0 K12573 0.1371428571428571 0.698005698005698 rnr, vacB; ribonuclease R [EC:3.1.13.1] path:map03018 RNA degradation 219.0 165.0 18.0 4.0 0.523809523809524 K 50.0 265.0 4.0 0.984126984126984 COG0557 Exoribonuclease_R VacB 315.0 0.1587301587301587 0.8412698412698413 0.0067671993315297 0.0160947410037216 0.0114309701676256 0.0093275416721918 0 0 0 0 K12574 0.5742857142857143 0.6524216524216524 rnj; ribonuclease J [EC:3.1.-.-] path:map03018 RNA degradation 198.0 292.0 86.0 5.0 0.555133079847909 J 248.0 278.0 2.0 0.996197718631179 COG0595 mRNA_degradation_ribonuclease_J1/J2 RnjA 526.0 0.4714828897338403 0.5285171102661597 0.981395861862985 0.991035277863565 0.9862155698632752 0.00963941600058 1 1 1 1 K12582 0.0 0.0199430199430199 wecF, rffT; dTDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase [EC:2.4.1.325] path:map00543 Exopolysaccharide biosynthesis 313.0 3.0 1.0 4.0 0.428571428571429 C 0.0 7.0 3.0 0.571428571428571 COG0554 Glycerol_kinase GlpK 7.0 0.0 1.0 0.0734027507198828 0.0466269035180839 0.0600148271189833 0.0267758472017988 0 0 0 0 K12583 0.0 0.0541310541310541 mgtA; phosphatidylinositol alpha 1,6-mannosyltransferase [EC:2.4.1.-] 337.0 19.0 0.0 1.0 1.0 M 0.0 19.0 2.0 0.842105263157895 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 19.0 0.0 1.0 0.0096863457717682 0.0211269203956338 0.015406633083701 0.0114405746238656 0 0 0 0 K12585 0.0 0.1082621082621082 DIS3, RRP44; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-] path:map03018 RNA degradation 589.0 22.0 6.0 2.0 0.578947368421053 J 0.0 38.0 1.0 1.0 COG0557 Exoribonuclease_R VacB 38.0 0.0 1.0 0.0167244717872102 0.0254974246287689 0.0211109482079895 0.0087729528415586 0 0 0 0 K12589 0.8142857142857143 0.0 RRP42, EXOSC7; exosome complex component RRP42 path:map03018 RNA degradation 199.0 289.0 0.0 1.0 1.0 J 289.0 0.0 1.0 1.0 COG2123 Exosome_complex_RNA-binding_protein_Rrp42,_RNase_PH_superfamily Rrp42 289.0 1.0 0.0 0.886224794763321 0.743797318762747 0.815011056763034 0.142427476000574 0 0 1 1 K12600 0.0028571428571428 0.0056980056980056 SKI3, TTC37; superkiller protein 3 path:map03018 RNA degradation 120.0 1.0 0.0 3.0 0.333333333333333 O 1.0 2.0 2.0 0.666666666666667 KOG1127 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K12601 0.0 0.0028490028490028 SKI8; superkiller protein 8 path:map03018 RNA degradation 344.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0333 Ribosomal_protein_L32 RpmF 1.0 0.0 1.0 0 0 0 0 K12602 0.0 0.0056980056980056 WDR61, REC14, SKI8; WD repeat-containing protein 61 path:map03018 RNA degradation 222.0 1.0 0.0 2.0 0.5 J 0.0 2.0 2.0 0.5 COG0333 Ribosomal_protein_L32 RpmF 2.0 0.0 1.0 0 0 0 0 K12614 0.0028571428571428 0.0 DDX6, RCK, DHH1; ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.4.13] path:map03018 RNA degradation 653.0 1.0 0.0 1.0 1.0 D 1.0 0.0 1.0 1.0 COG1196 Chromosome_segregation_ATPase_Smc Smc 1.0 1.0 0.0 0 0 0 0 K12615 0.0 0.0028490028490028 EDC3; enhancer of mRNA-decapping protein 3 path:map03018 RNA degradation 236.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0062 NAD(P)H-hydrate_repair_enzyme_Nnr,_NAD(P)H-hydrate_epimerase_domain Nnr1 1.0 0.0 1.0 0 0 0 0 K12619 0.0028571428571428 0.0 XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-] path:map03008,path:map03018 Ribosome biogenesis in eukaryotes,RNA degradation 329.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 1.0 1.0 0.0 0 0 0 0 K12622 0.0028571428571428 0.0 LSM3; U6 snRNA-associated Sm-like protein LSm3 path:map03018,path:map03040 RNA degradation,Spliceosome 79.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 KOG3460 1.0 1.0 0.0 0 0 0 0 K12625 0.0085714285714285 0.0 LSM6; U6 snRNA-associated Sm-like protein LSm6 path:map03018,path:map03040 RNA degradation,Spliceosome 65.0 3.0 0.0 1.0 1.0 A 3.0 0.0 1.0 1.0 COG1958 Small_nuclear_ribonucleoprotein_(snRNP)_homolog LSM1 3.0 1.0 0.0 0 0 0 0 K12646 0.0 0.0028490028490028 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13] path:map04064,path:map04622,path:map04623,path:map05160,path:map05161,path:map05162,path:map05164,path:map05168,path:map05169,path:map05171 NF-kappa B signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Hepatitis C,Hepatitis B,Measles,Influenza A,Herpes simplex virus 1 infection,Epstein-Barr virus infection,Coronavirus disease - COVID-19 326.0 1.0 0.0 1.0 1.0 A 0.0 1.0 1.0 1.0 COG1111 ERCC4-related_helicase MPH1 1.0 0.0 1.0 0 0 0 0 K12647 0.0 0.0028490028490028 IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13] path:map04622,path:map05161,path:map05162,path:map05164,path:map05168,path:map05171 RIG-I-like receptor signaling pathway,Hepatitis B,Measles,Influenza A,Herpes simplex virus 1 infection,Coronavirus disease - COVID-19 326.0 1.0 0.0 1.0 1.0 A 0.0 1.0 1.0 1.0 COG1111 ERCC4-related_helicase MPH1 1.0 0.0 1.0 0 0 0 0 K12658 0.0 0.0854700854700854 lhpA; 4-hydroxyproline epimerase [EC:5.1.1.8] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 287.0 31.0 0.0 1.0 1.0 E 0.0 31.0 1.0 1.0 COG3938 Proline_racemase/hydroxyproline_epimerase PrdF 31.0 0.0 1.0 0.025365918739848 0.0829557574279619 0.0541608380839049 0.0575898386881138 0 0 0 0 K12659 0.0 0.0028490028490028 ARG56; N-acetyl-gamma-glutamyl-phosphate reductase / acetylglutamate kinase [EC:1.2.1.38 2.7.2.8] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 824.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0002 N-acetyl-gamma-glutamylphosphate_reductase ArgC 1.0 0.0 1.0 0 0 0 0 K12660 0.0085714285714285 0.0455840455840455 rhmA; 2-dehydro-3-deoxy-L-rhamnonate aldolase [EC:4.1.2.53] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 206.0 25.0 24.0 3.0 0.925925925925926 G 3.0 24.0 1.0 1.0 COG3836 2-keto-3-deoxy-L-rhamnonate_aldolase_RhmA HpcH 27.0 0.1111111111111111 0.8888888888888888 0.0195399825812821 0.033899916992414 0.026719949786848 0.0143599344111319 0 0 0 0 K12661 0.0171428571428571 0.0227920227920227 LRA3, rhmD; L-rhamnonate dehydratase [EC:4.2.1.90] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 353.0 16.0 15.0 2.0 0.941176470588235 M 6.0 11.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 17.0 0.3529411764705882 0.6470588235294118 0.0174193118831271 0.0398210597023111 0.028620185792719 0.0224017478191839 0 0 0 0 K12663 0.0 0.0028490028490028 ECH1; Delta3,5-Delta2,4-dienoyl-CoA isomerase [EC:5.3.3.21] path:map04146 Peroxisome 177.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0221 Inorganic_pyrophosphatase Ppa 1.0 0.0 1.0 0 0 0 0 K12666 0.0028571428571428 0.0 OST1, RPN1; oligosaccharyltransferase complex subunit alpha (ribophorin I) path:map00510,path:map00513,path:map01100,path:map04141 N-Glycan biosynthesis,Various types of N-glycan biosynthesis,Metabolic pathways,Protein processing in endoplasmic reticulum 622.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG2291 1.0 1.0 0.0 0 0 0 0 K12675 0.0 0.0028490028490028 cs; clavaminate synthase [EC:1.14.11.21] path:map00331,path:map01100,path:map01110 Clavulanic acid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 330.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 2.0 0.0 1.0 0 0 0 0 K12676 0.0 0.0056980056980056 pah; proclavaminate amidinohydrolase [EC:3.5.3.22] path:map00331,path:map01100,path:map01110 Clavulanic acid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 310.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0010 Arginase/agmatinase_family_enzyme SpeB 2.0 0.0 1.0 0 0 0 0 K12677 0.0 0.0028490028490028 car; clavulanate-9-aldehyde reducatase path:map00331,path:map01100,path:map01110 Clavulanic acid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 61.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 1.0 0.0 1.0 0 0 0 0 K12678 0.0 0.0056980056980056 aidA-I, misL; autotransporter family porin 323.0 4.0 3.0 2.0 0.8 MU 0.0 5.0 2.0 0.6 COG3468 Autotransporter_adhesin_AidA AidA 5.0 0.0 1.0 7.63467153719626e-12 1.37640912906446e-11 1.069938141392043e-11 6.12941975344834e-12 0 0 0 0 K12684 0.0 0.0142450142450142 esp, sigA, sepA; serine protease autotransporter [EC:3.4.21.-] 264.0 2.0 0.0 3.0 0.4 Q 0.0 5.0 4.0 0.4 COG1511 Uncharacterized_membrane_protein_YhgE,_phage_infection_protein_(PIP)_family YhgE 5.0 0.0 1.0 0.841636278616153 0.0678309009496803 0.4547335897829166 0.7738053776664726 0 0 1 1 K12685 0.0142857142857142 0.0427350427350427 ssp; subtilase-type serine protease [EC:3.4.21.-] 55.0 14.0 11.0 5.0 0.666666666666667 O 6.0 15.0 3.0 0.761904761904762 COG1404 Serine_protease,_subtilisin_family AprE 21.0 0.2857142857142857 0.7142857142857143 0.248856342846203 0.0742406699364764 0.1615485063913397 0.1746156729097266 0 0 0 0 K12686 0.0 0.0398860398860398 apeE, estA, lip-1; outer membrane lipase/esterase 149.0 12.0 9.0 5.0 0.631578947368421 I 0.0 16.0 2.0 0.842105263157895 COG3240 Phospholipase/lecithinase/hemolysin 16.0 0.0 1.0 0.0075516718996408 0.0404595172702588 0.0240055945849498 0.032907845370618 0 0 0 0 K12687 0.0 0.0028490028490028 flu; antigen 43 path:map02026 Biofilm formation - Escherichia coli 1039.0 1.0 0.0 1.0 1.0 MU 0.0 1.0 1.0 1.0 COG3468 Autotransporter_adhesin_AidA AidA 1.0 0.0 1.0 0 0 0 0 K12688 0.0 0.0028490028490028 sphB1, nalP, ausP; autotransporter serine protease [EC:3.4.21.-] path:map05133 Pertussis 129.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 1.0 0.0 1.0 0 0 0 0 K12700 0.0028571428571428 0.0284900284900284 rihC; non-specific riboncleoside hydrolase [EC:3.2.2.-] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 288.0 12.0 0.0 1.0 1.0 F 1.0 11.0 1.0 1.0 COG1957 Inosine-uridine_nucleoside_N-ribohydrolase URH1 12.0 0.0833333333333333 0.9166666666666666 0.147384684639439 0.265739608589394 0.2065621466144165 0.118354923949955 0 0 0 0 K12710 0.0 0.0142450142450142 novU; C-methyltransferase [EC:2.1.1.-] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 226.0 5.0 0.0 1.0 1.0 H 0.0 5.0 1.0 1.0 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 5.0 0.0 1.0 0.119894692115477 0.260878627684944 0.1903866599002105 0.140983935569467 0 0 0 0 K12857 0.0 0.0028490028490028 SNRNP40, PRP8BP; Prp8 binding protein path:map03040 Spliceosome 363.0 1.0 0.0 1.0 1.0 A 0.0 1.0 1.0 1.0 KOG0265 1.0 0.0 1.0 0 0 0 0 K12885 0.0028571428571428 0.0028490028490028 RBMX, HNRNPG; heterogeneous nuclear ribonucleoprotein G path:map03040 Spliceosome 80.0 2.0 0.0 1.0 1.0 A 1.0 1.0 1.0 1.0 KOG0118 2.0 0.5 0.5 0 0 0 0 K12940 0.1314285714285714 0.0512820512820512 abgA; aminobenzoyl-glutamate utilization protein A 385.0 100.0 89.0 2.0 0.900900900900901 S 92.0 19.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 111.0 0.8288288288288288 0.1711711711711711 0.0053417039911781 0.450019634628253 0.2276806693097155 0.4446779306370749 0 0 0 0 K12941 0.0828571428571428 0.0997150997150997 abgB; aminobenzoyl-glutamate utilization protein B 306.0 66.0 42.0 2.0 0.733333333333333 S 39.0 51.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 90.0 0.4333333333333333 0.5666666666666667 0.0509707546917246 0.789161518190267 0.4200661364409958 0.7381907634985424 0 0 0 0 K12942 0.0 0.1111111111111111 abgT; aminobenzoyl-glutamate transport protein 467.0 57.0 0.0 1.0 1.0 H 0.0 57.0 1.0 1.0 COG2978 p-Aminobenzoyl-glutamate_transporter_AbgT AbgT 57.0 0.0 1.0 0.047049798024833 0.79363182083753 0.4203408094311815 0.746582022812697 0 0 0 0 K12943 0.0 0.0227920227920227 ygeR; lipoprotein YgeR 143.0 3.0 0.0 3.0 0.333333333333333 DM 0.0 9.0 2.0 0.666666666666667 COG1388 LysM_repeat LysM 9.0 0.0 1.0 7.03850382403982e-12 6.28598947824844e-05 3.142995091049411e-05 6.285988774398057e-05 0 0 0 0 K12944 0.0314285714285714 0.0142450142450142 nudI; nucleoside triphosphatase [EC:3.6.1.-] 110.0 15.0 13.0 2.0 0.882352941176471 F 12.0 5.0 2.0 0.882352941176471 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 17.0 0.7058823529411765 0.2941176470588235 0.0463423597140386 0.037340584195387 0.0418414719547128 0.0090017755186515 0 0 0 0 K12945 0.0 0.0113960113960113 nudK; GDP-mannose pyrophosphatase NudK [EC:3.6.1.-] 143.0 4.0 0.0 1.0 1.0 L 0.0 4.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 4.0 0.0 1.0 0.104177057997317 0.175675760034834 0.1399264090160755 0.071498702037517 0 0 0 0 K12949 0.0 0.0113960113960113 ctpB; cation-transporting P-type ATPase B [EC:7.2.2.-] 701.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 4.0 0.0 1.0 0.0240763428660869 0.0562057719304287 0.0401410573982578 0.0321294290643418 0 0 0 0 K12950 0.0 0.0569800569800569 ctpC; manganese-transporting P-type ATPase C [EC:7.2.2.22] 383.0 23.0 0.0 1.0 1.0 P 0.0 23.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 23.0 0.0 1.0 0.0361265623378112 0.121882452424067 0.0790045073809391 0.0857558900862558 0 0 0 0 K12951 0.0028571428571428 0.0085470085470085 ctpD; cobalt/nickel-transporting P-type ATPase D [EC:7.2.2.-] 585.0 4.0 3.0 2.0 0.8 P 1.0 4.0 2.0 0.8 COG2217 Cation-transporting_P-type_ATPase ZntA 5.0 0.2 0.8 0.0624307329998297 0.130206963989082 0.0963188484944558 0.0677762309892522 0 0 0 0 K12952 0.0628571428571428 0.0854700854700854 ctpE; cation-transporting P-type ATPase E [EC:7.2.2.-] 547.0 61.0 60.0 2.0 0.983870967741936 P 26.0 36.0 2.0 0.983870967741936 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 62.0 0.4193548387096774 0.5806451612903226 0.364306752400336 0.404901900637538 0.384604326518937 0.040595148237202 0 0 0 0 K12953 0.0 0.0142450142450142 ctpF; cation-transporting P-type ATPase F [EC:7.2.2.-] 857.0 6.0 0.0 1.0 1.0 P 0.0 6.0 1.0 1.0 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 6.0 0.0 1.0 0.0190679974309761 0.0295590546305434 0.0243135260307597 0.0104910571995673 0 0 0 0 K12954 0.0028571428571428 0.0256410256410256 ctpG; cation-transporting P-type ATPase G [EC:7.2.2.-] 356.0 21.0 0.0 1.0 1.0 P 1.0 19.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 20.0 0.05 0.95 0.00317432653341 0.0071024653160163 0.0051383959247131 0.0039281387826062 0 0 0 0 K12955 0.0 0.0569800569800569 ctpI; cation-transporting P-type ATPase I [EC:7.2.2.-] 721.0 20.0 0.0 1.0 1.0 P 0.0 20.0 2.0 0.85 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 20.0 0.0 1.0 0.0176481379533252 0.0365369776352216 0.0270925577942734 0.0188888396818964 0 0 0 0 K12956 0.0 0.0085470085470085 ctpV; copper-transporting P-type ATPase V [EC:7.2.2.8] 710.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 3.0 0.0 1.0 0 0 0 0 K12957 0.0085714285714285 0.0598290598290598 ahr; alcohol/geraniol dehydrogenase (NADP+) [EC:1.1.1.2 1.1.1.183] path:map00010,path:map00281,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Geraniol degradation,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 322.0 13.0 3.0 3.0 0.541666666666667 S 3.0 21.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 24.0 0.125 0.875 0.023448416776516 0.053922953677638 0.038685685227077 0.0304745369011219 0 0 0 0 K12960 0.5828571428571429 0.301994301994302 mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC:3.5.4.31 3.5.4.28] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 138.0 407.0 0.0 1.0 1.0 F 268.0 139.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 407.0 0.6584766584766585 0.3415233415233415 0.0550072398842472 0.936054791460127 0.4955310156721871 0.8810475515758799 0 0 0 0 K12961 0.0 0.0398860398860398 diaA; DnaA initiator-associating protein 184.0 16.0 15.0 3.0 0.888888888888889 G 0.0 18.0 1.0 1.0 COG0279 Phosphoheptose_isomerase GmhA 18.0 0.0 1.0 0.0156367703834362 0.0257178416261769 0.0206773060048065 0.0100810712427407 0 0 0 0 K12962 0.02 0.0427350427350427 arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE path:map01503 Cationic antimicrobial peptide (CAMP) resistance 87.0 14.0 6.0 4.0 0.5 P 10.0 18.0 4.0 0.571428571428571 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 28.0 0.3571428571428571 0.6428571428571429 0.0425908803090792 0.380828351326563 0.2117096158178211 0.3382374710174838 0 0 0 0 K12963 0.0057142857142857 0.0142450142450142 arnF; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnF path:map01503 Cationic antimicrobial peptide (CAMP) resistance 106.0 3.0 1.0 3.0 0.5 P 2.0 5.0 2.0 0.571428571428571 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 7.0 0.2857142857142857 0.7142857142857143 0.0027477856241859 0.002798942990103 0.0027733643071444 5.115736591710003e-05 0 0 0 0 K12972 0.0257142857142857 0.1367521367521367 ghrA; glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81] path:map00260,path:map00620,path:map00630,path:map01100,path:map01110,path:map01120 Glycine, serine and threonine metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 176.0 64.0 59.0 2.0 0.927536231884058 EH 11.0 58.0 1.0 1.0 COG0111 Phosphoglycerate_dehydrogenase_or_related_dehydrogenase SerA 69.0 0.1594202898550724 0.8405797101449275 0.155564123877683 0.0624535924754719 0.1090088581765774 0.0931105314022111 0 0 0 0 K12973 0.0 0.0199430199430199 pagP, crcA; lipid IVA palmitoyltransferase [EC:2.3.1.251] path:map00540,path:map01503,path:map05133 Lipopolysaccharide biosynthesis,Cationic antimicrobial peptide (CAMP) resistance,Pertussis 172.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 2C256 7.0 0.0 1.0 3.14457688653479e-07 8.52081646410462e-06 4.41763707637905e-06 8.206358775451142e-06 0 0 0 0 K12974 0.0 0.0284900284900284 lpxP; KDO2-lipid IV(A) palmitoleoyltransferase [EC:2.3.1.242] path:map00540 Lipopolysaccharide biosynthesis 291.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG1560 Palmitoleoyl-ACP:_Kdo2-lipid-IV_acyltransferase_(lipid_A_biosynthesis) LpxP 15.0 0.0 1.0 0.0057403024155387 0.0093545030012408 0.0075474027083897 0.003614200585702 0 0 0 0 K12975 0.0 0.0142450142450142 eptB; KDO II ethanolaminephosphotransferase [EC:2.7.8.42] path:map00540,path:map01503 Lipopolysaccharide biosynthesis,Cationic antimicrobial peptide (CAMP) resistance 212.0 7.0 5.0 2.0 0.777777777777778 S 0.0 9.0 1.0 1.0 COG2194 Phosphoethanolamine_transferase_for_periplasmic_glucans_OpgE,_AlkP_superfamily OpgE 9.0 0.0 1.0 0.002060027629124 0.0044358683039931 0.0032479479665585 0.002375840674869 0 0 0 0 K12976 0.0 0.0541310541310541 pagL; lipid A 3-O-deacylase [EC:3.1.1.-] path:map00540 Lipopolysaccharide biosynthesis 33.0 19.0 17.0 2.0 0.904761904761905 M 0.0 21.0 3.0 0.80952380952381 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 21.0 0.0 1.0 0.0691582971079579 0.107392048123822 0.0882751726158899 0.0382337510158641 0 0 0 0 K12977 0.0 0.0056980056980056 lpxE; lipid A 1-phosphatase [EC:3.1.3.-] path:map00540,path:map01100 Lipopolysaccharide biosynthesis,Metabolic pathways 131.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 2.0 0.0 1.0 0 0 0 0 K12978 0.0 0.0256410256410256 lpxF; lipid A 4'-phosphatase [EC:3.1.3.-] 204.0 5.0 1.0 2.0 0.555555555555556 I 0.0 9.0 2.0 0.555555555555556 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 9.0 0.0 1.0 0.0027427048015839 0.016600229187582 0.0096714669945829 0.0138575243859981 0 0 0 0 K12979 0.0 0.0541310541310541 lpxO; beta-hydroxylase [EC:1.14.11.-] path:map00540 Lipopolysaccharide biosynthesis 146.0 24.0 0.0 1.0 1.0 O 0.0 24.0 1.0 1.0 COG3555 Aspartyl/asparaginyl_beta-hydroxylase,_cupin_superfamily LpxO2 24.0 0.0 1.0 0.0627580926213708 0.0820900324430621 0.0724240625322164 0.0193319398216912 0 0 0 0 K12980 0.0 0.0455840455840455 lpxQ; lipid A oxidase 102.0 22.0 0.0 1.0 1.0 M 0.0 22.0 1.0 1.0 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 22.0 0.0 1.0 0.0133504166761289 0.0247945886766755 0.0190725026764022 0.0114441720005466 0 0 0 0 K12981 0.0 0.0056980056980056 waaZ, rfaZ; KDO transferase III [EC:2.4.99.-] path:map00540 Lipopolysaccharide biosynthesis 268.0 1.0 0.0 2.0 0.5 J 0.0 2.0 1.0 1.0 2DB7S 2.0 0.0 1.0 0 0 0 0 K12982 0.0 0.0797720797720797 opsX; heptosyltransferase I [EC:2.4.-.-] 176.0 32.0 31.0 2.0 0.96969696969697 M 0.0 33.0 1.0 1.0 COG0859 ADP-heptose:LPS_heptosyltransferase RfaF 33.0 0.0 1.0 0.0120451513599057 0.100628445629773 0.0563367984948393 0.0885832942698673 0 0 0 0 K12983 0.0 0.0056980056980056 waaV; UDP-glucose:(glucosyl)LPS beta-1,3-glucosyltransferase [EC:2.4.1.-] path:map00540 Lipopolysaccharide biosynthesis 290.0 2.0 0.0 1.0 1.0 M 0.0 2.0 2.0 0.5 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 2.0 0.0 1.0 0 0 0 0 K12984 0.0 0.1253561253561253 waaE, kdtX; (heptosyl)LPS beta-1,4-glucosyltransferase [EC:2.4.1.-] 156.0 42.0 36.0 2.0 0.875 M 0.0 48.0 3.0 0.8125 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 48.0 0.0 1.0 0.0227668522476944 0.147669871688341 0.0852183619680177 0.1249030194406466 0 0 0 0 K12985 0.0 0.0085470085470085 waaW; (galactosyl)LPS 1,2-glucosyltransferase [EC:2.4.1.-] path:map00540 Lipopolysaccharide biosynthesis 36.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG1442 Lipopolysaccharide_biosynthesis_protein,_LPS:glycosyltransferase RfaJ 4.0 0.0 1.0 2.42321987142995e-12 3.97354767884028e-09 1.987985449355855e-09 3.97112445896885e-09 0 0 0 0 K12986 0.0 0.0142450142450142 waaS, rfaS; 1,5-rhamnosyltransferase [EC:2.4.1.-] path:map00540 Lipopolysaccharide biosynthesis 230.0 5.0 0.0 1.0 1.0 M 0.0 5.0 3.0 0.6 COG4641 Spore_maturation_protein_CgeB 5.0 0.0 1.0 0.106717096110965 0.196316117392819 0.151516606751892 0.089599021281854 0 0 0 0 K12988 0.0028571428571428 0.0113960113960113 wapR; alpha-1,3-rhamnosyltransferase [EC:2.4.1.-] 252.0 3.0 0.0 2.0 0.5 M 1.0 5.0 2.0 0.666666666666667 COG1216 Glycosyltransferase,_GT2_family WcaE 6.0 0.1666666666666666 0.8333333333333334 0.0938119334569501 0.198678030294691 0.1462449818758205 0.1048660968377409 0 0 0 0 K12989 0.0 0.0313390313390313 lpcC; mannosyltransferase [EC:2.4.1.-] 314.0 9.0 8.0 3.0 0.818181818181818 M 0.0 11.0 2.0 0.909090909090909 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 11.0 0.0 1.0 0.0929746655282473 0.108718794466435 0.1008467299973411 0.0157441289381876 0 0 0 0 K12990 0.0457142857142857 0.0626780626780626 rfbF, rhlC; rhamnosyltransferase [EC:2.4.1.-] path:map02024,path:map02025 Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 83.0 17.0 2.0 3.0 0.386363636363636 M 19.0 25.0 2.0 0.977272727272727 COG1216 Glycosyltransferase,_GT2_family WcaE 44.0 0.4318181818181818 0.5681818181818182 0.139403481292982 0.246259687013409 0.1928315841531955 0.106856205720427 0 0 0 0 K12991 0.0028571428571428 0.0085470085470085 rfbG; rhamnosyltransferase [EC:2.4.1.-] 255.0 3.0 2.0 2.0 0.75 M 1.0 3.0 2.0 0.75 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 4.0 0.25 0.75 0.106246469283769 0.191013514097158 0.1486299916904635 0.084767044813389 0 0 0 0 K12992 0.0285714285714285 0.0655270655270655 rfbN, wbaN; O-antigen biosynthesis alpha-1,3-rhamnosyltransferase [EC:2.4.1.377] 142.0 16.0 4.0 4.0 0.470588235294118 S 10.0 24.0 4.0 0.735294117647059 COG1216 Glycosyltransferase,_GT2_family WcaE 34.0 0.2941176470588235 0.7058823529411765 0.0374122897737596 0.344922312447842 0.1911673011108008 0.3075100226740824 0 0 0 0 K12993 0.0028571428571428 0.0284900284900284 wbdA, mtfA; O-antigen biosynthesis alpha-1,2-mannosyltransferase [EC:2.4.1.371 2.4.1.-] path:map00542 O-Antigen repeat unit biosynthesis 296.0 10.0 8.0 2.0 0.833333333333333 M 1.0 11.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 12.0 0.0833333333333333 0.9166666666666666 0.0326586393376387 0.174385635571515 0.1035221374545768 0.1417269962338763 0 0 0 0 K12994 0.0285714285714285 0.0655270655270655 wbdB, mtfB; O-antigen biosynthesis alpha-1,3-mannosyltransferase [EC:2.4.1.349 2.4.1.-] 150.0 33.0 29.0 2.0 0.891891891891892 M 10.0 27.0 3.0 0.72972972972973 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 37.0 0.2702702702702703 0.7297297297297297 0.778694186804127 0.403139667977295 0.590916927390711 0.375554518826832 1 1 1 1 K12995 0.0657142857142857 0.0997150997150997 wbdC, mtfC; O-antigen biosynthesis alpha-1,3-mannosyltransferase [EC:2.4.1.348 2.4.1.-] 148.0 60.0 0.0 1.0 1.0 M 23.0 37.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 60.0 0.3833333333333333 0.6166666666666667 0.311142303154565 0.713750209850809 0.5124462565026869 0.4026079066962439 0 0 0 0 K12996 0.0342857142857142 0.037037037037037 rgpA; rhamnosyltransferase [EC:2.4.1.-] 200.0 27.0 0.0 1.0 1.0 M 12.0 15.0 2.0 0.962962962962963 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 27.0 0.4444444444444444 0.5555555555555556 0.103417120174033 0.0873016943566481 0.0953594072653405 0.0161154258173849 0 0 0 0 K12997 0.0028571428571428 0.0341880341880341 rgpB; rhamnosyltransferase [EC:2.4.1.-] 189.0 11.0 10.0 3.0 0.846153846153846 M 1.0 12.0 2.0 0.846153846153846 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 13.0 0.0769230769230769 0.9230769230769232 0.0948625929024667 0.275598583209658 0.1852305880560623 0.1807359903071913 0 0 0 0 K12998 0.0 0.0028490028490028 rgpE; glucosyltransferase [EC:2.4.1.-] 324.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 1.0 0.0 1.0 0 0 0 0 K12999 0.0028571428571428 0.0142450142450142 rgpI; glucosyltransferase [EC:2.4.1.-] 307.0 6.0 0.0 1.0 1.0 M 1.0 5.0 2.0 0.666666666666667 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 6.0 0.1666666666666666 0.8333333333333334 0.0170727209832503 0.0283716968100972 0.0227222088966737 0.0112989758268469 0 0 0 0 K13001 0.0 0.0142450142450142 wbyK; mannosyltransferase [EC:2.4.1.-] 342.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 5.0 0.0 1.0 0.0756548602405777 0.145163570570943 0.1104092154057603 0.0695087103303653 0 0 0 0 K13002 0.0028571428571428 0.0569800569800569 wbyL; glycosyltransferase [EC:2.4.1.-] 193.0 9.0 1.0 5.0 0.428571428571429 S 1.0 20.0 2.0 0.619047619047619 COG1216 Glycosyltransferase,_GT2_family WcaE 21.0 0.0476190476190476 0.9523809523809524 0.0491975830021779 0.0720013018414186 0.0605994424217982 0.0228037188392407 0 0 0 0 K13003 0.0 0.0142450142450142 wbtG; glycosyltransferase WbtG [EC:2.4.1.-] 373.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 5.0 0.0 1.0 0.101079273657376 0.207397578522455 0.1542384260899155 0.106318304865079 0 0 0 0 K13004 0.0 0.0227920227920227 wbtD; galacturonosyltransferase WbtD [EC:2.4.1.-] 346.0 9.0 0.0 1.0 1.0 M 0.0 9.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 9.0 0.0 1.0 0.0747296655631232 0.0641137984687697 0.0694217320159464 0.0106158670943534 0 0 0 0 K13005 0.0057142857142857 0.0313390313390313 rfbV, wbaV; O-antigen biosynthesis alpha-1,3-abequosyltransferase [EC:2.4.1.60] 174.0 7.0 2.0 3.0 0.538461538461538 M 2.0 11.0 2.0 0.538461538461538 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 13.0 0.1538461538461538 0.8461538461538461 0.308005078254657 0.231880156988167 0.269942617621412 0.07612492126649 0 0 0 0 K13006 0.0057142857142857 0.0484330484330484 wbqR; UDP-perosamine 4-acetyltransferase [EC:2.3.1.-] 152.0 7.0 0.0 3.0 0.368421052631579 GM 2.0 17.0 5.0 0.526315789473684 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 19.0 0.1052631578947368 0.8947368421052632 0.189783523179349 0.405610245416676 0.2976968842980125 0.215826722237327 0 0 0 0 K13007 0.0 0.0797720797720797 wbpL; glycosyltransferase WbpL [EC:2.4.1.-] 272.0 29.0 0.0 1.0 1.0 M 0.0 29.0 1.0 1.0 COG0472 UDP-N-acetylmuramyl_pentapeptide_phosphotransferase/UDP-N-acetylglucosamine-1-phosphate_transferase Rfe 29.0 0.0 1.0 0.615588883792665 0.380508400877366 0.4980486423350154 0.2350804829152989 0 0 0 1 K13008 0.0 0.0028490028490028 rfc, wbbH, wzyB; O-antigen polymerase [EC:2.4.1.-] 388.0 1.0 0.0 1.0 1.0 A 0.0 1.0 1.0 1.0 2DD48 1.0 0.0 1.0 0 0 0 0 K13009 0.0 0.0655270655270655 wzy; O-antigen polymerase [EC:2.4.1.-] 196.0 25.0 0.0 1.0 1.0 M 0.0 25.0 4.0 0.84 COG3307 O-antigen_ligase RfaL 25.0 0.0 1.0 0.961066625903048 0.712843715573953 0.8369551707385006 0.248222910329095 0 0 1 1 K13010 0.2885714285714286 0.3418803418803419 per, rfbE; perosamine synthetase [EC:2.6.1.102] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 157.0 297.0 275.0 4.0 0.922360248447205 E 134.0 188.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 322.0 0.4161490683229814 0.5838509316770186 0.792151744431042 0.983732339519941 0.8879420419754915 0.191580595088899 1 1 1 1 K13012 0.0 0.1168091168091168 wbqP; O-antigen biosynthesis protein WbqP 148.0 45.0 43.0 3.0 0.9375 M 0.0 48.0 3.0 0.895833333333333 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 48.0 0.0 1.0 0.0122702506174668 0.0519861767511603 0.0321282136843135 0.0397159261336935 0 0 0 0 K13013 0.0 0.037037037037037 wbqV; O-antigen biosynthesis protein WbqV 337.0 10.0 5.0 2.0 0.666666666666667 GM 0.0 15.0 1.0 1.0 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 15.0 0.0 1.0 0.0044502057251009 0.0222339957646213 0.013342100744861 0.0177837900395204 0 0 0 0 K13014 0.0057142857142857 0.0142450142450142 arnD; undecaprenyl phosphate-alpha-L-ara4FN deformylase [EC:3.5.1.-] path:map00520,path:map01100,path:map01503 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance 261.0 7.0 0.0 1.0 1.0 G 2.0 5.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 7.0 0.2857142857142857 0.7142857142857143 0.0461920168523251 0.0886367564064127 0.0674143866293689 0.0424447395540876 0 0 0 0 K13015 0.0657142857142857 0.396011396011396 wbpA; UDP-N-acetyl-D-glucosamine dehydrogenase [EC:1.1.1.136] path:map00520,path:map00541,path:map01100 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways 237.0 174.0 158.0 2.0 0.91578947368421 M 26.0 164.0 1.0 1.0 COG0677 UDP-N-acetyl-D-mannosaminuronate_dehydrogenase WecC 190.0 0.1368421052631579 0.8631578947368421 0.52125702113443 0.900758555417975 0.7110077882762025 0.379501534283545 0 1 0 1 K13016 0.0028571428571428 0.0541310541310541 wbpB; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 312.0 21.0 0.0 1.0 1.0 S 1.0 20.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 21.0 0.0476190476190476 0.9523809523809524 0.0187296993655732 0.0243368280746118 0.0215332637200925 0.0056071287090386 0 0 0 0 K13017 0.0028571428571428 0.0911680911680911 wbpE, wlbC; UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 315.0 30.0 28.0 3.0 0.909090909090909 E 1.0 32.0 2.0 0.939393939393939 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 33.0 0.0303030303030303 0.9696969696969696 0.0086401643800179 0.0634419706391859 0.0360410675096019 0.054801806259168 0 0 0 0 K13018 0.0257142857142857 0.1538461538461538 wbpD, wlbB; UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase [EC:2.3.1.201] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 132.0 66.0 60.0 3.0 0.904109589041096 S 9.0 63.0 2.0 0.904109589041096 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 72.0 0.125 0.875 0.462654296146893 0.216540881456816 0.3395975888018545 0.246113414690077 0 0 0 0 K13019 0.0171428571428571 0.1367521367521367 wbpI, wlbD; UDP-GlcNAc3NAcA epimerase [EC:5.1.3.23] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 288.0 44.0 29.0 2.0 0.745762711864407 M 7.0 52.0 1.0 1.0 COG0381 UDP-N-acetylglucosamine_2-epimerase WecB 59.0 0.1186440677966101 0.8813559322033898 0.654273133757575 0.489292058338447 0.571782596048011 0.164981075419128 0 1 0 1 K13020 0.0085714285714285 0.0883190883190883 wlbA, bplA; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 228.0 40.0 39.0 2.0 0.975609756097561 S 4.0 37.0 2.0 0.975609756097561 COG0673 Predicted_dehydrogenase MviM 41.0 0.0975609756097561 0.902439024390244 0.151808204537188 0.320794939375995 0.2363015719565915 0.168986734838807 0 0 0 0 K13021 0.02 0.0284900284900284 ttuB; MFS transporter, ACS family, tartrate transporter 72.0 20.0 17.0 2.0 0.869565217391304 G 9.0 14.0 2.0 0.565217391304348 COG2271 Sugar_phosphate_permease UhpC 23.0 0.391304347826087 0.6086956521739131 0.0234650253627981 0.044463722673024 0.033964374017911 0.0209986973102259 0 0 0 0 K13022 0.0 0.0028490028490028 CPZ; carboxypeptidase Z [EC:3.4.17.-] 322.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 KOG1934 1.0 0.0 1.0 0 0 0 0 K13023 0.0028571428571428 0.0 CPN2; carboxypeptidase N regulatory subunit 298.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG4886 Leucine-rich_repeat_(LRR)_protein LRR 1.0 1.0 0.0 0 0 0 0 K13028 0.0 0.0028490028490028 oxdA; aliphatic aldoxime dehydratase [EC:4.8.1.2] 347.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG5485 Predicted_ester_cyclase 1.0 0.0 1.0 0 0 0 0 K13037 0.0 0.0056980056980056 bacD; L-alanine-L-anticapsin ligase [EC:6.3.2.49] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 390.0 1.0 0.0 2.0 0.5 I 0.0 2.0 2.0 0.5 COG0439 Biotin_carboxylase AccC 2.0 0.0 1.0 0 0 0 0 K13038 0.6857142857142857 0.8490028490028491 coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5] path:map00770,path:map01100,path:map01240 Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of cofactors 177.0 560.0 526.0 2.0 0.942760942760943 H 258.0 335.0 2.0 0.944444444444444 COG0452 Phosphopantothenoylcysteine_synthetase/decarboxylase_CoaBC CoaBC 593.0 0.4350758853288364 0.5649241146711635 0.623901858226721 0.298019801677883 0.460960829952302 0.3258820565488379 0 1 0 1 K13039 0.1485714285714285 0.0113960113960113 comE; sulfopyruvate decarboxylase subunit beta [EC:4.1.1.79] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 130.0 50.0 44.0 3.0 0.87719298245614 G 53.0 4.0 2.0 0.87719298245614 COG4032 Sulfopyruvate_decarboxylase,_TPP-binding_subunit_(coenzyme_M_biosynthesis) 57.0 0.9298245614035088 0.0701754385964912 0.0585851788980735 0.159390904539715 0.1089880417188942 0.1008057256416415 0 0 0 0 K13040 0.0 0.0427350427350427 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3] path:map02020 Two-component system 116.0 31.0 28.0 2.0 0.911764705882353 T 0.0 34.0 10.0 0.205882352941176 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 34.0 0.0 1.0 0.127278314019714 0.0026517258687012 0.0649650199442076 0.1246265881510128 0 0 0 0 K13041 0.0 0.0284900284900284 ttrR; two-component system, LuxR family, response regulator TtrR path:map02020 Two-component system 197.0 9.0 8.0 2.0 0.9 K 0.0 10.0 1.0 1.0 COG4566 DNA-binding_response_regulator,_FixJ_family,_consists_of_REC_and_HTH_domains FixJ 10.0 0.0 1.0 0.0077487292360432 0.0170787264863202 0.0124137278611816 0.0093299972502769 0 0 0 0 K13042 0.0 0.0142450142450142 bsmB; dimethylglycine N-methyltransferase [EC:2.1.1.161] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 265.0 4.0 3.0 2.0 0.8 H 0.0 5.0 2.0 0.6 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 5.0 0.0 1.0 0.0592800163589719 0.161781365052995 0.1105306907059834 0.1025013486940231 0 0 0 0 K13043 0.0 0.0626780626780626 argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] 298.0 20.0 18.0 2.0 0.909090909090909 E 0.0 22.0 1.0 1.0 COG0078 Ornithine_carbamoyltransferase ArgF 22.0 0.0 1.0 0.0111694295735146 0.0272176825768128 0.0191935560751637 0.0160482530032982 0 0 0 0 K13048 0.0571428571428571 0.0 cps; carboxypeptidase Ss1 [EC:3.4.17.-] 335.0 24.0 20.0 2.0 0.857142857142857 E 28.0 0.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 28.0 1.0 0.0 0.769391911394187 0.957861198380028 0.8636265548871075 0.1884692869858411 0 0 1 1 K13049 0.0028571428571428 0.0712250712250712 PM20D1; carboxypeptidase PM20D1 [EC:3.4.17.-] 367.0 28.0 0.0 1.0 1.0 E 1.0 27.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 28.0 0.0357142857142857 0.9642857142857144 0.0403770985511443 0.102402212884093 0.0713896557176186 0.0620251143329487 0 0 0 0 K13051 0.2857142857142857 0.2478632478632478 ASRGL1, iaaA; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5] path:map00250,path:map00460,path:map01100,path:map01110 Alanine, aspartate and glutamate metabolism,Cyanoamino acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 164.0 213.0 210.0 2.0 0.986111111111111 E 110.0 107.0 3.0 0.981566820276498 COG1446 Isoaspartyl_peptidase_or_L-asparaginase,_Ntn-hydrolase_superfamily IaaA 217.0 0.5069124423963134 0.4930875576036866 0.002648889598818 0.971212061740819 0.4869304756698185 0.9685631721420008 0 0 0 0 K13052 0.0 0.245014245014245 divIC, divA; cell division protein DivIC 33.0 86.0 82.0 2.0 0.955555555555556 D 0.0 90.0 3.0 0.955555555555556 COG2919 Cell_division_protein_FtsB FtsB 90.0 0.0 1.0 0.330737152348113 0.0620691550272015 0.1964031536876572 0.2686679973209115 0 0 0 0 K13053 0.0 0.0398860398860398 sulA; cell division inhibitor SulA 124.0 8.0 1.0 2.0 0.533333333333333 D 0.0 15.0 4.0 0.466666666666667 COG4544 Uncharacterized_conserved_protein 15.0 0.0 1.0 0.013018597534565 0.0161515646106027 0.0145850810725838 0.0031329670760377 0 0 0 0 K13057 0.1542857142857142 0.1396011396011396 treT; trehalose synthase [EC:2.4.1.245] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 268.0 97.0 90.0 4.0 0.889908256880734 M 56.0 53.0 2.0 0.935779816513762 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 109.0 0.5137614678899083 0.4862385321100917 0.493309657154735 0.947862867893012 0.7205862625238735 0.454553210738277 0 0 0 0 K13058 0.0 0.0284900284900284 mfpsA; mannosylfructose-phosphate synthase [EC:2.4.1.246] 427.0 9.0 8.0 2.0 0.9 M 0.0 10.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 10.0 0.0 1.0 0.0240783781544945 0.0480862199205831 0.0360822990375388 0.0240078417660886 0 0 0 0 K13059 0.0 0.0085470085470085 nahK, lnpB; N-acetylhexosamine 1-kinase [EC:2.7.1.162] 316.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG2334 Ser/Thr_protein_kinase_RdoA_involved_in_Cpx_stress_response,_MazF_antagonist SrkA 3.0 0.0 1.0 0 0 0 0 K13060 0.0 0.0085470085470085 lasI; acyl homoserine lactone synthase [EC:2.3.1.184] path:map00270,path:map01100,path:map02024,path:map02025 Cysteine and methionine metabolism,Metabolic pathways,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 179.0 2.0 1.0 2.0 0.666666666666667 H 0.0 3.0 1.0 1.0 COG3916 N-acyl-homoserine_lactone_synthase_LasI_(autoinducer_biosynthesis) LasI 3.0 0.0 1.0 0 0 0 0 K13061 0.0 0.017094017094017 rhlI, phzI, solI, cepI, tofI; acyl homoserine lactone synthase [EC:2.3.1.184] path:map00270,path:map01100,path:map02020,path:map02024,path:map02025 Cysteine and methionine metabolism,Metabolic pathways,Two-component system,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 175.0 3.0 0.0 2.0 0.5 H 0.0 6.0 1.0 1.0 COG3916 N-acyl-homoserine_lactone_synthase_LasI_(autoinducer_biosynthesis) LasI 6.0 0.0 1.0 0.0399070392745011 0.105051692283336 0.0724793657789185 0.0651446530088349 0 0 0 0 K13062 0.0 0.0028490028490028 ainS, luxM; acyl homoserine lactone synthase [EC:2.3.1.184] path:map00270,path:map01100,path:map02024 Cysteine and methionine metabolism,Metabolic pathways,Quorum sensing 355.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2AVXK 1.0 0.0 1.0 0 0 0 0 K13063 0.0028571428571428 0.0199430199430199 phzE; 2-amino-4-deoxychorismate synthase [EC:2.6.1.86] path:map00405,path:map01100,path:map01110,path:map02024 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 601.0 10.0 0.0 1.0 1.0 EH 1.0 9.0 1.0 1.0 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 10.0 0.1 0.9 0.0075337898935309 0.0326471859343915 0.0200904879139612 0.0251133960408605 0 0 0 0 K13065 0.0 0.0056980056980056 E2.3.1.133, HCT; shikimate O-hydroxycinnamoyltransferase [EC:2.3.1.133] path:map00940,path:map00941,path:map00945,path:map01100,path:map01110 Phenylpropanoid biosynthesis,Flavonoid biosynthesis,Stilbenoid, diarylheptanoid and gingerol biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 88.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K13069 0.0 0.0769230769230769 E2.7.7.65; diguanylate cyclase [EC:2.7.7.65] 110.0 38.0 0.0 1.0 1.0 T 0.0 38.0 2.0 0.973684210526316 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 38.0 0.0 1.0 0.0041640930513874 0.0109054003217174 0.0075347466865524 0.00674130727033 0 0 0 0 K13071 0.0 0.0113960113960113 PAO, ACD1; pheophorbide a oxygenase [EC:1.14.15.17] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 442.0 5.0 0.0 1.0 1.0 P 0.0 5.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 5.0 0.0 1.0 1.5715740816032e-05 7.27973393094581e-07 8.22185710456329e-06 1.498776742293742e-05 0 0 0 0 K13074 0.0 0.0056980056980056 CYP158A2; biflaviolin synthase [EC:1.14.19.69] 369.0 1.0 0.0 2.0 0.5 C 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K13075 0.0942857142857142 0.074074074074074 ahlD, aiiA, attM, blcC; N-acyl homoserine lactone hydrolase [EC:3.1.1.81] path:map02024 Quorum sensing 119.0 56.0 49.0 3.0 0.823529411764706 S 40.0 28.0 1.0 1.0 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 68.0 0.5882352941176471 0.4117647058823529 0.0015799721596396 0.768157598219809 0.3848687851897243 0.7665776260601694 0 0 0 0 K13086 0.0 0.0199430199430199 mfppA; mannosylfructose-6-phosphate phosphatase [EC:3.1.3.79] 233.0 3.0 0.0 3.0 0.375 S 0.0 7.0 2.0 0.875 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 7.0 0.0 1.0 0.043036263526625 0.100972575045892 0.0720044192862585 0.0579363115192669 0 0 0 0 K13091 0.0028571428571428 0.0 RBM23_39; RNA-binding protein 23/39 154.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 KOG0147 1.0 1.0 0.0 0 0 0 0 K13126 0.0 0.0028490028490028 PABPC; polyadenylate-binding protein path:map03015,path:map03018 mRNA surveillance pathway,RNA degradation 79.0 1.0 0.0 1.0 1.0 AJ 0.0 1.0 1.0 1.0 KOG0123 1.0 0.0 1.0 0 0 0 0 K13195 0.0028571428571428 0.0028490028490028 CIRBP; cold-inducible RNA-binding protein 80.0 2.0 0.0 1.0 1.0 A 1.0 1.0 1.0 1.0 KOG0118 2.0 0.5 0.5 0 0 0 0 K13210 0.0028571428571428 0.0 FUBP; far upstream element-binding protein 195.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 COG5176 1.0 1.0 0.0 0 0 0 0 K13238 0.0057142857142857 0.0028490028490028 ECI1, DCI; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8] path:map00071 Fatty acid degradation 156.0 2.0 1.0 2.0 0.666666666666667 I 2.0 1.0 2.0 0.666666666666667 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K13243 0.0028571428571428 0.0113960113960113 dos; c-di-GMP-specific phosphodiesterase [EC:3.1.4.52] 113.0 6.0 0.0 1.0 1.0 T 1.0 5.0 5.0 0.333333333333333 COG5001 Cyclic_di-GMP_metabolism_protein,_combines_GGDEF_and_EAL_domains_with_a_6TM_membrane_domain 6.0 0.1666666666666666 0.8333333333333334 0.0202366153608286 0.0503933296604109 0.0353149725106197 0.0301567142995823 0 0 0 0 K13244 0.0 0.0028490028490028 yahA; c-di-GMP-specific phosphodiesterase [EC:3.1.4.52] 348.0 1.0 0.0 2.0 0.5 K 0.0 2.0 1.0 1.0 COG2200 EAL_domain,_c-di-GMP-specific_phosphodiesterase_class_I_(or_its_enzymatically_inactive_variant) EAL 2.0 0.0 1.0 0 0 0 0 K13245 0.0 0.0227920227920227 pdeA; c-di-GMP-specific phosphodiesterase [EC:3.1.4.52] path:map04112 Cell cycle - Caulobacter 688.0 8.0 0.0 1.0 1.0 T 0.0 8.0 2.0 0.875 COG5001 Cyclic_di-GMP_metabolism_protein,_combines_GGDEF_and_EAL_domains_with_a_6TM_membrane_domain 8.0 0.0 1.0 0.0005286810070728 0.0011639409831197 0.0008463109950962 0.0006352599760469 0 0 0 0 K13246 0.0 0.0199430199430199 vieA; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 128.0 7.0 0.0 1.0 1.0 T 0.0 7.0 2.0 0.714285714285714 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 7.0 0.0 1.0 0.0305549949715398 0.0762602052566232 0.0534076001140815 0.0457052102850834 0 0 0 0 K13252 0.0542857142857142 0.0569800569800569 ptcA; putrescine carbamoyltransferase [EC:2.1.3.6] 260.0 43.0 0.0 1.0 1.0 E 19.0 24.0 1.0 1.0 COG0078 Ornithine_carbamoyltransferase ArgF 43.0 0.4418604651162791 0.5581395348837209 0.341891314465235 0.617042611035891 0.479466962750563 0.2751512965706559 0 0 0 0 K13254 0.0028571428571428 0.0 SPAST; spastin [EC:5.6.1.1] 396.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 1.0 1.0 0.0 0 0 0 0 K13255 0.0 0.0256410256410256 fhuF; ferric iron reductase protein FhuF 226.0 9.0 8.0 2.0 0.9 S 0.0 10.0 1.0 1.0 COG4114 Ferric_iron_reductase_protein_FhuF,_involved_in_iron_transport FhuF 10.0 0.0 1.0 0.0123585765507373 0.0372610418247398 0.0248098091877385 0.0249024652740025 0 0 0 0 K13256 0.0 0.0398860398860398 psiE; protein PsiE 112.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG3223 Phosphate_starvation-inducible_membrane_PsiE_(function_unknown) PsiE 15.0 0.0 1.0 0.0136799168384111 0.0469150954067251 0.0302975061225681 0.033235178568314 0 0 0 0 K13273 0.0 0.0028490028490028 PMVK; phosphomevalonate kinase [EC:2.7.4.2] path:map00900,path:map01100,path:map01110,path:map04146 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Peroxisome 172.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 28S0B 1.0 0.0 1.0 0 0 0 0 K13274 0.0114285714285714 0.0455840455840455 wprA; cell wall-associated protease [EC:3.4.21.-] 208.0 22.0 19.0 2.0 0.88 O 5.0 20.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 25.0 0.2 0.8 0.093226704121196 0.447524838997501 0.2703757715593485 0.354298134876305 0 0 0 0 K13275 0.02 0.0199430199430199 isp; major intracellular serine protease [EC:3.4.21.-] 238.0 13.0 12.0 3.0 0.866666666666667 O 7.0 8.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 15.0 0.4666666666666667 0.5333333333333333 0.0649535981386575 0.181552499393653 0.1232530487661552 0.1165989012549955 0 0 0 0 K13276 0.0657142857142857 0.0997150997150997 bpr; bacillopeptidase F [EC:3.4.21.-] 93.0 30.0 0.0 6.0 0.36144578313253 M 25.0 57.0 6.0 0.72289156626506 COG1404 Serine_protease,_subtilisin_family AprE 82.0 0.3048780487804878 0.6951219512195121 0.253381576096635 0.469095239434842 0.3612384077657384 0.215713663338207 0 0 0 0 K13277 0.0285714285714285 0.0769230769230769 epr; minor extracellular protease Epr [EC:3.4.21.-] 55.0 29.0 20.0 7.0 0.58 O 10.0 40.0 11.0 0.56 COG1404 Serine_protease,_subtilisin_family AprE 50.0 0.2 0.8 0.0834572069139972 0.152483025500924 0.1179701162074605 0.0690258185869267 0 0 0 0 K13280 0.7742857142857142 0.094017094017094 SEC11, sipW; signal peptidase I [EC:3.4.21.89] path:map03060 Protein export 5.0 498.0 495.0 3.0 0.990059642147117 U 447.0 47.0 4.0 0.978131212723658 COG0681 Signal_peptidase_I LepB 494.0 0.9048582995951416 0.0951417004048583 0.348311022964522 0.76581355978352 0.557062291374021 0.4175025368189979 0 0 0 0 K13281 0.0457142857142857 0.0626780626780626 uvsE, UVE1; UV DNA damage endonuclease [EC:3.-.-.-] 227.0 41.0 0.0 1.0 1.0 L 18.0 23.0 2.0 0.975609756097561 COG4294 UV_DNA_damage_repair_endonuclease Uve 41.0 0.4390243902439024 0.5609756097560976 0.143273948450412 0.991874462387143 0.5675742054187776 0.8486005139367311 0 0 0 0 K13282 0.0114285714285714 0.131054131054131 cphB; cyanophycinase [EC:3.4.15.6] 162.0 45.0 30.0 3.0 0.737704918032787 PQ 4.0 57.0 1.0 1.0 COG4242 Cyanophycinase_and_related_exopeptidases CphB 61.0 0.0655737704918032 0.9344262295081968 0.109585084335555 0.748501765887768 0.4290434251116615 0.6389166815522129 0 0 0 0 K13283 0.0228571428571428 0.094017094017094 fieF; ferrous-iron efflux pump FieF 255.0 40.0 39.0 2.0 0.975609756097561 P 8.0 33.0 1.0 1.0 COG0053 Divalent_metal_cation_(Fe/Co/Zn/Cd)_efflux_pump FieF 41.0 0.1951219512195122 0.8048780487804879 0.0089935657809408 0.173570961597189 0.0912822636890648 0.1645773958162482 0 0 0 0 K13285 0.0 0.0056980056980056 sipB, ipaB, bipB; invasin B path:map05100,path:map05131,path:map05132 Bacterial invasion of epithelial cells,Shigellosis,Salmonella infection 333.0 3.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 28N7Q 3.0 0.0 1.0 0 0 0 0 K13287 0.0 0.0028490028490028 sipD, ipaD, bipD; invasin D path:map05100,path:map05131 Bacterial invasion of epithelial cells,Shigellosis 316.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2C6J3 2.0 0.0 1.0 0 0 0 0 K13288 0.04 0.2051282051282051 orn, REX2, REXO2; oligoribonuclease [EC:3.1.-.-] path:map03008 Ribosome biogenesis in eukaryotes 155.0 59.0 31.0 2.0 0.67816091954023 L 14.0 73.0 2.0 0.942528735632184 COG1949 Oligoribonuclease_(3'-5'_exoribonuclease) Orn 87.0 0.160919540229885 0.8390804597701149 0.0075008487781335 0.0140999146453983 0.0108003817117659 0.0065990658672648 0 0 0 0 K13289 0.0 0.0028490028490028 CTSA, CPY; cathepsin A (carboxypeptidase C) [EC:3.4.16.5] path:map04142,path:map04614 Lysosome,Renin-angiotensin system 481.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG2939 Carboxypeptidase_C_(cathepsin_A) Kex1 1.0 0.0 1.0 0 0 0 0 K13291 0.0028571428571428 0.0 TUT; terminal uridylyltransferase [EC:2.7.7.52] 690.0 1.0 0.0 1.0 1.0 D 1.0 0.0 1.0 1.0 COG5260 1.0 1.0 0.0 0 0 0 0 K13292 0.0885714285714285 0.7635327635327636 lgt, umpA; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] 72.0 353.0 347.0 2.0 0.983286908077994 M 33.0 327.0 3.0 0.966666666666667 COG0682 Prolipoprotein_diacylglyceryltransferase Lgt 360.0 0.0916666666666666 0.9083333333333332 0.407155156446093 0.660640139207715 0.533897647826904 0.253484982761622 0 0 0 0 K13293 0.0057142857142857 0.0028490028490028 PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] path:map00230,path:map01100,path:map04024,path:map04928,path:map05032 Purine metabolism,Metabolic pathways,cAMP signaling pathway,Parathyroid hormone synthesis, secretion and action,Morphine addiction 108.0 2.0 1.0 2.0 0.666666666666667 T 2.0 1.0 2.0 0.666666666666667 KOG1056 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K13300 0.0 0.0284900284900284 cccA; cytochrome c550 95.0 16.0 0.0 1.0 1.0 C 0.0 16.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 16.0 0.0 1.0 0.0040686597631304 0.0081192080083912 0.0060939338857608 0.0040505482452608 0 0 0 0 K13301 0.0 0.0085470085470085 secM; secretion monitor path:map03060,path:map03070 Protein export,Bacterial secretion system 131.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 2ATX7 3.0 0.0 1.0 0 0 0 0 K13307 0.0 0.0085470085470085 tylMI; dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.235] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 154.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.0 1.0 0 0 0 0 K13308 0.0057142857142857 0.0142450142450142 desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 359.0 7.0 0.0 1.0 1.0 E 2.0 5.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 7.0 0.2857142857142857 0.7142857142857143 0.0956549467000447 0.281461282821687 0.1885581147608658 0.1858063361216422 0 0 0 0 K13309 0.0 0.0028490028490028 desII, eryCV; dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase [EC:4.3.1.30] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 284.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 1.0 0.0 1.0 0 0 0 0 K13310 0.0028571428571428 0.0085470085470085 desV, eryCI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [EC:2.6.1.106] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 351.0 4.0 0.0 1.0 1.0 E 1.0 3.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 4.0 0.25 0.75 0.10818891718992 0.264771561161423 0.1864802391756715 0.1565826439715029 0 0 0 0 K13311 0.0114285714285714 0.0113960113960113 desVI, eryCVI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.234] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 224.0 8.0 0.0 1.0 1.0 Q 4.0 4.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 8.0 0.5 0.5 0.0140999288768444 0.280283638851797 0.1471917838643207 0.2661837099749526 0 0 0 0 K13313 0.0 0.0028490028490028 tylD, gerKI, mydI; dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase [EC:1.1.1.364] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 311.0 1.0 0.0 1.0 1.0 GM 0.0 1.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 1.0 0.0 1.0 0 0 0 0 K13315 0.0 0.0227920227920227 eryBII, tylCII, tylC1, calS12, atmS12; NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase [EC:1.1.1.-] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 319.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 8.0 0.0 1.0 0.0301279647022971 0.72359010502349 0.3768590348628935 0.6934621403211929 0 0 0 0 K13317 0.0 0.0056980056980056 eryBIII, tylCIII, tylC3; NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferase [EC:2.1.1.-] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 412.0 2.0 0.0 1.0 1.0 H 0.0 2.0 1.0 1.0 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 2.0 0.0 1.0 0 0 0 0 K13318 0.0028571428571428 0.0113960113960113 eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 315.0 4.0 2.0 2.0 0.666666666666667 M 1.0 5.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 6.0 0.1666666666666666 0.8333333333333334 6.04519384192093e-12 0.0736511120944269 0.036825556050236 0.0736511120883817 0 0 0 0 K13322 0.0028571428571428 0.0113960113960113 megDV; dTDP-4-keto-6-deoxyhexose 4-ketoreductase path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 315.0 4.0 2.0 2.0 0.666666666666667 M 1.0 5.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 6.0 0.1666666666666666 0.8333333333333334 6.07319971499774e-12 0.0734941768799829 0.036747088443028 0.0734941768739097 0 0 0 0 K13326 0.0114285714285714 0.0113960113960113 megDIII; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.- 2.1.1.234] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 224.0 8.0 0.0 1.0 1.0 Q 4.0 4.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 8.0 0.5 0.5 0.0141047499789694 0.274925404186738 0.1445150770828537 0.2608206542077686 0 0 0 0 K13327 0.0028571428571428 0.0199430199430199 spnN, oleW; dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase [EC:1.1.1.384] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 311.0 4.0 2.0 4.0 0.5 S 1.0 7.0 2.0 0.875 COG0673 Predicted_dehydrogenase MviM 8.0 0.125 0.875 0.0705098331421393 0.160837015446478 0.1156734242943086 0.0903271823043387 0 0 0 0 K13328 0.0085714285714285 0.0199430199430199 spnQ; dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase [EC:4.2.1.164] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 410.0 7.0 4.0 2.0 0.7 M 3.0 7.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 10.0 0.3 0.7 0.0511054696766169 0.134047901662989 0.0925766856698029 0.082942431986372 0 0 0 0 K13330 0.0 0.0085470085470085 spnS; dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase [EC:2.1.1.324] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 154.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.0 1.0 0 0 0 0 K13333 0.0 0.0028490028490028 PLB; lysophospholipase [EC:3.1.1.5] path:map00564 Glycerophospholipid metabolism 718.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 KOG1325 1.0 0.0 1.0 0 0 0 0 K13356 0.0 0.0085470085470085 FAR; alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] path:map00073,path:map04146,path:map04212 Cutin, suberine and wax biosynthesis,Peroxisome,Longevity regulating pathway - worm 250.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG3320 Thioester_reductase_domain_of_alpha_aminoadipate_reductase_Lys2_and_NRPSs Lys2b 3.0 0.0 1.0 0 0 0 0 K13372 0.0 0.0028490028490028 aauB; aralkylamine dehydrogenase heavy chain [EC:1.4.9.2] path:map00350,path:map00360,path:map00950,path:map01100,path:map01110 Tyrosine metabolism,Phenylalanine metabolism,Isoquinoline alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 976.0 3.0 0.0 1.0 1.0 CO 0.0 3.0 1.0 1.0 COG1858 Cytochrome_c_peroxidase MauG 3.0 0.0 1.0 0 0 0 0 K13378 0.3171428571428571 0.1737891737891738 nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 282.0 237.0 0.0 1.0 1.0 C 151.0 86.0 3.0 0.90295358649789 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 237.0 0.6371308016877637 0.3628691983122363 0.180790297118193 0.971606313099032 0.5761983051086125 0.7908160159808391 0 0 0 0 K13379 0.0028571428571428 0.0 RGP, UTM; reversibly glycosylated polypeptide / UDP-arabinopyranose mutase [EC:2.4.1.- 5.4.99.30] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 331.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 arCOG06245 1.0 1.0 0.0 0 0 0 0 K13380 0.0028571428571428 0.0256410256410256 nuoBCD; NADH-quinone oxidoreductase subunit B/C/D [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 362.0 10.0 0.0 1.0 1.0 C 1.0 9.0 2.0 0.7 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 10.0 0.1 0.9 0.851202642569475 0.864356562654727 0.857779602612101 0.013153920085252 0 0 1 1 K13381 0.0028571428571428 0.0256410256410256 chiA; bifunctional chitinase/lysozyme [EC:3.2.1.14 3.2.1.17] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 214.0 25.0 22.0 2.0 0.892857142857143 S 2.0 26.0 3.0 0.857142857142857 COG3979 Chitodextrinase 28.0 0.0714285714285714 0.9285714285714286 1.50822145855599e-12 0.0289889040298213 0.0144944520156647 0.028988904028313 0 0 0 0 K13408 0.0 0.0427350427350427 cvaA, mchE, raxA; membrane fusion protein path:map04626 Plant-pathogen interaction 195.0 12.0 8.0 2.0 0.75 M 0.0 16.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 16.0 0.0 1.0 0.0655189434078612 0.0888574032434066 0.0771881733256339 0.0233384598355454 0 0 0 0 K13409 0.0028571428571428 0.0455840455840455 cvaB, mchF, raxB; ATP-binding cassette, subfamily B, bacterial CvaB/MchF/RaxB path:map02010,path:map04626 ABC transporters,Plant-pathogen interaction 318.0 14.0 0.0 1.0 1.0 V 1.0 16.0 3.0 0.823529411764706 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 17.0 0.0588235294117647 0.9411764705882352 0.0496379475805576 0.140861668415065 0.0952498079978113 0.0912237208345074 0 0 0 0 K13412 0.0028571428571428 0.0 CPK; calcium-dependent protein kinase [EC:2.7.11.1] path:map04626,path:map05145 Plant-pathogen interaction,Toxoplasmosis 308.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 KOG0032 1.0 1.0 0.0 0 0 0 0 K13419 0.0 0.0113960113960113 pknK; serine/threonine-protein kinase PknK [EC:2.7.11.1] 25.0 6.0 4.0 2.0 0.75 KLT 0.0 8.0 3.0 0.75 COG0515 Serine/threonine_protein_kinase SPS1 8.0 0.0 1.0 0 0 0 0 K13421 0.1 0.1595441595441595 UMPS; uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] path:map00240,path:map00983,path:map01100,path:map01240 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Biosynthesis of cofactors 67.0 101.0 0.0 1.0 1.0 F 37.0 56.0 2.0 0.594059405940594 COG0461 Orotate_phosphoribosyltransferase PyrE 93.0 0.3978494623655914 0.6021505376344086 0.0162398636540578 0.446761655115515 0.2315007593847864 0.4305217914614572 0 0 0 0 K13443 0.0 0.0028490028490028 NPC2; Niemann-Pick C2 protein path:map04142,path:map04979 Lysosome,Cholesterol metabolism 161.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG4063 1.0 0.0 1.0 0 0 0 0 K13444 0.0 0.0227920227920227 SUMF1, FGE; formylglycine-generating enzyme [EC:1.8.3.7] path:map04142 Lysosome 210.0 8.0 6.0 2.0 0.8 S 0.0 10.0 1.0 1.0 COG1262 Formylglycine-generating_enzyme,_required_for_sulfatase_activity,_contains_SUMF1/FGE_domain YfmG 10.0 0.0 1.0 0.0125021988088461 0.0276524819861839 0.020077340397515 0.0151502831773378 0 0 0 0 K13448 0.0028571428571428 0.0 CML; calcium-binding protein CML path:map04626 Plant-pathogen interaction 153.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG5126 Ca2+-binding_protein,_EF-hand_superfamily FRQ1 1.0 1.0 0.0 0 0 0 0 K13450 0.0 0.0028490028490028 ospF, mkaD, spvC; phosphothreonine lyase [EC:4.2.3.-] path:map04626,path:map05131,path:map05132 Plant-pathogen interaction,Shigellosis,Salmonella infection 243.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2A0VH 1.0 0.0 1.0 0 0 0 0 K13455 0.0 0.0028490028490028 avrXccC, avrB; avirulence protein path:map04626 Plant-pathogen interaction 265.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 2EPA3 6.0 0.0 1.0 6.0367299299497e-13 8.82560144452822e-18 3.0184090929820733e-13 6.036641673935254e-13 0 0 0 0 K13472 0.0028571428571428 0.0028490028490028 raxST; sulfotransferase path:map04626 Plant-pathogen interaction 256.0 1.0 0.0 2.0 0.5 S 1.0 1.0 1.0 1.0 2C96H 2.0 0.5 0.5 0 0 0 0 K13479 0.0114285714285714 0.0683760683760683 ygeT, xdhB; xanthine dehydrogenase FAD-binding subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 244.0 28.0 27.0 2.0 0.96551724137931 C 4.0 25.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 29.0 0.1379310344827586 0.8620689655172413 0.699585784224775 0.746431579743727 0.723008681984251 0.0468457955189519 0 1 0 1 K13480 0.0 0.0085470085470085 ygeU, xdhC; xanthine dehydrogenase iron-sulfur-binding subunit path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 153.0 2.0 1.0 2.0 0.666666666666667 C 0.0 3.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 3.0 0.0 1.0 0 0 0 0 K13481 0.0057142857142857 0.1054131054131054 xdhA; xanthine dehydrogenase small subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 369.0 29.0 16.0 2.0 0.69047619047619 F 2.0 40.0 1.0 1.0 COG4630 Xanthine_dehydrogenase,_Fe-S_cluster_and_FAD-binding_subunit_XdhA XdhA 42.0 0.0476190476190476 0.9523809523809524 0.0569212315672847 0.562712480053206 0.3098168558102453 0.5057912484859213 0 0 0 0 K13482 0.0057142857142857 0.1025641025641025 xdhB; xanthine dehydrogenase large subunit [EC:1.17.1.4] path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 701.0 34.0 22.0 2.0 0.739130434782609 F 2.0 44.0 2.0 0.782608695652174 COG4631 Xanthine_dehydrogenase,_molybdopterin-binding_subunit_XdhB XdhB 46.0 0.0434782608695652 0.9565217391304348 0.0718969315655942 0.356249836006925 0.2140733837862596 0.2843529044413308 0 0 0 0 K13483 0.0114285714285714 0.1396011396011396 yagT; xanthine dehydrogenase YagT iron-sulfur-binding subunit path:map00230,path:map01100,path:map01120,path:map01232 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Nucleotide metabolism 136.0 77.0 76.0 2.0 0.987179487179487 C 4.0 74.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 78.0 0.0512820512820512 0.9487179487179488 0.825642547576733 0.187922904970956 0.5067827262738446 0.6377196426057771 1 1 1 1 K13485 0.0142857142857142 0.0455840455840455 PRHOXNB, URAD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 151.0 14.0 9.0 3.0 0.666666666666667 S 5.0 16.0 3.0 0.666666666666667 COG3195 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline_(OHCU)_decarboxylase_(uric_acid_degradation) PucL 21.0 0.238095238095238 0.7619047619047619 0.0276480768803755 0.0799392062095656 0.0537936415449705 0.0522911293291901 0 0 0 0 K13486 0.0 0.037037037037037 wspC; chemotaxis protein methyltransferase WspC path:map02020 Two-component system 200.0 12.0 11.0 2.0 0.923076923076923 NT 0.0 15.0 3.0 0.6 COG1352 Methylase_of_chemotaxis_methyl-accepting_proteins CheR 15.0 0.0 1.0 0.0377823312683604 0.0337915867480013 0.0357869590081808 0.0039907445203591 0 0 0 0 K13487 0.0057142857142857 0.0427350427350427 wspA; methyl-accepting chemotaxis protein WspA path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 236.0 29.0 26.0 2.0 0.90625 NT 2.0 30.0 1.0 1.0 COG0840 Methyl-accepting_chemotaxis_protein_(MCP) Tar 32.0 0.0625 0.9375 0.0023885328737033 0.0125198483973156 0.0074541906355094 0.0101313155236123 0 0 0 0 K13488 0.0 0.0227920227920227 wspB; chemotaxis-related protein WspB path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 86.0 9.0 0.0 1.0 1.0 NT 0.0 9.0 1.0 1.0 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 9.0 0.0 1.0 0.0150387303569777 0.025645041162075 0.0203418857595263 0.0106063108050973 0 0 0 0 K13489 0.0 0.0199430199430199 wspD; chemotaxis-related protein WspD path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 196.0 8.0 0.0 1.0 1.0 NT 0.0 8.0 1.0 1.0 COG0835 Chemotaxis_signal_transduction_protein_CheW CheW 8.0 0.0 1.0 0.0122537536601213 0.0204825503904651 0.0163681520252932 0.0082287967303438 0 0 0 0 K13490 0.0028571428571428 0.0484330484330484 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 424.0 20.0 19.0 2.0 0.952380952380952 T 1.0 20.0 2.0 0.952380952380952 COG0643 Chemotaxis_protein_histidine_kinase_CheA CheA 21.0 0.0476190476190476 0.9523809523809524 0.0056875018818254 0.0259538199124735 0.0158206608971494 0.0202663180306481 0 0 0 0 K13491 0.0028571428571428 0.017094017094017 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 337.0 7.0 0.0 1.0 1.0 NT 1.0 6.0 1.0 1.0 COG2201 Chemotaxis_response_regulator_CheB,_contains_REC_and_protein-glutamate_methylesterase_domains CheB 7.0 0.1428571428571428 0.8571428571428571 0.0337643158179477 0.0681411235066428 0.0509527196622952 0.034376807688695 0 0 0 0 K13497 0.1971428571428571 0.4159544159544159 trpGD; anthranilate synthase/phosphoribosyltransferase [EC:4.1.3.27 2.4.2.18] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 264.0 141.0 68.0 3.0 0.597457627118644 E 70.0 157.0 3.0 0.826271186440678 COG0547 Anthranilate_phosphoribosyltransferase,_glycosyltransferase_domain TrpD 227.0 0.3083700440528634 0.6916299559471366 0.909351680616684 0.811071571146306 0.860211625881495 0.098280109470378 1 1 1 1 K13498 0.0114285714285714 0.2165242165242165 trpCF; indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.1.48 5.3.1.24] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 205.0 88.0 0.0 1.0 1.0 E 4.0 79.0 2.0 0.920454545454545 COG0134 Indole-3-glycerol_phosphate_synthase TrpC 83.0 0.0481927710843373 0.9518072289156626 0.0856281418118884 0.0538387973896831 0.0697334696007857 0.0317893444222052 0 0 0 0 K13500 0.0057142857142857 0.0313390313390313 fcbD; chondroitin synthase [EC:2.4.1.175 2.4.1.226] path:map00532,path:map01100 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,Metabolic pathways 178.0 7.0 1.0 2.0 0.538461538461538 M 2.0 11.0 2.0 0.615384615384615 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 13.0 0.1538461538461538 0.8461538461538461 0.794026987314594 0.237256674393407 0.5156418308540005 0.556770312921187 0 0 1 1 K13503 0.0371428571428571 0.188034188034188 trpEG; anthranilate synthase [EC:4.1.3.27] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 295.0 53.0 34.0 3.0 0.63855421686747 EH 14.0 69.0 2.0 0.951807228915663 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 83.0 0.1686746987951807 0.8313253012048193 0.0100557028368381 0.0730963997056623 0.0415760512712502 0.0630406968688242 0 0 0 0 K13507 0.0142857142857142 0.0 GAT; glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42] path:map00561,path:map00564,path:map01100,path:map01110 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 484.0 5.0 0.0 1.0 1.0 I 5.0 0.0 1.0 1.0 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 5.0 1.0 0.0 0.0002375774056245 0.0009752049970705 0.0006063912013474 0.000737627591446 0 0 0 0 K13509 0.0028571428571428 0.0 AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51] path:map00561,path:map00564,path:map01100,path:map01110,path:map04072,path:map04975 Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Phospholipase D signaling pathway,Fat digestion and absorption 245.0 1.0 0.0 1.0 1.0 I 1.0 0.0 1.0 1.0 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 1.0 1.0 0.0 0 0 0 0 K13520 0.0 0.0113960113960113 icsP, sopA; outer membrane protease [EC:3.4.23.-] path:map05131 Shigellosis 298.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG4571 Outer_membrane_protease OmpT 6.0 0.0 1.0 0.0164413725004171 0.0286426867822052 0.0225420296413111 0.0122013142817881 0 0 0 0 K13522 0.0085714285714285 0.037037037037037 K13522, nadM; bifunctional NMN adenylyltransferase/nudix hydrolase [EC:2.7.7.1 3.6.1.-] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 90.0 9.0 3.0 3.0 0.529411764705882 FH 3.0 14.0 2.0 0.882352941176471 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 17.0 0.1764705882352941 0.8235294117647058 0.18759811751449 0.301092785360718 0.244345451437604 0.113494667846228 0 0 0 0 K13524 0.0057142857142857 0.0113960113960113 ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] path:map00250,path:map00280,path:map00410,path:map00640,path:map00650,path:map01100,path:map01120,path:map04727 Alanine, aspartate and glutamate metabolism,Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Propanoate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,GABAergic synapse 437.0 5.0 4.0 2.0 0.833333333333333 E 2.0 4.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 6.0 0.3333333333333333 0.6666666666666666 0.019131602276527 5.66952312800145e-08 0.0095658294858791 0.0191315455812957 0 0 0 0 K13525 0.9542857142857144 0.0968660968660968 VCP, CDC48; transitional endoplasmic reticulum ATPase path:map04141,path:map05014,path:map05022,path:map05134 Protein processing in endoplasmic reticulum,Amyotrophic lateral sclerosis,Pathways of neurodegeneration - multiple diseases,Legionellosis 347.0 668.0 584.0 3.0 0.885941644562334 O 715.0 39.0 6.0 0.957559681697613 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 754.0 0.9482758620689656 0.0517241379310344 0.870695265264179 0.7338821232854 0.8022886942747895 0.1368131419787789 1 1 1 1 K13527 0.0085714285714285 0.1054131054131054 mpa; proteasome-associated ATPase path:map03050 Proteasome 464.0 43.0 0.0 1.0 1.0 O 3.0 42.0 3.0 0.911111111111111 COG1222 ATP-dependent_26S_proteasome_regulatory_subunit RPT1 45.0 0.0666666666666666 0.9333333333333332 0.0300891993416515 0.156555083698407 0.0933221415200292 0.1264658843567555 0 0 0 0 K13529 0.0 0.0 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21] path:map03410 Base excision repair 54.0 34.0 4.0 0.666666666666667 K 0.0 0.0 5.0 0.740740740740741 COG0122 3-methyladenine_DNA_glycosylase/8-oxoguanine_DNA_glycosylase AlkA 0.0 0 0 0 0 K13530 0.0085714285714285 0.0512820512820512 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-] 139.0 23.0 0.0 1.0 1.0 K 3.0 20.0 3.0 0.695652173913044 COG2169 Methylphosphotriester-DNA--protein-cysteine_methyltransferase_(N-terminal_fragment_of_Ada),_contains_Zn-binding_and_two_AraC-type_DNA-binding_domains AdaA 23.0 0.1304347826086956 0.8695652173913043 0.051609225753113 0.435339085691422 0.2434741557222675 0.383729859938309 0 0 0 0 K13531 0.0257142857142857 0.0683760683760683 adaB; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 112.0 21.0 9.0 2.0 0.636363636363636 L 9.0 24.0 1.0 1.0 COG0350 DNA_repair_enzyme_Ada_(O6-methylguanine-DNA--protein-cysteine_methyltransferase) AdaB 33.0 0.2727272727272727 0.7272727272727273 0.925511356269381 0.788416535170615 0.856963945719998 0.1370948210987659 1 1 1 1 K13532 0.0 0.0056980056980056 kinD; two-component system, sporulation sensor kinase D [EC:2.7.13.3] path:map02020 Two-component system 227.0 2.0 0.0 1.0 1.0 T 0.0 2.0 2.0 0.5 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 2.0 0.0 1.0 0 0 0 0 K13533 0.0 0.0113960113960113 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3] path:map02020 Two-component system 273.0 4.0 0.0 1.0 1.0 T 0.0 4.0 2.0 0.75 COG3852 Signal_transduction_histidine_kinase_NtrB,_nitrogen_specific NtrB 4.0 0.0 1.0 0.0306847917663877 0.0668664377222739 0.0487756147443308 0.0361816459558861 0 0 0 0 K13537 0.0028571428571428 0.0 CPB; cysteine peptidase B [EC:3.4.22.-] path:map05140,path:map05143 Leishmaniasis,African trypanosomiasis 715.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K13538 0.0028571428571428 0.0 CPA; cysteine peptidase A [EC:3.4.22.-] 715.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K13540 0.0028571428571428 0.0598290598290598 cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 436.0 24.0 0.0 1.0 1.0 H 1.0 23.0 2.0 0.916666666666667 COG1010 Precorrin-3B_methylase CobJ 24.0 0.0416666666666666 0.9583333333333334 0.027663344808035 0.0812306527949452 0.05444699880149 0.0535673079869101 0 0 0 0 K13541 0.0 0.188034188034188 cbiGH-cobJ; cobalt-precorrin 5A hydrolase / cobalt-factor III methyltransferase / precorrin-3B C17-methyltransferase [EC:3.7.1.12 2.1.1.272 2.1.1.131] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 199.0 76.0 0.0 1.0 1.0 H 0.0 74.0 7.0 0.802631578947369 COG1010 Precorrin-3B_methylase CobJ 74.0 0.0 1.0 0.0173171071011093 0.705014772791659 0.3611659399463842 0.6876976656905497 0 0 0 0 K13542 0.0485714285714285 0.3789173789173789 cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 166.0 216.0 215.0 2.0 0.995391705069124 H 17.0 164.0 5.0 0.866359447004608 COG0007 Uroporphyrinogen-III_methylase_(siroheme_synthase) CysG 181.0 0.0939226519337016 0.9060773480662984 0.0851449852633073 0.912037880187811 0.4985914327255591 0.8268928949245037 0 0 0 0 K13543 0.0 0.0826210826210826 hemDX; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 116.0 30.0 0.0 1.0 1.0 H 0.0 30.0 3.0 0.433333333333333 COG2959 Proteobacterial_HemX_domain,_involved_in_2-ketogluconate_production_(unrelated_to_B._subtilis_HemX,_COG0755,_no_evidence_of_involvement_in_heme_biosynthesis) HemX 30.0 0.0 1.0 0.0313347022037922 0.172865802484013 0.1021002523439026 0.1415311002802208 0 0 0 0 K13566 0.1771428571428571 0.1994301994301994 NIT2, yafV; omega-amidase [EC:3.5.1.3] path:map00250,path:map01100 Alanine, aspartate and glutamate metabolism,Metabolic pathways 98.0 108.0 79.0 3.0 0.782608695652174 S 68.0 70.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 138.0 0.4927536231884058 0.5072463768115942 0.414900777238103 0.498985612018929 0.4569431946285159 0.084084834780826 0 0 0 0 K13570 0.0 0.0626780626780626 pup; prokaryotic ubiquitin-like protein Pup 58.0 13.0 3.0 2.0 0.565217391304348 O 0.0 23.0 1.0 1.0 2E9C2 23.0 0.0 1.0 0.0110630478124895 0.03578557667106 0.0234243122417747 0.0247225288585705 0 0 0 0 K13571 0.0057142857142857 0.0968660968660968 pafA; proteasome accessory factor A [EC:6.3.1.19] 398.0 21.0 12.0 5.0 0.5 O 2.0 40.0 2.0 0.761904761904762 COG0638 20S_proteasome,_alpha_and_beta_subunits PRE1 42.0 0.0476190476190476 0.9523809523809524 0.0113452894419777 0.0272297996016181 0.0192875445217979 0.0158845101596404 0 0 0 0 K13572 0.0028571428571428 0.1709401709401709 pafB; proteasome accessory factor B 128.0 71.0 0.0 1.0 1.0 K 1.0 70.0 1.0 1.0 COG2378 Predicted_DNA-binding_transcriptional_regulator_YobV,_contains_HTH_and_WYL_domains YobV 71.0 0.0140845070422535 0.9859154929577464 0.539591605709624 0.880839483429491 0.7102155445695575 0.3412478777198671 0 0 0 1 K13573 0.0 0.1253561253561253 pafC; proteasome accessory factor C 152.0 76.0 0.0 1.0 1.0 K 0.0 76.0 2.0 0.986842105263158 COG2378 Predicted_DNA-binding_transcriptional_regulator_YobV,_contains_HTH_and_WYL_domains YobV 76.0 0.0 1.0 0.0014595159794423 0.004102651914951 0.0027810839471966 0.0026431359355087 0 0 0 0 K13574 0.0028571428571428 0.0284900284900284 hcxB; hydroxycarboxylate dehydrogenase B [EC:1.1.1.237 1.1.1.-] path:map00350,path:map00360,path:map01100,path:map01110 Tyrosine metabolism,Phenylalanine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 312.0 28.0 0.0 1.0 1.0 C 1.0 27.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 28.0 0.0357142857142857 0.9642857142857144 2.1705563643800498e-12 3.3379741710390995e-12 2.754265267709575e-12 1.1674178066590501e-12 0 0 0 0 K13580 0.0 0.0028490028490028 K13580; magnesium chelatase subunit ChlD-like protein 195.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG1240 vWFA_(von_Willebrand_factor_type_A)_domain_of_Mg_and_Co_chelatases ChlD 1.0 0.0 1.0 0 0 0 0 K13581 0.0085714285714285 0.0911680911680911 ccrM; modification methylase [EC:2.1.1.72] path:map04112 Cell cycle - Caulobacter 341.0 33.0 31.0 2.0 0.942857142857143 L 3.0 32.0 1.0 1.0 COG2189 Adenine_specific_DNA_methylase_Mod Mod 35.0 0.0857142857142857 0.9142857142857144 0.102072256192649 0.186704879035645 0.144388567614147 0.084632622842996 0 0 0 0 K13582 0.0 0.1196581196581196 podJ; localization factor PodJL path:map04112 Cell cycle - Caulobacter 20.0 21.0 10.0 6.0 0.411764705882353 L 0.0 50.0 9.0 0.377358490566038 COG0497 DNA_repair_ATPase_RecN RecN 50.0 0.0 1.0 0.0497718041912373 0.158768274558851 0.1042700393750441 0.1089964703676137 0 0 0 0 K13583 0.0 0.0854700854700854 gcrA; GcrA cell cycle regulator path:map04112 Cell cycle - Caulobacter 94.0 33.0 0.0 1.0 1.0 S 0.0 33.0 1.0 1.0 COG5352 Uncharacterized_conserved_protein 33.0 0.0 1.0 0.0017515834201564 0.0051051001231822 0.0034283417716693 0.0033535167030258 0 0 0 0 K13584 0.0 0.0712250712250712 ctrA; two-component system, cell cycle response regulator CtrA path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 225.0 9.0 0.0 3.0 0.346153846153846 K 0.0 26.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 26.0 0.0 1.0 0.000528947378271 0.0016130600774897 0.0010710037278803 0.0010841126992186 0 0 0 0 K13586 0.0 0.0085470085470085 hfaB; holdfast attachment protein HfaB path:map04112 Cell cycle - Caulobacter 219.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1462 Curli_biogenesis_system_outer_membrane_secretion_channel_CsgG CsgG 3.0 0.0 1.0 0 0 0 0 K13587 0.0 0.0769230769230769 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3] path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 382.0 29.0 0.0 1.0 1.0 T 0.0 29.0 4.0 0.655172413793103 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 29.0 0.0 1.0 0.0023161176229138 0.0068211653122277 0.0045686414675707 0.0045050476893139 0 0 0 0 K13588 0.0 0.0569800569800569 chpT; histidine phosphotransferase ChpT path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 159.0 20.0 0.0 1.0 1.0 S 0.0 20.0 1.0 1.0 COG5385 Histidine_phosphotransfer_protein_ChpT,_HPt_domain HPt 20.0 0.0 1.0 7.304746387072901e-11 0.0023277675070302 0.0011638837900388 0.0023277674339827 0 0 0 0 K13589 0.0 0.0512820512820512 cpdR; two-component system, cell cycle response regulator CpdR path:map02020,path:map04112 Two-component system,Cell cycle - Caulobacter 117.0 18.0 17.0 2.0 0.947368421052632 T 0.0 19.0 3.0 0.736842105263158 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 19.0 0.0 1.0 0.0019947120675986 0.0865698807629092 0.0442822964152539 0.0845751686953105 0 0 0 0 K13590 0.0028571428571428 0.1452991452991453 dgcB; diguanylate cyclase [EC:2.7.7.65] path:map04112 Cell cycle - Caulobacter 82.0 70.0 69.0 2.0 0.985915492957746 T 1.0 70.0 5.0 0.929577464788732 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 71.0 0.0140845070422535 0.9859154929577464 0.004509503403571 0.0111247945404264 0.0078171489719987 0.0066152911368554 0 0 0 0 K13591 0.0 0.0028490028490028 popA; two-component system, cell cycle response regulator PopA path:map04112 Cell cycle - Caulobacter 227.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 1.0 0.0 1.0 0 0 0 0 K13592 0.0 0.0256410256410256 rcdA; regulator of CtrA degradation path:map04112 Cell cycle - Caulobacter 123.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 COG5317 Uncharacterized_conserved_protein,_DUF1465_domain 9.0 0.0 1.0 6.63117495716382e-06 1.76743940793812e-07 3.403959448978816e-06 6.454431016370008e-06 0 0 0 0 K13593 0.0 0.0313390313390313 tipF; cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF path:map04112 Cell cycle - Caulobacter 157.0 11.0 9.0 2.0 0.846153846153846 T 0.0 13.0 3.0 0.769230769230769 COG2200 EAL_domain,_c-di-GMP-specific_phosphodiesterase_class_I_(or_its_enzymatically_inactive_variant) EAL 13.0 0.0 1.0 0.0038220486077954 0.0100017032667453 0.0069118759372703 0.0061796546589498 0 0 0 0 K13598 0.0 0.2193732193732193 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3] path:map02020 Two-component system 359.0 79.0 78.0 2.0 0.9875 T 0.0 80.0 5.0 0.95 COG5000 Signal_transduction_histidine_kinase_NtrY_involved_in_nitrogen_fixation_and_metabolism_regulation NtrY 80.0 0.0 1.0 0.0011509635019818 0.0034320120102866 0.0022914877561342 0.0022810485083048 0 0 0 0 K13599 0.0 0.282051282051282 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX path:map02020 Two-component system 136.0 94.0 50.0 3.0 0.676258992805755 T 0.0 138.0 3.0 0.661870503597122 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 138.0 0.0 1.0 0.0018083742672176 0.016135681221039 0.0089720277441283 0.0143273069538213 0 0 0 0 K13601 0.0 0.0085470085470085 bchQ; bacteriochlorophyllide d C-8(2)-methyltransferase [EC:2.1.1.332] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 453.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 4.0 0.0 1.0 2.00271305778171e-21 9.990949204197181e-14 4.995474702234244e-14 9.990949003925877e-14 0 0 0 0 K13602 0.0 0.0085470085470085 bchR; bacteriochlorophyllide d C-12(1)-methyltransferase [EC:2.1.1.331] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 431.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 4.0 0.0 1.0 3.16952391153558e-11 4.2952023112962205e-09 2.163448775205788e-09 4.263507072180865e-09 0 0 0 0 K13603 0.0 0.0113960113960113 bchV; 3-vinyl bacteriochlorophyllide hydratase [EC:4.2.1.169] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 154.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 294R4 6.0 0.0 1.0 8.16421455829845e-07 2.24548915711099e-12 4.08211850659501e-07 8.164192103406879e-07 0 0 0 0 K13604 0.0 0.017094017094017 bchU; bacteriochlorophyllide d C-20 methyltransferase [EC:2.1.1.333] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 306.0 4.0 1.0 2.0 0.571428571428571 H 0.0 7.0 1.0 1.0 COG2813 16S_rRNA_G1207_methylase_RsmC RsmC 7.0 0.0 1.0 0.0318994894488252 0.089590244208734 0.0607448668287796 0.0576907547599088 0 0 0 0 K13605 0.0057142857142857 0.0113960113960113 bchK; bacteriochlorophyll c synthase [EC:2.5.1.-] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 285.0 6.0 0.0 1.0 1.0 H 2.0 4.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 6.0 0.3333333333333333 0.6666666666666666 0.0629119986012052 0.147617360854934 0.1052646797280695 0.0847053622537288 0 0 0 0 K13606 0.0057142857142857 0.0 NOL, NYC1; chlorophyll(ide) b reductase [EC:1.1.1.294] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 262.0 2.0 0.0 1.0 1.0 Q 2.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 1.0 0.0 0 0 0 0 K13607 0.0 0.0056980056980056 fldA; cinnamoyl-CoA:phenyllactate CoA-transferase [EC:2.8.3.17] path:map00960,path:map01110 Tropane, piperidine and pyridine alkaloid biosynthesis,Biosynthesis of secondary metabolites 406.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 2.0 0.0 1.0 0 0 0 0 K13609 0.0 0.0284900284900284 dpkA, lhpD; delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21] path:map00310,path:map00960,path:map01100 Lysine degradation,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways 326.0 10.0 0.0 1.0 1.0 C 0.0 10.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 10.0 0.0 1.0 0.0432063099554361 0.092407371113387 0.0678068405344115 0.0492010611579509 0 0 0 0 K13611 0.0028571428571428 0.0484330484330484 pksJ, baeJ; bacillaene biosynthesis, polyketide synthase / nonribosomal peptide synthetase PksJ/BaeJ 123.0 17.0 13.0 4.0 0.739130434782609 Q 1.0 22.0 6.0 0.391304347826087 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 23.0 0.0434782608695652 0.9565217391304348 0.0098422430873429 0.0194398676986315 0.0146410553929872 0.0095976246112885 0 0 0 0 K13612 0.0 0.0256410256410256 pksL, baeL; bacillaene polyketide synthase PksL/BaeL 42.0 5.0 2.0 4.0 0.5 Q 0.0 10.0 7.0 0.3 COG0300 Short-chain_dehydrogenase YqjQ 10.0 0.0 1.0 0.0041547793163857 0.0129342267203877 0.0085445030183867 0.008779447404002 0 0 0 0 K13613 0.0057142857142857 0.0313390313390313 pksM, baeM; bacillaene polyketide synthase PksM/BaeM 55.0 8.0 6.0 6.0 0.571428571428571 Q 2.0 12.0 9.0 0.285714285714286 COG0500 SAM-dependent_methyltransferase SmtA 14.0 0.1428571428571428 0.8571428571428571 0.0054487581422004 0.0130660508886998 0.0092574045154501 0.0076172927464994 0 0 0 0 K13614 0.0 0.0427350427350427 pksN, baeN; bacillaene biosynthesis, polyketide synthase / nonribosomal peptide synthetase PksN/BaeN 17.0 15.0 11.0 6.0 0.625 Q 0.0 22.0 9.0 0.25 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 22.0 0.0 1.0 1.34061180631131e-12 0.008938197104341 0.0044690985528408 0.0089381971030003 0 0 0 0 K13615 0.0 0.0056980056980056 pksR, baeR; bacillaene polyketide synthase PksR/BaeR 1083.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 2.0 0.5 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 2.0 0.0 1.0 0 0 0 0 K13617 0.0028571428571428 0.0 PPME1; protein phosphatase methylesterase 1 [EC:3.1.1.89] 98.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG4888 Transcription_elongation_factor_Elf1,_contains_Zn-ribbon_domain Elf1 1.0 1.0 0.0 0 0 0 0 K13620 0.0 0.0028490028490028 wcaD; putative colanic acid polymerase 405.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28KKV 1.0 0.0 1.0 0 0 0 0 K13622 0.0 0.0541310541310541 btaA; S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase path:map00564 Glycerophospholipid metabolism 267.0 18.0 15.0 2.0 0.857142857142857 I 0.0 21.0 2.0 0.857142857142857 COG5379 S-adenosylmethionine:diacylglycerol_3-amino-3-carboxypropyl_transferase BtaA 21.0 0.0 1.0 0.0045685180932526 0.0096364261761891 0.0071024721347208 0.0050679080829365 0 0 0 0 K13623 0.0 0.0341880341880341 btaB; S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase path:map00564 Glycerophospholipid metabolism 200.0 9.0 6.0 2.0 0.75 Q 0.0 12.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 12.0 0.0 1.0 0.003051544356089 0.0094422932014341 0.0062469187787615 0.006390748845345 0 0 0 0 K13625 0.0028571428571428 0.0 FTL; ferritin light chain path:map04216,path:map04217,path:map04978 Ferroptosis,Necroptosis,Mineral absorption 195.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG2039 Pyrrolidone-carboxylate_peptidase_(N-terminal_pyroglutamyl_peptidase) Pcp 1.0 1.0 0.0 0 0 0 0 K13626 0.0 0.2621082621082621 fliW; flagellar assembly factor FliW 67.0 67.0 50.0 4.0 0.644230769230769 S 0.0 104.0 2.0 0.855769230769231 COG1699 Flagellar_assembly_factor_FliW FliW 104.0 0.0 1.0 0.017286869976648 0.542972399687101 0.2801296348318745 0.525685529710453 0 0 0 0 K13628 0.2857142857142857 0.5299145299145299 iscA; iron-sulfur cluster assembly protein 46.0 317.0 251.0 3.0 0.821243523316062 S 114.0 272.0 2.0 0.994818652849741 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 386.0 0.2953367875647668 0.7046632124352331 0.000529824149948 0.136146890075938 0.068338357112943 0.13561706592599 0 0 0 0 K13629 0.0 0.0085470085470085 dsdX; D-serine transporter 437.0 2.0 1.0 2.0 0.666666666666667 EG 0.0 3.0 1.0 1.0 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 3.0 0.0 1.0 0 0 0 0 K13630 0.0 0.0028490028490028 marB; multiple antibiotic resistance protein MarB 72.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2E68Q 1.0 0.0 1.0 0 0 0 0 K13631 0.0 0.0085470085470085 soxS; AraC family transcriptional regulator, mar-sox-rob regulon activator 99.0 4.0 0.0 1.0 1.0 K 0.0 4.0 2.0 0.5 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 4.0 0.0 1.0 0.0063625409265408 3.31795703164686e-09 0.0031812721222489 0.0063625376085837 0 0 0 0 K13632 0.0 0.0056980056980056 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator path:map01503 Cationic antimicrobial peptide (CAMP) resistance 102.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG4977 Transcriptional_regulator_GlxA,_contains_an_amidase_domain_and_an_AraC-type_DNA-binding_HTH_domain GlxA 2.0 0.0 1.0 0 0 0 0 K13633 0.0 0.0341880341880341 ftrA; AraC family transcriptional regulator, transcriptional activator FtrA 314.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG4977 Transcriptional_regulator_GlxA,_contains_an_amidase_domain_and_an_AraC-type_DNA-binding_HTH_domain GlxA 14.0 0.0 1.0 0.0219501421964518 0.0290957368740404 0.0255229395352461 0.0071455946775885 0 0 0 0 K13634 0.0 0.0712250712250712 cysB; LysR family transcriptional regulator, cys regulon transcriptional activator 300.0 30.0 0.0 1.0 1.0 K 0.0 30.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 30.0 0.0 1.0 0.0018556550193608 0.0039448698187902 0.0029002624190755 0.0020892147994294 0 0 0 0 K13635 0.0 0.0256410256410256 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator 305.0 12.0 0.0 1.0 1.0 K 0.0 12.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 12.0 0.0 1.0 0.0051861736360441 0.0106459696164041 0.0079160716262241 0.00545979598036 0 0 0 0 K13636 0.0 0.0056980056980056 dsdC; LysR family transcriptional regulator, D-serine deaminase activator 304.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K13637 0.0 0.0142450142450142 uxuR; GntR family transcriptional regulator, uxu operon transcriptional repressor 214.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 5.0 0.0 1.0 0.0474920180284565 0.107384187533147 0.0774381027808017 0.0598921695046905 0 0 0 0 K13638 0.0 0.0484330484330484 zntR; MerR family transcriptional regulator, Zn(II)-responsive regulator of zntA 100.0 17.0 0.0 1.0 1.0 K 0.0 17.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 17.0 0.0 1.0 0.0254884730434598 0.0555454140639186 0.0405169435536892 0.0300569410204588 0 0 0 0 K13639 0.0 0.1424501424501424 soxR; MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR 107.0 61.0 0.0 1.0 1.0 K 0.0 61.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 61.0 0.0 1.0 0.0058307075702147 0.0152785515624737 0.0105546295663442 0.0094478439922589 0 0 0 0 K13640 0.0085714285714285 0.2421652421652421 hspR; MerR family transcriptional regulator, heat shock protein HspR 65.0 102.0 100.0 2.0 0.980769230769231 K 3.0 101.0 2.0 0.980769230769231 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 104.0 0.0288461538461538 0.971153846153846 0.0010836329806542 0.357788622634517 0.1794361278075856 0.3567049896538627 0 0 0 0 K13641 0.02 0.1452991452991453 iclR; IclR family transcriptional regulator, acetate operon repressor 173.0 102.0 0.0 1.0 1.0 K 7.0 95.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 102.0 0.0686274509803921 0.931372549019608 0.233555829462585 0.262965878764136 0.2482608541133605 0.029410049301551 0 0 0 0 K13642 0.0 0.017094017094017 ftrB; CRP/FNR family transcriptional regulator, transcriptional activator FtrB 231.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 6.0 0.0 1.0 0.010066919715387 0.0237882272239593 0.0169275734696731 0.0137213075085723 0 0 0 0 K13643 0.0028571428571428 0.2193732193732193 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor 103.0 85.0 0.0 1.0 1.0 K 1.0 84.0 1.0 1.0 COG1959 DNA-binding_transcriptional_regulator,_IscR_family IscR 85.0 0.0117647058823529 0.9882352941176472 0.977233376357873 0.644736227775421 0.810984802066647 0.332497148582452 0 0 1 1 K13645 0.0028571428571428 0.0 PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 249.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1971 1.0 1.0 0.0 0 0 0 0 K13646 0.0028571428571428 0.0 PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66] path:map00310,path:map00514,path:map01100 Lysine degradation,Other types of O-glycan biosynthesis,Metabolic pathways 249.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1971 1.0 1.0 0.0 0 0 0 0 K13647 0.0028571428571428 0.0 PLODN; procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 249.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1971 1.0 1.0 0.0 0 0 0 0 K13650 0.0 0.0028490028490028 mcbA; MqsR-controlled colanic acid and biofilm protein A 86.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DPRH 1.0 0.0 1.0 0 0 0 0 K13651 0.0 0.0256410256410256 mqsR; motility quorum-sensing regulator / GCU-specific mRNA interferase toxin 97.0 9.0 8.0 2.0 0.9 S 0.0 10.0 2.0 0.8 2D16E 10.0 0.0 1.0 0.0522546528265983 0.067996066434584 0.0601253596305911 0.0157414136079857 0 0 0 0 K13652 0.0342857142857142 0.1424501424501424 K13652; AraC family transcriptional regulator 21.0 80.0 73.0 3.0 0.898876404494382 K 13.0 79.0 4.0 0.670212765957447 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 92.0 0.1413043478260869 0.8586956521739131 0.0093431855466852 0.01530277244064 0.0123229789936625 0.0059595868939548 0 0 0 0 K13653 0.0171428571428571 0.1737891737891738 K13653; AraC family transcriptional regulator 20.0 100.0 0.0 1.0 1.0 K 7.0 90.0 4.0 0.71 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 97.0 0.0721649484536082 0.9278350515463918 0.0078874835610975 0.442612170516565 0.2252498270388312 0.4347246869554675 0 0 0 0 K13654 0.0 0.0028490028490028 mcbR; GntR family transcriptional regulator, colanic acid and biofilm gene transcriptional regulator 221.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1802 DNA-binding_transcriptional_regulator,_GntR_family GntR 1.0 0.0 1.0 0 0 0 0 K13655 0.0 0.0341880341880341 mqsA; HTH-type transcriptional regulator / antitoxin MqsA 127.0 15.0 0.0 1.0 1.0 K 0.0 15.0 2.0 0.8 COG2944 DNA-binding_transcriptional_regulator_YiaG,_XRE-type_HTH_domain YiaG 15.0 0.0 1.0 0.0206023560598822 0.0414778992054748 0.0310401276326785 0.0208755431455926 0 0 0 0 K13657 0.0028571428571428 0.0199430199430199 gumH, aceA; alpha-1,3-mannosyltransferase [EC:2.4.1.252] path:map00543 Exopolysaccharide biosynthesis 299.0 9.0 0.0 1.0 1.0 M 1.0 8.0 2.0 0.555555555555556 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 9.0 0.1111111111111111 0.8888888888888888 0.0599828984378658 0.105415695957781 0.0826992971978234 0.0454327975199152 0 0 0 0 K13658 0.0 0.0028490028490028 gumI; beta-1,4-mannosyltransferase [EC:2.4.1.251] path:map00543 Exopolysaccharide biosynthesis 316.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K13659 0.0 0.0142450142450142 gumK; 2-beta-glucuronyltransferase [EC:2.4.1.264] path:map00543 Exopolysaccharide biosynthesis 294.0 3.0 1.0 2.0 0.6 M 0.0 5.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 5.0 0.0 1.0 0.103314887459106 0.695920675163741 0.3996177813114235 0.592605787704635 0 0 0 0 K13660 0.0 0.017094017094017 gumM; beta-1,4-glucosyltransferase [EC:2.4.1.-] path:map00543 Exopolysaccharide biosynthesis 251.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG1922 UDP-N-acetyl-D-mannosaminuronic_acid_transferase,_WecB/TagA/CpsF_family WecG 6.0 0.0 1.0 0.0503625227152125 0.112435650033208 0.0813990863742102 0.0620731273179955 0 0 0 0 K13661 0.0 0.0227920227920227 gumC; GumC protein 650.0 9.0 8.0 2.0 0.9 D 0.0 10.0 1.0 1.0 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 10.0 0.0 1.0 0.0490423459677983 0.255871420120037 0.1524568830439176 0.2068290741522387 0 0 0 0 K13662 0.0 0.0028490028490028 gumE; putative polymerase 431.0 0.0 1.0 1.0 1.0 2BVF4 1.0 0.0 1.0 0 0 0 0 K13663 0.0 0.0056980056980056 gumF; acyltransferase [EC:2.3.1.-] path:map00543 Exopolysaccharide biosynthesis 85.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG3594 Fucose_4-O-acetylase_or_related_acetyltransferase NolL 2.0 0.0 1.0 0 0 0 0 K13664 0.0 0.0056980056980056 gumG; acyltransferase [EC:2.3.1.-] path:map00543 Exopolysaccharide biosynthesis 245.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG3594 Fucose_4-O-acetylase_or_related_acetyltransferase NolL 2.0 0.0 1.0 0 0 0 0 K13665 0.0 0.0056980056980056 gumL; pyruvyltransferase path:map00543 Exopolysaccharide biosynthesis 219.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG2327 Polysaccharide_pyruvyl_transferase_family_protein_WcaK_(colanic_acid_biosynthesis) WcaK 2.0 0.0 1.0 0 0 0 0 K13668 0.0428571428571428 0.1424501424501424 pimB; phosphatidyl-myo-inositol dimannoside synthase [EC:2.4.1.346] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 141.0 74.0 73.0 2.0 0.986666666666667 M 17.0 58.0 2.0 0.986666666666667 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 75.0 0.2266666666666666 0.7733333333333333 0.176615117553969 0.866420466986306 0.5215177922701375 0.6898053494323371 0 0 0 0 K13669 0.0028571428571428 0.0541310541310541 pimE; alpha-1,2-mannosyltransferase [EC:2.4.1.-] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 34.0 19.0 13.0 3.0 0.730769230769231 F 1.0 25.0 2.0 0.730769230769231 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 26.0 0.0384615384615384 0.9615384615384616 0.0237364720752792 0.071295530373214 0.0475160012242465 0.0475590582979347 0 0 0 0 K13671 0.0028571428571428 0.0455840455840455 K13671; alpha-1,2-mannosyltransferase [EC:2.4.1.-] path:map00571 Lipoarabinomannan (LAM) biosynthesis 270.0 22.0 16.0 3.0 0.733333333333333 S 1.0 29.0 3.0 0.8 COG5650 Uncharacterized_membrane_protein 30.0 0.0333333333333333 0.9666666666666668 0.0045163960322434 0.0905861328096625 0.0475512644209529 0.0860697367774191 0 0 0 0 K13677 0.0457142857142857 0.0455840455840455 dgs, bgsA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 184.0 33.0 0.0 1.0 1.0 M 17.0 16.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 33.0 0.5151515151515151 0.4848484848484848 0.977622407043433 0.897369338391894 0.9374958727176634 0.0802530686515389 1 1 1 1 K13678 0.0 0.0199430199430199 cpoA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-galactosyltransferase [EC:2.4.1.-] path:map00552 Teichoic acid biosynthesis 318.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 8.0 0.0 1.0 0.926276965281946 0.471645196982285 0.6989610811321155 0.454631768299661 0 0 1 1 K13679 0.0 0.0028490028490028 WAXY; granule-bound starch synthase [EC:2.4.1.242] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 526.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG0297 Glycogen_synthase GlgA 1.0 0.0 1.0 0 0 0 0 K13681 0.0028571428571428 0.0 FUT; xyloglucan fucosyltransferase [EC:2.4.1.-] 178.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0084 1.0 1.0 0.0 0 0 0 0 K13683 0.0 0.0284900284900284 wcaE; putative colanic acid biosynthesis glycosyltransferase WcaE [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 201.0 5.0 2.0 3.0 0.5 M 0.0 10.0 2.0 0.5 COG1216 Glycosyltransferase,_GT2_family WcaE 10.0 0.0 1.0 0.085544703010551 0.173768066423286 0.1296563847169184 0.0882233634127349 0 0 0 0 K13684 0.0 0.017094017094017 wcaC; putative colanic acid biosynthesis glycosyltransferase WcaC [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 363.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 7.0 0.0 1.0 7.653432670980289e-12 0.0955737356958771 0.0477868678517652 0.0955737356882236 0 0 0 0 K13686 0.0 0.0113960113960113 aftA; galactan 5-O-arabinofuranosyltransferase [EC:2.4.2.46] path:map00572,path:map01100 Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 598.0 3.0 2.0 2.0 0.75 S 0.0 5.0 2.0 0.8 28MYD 5.0 0.0 1.0 2.03488381120856e-05 3.03095782128224e-06 1.168989796668392e-05 1.7317880290803363e-05 0 0 0 0 K13687 0.0 0.0284900284900284 aftB; arabinofuranosyltransferase [EC:2.4.2.-] path:map00571,path:map00572 Lipoarabinomannan (LAM) biosynthesis,Arabinogalactan biosynthesis - Mycobacterium 329.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 15.0 0.0 1.0 0.0184401070249341 0.122197480430783 0.0703187937278585 0.1037573734058489 0 0 0 0 K13688 0.0057142857142857 0.0769230769230769 chvB, cgs, ndvB; cyclic beta-1,2-glucan synthetase [EC:2.4.1.-] 448.0 34.0 33.0 2.0 0.971428571428571 G 2.0 33.0 1.0 1.0 COG3459 Cellobiose_phosphorylase 35.0 0.0571428571428571 0.9428571428571428 0.0235602470732049 0.0612098980951286 0.0423850725841667 0.0376496510219237 0 0 0 0 K13693 0.16 0.1709401709401709 gpgS; glucosyl-3-phosphoglycerate synthase [EC:2.4.1.266] 167.0 117.0 112.0 2.0 0.959016393442623 M 58.0 64.0 3.0 0.516393442622951 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 122.0 0.4754098360655737 0.5245901639344263 0.0612618623203996 0.244880292060808 0.1530710771906038 0.1836184297404084 0 0 0 0 K13694 0.0 0.0997150997150997 mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] 89.0 45.0 0.0 1.0 1.0 M 0.0 45.0 1.0 1.0 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 45.0 0.0 1.0 0.0086649407404624 0.016961043298543 0.0128129920195027 0.0082961025580806 0 0 0 0 K13695 0.0 0.1339031339031339 nlpC; probable lipoprotein NlpC 75.0 57.0 0.0 1.0 1.0 M 0.0 57.0 1.0 1.0 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 57.0 0.0 1.0 0.0107025906863261 0.0148442852563655 0.0127734379713458 0.0041416945700394 0 0 0 0 K13713 0.02 0.0883190883190883 purCD; fusion protein PurCD [EC:6.3.2.6 6.3.4.13] path:map00230,path:map01100,path:map01110 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 133.0 45.0 0.0 1.0 1.0 F 7.0 38.0 3.0 0.511111111111111 COG0151 Phosphoribosylamine-glycine_ligase PurD 45.0 0.1555555555555555 0.8444444444444444 0.739476243122314 0.329083213613075 0.5342797283676946 0.4103930295092389 0 1 0 1 K13714 0.0 0.0142450142450142 atl; bifunctional autolysin [EC:3.5.1.28 3.2.1.96] path:map00511 Other glycan degradation 946.0 4.0 3.0 2.0 0.8 G 0.0 5.0 4.0 0.4 COG3409 Peptidoglycan-binding_(PGRP)_domain_of_peptidoglycan_hydrolases PGRP 5.0 0.0 1.0 0.0128975629910654 0.027506611293559 0.0202020871423122 0.0146090483024936 0 0 0 0 K13722 0.14 0.0 trf2_3; tricorn protease interacting factor F2/3 [EC:3.4.11.-] 320.0 71.0 0.0 1.0 1.0 E 71.0 0.0 1.0 1.0 COG0308 Aminopeptidase_N,_contains_DUF3458_domain PepN 71.0 1.0 0.0 0.0390920386925983 0.0257051048846796 0.0323985717886389 0.0133869338079187 0 0 0 0 K13726 0.0114285714285714 0.0056980056980056 MEPB; metallopeptidase MepB [EC:3.4.24.-] 653.0 7.0 0.0 1.0 1.0 O 5.0 2.0 1.0 1.0 COG0339 Zn-dependent_oligopeptidase,_M3_family Dcp 7.0 0.7142857142857143 0.2857142857142857 0.0234138357542658 0.0438381019410181 0.0336259688476419 0.0204242661867523 0 0 0 0 K13727 0.0 0.0113960113960113 pdc; phenolic acid decarboxylase [EC:4.1.1.-] 161.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG3479 Phenolic_acid_decarboxylase PadC 4.0 0.0 1.0 0.0087890109644027 0.0299461463649727 0.0193675786646877 0.02115713540057 0 0 0 0 K13730 0.0085714285714285 0.094017094017094 inlA; internalin A path:map05100 Bacterial invasion of epithelial cells 11.0 30.0 25.0 8.0 0.612244897959184 S 3.0 46.0 20.0 0.489795918367347 COG4886 Leucine-rich_repeat_(LRR)_protein LRR 49.0 0.0612244897959183 0.9387755102040816 0.0120130633398161 0.0366448976912939 0.024328980515555 0.0246318343514778 0 0 0 0 K13732 0.0 0.0056980056980056 fnbA; fibronectin-binding protein A path:map05100 Bacterial invasion of epithelial cells 105.0 2.0 0.0 1.0 1.0 M 0.0 2.0 2.0 0.5 COG3266 Cell_division_protein_DamX,_binds_to_the_septal_ring,_contains_C-terminal_SPOR_domain DamX 2.0 0.0 1.0 0 0 0 0 K13733 0.0 0.0056980056980056 fnbB; fibronectin-binding protein B path:map05100 Bacterial invasion of epithelial cells 105.0 2.0 0.0 1.0 1.0 M 0.0 2.0 2.0 0.5 COG3266 Cell_division_protein_DamX,_binds_to_the_septal_ring,_contains_C-terminal_SPOR_domain DamX 2.0 0.0 1.0 0 0 0 0 K13734 0.0 0.0056980056980056 sfb1; fibronectin-binding protein 1 path:map05100 Bacterial invasion of epithelial cells 145.0 1.0 0.0 2.0 0.5 UW 0.0 2.0 2.0 0.5 COG5295 Autotransporter_adhesin Hia 2.0 0.0 1.0 0 0 0 0 K13735 0.0457142857142857 0.1225071225071225 yeeJ; adhesin/invasin path:map05100,path:map05135 Bacterial invasion of epithelial cells,Yersinia infection 11.0 21.0 0.0 13.0 0.225806451612903 M 19.0 64.0 21.0 0.150537634408602 COG2373 Uncharacterized_conserved_protein_YfaS,_alpha-2-macroglobulin_family YfaS 83.0 0.2289156626506024 0.7710843373493976 0.1288347892296 0.303205217309833 0.2160200032697165 0.174370428080233 0 0 0 0 K13740 0.0 0.0028490028490028 sptP; secreted effector protein SptP path:map05100,path:map05132 Bacterial invasion of epithelial cells,Salmonella infection 824.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG5599 Protein_tyrosine_phosphatase 2.0 0.0 1.0 0 0 0 0 K13745 0.0371428571428571 0.1082621082621082 ddc; L-2,4-diaminobutyrate decarboxylase [EC:4.1.1.86] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 325.0 54.0 0.0 1.0 1.0 E 14.0 40.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 54.0 0.2592592592592592 0.7407407407407407 0.116328453260323 0.224929310860177 0.17062888206025 0.108600857599854 0 0 0 0 K13746 0.0057142857142857 0.0142450142450142 cansdh; carboxynorspermidine synthase [EC:1.5.1.43] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 322.0 8.0 0.0 1.0 1.0 E 3.0 5.0 1.0 1.0 COG1748 Saccharopine_dehydrogenase,_NADP-dependent Lys9 8.0 0.375 0.625 0.0747066102112909 0.190708779980572 0.1327076950959314 0.1160021697692811 0 0 0 0 K13747 0.0771428571428571 0.1481481481481481 nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 255.0 70.0 60.0 2.0 0.875 E 27.0 53.0 1.0 1.0 COG0019 Diaminopimelate_decarboxylase LysA 80.0 0.3375 0.6625 0.0450722290275009 0.263761271314101 0.1544167501708009 0.2186890422866 0 0 0 0 K13766 0.0542857142857142 0.2706552706552707 liuC; methylglutaconyl-CoA hydratase [EC:4.2.1.18] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 183.0 121.0 0.0 1.0 1.0 I 19.0 102.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 121.0 0.1570247933884297 0.8429752066115702 0.0082382971997148 0.0585930967083614 0.0334156969540381 0.0503547995086466 0 0 0 0 K13767 0.0028571428571428 0.0569800569800569 fadB; enoyl-CoA hydratase [EC:4.2.1.17] path:map00071,path:map00362,path:map01100,path:map01120,path:map01212 Fatty acid degradation,Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Fatty acid metabolism 224.0 25.0 0.0 1.0 1.0 I 2.0 23.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 25.0 0.08 0.92 0.0186141898947022 0.0227093060836297 0.0206617479891659 0.0040951161889274 0 0 0 0 K13770 0.0 0.0854700854700854 ysiA, fadR; TetR/AcrR family transcriptional regulator, fatty acid metabolism regulator protein 124.0 37.0 36.0 2.0 0.973684210526316 K 0.0 38.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 38.0 0.0 1.0 0.0062201106827866 0.0263031753601105 0.0162616430214485 0.0200830646773239 0 0 0 0 K13771 0.0314285714285714 0.1623931623931624 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor 109.0 80.0 0.0 1.0 1.0 K 14.0 66.0 2.0 0.825 COG1959 DNA-binding_transcriptional_regulator,_IscR_family IscR 80.0 0.175 0.825 0.0038392005694017 0.0203983261631359 0.0121187633662688 0.0165591255937341 0 0 0 0 K13772 0.0 0.0113960113960113 rirA; Rrf2 family transcriptional regulator, iron-responsive regulator 144.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG1959 DNA-binding_transcriptional_regulator,_IscR_family IscR 5.0 0.0 1.0 0.0068588118292289 0.014306064237594 0.0105824380334114 0.0074472524083651 0 0 0 0 K13774 0.0028571428571428 0.0797720797720797 atuB; citronellol/citronellal dehydrogenase path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 240.0 30.0 0.0 1.0 1.0 IQ 1.0 29.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 30.0 0.0333333333333333 0.9666666666666668 0.0053739070226342 0.0175778104840289 0.0114758587533315 0.0122039034613946 0 0 0 0 K13775 0.0571428571428571 0.074074074074074 atuG; citronellol/citronellal dehydrogenase path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 258.0 28.0 9.0 3.0 0.549019607843137 IQ 20.0 31.0 2.0 0.980392156862745 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 51.0 0.392156862745098 0.6078431372549019 0.005312734895125 0.385920413416491 0.195616574155808 0.380607678521366 0 0 0 0 K13776 0.0028571428571428 0.0056980056980056 atuH; citronellyl-CoA synthetase [EC:6.2.1.-] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 584.0 4.0 0.0 1.0 1.0 IQ 1.0 3.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 4.0 0.25 0.75 0.0039770916075783 0.0149776123106685 0.0094773519591234 0.0110005207030902 0 0 0 0 K13777 0.0028571428571428 0.0313390313390313 atuF; geranyl-CoA carboxylase alpha subunit [EC:6.4.1.5] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 606.0 12.0 0.0 1.0 1.0 I 1.0 11.0 1.0 1.0 COG4770 Acetyl/propionyl-CoA_carboxylase,_alpha_subunit PccA 12.0 0.0833333333333333 0.9166666666666666 0.0065786624480357 0.0456378335987196 0.0261082480233776 0.0390591711506839 0 0 0 0 K13778 0.0228571428571428 0.0427350427350427 atuC; geranyl-CoA carboxylase beta subunit [EC:6.4.1.5] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 502.0 24.0 0.0 1.0 1.0 I 9.0 15.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 24.0 0.375 0.625 0.00092131776732 0.0070837441908155 0.0040025309790677 0.0061624264234955 0 0 0 0 K13779 0.0028571428571428 0.0313390313390313 atuE; isohexenylglutaconyl-CoA hydratase [EC:4.2.1.57] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 205.0 14.0 0.0 1.0 1.0 I 1.0 13.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 14.0 0.0714285714285714 0.9285714285714286 0.0430775282119708 0.0677773436687111 0.0554274359403409 0.0246998154567403 0 0 0 0 K13786 0.0 0.0113960113960113 cobR; cob(II)yrinic acid a,c-diamide reductase [EC:1.16.8.-] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 156.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 4.0 0.0 1.0 0.0071849009966419 0.0159787949447896 0.0115818479707157 0.0087938939481476 0 0 0 0 K13787 0.8085714285714286 0.2136752136752136 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 89.0 527.0 526.0 2.0 0.998106060606061 H 430.0 98.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 528.0 0.8143939393939394 0.1856060606060606 0.0118025464542292 0.0099296329467941 0.0108660897005116 0.001872913507435 0 0 0 0 K13788 0.0114285714285714 0.2165242165242165 pta; phosphate acetyltransferase [EC:2.3.1.8] path:map00430,path:map00620,path:map00640,path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Taurine and hypotaurine metabolism,Pyruvate metabolism,Propanoate metabolism,Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 279.0 89.0 85.0 2.0 0.956989247311828 C 4.0 89.0 2.0 0.978494623655914 COG0280 Phosphotransacetylase_(includes_Pta,_EutD_and_phosphobutyryltransferase) Pta 93.0 0.043010752688172 0.956989247311828 0.0094342989664568 0.0147291891294221 0.0120817440479394 0.0052948901629652 0 0 0 0 K13789 0.0457142857142857 0.6410256410256411 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 150.0 273.0 272.0 2.0 0.996350364963504 H 16.0 258.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 274.0 0.0583941605839416 0.9416058394160584 0.0431567869239669 0.846662043784262 0.4449094153541144 0.8035052568602952 0 0 0 0 K13790 0.0 0.0028490028490028 icsB, bopA; virulence protein IcsB path:map05131 Shigellosis 368.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2CK6D 1.0 0.0 1.0 0 0 0 0 K13791 0.0028571428571428 0.0085470085470085 ipaH9.8; invasion plasmid antigen path:map05131 Shigellosis 53.0 5.0 0.0 1.0 1.0 S 2.0 3.0 1.0 1.0 COG4886 Leucine-rich_repeat_(LRR)_protein LRR 5.0 0.4 0.6 5.09298465959708e-12 0.092099364993364 0.0460496824992284 0.092099364988271 0 0 0 0 K13792 0.0142857142857142 0.0113960113960113 ospG; secreted effector OspG path:map05131 Shigellosis 369.0 6.0 2.0 2.0 0.6 S 5.0 5.0 1.0 1.0 COG0661 Predicted_protein_kinase_regulating_ubiquinone_biosynthesis,_AarF/ABC1/UbiB_family AarF 10.0 0.5 0.5 0.0155569474697559 0.05853552351973 0.0370462354947429 0.0429785760499741 0 0 0 0 K13794 0.0 0.0142450142450142 tcuR; LysR family transcriptional regulator, regulatory protein for tcuABC 93.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 6.0 0.0 1.0 0.0366894928972415 0.0788410629421027 0.0577652779196721 0.0421515700448612 0 0 0 0 K13795 0.0 0.0712250712250712 citB, tcuB; citrate/tricarballylate utilization protein 54.0 32.0 0.0 1.0 1.0 C 0.0 31.0 7.0 0.40625 COG1146 NAD-dependent_dihydropyrimidine_dehydrogenase,_PreA_subunit PreA 31.0 0.0 1.0 0.0103292399801828 0.0187226481463899 0.0145259440632863 0.0083934081662071 0 0 0 0 K13796 0.0085714285714285 0.0769230769230769 cobZ, tcuA; tricarballylate dehydrogenase 327.0 36.0 0.0 1.0 1.0 C 3.0 33.0 3.0 0.861111111111111 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 36.0 0.0833333333333333 0.9166666666666666 0.0270267636223721 0.0383676540929067 0.0326972088576393 0.0113408904705345 0 0 0 0 K13797 0.0 0.1538461538461538 rpoBC; DNA-directed RNA polymerase subunit beta-beta' [EC:2.7.7.6] path:map03020 RNA polymerase 825.0 60.0 59.0 2.0 0.983606557377049 K 0.0 61.0 3.0 0.508196721311475 COG0085 DNA-directed_RNA_polymerase,_beta_subunit/140_kD_subunit RpoB 61.0 0.0 1.0 0.0154644914365748 0.0177950703110741 0.0166297808738244 0.0023305788744993 0 0 0 0 K13798 0.6914285714285714 0.0 rpoB; DNA-directed RNA polymerase subunit B [EC:2.7.7.6] path:map03020 RNA polymerase 287.0 291.0 0.0 1.0 1.0 K 274.0 0.0 1.0 1.0 COG0085 DNA-directed_RNA_polymerase,_beta_subunit/140_kD_subunit RpoB 274.0 1.0 0.0 0.146649628081109 0.320441519400203 0.233545573740656 0.1737918913190939 0 0 0 0 K13799 0.0 0.0769230769230769 panC-cmk; pantoate ligase / CMP/dCMP kinase [EC:6.3.2.1 2.7.4.25] path:map00240,path:map00410,path:map00770,path:map01100,path:map01110,path:map01232,path:map01240 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism,Biosynthesis of cofactors 203.0 25.0 20.0 3.0 0.735294117647059 F 0.0 28.0 3.0 0.823529411764706 COG0283 Cytidylate_kinase Cmk 28.0 0.0 1.0 0.582870291128483 0.308816400711674 0.4458433459200784 0.274053890416809 0 0 0 1 K13800 0.0028571428571428 0.0028490028490028 CMPK1, UMPK; UMP-CMP kinase [EC:2.7.4.14] path:map00240,path:map00983,path:map01100,path:map01232,path:map01240 Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways,Nucleotide metabolism,Biosynthesis of cofactors 134.0 1.0 0.0 2.0 0.5 O 1.0 1.0 2.0 0.5 COG2940 SET_domain-containing_protein_(function_unknown) SET 2.0 0.5 0.5 0 0 0 0 K13810 0.0371428571428571 0.1396011396011396 tal-pgi; transaldolase / glucose-6-phosphate isomerase [EC:2.2.1.2 5.3.1.9] path:map00010,path:map00030,path:map00500,path:map00520,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230,path:map01250 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids,Biosynthesis of nucleotide sugars 214.0 65.0 63.0 3.0 0.955882352941176 G 13.0 53.0 2.0 0.911764705882353 COG0166 Glucose-6-phosphate_isomerase Pgi 66.0 0.1969696969696969 0.803030303030303 0.0542025335563283 0.812368043329361 0.4332852884428446 0.7581655097730327 0 0 0 0 K13811 0.02 0.0484330484330484 PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25] path:map00230,path:map00261,path:map00450,path:map00920,path:map01100,path:map01110,path:map01120 Purine metabolism,Monobactam biosynthesis,Selenocompound metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 11.0 26.0 23.0 2.0 0.896551724137931 P 8.0 17.0 2.0 0.517241379310345 COG0529 Adenylylsulfate_kinase_or_related_kinase CysC 25.0 0.32 0.68 0.0078745777367309 0.0151310725434115 0.0115028251400711 0.0072564948066806 0 0 0 0 K13812 0.2085714285714285 0.0056980056980056 fae-hps; bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43] path:map00030,path:map00680,path:map01100,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 378.0 55.0 28.0 2.0 0.670731707317073 F 79.0 3.0 1.0 1.0 COG0269 3-keto-L-gulonate-6-phosphate_decarboxylase UlaD 82.0 0.9634146341463414 0.0365853658536585 0.784878712106569 0.014761172081564 0.3998199420940665 0.770117540025005 0 0 1 1 K13815 0.0 0.017094017094017 rpfG; two-component system, response regulator RpfG path:map02020,path:map02024 Two-component system,Quorum sensing 247.0 7.0 0.0 1.0 1.0 T 0.0 7.0 1.0 1.0 COG3437 Response_regulator_c-di-GMP_phosphodiesterase,_RpfG_family,_contains_REC_and_HD-GYP_domains RpfG 7.0 0.0 1.0 0.87599534613395 0.0535742781309203 0.4647848121324351 0.8224210680030297 0 0 1 1 K13816 0.0 0.017094017094017 rpfF; DSF synthase path:map02020,path:map02024 Two-component system,Quorum sensing 278.0 6.0 0.0 1.0 1.0 I 0.0 6.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 6.0 0.0 1.0 1.36603099476944e-12 5.7486654566914e-12 3.5573482257304196e-12 4.38263446192196e-12 0 0 0 0 K13818 0.0542857142857142 0.1481481481481481 mobAB; molybdopterin-guanine dinucleotide biosynthesis protein [EC:2.7.7.77] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 35.0 80.0 0.0 1.0 1.0 H 19.0 61.0 2.0 0.5875 COG0746 Molybdopterin-guanine_dinucleotide_biosynthesis_protein_A MobA 80.0 0.2375 0.7625 0.240390263767496 0.697127890777746 0.468759077272621 0.4567376270102499 0 0 0 0 K13819 0.0142857142857142 0.1452991452991453 K13819; NifU-like protein 121.0 28.0 6.0 6.0 0.430769230769231 CO 6.0 59.0 4.0 0.6 COG0694 Fe-S_cluster_biogenesis_protein_NfuA,_4Fe-4S-binding_domain NifU 65.0 0.0923076923076923 0.9076923076923076 0.0051188049692727 0.0120735952262097 0.0085962000977411 0.006954790256937 0 0 0 0 K13820 0.0028571428571428 0.0997150997150997 fliR-flhB; flagellar biosynthesis protein FliR/FlhB path:map02040 Flagellar assembly 143.0 42.0 40.0 2.0 0.954545454545455 N 1.0 43.0 2.0 0.772727272727273 COG1377 Flagellar_biosynthesis_protein_FlhB FlhB 44.0 0.0227272727272727 0.9772727272727272 0.328146206085543 0.615601553160938 0.4718738796232405 0.287455347075395 0 0 0 0 K13821 0.0142857142857142 0.3418803418803419 putA; RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88] path:map00250,path:map00330,path:map01100,path:map01110 Alanine, aspartate and glutamate metabolism,Arginine and proline metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 297.0 75.0 27.0 4.0 0.539568345323741 C 5.0 134.0 6.0 0.705035971223022 COG0506 Proline_dehydrogenase PutA 139.0 0.0359712230215827 0.9640287769784172 0.0094524401637048 0.0367237118936194 0.0230880760286621 0.0272712717299146 0 0 0 0 K13829 0.0257142857142857 0.3703703703703703 aroKB; shikimate kinase / 3-dehydroquinate synthase [EC:2.7.1.71 4.2.3.4] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 215.0 131.0 96.0 3.0 0.752873563218391 E 9.0 149.0 3.0 0.827586206896552 COG0337 3-dehydroquinate_synthetase AroB 158.0 0.0569620253164556 0.9430379746835444 0.327440373735784 0.751860768976535 0.5396505713561595 0.424420395240751 0 0 0 0 K13830 0.0 0.0028490028490028 ARO1; pentafunctional AROM polypeptide [EC:4.2.3.4 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19] path:map00400,path:map00999,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 637.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0169 Shikimate_5-dehydrogenase AroE 1.0 0.0 1.0 0 0 0 0 K13831 0.2742857142857143 0.0199430199430199 hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27] path:map00030,path:map00680,path:map01100,path:map01120,path:map01200,path:map01230 Pentose phosphate pathway,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 171.0 105.0 101.0 2.0 0.963302752293578 G 102.0 7.0 2.0 0.972477064220184 COG0269 3-keto-L-gulonate-6-phosphate_decarboxylase UlaD 109.0 0.9357798165137616 0.0642201834862385 0.945151930812987 0.325010250782758 0.6350810907978726 0.620141680030229 1 1 1 1 K13832 0.0828571428571428 0.0626780626780626 aroDE, DHQ-SDH; 3-dehydroquinate dehydratase / shikimate dehydrogenase [EC:4.2.1.10 1.1.1.25] path:map00400,path:map00999,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Biosynthesis of various plant secondary metabolites; Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 99.0 57.0 0.0 1.0 1.0 E 30.0 24.0 3.0 0.947368421052632 COG0169 Shikimate_5-dehydrogenase AroE 54.0 0.5555555555555556 0.4444444444444444 0.0305256228182731 0.0464816536118845 0.0385036382150788 0.0159560307936114 0 0 0 0 K13853 0.0028571428571428 0.0683760683760683 aroG, aroA; 3-deoxy-7-phosphoheptulonate synthase / chorismate mutase [EC:2.5.1.54 5.4.99.5] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 241.0 25.0 24.0 2.0 0.961538461538462 E 1.0 25.0 2.0 0.538461538461538 COG2876 3-deoxy-D-arabino-heptulosonate_7-phosphate_(DAHP)_synthase AroGA 26.0 0.0384615384615384 0.9615384615384616 0.0163971374339689 0.0866323552278235 0.0515147463308962 0.0702352177938546 0 0 0 0 K13854 0.0 0.0056980056980056 K13854, glf; MFS transporter, SP family, glucose uniporter 307.0 2.0 0.0 1.0 1.0 EGP 0.0 2.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 2.0 0.0 1.0 0 0 0 0 K13868 0.0 0.0085470085470085 SLC7A9_15, BAT1; solute carrier family 7 (L-type amino acid transporter), member 9/15 path:map04974 Protein digestion and absorption 425.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 3.0 0.0 1.0 0 0 0 0 K13874 0.0 0.0541310541310541 araB; L-arabinonolactonase [EC:3.1.1.15] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 206.0 22.0 21.0 2.0 0.956521739130435 G 0.0 23.0 2.0 0.956521739130435 COG3386 Sugar_lactone_lactonase_YvrE YvrE 23.0 0.0 1.0 0.03479596002379 0.0995242916766711 0.0671601258502305 0.0647283316528811 0 0 0 0 K13875 0.0 0.0256410256410256 araC; L-arabonate dehydrase [EC:4.2.1.25] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 572.0 11.0 0.0 1.0 1.0 EG 0.0 11.0 1.0 1.0 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 11.0 0.0 1.0 0.0278014601310486 0.0717630569084891 0.0497822585197688 0.0439615967774404 0 0 0 0 K13876 0.0028571428571428 0.0199430199430199 araD; 2-keto-3-deoxy-L-arabinonate dehydratase [EC:4.2.1.43] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 295.0 6.0 4.0 2.0 0.75 EM 1.0 7.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 8.0 0.125 0.875 0.0731561987890719 0.166753483683617 0.1199548412363444 0.0935972848945451 0 0 0 0 K13877 0.0 0.1139601139601139 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] path:map00040,path:map00053,path:map00470,path:map01100 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,D-Amino acid metabolism,Metabolic pathways 478.0 47.0 0.0 1.0 1.0 C 0.0 47.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 47.0 0.0 1.0 0.0362941876645974 0.0373954744140676 0.0368448310393325 0.0011012867494702 0 0 0 0 K13888 0.0 0.2735042735042735 macA; membrane fusion protein, macrolide-specific efflux system 109.0 123.0 122.0 3.0 0.984 M 0.0 125.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 125.0 0.0 1.0 0.204934097768067 0.514792001208399 0.359863049488233 0.3098579034403319 0 0 0 0 K13889 0.0028571428571428 0.0541310541310541 gsiB; glutathione transport system substrate-binding protein path:map02010 ABC transporters 360.0 24.0 0.0 1.0 1.0 E 1.0 23.0 1.0 1.0 COG0747 ABC-type_transport_system,_periplasmic_component DdpA 24.0 0.0416666666666666 0.9583333333333334 0.0611760060925941 0.240630262964655 0.1509031345286245 0.1794542568720609 0 0 0 0 K13890 0.0 0.0427350427350427 gsiC; glutathione transport system permease protein path:map02010 ABC transporters 304.0 11.0 1.0 3.0 0.458333333333333 P 0.0 24.0 1.0 1.0 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 24.0 0.0 1.0 0.0213367486676953 0.0565051384866188 0.038920943577157 0.0351683898189234 0 0 0 0 K13891 0.0028571428571428 0.0541310541310541 gsiD; glutathione transport system permease protein path:map02010 ABC transporters 262.0 10.0 1.0 4.0 0.476190476190476 P 1.0 20.0 1.0 1.0 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 21.0 0.0476190476190476 0.9523809523809524 0.0671429301234029 0.221500815647944 0.1443218728856734 0.1543578855245411 0 0 0 0 K13892 0.0085714285714285 0.0484330484330484 gsiA; glutathione transport system ATP-binding protein path:map02010 ABC transporters 467.0 57.0 0.0 1.0 1.0 P 3.0 54.0 2.0 0.912280701754386 COG1123 ABC-type_glutathione_transport_system_ATPase_component,_contains_duplicated_ATPase_domain GsiA 57.0 0.0526315789473684 0.9473684210526316 0.0168349285584174 0.0130977908233694 0.0149663596908934 0.003737137735048 0 0 0 0 K13893 0.0 0.1937321937321937 yejA; microcin C transport system substrate-binding protein path:map02010 ABC transporters 333.0 96.0 0.0 1.0 1.0 E 0.0 96.0 2.0 0.833333333333333 COG4166 ABC-type_oligopeptide_transport_system,_periplasmic_component OppA 96.0 0.0 1.0 0.0019894651711936 0.0060525129962915 0.0040209890837425 0.0040630478250979 0 0 0 0 K13894 0.0 0.1452991452991453 yejB; microcin C transport system permease protein path:map02010 ABC transporters 332.0 51.0 49.0 2.0 0.962264150943396 P 0.0 53.0 2.0 0.867924528301887 COG4174 ABC-type_microcin_C_transport_system,_permease_component_YejB YejB 53.0 0.0 1.0 0.0165581835556748 0.232479735770382 0.1245189596630284 0.2159215522147072 0 0 0 0 K13895 0.0 0.1367521367521367 yejE; microcin C transport system permease protein path:map02010 ABC transporters 315.0 48.0 0.0 1.0 1.0 P 0.0 48.0 1.0 1.0 COG4239 ABC-type_microcin_C_transport_system,_permease_component_YejE YejE 48.0 0.0 1.0 0.0135534866080824 0.0589077788006437 0.036230632704363 0.0453542921925613 0 0 0 0 K13896 0.0 0.1424501424501424 yejF; microcin C transport system ATP-binding protein path:map02010 ABC transporters 446.0 97.0 0.0 1.0 1.0 P 0.0 97.0 1.0 1.0 COG1123 ABC-type_glutathione_transport_system_ATPase_component,_contains_duplicated_ATPase_domain GsiA 97.0 0.0 1.0 0.0044518093899104 0.0092425441887924 0.0068471767893514 0.004790734798882 0 0 0 0 K13912 0.0 0.0028490028490028 DMBT1; deleted in malignant brain tumors 1 protein path:map04970 Salivary secretion 242.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2CXZ5 1.0 0.0 1.0 0 0 0 0 K13918 0.0 0.0028490028490028 gudX; glucarate dehydratase-related protein 446.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 1.0 0.0 1.0 0 0 0 0 K13919 0.0028571428571428 0.0199430199430199 pduD; propanediol dehydratase medium subunit [EC:4.2.1.28] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 211.0 8.0 0.0 1.0 1.0 Q 1.0 7.0 1.0 1.0 COG4909 Propanediol_dehydratase,_large_subunit PduC 8.0 0.125 0.875 0.0108808410330472 0.0786692542908302 0.0447750476619387 0.067788413257783 0 0 0 0 K13920 0.0028571428571428 0.0227920227920227 pduE; propanediol dehydratase small subunit [EC:4.2.1.28] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 128.0 10.0 0.0 1.0 1.0 Q 1.0 9.0 1.0 1.0 COG4910 Propanediol_dehydratase,_small_subunit PduE 10.0 0.1 0.9 0.0064275241144319 0.0368077002353617 0.0216176121748968 0.0303801761209298 0 0 0 0 K13921 0.0028571428571428 0.0056980056980056 pduQ; 1-propanol dehydrogenase path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 331.0 3.0 0.0 1.0 1.0 C 1.0 2.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K13922 0.0028571428571428 0.0626780626780626 pduP; propionaldehyde dehydrogenase [EC:1.2.1.87] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 413.0 29.0 0.0 1.0 1.0 C 1.0 28.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 29.0 0.0344827586206896 0.9655172413793104 0.0435550276840345 0.212514386705696 0.1280347071948652 0.1689593590216615 0 0 0 0 K13923 0.0 0.0028490028490028 pduL; phosphate propanoyltransferase [EC:2.3.1.222] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 218.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG4869 Propanediol_utilization_protein PduL 1.0 0.0 1.0 0 0 0 0 K13924 0.0 0.0 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] path:map02020,path:map02030 Two-component system,Bacterial chemotaxis 159.0 84.0 15.0 0.584558823529412 T 0.0 0.0 46.0 0.254545454545455 COG1352 Methylase_of_chemotaxis_methyl-accepting_proteins CheR 0.0 0 0 0 0 K13925 0.0057142857142857 0.0028490028490028 pfbA; plasmin and fibronectin-binding protein A path:map05100 Bacterial invasion of epithelial cells 141.0 3.0 0.0 1.0 1.0 M 2.0 1.0 1.0 1.0 COG5434 Polygalacturonase Pgu1 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K13926 0.0057142857142857 0.1054131054131054 rbbA; ribosome-dependent ATPase 526.0 31.0 20.0 3.0 0.704545454545455 V 2.0 42.0 3.0 0.727272727272727 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 44.0 0.0454545454545454 0.9545454545454546 0.0392236324101849 0.0649859973491748 0.0521048148796798 0.0257623649389899 0 0 0 0 K13927 0.0057142857142857 0.0199430199430199 citXG; holo-ACP synthase / triphosphoribosyl-dephospho-CoA synthase [EC:2.7.7.61 2.4.2.52] path:map02020 Two-component system 239.0 10.0 9.0 2.0 0.909090909090909 H 2.0 9.0 1.0 1.0 COG1767 Triphosphoribosyl-dephospho-CoA_synthetase CitG 11.0 0.1818181818181818 0.8181818181818182 0.0517674631126018 0.209515180929744 0.1306413220211729 0.1577477178171422 0 0 0 0 K13928 0.0 0.0056980056980056 mdcR; LysR family transcriptional regulator, malonate utilization transcriptional regulator 299.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K13929 0.0028571428571428 0.017094017094017 mdcA; malonate decarboxylase alpha subunit [EC:2.3.1.187] 542.0 6.0 5.0 2.0 0.857142857142857 I 1.0 6.0 2.0 0.857142857142857 COG4670 Acyl_CoA:acetate/3-ketoacid_CoA_transferase YdiF 7.0 0.1428571428571428 0.8571428571428571 0.0181517751626717 0.116132685452827 0.0671422303077493 0.0979809102901553 0 0 0 0 K13930 0.0028571428571428 0.0256410256410256 mdcB; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] 253.0 8.0 7.0 3.0 0.8 H 1.0 9.0 1.0 1.0 COG1767 Triphosphoribosyl-dephospho-CoA_synthetase CitG 10.0 0.1 0.9 0.165659970998305 0.417941544380373 0.291800757689339 0.252281573382068 0 0 0 0 K13931 0.0028571428571428 0.0142450142450142 mdcC; malonate decarboxylase delta subunit 98.0 6.0 0.0 1.0 1.0 C 1.0 5.0 1.0 1.0 COG3052 Acyl-carrier_protein_(citrate_lyase_gamma_subunit) CitD 6.0 0.1666666666666666 0.8333333333333334 0.0966465101210668 0.209892469769041 0.1532694899450539 0.1132459596479742 0 0 0 0 K13932 0.0028571428571428 0.0142450142450142 mdcD; malonate decarboxylase beta subunit [EC:4.1.1.87] 270.0 6.0 0.0 1.0 1.0 I 1.0 5.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 6.0 0.1666666666666666 0.8333333333333334 0.0302740925842048 0.116077668865654 0.0731758807249294 0.0858035762814492 0 0 0 0 K13933 0.0 0.017094017094017 mdcE; malonate decarboxylase gamma subunit [EC:4.1.1.87] 220.0 6.0 0.0 1.0 1.0 I 0.0 6.0 2.0 0.833333333333333 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 6.0 0.0 1.0 0.0150315979589542 0.0762249611173972 0.0456282795381757 0.0611933631584429 0 0 0 0 K13934 0.0028571428571428 0.0142450142450142 mdcG; phosphoribosyl-dephospho-CoA transferase [EC:2.7.7.66] 180.0 3.0 0.0 2.0 0.5 S 1.0 5.0 3.0 0.5 28INI 6.0 0.1666666666666666 0.8333333333333334 0.0810905801983321 0.144084024719264 0.112587302458798 0.0629934445209318 0 0 0 0 K13935 0.0 0.0199430199430199 mdcH; malonate decarboxylase epsilon subunit [EC:2.3.1.39] 297.0 7.0 0.0 1.0 1.0 I 0.0 7.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 7.0 0.0 1.0 0.0045588690255144 0.0379452434762713 0.0212520562508928 0.0333863744507569 0 0 0 0 K13936 0.0028571428571428 0.0085470085470085 mdcF; malonate transporter and related proteins 282.0 4.0 0.0 1.0 1.0 S 1.0 3.0 1.0 1.0 COG0679 Predicted_permease,_AEC_(auxin_efflux_carrier)_family YfdV 4.0 0.25 0.75 0.0715265693503682 0.161829355380646 0.116677962365507 0.0903027860302777 0 0 0 0 K13937 0.0 0.0028490028490028 H6PD; hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31] path:map00030,path:map01100,path:map01110,path:map01200 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 220.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate_isomerase/deaminase NagB 1.0 0.0 1.0 0 0 0 0 K13938 0.0 0.0142450142450142 folM; dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3] path:map00670,path:map00790,path:map01100 One carbon pool by folate,Folate biosynthesis,Metabolic pathways 231.0 5.0 0.0 1.0 1.0 IQ 0.0 5.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 5.0 0.0 1.0 0.0065521235816583 0.0362630979704619 0.0214076107760601 0.0297109743888036 0 0 0 0 K13940 0.0 0.0 sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 126.0 0.0 1.0 1.0 H 0.0 0.0 4.0 0.76984126984127 COG0801 7,8-dihydro-6-hydroxymethylpterin_pyrophosphokinase_(folate_biosynthesis) FolK 0.0 0 0 0 0 K13941 0.0228571428571428 0.1709401709401709 folKP; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.7.6.3 2.5.1.15] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 203.0 69.0 0.0 1.0 1.0 H 8.0 61.0 2.0 0.927536231884058 COG0294 Dihydropteroate_synthase FolP 69.0 0.1159420289855072 0.8840579710144928 0.0185685991193763 0.0173656839217228 0.0179671415205495 0.0012029151976535 0 0 0 0 K13942 0.0342857142857142 0.0 hmd; 5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 333.0 12.0 0.0 1.0 1.0 C 12.0 0.0 1.0 1.0 COG4007 Predicted_dehydrogenase_related_to_H2-forming_N5,N10-methylenetetrahydromethanopterin_dehydrogenase 12.0 1.0 0.0 0.0062098456214295 0.0037592543059695 0.0049845499636995 0.00245059131546 0 0 0 0 K13950 0.0028571428571428 0.1481481481481481 pabAB; para-aminobenzoate synthetase [EC:2.6.1.85] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 227.0 54.0 51.0 5.0 0.9 EH 1.0 58.0 6.0 0.683333333333333 COG0147 Anthranilate/para-aminobenzoate_synthases_component_I TrpE 59.0 0.0169491525423728 0.9830508474576272 0.214620914308928 0.292407298932378 0.253514106620653 0.07778638462345 0 0 0 0 K13953 0.2085714285714285 0.301994301994302 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] path:map00010,path:map00071,path:map00350,path:map00620,path:map00625,path:map00626,path:map00830,path:map00980,path:map00982,path:map01100,path:map01110,path:map01120,path:map01220 Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Naphthalene degradation,Retinol metabolism,Metabolism of xenobiotics by cytochrome P450,Drug metabolism - cytochrome P450,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds 195.0 142.0 40.0 4.0 0.546153846153846 C 102.0 158.0 2.0 0.988461538461538 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 260.0 0.3923076923076923 0.6076923076923076 0.317013197787921 0.478474513745398 0.3977438557666595 0.161461315957477 0 0 0 0 K13954 0.0542857142857142 0.1737891737891738 yiaY; alcohol dehydrogenase [EC:1.1.1.1] path:map00010,path:map00071,path:map00350,path:map00620,path:map00625,path:map00626,path:map01100,path:map01110,path:map01120,path:map01220 Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Naphthalene degradation,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Degradation of aromatic compounds 245.0 100.0 0.0 1.0 1.0 C 23.0 77.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 100.0 0.23 0.77 0.469349345228095 0.835975186964522 0.6526622660963085 0.366625841736427 0 0 0 0 K13955 0.0 0.0284900284900284 yogA; zinc-binding alcohol dehydrogenase/oxidoreductase 327.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 11.0 0.0 1.0 0.0148330839565764 0.027750861257436 0.0212919726070062 0.0129177773008596 0 0 0 0 K13960 0.0285714285714285 0.0 UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] path:map03460 Fanconi anemia pathway 144.0 11.0 0.0 1.0 1.0 O 11.0 0.0 1.0 1.0 COG5078 Ubiquitin-protein_ligase 11.0 1.0 0.0 0.917614306548645 0.922351152431024 0.9199827294898344 0.0047368458823789 0 0 1 1 K13963 0.12 0.1623931623931624 SERPINB; serpin B path:map05146 Amoebiasis 140.0 117.0 109.0 5.0 0.879699248120301 O 70.0 64.0 6.0 0.940298507462687 COG4826 Serine_protease_inhibitor SERPIN 134.0 0.5223880597014925 0.4776119402985074 0.962875424016196 0.742910419957957 0.8528929219870764 0.2199650040582389 1 1 1 1 K13967 0.0 0.0341880341880341 nanEK; N-acetylmannosamine-6-phosphate 2-epimerase / N-acetylmannosamine kinase [EC:5.1.3.9 2.7.1.60] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 236.0 11.0 6.0 2.0 0.6875 GK 0.0 13.0 2.0 0.8125 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 13.0 0.0 1.0 0.0460896974469089 0.136640204949093 0.0913649511980009 0.0905505075021841 0 0 0 0 K13979 0.02 0.1709401709401709 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2] path:map00010,path:map00561,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Glycerolipid metabolism,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 299.0 47.0 15.0 3.0 0.552941176470588 S 9.0 76.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 85.0 0.1058823529411764 0.8941176470588236 0.0417867626463837 0.0442707283357231 0.0430287454910534 0.0024839656893393 0 0 0 0 K13984 0.0028571428571428 0.0 TXNDC5, ERP46; thioredoxin domain-containing protein 5 path:map04141 Protein processing in endoplasmic reticulum 457.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG0526 Thiol-disulfide_isomerase_or_thioredoxin TrxA 1.0 1.0 0.0 0 0 0 0 K13985 0.0 0.0085470085470085 NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [EC:3.1.4.54] path:map04723 Retrograde endocannabinoid signaling 307.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG2220 L-ascorbate_lactonase_UlaG,_metallo-beta-lactamase_superfamily UlaG 3.0 0.0 1.0 0 0 0 0 K13987 0.0028571428571428 0.0 NUDT5; ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase [EC:3.6.1.13 3.6.1.58 2.7.7.96] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 185.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 1.0 1.0 0.0 0 0 0 0 K13990 0.0885714285714285 0.1225071225071225 FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] path:map00340,path:map00670,path:map01100 Histidine metabolism,One carbon pool by folate,Metabolic pathways 271.0 84.0 0.0 1.0 1.0 E 34.0 47.0 2.0 0.666666666666667 COG3404 Formiminotetrahydrofolate_cyclodeaminase FtcD 81.0 0.419753086419753 0.5802469135802469 0.0595808195991436 0.472262793977756 0.2659218067884498 0.4126819743786124 0 0 0 0 K13991 0.0 0.0341880341880341 puhA; photosynthetic reaction center H subunit path:map02020 Two-component system 118.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG3861 Stress_response_protein_YsnF_(function_unknown) YsnF 13.0 0.0 1.0 0.0367858302207045 0.0832670731743144 0.0600264516975094 0.0464812429536098 0 0 0 0 K13992 0.0 0.0455840455840455 pufC; photosynthetic reaction center cytochrome c subunit 86.0 11.0 5.0 2.0 0.647058823529412 C 0.0 17.0 2.0 0.647058823529412 2DB8Q 17.0 0.0 1.0 0.0543781411985215 0.0819170532884465 0.068147597243484 0.027538912089925 0 0 0 0 K13993 0.0 0.0 HSP20; HSP20 family protein path:map04141 Protein processing in endoplasmic reticulum 1048.0 1038.0 3.0 0.984962406015038 O 0.0 0.0 3.0 0.984962406015038 COG0071 Small_heat_shock_protein_IbpA,_HSP20_family IbpA 0.0 0 0 0 0 K13995 0.0028571428571428 0.037037037037037 nicF; maleamate amidohydrolase [EC:3.5.1.107] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 187.0 16.0 0.0 1.0 1.0 Q 1.0 15.0 1.0 1.0 COG1335 Nicotinamidase-related_amidase PncA 16.0 0.0625 0.9375 0.0060824952195054 0.0154513870956788 0.0107669411575921 0.0093688918761734 0 0 0 0 K14012 0.0028571428571428 0.0028490028490028 NSFL1C, UBX1, SHP1; UBX domain-containing protein 1 path:map04141 Protein processing in endoplasmic reticulum 394.0 2.0 0.0 1.0 1.0 O 1.0 1.0 1.0 1.0 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 2.0 0.5 0.5 0 0 0 0 K14026 0.0028571428571428 0.0 SEL1, SEL1L; SEL1 protein path:map04141 Protein processing in endoplasmic reticulum 188.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG0790 TPR_repeat TPR 1.0 1.0 0.0 0 0 0 0 K14028 0.0 0.017094017094017 mdh1, mxaF; methanol dehydrogenase (cytochrome c) subunit 1 [EC:1.1.2.7] path:map00010,path:map00620,path:map00625,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 551.0 7.0 0.0 1.0 1.0 G 0.0 7.0 1.0 1.0 COG4993 Glucose_dehydrogenase,_PQQ-dependent Gcd 7.0 0.0 1.0 0.035269250324927 0.0727799229172226 0.0540245866210748 0.0375106725922956 0 0 0 0 K14029 0.0 0.0085470085470085 mdh2, mxaI; methanol dehydrogenase (cytochrome c) subunit 2 [EC:1.1.2.7] path:map00010,path:map00620,path:map00625,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Chloroalkane and chloroalkene degradation,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 95.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 2D1SQ 3.0 0.0 1.0 0 0 0 0 K14043 0.0057142857142857 0.0 CPS4; syn-copalyl-diphosphate synthase [EC:5.5.1.14] path:map00904,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Biosynthesis of secondary metabolites 481.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 2CKJS 2.0 1.0 0.0 0 0 0 0 K14048 0.0 0.0 ureAB; urease subunit gamma/beta [EC:3.5.1.5] path:map00220,path:map00230,path:map00791,path:map01100,path:map01120,path:map05120 Arginine biosynthesis,Purine metabolism,Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments,Epithelial cell signaling in Helicobacter pylori infection 55.0 0.0 1.0 1.0 E 0.0 0.0 2.0 0.709090909090909 COG0831 Urease_gamma_subunit UreA 0.0 0 0 0 0 K14051 0.0 0.0227920227920227 gmr; c-di-GMP phosphodiesterase Gmr [EC:3.1.4.52] path:map02024,path:map02026 Quorum sensing,Biofilm formation - Escherichia coli 172.0 12.0 0.0 1.0 1.0 T 0.0 12.0 3.0 0.583333333333333 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 12.0 0.0 1.0 0.0050655595893725 0.0143146086262432 0.0096900841078078 0.0092490490368707 0 0 0 0 K14052 0.0 0.0199430199430199 puuP; putrescine importer 438.0 9.0 0.0 1.0 1.0 E 0.0 9.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 9.0 0.0 1.0 0.0166900693783006 0.0428623723964549 0.0297762208873777 0.0261723030181543 0 0 0 0 K14053 0.0 0.0028490028490028 ompG; outer membrane protein G 301.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 28K0Z 1.0 0.0 1.0 0 0 0 0 K14054 0.0142857142857142 0.0655270655270655 mpaA; murein peptide amidase A 113.0 34.0 32.0 2.0 0.944444444444444 E 9.0 27.0 1.0 1.0 COG2866 Murein_tripeptide_amidase_MpaA MpaA 36.0 0.25 0.75 0.0399438433833164 0.374663118483875 0.2073034809335957 0.3347192751005586 0 0 0 0 K14055 0.0 0.037037037037037 uspE; universal stress protein E 268.0 16.0 0.0 1.0 1.0 T 0.0 16.0 1.0 1.0 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 16.0 0.0 1.0 0.0024428651895116 0.0060259152199995 0.0042343902047555 0.0035830500304879 0 0 0 0 K14056 0.0 0.0085470085470085 puuR; HTH-type transcriptional regulator, repressor for puuD 179.0 2.0 1.0 2.0 0.666666666666667 K 0.0 3.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 3.0 0.0 1.0 0 0 0 0 K14057 0.0 0.0085470085470085 abgR; LysR family transcriptional regulator, regulator of abg operon 298.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.0104791214732019 0.0205451536617226 0.0155121375674622 0.0100660321885207 0 0 0 0 K14058 0.0028571428571428 0.1994301994301994 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA 211.0 35.0 11.0 4.0 0.472972972972973 J 1.0 73.0 1.0 1.0 COG0037 tRNA(Ile)-lysidine_synthase_TilS/MesJ TilS 74.0 0.0135135135135135 0.9864864864864864 0.0562544422355044 0.0424620377812552 0.0493582400083798 0.0137924044542492 0 0 0 0 K14059 0.0028571428571428 0.1082621082621082 int; integrase 63.0 63.0 0.0 1.0 1.0 L 1.0 55.0 2.0 0.793650793650794 COG0582 Integrase/recombinase,_includes_phage_integrase FimB 56.0 0.0178571428571428 0.9821428571428572 0.0032215242202536 0.0292592955142533 0.0162404098672534 0.0260377712939997 0 0 0 0 K14060 0.04 0.0455840455840455 pinR; putative DNA-invertase from lambdoid prophage Rac 143.0 38.0 0.0 1.0 1.0 L 17.0 21.0 1.0 1.0 COG1961 Site-specific_DNA_recombinase_SpoIVCA/DNA_invertase_PinE SpoIVCA 38.0 0.4473684210526316 0.5526315789473685 0.0952038411249855 0.118237107865147 0.1067204744950662 0.0230332667401614 0 0 0 0 K14061 0.0 0.0227920227920227 uspF; universal stress protein F 124.0 13.0 0.0 1.0 1.0 T 0.0 13.0 1.0 1.0 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 13.0 0.0 1.0 0.0026376425163998 0.0073785762772977 0.0050081093968487 0.0047409337608978 0 0 0 0 K14062 0.0 0.0113960113960113 ompN; outer membrane protein N 254.0 15.0 0.0 1.0 1.0 M 0.0 15.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 15.0 0.0 1.0 0.0016988951013363 0.0030228566969064 0.0023608758991213 0.0013239615955701 0 0 0 0 K14063 0.0 0.0028490028490028 feaR; AraC family transcriptional regulator, positive regulator of tynA and feaB 301.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K14064 0.0 0.0085470085470085 uspC; universal stress protein C 131.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 3.0 0.0 1.0 0 0 0 0 K14065 0.0 0.0085470085470085 uspD; universal stress protein D 133.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 3.0 0.0 1.0 0 0 0 0 K14067 0.0114285714285714 0.0484330484330484 mtkA; malate-CoA ligase subunit beta [EC:6.2.1.9] path:map00630,path:map00680,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 371.0 16.0 5.0 2.0 0.592592592592593 F 4.0 23.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 27.0 0.1481481481481481 0.8518518518518519 0.672536117145682 0.90175351890022 0.787144818022951 0.229217401754538 0 1 0 1 K14068 0.0428571428571428 0.0 vhoA, vhtA; methanophenazine hydrogenase, large subunit [EC:1.12.98.3] 466.0 19.0 0.0 1.0 1.0 C 19.0 0.0 1.0 1.0 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 19.0 1.0 0.0 0.963546328125418 0.772360885004035 0.8679536065647264 0.1911854431213829 0 0 1 1 K14069 0.0485714285714285 0.0 vhoC, vhtC; methanophenazine hydrogenase, cytochrome b subunit [EC:1.12.98.3] 183.0 22.0 0.0 1.0 1.0 C 22.0 0.0 1.0 1.0 COG2864 Cytochrome_b_subunit_of_formate_dehydrogenase FdnI 22.0 1.0 0.0 0.521816772727995 0.376509791901765 0.44916328231488 0.14530698082623 0 0 0 1 K14070 0.0314285714285714 0.0 vhoG, vhtG; methanophenazine hydrogenase [EC:1.12.98.3] 357.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG1740 Ni,Fe-hydrogenase_I_small_subunit HyaA 15.0 1.0 0.0 0.308824925271893 0.53383717370117 0.4213310494865315 0.225012248429277 0 0 0 0 K14080 0.1285714285714285 0.0455840455840455 mtaA; [methyl-Co(III) methanol/glycine betaine-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.246 2.1.1.377] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 215.0 131.0 0.0 1.0 1.0 H 115.0 16.0 1.0 1.0 COG0407 Uroporphyrinogen-III_decarboxylase_HemE HemE 131.0 0.8778625954198473 0.1221374045801526 0.330257837479312 0.834181289196293 0.5822195633378024 0.503923451716981 0 0 0 0 K14081 0.0771428571428571 0.0 mtaC; methanol corrinoid protein path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 239.0 49.0 48.0 2.0 0.98 S 50.0 0.0 1.0 1.0 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 50.0 1.0 0.0 0.0035182356178528 0.007402171381071 0.0054602034994619 0.0038839357632182 0 0 0 0 K14082 0.0742857142857142 0.0 mtbA; [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.247] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 306.0 44.0 0.0 1.0 1.0 H 44.0 0.0 1.0 1.0 COG0407 Uroporphyrinogen-III_decarboxylase_HemE HemE 44.0 1.0 0.0 0.167466443876131 0.221368397808621 0.194417420842376 0.05390195393249 0 0 0 0 K14083 0.1142857142857142 0.074074074074074 mttB; trimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.250] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 212.0 179.0 0.0 1.0 1.0 H 99.0 80.0 1.0 1.0 COG5598 Trimethylamine:corrinoid_methyltransferase MttB2 179.0 0.553072625698324 0.4469273743016759 0.0141115631623788 0.0975181879266015 0.0558148755444901 0.0834066247642227 0 0 0 0 K14084 0.1171428571428571 0.0056980056980056 mttC; trimethylamine corrinoid protein path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 203.0 62.0 56.0 2.0 0.911764705882353 S 66.0 2.0 1.0 1.0 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 68.0 0.9705882352941176 0.0294117647058823 0.858818279625023 0.97179272779282 0.9153055037089216 0.112974448167797 0 0 1 1 K14085 0.0 0.0028490028490028 ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] path:map00010,path:map00053,path:map00071,path:map00260,path:map00280,path:map00310,path:map00330,path:map00340,path:map00380,path:map00410,path:map00561,path:map00620,path:map01100,path:map01110,path:map01120,path:map04936 Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid degradation,Glycine, serine and threonine metabolism,Valine, leucine and isoleucine degradation,Lysine degradation,Arginine and proline metabolism,Histidine metabolism,Tryptophan metabolism,beta-Alanine metabolism,Glycerolipid metabolism,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Alcoholic liver disease 600.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 1.0 0.0 1.0 0 0 0 0 K14086 0.04 0.0826210826210826 echA; ech hydrogenase subunit A 411.0 38.0 25.0 2.0 0.745098039215686 CP 16.0 35.0 2.0 0.980392156862745 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 51.0 0.3137254901960784 0.6862745098039216 0.0452824763144598 0.158538820754128 0.1019106485342939 0.1132563444396682 0 0 0 0 K14087 0.0371428571428571 0.0227920227920227 echB; ech hydrogenase subunit B 260.0 23.0 0.0 1.0 1.0 C 15.0 8.0 1.0 1.0 COG0650 Formate_hydrogenlyase_subunit_HyfC HyfC 23.0 0.6521739130434783 0.3478260869565217 0.02712162502715 0.0684599630862731 0.0477907940567115 0.0413383380591231 0 0 0 0 K14088 0.1142857142857142 0.0427350427350427 echC; ech hydrogenase subunit C 131.0 68.0 0.0 1.0 1.0 C 52.0 16.0 2.0 0.985294117647059 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 68.0 0.7647058823529411 0.2352941176470588 0.910752293117984 0.958795369259868 0.934773831188926 0.0480430761418839 1 1 1 1 K14089 0.0457142857142857 0.0199430199430199 echD; ech hydrogenase subunit D 79.0 24.0 0.0 1.0 1.0 C 17.0 7.0 5.0 0.458333333333333 COG0852 NADH:ubiquinone_oxidoreductase_27_kD_subunit_(chain_C) NuoC 24.0 0.7083333333333334 0.2916666666666667 0.0181879978989481 0.0249957753800666 0.0215918866395073 0.0068077774811185 0 0 0 0 K14090 0.1228571428571428 0.037037037037037 echE; ech hydrogenase subunit E 302.0 70.0 0.0 1.0 1.0 C 56.0 14.0 1.0 1.0 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 70.0 0.8 0.2 0.932819369489405 0.984262461951751 0.958540915720578 0.051443092462346 1 1 1 1 K14091 0.0628571428571428 0.0313390313390313 echF; ech hydrogenase subunit F 78.0 34.0 0.0 1.0 1.0 C 23.0 11.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 34.0 0.6764705882352942 0.3235294117647059 0.0713171004171439 0.442682288654668 0.256999694535906 0.3713651882375241 0 0 0 0 K14092 0.0257142857142857 0.0 ehaA; energy-converting hydrogenase A subunit A 80.0 9.0 0.0 1.0 1.0 S 9.0 0.0 1.0 1.0 COG4042 Energy-converting_hydrogenase_Eha_subunit_A EhaA 9.0 1.0 0.0 0.0010187199333987 0.001670824736169 0.0013447723347838 0.0006521048027702 0 0 0 0 K14093 0.0428571428571428 0.0 ehaB; energy-converting hydrogenase A subunit B 159.0 15.0 0.0 1.0 1.0 COG4041 Energy-converting_hydrogenase_Eha_subunit_B EhaB 15.0 1.0 0.0 0 0 0 0 K14094 0.0428571428571428 0.0 ehaC; energy-converting hydrogenase A subunit C 75.0 15.0 0.0 1.0 1.0 S 15.0 0.0 1.0 1.0 COG4040 Energy-converting_hydrogenase_Eha_subunit_C EhaC 15.0 1.0 0.0 0.0016372439745295 0.0023551144463936 0.0019961792104615 0.0007178704718641 0 0 0 0 K14095 0.04 0.0 ehaD; energy-converting hydrogenase A subunit D 70.0 13.0 12.0 2.0 0.928571428571429 S 14.0 0.0 2.0 0.642857142857143 COG4039 Energy-converting_hydrogenase_Eha_subunit_D EhaD 14.0 1.0 0.0 0.0010888302448746 0.0067129515191521 0.0039008908820133 0.0056241212742774 0 0 0 0 K14096 0.0428571428571428 0.0 ehaE; energy-converting hydrogenase A subunit E 79.0 15.0 0.0 1.0 1.0 S 15.0 0.0 1.0 1.0 COG4038 Energy-converting_hydrogenase_Eha_subunit_E EhaE 15.0 1.0 0.0 0.0026023535084175 0.0014855760750107 0.0020439647917141 0.0011167774334067 0 0 0 0 K14097 0.0428571428571428 0.0 ehaF; energy-converting hydrogenase A subunit F 143.0 15.0 0.0 1.0 1.0 S 15.0 0.0 1.0 1.0 COG4037 Energy-converting_hydrogenase_Eha_subunit_F EhaF 15.0 1.0 0.0 0.0011295303762656 0.0023681781487286 0.0017488542624971 0.001238647772463 0 0 0 0 K14098 0.0428571428571428 0.0 ehaG; energy-converting hydrogenase A subunit G 188.0 15.0 0.0 1.0 1.0 S 15.0 0.0 1.0 1.0 COG4036 Energy-converting_hydrogenase_Eha_subunit_G EhaG 15.0 1.0 0.0 0.0007867607308953 0.0027013756870546 0.0017440682089749 0.0019146149561593 0 0 0 0 K14099 0.0428571428571428 0.0 ehaH; energy-converting hydrogenase A subunit H 213.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG4078 Energy-converting_hydrogenase_Eha_subunit_H EhaH 15.0 1.0 0.0 0.0040342643320638 0.0071762697721292 0.0056052670520965 0.0031420054400653 0 0 0 0 K14100 0.0314285714285714 0.0 ehaI; energy-converting hydrogenase A subunit I 66.0 11.0 0.0 2.0 0.545454545454545 arCOG06464 11.0 1.0 0.0 0 0 0 0 K14101 0.0428571428571428 0.0 ehaJ; energy-converting hydrogenase A subunit J 279.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG0650 Formate_hydrogenlyase_subunit_HyfC HyfC 15.0 1.0 0.0 0.0015318341249081 0.0079322457974916 0.0047320399611998 0.0064004116725834 0 0 0 0 K14102 0.02 0.0 ehaK; energy-converting hydrogenase A subunit K 80.0 7.0 0.0 3.0 0.428571428571429 arCOG06676 7.0 1.0 0.0 0 0 0 0 K14103 0.0285714285714285 0.0 ehaL; energy-converting hydrogenase A subunit L 89.0 10.0 0.0 1.0 1.0 S 10.0 0.0 1.0 1.0 COG4035 Energy-converting_hydrogenase_Eha_subunit_L EhaL 10.0 1.0 0.0 9.50063146582359e-05 0.0001723594890849 0.0001336829018715 7.735317442666409e-05 0 0 0 0 K14104 0.04 0.0 ehaM; energy-converting hydrogenase A subunit M 120.0 14.0 0.0 1.0 1.0 S 14.0 0.0 1.0 1.0 COG4084 Energy-converting_hydrogenase_A_subunit_M EhaM 14.0 1.0 0.0 0.0009919184283864 0.0078424443597837 0.004417181394085 0.0068505259313973 0 0 0 0 K14105 0.0428571428571428 0.0056980056980056 ehaN; energy-converting hydrogenase A subunit N 144.0 17.0 0.0 1.0 1.0 C 15.0 2.0 1.0 1.0 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 17.0 0.8823529411764706 0.1176470588235294 0.0128083551790991 0.0183698928819167 0.0155891240305079 0.0055615377028176 0 0 0 0 K14106 0.0428571428571428 0.0 ehaO; energy-converting hydrogenase A subunit O 352.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 15.0 1.0 0.0 0.0027384953252337 0.0038922384578313 0.0033153668915325 0.0011537431325976 0 0 0 0 K14107 0.0428571428571428 0.0 ehaP; energy-converting hydrogenase A subunit P 174.0 17.0 0.0 1.0 1.0 C 17.0 0.0 1.0 1.0 COG1145 Ferredoxin NapF 17.0 1.0 0.0 0.0122798367594149 0.0099458534941633 0.0111128451267891 0.0023339832652515 0 0 0 0 K14108 0.0542857142857142 0.0 ehaQ; energy-converting hydrogenase A subunit Q 117.0 20.0 0.0 1.0 1.0 C 20.0 0.0 2.0 0.75 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 20.0 1.0 0.0 0.944575660224605 0.983101580901791 0.963838620563198 0.0385259206771859 0 0 1 1 K14109 0.0628571428571428 0.0 ehaR; energy-converting hydrogenase A subunit R 293.0 22.0 0.0 1.0 1.0 S 22.0 0.0 1.0 1.0 COG4030 Predicted_phosphohydrolase,_HAD_superfamily 22.0 1.0 0.0 0.0079419153553398 0.0160392097258699 0.0119905625406048 0.0080972943705301 0 0 0 0 K14110 0.0542857142857142 0.0 ehbA; energy-converting hydrogenase B subunit A 100.0 19.0 0.0 1.0 1.0 P 19.0 0.0 1.0 1.0 COG1863 Multisubunit_Na+/H+_antiporter,_MnhE_subunit MnhE 19.0 1.0 0.0 3.07608791515824e-12 2.06311373450743e-08 1.0317106716494727e-08 2.062806125715914e-08 0 0 0 0 K14111 0.0314285714285714 0.0 ehbB; energy-converting hydrogenase B subunit B 79.0 11.0 0.0 1.0 1.0 P 11.0 0.0 1.0 1.0 COG2212 Multisubunit_Na+/H+_antiporter,_MnhF_subunit MnhF 11.0 1.0 0.0 2.37126843656902e-12 8.33028689961336e-10 4.176999791989525e-10 8.30657421524767e-10 0 0 0 0 K14112 0.0342857142857142 0.0 ehbC; energy-converting hydrogenase B subunit C 86.0 12.0 0.0 1.0 1.0 P 12.0 0.0 1.0 1.0 COG1320 Multisubunit_Na+/H+_antiporter,_MnhG_subunit MnhG 12.0 1.0 0.0 0.154538207840937 0.26221367883036 0.2083759433356485 0.107675470989423 0 0 0 0 K14113 0.0485714285714285 0.0 ehbD; energy-converting hydrogenase B subunit D 77.0 17.0 0.0 1.0 1.0 P 17.0 0.0 1.0 1.0 COG1563 Uncharacterized_MnhB-related_membrane_protein 17.0 1.0 0.0 0.0637442715731773 0.16779011734499 0.1157671944590836 0.1040458457718127 0 0 0 0 K14114 0.0514285714285714 0.0 ehbE; energy-converting hydrogenase B subunit E 115.0 18.0 0.0 1.0 1.0 P 18.0 0.0 1.0 1.0 COG1006 Multisubunit_Na+/H+_antiporter,_MnhC_subunit MnhC 18.0 1.0 0.0 0.0016365789347544 0.0034839547590457 0.0025602668469 0.0018473758242913 0 0 0 0 K14115 0.0685714285714285 0.0 ehbF; energy-converting hydrogenase B subunit F 439.0 23.0 22.0 2.0 0.958333333333333 C 24.0 0.0 1.0 1.0 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 24.0 1.0 0.0 6.297499046449e-06 0.922532478722773 0.4612693881109097 0.9225261812237264 0 0 0 0 K14116 0.0285714285714285 0.0 ehbG; energy-converting hydrogenase B subunit G 93.0 10.0 0.0 1.0 1.0 arCOG05076 10.0 1.0 0.0 0 0 0 0 K14117 0.0142857142857142 0.0 ehbH; energy-converting hydrogenase B subunit H 86.0 5.0 0.0 1.0 1.0 P 5.0 0.0 1.0 1.0 COG2111 Multisubunit_Na+/H+_antiporter,_MnhB_subunit MnhB 5.0 1.0 0.0 2.13465692264518e-21 4.31244715184247e-13 2.15622358659452e-13 4.312447130495901e-13 0 0 0 0 K14118 0.0628571428571428 0.0 ehbI; energy-converting hydrogenase B subunit I 134.0 24.0 0.0 1.0 1.0 P 22.0 0.0 1.0 1.0 COG2111 Multisubunit_Na+/H+_antiporter,_MnhB_subunit MnhB 22.0 1.0 0.0 0.802305620439195 0.969226210513845 0.8857659154765201 0.1669205900746501 0 0 1 1 K14119 0.0285714285714285 0.0 ehbJ; energy-converting hydrogenase B subunit J 70.0 10.0 0.0 2.0 0.8 arCOG06490 10.0 1.0 0.0 0 0 0 0 K14120 0.0371428571428571 0.0 ehbK; energy-converting hydrogenase B subunit K 403.0 13.0 0.0 1.0 1.0 C 13.0 0.0 1.0 1.0 COG1145 Ferredoxin NapF 13.0 1.0 0.0 0.0089986956585111 0.103757008387326 0.0563778520229185 0.0947583127288149 0 0 0 0 K14121 0.0771428571428571 0.0 ehbL; energy-converting hydrogenase B subunit L 114.0 27.0 0.0 1.0 1.0 C 27.0 0.0 2.0 0.925925925925926 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 27.0 1.0 0.0 0.943813996235301 0.936565958392147 0.940189977313724 0.007248037843154 0 0 1 1 K14122 0.0485714285714285 0.0 ehbM; energy-converting hydrogenase B subunit M 146.0 17.0 0.0 1.0 1.0 C 17.0 0.0 1.0 1.0 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 17.0 1.0 0.0 0.0722960471409312 3.87646246820504e-12 0.0361480235724038 0.0722960471370547 0 0 0 0 K14123 0.0485714285714285 0.0 ehbN; energy-converting hydrogenase B subunit N 365.0 17.0 0.0 1.0 1.0 C 17.0 0.0 1.0 1.0 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 17.0 1.0 0.0 0.104960410212295 0.209967046947524 0.1574637285799095 0.1050066367352289 0 0 0 0 K14124 0.0485714285714285 0.0 ehbO; energy-converting hydrogenase B subunit O 314.0 17.0 0.0 1.0 1.0 C 17.0 0.0 1.0 1.0 COG0650 Formate_hydrogenlyase_subunit_HyfC HyfC 17.0 1.0 0.0 0.103030975934376 0.212986675344669 0.1580088256395225 0.109955699410293 0 0 0 0 K14125 0.0485714285714285 0.0 ehbP; energy-converting hydrogenase B subunit P 79.0 17.0 0.0 1.0 1.0 C 17.0 0.0 1.0 1.0 arCOG04876 17.0 1.0 0.0 0.098236586626613 0.198209780642608 0.1482231836346105 0.099973194015995 0 0 0 0 K14126 0.2571428571428571 0.0854700854700854 mvhA, vhuA, vhcA; F420-non-reducing hydrogenase large subunit [EC:1.12.99.- 1.8.98.5] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 309.0 154.0 0.0 1.0 1.0 C 119.0 35.0 2.0 0.577922077922078 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 154.0 0.7727272727272727 0.2272727272727272 0.918841683756964 0.982715999991974 0.9507788418744688 0.06387431623501 1 1 1 1 K14127 0.2514285714285714 0.0683760683760683 mvhD, vhuD, vhcD; F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 124.0 210.0 0.0 1.0 1.0 C 156.0 54.0 4.0 0.933333333333333 COG1908 Coenzyme_F420-reducing_hydrogenase,_delta_subunit FrhD 210.0 0.7428571428571429 0.2571428571428571 0.971972860378615 0.963754138478827 0.967863499428721 0.008218721899788 1 1 1 1 K14128 0.2542857142857143 0.094017094017094 mvhG, vhuG, vhcG; F420-non-reducing hydrogenase small subunit [EC:1.12.99.- 1.8.98.5] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 176.0 169.0 0.0 1.0 1.0 C 120.0 41.0 2.0 0.928994082840237 COG1941 Coenzyme_F420-reducing_hydrogenase,_gamma_subunit FrhG 161.0 0.7453416149068323 0.2546583850931677 0.931814851976437 0.977018046870824 0.9544164494236304 0.045203194894387 1 1 1 1 K14136 0.0 0.0341880341880341 K14136; decaprenyl-phosphate phosphoribosyltransferase [EC:2.4.2.45] 292.0 12.0 0.0 1.0 1.0 H 0.0 12.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 12.0 0.0 1.0 1.06961706578717e-05 0.0053179545509252 0.0026643253607915 0.0053072583802673 0 0 0 0 K14138 0.0171428571428571 0.0712250712250712 acsB; acetyl-CoA synthase [EC:2.3.1.169] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 504.0 34.0 0.0 1.0 1.0 C 6.0 28.0 3.0 0.911764705882353 COG1614 CO_dehydrogenase/acetyl-CoA_synthase_beta_subunit CdhC 34.0 0.1764705882352941 0.8235294117647058 0.0150438268705636 0.752352862655599 0.3836983447630813 0.7373090357850354 0 0 0 0 K14152 0.0 0.0056980056980056 HIS4; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase [EC:3.6.1.31 3.5.4.19 1.1.1.23] path:map00340,path:map01100,path:map01110,path:map01230 Histidine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 102.0 2.0 0.0 1.0 1.0 E 0.0 2.0 2.0 0.5 COG0139 Phosphoribosyl-AMP_cyclohydrolase HisI1 2.0 0.0 1.0 0 0 0 0 K14153 0.0142857142857142 0.1965811965811965 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 180.0 79.0 77.0 3.0 0.963414634146341 H 5.0 72.0 3.0 0.865853658536585 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine_kinase ThiD 77.0 0.0649350649350649 0.935064935064935 0.0754661073229784 0.375722027902323 0.2255940676126507 0.3002559205793446 0 0 0 0 K14155 0.02 0.3361823361823361 patB, malY; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] path:map00270,path:map00450,path:map01100,path:map01110,path:map01230 Cysteine and methionine metabolism,Selenocompound metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 262.0 153.0 147.0 4.0 0.950310559006211 E 9.0 152.0 3.0 0.950310559006211 COG1168 Bifunctional_PLP-dependent_enzyme_with_beta-cystathionase_and_maltose_regulon_repressor_activities MalY 161.0 0.0559006211180124 0.9440993788819876 0.276415915120741 0.779121328940101 0.527768622030421 0.5027054138193601 0 0 0 0 K14157 0.0285714285714285 0.0113960113960113 AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9] path:map00310,path:map01100,path:map01110 Lysine degradation,Metabolic pathways,Biosynthesis of secondary metabolites 428.0 16.0 0.0 1.0 1.0 E 11.0 5.0 1.0 1.0 COG0686 Alanine_dehydrogenase_(includes_sporulation_protein_SpoVN) Ald 16.0 0.6875 0.3125 0.134506251857291 0.834020490605017 0.484263371231154 0.699514238747726 0 0 0 0 K14159 0.0028571428571428 0.0227920227920227 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7] path:map03030,path:map03430,path:map03440 DNA replication,Mismatch repair,Homologous recombination 219.0 9.0 0.0 1.0 1.0 L 1.0 8.0 1.0 1.0 COG0847 DNA_polymerase_III,_epsilon_subunit_or_related_3'-5'_exonuclease DnaQ 9.0 0.1111111111111111 0.8888888888888888 0.0134965531173888 0.0224057486611981 0.0179511508892934 0.0089091955438093 0 0 0 0 K14160 0.0 0.0997150997150997 imuA; protein ImuA 128.0 32.0 28.0 2.0 0.888888888888889 S 0.0 36.0 2.0 0.944444444444444 COG4544 Uncharacterized_conserved_protein 36.0 0.0 1.0 0.0063507268466442 0.0194407408228018 0.012895733834723 0.0130900139761576 0 0 0 0 K14161 0.0 0.1851851851851851 imuB; protein ImuB 233.0 69.0 0.0 1.0 1.0 L 0.0 69.0 1.0 1.0 COG0389 Nucleotidyltransferase/DNA_polymerase_DinP_involved_in_DNA_repair DinP 69.0 0.0 1.0 0.0068737541079824 0.0895065235457124 0.0481901388268473 0.08263276943773 0 0 0 0 K14162 0.0057142857142857 0.3504273504273504 dnaE2; error-prone DNA polymerase [EC:2.7.7.7] 629.0 142.0 0.0 1.0 1.0 L 2.0 140.0 1.0 1.0 COG0587 DNA_polymerase_III,_alpha_subunit DnaE 142.0 0.0140845070422535 0.9859154929577464 0.0620113808642979 0.994032982049868 0.5280221814570829 0.93202160118557 0 0 0 0 K14163 0.0028571428571428 0.0 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15] path:map00860,path:map00970,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Aminoacyl-tRNA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 467.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0008 Glutamyl-_or_glutaminyl-tRNA_synthetase GlnS 1.0 1.0 0.0 0 0 0 0 K14164 0.0 0.0 glyQS; glycyl-tRNA synthetase [EC:6.1.1.14] path:map00970 Aminoacyl-tRNA biosynthesis 30.0 0.0 1.0 1.0 J 0.0 0.0 2.0 0.733333333333333 COG0751 Glycyl-tRNA_synthetase,_beta_subunit GlyS 0.0 0 0 0 0 K14165 0.1314285714285714 0.0284900284900284 K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48] 50.0 61.0 55.0 4.0 0.884057971014493 T 56.0 13.0 2.0 0.971014492753623 COG2453 Protein-tyrosine_phosphatase CDC14 69.0 0.8115942028985508 0.1884057971014492 0.294018345915044 0.170738804816809 0.2323785753659265 0.123279541098235 0 0 0 0 K14166 0.1 0.0968660968660968 ycnJ; copper transport protein 68.0 52.0 36.0 5.0 0.590909090909091 P 39.0 48.0 8.0 0.295454545454545 COG1276 Putative_copper_export_protein PcoD 87.0 0.4482758620689655 0.5517241379310345 0.0128961493652554 0.540925807184855 0.2769109782750552 0.5280296578195995 0 0 0 0 K14170 0.1714285714285714 0.4245014245014245 pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51] path:map00400,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 169.0 232.0 0.0 1.0 1.0 E 68.0 157.0 4.0 0.883620689655172 COG0077 Prephenate_dehydratase PheA2 225.0 0.3022222222222222 0.6977777777777778 0.130167213217172 0.926078613103535 0.5281229131603535 0.795911399886363 0 0 0 0 K14187 0.1057142857142857 0.1111111111111111 tyrA; chorismate mutase / prephenate dehydrogenase [EC:5.4.99.5 1.3.1.12] path:map00400,path:map00401,path:map01100,path:map01110,path:map01230 Phenylalanine, tyrosine and tryptophan biosynthesis,Novobiocin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 68.0 91.0 88.0 2.0 0.968085106382979 E 38.0 44.0 4.0 0.372340425531915 COG0287 Prephenate_dehydrogenase TyrA 82.0 0.4634146341463415 0.5365853658536586 0.645105722262353 0.717571912019266 0.6813388171408095 0.0724661897569129 0 1 0 1 K14188 0.0 0.0341880341880341 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] path:map00470,path:map00552,path:map01100,path:map01503,path:map02020,path:map05150 D-Amino acid metabolism,Teichoic acid biosynthesis,Metabolic pathways,Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Staphylococcus aureus infection 76.0 9.0 7.0 3.0 0.75 IQ 0.0 12.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 12.0 0.0 1.0 0.0138414591762481 0.0514930078232526 0.0326672334997503 0.0376515486470045 0 0 0 0 K14189 0.0 0.0569800569800569 dltE; uncharacterized oxidoreductase [EC:1.-.-.-] 203.0 33.0 0.0 1.0 1.0 M 0.0 33.0 1.0 1.0 COG3967 Short-chain_dehydrogenase_involved_in_D-alanine_esterification_of_teichoic_acids DltE 33.0 0.0 1.0 0.0240694306400458 0.0471808615334627 0.0356251460867542 0.0231114308934169 0 0 0 0 K14191 0.0028571428571428 0.0 DIM1; 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase [EC:2.1.1.183] 277.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 COG0030 16S_rRNA_A1518_and_A1519_N6-dimethyltransferase_RsmA/KsgA/DIM1_(may_also_have_DNA_glycosylase/AP_lyase_activity) RsmA 1.0 1.0 0.0 0 0 0 0 K14192 0.0 0.0028490028490028 clfB; clumping factor B path:map05150 Staphylococcus aureus infection 1130.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG4932 Clumping_factor_A-related_surface_protein,_MSCRAMM_(microbial_surface_components_recognizing_adhesive_matrix_molecules)_family,_DEv-IgG_fold ClfA 1.0 0.0 1.0 0 0 0 0 K14194 0.0057142857142857 0.0341880341880341 sdrC_D_E; serine-aspartate repeat-containing protein C/D/E path:map05150 Staphylococcus aureus infection 109.0 9.0 7.0 4.0 0.6 M 2.0 13.0 6.0 0.333333333333333 COG1404 Serine_protease,_subtilisin_family AprE 15.0 0.1333333333333333 0.8666666666666667 0.0324219269415383 0.0764159138742647 0.0544189204079015 0.0439939869327264 0 0 0 0 K14195 0.0 0.0028490028490028 sasG; surface protein G path:map05150 Staphylococcus aureus infection 839.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG3266 Cell_division_protein_DamX,_binds_to_the_septal_ring,_contains_C-terminal_SPOR_domain DamX 1.0 0.0 1.0 0 0 0 0 K14197 0.0 0.0028490028490028 sbi; immunoglobulin G-binding protein Sbi path:map05150 Staphylococcus aureus infection 283.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG1388 LysM_repeat LysM 1.0 0.0 1.0 0 0 0 0 K14198 0.0 0.0028490028490028 sak; staphylokinase path:map01503,path:map05150 Cationic antimicrobial peptide (CAMP) resistance,Staphylococcus aureus infection 167.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 2DWHZ 1.0 0.0 1.0 0 0 0 0 K14201 0.0 0.0227920227920227 clfA; clumping factor A path:map05150 Staphylococcus aureus infection 117.0 2.0 0.0 1.0 1.0 G 0.0 8.0 2.0 0.75 2E42E 8.0 0.0 1.0 0.0132253417891702 0.0399682881452792 0.0265968149672247 0.026742946356109 0 0 0 0 K14205 0.0142857142857142 0.1225071225071225 mprF, fmtC; phosphatidylglycerol lysyltransferase [EC:2.3.2.3] path:map01503,path:map02020,path:map05150 Cationic antimicrobial peptide (CAMP) resistance,Two-component system,Staphylococcus aureus infection 156.0 49.0 38.0 6.0 0.720588235294118 S 6.0 52.0 3.0 0.573529411764706 COG0392 Predicted_membrane_flippase_AglD2/YbhN,_UPF0104_family AglD2 58.0 0.1034482758620689 0.896551724137931 0.0110975278242687 0.338741634877327 0.1749195813507978 0.3276441070530583 0 0 0 0 K14208 0.0028571428571428 0.0 XPNPEP2; Xaa-Pro aminopeptidase 2 [EC:3.4.11.9] path:map04974 Protein digestion and absorption 543.0 1.0 0.0 1.0 1.0 E 1.0 0.0 1.0 1.0 COG0006 Xaa-Pro_aminopeptidase PepP 1.0 1.0 0.0 0 0 0 0 K14215 0.0 0.0968660968660968 E2.5.1.86; trans,polycis-decaprenyl diphosphate synthase [EC:2.5.1.86] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 248.0 28.0 22.0 2.0 0.823529411764706 I 0.0 34.0 1.0 1.0 COG0020 Undecaprenyl_pyrophosphate_synthase UppS 34.0 0.0 1.0 0.0010231985251763 0.0043014946468553 0.0026623465860157 0.0032782961216789 0 0 0 0 K14250 0.0 0.0056980056980056 oxyN, snoaM, dpsY, aknW, mtmY; cyclase path:map00253,path:map01057,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 252.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG1878 Kynurenine_formamidase 2.0 0.0 1.0 0 0 0 0 K14251 0.0 0.0085470085470085 oxyF; C-methyltransferase [EC:2.1.1.-] path:map00253,path:map01057,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 179.0 2.0 1.0 2.0 0.666666666666667 FG 0.0 3.0 1.0 1.0 COG4106 Trans-aconitate_methyltransferase Tam 3.0 0.0 1.0 0 0 0 0 K14252 0.0 0.0028490028490028 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233] path:map00253,path:map01057,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 662.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K14257 0.02 0.037037037037037 ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-] path:map00253,path:map00404,path:map01057,path:map01100,path:map01110 Tetracycline biosynthesis,Staurosporine biosynthesis,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 228.0 19.0 16.0 2.0 0.863636363636364 C 7.0 15.0 2.0 0.863636363636364 COG0644 Dehydrogenase_(flavoprotein) FixC 22.0 0.3181818181818182 0.6818181818181818 0.202943296489219 0.826487970760504 0.5147156336248615 0.6235446742712849 0 0 0 0 K14259 0.0657142857142857 0.0769230769230769 kdaD, xacE, kdxD; 2-dehydro-3-deoxy-D-arabinonate dehydratase [EC:4.2.1.141] path:map00040,path:map00053,path:map01100 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Metabolic pathways 224.0 47.0 42.0 4.0 0.824561403508772 S 29.0 28.0 2.0 0.964912280701754 COG3970 Fumarylacetoacetate_(FAA)_hydrolase_family_protein 57.0 0.5087719298245614 0.4912280701754385 0.0095473523380234 0.386557351300833 0.1980523518194282 0.3770099989628096 0 0 0 0 K14260 0.0142857142857142 0.1965811965811965 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] path:map00220,path:map00250,path:map00290,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Valine, leucine and isoleucine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 322.0 88.0 87.0 2.0 0.98876404494382 E 5.0 84.0 2.0 0.98876404494382 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 89.0 0.0561797752808988 0.9438202247191012 0.0021951484672317 0.0050485950165467 0.0036218717418892 0.002853446549315 0 0 0 0 K14261 0.0028571428571428 0.2905982905982906 alaC; alanine-synthesizing transaminase [EC:2.6.1.-] 347.0 106.0 99.0 2.0 0.938053097345133 E 1.0 112.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 113.0 0.0088495575221238 0.991150442477876 0.0100162362419722 0.0066233736672927 0.0083198049546324 0.0033928625746795 0 0 0 0 K14266 0.0085714285714285 0.0598290598290598 prnA, rebH, ktzQ; tryptophan 7-halogenase [EC:1.14.19.9] path:map00404,path:map01100,path:map01110 Staurosporine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 169.0 16.0 6.0 6.0 0.41025641025641 E 3.0 36.0 5.0 0.41025641025641 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 39.0 0.0769230769230769 0.9230769230769232 0.0151117956110947 0.080533819237442 0.0478228074242683 0.0654220236263473 0 0 0 0 K14267 0.0028571428571428 0.1994301994301994 dapC; N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17] path:map00300,path:map01100,path:map01120,path:map01230 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of amino acids 262.0 91.0 89.0 2.0 0.978494623655914 E 1.0 92.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 93.0 0.010752688172043 0.989247311827957 0.0077911361190226 0.014907991235353 0.0113495636771877 0.0071168551163304 0 0 0 0 K14268 0.0 0.0056980056980056 davT, gabT; 5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.48 2.6.1.19] path:map00250,path:map00310,path:map00650,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,Lysine degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 417.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 2.0 0.0 1.0 0 0 0 0 K14273 0.0771428571428571 0.0028490028490028 xdh; D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) [EC:1.1.1.179] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 285.0 69.0 68.0 2.0 0.985714285714286 S 69.0 1.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 70.0 0.9857142857142858 0.0142857142857142 0.006620083312226 0.0180243221477875 0.0123222027300067 0.0114042388355614 0 0 0 0 K14274 0.0828571428571428 0.2165242165242165 xylC; xylono-1,5-lactonase [EC:3.1.1.110] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 26.0 141.0 137.0 7.0 0.909677419354839 G 37.0 117.0 9.0 0.838709677419355 COG3386 Sugar_lactone_lactonase_YvrE YvrE 154.0 0.2402597402597402 0.7597402597402597 0.0231160048558711 0.453290672761774 0.2382033388088225 0.4301746679059028 0 0 0 0 K14275 0.1057142857142857 0.0 xad; D-xylonate dehydratase [EC:4.2.1.82] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 406.0 55.0 0.0 1.0 1.0 M 55.0 0.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 55.0 1.0 0.0 0.0029270409488765 0.0089428556146047 0.0059349482817406 0.0060158146657281 0 0 0 0 K14286 0.0 0.0028490028490028 AGXT2L1, ETNPPL; ethanolamine-phosphate phospho-lyase [EC:4.2.3.2] path:map00564,path:map01100 Glycerophospholipid metabolism,Metabolic pathways 429.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 1.0 0.0 1.0 0 0 0 0 K14287 0.0057142857142857 0.0968660968660968 ybdL; methionine transaminase [EC:2.6.1.88] 339.0 37.0 0.0 1.0 1.0 E 2.0 35.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 37.0 0.054054054054054 0.945945945945946 0.0177968045055108 0.0835585628631532 0.050677683684332 0.0657617583576424 0 0 0 0 K14292 0.0028571428571428 0.0085470085470085 TGS1; trimethylguanosine synthase [EC:2.1.1.-] 186.0 4.0 0.0 1.0 1.0 J 1.0 3.0 2.0 0.75 COG1092 23S_rRNA_G2069_N7-methylase_RlmK_or_C1962_C5-methylase_RlmI RlmK 4.0 0.25 0.75 0.359087870908157 0.426183905846676 0.3926358883774165 0.0670960349385189 0 0 0 0 K14303 0.0057142857142857 0.0 NUP160, NUP120; nuclear pore complex protein Nup160 path:map03013,path:map05014 Nucleocytoplasmic transport,Amyotrophic lateral sclerosis 182.0 2.0 0.0 1.0 1.0 L 2.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 2.0 1.0 0.0 0 0 0 0 K14326 0.0342857142857142 0.0 UPF1, RENT1; regulator of nonsense transcripts 1 [EC:3.6.4.13 5.6.2.3] path:map03013,path:map03015 Nucleocytoplasmic transport,mRNA surveillance pathway 630.0 12.0 11.0 2.0 0.923076923076923 L 13.0 0.0 1.0 1.0 COG1112 Superfamily_I_DNA_and/or_RNA_helicase DNA2 13.0 1.0 0.0 4.62714781847848e-16 6.983180496743711e-21 2.313608825141724e-16 4.627077986673512e-16 0 0 0 0 K14330 0.0 0.0427350427350427 K14330; fatty aldehyde-generating acyl-ACP reductase [EC:1.2.1.80] 338.0 13.0 11.0 2.0 0.866666666666667 S 0.0 15.0 1.0 1.0 COG5322 Predicted_amino_acid_dehydrogenase 15.0 0.0 1.0 0.0008077243792875 0.00033658944582 0.0005721569125537 0.0004711349334674 0 0 0 0 K14331 0.0 0.0512820512820512 K14331; fatty aldehyde decarbonylase [EC:4.1.99.5] 178.0 18.0 17.0 2.0 0.947368421052632 S 0.0 19.0 2.0 0.842105263157895 COG1633 Rubrerythrin,_includes_spore_coat_protein_YhjR YhjR 19.0 0.0 1.0 0.0134099911141719 0.0333929760560002 0.023401483585086 0.0199829849418283 0 0 0 0 K14333 0.0 0.0398860398860398 DHBD; 2,3-dihydroxybenzoate decarboxylase [EC:4.1.1.46] path:map00362,path:map00627,path:map01120 Benzoate degradation,Aminobenzoate degradation,Microbial metabolism in diverse environments 260.0 12.0 8.0 2.0 0.75 S 0.0 16.0 1.0 1.0 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 16.0 0.0 1.0 0.0382782720901777 0.112615574555516 0.0754469233228468 0.0743373024653383 0 0 0 0 K14335 0.0 0.0541310541310541 pimC; alpha-1,6-mannosyltransferase [EC:2.4.1.-] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 338.0 20.0 0.0 1.0 1.0 M 0.0 20.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 20.0 0.0 1.0 0.0131035350794024 0.0138417585450873 0.0134726468122448 0.0007382234656849 0 0 0 0 K14337 0.0 0.0541310541310541 mptA; alpha-1,6-mannosyltransferase [EC:2.4.1.-] path:map00571 Lipoarabinomannan (LAM) biosynthesis 319.0 20.0 0.0 1.0 1.0 S 0.0 30.0 5.0 0.666666666666667 2DBIT 30.0 0.0 1.0 0.0018848025940576 0.868853172230377 0.4353689874122173 0.8669683696363193 0 0 0 0 K14338 0.0 0.0227920227920227 cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4] path:map00071,path:map00380,path:map00627,path:map01120 Fatty acid degradation,Tryptophan metabolism,Aminobenzoate degradation,Microbial metabolism in diverse environments 282.0 7.0 6.0 2.0 0.875 C 0.0 8.0 2.0 0.875 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 8.0 0.0 1.0 0.0784829555604425 0.130617952874044 0.1045504542172432 0.0521349973136015 0 0 0 0 K14339 0.0 0.0455840455840455 mptB; alpha-1,6-mannosyltransferase [EC:2.4.1.-] path:map00571 Lipoarabinomannan (LAM) biosynthesis 349.0 21.0 0.0 1.0 1.0 S 0.0 28.0 4.0 0.714285714285714 2DBIT 28.0 0.0 1.0 0.0005044846460337 0.0134968845702479 0.0070006846081408 0.0129923999242142 0 0 0 0 K14340 0.0 0.0712250712250712 K14340; mannosyltransferase [EC:2.4.1.-] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 184.0 21.0 12.0 2.0 0.7 M 0.0 32.0 2.0 0.65625 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 32.0 0.0 1.0 0.0264051494688538 0.683081802178159 0.3547434758235063 0.6566766527093052 0 0 0 0 K14347 0.0085714285714285 0.1452991452991453 SLC10A7, P7; solute carrier family 10 (sodium/bile acid cotransporter), member 7 238.0 58.0 0.0 1.0 1.0 S 4.0 54.0 1.0 1.0 COG0385 Predicted_Na+-dependent_transporter_YfeH YfeH 58.0 0.0689655172413793 0.9310344827586208 0.0195022409215465 0.0589543149292381 0.0392282779253922 0.0394520740076916 0 0 0 0 K14348 0.0 0.0256410256410256 lldR; GntR family transcriptional regulator, L-lactate dehydrogenase operon regulator 223.0 11.0 0.0 1.0 1.0 K 0.0 11.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 11.0 0.0 1.0 0.0086967040368772 0.0260921883410641 0.0173944461889706 0.0173954843041869 0 0 0 0 K14358 0.0171428571428571 0.0085470085470085 SCRN; secernin 363.0 9.0 0.0 1.0 1.0 E 6.0 3.0 1.0 1.0 COG4690 Dipeptidase PepD 9.0 0.6666666666666666 0.3333333333333333 0.672252484440685 0.0350325487977747 0.3536425166192298 0.6372199356429102 0 0 0 1 K14367 0.0 0.0028490028490028 eryBV; erythronolide mycarosyltransferase [EC:2.4.1.328] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 412.0 2.0 0.0 1.0 1.0 CG 0.0 2.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 2.0 0.0 1.0 0 0 0 0 K14368 0.0 0.0028490028490028 eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 424.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K14369 0.0 0.0056980056980056 eryG; erythromycin 3''-O-methyltransferase [EC:2.1.1.254] path:map00522,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 238.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 2.0 0.0 1.0 0 0 0 0 K14370 0.0 0.0028490028490028 eryK, CYP113A; erythromycin 12 hydroxylase [EC:1.14.13.154] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 388.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K14371 0.0 0.0028490028490028 aveA1; avermectin polyketide synthase AveA1 path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 1634.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 3.0 0.0 1.0 0 0 0 0 K14372 0.0 0.0028490028490028 aveE, CYP171A; cytochrome P450 hydroxylase [EC:1.14.-.-] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 443.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K14374 0.0028571428571428 0.0056980056980056 aveD; avermectin B 5-O-methyltransferase [EC:2.1.1.-] path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 177.0 3.0 0.0 1.0 1.0 Q 1.0 2.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K14379 0.0 0.0427350427350427 ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2] path:map00740,path:map01100,path:map04142,path:map04380,path:map05323 Riboflavin metabolism,Metabolic pathways,Lysosome,Osteoclast differentiation,Rheumatoid arthritis 230.0 15.0 14.0 2.0 0.9375 S 0.0 16.0 1.0 1.0 COG1409 3',5'-cyclic_AMP_phosphodiesterase_CpdA CpdA 16.0 0.0 1.0 0.0417523231650307 0.444280256584509 0.2430162898747698 0.4025279334194783 0 0 0 0 K14387 0.0114285714285714 0.0313390313390313 SLC5A7, CHT1; solute carrier family 5 (high affinity choline transporter), member 7 path:map04725,path:map05231 Cholinergic synapse,Choline metabolism in cancer 411.0 15.0 0.0 1.0 1.0 E 4.0 11.0 1.0 1.0 COG0591 Na+/proline_symporter PutP 15.0 0.2666666666666666 0.7333333333333333 0.11832776700449 0.273166571028119 0.1957471690163044 0.1548388040236289 0 0 0 0 K14392 0.0485714285714285 0.074074074074074 panF; sodium/pantothenate symporter 378.0 33.0 13.0 2.0 0.622641509433962 H 26.0 27.0 2.0 0.641509433962264 COG0591 Na+/proline_symporter PutP 53.0 0.490566037735849 0.5094339622641509 0.0281549035818671 0.335662547162574 0.1819087253722205 0.3075076435807068 0 0 0 0 K14393 0.1114285714285714 0.3418803418803419 actP; cation/acetate symporter 370.0 209.0 205.0 5.0 0.954337899543379 S 42.0 177.0 5.0 0.954337899543379 COG4147 Na+(or_H+)/acetate_symporter_ActP ActP 219.0 0.1917808219178082 0.8082191780821918 0.0449792715898035 0.104534454335163 0.0747568629624832 0.0595551827453594 0 0 0 0 K14414 0.0 0.037037037037037 rtcR; transcriptional regulatory protein RtcR 517.0 10.0 7.0 2.0 0.769230769230769 K 0.0 13.0 1.0 1.0 COG4650 Sigma54-dependent_transcription_regulator_containing_an_AAA-type_ATPase_domain_and_a_DNA-binding_domain RtcR 13.0 0.0 1.0 0.0419418255930887 0.103887050352233 0.0729144379726608 0.0619452247591443 0 0 0 0 K14415 0.8971428571428571 0.3931623931623931 RTCB, rtcB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8] 229.0 240.0 44.0 5.0 0.47244094488189 S 339.0 169.0 6.0 0.90748031496063 COG1690 RNA-splicing_ligase_RtcB,_repairs_tRNA_damage RtcB 508.0 0.6673228346456693 0.3326771653543307 0.1319387146398 0.824742268829822 0.478340491734811 0.692803554190022 0 0 0 0 K14416 0.0028571428571428 0.0 HBS1; elongation factor 1 alpha-like protein path:map03015,path:map05134 mRNA surveillance pathway,Legionellosis 182.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG5256 Translation_elongation_factor_EF-1alpha_(GTPase) TEF1 1.0 1.0 0.0 0 0 0 0 K14440 0.0028571428571428 0.0028490028490028 SMARCAL1, HARP; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 [EC:5.6.2.-] 495.0 1.0 0.0 2.0 0.5 B 1.0 1.0 1.0 1.0 COG0553 Superfamily_II_DNA_or_RNA_helicase,_SNF2_family HepA 2.0 0.5 0.5 0 0 0 0 K14441 0.0028571428571428 0.6524216524216524 rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] 271.0 197.0 161.0 2.0 0.84549356223176 J 1.0 232.0 1.0 1.0 COG0621 tRNA_A37_methylthiotransferase_MiaB MiaB 233.0 0.0042918454935622 0.9957081545064378 0.0550274943756036 0.146343480099185 0.1006854872373942 0.0913159857235813 0 0 0 0 K14442 0.0028571428571428 0.0 DHX36, RHAU; ATP-dependent RNA helicase DHX36 [EC:3.6.4.13] path:map03018 RNA degradation 418.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0124 Histidyl-tRNA_synthetase HisS 1.0 1.0 0.0 0 0 0 0 K14445 0.1771428571428571 0.2735042735042735 SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 292.0 202.0 0.0 1.0 1.0 P 72.0 130.0 2.0 0.767326732673267 COG0471 Di-_and_tricarboxylate_antiporter CitT 202.0 0.3564356435643564 0.6435643564356436 0.775710422573031 0.960048740162536 0.8678795813677835 0.184338317589505 1 1 1 1 K14446 0.0 0.0655270655270655 ccr; crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 172.0 19.0 15.0 3.0 0.76 C 0.0 25.0 2.0 0.84 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 25.0 0.0 1.0 0.0821296855376316 0.564221690648298 0.3231756880929647 0.4820920051106663 0 0 0 0 K14447 0.0 0.0997150997150997 ecm; ethylmalonyl-CoA mutase [EC:5.4.99.63] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 287.0 32.0 22.0 3.0 0.744186046511628 I 0.0 41.0 3.0 0.465116279069767 COG1884 Methylmalonyl-CoA_mutase,_N-terminal_domain/subunit Sbm 41.0 0.0 1.0 0.0061693823461629 0.0990453787384664 0.0526073805423146 0.0928759963923035 0 0 0 0 K14448 0.0 0.0655270655270655 mcd; (2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 381.0 14.0 4.0 2.0 0.583333333333333 I 0.0 24.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 24.0 0.0 1.0 0.0028444050807816 0.0096313380352648 0.0062378715580231 0.0067869329544832 0 0 0 0 K14449 0.0685714285714285 0.0626780626780626 mch, mcd; 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] path:map00630,path:map00660,path:map00720,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 146.0 42.0 36.0 2.0 0.875 I 26.0 22.0 2.0 0.854166666666667 COG2030 Acyl-CoA_dehydratase_PaaZ MaoC 48.0 0.5416666666666666 0.4583333333333333 0.0050427382682469 0.23479837217321 0.1199205552207284 0.2297556339049631 0 0 0 0 K14451 0.0 0.037037037037037 mcl2; (3S)-malyl-CoA thioesterase [EC:3.1.2.30] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 282.0 11.0 9.0 2.0 0.846153846153846 G 0.0 13.0 1.0 1.0 COG2301 Citrate_lyase_beta_subunit CitE 13.0 0.0 1.0 0.0087540201345281 0.0137660225064864 0.0112600213205072 0.0050120023719583 0 0 0 0 K14459 0.0028571428571428 0.0 HEX; hexosaminidase [EC:3.2.1.52] path:map00511,path:map00513,path:map01100 Other glycan degradation,Various types of N-glycan biosynthesis,Metabolic pathways 600.0 1.0 0.0 1.0 1.0 G 1.0 0.0 1.0 1.0 COG3525 N-acetyl-beta-hexosaminidase Chb 1.0 1.0 0.0 0 0 0 0 K14465 0.0285714285714285 0.0 K14465; succinate semialdehyde reductase (NADPH) [EC:1.1.1.-] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 356.0 10.0 0.0 1.0 1.0 C 10.0 0.0 1.0 1.0 COG1062 Zn-dependent_alcohol/formaldehyde_dehydrogenase FrmA 10.0 1.0 0.0 2.85117058609824e-12 4.17856597053821e-12 3.514868278318225e-12 1.3273953844399699e-12 0 0 0 0 K14466 0.0 0.0 K14466; 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 14.0 0.0 1.0 1.0 I 0.0 0.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 0.0 0 0 0 0 K14467 0.0171428571428571 0.0 4hbl; 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 601.0 8.0 0.0 1.0 1.0 I 8.0 0.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 8.0 1.0 0.0 4.8465914924489e-13 3.11476114181891e-05 1.5573805951424124e-05 3.114761093352995e-05 0 0 0 0 K14468 0.0 0.0028490028490028 mcr; malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298] path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 1225.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K14469 0.0 0.0142450142450142 K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 273.0 3.0 2.0 3.0 0.6 C 0.0 5.0 3.0 0.6 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 5.0 0.0 1.0 0.0373047101044217 0.067776543318332 0.0525406267113768 0.0304718332139102 0 0 0 0 K14470 0.0 0.0341880341880341 mct; 2-methylfumaryl-CoA isomerase [EC:5.4.1.3] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 397.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 12.0 0.0 1.0 0.0513291764283736 0.219326825792319 0.1353280011103463 0.1679976493639454 0 0 0 0 K14471 0.0 0.0056980056980056 smtA1; succinyl-CoA:(S)-malate CoA-transferase subunit A [EC:2.8.3.22] path:map00660,path:map00720,path:map01100,path:map01120,path:map01200 C5-Branched dibasic acid metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 384.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 2.0 0.0 1.0 0 0 0 0 K14472 0.0 0.0056980056980056 smtB; succinyl-CoA:(S)-malate CoA-transferase subunit B [EC:2.8.3.22] path:map00660,path:map00720,path:map01100,path:map01120,path:map01200 C5-Branched dibasic acid metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 383.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 2.0 0.0 1.0 0 0 0 0 K14475 0.1685714285714285 0.0911680911680911 ICP; inhibitor of cysteine peptidase path:map05143 African trypanosomiasis 15.0 54.0 21.0 7.0 0.435483870967742 S 86.0 38.0 9.0 0.624 COG5513 Chagasin-like_inhibitor_of_cysteine_peptidase,_I42_family ICP 124.0 0.6935483870967742 0.3064516129032258 0.0641630303510675 0.0825418041818427 0.0733524172664551 0.0183787738307752 0 0 0 0 K14481 0.0 0.0056980056980056 styA; styrene monooxygenase [EC:1.14.14.11] path:map00643,path:map01100,path:map01120 Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 396.0 2.0 0.0 1.0 1.0 CH 0.0 2.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 2.0 0.0 1.0 0 0 0 0 K14482 0.0 0.0028490028490028 styB; styrene monooxygenase reductase component [EC:1.5.1.-] path:map00643,path:map01100,path:map01120 Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 158.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 1.0 0.0 1.0 0 0 0 0 K14492 0.0 0.0028490028490028 ARR-A; two-component response regulator ARR-A family path:map04075 Plant hormone signal transduction 126.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG5641 1.0 0.0 1.0 0 0 0 0 K14518 0.0 0.037037037037037 pipX; PII interaction protein X 87.0 14.0 0.0 1.0 1.0 S 0.0 14.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 14.0 0.0 1.0 0.0004780062019913 4.45015265950305e-05 0.0002612538642931 0.0004335046753962 0 0 0 0 K14519 0.0 0.0655270655270655 aldH; NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4] path:map00930,path:map01100,path:map01120,path:map01220 Caprolactam degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 452.0 29.0 0.0 1.0 1.0 C 0.0 29.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 29.0 0.0 1.0 0.0322275497285054 0.157646986573859 0.0949372681511822 0.1254194368453536 0 0 0 0 K14520 0.0 0.0056980056980056 hapE; 4-hydroxyacetophenone monooxygenase [EC:1.14.13.84] path:map00363,path:map01100,path:map01120 Bisphenol degradation,Metabolic pathways,Microbial metabolism in diverse environments 633.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 2.0 0.0 1.0 0 0 0 0 K14534 0.1342857142857142 0.0398860398860398 abfD; 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] path:map00650,path:map00720,path:map01100,path:map01120,path:map01200 Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 433.0 89.0 87.0 2.0 0.978021978021978 Q 64.0 27.0 1.0 1.0 COG2368 Aromatic_ring_hydroxylase YoaI 91.0 0.7032967032967034 0.2967032967032967 0.197609561679708 0.681752987906719 0.4396812747932135 0.484143426227011 0 0 0 0 K14537 0.0114285714285714 0.0 NUG2, GNL2; nuclear GTP-binding protein path:map03008 Ribosome biogenesis in eukaryotes 253.0 2.0 0.0 2.0 0.5 S 4.0 0.0 1.0 1.0 COG1161 Ribosome_biogenesis_GTPase_RbgA RbgA 4.0 1.0 0.0 0.155477800674567 0.0026995358139724 0.0790886682442697 0.1527782648605946 0 0 0 0 K14538 0.0028571428571428 0.0 NUG1, GNL3; nuclear GTP-binding protein path:map03008 Ribosome biogenesis in eukaryotes 142.0 1.0 0.0 1.0 1.0 FG 1.0 0.0 1.0 1.0 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 1.0 1.0 0.0 0 0 0 0 K14540 0.0114285714285714 0.2792022792022792 rbgA; ribosome biogenesis GTPase A 204.0 108.0 0.0 1.0 1.0 S 4.0 104.0 1.0 1.0 COG1161 Ribosome_biogenesis_GTPase_RbgA RbgA 108.0 0.037037037037037 0.9629629629629628 0.0140137183130621 0.0544435551355493 0.0342286367243057 0.0404298368224872 0 0 0 0 K14545 0.0142857142857142 0.0 RRP7; ribosomal RNA-processing protein 7 path:map03008 Ribosome biogenesis in eukaryotes 225.0 5.0 0.0 1.0 1.0 L 5.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 5.0 1.0 0.0 0.0863888279562441 0.80474442936036 0.445566628658302 0.7183556014041158 0 0 0 0 K14555 0.0028571428571428 0.0 UTP13, TBL3; U3 small nucleolar RNA-associated protein 13 path:map03008 Ribosome biogenesis in eukaryotes 721.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 KOG0319 1.0 1.0 0.0 0 0 0 0 K14558 0.0085714285714285 0.0028490028490028 PWP2, UTP1; periodic tryptophan protein 2 path:map03008 Ribosome biogenesis in eukaryotes 282.0 5.0 0.0 1.0 1.0 A 3.0 2.0 1.0 1.0 KOG0291 5.0 0.6 0.4 0.821788477923803 0.0003824076549021 0.4110854427893525 0.821406070268901 0 0 1 1 K14561 0.2971428571428571 0.0 IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 path:map03008 Ribosome biogenesis in eukaryotes 71.0 69.0 33.0 2.0 0.657142857142857 J 105.0 0.0 1.0 1.0 COG2136 rRNA_maturation_protein_Rpf1,_contains_Brix/IMP4_(anticodon-binding)_domain IMP4 105.0 1.0 0.0 0.82375379380635 0.59243874723618 0.708096270521265 0.2313150465701701 0 0 1 1 K14563 0.0085714285714285 0.0 NOP1, FBL; rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] path:map03008 Ribosome biogenesis in eukaryotes 207.0 2.0 1.0 2.0 0.666666666666667 A 3.0 0.0 1.0 1.0 COG1889 Fibrillarin-like_rRNA_2'-O-methylase_NOP1 NOP1 3.0 1.0 0.0 0 0 0 0 K14564 0.8628571428571429 0.0 NOP56; nucleolar protein 56 path:map03008,path:map05017 Ribosome biogenesis in eukaryotes,Spinocerebellar ataxia 152.0 306.0 304.0 2.0 0.993506493506493 J 308.0 0.0 2.0 0.996753246753247 COG1498 Box_C/D_ribonucleoprotein_Nop56/Prp31/SIK1_subunit SIK1 308.0 1.0 0.0 0.709189386994823 0.669765439848011 0.689477413421417 0.039423947146812 0 0 0 1 K14565 0.0057142857142857 0.0 NOP58; nucleolar protein 58 path:map03008 Ribosome biogenesis in eukaryotes 223.0 1.0 0.0 2.0 0.5 A 2.0 0.0 1.0 1.0 COG1498 Box_C/D_ribonucleoprotein_Nop56/Prp31/SIK1_subunit SIK1 2.0 1.0 0.0 0 0 0 0 K14566 0.0057142857142857 0.0 UTP24, FCF1; U3 small nucleolar RNA-associated protein 24 path:map03008 Ribosome biogenesis in eukaryotes 57.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG1997 Ribosomal_protein_L37AE/L43A RPL43A 2.0 1.0 0.0 0 0 0 0 K14568 0.3514285714285714 0.0 EMG1, NEP1; rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260] path:map03008 Ribosome biogenesis in eukaryotes 139.0 131.0 0.0 1.0 1.0 J 131.0 0.0 1.0 1.0 COG1756 rRNA_pseudouridine-1189_N-methylase_Emg1,_Nep1/Mra1_family Emg1 131.0 1.0 0.0 0.839149796892514 0.887421580263454 0.863285688577984 0.0482717833709399 0 0 1 1 K14571 0.0057142857142857 0.0056980056980056 RIX7, NVL; ribosome biogenesis ATPase path:map03008 Ribosome biogenesis in eukaryotes 288.0 4.0 0.0 1.0 1.0 O 2.0 2.0 1.0 1.0 COG0464 AAA+-type_ATPase,_SpoVK/Ycf46/Vps4_family SpoVK 4.0 0.5 0.5 0.602394517442081 0.299161815235695 0.450778166338888 0.3032327022063859 0 0 0 1 K14572 0.0085714285714285 0.0028490028490028 MDN1, REA1; midasin path:map03008 Ribosome biogenesis in eukaryotes 476.0 6.0 0.0 1.0 1.0 S 5.0 1.0 1.0 1.0 COG5271 Midasin,_AAA_ATPase_with__vWA_domain,_involved_in_ribosome_maturation MDN1 6.0 0.8333333333333334 0.1666666666666666 0.0077100442914548 1.20462609136568e-08 0.0038550281688578 0.0077100322451938 0 0 0 0 K14574 0.9457142857142856 0.0 SDO1, SBDS; ribosome maturation protein SDO1 path:map03008 Ribosome biogenesis in eukaryotes 205.0 334.0 0.0 1.0 1.0 J 334.0 0.0 1.0 1.0 COG1500 Ribosome_maturation_protein_Sdo1 Sdo1 334.0 1.0 0.0 0.646144096922559 0.977937420154273 0.812040758538416 0.3317933232317139 0 0 0 1 K14578 0.0028571428571428 0.017094017094017 nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component path:map00624,path:map00626,path:map00627,path:map00633,path:map00642,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Naphthalene degradation,Aminobenzoate degradation,Nitrotoluene degradation,Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 99.0 7.0 0.0 1.0 1.0 P 1.0 6.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 7.0 0.1428571428571428 0.8571428571428571 0.114567682572203 0.527847149244572 0.3212074159083875 0.413279466672369 0 0 0 0 K14579 0.0 0.0028490028490028 nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24] path:map00624,path:map00626,path:map00627,path:map00633,path:map00642,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Naphthalene degradation,Aminobenzoate degradation,Nitrotoluene degradation,Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 440.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 1.0 0.0 1.0 0 0 0 0 K14581 0.0028571428571428 0.0341880341880341 nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7] path:map00624,path:map00626,path:map00627,path:map00633,path:map00642,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Naphthalene degradation,Aminobenzoate degradation,Nitrotoluene degradation,Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 300.0 16.0 0.0 1.0 1.0 C 1.0 15.0 3.0 0.8125 COG0543 NAD(P)H-flavin_reductase Mcr1 16.0 0.0625 0.9375 0.0653644559820408 0.0702798850268043 0.0678221705044225 0.0049154290447634 0 0 0 0 K14582 0.0085714285714285 0.0028490028490028 nahB, doxE; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase [EC:1.3.1.29 1.3.1.60] path:map00624,path:map00626,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 252.0 4.0 0.0 1.0 1.0 IQ 3.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 4.0 0.75 0.25 0.0234918527555268 0.0888559432883615 0.0561738980219441 0.0653640905328346 0 0 0 0 K14583 0.0 0.0028490028490028 nahC; 1,2-dihydroxynaphthalene dioxygenase [EC:1.13.11.56] path:map00626,path:map01100,path:map01120,path:map01220 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 300.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 1.0 0.0 1.0 0 0 0 0 K14584 0.0 0.017094017094017 nahD; 2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4] path:map00626,path:map01100,path:map01120,path:map01220 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 193.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 1.0 1.0 COG3917 2-hydroxychromene-2-carboxylate_isomerase NahD 6.0 0.0 1.0 0.0040343188565136 0.0173150317349513 0.0106746752957324 0.0132807128784377 0 0 0 0 K14585 0.0028571428571428 0.0028490028490028 nahE; trans-o-hydroxybenzylidenepyruvate hydratase-aldolase [EC:4.1.2.45] path:map00626,path:map01100,path:map01120,path:map01220 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 327.0 1.0 0.0 2.0 0.5 E 1.0 1.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 2.0 0.5 0.5 0 0 0 0 K14587 0.0 0.0028490028490028 sgcE; protein sgcE [EC:5.1.3.-] 210.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0036 Pentose-5-phosphate-3-epimerase Rpe 1.0 0.0 1.0 0 0 0 0 K14588 0.0 0.0256410256410256 cueO; cuproxidase [EC:1.16.3.4] 105.0 4.0 3.0 2.0 0.8 Q 0.0 9.0 3.0 0.444444444444444 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 9.0 0.0 1.0 0.0097169669083077 0.0291695489072695 0.0194432579077886 0.0194525819989618 0 0 0 0 K14591 0.0228571428571428 0.0284900284900284 aroM; protein AroM 195.0 20.0 19.0 2.0 0.952380952380952 E 9.0 11.0 2.0 0.666666666666667 COG4126 Asp/Glu/hydantoin_racemase Dcg1 20.0 0.45 0.55 0.107306484172804 0.56324794807272 0.335277216122762 0.4559414638999161 0 0 0 0 K14596 0.0 0.0113960113960113 crtX; zeaxanthin glucosyltransferase [EC:2.4.1.276] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 397.0 5.0 4.0 2.0 0.833333333333333 CG 0.0 6.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 6.0 0.0 1.0 8.28250979257383e-12 0.093800776075805 0.0469003880420437 0.0938007760675224 0 0 0 0 K14597 0.02 0.0455840455840455 cruC; chlorobactene glucosyltransferase path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 251.0 16.0 8.0 2.0 0.666666666666667 M 7.0 17.0 3.0 0.666666666666667 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 24.0 0.2916666666666667 0.7083333333333334 0.0546213026583717 0.805352847141788 0.4299870749000798 0.7507315444834163 0 0 0 0 K14598 0.0 0.0227920227920227 cruD; chlorobactene lauroyltransferase path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 174.0 9.0 0.0 1.0 1.0 I 0.0 9.0 1.0 1.0 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 9.0 0.0 1.0 0.0051613245375499 0.0232149056602738 0.0141881150989118 0.0180535811227239 0 0 0 0 K14605 0.0 0.0484330484330484 cruA; lycopene cyclase CruA [EC:5.5.1.19] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 490.0 12.0 6.0 2.0 0.666666666666667 C 0.0 18.0 2.0 0.666666666666667 COG0644 Dehydrogenase_(flavoprotein) FixC 18.0 0.0 1.0 0.001245714599 0.005673833494637 0.0034597740468185 0.004428118895637 0 0 0 0 K14606 0.0028571428571428 0.0398860398860398 cruP; lycopene cyclase CruP [EC:5.5.1.19] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 476.0 10.0 6.0 3.0 0.625 CH 1.0 15.0 3.0 0.625 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 16.0 0.0625 0.9375 0.0006808926353744 1.08854624171441e-08 0.0003404517604184 0.0006808817499119 0 0 0 0 K14611 0.0 0.0028490028490028 SLC23A1, SVCT1; solute carrier family 23 (nucleobase transporter), member 1 path:map04977 Vitamin digestion and absorption 463.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 COG2233 Xanthine/uracil_permease UraA 1.0 0.0 1.0 0 0 0 0 K14623 0.0428571428571428 0.0769230769230769 dinD; DNA-damage-inducible protein D 116.0 32.0 11.0 2.0 0.60377358490566 S 19.0 37.0 5.0 0.642857142857143 COG3645 Phage_antirepressor_protein_YoqD,_KilAC_domain KilAC 56.0 0.3392857142857143 0.6607142857142857 0.307884938549661 0.123867784156788 0.2158763613532245 0.1840171543928729 0 0 0 0 K14626 0.0 0.0028490028490028 actVIA; actinorhodin biosynthesis protein ActVIA path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 152.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K14627 0.0 0.0056980056980056 actVI3; dehydratase [EC:4.2.1.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 202.0 0.0 2.0 1.0 1.0 2C28Q 2.0 0.0 1.0 0 0 0 0 K14628 0.0 0.0028490028490028 actVI2; enoyl reductase path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 331.0 0.0 1.0 1.0 1.0 2DYA3 1.0 0.0 1.0 0 0 0 0 K14629 0.0 0.0113960113960113 actVI4; enoyl reductase path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 95.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 4.0 0.0 1.0 2.07653175785454e-05 5.45658424411808e-06 1.311095091133174e-05 1.530873333442732e-05 0 0 0 0 K14630 0.0 0.0028490028490028 actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 363.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 1.0 0.0 1.0 0 0 0 0 K14631 0.0 0.0142450142450142 actVB; flavin reductase ActVB [EC:1.5.1.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 172.0 4.0 3.0 2.0 0.8 S 0.0 5.0 2.0 0.8 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 5.0 0.0 1.0 3.6116362171319097e-12 7.41374896516006e-12 5.512692591145985e-12 3.802112748028151e-12 0 0 0 0 K14633 0.0 0.0056980056980056 gra6, RED2; ketoreductase RED2 [EC:1.1.1.-] path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 236.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K14638 0.0028571428571428 0.0028490028490028 SLC15A3_4, PHT; solute carrier family 15 (peptide/histidine transporter), member 3/4 139.0 1.0 0.0 2.0 0.5 EF 1.0 1.0 2.0 0.5 COG0462 Phosphoribosylpyrophosphate_synthetase PrsA 2.0 0.5 0.5 0 0 0 0 K14645 0.14 0.2564102564102564 K14645; serine protease [EC:3.4.21.-] path:map02024 Quorum sensing 42.0 202.0 183.0 7.0 0.841666666666667 O 90.0 150.0 11.0 0.870833333333333 COG1404 Serine_protease,_subtilisin_family AprE 240.0 0.375 0.625 0.0010216949691538 0.324944757947771 0.1629832264584624 0.3239230629786172 0 0 0 0 K14647 0.0457142857142857 0.0256410256410256 vpr; minor extracellular serine protease Vpr [EC:3.4.21.-] 235.0 35.0 32.0 2.0 0.921052631578947 O 18.0 19.0 3.0 0.921052631578947 COG1404 Serine_protease,_subtilisin_family AprE 37.0 0.4864864864864865 0.5135135135135135 0.973606480089023 0.460660546846425 0.7171335134677239 0.512945933242598 1 1 1 1 K14648 0.0 0.0028490028490028 ENDOU, PP11; poly(U)-specific endoribonuclease [EC:3.1.-.-] 442.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG5634 Uncharacterized_conserved_protein_YukJ,_DUF2278_family YukJ 1.0 0.0 1.0 0 0 0 0 K14652 0.1228571428571428 0.7891737891737892 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] path:map00740,path:map00790,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Folate biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 286.0 355.0 347.0 2.0 0.977961432506887 H 46.0 317.0 4.0 0.898071625344353 COG0108 3,4-dihydroxy-2-butanone_4-phosphate_synthase RibB 363.0 0.1267217630853994 0.8732782369146006 0.143365254841166 0.308071111444353 0.2257181831427595 0.164705856603187 0 0 0 0 K14653 0.0742857142857142 0.0 arfB; 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC:3.5.1.102] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 164.0 17.0 8.0 2.0 0.653846153846154 H 26.0 0.0 1.0 1.0 COG1402 Creatinine_amidohydrolase/Fe(II)-dependent_FAPy_formamide_hydrolase_(riboflavin_and_F420_biosynthesis) ArfB 26.0 1.0 0.0 0.454970548546453 0.280656388498031 0.367813468522242 0.174314160048422 0 0 0 0 K14654 0.5142857142857142 0.0085470085470085 RIB7, arfC; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302] path:map00740,path:map01100,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of cofactors 136.0 205.0 198.0 2.0 0.966981132075471 H 208.0 4.0 1.0 1.0 COG1985 Pyrimidine_reductase,_riboflavin_biosynthesis RibD 212.0 0.981132075471698 0.0188679245283018 0.676786573152332 0.785525566632233 0.7311560698922825 0.108738993479901 0 0 0 1 K14656 0.8028571428571428 0.0284900284900284 ribL; FAD synthetase [EC:2.7.7.2] path:map00740,path:map01100,path:map01110 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 84.0 216.0 127.0 4.0 0.666666666666667 F 314.0 10.0 3.0 0.938271604938272 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 324.0 0.9691358024691358 0.0308641975308641 0.52374610583524 0.319654629145459 0.4217003674903494 0.2040914766897809 0 1 0 1 K14657 0.0 0.0085470085470085 nodD; LysR family transcriptional regulator, nod-box dependent transcriptional activator 246.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.0121928368693714 0.0267240649903546 0.019458450929863 0.0145312281209832 0 0 0 0 K14658 0.0028571428571428 0.0227920227920227 nodA; nodulation protein A [EC:2.3.1.-] 245.0 5.0 0.0 2.0 0.5 S 1.0 9.0 2.0 0.9 COG3153 Predicted_N-acetyltransferase_YhbS yhbS 10.0 0.1 0.9 0.0765843237332096 0.189362844133303 0.1329735839332563 0.1127785204000934 0 0 0 0 K14659 0.0 0.0085470085470085 nodB; chitooligosaccharide deacetylase [EC:3.5.1.-] 190.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 4.0 0.0 1.0 0.0266009886488465 0.0549765042976179 0.0407887464732322 0.0283755156487713 0 0 0 0 K14660 0.0 0.0797720797720797 nodE; nodulation protein E [EC:2.3.1.-] 392.0 19.0 9.0 3.0 0.633333333333333 I 0.0 30.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 30.0 0.0 1.0 0.0016115796480773 0.0604501736178928 0.031030876632985 0.0588385939698155 0 0 0 0 K14661 0.0 0.0085470085470085 nodF; nodulation protein F [EC:2.3.1.-] 74.0 3.0 0.0 1.0 1.0 IQ 0.0 3.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 3.0 0.0 1.0 0 0 0 0 K14664 0.0085714285714285 0.0028490028490028 ILR1; IAA-amino acid hydrolase [EC:3.5.1.-] 388.0 3.0 2.0 2.0 0.75 S 3.0 1.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 4.0 0.75 0.25 0.0353512454140817 0.0731364118355674 0.0542438286248245 0.0377851664214857 0 0 0 0 K14665 0.0 0.0227920227920227 amhX; amidohydrolase [EC:3.5.1.-] 362.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 8.0 0.0 1.0 0.0429131032463302 0.124097266154714 0.0835051847005221 0.0811841629083838 0 0 0 0 K14666 0.0142857142857142 0.0199430199430199 nodC; N-acetylglucosaminyltransferase [EC:2.4.1.-] 313.0 12.0 0.0 1.0 1.0 M 5.0 7.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 12.0 0.4166666666666667 0.5833333333333334 0.0601503889566375 0.311094791235524 0.1856225900960807 0.2509444022788865 0 0 0 0 K14667 0.0 0.0199430199430199 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] 397.0 6.0 4.0 2.0 0.75 IQ 0.0 8.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 8.0 0.0 1.0 0.0062928432361244 0.0202326246158461 0.0132627339259852 0.0139397813797217 0 0 0 0 K14668 0.0 0.0113960113960113 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] 397.0 4.0 0.0 1.0 1.0 IQ 0.0 4.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 4.0 0.0 1.0 1.32329023244882e-06 0.0001982427603731 9.97830253027744e-05 0.0001969194701406 0 0 0 0 K14669 0.0 0.0056980056980056 whiEV; minimal PKS acyl carrier protein 80.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 2.0 0.0 1.0 0 0 0 0 K14670 0.0 0.0341880341880341 whiEVI; aromatase 98.0 9.0 6.0 3.0 0.642857142857143 I 0.0 14.0 4.0 0.642857142857143 COG2867 Ribosome_association_toxin_PasT_(RatA)_of_the_RatAB_toxin-antitoxin_module PasT 14.0 0.0 1.0 0.0088430637567177 0.044214223704204 0.0265286437304608 0.0353711599474863 0 0 0 0 K14671 0.0 0.0199430199430199 whiEVII; cyclase 105.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 2C9N8 9.0 0.0 1.0 4.9850313364955e-05 0.0005456339908164 0.0002977421520906 0.0004957836774514 0 0 0 0 K14672 0.0 0.0056980056980056 whiEVIII; putative polyketide hydroxylase 508.0 2.0 0.0 1.0 1.0 CH 0.0 2.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 2.0 0.0 1.0 0 0 0 0 K14673 0.0028571428571428 0.0284900284900284 whiEII; putative monooxygenase 98.0 8.0 5.0 3.0 0.666666666666667 G 1.0 11.0 2.0 0.75 COG0662 Mannose-6-phosphate_isomerase,_cupin_superfamily ManC 12.0 0.0833333333333333 0.9166666666666666 0.0550407874234432 0.0912216940974357 0.0731312407604394 0.0361809066739925 0 0 0 0 K14676 0.0 0.0056980056980056 NTE, NRE; lysophospholipid hydrolase [EC:3.1.1.5] path:map00564 Glycerophospholipid metabolism 59.0 1.0 0.0 2.0 0.5 I 0.0 2.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 2.0 0.0 1.0 0 0 0 0 K14680 0.0028571428571428 0.0199430199430199 E6.5.1.3; RNA ligase [EC:6.5.1.3] 186.0 6.0 5.0 3.0 0.75 T 1.0 7.0 2.0 0.75 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 8.0 0.125 0.875 0.10853545755066 0.101015463461376 0.104775460506018 0.0075199940892839 0 0 0 0 K14681 0.0057142857142857 0.0541310541310541 argHA; argininosuccinate lyase / amino-acid N-acetyltransferase [EC:4.3.2.1 2.3.1.1] path:map00220,path:map00250,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 128.0 23.0 0.0 1.0 1.0 E 2.0 21.0 2.0 0.521739130434783 COG0165 Argininosuccinate_lyase ArgH 23.0 0.0869565217391304 0.9130434782608696 0.269703252756525 0.0444127263156001 0.1570579895360625 0.2252905264409249 0 0 0 0 K14682 0.0 0.0997150997150997 argAB; amino-acid N-acetyltransferase [EC:2.3.1.1] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 331.0 32.0 27.0 2.0 0.864864864864865 E 0.0 37.0 3.0 0.837837837837838 COG0548 N-acetylglutamate_kinase ArgB 37.0 0.0 1.0 0.0048160158365998 0.0143044430874015 0.0095602294620006 0.0094884272508017 0 0 0 0 K14683 0.0285714285714285 0.0512820512820512 SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter) path:map04928,path:map04978 Parathyroid hormone synthesis, secretion and action,Mineral absorption 290.0 29.0 0.0 1.0 1.0 P 11.0 18.0 1.0 1.0 COG1283 Na+/phosphate_symporter NptA 29.0 0.3793103448275862 0.6206896551724138 0.0332512832176781 0.0413456284476531 0.0372984558326656 0.008094345229975 0 0 0 0 K14696 0.0057142857142857 0.0199430199430199 SLC30A9, ZNT9; solute carrier family 30 (zinc transporter), member 9 281.0 9.0 0.0 1.0 1.0 P 2.0 7.0 1.0 1.0 COG0053 Divalent_metal_cation_(Fe/Co/Zn/Cd)_efflux_pump FieF 9.0 0.2222222222222222 0.7777777777777778 0.269975231104459 0.368651941003238 0.3193135860538485 0.098676709898779 0 0 0 0 K14698 0.0 0.0085470085470085 irtA, ybtP; ATP-binding cassette, subfamily B, bacterial IrtA/YbtP [EC:7.-.-.-] path:map02010 ABC transporters 223.0 3.0 2.0 2.0 0.75 P 0.0 4.0 2.0 0.75 COG2375 NADPH-dependent_ferric_siderophore_reductase,_contains_FAD-binding_and_SIP_domains ViuB 4.0 0.0 1.0 1.7767685850554e-07 8.8928946649205e-05 4.4553311753855273e-05 8.875126979069946e-05 0 0 0 0 K14699 0.0 0.0028490028490028 irtB, ybtQ; ATP-binding cassette, subfamily B, bacterial IrtB/YbtQ [EC:7.-.-.-] path:map02010 ABC transporters 578.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 1.0 0.0 1.0 0 0 0 0 K14713 0.0057142857142857 0.0 SLC39A7, KE4, ZIP7; solute carrier family 39 (zinc transporter), member 7 path:map05010,path:map05012 Alzheimer disease,Parkinson disease 188.0 2.0 0.0 1.0 1.0 E 2.0 0.0 1.0 1.0 COG0131 Imidazoleglycerol_phosphate_dehydratase_HisB HisB2 2.0 1.0 0.0 0 0 0 0 K14715 0.0114285714285714 0.0 SLC39A9, ZIP9; solute carrier family 39 (zinc transporter), member 9 path:map05010,path:map05012 Alzheimer disease,Parkinson disease 249.0 4.0 0.0 1.0 1.0 P 4.0 0.0 1.0 1.0 KOG3907 4.0 1.0 0.0 0.0130766211028827 0.0376771028248393 0.025376861963861 0.0246004817219566 0 0 0 0 K14727 0.0 0.0 pcaL; 3-oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase [EC:3.1.1.24 4.1.1.44] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 25.0 15.0 3.0 0.657894736842105 I 0.0 0.0 3.0 0.631578947368421 COG0599 Uncharacterized_conserved_protein_YurZ,_alkylhydroperoxidase/carboxymuconolactone_decarboxylase_family YurZ 0.0 0 0 0 0 K14728 0.1171428571428571 0.0056980056980056 K14728; phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [EC:1.2.-.-] 262.0 55.0 0.0 1.0 1.0 C 51.0 4.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 55.0 0.9272727272727272 0.0727272727272727 0.909178876308446 0.988010572397178 0.948594724352812 0.078831696088732 0 0 1 1 K14729 0.0028571428571428 0.0 FOX2; multifunctional beta-oxidation protein [EC:4.2.1.- 1.1.1.-] path:map00410,path:map00640,path:map01100,path:map01200 beta-Alanine metabolism,Propanoate metabolism,Metabolic pathways,Carbon metabolism 298.0 1.0 0.0 1.0 1.0 Q 1.0 0.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 1.0 0.0 0 0 0 0 K14731 0.04 0.1111111111111111 mlhB, chnC; epsilon-lactone hydrolase [EC:3.1.1.83] path:map00903,path:map00930,path:map01110,path:map01220 Limonene and pinene degradation,Caprolactam degradation,Biosynthesis of secondary metabolites,Degradation of aromatic compounds 175.0 71.0 0.0 1.0 1.0 I 15.0 56.0 1.0 1.0 COG0657 Acetyl_esterase/lipase Aes 71.0 0.2112676056338028 0.7887323943661971 0.0092362662458187 0.391124436434011 0.2001803513399148 0.3818881701881923 0 0 0 0 K14733 0.0 0.0142450142450142 limB; limonene 1,2-monooxygenase [EC:1.14.13.107] path:map00903,path:map01110 Limonene and pinene degradation,Biosynthesis of secondary metabolites 90.0 9.0 0.0 1.0 1.0 C 0.0 9.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 9.0 0.0 1.0 0.0158192162523159 0.0284028268756762 0.022111021563996 0.0125836106233603 0 0 0 0 K14736 0.0028571428571428 0.0 TF; transferrin path:map04066,path:map04216,path:map04978 HIF-1 signaling pathway,Ferroptosis,Mineral absorption 711.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 28KI0 1.0 1.0 0.0 0 0 0 0 K14742 0.0085714285714285 0.7350427350427351 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB 46.0 259.0 241.0 2.0 0.935018050541516 O 3.0 274.0 2.0 0.92057761732852 COG1214 tRNA_A37_threonylcarbamoyladenosine_modification_protein_TsaB TsaB 277.0 0.0108303249097472 0.9891696750902528 0.300581341264852 0.798568567950882 0.549574954607867 0.49798722668603 0 0 0 0 K14743 0.0 0.0512820512820512 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-] 240.0 40.0 38.0 2.0 0.952380952380952 O 0.0 42.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 42.0 0.0 1.0 0.0034228234753495 0.0817089918452467 0.0425659076602981 0.0782861683698972 0 0 0 0 K14744 0.0 0.0056980056980056 rzpD; prophage endopeptidase [EC:3.4.-.-] 90.0 4.0 0.0 1.0 1.0 S 0.0 4.0 3.0 0.5 2DP4N 4.0 0.0 1.0 3.8219444733452994e-12 2.62933806058999e-06 1.3146709412672315e-06 2.629334238645517e-06 0 0 0 0 K14747 0.0 0.0028490028490028 bal; benzoylacetate-CoA ligase [EC:6.2.1.-] path:map00642,path:map01120,path:map01220 Ethylbenzene degradation,Microbial metabolism in diverse environments,Degradation of aromatic compounds 451.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 1.0 0.0 1.0 0 0 0 0 K14748 0.0 0.0142450142450142 etbAa; ethylbenzene dioxygenase subunit alpha [EC:1.14.12.-] path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 276.0 6.0 4.0 2.0 0.75 P 0.0 8.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 8.0 0.0 1.0 4.85316414844339e-12 0.0406742757823664 0.0203371378936097 0.0406742757775132 0 0 0 0 K14749 0.0 0.0113960113960113 etbAb; ethylbenzene dioxygenase subunit beta [EC:1.14.12.-] path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 166.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 6.0 0.0 1.0 0.0036884159328941 0.0109620558323915 0.0073252358826428 0.0072736398994973 0 0 0 0 K14750 0.0028571428571428 0.0085470085470085 etbAc; ethylbenzene dioxygenase ferredoxin component path:map00642,path:map01100,path:map01220 Ethylbenzene degradation,Metabolic pathways,Degradation of aromatic compounds 95.0 4.0 0.0 1.0 1.0 P 1.0 3.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 4.0 0.25 0.75 0.123790561331165 0.256107752607233 0.189949156969199 0.132317191276068 0 0 0 0 K14751 0.0 0.0028490028490028 etbC; 2,3-dihydroxyethylbenzene 1,2-dioxygenase [EC:1.13.11.-] path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 300.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 1.0 0.0 1.0 0 0 0 0 K14753 0.0028571428571428 0.0 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein path:map05162 Measles 382.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 KOG0279 1.0 1.0 0.0 0 0 0 0 K14755 0.0 0.0056980056980056 CRNS1, ATPGD1; carnosine synthase [EC:6.3.2.11] path:map00330,path:map00340,path:map00410,path:map01100 Arginine and proline metabolism,Histidine metabolism,beta-Alanine metabolism,Metabolic pathways 183.0 1.0 0.0 2.0 0.5 I 0.0 2.0 2.0 0.5 COG0439 Biotin_carboxylase AccC 2.0 0.0 1.0 0 0 0 0 K14761 0.0057142857142857 0.2849002849002849 ybcJ; ribosome-associated protein 50.0 103.0 0.0 1.0 1.0 S 2.0 101.0 2.0 0.990291262135922 COG2501 Ribosome-associated_protein_YbcJ,_S4-like_RNA-binding_protein YbcJ 103.0 0.0194174757281553 0.9805825242718448 0.0188687421899366 0.0867273296484824 0.0527980359192095 0.0678585874585458 0 0 0 0 K14762 0.0 0.0142450142450142 yibL; ribosome-associated protein 117.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2AN7V 5.0 0.0 1.0 0.0044345146698574 0.0093678209431167 0.006901167806487 0.0049333062732593 0 0 0 0 K14776 0.0 0.0028490028490028 DDX10, DBP4; ATP-dependent RNA helicase DDX10/DBP4 [EC:3.6.4.13] 257.0 1.0 0.0 1.0 1.0 EH 0.0 1.0 1.0 1.0 COG0175 3'-phosphoadenosine_5'-phosphosulfate_sulfotransferase_(PAPS_reductase)/FAD_synthetase_or_related_enzyme CysD 1.0 0.0 1.0 0 0 0 0 K14807 0.0028571428571428 0.0 DDX51, DBP6; ATP-dependent RNA helicase DDX51/DBP6 [EC:3.6.4.13] 70.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1383 Ribosomal_protein_S17E RPS17A 1.0 1.0 0.0 0 0 0 0 K14819 0.0057142857142857 0.0 DUSP12, YVH1; dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48] 133.0 1.0 0.0 2.0 0.5 V 2.0 0.0 1.0 1.0 COG2453 Protein-tyrosine_phosphatase CDC14 2.0 1.0 0.0 0 0 0 0 K14826 0.0 0.0028490028490028 FPR3_4; FK506-binding nuclear protein [EC:5.2.1.8] 225.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0545 FKBP-type_peptidyl-prolyl_cis-trans_isomerase FkpA 1.0 0.0 1.0 0 0 0 0 K14835 0.0028571428571428 0.0 NOP2; 25S rRNA (cytosine2870-C5)-methyltransferase [EC:2.1.1.310] 307.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 1.0 1.0 0.0 0 0 0 0 K14857 0.0028571428571428 0.0 SPB1, FTSJ3; AdoMet-dependent rRNA methyltransferase SPB1 [EC:2.1.1.-] 181.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG0293 23S_rRNA_U2552_(ribose-2'-O)-methylase_RlmE/FtsJ RlmE 1.0 1.0 0.0 0 0 0 0 K14940 0.0914285714285714 0.0598290598290598 cofF; gamma-F420-2:alpha-L-glutamate ligase [EC:6.3.2.32] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 143.0 42.0 27.0 4.0 0.65625 HJ 34.0 30.0 1.0 1.0 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 64.0 0.53125 0.46875 0.917997720557098 0.984638383147625 0.9513180518523616 0.0666406625905269 1 1 1 1 K14941 0.3457142857142857 0.0883190883190883 cofC, fbiD; 2-phospho-L-lactate/phosphoenolpyruvate guanylyltransferase [EC:2.7.7.68 2.7.7.105] path:map00680,path:map01100,path:map01120,path:map01240 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Biosynthesis of cofactors 101.0 129.0 104.0 2.0 0.837662337662338 H 122.0 32.0 1.0 1.0 COG1920 2-phospho-L-lactate_guanylyltransferase,_coenzyme_F420_biosynthesis_enzyme,_CobY/MobA/RfbA_family 154.0 0.7922077922077922 0.2077922077922078 0.200161509294513 0.152964467630521 0.176562988462517 0.047197041663992 0 0 0 0 K14949 0.0 0.0655270655270655 pknG; serine/threonine-protein kinase PknG [EC:2.7.11.1] path:map05152 Tuberculosis 194.0 10.0 0.0 5.0 0.357142857142857 O 0.0 30.0 6.0 0.333333333333333 COG0515 Serine/threonine_protein_kinase SPS1 30.0 0.0 1.0 0.0582259471285387 0.0865851475323295 0.0724055473304341 0.0283592004037908 0 0 0 0 K14952 0.0085714285714285 0.0256410256410256 namH; UDP-MurNAc hydroxylase path:map05152 Tuberculosis 325.0 7.0 1.0 2.0 0.538461538461538 P 3.0 10.0 2.0 0.538461538461538 COG2220 L-ascorbate_lactonase_UlaG,_metallo-beta-lactamase_superfamily UlaG 13.0 0.2307692307692307 0.7692307692307693 0.068750411768393 0.0858090231204605 0.0772797174444267 0.0170586113520675 0 0 0 0 K14953 0.0 0.0028490028490028 lpqH; ipoprotein LpqH path:map05152 Tuberculosis 148.0 3.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 28UBJ 3.0 0.0 1.0 0 0 0 0 K14954 0.0 0.0398860398860398 lprG; lipoprotein LprG path:map05152 Tuberculosis 195.0 14.0 0.0 1.0 1.0 S 0.0 14.0 3.0 0.785714285714286 2DQVM 14.0 0.0 1.0 0.0075544577335314 0.770014721063924 0.3887845893987277 0.7624602633303926 0 0 0 0 K14955 0.0 0.0113960113960113 lprA; lipoprotein LprA path:map05152 Tuberculosis 198.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2DQVM 4.0 0.0 1.0 0.0001794720053955 0.0009783673819116 0.0005789196936535 0.0007988953765161 0 0 0 0 K14956 0.0 0.0199430199430199 esxA, esat6; 6 kDa early secretory antigenic target path:map05152 Tuberculosis 93.0 8.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG4842 Secreted_virulence_factor_YukE/EsxA,_WXG100_family EsxA 8.0 0.0 1.0 3.57514103261877e-05 3.2196435961828e-05 3.3973923144007845e-05 3.554974364359697e-06 0 0 0 0 K14974 0.0 0.0142450142450142 nicC; 6-hydroxynicotinate 3-monooxygenase [EC:1.14.13.114] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 373.0 4.0 3.0 2.0 0.8 CH 0.0 5.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 5.0 0.0 1.0 0.0385230894288172 0.0853369700416307 0.0619300297352239 0.0468138806128135 0 0 0 0 K14977 0.0 0.0683760683760683 ylbA, UGHY; (S)-ureidoglycine aminohydrolase [EC:3.5.3.26] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 227.0 23.0 22.0 3.0 0.92 S 0.0 25.0 1.0 1.0 COG3257 Ureidoglycine_aminohydrolase AllE 25.0 0.0 1.0 0.0263268077055193 0.0876888556218479 0.0570078316636836 0.0613620479163286 0 0 0 0 K14978 0.0 0.017094017094017 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA path:map02020 Two-component system 237.0 6.0 0.0 1.0 1.0 T 0.0 6.0 5.0 0.333333333333333 COG3850 Signal_transduction_histidine_kinase_NarQ,_nitrate/nitrite-specific NarQ 6.0 0.0 1.0 0.009077498837755 0.0563293467324001 0.0327034227850775 0.0472518478946451 0 0 0 0 K14979 0.0 0.0056980056980056 ssrB; two-component system, LuxR family, secretion system response regulator SsrB path:map02020 Two-component system 166.0 1.0 0.0 2.0 0.5 K 0.0 2.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 2.0 0.0 1.0 0 0 0 0 K14980 0.0 0.0997150997150997 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3] path:map02020 Two-component system 345.0 37.0 0.0 1.0 1.0 T 0.0 37.0 3.0 0.513513513513514 COG0642 Signal_transduction_histidine_kinase BaeS 37.0 0.0 1.0 0.0010977131060243 0.0666879746293503 0.0338928438676873 0.065590261523326 0 0 0 0 K14981 0.0 0.0883190883190883 chvI; two-component system, OmpR family, response regulator ChvI path:map02020 Two-component system 212.0 26.0 21.0 3.0 0.764705882352941 T 0.0 34.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 34.0 0.0 1.0 0.0001717989105345 0.0002809355779018 0.0002263672442181 0.0001091366673672 0 0 0 0 K14982 0.0028571428571428 0.017094017094017 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 145.0 10.0 0.0 1.0 1.0 T 1.0 9.0 2.0 0.6 COG5002 Sensor_histidine_kinase_WalK WalK 10.0 0.1 0.9 0.0024162416794275 0.0058616403597543 0.0041389410195909 0.0034453986803268 0 0 0 0 K14983 0.0 0.0085470085470085 ciaR; two-component system, OmpR family, response regulator CiaR path:map02020,path:map02024 Two-component system,Quorum sensing 126.0 2.0 1.0 2.0 0.666666666666667 T 0.0 3.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 3.0 0.0 1.0 0 0 0 0 K14986 0.0142857142857142 0.1054131054131054 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] path:map02020 Two-component system 129.0 46.0 45.0 2.0 0.978723404255319 T 5.0 44.0 17.0 0.326530612244898 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 49.0 0.1020408163265306 0.8979591836734694 0.0146622003173274 0.0581440095046064 0.0364031049109669 0.043481809187279 0 0 0 0 K14987 0.0 0.0455840455840455 fixJ; two-component system, LuxR family, response regulator FixJ path:map02020 Two-component system 169.0 15.0 0.0 2.0 0.5 T 0.0 30.0 1.0 1.0 COG4566 DNA-binding_response_regulator,_FixJ_family,_consists_of_REC_and_HTH_domains FixJ 30.0 0.0 1.0 0.0007468253942467 0.0016970749999189 0.0012219501970828 0.0009502496056722 0 0 0 0 K14988 0.0 0.0056980056980056 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK path:map02020 Two-component system 345.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG4585 Signal_transduction_histidine_kinase_ComP ComP 3.0 0.0 1.0 0 0 0 0 K14998 0.0 0.1168091168091168 SURF1, SHY1; surfeit locus 1 family protein 135.0 51.0 0.0 1.0 1.0 S 0.0 51.0 1.0 1.0 COG3346 Cytochrome_oxidase_assembly_protein_ShyY1 Shy1 51.0 0.0 1.0 0.0039647601797344 0.121731619060681 0.0628481896202077 0.1177668588809466 0 0 0 0 K15011 0.0 0.131054131054131 regB, regS, actS; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] path:map02020 Two-component system 218.0 54.0 53.0 2.0 0.981818181818182 T 0.0 55.0 5.0 0.490909090909091 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 55.0 0.0 1.0 0.0028219934845561 0.0232817651681321 0.0130518793263441 0.020459771683576 0 0 0 0 K15012 0.0 0.1111111111111111 regA, regR, actR; two-component system, response regulator RegA path:map02020 Two-component system 154.0 43.0 42.0 2.0 0.977272727272727 T 0.0 44.0 2.0 0.931818181818182 COG4567 DNA-binding_response_regulator,_ActR/RegA_family,_consists_of_REC_and_Fis-type_HTH_domains 44.0 0.0 1.0 0.0030243699752651 0.0079385136006616 0.0054814417879633 0.0049141436253964 0 0 0 0 K15016 0.3228571428571428 0.0142450142450142 K15016; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 300.0 203.0 0.0 1.0 1.0 I 190.0 5.0 2.0 0.990147783251232 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 195.0 0.9743589743589745 0.0256410256410256 0.368183509237714 0.120494236475716 0.244338872856715 0.2476892727619979 0 0 0 0 K15017 0.0514285714285714 0.0 K15017; malonyl-CoA/succinyl-CoA reductase (NADPH) [EC:1.2.1.75 1.2.1.76] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 338.0 19.0 0.0 1.0 1.0 E 19.0 0.0 1.0 1.0 COG0136 Aspartate-semialdehyde_dehydrogenase Asd 19.0 1.0 0.0 0.0115550416104107 0.0544054004165445 0.0329802210134776 0.0428503588061338 0 0 0 0 K15018 0.02 0.0 K15018; 3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 644.0 7.0 0.0 1.0 1.0 I 7.0 0.0 1.0 1.0 COG0365 Acyl-coenzyme_A_synthetase/AMP-(fatty)_acid_ligase Acs 7.0 1.0 0.0 4.25825121217819e-22 4.15928345288104e-17 2.0796630176965808e-17 4.159240870368918e-17 0 0 0 0 K15019 0.1285714285714285 0.0028490028490028 K15019; 3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 225.0 56.0 0.0 1.0 1.0 I 54.0 1.0 2.0 0.553571428571429 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 55.0 0.9818181818181818 0.0181818181818181 0.101385189419788 0.268774659495752 0.18507992445777 0.167389470075964 0 0 0 0 K15020 0.0885714285714285 0.0 K15020; acryloyl-coenzyme A reductase [EC:1.3.1.84] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 306.0 41.0 0.0 1.0 1.0 C 41.0 0.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 41.0 1.0 0.0 0.0779217909100567 0.289557237651542 0.1837395142807993 0.2116354467414853 0 0 0 0 K15022 0.0085714285714285 0.0683760683760683 fdhB; formate dehydrogenase (NADP+) beta subunit [EC:1.17.1.10] path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 467.0 24.0 22.0 3.0 0.857142857142857 C 3.0 25.0 2.0 0.928571428571429 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 28.0 0.1071428571428571 0.8928571428571429 0.112501768189219 0.973794990598143 0.543148379393681 0.861293222408924 0 0 0 0 K15023 0.0171428571428571 0.1025641025641025 acsE; 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 232.0 34.0 18.0 2.0 0.68 E 6.0 43.0 2.0 0.68 COG1410 Methionine_synthase_I,_cobalamin-binding_domain MetH2 49.0 0.1224489795918367 0.8775510204081632 0.0396999794277079 0.967001785185143 0.5033508823064254 0.9273018057574351 0 0 0 0 K15024 0.0057142857142857 0.0712250712250712 K15024; putative phosphotransacetylase [EC:2.3.1.8] path:map00430,path:map00620,path:map00640,path:map00720,path:map01100,path:map01120,path:map01200 Taurine and hypotaurine metabolism,Pyruvate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 179.0 31.0 30.0 2.0 0.96875 Q 2.0 30.0 2.0 0.96875 COG4869 Propanediol_utilization_protein PduL 32.0 0.0625 0.9375 0.0551169053432197 0.0469476267102194 0.0510322660267195 0.0081692786330003 0 0 0 0 K15034 0.0 0.3789173789173789 yaeJ; ribosome-associated protein 102.0 136.0 0.0 1.0 1.0 J 0.0 136.0 2.0 0.772058823529412 COG1186 Protein_chain_release_factor_PrfB PrfB 136.0 0.0 1.0 0.0776766085297736 0.421221712181063 0.2494491603554183 0.3435451036512894 0 0 0 0 K15036 0.0514285714285714 0.0 K15036; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 511.0 19.0 0.0 1.0 1.0 I 19.0 0.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 19.0 1.0 0.0 0.0005392048407472 0.0024970295111567 0.0015181171759519 0.0019578246704095 0 0 0 0 K15037 0.0628571428571428 0.0028490028490028 K15037; biotin carboxyl carrier protein path:map00280,path:map00630,path:map00640,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 114.0 17.0 11.0 2.0 0.739130434782609 I 22.0 1.0 2.0 0.739130434782609 COG0511 Biotin_carboxyl_carrier_protein AccB 23.0 0.9565217391304348 0.0434782608695652 0.0005813487631927 0.0027056633111083 0.0016435060371505 0.0021243145479155 0 0 0 0 K15038 0.0428571428571428 0.0 K15038; succinyl-CoA reductase [EC:1.2.1.76] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 441.0 21.0 0.0 1.0 1.0 C 21.0 0.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 21.0 1.0 0.0 0.0677398164583053 0.0735385563056655 0.0706391863819854 0.0057987398473601 0 0 0 0 K15039 0.02 0.0 K15039; 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 314.0 7.0 0.0 1.0 1.0 I 7.0 0.0 1.0 1.0 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 7.0 1.0 0.0 4.25825121217634e-22 4.15936458649001e-17 2.0797035845010657e-17 4.159322003977889e-17 0 0 0 0 K15045 0.0714285714285714 0.0398860398860398 RSAD2; radical S-adenosyl methionine domain-containing protein 2 path:map05160,path:map05164 Hepatitis C,Influenza A 27.0 16.0 6.0 5.0 0.380952380952381 S 28.0 14.0 2.0 0.833333333333333 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 42.0 0.6666666666666666 0.3333333333333333 0.244307066151077 0.116379659584065 0.180343362867571 0.127927406567012 0 0 0 0 K15051 0.0 0.0 endA; DNA-entry nuclease 20.0 9.0 2.0 0.645161290322581 K 0.0 0.0 5.0 0.709677419354839 COG2169 Methylphosphotriester-DNA--protein-cysteine_methyltransferase_(N-terminal_fragment_of_Ada),_contains_Zn-binding_and_two_AraC-type_DNA-binding_domains AdaA 0.0 0 0 0 0 K15052 0.0142857142857142 0.0313390313390313 K15052; propionyl-CoA carboxylase [EC:6.4.1.3 2.1.3.15] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 530.0 16.0 0.0 1.0 1.0 I 5.0 11.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 16.0 0.3125 0.6875 0.0164441061959164 0.370966495673002 0.1937053009344592 0.3545223894770856 0 0 0 0 K15054 0.0 0.0427350427350427 mdlB; (S)-mandelate dehydrogenase [EC:1.1.99.31] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 341.0 22.0 0.0 1.0 1.0 C 0.0 22.0 1.0 1.0 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 22.0 0.0 1.0 0.0222938223823683 0.041459836683681 0.0318768295330246 0.0191660143013127 0 0 0 0 K15058 0.0371428571428571 0.0028490028490028 amnA; 2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit alpha path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 279.0 16.0 14.0 2.0 0.888888888888889 S 16.0 2.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 18.0 0.8888888888888888 0.1111111111111111 9.61168462874602e-08 1.48453662850654e-08 5.54811062862628e-08 8.127148000239482e-08 0 0 0 0 K15059 0.0371428571428571 0.0028490028490028 amnB; 2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit beta [EC:1.13.11.74 1.13.11.76] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 293.0 16.0 0.0 1.0 1.0 S 15.0 1.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 16.0 0.9375 0.0625 0.0027247635166951 0.0021353726907323 0.0024300681037137 0.0005893908259628 0 0 0 0 K15060 0.0 0.0056980056980056 ligXa; 5,5'-dehydrodivanillate O-demethylase oxygenase subunit [EC:1.14.13.-] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 398.0 5.0 0.0 1.0 1.0 P 0.0 5.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 5.0 0.0 1.0 1.03745655957765e-12 2.12972890544119e-12 1.58359273250942e-12 1.09227234586354e-12 0 0 0 0 K15063 0.0 0.0142450142450142 ligW; 5-carboxyvanillate decarboxylase path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 308.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 5.0 0.0 1.0 0.0179454885345754 0.0473294049867547 0.032637446760665 0.0293839164521792 0 0 0 0 K15064 0.0 0.0028490028490028 desA; syringate O-demethylase [EC:2.1.1.-] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 475.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 1.0 0.0 1.0 0 0 0 0 K15065 0.0 0.0028490028490028 desZ; 3-O-methylgallate 3,4-dioxygenase [EC:1.13.11.-] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 137.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 1.0 0.0 1.0 0 0 0 0 K15066 0.0 0.0113960113960113 ligM; vanillate/3-O-methylgallate O-demethylase [EC:2.1.1.341] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 467.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 5.0 0.0 1.0 1.59054457389622e-08 4.27869136602673e-06 2.147298405882846e-06 4.262785920287768e-06 0 0 0 0 K15067 0.0285714285714285 0.0341880341880341 amnD; 2-aminomuconate deaminase [EC:3.5.99.5] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 127.0 23.0 0.0 1.0 1.0 J 10.0 13.0 1.0 1.0 COG0251 Enamine_deaminase_RidA,_house_cleaning_of_reactive_enamine_intermediates,_YjgF/YER057c/UK114_family RidA 23.0 0.4347826086956521 0.5652173913043478 0.772455081951528 0.854727031767091 0.8135910568593094 0.0822719498155629 1 1 1 1 K15109 0.0 0.0028490028490028 SLC25A20_29, CACT, CACL, CRC1; solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29 path:map04714 Thermogenesis 335.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2A4JI 1.0 0.0 1.0 0 0 0 0 K15110 0.0 0.0028490028490028 SLC25A21, ODC; solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 253.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DSZY 1.0 0.0 1.0 0 0 0 0 K15125 0.0 0.0 fhaB; filamentous hemagglutinin path:map05133 Pertussis 41.0 29.0 11.0 0.5 U 0.0 0.0 23.0 0.441860465116279 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 0.0 0 0 0 0 K15174 0.0028571428571428 0.0 PAF1; RNA polymerase II-associated factor 1 path:map04011 MAPK signaling pathway - yeast 249.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1971 1.0 1.0 0.0 0 0 0 0 K15176 0.0 0.0028490028490028 CTR9; RNA polymerase-associated protein CTR9 623.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K15179 0.0 0.0028490028490028 WHSC2, NELFA; negative elongation factor A path:map03250 Viral life cycle - HIV-1 318.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3618 Predicted_metal-dependent_hydrolase,_TIM-barrel_fold 1.0 0.0 1.0 0 0 0 0 K15226 0.0 0.0455840455840455 tyrAa; arogenate dehydrogenase (NADP+) [EC:1.3.1.78] path:map00400,path:map01100,path:map01110 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 276.0 16.0 0.0 1.0 1.0 E 0.0 16.0 1.0 1.0 COG0287 Prephenate_dehydrogenase TyrA 16.0 0.0 1.0 0.0007562855020827 0.0038631802779914 0.002309732890037 0.0031068947759087 0 0 0 0 K15228 0.0 0.0113960113960113 mauA; methylamine dehydrogenase light chain [EC:1.4.9.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 126.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 28V8Y 6.0 0.0 1.0 6.94078598551683e-12 0.0594630001128936 0.0297315000599171 0.0594630001059528 0 0 0 0 K15229 0.0 0.0142450142450142 mauB; methylamine dehydrogenase heavy chain [EC:1.4.9.1] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 336.0 5.0 2.0 2.0 0.625 S 0.0 8.0 2.0 0.625 COG3391 DNA-binding_beta-propeller_fold_protein_YncE YncE 8.0 0.0 1.0 0.0148071592041221 0.0236256112387322 0.0192163852214271 0.00881845203461 0 0 0 0 K15230 0.0142857142857142 0.037037037037037 aclA; ATP-citrate lyase alpha-subunit [EC:2.3.3.8] path:map00020,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 583.0 14.0 10.0 2.0 0.777777777777778 C 5.0 13.0 1.0 1.0 COG0074 Succinyl-CoA_synthetase,_alpha_subunit SucD 18.0 0.2777777777777778 0.7222222222222222 0.0439173992124678 0.125191472136239 0.0845544356743533 0.0812740729237711 0 0 0 0 K15231 0.02 0.0398860398860398 aclB; ATP-citrate lyase beta-subunit [EC:2.3.3.8] path:map00020,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 377.0 15.0 9.0 2.0 0.714285714285714 C 7.0 14.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 21.0 0.3333333333333333 0.6666666666666666 0.301073194875031 0.295304867557071 0.298189031216051 0.0057683273179599 0 0 0 0 K15232 0.0171428571428571 0.0284900284900284 ccsA; citryl-CoA synthetase large subunit [EC:6.2.1.18] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 336.0 16.0 0.0 1.0 1.0 C 6.0 10.0 1.0 1.0 COG0045 Succinyl-CoA_synthetase,_beta_subunit SucC 16.0 0.375 0.625 0.0757628782103663 0.0420095297851352 0.0588862039977507 0.0337533484252311 0 0 0 0 K15233 0.0 0.017094017094017 ccsB; citryl-CoA synthetase small subunit path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 302.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG0074 Succinyl-CoA_synthetase,_alpha_subunit SucD 6.0 0.0 1.0 0.0220715047674752 0.0453934748627374 0.0337324898151063 0.0233219700952622 0 0 0 0 K15234 0.0257142857142857 0.0227920227920227 ccl; citryl-CoA lyase [EC:4.1.3.34] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 228.0 18.0 0.0 1.0 1.0 C 10.0 8.0 1.0 1.0 COG0372 Citrate_synthase GltA 18.0 0.5555555555555556 0.4444444444444444 0.0158176559548939 0.977575347077527 0.4966965015162105 0.9617576911226332 0 0 0 0 K15236 0.0 0.0028490028490028 linA; gamma-hexachlorocyclohexane dehydrochlorinase [EC:4.5.1.-] path:map00361,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments 122.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3631 Ketosteroid_isomerase-related_protein YesE 1.0 0.0 1.0 0 0 0 0 K15241 0.0 0.0028490028490028 pcpC; tetrachlorohydroquinone reductive dehalogenase [EC:1.21.4.5] path:map00361,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments 269.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 1.0 0.0 1.0 0 0 0 0 K15242 0.0 0.017094017094017 pcpA; 2,6-dichloro-p-hydroquinone 1,2-dioxygenase [EC:1.13.11.-] path:map00361,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 292.0 6.0 5.0 2.0 0.857142857142857 E 0.0 7.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 7.0 0.0 1.0 0.0463774783230275 0.126463852563535 0.0864206654432812 0.0800863742405075 0 0 0 0 K15255 0.0 0.0199430199430199 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3] 443.0 7.0 0.0 1.0 1.0 L 0.0 7.0 2.0 0.571428571428571 COG0507 ATPase/5-3_helicase_helicase_subunit_RecD_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecD 7.0 0.0 1.0 0.14375897894415 0.375668966547182 0.259713972745666 0.231909987603032 0 0 0 0 K15256 0.1257142857142857 0.282051282051282 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-] 29.0 117.0 98.0 10.0 0.657303370786517 Q 58.0 119.0 10.0 0.623595505617978 COG0500 SAM-dependent_methyltransferase SmtA 177.0 0.327683615819209 0.672316384180791 0.0464062152826661 0.115158742481627 0.0807824788821465 0.0687525271989609 0 0 0 0 K15257 0.0114285714285714 0.1994301994301994 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-] 46.0 26.0 3.0 5.0 0.329113924050633 J 4.0 75.0 6.0 0.341772151898734 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol_methylase UbiG 79.0 0.050632911392405 0.9493670886075948 0.371413948636296 0.764350480506288 0.567882214571292 0.3929365318699919 0 0 0 0 K15266 0.0028571428571428 0.0 TFB1M; dimethyladenosine transferase 1, mitochondrial [EC:2.1.1.-] 272.0 1.0 0.0 1.0 1.0 A 1.0 0.0 1.0 1.0 COG0030 16S_rRNA_A1518_and_A1519_N6-dimethyltransferase_RsmA/KsgA/DIM1_(may_also_have_DNA_glycosylase/AP_lyase_activity) RsmA 1.0 1.0 0.0 0 0 0 0 K15268 0.0057142857142857 0.1139601139601139 eamA; O-acetylserine/cysteine efflux transporter 233.0 46.0 0.0 1.0 1.0 EG 2.0 44.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 46.0 0.0434782608695652 0.9565217391304348 0.0928966486550543 0.0848486750238442 0.0888726618394492 0.00804797363121 0 0 0 0 K15269 0.0 0.074074074074074 pecM; probable blue pigment (indigoidine) exporter 264.0 28.0 27.0 2.0 0.96551724137931 EG 0.0 29.0 2.0 0.96551724137931 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 29.0 0.0 1.0 0.400648187625341 0.622259943846475 0.511454065735908 0.221611756221134 0 0 0 0 K15270 0.0085714285714285 0.1196581196581196 sam; S-adenosylmethionine uptake transporter 217.0 80.0 0.0 1.0 1.0 EG 3.0 77.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 80.0 0.0375 0.9625 0.0021009343169646 0.0284385020005586 0.0152697181587616 0.026337567683594 0 0 0 0 K15271 0.0114285714285714 0.0 HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:5.6.2.4] 65.0 4.0 0.0 1.0 1.0 K 4.0 0.0 1.0 1.0 COG1644 DNA-directed_RNA_polymerase,_subunit_N_(RpoN/RPB10) RPB10 4.0 1.0 0.0 0.0288123931932197 0.0823180331537119 0.0555652131734658 0.0535056399604922 0 0 0 0 K15280 0.0028571428571428 0.0 SLC35C2; solute carrier family 35, member C2 131.0 1.0 0.0 1.0 1.0 EG 1.0 0.0 1.0 1.0 COG0697 Permease_of_the_drug/metabolite_transporter_(DMT)_superfamily RhaT 1.0 1.0 0.0 0 0 0 0 K15303 0.0 0.0056980056980056 AKR7; aflatoxin B1 aldehyde reductase path:map00980 Metabolism of xenobiotics by cytochrome P450 33.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 3.0 0.0 1.0 0 0 0 0 K15311 0.0285714285714285 0.0199430199430199 pksG; polyketide biosynthesis 3-hydroxy-3-methylglutaryl-CoA synthase-like enzyme PksG 375.0 18.0 0.0 1.0 1.0 I 10.0 8.0 1.0 1.0 COG3425 3-hydroxy-3-methylglutaryl_CoA_synthase PksG 18.0 0.5555555555555556 0.4444444444444444 0.0024036422109504 0.0095916708283543 0.0059976565196523 0.0071880286174039 0 0 0 0 K15312 0.0085714285714285 0.0313390313390313 pksH; polyketide biosynthesis enoyl-CoA hydratase PksH 244.0 14.0 0.0 1.0 1.0 I 3.0 11.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 14.0 0.2142857142857142 0.7857142857142857 0.0042906009029179 0.0150814365966313 0.0096860187497746 0.0107908356937134 0 0 0 0 K15313 0.0 0.017094017094017 pksI; polyketide biosynthesis enoyl-CoA hydratase PksI 236.0 6.0 0.0 1.0 1.0 I 0.0 6.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 6.0 0.0 1.0 0.0144708792085189 0.0467830659908525 0.0306269725996857 0.0323121867823336 0 0 0 0 K15314 0.0114285714285714 0.0427350427350427 sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 164.0 18.0 15.0 3.0 0.818181818181818 IQ 4.0 18.0 5.0 0.5 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 22.0 0.1818181818181818 0.8181818181818182 0.0075943655802438 0.0718038513769148 0.0396991084785793 0.064209485796671 0 0 0 0 K15315 0.0 0.0256410256410256 sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10; enediyne core biosynthesis thioesterase path:map01059,path:map01110 Biosynthesis of enediyne antibiotics,Biosynthesis of secondary metabolites 136.0 7.0 5.0 2.0 0.777777777777778 S 0.0 9.0 1.0 1.0 COG0824 Acyl-CoA_thioesterase_FadM FadM 9.0 0.0 1.0 0.0309183585579721 0.262592377395287 0.1467553679766295 0.2316740188373149 0 0 0 0 K15320 0.0 0.0113960113960113 ATX, chlB1, mdpB; 6-methylsalicylic acid synthase [EC:2.3.1.165] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 1307.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 2.0 0.5 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 8.23527667245103e-07 5.63405887268726e-05 2.858205819705885e-05 5.551706105962749e-05 0 0 0 0 K15327 0.0 0.0826210826210826 pksC; polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase 276.0 29.0 0.0 1.0 1.0 I 0.0 29.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 29.0 0.0 1.0 0.001364600328641 0.0142253059589414 0.0077949531437912 0.0128607056303004 0 0 0 0 K15328 0.0 0.0028490028490028 pksD, baeD; bacillaene synthase trans-acting acyltransferase 324.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 1.0 0.0 1.0 0 0 0 0 K15329 0.0 0.0655270655270655 pksE, baeE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains 260.0 21.0 20.0 4.0 0.875 I 0.0 24.0 2.0 0.916666666666667 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 24.0 0.0 1.0 0.0094293178161479 0.0470542324403869 0.0282417751282674 0.037624914624239 0 0 0 0 K15331 0.0 0.0085470085470085 TRMT2B, TRM2; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35] 338.0 2.0 1.0 2.0 0.666666666666667 J 0.0 3.0 1.0 1.0 COG2265 tRNA/tmRNA/rRNA_uracil-C5-methylase,_TrmA/RlmC/RlmD_family TrmA 3.0 0.0 1.0 0 0 0 0 K15333 0.0028571428571428 0.017094017094017 TRM3, TARBP1; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34] 139.0 6.0 5.0 2.0 0.857142857142857 J 1.0 6.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 7.0 0.1428571428571428 0.8571428571428571 0.715776845141171 0.31642244773418 0.5160996464376755 0.399354397406991 0 0 0 1 K15334 0.0257142857142857 0.0 NCL1, TRM4; multisite-specific tRNA:(cytosine-C5)-methyltransferase [EC:2.1.1.202] 513.0 7.0 6.0 3.0 0.777777777777778 A 9.0 0.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 9.0 1.0 0.0 0.0008800836044869 2.85619392465584e-06 0.0004414698992057 0.0008772274105622 0 0 0 0 K15335 0.0085714285714285 0.0 NSUN2, TRM4; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203] 518.0 3.0 0.0 1.0 1.0 J 3.0 0.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 3.0 1.0 0.0 0 0 0 0 K15337 0.0 0.0199430199430199 acpK; polyketide biosynthesis acyl carrier protein 72.0 7.0 6.0 3.0 0.777777777777778 IQ 0.0 9.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 9.0 0.0 1.0 0.0065259460751328 0.0239935036603844 0.0152597248677586 0.0174675575852516 0 0 0 0 K15340 0.0028571428571428 0.0 DCLRE1A, SNM1A, PSO2; DNA cross-link repair 1A protein 303.0 1.0 0.0 1.0 1.0 AL 1.0 0.0 1.0 1.0 COG1236 RNA_processing_exonuclease,_beta-lactamase_fold,_Cft2_family YSH1 1.0 1.0 0.0 0 0 0 0 K15342 0.4285714285714285 0.5042735042735043 cas1; CRISP-associated protein Cas1 74.0 396.0 239.0 2.0 0.716094032549729 L 226.0 315.0 4.0 0.891500904159132 COG1518 CRISPR-Cas_system-associated_integrase_Cas1 Cas1 541.0 0.4177449168207024 0.5822550831792976 0.783669801406037 0.929937073246422 0.8568034373262295 0.146267271840385 1 1 1 1 K15349 0.0 0.0256410256410256 sseJ; secreted effector protein SseJ path:map05132 Salmonella infection 275.0 10.0 0.0 1.0 1.0 I 0.0 10.0 1.0 1.0 COG3240 Phospholipase/lecithinase/hemolysin 10.0 0.0 1.0 0.0047761858251155 0.0581520804186315 0.0314641331218735 0.053375894593516 0 0 0 0 K15352 0.0 0.0056980056980056 pipB2; secreted effector protein PipB2 path:map05132 Salmonella infection 167.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG1357 Uncharacterized_conserved_protein_YjbI,_contains_pentapeptide_repeats YjbI 2.0 0.0 1.0 0 0 0 0 K15353 0.0028571428571428 0.0113960113960113 sspH2; E3 ubiquitin-protein ligase SspH2 path:map05132 Salmonella infection 87.0 6.0 0.0 1.0 1.0 S 2.0 4.0 1.0 1.0 COG4886 Leucine-rich_repeat_(LRR)_protein LRR 6.0 0.3333333333333333 0.6666666666666666 5.9897186029944294e-12 0.103580842288494 0.0517904211472418 0.1035808422825042 0 0 0 0 K15355 0.0 0.0427350427350427 K15355; malonyl CoA-acyl carrier protein transacylase 302.0 15.0 0.0 1.0 1.0 I 0.0 15.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 15.0 0.0 1.0 0.0035025639679656 0.0179795906219417 0.0107410772949536 0.0144770266539761 0 0 0 0 K15357 0.0 0.0313390313390313 nicD; N-formylmaleamate deformylase [EC:3.5.1.106] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 247.0 8.0 6.0 3.0 0.727272727272727 S 0.0 11.0 2.0 0.818181818181818 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 11.0 0.0 1.0 0.0321522662159673 0.217369722625776 0.1247609944208716 0.1852174564098087 0 0 0 0 K15358 0.0085714285714285 0.0256410256410256 ena; enamidase [EC:3.5.2.18] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 374.0 7.0 2.0 3.0 0.538461538461538 F 3.0 10.0 2.0 0.615384615384615 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 13.0 0.2307692307692307 0.7692307692307693 0.20125212169042 0.377297413952394 0.289274767821407 0.176045292261974 0 0 0 0 K15361 0.0028571428571428 0.0 WDR48, UAF1; WD repeat-containing protein 48 path:map03460 Fanconi anemia pathway 295.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0308 1.0 1.0 0.0 0 0 0 0 K15368 0.0 0.0256410256410256 sscA; secretion system chaperone SscA 163.0 10.0 0.0 1.0 1.0 S 0.0 10.0 2.0 0.7 COG1729 Cell_division_protein_CpoB,_coordinates_peptidoglycan_biosynthesis_and_outer_membrane_constriction CpoB 10.0 0.0 1.0 0.0083699975688323 0.0206473589238604 0.0145086782463463 0.0122773613550281 0 0 0 0 K15371 0.0028571428571428 0.1908831908831909 GDH2; glutamate dehydrogenase [EC:1.4.1.2] path:map00220,path:map00250,path:map00430,path:map00910,path:map01100,path:map01120 Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Taurine and hypotaurine metabolism,Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 619.0 72.0 66.0 4.0 0.857142857142857 E 1.0 83.0 4.0 0.904761904761905 COG2902 NAD-specific_glutamate_dehydrogenase Gdh2 84.0 0.0119047619047619 0.988095238095238 0.0032228614526399 0.0082714909594743 0.0057471762060571 0.0050486295068344 0 0 0 0 K15372 0.12 0.0997150997150997 toa; taurine---2-oxoglutarate transaminase [EC:2.6.1.55] path:map00410,path:map00430,path:map01100 beta-Alanine metabolism,Taurine and hypotaurine metabolism,Metabolic pathways 347.0 54.0 20.0 2.0 0.613636363636364 E 52.0 36.0 3.0 0.693181818181818 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 88.0 0.5909090909090909 0.4090909090909091 0.545768361906454 0.823652070372247 0.6847102161393505 0.277883708465793 0 1 0 1 K15373 0.0 0.0085470085470085 isfD; sulfoacetaldehyde reductase [EC:1.1.1.313] path:map00430,path:map01100 Taurine and hypotaurine metabolism,Metabolic pathways 240.0 2.0 1.0 2.0 0.666666666666667 IQ 0.0 3.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 3.0 0.0 1.0 0 0 0 0 K15376 0.0 0.0056980056980056 GPHN; gephyrin [EC:2.10.1.1 2.7.7.75] path:map00790,path:map01100,path:map01240,path:map04727 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,GABAergic synapse 212.0 2.0 0.0 1.0 1.0 H 0.0 2.0 1.0 1.0 COG0303 Molybdopterin_Mo-transferase_(molybdopterin_biosynthesis) MoeA 2.0 0.0 1.0 0 0 0 0 K15383 0.16 0.1452991452991453 K15383; MtN3 and saliva related transmembrane protein 77.0 101.0 0.0 1.0 1.0 S 59.0 56.0 4.0 0.869565217391304 COG4095 Sugar_transporter,_SemiSWEET_family,_contains_PQ_motif SWEET 115.0 0.5130434782608696 0.4869565217391304 0.199576345346673 0.637498410124303 0.418537377735488 0.4379220647776299 0 0 0 0 K15395 0.0 0.0085470085470085 ftdB; hybrid polyketide synthase / nonribosomal peptide synthetase FtdB 956.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 2.0 0.666666666666667 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K15396 0.0028571428571428 0.1367521367521367 trmJ; tRNA (cytidine32/uridine32-2'-O)-methyltransferase [EC:2.1.1.200] 162.0 51.0 0.0 1.0 1.0 J 1.0 50.0 1.0 1.0 COG0565 tRNA_C32,U32_(ribose-2'-O)-methylase_TrmJ_or_a_related_methyltransferase TrmJ 51.0 0.0196078431372549 0.9803921568627452 0.0190830059214745 0.0424864399886206 0.0307847229550475 0.0234034340671461 0 0 0 0 K15408 0.1571428571428571 0.0598290598290598 coxAC; cytochrome c oxidase subunit I+III [EC:7.1.1.9] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 150.0 94.0 0.0 1.0 1.0 C 68.0 25.0 2.0 0.819148936170213 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 93.0 0.7311827956989247 0.2688172043010752 0.691360298118457 0.821333362142071 0.756346830130264 0.1299730640236139 0 1 0 1 K15423 0.0057142857142857 0.0 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] path:map04922 Glucagon signaling pathway 262.0 1.0 0.0 2.0 0.5 GT 2.0 0.0 1.0 1.0 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 2.0 1.0 0.0 0 0 0 0 K15428 0.0114285714285714 0.0 DUG1; Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 443.0 4.0 0.0 1.0 1.0 E 4.0 0.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 4.0 1.0 0.0 1.97683609502354e-21 4.5372486915823397e-13 2.2686243556753506e-13 4.537248671813979e-13 0 0 0 0 K15429 0.9057142857142856 0.0056980056980056 TRM5, TRMT5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] 127.0 298.0 215.0 3.0 0.780104712041885 J 380.0 2.0 3.0 0.994764397905759 COG2520 tRNA_G37_N-methylase_Trm5 Trm5 382.0 0.9947643979057592 0.0052356020942408 0.677594551031251 0.923855703309303 0.800725127170277 0.246261152278052 0 0 0 1 K15431 0.0 0.0056980056980056 phlD; phloroglucinol synthase [EC:2.3.1.253] 349.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG3424 Predicted_naringenin-chalcone_synthase BH0617 2.0 0.0 1.0 0 0 0 0 K15444 0.0057142857142857 0.0028490028490028 TRM9; tRNA (uracil-5-)-methyltransferase TRM9 [EC:2.1.1.229] 196.0 3.0 0.0 1.0 1.0 Q 2.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K15449 0.7714285714285715 0.0 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44] 231.0 271.0 266.0 2.0 0.981884057971014 C 276.0 0.0 1.0 1.0 COG0731 Wyosine_[tRNA(Phe)-imidazoG37]_synthetase,_radical_SAM_superfamily Tyw1 276.0 1.0 0.0 0.120894904545718 0.395009977964 0.257952441254859 0.274115073418282 0 0 0 0 K15450 0.3285714285714285 0.0 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282] 102.0 118.0 106.0 3.0 0.900763358778626 J 131.0 0.0 2.0 0.984732824427481 COG1590 tRNA(Phe)_wybutosine-synthesizing_methylase_Tyw3 Tyw3 131.0 1.0 0.0 0.97983750516845 0.996164758289607 0.9880011317290284 0.016327253121157 0 0 1 1 K15456 0.0028571428571428 0.0 KTI12; protein KTI12 254.0 1.0 0.0 1.0 1.0 F 1.0 0.0 1.0 1.0 COG4088 tRNA_uridine_5-carbamoylmethylation_protein_Kti12_(Killer_toxin_insensitivity_protein) Kti12 1.0 1.0 0.0 0 0 0 0 K15460 0.0028571428571428 0.3276353276353276 yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] 91.0 69.0 38.0 4.0 0.579831932773109 S 1.0 118.0 2.0 0.974789915966386 COG4123 tRNA1(Val)_A37_N6-methylase_TrmN6 TrmN6 119.0 0.0084033613445378 0.9915966386554622 0.0019515473644458 0.0101634868211679 0.0060575170928068 0.0082119394567221 0 0 0 0 K15461 0.0 0.1111111111111111 mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein [EC:2.1.1.61 1.5.-.-] 181.0 24.0 13.0 3.0 0.545454545454545 J 0.0 41.0 2.0 0.772727272727273 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 41.0 0.0 1.0 0.0501180809854799 0.0513426433219817 0.0507303621537308 0.0012245623365017 0 0 0 0 K15466 0.0 0.0085470085470085 rifF, asm9; amide synthase path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 237.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG2162 Arylamine_N-acetyltransferase NhoA 4.0 0.0 1.0 3.06678607712569e-13 8.808349688942069e-13 5.937567883033879e-13 5.74156361181638e-13 0 0 0 0 K15467 0.0057142857142857 0.0 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315] path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 203.0 1.0 0.0 2.0 0.5 M 2.0 0.0 2.0 0.5 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 2.0 1.0 0.0 0 0 0 0 K15468 0.0 0.0313390313390313 pksS, CYP107K1; cytochrome P450 family 107 subfamily K polypeptide 1 362.0 12.0 9.0 2.0 0.8 Q 0.0 15.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 15.0 0.0 1.0 0.0024969778848237 0.0071728972228915 0.0048349375538576 0.0046759193380678 0 0 0 0 K15469 0.0 0.0398860398860398 rhiG; rhizoxin biosynthesis acyltransferase 294.0 14.0 0.0 1.0 1.0 I 0.0 14.0 1.0 1.0 COG0331 Malonyl_CoA-acyl_carrier_protein_transacylase FabD 14.0 0.0 1.0 0.0071773941344724 0.0791553132368323 0.0431663536856523 0.0719779191023599 0 0 0 0 K15471 0.0 0.017094017094017 rhiI; O-methyltransferase [EC:2.1.1.-] 225.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 6.0 0.0 1.0 0.0106324746138172 0.037622004140291 0.0241272393770541 0.0269895295264738 0 0 0 0 K15473 0.0028571428571428 0.017094017094017 sdeA, laiA; effector protein SdeA path:map05134 Legionellosis 94.0 7.0 6.0 2.0 0.875 D 1.0 7.0 1.0 1.0 COG1196 Chromosome_segregation_ATPase_Smc Smc 8.0 0.125 0.875 0.910374915992584 0.38900580706308 0.649690361527832 0.521369108929504 0 0 1 1 K15474 0.0 0.0028490028490028 enhC; enhanced entry protein EnhC path:map05134 Legionellosis 1201.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0790 TPR_repeat TPR 1.0 0.0 1.0 0 0 0 0 K15477 0.0 0.0056980056980056 vipD; VPS inhibitor protein D path:map05134 Legionellosis 21.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG1752 Predicted_acylesterase/phospholipase_RssA,_containd_patatin_domain RssA 4.0 0.0 1.0 1.35921553186117e-12 2.841773191623e-12 2.100494361742085e-12 1.48255765976183e-12 0 0 0 0 K15479 0.0 0.0028490028490028 ralF; guanine nucleotide exchange protein RalF path:map05134 Legionellosis 287.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG5307 Guanine-nucleotide_exchange_factor_YEL1,_contains_Sec7_domain 1.0 0.0 1.0 0 0 0 0 K15481 0.0 0.0056980056980056 lidA; effector protein LidA path:map01120,path:map05134 Microbial metabolism in diverse environments,Legionellosis 569.0 2.0 0.0 1.0 1.0 D 0.0 2.0 1.0 1.0 COG1196 Chromosome_segregation_ATPase_Smc Smc 2.0 0.0 1.0 0 0 0 0 K15482 0.0 0.0056980056980056 sidC; effector protein SidC path:map05134 Legionellosis 475.0 2.0 0.0 1.0 1.0 L 0.0 2.0 2.0 0.5 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 2.0 0.0 1.0 0 0 0 0 K15490 0.0 0.0028490028490028 lgt1_2_3; glucosyltransferase Lgt1/2/3 path:map05134 Legionellosis 545.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2BBGR 1.0 0.0 1.0 0 0 0 0 K15492 0.0 0.0142450142450142 K15492, lepB; effector protein B path:map05134 Legionellosis 531.0 5.0 0.0 1.0 1.0 D 0.0 5.0 2.0 0.8 COG1196 Chromosome_segregation_ATPase_Smc Smc 5.0 0.0 1.0 0.120152053590744 0.197582379894894 0.158867216742819 0.0774303263041499 0 0 0 0 K15495 0.3085714285714285 0.0655270655270655 wtpA; molybdate/tungstate transport system substrate-binding protein path:map02010 ABC transporters 128.0 149.0 0.0 1.0 1.0 P 122.0 27.0 2.0 0.919463087248322 COG0725 ABC-type_molybdate_transport_system,_periplasmic_Mo-binding_protein_ModA ModA 149.0 0.8187919463087249 0.1812080536912751 0.19460021322197 0.951695771875707 0.5731479925488385 0.757095558653737 0 0 0 0 K15496 0.3057142857142857 0.094017094017094 wtpB; molybdate/tungstate transport system permease protein path:map02010 ABC transporters 189.0 149.0 145.0 2.0 0.973856209150327 P 117.0 36.0 3.0 0.928104575163399 COG0555 ABC-type_sulfate_transport_system,_permease_component CysU 153.0 0.7647058823529411 0.2352941176470588 0.807832943684087 0.902354139404672 0.8550935415443794 0.094521195720585 1 1 1 1 K15497 0.3371428571428571 0.0797720797720797 wtpC; molybdate/tungstate transport system ATP-binding protein [EC:7.3.2.5 7.3.2.6] path:map02010 ABC transporters 178.0 96.0 48.0 4.0 0.539325842696629 E 145.0 31.0 4.0 0.758426966292135 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 176.0 0.8238636363636364 0.1761363636363636 0.972546023239478 0.973092563392739 0.9728192933161084 0.0005465401532609 1 1 1 1 K15502 0.0 0.0028490028490028 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 388.0 1.0 0.0 1.0 1.0 Z 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K15503 0.0 0.0227920227920227 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 232.0 3.0 1.0 5.0 0.375 KT 0.0 8.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 8.0 0.0 1.0 0.0110414296479804 0.0295112102862463 0.0202763199671133 0.0184697806382659 0 0 0 0 K15504 0.0 0.0028490028490028 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 388.0 1.0 0.0 1.0 1.0 Z 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K15505 0.0 0.0028490028490028 RAD5; DNA repair protein RAD5 [EC:5.6.2.-] 244.0 1.0 0.0 1.0 1.0 KL 0.0 1.0 1.0 1.0 COG0553 Superfamily_II_DNA_or_RNA_helicase,_SNF2_family HepA 1.0 0.0 1.0 0 0 0 0 K15509 0.0228571428571428 0.0968660968660968 hpsN; sulfopropanediol 3-dehydrogenase [EC:1.1.1.308] 369.0 46.0 44.0 2.0 0.958333333333333 E 8.0 40.0 2.0 0.979166666666667 COG0141 Histidinol_dehydrogenase HisD 48.0 0.1666666666666666 0.8333333333333334 0.954751350212534 0.29964449915151 0.627197924682022 0.6551068510610241 1 1 1 1 K15510 0.0457142857142857 0.0142450142450142 fgd1; coenzyme F420-dependent glucose-6-phosphate dehydrogenase [EC:1.1.98.2] 305.0 27.0 0.0 1.0 1.0 C 20.0 7.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 27.0 0.7407407407407407 0.2592592592592592 0.0065865467052423 0.0339721402181889 0.0202793434617156 0.0273855935129466 0 0 0 0 K15511 0.0 0.0 boxA; benzoyl-CoA 2,3-epoxidase subunit A [EC:1.14.13.208] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 15.0 13.0 3.0 0.833333333333333 C 0.0 0.0 4.0 0.555555555555556 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 0.0 0 0 0 0 K15512 0.0314285714285714 0.0398860398860398 boxB; benzoyl-CoA 2,3-epoxidase subunit B [EC:1.14.13.208] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 355.0 25.0 0.0 1.0 1.0 S 11.0 14.0 1.0 1.0 COG3396 1,2-phenylacetyl-CoA_epoxidase,_catalytic_subunit YdbO 25.0 0.44 0.56 0.016646953225207 0.216782675381218 0.1167148143032125 0.200135722156011 0 0 0 0 K15513 0.0 0.0313390313390313 boxC; benzoyl-CoA-dihydrodiol lyase [EC:4.1.2.44] path:map00362 Benzoate degradation 545.0 11.0 0.0 1.0 1.0 I 0.0 11.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 11.0 0.0 1.0 0.0184034171965689 0.711740387005989 0.3650719021012789 0.6933369698094201 0 0 0 0 K15514 0.0 0.0113960113960113 boxD; 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase [EC:1.2.1.77] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 511.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 4.0 0.0 1.0 0.0213658915758002 0.0354793060962421 0.0284225988360211 0.0141134145204418 0 0 0 0 K15515 0.0028571428571428 0.037037037037037 sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81] path:map00430 Taurine and hypotaurine metabolism 440.0 15.0 14.0 2.0 0.9375 C 1.0 15.0 2.0 0.9375 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 16.0 0.0625 0.9375 0.942242276695268 0.524784950011138 0.733513613353203 0.41745732668413 0 0 1 1 K15518 0.0 0.0626780626780626 dgk; deoxyguanosine kinase [EC:2.7.1.113] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 181.0 22.0 0.0 1.0 1.0 F 0.0 22.0 1.0 1.0 COG1428 Deoxyadenosine/deoxycytidine_kinase Dck 22.0 0.0 1.0 0.0249138456777857 0.151185993957927 0.0880499198178563 0.1262721482801413 0 0 0 0 K15519 0.0057142857142857 0.0569800569800569 dck; deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 138.0 26.0 0.0 1.0 1.0 F 2.0 24.0 2.0 0.923076923076923 COG1428 Deoxyadenosine/deoxycytidine_kinase Dck 26.0 0.0769230769230769 0.9230769230769232 0.921562639586699 0.818102502181258 0.8698325708839785 0.103460137405441 0 0 1 1 K15520 0.0171428571428571 0.1424501424501424 mshD; mycothiol synthase [EC:2.3.1.189] 54.0 51.0 40.0 4.0 0.796875 K 6.0 58.0 4.0 0.71875 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 64.0 0.09375 0.90625 0.0059596949808329 0.0173986245517538 0.0116791597662933 0.0114389295709209 0 0 0 0 K15521 0.0085714285714285 0.1168091168091168 mshA; D-inositol-3-phosphate glycosyltransferase [EC:2.4.1.250] 334.0 36.0 26.0 2.0 0.782608695652174 M 3.0 43.0 2.0 0.739130434782609 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 46.0 0.0652173913043478 0.9347826086956522 0.0047419206472638 0.0127938472944393 0.0087678839708515 0.0080519266471755 0 0 0 0 K15524 0.0228571428571428 0.0826210826210826 mngB; 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate hydrolase [EC:3.2.1.-] 154.0 41.0 34.0 3.0 0.836734693877551 G 8.0 33.0 2.0 0.836734693877551 COG0383 Alpha-mannosidase MngB 41.0 0.1951219512195122 0.8048780487804879 0.0645146783690373 0.893268117890404 0.4788913981297206 0.8287534395213666 0 0 0 0 K15525 0.0 0.0655270655270655 mshB; N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase [EC:3.5.1.103] 250.0 25.0 0.0 1.0 1.0 S 0.0 25.0 1.0 1.0 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 25.0 0.0 1.0 0.0026084128970685 0.006360791572634 0.0044846022348512 0.0037523786755655 0 0 0 0 K15526 0.0971428571428571 0.1367521367521367 mshC; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase [EC:6.3.1.13] 300.0 79.0 75.0 3.0 0.929411764705882 J 35.0 50.0 1.0 1.0 COG0215 Cysteinyl-tRNA_synthetase CysS 85.0 0.4117647058823529 0.5882352941176471 0.986997591377317 0.994327013519811 0.990662302448564 0.0073294221424939 1 1 1 1 K15527 0.0942857142857142 0.017094017094017 K15527; cysteate synthase [EC:2.5.1.76] 340.0 29.0 18.0 2.0 0.725 H 34.0 6.0 1.0 1.0 COG0498 Threonine_synthase ThrC 40.0 0.85 0.15 0.253572055280726 0.5379950002055 0.395783527743113 0.2844229449247739 0 0 0 0 K15531 0.0 0.0341880341880341 rexA; oligosaccharide reducing-end xylanase [EC:3.2.1.156] 311.0 10.0 9.0 4.0 0.769230769230769 G 0.0 13.0 3.0 0.846153846153846 COG3405 Endo-1,4-beta-D-glucanase_Y BcsZ 13.0 0.0 1.0 0.107273663383074 0.229446712952668 0.168360188167871 0.122173049569594 0 0 0 0 K15532 0.0228571428571428 0.0883190883190883 yteR, yesR; unsaturated rhamnogalacturonyl hydrolase [EC:3.2.1.172] 159.0 34.0 26.0 5.0 0.618181818181818 S 9.0 46.0 6.0 0.763636363636364 COG4225 Rhamnogalacturonyl_hydrolase_YesR YesR 55.0 0.1636363636363636 0.8363636363636363 0.0142971265760796 0.0090855068410497 0.0116913167085646 0.0052116197350298 0 0 0 0 K15533 0.0 0.0142450142450142 K15533; 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase [EC:2.4.1.211] 715.0 6.0 5.0 2.0 0.857142857142857 S 0.0 7.0 1.0 1.0 COG5426 Uncharacterized_protein_STM3548,_contains_class_I_glutamine_amidotransferase_domain 7.0 0.0 1.0 0.009308083500039 0.0204542861392746 0.0148811848196568 0.0111462026392356 0 0 0 0 K15534 0.0 0.0028490028490028 K15534; beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase [EC:2.4.1.247] 744.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG5426 Uncharacterized_protein_STM3548,_contains_class_I_glutamine_amidotransferase_domain 1.0 0.0 1.0 0 0 0 0 K15536 0.0 0.0142450142450142 cybC; soluble cytochrome b562 117.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG3783 Soluble_cytochrome_b562 CybC 5.0 0.0 1.0 0.0200041852753422 0.0335911350733818 0.026797660174362 0.0135869497980396 0 0 0 0 K15539 0.0 0.301994301994302 rodZ; cytoskeleton protein RodZ 50.0 86.0 68.0 7.0 0.699186991869919 S 0.0 123.0 7.0 0.813008130081301 COG1426 Cytoskeletal_protein_RodZ,_contains_Xre-like_HTH_and_DUF4115_domains RodZ 123.0 0.0 1.0 0.0082861184241728 0.0333108906003168 0.0207985045122447 0.025024772176144 0 0 0 0 K15540 0.0 0.0113960113960113 ecpD; chaperone protein EcpD 221.0 3.0 1.0 2.0 0.6 M 0.0 5.0 1.0 1.0 COG3121 P_pilus_assembly_protein,_chaperone_PapD FimC 5.0 0.0 1.0 2.88250353945923e-06 5.2219121480491405e-09 1.4438627258036395e-06 2.8772816273111808e-06 0 0 0 0 K15545 0.0028571428571428 0.0313390313390313 mlc; transcriptional regulator of PTS gene 91.0 8.0 4.0 3.0 0.615384615384615 K 1.0 12.0 3.0 0.538461538461538 COG1321 Mn-dependent_transcriptional_regulator_MntR,_DtxR_family MntR 13.0 0.0769230769230769 0.9230769230769232 0.385587736081178 0.198072016429159 0.2918298762551685 0.187515719652019 0 0 0 0 K15546 0.0 0.0484330484330484 boxR, bzdR; XRE family transcriptional regulator, aerobic/anaerobic benzoate catabolism transcriptional regulator 57.0 9.0 3.0 4.0 0.428571428571429 K 0.0 19.0 4.0 0.571428571428571 COG0703 Shikimate_kinase AroK 19.0 0.0 1.0 0.0250040548500294 0.0747377726413755 0.0498709137457024 0.0497337177913461 0 0 0 0 K15547 0.0 0.0113960113960113 mdtO; multidrug resistance protein MdtO 631.0 11.0 10.0 2.0 0.916666666666667 S 0.0 12.0 1.0 1.0 COG1289 Uncharacterized_membrane_protein_YccC YccC 12.0 0.0 1.0 0.0010657897267206 0.0022008154863299 0.0016333026065252 0.0011350257596093 0 0 0 0 K15548 0.0 0.0056980056980056 aaeA; p-hydroxybenzoic acid efflux pump subunit AaeA 310.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG1566 Multidrug_resistance_efflux_pump_EmrA EmrA 2.0 0.0 1.0 0 0 0 0 K15549 0.0 0.017094017094017 mdtN; membrane fusion protein, multidrug efflux system 333.0 13.0 0.0 1.0 1.0 V 0.0 13.0 1.0 1.0 COG1566 Multidrug_resistance_efflux_pump_EmrA EmrA 13.0 0.0 1.0 1.52087853920379e-12 0.0087027225621327 0.0043513612818267 0.0087027225606118 0 0 0 0 K15550 0.0 0.0028490028490028 mdtP; outer membrane protein, multidrug efflux system 394.0 2.0 0.0 1.0 1.0 MU 0.0 2.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 2.0 0.0 1.0 0 0 0 0 K15551 0.0 0.0769230769230769 tauA; taurine transport system substrate-binding protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 271.0 30.0 0.0 1.0 1.0 P 0.0 30.0 2.0 0.866666666666667 COG4521 ABC-type_taurine_transport_system,_periplasmic_component TauA 30.0 0.0 1.0 0.0854942411765362 0.0917982001255489 0.0886462206510425 0.0063039589490127 0 0 0 0 K15552 0.0028571428571428 0.1253561253561253 tauC; taurine transport system permease protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 211.0 48.0 45.0 2.0 0.941176470588235 P 1.0 50.0 1.0 1.0 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 51.0 0.0196078431372549 0.9803921568627452 0.0421511985079622 0.251007477274476 0.146579337891219 0.2088562787665137 0 0 0 0 K15553 0.0028571428571428 0.1396011396011396 ssuA; sulfonate transport system substrate-binding protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 132.0 93.0 0.0 1.0 1.0 P 1.0 92.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 93.0 0.010752688172043 0.989247311827957 0.013384763680636 0.664637931257952 0.339011347469294 0.651253167577316 0 0 0 0 K15554 0.0542857142857142 0.1766381766381766 ssuC; sulfonate transport system permease protein path:map00920,path:map02010 Sulfur metabolism,ABC transporters 200.0 98.0 89.0 2.0 0.91588785046729 P 22.0 85.0 1.0 1.0 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 107.0 0.205607476635514 0.794392523364486 0.0890635701951675 0.756843493637475 0.4229535319163213 0.6677799234423075 0 0 0 0 K15555 0.0114285714285714 0.1994301994301994 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14] path:map00920,path:map02010 Sulfur metabolism,ABC transporters 166.0 100.0 99.0 2.0 0.99009900990099 P 4.0 97.0 2.0 0.99009900990099 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 101.0 0.0396039603960396 0.9603960396039604 0.452448476804676 0.855948812327176 0.654198644565926 0.4035003355225 0 0 0 0 K15558 0.0 0.0085470085470085 ophH; phthalate transport system ATP-binding protein path:map02010 ABC transporters 56.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 3.0 0.0 1.0 0 0 0 0 K15566 0.1085714285714285 0.0028490028490028 trm10; tRNA (adenine9-N1/guanine9-N1)-methyltransferase [EC:2.1.1.218 2.1.1.221] 208.0 38.0 37.0 2.0 0.974358974358974 J 38.0 1.0 1.0 1.0 COG2419 tRNA_(A,G)9-N-methylase_TRM10 TRM10 39.0 0.9743589743589745 0.0256410256410256 0.0050279384788066 0.0076315291360957 0.0063297338074511 0.0026035906572891 0 0 0 0 K15576 0.0057142857142857 0.1452991452991453 nrtA, nasF, cynA; nitrate/nitrite transport system substrate-binding protein path:map00910,path:map02010 Nitrogen metabolism,ABC transporters 292.0 78.0 0.0 1.0 1.0 P 2.0 76.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 78.0 0.0256410256410256 0.9743589743589745 0.0070018106117333 0.0140917548531092 0.0105467827324212 0.0070899442413758 0 0 0 0 K15577 0.0 0.150997150997151 nrtB, nasE, cynB; nitrate/nitrite transport system permease protein path:map00910,path:map02010 Nitrogen metabolism,ABC transporters 197.0 57.0 52.0 4.0 0.876923076923077 P 0.0 65.0 3.0 0.907692307692308 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 65.0 0.0 1.0 0.0089074180681121 0.0134770279334615 0.0111922230007867 0.0045696098653494 0 0 0 0 K15578 0.0 0.1396011396011396 nrtC, nasD; nitrate/nitrite transport system ATP-binding protein [EC:7.3.2.4] path:map00910,path:map02010 Nitrogen metabolism,ABC transporters 234.0 71.0 0.0 1.0 1.0 P 0.0 70.0 2.0 0.859154929577465 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 70.0 0.0 1.0 0.008815858185191 0.294096310324217 0.151456084254704 0.285280452139026 0 0 0 0 K15579 0.0 0.0655270655270655 nrtD, cynD; nitrate/nitrite transport system ATP-binding protein path:map00910,path:map02010 Nitrogen metabolism,ABC transporters 239.0 38.0 0.0 1.0 1.0 P 0.0 38.0 1.0 1.0 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 38.0 0.0 1.0 0.00817831574455 0.0175740885308929 0.0128762021377214 0.0093957727863429 0 0 0 0 K15580 0.0114285714285714 0.3561253561253561 oppA, mppA; oligopeptide transport system substrate-binding protein path:map01501,path:map02010,path:map02024 beta-Lactam resistance,ABC transporters,Quorum sensing 101.0 220.0 204.0 2.0 0.932203389830508 E 4.0 235.0 4.0 0.861924686192469 COG4166 ABC-type_oligopeptide_transport_system,_periplasmic_component OppA 239.0 0.0167364016736401 0.9832635983263598 0.0815222461092828 0.523185717927144 0.3023539820182134 0.4416634718178611 0 0 0 0 K15581 0.0171428571428571 0.3190883190883191 oppB; oligopeptide transport system permease protein path:map01501,path:map02010,path:map02024 beta-Lactam resistance,ABC transporters,Quorum sensing 228.0 104.0 61.0 3.0 0.662420382165605 P 7.0 150.0 1.0 1.0 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 157.0 0.0445859872611464 0.9554140127388536 0.0515895018500623 0.768804245249696 0.4101968735498791 0.7172147433996338 0 0 0 0 K15582 0.0342857142857142 0.3447293447293447 oppC; oligopeptide transport system permease protein path:map01501,path:map02010,path:map02024 beta-Lactam resistance,ABC transporters,Quorum sensing 209.0 107.0 24.0 4.0 0.543147208121827 EP 12.0 185.0 3.0 0.989847715736041 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 197.0 0.0609137055837563 0.9390862944162436 0.927849832966615 0.975180620255028 0.9515152266108216 0.047330787288413 1 1 1 1 K15583 0.1 0.3903133903133903 oppD; oligopeptide transport system ATP-binding protein path:map01501,path:map02010,path:map02024 beta-Lactam resistance,ABC transporters,Quorum sensing 187.0 224.0 163.0 3.0 0.775086505190311 P 42.0 246.0 3.0 0.948096885813149 COG0444 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppD 288.0 0.1458333333333333 0.8541666666666666 0.833790833078463 0.954769504475826 0.8942801687771444 0.1209786713973629 1 1 1 1 K15584 0.0028571428571428 0.0484330484330484 nikA, cntA; nickel transport system substrate-binding protein path:map02010 ABC transporters 441.0 22.0 0.0 1.0 1.0 E 1.0 21.0 1.0 1.0 COG0747 ABC-type_transport_system,_periplasmic_component DdpA 22.0 0.0454545454545454 0.9545454545454546 0.0318679535694813 0.0760950992638207 0.053981526416651 0.0442271456943394 0 0 0 0 K15585 0.0028571428571428 0.0769230769230769 nikB, cntB; nickel transport system permease protein path:map02010 ABC transporters 289.0 21.0 10.0 2.0 0.65625 P 1.0 31.0 1.0 1.0 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 32.0 0.03125 0.96875 0.0614264391451871 0.185111644396481 0.123269041770834 0.1236852052512939 0 0 0 0 K15586 0.0 0.0484330484330484 nikC, cntC; nickel transport system permease protein path:map02010 ABC transporters 266.0 14.0 4.0 3.0 0.56 P 0.0 25.0 1.0 1.0 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 25.0 0.0 1.0 0.0236235193267206 0.0739110999285847 0.0487673096276526 0.0502875806018641 0 0 0 0 K15587 0.0171428571428571 0.0598290598290598 nikD, cntD; nickel transport system ATP-binding protein [EC:7.2.2.11] path:map02010 ABC transporters 173.0 25.0 16.0 2.0 0.735294117647059 P 6.0 28.0 3.0 0.588235294117647 COG0444 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppD 34.0 0.1764705882352941 0.8235294117647058 0.0543031232365761 0.157150989560243 0.1057270563984095 0.1028478663236669 0 0 0 0 K15598 0.0 0.0826210826210826 thiY; putative hydroxymethylpyrimidine transport system substrate-binding protein path:map02010 ABC transporters 275.0 30.0 0.0 1.0 1.0 P 0.0 30.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 30.0 0.0 1.0 0.294975600827927 0.90844949840901 0.6017125496184685 0.613473897581083 0 0 0 0 K15599 0.0028571428571428 0.1025641025641025 thiX; putative hydroxymethylpyrimidine transport system permease protein path:map02010 ABC transporters 229.0 37.0 36.0 2.0 0.973684210526316 P 1.0 37.0 1.0 1.0 COG0600 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_permease_component TauC 38.0 0.0263157894736842 0.9736842105263158 0.142273757049491 0.944115310520747 0.5431945337851191 0.8018415534712561 0 0 0 0 K15600 0.0 0.0455840455840455 thiZ; putative hydroxymethylpyrimidine transport system ATP-binding protein path:map02010 ABC transporters 210.0 16.0 0.0 1.0 1.0 P 0.0 16.0 1.0 1.0 COG1116 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_ATPase_component TauB 16.0 0.0 1.0 0.0560177644159404 0.240826749187027 0.1484222568014837 0.1848089847710866 0 0 0 0 K15629 0.0 0.0512820512820512 CYP152A; fatty-acid peroxygenase [EC:1.11.2.4] 400.0 17.0 16.0 2.0 0.944444444444444 Q 0.0 18.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 18.0 0.0 1.0 0.0017628508969717 0.0045381052176705 0.0031504780573211 0.0027752543206988 0 0 0 0 K15632 0.0 0.0056980056980056 cfr; 23S rRNA (adenine-C8)-methyltransferase [EC:2.1.1.224] 344.0 2.0 0.0 1.0 1.0 J 0.0 2.0 1.0 1.0 COG0820 Adenine_C2-methylase_RlmN_of_23S_rRNA_A2503_and_tRNA_A37 RlmN 2.0 0.0 1.0 0 0 0 0 K15633 0.2314285714285714 0.5783475783475783 gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] path:map00010,path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 369.0 270.0 252.0 3.0 0.918367346938775 G 83.0 211.0 2.0 0.979591836734694 COG0696 Phosphoglycerate_mutase_(BPG-independent),_AlkP_superfamily GpmI 294.0 0.282312925170068 0.717687074829932 0.0028010525068919 0.457653570861119 0.2302273116840054 0.4548525183542271 0 0 0 0 K15634 0.1742857142857143 0.1908831908831909 gpmB; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] path:map00010,path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 51.0 149.0 148.0 4.0 0.980263157894737 G 70.0 82.0 3.0 0.973684210526316 COG0406 Broad_specificity_phosphatase_PhoE PhoE 152.0 0.4605263157894737 0.5394736842105263 0.0423060255447532 0.430279387455447 0.2362927065001001 0.3879733619106938 0 0 0 0 K15635 0.5714285714285714 0.2279202279202279 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] path:map00010,path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 203.0 341.0 331.0 3.0 0.957865168539326 G 252.0 104.0 1.0 1.0 COG3635 2,3-bisphosphoglycerate-independent_phosphoglycerate_mutase,_archeal_type ApgM 356.0 0.7078651685393258 0.2921348314606741 0.0606230281575996 0.900325523562588 0.4804742758600938 0.8397024954049884 0 0 0 0 K15640 0.0285714285714285 0.0541310541310541 K15640, phoE; uncharacterized phosphatase 98.0 30.0 0.0 1.0 1.0 G 10.0 20.0 1.0 1.0 COG0406 Broad_specificity_phosphatase_PhoE PhoE 30.0 0.3333333333333333 0.6666666666666666 0.557520975624167 0.0435762242374668 0.3005485999308169 0.5139447513867003 0 1 0 1 K15641 0.0 0.0113960113960113 mxaF; myxalamid-type polyketide synthase MxaF path:map01052 Type I polyketide structures 643.0 6.0 5.0 2.0 0.857142857142857 IQ 0.0 7.0 3.0 0.714285714285714 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 7.0 0.0 1.0 0.0033621770869083 0.0123301984580828 0.0078461877724955 0.0089680213711745 0 0 0 0 K15642 0.0 0.0056980056980056 mxaD; myxalamid-type polyketide synthase MxaD path:map01052 Type I polyketide structures 1839.0 1.0 0.0 2.0 0.5 IQ 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K15643 0.0 0.0028490028490028 mxaB; myxalamid-type polyketide synthase MxaB path:map01052 Type I polyketide structures 2146.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 1.0 0.0 1.0 0 0 0 0 K15646 0.0 0.0028490028490028 cmaA; coronamic acid synthetase CmaA, adenylation and thiolation didomain protein [EC:6.2.1.46] 2696.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K15650 0.0 0.0056980056980056 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase 233.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 3.0 0.0 1.0 0 0 0 0 K15652 0.0 0.0085470085470085 asbF; 3-dehydroshikimate dehydratase [EC:4.2.1.118] path:map01053,path:map01100,path:map01110 Biosynthesis of siderophore group nonribosomal peptides,Metabolic pathways,Biosynthesis of secondary metabolites 214.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 3.0 0.0 1.0 0 0 0 0 K15653 0.0 0.0142450142450142 mxcG; nonribosomal peptide synthetase MxcG path:map01053 Biosynthesis of siderophore group nonribosomal peptides 695.0 6.0 5.0 2.0 0.857142857142857 Q 0.0 7.0 2.0 0.857142857142857 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 7.0 0.0 1.0 0.0026953998052511 0.0080567703568345 0.0053760850810428 0.0053613705515834 0 0 0 0 K15654 0.0 0.0256410256410256 srfAA, licA, lchAA; surfactin/lichenysin synthetase A path:map01054,path:map02024 Nonribosomal peptide structures,Quorum sensing 429.0 16.0 0.0 1.0 1.0 Q 0.0 14.0 3.0 0.875 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 14.0 0.0 1.0 6.7512278753483e-13 0.0054720429846786 0.0027360214926768 0.0054720429840034 0 0 0 0 K15655 0.0 0.0028490028490028 srfAB, licB, lchAB; surfactin/lichenysin synthetase B path:map01054,path:map02024 Nonribosomal peptide structures,Quorum sensing 203.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K15661 0.0 0.0085470085470085 ituA, mycA, bmyA; iturin family lipopeptide synthetase A path:map01054 Nonribosomal peptide structures 451.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 1.0 1.0 COG0001 Glutamate-1-semialdehyde_aminotransferase HemL 3.0 0.0 1.0 0 0 0 0 K15662 0.0 0.0056980056980056 ituB, mycB, bmyB; iturin family lipopeptide synthetase B path:map01054 Nonribosomal peptide structures 200.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K15664 0.0 0.0113960113960113 ppsA, fenC; plipastatin/fengycin lipopeptide synthetase A path:map01054 Nonribosomal peptide structures 255.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 4.0 0.0 1.0 0.0146515495300741 0.0633123464438912 0.0389819479869826 0.048660796913817 0 0 0 0 K15667 0.0 0.0056980056980056 ppsD, fenA; plipastatin/fengycin lipopeptide synthetase D path:map01054 Nonribosomal peptide structures 201.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K15669 0.0142857142857142 0.150997150997151 hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 30.0 38.0 23.0 6.0 0.567164179104478 JM 6.0 55.0 5.0 0.417910447761194 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 61.0 0.0983606557377049 0.9016393442622952 0.246886271283595 0.711937477171574 0.4794118742275844 0.465051205887979 0 0 0 0 K15670 0.0 0.0028490028490028 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 992.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 1.0 0.0 1.0 0 0 0 0 K15671 0.0457142857142857 0.0085470085470085 rifB; rifamycin polyketide synthase modules 4, 5 and 6 path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 267.0 19.0 18.0 2.0 0.95 H 17.0 3.0 2.0 0.95 COG0373 Glutamyl-tRNA_reductase HemA 20.0 0.85 0.15 0.167488125189389 0.0351866381595721 0.1013373816744805 0.1323014870298169 0 0 0 0 K15672 0.0 0.0085470085470085 rifC_D; rifamycin polyketide synthase modules 7 and 8 path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 32.0 3.0 0.0 1.0 1.0 GM 0.0 3.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 3.0 0.0 1.0 0 0 0 0 K15673 0.0 0.0085470085470085 rifE; rifamycin polyketide synthase modules 9 and 10 path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 161.0 3.0 0.0 1.0 1.0 GM 0.0 3.0 2.0 0.666666666666667 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 3.0 0.0 1.0 0 0 0 0 K15674 0.0 0.017094017094017 rhiA; rhizoxin biosynthesis, polyketide synthase / nonribosomal peptide synthetase RhiA 45.0 4.0 2.0 2.0 0.666666666666667 K 0.0 6.0 4.0 0.5 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 6.0 0.0 1.0 0.0638881932180365 0.137555997670306 0.1007220954441712 0.0736678044522694 0 0 0 0 K15675 0.0 0.0028490028490028 rhiB; rhizoxin biosynthesis, polyketide synthase / nonribosomal peptide synthetase RhiB 861.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K15677 0.0028571428571428 0.0085470085470085 rhiD; rhizoxin biosynthesis, polyketide synthase RhiD 164.0 4.0 0.0 1.0 1.0 Q 1.0 3.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 4.0 0.25 0.75 0.0137069304427967 0.0433429394200018 0.0285249349313992 0.0296360089772051 0 0 0 0 K15681 0.0 0.0113960113960113 mxcL; aminotransferase MxcL path:map01053 Biosynthesis of siderophore group nonribosomal peptides 386.0 4.0 0.0 1.0 1.0 H 0.0 4.0 1.0 1.0 COG0001 Glutamate-1-semialdehyde_aminotransferase HemL 4.0 0.0 1.0 0.0470301291332092 0.110029964510051 0.07853004682163 0.0629998353768418 0 0 0 0 K15706 0.0028571428571428 0.0 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27] 81.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG0800 1.0 1.0 0.0 0 0 0 0 K15717 0.0 0.0028490028490028 PRXL2B, FAM213B; prostamide/prostaglandin F2alpha synthase [EC:1.11.1.20] path:map00590,path:map01100 Arachidonic acid metabolism,Metabolic pathways 182.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 KOG4498 1.0 0.0 1.0 0 0 0 0 K15719 0.0 0.0113960113960113 NCOAT, MGEA5; protein O-GlcNAcase / histone acetyltransferase [EC:3.2.1.169 2.3.1.48] path:map04931 Insulin resistance 315.0 2.0 0.0 2.0 0.5 G 0.0 4.0 2.0 0.5 COG3525 N-acetyl-beta-hexosaminidase Chb 4.0 0.0 1.0 0.0020346580481105 0.0666613611171986 0.0343480095826545 0.0646267030690881 0 0 0 0 K15721 0.0 0.0028490028490028 fyuA; pesticin/yersiniabactin receptor 696.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 1.0 0.0 1.0 0 0 0 0 K15722 0.0 0.0028490028490028 cedA; cell division activator 87.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 2CFPH 1.0 0.0 1.0 0 0 0 0 K15723 0.0 0.0199430199430199 syd; SecY interacting protein Syd 180.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 28Q4G 7.0 0.0 1.0 0.0012404314586534 4.18566830922646e-07 0.0006204250127421 0.0012400128918224 0 0 0 0 K15724 0.1171428571428571 0.1994301994301994 erpA; iron-sulfur cluster insertion protein 78.0 73.0 47.0 3.0 0.634782608695652 S 42.0 73.0 1.0 1.0 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 115.0 0.3652173913043478 0.6347826086956522 0.0240886527655308 0.0094633160129725 0.0167759843892516 0.0146253367525583 0 0 0 0 K15725 0.0 0.2022792022792023 czcC, cusC, cnrC; outer membrane protein, heavy metal efflux system 26.0 142.0 141.0 2.0 0.993006993006993 MU 0.0 143.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 143.0 0.0 1.0 0.0113708075700152 0.0273847093691686 0.0193777584695919 0.0160139017991534 0 0 0 0 K15726 0.0 0.2592592592592592 czcA, cusA, cnrA; heavy metal efflux system protein 864.0 234.0 233.0 2.0 0.995744680851064 P 0.0 235.0 2.0 0.868085106382979 COG3696 Cu/Ag_efflux_pump_CusA CusA 235.0 0.0 1.0 0.0059214783143188 0.198087372582422 0.1020044254483704 0.1921658942681032 0 0 0 0 K15727 0.0 0.3162393162393162 czcB, cusB, cnrB; membrane fusion protein, heavy metal efflux system 60.0 231.0 226.0 2.0 0.978813559322034 M 0.0 235.0 2.0 0.974576271186441 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 235.0 0.0 1.0 0.0278027614975179 0.0895224193565924 0.0586625904270551 0.0617196578590745 0 0 0 0 K15731 0.0 0.0085470085470085 CTDSP; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase [EC:3.1.3.16] 100.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG5190 TFIIF-interacting_CTD_phosphatase,_includes_NLI-interacting_factor FCP1 4.0 0.0 1.0 0.0313263448904478 0.0645171564428738 0.0479217506666607 0.033190811552426 0 0 0 0 K15733 0.0 0.0313390313390313 E1.11.1.19; dye decolorizing peroxidase [EC:1.11.1.19] 357.0 14.0 0.0 1.0 1.0 P 0.0 14.0 1.0 1.0 COG2837 Periplasmic_deferrochelatase/peroxidase_EfeB EfeB 14.0 0.0 1.0 0.0118558761489125 0.0008955664499107 0.0063757212994116 0.0109603096990018 0 0 0 0 K15734 0.0 0.0313390313390313 SDR16C5; all-trans-retinol dehydrogenase (NAD+) [EC:1.1.1.105] path:map00830,path:map01100,path:map01240 Retinol metabolism,Metabolic pathways,Biosynthesis of cofactors 256.0 10.0 7.0 2.0 0.769230769230769 S 0.0 13.0 1.0 1.0 COG0300 Short-chain_dehydrogenase YqjQ 13.0 0.0 1.0 0.0084957202418502 0.0182927675548021 0.0133942438983261 0.0097970473129519 0 0 0 0 K15735 0.0 0.0085470085470085 csiR; GntR family transcriptional regulator, carbon starvation induced regulator 205.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1802 DNA-binding_transcriptional_regulator,_GntR_family GntR 4.0 0.0 1.0 2.60765736584023e-12 0.0407905064992998 0.0203952532509537 0.0407905064966921 0 0 0 0 K15736 0.0857142857142857 0.1396011396011396 lhgO; (S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13] path:map00310,path:map01100,path:map01120 Lysine degradation,Metabolic pathways,Microbial metabolism in diverse environments 299.0 62.0 41.0 2.0 0.746987951807229 S 30.0 53.0 1.0 1.0 COG0579 L-2-hydroxyglutarate_oxidase_LhgO LhgO 83.0 0.3614457831325301 0.6385542168674698 0.202008572464247 0.280618803546109 0.241313688005178 0.078610231081862 0 0 0 0 K15737 0.0 0.0142450142450142 csiD; glutarate dioxygenase [EC:1.14.11.64] path:map00310,path:map01100,path:map01120 Lysine degradation,Metabolic pathways,Microbial metabolism in diverse environments 308.0 3.0 1.0 2.0 0.6 S 0.0 5.0 1.0 1.0 2CG84 5.0 0.0 1.0 0.0764224464938237 0.168504273380013 0.1224633599369183 0.0920818268861893 0 0 0 0 K15738 0.0 0.5726495726495726 uup; ABC transport system ATP-binding/permease protein 416.0 222.0 219.0 3.0 0.973684210526316 S 0.0 228.0 2.0 0.986842105263158 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 228.0 0.0 1.0 0.0017802961796151 0.0039136651623025 0.0028469806709587 0.0021333689826874 0 0 0 0 K15739 0.0 0.017094017094017 vanB, vanA, vanD; D-alanine---(R)-lactate ligase [EC:6.1.2.1] path:map01502,path:map02020 Vancomycin resistance,Two-component system 332.0 5.0 4.0 2.0 0.833333333333333 F 0.0 6.0 1.0 1.0 COG1181 D-alanine-D-alanine_ligase_or_related_ATP-grasp_enzyme DdlA 6.0 0.0 1.0 0.0994223614039079 0.210700263193354 0.1550613122986309 0.1112779017894461 0 0 0 0 K15740 0.0857142857142857 0.0 mptN; tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 243.0 28.0 26.0 2.0 0.933333333333333 H 30.0 0.0 1.0 1.0 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 30.0 1.0 0.0 0.0134260156331879 0.0066944868163366 0.0100602512247622 0.0067315288168512 0 0 0 0 K15745 0.0 0.0056980056980056 AL1; phytoene desaturase (3,4-didehydrolycopene-forming) [EC:1.3.99.30] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 508.0 2.0 0.0 1.0 1.0 H 0.0 2.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 2.0 0.0 1.0 0 0 0 0 K15746 0.02 0.0655270655270655 crtZ; beta-carotene 3-hydroxylase [EC:1.14.15.24] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 128.0 26.0 0.0 1.0 1.0 I 7.0 25.0 2.0 0.8125 COG3000 Sterol_desaturase/sphingolipid_hydroxylase,_fatty_acid_hydroxylase_superfamily ERG3 32.0 0.21875 0.78125 0.0025768613476136 0.0112425979686319 0.0069097296581227 0.0086657366210183 0 0 0 0 K15750 0.0 0.0028490028490028 bphAb, bphA2, bphE; biphenyl 2,3-dioxygenase subunit beta [EC:1.14.12.18] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 176.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K15751 0.0 0.0028490028490028 carAa; carbazole 1,9a-dioxygenase [EC:1.14.12.22] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 401.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 2.0 0.0 1.0 0 0 0 0 K15752 0.0 0.0028490028490028 carAc; carbazole 1,9a-dioxygenase ferredoxin component path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 105.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 1.0 0.0 1.0 0 0 0 0 K15753 0.0 0.0085470085470085 carAd; carbazole 1,9a-dioxygenase ferredoxin reductase component path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 168.0 3.0 0.0 1.0 1.0 C 0.0 3.0 2.0 0.666666666666667 COG0633 Ferredoxin Fdx 3.0 0.0 1.0 0 0 0 0 K15755 0.0 0.0142450142450142 carBb; 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, large subunit [EC:1.13.11.-] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 256.0 6.0 0.0 1.0 1.0 S 0.0 6.0 3.0 0.5 COG2078 Predicted_RNA_modification_protein,_AMMECR1_domain AMMECR1 6.0 0.0 1.0 5.00092745885584e-12 1.02591329133831e-11 7.63003018611947e-12 5.25820545452726e-12 0 0 0 0 K15756 0.0085714285714285 0.0085470085470085 carC; 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase [EC:3.7.1.13] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 235.0 3.0 0.0 2.0 0.5 E 3.0 3.0 2.0 0.5 COG2021 Homoserine_O-acetyltransferase MET2 6.0 0.5 0.5 0.0768343603088932 0.231783144886235 0.1543087525975641 0.1549487845773418 0 0 0 0 K15757 0.0 0.0028490028490028 xylM; toluene methyl-monooxygenase [EC:1.14.15.26] path:map00622,path:map00623,path:map01100,path:map01120,path:map01220 Xylene degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 348.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG3239 Fatty_acid_desaturase DesA 1.0 0.0 1.0 0 0 0 0 K15760 0.0085714285714285 0.0427350427350427 tmoA, tbuA1, touA; toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 32.0 10.0 6.0 4.0 0.526315789473684 T 4.0 15.0 2.0 0.894736842105263 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 19.0 0.2105263157894736 0.7894736842105263 0.0154911449271308 0.279058537756243 0.1472748413416869 0.2635673928291122 0 0 0 0 K15761 0.0 0.0056980056980056 tmoB, tbuU, touB; toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 82.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 2BXCC 2.0 0.0 1.0 0 0 0 0 K15762 0.02 0.0341880341880341 tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit path:map00623,path:map00920,path:map01100,path:map01120,path:map01220 Toluene degradation,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 70.0 20.0 19.0 3.0 0.909090909090909 P 7.0 15.0 2.0 0.909090909090909 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 22.0 0.3181818181818182 0.6818181818181818 0.016798211547324 0.0335620935839142 0.0251801525656191 0.0167638820365902 0 0 0 0 K15763 0.0028571428571428 0.0085470085470085 tmoD, tbuV, touD; toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 96.0 3.0 2.0 2.0 0.75 C 1.0 3.0 3.0 0.5 COG3445 Autonomous_glycyl_radical_cofactor_GrcA GrcA 4.0 0.25 0.75 0.153439243960765 0.254142959444824 0.2037911017027945 0.100703715484059 0 0 0 0 K15764 0.0028571428571428 0.0085470085470085 tmoE, tbuA2, touE; toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-] path:map00623,path:map01100,path:map01120,path:map01220 Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 309.0 2.0 1.0 3.0 0.5 S 1.0 3.0 2.0 0.75 2DB89 4.0 0.25 0.75 0.0756863135311246 0.171933092910456 0.1238097032207903 0.0962467793793314 0 0 0 0 K15765 0.0114285714285714 0.0598290598290598 tmoF, tbuC, touF; toluene monooxygenase electron transfer component [EC:1.18.1.3] path:map00623,path:map00920,path:map01100,path:map01120,path:map01220 Toluene degradation,Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 140.0 29.0 0.0 1.0 1.0 C 4.0 24.0 3.0 0.551724137931035 COG0543 NAD(P)H-flavin_reductase Mcr1 28.0 0.1428571428571428 0.8571428571428571 0.0276129600481965 0.0954780200114757 0.0615454900298361 0.0678650599632792 0 0 0 0 K15770 0.1371428571428571 0.1737891737891738 cycB, ganO, mdxE; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein path:map02010 ABC transporters 114.0 109.0 77.0 5.0 0.746575342465753 G 54.0 87.0 3.0 0.863013698630137 COG2182 Maltose-binding_periplasmic_protein_MalE MalE 141.0 0.3829787234042553 0.6170212765957447 0.434280584373155 0.857034810938938 0.6456576976560464 0.422754226565783 0 0 0 0 K15771 0.1571428571428571 0.2763532763532763 ganP, mdxF; arabinogalactan oligomer / maltooligosaccharide transport system permease protein path:map02010 ABC transporters 99.0 222.0 165.0 4.0 0.730263157894737 P 59.0 245.0 3.0 0.914473684210526 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 304.0 0.194078947368421 0.805921052631579 0.773470747243913 0.779062456840705 0.776266602042309 0.005591709596792 1 1 1 1 K15772 0.1314285714285714 0.1851851851851851 ganQ, mdxG; arabinogalactan oligomer / maltooligosaccharide transport system permease protein path:map02010 ABC transporters 209.0 98.0 72.0 4.0 0.753846153846154 P 49.0 81.0 4.0 0.869230769230769 COG3833 ABC-type_maltose_transport_system,_permease_component_MalG MalG 130.0 0.3769230769230769 0.6230769230769231 0.871961231670095 0.84336108192221 0.8576611567961525 0.0286001497478849 1 1 1 1 K15773 0.0 0.1082621082621082 hipB; HTH-type transcriptional regulator / antitoxin HipB 52.0 44.0 0.0 1.0 1.0 K 0.0 44.0 4.0 0.613636363636364 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 44.0 0.0 1.0 0.0182659144984703 0.0693326287494354 0.0437992716239528 0.051066714250965 0 0 0 0 K15777 0.0742857142857142 0.2193732193732193 DOPA; 4,5-DOPA dioxygenase extradiol [EC:1.13.11.-] path:map00965,path:map01110 Betalain biosynthesis,Biosynthesis of secondary metabolites 156.0 92.0 79.0 3.0 0.779661016949153 S 32.0 86.0 1.0 1.0 COG3384 Aromatic_ring-opening_dioxygenase,_catalytic_subunit,_LigB_family LigB 118.0 0.2711864406779661 0.7288135593220338 0.0739701818587922 0.461589331193229 0.2677797565260106 0.3876191493344367 0 0 0 0 K15778 0.7571428571428571 0.3361823361823361 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2] path:map00010,path:map00030,path:map00051,path:map00052,path:map00230,path:map00500,path:map00520,path:map00521,path:map01100,path:map01110,path:map01120,path:map01250 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Galactose metabolism,Purine metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Streptomycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of nucleotide sugars 215.0 441.0 433.0 6.0 0.967105263157895 G 305.0 150.0 2.0 0.99780701754386 COG1109 Phosphomannomutase ManB 455.0 0.6703296703296703 0.3296703296703296 0.665733689312292 0.901660159213314 0.783696924262803 0.2359264699010219 0 1 0 1 K15780 0.0028571428571428 0.1168091168091168 tilS-hprT; bifunctional protein TilS/HprT [EC:6.3.4.19 2.4.2.8] path:map00230,path:map01100,path:map01110,path:map01232 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism 93.0 31.0 1.0 4.0 0.46969696969697 F 1.0 65.0 2.0 0.53030303030303 COG0037 tRNA(Ile)-lysidine_synthase_TilS/MesJ TilS 66.0 0.0151515151515151 0.9848484848484848 0.0116934488440968 0.0346935159073885 0.0231934823757426 0.0230000670632916 0 0 0 0 K15781 0.0028571428571428 0.0313390313390313 serB-plsC; putative phosphoserine phosphatase / 1-acylglycerol-3-phosphate O-acyltransferase [EC:3.1.3.3 2.3.1.51] 14.0 6.0 2.0 3.0 0.5 EI 1.0 11.0 2.0 0.833333333333333 COG0204 1-acyl-sn-glycerol-3-phosphate_acyltransferase PlsC 12.0 0.0833333333333333 0.9166666666666666 0.0972891273885914 0.0989433498012436 0.0981162385949175 0.0016542224126522 0 0 0 0 K15782 0.0 0.0227920227920227 doeX; Lrp/AsnC family transcriptional regulator, regulator of ectoine-degradation genes 158.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 10.0 0.0 1.0 0.0038354539573981 0.0077877260324031 0.0058115899949006 0.003952272075005 0 0 0 0 K15783 0.0028571428571428 0.0569800569800569 doeA; ectoine hydrolase [EC:3.5.4.44] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 275.0 23.0 0.0 1.0 1.0 E 1.0 22.0 2.0 0.826086956521739 COG0006 Xaa-Pro_aminopeptidase PepP 23.0 0.0434782608695652 0.9565217391304348 0.0182568142384659 0.0467819221038946 0.0325193681711802 0.0285251078654287 0 0 0 0 K15784 0.0057142857142857 0.0256410256410256 doeB; N2-acetyl-L-2,4-diaminobutanoate deacetylase [EC:3.5.1.125] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 324.0 11.0 0.0 1.0 1.0 S 2.0 9.0 1.0 1.0 COG3608 Predicted_deacylase 11.0 0.1818181818181818 0.8181818181818182 0.0390706055148385 0.0937793348554184 0.0664249701851284 0.0547087293405798 0 0 0 0 K15785 0.0 0.0398860398860398 doeD; L-2,4-diaminobutyrate transaminase [EC:2.6.1.76] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 455.0 8.0 0.0 2.0 0.5 H 0.0 16.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 16.0 0.0 1.0 0.0117204988984076 0.0288016362898606 0.0202610675941341 0.0170811373914529 0 0 0 0 K15786 0.0 0.0227920227920227 doeC; aspartate-semialdehyde dehydrogenase [EC:1.2.1.-] path:map00260,path:map01100,path:map01120 Glycine, serine and threonine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 482.0 9.0 0.0 1.0 1.0 C 0.0 9.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 9.0 0.0 1.0 0.030213995748646 0.0596021512926985 0.0449080735206722 0.0293881555440525 0 0 0 0 K15789 0.0028571428571428 0.0 TDH; threonine 3-dehydrogenase [EC:1.1.1.103] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 322.0 1.0 0.0 1.0 1.0 GM 1.0 0.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 1.0 1.0 0.0 0 0 0 0 K15790 0.0 0.0398860398860398 nifQ; nitrogen fixation protein NifQ 147.0 12.0 10.0 2.0 0.857142857142857 S 0.0 14.0 3.0 0.785714285714286 2BDS5 14.0 0.0 1.0 0.0271684517640457 0.0753239137332058 0.0512461827486257 0.04815546196916 0 0 0 0 K15792 0.0 0.1595441595441595 murEF; MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10] path:map00300,path:map00550,path:map01100 Lysine biosynthesis,Peptidoglycan biosynthesis,Metabolic pathways 242.0 63.0 61.0 2.0 0.969230769230769 M 0.0 65.0 2.0 0.646153846153846 COG0769 UDP-N-acetylmuramyl_tripeptide_synthase MurE 65.0 0.0 1.0 0.90104175369612 0.955293748504604 0.928167751100362 0.0542519948084839 0 0 1 1 K15827 0.0 0.0199430199430199 hycB; formate hydrogenlyase subunit 2 147.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 7.0 0.0 1.0 0.0722066253524794 0.153414680578986 0.1128106529657327 0.0812080552265065 0 0 0 0 K15828 0.0 0.0085470085470085 hycC; formate hydrogenlyase subunit 3 535.0 4.0 0.0 1.0 1.0 CP 0.0 4.0 1.0 1.0 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 4.0 0.0 1.0 8.27962002410693e-12 0.123463753994376 0.0617318770013278 0.1234637539860963 0 0 0 0 K15829 0.0171428571428571 0.0056980056980056 hycD; formate hydrogenlyase subunit 4 288.0 9.0 0.0 1.0 1.0 C 6.0 3.0 1.0 1.0 COG0650 Formate_hydrogenlyase_subunit_HyfC HyfC 9.0 0.6666666666666666 0.3333333333333333 0.0195334577008893 0.0425336780941166 0.0310335678975029 0.0230002203932273 0 0 0 0 K15830 0.0057142857142857 0.0284900284900284 hycE; formate hydrogenlyase subunit 5 23.0 14.0 0.0 1.0 1.0 C 3.0 11.0 2.0 0.642857142857143 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 14.0 0.2142857142857142 0.7857142857142857 0.327580333211351 0.341245867348201 0.334413100279776 0.01366553413685 0 0 0 0 K15831 0.0342857142857142 0.0227920227920227 hycF; formate hydrogenlyase subunit 6 104.0 20.0 0.0 1.0 1.0 C 12.0 8.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 20.0 0.6 0.4 0.0544966155958595 0.318982438147845 0.1867395268718522 0.2644858225519855 0 0 0 0 K15832 0.0457142857142857 0.0085470085470085 hycG; formate hydrogenlyase subunit 7 124.0 20.0 0.0 1.0 1.0 C 16.0 4.0 1.0 1.0 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 20.0 0.8 0.2 0.0329415169227055 0.0362878559241694 0.0346146864234374 0.0033463390014639 0 0 0 0 K15833 0.0 0.0056980056980056 hycA; formate hydrogenlyase regulatory protein HycA 113.0 1.0 0.0 1.0 1.0 K 0.0 2.0 2.0 0.5 2C05Z 2.0 0.0 1.0 0 0 0 0 K15834 0.0 0.0113960113960113 hycH; formate hydrogenlyase maturation protein HycH 106.0 2.0 1.0 3.0 0.5 E 0.0 4.0 2.0 0.75 2DBX5 4.0 0.0 1.0 0.0664653432333628 0.174850944131523 0.1206581436824429 0.1083856008981602 0 0 0 0 K15835 0.0 0.0113960113960113 murR; RpiR family transcriptional regulator, murPQ operon repressor 283.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1737 DNA-binding_transcriptional_regulator,_MurR/RpiR_family,_contains_HTH_and_SIS_domains RpiR 6.0 0.0 1.0 1.06106900064231e-05 0.0047420795350293 0.0023763451125178 0.0047314688450228 0 0 0 0 K15836 0.0028571428571428 0.0484330484330484 fhlA; formate hydrogenlyase transcriptional activator 274.0 20.0 5.0 2.0 0.571428571428571 KT 1.0 34.0 4.0 0.342857142857143 COG3604 FhlA-type_transcriptional_regulator,_contains_GAF,_AAA-type_ATPase,_and_DNA-binding_Fis_domains FhlA 35.0 0.0285714285714285 0.9714285714285714 0.0030589922202098 0.00549977434076 0.0042793832804849 0.0024407821205502 0 0 0 0 K15842 0.0057142857142857 0.0056980056980056 cagA; cytotoxicity-associated immunodominant antigen path:map05120 Epithelial cell signaling in Helicobacter pylori infection 362.0 3.0 2.0 2.0 0.75 GM 2.0 2.0 2.0 0.75 COG0673 Predicted_dehydrogenase MviM 4.0 0.5 0.5 0.104512617491504 0.245392407457823 0.1749525124746635 0.140879789966319 0 0 0 0 K15850 0.0 0.0056980056980056 luxN; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-] path:map02020,path:map02024 Two-component system,Quorum sensing 480.0 3.0 0.0 1.0 1.0 T 0.0 3.0 2.0 0.666666666666667 COG0642 Signal_transduction_histidine_kinase BaeS 3.0 0.0 1.0 0 0 0 0 K15852 0.0 0.017094017094017 luxR, vanR; LuxR family transcriptional regulator, transcriptional activator of the bioluminescence operon path:map02024 Quorum sensing 203.0 6.0 0.0 1.0 1.0 K 0.0 6.0 2.0 0.666666666666667 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 6.0 0.0 1.0 0.0341159732127795 0.0784198700386168 0.0562679216256981 0.0443038968258373 0 0 0 0 K15853 0.0 0.017094017094017 luxD; acyl transferase [EC:2.3.1.-] path:map02020,path:map02024 Two-component system,Quorum sensing 237.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 6.0 0.0 1.0 0.293958937459192 0.178485717196861 0.2362223273280265 0.115473220262331 0 0 0 0 K15854 0.0 0.0056980056980056 luxB; alkanal monooxygenase beta chain [EC:1.14.14.3] path:map02020,path:map02024 Two-component system,Quorum sensing 304.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 2.0 0.0 1.0 0 0 0 0 K15855 0.0057142857142857 0.0256410256410256 csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 510.0 13.0 0.0 1.0 1.0 G 2.0 11.0 1.0 1.0 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 13.0 0.1538461538461538 0.8461538461538461 0.0413122082164432 0.0822412953194666 0.0617767517679549 0.0409290871030234 0 0 0 0 K15856 0.0428571428571428 0.1196581196581196 rmd; GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281] path:map00051,path:map00520,path:map00541,path:map01100,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 214.0 53.0 39.0 2.0 0.791044776119403 M 17.0 50.0 2.0 0.656716417910448 COG1089 GDP-D-mannose_dehydratase Gmd 67.0 0.2537313432835821 0.746268656716418 0.0652396346742878 0.923217349557821 0.4942284921160544 0.8579777148835331 0 0 0 0 K15861 0.0 0.0256410256410256 fixK; CRP/FNR family transcriptional regulator, nitrogen fixation regulation protein path:map02020 Two-component system 185.0 9.0 8.0 2.0 0.9 K 0.0 10.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 10.0 0.0 1.0 0.0062912729522058 0.0699885809893779 0.0381399269707918 0.063697308037172 0 0 0 0 K15862 0.0028571428571428 0.1054131054131054 ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9] path:map00190,path:map01100,path:map02020 Oxidative phosphorylation,Metabolic pathways,Two-component system 436.0 41.0 39.0 2.0 0.953488372093023 C 1.0 42.0 3.0 0.674418604651163 COG2993 Cbb3-type_cytochrome_oxidase,_cytochrome_c_subunit_FixO CcoO 43.0 0.0232558139534883 0.9767441860465116 0.0142011117227489 0.0572164868579601 0.0357087992903545 0.0430153751352112 0 0 0 0 K15863 0.0371428571428571 0.0 nuoLM; NADH-quinone oxidoreductase subunit L/M [EC:7.1.1.2] path:map00190,path:map01100 Oxidative phosphorylation,Metabolic pathways 452.0 12.0 11.0 2.0 0.923076923076923 C 13.0 0.0 1.0 1.0 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 13.0 1.0 0.0 0.0077659108712278 0.0293887891175005 0.0185773499943641 0.0216228782462727 0 0 0 0 K15864 0.0428571428571428 0.037037037037037 nirS; nitrite reductase (NO-forming) / hydroxylamine reductase [EC:1.7.2.1 1.7.99.1] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 52.0 34.0 0.0 1.0 1.0 C 18.0 14.0 3.0 0.470588235294118 COG1622 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_2 CyoA 32.0 0.5625 0.4375 0.133855555660557 0.0450337275551696 0.0894446416078633 0.0888218281053874 0 0 0 0 K15865 0.6428571428571429 0.0113960113960113 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5] 244.0 236.0 0.0 1.0 1.0 J 232.0 4.0 1.0 1.0 COG0621 tRNA_A37_methylthiotransferase_MiaB MiaB 236.0 0.9830508474576272 0.0169491525423728 0.977355127655826 0.924817948056638 0.951086537856232 0.052537179599188 1 1 1 1 K15866 0.1428571428571428 0.2735042735042735 paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18] path:map00360,path:map01100,path:map01120 Phenylalanine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 154.0 230.0 229.0 2.0 0.995670995670996 I 70.0 161.0 3.0 0.982683982683983 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 231.0 0.303030303030303 0.696969696969697 0.0227005006354627 0.01130567048446 0.0170030855599613 0.0113948301510026 0 0 0 0 K15868 0.0 0.0056980056980056 baiB; bile acid-coenzyme A ligase [EC:6.2.1.7] path:map00121 Secondary bile acid biosynthesis 470.0 4.0 0.0 1.0 1.0 IQ 0.0 4.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 4.0 0.0 1.0 3.90149044869031e-13 1.3614820316716599e-12 8.758155382703455e-13 9.713329868026292e-13 0 0 0 0 K15876 0.0057142857142857 0.1253561253561253 nrfH; cytochrome c nitrite reductase small subunit path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 37.0 63.0 0.0 1.0 1.0 C 4.0 59.0 2.0 0.888888888888889 COG3005 Tetraheme_cytochrome_c_subunit_NapC_of_nitrate_or_TMAO_reductase NapC 63.0 0.0634920634920634 0.9365079365079364 0.0317494898449078 0.159520145996503 0.0956348179207054 0.1277706561515952 0 0 0 0 K15878 0.0428571428571428 0.0113960113960113 K15878, narB; rieske iron-sulfur protein 169.0 22.0 0.0 1.0 1.0 C 17.0 5.0 1.0 1.0 COG0723 Rieske_Fe-S_protein QcrA/PetC 22.0 0.7727272727272727 0.2272727272727272 0.0150132108403335 0.135228880965875 0.0751210459031042 0.1202156701255414 0 0 0 0 K15879 0.08 0.0199430199430199 narC; cytochrome b-561 308.0 41.0 0.0 1.0 1.0 C 34.0 7.0 1.0 1.0 COG1290 Cytochrome_b_subunit_of_the_bc_complex QcrB/PetB 41.0 0.8292682926829268 0.1707317073170731 0.0523661689620084 0.334279903537586 0.1933230362497972 0.2819137345755776 0 0 0 0 K15885 0.0 0.0113960113960113 mtmQ; C7-C12 aromatase (ARO/CYC) [EC:4.2.1.-] path:map01056,path:map01100,path:map01110 Biosynthesis of type II polyketide backbone,Metabolic pathways,Biosynthesis of secondary metabolites 131.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG2867 Ribosome_association_toxin_PasT_(RatA)_of_the_RatAB_toxin-antitoxin_module PasT 4.0 0.0 1.0 8.22958059983037e-13 2.15919239760293e-08 1.079637346704464e-08 2.159110101796932e-08 0 0 0 0 K15886 0.0 0.0056980056980056 tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235] path:map01056,path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide backbone,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 142.0 1.0 0.0 2.0 0.5 I 0.0 2.0 2.0 0.5 COG2867 Ribosome_association_toxin_PasT_(RatA)_of_the_RatAB_toxin-antitoxin_module PasT 2.0 0.0 1.0 0 0 0 0 K15888 0.8257142857142857 0.0142450142450142 uppS, cpdS; tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific] [EC:2.5.1.89] path:map00900 Terpenoid backbone biosynthesis 160.0 312.0 0.0 1.0 1.0 H 307.0 5.0 1.0 1.0 COG0020 Undecaprenyl_pyrophosphate_synthase UppS 312.0 0.9839743589743588 0.016025641025641 0.764970634949511 0.543914418817411 0.654442526883461 0.2210562161321 1 1 1 1 K15891 0.0057142857142857 0.0 FLDH; NAD+-dependent farnesol dehydrogenase [EC:1.1.1.354] path:map00900,path:map00909,path:map01110 Terpenoid backbone biosynthesis,Sesquiterpenoid and triterpenoid biosynthesis,Biosynthesis of secondary metabolites 310.0 2.0 0.0 1.0 1.0 V 2.0 0.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 2.0 1.0 0.0 0 0 0 0 K15892 0.0057142857142857 0.0 FOLK; farnesol kinase [EC:2.7.1.216] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 175.0 2.0 0.0 1.0 1.0 K 2.0 0.0 1.0 1.0 COG0170 Dolichol_kinase SEC59 2.0 1.0 0.0 0 0 0 0 K15893 0.0 0.0455840455840455 HPR1; glycerate dehydrogenase [EC:1.1.1.29] path:map00260,path:map00630,path:map01100,path:map01110,path:map01120,path:map01200 Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 309.0 9.0 4.0 4.0 0.5625 CH 0.0 16.0 2.0 0.9375 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 16.0 0.0 1.0 0.0390142335257649 0.110836415830143 0.0749253246779539 0.0718221823043781 0 0 0 0 K15894 0.04 0.1965811965811965 pseB, wbjB; UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase [EC:4.2.1.115 5.1.3.-] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 214.0 65.0 34.0 3.0 0.670103092783505 M 17.0 80.0 3.0 0.969072164948454 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 97.0 0.1752577319587628 0.8247422680412371 0.429829142650615 0.82211791614177 0.6259735293961926 0.392288773491155 0 0 0 0 K15895 0.0 0.0085470085470085 pseC; UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine transaminase [EC:2.6.1.92] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 340.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 4.0 0.0 1.0 7.61381254016581e-07 1.3363752434816e-05 7.06256684441629e-06 1.260237118079942e-05 0 0 0 0 K15896 0.0057142857142857 0.0313390313390313 pseH; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase [EC:2.3.1.202] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 127.0 7.0 0.0 3.0 0.466666666666667 M 2.0 13.0 3.0 0.666666666666667 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 15.0 0.1333333333333333 0.8666666666666667 0.0806433362092951 0.160201822804129 0.120422579506712 0.0795584865948339 0 0 0 0 K15897 0.0171428571428571 0.0541310541310541 pseG; UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase [EC:3.6.1.57] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 171.0 25.0 0.0 1.0 1.0 M 6.0 19.0 3.0 0.8 COG3980 Spore_coat_polysaccharide_biosynthesis_protein_SpsG,_predicted_glycosyltransferase SpsG 25.0 0.24 0.76 0.0601421934017084 0.114601797155609 0.0873719952786587 0.0544596037539006 0 0 0 0 K15898 0.0485714285714285 0.1111111111111111 pseI, neuB3; pseudaminic acid synthase [EC:2.5.1.97] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 269.0 63.0 61.0 2.0 0.969230769230769 M 19.0 46.0 5.0 0.861538461538462 COG2089 Sialic_acid_synthase_SpsE,_contains_C-terminal_SAF_domain SpsE 65.0 0.2923076923076923 0.7076923076923077 0.1279885522578 0.170062506516854 0.149025529387327 0.042073954259054 0 0 0 0 K15899 0.0 0.0227920227920227 pseF; pseudaminic acid cytidylyltransferase [EC:2.7.7.81] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 224.0 8.0 0.0 1.0 1.0 M 0.0 8.0 1.0 1.0 COG1083 CMP-N-acetylneuraminic_acid_synthetase,_NeuA/PseF_family NeuA 8.0 0.0 1.0 0.0621759377370526 0.124351671611528 0.0932638046742903 0.0621757338744754 0 0 0 0 K15901 0.0028571428571428 0.0 TPRKB, CGI121; EKC/KEOPS complex subunit TPRKB/CGI121 193.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 KOG4066 1.0 1.0 0.0 0 0 0 0 K15904 0.0 0.0 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32 [EC:2.3.1.234 2.7.11.1] 95.0 36.0 4.0 0.477386934673367 LT 0.0 0.0 1.0 1.0 COG0533 tRNA_A37_threonylcarbamoyltransferase_TsaD TsaD 0.0 0 0 0 0 K15907 0.0 0.0028490028490028 ptlI, CYP183A; pentalenene oxygenase [EC:1.14.15.32] path:map00909,path:map00998,path:map01100,path:map01110 Sesquiterpenoid and triterpenoid biosynthesis,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 428.0 2.0 0.0 2.0 0.5 Q 0.0 4.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 4.0 0.0 1.0 8.42946604070316e-08 2.31938707785105e-18 4.214733020467549e-08 8.429466040471222e-08 0 0 0 0 K15910 0.0 0.0113960113960113 pglE; UDP-N-acetylbacillosamine transaminase [EC:2.6.1.34] path:map00520,path:map01250 Amino sugar and nucleotide sugar metabolism,Biosynthesis of nucleotide sugars 297.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 4.0 0.0 1.0 0.0662456289844146 0.142969371003616 0.1046074999940153 0.0767237420192014 0 0 0 0 K15911 0.0 0.0028490028490028 E2.5.1.153; adenosine tuberculosinyltransferase [EC:2.5.1.153] 289.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28XHJ 1.0 0.0 1.0 0 0 0 0 K15912 0.0 0.0256410256410256 pglF; UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135] path:map00520,path:map00541,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 378.0 9.0 0.0 1.0 1.0 GM 0.0 9.0 1.0 1.0 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 9.0 0.0 1.0 0.855433160425616 0.429285206179423 0.6423591833025195 0.426147954246193 0 0 1 1 K15913 0.0 0.0056980056980056 pglD; UDP-N-acetylbacillosamine N-acetyltransferase [EC:2.3.1.203] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 197.0 1.0 0.0 2.0 0.5 GM 0.0 2.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 2.0 0.0 1.0 0 0 0 0 K15914 0.0028571428571428 0.0056980056980056 pglA; N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase [EC:2.4.1.290] 374.0 3.0 0.0 1.0 1.0 M 1.0 2.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K15915 0.0 0.0512820512820512 pglC; undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase [EC:2.7.8.36] 201.0 20.0 0.0 1.0 1.0 M 0.0 20.0 1.0 1.0 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 20.0 0.0 1.0 0.293746503100798 0.0282709318326944 0.1610087174667462 0.2654755712681035 0 0 0 0 K15916 0.3514285714285714 0.2336182336182336 pgi-pmi; glucose/mannose-6-phosphate isomerase [EC:5.3.1.9 5.3.1.8] path:map00010,path:map00030,path:map00051,path:map00500,path:map00520,path:map01100,path:map01110,path:map01120,path:map01200,path:map01250 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of nucleotide sugars 99.0 123.0 55.0 3.0 0.572093023255814 G 132.0 83.0 5.0 0.553488372093023 COG2222 Fructoselysine-6-P-deglycase_FrlB_or_related_protein,_duplicated_sugar_isomerase_(SIS)_domain AgaS 215.0 0.6139534883720931 0.386046511627907 0.174999159684067 0.63440935189238 0.4047042557882235 0.459410192208313 0 0 0 0 K15918 0.0028571428571428 0.0826210826210826 GLYK; D-glycerate 3-kinase [EC:2.7.1.31] path:map00260,path:map00561,path:map00630,path:map01100,path:map01110,path:map01200 Glycine, serine and threonine metabolism,Glycerolipid metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 123.0 34.0 0.0 1.0 1.0 S 1.0 33.0 2.0 0.705882352941177 COG4240 Pantothenate_kinase-related_protein_Tda10_(topoisomerase_I_damage_affected_protein) Tda10 34.0 0.0294117647058823 0.9705882352941176 0.0074166678623912 0.0171565988520194 0.0122866333572053 0.0097399309896282 0 0 0 0 K15920 0.0028571428571428 0.0 XYL4; xylan 1,4-beta-xylosidase [EC:3.2.1.37] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 419.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 KOG4157 1.0 1.0 0.0 0 0 0 0 K15921 0.0 0.0341880341880341 xynD; arabinoxylan arabinofuranohydrolase [EC:3.2.1.55] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 202.0 12.0 10.0 3.0 0.8 G 0.0 15.0 2.0 0.8 COG3507 Beta-xylosidase XynB2 15.0 0.0 1.0 0.0722322586247726 0.188125224282713 0.1301787414537428 0.1158929656579404 0 0 0 0 K15922 0.0 0.0256410256410256 yihQ; sulfoquinovosidase [EC:3.2.1.199] 534.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG1501 Alpha-glucosidase/xylosidase,_GH31_family YicI 9.0 0.0 1.0 0.124565254295961 0.026268343943717 0.075416799119839 0.098296910352244 0 0 0 0 K15923 0.02 0.131054131054131 AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51] path:map00511 Other glycan degradation 347.0 74.0 63.0 5.0 0.804347826086956 G 7.0 85.0 11.0 0.695652173913044 COG1554 Kojibiose_phosphorylase_YcjT ATH1 92.0 0.0760869565217391 0.9239130434782608 0.0141029544221851 0.0574390527902979 0.0357710036062415 0.0433360983681128 0 0 0 0 K15924 0.0057142857142857 0.0455840455840455 xynC; glucuronoarabinoxylan endo-1,4-beta-xylanase [EC:3.2.1.136] 128.0 10.0 3.0 6.0 0.384615384615385 M 2.0 24.0 11.0 0.230769230769231 COG5520 O-Glycosyl_hydrolase XynC 26.0 0.0769230769230769 0.9230769230769232 0.0070615230938833 0.0359131189214765 0.0214873210076799 0.0288515958275932 0 0 0 0 K15926 0.0 0.0113960113960113 jadI; cyclase path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 103.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2C9N8 4.0 0.0 1.0 0.0083167181356011 0.0266376923607835 0.0174772052481923 0.0183209742251824 0 0 0 0 K15927 0.0 0.0028490028490028 jadF; oxygenase path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 503.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K15928 0.0 0.0028490028490028 jadH; bifunctional hydroxylase/dehydrase path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 489.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K15929 0.0 0.0028490028490028 jadS; glycosyltransferase [EC:2.4.1.-] path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 393.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K15930 0.0 0.0028490028490028 lndM2; bifunctional oxygenase/reductase path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 503.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K15941 0.0 0.0028490028490028 snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 100.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2329 Heme-degrading_monooxygenase_HmoA_and_related_ABM_domain_proteins HmoA 1.0 0.0 1.0 0 0 0 0 K15942 0.0 0.0142450142450142 snoaC, dnrC, dauC, aknG; O-methyltransferase / aklanonic acid methyltransferase [EC:2.1.1.- 2.1.1.288] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 257.0 5.0 0.0 1.0 1.0 Q 0.0 5.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 5.0 0.0 1.0 0.0022641255908199 0.0293002469176482 0.015782186254234 0.0270361213268283 0 0 0 0 K15945 0.0085714285714285 0.0 snoaL2; C-1 hydroxylase path:map01057,path:map01110 Biosynthesis of type II polyketide products,Biosynthesis of secondary metabolites 139.0 3.0 0.0 1.0 1.0 S 3.0 0.0 1.0 1.0 COG5485 Predicted_ester_cyclase 3.0 1.0 0.0 0 0 0 0 K15968 0.0 0.0028490028490028 tcmI; tetracenomycin F2 cyclase [EC:4.2.1.154] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 106.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2C9N8 1.0 0.0 1.0 0 0 0 0 K15969 0.0028571428571428 0.0056980056980056 tcmH; tetracenomycin F1 monooxygenase [EC:1.13.12.21] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 81.0 3.0 0.0 1.0 1.0 S 1.0 2.0 1.0 1.0 COG2329 Heme-degrading_monooxygenase_HmoA_and_related_ABM_domain_proteins HmoA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K15972 0.0 0.0028490028490028 tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 521.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K15973 0.0085714285714285 0.1025641025641025 mhqR; MarR family transcriptional regulator, 2-MHQ and catechol-resistance regulon repressor 93.0 46.0 0.0 1.0 1.0 K 4.0 42.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 46.0 0.0869565217391304 0.9130434782608696 0.0395305144357154 0.10344230266215 0.0714864085489327 0.0639117882264346 0 0 0 0 K15974 0.0 0.0199430199430199 emrR, mprA; MarR family transcriptional regulator, negative regulator of the multidrug operon emrRAB 166.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 7.0 0.0 1.0 3.39951258912819e-07 1.58076561770677e-05 8.07380371799026e-06 1.5467704918154884e-05 0 0 0 0 K15975 0.1142857142857142 0.1566951566951566 K15975; glyoxalase family protein 199.0 144.0 137.0 3.0 0.935064935064935 E 64.0 90.0 3.0 0.954545454545455 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 154.0 0.4155844155844156 0.5844155844155844 0.0250274886136401 0.366995794635675 0.1960116416246575 0.3419683060220349 0 0 0 0 K15976 0.0 0.0113960113960113 K15976; putative NAD(P)H nitroreductase [EC:1.-.-.-] 89.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG0778 Nitroreductase NfnB 4.0 0.0 1.0 0.0700984992585536 0.107091827252618 0.0885951632555858 0.0369933279940643 0 0 0 0 K15977 0.1057142857142857 0.452991452991453 K15977; putative oxidoreductase 29.0 314.0 313.0 2.0 0.996825396825397 S 47.0 288.0 4.0 0.934328358208955 COG2259 Uncharacterized_membrane_protein_YphA,_DoxX/SURF4_family DoxX 335.0 0.1402985074626865 0.8597014925373134 0.0061639753846371 0.0790109434175557 0.0425874594010964 0.0728469680329186 0 0 0 0 K15980 0.0 0.0056980056980056 ACAD9; acyl-CoA dehydrogenase family member 9 [EC:1.3.99.-] 527.0 1.0 0.0 2.0 0.5 C 0.0 2.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 2.0 0.0 1.0 0 0 0 0 K15981 0.0 0.0199430199430199 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29] path:map00984,path:map01120 Steroid degradation,Microbial metabolism in diverse environments 373.0 15.0 14.0 2.0 0.9375 Q 0.0 16.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 16.0 0.0 1.0 0.0006954662875647 0.0019471851819368 0.0013213257347507 0.0012517188943721 0 0 0 0 K15982 0.0 0.017094017094017 kshA; 3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.15.30] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 374.0 7.0 0.0 1.0 1.0 P 0.0 7.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 7.0 0.0 1.0 0.0114989915673581 0.022446010203068 0.016972500885213 0.0109470186357098 0 0 0 0 K15983 0.0 0.037037037037037 kshB; 3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.15.30] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 290.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 15.0 0.0 1.0 0.0399471582949375 0.0664102758980574 0.0531787170964974 0.0264631176031198 0 0 0 0 K15984 0.0171428571428571 0.0883190883190883 rsmJ; 16S rRNA (guanine1516-N2)-methyltransferase [EC:2.1.1.242] 136.0 27.0 23.0 5.0 0.72972972972973 J 6.0 31.0 6.0 0.45945945945946 COG0742 16S_rRNA_G966_N2-methylase_RsmD RsmD 37.0 0.1621621621621621 0.8378378378378378 0.0544751729638014 0.252129281550488 0.1533022272571447 0.1976541085866866 0 0 0 0 K15986 0.1428571428571428 0.2393162393162393 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1] path:map00190 Oxidative phosphorylation 228.0 115.0 105.0 6.0 0.815602836879433 C 54.0 87.0 6.0 0.801418439716312 COG1227 Inorganic_pyrophosphatase/exopolyphosphatase PPX1 141.0 0.3829787234042553 0.6170212765957447 0.26693532889583 0.0973645520736698 0.1821499404847499 0.1695707768221602 0 0 0 0 K15987 0.3942857142857143 0.5641025641025641 hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:7.1.3.2] 512.0 361.0 359.0 3.0 0.991758241758242 C 151.0 213.0 2.0 0.994505494505494 COG3808 Na+_or_H+-translocating_membrane_pyrophosphatase OVP1 364.0 0.4148351648351648 0.5851648351648352 0.623628129042101 0.960817772973778 0.7922229510079395 0.337189643931677 0 1 0 1 K15996 0.0 0.0056980056980056 tylF; macrocin O-methyltransferase [EC:2.1.1.101] path:map00522,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 262.0 1.0 0.0 2.0 0.5 E 0.0 2.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 2.0 0.0 1.0 0 0 0 0 K15997 0.0 0.0028490028490028 eryCII; 3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein path:map00522,path:map01052,path:map01100,path:map01110 Biosynthesis of 12-, 14- and 16-membered macrolides; Including: Tylosin biosynthesis, Mycinamicin biosynthesis, Erythromycin biosynthesis, Oleandomycin biosynthesis, Pikromycin/methymycin biosynthesis, Avermectin biosynthesis,Type I polyketide structures,Metabolic pathways,Biosynthesis of secondary metabolites 353.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K16011 0.1457142857142857 0.4017094017094017 algA, xanB, rfbA, wbpW, pslB; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8] path:map00051,path:map00520,path:map00541,path:map01100,path:map01110,path:map01250,path:map02025 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars,Biofilm formation - Pseudomonas aeruginosa 195.0 176.0 140.0 5.0 0.742616033755274 M 57.0 165.0 3.0 0.523206751054852 COG0836 Mannose-1-phosphate_guanylyltransferase CpsB 222.0 0.2567567567567567 0.7432432432432432 0.448201893247717 0.263220459801039 0.355711176524378 0.184981433446678 0 0 0 0 K16012 0.0 0.2079772079772079 cydC; ATP-binding cassette, subfamily C, bacterial CydC path:map02010 ABC transporters 371.0 38.0 5.0 4.0 0.469135802469136 CO 0.0 81.0 3.0 0.925925925925926 COG4987 ABC-type_transport_system_involved_in_cytochrome_bd_biosynthesis,_fused_ATPase_and_permease_components CydC 81.0 0.0 1.0 0.0219239891569439 0.252380999417379 0.1371524942871614 0.2304570102604351 0 0 0 0 K16013 0.0028571428571428 0.2165242165242165 cydD; ATP-binding cassette, subfamily C, bacterial CydD path:map02010 ABC transporters 401.0 64.0 47.0 3.0 0.727272727272727 V 1.0 87.0 3.0 0.909090909090909 COG4988 ABC-type_transport_system_involved_in_cytochrome_bd_biosynthesis,_ATPase_and_permease_components CydD 88.0 0.0113636363636363 0.9886363636363636 0.0031600147479721 0.0349350363433333 0.0190475255456527 0.0317750215953612 0 0 0 0 K16014 0.0028571428571428 0.0626780626780626 cydCD; ATP-binding cassette, subfamily C, bacterial CydCD path:map02010 ABC transporters 452.0 26.0 24.0 3.0 0.866666666666667 V 2.0 28.0 4.0 0.5 COG4988 ABC-type_transport_system_involved_in_cytochrome_bd_biosynthesis,_ATPase_and_permease_components CydD 30.0 0.0666666666666666 0.9333333333333332 0.0089308122665819 0.0201954499497358 0.0145631311081588 0.0112646376831539 0 0 0 0 K16015 0.0 0.0085470085470085 rifL, asm44; oxidoreductase [EC:1.1.1.-] path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 323.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 3.0 0.0 1.0 0 0 0 0 K16016 0.0085714285714285 0.0085470085470085 rifK, asm24, asm43; 3-amino-5-hydroxybenzoate synthase [EC:4.2.1.144 2.6.1.-] path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 376.0 6.0 0.0 1.0 1.0 E 3.0 3.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 6.0 0.5 0.5 0.0612181016055251 0.087736063652816 0.0744770826291705 0.0265179620472909 0 0 0 0 K16017 0.0057142857142857 0.0056980056980056 rifM, asm45; AHBA synthesis associated protein path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 195.0 4.0 0.0 1.0 1.0 S 2.0 2.0 1.0 1.0 COG0546 Phosphoglycolate_phosphatase,_HAD_superfamily Gph 4.0 0.5 0.5 0.0688530693839256 0.149516234959905 0.1091846521719153 0.0806631655759793 0 0 0 0 K16018 0.0 0.0028490028490028 rifN, asm22; kanosamine 6-kinase [EC:2.7.1.179] path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 363.0 1.0 0.0 1.0 1.0 GK 0.0 1.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 1.0 0.0 1.0 0 0 0 0 K16019 0.0 0.0341880341880341 rifH; 3,4-Dideoxy-4-amino-D-arabino-heptulosonate 7-phosphate synthase path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 439.0 12.0 0.0 1.0 1.0 E 0.0 12.0 1.0 1.0 COG3200 3-deoxy-D-arabino-heptulosonate_7-phosphate_(DAHP)_synthase,_class_II AroG2 12.0 0.0 1.0 1.11366555790103e-07 5.16499224054112e-06 2.6381793981656115e-06 5.0536256847510165e-06 0 0 0 0 K16020 0.0028571428571428 0.0142450142450142 rifG, asm47; 5-deoxy-5-amino-3-dehydroquinate synthase path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 324.0 5.0 4.0 3.0 0.714285714285714 E 1.0 6.0 1.0 1.0 COG0337 3-dehydroquinate_synthetase AroB 7.0 0.1428571428571428 0.8571428571428571 0.0411776929169168 0.127265220564316 0.0842214567406164 0.0860875276473991 0 0 0 0 K16021 0.0 0.0056980056980056 rifJ, asm23; 5-deoxy-5-amino-3-dehydroquinate dehydratase path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 143.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0757 3-dehydroquinate_dehydratase AroQ 2.0 0.0 1.0 0 0 0 0 K16022 0.0028571428571428 0.0028490028490028 rif19; flavoprotein hydroxylase path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 10.0 3.0 0.0 1.0 1.0 CH 2.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K16023 0.0 0.0028490028490028 rif20; acetyltransferase path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 414.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16024 0.0 0.0056980056980056 asm13; methoxymalonate biosynthesis protein path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 276.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 2.0 0.0 1.0 0 0 0 0 K16025 0.0 0.0113960113960113 asm14; methoxymalonate biosynthesis acyl carrier protein path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 78.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 6.0 0.0 1.0 0.0081765771168247 0.0310682743669241 0.0196224257418744 0.0228916972500994 0 0 0 0 K16026 0.0 0.0056980056980056 asm15; methoxymalonate biosynthesis protein path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 358.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 2.0 0.0 1.0 0 0 0 0 K16027 0.0 0.0056980056980056 asm16; methoxymalonate biosynthesis protein path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 236.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG3882 Predicted_enzyme_involved_in_methoxymalonyl-ACP_biosynthesis FkbH 3.0 0.0 1.0 0 0 0 0 K16028 0.0 0.0113960113960113 asm17; O-methyltransferase path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 208.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 4.0 0.0 1.0 0.0346684848446583 0.0807195944467869 0.0576940396457226 0.0460511096021286 0 0 0 0 K16029 0.0 0.0142450142450142 asmA; ansamitocin polyketide synthase A path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 456.0 8.0 0.0 1.0 1.0 IQ 0.0 8.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 8.0 0.0 1.0 5.18979011759685e-13 1.7988334389378999e-12 1.1589062253487925e-12 1.2798544271782153e-12 0 0 0 0 K16031 0.0 0.0028490028490028 asmC; ansamitocin polyketide synthase C path:map01051,path:map01052 Biosynthesis of ansamycins,Type I polyketide structures 1052.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 1.0 0.0 1.0 0 0 0 0 K16033 0.0 0.0085470085470085 asm12; FADH2-dependent halogenase path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 343.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 4.0 0.0 1.0 2.45174122125e-05 0.000814383980079 0.0004194506961457 0.0007898665678665 0 0 0 0 K16034 0.0 0.0028490028490028 asm7; 20-O-methyltransferase path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 322.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 1.0 0.0 1.0 0 0 0 0 K16035 0.0 0.0028490028490028 asm21; 7-O-carbamoyltransferase [EC:2.1.3.-] path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 590.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG2192 Predicted_carbamoyl_transferase,_NodU_family 1.0 0.0 1.0 0 0 0 0 K16037 0.0 0.0085470085470085 asm11; 4,5-epoxidase path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 407.0 4.0 0.0 1.0 1.0 CH 0.0 4.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 4.0 0.0 1.0 6.32466560750213e-05 0.0449411987611252 0.0225022227086001 0.0448779521050501 0 0 0 0 K16038 0.0 0.0028490028490028 asm10; N-methyltransferase [EC:2.1.1.-] path:map01051,path:map01052,path:map01110 Biosynthesis of ansamycins,Type I polyketide structures,Biosynthesis of secondary metabolites 248.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3315 O-Methyltransferase_involved_in_polyketide_biosynthesis YktD 1.0 0.0 1.0 0 0 0 0 K16039 0.0 0.0028490028490028 asm25; N-glycosyltransferase [EC:2.4.1.-] path:map01051,path:map01110 Biosynthesis of ansamycins,Biosynthesis of secondary metabolites 402.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K16043 0.0028571428571428 0.017094017094017 iolX; scyllo-inositol 2-dehydrogenase (NAD+) [EC:1.1.1.370] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 253.0 9.0 0.0 1.0 1.0 S 2.0 7.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 9.0 0.2222222222222222 0.7777777777777778 0.020350969897083 0.0414022668134033 0.0308766183552431 0.0210512969163203 0 0 0 0 K16044 0.0085714285714285 0.1054131054131054 iolW; scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.371] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 198.0 56.0 55.0 2.0 0.982456140350877 S 3.0 54.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 57.0 0.0526315789473684 0.9473684210526316 0.0064942742745803 0.0110742504483334 0.0087842623614568 0.0045799761737531 0 0 0 0 K16045 0.0 0.0113960113960113 hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] path:map00984,path:map01120 Steroid degradation,Microbial metabolism in diverse environments 312.0 3.0 2.0 2.0 0.75 M 0.0 4.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 4.0 0.0 1.0 0.0201379362561927 0.0409116250353036 0.0305247806457481 0.0207736887791109 0 0 0 0 K16046 0.0 0.0028490028490028 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28] path:map00984,path:map01120 Steroid degradation,Microbial metabolism in diverse environments 403.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K16047 0.0 0.0341880341880341 hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 356.0 16.0 0.0 1.0 1.0 I 0.0 16.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 16.0 0.0 1.0 0.0045677400516673 0.0222253743445776 0.0133965571981224 0.0176576342929103 0 0 0 0 K16048 0.0057142857142857 0.0541310541310541 hsaB; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-] path:map00984,path:map01100 Steroid degradation,Metabolic pathways 136.0 12.0 2.0 3.0 0.521739130434783 K 3.0 20.0 2.0 0.956521739130435 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 23.0 0.1304347826086956 0.8695652173913043 0.0416434252398588 0.0432690009686257 0.0424562131042422 0.0016255757287669 0 0 0 0 K16049 0.0 0.0256410256410256 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25] path:map00984,path:map01100,path:map01120,path:map01220 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 286.0 9.0 0.0 1.0 1.0 E 0.0 9.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 9.0 0.0 1.0 0.0282565853636628 0.0656251240760412 0.0469408547198519 0.0373685387123784 0 0 0 0 K16050 0.0 0.0512820512820512 hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17] path:map00984,path:map01100,path:map01120,path:map01220 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 249.0 17.0 15.0 2.0 0.894736842105263 I 0.0 19.0 2.0 0.894736842105263 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 19.0 0.0 1.0 0.001856461121629 0.0074720681414364 0.0046642646315327 0.0056156070198074 0 0 0 0 K16051 0.0 0.017094017094017 tesI; 3-oxo-5alpha-steroid 4-dehydrogenase [EC:1.3.99.5] path:map00984,path:map01120 Steroid degradation,Microbial metabolism in diverse environments 482.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 6.0 0.0 1.0 0.0594232418388918 0.149217809069673 0.1043205254542824 0.0897945672307811 0 0 0 0 K16052 0.3257142857142857 0.2678062678062678 ynaI, mscMJ; MscS family membrane protein 78.0 274.0 0.0 1.0 1.0 M 151.0 123.0 4.0 0.836956521739131 COG0668 Small-conductance_mechanosensitive_channel MscS 274.0 0.551094890510949 0.4489051094890511 0.860008397164436 0.482164302131896 0.671086349648166 0.37784409503254 1 1 1 1 K16053 0.0 0.1452991452991453 ybdG, mscM; miniconductance mechanosensitive channel 314.0 56.0 0.0 1.0 1.0 M 0.0 56.0 1.0 1.0 COG0668 Small-conductance_mechanosensitive_channel MscS 56.0 0.0 1.0 0.0198142603722049 0.192227408406121 0.1060208343891629 0.172413148033916 0 0 0 0 K16054 0.0 0.0028490028490028 DEP1; methylthioribulose 1-phosphate dehydratase / enolase-phosphatase E1 [EC:4.2.1.109 3.1.3.77] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 247.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 1.0 0.0 1.0 0 0 0 0 K16055 0.0685714285714285 0.2051282051282051 TPS; trehalose 6-phosphate synthase/phosphatase [EC:2.4.1.15 3.1.3.12] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 345.0 102.0 0.0 1.0 1.0 G 26.0 75.0 2.0 0.96078431372549 COG0380 Trehalose-6-phosphate_synthase,_GT20_family OtsA 101.0 0.2574257425742574 0.7425742574257426 0.122822594555371 0.201218062557369 0.16202032855637 0.0783954680019979 0 0 0 0 K16066 0.0 0.0826210826210826 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] path:map00240,path:map00260,path:map01100 Pyrimidine metabolism,Glycine, serine and threonine metabolism,Metabolic pathways 232.0 26.0 24.0 3.0 0.896551724137931 S 0.0 29.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 29.0 0.0 1.0 0.0180842857490857 0.0473200140346095 0.0327021498918476 0.0292357282855238 0 0 0 0 K16074 0.0028571428571428 0.094017094017094 zntB; zinc transporter 230.0 37.0 0.0 1.0 1.0 P 1.0 36.0 1.0 1.0 COG0598 Mg2+_and_Co2+_transporter_CorA CorA 37.0 0.027027027027027 0.972972972972973 0.0265401806093168 0.0446693600220173 0.035604770315667 0.0181291794127005 0 0 0 0 K16076 0.0 0.0056980056980056 nmpC, ompD; outer membrane porin protein LC 80.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 4.0 0.0 1.0 1.95340450499358e-12 3.35340968537218e-12 2.65340709518288e-12 1.4000051803785998e-12 0 0 0 0 K16077 0.0 0.0085470085470085 scrY; sucrose porin 378.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 1.0 1.0 COG4580 Maltoporin_(phage_lambda_and_maltose_receptor) LamB 3.0 0.0 1.0 0 0 0 0 K16078 0.0 0.0028490028490028 ail; attachment invasion locus protein 179.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28V67 1.0 0.0 1.0 0 0 0 0 K16079 0.0 0.0683760683760683 omp31; outer membrane immunogenic protein 64.0 69.0 0.0 1.0 1.0 M 0.0 69.0 2.0 0.971014492753623 COG3637 Opacity_protein_LomR_and_related_surface_antigens LomR 69.0 0.0 1.0 0.0012376895855597 0.0020014871431539 0.0016195883643567 0.0007637975575941 0 0 0 0 K16080 0.0 0.0085470085470085 mnoP; high affinity Mn2+ porin 201.0 4.0 0.0 1.0 1.0 M 0.0 4.0 2.0 0.75 COG3659 Carbohydrate-selective_porin_OprB OprB 4.0 0.0 1.0 6.1221719887375e-12 0.100254858621336 0.050127429313729 0.1002548586152138 0 0 0 0 K16081 0.0 0.0142450142450142 algE; alginate production protein 318.0 7.0 0.0 1.0 1.0 S 0.0 7.0 2.0 0.571428571428571 2A2RR 7.0 0.0 1.0 0.0194683793757202 0.0242532250853642 0.0218608022305422 0.004784845709644 0 0 0 0 K16086 0.0028571428571428 0.0 E3.1.7.10; (13E)-labda-7,13-dien-15-ol synthase [EC:3.1.7.10] path:map00904,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Biosynthesis of secondary metabolites 489.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2CKJS 1.0 1.0 0.0 0 0 0 0 K16087 0.0057142857142857 0.1908831908831909 TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein 134.0 84.0 78.0 6.0 0.857142857142857 P 2.0 96.0 7.0 0.826530612244898 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 98.0 0.0204081632653061 0.979591836734694 0.057194515348001 0.0610354693373519 0.0591149923426764 0.0038409539893509 0 0 0 0 K16088 0.0 0.037037037037037 TC.FEV.OM1, fhuE, fpvA, fptA; outer-membrane receptor for ferric coprogen and ferric-rhodotorulic acid 530.0 19.0 17.0 2.0 0.904761904761905 P 0.0 21.0 1.0 1.0 COG4773 Outer_membrane_receptor_for_ferric_coprogen_and_ferric-rhodotorulic_acid FhuE 21.0 0.0 1.0 0.0174331832202848 0.0374821936531142 0.0274576884366994 0.0200490104328294 0 0 0 0 K16089 0.0028571428571428 0.2222222222222222 TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins 86.0 115.0 97.0 4.0 0.76158940397351 P 1.0 150.0 4.0 0.860927152317881 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 151.0 0.0066225165562913 0.9933774834437086 0.0076350746472061 0.0815599832524401 0.0445975289498231 0.073924908605234 0 0 0 0 K16090 0.0 0.0712250712250712 fiu; catecholate siderophore receptor 467.0 33.0 0.0 1.0 1.0 P 0.0 33.0 1.0 1.0 COG4774 Outer_membrane_receptor_for_monomeric_catechols Fiu 33.0 0.0 1.0 0.0320911387387762 0.0359879150911511 0.0340395269149636 0.0038967763523749 0 0 0 0 K16091 0.0 0.1196581196581196 fecA; Fe(3+) dicitrate transport protein 288.0 46.0 43.0 3.0 0.92 P 0.0 54.0 6.0 0.833333333333333 COG4772 Outer_membrane_receptor_for_Fe3+-dicitrate FecA 54.0 0.0 1.0 0.0080824083674919 0.0685478990911921 0.038315153729342 0.0604654907237002 0 0 0 0 K16092 0.0 0.282051282051282 btuB; vitamin B12 transporter 133.0 97.0 66.0 3.0 0.746153846153846 H 0.0 130.0 4.0 0.846153846153846 COG4206 Outer_membrane_cobalamin_receptor_protein_BtuB BtuB 130.0 0.0 1.0 0.0370497060235756 0.323442250295757 0.1802459781596663 0.2863925442721814 0 0 0 0 K16119 0.0 0.0028490028490028 1897.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16122 0.0 0.0028490028490028 tycA; tyrocidine synthetase I path:map01054 Nonribosomal peptide structures 213.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16124 0.0 0.0028490028490028 tycC; tyrocidine synthetase III path:map01054 Nonribosomal peptide structures 499.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16126 0.0 0.0028490028490028 syrB1; L-threonine---[L-threonyl-carrier protein] ligase [EC:6.2.1.70] path:map01054 Nonribosomal peptide structures 1199.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16127 0.0 0.0028490028490028 mcyG; microcystin synthetase protein McyG path:map01054 Nonribosomal peptide structures 2894.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 1.0 0.0 1.0 0 0 0 0 K16128 0.0 0.0056980056980056 mcyD; microcystin synthetase protein McyD path:map01054 Nonribosomal peptide structures 1421.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 2.0 0.75 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 4.0 0.0 1.0 2.34392994649697e-13 6.77512118677031e-13 4.55952556663364e-13 4.4311912402733403e-13 0 0 0 0 K16129 0.0 0.017094017094017 mcyE; microcystin synthetase protein McyE path:map01054 Nonribosomal peptide structures 151.0 5.0 2.0 2.0 0.625 Q 0.0 8.0 4.0 0.375 COG0500 SAM-dependent_methyltransferase SmtA 8.0 0.0 1.0 0.0044657220129142 0.0142297987312225 0.0093477603720683 0.0097640767183082 0 0 0 0 K16130 0.0 0.0113960113960113 mcyA; microcystin synthetase protein McyA path:map01054 Nonribosomal peptide structures 91.0 4.0 0.0 1.0 1.0 J 0.0 4.0 2.0 0.75 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 4.0 0.0 1.0 0.384973822661153 0.427970726927259 0.406472274794206 0.042996904266106 0 0 0 0 K16133 0.0 0.0085470085470085 mcyI; microcystin synthetase protein McyI path:map01054 Nonribosomal peptide structures 315.0 3.0 0.0 1.0 1.0 EH 0.0 3.0 1.0 1.0 COG0111 Phosphoglycerate_dehydrogenase_or_related_dehydrogenase SerA 3.0 0.0 1.0 0 0 0 0 K16135 0.0 0.0142450142450142 dmlR; LysR family transcriptional regulator, transcriptional activator for dmlA 295.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 8.0 0.0 1.0 0.007160743450541 0.0140199789969231 0.010590361223732 0.0068592355463821 0 0 0 0 K16136 0.0 0.0085470085470085 malI; LacI family transcriptional regulator, maltose regulon regulatory protein 337.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 3.0 0.0 1.0 0 0 0 0 K16137 0.0542857142857142 0.2706552706552707 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon 58.0 179.0 0.0 1.0 1.0 K 24.0 155.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 179.0 0.1340782122905028 0.8659217877094972 0.0113193426869372 0.0594207887277687 0.0353700657073529 0.0481014460408315 0 0 0 0 K16138 0.0 0.0085470085470085 uidR; TetR/AcrR family transcriptional regulator, repressor for uid operon 189.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 3.0 0.0 1.0 0 0 0 0 K16139 0.0028571428571428 0.017094017094017 uidB, gusB; glucuronide carrier protein 427.0 7.0 5.0 3.0 0.7 G 1.0 9.0 2.0 0.8 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 10.0 0.1 0.9 0.0257115537769131 0.0470251037510191 0.0363683287639661 0.021313549974106 0 0 0 0 K16140 0.0 0.0028490028490028 uidC, gusC; putative glucuronide porin 421.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 2DBSC 1.0 0.0 1.0 0 0 0 0 K16146 0.0371428571428571 0.0541310541310541 pep2; maltokinase [EC:2.7.1.175] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 208.0 37.0 0.0 1.0 1.0 G 13.0 24.0 2.0 0.972972972972973 COG3281 Predicted_trehalose_synthase Ble 37.0 0.3513513513513513 0.6486486486486487 0.069149492147419 0.443099231153478 0.2561243616504485 0.373949739006059 0 0 0 0 K16147 0.0114285714285714 0.188034188034188 glgE; starch synthase (maltosyl-transferring) [EC:2.4.99.16] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 446.0 64.0 61.0 6.0 0.888888888888889 G 4.0 68.0 3.0 0.902777777777778 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 72.0 0.0555555555555555 0.9444444444444444 0.0093465483212373 0.0673655443206296 0.0383560463209334 0.0580189959993923 0 0 0 0 K16148 0.0171428571428571 0.0655270655270655 glgM; alpha-maltose-1-phosphate synthase [EC:2.4.1.342] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 340.0 18.0 7.0 2.0 0.620689655172414 G 6.0 23.0 2.0 0.620689655172414 COG0297 Glycogen_synthase GlgA 29.0 0.2068965517241379 0.7931034482758621 0.0103519556857505 0.0212398213920277 0.0157958885388891 0.0108878657062772 0 0 0 0 K16149 0.0828571428571428 0.1937321937321937 K16149; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 220.0 88.0 79.0 4.0 0.822429906542056 G 31.0 76.0 4.0 0.719626168224299 COG1543 Predicted_glycosyl_hydrolase,_contains_GH57_and_DUF1957_domains 107.0 0.2897196261682243 0.7102803738317757 0.743297798144437 0.261802019171723 0.50254990865808 0.4814957789727139 0 1 0 1 K16150 0.1314285714285714 0.0683760683760683 K16150; glycogen synthase [EC:2.4.1.11] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 140.0 55.0 39.0 4.0 0.670731707317073 G 56.0 26.0 2.0 0.817073170731707 COG0297 Glycogen_synthase GlgA 82.0 0.6829268292682927 0.3170731707317073 0.976204159115871 0.994682403709656 0.9854432814127636 0.0184782445937849 1 1 1 1 K16153 0.02 0.0569800569800569 K16153; glycogen phosphorylase/synthase [EC:2.4.1.1 2.4.1.11] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 162.0 29.0 26.0 2.0 0.90625 G 7.0 25.0 2.0 0.90625 COG0058 Glucan_phosphorylase GlgP 32.0 0.21875 0.78125 0.0128077256524219 0.0942253613480433 0.0535165435002326 0.0814176356956214 0 0 0 0 K16157 0.0 0.0256410256410256 mmoX; methane monooxygenase component A alpha chain [EC:1.14.13.25] path:map00680,path:map01100,path:map01120,path:map01200,path:map01220 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Degradation of aromatic compounds 73.0 9.0 0.0 1.0 1.0 T 0.0 9.0 1.0 1.0 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 9.0 0.0 1.0 0.0040641765630332 0.0201667126475858 0.0121154446053095 0.0161025360845526 0 0 0 0 K16161 0.0028571428571428 0.0284900284900284 mmoC; methane monooxygenase component C [EC:1.14.13.25] path:map00680,path:map01100,path:map01120,path:map01200,path:map01220 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism,Degradation of aromatic compounds 296.0 14.0 0.0 1.0 1.0 C 2.0 12.0 3.0 0.642857142857143 COG0543 NAD(P)H-flavin_reductase Mcr1 14.0 0.1428571428571428 0.8571428571428571 0.0480303961536409 0.107887414129705 0.0779589051416729 0.059857017976064 0 0 0 0 K16163 0.0 0.0512820512820512 K16163; maleylpyruvate isomerase [EC:5.2.1.4] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 160.0 16.0 8.0 2.0 0.666666666666667 S 0.0 24.0 1.0 1.0 2C7TJ 24.0 0.0 1.0 0.0077152496499692 0.0308879506134959 0.0193016001317325 0.0231727009635267 0 0 0 0 K16164 0.0 0.0313390313390313 K16164; acylpyruvate hydrolase [EC:3.7.1.5] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 260.0 12.0 0.0 1.0 1.0 Q 0.0 12.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 12.0 0.0 1.0 0.0039504386125736 0.0224300647035137 0.0131902516580436 0.0184796260909401 0 0 0 0 K16165 0.0085714285714285 0.094017094017094 nagK; fumarylpyruvate hydrolase [EC:3.7.1.20] path:map00350,path:map01100,path:map01120 Tyrosine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 210.0 40.0 0.0 1.0 1.0 Q 3.0 37.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 40.0 0.075 0.925 0.0040351320041397 0.0132265311277271 0.0086308315659334 0.0091913991235874 0 0 0 0 K16167 0.0 0.0911680911680911 bpsA, srsA, pks11, pks10; alkylresorcinol/alkylpyrone synthase 292.0 33.0 0.0 1.0 1.0 Q 0.0 33.0 1.0 1.0 COG3424 Predicted_naringenin-chalcone_synthase BH0617 33.0 0.0 1.0 0.0013397232744691 0.342256816275075 0.171798269774772 0.3409170930006059 0 0 0 0 K16168 0.0 0.0512820512820512 bpsB, srsB; methyltransferase 152.0 18.0 0.0 1.0 1.0 S 0.0 18.0 1.0 1.0 COG1755 Uncharacterized_conserved_protein_YpbQ,_isoprenylcysteine_carboxyl_methyltransferase_(ICMT)_family YpbQ 18.0 0.0 1.0 0.0117681016376634 0.857463974848666 0.4346160382431647 0.8456958732110026 0 0 0 0 K16169 0.0 0.0284900284900284 pbuX; xanthine permease 396.0 13.0 0.0 1.0 1.0 F 0.0 13.0 1.0 1.0 COG2233 Xanthine/uracil_permease UraA 13.0 0.0 1.0 0.009820239696225 0.0771369256139186 0.0434785826550718 0.0673166859176936 0 0 0 0 K16171 0.0171428571428571 0.1054131054131054 faaH; fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2] path:map00350,path:map00643,path:map01100,path:map01120 Tyrosine metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 219.0 45.0 0.0 1.0 1.0 Q 7.0 38.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 45.0 0.1555555555555555 0.8444444444444444 0.0011544357737845 0.0667498850981453 0.0339521604359649 0.0655954493243608 0 0 0 0 K16173 0.0114285714285714 0.0512820512820512 acd; glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 381.0 22.0 19.0 2.0 0.88 I 5.0 20.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 25.0 0.2 0.8 0.079473600819978 0.630047705598434 0.354760653209206 0.550574104778456 0 0 0 0 K16176 0.0 0.0 mtmB; methylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.248] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 93.0 76.0 2.0 0.845454545454545 H 0.0 0.0 1.0 1.0 arCOG05143 0.0 0 0 0 0 K16177 0.0285714285714285 0.0 mtmC; monomethylamine corrinoid protein path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 214.0 20.0 0.0 1.0 1.0 S 20.0 0.0 1.0 1.0 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 20.0 1.0 0.0 2.57834669623881e-10 4.72304869202878e-13 1.2915348724654195e-10 2.573623647546781e-10 0 0 0 0 K16178 0.0571428571428571 0.0028490028490028 mtbB; dimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.249] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 87.0 73.0 0.0 1.0 1.0 H 71.0 2.0 1.0 1.0 arCOG06710 73.0 0.9726027397260274 0.0273972602739726 0.0298754141153756 0.559521971823111 0.2946986929692433 0.5296465577077354 0 0 0 0 K16179 0.0971428571428571 0.0 mtbC; dimethylamine corrinoid protein path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 205.0 57.0 0.0 1.0 1.0 S 57.0 0.0 1.0 1.0 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 57.0 1.0 0.0 0.0735836017986199 0.0315490918841446 0.0525663468413822 0.0420345099144753 0 0 0 0 K16180 0.08 0.0769230769230769 pylB; methylornithine synthase [EC:5.4.99.58] path:map00300,path:map01100,path:map01120 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments 231.0 40.0 23.0 2.0 0.701754385964912 H 30.0 27.0 1.0 1.0 COG0502 Biotin_synthase_or_related_enzyme BioB 57.0 0.5263157894736842 0.4736842105263157 0.0254758027885143 0.113333742279906 0.0694047725342101 0.0878579394913917 0 0 0 0 K16181 0.0742857142857142 0.017094017094017 pylC; 3-methylornithine--L-lysine ligase [EC:6.3.2.59] path:map00300,path:map01100,path:map01120 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments 252.0 19.0 9.0 5.0 0.542857142857143 E 28.0 7.0 5.0 0.628571428571429 COG0458 Carbamoylphosphate_synthase_large_subunit CarB 35.0 0.8 0.2 0.0039910079301336 0.0134907902637388 0.0087408990969362 0.0094997823336052 0 0 0 0 K16182 0.0628571428571428 0.0199430199430199 pylD; 3-methylornithyl-N6-L-lysine dehydrogenase [EC:1.4.1.-] path:map00300,path:map01100,path:map01120 Lysine biosynthesis,Metabolic pathways,Microbial metabolism in diverse environments 215.0 9.0 5.0 2.0 0.692307692307692 E 24.0 7.0 4.0 0.580645161290323 arCOG05004 31.0 0.7741935483870968 0.2258064516129032 0.472718259203475 0.657652459902902 0.5651853595531885 0.184934200699427 0 0 0 0 K16183 0.06 0.0 ramA; [Co(II) methylated amine-specific corrinoid protein] reductase [EC:1.16.99.1] 526.0 26.0 0.0 1.0 1.0 C 26.0 0.0 2.0 0.961538461538462 COG3894 Uncharacterized_2Fe-2S_and_4Fe-4S_clusters-containing_protein,_contains_DUF4445_domain 26.0 1.0 0.0 0.0078097577561193 0.0097092287655668 0.008759493260843 0.0018994710094474 0 0 0 0 K16185 0.0285714285714285 0.0 RRAGA_B; Ras-related GTP-binding protein A/B path:map04140,path:map04150,path:map05131 Autophagy - animal,mTOR signaling pathway,Shigellosis 124.0 28.0 17.0 2.0 0.717948717948718 U 39.0 0.0 1.0 1.0 KOG3886 39.0 1.0 0.0 0.541509098141819 0.850071071026656 0.6957900845842375 0.308561972884837 0 0 0 1 K16186 0.0085714285714285 0.0 RRAGC_D; Ras-related GTP-binding protein C/D path:map04140,path:map04150,path:map05131 Autophagy - animal,mTOR signaling pathway,Shigellosis 281.0 5.0 0.0 1.0 1.0 U 5.0 0.0 1.0 1.0 KOG3887 5.0 1.0 0.0 0.727255469814046 0.941703189480927 0.8344793296474865 0.214447719666881 0 0 0 1 K16188 0.0 0.0341880341880341 ytpB; tetraprenyl-beta-curcumene synthase [EC:4.2.3.130] 312.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 2C5HJ 16.0 0.0 1.0 0.0029873249937917 0.0545214101172055 0.0287543675554986 0.0515340851234138 0 0 0 0 K16190 0.0085714285714285 0.017094017094017 GLCAK; glucuronokinase [EC:2.7.1.43] path:map00040,path:map00053,path:map00520,path:map01100,path:map01250 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 266.0 7.0 6.0 3.0 0.777777777777778 I 3.0 6.0 2.0 0.777777777777778 COG1577 Mevalonate_kinase ERG12 9.0 0.3333333333333333 0.6666666666666666 0.0226808540884876 0.100047965513871 0.0613644098011793 0.0773671114253834 0 0 0 0 K16191 0.0 0.017094017094017 K16191, arfA; peptidoglycan-binding protein ArfA 235.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 6.0 0.0 1.0 0.0497199316606029 0.0883067853318697 0.0690133584962363 0.0385868536712667 0 0 0 0 K16193 0.0 0.074074074074074 arfC; uncharacterized membrane protein ArfC 88.0 39.0 0.0 1.0 1.0 J 0.0 40.0 3.0 0.5 COG0088 Ribosomal_protein_L4 RplD 40.0 0.0 1.0 0.747475107142355 0.465917078718064 0.6066960929302094 0.281558028424291 0 0 0 1 K16199 0.0 0.0142450142450142 dppE; dipeptide transport system substrate-binding protein path:map02010 ABC transporters 536.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG4166 ABC-type_oligopeptide_transport_system,_periplasmic_component OppA 5.0 0.0 1.0 0.0192865114711299 0.0626859046058291 0.0409862080384795 0.0433993931346991 0 0 0 0 K16200 0.0 0.0142450142450142 dppB1; dipeptide transport system permease protein path:map02010 ABC transporters 308.0 3.0 1.0 2.0 0.6 P 0.0 5.0 1.0 1.0 COG0601 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppB 5.0 0.0 1.0 0.0118951779670343 0.0518729727383447 0.0318840753526895 0.0399777947713104 0 0 0 0 K16201 0.0 0.0199430199430199 dppC; dipeptide transport system permease protein path:map02010 ABC transporters 256.0 4.0 1.0 2.0 0.571428571428571 EP 0.0 7.0 1.0 1.0 COG1173 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_permease_component DppC 7.0 0.0 1.0 0.0124339725498937 0.0533460537158352 0.0328900131328644 0.0409120811659415 0 0 0 0 K16202 0.0 0.0113960113960113 dppD; dipeptide transport system ATP-binding protein path:map02010 ABC transporters 317.0 6.0 4.0 2.0 0.75 EP 0.0 8.0 1.0 1.0 COG0444 ABC-type_dipeptide/oligopeptide/nickel_transport_system,_ATPase_component DppD 8.0 0.0 1.0 0.0042601666969009 0.0116046524389992 0.00793240956795 0.0073444857420983 0 0 0 0 K16203 0.0857142857142857 0.1566951566951566 dppA1; D-amino peptidase [EC:3.4.11.-] 153.0 100.0 91.0 2.0 0.91743119266055 E 40.0 69.0 2.0 0.91743119266055 COG2362 D-aminopeptidase DppA 109.0 0.3669724770642202 0.6330275229357798 0.820038995110195 0.975461252996034 0.8977501240531145 0.155422257885839 1 1 1 1 K16209 0.0 0.0313390313390313 lacS, galP, rafP; lactose/raffinose/galactose permease 238.0 14.0 0.0 1.0 1.0 G 0.0 14.0 2.0 0.928571428571429 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 14.0 0.0 1.0 0.0135606604892052 0.0267548900768432 0.0201577752830241 0.0131942295876379 0 0 0 0 K16210 0.0171428571428571 0.0626780626780626 togT, rhiT; oligogalacturonide transporter 139.0 25.0 4.0 2.0 0.543478260869565 K 9.0 37.0 3.0 0.543478260869565 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 46.0 0.1956521739130435 0.8043478260869565 0.530406081676841 0.0067768490182775 0.2685914653475592 0.5236292326585635 0 1 0 1 K16211 0.0057142857142857 0.094017094017094 malY, malT; maltose/moltooligosaccharide transporter 342.0 39.0 37.0 3.0 0.906976744186046 G 2.0 41.0 4.0 0.883720930232558 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 43.0 0.0465116279069767 0.9534883720930232 0.0232881373335248 0.0620480491996119 0.0426680932665683 0.0387599118660871 0 0 0 0 K16212 0.0 0.037037037037037 mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] 378.0 12.0 11.0 2.0 0.923076923076923 G 0.0 13.0 1.0 1.0 COG2152 Predicted_glycosyl_hydrolase,_GH43/DUF377_family 13.0 0.0 1.0 0.0970115462569559 0.158267953534479 0.1276397498957174 0.0612564072775231 0 0 0 0 K16213 0.04 0.0712250712250712 cbe, mbe; cellobiose epimerase [EC:5.1.3.11] 221.0 47.0 0.0 1.0 1.0 G 16.0 31.0 1.0 1.0 COG2942 Mannose_or_cellobiose_epimerase,_N-acyl-D-glucosamine_2-epimerase_family YihS 47.0 0.3404255319148936 0.6595744680851063 0.712604214329815 0.230326204976143 0.471465209652979 0.482278009353672 0 1 0 1 K16214 0.0 0.0056980056980056 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176] 242.0 0.0 2.0 1.0 1.0 COG4185 Predicted_ABC-type_ATPase_or_kinase 2.0 0.0 1.0 0 0 0 0 K16215 0.0 0.0028490028490028 mrsA; 2-ketoarginine methyltransferase [EC:2.1.1.243] 236.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 1.0 0.0 1.0 0 0 0 0 K16216 0.0114285714285714 0.0256410256410256 yueD; benzil reductase ((S)-benzoin forming) [EC:1.1.1.320] 215.0 11.0 9.0 2.0 0.846153846153846 IQ 4.0 9.0 2.0 0.846153846153846 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 13.0 0.3076923076923077 0.6923076923076923 0.0065996537774391 0.0195084774183432 0.0130540655978911 0.0129088236409041 0 0 0 0 K16217 0.0057142857142857 0.0113960113960113 gppmt; geranyl diphosphate 2-C-methyltransferase [EC:2.1.1.255] 190.0 3.0 0.0 2.0 0.5 M 2.0 4.0 2.0 0.5 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 6.0 0.3333333333333333 0.6666666666666666 0.0908394325188754 0.166721736496104 0.1287805845074897 0.0758823039772286 0 0 0 0 K16218 0.0 0.0085470085470085 mibs; 2-methylisoborneol synthase [EC:4.2.3.118] 185.0 3.0 0.0 1.0 1.0 NU 0.0 3.0 1.0 1.0 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 3.0 0.0 1.0 0 0 0 0 K16227 0.0 0.0085470085470085 gplH; glycopeptidolipid biosynthesis protein 71.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3251 MbtH_family_protein,_regulates_adenylation_domains_of_NRPSs MbtH 3.0 0.0 1.0 0 0 0 0 K16229 0.0 0.0028490028490028 mps2; glycopeptidolipid biosynthesis protein 138.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K16233 0.0 0.0028490028490028 pks18; alpha-pyrone synthase 371.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3424 Predicted_naringenin-chalcone_synthase BH0617 1.0 0.0 1.0 0 0 0 0 K16234 0.0 0.0199430199430199 hutT; histidine transporter 454.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 8.0 0.0 1.0 0.0132723401504392 0.0342770021604767 0.0237746711554579 0.0210046620100375 0 0 0 0 K16235 0.0 0.017094017094017 mmuP; S-methylmethionine transporter 439.0 7.0 0.0 1.0 1.0 E 0.0 7.0 2.0 0.857142857142857 COG0833 Amino_acid_permease LysP 7.0 0.0 1.0 0.070276513231007 0.183223520240957 0.126750016735982 0.11294700700995 0 0 0 0 K16236 0.0 0.0056980056980056 hutM; histidine permease 440.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG0833 Amino_acid_permease LysP 2.0 0.0 1.0 0 0 0 0 K16237 0.0 0.0227920227920227 aroP; aromatic amino acid permease 433.0 11.0 0.0 1.0 1.0 E 0.0 11.0 1.0 1.0 COG1113 L-asparagine_transporter_or_related_permease AnsP 11.0 0.0 1.0 0.012917099526886 0.0364795247567318 0.0246983121418089 0.0235624252298458 0 0 0 0 K16238 0.0457142857142857 0.0968660968660968 eat, eutP; ethanolamine permease 359.0 59.0 0.0 1.0 1.0 E 17.0 42.0 3.0 0.610169491525424 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 59.0 0.288135593220339 0.711864406779661 0.0513000556941985 0.18025364658913 0.1157768511416642 0.1289535908949315 0 0 0 0 K16239 0.02 0.0341880341880341 bsdC; 4-hydroxybenzoate decarboxylase subunit C [EC:4.1.1.61] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 449.0 20.0 0.0 1.0 1.0 H 7.0 13.0 1.0 1.0 COG0043 3-polyprenyl-4-hydroxybenzoate_decarboxylase UbiD 20.0 0.35 0.65 0.398052348486804 0.71901813795209 0.558535243219447 0.320965789465286 0 0 0 0 K16240 0.0 0.0028490028490028 SPA1; protein suppressor of PHYA-105 1 path:map04712 Circadian rhythm - plant 126.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG5641 1.0 0.0 1.0 0 0 0 0 K16242 0.0 0.0484330484330484 dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243] path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 73.0 9.0 1.0 2.0 0.529411764705882 T 0.0 17.0 1.0 1.0 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 17.0 0.0 1.0 0.0078124227351167 0.027002912376529 0.0174076675558228 0.0191904896414123 0 0 0 0 K16243 0.0 0.0313390313390313 dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243] path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 318.0 10.0 9.0 3.0 0.833333333333333 S 0.0 12.0 1.0 1.0 2DB9W 12.0 0.0 1.0 0.037752450866328 0.079497642993353 0.0586250469298405 0.041745192127025 0 0 0 0 K16244 0.0 0.0199430199430199 dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243] path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 86.0 6.0 3.0 2.0 0.666666666666667 Q 0.0 9.0 1.0 1.0 2CJVU 9.0 0.0 1.0 0.0016891150250943 0.0105778376963903 0.0061334763607422 0.008888722671296 0 0 0 0 K16245 0.0 0.0199430199430199 dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243] path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 105.0 7.0 6.0 2.0 0.875 S 0.0 8.0 1.0 1.0 2DGRK 8.0 0.0 1.0 0.024175433427914 0.0808335792074392 0.0525045063176766 0.0566581457795251 0 0 0 0 K16246 0.0114285714285714 0.0341880341880341 dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243] path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 197.0 16.0 0.0 1.0 1.0 C 4.0 12.0 4.0 0.5 COG2871 Na+-transporting_NADH:ubiquinone_oxidoreductase,_subunit_NqrF NqrF 16.0 0.25 0.75 0.124795383487288 0.275413937684117 0.2001046605857024 0.1506185541968289 0 0 0 0 K16247 0.0 0.0199430199430199 gutR; LuxR family transcriptional regulator, glucitol operon activator 320.0 11.0 10.0 2.0 0.916666666666667 K 0.0 11.0 4.0 0.666666666666667 COG3903 Predicted_ATPase 11.0 0.0 1.0 0.0101020202026875 0.0232563192422912 0.0166791697224893 0.0131542990396036 0 0 0 0 K16248 0.0028571428571428 0.0142450142450142 gutA, gutP; probable glucitol transport protein GutA 436.0 12.0 0.0 1.0 1.0 G 2.0 10.0 1.0 1.0 COG2211 Na+/melibiose_symporter_or_related_transporter MelB 12.0 0.1666666666666666 0.8333333333333334 3.4038933579679698e-12 0.0212419305828528 0.0106209652931283 0.0212419305794489 0 0 0 0 K16249 0.0 0.0085470085470085 dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0 path:map00361,path:map00362,path:map00623,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 76.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2C44J 3.0 0.0 1.0 0 0 0 0 K16254 0.0 0.0113960113960113 mxaJ; mxaJ protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 287.0 5.0 0.0 1.0 1.0 ET 0.0 5.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 5.0 0.0 1.0 5.054831423691e-06 0.0160474671533782 0.0080262609924009 0.0160424123219545 0 0 0 0 K16255 0.0 0.0085470085470085 mxaG; cytochrome c-L path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 182.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 3.0 0.0 1.0 0 0 0 0 K16256 0.0 0.0113960113960113 mxaA; mxaA protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 274.0 0.0 4.0 2.0 0.75 29WHQ 4.0 0.0 1.0 0 0 0 0 K16257 0.0 0.0142450142450142 mxaC; mxaC protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 317.0 4.0 3.0 2.0 0.8 S 0.0 5.0 1.0 1.0 COG2304 Secreted_protein_containing_bacterial_Ig-like_domain_and_vWFA_domain YfbK 5.0 0.0 1.0 0.0609798490574264 0.146425327176806 0.1037025881171162 0.0854454781193796 0 0 0 0 K16258 0.0 0.0113960113960113 mxaK; mxaK protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 176.0 0.0 4.0 2.0 0.75 2B8R8 4.0 0.0 1.0 0 0 0 0 K16259 0.0 0.0199430199430199 mxaL; mxaL protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 282.0 4.0 1.0 2.0 0.571428571428571 S 0.0 7.0 1.0 1.0 COG2304 Secreted_protein_containing_bacterial_Ig-like_domain_and_vWFA_domain YfbK 7.0 0.0 1.0 0.0523794878273639 0.12605124439272 0.0892153661100419 0.0736717565653561 0 0 0 0 K16260 0.0085714285714285 0.0113960113960113 mxaD; mxaD protein path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 115.0 3.0 0.0 3.0 0.375 S 3.0 5.0 3.0 0.5 COG3832 Chalcone/flavanone-binding_protein_YndB,_AHSA1/START/SRPBCC_domain YndB 8.0 0.375 0.625 0.125974297819996 0.48318670487276 0.304580501346378 0.357212407052764 0 0 0 0 K16263 0.0457142857142857 0.0569800569800569 yjeH; amino acid efflux transporter 331.0 37.0 34.0 2.0 0.925 E 20.0 20.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 40.0 0.5 0.5 0.0336362932372998 0.167863889683997 0.1007500914606484 0.1342275964466971 0 0 0 0 K16264 0.1571428571428571 0.433048433048433 czcD, zitB; cobalt-zinc-cadmium efflux system protein 187.0 242.0 236.0 3.0 0.964143426294821 P 60.0 191.0 2.0 0.97609561752988 COG1230 Co/Zn/Cd_efflux_system_component CzcD 251.0 0.2390438247011952 0.7609561752988048 0.884987319837716 0.815972947738177 0.8504801337879464 0.0690143720995389 1 1 1 1 K16267 0.2028571428571428 0.1339031339031339 zipB; zinc and cadmium transporter 188.0 125.0 0.0 1.0 1.0 P 77.0 48.0 1.0 1.0 COG0428 Zinc_transporter_ZupT ZupT 125.0 0.616 0.384 0.224235995618263 0.944374274614387 0.584305135116325 0.720138278996124 0 0 0 0 K16271 0.0028571428571428 0.0 RLIM, RNF12; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27] 67.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG0800 1.0 1.0 0.0 0 0 0 0 K16276 0.0028571428571428 0.0 K16276, BTS; zinc finger protein-like protein 210.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1940 1.0 1.0 0.0 0 0 0 0 K16290 0.0028571428571428 0.0 XCP; xylem cysteine proteinase [EC:3.4.22.-] 203.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG4870 Cysteine_protease,_C1A_family 1.0 1.0 0.0 0 0 0 0 K16291 0.0 0.1082621082621082 erfK; L,D-transpeptidase ErfK/SrfK 120.0 29.0 6.0 3.0 0.527272727272727 S 0.0 55.0 4.0 0.927272727272727 COG1376 Lipoprotein-anchoring_transpeptidase_ErfK/SrfK ErfK 55.0 0.0 1.0 0.0239685772304464 0.0453942673338708 0.0346814222821586 0.0214256901034244 0 0 0 0 K16293 0.0 0.0227920227920227 psrB; polysulfide reductase chain B 173.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 8.0 0.0 1.0 0.0315006761298566 0.0548047922803604 0.0431527342051085 0.0233041161505037 0 0 0 0 K16294 0.0028571428571428 0.0056980056980056 psrC; polysulfide reductase chain C 255.0 3.0 0.0 1.0 1.0 P 1.0 2.0 1.0 1.0 COG3301 Nitrite/polysulfide_reductase,_membrane_component_NrfD/PsrC NrfD 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K16299 0.0 0.0284900284900284 548.0 13.0 0.0 1.0 1.0 V 0.0 13.0 1.0 1.0 COG4618 ABC-type_protease/lipase_transport_system,_ATPase_and_permease_components ArpD 13.0 0.0 1.0 0.0170568924881408 0.0429902910429191 0.0300235917655299 0.0259333985547783 0 0 0 0 K16300 0.0 0.0284900284900284 425.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 13.0 0.0 1.0 0.0234565945631157 0.0566883807293679 0.0400724876462418 0.0332317861662522 0 0 0 0 K16301 0.0 0.0541310541310541 efeB; deferrochelatase/peroxidase EfeB [EC:1.11.1.-] 352.0 23.0 0.0 1.0 1.0 P 0.0 23.0 1.0 1.0 COG2837 Periplasmic_deferrochelatase/peroxidase_EfeB EfeB 23.0 0.0 1.0 0.015590818541221 0.0729113794682976 0.0442510990047593 0.0573205609270765 0 0 0 0 K16302 0.0085714285714285 0.0056980056980056 CNNM; metal transporter CNNM 315.0 2.0 0.0 3.0 0.4 S 3.0 2.0 1.0 1.0 COG1253 Hemolysin-related_protein,_contains_CBS_domains,_UPF0053_family TlyC 5.0 0.6 0.4 0.0208102040431611 0.722345551716781 0.3715778778799711 0.7015353476736199 0 0 0 0 K16303 0.0 0.0085470085470085 cmtAc; p-cumate 2,3-dioxygenase subunit beta [EC:1.14.12.25] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 154.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 3.0 0.0 1.0 0 0 0 0 K16305 0.1314285714285714 0.0056980056980056 K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11] path:map00010,path:map00030,path:map00051,path:map00400,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 233.0 26.0 1.0 2.0 0.509803921568627 E 49.0 2.0 1.0 1.0 COG1830 Fructose-bisphosphate_aldolase_class_Ia,_DhnA_family FbaB 51.0 0.9607843137254902 0.0392156862745098 0.0368266472198756 0.0152948359590638 0.0260607415894697 0.0215318112608118 0 0 0 0 K16306 0.44 0.0056980056980056 K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10] path:map00010,path:map00030,path:map00051,path:map00400,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 223.0 189.0 184.0 2.0 0.974226804123711 E 192.0 2.0 1.0 1.0 COG1830 Fructose-bisphosphate_aldolase_class_Ia,_DhnA_family FbaB 194.0 0.9896907216494846 0.0103092783505154 0.672062765285313 0.950215170642433 0.811138967963873 0.27815240535712 0 0 0 1 K16317 0.5 0.0085470085470085 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257] 102.0 191.0 0.0 1.0 1.0 J 188.0 3.0 1.0 1.0 COG1901 tRNA_pseudouridine-54_N-methylase TrmY 191.0 0.9842931937172776 0.0157068062827225 0.58648937641931 0.569455386109088 0.577972381264199 0.017033990310222 0 0 0 1 K16318 0.1828571428571428 0.0028490028490028 trm14; tRNA (guanine6-N2)-methyltransferase [EC:2.1.1.256] 239.0 66.0 62.0 2.0 0.942857142857143 J 69.0 1.0 1.0 1.0 COG0116 23S_rRNA_G2445_N2-methylase_RlmL RlmL 70.0 0.9857142857142858 0.0142857142857142 0.98585600826397 0.994034511547756 0.989945259905863 0.0081785032837859 0 0 1 1 K16319 0.0 0.0256410256410256 andAc; anthranilate 1,2-dioxygenase large subunit [EC:1.14.12.1] path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 327.0 10.0 0.0 1.0 1.0 P 0.0 10.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 10.0 0.0 1.0 0.0438617031121464 0.0931410923912771 0.0685013977517117 0.0492793892791307 0 0 0 0 K16320 0.0 0.0113960113960113 andAd; anthranilate 1,2-dioxygenase small subunit [EC:1.14.12.1] path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 153.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 4.0 0.0 1.0 0.0073475274080036 0.025817120490595 0.0165823239492993 0.0184695930825914 0 0 0 0 K16321 0.0 0.0056980056980056 gntP; high-affinity gluconate transporter 432.0 2.0 1.0 2.0 0.666666666666667 EG 0.0 3.0 1.0 1.0 COG2610 H+/gluconate_symporter_GntT_or_related_permease,_GntP/DsdX_family GntT 3.0 0.0 1.0 0 0 0 0 K16322 0.0 0.0142450142450142 pit; low-affinity inorganic phosphate transporter 334.0 8.0 0.0 1.0 1.0 P 0.0 8.0 1.0 1.0 COG0306 Phosphate/sulfate_permease PitA 8.0 0.0 1.0 0.0028415109573533 0.005395188624535 0.0041183497909441 0.0025536776671816 0 0 0 0 K16323 0.0 0.0199430199430199 yxjA, nupG; purine nucleoside transport protein 388.0 8.0 0.0 1.0 1.0 F 0.0 8.0 1.0 1.0 COG1972 Nucleoside_permease_NupC NupC 8.0 0.0 1.0 0.0172307006372894 0.0295991831145427 0.023414941875916 0.0123684824772533 0 0 0 0 K16324 0.0 0.0056980056980056 psuT; putative pseudouridine transporter 415.0 5.0 0.0 1.0 1.0 F 0.0 5.0 1.0 1.0 COG1972 Nucleoside_permease_NupC NupC 5.0 0.0 1.0 9.45160796171256e-12 1.4937786047976298e-11 1.2194697004844428e-11 5.48617808626374e-12 0 0 0 0 K16325 0.0 0.0028490028490028 nupX; nucleoside permease 416.0 2.0 0.0 1.0 1.0 F 0.0 2.0 1.0 1.0 COG1972 Nucleoside_permease_NupC NupC 2.0 0.0 1.0 0 0 0 0 K16326 0.0 0.0028490028490028 yeiL; CRP/FNR family transcriptional regulator, putaive post-exponential-phase nitrogen-starvation regulator 232.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 1.0 0.0 1.0 0 0 0 0 K16327 0.0 0.0113960113960113 K16327; putative LysE/RhtB family amino acid efflux pump 198.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG1280 Threonine/homoserine/homoserine_lactone_efflux_protein RhtB 4.0 0.0 1.0 0.0798194647765853 0.217143823390962 0.1484816440837736 0.1373243586143767 0 0 0 0 K16328 0.0085714285714285 0.1481481481481481 psuK; pseudouridine kinase [EC:2.7.1.83] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 156.0 31.0 20.0 4.0 0.508196721311475 G 3.0 58.0 6.0 0.868852459016393 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 61.0 0.0491803278688524 0.9508196721311476 0.328778360101852 0.238683577221909 0.2837309686618805 0.090094782879943 0 0 0 0 K16329 0.0 0.2193732193732193 psuG; pseudouridylate synthase [EC:4.2.1.70] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 283.0 73.0 70.0 3.0 0.935897435897436 Q 0.0 78.0 1.0 1.0 COG2313 Pseudouridine-5'-phosphate_glycosidase_(pseudoU_degradation) PsuG 78.0 0.0 1.0 0.135744923399508 0.396408035596931 0.2660764794982195 0.260663112197423 0 0 0 0 K16331 0.0114285714285714 0.0142450142450142 ylnA, cysP; sulfate permease 208.0 9.0 0.0 1.0 1.0 P 4.0 5.0 1.0 1.0 COG0306 Phosphate/sulfate_permease PitA 9.0 0.4444444444444444 0.5555555555555556 0.294520284751055 0.220109755456847 0.257315020103951 0.074410529294208 0 0 0 0 K16342 0.0 0.0056980056980056 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4] path:map00564,path:map00565,path:map00590,path:map00591,path:map00592,path:map01100,path:map01110,path:map04010,path:map04014,path:map04072,path:map04217,path:map04270,path:map04370,path:map04611,path:map04664,path:map04666,path:map04724,path:map04726,path:map04730,path:map04750,path:map04912,path:map04913,path:map04921,path:map05231 Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism,Linoleic acid metabolism,alpha-Linolenic acid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,MAPK signaling pathway,Ras signaling pathway,Phospholipase D signaling pathway,Necroptosis,Vascular smooth muscle contraction,VEGF signaling pathway,Platelet activation,Fc epsilon RI signaling pathway,Fc gamma R-mediated phagocytosis,Glutamatergic synapse,Serotonergic synapse,Long-term depression,Inflammatory mediator regulation of TRP channels,GnRH signaling pathway,Ovarian steroidogenesis,Oxytocin signaling pathway,Choline metabolism in cancer 454.0 3.0 2.0 2.0 0.75 I 0.0 4.0 2.0 0.75 KOG1325 4.0 0.0 1.0 8.93457066500364e-09 7.4863756080392e-18 4.4672853362450075e-09 8.934570657517265e-09 0 0 0 0 K16345 0.0 0.0427350427350427 xanP; xanthine permease XanP 428.0 19.0 0.0 1.0 1.0 F 0.0 19.0 2.0 0.947368421052632 COG2233 Xanthine/uracil_permease UraA 19.0 0.0 1.0 0.0363327440707666 0.0626213436337032 0.0494770438522349 0.0262885995629365 0 0 0 0 K16346 0.0 0.0142450142450142 xanQ; xanthine permease XanQ 441.0 9.0 0.0 1.0 1.0 F 0.0 9.0 1.0 1.0 COG2233 Xanthine/uracil_permease UraA 9.0 0.0 1.0 0.0086123888001602 0.011752869715645 0.0101826292579026 0.0031404809154848 0 0 0 0 K16347 0.0 0.0142450142450142 ecnA; entericidin A 40.0 5.0 0.0 1.0 1.0 S 0.0 5.0 2.0 0.8 COG5510 Predicted_small_secreted_protein 5.0 0.0 1.0 0.0773742023709492 0.172934585677164 0.1251543940240566 0.0955603833062147 0 0 0 0 K16348 0.0 0.0199430199430199 ecnB; entericidin B 38.0 6.0 0.0 1.0 1.0 S 0.0 7.0 2.0 0.857142857142857 COG5510 Predicted_small_secreted_protein 7.0 0.0 1.0 0.016283538969962 0.0509054783750996 0.0335945086725308 0.0346219394051376 0 0 0 0 K16362 0.0 0.0028490028490028 FLRT; leucine-rich repeat transmembrane protein FLRT 350.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K16363 0.0028571428571428 0.2136752136752136 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] path:map00061,path:map00540,path:map01100,path:map01212 Fatty acid biosynthesis,Lipopolysaccharide biosynthesis,Metabolic pathways,Fatty acid metabolism 218.0 41.0 8.0 4.0 0.471264367816092 M 1.0 80.0 3.0 0.758620689655172 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl_carrier_protein)_dehydratase FabA 81.0 0.0123456790123456 0.9876543209876544 0.0384089157774614 0.0359200448776004 0.0371644803275309 0.002488870899861 0 0 0 0 K16365 0.0028571428571428 0.0028490028490028 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha 178.0 2.0 0.0 1.0 1.0 S 1.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 2.0 0.5 0.5 0 0 0 0 K16368 0.0057142857142857 0.0028490028490028 DGK1; diacylglycerol kinase (CTP) [EC:2.7.1.174] path:map00564,path:map01100,path:map01110 Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 170.0 3.0 0.0 1.0 1.0 I 2.0 1.0 1.0 1.0 COG0170 Dolichol_kinase SEC59 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K16370 0.0257142857142857 0.1538461538461538 pfkB; 6-phosphofructokinase 2 [EC:2.7.1.11] path:map00010,path:map00030,path:map00051,path:map00052,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Galactose metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 215.0 50.0 32.0 3.0 0.714285714285714 H 9.0 61.0 1.0 1.0 COG1105 1-phosphofructokinase_or_6-phosphofructokinase_II FruK 70.0 0.1285714285714285 0.8714285714285714 0.687207202163087 0.868824943721135 0.778016072942111 0.181617741558048 0 1 0 1 K16371 0.0 0.0484330484330484 gatZ-kbaZ; D-tagatose-1,6-bisphosphate aldolase subunit GatZ/KbaZ path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 393.0 21.0 0.0 1.0 1.0 G 0.0 21.0 1.0 1.0 COG4573 Tagatose-1,6-bisphosphate_aldolase_non-catalytic_subunit_AgaZ/GatZ GatZ 21.0 0.0 1.0 0.880773664615986 0.744130969219612 0.8124523169177991 0.136642695396374 0 0 1 1 K16378 0.0 0.0085470085470085 rapP, fkbP; pipecolate-incorporating enzyme path:map01052 Type I polyketide structures 431.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K16380 0.0 0.0056980056980056 rapN; cytochrome P450 RapN path:map01052 Type I polyketide structures 373.0 4.0 3.0 2.0 0.8 C 0.0 5.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 5.0 0.0 1.0 1.6180193701242001e-21 1.93671534169759e-17 9.684385718173012e-18 1.9365535397605772e-17 0 0 0 0 K16381 0.0 0.0056980056980056 fkbM; 31-O-methyltransferase path:map01052 Type I polyketide structures 256.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K16383 0.0 0.0085470085470085 amphB, nysB; polyene macrolide polyketide synthase, A-type KR domains path:map01052 Type I polyketide structures 1101.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 2.0 0.666666666666667 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 3.0 0.0 1.0 0 0 0 0 K16392 0.0 0.0056980056980056 fscA; candicidin polyketide synthase FscA path:map01052 Type I polyketide structures 1034.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 2.0 0.5 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K16394 0.0 0.0028490028490028 epoA; epothilone polyketide synthase A path:map01052 Type I polyketide structures 2880.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 1.0 0.0 1.0 0 0 0 0 K16396 0.0 0.0028490028490028 epoC; epothilone polyketide synthase C path:map01052 Type I polyketide structures 2146.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 1.0 0.0 1.0 0 0 0 0 K16397 0.0 0.0056980056980056 epoD; epothilone polyketide synthase D path:map01052 Type I polyketide structures 1442.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 2.0 0.5 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 2.0 0.0 1.0 0 0 0 0 K16398 0.0 0.0113960113960113 epoE; epothilone polyketide synthase E path:map01052 Type I polyketide structures 662.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 2.0 0.833333333333333 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0043799625611945 0.0161714635042433 0.0102757130327189 0.0117915009430488 0 0 0 0 K16416 0.0 0.0056980056980056 mxaA; myxalamid-type nonribosomal peptide synthetase MxaA path:map01052 Type I polyketide structures 808.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 4.0 0.0 1.0 2.39869963770889e-13 6.9567893235222e-13 4.677744480615545e-13 4.55808968581331e-13 0 0 0 0 K16417 0.0 0.0113960113960113 mxaC; myxalamid-type polyketide synthase MxaC path:map01052 Type I polyketide structures 662.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 2.0 0.833333333333333 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0045304791472079 0.0159120396099293 0.0102212593785686 0.0113815604627214 0 0 0 0 K16420 0.0 0.0028490028490028 rapA_B_C; rapamycin polyketide synthase A/B/C path:map01052 Type I polyketide structures 2050.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K16421 0.0 0.0227920227920227 hmaS, nocF; 4-hydroxymandelate synthase [EC:1.13.11.46] path:map00261,path:map01055,path:map01100,path:map01110 Monobactam biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 336.0 6.0 2.0 2.0 0.6 C 0.0 10.0 1.0 1.0 COG3185 4-hydroxyphenylpyruvate_dioxygenase_and_related_hemolysins HppD 10.0 0.0 1.0 0.0531579729379363 0.210923677947057 0.1320408254424966 0.1577657050091206 0 0 0 0 K16422 0.0028571428571428 0.0826210826210826 hmo, nocN; 4-hydroxymandelate oxidase [EC:1.1.3.46] path:map00261,path:map01055,path:map01100,path:map01110 Monobactam biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 307.0 32.0 31.0 2.0 0.96969696969697 C 1.0 32.0 2.0 0.939393939393939 COG1304 FMN-dependent_dehydrogenase,_includes_L-lactate_dehydrogenase_and_type_II_isopentenyl_diphosphate_isomerase LldD 33.0 0.0303030303030303 0.9696969696969696 0.0343901993942588 0.481755926277198 0.2580730628357284 0.4473657268829392 0 0 0 0 K16423 0.0 0.0142450142450142 hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] path:map00261,path:map01055,path:map01100,path:map01110 Monobactam biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 383.0 5.0 4.0 3.0 0.714285714285714 EK 0.0 7.0 1.0 1.0 COG1167 DNA-binding_transcriptional_regulator,_MocR_family,_contains_an_aminotransferase_domain ARO8 7.0 0.0 1.0 0.0067960382353169 0.0177262206970938 0.0122611294662053 0.0109301824617769 0 0 0 0 K16424 0.0 0.017094017094017 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] path:map01055,path:map01110 Biosynthesis of vancomycin group antibiotics,Biosynthesis of secondary metabolites 314.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 1.0 1.0 COG3424 Predicted_naringenin-chalcone_synthase BH0617 7.0 0.0 1.0 0.0064544659838958 0.0156528677362415 0.0110536668600686 0.0091984017523456 0 0 0 0 K16425 0.0 0.0028490028490028 dpgB; isomerase DpgB path:map01055,path:map01110 Biosynthesis of vancomycin group antibiotics,Biosynthesis of secondary metabolites 257.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 1.0 0.0 1.0 0 0 0 0 K16426 0.0 0.0056980056980056 dpgD; dehydration protein DpgD path:map01055,path:map01110 Biosynthesis of vancomycin group antibiotics,Biosynthesis of secondary metabolites 250.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 2.0 0.0 1.0 0 0 0 0 K16428 0.0 0.0056980056980056 cepA; nonribosomal peptide synthetase CepA path:map01055 Biosynthesis of vancomycin group antibiotics 1267.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K16429 0.0 0.0056980056980056 cepB; nonribosomal peptide synthetase CepB path:map01055 Biosynthesis of vancomycin group antibiotics 1267.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K16430 0.0 0.0028490028490028 cepC; nonribosomal peptide synthetase CepC path:map01055 Biosynthesis of vancomycin group antibiotics 1203.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K16431 0.0 0.0113960113960113 cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase [EC:1.14.19.-] path:map01055,path:map01059,path:map01100,path:map01110 Biosynthesis of vancomycin group antibiotics,Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 463.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 12.0 0.0 1.0 0.0037469821381657 0.0059042533470149 0.0048256177425903 0.0021572712088492 0 0 0 0 K16434 0.0 0.0085470085470085 cepJ; thioesterase CepJ path:map01055 Biosynthesis of vancomycin group antibiotics 241.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG2021 Homoserine_O-acetyltransferase MET2 3.0 0.0 1.0 0 0 0 0 K16435 0.0 0.0142450142450142 evaA, eryBVI, tylCVI, tylX3, staJ; dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase [EC:4.2.1.159] path:map00523,path:map01055,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 302.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2CCXX 5.0 0.0 1.0 0.0405717950842969 0.0915269720081864 0.0660493835462416 0.0509551769238895 0 0 0 0 K16436 0.0 0.0085470085470085 evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106] path:map00523,path:map01055,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 359.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 3.0 0.0 1.0 0 0 0 0 K16437 0.0 0.0284900284900284 evaC; methylation protein EvaC path:map01055,path:map01100,path:map01110,path:map01250 Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 228.0 7.0 5.0 3.0 0.7 Q 0.0 10.0 2.0 0.7 COG0500 SAM-dependent_methyltransferase SmtA 10.0 0.0 1.0 0.0086620081500435 0.0502099458537649 0.0294359770019042 0.0415479377037213 0 0 0 0 K16438 0.0 0.0113960113960113 evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase [EC:5.1.3.-] path:map00404,path:map00523,path:map01055,path:map01100,path:map01110,path:map01250 Staurosporine biosynthesis,Polyketide sugar unit biosynthesis,Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 192.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG1898 dTDP-4-dehydrorhamnose_3,5-epimerase_or_related_enzyme RfbC 4.0 0.0 1.0 8.97276576371592e-05 0.0007330656433137 0.0004113966504754 0.0006433379856765 0 0 0 0 K16439 0.0028571428571428 0.0113960113960113 evaE; reductase EvaE path:map01055,path:map01100,path:map01110,path:map01250 Biosynthesis of vancomycin group antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 315.0 4.0 2.0 2.0 0.666666666666667 M 1.0 5.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 6.0 0.1666666666666666 0.8333333333333334 6.01669823565593e-12 0.073466558076852 0.0367332790414343 0.0734665580708353 0 0 0 0 K16440 0.0 0.0028490028490028 gtfA; chloroorienticin B synthase [EC:2.4.1.311] path:map01055 Biosynthesis of vancomycin group antibiotics 198.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K16444 0.0 0.0199430199430199 gtfB, gtfE; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] path:map01055 Biosynthesis of vancomycin group antibiotics 350.0 7.0 0.0 1.0 1.0 CG 0.0 7.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 7.0 0.0 1.0 0.0857379990038942 0.151379036797454 0.118558517900674 0.0656410377935597 0 0 0 0 K16474 0.0057142857142857 0.0 IFT88; intraflagellar transport protein 88 257.0 2.0 0.0 1.0 1.0 K 2.0 0.0 1.0 1.0 COG1161 Ribosome_biogenesis_GTPase_RbgA RbgA 2.0 1.0 0.0 0 0 0 0 K16509 0.0 0.0541310541310541 spxA; regulatory protein spx 129.0 15.0 1.0 2.0 0.517241379310345 P 0.0 29.0 2.0 0.96551724137931 COG1393 Arsenate_reductase_or_related_protein,_glutaredoxin_family ArsC 29.0 0.0 1.0 0.0082617646629394 0.0070001322348681 0.0076309484489037 0.0012616324280713 0 0 0 0 K16511 0.0 0.0655270655270655 mecA1_2; adapter protein MecA 1/2 136.0 28.0 0.0 1.0 1.0 NOT 0.0 28.0 1.0 1.0 COG4862 Negative_regulator_MecA_of_genetic_competence,_sporulation_and_motility MecA 28.0 0.0 1.0 0 0 0 0 K16514 0.0 0.0341880341880341 galD; 4-oxalomesaconate tautomerase [EC:5.3.2.8] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 344.0 17.0 0.0 1.0 1.0 S 0.0 17.0 1.0 1.0 COG2828 2-Methylaconitate_cis-trans-isomerase_PrpF_(2-methyl_citrate_pathway) PrpF 17.0 0.0 1.0 0.032770020066562 0.044929024087891 0.0388495220772265 0.0121590040213289 0 0 0 0 K16515 0.0028571428571428 0.037037037037037 galB; 4-oxalomesaconate hydratase [EC:4.2.1.83] path:map00362,path:map01100 Benzoate degradation,Metabolic pathways 232.0 17.0 0.0 1.0 1.0 S 2.0 15.0 1.0 1.0 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 17.0 0.1176470588235294 0.8823529411764706 0.0280226512406533 0.327698648792642 0.1778606500166476 0.2996759975519887 0 0 0 0 K16516 0.0 0.0085470085470085 galR; LysR family transcriptional regulator, regulator for genes of the gallate degradation pathway 314.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 3.0 0.0 1.0 0 0 0 0 K16531 0.0 0.0028490028490028 BBS4; Bardet-Biedl syndrome 4 protein 424.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K16552 0.0 0.0227920227920227 exoF; polysaccharide biosynthesis/export protein ExoF 178.0 6.0 5.0 3.0 0.75 M 0.0 8.0 3.0 0.75 COG1596 Periplasmic_protein_Wza_involved_in_polysaccharide_export,_contains_SLBB_domain_of_the_beta-grasp_fold Wza 8.0 0.0 1.0 0.07915433025113 0.1901375367237 0.134645933487415 0.11098320647257 0 0 0 0 K16554 0.0028571428571428 0.2649572649572649 exoP, vpsO; polysaccharide biosynthesis transport protein [EC:2.7.10.3] path:map05111 Biofilm formation - Vibrio cholerae 92.0 91.0 50.0 4.0 0.565217391304348 D 1.0 159.0 3.0 0.732919254658385 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 160.0 0.00625 0.99375 0.157064453439396 0.182570226092415 0.1698173397659055 0.0255057726530189 0 0 0 0 K16555 0.0 0.0341880341880341 exoO; succinoglycan biosynthesis protein ExoO [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 189.0 8.0 6.0 3.0 0.666666666666667 M 0.0 12.0 4.0 0.333333333333333 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 12.0 0.0 1.0 0.036409530939492 0.0691418295566298 0.0527756802480609 0.0327322986171378 0 0 0 0 K16556 0.0 0.0113960113960113 exoM; succinoglycan biosynthesis protein ExoM [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 256.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 4.0 0.0 1.0 0.0307675836246035 0.0680100034587652 0.0493887935416843 0.0372424198341617 0 0 0 0 K16557 0.0142857142857142 0.0256410256410256 exoA; succinoglycan biosynthesis protein ExoA [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 264.0 16.0 15.0 2.0 0.941176470588235 M 5.0 10.0 3.0 0.823529411764706 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 15.0 0.3333333333333333 0.6666666666666666 0.100013073113805 0.838526762131191 0.469269917622498 0.738513689017386 0 0 0 0 K16558 0.0 0.0085470085470085 exoL; succinoglycan biosynthesis protein ExoL [EC:2.-.-.-] path:map00543 Exopolysaccharide biosynthesis 332.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 3.0 0.0 1.0 0 0 0 0 K16559 0.0 0.0142450142450142 exoK; endo-1,3-1,4-beta-glycanase ExoK [EC:3.2.1.-] 221.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG2273 Beta-glucanase,_GH16_family BglS 5.0 0.0 1.0 0.0803737387587787 0.201115376971722 0.1407445578652503 0.1207416382129432 0 0 0 0 K16560 0.0 0.0028490028490028 exoH; succinoglycan biosynthesis protein ExoH path:map00543 Exopolysaccharide biosynthesis 369.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1835 Peptidoglycan/LPS_O-acetylase_OafA/YrhL,_contains_acyltransferase_and_SGNH-hydrolase_domains OafA 1.0 0.0 1.0 0 0 0 0 K16561 0.0 0.017094017094017 exoI; succinoglycan biosynthesis protein ExoI 154.0 6.0 0.0 1.0 1.0 L 0.0 6.0 1.0 1.0 COG1525 Endonuclease_YncB,_thermonuclease_family YncB 6.0 0.0 1.0 0.0513912356779521 0.213242020563515 0.1323166281207335 0.1618507848855629 0 0 0 0 K16562 0.0 0.0056980056980056 exoW; succinoglycan biosynthesis protein ExoW [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 293.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 2.0 0.0 1.0 0 0 0 0 K16563 0.0 0.0028490028490028 exoV; succinoglycan biosynthesis protein ExoV path:map00543 Exopolysaccharide biosynthesis 301.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2327 Polysaccharide_pyruvyl_transferase_family_protein_WcaK_(colanic_acid_biosynthesis) WcaK 1.0 0.0 1.0 0 0 0 0 K16564 0.0 0.0085470085470085 exoU; succinoglycan biosynthesis protein ExoU [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 286.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 3.0 0.0 1.0 0 0 0 0 K16565 0.0 0.0028490028490028 exoX, syrA; exopolysaccharide production regulatory protein 98.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2967N 1.0 0.0 1.0 0 0 0 0 K16566 0.0 0.0284900284900284 exoY; exopolysaccharide production protein ExoY path:map00543 Exopolysaccharide biosynthesis 208.0 11.0 0.0 1.0 1.0 M 0.0 11.0 2.0 0.636363636363636 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 11.0 0.0 1.0 0.712555986515164 0.137049310818143 0.4248026486666535 0.5755066756970211 0 0 0 1 K16567 0.0 0.0142450142450142 exoQ; exopolysaccharide production protein ExoQ 366.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG3307 O-antigen_ligase RfaL 5.0 0.0 1.0 0.0729678951348907 0.155573042606012 0.1142704688704513 0.0826051474711213 0 0 0 0 K16568 0.0 0.0142450142450142 exoZ; exopolysaccharide production protein ExoZ path:map00543 Exopolysaccharide biosynthesis 327.0 5.0 0.0 1.0 1.0 I 0.0 5.0 1.0 1.0 COG1835 Peptidoglycan/LPS_O-acetylase_OafA/YrhL,_contains_acyltransferase_and_SGNH-hydrolase_domains OafA 5.0 0.0 1.0 0.0285089184108181 0.126368608027691 0.0774387632192545 0.0978596896168729 0 0 0 0 K16575 0.0028571428571428 0.0 ACTR1, ARP1; centractin path:map05014,path:map05016,path:map05022,path:map05132 Amyotrophic lateral sclerosis,Huntington disease,Pathways of neurodegeneration - multiple diseases,Salmonella infection 477.0 1.0 0.0 1.0 1.0 Z 1.0 0.0 1.0 1.0 COG5017 UDP-N-acetylglucosamine_transferase_subunit_ALG13 1.0 1.0 0.0 0 0 0 0 K16593 0.0 0.0085470085470085 bioI, CYP107H; pimeloyl-[acyl-carrier protein] synthase [EC:1.14.14.46] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 317.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 3.0 0.0 1.0 0 0 0 0 K16637 0.0 0.0085470085470085 K16637, exoY; adenylate cyclase ExoY 338.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG3064 Membrane_protein_TolA_involved_in_colicin_uptake TolA 6.0 0.0 1.0 2.92980859240772e-12 5.3190333853716196e-12 4.12442098888967e-12 2.3892247929639005e-12 0 0 0 0 K16638 0.0 0.0056980056980056 exoU; exoenzyme U 21.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG1752 Predicted_acylesterase/phospholipase_RssA,_containd_patatin_domain RssA 4.0 0.0 1.0 1.35921553186117e-12 2.841773191623e-12 2.100494361742085e-12 1.48255765976183e-12 0 0 0 0 K16640 0.02 0.0 ssh7; DNA-binding protein 7 [EC:3.1.27.-] 61.0 12.0 0.0 1.0 1.0 J 12.0 0.0 1.0 1.0 arCOG05888 12.0 1.0 0.0 3.206793899611809e-16 1.26646993642547e-14 6.492689377107941e-15 1.234401997429352e-14 0 0 0 0 K16645 0.0 0.0199430199430199 hbhA; heparin binding hemagglutinin HbhA 190.0 5.0 0.0 1.0 1.0 S 0.0 7.0 3.0 0.714285714285714 2EBKM 7.0 0.0 1.0 4.33303776861984e-08 1.59044196122211e-05 7.97387499495365e-06 1.58610892345349e-05 0 0 0 0 K16647 0.0 0.0085470085470085 aftC; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.47] path:map00571,path:map00572 Lipoarabinomannan (LAM) biosynthesis,Arabinogalactan biosynthesis - Mycobacterium 352.0 4.0 0.0 1.0 1.0 S 0.0 4.0 2.0 0.75 2F13Q 4.0 0.0 1.0 1.71308078178131e-06 4.88660887359356e-06 3.2998448276874352e-06 3.17352809181225e-06 0 0 0 0 K16648 0.0 0.0598290598290598 aftD; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.-] path:map00571,path:map00572 Lipoarabinomannan (LAM) biosynthesis,Arabinogalactan biosynthesis - Mycobacterium 323.0 8.0 3.0 5.0 0.363636363636364 S 0.0 22.0 5.0 0.454545454545455 COG1287 Asparagine_N-glycosylation_enzyme,_membrane_subunit_Stt3 Stt3 22.0 0.0 1.0 0.0154677978301816 0.109790927245477 0.0626293625378293 0.0943231294152954 0 0 0 0 K16649 0.0057142857142857 0.0284900284900284 glft1; rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase [EC:2.4.1.287] path:map00572,path:map01100 Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 268.0 9.0 7.0 3.0 0.75 S 2.0 10.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 12.0 0.1666666666666666 0.8333333333333334 0.135703388708589 0.060549632604788 0.0981265106566885 0.075153756103801 0 0 0 0 K16650 0.0 0.0313390313390313 glft2; galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase [EC:2.4.1.288] path:map00572,path:map01100 Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 565.0 9.0 7.0 2.0 0.818181818181818 S 0.0 11.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 11.0 0.0 1.0 0.0106957540611731 0.0267499288397672 0.0187228414504701 0.0160541747785941 0 0 0 0 K16651 0.0 0.0484330484330484 pduX; L-threonine kinase [EC:2.7.1.177] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 231.0 17.0 0.0 1.0 1.0 Q 0.0 17.0 1.0 1.0 COG4542 PduX_protein_involved_in_propanediol_utilization_and_related_proteins PduX 17.0 0.0 1.0 0.0080166231454776 0.130805540698327 0.0694110819219023 0.1227889175528494 0 0 0 0 K16652 0.0 0.037037037037037 dprE2; decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase [EC:1.1.1.333] 244.0 12.0 6.0 2.0 0.666666666666667 S 0.0 18.0 2.0 0.666666666666667 COG0300 Short-chain_dehydrogenase YqjQ 18.0 0.0 1.0 0.0048979149140407 0.0161354169879273 0.010516665950984 0.0112375020738865 0 0 0 0 K16653 0.0 0.0541310541310541 dprE1; decaprenylphospho-beta-D-ribofuranose 2-oxidase [EC:1.1.98.3] 427.0 19.0 0.0 1.0 1.0 C 0.0 19.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 19.0 0.0 1.0 0.0177968900899006 0.0280369343732327 0.0229169122315666 0.0102400442833321 0 0 0 0 K16669 0.0057142857142857 0.0 FAT4; protocadherin Fat 4 path:map04391,path:map04392 Hippo signaling pathway - fly,Hippo signaling pathway - multiple species 183.0 2.0 0.0 1.0 1.0 M 2.0 0.0 1.0 1.0 KOG3638 2.0 1.0 0.0 0 0 0 0 K16692 0.0 0.1538461538461538 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] path:map02020 Two-component system 233.0 43.0 28.0 4.0 0.614285714285714 D 0.0 70.0 4.0 0.942857142857143 COG0489 Fe-S_cluster_carrier_ATPase,_Mrp/ApbC/NBP35_family Mrp 70.0 0.0 1.0 0.0181274673982032 0.11659549619364 0.0673614817959216 0.0984680287954368 0 0 0 0 K16693 0.0 0.0113960113960113 wzxE; enterobacterial common antigen flippase 409.0 4.0 0.0 1.0 1.0 U 0.0 4.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 4.0 0.0 1.0 5.21947222136878e-12 5.44819047283168e-08 2.7243562100269085e-08 5.4476685256095436e-08 0 0 0 0 K16694 0.0028571428571428 0.0142450142450142 tuaB; teichuronic acid exporter 319.0 7.0 0.0 1.0 1.0 S 1.0 6.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 7.0 0.1428571428571428 0.8571428571428571 0.02483877755973 0.0679959098846056 0.0464173437221678 0.0431571323248756 0 0 0 0 K16695 0.0285714285714285 0.037037037037037 wzxC; lipopolysaccharide exporter 399.0 27.0 23.0 2.0 0.870967741935484 S 15.0 16.0 2.0 0.967741935483871 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 31.0 0.4838709677419355 0.5161290322580645 0.0115246469129021 0.0379173106126938 0.0247209787627979 0.0263926636997917 0 0 0 0 K16696 0.0 0.0028490028490028 amsL; exopolysaccharide (amylovoran) exporter 446.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 1.0 0.0 1.0 0 0 0 0 K16697 0.0028571428571428 0.0199430199430199 tuaC; teichuronic acid biosynthesis glycosyltransferase TuaC [EC:2.4.-.-] 291.0 8.0 7.0 2.0 0.888888888888889 M 1.0 8.0 2.0 0.888888888888889 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 9.0 0.1111111111111111 0.8888888888888888 0.065012811688401 0.1274342671099 0.0962235393991505 0.0624214554214989 0 0 0 0 K16698 0.0028571428571428 0.0427350427350427 tuaG; teichuronic acid biosynthesis glycosyltransferase TuaG [EC:2.4.-.-] 237.0 16.0 0.0 1.0 1.0 M 1.0 15.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 16.0 0.0625 0.9375 0.0264245413510867 0.160922965377061 0.0936737533640738 0.1344984240259742 0 0 0 0 K16699 0.0 0.0028490028490028 tuaH; teichuronic acid biosynthesis glycosyltransferase TuaH [EC:2.4.-.-] 376.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K16700 0.0 0.0056980056980056 amsB, cpsE; amylovoran/stewartan biosynthesis glycosyltransferase AmsB/CpsE [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 287.0 1.0 0.0 2.0 0.5 V 0.0 2.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 2.0 0.0 1.0 0 0 0 0 K16701 0.0 0.0056980056980056 amsD; amylovoran biosynthesis glycosyltransferase AmsD [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 342.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 2.0 0.0 1.0 0 0 0 0 K16702 0.0 0.0085470085470085 amsE; amylovoran biosynthesis glycosyltransferase AmsE [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 253.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 3.0 0.0 1.0 0 0 0 0 K16703 0.0114285714285714 0.0427350427350427 wcaL, amsK, cpsK; colanic acid/amylovoran/stewartan biosynthesis glycosyltransferase WcaL/AmsK/CpsK [EC:2.4.-.-] path:map00543 Exopolysaccharide biosynthesis 254.0 24.0 23.0 2.0 0.96 M 5.0 20.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 25.0 0.2 0.8 0.0264125421365764 0.241414790091822 0.1339136661141992 0.2150022479552456 0 0 0 0 K16704 0.0028571428571428 0.0313390313390313 rffC, wecD; dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase [EC:2.3.1.210] path:map00541,path:map01100,path:map01250 O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 103.0 12.0 0.0 1.0 1.0 K 1.0 11.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 12.0 0.0833333333333333 0.9166666666666666 0.0284307571342288 0.0603299317158881 0.0443803444250584 0.0318991745816593 0 0 0 0 K16705 0.0028571428571428 0.037037037037037 tuaE; teichuronic acid biosynthesis protein TuaE 258.0 17.0 0.0 1.0 1.0 M 1.0 16.0 3.0 0.882352941176471 COG3307 O-antigen_ligase RfaL 17.0 0.0588235294117647 0.9411764705882352 0.547270161107826 0.0976682046744979 0.3224691828911619 0.4496019564333281 0 0 0 1 K16706 0.0 0.0056980056980056 tuaF; teichuronic acid biosynthesis protein TuaF 152.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG3206 Exopolysaccharide_export_protein/domain_GumC/Wzc1 GumC 2.0 0.0 1.0 0 0 0 0 K16707 0.0 0.0199430199430199 amsG, cpsA; UDP-galactose-lipid carrier transferase path:map00543 Exopolysaccharide biosynthesis 394.0 8.0 0.0 1.0 1.0 M 0.0 8.0 2.0 0.5 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 8.0 0.0 1.0 0.887925960069806 0.153418585339003 0.5206722727044044 0.734507374730803 0 0 1 1 K16708 0.0 0.0056980056980056 amsC; amylovoran biosynthesis protein AmsC 357.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DR4Q 2.0 0.0 1.0 0 0 0 0 K16709 0.0 0.0028490028490028 amsF; amylovoran biosynthesis protein AmsF 743.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG5434 Polygalacturonase Pgu1 1.0 0.0 1.0 0 0 0 0 K16710 0.0142857142857142 0.0484330484330484 wcaK, amsJ; colanic acid/amylovoran biosynthesis protein WcaK/AmsJ path:map00543 Exopolysaccharide biosynthesis 110.0 25.0 0.0 1.0 1.0 S 5.0 20.0 2.0 0.92 COG2327 Polysaccharide_pyruvyl_transferase_family_protein_WcaK_(colanic_acid_biosynthesis) WcaK 25.0 0.2 0.8 0.048898372544121 0.252199024973162 0.1505486987586415 0.203300652429041 0 0 0 0 K16711 0.0 0.0028490028490028 wcaM; colanic acid biosynthesis protein WcaM 464.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 2C3PH 1.0 0.0 1.0 0 0 0 0 K16712 0.0 0.0028490028490028 epsE; EPS I polysaccharide export inner membrane protein EpsE path:map02020 Two-component system 435.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 1.0 0.0 1.0 0 0 0 0 K16733 0.0085714285714285 0.0 RACGAP1, Tum; Rac GTPase-activating protein 1 306.0 3.0 0.0 1.0 1.0 L 3.0 0.0 1.0 1.0 COG1467 Eukaryotic-type_DNA_primase,_catalytic_(small)_subunit PRI1 3.0 1.0 0.0 0 0 0 0 K16781 0.0 0.0028490028490028 TTC8, BBS8; tetratricopeptide repeat protein 8 204.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K16783 0.14 0.1566951566951566 bioN; biotin transport system permease protein path:map02010 ABC transporters 158.0 105.0 104.0 2.0 0.990566037735849 P 50.0 58.0 2.0 0.981481481481482 COG0619 ECF-type_transporter_transmembrane_protein_EcfT EcfT 108.0 0.4629629629629629 0.5370370370370371 0.0061566446310255 0.0153534654699328 0.0107550550504791 0.0091968208389073 0 0 0 0 K16784 0.1257142857142857 0.1481481481481481 bioM; biotin transport system ATP-binding protein [EC:7.6.2.-] path:map02010 ABC transporters 203.0 61.0 24.0 3.0 0.61 P 44.0 56.0 2.0 0.91 COG1122 Energy-coupling_factor_transporter_ATP-binding_protein_EcfA2 EcfA2 100.0 0.44 0.56 0.859781979189785 0.230725860524719 0.545253919857252 0.629056118665066 1 1 1 1 K16785 0.3714285714285714 0.4216524216524216 ecfT; energy-coupling factor transport system permease protein path:map02010 ABC transporters 22.0 482.0 454.0 8.0 0.8909426987061 P 242.0 307.0 12.0 0.85045045045045 COG0619 ECF-type_transporter_transmembrane_protein_EcfT EcfT 549.0 0.4408014571948998 0.5591985428051002 0.177257030459765 0.705501868361752 0.4413794494107585 0.528244837901987 0 0 0 0 K16786 0.4 0.433048433048433 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] path:map02010 ABC transporters 52.0 439.0 390.0 12.0 0.716150081566069 P 264.0 343.0 19.0 0.634584013050571 COG1122 Energy-coupling_factor_transporter_ATP-binding_protein_EcfA2 EcfA2 607.0 0.4349258649093904 0.5650741350906096 0.205569546900573 0.729035940838785 0.4673027438696789 0.523466393938212 0 0 0 0 K16787 0.4057142857142857 0.4415954415954416 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] path:map02010 ABC transporters 34.0 505.0 450.0 13.0 0.743740795287187 P 306.0 358.0 19.0 0.677466863033873 COG1122 Energy-coupling_factor_transporter_ATP-binding_protein_EcfA2 EcfA2 664.0 0.4608433734939759 0.5391566265060241 0.369889366929976 0.66285442498072 0.516371895955348 0.292965058050744 0 0 0 0 K16788 0.0 0.0797720797720797 niaX; niacin transporter 91.0 14.0 7.0 2.0 0.666666666666667 S 0.0 30.0 3.0 0.466666666666667 298ZI 30.0 0.0 1.0 0.211850303300923 0.158059714733435 0.1849550090171789 0.053790588567488 0 0 0 0 K16789 0.0171428571428571 0.1054131054131054 thiT; thiamine transporter 125.0 45.0 0.0 1.0 1.0 S 6.0 39.0 1.0 1.0 COG3859 Thiamine_transporter_ThiT ThiT 45.0 0.1333333333333333 0.8666666666666667 0.284676214521947 0.119410606797947 0.202043410659947 0.165265607724 0 0 0 0 K16792 0.1657142857142857 0.037037037037037 aksD; methanogen homoaconitase large subunit [EC:4.2.1.114] path:map00300,path:map00680,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230,path:map01240 Lysine biosynthesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 374.0 76.0 70.0 2.0 0.926829268292683 E 69.0 13.0 1.0 1.0 COG0065 Homoaconitase/3-isopropylmalate_dehydratase_large_subunit LeuC 82.0 0.8414634146341463 0.1585365853658536 0.727886367384205 0.122305998605212 0.4250961829947084 0.605580368778993 0 1 0 1 K16793 0.1314285714285714 0.0142450142450142 aksE; methanogen homoaconitase small subunit [EC:4.2.1.114] path:map00300,path:map00680,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230,path:map01240 Lysine biosynthesis,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of cofactors 138.0 58.0 0.0 1.0 1.0 E 53.0 5.0 1.0 1.0 COG0066 3-isopropylmalate_dehydratase_small_subunit LeuD 58.0 0.913793103448276 0.0862068965517241 0.0120691364208026 0.0211374803080284 0.0166033083644155 0.0090683438872258 0 0 0 0 K16838 0.0142857142857142 0.0028490028490028 pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:1.7.3.3 4.1.1.97] path:map00230,path:map00232,path:map01100,path:map01120 Purine metabolism,Caffeine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 316.0 5.0 4.0 2.0 0.833333333333333 F 5.0 1.0 1.0 1.0 COG3648 Uricase_(urate_oxidase) UriC 6.0 0.8333333333333334 0.1666666666666666 0.10062742800331 0.0786031730095095 0.0896153005064097 0.0220242549938004 0 0 0 0 K16839 0.0 0.0284900284900284 hpxO; FAD-dependent urate hydroxylase [EC:1.14.13.113] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 359.0 8.0 6.0 2.0 0.8 CH 0.0 10.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 10.0 0.0 1.0 0.0447273095367716 0.100532407061085 0.0726298582989283 0.0558050975243134 0 0 0 0 K16840 0.0 0.0598290598290598 hpxQ; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 159.0 23.0 0.0 1.0 1.0 S 0.0 23.0 1.0 1.0 COG3195 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline_(OHCU)_decarboxylase_(uric_acid_degradation) PucL 23.0 0.0 1.0 0.0125112556057427 0.0317474311675169 0.0221293433866298 0.0192361755617742 0 0 0 0 K16841 0.0542857142857142 0.0826210826210826 hpxA; allantoin racemase [EC:5.1.99.3] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 143.0 46.0 25.0 2.0 0.686567164179104 E 30.0 37.0 2.0 0.686567164179105 COG4126 Asp/Glu/hydantoin_racemase Dcg1 67.0 0.4477611940298507 0.5522388059701493 0.0564754860299356 0.523620456890568 0.2900479714602518 0.4671449708606324 0 0 0 0 K16842 0.0 0.017094017094017 hpxB; allantoinase [EC:3.5.2.5] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 302.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 6.0 0.0 1.0 0.069018266148918 0.127234466411896 0.098126366280407 0.058216200262978 0 0 0 0 K16843 0.0114285714285714 0.0769230769230769 slcC; (S)-sulfolactate dehydrogenase [EC:1.1.1.310] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 220.0 14.0 3.0 4.0 0.411764705882353 C 4.0 30.0 2.0 0.558823529411765 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 34.0 0.1176470588235294 0.8823529411764706 0.081826693580392 0.846409179154919 0.4641179363676554 0.764582485574527 0 0 0 0 K16844 0.0057142857142857 0.0512820512820512 comC; (2R)-3-sulfolactate dehydrogenase (NADP+) [EC:1.1.1.338] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 308.0 20.0 0.0 1.0 1.0 C 2.0 18.0 1.0 1.0 COG2055 Malate/lactate/ureidoglycolate_dehydrogenase,_LDH2_family AllD 20.0 0.1 0.9 0.0455276230050323 0.0763570332229676 0.0609423281139999 0.0308294102179352 0 0 0 0 K16845 0.04 0.0541310541310541 suyA; (2R)-sulfolactate sulfo-lyase subunit alpha [EC:4.4.1.24] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 78.0 34.0 33.0 2.0 0.971428571428571 G 15.0 20.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 35.0 0.4285714285714285 0.5714285714285714 0.862299034990455 0.944956205685514 0.9036276203379844 0.0826571706950589 1 1 1 1 K16846 0.0514285714285714 0.0541310541310541 suyB; (2R)-sulfolactate sulfo-lyase subunit beta [EC:4.4.1.24] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 350.0 47.0 0.0 1.0 1.0 G 23.0 24.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 47.0 0.4893617021276595 0.5106382978723404 0.952973382403832 0.936115151423826 0.944544266913829 0.016858230980006 1 1 1 1 K16849 0.0742857142857142 0.0341880341880341 uxaA1; altronate dehydratase small subunit [EC:4.2.1.7] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 71.0 44.0 0.0 1.0 1.0 G 28.0 15.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 43.0 0.6511627906976745 0.3488372093023256 0.977294801542427 0.952239232406562 0.9647670169744944 0.0250555691358649 1 1 1 1 K16850 0.0714285714285714 0.0484330484330484 uxaA2; altronate dehydratase large subunit [EC:4.2.1.7] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 347.0 56.0 0.0 1.0 1.0 G 35.0 21.0 1.0 1.0 COG2721 Altronate_dehydratase UxaA 56.0 0.625 0.375 0.99103340476372 0.974947471022598 0.9829904378931592 0.0160859337411219 1 1 1 1 K16855 0.0 0.0142450142450142 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64] path:map00230,path:map01100,path:map01232,path:map03018 Purine metabolism,Metabolic pathways,Nucleotide metabolism,RNA degradation 147.0 5.0 0.0 1.0 1.0 F 0.0 5.0 1.0 1.0 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 5.0 0.0 1.0 0.221646934804325 0.332954491782728 0.2773007132935265 0.111307556978403 0 0 0 0 K16856 0.0 0.0227920227920227 ugl; ureidoglycolate lyase [EC:4.3.2.3] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 278.0 9.0 0.0 1.0 1.0 Q 0.0 9.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 9.0 0.0 1.0 0.0035372896737128 0.0068779805250365 0.0052076350993746 0.0033406908513237 0 0 0 0 K16868 0.04 0.0826210826210826 tehB; tellurite methyltransferase [EC:2.1.1.265] 22.0 18.0 4.0 7.0 0.382978723404255 Q 15.0 32.0 6.0 0.51063829787234 COG0500 SAM-dependent_methyltransferase SmtA 47.0 0.3191489361702128 0.6808510638297872 0.0235970395255347 0.248240889406881 0.1359189644662078 0.2246438498813462 0 0 0 0 K16869 0.0114285714285714 0.0512820512820512 lipL; octanoyl-[GcvH]:protein N-octanoyltransferase [EC:2.3.1.204] path:map00785,path:map01100,path:map01240 Lipoic acid metabolism,Metabolic pathways,Biosynthesis of cofactors 155.0 13.0 2.0 2.0 0.541666666666667 H 4.0 20.0 2.0 0.541666666666667 COG0095 Lipoate-protein_ligase_A LplA 24.0 0.1666666666666666 0.8333333333333334 0.0648306175668512 0.370290410341356 0.2175605139541036 0.3054597927745048 0 0 0 0 K16870 0.0028571428571428 0.0455840455840455 wbbL; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase [EC:2.4.1.289] path:map00572,path:map01100 Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 225.0 15.0 12.0 3.0 0.789473684210526 S 1.0 18.0 2.0 0.894736842105263 COG1216 Glycosyltransferase,_GT2_family WcaE 19.0 0.0526315789473684 0.9473684210526316 0.0107737105949581 0.0267211302891025 0.0187474204420303 0.0159474196941444 0 0 0 0 K16871 0.0 0.0398860398860398 POP2; 4-aminobutyrate---pyruvate transaminase [EC:2.6.1.96] path:map00250,path:map00650,path:map01100,path:map01120 Alanine, aspartate and glutamate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 443.0 16.0 13.0 2.0 0.842105263157895 H 0.0 19.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 19.0 0.0 1.0 0.0200251027477436 0.0443040108859346 0.0321645568168391 0.024278908138191 0 0 0 0 K16872 0.0 0.0512820512820512 E2.3.1.207; beta-ketodecanoyl-[acyl-carrier-protein] synthase [EC:2.3.1.207] 370.0 18.0 16.0 2.0 0.9 I 0.0 20.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 20.0 0.0 1.0 0.0030447222769818 0.01273171617896 0.0078882192279709 0.0096869939019782 0 0 0 0 K16873 0.0 0.017094017094017 hmfH; 5-(hydroxymethyl)furfural/furfural oxidase [EC:1.1.3.47 1.1.3.-] path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 557.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 6.0 0.0 1.0 0.0180467315434436 0.0641958281322353 0.0411212798378394 0.0461490965887917 0 0 0 0 K16874 0.0057142857142857 0.0427350427350427 hmfF; 2,5-furandicarboxylate decarboxylase 1 path:map00365,path:map01120 Furfural degradation,Microbial metabolism in diverse environments 413.0 18.0 0.0 1.0 1.0 H 2.0 16.0 1.0 1.0 COG0043 3-polyprenyl-4-hydroxybenzoate_decarboxylase UbiD 18.0 0.1111111111111111 0.8888888888888888 0.0707808990131466 0.247540441125067 0.1591606700691068 0.1767595421119204 0 0 0 0 K16875 0.0 0.0113960113960113 hmfG; 2,5-furandicarboxylate decarboxylase 2 path:map00365,path:map01120 Furfural degradation,Microbial metabolism in diverse environments 184.0 4.0 0.0 1.0 1.0 H 0.0 4.0 1.0 1.0 COG0163 Flavin_prenyltransferase_UbiX UbiX 4.0 0.0 1.0 0.0131003674481456 0.0627638270104262 0.0379320972292859 0.0496634595622806 0 0 0 0 K16876 0.0 0.0313390313390313 hmfD; 2-furoate---CoA ligase [EC:6.2.1.31] path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 460.0 13.0 0.0 1.0 1.0 IQ 0.0 13.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 13.0 0.0 1.0 0.0096986851565437 0.023140565424708 0.0164196252906258 0.0134418802681643 0 0 0 0 K16877 0.0257142857142857 0.017094017094017 hmfA; 2-furoyl-CoA dehydrogenase large subunit [EC:1.3.99.8] path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 219.0 21.0 0.0 1.0 1.0 C 12.0 7.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 19.0 0.631578947368421 0.3684210526315789 0.178145421622147 0.0842431929815303 0.1311943073018386 0.0939022286406167 0 0 0 0 K16878 0.0 0.0199430199430199 hmfB; 2-furoyl-CoA dehydrogenase FAD binding subunit [EC:1.3.99.8] path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 264.0 6.0 5.0 2.0 0.857142857142857 C 0.0 7.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 7.0 0.0 1.0 0.0551027146417559 0.1254656848032 0.0902841997224779 0.0703629701614441 0 0 0 0 K16879 0.0 0.0284900284900284 hmfC; 2-furoyl-CoA dehydrogenase 2Fe-2S iron sulfur subunit [EC:1.3.99.8] path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 154.0 10.0 0.0 1.0 1.0 C 0.0 10.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 10.0 0.0 1.0 0.448325663633265 0.219700566840816 0.3340131152370404 0.228625096792449 0 0 0 0 K16880 0.0085714285714285 0.0284900284900284 hmfE; 2-oxoglutaroyl-CoA hydrolase path:map00365,path:map01100,path:map01120 Furfural degradation,Metabolic pathways,Microbial metabolism in diverse environments 251.0 13.0 0.0 1.0 1.0 I 3.0 10.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 13.0 0.2307692307692307 0.7692307692307693 0.0119303113049228 0.0521660711922352 0.032048191248579 0.0402357598873124 0 0 0 0 K16881 0.1971428571428571 0.2165242165242165 K16881; mannose-1-phosphate guanylyltransferase / phosphomannomutase [EC:2.7.7.13 5.4.2.8] path:map00051,path:map00520,path:map01100,path:map01110 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 120.0 76.0 19.0 5.0 0.383838383838384 M 92.0 106.0 4.0 0.505050505050505 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 198.0 0.4646464646464646 0.5353535353535354 0.901450227449469 0.544972307951129 0.7232112677002991 0.3564779194983399 1 1 1 1 K16885 0.0342857142857142 0.0598290598290598 qmoA; quinone-modifying oxidoreductase, subunit QmoA 309.0 45.0 0.0 1.0 1.0 C 12.0 33.0 1.0 1.0 COG1148 Heterodisulfide_reductase,_subunit_A_(polyferredoxin) HdrA 45.0 0.2666666666666666 0.7333333333333333 0.0075553895140777 0.0128165645258467 0.0101859770199622 0.005261175011769 0 0 0 0 K16886 0.0428571428571428 0.0598290598290598 qmoB; quinone-modifying oxidoreductase, subunit QmoB 368.0 55.0 0.0 1.0 1.0 C 21.0 33.0 3.0 0.945454545454545 COG1148 Heterodisulfide_reductase,_subunit_A_(polyferredoxin) HdrA 54.0 0.3888888888888889 0.6111111111111112 0.0072586587403824 0.0459227203329994 0.0265906895366909 0.038664061592617 0 0 0 0 K16887 0.0485714285714285 0.0826210826210826 qmoC; quinone-modifying oxidoreductase, subunit QmoC 92.0 58.0 0.0 1.0 1.0 C 19.0 39.0 3.0 0.810344827586207 COG1150 Heterodisulfide_reductase,_subunit_C HdrC 58.0 0.3275862068965517 0.6724137931034483 0.249512396656257 0.787144629439647 0.518328513047952 0.53763223278339 0 0 0 0 K16898 0.1142857142857142 0.3903133903133903 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-] 229.0 195.0 0.0 1.0 1.0 L 44.0 151.0 4.0 0.794871794871795 COG1074 3-5_helicase_subunit_RecB_of_the_DNA_repair_enzyme_RecBCD_(exonuclease_V) RecB 195.0 0.2256410256410256 0.7743589743589744 0.024614966930114 0.218127972809002 0.121371469869558 0.193513005878888 0 0 0 0 K16899 0.0571428571428571 0.2991452991452991 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-] 99.0 116.0 114.0 2.0 0.983050847457627 L 21.0 107.0 6.0 0.53125 COG3857 ATP-dependent_helicase/DNAse_subunit_B AddB 128.0 0.1640625 0.8359375 0.0081146207734052 0.214856432825027 0.1114855267992161 0.2067418120516218 0 0 0 0 K16902 0.0028571428571428 0.0142450142450142 E1.5.1.45; FAD reductase [NAD(P)H] [EC:1.5.1.45] path:map00350,path:map00380,path:map00740,path:map01100,path:map01120 Tyrosine metabolism,Tryptophan metabolism,Riboflavin metabolism,Metabolic pathways,Microbial metabolism in diverse environments 171.0 6.0 0.0 1.0 1.0 S 1.0 5.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 6.0 0.1666666666666666 0.8333333333333334 0.0369758624057738 0.137892720617715 0.0874342915117444 0.1009168582119411 0 0 0 0 K16905 0.0171428571428571 0.0284900284900284 K16905; fluoroquinolone transport system permease protein path:map02010 ABC transporters 189.0 9.0 0.0 1.0 1.0 P 6.0 12.0 4.0 0.5 COG0474 Magnesium-transporting_ATPase_(P-type) MgtA 18.0 0.3333333333333333 0.6666666666666666 0.151691635057841 0.469975400495415 0.310833517776628 0.318283765437574 0 0 0 0 K16906 0.0257142857142857 0.0227920227920227 K16906; fluoroquinolone transport system permease protein path:map02010 ABC transporters 186.0 9.0 6.0 2.0 0.75 CP 10.0 10.0 4.0 0.45 COG1668 ABC-type_Na+_efflux_pump,_permease_component_NatB NatB 20.0 0.5 0.5 0.301418276465553 0.423890693364619 0.362654484915086 0.1224724168990659 0 0 0 0 K16907 0.0542857142857142 0.0341880341880341 K16907; fluoroquinolone transport system ATP-binding protein [EC:7.6.2.-] path:map02010 ABC transporters 219.0 36.0 28.0 2.0 0.818181818181818 V 29.0 15.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 44.0 0.6590909090909091 0.3409090909090909 0.0879081533962982 0.740970953907246 0.4144395536517721 0.6530628005109478 0 0 0 0 K16914 0.0 0.0028490028490028 RIOX1, NO66; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [EC:1.14.11.- 1.14.11.27] 311.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 KOG3706 1.0 0.0 1.0 0 0 0 0 K16915 0.0257142857142857 0.168091168091168 cbiL; nickel transport protein path:map02010 ABC transporters 32.0 37.0 7.0 3.0 0.528571428571429 P 10.0 77.0 9.0 0.241379310344828 COG5266 Uncharacterized_protein,_contains_GH25_family_domain 87.0 0.1149425287356321 0.8850574712643678 0.041038235098362 0.0900096775960353 0.0655239563471986 0.0489714424976733 0 0 0 0 K16917 0.0 0.0113960113960113 yydI; putative peptide transport system ATP-binding protein path:map02010 ABC transporters 330.0 4.0 0.0 1.0 1.0 V 0.0 4.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 4.0 0.0 1.0 0.098432649340535 0.23519716745188 0.1668149083962075 0.136764518111345 0 0 0 0 K16918 0.0 0.0142450142450142 ytrF; acetoin utilization transport system permease protein path:map02010 ABC transporters 316.0 5.0 0.0 1.0 1.0 V 0.0 5.0 1.0 1.0 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 5.0 0.0 1.0 0.0941628847926688 0.237547220201046 0.1658550524968574 0.1433843354083772 0 0 0 0 K16919 0.0028571428571428 0.0113960113960113 ytrC_D; acetoin utilization transport system permease protein path:map02010 ABC transporters 377.0 1.0 22.0 1.0 1.0 COG1277 ABC-type_transport_system_involved_in_multi-copper_enzyme_maturation,_permease_component NosY 23.0 0.0434782608695652 0.9565217391304348 0 0 0 0 K16920 0.0 0.0056980056980056 ytrE; acetoin utilization transport system ATP-binding protein path:map02010 ABC transporters 227.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 2.0 0.0 1.0 0 0 0 0 K16921 0.0 0.0056980056980056 ytrB; acetoin utilization transport system ATP-binding protein path:map02010 ABC transporters 289.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 2.0 0.0 1.0 0 0 0 0 K16922 0.02 0.1595441595441595 yydH; putative peptide zinc metalloprotease protein 39.0 67.0 52.0 6.0 0.650485436893204 M 10.0 91.0 11.0 0.368932038834951 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 101.0 0.099009900990099 0.900990099009901 0.114618404829159 0.63593712313379 0.3752777639814745 0.5213187183046311 0 0 0 0 K16923 0.0114285714285714 0.0655270655270655 qrtT; energy-coupling factor transport system substrate-specific component 133.0 20.0 17.0 3.0 0.769230769230769 T 6.0 27.0 6.0 0.545454545454545 COG3275 Sensor_histidine_kinase,_LytS/YehU_family LytS 33.0 0.1818181818181818 0.8181818181818182 0.0840587339142028 0.113378093839477 0.0987184138768399 0.0293193599252742 0 0 0 0 K16924 0.0285714285714285 0.1424501424501424 mtsT; energy-coupling factor transport system substrate-specific component 92.0 18.0 0.0 4.0 0.346153846153846 I 11.0 52.0 3.0 0.507936507936508 COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol_kinase IspE 63.0 0.1746031746031746 0.8253968253968254 0.124489410769841 0.886097740245309 0.505293575507575 0.761608329475468 0 0 0 0 K16925 0.0457142857142857 0.0883190883190883 ykoE; energy-coupling factor transport system permease protein 131.0 31.0 18.0 3.0 0.688888888888889 S 18.0 34.0 3.0 0.788461538461538 COG4721 ABC-type_thiamine/hydroxymethylpyrimidine_transport_system,_permease_component YkoE 52.0 0.3461538461538461 0.6538461538461539 0.0260174345974562 0.027704892560025 0.0268611635787406 0.0016874579625687 0 0 0 0 K16926 0.0085714285714285 0.0455840455840455 htsT; energy-coupling factor transport system substrate-specific component 169.0 24.0 0.0 1.0 1.0 S 3.0 21.0 6.0 0.583333333333333 2BY0N 24.0 0.125 0.875 0.0122599683923137 0.0348344257655208 0.0235471970789172 0.0225744573732071 0 0 0 0 K16927 0.1171428571428571 0.0883190883190883 cbrT; energy-coupling factor transport system substrate-specific component 97.0 56.0 40.0 5.0 0.717948717948718 S 45.0 33.0 5.0 0.615384615384615 COG4720 ECF-type_riboflavin_transporter,_membrane_(S)_component ECF-S 78.0 0.5769230769230769 0.4230769230769231 0.825598359708183 0.967853196199004 0.8967257779535935 0.142254836490821 1 1 1 1 K16928 0.0371428571428571 0.0398860398860398 mtaT; energy-coupling factor transport system substrate-specific component 130.0 13.0 10.0 4.0 0.68421052631579 EG 15.0 15.0 5.0 0.366666666666667 arCOG09422 30.0 0.5 0.5 0.015794846534482 0.0657176259678758 0.0407562362511789 0.0499227794333937 0 0 0 0 K16929 0.0 0.0085470085470085 K16929; energy-coupling factor transport system substrate-specific component 160.0 1.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 2AVQT 3.0 0.0 1.0 0 0 0 0 K16933 0.0428571428571428 0.0 doxB; heme bearing subunit I of the terminal oxidase 439.0 34.0 0.0 1.0 1.0 C 34.0 0.0 1.0 1.0 COG0843 Heme/copper-type_cytochrome/quinol_oxidase,_subunit_1 CyoB 34.0 1.0 0.0 0.0034408834127171 0.005290037864471 0.004365460638594 0.0018491544517539 0 0 0 0 K16934 0.0228571428571428 0.0 doxC; terminal oxidase subunit 328.0 8.0 0.0 1.0 1.0 arCOG05891 8.0 1.0 0.0 0 0 0 0 K16935 0.02 0.0 doxE; terminal oxidase small hydrophobic subunit 62.0 7.0 0.0 1.0 1.0 arCOG05892 7.0 1.0 0.0 0 0 0 0 K16936 0.0257142857142857 0.0284900284900284 doxA; thiosulfate dehydrogenase (quinone) small subunit [EC:1.8.5.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 134.0 22.0 0.0 1.0 1.0 S 12.0 10.0 2.0 0.545454545454545 arCOG05342 22.0 0.5454545454545454 0.4545454545454545 0.142677010266272 0.478918995729703 0.3107980029979875 0.336241985463431 0 0 0 0 K16937 0.2057142857142857 0.1994301994301994 doxD; thiosulfate dehydrogenase (quinone) large subunit [EC:1.8.5.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 69.0 213.0 202.0 2.0 0.950892857142857 S 138.0 89.0 11.0 0.704845814977974 COG2259 Uncharacterized_membrane_protein_YphA,_DoxX/SURF4_family DoxX 227.0 0.6079295154185022 0.3920704845814978 0.0143276754777372 0.863319898966628 0.4388237872221825 0.8489922234888908 0 0 0 0 K16950 0.0542857142857142 0.0883190883190883 asrA; anaerobic sulfite reductase subunit A path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 164.0 46.0 39.0 2.0 0.867924528301887 C 19.0 34.0 4.0 0.452830188679245 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 53.0 0.3584905660377358 0.6415094339622641 0.348418010827933 0.920316133240559 0.634367072034246 0.571898122412626 0 0 0 0 K16951 0.0657142857142857 0.0997150997150997 asrB; anaerobic sulfite reductase subunit B path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 202.0 55.0 44.0 2.0 0.833333333333333 C 24.0 42.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 66.0 0.3636363636363636 0.6363636363636364 0.250622282136372 0.478493393980403 0.3645578380583875 0.227871111844031 0 0 0 0 K16952 0.0142857142857142 0.0028490028490028 sor; sulfur oxygenase/reductase [EC:1.13.11.55] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 286.0 7.0 0.0 1.0 1.0 S 5.0 2.0 2.0 0.857142857142857 arCOG06967 7.0 0.7142857142857143 0.2857142857142857 0.0072755102255234 0.0157127563844805 0.0114941333050019 0.0084372461589571 0 0 0 0 K16953 0.0 0.0142450142450142 dddL; dimethylpropiothetin dethiomethylase [EC:4.4.1.3] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 168.0 4.0 2.0 2.0 0.666666666666667 G 0.0 6.0 2.0 0.666666666666667 COG0662 Mannose-6-phosphate_isomerase,_cupin_superfamily ManC 6.0 0.0 1.0 0.0258796792408591 0.0505010805995522 0.0381903799202056 0.0246214013586931 0 0 0 0 K16954 0.0285714285714285 0.0 mtsA; methylthiol:coenzyme M methyltransferase [EC:2.1.1.251] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 323.0 15.0 0.0 1.0 1.0 H 15.0 0.0 1.0 1.0 COG0407 Uroporphyrinogen-III_decarboxylase_HemE HemE 15.0 1.0 0.0 0.0103603552377359 0.0363261891319046 0.0233432721848202 0.0259658338941686 0 0 0 0 K16955 0.0428571428571428 0.0 mtsB; methylated-thiol--corrinoid protein path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 242.0 11.0 3.0 2.0 0.578947368421053 T 19.0 0.0 1.0 1.0 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 19.0 1.0 0.0 0.0020076835437084 0.0040912152676946 0.0030494494057015 0.0020835317239861 0 0 0 0 K16956 0.0 0.0028490028490028 tcyJ; L-cystine transport system substrate-binding protein path:map02010 ABC transporters 262.0 1.0 0.0 1.0 1.0 ET 0.0 1.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 1.0 0.0 1.0 0 0 0 0 K16957 0.0 0.017094017094017 tcyK; L-cystine transport system substrate-binding protein path:map02010 ABC transporters 251.0 10.0 0.0 1.0 1.0 ET 0.0 10.0 1.0 1.0 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 10.0 0.0 1.0 0.0090839782728211 0.151613679189151 0.080348828730986 0.1425297009163299 0 0 0 0 K16958 0.0 0.0142450142450142 tcyL; L-cystine transport system permease protein path:map02010 ABC transporters 228.0 2.0 0.0 3.0 0.4 E 0.0 5.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 5.0 0.0 1.0 0.0149020389966568 0.0483985253550434 0.0316502821758501 0.0334964863583866 0 0 0 0 K16959 0.0 0.0256410256410256 tcyM; L-cystine transport system permease protein path:map02010 ABC transporters 222.0 7.0 4.0 3.0 0.636363636363636 P 0.0 11.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 11.0 0.0 1.0 0.115742544451397 0.33624970843406 0.2259961264427284 0.2205071639826629 0 0 0 0 K16960 0.0 0.0455840455840455 tcyN; L-cystine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 243.0 19.0 0.0 1.0 1.0 E 0.0 19.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 19.0 0.0 1.0 0.0410795893078728 0.0605889965206835 0.0508342929142781 0.0195094072128107 0 0 0 0 K16961 0.0 0.0199430199430199 yxeM; putative S-methylcysteine transport system substrate-binding protein path:map02010 ABC transporters 175.0 9.0 7.0 3.0 0.75 ET 0.0 12.0 2.0 0.75 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 12.0 0.0 1.0 0.0128623498686538 0.0607656431936009 0.0368139965311273 0.0479032933249471 0 0 0 0 K16962 0.0 0.0398860398860398 yxeN; putative S-methylcysteine transport system permease protein path:map02010 ABC transporters 215.0 9.0 3.0 3.0 0.5625 P 0.0 16.0 1.0 1.0 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 16.0 0.0 1.0 0.0499263738784671 0.0986470615081068 0.0742867176932869 0.0487206876296397 0 0 0 0 K16963 0.0 0.0313390313390313 yxeO; putative S-methylcysteine transport system ATP-binding protein path:map02010 ABC transporters 185.0 16.0 0.0 1.0 1.0 E 0.0 16.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 16.0 0.0 1.0 0.011551304037769 0.0238018185976147 0.0176765613176918 0.0122505145598457 0 0 0 0 K16964 0.0 0.0085470085470085 ddhA; dimethylsulfide dehydrogenase subunit alpha [EC:1.8.2.4] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 1125.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 7.0 0.0 1.0 0.0098776830372994 0.0183635842561606 0.01412063364673 0.0084859012188611 0 0 0 0 K16965 0.0028571428571428 0.017094017094017 ddhB; dimethylsulfide dehydrogenase subunit beta path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 410.0 11.0 0.0 1.0 1.0 C 1.0 10.0 1.0 1.0 COG1140 Nitrate_reductase_beta_subunit NarY 11.0 0.0909090909090909 0.9090909090909092 0.0349812410565826 0.0374648510874799 0.0362230460720312 0.0024836100308972 0 0 0 0 K16968 0.0 0.0256410256410256 msmA; methanesulfonate monooxygenase subunit alpha [EC:1.14.13.111] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 395.0 7.0 4.0 3.0 0.538461538461538 P 0.0 13.0 2.0 0.923076923076923 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 13.0 0.0 1.0 0.0042602564354643 0.0072945836416202 0.0057774200385422 0.0030343272061559 0 0 0 0 K16969 0.0 0.0028490028490028 msmB; methanesulfonate monooxygenase subunit beta [EC:1.14.13.111] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 162.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K17047 0.0085714285714285 0.0 RAB19; Ras-related protein Rab-19 171.0 4.0 3.0 2.0 0.8 U 5.0 0.0 1.0 1.0 KOG0084 5.0 1.0 0.0 0.0082609012258042 0.0115834240026974 0.0099221626142508 0.0033225227768932 0 0 0 0 K17048 0.0028571428571428 0.0199430199430199 ebdB; ethylbenzene hydroxylase subunit beta path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 381.0 12.0 0.0 1.0 1.0 C 1.0 11.0 1.0 1.0 COG1140 Nitrate_reductase_beta_subunit NarY 12.0 0.0833333333333333 0.9166666666666666 0.0405092687954641 0.0522060381116537 0.0463576534535589 0.0116967693161896 0 0 0 0 K17050 0.0485714285714285 0.037037037037037 serA, clrA; selenate/chlorate reductase subunit alpha [EC:1.97.1.9 1.97.1.1] path:map00450 Selenocompound metabolism 767.0 36.0 0.0 1.0 1.0 C 19.0 17.0 2.0 0.583333333333333 COG5013 Nitrate_reductase_alpha_subunit NarG 36.0 0.5277777777777778 0.4722222222222222 0.141928977729101 0.622152958545254 0.3820409681371775 0.480223980816153 0 0 0 0 K17051 0.0457142857142857 0.0484330484330484 serB, clrB; selenate/chlorate reductase subunit beta [EC:1.97.1.9 1.97.1.1] path:map00450 Selenocompound metabolism 275.0 38.0 0.0 1.0 1.0 C 16.0 22.0 1.0 1.0 COG1140 Nitrate_reductase_beta_subunit NarY 38.0 0.4210526315789473 0.5789473684210527 0.0620441464228479 0.200737829111843 0.1313909877673454 0.1386936826889951 0 0 0 0 K17052 0.0457142857142857 0.0427350427350427 serC, clrC; selenate/chlorate reductase subunit gamma [EC:1.97.1.9 1.97.1.1] path:map00450 Selenocompound metabolism 124.0 27.0 17.0 3.0 0.710526315789474 C 16.0 22.0 3.0 0.473684210526316 COG2180 Nitrate_reductase_assembly_protein_NarJ,_required_for_insertion_of_molybdenum_cofactor NarJ 38.0 0.4210526315789473 0.5789473684210527 0.125320326559672 0.380843524715128 0.2530819256374 0.255523198155456 0 0 0 0 K17062 0.0 0.0142450142450142 bgtB; arginine/lysine/histidine/glutamine transport system substrate-binding and permease protein path:map02010 ABC transporters 440.0 4.0 2.0 2.0 0.666666666666667 P 0.0 6.0 2.0 0.833333333333333 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 6.0 0.0 1.0 0.0445047834885866 0.110911218829043 0.0777080011588148 0.0664064353404564 0 0 0 0 K17063 0.0 0.0142450142450142 bgtA; arginine/lysine/histidine/glutamine transport system ATP-binding protein [EC:7.4.2.1] path:map02010 ABC transporters 246.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 6.0 0.0 1.0 9.33760326514193e-06 0.0455503472643976 0.0227798424338313 0.0455410096611324 0 0 0 0 K17064 0.0657142857142857 0.0 ddh; D-2-hydroxyacid dehydrogenase (NADP+) [EC:1.1.1.272] 305.0 30.0 0.0 1.0 1.0 H 30.0 0.0 1.0 1.0 COG0111 Phosphoglycerate_dehydrogenase_or_related_dehydrogenase SerA 30.0 1.0 0.0 0.0072162747300748 0.0192867573832998 0.0132515160566873 0.0120704826532249 0 0 0 0 K17067 0.0 0.0085470085470085 mdo; formaldehyde dismutase / methanol dehydrogenase [EC:1.2.98.1 1.1.99.37] path:map00625,path:map00680,path:map01100,path:map01120,path:map01200 Chloroalkane and chloroalkene degradation,Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 418.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 3.0 0.0 1.0 0 0 0 0 K17069 0.0 0.0028490028490028 MET17; O-acetylhomoserine/O-acetylserine sulfhydrylase [EC:2.5.1.49 2.5.1.47] path:map00270,path:map00920,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 429.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 1.0 0.0 1.0 0 0 0 0 K17070 0.0 0.0056980056980056 dcmA; dichloromethane dehalogenase [EC:4.5.1.3] path:map00625,path:map01120 Chloroalkane and chloroalkene degradation,Microbial metabolism in diverse environments 106.0 2.0 0.0 1.0 1.0 O 0.0 2.0 1.0 1.0 COG0625 Glutathione_S-transferase GstA 2.0 0.0 1.0 0 0 0 0 K17071 0.0 0.0085470085470085 dcmR; transcriptional repressor of dcmA and dcmR 229.0 2.0 1.0 2.0 0.666666666666667 L 0.0 3.0 1.0 1.0 COG0467 RecA-superfamily_ATPase,_KaiC/GvpD/RAD55_family RAD55 3.0 0.0 1.0 0 0 0 0 K17073 0.0 0.0797720797720797 lysX1; putative lysine transport system substrate-binding protein path:map02010 ABC transporters 211.0 19.0 6.0 3.0 0.527777777777778 ET 0.0 30.0 2.0 0.527777777777778 COG0834 ABC-type_amino_acid_transport/signal_transduction_system,_periplasmic_component/domain HisJ 30.0 0.0 1.0 0.0119770754011272 0.0810583672688196 0.0465177213349734 0.0690812918676924 0 0 0 0 K17074 0.0 0.0626780626780626 lysX2; putative lysine transport system permease protein path:map02010 ABC transporters 138.0 17.0 4.0 4.0 0.5 P 0.0 34.0 4.0 0.617647058823529 COG0765 ABC-type_amino_acid_transport_system,_permease_component HisM 34.0 0.0 1.0 0.104407978137506 0.0346567715782841 0.069532374857895 0.0697512065592219 0 0 0 0 K17076 0.0085714285714285 0.0997150997150997 lysY; putative lysine transport system ATP-binding protein path:map02010 ABC transporters 229.0 37.0 34.0 3.0 0.880952380952381 E 3.0 39.0 2.0 0.880952380952381 COG1126 ABC-type_polar_amino_acid_transport_system,_ATPase_component GlnQ 42.0 0.0714285714285714 0.9285714285714286 0.329932828238426 0.586965010760619 0.4584489194995225 0.257032182522193 0 0 0 0 K17081 0.0028571428571428 0.0 PHB2; prohibitin 2 270.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1798 Diphthamide_biosynthesis_methyltransferase DPH5 1.0 1.0 0.0 0 0 0 0 K17103 0.3057142857142857 0.5213675213675214 CHO1, pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] path:map00260,path:map00564,path:map01100,path:map01110 Glycine, serine and threonine metabolism,Glycerophospholipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 76.0 307.0 305.0 2.0 0.993527508090615 I 116.0 193.0 2.0 0.983818770226537 COG1183 Phosphatidylserine_synthase PssA 309.0 0.3754045307443365 0.6245954692556634 0.0208241092941888 0.237226773422078 0.1290254413581334 0.2164026641278892 0 0 0 0 K17104 0.7085714285714285 0.0 E2.5.1.41; phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 148.0 245.0 218.0 2.0 0.900735294117647 H 272.0 0.0 1.0 1.0 COG1646 Glycerol-1-phosphate_heptaprenyltransferase PcrB 272.0 1.0 0.0 0.0093694125702981 0.843295257849792 0.426332335210045 0.8339258452794939 0 0 0 0 K17105 0.7114285714285714 0.0683760683760683 E2.5.1.42; geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 113.0 234.0 145.0 2.0 0.724458204334365 H 298.0 25.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 323.0 0.9226006191950464 0.0773993808049535 0.3740479934117 0.84858387701741 0.611315935214555 0.47453588360571 0 0 0 0 K17108 0.0057142857142857 0.074074074074074 GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45] path:map00511,path:map00600,path:map01100 Other glycan degradation,Sphingolipid metabolism,Metabolic pathways 513.0 31.0 0.0 1.0 1.0 G 2.0 29.0 2.0 0.935483870967742 COG4354 Uncharacterized_conserved_protein,_contains_GBA2_N_and_DUF608_domains 31.0 0.064516129032258 0.935483870967742 0.0214659431335811 0.162615174939336 0.0920405590364585 0.1411492318057549 0 0 0 0 K17195 0.0 0.0142450142450142 alsE; D-allulose-6-phosphate 3-epimerase [EC:5.1.3.-] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 212.0 6.0 0.0 1.0 1.0 G 0.0 6.0 1.0 1.0 COG0036 Pentose-5-phosphate-3-epimerase Rpe 6.0 0.0 1.0 0.420946010844643 0.176720146537788 0.2988330786912155 0.244225864306855 0 0 0 0 K17199 0.0114285714285714 0.0 RASEF, RAB45; Ras and EF-hand domain-containing protein 162.0 3.0 1.0 2.0 0.6 TU 5.0 0.0 1.0 1.0 KOG0078 5.0 1.0 0.0 0.50079045832346 0.0218451823400359 0.2613178203317479 0.4789452759834241 0 0 0 1 K17200 0.0028571428571428 0.0 ARL14, ARF7; ADP-ribosylation factor-like protein 14 173.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 COG1100 GTPase_SAR1_family_domain Gem1 1.0 1.0 0.0 0 0 0 0 K17202 0.0 0.0484330484330484 eryG; erythritol transport system substrate-binding protein path:map02010 ABC transporters 280.0 19.0 0.0 1.0 1.0 G 0.0 19.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 19.0 0.0 1.0 0.309993359575067 0.232480605908862 0.2712369827419645 0.077512753666205 0 0 0 0 K17203 0.0 0.0455840455840455 eryF; erythritol transport system permease protein path:map02010 ABC transporters 314.0 18.0 17.0 3.0 0.9 G 0.0 20.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 20.0 0.0 1.0 0.121748732401023 0.167998256080431 0.144873494240727 0.046249523679408 0 0 0 0 K17204 0.0 0.0427350427350427 eryE; erythritol transport system ATP-binding protein path:map02010 ABC transporters 470.0 16.0 15.0 2.0 0.941176470588235 G 0.0 17.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 17.0 0.0 1.0 0.100899697674712 0.161717901030332 0.131308799352522 0.06081820335562 0 0 0 0 K17205 0.0 0.0256410256410256 xltC; putative xylitol transport system substrate-binding protein path:map02010 ABC transporters 295.0 10.0 0.0 1.0 1.0 G 0.0 10.0 1.0 1.0 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 10.0 0.0 1.0 0.0298370583991765 0.0768103776859988 0.0533237180425876 0.0469733192868223 0 0 0 0 K17206 0.0057142857142857 0.0256410256410256 xltB; putative xylitol transport system permease protein path:map02010 ABC transporters 305.0 10.0 9.0 2.0 0.909090909090909 G 2.0 9.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 11.0 0.1818181818181818 0.8181818181818182 0.0616520160082718 0.183073536057595 0.1223627760329334 0.1214215200493231 0 0 0 0 K17207 0.0 0.0085470085470085 xltA; putative xylitol transport system ATP-binding protein path:map02010 ABC transporters 487.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 3.0 0.0 1.0 0 0 0 0 K17209 0.0 0.0313390313390313 iatP; inositol transport system permease protein path:map02010 ABC transporters 300.0 13.0 0.0 1.0 1.0 G 0.0 13.0 1.0 1.0 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 13.0 0.0 1.0 0.0390573435066379 0.0723091625288104 0.0556832530177241 0.0332518190221724 0 0 0 0 K17210 0.0 0.0199430199430199 iatA; inositol transport system ATP-binding protein path:map02010 ABC transporters 478.0 10.0 0.0 1.0 1.0 G 0.0 10.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 10.0 0.0 1.0 4.73162469366428e-12 0.0001081654272508 5.4082715991212345e-05 0.0001081654225191 0 0 0 0 K17213 0.0 0.0797720797720797 K17213; inositol transport system substrate-binding protein path:map02010 ABC transporters 255.0 42.0 0.0 1.0 1.0 G 0.0 43.0 2.0 0.976744186046512 COG1879 ABC-type_sugar_transport_system,_periplasmic_component,_contains_N-terminal_xre_family_HTH_domain RbsB 43.0 0.0 1.0 0.0247519293083021 0.596569504835109 0.3106607170717055 0.5718175755268069 0 0 0 0 K17214 0.0028571428571428 0.0455840455840455 K17214; inositol transport system permease protein path:map02010 ABC transporters 296.0 16.0 13.0 2.0 0.842105263157895 G 1.0 18.0 2.0 0.947368421052632 COG1172 Ribose/xylose/arabinose/galactoside_ABC-type_transport_system,_permease_component AraH 19.0 0.0526315789473684 0.9473684210526316 0.0938599414202834 0.165868479901681 0.1298642106609822 0.0720085384813976 0 0 0 0 K17215 0.0028571428571428 0.0341880341880341 K17215; inositol transport system ATP-binding protein path:map02010 ABC transporters 458.0 14.0 9.0 2.0 0.736842105263158 G 1.0 18.0 1.0 1.0 COG1129 ABC-type_sugar_transport_system,_ATPase_component MglA 19.0 0.0526315789473684 0.9473684210526316 0.0235934991836742 0.0640426066208065 0.0438180529022403 0.0404491074371323 0 0 0 0 K17216 0.0 0.0313390313390313 mccA; cystathionine beta-synthase (O-acetyl-L-serine) [EC:2.5.1.134] path:map00270,path:map01100,path:map01230 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids 293.0 9.0 7.0 2.0 0.818181818181818 E 0.0 11.0 2.0 0.818181818181818 COG0031 Cysteine_synthase CysK 11.0 0.0 1.0 0.0181942447829679 0.0569725634488262 0.037583404115897 0.0387783186658583 0 0 0 0 K17217 0.0028571428571428 0.0427350427350427 mccB; cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2] path:map00260,path:map00270,path:map00920,path:map01100,path:map01110,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids 377.0 16.0 0.0 1.0 1.0 E 1.0 15.0 1.0 1.0 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 16.0 0.0625 0.9375 0.0065251884635216 0.0181508488279813 0.0123380186457514 0.0116256603644596 0 0 0 0 K17218 0.2685714285714285 0.2735042735042735 sqr; sulfide:quinone oxidoreductase [EC:1.8.5.4] path:map00920,path:map01120 Sulfur metabolism,Microbial metabolism in diverse environments 127.0 296.0 271.0 4.0 0.888888888888889 S 183.0 149.0 4.0 0.981981981981982 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 332.0 0.5512048192771084 0.4487951807228915 0.32839178147359 0.873299809591183 0.6008457955323865 0.5449080281175931 0 0 0 0 K17219 0.0114285714285714 0.0 sreA; sulfur reductase molybdopterin subunit path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 866.0 5.0 0.0 1.0 1.0 C 5.0 0.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 5.0 1.0 0.0 0.0184081369989989 0.0315358819565193 0.0249720094777591 0.0131277449575204 0 0 0 0 K17220 0.0142857142857142 0.0 sreB; sulfur reductase FeS subunit path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 188.0 5.0 0.0 1.0 1.0 C 5.0 0.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 5.0 1.0 0.0 0.068780039801172 0.119211972362219 0.0939960060816955 0.050431932561047 0 0 0 0 K17221 0.0257142857142857 0.0 sreC; sulfur reductase membrane anchor path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 270.0 11.0 0.0 1.0 1.0 C 11.0 0.0 1.0 1.0 arCOG02026 11.0 1.0 0.0 0.0249825851878323 0.127231174613635 0.0761068799007336 0.1022485894258027 0 0 0 0 K17222 0.0 0.1025641025641025 soxA; L-cysteine S-thiosulfotransferase [EC:2.8.5.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 157.0 41.0 0.0 1.0 1.0 C 0.0 41.0 3.0 0.878048780487805 COG3258 Thiosulfate_dehydrogenase_TsdA,_contains_C-terminal_cytochrome_c_domain TsdA 41.0 0.0 1.0 0.0400249158443802 0.135823267688446 0.0879240917664131 0.0957983518440658 0 0 0 0 K17223 0.0 0.1225071225071225 soxX; L-cysteine S-thiosulfotransferase [EC:2.8.5.2] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 71.0 48.0 0.0 1.0 1.0 C 0.0 48.0 3.0 0.833333333333333 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 48.0 0.0 1.0 0.0064243756001192 0.136668921538448 0.0715466485692836 0.1302445459383288 0 0 0 0 K17224 0.0 0.1082621082621082 soxB; S-sulfosulfanyl-L-cysteine sulfohydrolase [EC:3.1.6.20] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 421.0 41.0 0.0 1.0 1.0 F 0.0 41.0 1.0 1.0 COG0737 2',3'-cyclic-nucleotide_2'-phosphodiesterase/5'-_or_3'-nucleotidase,_5'-nucleotidase_family UshA 41.0 0.0 1.0 0.0502473667703293 0.113734022630872 0.0819906947006006 0.0634866558605427 0 0 0 0 K17225 0.0 0.074074074074074 soxC; sulfane dehydrogenase subunit SoxC path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 359.0 27.0 26.0 3.0 0.931034482758621 S 0.0 29.0 1.0 1.0 COG2041 Molybdopterin-dependent_catalytic_subunit_of_periplasmic_DMSO/TMAO_and_protein-methionine-sulfoxide_reductases MsrP 29.0 0.0 1.0 0.0040523458799734 0.0080227529713743 0.0060375494256738 0.0039704070914008 0 0 0 0 K17226 0.0 0.1082621082621082 soxY; sulfur-oxidizing protein SoxY path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 90.0 62.0 0.0 1.0 1.0 S 0.0 64.0 1.0 1.0 COG5501 Sulfur_oxidation_protein_SoxY SoxY 64.0 0.0 1.0 0.0035989719476847 0.0080251707925354 0.00581207137011 0.0044261988448507 0 0 0 0 K17227 0.0 0.1025641025641025 soxZ; sulfur-oxidizing protein SoxZ path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 92.0 30.0 17.0 2.0 0.697674418604651 S 0.0 45.0 3.0 0.688888888888889 COG5501 Sulfur_oxidation_protein_SoxY SoxY 45.0 0.0 1.0 0.0084009369306975 0.0185999835555872 0.0135004602431423 0.0101990466248897 0 0 0 0 K17228 0.0628571428571428 0.0398860398860398 sfnG; dimethylsulfone monooxygenase [EC:1.14.14.35] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 228.0 45.0 0.0 1.0 1.0 C 26.0 19.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 45.0 0.5777777777777777 0.4222222222222222 0.192139734065244 0.459166002089864 0.325652868077554 0.26702626802462 0 0 0 0 K17229 0.0 0.0626780626780626 fccB; sulfide dehydrogenase [flavocytochrome c] flavoprotein chain [EC:1.8.2.3] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 394.0 25.0 20.0 2.0 0.833333333333333 S 0.0 30.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 30.0 0.0 1.0 0.0034304628015522 0.0068929457882324 0.0051617042948922 0.0034624829866801 0 0 0 0 K17230 0.0 0.0341880341880341 fccA; cytochrome subunit of sulfide dehydrogenase path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 86.0 19.0 0.0 1.0 1.0 C 0.0 19.0 1.0 1.0 COG2863 Cytochrome_c553 CytC553 19.0 0.0 1.0 0.0092464525090779 0.0163098371730135 0.0127781448410457 0.0070633846639356 0 0 0 0 K17234 0.0 0.0227920227920227 araN; arabinooligosaccharide transport system substrate-binding protein path:map02010 ABC transporters 407.0 8.0 0.0 1.0 1.0 G 0.0 8.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 8.0 0.0 1.0 0.0489346094755268 0.110377193517779 0.0796559014966529 0.0614425840422521 0 0 0 0 K17235 0.0028571428571428 0.037037037037037 araP; arabinooligosaccharide transport system permease protein path:map02010 ABC transporters 227.0 33.0 28.0 3.0 0.825 P 1.0 39.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 40.0 0.025 0.975 0.001566862945062 0.0031078893257978 0.0023373761354299 0.0015410263807358 0 0 0 0 K17236 0.0 0.0227920227920227 araQ; arabinooligosaccharide transport system permease protein path:map02010 ABC transporters 258.0 4.0 1.0 3.0 0.5 G 0.0 8.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 8.0 0.0 1.0 0.0555674466606794 0.424274420692523 0.2399209336766012 0.3687069740318436 0 0 0 0 K17237 0.04 0.0313390313390313 inoE; inositol-phosphate transport system substrate-binding protein path:map02010 ABC transporters 387.0 18.0 11.0 2.0 0.72 G 14.0 11.0 1.0 1.0 COG2182 Maltose-binding_periplasmic_protein_MalE MalE 25.0 0.56 0.44 0.110025752342792 0.107705317361068 0.10886553485193 0.0023204349817239 0 0 0 0 K17238 0.0457142857142857 0.0199430199430199 inoF; inositol-phosphate transport system permease protein path:map02010 ABC transporters 261.0 23.0 22.0 2.0 0.958333333333333 P 16.0 8.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 24.0 0.6666666666666666 0.3333333333333333 0.0527548629397397 0.0845733810118142 0.0686641219757769 0.0318185180720745 0 0 0 0 K17239 0.0457142857142857 0.017094017094017 inoG; inositol-phosphate transport system permease protein path:map02010 ABC transporters 252.0 23.0 22.0 2.0 0.958333333333333 P 18.0 6.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 24.0 0.75 0.25 0.0729441105647663 0.204311525046739 0.1386278178057526 0.1313674144819727 0 0 0 0 K17240 0.0885714285714285 0.0256410256410256 inoK; inositol-phosphate transport system ATP-binding protein path:map02010 ABC transporters 292.0 40.0 31.0 3.0 0.714285714285714 E 47.0 9.0 2.0 0.839285714285714 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 56.0 0.8392857142857143 0.1607142857142857 0.982625083073394 0.950237762332604 0.9664314227029992 0.0323873207407899 1 1 1 1 K17241 0.0 0.0199430199430199 aguE; alpha-1,4-digalacturonate transport system substrate-binding protein path:map02010 ABC transporters 380.0 8.0 0.0 1.0 1.0 G 0.0 8.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 8.0 0.0 1.0 0.195312705510742 0.286614042226173 0.2409633738684575 0.0913013367154309 0 0 0 0 K17242 0.0 0.0484330484330484 aguF; alpha-1,4-digalacturonate transport system permease protein path:map02010 ABC transporters 226.0 53.0 50.0 3.0 0.929824561403509 P 0.0 57.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 57.0 0.0 1.0 0.0041327754204716 0.00720183158679 0.0056673035036308 0.0030690561663183 0 0 0 0 K17243 0.0 0.0541310541310541 aguG; alpha-1,4-digalacturonate transport system permease protein path:map02010 ABC transporters 252.0 14.0 7.0 2.0 0.666666666666667 P 0.0 21.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 21.0 0.0 1.0 0.495848845760363 0.812695610074576 0.6542722279174695 0.316846764314213 0 0 0 0 K17244 0.0 0.0769230769230769 chiE; putative chitobiose transport system substrate-binding protein path:map02010 ABC transporters 345.0 34.0 0.0 1.0 1.0 G 0.0 34.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 34.0 0.0 1.0 0.469850230621937 0.829297126837003 0.6495736787294699 0.359446896215066 0 0 0 0 K17245 0.0085714285714285 0.0826210826210826 chiF; putative chitobiose transport system permease protein path:map02010 ABC transporters 229.0 29.0 13.0 3.0 0.591836734693878 P 3.0 46.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 49.0 0.0612244897959183 0.9387755102040816 0.0268236825783142 0.0340314443758661 0.0304275634770901 0.0072077617975519 0 0 0 0 K17246 0.0 0.0626780626780626 chiG; putative chitobiose transport system permease protein path:map02010 ABC transporters 260.0 13.0 4.0 3.0 0.52 G 0.0 25.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 25.0 0.0 1.0 0.278351520740399 0.840488453459853 0.559419987100126 0.5621369327194541 0 0 0 0 K17247 0.06 0.1595441595441595 msrQ; methionine sulfoxide reductase heme-binding subunit 109.0 73.0 69.0 2.0 0.948051948051948 C 22.0 62.0 5.0 0.761363636363636 COG2717 Heme-binding_membrane_subunit_of_periplasmic_DMSO/TMAO_and_protein-methionine-sulfoxide_reductases MsrQ 84.0 0.2619047619047619 0.7380952380952381 0.351238111261738 0.594581635517082 0.47290987338941 0.243343524255344 0 0 0 0 K17248 0.0085714285714285 0.0313390313390313 pglJ; N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.291] 281.0 15.0 0.0 1.0 1.0 M 3.0 12.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 15.0 0.2 0.8 0.0478048203367065 0.0702186898101413 0.0590117550734239 0.0224138694734348 0 0 0 0 K17249 0.0 0.0056980056980056 pglH; GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase [EC:2.4.1.292] 350.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 2.0 0.0 1.0 0 0 0 0 K17250 0.0028571428571428 0.0056980056980056 pglI; GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase [EC:2.4.1.293] 251.0 2.0 0.0 2.0 0.5 M 1.0 3.0 3.0 0.5 COG1216 Glycosyltransferase,_GT2_family WcaE 4.0 0.25 0.75 0.0455611537133568 8.80668987551528e-12 0.0227805768610817 0.0455611537045501 0 0 0 0 K17251 0.0 0.0113960113960113 pglB; undecaprenyl-diphosphooligosaccharide---protein glycotransferase [EC:2.4.99.19] 531.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG1287 Asparagine_N-glycosylation_enzyme,_membrane_subunit_Stt3 Stt3 4.0 0.0 1.0 0.0107191686597453 0.0251370885063175 0.0179281285830314 0.0144179198465722 0 0 0 0 K17266 0.0028571428571428 0.0085470085470085 MVP; major vault protein 371.0 4.0 3.0 2.0 0.8 O 1.0 4.0 2.0 0.8 COG0330 Regulator_of_protease_activity_HflC,_stomatin/prohibitin_superfamily HflC 5.0 0.2 0.8 7.81439209358391e-12 1.4693592050677898e-11 1.1253992072130904e-11 6.879199957093988e-12 0 0 0 0 K17277 0.0085714285714285 0.0 EPS8; epidermal growth factor receptor kinase substrate 8 322.0 3.0 0.0 1.0 1.0 T 3.0 0.0 1.0 1.0 COG3177 Fic_family_protein 3.0 1.0 0.0 0 0 0 0 K17283 0.0028571428571428 0.0 LTF; lactotransferrin [EC:3.4.21.-] 711.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 28KI0 1.0 1.0 0.0 0 0 0 0 K17285 0.0457142857142857 0.0769230769230769 SELENBP1; methanethiol oxidase [EC:1.8.3.4] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 360.0 40.0 31.0 2.0 0.816326530612245 S 19.0 30.0 2.0 0.612244897959184 COG3391 DNA-binding_beta-propeller_fold_protein_YncE YncE 49.0 0.3877551020408163 0.6122448979591837 0.0811445204877198 0.620176346234828 0.3506604333612739 0.5390318257471082 0 0 0 0 K17286 0.0057142857142857 0.0 STOM; erythrocyte band 7 integral membrane protein 290.0 2.0 0.0 1.0 1.0 C 2.0 0.0 1.0 1.0 COG0330 Regulator_of_protease_activity_HflC,_stomatin/prohibitin_superfamily HflC 2.0 1.0 0.0 0 0 0 0 K17299 0.0028571428571428 0.0 POTE; POTE ankyrin domain family protein 853.0 1.0 0.0 1.0 1.0 Z 1.0 0.0 1.0 1.0 COG5277 Actin-related_protein 1.0 1.0 0.0 0 0 0 0 K17311 0.0542857142857142 0.0142450142450142 treS; trehalose transport system substrate-binding protein path:map02010 ABC transporters 313.0 26.0 0.0 1.0 1.0 G 21.0 5.0 2.0 0.923076923076923 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 26.0 0.8076923076923077 0.1923076923076923 0.200247471245998 0.220817678187355 0.2105325747166765 0.020570206941357 0 0 0 0 K17312 0.0457142857142857 0.0142450142450142 treT; trehalose transport system permease protein path:map02010 ABC transporters 253.0 21.0 0.0 1.0 1.0 P 16.0 5.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 21.0 0.7619047619047619 0.238095238095238 0.0221470937746359 0.111114499419924 0.0666307965972799 0.0889674056452881 0 0 0 0 K17313 0.0428571428571428 0.0085470085470085 treU; trehalose transport system permease protein path:map02010 ABC transporters 259.0 17.0 16.0 2.0 0.944444444444444 P 15.0 3.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 18.0 0.8333333333333334 0.1666666666666666 0.0173968400648548 0.043490475961632 0.0304436580132433 0.0260936358967771 0 0 0 0 K17314 0.0485714285714285 0.0 treV; trehalose transport system ATP-binding protein path:map02010 ABC transporters 287.0 16.0 10.0 2.0 0.727272727272727 E 22.0 0.0 1.0 1.0 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 22.0 1.0 0.0 0.0070826884825863 0.0206584781628098 0.013870583322698 0.0135757896802235 0 0 0 0 K17315 0.1114285714285714 0.1139601139601139 gtsA, glcE; glucose/mannose transport system substrate-binding protein path:map02010 ABC transporters 192.0 98.0 91.0 5.0 0.89908256880734 G 58.0 51.0 4.0 0.91743119266055 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 109.0 0.5321100917431193 0.4678899082568807 0.388100919479789 0.619527174798963 0.5038140471393759 0.231426255319174 0 0 0 0 K17316 0.1085714285714285 0.1054131054131054 gtsB, glcF; glucose/mannose transport system permease protein path:map02010 ABC transporters 207.0 113.0 93.0 2.0 0.849624060150376 P 43.0 90.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 133.0 0.3233082706766917 0.6766917293233082 0.639415281087578 0.350891312751682 0.4951532969196299 0.2885239683358959 0 1 0 1 K17317 0.0942857142857142 0.0911680911680911 gtsC, glcG; glucose/mannose transport system permease protein path:map02010 ABC transporters 219.0 62.0 48.0 3.0 0.805194805194805 P 39.0 38.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 77.0 0.5064935064935064 0.4935064935064935 0.384630460961071 0.968148184130214 0.6763893225456425 0.583517723169143 0 0 0 0 K17318 0.0 0.094017094017094 lplA; putative aldouronate transport system substrate-binding protein path:map02010 ABC transporters 117.0 79.0 77.0 3.0 0.963414634146341 G 0.0 82.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 82.0 0.0 1.0 0.0201424680426114 0.0113880323844368 0.0157652502135241 0.0087544356581746 0 0 0 0 K17319 0.0 0.0826210826210826 lplB; putative aldouronate transport system permease protein path:map02010 ABC transporters 255.0 43.0 16.0 4.0 0.597222222222222 G 0.0 72.0 2.0 0.986111111111111 COG4209 ABC-type_polysaccharide_transport_system,_permease_component LplB 72.0 0.0 1.0 0.0989816823093172 0.02384372785484 0.0614127050820786 0.0751379544544772 0 0 0 0 K17320 0.0 0.0883190883190883 lplC; putative aldouronate transport system permease protein path:map02010 ABC transporters 243.0 47.0 17.0 2.0 0.61038961038961 G 0.0 77.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 77.0 0.0 1.0 0.0311781941133669 0.0150578849935327 0.0231180395534498 0.0161203091198341 0 0 0 0 K17321 0.0 0.0455840455840455 glpV; glycerol transport system substrate-binding protein path:map02010 ABC transporters 559.0 17.0 0.0 1.0 1.0 G 0.0 17.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 17.0 0.0 1.0 0.0265303261331814 0.0476708664003908 0.0371005962667861 0.0211405402672094 0 0 0 0 K17322 0.0 0.0512820512820512 glpP; glycerol transport system permease protein path:map02010 ABC transporters 274.0 12.0 5.0 2.0 0.631578947368421 P 0.0 19.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 19.0 0.0 1.0 0.0130246606726549 0.0361536325660866 0.0245891466193707 0.0231289718934317 0 0 0 0 K17323 0.0 0.0512820512820512 glpQ; glycerol transport system permease protein path:map02010 ABC transporters 254.0 12.0 4.0 2.0 0.6 P 0.0 20.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 20.0 0.0 1.0 0.0390272568029506 0.0385133080632874 0.038770282433119 0.0005139487396631 0 0 0 0 K17324 0.0 0.0484330484330484 glpS; glycerol transport system ATP-binding protein path:map02010 ABC transporters 347.0 11.0 6.0 3.0 0.647058823529412 P 0.0 17.0 2.0 0.529411764705882 COG3842 ABC-type_Fe3+/spermidine/putrescine_transport_systems,_ATPase_component PotA 17.0 0.0 1.0 0.0148390614274369 0.0302422321848764 0.0225406468061566 0.0154031707574394 0 0 0 0 K17325 0.0 0.0455840455840455 glpT; glycerol transport system ATP-binding protein path:map02010 ABC transporters 348.0 9.0 2.0 2.0 0.5625 P 0.0 16.0 1.0 1.0 COG3839 ABC-type_sugar_transport_system,_ATPase_component_MalK MalK 16.0 0.0 1.0 0.0255878254441275 0.068765021624985 0.0471764235345562 0.0431771961808575 0 0 0 0 K17326 0.0 0.0085470085470085 bxlE; xylobiose transport system substrate-binding protein path:map02010 ABC transporters 416.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 3.0 0.0 1.0 0 0 0 0 K17327 0.0 0.0227920227920227 bxlF; xylobiose transport system permease protein path:map02010 ABC transporters 281.0 5.0 2.0 2.0 0.625 G 0.0 8.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 8.0 0.0 1.0 0.0280135817483257 0.0489213228086704 0.038467452278498 0.0209077410603447 0 0 0 0 K17328 0.0 0.0085470085470085 bxlG; xylobiose transport system permease protein path:map02010 ABC transporters 269.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 3.0 0.0 1.0 0 0 0 0 K17329 0.0028571428571428 0.0455840455840455 dasA; N,N'-diacetylchitobiose transport system substrate-binding protein path:map02010 ABC transporters 232.0 36.0 0.0 1.0 1.0 G 1.0 35.0 2.0 0.833333333333333 COG1653 ABC-type_glycerol-3-phosphate_transport_system,_periplasmic_component UgpB 36.0 0.0277777777777777 0.9722222222222222 0.0083398089465336 0.013651900942936 0.0109958549447348 0.0053120919964023 0 0 0 0 K17330 0.0 0.037037037037037 dasB; N,N'-diacetylchitobiose transport system permease protein path:map02010 ABC transporters 284.0 12.0 0.0 3.0 0.48 P 0.0 25.0 1.0 1.0 COG1175 ABC-type_sugar_transport_system,_permease_component UgpA 25.0 0.0 1.0 0.0027965509409434 0.0081227533517517 0.0054596521463475 0.0053262024108083 0 0 0 0 K17331 0.0 0.0313390313390313 dasC; N,N'-diacetylchitobiose transport system permease protein path:map02010 ABC transporters 264.0 12.0 2.0 2.0 0.545454545454545 G 0.0 22.0 1.0 1.0 COG0395 ABC-type_glycerol-3-phosphate_transport_system,_permease_component UgpE 22.0 0.0 1.0 9.07025630495297e-05 0.0129589861459059 0.0065248443544777 0.0128682835828563 0 0 0 0 K17362 0.0 0.0028490028490028 ACOT13; acyl-coenzyme A thioesterase 13 [EC:3.1.2.-] 147.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2050 Acyl-CoA_thioesterase_PaaI,_contains_HGG_motif PaaI 1.0 0.0 1.0 0 0 0 0 K17363 0.0028571428571428 0.0113960113960113 urdA; urocanate reductase [EC:1.3.99.33] path:map00340 Histidine metabolism 431.0 7.0 0.0 1.0 1.0 C 1.0 6.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 7.0 0.1428571428571428 0.8571428571428571 0.0646516383451575 0.146467789645652 0.1055597139954047 0.0818161513004945 0 0 0 0 K17364 0.0 0.0085470085470085 dmrA; dihydromethanopterin reductase [EC:1.5.1.47] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 119.0 3.0 0.0 1.0 1.0 H 0.0 3.0 1.0 1.0 COG0262 Dihydrofolate_reductase FolA 3.0 0.0 1.0 0 0 0 0 K17398 0.0 0.0028490028490028 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37] path:map00270,path:map01100,path:map05206 Cysteine and methionine metabolism,Metabolic pathways,MicroRNAs in cancer 324.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG0270 DNA-cytosine_methylase Dcm 1.0 0.0 1.0 0 0 0 0 K17414 0.0 0.0056980056980056 MRPS36; small subunit ribosomal protein S36 517.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG1807 PMT_family_glycosyltransferase_ArnT/Agl22,_involved_in_glycosylation_of_proteins_and_lipid_IVA ArnT 2.0 0.0 1.0 0 0 0 0 K17427 0.0 0.0028490028490028 MRPL46; large subunit ribosomal protein L46 153.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 KOG4548 1.0 0.0 1.0 0 0 0 0 K17440 0.0 0.0085470085470085 MRP49; large subunit ribosomal protein MRP49 453.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG1700 Predicted_anti-virus_defense_system_component_AQ645,_contains_DUF2357_and__PD-(D/E)xK_nuclease_domains AQ645 3.0 0.0 1.0 0 0 0 0 K17462 0.04 0.0427350427350427 yrrT; putative AdoMet-dependent methyltransferase [EC:2.1.1.-] path:map00270,path:map01100,path:map01230 Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of amino acids 103.0 26.0 24.0 3.0 0.866666666666667 Q 15.0 15.0 2.0 0.933333333333333 COG0500 SAM-dependent_methyltransferase SmtA 30.0 0.5 0.5 0.315389086502879 0.0485208269140163 0.1819549567084476 0.2668682595888627 0 0 0 0 K17463 0.0 0.0085470085470085 dgaF; 2-dehydro-3-deoxy-phosphogluconate aldolase [EC:4.1.2.14] path:map00030,path:map01100,path:map01120 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments 238.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2DBAP 3.0 0.0 1.0 0 0 0 0 K17467 0.0057142857142857 0.0113960113960113 dgaD; D-glucosaminate PTS system EIID component path:map00030,path:map01120,path:map02060 Pentose phosphate pathway,Microbial metabolism in diverse environments,Phosphotransferase system (PTS) 174.0 5.0 0.0 1.0 1.0 G 2.0 5.0 3.0 0.571428571428571 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 7.0 0.2857142857142857 0.7142857142857143 0.0185275267023207 0.0716829665839836 0.0451052466431521 0.0531554398816628 0 0 0 0 K17468 0.0 0.0313390313390313 dgaE; D-glucosaminate-6-phosphate ammonia-lyase [EC:4.3.1.29] path:map00030,path:map01120 Pentose phosphate pathway,Microbial metabolism in diverse environments 431.0 10.0 9.0 2.0 0.909090909090909 J 0.0 11.0 1.0 1.0 COG1921 Seryl-tRNA(Sec)_selenium_transferase SelA 11.0 0.0 1.0 0.590905869988688 0.261569031473807 0.4262374507312475 0.329336838514881 0 0 0 1 K17472 0.0 0.0398860398860398 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor 135.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG1959 DNA-binding_transcriptional_regulator,_IscR_family IscR 14.0 0.0 1.0 0.0023656852472758 0.0077170913983571 0.0050413883228164 0.0053514061510813 0 0 0 0 K17473 0.0 0.0028490028490028 dgaR; sigma-54 dependent transcriptional regulator, dga operon transcriptional activator 1036.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1221 Transcriptional_regulators_containing_an_AAA-type_ATPase_domain_and_a_DNA-binding_domain PspF 1.0 0.0 1.0 0 0 0 0 K17474 0.0 0.0 CYP134A, cypX; pulcherriminic acid synthase [EC:1.14.15.13] 2.0 1.0 3.0 0.5 EPQ 0.0 0.0 3.0 0.5 COG0369 Flavoprotein_(flavin_reductase)_subunit_CysJ_of_sulfite_and_N-hydroxylaminopurine_reductases CysJ 0.0 0 0 0 0 K17476 0.0 0.017094017094017 penM, pntM, CYP161C; pentalenolactone synthase [EC:1.14.19.8] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 388.0 9.0 0.0 1.0 1.0 Q 0.0 9.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 9.0 0.0 1.0 0.0006607372235926 0.0034320440936331 0.0020463906586128 0.0027713068700405 0 0 0 0 K17484 0.0028571428571428 0.0028490028490028 E2.3.2.21; cyclo(L-tyrosyl-L-tyrosyl) synthase [EC:2.3.2.21] 218.0 2.0 0.0 1.0 1.0 S 1.0 1.0 1.0 1.0 2EW5R 2.0 0.5 0.5 0 0 0 0 K17485 0.0 0.0028490028490028 yvmC; cyclo(L-leucyl-L-leucyl) synthase [EC:2.3.2.22] 229.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2E8AV 1.0 0.0 1.0 0 0 0 0 K17486 0.0 0.0227920227920227 dmdA; dimethylsulfoniopropionate demethylase [EC:2.1.1.269] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 366.0 9.0 7.0 2.0 0.818181818181818 E 0.0 11.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 11.0 0.0 1.0 0.0223472851331691 0.0429548391736549 0.032651062153412 0.0206075540404858 0 0 0 0 K17487 0.1057142857142857 0.0 mptB; 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [EC:3.1.4.56] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 141.0 37.0 0.0 1.0 1.0 H 37.0 0.0 1.0 1.0 COG3481 3'-5'_exoribonuclease_YhaM,_can_participate_in_23S_rRNA_maturation,__HD_superfamily YhaM 37.0 1.0 0.0 0.983754650871057 0.991039051745946 0.9873968513085014 0.007284400874889 0 0 1 1 K17488 0.4657142857142857 0.0227920227920227 mptA; GTP cyclohydrolase IV [EC:3.5.4.39] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 235.0 169.0 164.0 2.0 0.971264367816092 H 166.0 8.0 2.0 0.954022988505747 COG1469 GTP_cyclohydrolase_FolE2 FolE2 174.0 0.9540229885057472 0.0459770114942528 0.955995494684722 0.97991625676645 0.967955875725586 0.0239207620817279 1 1 1 1 K17489 0.0171428571428571 0.0569800569800569 E2.1.3.1-12S; methylmalonyl-CoA carboxyltransferase 12S subunit [EC:2.1.3.1] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 509.0 29.0 0.0 1.0 1.0 I 6.0 26.0 2.0 0.90625 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 32.0 0.1875 0.8125 0.0544264675708403 0.0040883897890379 0.0292574286799391 0.0503380777818023 0 0 0 0 K17490 0.0142857142857142 0.0142450142450142 E2.1.3.1-1.3S; methylmalonyl-CoA carboxyltransferase 1.3S subunit [EC:2.1.3.1] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 115.0 8.0 6.0 2.0 0.8 I 5.0 5.0 4.0 0.4 COG0511 Biotin_carboxyl_carrier_protein AccB 10.0 0.5 0.5 1.61985555729785e-12 1.0790717919555e-05 5.395359769705279e-06 1.0790716299699442e-05 0 0 0 0 K17495 0.0 0.0028490028490028 CSMD; CUB and sushi domain-containing protein 2691.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG1216 1.0 0.0 1.0 0 0 0 0 K17500 0.0 0.0028490028490028 ILKAP; integrin-linked kinase-associated serine/threonine phosphatase 2C [EC:3.1.3.16] 464.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0631 Serine/threonine_protein_phosphatase_PrpC PTC1 1.0 0.0 1.0 0 0 0 0 K17506 0.0057142857142857 0.0028490028490028 PPM1L, PP2CE; protein phosphatase 1L [EC:3.1.3.16] 100.0 2.0 1.0 3.0 0.5 T 2.0 2.0 2.0 0.5 COG0631 Serine/threonine_protein_phosphatase_PrpC PTC1 4.0 0.5 0.5 0.01428730833683 0.0287445458242569 0.0215159270805434 0.0144572374874268 0 0 0 0 K17512 0.0 0.0028490028490028 SHARK; tyrosine-protein kinase shark [EC:2.7.10.2] path:map04013 MAPK signaling pathway - fly 111.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0515 Serine/threonine_protein_kinase SPS1 1.0 0.0 1.0 0 0 0 0 K17525 0.0028571428571428 0.0 CHID1; chitinase domain-containing protein 1 329.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 1.0 1.0 0.0 0 0 0 0 K17583 0.0 0.0028490028490028 NOM1; nucleolar MIF4G domain-containing protein 1 467.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 1.0 0.0 1.0 0 0 0 0 K17592 0.0028571428571428 0.0028490028490028 SACS; sacsin 580.0 1.0 0.0 1.0 1.0 NU 1.0 1.0 2.0 0.5 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 2.0 0.5 0.5 0 0 0 0 K17609 0.0 0.0028490028490028 NXN; nucleoredoxin [EC:1.8.1.8] 184.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 KOG2501 1.0 0.0 1.0 0 0 0 0 K17615 0.0142857142857142 0.0056980056980056 PPG1; serine/threonine-protein phosphatase PPG1 [EC:3.1.3.16] 256.0 4.0 1.0 2.0 0.571428571428571 GT 5.0 2.0 1.0 1.0 COG0639 Diadenosine_tetraphosphatase_ApaH/serine/threonine_protein_phosphatase,_PP2A_family ApaH 7.0 0.7142857142857143 0.2857142857142857 0.0015532288325114 0.0027049372524867 0.002129083042499 0.0011517084199753 0 0 0 0 K17618 0.0 0.0028490028490028 UBLCP1; ubiquitin-like domain-containing CTD phosphatase 1 [EC:3.1.3.16] 130.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG5190 TFIIF-interacting_CTD_phosphatase,_includes_NLI-interacting_factor FCP1 1.0 0.0 1.0 0 0 0 0 K17619 0.0 0.0028490028490028 MDP1; magnesium-dependent phosphatase 1 [EC:3.1.3.48 3.1.3.-] 152.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG4549 1.0 0.0 1.0 0 0 0 0 K17623 0.0 0.0113960113960113 PUDP, HDHD1; pseudouridine 5'-phosphatase [EC:3.1.3.96] 202.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG0637 Beta-phosphoglucomutase,_HAD_superfamily YcjU 4.0 0.0 1.0 0.0776412767460998 0.172147008751413 0.1248941427487564 0.0945057320053132 0 0 0 0 K17624 0.0 0.0455840455840455 engCP, engBF, endoEF; endo-alpha-N-acetylgalactosaminidase [EC:3.2.1.97] 21.0 5.0 1.0 6.0 0.3125 G 0.0 16.0 11.0 0.1875 COG5492 Uncharacterized_conserved_protein_YjdB,_contains_Ig-like_domain YjdB 16.0 0.0 1.0 0.102743361899379 0.224566838829966 0.1636551003646725 0.121823476930587 0 0 0 0 K17640 0.0 0.0085470085470085 bxlR; LacI family transcriptional regulator, xylobiose transport system transcriptional regulator 318.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1609 DNA-binding_transcriptional_regulator,_LacI/PurR_family PurR 7.0 0.0 1.0 0.0026565807729656 0.0054762953972898 0.0040664380851277 0.0028197146243242 0 0 0 0 K17641 0.0028571428571428 0.0142450142450142 bxlA; beta-xylosidase 729.0 6.0 0.0 1.0 1.0 G 1.0 5.0 2.0 0.666666666666667 COG1472 Periplasmic_beta-glucosidase_and_related_glycosidases BglX 6.0 0.1666666666666666 0.8333333333333334 0.874189355550049 0.276078401433949 0.575133878491999 0.5981109541160999 0 0 1 1 K17662 0.0 0.0598290598290598 CBP3, UQCC; cytochrome b pre-mRNA-processing protein 3 139.0 21.0 0.0 1.0 1.0 S 0.0 21.0 1.0 1.0 COG5452 Uncharacterized_conserved_protein 21.0 0.0 1.0 0.0030397394716528 0.0052563031824692 0.004148021327061 0.0022165637108164 0 0 0 0 K17675 0.0 0.1225071225071225 SUPV3L1, SUV3; ATP-dependent RNA helicase SUPV3L1/SUV3 [EC:3.6.4.13] 376.0 45.0 44.0 3.0 0.957446808510638 L 0.0 47.0 3.0 0.957446808510638 COG4581 Superfamily_II_RNA_helicase Dob10 47.0 0.0 1.0 0.0210590114651098 0.0331619821811209 0.0271104968231153 0.0121029707160111 0 0 0 0 K17680 0.0142857142857142 0.0968660968660968 PEO1; twinkle protein [EC:5.6.2.3] path:map05017 Spinocerebellar ataxia 27.0 51.0 50.0 4.0 0.944444444444444 L 6.0 44.0 4.0 0.574074074074074 COG0358 DNA_primase_(bacterial_type) DnaG 50.0 0.12 0.88 0.399276777145391 0.256263348819909 0.32777006298265 0.143013428325482 0 0 0 0 K17681 0.0028571428571428 0.0142450142450142 ATAD3A_B; ATPase family AAA domain-containing protein 3A/B 242.0 4.0 2.0 2.0 0.666666666666667 O 1.0 5.0 2.0 0.5 COG1222 ATP-dependent_26S_proteasome_regulatory_subunit RPT1 6.0 0.1666666666666666 0.8333333333333334 0.153283883700345 0.464689220631223 0.3089865521657839 0.3114053369308779 0 0 0 0 K17686 0.6514285714285715 0.8290598290598291 copA, ctpA, ATP7; P-type Cu+ transporter [EC:7.2.2.8] path:map01524,path:map04016,path:map04978 Platinum drug resistance,MAPK signaling pathway - plant,Mineral absorption 149.0 842.0 764.0 4.0 0.906350914962325 P 374.0 533.0 10.0 0.845824411134904 COG2217 Cation-transporting_P-type_ATPase ZntA 907.0 0.412348401323043 0.587651598676957 0.43874757558432 0.56946535374772 0.50410646466602 0.1307177781634 0 0 0 0 K17713 0.0885714285714285 0.2079772079772079 bamB; outer membrane protein assembly factor BamB 20.0 69.0 37.0 8.0 0.514925373134328 S 42.0 96.0 5.0 0.942028985507247 COG1520 Outer_membrane_protein_assembly_factor_BamB,_contains_PQQ-like_beta-propeller_repeat PQQ 138.0 0.3043478260869565 0.6956521739130435 0.0152023627265394 0.0358678979122143 0.0255351303193768 0.0206655351856748 0 0 0 0 K17716 0.0171428571428571 0.1025641025641025 capD; UDP-glucose 4-epimerase [EC:5.1.3.2] path:map00052,path:map00520,path:map00541,path:map01100,path:map01250 Galactose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 301.0 30.0 17.0 2.0 0.697674418604651 M 6.0 37.0 1.0 1.0 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 43.0 0.1395348837209302 0.8604651162790697 0.11996188613955 0.768954422214567 0.4444581541770585 0.6489925360750171 0 0 0 0 K17717 0.02 0.017094017094017 pld; phospholipase D [EC:3.1.4.4] path:map00564,path:map00565,path:map01100,path:map01110 Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 227.0 13.0 0.0 1.0 1.0 I 7.0 6.0 1.0 1.0 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin_synthase Cls 13.0 0.5384615384615384 0.4615384615384615 0.0129953553326009 0.0663830301952802 0.0396891927639405 0.0533876748626793 0 0 0 0 K17722 0.0 0.1082621082621082 preT; dihydropyrimidine dehydrogenase (NAD+) subunit PreT [EC:1.3.1.1] path:map00240,path:map00410,path:map00770,path:map01100 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways 372.0 28.0 17.0 2.0 0.717948717948718 C 0.0 39.0 1.0 1.0 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 39.0 0.0 1.0 0.0020389892053843 0.0273938327167264 0.0147164109610553 0.0253548435113421 0 0 0 0 K17723 0.1171428571428571 0.131054131054131 preA; dihydropyrimidine dehydrogenase (NAD+) subunit PreA [EC:1.3.1.1] path:map00240,path:map00410,path:map00770,path:map01100 Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways 178.0 50.0 19.0 4.0 0.537634408602151 C 45.0 48.0 4.0 0.935483870967742 COG0167 Dihydroorotate_dehydrogenase PyrD 93.0 0.4838709677419355 0.5161290322580645 0.981435972731442 0.956139002431811 0.9687874875816264 0.0252969702996309 1 1 1 1 K17733 0.0028571428571428 0.1082621082621082 cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-] 12.0 36.0 29.0 4.0 0.782608695652174 M 1.0 44.0 12.0 0.478260869565217 COG1876 LD-carboxypeptidase_LdcB,_LAS_superfamily LdcB 45.0 0.0222222222222222 0.9777777777777776 0.0941868940034374 0.524111752319919 0.3091493231616782 0.4299248583164816 0 0 0 0 K17734 0.1914285714285714 0.0968660968660968 aprX; serine protease AprX [EC:3.4.21.-] 58.0 141.0 113.0 6.0 0.805714285714286 O 124.0 52.0 6.0 0.874285714285714 COG1404 Serine_protease,_subtilisin_family AprE 176.0 0.7045454545454546 0.2954545454545454 0.915276497630245 0.943952631679364 0.9296145646548044 0.028676134049119 1 1 1 1 K17735 0.0 0.0598290598290598 lcdH, cdhA; carnitine 3-dehydrogenase [EC:1.1.1.108] 299.0 21.0 18.0 2.0 0.875 I 0.0 24.0 2.0 0.75 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 24.0 0.0 1.0 0.004275273720916 0.0345612810059058 0.0194182773634109 0.0302860072849898 0 0 0 0 K17736 0.0 0.0142450142450142 cdhR; AraC family transcriptional regulator, carnitine catabolism transcriptional activator 245.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG4977 Transcriptional_regulator_GlxA,_contains_an_amidase_domain_and_an_AraC-type_DNA-binding_HTH_domain GlxA 6.0 0.0 1.0 4.62540512952293e-12 0.0674605930589891 0.0337302965318072 0.0674605930543637 0 0 0 0 K17737 0.0 0.0113960113960113 dhcR; LysR family transcriptional regulator, carnitine catabolism transcriptional activator 295.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 6.0 0.0 1.0 1.2234623091715e-06 2.96519246441094e-06 2.09432738679122e-06 1.74173015523944e-06 0 0 0 0 K17743 0.0 0.0142450142450142 XR; D-xylose reductase [EC:1.1.1.307] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 323.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG0656 Aldo/keto_reductase,_related_to_diketogulonate_reductase ARA1 5.0 0.0 1.0 3.26944757446152e-12 6.86723441217445e-12 5.068340993317985e-12 3.5977868377129307e-12 0 0 0 0 K17744 0.0 0.0199430199430199 GalDH; L-galactose dehydrogenase [EC:1.1.1.316] path:map00053,path:map01100,path:map01110,path:map01240 Ascorbate and aldarate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 308.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 7.0 0.0 1.0 0.0513325945229908 0.090615358912484 0.0709739767177373 0.0392827643894932 0 0 0 0 K17745 0.0 0.0113960113960113 spr1; sepiapterin reductase [EC:1.1.1.325] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 230.0 3.0 2.0 2.0 0.75 S 0.0 4.0 1.0 1.0 COG4221 NADP-dependent_3-hydroxy_acid_dehydrogenase_YdfG YdfG 4.0 0.0 1.0 6.51943025086757e-06 7.50065168918843e-06 7.010040970028e-06 9.812214383208595e-07 0 0 0 0 K17748 0.0 0.0056980056980056 hphA; benzylmalate synthase [EC:2.3.3.-] path:map00400,path:map01100 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways 391.0 1.0 0.0 2.0 0.5 E 0.0 2.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 2.0 0.0 1.0 0 0 0 0 K17749 0.0028571428571428 0.0085470085470085 hphCD; 3-benzylmalate isomerase [EC:4.2.1.-] path:map00400,path:map01100 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways 382.0 3.0 2.0 2.0 0.75 E 1.0 3.0 1.0 1.0 COG0065 Homoaconitase/3-isopropylmalate_dehydratase_large_subunit LeuC 4.0 0.25 0.75 0.113308781767744 0.265311565330601 0.1893101735491725 0.152002783562857 0 0 0 0 K17750 0.0 0.0056980056980056 hphB; 3-benzylmalate dehydrogenase [EC:1.1.1.-] path:map00400,path:map01100 Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways 344.0 1.0 0.0 2.0 0.5 CE 0.0 2.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 2.0 0.0 1.0 0 0 0 0 K17752 0.0085714285714285 0.1139601139601139 rsbT; serine/threonine-protein kinase RsbT [EC:2.7.11.1] 57.0 69.0 0.0 1.0 1.0 T 4.0 65.0 2.0 0.971014492753623 COG2172 Anti-sigma_regulatory_factor_(Ser/Thr_protein_kinase) RsbW 69.0 0.0579710144927536 0.9420289855072465 0.0028988288628996 0.0458819912587731 0.0243904100608363 0.0429831623958735 0 0 0 0 K17753 0.0028571428571428 0.0 HICDH; isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286] path:map00020,path:map00300,path:map01100,path:map01110,path:map01120,path:map01210,path:map01230 Citrate cycle (TCA cycle),Lysine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 345.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG0473 Isocitrate/isopropylmalate_dehydrogenase LeuB 1.0 1.0 0.0 0 0 0 0 K17754 0.0028571428571428 0.0142450142450142 cpnA; cyclopentanol dehydrogenase [EC:1.1.1.163] path:map00930,path:map01220 Caprolactam degradation,Degradation of aromatic compounds 169.0 7.0 0.0 1.0 1.0 IQ 1.0 6.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 7.0 0.1428571428571428 0.8571428571428571 0.0191230216784249 0.0575773628186211 0.038350192248523 0.0384543411401962 0 0 0 0 K17755 0.0 0.017094017094017 codA; choline oxidase [EC:1.1.3.17] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 513.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 6.0 0.0 1.0 7.71083011357574e-05 0.0007452481767386 0.0004111782389371 0.0006681398756028 0 0 0 0 K17758 0.7628571428571429 0.792022792022792 nnrD; ADP-dependent NAD(P)H-hydrate dehydratase [EC:4.2.1.136] 73.0 419.0 250.0 3.0 0.704201680672269 G 296.0 299.0 3.0 0.564705882352941 COG0063 NAD(P)H-hydrate_repair_enzyme_Nnr,_NAD(P)H-hydrate_dehydratase_domain Nnr2 595.0 0.4974789915966386 0.5025210084033613 0.239861830942272 0.186187452824478 0.213024641883375 0.053674378117794 0 0 0 0 K17759 0.7514285714285714 0.7749287749287749 NAXE, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6] 89.0 416.0 238.0 2.0 0.7003367003367 G 292.0 302.0 2.0 0.545454545454545 COG0063 NAD(P)H-hydrate_repair_enzyme_Nnr,_NAD(P)H-hydrate_dehydratase_domain Nnr2 594.0 0.4915824915824915 0.5084175084175084 0.0017397708649533 0.177246154319546 0.0894929625922496 0.1755063834545926 0 0 0 0 K17760 0.0028571428571428 0.0284900284900284 qheDH, qbdA; quinohemoprotein ethanol dehydrogenase [EC:1.1.9.1] 239.0 11.0 6.0 3.0 0.578947368421053 C 3.0 16.0 2.0 0.894736842105263 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 19.0 0.1578947368421052 0.8421052631578947 0.0134978883377462 0.021732437019726 0.0176151626787361 0.0082345486819797 0 0 0 0 K17762 0.0085714285714285 0.0797720797720797 rsbS; rsbT antagonist protein RsbS 110.0 31.0 0.0 1.0 1.0 T 3.0 28.0 1.0 1.0 COG1366 Anti-anti-sigma_regulatory_factor_(antagonist_of_anti-sigma_factor) SpoIIAA 31.0 0.0967741935483871 0.9032258064516128 0.0044222280033448 0.0242172180935011 0.0143197230484229 0.0197949900901563 0 0 0 0 K17763 0.0142857142857142 0.1367521367521367 rsbR; rsbT co-antagonist protein RsbR 23.0 105.0 102.0 4.0 0.929203539823009 T 8.0 105.0 13.0 0.778761061946903 COG1366 Anti-anti-sigma_regulatory_factor_(antagonist_of_anti-sigma_factor) SpoIIAA 113.0 0.0707964601769911 0.9292035398230089 0.001282319254624 0.0057578695758606 0.0035200944152423 0.0044755503212366 0 0 0 0 K17768 0.0 0.0113960113960113 TOM70; mitochondrial import receptor subunit TOM70 158.0 4.0 0.0 1.0 1.0 U 0.0 4.0 1.0 1.0 KOG0547 4.0 0.0 1.0 0.950539455869808 0.336799140148054 0.643669298008931 0.613740315721754 0 0 1 1 K17781 0.0 0.0028490028490028 TIM13; mitochondrial import inner membrane translocase subunit TIM13 458.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0153 Galactokinase GalK 1.0 0.0 1.0 0 0 0 0 K17785 0.0057142857142857 0.0 IMMT, MIC60; MICOS complex subunit MIC60 179.0 2.0 0.0 1.0 1.0 U 2.0 0.0 1.0 1.0 KOG0092 2.0 1.0 0.0 0 0 0 0 K17804 0.0028571428571428 0.0 TIM44; mitochondrial import inner membrane translocase subunit TIM44 255.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG0468 RecA/RadA_recombinase RecA 1.0 1.0 0.0 0 0 0 0 K17807 0.0028571428571428 0.0 TAM41, MMP37; mitochondrial translocator assembly and maintenance protein 41 316.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 KOG2986 2.0 1.0 0.0 0 0 0 0 K17810 0.0 0.0569800569800569 asl; D-aspartate ligase [EC:6.3.1.12] 257.0 17.0 12.0 2.0 0.772727272727273 S 0.0 22.0 1.0 1.0 COG3919 Predicted_ATP-dependent_carboligase,_ATP-grasp_superfamily 22.0 0.0 1.0 0.308647882948238 0.0768811215865319 0.1927645022673849 0.231766761361706 0 0 0 0 K17811 0.0028571428571428 0.017094017094017 K17811; halimadienyl-diphosphate synthase [EC:5.5.1.16] 398.0 7.0 0.0 1.0 1.0 I 1.0 6.0 1.0 1.0 COG1657 Terpene_cyclase_SqhC SqhC 7.0 0.1428571428571428 0.8571428571428571 0.0208710453534161 0.123775958633091 0.0723235019932535 0.1029049132796749 0 0 0 0 K17815 0.0057142857142857 0.0 EXO5; exonuclease V [EC:3.1.-.-] 261.0 2.0 0.0 1.0 1.0 F 2.0 0.0 1.0 1.0 KOG4760 2.0 1.0 0.0 0 0 0 0 K17816 0.0228571428571428 0.0455840455840455 NUDT1, MTH1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 121.0 18.0 13.0 3.0 0.72 F 8.0 17.0 2.0 0.72 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 25.0 0.32 0.68 0.0613416481858477 0.493739724554375 0.2775406863701113 0.4323980763685273 0 0 0 0 K17817 0.0028571428571428 0.0 NUDT18, MTH3; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 146.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 KOG0648 1.0 1.0 0.0 0 0 0 0 K17818 0.0028571428571428 0.0085470085470085 ARD1; D-arabinitol dehydrogenase (NADP+) [EC:1.1.1.287] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 294.0 3.0 2.0 2.0 0.75 C 1.0 3.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 4.0 0.25 0.75 0.0790437112646186 0.153704779864825 0.1163742455647218 0.0746610686002064 0 0 0 0 K17828 0.5428571428571428 0.5270655270655271 pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] path:map00240,path:map01100,path:map01240 Pyrimidine metabolism,Metabolic pathways,Biosynthesis of cofactors 137.0 386.0 382.0 4.0 0.977215189873418 F 194.0 201.0 2.0 0.987341772151899 COG0167 Dihydroorotate_dehydrogenase PyrD 395.0 0.4911392405063291 0.5088607594936709 0.793379767399063 0.832525372352871 0.812952569875967 0.039145604953808 1 1 1 1 K17829 0.0 0.0341880341880341 ccrA; crotonyl-CoA reductase [EC:1.3.1.86] path:map00650,path:map01100,path:map01110,path:map01120,path:map01200 Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 439.0 16.0 0.0 1.0 1.0 C 0.0 16.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 16.0 0.0 1.0 0.0105118555516464 0.0231625522148118 0.0168372038832291 0.0126506966631654 0 0 0 0 K17830 0.6885714285714286 0.0541310541310541 GGR; digeranylgeranylglycerophospholipid reductase [EC:1.3.1.101 1.3.7.11] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 71.0 400.0 0.0 1.0 1.0 C 375.0 22.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 397.0 0.9445843828715366 0.0554156171284634 0.806485507415652 0.858601813492154 0.8325436604539029 0.052116306076502 1 1 1 1 K17835 0.0 0.0056980056980056 griH; 3-amino-4-hydroxybenzoic acid synthase [EC:4.1.99.20] path:map00997,path:map01100,path:map01110 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 341.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG1465 3-dehydroquinate_synthase,_class_II AroB2 3.0 0.0 1.0 0 0 0 0 K17836 0.0285714285714285 0.3048433048433048 penP; beta-lactamase class A [EC:3.5.2.6] path:map00311,path:map01110,path:map01501 Penicillin and cephalosporin biosynthesis,Biosynthesis of secondary metabolites,beta-Lactam resistance 77.0 171.0 166.0 5.0 0.955307262569832 V 10.0 170.0 6.0 0.960893854748603 COG2367 Beta-lactamase_class_A PenP 180.0 0.0555555555555555 0.9444444444444444 0.0169132563651953 0.976355218879781 0.4966342376224881 0.9594419625145858 0 0 0 0 K17837 0.0114285714285714 0.0911680911680911 bla2, blm, ccrA, blaB; metallo-beta-lactamase class B [EC:3.5.2.6] path:map01501 beta-Lactam resistance 95.0 38.0 36.0 3.0 0.926829268292683 S 4.0 37.0 1.0 1.0 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 41.0 0.0975609756097561 0.902439024390244 0.0213415365299754 0.0816765709424721 0.0515090537362237 0.0603350344124967 0 0 0 0 K17838 0.0028571428571428 0.0683760683760683 oxa; beta-lactamase class D [EC:3.5.2.6] path:map01501 beta-Lactam resistance 193.0 21.0 16.0 2.0 0.807692307692308 V 1.0 25.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 26.0 0.0384615384615384 0.9615384615384616 0.0320705141437961 0.0583865856041669 0.0452285498739815 0.0263160714603708 0 0 0 0 K17840 0.0057142857142857 0.0541310541310541 aac2-I; aminoglycoside 2'-N-acetyltransferase I [EC:2.3.1.59] 43.0 17.0 12.0 2.0 0.772727272727273 K 2.0 20.0 3.0 0.545454545454545 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 22.0 0.0909090909090909 0.9090909090909092 0.057895838510749 0.116435639481319 0.087165738996034 0.05853980097057 0 0 0 0 K17850 0.0 0.0256410256410256 ampR; LysR family transcriptional regulator, regulator of gene expression of beta-lactamase path:map01501 beta-Lactam resistance 286.0 9.0 0.0 1.0 1.0 K 0.0 9.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 9.0 0.0 1.0 0.0231908812239608 0.0558105107526131 0.0395006959882869 0.0326196295286523 0 0 0 0 K17851 0.0342857142857142 0.0 dpd; D-proline dehydrogenase [EC:1.5.99.13] path:map00330,path:map00470,path:map01100 Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways 351.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 15.0 1.0 0.0 0.0091946179277413 5.28936382007203e-12 0.0045973089665153 0.0091946179224519 0 0 0 0 K17865 0.1342857142857142 0.1595441595441595 croR; 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] path:map00630,path:map00650,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 103.0 115.0 113.0 2.0 0.982905982905983 I 54.0 63.0 2.0 0.982905982905983 COG2030 Acyl-CoA_dehydratase_PaaZ MaoC 117.0 0.4615384615384615 0.5384615384615384 0.0002065088441869 0.900565684955616 0.4503860968999014 0.900359176111429 0 0 0 0 K17866 0.0028571428571428 0.0 DPH2; diphthamide biosynthesis protein 2 87.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1736 Diphthamide_synthase_subunit_DPH2 DPH2 1.0 1.0 0.0 0 0 0 0 K17867 0.0 0.0142450142450142 DPH4, DNAJC24; diphthamide biosynthesis protein 4 86.0 4.0 3.0 2.0 0.8 O 0.0 5.0 1.0 1.0 COG0484 DnaJ-class_molecular_chaperone_with_C-terminal_Zn_finger_domain DnaJ 5.0 0.0 1.0 0.0213778513212442 0.694680422057262 0.358029136689253 0.6733025707360178 0 0 0 0 K17869 0.0 0.0199430199430199 nox2; NADH oxidase (H2O-forming) [EC:1.6.3.4] 449.0 4.0 2.0 3.0 0.571428571428571 S 0.0 7.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 7.0 0.0 1.0 0.0051525617872269 3.33590633069167e-05 0.0025929604252669 0.0051192027239199 0 0 0 0 K17870 0.2285714285714285 0.0028490028490028 nox1; NADH oxidase (H2O2-forming) [EC:1.6.3.3] 378.0 71.0 53.0 2.0 0.797752808988764 P 88.0 1.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 89.0 0.9887640449438202 0.0112359550561797 0.954687455216534 0.988352079410774 0.971519767313654 0.0336646241942399 0 0 1 1 K17876 0.0 0.0142450142450142 CYP105D; pentalenic acid synthase [EC:1.14.15.11] path:map00998,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Biosynthesis of secondary metabolites 365.0 6.0 5.0 2.0 0.857142857142857 C 0.0 7.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 7.0 0.0 1.0 0.0079391389561861 0.0158067752526124 0.0118729571043992 0.0078676362964263 0 0 0 0 K17877 0.0 0.0028490028490028 NIT-6; nitrite reductase (NAD(P)H) [EC:1.7.1.4] path:map00910,path:map01100,path:map01120 Nitrogen metabolism,Metabolic pathways,Microbial metabolism in diverse environments 379.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 1.0 0.0 1.0 0 0 0 0 K17878 0.0 0.0028490028490028 NNT1; EEF1A N-terminal glycine/lysine methyltransferase [EC:2.1.1.-] 398.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3897 Protein_N-terminal_and_lysine_N-methylase,_NNT1/EFM7_family Nnt1 1.0 0.0 1.0 0 0 0 0 K17880 0.0057142857142857 0.0085470085470085 hyg; hygromycin-B 7''-O-kinase [EC:2.7.1.119] 277.0 5.0 0.0 1.0 1.0 S 2.0 3.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 5.0 0.4 0.6 0.401978254211704 0.790281043392563 0.5961296488021335 0.388302789180859 0 0 0 0 K17882 0.0085714285714285 0.0199430199430199 aadD, knt; kanamycin nucleotidyltransferase [EC:2.7.7.-] 80.0 11.0 0.0 1.0 1.0 S 5.0 7.0 3.0 0.833333333333333 COG1708 Predicted_nucleotidyltransferase,_MJ0604_family MJ0604 12.0 0.4166666666666667 0.5833333333333334 0.0273443941665686 0.0668150758623297 0.0470797350144491 0.039470681695761 0 0 0 0 K17883 0.0028571428571428 0.0427350427350427 mtr; mycothione reductase [EC:1.8.1.15] 431.0 17.0 0.0 1.0 1.0 C 1.0 16.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 17.0 0.0588235294117647 0.9411764705882352 0.019135855674653 0.0300365694572602 0.0245862125659566 0.0109007137826072 0 0 0 0 K17884 0.6485714285714286 0.0313390313390313 E2.7.8.39; archaetidylinositol phosphate synthase [EC:2.7.8.39] 110.0 284.0 0.0 1.0 1.0 I 272.0 12.0 1.0 1.0 COG0558 Phosphatidylglycerophosphate_synthase PgsA 284.0 0.9577464788732394 0.0422535211267605 0.0424189485641229 0.437165570886021 0.2397922597250719 0.394746622321898 0 0 0 0 K17890 0.0028571428571428 0.0 ATG16L1; autophagy-related protein 16-1 path:map04136,path:map04138,path:map04140,path:map04621,path:map05131 Autophagy - other,Autophagy - yeast,Autophagy - animal,NOD-like receptor signaling pathway,Shigellosis 382.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 KOG0288 1.0 1.0 0.0 0 0 0 0 K17892 0.0 0.0427350427350427 FTRC; ferredoxin-thioredoxin reductase catalytic chain [EC:1.8.7.2] 115.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG4802 Ferredoxin-thioredoxin_reductase,_catalytic_subunit FtrB 15.0 0.0 1.0 0.0033100114286394 0.00692015023773 0.0051150808331846 0.0036101388090906 0 0 0 0 K17893 0.0 0.017094017094017 AOX1, AOX2; ubiquinol oxidase [EC:1.10.3.11] 152.0 6.0 5.0 2.0 0.857142857142857 H 0.0 7.0 2.0 0.857142857142857 COG2941 Demethoxyubiquinone_hydroxylase,_CLK1/Coq7/Cat5_family_(ubiquinone_biosynthesis) Coq7 7.0 0.0 1.0 0.127093184668254 0.161094731205483 0.1440939579368685 0.034001546537229 0 0 0 0 K17898 0.0 0.0484330484330484 oraE; D-ornithine 4,5-aminomutase subunit beta [EC:5.4.3.5] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 724.0 14.0 12.0 3.0 0.777777777777778 S 0.0 18.0 2.0 0.888888888888889 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 18.0 0.0 1.0 0.0658285848747369 0.212884162580048 0.1393563737273924 0.147055577705311 0 0 0 0 K17899 0.0028571428571428 0.0484330484330484 oraS; D-ornithine 4,5-aminomutase subunit alpha [EC:5.4.3.5] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 119.0 18.0 0.0 1.0 1.0 S 1.0 17.0 1.0 1.0 2DMJP 18.0 0.0555555555555555 0.9444444444444444 0.101773090432787 0.161939456710198 0.1318562735714925 0.0601663662774109 0 0 0 0 K17910 0.0228571428571428 0.0113960113960113 aphD; aminoglycoside 2''-phosphotransferase [EC:2.7.1.190] 203.0 12.0 11.0 2.0 0.923076923076923 S 8.0 5.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 13.0 0.6153846153846154 0.3846153846153846 0.035517859702254 0.336642424198261 0.1860801419502575 0.301124564496007 0 0 0 0 K17938 0.0 0.0313390313390313 sbmA, bacA; peptide/bleomycin uptake transporter 322.0 10.0 9.0 2.0 0.909090909090909 I 0.0 11.0 1.0 1.0 COG1133 Peptide_antibiotic_transporter_SbmA/BacA,_ABC-type_permease_family SbmA 11.0 0.0 1.0 0.0046620222296628 0.0602427761203604 0.0324523991750116 0.0555807538906976 0 0 0 0 K17942 0.1542857142857142 0.0 pmd; phosphomevalonate decarboxylase [EC:4.1.1.99] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 308.0 55.0 0.0 1.0 1.0 I 55.0 0.0 1.0 1.0 COG3407 Mevalonate_pyrophosphate_decarboxylase MVD1 55.0 1.0 0.0 0.00153479318681 0.518728103098321 0.2601314481425655 0.5171933099115109 0 0 0 0 K17947 0.1828571428571428 0.1481481481481481 wbiB; dTDP-L-rhamnose 4-epimerase [EC:5.1.3.25] path:map00523,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 191.0 100.0 69.0 2.0 0.763358778625954 M 73.0 58.0 2.0 0.83206106870229 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 131.0 0.5572519083969466 0.4427480916030534 0.655558599429723 0.869677005010186 0.7626178022199546 0.2141184055804629 0 1 0 1 K17948 0.0 0.0056980056980056 nanM; N-acetylneuraminate epimerase [EC:5.1.3.24] 363.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG3055 N-acetylneuraminic_acid_mutarotase NanM 2.0 0.0 1.0 0 0 0 0 K17950 0.0142857142857142 0.0512820512820512 cuyA; L-cysteate sulfo-lyase [EC:4.4.1.25] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 279.0 28.0 27.0 2.0 0.96551724137931 E 6.0 23.0 1.0 1.0 COG2515 1-aminocyclopropane-1-carboxylate_deaminase/D-cysteine_desulfhydrase,_PLP-dependent_ACC_family Acd 29.0 0.2068965517241379 0.7931034482758621 0.0306231918524574 0.147155248890251 0.0888892203713542 0.1165320570377936 0 0 0 0 K17981 0.0028571428571428 0.0 MTFP1, MTP18; mitochondrial fission process protein 1 183.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 KOG4268 1.0 1.0 0.0 0 0 0 0 K17982 0.0 0.0028490028490028 TPS04, GES; geranyllinalool synthase [EC:4.2.3.144] path:map00904,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Biosynthesis of secondary metabolites 132.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0055 FoF1-type_ATP_synthase,_beta_subunit AtpD 1.0 0.0 1.0 0 0 0 0 K17987 0.0 0.0056980056980056 NBR1; next to BRCA1 gene 1 protein path:map04137 Mitophagy - animal 173.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 KOG4351 3.0 0.0 1.0 0 0 0 0 K17989 0.0 0.017094017094017 SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19] path:map00260,path:map00270,path:map00290,path:map01100,path:map01110,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Cysteine and methionine metabolism,Valine, leucine and isoleucine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism,Biosynthesis of amino acids 294.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG1171 Threonine_deaminase IlvA 6.0 0.0 1.0 0.0578037227474597 0.115649394753343 0.0867265587504013 0.0578456720058833 0 0 0 0 K17992 0.0 0.1282051282051282 hndB; NADP-reducing hydrogenase subunit HndB [EC:1.12.1.3] 88.0 50.0 0.0 1.0 1.0 C 0.0 50.0 2.0 0.94 COG3411 2Fe-2S_ferredoxin 50.0 0.0 1.0 0.617579663866026 0.862041426255358 0.739810545060692 0.2444617623893319 0 0 0 1 K17993 0.1114285714285714 0.0056980056980056 hydA; sulfhydrogenase subunit alpha [EC:1.12.1.3 1.12.1.5] path:map00920,path:map01120 Sulfur metabolism,Microbial metabolism in diverse environments 366.0 47.0 0.0 1.0 1.0 C 45.0 2.0 1.0 1.0 COG0374 Ni,Fe-hydrogenase_I_large_subunit HyaB 47.0 0.9574468085106383 0.0425531914893617 0.0113343348250278 0.923579137675741 0.4674567362503843 0.9122448028507132 0 0 0 0 K17994 0.1142857142857142 0.0 hydD; sulfhydrogenase subunit delta [EC:1.12.1.3 1.12.1.5] path:map00920,path:map01120 Sulfur metabolism,Microbial metabolism in diverse environments 213.0 45.0 0.0 1.0 1.0 C 45.0 0.0 1.0 1.0 COG1941 Coenzyme_F420-reducing_hydrogenase,_gamma_subunit FrhG 45.0 1.0 0.0 0.917419585495414 0.807284694646611 0.8623521400710126 0.110134890848803 0 0 1 1 K17995 0.1114285714285714 0.0 hydG; sulfhydrogenase subunit gamma (sulfur reductase) [EC:1.12.98.4] path:map00920,path:map01120 Sulfur metabolism,Microbial metabolism in diverse environments 212.0 49.0 0.0 1.0 1.0 C 49.0 0.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 49.0 1.0 0.0 0.22699717054381 0.890663517072333 0.5588303438080715 0.6636663465285231 0 0 0 0 K17996 0.1057142857142857 0.0056980056980056 hydB; sulfhydrogenase subunit beta (sulfur reductase) [EC:1.12.98.4] path:map00920,path:map01120 Sulfur metabolism,Microbial metabolism in diverse environments 269.0 44.0 0.0 1.0 1.0 C 42.0 2.0 1.0 1.0 COG1145 Ferredoxin NapF 44.0 0.9545454545454546 0.0454545454545454 0.901874458598467 0.941570209617669 0.921722334108068 0.0396957510192019 0 0 1 1 K17997 0.0 0.0142450142450142 hydA; iron-hydrogenase subunit alpha [EC:1.12.1.4] 653.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 5.0 0.0 1.0 0.984780091645844 0.589972801605712 0.787376446625778 0.394807290040132 0 0 1 1 K17998 0.0 0.0113960113960113 hydB; iron-hydrogenase subunit beta [EC:1.12.1.4] 595.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 5.0 0.0 1.0 0.994089611779782 0.439892878924989 0.7169912453523855 0.554196732854793 0 0 1 1 K17999 0.0057142857142857 0.0256410256410256 hydC; iron-hydrogenase subunit gamma [EC:1.12.1.4] 157.0 11.0 0.0 1.0 1.0 C 2.0 9.0 1.0 1.0 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 11.0 0.1818181818181818 0.8181818181818182 0.98596999733665 0.752067061471354 0.869018529404002 0.2339029358652959 0 0 1 1 K18002 0.0 0.0 pqsC; 2-heptyl-4(1H)-quinolone synthase subunit PqsC [EC:2.3.1.230] path:map00405,path:map01110,path:map02024,path:map02025 Phenazine biosynthesis,Biosynthesis of secondary metabolites,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 8.0 7.0 2.0 0.888888888888889 C 0.0 0.0 2.0 0.888888888888889 COG0022 Pyruvate/2-oxoglutarate/acetoin_dehydrogenase_complex,_dehydrogenase_(E1)_component,_beta_subunit AcoB 0.0 0 0 0 0 K18003 0.0 0.0142450142450142 pqsD; anthraniloyl-CoA anthraniloyltransferase [EC:2.3.1.262] path:map00405,path:map01110,path:map02024,path:map02025 Phenazine biosynthesis,Biosynthesis of secondary metabolites,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 329.0 5.0 0.0 1.0 1.0 I 0.0 5.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 5.0 0.0 1.0 0.0074316374584854 0.0882671771394503 0.0478494072989678 0.0808355396809649 0 0 0 0 K18005 0.0 0.0455840455840455 hoxF; [NiFe] hydrogenase diaphorase moiety large subunit [EC:1.12.1.2] 329.0 18.0 0.0 1.0 1.0 C 0.0 18.0 2.0 0.888888888888889 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 18.0 0.0 1.0 0.082855717743394 0.398193388684023 0.2405245532137085 0.315337670940629 0 0 0 0 K18006 0.0 0.0484330484330484 hoxU; [NiFe] hydrogenase diaphorase moiety small subunit [EC:1.12.1.2] 225.0 18.0 0.0 1.0 1.0 C 0.0 18.0 4.0 0.666666666666667 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 18.0 0.0 1.0 0.0797680593351633 0.62116464725675 0.3504663532959566 0.5413965879215867 0 0 0 0 K18007 0.04 0.0826210826210826 hoxY; NAD-reducing hydrogenase small subunit [EC:1.12.1.2] 139.0 44.0 0.0 1.0 1.0 C 14.0 30.0 3.0 0.954545454545455 COG1941 Coenzyme_F420-reducing_hydrogenase,_gamma_subunit FrhG 44.0 0.3181818181818182 0.6818181818181818 0.308796960336223 0.389145287292121 0.348971123814172 0.080348326955898 0 0 0 0 K18008 0.0 0.037037037037037 hydA; [NiFe] hydrogenase small subunit [EC:1.12.2.1] 304.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 COG1740 Ni,Fe-hydrogenase_I_small_subunit HyaA 13.0 0.0 1.0 0.0096169575707609 0.0334885811598427 0.0215527693653018 0.0238716235890818 0 0 0 0 K18009 0.0342857142857142 0.0512820512820512 budC; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] path:map00650,path:map01110 Butanoate metabolism,Biosynthesis of secondary metabolites 209.0 32.0 29.0 2.0 0.914285714285714 IQ 13.0 22.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 35.0 0.3714285714285714 0.6285714285714286 0.034922012975229 0.622103309732671 0.32851266135395 0.587181296757442 0 0 0 0 K18011 0.0057142857142857 0.0569800569800569 kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3] path:map00310,path:map00470,path:map01100 Lysine degradation,D-Amino acid metabolism,Metabolic pathways 244.0 14.0 6.0 2.0 0.636363636363636 S 2.0 20.0 2.0 0.636363636363636 COG5012 Methanogenic_corrinoid_protein_MtbC1 MtbC1 22.0 0.0909090909090909 0.9090909090909092 0.196742395855367 0.828773028800906 0.5127577123281365 0.632030632945539 0 0 0 0 K18012 0.0057142857142857 0.0598290598290598 kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 333.0 12.0 2.0 3.0 0.5 E 2.0 22.0 3.0 0.5 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 24.0 0.0833333333333333 0.9166666666666666 0.293309278750352 0.892786655765125 0.5930479672577385 0.599477377014773 0 0 0 0 K18013 0.0714285714285714 0.1196581196581196 kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 228.0 80.0 73.0 2.0 0.919540229885058 S 31.0 56.0 1.0 1.0 COG3246 Uncharacterized_conserved_protein,_DUF849_family 87.0 0.3563218390804598 0.6436781609195402 0.10680847151843 0.371981331501774 0.2393949015101019 0.265172859983344 0 0 0 0 K18014 0.0057142857142857 0.0854700854700854 kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 102.0 36.0 0.0 1.0 1.0 I 2.0 34.0 2.0 0.777777777777778 COG1607 Acyl-CoA_hydrolase YciA 36.0 0.0555555555555555 0.9444444444444444 0.0336988296318929 0.325586823365021 0.1796428264984569 0.291887993733128 0 0 0 0 K18015 0.0 0.0056980056980056 elaD, sseL; deubiquitinase [EC:3.4.22.-] path:map05132 Salmonella infection 15.0 5.0 0.0 1.0 1.0 O 0.0 5.0 1.0 1.0 COG5160 Protease,_Ulp1_family ULP1 5.0 0.0 1.0 0.009046475695361 4.14895873340023e-12 0.0045232378497549 0.009046475691212 0 0 0 0 K18016 0.0742857142857142 0.0028490028490028 mbhL; membrane-bound hydrogenase subunit alpha [EC:1.12.7.2] 360.0 32.0 0.0 1.0 1.0 C 31.0 1.0 2.0 0.75 COG3261 Ni,Fe-hydrogenase_III_large_subunit HycE2 32.0 0.96875 0.03125 0.96470682728349 0.988142847900972 0.976424837592231 0.0234360206174819 0 0 1 1 K18017 0.0685714285714285 0.0028490028490028 mbhK; membrane-bound hydrogenase subunit beta [EC:1.12.7.2] 130.0 29.0 0.0 1.0 1.0 C 28.0 1.0 1.0 1.0 COG3262 Ni,Fe-hydrogenase_III_component_G HycE1 29.0 0.9655172413793104 0.0344827586206896 0.803041013895411 0.689280698814393 0.746160856354902 0.113760315081018 0 0 1 1 K18020 0.0571428571428571 0.0 cutA; glyceraldehyde dehydrogenase large subunit [EC:1.2.99.8] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 676.0 37.0 0.0 1.0 1.0 C 37.0 0.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 37.0 1.0 0.0 0.662436569866795 0.916828995266501 0.789632782566648 0.2543924253997059 0 0 0 1 K18021 0.0314285714285714 0.0028490028490028 cutB; glyceraldehyde dehydrogenase medium subunit [EC:1.2.99.8] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 277.0 13.0 0.0 1.0 1.0 C 12.0 1.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 13.0 0.9230769230769232 0.0769230769230769 0.019413153942566 0.0228817011307535 0.0211474275366597 0.0034685471881874 0 0 0 0 K18022 0.0628571428571428 0.0 cutC; glyceraldehyde dehydrogenase small subunit [EC:1.2.99.8] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 152.0 30.0 0.0 1.0 1.0 C 30.0 0.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 30.0 1.0 0.0 0.0080416643795589 0.0171868873271253 0.0126142758533421 0.0091452229475664 0 0 0 0 K18023 0.0685714285714285 0.0085470085470085 mbhJ; membrane-bound hydrogenase subunit mbhJ [EC:1.12.7.2] 135.0 28.0 0.0 1.0 1.0 C 25.0 3.0 1.0 1.0 COG3260 Ni,Fe-hydrogenase_III_small_subunit HycG 28.0 0.8928571428571429 0.1071428571428571 0.946081671893144 0.983867124600379 0.9649743982467616 0.0377854527072349 0 0 1 1 K18028 0.0057142857142857 0.037037037037037 nicX; 2,5-dihydroxypyridine 5,6-dioxygenase [EC:1.13.11.9] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 315.0 18.0 0.0 1.0 1.0 E 2.0 16.0 1.0 1.0 COG2309 Leucyl_aminopeptidase_(aminopeptidase_T) AmpS 18.0 0.1111111111111111 0.8888888888888888 0.0343245433844849 0.575896382360007 0.3051104628722459 0.5415718389755221 0 0 0 0 K18029 0.0 0.0313390313390313 nicA; nicotinate dehydrogenase subunit A [EC:1.17.2.1] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 150.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 11.0 0.0 1.0 0.039748319339306 0.0661800353326811 0.0529641773359935 0.0264317159933751 0 0 0 0 K18030 0.0 0.0085470085470085 nicB; nicotinate dehydrogenase subunit B [EC:1.17.2.1] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 1118.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 3.0 0.0 1.0 0 0 0 0 K18031 0.0 0.0028490028490028 nspLOX; linolenate 9R-lipoxygenase [EC:1.13.11.61] 216.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG0753 Catalase KatE 1.0 0.0 1.0 0 0 0 0 K18045 0.0 0.0028490028490028 SIW14, OCA3; tyrosine-protein phosphatase SIW14 [EC:3.1.3.48] 236.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG2365 Protein_tyrosine/serine_phosphatase_Oca4 Oca4 1.0 0.0 1.0 0 0 0 0 K18049 0.0028571428571428 0.0 mpnS; methylphosphonate synthase [EC:1.13.11.73] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 457.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 1.0 1.0 0.0 0 0 0 0 K18055 0.0 0.0085470085470085 HIF1AN; hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) [EC:1.14.11.30] 233.0 2.0 1.0 3.0 0.5 S 0.0 4.0 1.0 1.0 COG2850 Ribosomal_protein_L16_Arg81_hydroxylase,_contains_JmjC_domain RoxA 4.0 0.0 1.0 0.0148198098035731 0.0341071305405889 0.024463470172081 0.0192873207370158 0 0 0 0 K18056 0.0 0.017094017094017 pntH, ptlH; 1-deoxypentalenic acid 11beta-hydroxylase [EC:1.14.11.35] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 242.0 14.0 0.0 1.0 1.0 Q 0.0 14.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 14.0 0.0 1.0 5.01221011417609e-15 1.03843229415106e-08 5.192163976860357e-09 1.0384317929300489e-08 0 0 0 0 K18058 0.0 0.0085470085470085 asnO; L-asparagine oxygenase [EC:1.14.11.39] 290.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 4.0 0.0 1.0 4.70999221621235e-08 2.03777996311334e-05 1.0212449776647762e-05 2.033069970897128e-05 0 0 0 0 K18067 0.0 0.0028490028490028 pht4; phthalate 4,5-cis-dihydrodiol dehydrogenase [EC:1.3.1.64] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 409.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 1.0 0.0 1.0 0 0 0 0 K18068 0.0 0.0056980056980056 pht3; phthalate 4,5-dioxygenase [EC:1.14.12.7] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 349.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 2.0 0.0 1.0 0 0 0 0 K18069 0.0 0.0056980056980056 pht2; phthalate 4,5-dioxygenase reductase component [EC:1.18.1.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 314.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 2.0 0.0 1.0 0 0 0 0 K18071 0.0 0.0056980056980056 mhpco; 2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase [EC:1.14.13.242] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 124.0 2.0 0.0 1.0 1.0 CH 0.0 2.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 2.0 0.0 1.0 0 0 0 0 K18073 0.0 0.0028490028490028 parR; two-component system, OmpR family, response regulator ParR path:map01501,path:map01503,path:map02020 beta-Lactam resistance,Cationic antimicrobial peptide (CAMP) resistance,Two-component system 231.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 1.0 0.0 1.0 0 0 0 0 K18074 0.0 0.0085470085470085 tphA2; terephthalate 1,2-dioxygenase oxygenase component alpha subunit [EC:1.14.12.15] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 404.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 3.0 0.0 1.0 0 0 0 0 K18075 0.0 0.0056980056980056 tphA3; terephthalate 1,2-dioxygenase oxygenase component beta subunit [EC:1.14.12.15] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 154.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 2.0 0.0 1.0 0 0 0 0 K18076 0.0 0.0142450142450142 tphB; 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase [EC:1.3.1.53] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 312.0 3.0 1.0 2.0 0.6 H 0.0 5.0 1.0 1.0 COG1995 4-hydroxy-L-threonine_phosphate_dehydrogenase_PdxA PdxA 5.0 0.0 1.0 0.0896970420065379 0.227850981866262 0.1587740119363999 0.138153939859724 0 0 0 0 K18077 0.0 0.0142450142450142 tphA1; terephthalate 1,2-dioxygenase reductase component [EC:1.18.1.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 85.0 5.0 0.0 1.0 1.0 C 0.0 5.0 2.0 0.6 COG0633 Ferredoxin Fdx 5.0 0.0 1.0 0.11351692881707 0.198740863658794 0.156128896237932 0.085223934841724 0 0 0 0 K18087 0.0028571428571428 0.0056980056980056 bphAc, bphA3, bphF; biphenyl 2,3-dioxygenase ferredoxin component path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 100.0 3.0 0.0 1.0 1.0 P 1.0 2.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18088 0.0 0.0028490028490028 bphAd, bphA4, bphG; biphenyl 2,3-dioxygenase ferredoxin reductase component [EC:1.18.1.3] path:map00621,path:map01100,path:map01120,path:map01220 Dioxin degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 409.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 1.0 0.0 1.0 0 0 0 0 K18089 0.0 0.0028490028490028 todB, tcbAc; benzene/toluene/chlorobenzene dioxygenase ferredoxin component path:map00361,path:map00362,path:map00623,path:map00625,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 106.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 1.0 0.0 1.0 0 0 0 0 K18090 0.0 0.0028490028490028 todA, tcbAd; benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-] path:map00361,path:map00362,path:map00623,path:map00625,path:map01100,path:map01120,path:map01220 Chlorocyclohexane and chlorobenzene degradation,Benzoate degradation,Toluene degradation,Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 409.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 1.0 0.0 1.0 0 0 0 0 K18091 0.0 0.0028490028490028 pntE, penE, ptlE; pentalenolactone D synthase [EC:1.14.13.170 1.14.13.171] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 537.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 1.0 0.0 1.0 0 0 0 0 K18092 0.0057142857142857 0.0142450142450142 etbD; 2-hydroxy-6-oxo-octa-2,4-dienoate hydrolase [EC:3.7.1.-] path:map00642,path:map01100,path:map01120,path:map01220 Ethylbenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 221.0 5.0 3.0 2.0 0.714285714285714 I 2.0 5.0 2.0 0.714285714285714 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 7.0 0.2857142857142857 0.7142857142857143 0.0087975261781031 0.0672109558453042 0.0380042410117036 0.0584134296672011 0 0 0 0 K18093 0.0 0.0142450142450142 oprD; imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-] path:map01501,path:map02020 beta-Lactam resistance,Two-component system 154.0 7.0 6.0 2.0 0.875 M 0.0 8.0 2.0 0.875 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 8.0 0.0 1.0 0.0127626904601852 0.0272292688525766 0.0199959796563809 0.0144665783923914 0 0 0 0 K18096 0.0 0.0028490028490028 bjaI, rpaI, braI, rhiI; acyl-homoserine lactone synthase [EC:2.3.1.228 2.3.1.229 2.3.1.-] path:map02024 Quorum sensing 223.0 1.0 0.0 1.0 1.0 QT 0.0 1.0 1.0 1.0 COG3916 N-acyl-homoserine_lactone_synthase_LasI_(autoinducer_biosynthesis) LasI 1.0 0.0 1.0 0 0 0 0 K18098 0.0 0.0227920227920227 bjaR1, rpaR, rhiR; LuxR family transcriptional regulator, quorum-sensing system regulator BjaR1 path:map02024 Quorum sensing 141.0 10.0 0.0 1.0 1.0 K 0.0 10.0 2.0 0.6 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 10.0 0.0 1.0 0.0272261401632544 0.0571513210865277 0.042188730624891 0.0299251809232733 0 0 0 0 K18099 0.0 0.0028490028490028 rhlR, phzR; LuxR family transcriptional regulator, quorum-sensing system regulator RhlR path:map02024,path:map02025 Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 245.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2771 DNA-binding_transcriptional_regulator,_CsgD_family CsgD 1.0 0.0 1.0 0 0 0 0 K18100 0.0 0.0028490028490028 rhlA; rhamnosyltransferase subunit A [EC:2.4.1.-] path:map02024,path:map02025 Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 272.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 1.0 0.0 1.0 0 0 0 0 K18101 0.0 0.0056980056980056 rhlB; rhamnosyltransferase subunit B [EC:2.4.1.-] path:map02024,path:map02025 Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 144.0 2.0 0.0 1.0 1.0 CG 0.0 2.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 2.0 0.0 1.0 0 0 0 0 K18104 0.0 0.0512820512820512 abcA, bmrA; ATP-binding cassette, subfamily B, bacterial AbcA/BmrA [EC:7.6.2.2] path:map01501,path:map02010 beta-Lactam resistance,ABC transporters 498.0 17.0 15.0 2.0 0.894736842105263 V 0.0 19.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 19.0 0.0 1.0 0.0199273809990202 0.0589917954815748 0.0394595882402975 0.0390644144825546 0 0 0 0 K18105 0.1685714285714285 0.0056980056980056 rtcA; RNA 3'-terminal phosphate cyclase (GTP) [EC:6.5.1.5] 274.0 56.0 51.0 2.0 0.918032786885246 J 59.0 2.0 1.0 1.0 COG0430 RNA_3'-terminal_phosphate_cyclase RCL1 61.0 0.9672131147540984 0.0327868852459016 0.992079151940566 0.979785189048186 0.985932170494376 0.0122939628923799 0 0 1 1 K18106 0.0028571428571428 0.0113960113960113 GAAA; D-galacturonate reductase [EC:1.1.1.-] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 415.0 5.0 0.0 1.0 1.0 S 1.0 4.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 5.0 0.2 0.8 0.0225093911759121 0.200850689749694 0.111680040462803 0.1783412985737819 0 0 0 0 K18109 0.0028571428571428 0.0085470085470085 np1; 5-epi-alpha-selinene synthase [EC:4.2.3.90] path:map00909 Sesquiterpenoid and triterpenoid biosynthesis 38.0 3.0 2.0 2.0 0.75 T 1.0 3.0 2.0 0.75 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 4.0 0.25 0.75 0.0319213727764121 0.0791841305028223 0.0555527516396172 0.0472627577264102 0 0 0 0 K18110 0.0 0.0056980056980056 tpc1; avermitilol synthase [EC:4.2.3.96] path:map00909 Sesquiterpenoid and triterpenoid biosynthesis 29.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K18111 0.0 0.0028490028490028 gcoA; (+)-beta-caryophyllene/(+)-caryolan-1-ol synthase [EC:4.2.3.89 4.2.1.138] path:map00909 Sesquiterpenoid and triterpenoid biosynthesis 338.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DVET 2.0 0.0 1.0 0 0 0 0 K18113 0.0028571428571428 0.0 MDS; miltiradiene synthase / copalyl diphosphate synthase [EC:4.2.3.131 5.5.1.12] path:map00904,path:map01100,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 489.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2CKJS 1.0 1.0 0.0 0 0 0 0 K18115 0.0 0.0085470085470085 sqhC; sporulenol synthase [EC:4.2.1.137] 598.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG1657 Terpene_cyclase_SqhC SqhC 3.0 0.0 1.0 0 0 0 0 K18118 0.0428571428571428 0.1538461538461538 aarC, cat1; succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] path:map00020,path:map00620,path:map00650,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Pyruvate metabolism,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 419.0 80.0 0.0 1.0 1.0 C 20.0 60.0 1.0 1.0 COG0427 Propionyl_CoA:succinate_CoA_transferase ACH1 80.0 0.25 0.75 0.0883385540929507 0.0778515651905949 0.0830950596417728 0.0104869889023558 0 0 0 0 K18119 0.0028571428571428 0.0142450142450142 sucD; succinate-semialdehyde dehydrogenase [EC:1.2.1.76] path:map00650,path:map01100,path:map01200 Butanoate metabolism,Metabolic pathways,Carbon metabolism 436.0 8.0 0.0 1.0 1.0 C 1.0 7.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 8.0 0.125 0.875 0.0556172241349449 0.0959633072381982 0.0757902656865715 0.0403460831032532 0 0 0 0 K18120 0.0 0.0341880341880341 4hbD, abfH; 4-hydroxybutyrate dehydrogenase [EC:1.1.1.61] path:map00650,path:map01100,path:map01200 Butanoate metabolism,Metabolic pathways,Carbon metabolism 330.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 12.0 0.0 1.0 0.0912993634905128 0.127703786436114 0.1095015749633133 0.0364044229456011 0 0 0 0 K18121 0.0028571428571428 0.0113960113960113 GLYR; glyoxylate/succinic semialdehyde reductase [EC:1.1.1.79 1.1.1.-] path:map00630,path:map00650,path:map01100,path:map01110,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Butanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 286.0 5.0 0.0 1.0 1.0 I 1.0 4.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 5.0 0.2 0.8 0.0159486048676064 0.07308209963641 0.0445153522520082 0.0571334947688036 0 0 0 0 K18122 0.0142857142857142 0.0512820512820512 cat2, abfT; 4-hydroxybutyrate CoA-transferase [EC:2.8.3.-] path:map00650,path:map01100,path:map01200 Butanoate metabolism,Metabolic pathways,Carbon metabolism 384.0 40.0 0.0 1.0 1.0 C 9.0 31.0 1.0 1.0 COG0427 Propionyl_CoA:succinate_CoA_transferase ACH1 40.0 0.225 0.775 0.0057018920537507 0.0243683207476417 0.0150351064006962 0.018666428693891 0 0 0 0 K18123 0.0 0.0113960113960113 HOGA1; 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16] path:map00330,path:map00630,path:map01100 Arginine and proline metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways 284.0 3.0 2.0 2.0 0.75 EM 0.0 4.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 4.0 0.0 1.0 3.47395341826542e-12 2.43861308123084e-08 1.2194802382863332e-08 2.438265685889013e-08 0 0 0 0 K18124 0.0485714285714285 0.0 gdh2, gdhA; glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360] path:map00030,path:map00052,path:map01100,path:map01110,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 331.0 16.0 11.0 2.0 0.761904761904762 E 21.0 0.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 21.0 1.0 0.0 0.0021698127725286 0.0023928506045735 0.002281331688551 0.0002230378320449 0 0 0 0 K18125 0.0571428571428571 0.0 ssgdh; aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359] path:map00030,path:map00052,path:map01100,path:map01110,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 304.0 19.0 10.0 2.0 0.678571428571429 E 28.0 0.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 28.0 1.0 0.0 0.0107926985664656 0.0155397177055108 0.0131662081359882 0.0047470191390452 0 0 0 0 K18126 0.0342857142857142 0.0 sskdgK; 2-dehydro-3-deoxygluconokinase / 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.178] path:map00030,path:map00052,path:map01100,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Carbon metabolism 295.0 13.0 0.0 1.0 1.0 G 13.0 0.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 13.0 1.0 0.0 0.624359971975257 0.63708658892661 0.6307232804509335 0.0127266169513529 0 0 0 1 K18127 0.0628571428571428 0.0 kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase [EC:4.1.2.51] path:map00030,path:map00052,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Galactose metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 267.0 18.0 13.0 2.0 0.782608695652174 E 23.0 0.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 23.0 1.0 0.0 0.0048634104871021 0.0132177631428559 0.009040586814979 0.0083543526557538 0 0 0 0 K18128 0.0514285714285714 0.0 gadh; D-glyceraldehyde dehydrogenase (NADP+) [EC:1.2.1.89] path:map00030,path:map01100,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 476.0 20.0 0.0 1.0 1.0 C 20.0 0.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 20.0 1.0 0.0 0.0222814689998199 0.0244514723855632 0.0233664706926915 0.0021700033857433 0 0 0 0 K18129 0.0 0.0028490028490028 mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor path:map01501 beta-Lactam resistance 187.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K18130 0.0 0.0028490028490028 nalC; TetR/AcrR family transcriptional regulator, transcriptional repressor NalC path:map01501 beta-Lactam resistance 213.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K18133 0.0 0.0056980056980056 K18133, porB; major outer membrane protein P.IB path:map01501 beta-Lactam resistance 337.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG3203 Outer_membrane_porin_OmpC/OmpF/PhoE OmpC 5.0 0.0 1.0 4.34847315596824e-06 3.68550930738064e-14 2.1742365964116665e-06 4.348473119113147e-06 0 0 0 0 K18135 0.0 0.0142450142450142 nalD; TetR/AcrR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon path:map01501 beta-Lactam resistance 196.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 5.0 0.0 1.0 0.0658929747966209 0.18396204625664 0.1249275105266304 0.1180690714600191 0 0 0 0 K18136 0.0 0.0113960113960113 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor path:map01501 beta-Lactam resistance 178.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 4.0 0.0 1.0 0.0367082255512358 0.0815474580445565 0.0591278417978961 0.0448392324933207 0 0 0 0 K18138 0.0 0.301994301994302 acrB, mexB, adeJ, smeE, mtrD, cmeB; multidrug efflux pump path:map01501,path:map01503 beta-Lactam resistance,Cationic antimicrobial peptide (CAMP) resistance 773.0 171.0 146.0 3.0 0.868020304568528 V 0.0 197.0 2.0 0.99492385786802 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 197.0 0.0 1.0 0.0006984312748697 0.0085874977239313 0.0046429644994004 0.0078890664490616 0 0 0 0 K18139 0.0 0.168091168091168 oprM, emhC, ttgC, cusC, adeK, smeF, mtrE, cmeC, gesC; outer membrane protein, multidrug efflux system path:map01501,path:map02024 beta-Lactam resistance,Quorum sensing 364.0 46.0 2.0 2.0 0.511111111111111 M 0.0 90.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 90.0 0.0 1.0 0.0056571193867257 0.026477261507809 0.0160671904472673 0.0208201421210833 0 0 0 0 K18140 0.0 0.0056980056980056 envR, acrS; TetR/AcrR family transcriptional regulator, acrEF/envCD operon repressor 178.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 2.0 0.0 1.0 0 0 0 0 K18141 0.0 0.0056980056980056 acrE; membrane fusion protein, multidrug efflux system 385.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 3.0 0.0 1.0 0 0 0 0 K18142 0.0 0.0056980056980056 acrF; multidrug efflux pump 1029.0 2.0 1.0 2.0 0.666666666666667 V 0.0 3.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 3.0 0.0 1.0 0 0 0 0 K18143 0.0 0.0398860398860398 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3] path:map01501 beta-Lactam resistance 300.0 15.0 0.0 1.0 1.0 T 0.0 15.0 3.0 0.666666666666667 COG0642 Signal_transduction_histidine_kinase BaeS 15.0 0.0 1.0 0.0626080307054342 0.0437462090646659 0.05317711988505 0.0188618216407683 0 0 0 0 K18144 0.0028571428571428 0.0455840455840455 adeR; two-component system, OmpR family, response regulator AdeR path:map01501 beta-Lactam resistance 210.0 8.0 2.0 3.0 0.421052631578947 K 1.0 18.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 19.0 0.0526315789473684 0.9473684210526316 0.0312900615285864 0.107521182391624 0.0694056219601052 0.0762311208630376 0 0 0 0 K18145 0.0 0.0142450142450142 adeA; membrane fusion protein, multidrug efflux system path:map01501 beta-Lactam resistance 373.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 5.0 0.0 1.0 0.039851867133042 0.0784524174126214 0.0591521422728317 0.0386005502795794 0 0 0 0 K18146 0.0 0.0085470085470085 adeB; multidrug efflux pump path:map01501 beta-Lactam resistance 1030.0 2.0 1.0 2.0 0.666666666666667 U 0.0 3.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 3.0 0.0 1.0 0 0 0 0 K18148 0.0371428571428571 0.037037037037037 rtcB; release factor H-coupled RctB family protein path:map01501 beta-Lactam resistance 235.0 30.0 29.0 2.0 0.967741935483871 S 15.0 16.0 1.0 1.0 COG1690 RNA-splicing_ligase_RtcB,_repairs_tRNA_damage RtcB 31.0 0.4838709677419355 0.5161290322580645 0.721874614738999 0.016137746306347 0.369006180522673 0.705736868432652 0 1 0 1 K18149 0.0 0.0056980056980056 pbp5, pbp4, pbp3; penicillin-binding protein path:map00550,path:map01100,path:map01501 Peptidoglycan biosynthesis,Metabolic pathways,beta-Lactam resistance 651.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 2.0 0.0 1.0 0 0 0 0 K18151 0.0 0.017094017094017 UAH; ureidoglycolate amidohydrolase [EC:3.5.1.116] path:map00230,path:map01100,path:map01120 Purine metabolism,Metabolic pathways,Microbial metabolism in diverse environments 398.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 8.0 0.0 1.0 1.87667869936761e-05 1.00275507714584e-11 9.383398510613436e-06 1.8766776966125328e-05 0 0 0 0 K18158 0.0114285714285714 0.0 NCA2; nuclear control of ATPase protein 2 142.0 8.0 0.0 1.0 1.0 U 8.0 0.0 1.0 1.0 KOG0078 8.0 1.0 0.0 0.602767276694306 0.0241713862753 0.313469331484803 0.5785958904190059 0 0 0 1 K18163 0.0114285714285714 0.0427350427350427 NDUFAF6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 6 path:map04714 Thermogenesis 189.0 20.0 0.0 1.0 1.0 I 4.0 16.0 2.0 0.95 COG1562 Phytoene/squalene_synthetase ERG9 20.0 0.2 0.8 0.0005060338308838 0.0021819324413395 0.0013439831361116 0.0016758986104556 0 0 0 0 K18164 0.0028571428571428 0.0626780626780626 NDUFAF7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 7 path:map04714 Thermogenesis 270.0 14.0 6.0 3.0 0.608695652173913 S 1.0 22.0 2.0 0.956521739130435 COG1565 SAM-dependent_methyltransferase,_MidA_family MidA 23.0 0.0434782608695652 0.9565217391304348 0.0049702049466251 0.0096584230147484 0.0073143139806867 0.0046882180681233 0 0 0 0 K18177 0.0057142857142857 0.0 COA4; cytochrome c oxidase assembly factor 4 path:map04714 Thermogenesis 122.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 COG1990 Peptidyl-tRNA_hydrolase Pth2 2.0 1.0 0.0 0 0 0 0 K18195 0.0028571428571428 0.0284900284900284 RGL4, rhiE; rhamnogalacturonan endolyase [EC:4.2.2.23] 263.0 36.0 35.0 3.0 0.947368421052632 T 1.0 37.0 4.0 0.815789473684211 COG1506 Dipeptidyl_aminopeptidase/acylaminoacyl_peptidase DAP2 38.0 0.0263157894736842 0.9736842105263158 3.46660960640995e-13 0.0008167307021067 0.0004083653512266 0.00081673070176 0 0 0 0 K18197 0.0028571428571428 0.0854700854700854 yesW; rhamnogalacturonan endolyase [EC:4.2.2.23] 78.0 11.0 2.0 7.0 0.314285714285714 S 1.0 34.0 13.0 0.285714285714286 COG1649 Uncharacterized_lipoprotein_YddW,_UPF0748_family YddW 35.0 0.0285714285714285 0.9714285714285714 0.0258364253202223 0.159506824081424 0.0926716247008231 0.1336703987612017 0 0 0 0 K18198 0.0 0.0056980056980056 yesX; rhamnogalacturonan exolyase [EC:4.2.2.24] 582.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 2.0 0.666666666666667 COG1649 Uncharacterized_lipoprotein_YddW,_UPF0748_family YddW 3.0 0.0 1.0 0 0 0 0 K18199 0.0028571428571428 0.0598290598290598 inhA; cyclohexyl-isocyanide hydratase [EC:4.2.1.103] path:map00930,path:map01120 Caprolactam degradation,Microbial metabolism in diverse environments 143.0 21.0 16.0 2.0 0.807692307692308 S 1.0 25.0 3.0 0.884615384615385 COG0693 Protein/nucleotide_deglycase,_PfpI/YajL/DJ-1_family_(repair_of_methylglyoxal-glycated_proteins_and_nucleic_acids) YajL 26.0 0.0384615384615384 0.9615384615384616 0.0256621069075747 0.0734579606233952 0.0495600337654849 0.0477958537158205 0 0 0 0 K18202 0.0 0.0028490028490028 AGXT2L2; 5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134] path:map00310,path:map01100 Lysine degradation,Metabolic pathways 429.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 1.0 0.0 1.0 0 0 0 0 K18205 0.0 0.0028490028490028 hypBA1; non-reducing end beta-L-arabinofuranosidase [EC:3.2.1.185] 640.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3533 Beta-L-arabinofuranosidase,_GH127_family HybA1 1.0 0.0 1.0 0 0 0 0 K18206 0.0 0.0113960113960113 hypBA2; beta-L-arabinobiosidase [EC:3.2.1.187] 412.0 3.0 2.0 2.0 0.75 G 0.0 4.0 2.0 0.75 COG3408 Glycogen_debranching_enzyme_(alpha-1,6-glucosidase) GDB1 4.0 0.0 1.0 0.128851935624746 0.241359882879769 0.1851059092522575 0.112507947255023 0 0 0 0 K18209 0.12 0.0142450142450142 tfrA; fumarate reductase (CoM/CoB) subunit A [EC:1.3.4.1] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 397.0 53.0 0.0 1.0 1.0 C 48.0 5.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 53.0 0.9056603773584906 0.0943396226415094 0.325203207077087 0.0827439823764477 0.2039735947267673 0.2424592247006393 0 0 0 0 K18210 0.0971428571428571 0.0 tfrB; fumarate reductase (CoM/CoB) subunit B [EC:1.3.4.1] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 320.0 41.0 0.0 1.0 1.0 C 41.0 0.0 2.0 0.634146341463415 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 41.0 1.0 0.0 0.0051226500189827 0.0231123983982945 0.0141175242086386 0.0179897483793118 0 0 0 0 K18214 0.02 0.017094017094017 tetP_A, tet40; MFS transporter, DHA3 family, tetracycline resistance protein 344.0 13.0 0.0 1.0 1.0 G 7.0 6.0 1.0 1.0 COG0738 Fucose_permease FucP 13.0 0.5384615384615384 0.4615384615384615 0.830625514274698 0.162079184218711 0.4963523492467045 0.668546330055987 1 1 1 1 K18215 0.0028571428571428 0.0028490028490028 tetV; MFS transporter, DHA3 family, tetracycline resistance protein 388.0 2.0 0.0 1.0 1.0 EGP 1.0 1.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 2.0 0.5 0.5 0 0 0 0 K18216 0.0 0.0313390313390313 steA, tetA46; ATP-binding cassette, subfamily B, tetracycline resistant protein path:map02010 ABC transporters 575.0 11.0 0.0 1.0 1.0 V 0.0 11.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 11.0 0.0 1.0 0.0136863040338727 0.0163848683836629 0.0150355862087678 0.0026985643497902 0 0 0 0 K18217 0.0 0.037037037037037 steB, tetB46; ATP-binding cassette, subfamily B, tetracycline resistant protein path:map02010 ABC transporters 550.0 13.0 0.0 1.0 1.0 V 0.0 13.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 13.0 0.0 1.0 0.0159763278196636 0.0341427521715174 0.0250595399955905 0.0181664243518538 0 0 0 0 K18218 0.0 0.0085470085470085 tet35; tetracycline resistance efflux pump 95.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1757 Na+/H+_antiporter_NhaC/MleN NhaC 3.0 0.0 1.0 0 0 0 0 K18219 0.0 0.0028490028490028 txr; sigma-54 dependent transcriptional regulator, tetracycline resistant transcriptional regulator 464.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 1.0 0.0 1.0 0 0 0 0 K18220 0.0 0.0427350427350427 tetM, tetO; ribosomal protection tetracycline resistance protein 567.0 18.0 0.0 1.0 1.0 J 0.0 18.0 1.0 1.0 COG0480 Translation_elongation_factor_EF-G,_a_GTPase FusA 18.0 0.0 1.0 0.307551911775382 0.360141809249807 0.3338468605125945 0.0525898974744249 0 0 0 0 K18221 0.0 0.0028490028490028 tetX; tetracycline 11a-monooxygenase, tetracycline resistance protein [EC:1.14.13.231] path:map00253,path:map01110 Tetracycline biosynthesis,Biosynthesis of secondary metabolites 377.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K18223 0.0 0.0455840455840455 prmA; propane 2-monooxygenase large subunit [EC:1.14.13.227] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 77.0 9.0 5.0 3.0 0.5625 T 0.0 16.0 2.0 0.75 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 16.0 0.0 1.0 0.0173781371289464 0.0509171524168435 0.0341476447728949 0.0335390152878971 0 0 0 0 K18224 0.0 0.017094017094017 prmC; propane 2-monooxygenase small subunit [EC:1.14.13.227] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 349.0 5.0 4.0 2.0 0.833333333333333 S 0.0 6.0 1.0 1.0 2DB9W 6.0 0.0 1.0 0.0304313026587082 0.0264776146591146 0.0284544586589114 0.0039536879995936 0 0 0 0 K18225 0.0085714285714285 0.0398860398860398 prmB; propane monooxygenase reductase component [EC:1.18.1.-] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 192.0 19.0 0.0 1.0 1.0 C 4.0 15.0 4.0 0.368421052631579 COG0543 NAD(P)H-flavin_reductase Mcr1 19.0 0.2105263157894736 0.7894736842105263 0.0490916375614245 0.0714557340826353 0.0602736858220298 0.0223640965212107 0 0 0 0 K18226 0.0 0.0142450142450142 prmD; propane monooxygenase coupling protein path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 115.0 3.0 1.0 2.0 0.6 Q 0.0 5.0 1.0 1.0 2AAX9 5.0 0.0 1.0 0.0098985934674622 0.0120321589561629 0.0109653762118125 0.0021335654887007 0 0 0 0 K18227 0.0 0.0028490028490028 cmtAa; p-cumate 2,3-dioxygenase ferredoxin reductase component [EC:1.18.1.3] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 400.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 1.0 0.0 1.0 0 0 0 0 K18229 0.0 0.0085470085470085 PAMO; phenylacetone monooxygenase [EC:1.14.13.92] 528.0 3.0 0.0 1.0 1.0 P 0.0 3.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 3.0 0.0 1.0 0 0 0 0 K18230 0.0 0.0541310541310541 tylC, oleB, carA, srmB; macrolide transport system ATP-binding/permease protein path:map02010 ABC transporters 475.0 22.0 21.0 2.0 0.956521739130435 S 0.0 23.0 1.0 1.0 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 23.0 0.0 1.0 0.0125215658267123 0.0336195598134465 0.0230705628200794 0.0210979939867341 0 0 0 0 K18231 0.0 0.0455840455840455 msr, vmlR; macrolide transport system ATP-binding/permease protein path:map02010 ABC transporters 445.0 17.0 15.0 2.0 0.894736842105263 S 0.0 19.0 1.0 1.0 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 19.0 0.0 1.0 0.0088398551454886 0.0182925452455063 0.0135662001954974 0.0094526901000177 0 0 0 0 K18232 0.0057142857142857 0.0313390313390313 oleC4; oleandomycin transport system ATP-binding protein path:map02010 ABC transporters 308.0 14.0 0.0 1.0 1.0 V 2.0 12.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 14.0 0.1428571428571428 0.8571428571428571 0.0111940439755518 0.0448730350760855 0.0280335395258186 0.0336789911005337 0 0 0 0 K18233 0.0057142857142857 0.0541310541310541 oleC5; oleandomycin transport system permease protein path:map02010 ABC transporters 237.0 31.0 0.0 1.0 1.0 V 2.0 29.0 1.0 1.0 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 31.0 0.064516129032258 0.935483870967742 0.007161590883252 0.0588365687898689 0.0329990798365604 0.0516749779066169 0 0 0 0 K18234 0.0 0.0911680911680911 vat; virginiamycin A acetyltransferase [EC:2.3.1.-] 134.0 32.0 28.0 3.0 0.842105263157895 S 0.0 38.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 38.0 0.0 1.0 0.0755690383031285 0.39897735345878 0.2372731958809542 0.3234083151556515 0 0 0 0 K18235 0.0314285714285714 0.0199430199430199 vgb; virginiamycin B lyase [EC:4.2.99.-] 268.0 24.0 0.0 1.0 1.0 V 17.0 7.0 1.0 1.0 COG4257 Streptogramin_lyase Vgb 24.0 0.7083333333333334 0.2916666666666667 0.0100379970652136 0.059893316809979 0.0349656569375963 0.0498553197447654 0 0 0 0 K18236 0.0028571428571428 0.0142450142450142 lnuB_F, lin; lincosamide nucleotidyltransferase B/F 213.0 6.0 0.0 1.0 1.0 S 1.0 5.0 1.0 1.0 COG1708 Predicted_nucleotidyltransferase,_MJ0604_family MJ0604 6.0 0.1666666666666666 0.8333333333333334 0.0387358429700553 0.0988184606701771 0.0687771518201162 0.0600826177001218 0 0 0 0 K18237 0.48 0.0028490028490028 K18237; ribose 1,5-bisphosphate isomerase [EC:5.3.1.29] 222.0 182.0 0.0 1.0 1.0 J 181.0 1.0 1.0 1.0 COG1184 Translation_initiation_factor_2B_subunit,_eIF-2B_alpha/beta/delta_family GCD2 182.0 0.9945054945054944 0.0054945054945054 0.946965405830717 0.931194013043122 0.9390797094369194 0.0157713927875949 0 0 1 1 K18239 0.0 0.0028490028490028 fkbO, rapK; chorismatase [EC:3.3.2.13] path:map00400 Phenylalanine, tyrosine and tryptophan biosynthesis 339.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0251 Enamine_deaminase_RidA,_house_cleaning_of_reactive_enamine_intermediates,_YjgF/YER057c/UK114_family RidA 1.0 0.0 1.0 0 0 0 0 K18240 0.0 0.0085470085470085 xanB2; chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45] path:map00130,path:map00400,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 239.0 3.0 0.0 1.0 1.0 J 0.0 3.0 1.0 1.0 COG0251 Enamine_deaminase_RidA,_house_cleaning_of_reactive_enamine_intermediates,_YjgF/YER057c/UK114_family RidA 3.0 0.0 1.0 0 0 0 0 K18242 0.0 0.0056980056980056 nagG; salicylate 5-hydroxylase large subunit [EC:1.14.13.172] path:map00626,path:map01100,path:map01120 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments 409.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 2.0 0.0 1.0 0 0 0 0 K18243 0.0 0.0028490028490028 nagH; salicylate 5-hydroxylase small subunit [EC:1.14.13.172] path:map00626,path:map01100,path:map01120 Naphthalene degradation,Metabolic pathways,Microbial metabolism in diverse environments 156.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 1.0 0.0 1.0 0 0 0 0 K18244 0.1171428571428571 0.094017094017094 mmgC; acyl-CoA dehydrogenase [EC:1.3.99.-] 309.0 86.0 72.0 2.0 0.86 I 59.0 41.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 100.0 0.59 0.41 0.135167750774387 0.966785116894537 0.550976433834462 0.83161736612015 0 0 0 0 K18248 0.0085714285714285 0.0199430199430199 andAb; anthranilate 1,2-dioxygenase ferredoxin component path:map00627,path:map01100,path:map01120 Aminobenzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 69.0 8.0 6.0 2.0 0.8 P 3.0 7.0 2.0 0.8 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 10.0 0.3 0.7 0.0735645022882357 0.19147329612105 0.1325188992046428 0.1179087938328142 0 0 0 0 K18251 0.0 0.0028490028490028 phtAa; phthalate 3,4-dioxygenase subunit alpha [EC:1.14.12.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 467.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 1.0 0.0 1.0 0 0 0 0 K18252 0.0 0.0056980056980056 phtAb; phthalate 3,4-dioxygenase subunit beta [EC:1.14.12.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 165.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG5517 3-phenylpropionate/cinnamic_acid_dioxygenase,_small_subunit HcaF 2.0 0.0 1.0 0 0 0 0 K18253 0.0028571428571428 0.0028490028490028 phtAc; phthalate 3,4-dioxygenase ferredoxin component path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 53.0 3.0 0.0 1.0 1.0 C 1.0 2.0 1.0 1.0 COG1141 Ferredoxin Fer 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18254 0.0 0.0028490028490028 phtAd; phthalate 3,4-dioxygenase ferredoxin reductase component [EC:1.18.1.3] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 412.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 1.0 0.0 1.0 0 0 0 0 K18255 0.0 0.0056980056980056 phtB; phthalate 3,4-cis-dihydrodiol dehydrogenase [EC:1.3.1.-] path:map00624,path:map01100,path:map01120,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 269.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K18256 0.0 0.0028490028490028 phtC; 3,4-dihydroxyphthalate decarboxylase [EC:4.1.1.69] path:map00624,path:map01100,path:map01120 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments 239.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 1.0 0.0 1.0 0 0 0 0 K18257 0.0 0.0028490028490028 phdE; cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase [EC:1.3.1.49] path:map00624,path:map01100,path:map01220 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Degradation of aromatic compounds 276.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K18258 0.0 0.0056980056980056 CRYM; thiomorpholine-carboxylate dehydrogenase [EC:1.5.1.25] 307.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 2.0 0.0 1.0 0 0 0 0 K18277 0.0 0.0512820512820512 tmm; trimethylamine monooxygenase [EC:1.14.13.148] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 436.0 13.0 8.0 2.0 0.722222222222222 P 0.0 18.0 1.0 1.0 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 18.0 0.0 1.0 0.0416689530480872 0.125093513183642 0.0833812331158646 0.0834245601355548 0 0 0 0 K18282 0.0 0.0028490028490028 cynD; cyanide dihydratase [EC:3.5.5.-] path:map00460,path:map01100 Cyanoamino acid metabolism,Metabolic pathways 342.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 1.0 0.0 1.0 0 0 0 0 K18284 0.0 0.0199430199430199 K18284; adenosylhomocysteine/aminodeoxyfutalosine nucleosidase [EC:3.2.2.9 3.2.2.30] path:map00130,path:map00270,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Cysteine and methionine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 228.0 7.0 0.0 1.0 1.0 E 0.0 7.0 1.0 1.0 COG0775 Nucleoside_phosphorylase/nucleosidase,_includes_5'-methylthioadenosine/S-adenosylhomocysteine_nucleosidase_MtnN_and_futalosine_hydrolase_MqnB MtnN 7.0 0.0 1.0 0.0083470398927706 0.0200074366369713 0.0141772382648709 0.0116603967442007 0 0 0 0 K18285 0.1142857142857142 0.2165242165242165 mqnE; aminodeoxyfutalosine synthase [EC:2.5.1.120] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 292.0 138.0 0.0 1.0 1.0 H 46.0 92.0 1.0 1.0 COG1060 2-iminoacetate_synthase_ThiH/Menaquinone_biosynthesis_enzymes_MqnC_and_MqnE ThiH 138.0 0.3333333333333333 0.6666666666666666 0.0184113364812626 0.446589929217524 0.2325006328493933 0.4281785927362614 0 0 0 0 K18286 0.0028571428571428 0.0569800569800569 add; aminodeoxyfutalosine deaminase [EC:3.5.4.40] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 301.0 27.0 0.0 1.0 1.0 F 1.0 26.0 1.0 1.0 COG1816 Adenosine_deaminase Add 27.0 0.037037037037037 0.9629629629629628 0.0438873971341011 0.190496980381808 0.1171921887579545 0.1466095832477069 0 0 0 0 K18287 0.0 0.0085470085470085 griI; 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase [EC:4.1.2.56] path:map00997,path:map01100,path:map01110 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 251.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG1830 Fructose-bisphosphate_aldolase_class_Ia,_DhnA_family FbaB 4.0 0.0 1.0 7.52643996535061e-12 0.123076790745112 0.0615383953763192 0.1230767907375855 0 0 0 0 K18288 0.0257142857142857 0.017094017094017 ict-Y; itaconate CoA-transferase [EC:2.8.3.-] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 380.0 19.0 0.0 1.0 1.0 C 12.0 7.0 1.0 1.0 COG0427 Propionyl_CoA:succinate_CoA_transferase ACH1 19.0 0.631578947368421 0.3684210526315789 0.0288923930128914 0.0466123318088652 0.0377523624108783 0.0177199387959738 0 0 0 0 K18289 0.0 0.0085470085470085 ict-P; itaconate CoA-transferase [EC:2.8.3.- 2.8.3.22] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 367.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 3.0 0.0 1.0 0 0 0 0 K18290 0.0 0.017094017094017 ich-Y; itaconyl-CoA hydratase [EC:4.2.1.56] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 165.0 6.0 0.0 1.0 1.0 I 0.0 6.0 1.0 1.0 COG2030 Acyl-CoA_dehydratase_PaaZ MaoC 6.0 0.0 1.0 0.0511797110223094 0.094915670465598 0.0730476907439537 0.0437359594432886 0 0 0 0 K18291 0.0 0.0256410256410256 ich-P; itaconyl-CoA hydratase / mesaconyl-C4 CoA hydratase [EC:4.2.1.56 4.2.1.-] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 275.0 12.0 0.0 1.0 1.0 S 0.0 12.0 1.0 1.0 COG3777 Hydroxyacyl-ACP_dehydratase_HTD2,_hotdog_domain HTD2 12.0 0.0 1.0 0.0213093687171447 0.053509597253569 0.0374094829853568 0.0322002285364243 0 0 0 0 K18292 0.0085714285714285 0.0569800569800569 E4.1.3.25; (S)-citramalyl-CoA lyase [EC:4.1.3.25] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 213.0 21.0 18.0 3.0 0.807692307692308 G 3.0 23.0 2.0 0.884615384615385 COG2301 Citrate_lyase_beta_subunit CitE 26.0 0.1153846153846153 0.8846153846153846 0.331218950911482 0.195639059223695 0.2634290050675885 0.135579891687787 0 0 0 0 K18293 0.0 0.0056980056980056 cymAb; p-cymene methyl-monooxygenase electron transfer component [EC:1.18.1.3] path:map00622,path:map01100,path:map01120,path:map01220 Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 188.0 2.0 0.0 1.0 1.0 C 0.0 2.0 2.0 0.5 COG0633 Ferredoxin Fdx 2.0 0.0 1.0 0 0 0 0 K18294 0.0 0.0056980056980056 nfxB; TetR/AcrR family transcriptional regulator, mexCD-oprJ operon repressor 177.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 2.0 0.0 1.0 0 0 0 0 K18295 0.0 0.0113960113960113 mexC; membrane fusion protein, multidrug efflux system 371.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 4.0 0.0 1.0 0.0749608067779785 0.1544421200312 0.1147014634045892 0.0794813132532215 0 0 0 0 K18296 0.0 0.0085470085470085 mexD; multidrug efflux pump 1035.0 2.0 1.0 2.0 0.666666666666667 V 0.0 3.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 3.0 0.0 1.0 0 0 0 0 K18297 0.0 0.0085470085470085 mexT; LysR family transcriptional regulator, mexEF-oprN operon transcriptional activator 283.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 3.0 0.0 1.0 0 0 0 0 K18298 0.0 0.017094017094017 mexE; membrane fusion protein, multidrug efflux system 317.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 7.0 0.0 1.0 0.0205175495644344 0.0401406784003742 0.0303291139824043 0.0196231288359397 0 0 0 0 K18299 0.0 0.0427350427350427 mexF; multidrug efflux pump 1013.0 18.0 15.0 2.0 0.857142857142857 V 0.0 21.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 21.0 0.0 1.0 0.0092469414626632 0.0231906829717876 0.0162188122172254 0.0139437415091244 0 0 0 0 K18300 0.0 0.0341880341880341 oprN; outer membrane protein, multidrug efflux system 425.0 10.0 8.0 2.0 0.833333333333333 MU 0.0 12.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 12.0 0.0 1.0 0.0656178492851748 0.139826071189195 0.1027219602371849 0.0742082219040201 0 0 0 0 K18301 0.0 0.0512820512820512 mexL; TetR/AcrR family transcriptional regulator, mexJK operon transcriptional repressor 134.0 20.0 0.0 1.0 1.0 K 0.0 20.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 20.0 0.0 1.0 0.0149695710959816 0.030704663486456 0.0228371172912188 0.0157350923904744 0 0 0 0 K18302 0.0 0.0227920227920227 mexJ; membrane fusion protein, multidrug efflux system 324.0 12.0 0.0 1.0 1.0 M 0.0 12.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 12.0 0.0 1.0 0.0079752006760558 0.0197266362056969 0.0138509184408763 0.0117514355296411 0 0 0 0 K18303 0.0 0.0341880341880341 mexK; multidrug efflux pump 1003.0 14.0 0.0 1.0 1.0 V 0.0 14.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 14.0 0.0 1.0 0.0196930775162899 0.0285889778959175 0.0241410277061037 0.0088959003796276 0 0 0 0 K18304 0.0 0.0028490028490028 lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR path:map02024,path:map02025 Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 150.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 1.0 0.0 1.0 0 0 0 0 K18305 0.0 0.0056980056980056 mexG; transmembrane protein 134.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG2259 Uncharacterized_membrane_protein_YphA,_DoxX/SURF4_family DoxX 2.0 0.0 1.0 0 0 0 0 K18306 0.0 0.0142450142450142 mexH; membrane fusion protein, multidrug efflux system path:map02024 Quorum sensing 292.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 5.0 0.0 1.0 0.0313487021961311 0.0613888019203077 0.0463687520582194 0.0300400997241766 0 0 0 0 K18307 0.0 0.017094017094017 mexI; multidrug efflux pump path:map02024 Quorum sensing 1013.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 6.0 0.0 1.0 0.0762778699726234 0.119958115409033 0.0981179926908282 0.0436802454364096 0 0 0 0 K18308 0.0 0.0056980056980056 opmD; outer membrane protein, multidrug efflux system 479.0 1.0 0.0 2.0 0.5 MU 0.0 2.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 2.0 0.0 1.0 0 0 0 0 K18310 0.02 0.0085470085470085 RIMKLB, NAAGS-I; beta-citrylglutamate/N-acetylaspartylglutamate synthase [EC:6.3.1.17 6.3.2.41] path:map00250,path:map01100 Alanine, aspartate and glutamate metabolism,Metabolic pathways 265.0 11.0 0.0 1.0 1.0 HJ 7.0 4.0 1.0 1.0 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 11.0 0.6363636363636364 0.3636363636363636 0.749673569443589 0.98835378282845 0.8690136761360194 0.238680213384861 0 0 0 1 K18313 0.0 0.0142450142450142 sct; succinyl-CoA---D-citramalate CoA-transferase [EC:2.8.3.20] 402.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 6.0 0.0 1.0 0.0395623706434258 0.177947611007476 0.1087549908254509 0.1383852403640502 0 0 0 0 K18314 0.0 0.0142450142450142 E4.1.3.46, ccl; (R)-citramalyl-CoA lyase [EC:4.1.3.46] 302.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 5.0 0.0 1.0 0.0566409982841664 0.2175888880694 0.1371149431767832 0.1609478897852336 0 0 0 0 K18316 0.0 0.0085470085470085 cpmA, carA; carbapenam-3-carboxylate synthase [EC:6.3.3.6] path:map00332,path:map01100,path:map01110,path:map02024 Carbapenem biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 53.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0367 Asparagine_synthetase_B_(glutamine-hydrolyzing) AsnB 3.0 0.0 1.0 0 0 0 0 K18320 0.0057142857142857 0.0142450142450142 IS15, IS26; transposase, IS6 family 177.0 11.0 0.0 1.0 1.0 L 3.0 10.0 1.0 1.0 COG3316 Transposase_(or_an_inactivated_derivative),_DDE_domain Rve 13.0 0.2307692307692307 0.7692307692307693 0.0398734087557034 0.0669447432059671 0.0534090759808352 0.0270713344502637 0 0 0 0 K18324 0.0 0.0056980056980056 acrD; multidrug efflux pump path:map02020 Two-component system 1037.0 1.0 0.0 2.0 0.5 U 0.0 2.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 2.0 0.0 1.0 0 0 0 0 K18325 0.0 0.0085470085470085 ramA; AraC family of transcriptional regulator, multidrug resistance transcriptional activator 89.0 3.0 0.0 1.0 1.0 K 0.0 3.0 2.0 0.666666666666667 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 3.0 0.0 1.0 0 0 0 0 K18326 0.0028571428571428 0.0056980056980056 mdtD; MFS transporter, DHA2 family, multidrug resistance protein path:map02020 Two-component system 99.0 3.0 0.0 1.0 1.0 EGP 1.0 2.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18330 0.0057142857142857 0.1111111111111111 hndA; NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3] 139.0 48.0 0.0 1.0 1.0 C 2.0 46.0 2.0 0.979166666666667 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 48.0 0.0416666666666666 0.9583333333333334 0.734096433629577 0.840575830436492 0.7873361320330345 0.1064793968069149 0 0 0 1 K18331 0.0857142857142857 0.2108262108262108 hndC; NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3] 420.0 149.0 0.0 1.0 1.0 C 37.0 112.0 2.0 0.946308724832215 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 149.0 0.2483221476510067 0.7516778523489933 0.939595305289264 0.90178778533382 0.920691545311542 0.037807519955444 1 1 1 1 K18332 0.0428571428571428 0.150997150997151 hndD; NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3] 488.0 94.0 0.0 1.0 1.0 C 16.0 78.0 3.0 0.893617021276596 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 94.0 0.1702127659574468 0.8297872340425532 0.812382909439348 0.963129221882776 0.887756065661062 0.150746312443428 1 1 1 1 K18333 0.0 0.0455840455840455 K18333; L-fucose dehydrogenase path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 256.0 18.0 16.0 2.0 0.9 IQ 0.0 20.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 20.0 0.0 1.0 0.0016083616583116 0.0056870381006278 0.0036476998794697 0.0040786764423161 0 0 0 0 K18334 0.0 0.0712250712250712 fucD; L-fuconate dehydratase [EC:4.2.1.68] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 427.0 30.0 0.0 1.0 1.0 M 0.0 30.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 30.0 0.0 1.0 0.0078193217820421 0.426345208705312 0.217082265243677 0.4185258869232699 0 0 0 0 K18335 0.0028571428571428 0.0569800569800569 K18335; 2-keto-3-deoxy-L-fuconate dehydrogenase [EC:1.1.1.-] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 221.0 26.0 25.0 2.0 0.962962962962963 IQ 1.0 26.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 27.0 0.037037037037037 0.9629629629629628 0.0033693050232102 0.0328114997519778 0.018090402387594 0.0294421947287676 0 0 0 0 K18336 0.0 0.0256410256410256 lra6; 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase [EC:3.7.1.26] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 274.0 9.0 0.0 1.0 1.0 Q 0.0 9.0 1.0 1.0 COG0179 2-keto-4-pentenoate_hydratase/2-oxohepta-3-ene-1,7-dioic_acid_hydratase_(catechol_pathway) YcgM 9.0 0.0 1.0 0.0010211132581959 0.0028297729772114 0.0019254431177036 0.0018086597190155 0 0 0 0 K18337 0.0142857142857142 0.0085470085470085 LRA1; L-rhamnose 1-dehydrogenase [EC:1.1.1.378 1.1.1.377 1.1.1.173] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 150.0 6.0 3.0 2.0 0.666666666666667 IQ 6.0 3.0 2.0 0.666666666666667 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 9.0 0.6666666666666666 0.3333333333333333 0.0098114060878925 0.0447172058609105 0.0272643059744015 0.034905799773018 0 0 0 0 K18344 0.0 0.0284900284900284 vanRB, vanR, vanRD; two-component system, OmpR family, response regulator VanR path:map01502,path:map02020 Vancomycin resistance,Two-component system 219.0 7.0 3.0 2.0 0.636363636363636 K 0.0 11.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 11.0 0.0 1.0 0.0024695564646204 0.0395961494920913 0.0210328529783558 0.0371265930274709 0 0 0 0 K18345 0.0 0.0199430199430199 vanSB, vanS, vanSD; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] path:map01502,path:map02020 Vancomycin resistance,Two-component system 437.0 8.0 0.0 1.0 1.0 T 0.0 8.0 2.0 0.875 COG5002 Sensor_histidine_kinase_WalK WalK 8.0 0.0 1.0 0.0110510646790229 0.0192126823091599 0.0151318734940914 0.008161617630137 0 0 0 0 K18346 0.0 0.074074074074074 vanW; vancomycin resistance protein VanW path:map01502,path:map02020 Vancomycin resistance,Two-component system 143.0 36.0 35.0 2.0 0.972972972972973 V 0.0 37.0 2.0 0.945945945945946 COG2720 Vancomycin_resistance_protein_YoaR_(function_unknown),_contains_peptidoglycan-binding_and_VanW_domains YoaR 37.0 0.0 1.0 0.0043966396824146 0.16109618880934 0.0827464142458773 0.1566995491269254 0 0 0 0 K18347 0.0028571428571428 0.0028490028490028 vanH; D-specific alpha-keto acid dehydrogenase [EC:1.1.1.-] path:map01502,path:map02020 Vancomycin resistance,Two-component system 283.0 2.0 0.0 1.0 1.0 CH 1.0 1.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 2.0 0.5 0.5 0 0 0 0 K18348 0.0 0.0256410256410256 vanT; serine/alanine racemase [EC:5.1.1.18 5.1.1.1] path:map01502,path:map02020 Vancomycin resistance,Two-component system 355.0 10.0 9.0 2.0 0.909090909090909 M 0.0 11.0 1.0 1.0 COG0787 Alanine_racemase Alr 11.0 0.0 1.0 0.0237490623063088 0.0588178255825357 0.0412834439444222 0.0350687632762269 0 0 0 0 K18349 0.0 0.0341880341880341 vanRC, vanRE, vanRG; two-component system, OmpR family, response regulator VanR path:map01502,path:map02020 Vancomycin resistance,Two-component system 220.0 8.0 3.0 3.0 0.533333333333333 T 0.0 15.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 15.0 0.0 1.0 0.0065032866634054 0.0115744260874688 0.0090388563754371 0.0050711394240634 0 0 0 0 K18350 0.0 0.0569800569800569 vanSC, vanSE, vanSG; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] path:map01502,path:map02020 Vancomycin resistance,Two-component system 205.0 27.0 0.0 1.0 1.0 T 0.0 27.0 3.0 0.481481481481481 COG5002 Sensor_histidine_kinase_WalK WalK 27.0 0.0 1.0 0.201014852832352 0.0152329522633738 0.1081239025478628 0.1857819005689782 0 0 0 0 K18351 0.0 0.0199430199430199 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3] path:map01502,path:map02020 Vancomycin resistance,Two-component system 353.0 10.0 0.0 1.0 1.0 T 0.0 10.0 2.0 0.6 COG4251 Bacteriophytochrome_(light-regulated_signal_transduction_histidine_kinase) 10.0 0.0 1.0 0.0093479533949378 0.0225289573254562 0.015938455360197 0.0131810039305183 0 0 0 0 K18352 0.0 0.0227920227920227 vanRAc; two-component system, OmpR family, response regulator VanR path:map01502,path:map02020 Vancomycin resistance,Two-component system 217.0 9.0 8.0 2.0 0.9 T 0.0 10.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 10.0 0.0 1.0 0.0030269394833396 0.0107121234536355 0.0068695314684875 0.0076851839702958 0 0 0 0 K18353 0.0 0.0256410256410256 vanJ; vancomycin resistance protein VanJ path:map01502,path:map02020 Vancomycin resistance,Two-component system 237.0 12.0 0.0 1.0 1.0 S 0.0 12.0 2.0 0.75 COG3021 Uncharacterized_conserved_protein_YafD,_endonuclease/exonuclease/phosphatase_(EEP)_superfamily YafD 12.0 0.0 1.0 0.0084751055639797 0.0191105477295741 0.0137928266467769 0.0106354421655944 0 0 0 0 K18354 0.0028571428571428 0.017094017094017 vanK; vancomycin resistance protein VanK path:map01502,path:map02020 Vancomycin resistance,Two-component system 257.0 7.0 0.0 1.0 1.0 V 1.0 6.0 1.0 1.0 COG2348 Lipid_II:glycine_glycyltransferase_(Peptidoglycan_interpeptide_bridge_formation_enzyme) FmhB 7.0 0.1428571428571428 0.8571428571428571 0.0502935160025357 0.974193073757526 0.5122432948800308 0.9238995577549902 0 0 0 0 K18356 0.0057142857142857 0.0142450142450142 padI; phenylglyoxylate dehydrogenase beta subunit [EC:1.2.1.58] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 113.0 9.0 0.0 1.0 1.0 C 4.0 5.0 3.0 0.777777777777778 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 9.0 0.4444444444444444 0.5555555555555556 0.0681941806034682 0.114155063062634 0.0911746218330511 0.0459608824591658 0 0 0 0 K18357 0.0114285714285714 0.0142450142450142 padE; phenylglyoxylate dehydrogenase gamma subunit [EC:1.2.1.58] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 172.0 9.0 0.0 1.0 1.0 C 4.0 5.0 1.0 1.0 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 9.0 0.4444444444444444 0.5555555555555556 0.0338783140269805 0.168750368583074 0.1013143413050272 0.1348720545560935 0 0 0 0 K18358 0.0171428571428571 0.0113960113960113 padF; phenylglyoxylate dehydrogenase delta subunit [EC:1.2.1.58] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 78.0 12.0 0.0 1.0 1.0 C 6.0 4.0 2.0 0.583333333333333 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 10.0 0.6 0.4 0.281128549650582 0.0734931585068919 0.1773108540787369 0.20763539114369 0 0 0 0 K18359 0.0 0.0056980056980056 padH; phenylglyoxylate dehydrogenase epsilon subunit [EC:1.2.1.58] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 375.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1251 NAD(P)H-nitrite_reductase,_large_subunit NirB 2.0 0.0 1.0 0 0 0 0 K18360 0.0 0.0085470085470085 padA; phenylacetyl-CoA:acceptor oxidoreductase accessory protein path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 258.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1526 Formate_dehydrogenase_assembly_factor_FdhD,_a_sulfurtransferase FdhD 3.0 0.0 1.0 0 0 0 0 K18361 0.0028571428571428 0.0028490028490028 padB; phenylacetyl-CoA:acceptor oxidoreductase [EC:1.17.5.1 3.1.2.25] path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 382.0 2.0 0.0 1.0 1.0 C 1.0 1.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 2.0 0.5 0.5 0 0 0 0 K18362 0.0028571428571428 0.0028490028490028 padC; phenylacetyl-CoA:acceptor oxidoreductase 27-kDa subunit path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 209.0 2.0 0.0 1.0 1.0 C 1.0 1.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 2.0 0.5 0.5 0 0 0 0 K18363 0.0 0.0028490028490028 padD; phenylacetyl-CoA:acceptor oxidoreductase 26-kDa subunit path:map00360,path:map01100 Phenylalanine metabolism,Metabolic pathways 292.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3302 DMSO_reductase_anchor_subunit_DmsC DmsC 1.0 0.0 1.0 0 0 0 0 K18364 0.0 0.017094017094017 bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132] path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 258.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 1.0 1.0 COG3971 2-keto-4-pentenoate_hydratase MhpD 7.0 0.0 1.0 0.008213543363014 0.0266025787814218 0.0174080610722179 0.0183890354184078 0 0 0 0 K18365 0.0 0.0113960113960113 bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43] path:map00362,path:map00621,path:map00622,path:map01100,path:map01120,path:map01220 Benzoate degradation,Dioxin degradation,Xylene degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 280.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0119 Isopropylmalate/homocitrate/citramalate_synthases LeuA 4.0 0.0 1.0 0.110656056862178 0.262824255309834 0.186740156086006 0.152168198447656 0 0 0 0 K18366 0.0 0.0085470085470085 bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87] path:map00362,path:map00620,path:map00621,path:map00622,path:map00650,path:map01100,path:map01120,path:map01220 Benzoate degradation,Pyruvate metabolism,Dioxin degradation,Xylene degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 295.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG4569 Acetaldehyde_dehydrogenase_(acetylating) MhpF 3.0 0.0 1.0 0 0 0 0 K18367 0.1342857142857142 0.0 CoADR; CoA-dependent NAD(P)H sulfur oxidoreductase [EC:1.8.1.18] 383.0 57.0 49.0 2.0 0.876923076923077 P 65.0 0.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 65.0 1.0 0.0 0.0307449768851253 0.0152550888784098 0.0230000328817675 0.0154898880067155 0 0 0 0 K18369 0.0 0.094017094017094 adh2; alcohol dehydrogenase [EC:1.1.1.-] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 311.0 27.0 18.0 2.0 0.75 E 0.0 36.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 36.0 0.0 1.0 0.082447406326607 0.404760705580488 0.2436040559535475 0.3223132992538809 0 0 0 0 K18370 0.0 0.017094017094017 adh3; alcohol dehydrogenase [EC:1.1.1.-] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 507.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 8.0 0.0 1.0 0.0041937710294286 0.0067432611378913 0.0054685160836599 0.0025494901084627 0 0 0 0 K18371 0.0 0.0256410256410256 acmA; acetone monooxygenase (methyl acetate-forming) [EC:1.14.13.226] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 498.0 5.0 1.0 3.0 0.5 P 0.0 10.0 2.0 0.9 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 10.0 0.0 1.0 0.0458237909029565 0.120459932952421 0.0831418619276887 0.0746361420494645 0 0 0 0 K18372 0.0 0.017094017094017 acmB; methyl acetate hydrolase [EC:3.1.1.114] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 345.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 6.0 0.0 1.0 0.0745235177586362 0.204920198213998 0.1397218579863171 0.1303966804553618 0 0 0 0 K18376 0.0 0.0056980056980056 hrpF; type III secretion translocon protein HrpF 315.0 1.0 0.0 2.0 0.5 NU 0.0 2.0 2.0 0.5 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 2.0 0.0 1.0 0 0 0 0 K18377 0.0 0.0028490028490028 hpa2; lysozyme-related protein Hpa2 167.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0741 Soluble_lytic_murein_transglycosylase_or_regulatory_protein_s_(_may_contain_LysM/invasin_domain) MltE 1.0 0.0 1.0 0 0 0 0 K18382 0.1085714285714285 0.0455840455840455 adh1; NAD+-dependent secondary alcohol dehydrogenase Adh1 [EC:1.1.1.-] path:map00650,path:map01100 Butanoate metabolism,Metabolic pathways 317.0 45.0 38.0 3.0 0.818181818181818 C 39.0 16.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 55.0 0.7090909090909091 0.2909090909090909 0.0501871084275962 0.758059060854218 0.4041230846409071 0.7078719524266218 0 0 0 0 K18383 0.0028571428571428 0.0142450142450142 ferB; feruloyl-CoA hydratase/lyase [EC:4.1.2.61] path:map00996,path:map01100,path:map01110 Biosynthesis of various alkaloids; Including: Cucurbitacin biosynthesis, Solanine and tomatine biosynthesis, Ephedrine biosynthesis, Capsaicin biosynthesis, Acridone alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 245.0 7.0 0.0 1.0 1.0 I 1.0 6.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 7.0 0.1428571428571428 0.8571428571428571 0.0191369155895604 0.0896488914403769 0.0543929035149686 0.0705119758508164 0 0 0 0 K18399 0.0 0.0056980056980056 BPHL; valacyclovir hydrolase [EC:3.1.-.-] 230.0 1.0 0.0 2.0 0.5 Q 0.0 2.0 2.0 0.5 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 2.0 0.0 1.0 0 0 0 0 K18425 0.0 0.0142450142450142 dhaa; 3-hydroxy-D-aspartate aldolase [EC:4.1.3.41] 387.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG3616 D-serine_deaminase,_pyridoxal_phosphate-dependent Dsd1 5.0 0.0 1.0 0.01019168748684 0.0277780977795383 0.0189848926331891 0.0175864102926983 0 0 0 0 K18427 0.0 0.0085470085470085 hpdB; 4-hydroxyphenylacetate decarboxylase large subunit [EC:4.1.1.83] 696.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1882 Pyruvate-formate_lyase PflD 4.0 0.0 1.0 4.26818273186463e-12 3.5151888117633204e-09 1.7597284972475923e-09 3.5109206290314553e-09 0 0 0 0 K18428 0.0 0.0028490028490028 hpdC; 4-hydroxyphenylacetate decarboxylase small subunit [EC:4.1.1.83] 91.0 0.0 1.0 1.0 1.0 2EKEX 1.0 0.0 1.0 0 0 0 0 K18429 0.0371428571428571 0.1054131054131054 legG, neuC2; GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing) [EC:3.2.1.184] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 297.0 53.0 0.0 1.0 1.0 M 14.0 39.0 1.0 1.0 COG0381 UDP-N-acetylglucosamine_2-epimerase WecB 53.0 0.2641509433962264 0.7358490566037735 0.371842843226018 0.626105343283524 0.498974093254771 0.2542625000575059 0 0 0 0 K18430 0.0371428571428571 0.1253561253561253 legI, neuB2; N,N'-diacetyllegionaminate synthase [EC:2.5.1.101] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 262.0 59.0 58.0 2.0 0.983333333333333 M 14.0 46.0 1.0 1.0 COG2089 Sialic_acid_synthase_SpsE,_contains_C-terminal_SAF_domain SpsE 60.0 0.2333333333333333 0.7666666666666667 0.264026053386753 0.3502179910234 0.3071220222050765 0.086191937636647 0 0 0 0 K18431 0.02 0.0883190883190883 legF, ptmB; CMP-N,N'-diacetyllegionaminic acid synthase [EC:2.7.7.82] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 138.0 36.0 29.0 2.0 0.837209302325581 M 8.0 35.0 2.0 0.837209302325581 COG1083 CMP-N-acetylneuraminic_acid_synthetase,_NeuA/PseF_family NeuA 43.0 0.1860465116279069 0.813953488372093 0.147805016622459 0.41494937304942 0.2813771948359395 0.267144356426961 0 0 0 0 K18434 0.0 0.0085470085470085 virD2; type IV secretion system T-DNA border endonuclease VirD2 298.0 3.0 0.0 1.0 1.0 L 0.0 3.0 1.0 1.0 COG3843 Type_IV_secretory_pathway,_VirD2_component_(relaxase) VirD2 3.0 0.0 1.0 0 0 0 0 K18444 0.0028571428571428 0.0056980056980056 rrp1; two-component system, glycerol uptake and utilization response regulator path:map02020 Two-component system 108.0 3.0 0.0 1.0 1.0 T 1.0 2.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18445 0.0285714285714285 0.0256410256410256 ndx1; diadenosine hexaphosphate hydrolase (ATP-forming) [EC:3.6.1.61] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 22.0 19.0 0.0 1.0 1.0 F 10.0 9.0 2.0 0.526315789473684 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 19.0 0.5263157894736842 0.4736842105263157 0.968175586302925 0.737239764037724 0.8527076751703244 0.230935822265201 1 1 1 1 K18446 0.0028571428571428 0.0484330484330484 ygiF; triphosphatase [EC:3.6.1.25] 116.0 19.0 0.0 1.0 1.0 S 1.0 18.0 1.0 1.0 COG3025 Inorganic_triphosphatase_YgiF,_contains_CYTH_and_CHAD_domains PPPi 19.0 0.0526315789473684 0.9473684210526316 0.0722219443853788 0.0280568560272141 0.0501394002062964 0.0441650883581647 0 0 0 0 K18447 0.0 0.0028490028490028 NUDX14; ADP-sugar diphosphatase [EC:3.6.1.21] path:map00051,path:map00230,path:map00500,path:map01100,path:map01110 Fructose and mannose metabolism,Purine metabolism,Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 242.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 1.0 0.0 1.0 0 0 0 0 K18454 0.0 0.0028490028490028 deaA; chitin disaccharide deacetylase [EC:3.5.1.105] 539.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 3.0 0.0 1.0 0 0 0 0 K18455 0.0 0.0968660968660968 mca; mycothiol S-conjugate amidase [EC:3.5.1.115] 248.0 38.0 0.0 1.0 1.0 S 0.0 38.0 1.0 1.0 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 38.0 0.0 1.0 0.0013927834204357 0.0098156627825262 0.0056042231014809 0.0084228793620905 0 0 0 0 K18456 0.0 0.0398860398860398 E3.5.4.32; 8-oxoguanine deaminase [EC:3.5.4.32] 434.0 14.0 0.0 1.0 1.0 F 0.0 14.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 14.0 0.0 1.0 0.0554618669272385 0.0600207917468988 0.0577413293370686 0.0045589248196602 0 0 0 0 K18457 0.0 0.037037037037037 laaA; L-proline amide hydrolase [EC:3.5.1.101] 268.0 6.0 0.0 3.0 0.428571428571429 I 0.0 14.0 2.0 0.571428571428571 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 14.0 0.0 1.0 0.0073736860649413 0.0348540032091253 0.0211138446370333 0.027480317144184 0 0 0 0 K18459 0.0057142857142857 0.0484330484330484 gpuA; guanidinopropionase [EC:3.5.3.17] 245.0 21.0 0.0 1.0 1.0 E 2.0 19.0 1.0 1.0 COG0010 Arginase/agmatinase_family_enzyme SpeB 21.0 0.0952380952380952 0.9047619047619048 0.0151032296102419 0.0619753770496766 0.0385393033299592 0.0468721474394347 0 0 0 0 K18467 0.0028571428571428 0.0 VPS29; vacuolar protein sorting-associated protein 29 path:map04144 Endocytosis 191.0 1.0 0.0 1.0 1.0 U 1.0 0.0 1.0 1.0 COG0622 Predicted_phosphodiesterase,_calcineurin_family YfcE 1.0 1.0 0.0 0 0 0 0 K18469 0.0171428571428571 0.0 TBC1D5; TBC1 domain family member 5 367.0 6.0 0.0 1.0 1.0 H 6.0 0.0 1.0 1.0 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 6.0 1.0 0.0 1.46617318892881e-05 9.15689466302132e-05 5.3115339259750645e-05 7.69072147409251e-05 0 0 0 0 K18471 0.0 0.0313390313390313 ydjG; methylglyoxal reductase [EC:1.1.1.-] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 307.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 11.0 0.0 1.0 0.153329776811688 0.284249648737875 0.2187897127747815 0.130919871926187 0 0 0 0 K18472 0.0 0.0341880341880341 accD6; acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] path:map00061,path:map00280,path:map00620,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200,path:map01212 Fatty acid biosynthesis,Valine, leucine and isoleucine degradation,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Fatty acid metabolism 463.0 13.0 0.0 1.0 1.0 I 0.0 13.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 13.0 0.0 1.0 0.0005162623264338 3.89049223130798e-05 0.0002775836243734 0.0004773574041207 0 0 0 0 K18473 0.0 0.0113960113960113 fabY; acetoacetyl-[acyl-carrier protein] synthase [EC:2.3.1.180] path:map00061,path:map01100,path:map01212 Fatty acid biosynthesis,Metabolic pathways,Fatty acid metabolism 458.0 3.0 2.0 2.0 0.75 IQ 0.0 4.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 4.0 0.0 1.0 0.0033917658357946 0.0106783829150883 0.0070350743754414 0.0072866170792937 0 0 0 0 K18474 0.0 0.0085470085470085 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] path:map00061 Fatty acid biosynthesis 254.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 3.0 0.0 1.0 0 0 0 0 K18475 0.0 0.0598290598290598 fliB; lysine-N-methylase [EC:2.1.1.-] 67.0 23.0 0.0 1.0 1.0 S 0.0 23.0 1.0 1.0 COG0727 Uncharacterized_protein_YkgJ,_contains_CxxCxxCC_motif YkgJ 23.0 0.0 1.0 0.0232971742600755 0.054317076217658 0.0388071252388667 0.0310199019575825 0 0 0 0 K18476 0.0028571428571428 0.0142450142450142 tetR; TetR/AcrR family transcriptional regulator, tetracycline repressor protein 205.0 6.0 0.0 1.0 1.0 K 1.0 5.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 6.0 0.1666666666666666 0.8333333333333334 0.0672749835954629 0.0812488260835608 0.0742619048395118 0.0139738424880978 0 0 0 0 K18478 0.0314285714285714 0.0398860398860398 yihV; sulfofructose kinase [EC:2.7.1.184] 252.0 24.0 23.0 2.0 0.96 G 11.0 14.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 25.0 0.44 0.56 0.035181519377547 0.0665853534469612 0.0508834364122541 0.0314038340694142 0 0 0 0 K18479 0.0 0.0056980056980056 yihS; sulfoquinovose isomerase [EC:5.3.1.31] 388.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG2942 Mannose_or_cellobiose_epimerase,_N-acyl-D-glucosamine_2-epimerase_family YihS 2.0 0.0 1.0 0 0 0 0 K18480 0.0 0.1253561253561253 linN; cholesterol transport system auxiliary component 54.0 29.0 11.0 2.0 0.617021276595745 S 0.0 47.0 2.0 0.765957446808511 COG3218 ABC-type_uncharacterized_transport_system,_auxiliary_component 47.0 0.0 1.0 0.0098679181966072 0.057999122400752 0.0339335202986796 0.0481312042041448 0 0 0 0 K18481 0.0 0.0484330484330484 mas; Mce-associated membrane protein 39.0 10.0 3.0 2.0 0.588235294117647 O 0.0 45.0 21.0 0.133333333333333 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 45.0 0.0 1.0 0.0035968506924982 0.0090589883963508 0.0063279195444245 0.0054621377038526 0 0 0 0 K18491 0.0028571428571428 0.0199430199430199 ESX1; homeobox protein ESX1 path:map04550 Signaling pathways regulating pluripotency of stem cells 155.0 3.0 1.0 5.0 0.375 D 1.0 7.0 5.0 0.375 COG0613 5'-3'_exoribonuclease_TrpH/YciV_(RNase_AM),_contains_PHP_domain YciV 8.0 0.125 0.875 0.203469639012478 0.245980515775393 0.2247250773939355 0.042510876762915 0 0 0 0 K18500 0.0171428571428571 0.0 hmeC; heterodisulfide reductase cytochrome b-like subunit 245.0 6.0 0.0 1.0 1.0 C 6.0 0.0 1.0 1.0 COG2181 Nitrate_reductase_gamma_subunit NarI 6.0 1.0 0.0 0.0054985560505853 0.0073455549154318 0.0064220554830085 0.0018469988648464 0 0 0 0 K18501 0.0314285714285714 0.0 hmeD; heterodisulfide reductase iron-sulfur subunit 425.0 16.0 0.0 1.0 1.0 C 16.0 0.0 1.0 1.0 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 16.0 1.0 0.0 0.0601286525392879 0.0227943132681246 0.0414614829037062 0.0373343392711632 0 0 0 0 K18530 0.0 0.0028490028490028 frvX; putative aminopeptidase FrvX [EC:3.4.11.-] 328.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG1363 Putative_aminopeptidase_FrvX FrvX 3.0 0.0 1.0 0 0 0 0 K18531 0.0 0.0028490028490028 frvR; putative frv operon regulatory protein 582.0 1.0 0.0 1.0 1.0 GKT 0.0 1.0 1.0 1.0 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 1.0 0.0 1.0 0 0 0 0 K18532 0.8085714285714286 0.0056980056980056 AK6, FAP7; adenylate kinase [EC:2.7.4.3] path:map00230,path:map01100,path:map01110,path:map01232,path:map01240,path:map03008 Purine metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Nucleotide metabolism,Biosynthesis of cofactors,Ribosome biogenesis in eukaryotes 71.0 295.0 0.0 1.0 1.0 F 293.0 2.0 2.0 0.993220338983051 COG1936 Broad-specificity_NMP_kinase Fap7 295.0 0.9932203389830508 0.0067796610169491 0.0244049131411753 0.0339638038215178 0.0291843584813465 0.0095588906803424 0 0 0 0 K18534 0.0028571428571428 0.0484330484330484 K18534; MPBQ/MSBQ methyltransferase [EC:2.1.1.295] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 196.0 10.0 1.0 3.0 0.476190476190476 H 1.0 20.0 3.0 0.714285714285714 COG0500 SAM-dependent_methyltransferase SmtA 21.0 0.0476190476190476 0.9523809523809524 0.106471588654986 0.0686128783401684 0.0875422334975772 0.0378587103148176 0 0 0 0 K18537 0.0028571428571428 0.0 thnK; putative methyltransferase 660.0 1.0 0.0 1.0 1.0 C 1.0 0.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 1.0 1.0 0.0 0 0 0 0 K18538 0.0028571428571428 0.0085470085470085 thnN; thienamycin biosynthesis protein ThnN 334.0 5.0 0.0 1.0 1.0 H 1.0 4.0 1.0 1.0 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 5.0 0.2 0.8 0.0664719341134081 0.139102746961043 0.1027873405372255 0.0726308128476349 0 0 0 0 K18539 0.0 0.0085470085470085 thnO; thienamycin biosynthesis protein ThnO 455.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 4.0 0.0 1.0 3.43866791320935e-05 0.0011798863724345 0.0006071365257832 0.0011454996933024 0 0 0 0 K18540 0.0942857142857142 0.0056980056980056 ramA; (R)-amidase [EC:3.5.1.100] 187.0 30.0 25.0 2.0 0.857142857142857 S 33.0 2.0 1.0 1.0 COG0388 Omega-amidase_YafV/Nit2,_hydrolyzes_alpha-ketoglutaramate Nit2 35.0 0.9428571428571428 0.0571428571428571 0.0008591826968991 0.0023524265460069 0.001605804621453 0.0014932438491078 0 0 0 0 K18546 0.0085714285714285 0.0541310541310541 sprC; streptogrisin C [EC:3.4.21.-] 82.0 20.0 15.0 5.0 0.588235294117647 S 3.0 32.0 6.0 0.457142857142857 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 35.0 0.0857142857142857 0.9142857142857144 0.0025535057557541 0.005399840023997 0.0039766728898755 0.0028463342682429 0 0 0 0 K18547 0.0 0.0085470085470085 sprD; streptogrisin D [EC:3.4.21.-] 274.0 3.0 0.0 1.0 1.0 O 0.0 3.0 1.0 1.0 COG0265 Periplasmic_serine_protease,_S1-C_subfamily,_contain_C-terminal_PDZ_domain DegQ 3.0 0.0 1.0 0 0 0 0 K18550 0.0 0.0028490028490028 ISN1; IMP and pyridine-specific 5'-nucleotidase [EC:3.1.3.99 3.1.3.-] path:map00230,path:map00760,path:map01100,path:map01232 Purine metabolism,Nicotinate and nicotinamide metabolism,Metabolic pathways,Nucleotide metabolism 67.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 1.0 0.0 1.0 0 0 0 0 K18552 0.0 0.0284900284900284 cmlA, cmlB, floR; MFS transporter, DHA1 family, chloramphenicol/florfenicol resistance protein 374.0 10.0 0.0 1.0 1.0 EGP 0.0 10.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 10.0 0.0 1.0 0 0 0 0 K18553 0.0 0.0227920227920227 cmlR, cmx; MFS transporter, DHA1 family, chloramphenicol resistance protein 381.0 10.0 0.0 1.0 1.0 EGP 0.0 10.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 10.0 0.0 1.0 0 0 0 0 K18554 0.0085714285714285 0.037037037037037 cpt; chloramphenicol 3-O phosphotransferase [EC:2.7.1.-] 155.0 17.0 0.0 1.0 1.0 V 3.0 14.0 1.0 1.0 COG3896 Chloramphenicol_3-O-phosphotransferase 17.0 0.1764705882352941 0.8235294117647058 0.403986660180039 0.829413912820419 0.616700286500229 0.42542725264038 0 0 0 0 K18555 0.0 0.0142450142450142 qnr, mcbG; fluoroquinolone resistance protein 147.0 3.0 2.0 3.0 0.6 S 0.0 5.0 1.0 1.0 COG1357 Uncharacterized_conserved_protein_YjbI,_contains_pentapeptide_repeats YjbI 5.0 0.0 1.0 0.0784543883261265 0.16980626729736 0.1241303278117432 0.0913518789712335 0 0 0 0 K18556 0.0142857142857142 0.0085470085470085 frdA; NADH-dependent fumarate reductase subunit A [EC:1.3.1.6] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 462.0 8.0 0.0 1.0 1.0 C 5.0 3.0 1.0 1.0 COG1053 Succinate_dehydrogenase/fumarate_reductase,_flavoprotein_subunit SdhA 8.0 0.625 0.375 0.011438583040191 0.0186859456160096 0.0150622643281003 0.0072473625758186 0 0 0 0 K18557 0.0 0.0113960113960113 frdB; NADH-dependent fumarate reductase subunit B [EC:1.3.1.6] path:map00720,path:map01100,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Carbon metabolism 192.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG0479 Succinate_dehydrogenase/fumarate_reductase,_Fe-S_protein_subunit SdhB/FrdB 4.0 0.0 1.0 0.0034925405730487 4.39581132988095e-06 0.0017484681921892 0.0034881447617188 0 0 0 0 K18558 0.0057142857142857 0.0085470085470085 frdC; NADH-dependent fumarate reductase subunit C path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 434.0 6.0 0.0 1.0 1.0 C 3.0 3.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 6.0 0.5 0.5 0.186032991214571 0.104965204290974 0.1454990977527725 0.081067786923597 0 0 0 0 K18559 0.0 0.0056980056980056 frdD; NADH-dependent fumarate reductase subunit D path:map00720,path:map01200 Carbon fixation pathways in prokaryotes,Carbon metabolism 447.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 2.0 0.0 1.0 0 0 0 0 K18560 0.0 0.0056980056980056 frdE; NADH-dependent fumarate reductase subunit E path:map00720,path:map01200 Carbon fixation pathways in prokaryotes,Carbon metabolism 163.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 2.0 0.0 1.0 0 0 0 0 K18562 0.0 0.0056980056980056 thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-] path:map00332,path:map01100,path:map01110 Carbapenem biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 226.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 2.0 0.0 1.0 0 0 0 0 K18563 0.0 0.0028490028490028 thnL; methyltransferase [EC:2.1.1.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 432.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 1.0 0.0 1.0 0 0 0 0 K18564 0.0028571428571428 0.0056980056980056 thnP; methyltransferase [EC:2.1.1.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 368.0 3.0 0.0 1.0 1.0 C 1.0 2.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18565 0.0 0.0113960113960113 thnG, cmmG; 2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 187.0 27.0 0.0 1.0 1.0 Q 0.0 27.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 27.0 0.0 1.0 1.6708425509153502e-14 6.19061225494498e-14 3.9307274029301655e-14 4.51976970402963e-14 0 0 0 0 K18566 0.0114285714285714 0.0028490028490028 thnF, cmmF; N-acetyltransferase [EC:2.3.1.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 283.0 6.0 0.0 1.0 1.0 K 5.0 1.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 6.0 0.8333333333333334 0.1666666666666666 0.0102644316627694 0.0043482437516904 0.0073063377072298 0.0059161879110789 0 0 0 0 K18567 0.0 0.0398860398860398 pbuE; MFS transporter, DHA1 family, purine base/nucleoside efflux pump 359.0 13.0 11.0 3.0 0.8125 EGP 0.0 16.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 16.0 0.0 1.0 0 0 0 0 K18568 0.0 0.0598290598290598 thnR; CoA pyrophosphatase [EC:3.6.1.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 187.0 22.0 0.0 1.0 1.0 L 0.0 22.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 22.0 0.0 1.0 0.0066069088570921 0.0156566488451523 0.0111317788511222 0.0090497399880602 0 0 0 0 K18569 0.0 0.0142450142450142 thnH; hydrolase [EC:3.1.3.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 209.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 5.0 0.0 1.0 0.0165789695895308 0.142442034613124 0.0795105021013274 0.1258630650235931 0 0 0 0 K18570 0.0114285714285714 0.0056980056980056 cmm17; putative hydratase path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 311.0 6.0 0.0 1.0 1.0 I 4.0 2.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 6.0 0.6666666666666666 0.3333333333333333 0.0483816424893027 0.362602321614766 0.2054919820520343 0.3142206791254633 0 0 0 0 K18572 0.0 0.017094017094017 cmmT, thnT; putative pantetheine hydrolase [EC:3.5.1.-] path:map00332,path:map01110 Carbapenem biosynthesis,Biosynthesis of secondary metabolites 306.0 6.0 0.0 1.0 1.0 EQ 0.0 6.0 1.0 1.0 COG3191 L-aminopeptidase/D-esterase DmpA 6.0 0.0 1.0 1.27589325110683e-05 8.60066904787888e-09 6.3837665900580894e-06 1.275033184202042e-05 0 0 0 0 K18574 0.0 0.0199430199430199 ptpA; Xaa-Xaa-Pro tripeptidyl-peptidase [EC:3.4.14.12] 696.0 7.0 0.0 1.0 1.0 E 0.0 7.0 1.0 1.0 COG1506 Dipeptidyl_aminopeptidase/acylaminoacyl_peptidase DAP2 7.0 0.0 1.0 0.006129169135489 0.0128026379016072 0.0094659035185481 0.0066734687661182 0 0 0 0 K18579 0.0 0.0085470085470085 6GAL; galactan endo-1,6-beta-galactosidase [EC:3.2.1.164] 461.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 2.0 0.666666666666667 COG5520 O-Glycosyl_hydrolase XynC 3.0 0.0 1.0 0 0 0 0 K18581 0.0142857142857142 0.0683760683760683 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] 225.0 21.0 7.0 3.0 0.583333333333333 S 7.0 29.0 2.0 0.611111111111111 COG4225 Rhamnogalacturonyl_hydrolase_YesR YesR 36.0 0.1944444444444444 0.8055555555555556 0.0341676817846335 0.0669618236343922 0.0505647527095128 0.0327941418497586 0 0 0 0 K18586 0.0 0.0056980056980056 COQ4; ubiquinone biosynthesis protein COQ4 251.0 2.0 0.0 1.0 1.0 H 0.0 2.0 1.0 1.0 COG5031 Ubiquinone_biosynthesis_protein_Coq4 COQ4 2.0 0.0 1.0 0 0 0 0 K18587 0.0 0.074074074074074 COQ9; ubiquinone biosynthesis protein COQ9 193.0 26.0 0.0 1.0 1.0 S 0.0 26.0 1.0 1.0 COG5590 Ubiquinone_biosynthesis_protein_COQ9 26.0 0.0 1.0 0.0025769736803115 0.0056103503369245 0.004093662008618 0.0030333766566129 0 0 0 0 K18588 0.0 0.094017094017094 COQ10; coenzyme Q-binding protein COQ10 130.0 34.0 0.0 1.0 1.0 I 0.0 34.0 1.0 1.0 COG2867 Ribosome_association_toxin_PasT_(RatA)_of_the_RatAB_toxin-antitoxin_module PasT 34.0 0.0 1.0 0.001082374363364 0.0036456858767363 0.0023640301200501 0.0025633115133723 0 0 0 0 K18589 0.0 0.0142450142450142 dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] path:map00670,path:map00790,path:map01100 One carbon pool by folate,Folate biosynthesis,Metabolic pathways 155.0 5.0 0.0 1.0 1.0 H 0.0 5.0 1.0 1.0 COG0262 Dihydrofolate_reductase FolA 5.0 0.0 1.0 0.120419899390725 0.264903524012675 0.1926617117017 0.1444836246219499 0 0 0 0 K18590 0.0085714285714285 0.037037037037037 dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3] path:map00670,path:map00790,path:map01100 One carbon pool by folate,Folate biosynthesis,Metabolic pathways 142.0 16.0 0.0 1.0 1.0 H 3.0 13.0 1.0 1.0 COG0262 Dihydrofolate_reductase FolA 16.0 0.1875 0.8125 0.0151569669981903 0.0409209641938538 0.028038965596022 0.0257639971956634 0 0 0 0 K18593 0.0342857142857142 0.0 E6.2.1.56; 4-hydroxybutyrate---CoA ligase (ADP-forming) [EC:6.2.1.56] path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 689.0 12.0 0.0 1.0 1.0 C 12.0 0.0 1.0 1.0 COG1042 Acyl-CoA_synthetase_(NDP_forming) PatZN 12.0 1.0 0.0 0.0025856126324792 0.0038634494248242 0.0032245310286517 0.001277836792345 0 0 0 0 K18594 0.0828571428571428 0.0028490028490028 K18594; 3-hydroxypropionyl-CoA synthetase (ADP-forming) [EC:6.2.1.-] path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 214.0 31.0 0.0 1.0 1.0 C 30.0 1.0 1.0 1.0 COG1042 Acyl-CoA_synthetase_(NDP_forming) PatZN 31.0 0.967741935483871 0.032258064516129 0.621001301901868 0.836494885664967 0.7287480937834174 0.215493583763099 0 0 0 1 K18601 0.0314285714285714 0.0028490028490028 K18601; aldehyde dehydrogenase [EC:1.2.1.-] 427.0 14.0 0.0 1.0 1.0 C 13.0 1.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 14.0 0.9285714285714286 0.0714285714285714 0.110037593141025 0.794998537817867 0.452518065479446 0.684960944676842 0 0 0 0 K18602 0.0342857142857142 0.0 K18602; malonic semialdehyde reductase [EC:1.1.1.-] path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 312.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 15.0 1.0 0.0 0.0045344956382648 0.0083643054649067 0.0064494005515857 0.0038298098266419 0 0 0 0 K18603 0.0342857142857142 0.0 K18603; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 486.0 12.0 0.0 1.0 1.0 I 12.0 0.0 1.0 1.0 COG0439 Biotin_carboxylase AccC 12.0 1.0 0.0 9.09518083701721e-05 0.000382976543934 0.000236964176152 0.0002920247355638 0 0 0 0 K18604 0.0371428571428571 0.0 K18604; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 513.0 13.0 0.0 1.0 1.0 I 13.0 0.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 13.0 1.0 0.0 2.31181143335312e-13 0.0003425376294157 0.0001712688148234 0.0003425376291845 0 0 0 0 K18605 0.0714285714285714 0.0 K18605; biotin carboxyl carrier protein path:map00720,path:map01100,path:map01120 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments 128.0 13.0 1.0 2.0 0.52 I 25.0 0.0 2.0 0.52 COG0511 Biotin_carboxyl_carrier_protein AccB 25.0 1.0 0.0 0.0008326290041269 0.0065172489346681 0.0036749389693974 0.0056846199305412 0 0 0 0 K18607 0.0 0.0056980056980056 pno; pyridoxine 4-oxidase [EC:1.1.3.12] path:map00750,path:map01100,path:map01120 Vitamin B6 metabolism,Metabolic pathways,Microbial metabolism in diverse environments 489.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 2.0 0.0 1.0 0 0 0 0 K18608 0.0 0.0113960113960113 ppaT; pyridoxamine---pyruvate transaminase [EC:2.6.1.30] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 329.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0075 Archaeal_aspartate_aminotransferase_or_a_related_aminotransferase,_includes_purine_catabolism_protein_PucG PucG 4.0 0.0 1.0 3.19523331882672e-12 7.86131359682747e-12 5.528273457827095e-12 4.6660802780007495e-12 0 0 0 0 K18609 0.0 0.0056980056980056 pldh; pyridoxal 4-dehydrogenase [EC:1.1.1.107] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 246.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K18610 0.0 0.0056980056980056 pdla; 4-pyridoxolactonase [EC:3.1.1.27] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 268.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 2.0 0.0 1.0 0 0 0 0 K18612 0.0 0.0085470085470085 E1.2.1.100; 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase [EC:1.2.1.100] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 281.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG1250 3-hydroxyacyl-CoA_dehydrogenase FadB 3.0 0.0 1.0 0 0 0 0 K18613 0.0028571428571428 0.0028490028490028 K18613; 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase [EC:4.1.1.51] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 80.0 2.0 0.0 1.0 1.0 G 1.0 1.0 1.0 1.0 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 2.0 0.5 0.5 0 0 0 0 K18614 0.0142857142857142 0.0142450142450142 K18614; 2-(acetamidomethylene)succinate hydrolase [EC:3.5.1.29] path:map00750,path:map01120 Vitamin B6 metabolism,Microbial metabolism in diverse environments 151.0 1.0 0.0 1.0 1.0 S 5.0 5.0 2.0 0.9 COG2945 Alpha/beta_superfamily_hydrolase 10.0 0.5 0.5 0.153623460664617 0.284009325429171 0.218816393046894 0.130385864764554 0 0 0 0 K18626 0.0 0.0028490028490028 TCHH; trichohyalin 1244.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K18640 0.0085714285714285 0.1054131054131054 parM, stbA; plasmid segregation protein ParM 79.0 26.0 12.0 4.0 0.530612244897959 O 3.0 52.0 8.0 0.490909090909091 COG0443 Molecular_chaperone_DnaK_(HSP70) DnaK 55.0 0.0545454545454545 0.9454545454545454 0.0343613512965473 0.492029648676253 0.2631954999864001 0.4576682973797057 0 0 0 0 K18641 0.0714285714285714 0.0 K18641; crenactin 400.0 27.0 0.0 1.0 1.0 S 27.0 0.0 1.0 1.0 arCOG05583 27.0 1.0 0.0 0.0021438152096805 0.0104547587239222 0.0062992869668013 0.0083109435142416 0 0 0 0 K18649 0.0 0.0797720797720797 IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15] path:map00053,path:map00340,path:map00562,path:map01100,path:map01110,path:map01230,path:map04070 Ascorbate and aldarate metabolism,Histidine metabolism,Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of amino acids,Phosphatidylinositol signaling system 234.0 29.0 0.0 1.0 1.0 G 0.0 29.0 1.0 1.0 COG0483 Archaeal_fructose-1,6-bisphosphatase_or_related_enzyme,_inositol_monophosphatase_family SuhB 29.0 0.0 1.0 0.0052296033008103 0.0039781782511314 0.0046038907759708 0.0012514250496788 0 0 0 0 K18650 0.0 0.0085470085470085 pehX; exo-poly-alpha-galacturonosidase [EC:3.2.1.82] 256.0 2.0 1.0 2.0 0.666666666666667 N 0.0 3.0 3.0 0.333333333333333 COG3420 Nitrous_oxide_reductase_accessory_protein_NosD,_contains_tandem_CASH_domains NosD 3.0 0.0 1.0 0 0 0 0 K18652 0.0 0.0085470085470085 ntdC; glucose-6-phosphate 3-dehydrogenase [EC:1.1.1.361] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 295.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 3.0 0.0 1.0 0 0 0 0 K18653 0.0057142857142857 0.0227920227920227 ntdA; 3-dehydro-glucose-6-phosphate---glutamate transaminase [EC:2.6.1.104] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 356.0 10.0 0.0 1.0 1.0 E 2.0 8.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 10.0 0.2 0.8 0.257097417869478 0.659893492161476 0.4584954550154769 0.402796074291998 0 0 0 0 K18654 0.0 0.0085470085470085 ntdB; kanosamine-6-phosphate phosphatase [EC:3.1.3.92] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 271.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 3.0 0.0 1.0 0 0 0 0 K18657 0.0 0.0142450142450142 zapC; cell division protein ZapC 176.0 5.0 0.0 1.0 1.0 D 0.0 5.0 1.0 1.0 28I7M 5.0 0.0 1.0 9.41862059210102e-12 4.23593303809909e-08 2.11843745007915e-08 4.23499117603988e-08 0 0 0 0 K18660 0.0028571428571428 0.0199430199430199 ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-] path:map00061,path:map00280,path:map01100,path:map01212 Fatty acid biosynthesis,Valine, leucine and isoleucine degradation,Metabolic pathways,Fatty acid metabolism 448.0 10.0 0.0 1.0 1.0 IQ 1.0 10.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 11.0 0.0909090909090909 0.9090909090909092 0.0065359430868373 0.027354921521481 0.0169454323041591 0.0208189784346437 0 0 0 0 K18661 0.0228571428571428 0.094017094017094 matB; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 354.0 50.0 0.0 1.0 1.0 IQ 9.0 41.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 50.0 0.18 0.82 0.0046017924162872 0.131601755088715 0.0681017737525011 0.1269999626724278 0 0 0 0 K18662 0.0 0.0227920227920227 matB; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-] path:map00280,path:map01100 Valine, leucine and isoleucine degradation,Metabolic pathways 455.0 10.0 0.0 1.0 1.0 IQ 0.0 10.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 10.0 0.0 1.0 0.0013128538234399 0.0056183611104879 0.0034656074669638 0.004305507287048 0 0 0 0 K18665 0.0028571428571428 0.0 NUDT8; nudix motif 8 [EC:3.6.1.-] 181.0 1.0 0.0 1.0 1.0 L 1.0 0.0 1.0 1.0 COG0494 8-oxo-dGTP_pyrophosphatase_MutT_and_related_house-cleaning_NTP_pyrophosphohydrolases,_NUDIX_family MutT 1.0 1.0 0.0 0 0 0 0 K18672 0.0028571428571428 0.3561253561253561 dacA; diadenylate cyclase [EC:2.7.7.85] 167.0 123.0 121.0 3.0 0.976190476190476 S 1.0 125.0 1.0 1.0 COG1624 c-di-AMP_synthetase,_contains_DisA_N_domain DisA 126.0 0.0079365079365079 0.992063492063492 0.0715964240364327 0.596293946864318 0.3339451854503754 0.5246975228278853 0 0 0 0 K18673 0.0 0.0028490028490028 bglK; beta-glucoside kinase [EC:2.7.1.85] 276.0 1.0 0.0 1.0 1.0 GK 0.0 1.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 1.0 0.0 1.0 0 0 0 0 K18674 0.0057142857142857 0.0113960113960113 GALK2; N-acetylgalactosamine kinase [EC:2.7.1.157] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 109.0 5.0 2.0 2.0 0.625 M 3.0 5.0 1.0 1.0 COG0153 Galactokinase GalK 8.0 0.375 0.625 0.0275201486406268 0.0505209740731579 0.0390205613568923 0.0230008254325311 0 0 0 0 K18675 0.0 0.0142450142450142 chbP; N,N'-diacetylchitobiose phosphorylase [EC:2.4.1.280] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 754.0 7.0 0.0 1.0 1.0 G 0.0 7.0 1.0 1.0 COG3459 Cellobiose_phosphorylase 7.0 0.0 1.0 0.0183253475397589 0.0593749991937327 0.0388501733667458 0.0410496516539738 0 0 0 0 K18676 0.0 0.0655270655270655 gspK; glucosamine kinase [EC:2.7.1.8] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 211.0 27.0 0.0 1.0 1.0 G 0.0 27.0 1.0 1.0 COG2971 BadF-type_ATPase,_related_to_human_N-acetylglucosamine_kinase BadF 27.0 0.0 1.0 0.0306790561493628 0.0722028336274765 0.0514409448884196 0.0415237774781137 0 0 0 0 K18677 0.0028571428571428 0.0028490028490028 GALAK; galacturonokinase [EC:2.7.1.44] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 385.0 2.0 0.0 1.0 1.0 G 1.0 1.0 1.0 1.0 COG0153 Galactokinase GalK 2.0 0.5 0.5 0 0 0 0 K18678 0.0514285714285714 0.074074074074074 VTE5; phytol kinase [EC:2.7.1.182] 159.0 44.0 43.0 3.0 0.956521739130435 I 18.0 28.0 1.0 1.0 COG0170 Dolichol_kinase SEC59 46.0 0.391304347826087 0.6086956521739131 0.229423351083435 0.830630852508361 0.530027101795898 0.601207501424926 0 0 0 0 K18682 0.0 0.6666666666666666 rny; ribonucrease Y [EC:3.1.-.-] path:map03018 RNA degradation 364.0 153.0 117.0 9.0 0.6 S 0.0 257.0 9.0 0.88715953307393 COG1418 HD_superfamily_phosphodieaserase,_includes_HD_domain_of_RNase_Y RnaY 257.0 0.0 1.0 0.890642109972495 0.0076159177783601 0.4491290138754276 0.8830261921941349 0 0 1 1 K18684 0.0 0.0028490028490028 ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7] 75.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 28IFU 1.0 0.0 1.0 0 0 0 0 K18687 0.0 0.0284900284900284 fadD3; HIP---CoA ligase [EC:6.2.1.41] path:map00984,path:map01100,path:map01120 Steroid degradation,Metabolic pathways,Microbial metabolism in diverse environments 473.0 11.0 0.0 1.0 1.0 IQ 0.0 11.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 11.0 0.0 1.0 0.0043761797819403 0.0189968218592911 0.0116865008206157 0.0146206420773508 0 0 0 0 K18688 0.0028571428571428 0.0199430199430199 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42] 522.0 10.0 0.0 1.0 1.0 IQ 2.0 8.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 10.0 0.2 0.8 0.0018380637191024 0.0063904638932447 0.0041142638061735 0.0045524001741423 0 0 0 0 K18689 0.0485714285714285 0.0 E2.7.1.185; mevalonate-3-kinase [EC:2.7.1.185] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 286.0 10.0 2.0 2.0 0.555555555555556 F 18.0 0.0 1.0 1.0 COG3407 Mevalonate_pyrophosphate_decarboxylase MVD1 18.0 1.0 0.0 5.03127838410093e-12 0.0001206658164486 6.033291073993919e-05 0.0001206658114173 0 0 0 0 K18690 0.0314285714285714 0.0 E2.7.1.186; mevalonate-3-phosphate-5-kinase [EC:2.7.1.186] path:map00900,path:map01100,path:map01110 Terpenoid backbone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 196.0 11.0 0.0 1.0 1.0 F 11.0 0.0 1.0 1.0 COG2074 2-phosphoglycerate_kinase/Mevalonate-3-phosphate_5-kinase Pgk2 11.0 1.0 0.0 5.40957455088898e-12 0.0062970063301772 0.0031485031677933 0.0062970063247676 0 0 0 0 K18691 0.0 0.131054131054131 mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-] 257.0 51.0 0.0 1.0 1.0 M 0.0 51.0 2.0 0.96078431372549 COG4623 Membrane-bound_lytic_murein_transglycosylase_MltF MltF 51.0 0.0 1.0 0.0117054697362854 0.0229735190979931 0.0173394944171392 0.0112680493617077 0 0 0 0 K18692 0.0 0.0541310541310541 cshB; ATP-dependent RNA helicase CshB [EC:3.6.4.13] 399.0 9.0 1.0 3.0 0.473684210526316 L 0.0 19.0 1.0 1.0 COG0513 Superfamily_II_DNA_and_RNA_helicase SrmB 19.0 0.0 1.0 5.554330638624251e-10 2.22633277191707e-12 2.78829698317171e-10 5.53206731090508e-10 0 0 0 0 K18697 0.0 0.0199430199430199 pgpC; phosphatidylglycerophosphatase C [EC:3.1.3.27] path:map00564 Glycerophospholipid metabolism 120.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG0560 Phosphoserine_phosphatase SerB 8.0 0.0 1.0 0.05720338869258 0.156995258809525 0.1070993237510525 0.099791870116945 0 0 0 0 K18698 0.0 0.0085470085470085 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6] path:map01501 beta-Lactam resistance 38.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 3.0 0.0 1.0 0 0 0 0 K18699 0.0 0.0085470085470085 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6] path:map01501 beta-Lactam resistance 38.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 3.0 0.0 1.0 0 0 0 0 K18700 0.0114285714285714 0.0484330484330484 flK; fluoroacetyl-CoA thioesterase [EC:3.1.2.29] 122.0 23.0 0.0 1.0 1.0 S 4.0 19.0 1.0 1.0 COG5496 Predicted_thioesterase 23.0 0.1739130434782608 0.8260869565217391 0.0319735339578449 0.491540686732615 0.2617571103452299 0.45956715277477 0 0 0 0 K18701 0.0028571428571428 0.0256410256410256 arsC; arsenate-mycothiol transferase [EC:2.8.4.2] 129.0 13.0 0.0 1.0 1.0 T 1.0 12.0 1.0 1.0 COG0394 Protein-tyrosine-phosphatase Wzb 13.0 0.0769230769230769 0.9230769230769232 0.002460290881224 0.0071341261317492 0.0047972085064866 0.0046738352505252 0 0 0 0 K18702 0.08 0.0826210826210826 uctC; CoA:oxalate CoA-transferase [EC:2.8.3.19] 331.0 78.0 0.0 1.0 1.0 C 30.0 48.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 78.0 0.3846153846153846 0.6153846153846154 0.444177796832814 0.288505593553085 0.3663416951929495 0.1556722032797289 0 0 0 0 K18704 0.0142857142857142 0.0142450142450142 tarL; CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase [EC:2.7.8.14 2.7.8.47] path:map00552 Teichoic acid biosynthesis 143.0 10.0 9.0 2.0 0.909090909090909 M 6.0 5.0 2.0 0.818181818181818 COG1887 CDP-glycerol_glycerophosphotransferase,_TagB/SpsB_family TagB 11.0 0.5454545454545454 0.4545454545454545 0.0723740590366321 0.156204346194417 0.1142892026155245 0.0838302871577849 0 0 0 0 K18707 0.0057142857142857 0.5584045584045584 mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] 247.0 199.0 0.0 1.0 1.0 J 2.0 197.0 1.0 1.0 COG0621 tRNA_A37_methylthiotransferase_MiaB MiaB 199.0 0.0100502512562814 0.9899497487437184 0.9595437048494 0.952386086795388 0.955964895822394 0.0071576180540119 0 0 1 1 K18754 0.0 0.0028490028490028 LIN28; protein lin-28 144.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG1278 Cold_shock_protein,_CspA_family CspC 1.0 0.0 1.0 0 0 0 0 K18763 0.0028571428571428 0.0 LARP4; la-related protein 4 195.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 COG2039 Pyrrolidone-carboxylate_peptidase_(N-terminal_pyroglutamyl_peptidase) Pcp 1.0 1.0 0.0 0 0 0 0 K18765 0.0 0.0142450142450142 csrD; RNase E specificity factor CsrD 332.0 5.0 0.0 1.0 1.0 T 0.0 5.0 2.0 0.8 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 5.0 0.0 1.0 0.0037232615910046 0.0090956214236586 0.0064094415073316 0.005372359832654 0 0 0 0 K18766 0.0 0.017094017094017 blaZ; beta-lactamase class A BlaZ [EC:3.5.2.6] path:map01501 beta-Lactam resistance 154.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 6.0 0.0 1.0 0.0317087964858609 0.197549296721605 0.1146290466037329 0.1658405002357441 0 0 0 0 K18767 0.0 0.0085470085470085 blaCTX-M; beta-lactamase class A CTX-M [EC:3.5.2.6] path:map01501 beta-Lactam resistance 45.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 3.0 0.0 1.0 0 0 0 0 K18768 0.0 0.0085470085470085 blaKPC; beta-lactamase class A KPC [EC:3.5.2.6] path:map01501 beta-Lactam resistance 45.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 3.0 0.0 1.0 0 0 0 0 K18770 0.0 0.0142450142450142 pbpD; penicillin-binding protein 4 [EC:2.4.1.129 3.4.16.4] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 612.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 5.0 0.0 1.0 0.0153133685406376 0.0248756184173344 0.0200944934789859 0.0095622498766967 0 0 0 0 K18775 0.0 0.0028490028490028 lf2; levanbiose-producing levanase [EC:3.2.1.64] path:map00500 Starch and sucrose metabolism 517.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1621 Sucrose-6-phosphate_hydrolase_SacC,_GH32_family SacC 1.0 0.0 1.0 0 0 0 0 K18778 0.0 0.0512820512820512 zapD; cell division protein ZapD 210.0 18.0 0.0 1.0 1.0 D 0.0 18.0 1.0 1.0 COG4582 Cell_division_protein_ZapD,_interacts_with_FtsZ ZapD 18.0 0.0 1.0 7.474823287962569e-12 5.09900164077976e-08 2.5498745615542784e-08 5.098254158450965e-08 0 0 0 0 K18779 0.7457142857142857 0.017094017094017 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48] 263.0 284.0 273.0 3.0 0.940397350993378 J 295.0 7.0 2.0 0.963576158940397 COG0343 Queuine/archaeosine_tRNA-ribosyltransferase Tgt 302.0 0.97682119205298 0.0231788079470198 0.680049368897222 0.811524459281739 0.7457869140894805 0.131475090384517 0 1 0 1 K18783 0.0 0.0028490028490028 E2.4.1.279; nigerose phosphorylase [EC:2.4.1.279] 625.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG1554 Kojibiose_phosphorylase_YcjT ATH1 2.0 0.0 1.0 0 0 0 0 K18785 0.0028571428571428 0.0683760683760683 mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320] 264.0 32.0 0.0 1.0 1.0 G 1.0 31.0 1.0 1.0 COG2152 Predicted_glycosyl_hydrolase,_GH43/DUF377_family 32.0 0.03125 0.96875 0.587725540389649 0.635515640362106 0.6116205903758775 0.0477900999724569 0 0 0 1 K18786 0.0 0.0227920227920227 E2.4.1.321; cellobionic acid phosphorylase [EC:2.4.1.321] 101.0 8.0 7.0 2.0 0.888888888888889 G 0.0 9.0 1.0 1.0 COG3459 Cellobiose_phosphorylase 9.0 0.0 1.0 0.0214534585673686 0.0396470863760291 0.0305502724716988 0.0181936278086605 0 0 0 0 K18787 0.0028571428571428 0.0028490028490028 ACL5; thermospermine synthase [EC:2.5.1.79] 105.0 2.0 0.0 1.0 1.0 E 1.0 1.0 1.0 1.0 COG0421 Spermidine_synthase_(polyamine_aminopropyltransferase) SpeE 2.0 0.5 0.5 0 0 0 0 K18788 0.0 0.0056980056980056 wbbD; UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase [EC:2.4.1.303] path:map00542 O-Antigen repeat unit biosynthesis 262.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 2.0 0.0 1.0 0 0 0 0 K18795 0.0 0.0085470085470085 blaCARB-1; beta-lactamase class A CARB-1, PSE family [EC:3.5.2.6] path:map01501 beta-Lactam resistance 38.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 3.0 0.0 1.0 0 0 0 0 K18798 0.0 0.0028490028490028 AFG1, LACE1; peroxisome-assembly ATPase [EC:3.6.4.7] 678.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1485 Cell_division_protein_ZapE_(Z_ring-associated_ATPase),_AFG1_superfamily ZapE 1.0 0.0 1.0 0 0 0 0 K18799 0.0 0.0056980056980056 wzxB, rfbX; O-antigen flippase 414.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 2.0 0.0 1.0 0 0 0 0 K18800 0.0 0.0541310541310541 ubiI; 2-polyprenylphenol 6-hydroxylase [EC:1.14.13.240] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 317.0 25.0 24.0 2.0 0.961538461538462 CH 0.0 26.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 26.0 0.0 1.0 0.0043247782873692 0.00786902213025 0.0060969002088096 0.0035442438428807 0 0 0 0 K18802 0.0 0.0028490028490028 DUG3; glutamine amidotransferase 285.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0121 Predicted_glutamine_amidotransferase_YafJ YafJ 1.0 0.0 1.0 0 0 0 0 K18814 0.0085714285714285 0.1823361823361823 ictB; putative inorganic carbon (hco3(-)) transporter 172.0 89.0 0.0 1.0 1.0 M 3.0 86.0 2.0 0.887640449438202 COG3307 O-antigen_ligase RfaL 89.0 0.0337078651685393 0.9662921348314608 0.527431888695863 0.965370231658512 0.7464010601771875 0.437938342962649 0 0 0 1 K18815 0.0085714285714285 0.074074074074074 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82] 44.0 28.0 24.0 2.0 0.875 K 3.0 29.0 3.0 0.71875 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 32.0 0.09375 0.90625 0.0232506273209128 0.093085254177742 0.0581679407493273 0.0698346268568292 0 0 0 0 K18816 0.0885714285714285 0.0797720797720797 aac6-I, aacA7; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82] 27.0 53.0 47.0 4.0 0.854838709677419 K 31.0 31.0 4.0 0.838709677419355 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 62.0 0.5 0.5 0.0425357257205743 0.188178443685359 0.1153570847029666 0.1456427179647847 0 0 0 0 K18817 0.0 0.0142450142450142 hph; hygromycin-B 4-O-kinase [EC:2.7.1.163] 285.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 5.0 0.0 1.0 0.0779352329765215 0.203643531058947 0.1407893820177342 0.1257082980824255 0 0 0 0 K18820 0.0 0.0028490028490028 agd31B; oligosaccharide 4-alpha-D-glucosyltransferase [EC:2.4.1.161] 807.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1501 Alpha-glucosidase/xylosidase,_GH31_family YicI 1.0 0.0 1.0 0 0 0 0 K18821 0.0 0.037037037037037 lipL; lipoyl amidotransferase [EC:2.3.1.200] path:map00785,path:map01100 Lipoic acid metabolism,Metabolic pathways 249.0 13.0 0.0 1.0 1.0 H 0.0 13.0 1.0 1.0 COG0095 Lipoate-protein_ligase_A LplA 13.0 0.0 1.0 0.0076217342684866 0.0105666970970448 0.0090942156827656 0.0029449628285581 0 0 0 0 K18824 0.0 0.0626780626780626 sul2; dihydropteroate synthase type 2 [EC:2.5.1.15] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 260.0 22.0 0.0 1.0 1.0 H 0.0 22.0 1.0 1.0 COG0294 Dihydropteroate_synthase FolP 22.0 0.0 1.0 0.0080956160592611 0.0073974706238304 0.0077465433415457 0.0006981454354306 0 0 0 0 K18827 0.04 0.094017094017094 wbdD; O-antigen chain-terminating bifunctional methyltransferase/kinase [EC:2.1.1.- 2.1.1.294 2.7.1.181] 53.0 27.0 8.0 5.0 0.473684210526316 Q 18.0 39.0 6.0 0.473684210526316 COG0500 SAM-dependent_methyltransferase SmtA 57.0 0.3157894736842105 0.6842105263157895 0.0269604003380291 0.269416576390769 0.148188488364399 0.2424561760527399 0 0 0 0 K18828 0.2285714285714285 0.1965811965811965 mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] 35.0 255.0 182.0 3.0 0.770392749244713 S 128.0 203.0 2.0 0.993957703927492 COG1487 Ribonuclease/mRNA_interferase_VapC,_contains_PIN_domain VapC 331.0 0.3867069486404834 0.6132930513595166 0.398867240178932 0.379177184737777 0.3890222124583545 0.0196900554411549 0 0 0 0 K18829 0.0 0.1196581196581196 mvpT, vapB; antitoxin VapB 23.0 38.0 33.0 5.0 0.745098039215686 S 0.0 67.0 5.0 0.805970149253731 COG4456 Virulence-associated_protein_VagC_(function_unknown) VagC 67.0 0.0 1.0 0.132742910863869 0.0543559510608258 0.0935494309623474 0.0783869598030432 0 0 0 0 K18830 0.0 0.0113960113960113 pezA; HTH-type transcriptional regulator / antitoxin PezA 66.0 4.0 0.0 1.0 1.0 K 0.0 4.0 3.0 0.5 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 4.0 0.0 1.0 0.903469968797042 0.352476926377215 0.6279734475871285 0.550993042419827 0 0 1 1 K18831 0.0 0.1965811965811965 higA; HTH-type transcriptional regulator / antitoxin HigA 33.0 125.0 124.0 2.0 0.992063492063492 K 0.0 122.0 5.0 0.634920634920635 COG5499 Antitoxin_component_HigA_of_the_HigAB_toxin-antitoxin_module,_contains_an_N-terminal_HTH_domain HigA 122.0 0.0 1.0 0.0089504217860536 0.0178260287148535 0.0133882252504535 0.0088756069287999 0 0 0 0 K18833 0.0 0.0113960113960113 cmr; MFS transporter, DHA3 family, multidrug efflux protein 386.0 2.0 1.0 3.0 0.5 S 0.0 4.0 1.0 1.0 COG2270 MFS-type_transporter_involved_in_bile_tolerance,_Atg22_family BtlA 4.0 0.0 1.0 0.0776799916749022 0.164828978998176 0.1212544853365391 0.0871489873232738 0 0 0 0 K18837 0.0 0.0056980056980056 cbtA; cytoskeleton-binding toxin CbtA and related proteins 104.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2C4I5 4.0 0.0 1.0 7.01792946575425e-08 1.28996150729428e-21 3.508964732877189e-08 7.017929465754121e-08 0 0 0 0 K18838 0.0 0.0056980056980056 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins 99.0 5.0 0.0 1.0 1.0 S 0.0 5.0 2.0 0.8 2BMAS 5.0 0.0 1.0 9.93411208035087e-14 3.2790605726716197e-18 4.9672199932040687e-14 9.933784174293602e-14 0 0 0 0 K18841 0.0 0.0313390313390313 chpB, chpBK; mRNA interferase ChpB [EC:3.1.-.-] 108.0 12.0 0.0 1.0 1.0 T 0.0 12.0 1.0 1.0 COG2337 mRNA-degrading_endonuclease_MazF,_toxin_component_of_the_MazEF_toxin-antitoxin_module MazF 12.0 0.0 1.0 0.0330543324280471 0.0482164823321757 0.0406354073801114 0.0151621499041286 0 0 0 0 K18842 0.02 0.0712250712250712 chpS, chpBI; antitoxin ChpS 46.0 22.0 10.0 3.0 0.628571428571429 T 9.0 26.0 2.0 0.657142857142857 COG2336 Antitoxin_component_MazE_of_the_MazEF_toxin-antitoxin_module MazE 35.0 0.2571428571428571 0.7428571428571429 0.435392264553876 0.217914570661213 0.3266534176075445 0.2174776938926629 0 0 0 0 K18843 0.0028571428571428 0.0484330484330484 hicB; antitoxin HicB 71.0 11.0 4.0 3.0 0.478260869565217 S 1.0 22.0 1.0 1.0 COG1598 Antitoxin_component_HicB_of_the_HicAB_toxin-antitoxin_system HicB 23.0 0.0434782608695652 0.9565217391304348 0.0121964064498639 0.0695686329020042 0.040882519675934 0.0573722264521402 0 0 0 0 K18844 0.0028571428571428 0.0313390313390313 aph, spcN; spectinomycin phosphotransferase 264.0 10.0 7.0 2.0 0.769230769230769 S 1.0 12.0 3.0 0.692307692307692 COG2334 Ser/Thr_protein_kinase_RdoA_involved_in_Cpx_stress_response,_MazF_antagonist SrkA 13.0 0.0769230769230769 0.9230769230769232 0.101926484098223 0.169262842042611 0.135594663070417 0.067336357944388 0 0 0 0 K18845 0.0457142857142857 0.0227920227920227 rmt, armA; 16S rRNA (guanine(1405)-N(7))-methyltransferase [EC:2.1.1.179] 178.0 20.0 15.0 3.0 0.740740740740741 H 16.0 11.0 3.0 0.740740740740741 2EU2Z 27.0 0.5925925925925926 0.4074074074074074 0.0090710478473846 0.0900488288685541 0.0495599383579693 0.0809777810211695 0 0 0 0 K18846 0.0028571428571428 0.0028490028490028 npmA; 16S rRNA (adenine(1408)-N(1))-methyltransferase [EC:2.1.1.180] 190.0 1.0 0.0 2.0 0.5 Q 1.0 1.0 2.0 0.5 COG0500 SAM-dependent_methyltransferase SmtA 2.0 0.5 0.5 0 0 0 0 K18847 0.0 0.0284900284900284 E2.2.1.8; fluorothreonine transaldolase [EC:2.2.1.8] 376.0 8.0 6.0 2.0 0.8 E 0.0 10.0 2.0 0.8 COG0112 Glycine/serine_hydroxymethyltransferase GlyA 10.0 0.0 1.0 0.0963027338848597 0.484505599340694 0.2904041666127768 0.3882028654558342 0 0 0 0 K18850 0.0 0.0683760683760683 ycfD; 50S ribosomal protein L16 3-hydroxylase [EC:1.14.11.47] 272.0 26.0 0.0 1.0 1.0 S 0.0 26.0 1.0 1.0 COG2850 Ribosomal_protein_L16_Arg81_hydroxylase,_contains_JmjC_domain RoxA 26.0 0.0 1.0 0.0038916172288503 0.0076137163618733 0.0057526667953618 0.003722099133023 0 0 0 0 K18851 0.0 0.0056980056980056 fbp; diacylglycerol O-acyltransferase / trehalose O-mycolyltransferase [EC:2.3.1.20 2.3.1.122] path:map00561,path:map00572,path:map01100 Glycerolipid metabolism,Arabinogalactan biosynthesis - Mycobacterium,Metabolic pathways 302.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG0627 S-formylglutathione_hydrolase_FrmB FrmB 6.0 0.0 1.0 6.30701481657243e-08 3.3904307109110097e-18 3.1535074084557375e-08 6.307014816233388e-08 0 0 0 0 K18853 0.1171428571428571 0.0 dmrX; dihydromethanopterin reductase (acceptor) [EC:1.5.99.15] path:map00790,path:map01240 Folate biosynthesis,Biosynthesis of cofactors 211.0 43.0 0.0 1.0 1.0 C 43.0 0.0 3.0 0.86046511627907 COG1036 Archaeal_flavoprotein AfpA 43.0 1.0 0.0 0.917765540219024 0.971397160335208 0.944581350277116 0.0536316201161839 0 0 1 1 K18855 0.3085714285714285 0.0085470085470085 E1.1.1.374; UDP-N-acetylglucosamine 3-dehydrogenase [EC:1.1.1.374] 228.0 111.0 103.0 3.0 0.888 S 122.0 3.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 125.0 0.976 0.024 0.860426205358196 0.9632152820386 0.911820743698398 0.1027890766804039 0 0 1 1 K18856 0.0 0.017094017094017 vanC, vanE, vanG; D-alanine---D-serine ligase [EC:6.3.2.35] path:map01502,path:map02020 Vancomycin resistance,Two-component system 344.0 6.0 0.0 1.0 1.0 F 0.0 6.0 1.0 1.0 COG1181 D-alanine-D-alanine_ligase_or_related_ATP-grasp_enzyme DdlA 6.0 0.0 1.0 0.0495373958529143 0.0747891855546983 0.0621632907038063 0.0252517897017839 0 0 0 0 K18859 0.0257142857142857 0.0 sdhD, frdD; succinate dehydrogenase subunit D path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 109.0 9.0 0.0 1.0 1.0 arCOG05375 9.0 1.0 0.0 0 0 0 0 K18860 0.0485714285714285 0.0028490028490028 sdhD, frdD; succinate dehydrogenase subunit D path:map00020,path:map00190,path:map00650,path:map00720,path:map01100,path:map01110,path:map01120,path:map01200 Citrate cycle (TCA cycle),Oxidative phosphorylation,Butanoate metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 90.0 18.0 0.0 1.0 1.0 C 17.0 1.0 1.0 1.0 COG2142 Succinate_dehydrogenase,_hydrophobic_anchor_subunit SdhD 18.0 0.9444444444444444 0.0555555555555555 0.923946907777962 0.804059996055447 0.8640034519167045 0.1198869117225149 0 0 1 1 K18861 0.0314285714285714 0.0 K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] path:map00720,path:map01100,path:map01120,path:map01200 Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 473.0 11.0 0.0 1.0 1.0 H 11.0 0.0 1.0 1.0 COG1541 Phenylacetate-coenzyme_A_ligase_PaaK,_adenylate-forming_domain_family PaaK 11.0 1.0 0.0 0.0040814091010849 0.0162887112624048 0.0101850601817448 0.0122073021613199 0 0 0 0 K18862 0.0 0.0028490028490028 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D 35.0 4.0 0.0 1.0 1.0 S 0.0 4.0 2.0 0.75 2AWZ3 4.0 0.0 1.0 1.24524476485018e-07 1.1519677358372e-17 6.226223824826883e-08 1.2452447647349834e-07 0 0 0 0 K18866 0.0 0.017094017094017 vanXY; zinc D-Ala-D-Ala dipeptidase/carboxypeptidase [EC:3.4.13.22 3.4.17.14] path:map00550,path:map01100,path:map01502,path:map02020 Peptidoglycan biosynthesis,Metabolic pathways,Vancomycin resistance,Two-component system 133.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG1876 LD-carboxypeptidase_LdcB,_LAS_superfamily LdcB 7.0 0.0 1.0 0.0385319470419392 0.094166381725203 0.0663491643835711 0.0556344346832638 0 0 0 0 K18876 0.0 0.0028490028490028 avrBs3; type III effector protein AvrBs3 path:map04626 Plant-pathogen interaction 148.0 1.0 0.0 1.0 1.0 NT 0.0 1.0 1.0 1.0 COG1357 Uncharacterized_conserved_protein_YjbI,_contains_pentapeptide_repeats YjbI 1.0 0.0 1.0 0 0 0 0 K18879 0.0 0.0028490028490028 xopD; type III effector protein XopD path:map04626 Plant-pathogen interaction 17.0 4.0 0.0 1.0 1.0 O 0.0 4.0 1.0 1.0 COG5160 Protease,_Ulp1_family ULP1 4.0 0.0 1.0 3.1113953070775297e-12 1.7707342548691102e-17 1.5557065072100393e-12 3.111377599734981e-12 0 0 0 0 K18882 0.7114285714285714 0.0 priL, pri2, priB; DNA primase large subunit path:map03030 DNA replication 108.0 260.0 0.0 1.0 1.0 L 260.0 0.0 1.0 1.0 COG2219 Eukaryotic-type_DNA_primase,_large_subunit PRI2 260.0 1.0 0.0 0.252285913213434 0.942275829644995 0.5972808714292145 0.689989916431561 0 0 0 0 K18887 0.0 0.0199430199430199 efrA, efrE; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 572.0 11.0 0.0 1.0 1.0 V 0.0 11.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 11.0 0.0 1.0 0.0049436652048021 0.0108886139672452 0.0079161395860236 0.0059449487624431 0 0 0 0 K18888 0.0 0.0227920227920227 efrB, efrF; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 573.0 11.0 0.0 1.0 1.0 V 0.0 11.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 11.0 0.0 1.0 0.0053878727140347 0.0186558607417361 0.0120218667278854 0.0132679880277014 0 0 0 0 K18889 0.0085714285714285 0.3618233618233618 mdlA, smdA; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 443.0 136.0 126.0 2.0 0.931506849315068 V 3.0 143.0 2.0 0.986301369863014 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 146.0 0.0205479452054794 0.9794520547945206 0.0393938537888257 0.0090847243089053 0.0242392890488655 0.0303091294799204 0 0 0 0 K18890 0.0457142857142857 0.3618233618233618 mdlB, smdB; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 462.0 159.0 150.0 2.0 0.946428571428571 V 19.0 149.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 168.0 0.1130952380952381 0.8869047619047619 0.782425511396657 0.998275411727671 0.890350461562164 0.215849900331014 1 1 1 1 K18891 0.0 0.0113960113960113 patA, rscA, lmrC, satA; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 571.0 4.0 0.0 1.0 1.0 V 0.0 4.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 4.0 0.0 1.0 2.1505134577736e-12 1.72788455431566e-08 8.640498028307187e-09 1.727669502969883e-08 0 0 0 0 K18892 0.0 0.0028490028490028 patB, rscB, lmrC, satB; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 593.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 1.0 0.0 1.0 0 0 0 0 K18893 0.0 0.1139601139601139 vcaM; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 492.0 48.0 43.0 2.0 0.905660377358491 V 0.0 53.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 53.0 0.0 1.0 0.0043888625357956 0.505139165151462 0.2547640138436288 0.5007503026156663 0 0 0 0 K18894 0.0 0.0028490028490028 K18894; ATP-binding cassette, subfamily B, multidrug efflux pump path:map02010 ABC transporters 1252.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 1.0 0.0 1.0 0 0 0 0 K18896 0.0085714285714285 0.0712250712250712 gsmt; glycine/sarcosine N-methyltransferase [EC:2.1.1.156] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 169.0 10.0 3.0 7.0 0.32258064516129 J 4.0 27.0 6.0 0.451612903225806 COG0500 SAM-dependent_methyltransferase SmtA 31.0 0.1290322580645161 0.8709677419354839 0.387311042142604 0.731713366065179 0.5595122041038915 0.344402323922575 0 0 0 0 K18897 0.0085714285714285 0.0512820512820512 sdmt; sarcosine/dimethylglycine N-methyltransferase [EC:2.1.1.157] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 218.0 12.0 8.0 5.0 0.5 M 3.0 20.0 4.0 0.583333333333333 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 23.0 0.1304347826086956 0.8695652173913043 0.0452800350417047 0.114975195874418 0.0801276154580613 0.0696951608327133 0 0 0 0 K18898 0.0 0.0028490028490028 mdtE; membrane fusion protein, multidrug efflux system 385.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 1.0 0.0 1.0 0 0 0 0 K18899 0.0 0.0028490028490028 mdtF; multidrug efflux pump 1037.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 1.0 0.0 1.0 0 0 0 0 K18900 0.0 0.0085470085470085 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC 300.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.010461703874814 0.0226128625567794 0.0165372832157967 0.0121511586819654 0 0 0 0 K18901 0.0 0.0541310541310541 bpeE; membrane fusion protein, multidrug efflux system 233.0 24.0 0.0 1.0 1.0 M 0.0 24.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 24.0 0.0 1.0 0.0189074986724876 0.0403414260719714 0.0296244623722295 0.0214339273994838 0 0 0 0 K18902 0.0 0.037037037037037 bpeF; multidrug efflux pump 1035.0 9.0 4.0 2.0 0.642857142857143 V 0.0 14.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 14.0 0.0 1.0 0.0101794759916248 0.0219056224208666 0.0160425492062457 0.0117261464292418 0 0 0 0 K18903 0.0 0.037037037037037 oprC, opcM; outer membrane protein, multidrug efflux system 427.0 12.0 8.0 2.0 0.75 MU 0.0 16.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 16.0 0.0 1.0 0.0233659072215688 0.0382170587173857 0.0307914829694772 0.0148511514958168 0 0 0 0 K18904 0.0 0.0056980056980056 nodT, ameC; outer membrane protein, multidrug efflux system 458.0 2.0 0.0 1.0 1.0 MU 0.0 2.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 2.0 0.0 1.0 0 0 0 0 K18905 0.0 0.0028490028490028 ameR, rmiR; TetR/AcrR family transcriptional regulator, repressor of the ameABC operon 200.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K18906 0.0 0.0085470085470085 mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA 93.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 4.0 0.0 1.0 4.31164950949731e-08 1.76075764480703e-05 8.825346471582636e-06 1.7564459952975328e-05 0 0 0 0 K18907 0.0 0.0227920227920227 norG; GntR family transcriptional regulator, regulator for abcA and norABC 454.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG1167 DNA-binding_transcriptional_regulator,_MocR_family,_contains_an_aminotransferase_domain ARO8 10.0 0.0 1.0 0.0136337720577739 0.0400330124003573 0.0268333922290656 0.0263992403425834 0 0 0 0 K18908 0.0 0.017094017094017 mepA; multidrug efflux pump 434.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG0534 Na+-driven_multidrug_efflux_pump,_DinF/NorM/MATE_family NorM 6.0 0.0 1.0 0.0254475224262971 0.0790768408288151 0.052262181627556 0.053629318402518 0 0 0 0 K18909 0.0 0.0056980056980056 mepR; MarR family transcriptional regulator, repressor for mepA 145.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 2.0 0.0 1.0 0 0 0 0 K18910 0.04 0.094017094017094 dpe, lre; D-psicose/D-tagatose/L-ribulose 3-epimerase [EC:5.1.3.30 5.1.3.31] 159.0 54.0 0.0 1.0 1.0 G 16.0 38.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 54.0 0.2962962962962963 0.7037037037037037 0.106189948616178 0.632033228159472 0.369111588387825 0.525843279543294 0 0 0 0 K18911 0.0228571428571428 0.0769230769230769 egtD; L-histidine Nalpha-methyltransferase [EC:2.1.1.44] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 255.0 35.0 0.0 1.0 1.0 S 8.0 27.0 1.0 1.0 COG4301 Uncharacterized_protein,_contains_predicted_SAM-dependent_methyltransferase_domain 35.0 0.2285714285714285 0.7714285714285715 0.0110767497230529 0.301625204247294 0.1563509769851734 0.2905484545242411 0 0 0 0 K18912 0.0 0.1196581196581196 egtB; gamma-glutamyl hercynylcysteine S-oxide synthase [EC:1.14.99.50] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 138.0 31.0 19.0 6.0 0.53448275862069 S 0.0 58.0 3.0 0.913793103448276 COG1262 Formylglycine-generating_enzyme,_required_for_sulfatase_activity,_contains_SUMF1/FGE_domain YfmG 58.0 0.0 1.0 0.0075805348584566 0.022720079878747 0.0151503073686018 0.0151395450202903 0 0 0 0 K18913 0.0 0.0113960113960113 egtE; hercynylcysteine S-oxide lyase [EC:4.4.1.36] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 314.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 4.0 0.0 1.0 2.53112638849918e-06 1.55597363707274e-07 1.343361876103227e-06 2.375529024791906e-06 0 0 0 0 K18915 0.0542857142857142 0.0056980056980056 feR; ferric-chelate reductase [NAD(P)H] [EC:1.16.1.10] 150.0 12.0 1.0 2.0 0.521739130434783 S 20.0 3.0 2.0 0.826086956521739 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 23.0 0.8695652173913043 0.1304347826086956 0.0363235852934791 0.154622896308075 0.095473240800777 0.1182993110145959 0 0 0 0 K18916 0.0 0.0341880341880341 ptxD; phosphonate dehydrogenase [EC:1.20.1.1] 314.0 9.0 5.0 2.0 0.692307692307692 CH 0.0 13.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 13.0 0.0 1.0 0.0863053023444953 0.211697627871639 0.1490014651080671 0.1253923255271437 0 0 0 0 K18917 0.0 0.0826210826210826 mrx1; mycoredoxin [EC:1.20.4.3] 70.0 32.0 0.0 1.0 1.0 O 0.0 32.0 1.0 1.0 COG0695 Glutaredoxin GrxC 32.0 0.0 1.0 0.0216998073940079 0.589036454013869 0.3053681307039384 0.567336646619861 0 0 0 0 K18918 0.0057142857142857 0.0826210826210826 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB 63.0 20.0 6.0 3.0 0.465116279069767 S 3.0 43.0 5.0 0.739130434782609 COG4710 Predicted_DNA-binding_protein_with_an_HTH_domain 46.0 0.0652173913043478 0.9347826086956522 0.0138576140049276 0.0256729520372337 0.0197652830210806 0.0118153380323061 0 0 0 0 K18919 0.0 0.0056980056980056 hokC_D; protein HokC/D 43.0 4.0 0.0 1.0 1.0 S 0.0 4.0 2.0 0.75 2EFY7 4.0 0.0 1.0 7.01792946575425e-08 1.28996150729428e-21 3.508964732877189e-08 7.017929465754121e-08 0 0 0 0 K18920 0.0 0.0056980056980056 hokA; protein HokA 43.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2EFY7 3.0 0.0 1.0 0 0 0 0 K18921 0.0 0.0056980056980056 hokB; protein HokB 49.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2EFY7 2.0 0.0 1.0 0 0 0 0 K18922 0.0 0.0028490028490028 hokE; protein HokE 83.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2ECM3 1.0 0.0 1.0 0 0 0 0 K18923 0.0 0.0455840455840455 stbD; antitoxin StbD 78.0 14.0 12.0 2.0 0.875 D 0.0 17.0 3.0 0.823529411764706 COG2161 Antitoxin_component_YafN_of_the_YafNO_toxin-antitoxin_module,_PHD/YefM_family StbD 17.0 0.0 1.0 0.0620299752363937 0.11083999619429 0.0864349857153418 0.0488100209578963 0 0 0 0 K18924 0.0 0.0199430199430199 ykkC; paired small multidrug resistance pump 106.0 8.0 7.0 2.0 0.888888888888889 P 0.0 9.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 9.0 0.0 1.0 0.0021363650834169 0.0151059303802585 0.0086211477318377 0.0129695652968416 0 0 0 0 K18925 0.0 0.0199430199430199 ykkD; paired small multidrug resistance pump 104.0 9.0 0.0 1.0 1.0 P 0.0 9.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 9.0 0.0 1.0 0.0104938373265201 0.0166083281777122 0.0135510827521161 0.0061144908511921 0 0 0 0 K18926 0.0085714285714285 0.0883190883190883 lmrB; MFS transporter, DHA2 family, lincomycin resistance protein 394.0 28.0 17.0 5.0 0.595744680851064 EGP 3.0 44.0 2.0 0.957446808510638 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 47.0 0.0638297872340425 0.9361702127659576 0 0 0 0 K18928 0.0 0.2621082621082621 lldE; L-lactate dehydrogenase complex protein LldE 208.0 101.0 0.0 1.0 1.0 C 0.0 101.0 1.0 1.0 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 101.0 0.0 1.0 0.0024968441373683 0.0560290289950877 0.029262936566228 0.0535321848577194 0 0 0 0 K18929 0.0142857142857142 0.2621082621082621 lldF; L-lactate dehydrogenase complex protein LldF 354.0 109.0 107.0 2.0 0.981981981981982 C 5.0 106.0 3.0 0.783783783783784 COG1139 L-lactate_utilization_protein_LutB,_contains_a_ferredoxin-type_domain LutB 111.0 0.045045045045045 0.954954954954955 0.0690406664004096 0.529699246166802 0.2993699562836058 0.4606585797663923 0 0 0 0 K18930 0.0371428571428571 0.1452991452991453 dld; D-lactate dehydrogenase path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 20.0 92.0 0.0 1.0 1.0 C 17.0 68.0 7.0 0.423913043478261 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 85.0 0.2 0.8 0.349656228434182 0.820140088903715 0.5848981586689486 0.470483860469533 0 0 0 0 K18931 0.4285714285714285 0.0056980056980056 ampp; AMP phosphorylase [EC:2.4.2.57] 425.0 172.0 0.0 1.0 1.0 F 170.0 2.0 1.0 1.0 COG0213 Thymidine_phosphorylase DeoA 172.0 0.9883720930232558 0.0116279069767441 0.992485126671642 0.991275049952499 0.9918800883120704 0.0012100767191429 0 0 1 1 K18933 0.3542857142857142 0.0227920227920227 mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11] path:map00350,path:map00410,path:map00680,path:map00770,path:map01100,path:map01110,path:map01240 Tyrosine metabolism,beta-Alanine metabolism,Methane metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 270.0 107.0 80.0 2.0 0.798507462686567 E 126.0 8.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 134.0 0.9402985074626866 0.0597014925373134 0.815352486267818 0.873604406343491 0.8444784463056545 0.058251920075673 1 1 1 1 K18934 0.0 0.0028490028490028 lmrS; MFS transporter, DHA2 family, multidrug resistance protein 462.0 1.0 0.0 1.0 1.0 EGP 0.0 1.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 1.0 0.0 1.0 0 0 0 0 K18935 0.0028571428571428 0.0085470085470085 sdrM; MFS transporter, DHA2 family, multidrug resistance protein 432.0 3.0 2.0 2.0 0.75 EGP 1.0 3.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 4.0 0.25 0.75 0 0 0 0 K18936 0.0 0.0028490028490028 mdeA; MFS transporter, DHA2 family, multidrug resistance protein 481.0 1.0 0.0 1.0 1.0 EGP 0.0 1.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 1.0 0.0 1.0 0 0 0 0 K18937 0.0 0.0028490028490028 lfrR; TetR/AcrR family transcriptional regulator, repressor for lfrA 190.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 2.0 0.0 1.0 0 0 0 0 K18939 0.0542857142857142 0.0284900284900284 lmrA, yxaF; TetR/AcrR family transcriptional regulator, lmrAB and yxaGH operons repressor 91.0 33.0 0.0 1.0 1.0 K 23.0 10.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 33.0 0.696969696969697 0.303030303030303 0.0604726219716208 0.0592965589543394 0.0598845904629801 0.0011760630172814 0 0 0 0 K18940 0.0 0.0227920227920227 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] path:map02020 Two-component system 425.0 8.0 0.0 1.0 1.0 T 0.0 8.0 2.0 0.875 COG5002 Sensor_histidine_kinase_WalK WalK 8.0 0.0 1.0 0.0018538861747176 5.05958503878548e-08 0.0009269683852839 0.0018538355788672 0 0 0 0 K18941 0.0 0.0284900284900284 arlR; two-component system, OmpR family, response regulator ArlR path:map02020 Two-component system 212.0 11.0 10.0 2.0 0.916666666666667 K 0.0 12.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 12.0 0.0 1.0 2.77917235197463e-12 0.016496977740951 0.008248488871865 0.0164969777381718 0 0 0 0 K18953 0.0028571428571428 0.0 NSMAF, FAN; factor associated with neutral sphingomyelinase activation path:map04071 Sphingolipid signaling pathway 300.0 1.0 0.0 1.0 1.0 TU 1.0 0.0 1.0 1.0 KOG1786 1.0 1.0 0.0 0 0 0 0 K18954 0.0 0.0712250712250712 pobR; AraC family transcriptional regulator, transcriptional activator of pobA 130.0 32.0 31.0 3.0 0.941176470588235 K 0.0 34.0 3.0 0.852941176470588 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 34.0 0.0 1.0 0.0349264001986812 0.0413029557038708 0.038114677951276 0.0063765555051895 0 0 0 0 K18955 0.0 0.0797720797720797 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator 59.0 125.0 123.0 2.0 0.984251968503937 K 0.0 127.0 4.0 0.748031496062992 2CC1Y 127.0 0.0 1.0 0.0007809433126695 0.002081587871024 0.0014312655918467 0.0013006445583545 0 0 0 0 K18957 0.0 0.0028490028490028 whiB6; WhiB family transcriptional regulator, redox-sensing transcriptional regulator 97.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2AJEQ 1.0 0.0 1.0 0 0 0 0 K18958 0.0 0.0541310541310541 whiB7; WhiB family transcriptional regulator, redox-sensing transcriptional regulator 68.0 22.0 21.0 2.0 0.956521739130435 K 0.0 23.0 2.0 0.956521739130435 2DMIS 23.0 0.0 1.0 0.0025239858796026 0.0059850820053393 0.0042545339424709 0.0034610961257367 0 0 0 0 K18966 0.0 0.0085470085470085 GADL1, CSAD; sulfinoalanine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.29 4.1.1.11] path:map00410,path:map00430,path:map00770,path:map01100,path:map01110 beta-Alanine metabolism,Taurine and hypotaurine metabolism,Pantothenate and CoA biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 456.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 3.0 0.0 1.0 0 0 0 0 K18967 0.0 0.0712250712250712 dge1; diguanylate cyclase [EC:2.7.7.65] 85.0 31.0 30.0 2.0 0.96875 T 0.0 32.0 7.0 0.6875 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 32.0 0.0 1.0 0.466452404379702 0.353307831727007 0.4098801180533545 0.1131445726526949 0 0 0 0 K18968 0.0 0.0199430199430199 adrA; diguanylate cyclase [EC:2.7.7.65] path:map02026 Biofilm formation - Escherichia coli 333.0 7.0 0.0 1.0 1.0 T 0.0 7.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 7.0 0.0 1.0 0.0164757951056844 0.0399843465049088 0.0282300708052966 0.0235085513992244 0 0 0 0 K18973 0.0 0.0028490028490028 blaOXA-50; beta-lactamase class D OXA-50 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 265.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 1.0 0.0 1.0 0 0 0 0 K18974 0.0 0.0142450142450142 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 263.0 4.0 3.0 2.0 0.8 H 0.0 5.0 2.0 0.8 COG0294 Dihydropteroate_synthase FolP 5.0 0.0 1.0 0.0437582919318097 0.159252215932085 0.1015052539319473 0.1154939240002753 0 0 0 0 K18975 0.0028571428571428 0.0056980056980056 ebr, qacEdelta1; small multidrug resistance pump 106.0 2.0 1.0 2.0 0.666666666666667 P 1.0 2.0 1.0 1.0 COG2076 Multidrug_transporter_EmrE_and_related_cation_transporters EmrE 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K18978 0.1342857142857142 0.0 gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90] path:map00010,path:map00030,path:map01100,path:map01120,path:map01200 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 434.0 52.0 0.0 1.0 1.0 C 52.0 0.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 52.0 1.0 0.0 0.0625553211996352 0.306501087350989 0.1845282042753121 0.2439457661513538 0 0 0 0 K18979 0.1 0.5156695156695157 queG; epoxyqueuosine reductase [EC:1.17.99.6] 105.0 229.0 222.0 4.0 0.9581589958159 C 46.0 193.0 5.0 0.928870292887029 COG1600 Epoxyqueuosine_reductase_QueG_(queuosine_biosynthesis) QueG 239.0 0.1924686192468619 0.8075313807531381 0.308000955461029 0.906653031904272 0.6073269936826505 0.598652076443243 0 0 0 0 K18981 0.0057142857142857 0.0598290598290598 udh; uronate dehydrogenase [EC:1.1.1.203] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 141.0 28.0 18.0 2.0 0.736842105263158 GM 2.0 36.0 2.0 0.973684210526316 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 38.0 0.0526315789473684 0.9473684210526316 0.0113488923486326 0.0232699832341487 0.0173094377913906 0.0119210908855161 0 0 0 0 K18982 0.0 0.0085470085470085 gli; D-galactarolactone isomerase [EC:5.4.1.4] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 267.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3618 Predicted_metal-dependent_hydrolase,_TIM-barrel_fold 3.0 0.0 1.0 0 0 0 0 K18983 0.0742857142857142 0.0313390313390313 gci; D-galactarolactone cycloisomerase [EC:5.5.1.27] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 252.0 44.0 0.0 1.0 1.0 M 31.0 13.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 44.0 0.7045454545454546 0.2954545454545454 0.133872456940455 0.211773934421935 0.172823195681195 0.07790147748148 0 0 0 0 K18986 0.0 0.0085470085470085 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] path:map02020 Two-component system 301.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 3.0 0.0 1.0 0 0 0 0 K18987 0.0 0.0056980056980056 irr; two-component system, OmpR family, response regulator Irr path:map02020 Two-component system 218.0 1.0 0.0 2.0 0.5 T 0.0 2.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 2.0 0.0 1.0 0 0 0 0 K18988 0.0028571428571428 0.0256410256410256 ampH; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase [EC:3.4.16.4 3.4.21.-] 284.0 10.0 9.0 2.0 0.909090909090909 V 2.0 9.0 2.0 0.909090909090909 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 11.0 0.1818181818181818 0.8181818181818182 2.86165887709626e-12 7.10030504547276e-12 4.9809819612845085e-12 4.2386461683765e-12 0 0 0 0 K18989 0.0 0.0569800569800569 vexF; multidrug efflux pump 969.0 21.0 0.0 1.0 1.0 V 0.0 21.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 21.0 0.0 1.0 0.0230660971094175 0.0716255522225559 0.0473458246659867 0.0485594551131384 0 0 0 0 K18990 0.0 0.0655270655270655 vexE; membrane fusion protein, multidrug efflux system 283.0 29.0 0.0 1.0 1.0 M 0.0 29.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 29.0 0.0 1.0 0.0096157028875519 0.0252828208294168 0.0174492618584843 0.0156671179418649 0 0 0 0 K18991 0.0 0.0199430199430199 mtrA; AraC family transcriptional regulator, activator of mtrCDE 112.0 5.0 4.0 3.0 0.714285714285714 K 0.0 7.0 4.0 0.428571428571429 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 7.0 0.0 1.0 0.0623375054651146 0.133719575004509 0.0980285402348118 0.0713820695393944 0 0 0 0 K18992 0.0 0.0028490028490028 cmeR; TetR/AcrR family transcriptional regulator, cmeABC operon repressor 212.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K18996 0.0 0.0427350427350427 repC; replication initiation protein RepC 86.0 21.0 12.0 3.0 0.67741935483871 K 0.0 28.0 4.0 0.419354838709677 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 28.0 0.0 1.0 0.0025282092267603 0.0053208939293518 0.003924551578056 0.0027926847025915 0 0 0 0 K18997 0.0 0.0712250712250712 cbpM; chaperone modulatory protein CbpM 54.0 23.0 21.0 2.0 0.92 K 0.0 25.0 3.0 0.88 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 25.0 0.0 1.0 0.0099865043381453 0.0586153339430954 0.0343009191406203 0.0486288296049501 0 0 0 0 K19000 0.0 0.0313390313390313 rof; Rho-binding antiterminator 65.0 9.0 7.0 2.0 0.818181818181818 K 0.0 11.0 2.0 0.818181818181818 COG4568 Transcriptional_antiterminator_Rof_(Rho-off) Rof 11.0 0.0 1.0 0.0129438489091759 0.0286247349855351 0.0207842919473555 0.0156808860763592 0 0 0 0 K19002 0.0942857142857142 0.1709401709401709 mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] path:map00552,path:map00561,path:map01100 Teichoic acid biosynthesis,Glycerolipid metabolism,Metabolic pathways 46.0 82.0 61.0 3.0 0.788461538461538 M 37.0 67.0 2.0 0.798076923076923 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 104.0 0.3557692307692308 0.6442307692307693 0.895200056659624 0.742307035940066 0.818753546299845 0.152893020719558 1 1 1 1 K19003 0.1057142857142857 0.0797720797720797 mgdA; 1,2-diacylglycerol 3-beta-glucosyltransferase [EC:2.4.1.336] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 186.0 70.0 69.0 2.0 0.985915492957746 M 40.0 31.0 2.0 0.985915492957746 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 71.0 0.5633802816901409 0.4366197183098591 0.0452235482510169 0.158357723761722 0.1017906360063694 0.113134175510705 0 0 0 0 K19005 0.0 0.0398860398860398 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] path:map00552,path:map00561,path:map01100 Teichoic acid biosynthesis,Glycerolipid metabolism,Metabolic pathways 571.0 18.0 0.0 1.0 1.0 M 0.0 18.0 1.0 1.0 COG1368 Phosphoglycerol_transferase_MdoB/OpgB,_AlkP_superfamily MdoB 18.0 0.0 1.0 0.0086420156848334 0.0082087863730123 0.0084254010289228 0.000433229311821 0 0 0 0 K19032 0.0 0.037037037037037 PSRP3; 30S ribosomal protein 3 99.0 13.0 0.0 1.0 1.0 J 0.0 13.0 1.0 1.0 2C5W0 13.0 0.0 1.0 3.72209227009939e-12 0.001060783735677 0.0005303918696995 0.0010607837319549 0 0 0 0 K19033 0.0 0.0142450142450142 PSRP4, RPS31; 30S ribosomal protein S31 42.0 3.0 0.0 1.0 1.0 S 0.0 5.0 4.0 0.4 2ABSQ 5.0 0.0 1.0 0.0084469029531992 0.0203032189460915 0.0143750609496453 0.0118563159928923 0 0 0 0 K19046 0.0285714285714285 0.0997150997150997 casB, cse2; CRISPR system Cascade subunit CasB 65.0 44.0 43.0 2.0 0.977777777777778 S 10.0 36.0 14.0 0.282608695652174 2DP12 46.0 0.217391304347826 0.782608695652174 0.154198926802806 0.218476736753576 0.186337831778191 0.06427780995077 0 0 0 0 K19047 0.0 0.0056980056980056 tetC; TetR/AcrR family transcriptional regulator, repressor of tetCD 186.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 3.0 0.0 1.0 0 0 0 0 K19048 0.0028571428571428 0.0227920227920227 symE; toxic protein SymE 53.0 8.0 5.0 3.0 0.666666666666667 S 1.0 11.0 6.0 0.25 COG3677 Transposase_InsA InsA 12.0 0.0833333333333333 0.9166666666666666 0.0715790249481102 0.0493202017231072 0.0604496133356087 0.022258823225003 0 0 0 0 K19049 0.0 0.0341880341880341 cslA; chondroitin AC lyase [EC:4.2.2.5] 253.0 16.0 11.0 3.0 0.727272727272727 N 0.0 22.0 7.0 0.545454545454545 COG5492 Uncharacterized_conserved_protein_YjdB,_contains_Ig-like_domain YjdB 22.0 0.0 1.0 0.253399230549066 0.0242136897289812 0.1388064601390236 0.2291855408200848 0 0 0 0 K19051 0.0 0.0056980056980056 hepB; heparin/heparan-sulfate lyase [EC:4.2.2.7 4.2.2.8] 562.0 7.0 0.0 1.0 1.0 S 0.0 8.0 1.0 1.0 COG5652 VanZ-like_family_protein_(function_unknown) VanZ 8.0 0.0 1.0 0.0004246870765039 9.38684734425084e-13 0.0002123435387212 0.0004246870755652 0 0 0 0 K19052 0.0 0.0028490028490028 hepC; heparan-sulfate lyase [EC:4.2.2.8] 716.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG5434 Polygalacturonase Pgu1 1.0 0.0 1.0 0 0 0 0 K19054 0.0 0.0028490028490028 FXN; frataxin [EC:1.16.3.1] path:map00860 Porphyrin metabolism 110.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG1965 Fe-S_cluster_assembly_protein_CyaY,_frataxin_homolog CyaY 1.0 0.0 1.0 0 0 0 0 K19055 0.0628571428571428 0.2108262108262108 prdX, proX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-] 76.0 104.0 100.0 3.0 0.928571428571429 S 24.0 88.0 3.0 0.535714285714286 COG2606 Cys-tRNA(Pro)_deacylase,_prolyl-tRNA_editing_enzyme_YbaK/EbsC EbsC 112.0 0.2142857142857142 0.7857142857142857 0.0188199732141648 0.129439052958843 0.0741295130865039 0.1106190797446782 0 0 0 0 K19056 0.0 0.0056980056980056 tetD; AraC family transcriptional regulator, transposon Tn10 TetD protein 140.0 5.0 0.0 1.0 1.0 K 0.0 5.0 2.0 0.6 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 5.0 0.0 1.0 0.0032872913918945 1.50085827596754e-12 0.0016436456966976 0.0032872913903936 0 0 0 0 K19057 0.0 0.0113960113960113 merD; MerR family transcriptional regulator, mercuric resistance operon regulatory protein 70.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 4.0 0.0 1.0 0.0453996143563289 0.10711227013568 0.0762559422460044 0.0617126557793511 0 0 0 0 K19058 0.0 0.0284900284900284 merC; mercuric ion transport protein 68.0 11.0 0.0 1.0 1.0 S 0.0 11.0 2.0 0.818181818181818 2E3VI 11.0 0.0 1.0 0.0324411973326408 0.0770257922632093 0.054733494797925 0.0445845949305684 0 0 0 0 K19059 0.0 0.0056980056980056 merE; mercuric ion transport protein 78.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2C8CA 2.0 0.0 1.0 0 0 0 0 K19062 0.0 0.0113960113960113 arr; rifampin ADP-ribosylating transferase 90.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 2DK0G 4.0 0.0 1.0 0.0650834497126146 0.127586318525826 0.0963348841192203 0.0625028688132114 0 0 0 0 K19064 0.0742857142857142 0.0484330484330484 lysDH; lysine 6-dehydrogenase [EC:1.4.1.18] path:map00960,path:map01100,path:map01110 Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 236.0 50.0 49.0 2.0 0.980392156862745 E 33.0 18.0 1.0 1.0 COG1748 Saccharopine_dehydrogenase,_NADP-dependent Lys9 51.0 0.6470588235294118 0.3529411764705882 0.523087600034035 0.772289836254358 0.6476887181441965 0.249202236220323 0 1 0 1 K19065 0.0 0.0028490028490028 mobA; 3-hydroxybenzoate 4-monooxygenase [EC:1.14.13.23] path:map00362,path:map00624,path:map01220 Benzoate degradation,Polycyclic aromatic hydrocarbon degradation,Degradation of aromatic compounds 639.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K19066 0.0 0.0085470085470085 E1.3.8.10; cyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.3.8.10] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 378.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 5.0 0.0 1.0 1.1758669437268e-06 0.0007129320219081 0.0003570539444259 0.0007117561549643 0 0 0 0 K19067 0.0 0.0085470085470085 E1.3.8.11; cyclohexane-1-carbonyl-CoA dehydrogenase [EC:1.3.8.11] path:map00362,path:map01100,path:map01120 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments 378.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 5.0 0.0 1.0 1.1554953100478e-06 0.0007048337263415 0.0003529946108257 0.0007036782310314 0 0 0 0 K19068 0.0085714285714285 0.0598290598290598 wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367] path:map00541,path:map01100,path:map01250 O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 307.0 18.0 11.0 2.0 0.72 GM 3.0 22.0 2.0 0.84 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 25.0 0.12 0.88 0.133318954620425 0.813288107576633 0.4733035310985289 0.679969152956208 0 0 0 0 K19070 0.0257142857142857 0.017094017094017 oorA; oxalate oxidoreductase subunit alpha [EC:1.2.7.10] 374.0 17.0 0.0 1.0 1.0 C 9.0 8.0 1.0 1.0 COG0674 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_alpha_subunit PorA 17.0 0.5294117647058824 0.4705882352941176 0.0290222993964067 0.0370075874824414 0.033014943439424 0.0079852880860347 0 0 0 0 K19071 0.0057142857142857 0.017094017094017 oorB; oxalate oxidoreductase subunit beta [EC:1.2.7.10] 291.0 9.0 0.0 1.0 1.0 C 2.0 7.0 1.0 1.0 COG1013 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_beta_subunit PorB 9.0 0.2222222222222222 0.7777777777777778 0.493268487725458 0.306044043082534 0.399656265403996 0.1872244446429239 0 0 0 0 K19072 0.0028571428571428 0.0199430199430199 oorD; oxalate oxidoreductase subunit delta [EC:1.2.7.10] 80.0 8.0 0.0 1.0 1.0 C 1.0 7.0 2.0 0.5 COG1014 Pyruvate:ferredoxin_oxidoreductase_or_related_2-oxoacid:ferredoxin_oxidoreductase,_gamma_subunit PorG 8.0 0.125 0.875 0.526840167521389 0.393328119772558 0.4600841436469735 0.1335120477488309 0 0 0 1 K19073 0.0 0.0256410256410256 DVR; divinyl chlorophyllide a 8-vinyl-reductase [EC:1.3.1.75] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 191.0 9.0 7.0 2.0 0.818181818181818 GM 0.0 11.0 2.0 0.909090909090909 COG0702 Uncharacterized_conserved_protein_YbjT,_contains_NAD(P)-binding_and_DUF2867_domains YbjT 11.0 0.0 1.0 0.0314213295297296 0.0630228433799297 0.0472220864548296 0.0316015138502 0 0 0 0 K19074 0.1 0.0 csa2; CRISPR-associated protein Csa2 256.0 33.0 28.0 2.0 0.868421052631579 V 38.0 0.0 1.0 1.0 COG1857 CRISPR-Cas_system_type_I_effector_complex_subunit_Cas7,__RAMP_superfamily Cas7 38.0 1.0 0.0 0.375565860483735 0.797901386877498 0.5867336236806165 0.422335526393763 0 0 0 0 K19075 0.1257142857142857 0.1225071225071225 cst2, cas7; CRISPR-associated protein Cst2 91.0 63.0 19.0 2.0 0.588785046728972 L 57.0 50.0 1.0 1.0 COG1857 CRISPR-Cas_system_type_I_effector_complex_subunit_Cas7,__RAMP_superfamily Cas7 107.0 0.5327102803738317 0.4672897196261682 0.974469600584048 0.98726912067769 0.9808693606308688 0.012799520093642 1 1 1 1 K19076 0.1114285714285714 0.1396011396011396 cmr2, cas10; CRISPR-associated protein Cmr2 38.0 59.0 26.0 4.0 0.483606557377049 S 47.0 73.0 3.0 0.795081967213115 COG1353 CRISPR/Cas_system-associated_protein_Cas10,_large_subunit_of_type_III_CRISPR-Cas_systems,_contains_HD_superfamily_nuclease_domain Cas10 120.0 0.3916666666666666 0.6083333333333333 0.670779130051603 0.921389215361687 0.796084172706645 0.2506100853100841 0 1 0 1 K19077 0.0 0.017094017094017 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3] path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 328.0 6.0 0.0 1.0 1.0 T 0.0 6.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 6.0 0.0 1.0 2.29899295574556e-12 4.46915098184248e-08 2.2346904405690272e-08 4.4689210825469055e-08 0 0 0 0 K19078 0.0 0.0113960113960113 graR; two-component system, OmpR family, response regulator protein GraR path:map01503,path:map02020 Cationic antimicrobial peptide (CAMP) resistance,Two-component system 223.0 2.0 1.0 3.0 0.5 KT 0.0 4.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 4.0 0.0 1.0 8.05929869138541e-06 4.48547887565566e-06 6.272388783520535e-06 3.573819815729751e-06 0 0 0 0 K19079 0.0 0.0113960113960113 vraF; cationic antimicrobial peptide transport system ATP-binding protein path:map01503,path:map02010,path:map02020,path:map05150 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters,Two-component system,Staphylococcus aureus infection 251.0 4.0 0.0 1.0 1.0 V 0.0 4.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 4.0 0.0 1.0 1.69853056771476e-05 1.1442216284322e-05 1.42137609807348e-05 5.5430893928256e-06 0 0 0 0 K19080 0.0 0.0142450142450142 vraG; cationic antimicrobial peptide transport system permease protein path:map01503,path:map02010,path:map02020,path:map05150 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters,Two-component system,Staphylococcus aureus infection 634.0 5.0 0.0 1.0 1.0 V 0.0 5.0 1.0 1.0 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 5.0 0.0 1.0 1.45922281391279e-07 7.69639428376781e-07 4.5778085488403e-07 6.23717146985502e-07 0 0 0 0 K19081 0.0 0.0199430199430199 braS, bceS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3] path:map02020 Two-component system 295.0 8.0 0.0 1.0 1.0 T 0.0 8.0 1.0 1.0 COG0642 Signal_transduction_histidine_kinase BaeS 8.0 0.0 1.0 0.00354401255428 0.0066208219104793 0.0050824172323796 0.0030768093561993 0 0 0 0 K19082 0.0 0.037037037037037 braR, bceR; two-component system, OmpR family, response regulator protein BraR/BceR path:map02020 Two-component system 211.0 9.0 5.0 3.0 0.642857142857143 T 0.0 14.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 14.0 0.0 1.0 0.0054132115829105 0.011303167883471 0.0083581897331907 0.0058899563005605 0 0 0 0 K19083 0.0 0.017094017094017 braD, bceA; bacitracin transport system ATP-binding protein path:map02010,path:map02020 ABC transporters,Two-component system 254.0 6.0 0.0 1.0 1.0 V 0.0 6.0 1.0 1.0 COG1136 ABC-type_lipoprotein_export_system,_ATPase_component LolD 6.0 0.0 1.0 0.0074665087658136 0.0173963513302131 0.0124314300480133 0.0099298425643995 0 0 0 0 K19084 0.0 0.0113960113960113 braE, bceB; bacitracin transport system permease protein path:map02010,path:map02020 ABC transporters,Two-component system 555.0 5.0 0.0 1.0 1.0 V 0.0 5.0 1.0 1.0 COG0577 ABC-type_antimicrobial_peptide_transport_system,_permease_component SalY 5.0 0.0 1.0 0.0458301662922034 0.114039780782589 0.0799349735373962 0.0682096144903856 0 0 0 0 K19085 0.12 0.0028490028490028 csa1; CRISPR-associated protein Csa1 144.0 41.0 33.0 3.0 0.732142857142857 V 55.0 1.0 2.0 0.928571428571429 COG4343 CRISPR/Cas_system-associated_exonuclease_Cas4,_RecB_family Cas4 56.0 0.9821428571428572 0.0178571428571428 0.631142994310088 0.874370888709434 0.752756941509761 0.243227894399346 0 0 0 1 K19086 0.0228571428571428 0.0 csa4, cas8a2; CRISPR-associated protein Csa4 244.0 7.0 3.0 2.0 0.636363636363636 V 11.0 0.0 1.0 1.0 arCOG01441 11.0 1.0 0.0 0.0238252725294469 0.0414906332133633 0.0326579528714051 0.0176653606839163 0 0 0 0 K19087 0.0542857142857142 0.0 csa5; CRISPR-associated protein Csa5 78.0 4.0 1.0 2.0 0.571428571428571 S 19.0 0.0 4.0 0.421052631578947 arCOG06143 19.0 1.0 0.0 0.166204519937399 0.303669857780668 0.2349371888590335 0.137465337843269 0 0 0 0 K19088 0.04 0.0598290598290598 cst1, cas8a; CRISPR-associated protein Cst1 181.0 21.0 8.0 2.0 0.617647058823529 S 14.0 23.0 6.0 0.378378378378378 arCOG05269 37.0 0.3783783783783784 0.6216216216216216 0.778057732870337 0.671592554687797 0.7248251437790669 0.1064651781825399 1 1 1 1 K19089 0.1142857142857142 0.0 cas5a_b_c; CRISPR-associated protein Cas5a/b/c 113.0 30.0 19.0 2.0 0.731707317073171 V 44.0 0.0 2.0 0.931818181818182 COG1688 CRISPR/Cas_system-associated_protein_Cas5,_RAMP_superfamily Cas5 44.0 1.0 0.0 0.30579849140273 0.77167138407643 0.53873493773958 0.4658728926736999 0 0 0 0 K19090 0.0628571428571428 0.0911680911680911 cas5t; CRISPR-associated protein Cas5t 81.0 36.0 23.0 3.0 0.620689655172414 L 22.0 36.0 3.0 0.844827586206897 COG1688 CRISPR/Cas_system-associated_protein_Cas5,_RAMP_superfamily Cas5 58.0 0.3793103448275862 0.6206896551724138 0.422807890996596 0.764275377943528 0.5935416344700619 0.3414674869469319 0 0 0 0 K19091 0.2228571428571428 0.2051282051282051 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] 37.0 93.0 21.0 5.0 0.440758293838863 L 98.0 114.0 3.0 0.767772511848341 COG1583 CRISPR/Cas_system_endoribonuclease_Cas6,_RAMP_superfamily Cas6 212.0 0.4622641509433962 0.5377358490566038 0.945415090160705 0.959173147723849 0.952294118942277 0.0137580575631439 1 1 1 1 K19092 0.0 0.168091168091168 parE1_3_4; toxin ParE1/3/4 35.0 80.0 44.0 2.0 0.689655172413793 S 0.0 117.0 1.0 1.0 COG3668 Plasmid_stabilization_system_protein_ParE ParE 117.0 0.0 1.0 0.0090494279088791 0.0219473251011342 0.0154983765050066 0.0128978971922551 0 0 0 0 K19093 0.0 0.0028490028490028 parE2; toxin ParE2 97.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG3668 Plasmid_stabilization_system_protein_ParE ParE 1.0 0.0 1.0 0 0 0 0 K19100 0.0 0.0085470085470085 blaDHA; beta-lactamase class C DHA [EC:3.5.2.6] path:map01501 beta-Lactam resistance 375.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 3.0 0.0 1.0 0 0 0 0 K19101 0.0 0.0085470085470085 blaFOX; beta-lactamase class C FOX [EC:3.5.2.6] path:map01501 beta-Lactam resistance 375.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 3.0 0.0 1.0 0 0 0 0 K19102 0.0 0.0028490028490028 nocA; nocardicin nonribosomal peptide synthetase NocA path:map00261,path:map01100,path:map01110 Monobactam biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 610.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 1.0 0.0 1.0 0 0 0 0 K19103 0.0 0.0085470085470085 nocB; nocardicin nonribosomal peptide synthetase NocB path:map00261,path:map01100,path:map01110 Monobactam biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 754.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K19104 0.0 0.0085470085470085 nat; isonocardicin synthase [EC:2.5.1.38] path:map00261,path:map01100,path:map01110 Monobactam biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 200.0 3.0 0.0 1.0 1.0 FG 0.0 3.0 1.0 1.0 COG4106 Trans-aconitate_methyltransferase Tam 3.0 0.0 1.0 0 0 0 0 K19105 0.0028571428571428 0.0085470085470085 nocJ; nocardicin-A epimerase [EC:5.1.1.14] path:map00261,path:map01100,path:map01110 Monobactam biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 105.0 4.0 0.0 1.0 1.0 E 1.0 3.0 1.0 1.0 COG2515 1-aminocyclopropane-1-carboxylate_deaminase/D-cysteine_desulfhydrase,_PLP-dependent_ACC_family Acd 4.0 0.25 0.75 0.108150828454817 0.252963259167523 0.18055704381117 0.144812430712706 0 0 0 0 K19113 0.0 0.0028490028490028 ttr; acetyltransferase [EC:2.3.1.-] path:map00261,path:map01110 Monobactam biosynthesis,Biosynthesis of secondary metabolites 172.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 1.0 0.0 1.0 0 0 0 0 K19114 0.04 0.0598290598290598 csh1; CRISPR-associated protein Csh1 168.0 31.0 25.0 2.0 0.837837837837838 S 19.0 23.0 6.0 0.5 2DBGK 42.0 0.4523809523809524 0.5476190476190477 0.868408036967547 0.698373781566726 0.7833909092671365 0.1700342554008209 1 1 1 1 K19115 0.1142857142857142 0.1025641025641025 csh2; CRISPR-associated protein Csh2 181.0 53.0 21.0 2.0 0.623529411764706 L 43.0 42.0 1.0 1.0 COG3649 CRISPR-Cas_system_type_I_effector_complex_subunit_Cas7,__RAMP_superfamily Cas7 85.0 0.5058823529411764 0.4941176470588235 0.978751241006934 0.876073893588164 0.9274125672975492 0.1026773474187699 1 1 1 1 K19116 0.1428571428571428 0.074074074074074 cas5h; CRISPR-associated protein Cas5h 76.0 45.0 11.0 3.0 0.523255813953488 L 58.0 29.0 4.0 0.908045977011494 COG1688 CRISPR/Cas_system-associated_protein_Cas5,_RAMP_superfamily Cas5 87.0 0.6666666666666666 0.3333333333333333 0.417945906662199 0.378748845201494 0.3983473759318465 0.039197061460705 0 0 0 0 K19117 0.0142857142857142 0.1082621082621082 csd1, cas8c; CRISPR-associated protein Csd1 312.0 32.0 18.0 2.0 0.695652173913043 S 5.0 41.0 3.0 0.695652173913044 28HN3 46.0 0.108695652173913 0.8913043478260869 0.0435878394972315 0.105295200693839 0.0744415200955352 0.0617073611966075 0 0 0 0 K19118 0.02 0.1168091168091168 csd2, cas7; CRISPR-associated protein Csd2 216.0 50.0 0.0 1.0 1.0 L 7.0 43.0 1.0 1.0 COG3649 CRISPR-Cas_system_type_I_effector_complex_subunit_Cas7,__RAMP_superfamily Cas7 50.0 0.14 0.86 0.196945145353357 0.435381273359244 0.3161632093563005 0.2384361280058869 0 0 0 0 K19119 0.0257142857142857 0.1025641025641025 cas5d; CRISPR-associated protein Cas5d 143.0 39.0 31.0 2.0 0.829787234042553 S 9.0 38.0 3.0 0.808510638297872 2DBAF 47.0 0.1914893617021276 0.8085106382978723 0.0355755096966362 0.0915438872406443 0.0635596984686402 0.0559683775440081 0 0 0 0 K19120 0.0685714285714285 0.0256410256410256 csc1; CRISPR-associated protein Csc1 92.0 13.0 0.0 1.0 1.0 S 24.0 10.0 3.0 0.457142857142857 arCOG05134 34.0 0.7058823529411765 0.2941176470588235 0.0613907401397808 0.078090731783225 0.0697407359615029 0.0166999916434441 0 0 0 0 K19121 0.0657142857142857 0.0256410256410256 csc2; CRISPR-associated protein Csc2 194.0 18.0 4.0 3.0 0.529411764705882 K 23.0 11.0 1.0 1.0 arCOG03482 34.0 0.6764705882352942 0.3235294117647059 0.0342951008990229 0.10774869835722 0.0710218996281214 0.0734535974581971 0 0 0 0 K19122 0.04 0.0284900284900284 csc3; CRISPR-associated protein Csc3 492.0 8.0 0.0 1.0 1.0 S 14.0 12.0 3.0 0.538461538461538 arCOG06925 26.0 0.5384615384615384 0.4615384615384615 0.0194764860525123 0.136677793457964 0.0780771397552381 0.1172013074054516 0 0 0 0 K19123 0.0285714285714285 0.1111111111111111 casA, cse1; CRISPR system Cascade subunit CasA 77.0 34.0 4.0 3.0 0.515151515151515 L 11.0 54.0 6.0 0.5 COG1203 CRISPR-Cas_type_I_system-associated_endonuclease/helicase_Cas3 Cas3 65.0 0.1692307692307692 0.8307692307692308 0.235406321570259 0.338031626618516 0.2867189740943875 0.1026253050482569 0 0 0 0 K19124 0.0257142857142857 0.0997150997150997 casC, cse4; CRISPR system Cascade subunit CasC 241.0 40.0 33.0 2.0 0.851063829787234 L 9.0 38.0 2.0 0.851063829787234 COG1857 CRISPR-Cas_system_type_I_effector_complex_subunit_Cas7,__RAMP_superfamily Cas7 47.0 0.1914893617021276 0.8085106382978723 0.0879650756341561 0.245677473577263 0.1668212746057095 0.1577123979431068 0 0 0 0 K19125 0.0257142857142857 0.1054131054131054 casD, cse5; CRISPR system Cascade subunit CasD 133.0 38.0 29.0 4.0 0.775510204081633 S 9.0 40.0 5.0 0.63265306122449 2DBXF 49.0 0.1836734693877551 0.8163265306122449 0.037125428404259 0.0600635070831863 0.0485944677437226 0.0229380786789272 0 0 0 0 K19126 0.0257142857142857 0.1082621082621082 casE, cse3; CRISPR system Cascade subunit CasE 116.0 49.0 48.0 2.0 0.98 S 9.0 41.0 7.0 0.34 2DKU6 50.0 0.18 0.82 0.0257043061492689 0.0258166109009529 0.0257604585251109 0.000112304751684 0 0 0 0 K19127 0.0 0.0341880341880341 csy1; CRISPR-associated protein Csy1 300.0 10.0 8.0 2.0 0.833333333333333 S 0.0 12.0 2.0 0.833333333333333 2DBF1 12.0 0.0 1.0 0.0514391898630132 0.164443221887191 0.107941205875102 0.1130040320241777 0 0 0 0 K19128 0.0 0.0284900284900284 csy2; CRISPR-associated protein Csy2 261.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 2DBIX 11.0 0.0 1.0 0.0417635543015426 0.131733888987824 0.0867487216446833 0.0899703346862814 0 0 0 0 K19129 0.0 0.0284900284900284 csy3; CRISPR-associated protein Csy3 331.0 10.0 0.0 1.0 1.0 S 0.0 10.0 1.0 1.0 2DB80 10.0 0.0 1.0 0.0504293624032974 0.159314332017459 0.1048718472103782 0.1088849696141616 0 0 0 0 K19130 0.0 0.0313390313390313 csy4, cas6f; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-] 173.0 10.0 9.0 2.0 0.909090909090909 S 0.0 11.0 1.0 1.0 2CJUF 11.0 0.0 1.0 0.0497204051063403 0.170862735101893 0.1102915701041166 0.1211423299955527 0 0 0 0 K19131 0.0028571428571428 0.0256410256410256 csb1; CRISPR-associated protein Csb1 259.0 12.0 0.0 1.0 1.0 S 1.0 11.0 2.0 0.666666666666667 28IJY 12.0 0.0833333333333333 0.9166666666666666 0.034058475712653 0.0620162401227072 0.0480373579176801 0.0279577644100542 0 0 0 0 K19132 0.0028571428571428 0.0227920227920227 csb2; CRISPR-associated protein Csb2 266.0 11.0 0.0 1.0 1.0 S 1.0 10.0 3.0 0.454545454545455 2DBSW 11.0 0.0909090909090909 0.9090909090909092 0.029624849465131 0.0692196349924684 0.0494222422287997 0.0395947855273374 0 0 0 0 K19134 0.0114285714285714 0.0769230769230769 csx10; CRISPR-associated protein Csx10 65.0 36.0 32.0 2.0 0.9 L 5.0 34.0 5.0 0.725 COG1337 CRISPR-Cas_system_type_III_CSM-effector_complex_subunit_Csm3,_RAMP_superfamily_Cas7_group Csm3 39.0 0.1282051282051282 0.8717948717948718 0.0707289369527748 0.659805069115592 0.3652670030341834 0.5890761321628172 0 0 0 0 K19135 0.0428571428571428 0.0341880341880341 csx14; CRISPR-associated protein Csx14 66.0 10.0 2.0 4.0 0.4 V 19.0 15.0 5.0 0.529411764705882 arCOG03847 34.0 0.5588235294117647 0.4411764705882353 0.266412390219225 0.926841807176942 0.5966270986980835 0.660429416957717 0 0 0 0 K19136 0.0028571428571428 0.017094017094017 csx17; CRISPR-associated protein Csx17 519.0 2.0 0.0 1.0 1.0 S 1.0 7.0 1.0 1.0 28JGZ 8.0 0.125 0.875 0.0295327663544401 0.0664562034238876 0.0479944848891638 0.0369234370694474 0 0 0 0 K19137 0.0 0.0113960113960113 csn2; CRISPR-associated protein Csn2 198.0 4.0 0.0 1.0 1.0 S 0.0 4.0 3.0 0.5 298VG 4.0 0.0 1.0 0.0493453235942177 0.135932747465828 0.0926390355300228 0.0865874238716103 0 0 0 0 K19138 0.0257142857142857 0.0769230769230769 csm2; CRISPR-associated protein Csm2 69.0 35.0 32.0 3.0 0.897435897435897 L 10.0 29.0 2.0 0.974358974358975 COG1421 CRISPR-Cas_system_type_III_CSM-effector_complex_small_subunit_Csm2 Csm2 39.0 0.2564102564102564 0.7435897435897436 0.869684242821917 0.878934275609701 0.874309259215809 0.009250032787784 1 1 1 1 K19139 0.0428571428571428 0.0769230769230769 csm4; CRISPR-associated protein Csm4 130.0 34.0 25.0 2.0 0.790697674418605 L 17.0 29.0 2.0 0.934782608695652 COG1567 CRISPR-Cas_system_type_III_CSM-effector_complex_subunit_Csm4,_RAMP_superfamily_Cas5_group Csm4 46.0 0.3695652173913043 0.6304347826086957 0.937669549970775 0.936235065111997 0.936952307541386 0.001434484858778 1 1 1 1 K19140 0.0428571428571428 0.0826210826210826 csm5; CRISPR-associated protein Csm5 76.0 33.0 21.0 3.0 0.717391304347826 L 16.0 33.0 3.0 0.918367346938776 COG1332 CRISPR-Cas_system_type_III_CSM-effector_complex_subunit_Csm5,_RAMP_superfamily_Cas7_group Csm5 49.0 0.3265306122448979 0.673469387755102 0.799827590524774 0.882617514287706 0.84122255240624 0.0827899237629319 1 1 1 1 K19141 0.0371428571428571 0.074074074074074 cmr5; CRISPR-associated protein Cmr5 61.0 40.0 36.0 2.0 0.909090909090909 L 15.0 29.0 2.0 0.977272727272727 COG3337 CRISPR-Cas_system_type_III_CMR-effector_complex_small_subunit_Cmr5 Cmr5 44.0 0.3409090909090909 0.6590909090909091 0.170788758063408 0.977581965498778 0.574185361781093 0.80679320743537 0 0 0 0 K19142 0.0742857142857142 0.1196581196581196 cmr6; CRISPR-associated protein Cmr6 73.0 59.0 38.0 4.0 0.694117647058823 L 31.0 54.0 3.0 0.870588235294118 COG1604 CRISPR/Cas_system_CMR_subunit_Cmr6,_Cas7_group,_RAMP_superfamily Cmr6 85.0 0.3647058823529411 0.6352941176470588 0.22042444239648 0.986604346372721 0.6035143943846005 0.7661799039762409 0 0 0 0 K19143 0.1057142857142857 0.017094017094017 csx1; CRISPR-associated protein Csx1 103.0 31.0 3.0 2.0 0.525423728813559 L 52.0 7.0 2.0 0.898305084745763 COG1517 CRISPR/Cas_system-associated_protein_Csx1,_contains_CARF_domain Csx1 59.0 0.8813559322033898 0.1186440677966101 0.877487244844856 0.633918450383844 0.7557028476143499 0.2435687944610119 1 1 1 1 K19144 0.0171428571428571 0.0427350427350427 csx3; CRISPR-associated protein Csx3 61.0 15.0 9.0 3.0 0.6 S 6.0 19.0 4.0 0.44 COG1100 GTPase_SAR1_family_domain Gem1 25.0 0.24 0.76 0.947370921551361 0.830857745733545 0.889114333642453 0.116513175817816 1 1 1 1 K19145 0.0028571428571428 0.0142450142450142 csx16; CRISPR-associated protein Csx16 32.0 3.0 1.0 3.0 0.5 L 1.0 5.0 2.0 0.666666666666667 COG1517 CRISPR/Cas_system-associated_protein_Csx1,_contains_CARF_domain Csx1 6.0 0.1666666666666666 0.8333333333333334 0.155062100646299 0.290811143497395 0.222936622071847 0.135749042851096 0 0 0 0 K19146 0.0085714285714285 0.0 csaX; CRISPR-associated protein CsaX 311.0 3.0 0.0 1.0 1.0 arCOG07299 3.0 1.0 0.0 0 0 0 0 K19147 0.0542857142857142 0.0968660968660968 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 105.0 56.0 55.0 2.0 0.982456140350877 V 20.0 37.0 1.0 1.0 COG4268 5-methylcytosine-specific_restriction_endonuclease_McrBC,_regulatory_subunit_McrC McrC 57.0 0.3508771929824561 0.6491228070175439 0.236140127632514 0.674308407998578 0.455224267815546 0.438168280366064 0 0 0 0 K19155 0.0 0.037037037037037 yhaV; toxin YhaV [EC:3.1.-.-] 140.0 12.0 11.0 3.0 0.857142857142857 S 0.0 14.0 1.0 1.0 28N0M 14.0 0.0 1.0 0.0171052365713205 0.0381965071535231 0.0276508718624218 0.0210912705822026 0 0 0 0 K19156 0.0 0.0512820512820512 prlF, sohA; antitoxin PrlF 51.0 14.0 13.0 2.0 0.933333333333333 K 0.0 24.0 5.0 0.583333333333333 COG2002 Bifunctional_DNA-binding_transcriptional_regulator_of_stationary/sporulation/toxin_gene_expression_and_antitoxin_component_of_the_YhaV-PrlF_toxin-antitoxin_module AbrB 24.0 0.0 1.0 0.0104527834066594 0.0231615303054379 0.0168071568560486 0.0127087468987785 0 0 0 0 K19157 0.0 0.094017094017094 yafQ; mRNA interferase YafQ [EC:3.1.-.-] 81.0 42.0 0.0 1.0 1.0 S 0.0 42.0 1.0 1.0 COG3041 mRNA-degrading_endonuclease_YafQ_(mRNA_interferase),_toxin_component_of_the_YafQ-DinJ_toxin-antitoxin_module YafQ 42.0 0.0 1.0 0.0398555751027493 0.117930761018842 0.0788931680607956 0.0780751859160927 0 0 0 0 K19158 0.0371428571428571 0.1595441595441595 yoeB; toxin YoeB [EC:3.1.-.-] 67.0 58.0 48.0 4.0 0.707317073170732 S 14.0 68.0 3.0 0.817073170731707 COG4115 Toxin_component_of_the_Txe-Axe_toxin-antitoxin_module,_Txe/YoeB_family 82.0 0.1707317073170731 0.8292682926829268 0.0956489187951125 0.177965547332012 0.1368072330635622 0.0823166285368995 0 0 0 0 K19159 0.0 0.1965811965811965 yefM; antitoxin YefM 65.0 86.0 83.0 2.0 0.966292134831461 D 0.0 93.0 3.0 0.967391304347826 COG2161 Antitoxin_component_YafN_of_the_YafNO_toxin-antitoxin_module,_PHD/YefM_family StbD 93.0 0.0 1.0 0.053327089553031 0.304365198167578 0.1788461438603045 0.251038108614547 0 0 0 0 K19160 0.0 0.0028490028490028 yafO; mRNA interferase YafO [EC:3.1.-.-] 132.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28S4M 1.0 0.0 1.0 0 0 0 0 K19161 0.0 0.0028490028490028 yafN; antitoxin YafN 97.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG2161 Antitoxin_component_YafN_of_the_YafNO_toxin-antitoxin_module,_PHD/YefM_family StbD 1.0 0.0 1.0 0 0 0 0 K19162 0.0 0.0085470085470085 tomB; hha toxicity modulator TomB 113.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 28PF7 3.0 0.0 1.0 0 0 0 0 K19163 0.0 0.037037037037037 ccdB; toxin CcdB 87.0 13.0 0.0 1.0 1.0 S 0.0 13.0 2.0 0.923076923076923 2DNNV 13.0 0.0 1.0 0.0157030174532097 0.0322674298822331 0.0239852236677214 0.0165644124290234 0 0 0 0 K19164 0.0 0.037037037037037 ccdA; antitoxin CcdA 75.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG5302 Post-segregation_antitoxin_(ccd_killing_mechanism_protein)_encoded_by_the_F_plasmid 15.0 0.0 1.0 0.0140620353981444 0.0179116987812055 0.0159868670896749 0.0038496633830611 0 0 0 0 K19165 0.0 0.0313390313390313 phd; antitoxin Phd 66.0 9.0 6.0 2.0 0.75 S 0.0 12.0 4.0 0.583333333333333 2E4DC 12.0 0.0 1.0 0.0460604112419571 0.0905492477412813 0.0683048294916192 0.0444888364993242 0 0 0 0 K19166 0.0 0.0911680911680911 higB; mRNA interferase HigB [EC:3.1.-.-] 68.0 41.0 35.0 3.0 0.854166666666667 S 0.0 48.0 1.0 1.0 COG4680 mRNA-degrading_endonuclease_(mRNA_interferase)_HigB,_toxic_component_of_the_HigAB_toxin-antitoxin_module HigB 48.0 0.0 1.0 0.0122704808471825 0.0395278967297301 0.0258991887884563 0.0272574158825476 0 0 0 0 K19167 0.0 0.0085470085470085 abiQ; protein AbiQ 88.0 3.0 0.0 1.0 1.0 S 0.0 3.0 3.0 0.333333333333333 2EAJ6 3.0 0.0 1.0 0 0 0 0 K19168 0.0 0.0484330484330484 cptA; toxin CptA 31.0 6.0 1.0 6.0 0.31578947368421 O 0.0 19.0 9.0 0.25 COG0694 Fe-S_cluster_biogenesis_protein_NfuA,_4Fe-4S-binding_domain NifU 19.0 0.0 1.0 0.0414388203525815 0.100038874918947 0.0707388476357642 0.0586000545663655 0 0 0 0 K19169 0.0057142857142857 0.0512820512820512 dndB; DNA sulfur modification protein DndB 288.0 19.0 17.0 2.0 0.904761904761905 S 2.0 19.0 5.0 0.619047619047619 arCOG09463 21.0 0.0952380952380952 0.9047619047619048 0.0985302272056936 0.156363939340538 0.1274470832731158 0.0578337121348443 0 0 0 0 K19170 0.0228571428571428 0.0712250712250712 dndC; DNA sulfur modification protein DndC 354.0 26.0 20.0 3.0 0.787878787878788 EH 8.0 25.0 1.0 1.0 COG0175 3'-phosphoadenosine_5'-phosphosulfate_sulfotransferase_(PAPS_reductase)/FAD_synthetase_or_related_enzyme CysD 33.0 0.2424242424242424 0.7575757575757576 0.628108391111935 0.55019479096394 0.5891515910379375 0.0779136001479949 0 1 0 1 K19171 0.0742857142857142 0.1054131054131054 dndD; DNA sulfur modification protein DndD 95.0 58.0 38.0 5.0 0.69047619047619 L 31.0 53.0 7.0 0.416666666666667 COG0419 DNA_repair_exonuclease_SbcCD_ATPase_subunit SbcC 84.0 0.369047619047619 0.6309523809523809 0.196917962161184 0.578665217626155 0.3877915898936694 0.3817472554649709 0 0 0 0 K19172 0.06 0.0826210826210826 dndE; DNA sulfur modification protein DndE 51.0 38.0 31.0 5.0 0.730769230769231 S 21.0 31.0 8.0 0.403846153846154 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 52.0 0.4038461538461538 0.5961538461538461 0.093111280978867 0.425078833271149 0.259095057125008 0.331967552292282 0 0 0 0 K19173 0.0028571428571428 0.017094017094017 dptF; DNA phosphorothioation-dependent restriction protein DptF 487.0 4.0 1.0 2.0 0.571428571428571 V 1.0 6.0 1.0 1.0 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 7.0 0.1428571428571428 0.8571428571428571 0.0999756874970962 0.240140035373139 0.1700578614351175 0.1401643478760428 0 0 0 0 K19174 0.0 0.017094017094017 dptG; DNA phosphorothioation-dependent restriction protein DptG 416.0 0.0 6.0 1.0 1.0 28IJJ 6.0 0.0 1.0 0 0 0 0 K19175 0.0114285714285714 0.0256410256410256 dptH; DNA phosphorothioation-dependent restriction protein DptH 66.0 9.0 4.0 4.0 0.529411764705882 S 4.0 12.0 1.0 1.0 COG0433 Archaeal_DNA_helicase_HerA_or_a_related_bacterial_ATPase,_contains_HAS-barrel_and_ATPase_domains HerA 16.0 0.25 0.75 0.0362504061970553 0.122709678205533 0.0794800422012941 0.0864592720084777 0 0 0 0 K19176 0.0 0.0028490028490028 FAAH2; fatty acid amide hydrolase 2 [EC:3.5.1.99] 480.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 1.0 0.0 1.0 0 0 0 0 K19180 0.0171428571428571 0.0512820512820512 tll; dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) [EC:1.1.1.339] path:map00523,path:map00541,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 179.0 22.0 19.0 2.0 0.88 GM 6.0 19.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 25.0 0.24 0.76 0.256998970114654 0.555157554944954 0.406078262529804 0.2981585848303 0 0 0 0 K19181 0.02 0.0199430199430199 afr; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) [EC:1.1.1.292] 257.0 14.0 13.0 2.0 0.933333333333333 S 7.0 8.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 15.0 0.4666666666666667 0.5333333333333333 0.0683563181761081 0.22163207045614 0.144994194316124 0.1532757522800319 0 0 0 0 K19186 0.0 0.0113960113960113 kdhB; 6-hydroxypseudooxynicotine dehydrogenase subunit beta [EC:1.5.99.14] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 149.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 5.0 0.0 1.0 0.429465504827586 0.0923423317980818 0.2609039183128339 0.3371231730295042 0 0 0 0 K19188 0.0057142857142857 0.0028490028490028 dhponh; 2,6-dihydroxypseudooxynicotine hydrolase [EC:3.7.1.19] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 253.0 3.0 0.0 1.0 1.0 S 2.0 1.0 1.0 1.0 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K19189 0.0 0.0142450142450142 dhpH; 2,6-dihydroxypyridine 3-monooxygenase [EC:1.14.13.10] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 170.0 5.0 0.0 1.0 1.0 CH 0.0 5.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 5.0 0.0 1.0 0.13985242074942 0.239617559476942 0.189734990113181 0.0997651387275219 0 0 0 0 K19190 0.0114285714285714 0.1054131054131054 nboR; nicotine blue oxidoreductase [EC:1.1.1.328] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 131.0 27.0 13.0 2.0 0.658536585365854 S 4.0 37.0 2.0 0.975609756097561 COG2068 CTP:molybdopterin_cytidylyltransferase_MocA MocA 41.0 0.0975609756097561 0.902439024390244 0.781718928120219 0.824025391614386 0.8028721598673025 0.042306463494167 1 1 1 1 K19191 0.0 0.0455840455840455 mabO; 4-methylaminobutanoate oxidase (formaldehyde-forming) [EC:1.5.3.19] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 765.0 18.0 0.0 1.0 1.0 E 0.0 18.0 2.0 0.833333333333333 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 18.0 0.0 1.0 0.055177360566256 0.174829056801777 0.1150032086840164 0.119651696235521 0 0 0 0 K19200 0.04 0.0512820512820512 IAL; isopenicillin-N N-acyltransferase like protein path:map00311,path:map01100,path:map01110 Penicillin and cephalosporin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 150.0 30.0 29.0 2.0 0.967741935483871 S 17.0 22.0 3.0 0.769230769230769 COG4927 Predicted_choloylglycine_hydrolase 39.0 0.4358974358974359 0.5641025641025641 0.0938757317474995 0.100023602433427 0.0969496670904632 0.0061478706859275 0 0 0 0 K19204 0.0 0.0085470085470085 pimS2; pimaricinolide synthase PimS2 path:map01052 Type I polyketide structures 1101.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 2.0 0.666666666666667 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 3.0 0.0 1.0 0 0 0 0 K19207 0.0 0.0085470085470085 fscD; candicidin polyketide synthase FscD path:map01052 Type I polyketide structures 1101.0 2.0 1.0 2.0 0.666666666666667 Q 0.0 3.0 2.0 0.666666666666667 COG3321 Acyl_transferase_domain_in_polyketide_synthase_(PKS)_enzymes PksD 3.0 0.0 1.0 0 0 0 0 K19209 0.0 0.0028490028490028 blaOXA-42; beta-lactamase class D OXA-42 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 69.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K19210 0.0028571428571428 0.0028490028490028 blaOXA-61; beta-lactamase class D OXA-61 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 268.0 2.0 0.0 1.0 1.0 V 1.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.5 0.5 0 0 0 0 K19211 0.0 0.0028490028490028 blaOXA-62; beta-lactamase class D OXA-62 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 266.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 1.0 0.0 1.0 0 0 0 0 K19213 0.0 0.0028490028490028 blaOXA-12; beta-lactamase class D OXA-12 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 69.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K19215 0.0 0.0085470085470085 blaACT_MIR; beta-lactamase class C ACT/MIR [EC:3.5.2.6] path:map01501 beta-Lactam resistance 375.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 3.0 0.0 1.0 0 0 0 0 K19217 0.0 0.0113960113960113 blaCARB-17; beta-lactamase class A CARB-17 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 41.0 4.0 0.0 1.0 1.0 V 0.0 4.0 1.0 1.0 COG2367 Beta-lactamase_class_A PenP 4.0 0.0 1.0 0.0949241652872091 0.281355284169882 0.1881397247285455 0.1864311188826728 0 0 0 0 K19219 0.0 0.0028490028490028 JMJD7; peptidyl-lysine (3S)-dioxygenase / protease [EC:1.14.11.63 3.4.-.-] 249.0 2.0 0.0 2.0 0.5 P 0.0 4.0 1.0 1.0 COG2850 Ribosomal_protein_L16_Arg81_hydroxylase,_contains_JmjC_domain RoxA 4.0 0.0 1.0 6.69311694238899e-07 1.64008583558508e-17 3.3465584712765e-07 6.693116942224981e-07 0 0 0 0 K19220 0.0 0.0113960113960113 cwlS; peptidoglycan DL-endopeptidase CwlS [EC:3.4.-.-] 78.0 2.0 1.0 3.0 0.5 M 0.0 4.0 3.0 0.5 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 4.0 0.0 1.0 0.0129369650675678 0.0056319566373315 0.0092844608524496 0.0073050084302363 0 0 0 0 K19221 0.4371428571428571 0.4729344729344729 cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 95.0 350.0 346.0 3.0 0.985915492957746 H 158.0 197.0 3.0 0.983098591549296 COG2109 ATP:corrinoid_adenosyltransferase BtuR 355.0 0.4450704225352113 0.5549295774647888 0.164249272292035 0.952398585372459 0.558323928832247 0.788149313080424 0 0 0 0 K19222 0.0 0.1111111111111111 menI, DHNAT; 1,4-dihydroxy-2-naphthoyl-CoA hydrolase [EC:3.1.2.28] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 118.0 39.0 0.0 1.0 1.0 Q 0.0 39.0 2.0 0.923076923076923 COG2050 Acyl-CoA_thioesterase_PaaI,_contains_HGG_motif PaaI 39.0 0.0 1.0 0.0012784380451661 0.0031151335955421 0.0021967858203541 0.001836695550376 0 0 0 0 K19223 0.0028571428571428 0.0427350427350427 lytF, cwlE; peptidoglycan DL-endopeptidase LytF [EC:3.4.-.-] 36.0 13.0 9.0 3.0 0.68421052631579 M 1.0 18.0 3.0 0.68421052631579 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 19.0 0.0526315789473684 0.9473684210526316 0.029101553824146 0.164064022038701 0.0965827879314235 0.134962468214555 0 0 0 0 K19224 0.0028571428571428 0.0655270655270655 lytE, cwlF; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-] 67.0 29.0 28.0 2.0 0.966666666666667 M 1.0 29.0 2.0 0.933333333333333 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 30.0 0.0333333333333333 0.9666666666666668 0.0101321761824684 0.150799892504088 0.0804660343432782 0.1406677163216196 0 0 0 0 K19225 0.1 0.2478632478632478 gluP; rhomboid protease GluP [EC:3.4.21.105] 76.0 93.0 76.0 6.0 0.694029850746269 S 37.0 97.0 4.0 0.902985074626866 COG0705 Membrane-associated_serine_protease,_rhomboid_family GlpG 134.0 0.2761194029850746 0.7238805970149254 0.242474973350007 0.925922468572349 0.584198720961178 0.6834474952223419 0 0 0 0 K19226 0.0 0.0227920227920227 sapA; cationic peptide transport system substrate-binding protein path:map01503,path:map02010 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters 521.0 8.0 0.0 1.0 1.0 E 0.0 8.0 2.0 0.75 COG4166 ABC-type_oligopeptide_transport_system,_periplasmic_component OppA 8.0 0.0 1.0 0.0077579262255484 0.0179284328754102 0.0128431795504793 0.0101705066498617 0 0 0 0 K19227 0.0 0.0199430199430199 sapB; cationic peptide transport system permease protein path:map01503,path:map02010 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters 313.0 7.0 5.0 3.0 0.7 P 0.0 10.0 2.0 0.5 COG4168 ABC-type_antimicrobial_peptide_export_system,_permease_component_SapB SapB 10.0 0.0 1.0 0.004108060967678 0.0087158079006188 0.0064119344341484 0.0046077469329408 0 0 0 0 K19228 0.0 0.0199430199430199 sapC; cationic peptide transport system permease protein path:map01503,path:map02010 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters 296.0 7.0 0.0 1.0 1.0 V 0.0 7.0 1.0 1.0 COG4171 ABC-type_antimicrobial_peptide_export_system,_permease_component_SapC SapC 7.0 0.0 1.0 1.61125089187874e-21 8.96031919552132e-17 4.4802401603052536e-17 8.960158070432131e-17 0 0 0 0 K19229 0.0 0.0199430199430199 sapD; cationic peptide transport system ATP-binding protein path:map01503,path:map02010 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters 22.0 14.0 0.0 1.0 1.0 P 0.0 14.0 1.0 1.0 COG1123 ABC-type_glutathione_transport_system_ATPase_component,_contains_duplicated_ATPase_domain GsiA 14.0 0.0 1.0 0.0011812641901521 0.0024972004928099 0.0018392323414809 0.0013159363026577 0 0 0 0 K19230 0.0 0.0199430199430199 sapF; cationic peptide transport system ATP-binding protein path:map01503,path:map02010 Cationic antimicrobial peptide (CAMP) resistance,ABC transporters 252.0 16.0 15.0 2.0 0.941176470588235 P 0.0 17.0 2.0 0.764705882352941 COG1123 ABC-type_glutathione_transport_system_ATPase_component,_contains_duplicated_ATPase_domain GsiA 17.0 0.0 1.0 0.0014740548385851 0.0029561369473298 0.0022150958929574 0.0014820821087447 0 0 0 0 K19231 0.0028571428571428 0.037037037037037 bmaC; fibronectin-binding autotransporter adhesin 166.0 6.0 1.0 7.0 0.352941176470588 U 1.0 16.0 6.0 0.470588235294118 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 17.0 0.0588235294117647 0.9411764705882352 0.0730674253702338 0.113537862211434 0.0933026437908338 0.0404704368412002 0 0 0 0 K19232 0.0 0.0028490028490028 btaE; hyaluronate-binding autotransporter adhesin 466.0 1.0 0.0 1.0 1.0 UW 0.0 1.0 1.0 1.0 COG5295 Autotransporter_adhesin Hia 1.0 0.0 1.0 0 0 0 0 K19233 0.0 0.0056980056980056 btaF; ECM component-binding autotransporter adhesin 1339.0 2.0 0.0 1.0 1.0 UW 0.0 2.0 1.0 1.0 COG3210 Large_exoprotein_involved_in_heme_utilization_or_adhesion FhaB 2.0 0.0 1.0 0 0 0 0 K19234 0.0 0.0142450142450142 ynhG; L,D-transpeptidase YnhG 238.0 4.0 2.0 3.0 0.571428571428571 M 0.0 7.0 1.0 1.0 COG1376 Lipoprotein-anchoring_transpeptidase_ErfK/SrfK ErfK 7.0 0.0 1.0 0.0161988343075642 0.0318753973104496 0.0240371158090069 0.0156765630028854 0 0 0 0 K19235 0.0 0.0113960113960113 ybiS; L,D-transpeptidase YbiS 293.0 4.0 2.0 2.0 0.666666666666667 M 0.0 6.0 1.0 1.0 COG1376 Lipoprotein-anchoring_transpeptidase_ErfK/SrfK ErfK 6.0 0.0 1.0 4.23145603926339e-10 6.3236868688399e-06 3.162055007221913e-06 6.323263723235974e-06 0 0 0 0 K19236 0.0 0.0142450142450142 ycfS; L,D-transpeptidase YcfS path:map01503 Cationic antimicrobial peptide (CAMP) resistance 292.0 5.0 3.0 2.0 0.714285714285714 M 0.0 7.0 1.0 1.0 COG1376 Lipoprotein-anchoring_transpeptidase_ErfK/SrfK ErfK 7.0 0.0 1.0 0.0115979068516947 0.020834247091919 0.0162160769718068 0.0092363402402243 0 0 0 0 K19238 0.0 0.0028490028490028 pmrD; signal transduction protein PmrD path:map01503 Cationic antimicrobial peptide (CAMP) resistance 88.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2EDNI 1.0 0.0 1.0 0 0 0 0 K19242 0.0 0.0113960113960113 citR; LysR family transcriptional regulator, repressor for citA 280.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 4.0 0.0 1.0 0.0065236620963024 0.0321283552806191 0.0193260086884607 0.0256046931843167 0 0 0 0 K19243 0.1171428571428571 0.0085470085470085 azf; NAD+ dependent glucose-6-phosphate dehydrogenase [EC:1.1.1.388] path:map00030,path:map01100,path:map01110,path:map01120,path:map01200 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 238.0 52.0 42.0 2.0 0.838709677419355 M 55.0 7.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 62.0 0.8870967741935484 0.1129032258064516 0.0046769940812747 0.0042067510969995 0.0044418725891371 0.0004702429842751 0 0 0 0 K19244 0.4028571428571428 0.0712250712250712 ala; alanine dehydrogenase [EC:1.4.1.1] path:map00250,path:map00430,path:map01100 Alanine, aspartate and glutamate metabolism,Taurine and hypotaurine metabolism,Metabolic pathways 200.0 268.0 267.0 2.0 0.996282527881041 E 238.0 31.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 269.0 0.8847583643122676 0.1152416356877323 0.358960724631957 0.822039558082353 0.590500141357155 0.4630788334503959 0 0 0 0 K19245 0.0 0.0028490028490028 JLP1; sulfonate dioxygenase [EC:1.14.11.-] 195.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 1.0 0.0 1.0 0 0 0 0 K19246 0.0 0.017094017094017 loxA; arachidonate 15-lipoxygenase [EC:1.13.11.33] path:map00590,path:map01100 Arachidonic acid metabolism,Metabolic pathways 428.0 2.0 1.0 4.0 0.4 P 0.0 6.0 3.0 0.5 2DBJG 6.0 0.0 1.0 0.0390529071401675 0.0514717061918681 0.0452623066660178 0.0124187990517005 0 0 0 0 K19265 0.0028571428571428 0.2165242165242165 gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] 296.0 85.0 0.0 1.0 1.0 C 1.0 84.0 1.0 1.0 COG0667 Pyridoxal_reductase_PdxI_or_related_oxidoreductase,_aldo/keto_reductase_family PdxI 85.0 0.0117647058823529 0.9882352941176472 0.196287453598598 0.362559518316764 0.2794234859576809 0.1662720647181659 0 0 0 0 K19266 0.0314285714285714 0.0 E1.2.1.22; lactaldehyde dehydrogenase [EC:1.2.1.22] path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 459.0 11.0 0.0 1.0 1.0 C 11.0 0.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 11.0 1.0 0.0 0.0018164922386971 0.0026123191351702 0.0022144056869336 0.000795826896473 0 0 0 0 K19267 0.0057142857142857 0.1652421652421652 qorB; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 213.0 80.0 0.0 1.0 1.0 GM 2.0 78.0 1.0 1.0 COG0702 Uncharacterized_conserved_protein_YbjT,_contains_NAD(P)-binding_and_DUF2867_domains YbjT 80.0 0.025 0.975 0.0116153932761835 0.0988955973705543 0.0552554953233688 0.0872802040943708 0 0 0 0 K19268 0.0428571428571428 0.0484330484330484 glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1] path:map00630,path:map00660,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 469.0 32.0 31.0 3.0 0.941176470588235 E 16.0 18.0 2.0 0.941176470588235 COG4865 Glutamate_mutase_epsilon_subunit GlmE 34.0 0.4705882352941176 0.5294117647058824 0.635307458821084 0.687238085363351 0.6612727720922175 0.0519306265422669 0 1 0 1 K19269 0.0057142857142857 0.0 PGP, PGLP; phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48] path:map00630,path:map01100,path:map01110,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Carbon metabolism 116.0 2.0 0.0 1.0 1.0 P 2.0 0.0 1.0 1.0 COG0647 Ribonucleotide_monophosphatase_NagD,_HAD_superfamily NagD 2.0 1.0 0.0 0 0 0 0 K19270 0.0114285714285714 0.1253561253561253 hxpA; mannitol-1-/sugar-/sorbitol-6-phosphatase [EC:3.1.3.22 3.1.3.23 3.1.3.50] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 95.0 54.0 50.0 2.0 0.931034482758621 S 4.0 54.0 1.0 1.0 COG0637 Beta-phosphoglucomutase,_HAD_superfamily YcjU 58.0 0.0689655172413793 0.9310344827586208 0.0269236145500669 0.873919810093513 0.4504217123217899 0.8469961955434462 0 0 0 0 K19271 0.0142857142857142 0.0655270655270655 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28] 127.0 39.0 0.0 1.0 1.0 V 8.0 31.0 2.0 0.948717948717949 COG4845 Chloramphenicol_O-acetyltransferase CatA 39.0 0.2051282051282051 0.7948717948717948 0.0074521711088029 0.0424095775123274 0.0249308743105651 0.0349574064035245 0 0 0 0 K19272 0.0028571428571428 0.0085470085470085 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95] 72.0 4.0 0.0 1.0 1.0 J 1.0 3.0 1.0 1.0 COG3231 Aminoglycoside_phosphotransferase Aph 4.0 0.25 0.75 0.386947005168626 0.449073089618142 0.418010047393384 0.062126084449516 0 0 0 0 K19273 0.0 0.0113960113960113 sat4; streptothricin acetyltransferase [EC:2.3.-.-] 155.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 4.0 0.0 1.0 0.0285709964874762 0.0651870858888869 0.0468790411881815 0.0366160894014107 0 0 0 0 K19278 0.0 0.0028490028490028 aac6-Ib; aminoglycoside 6'-N-acetyltransferase Ib [EC:2.3.1.82] 166.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 1.0 0.0 1.0 0 0 0 0 K19279 0.0085714285714285 0.017094017094017 ant9; aminoglycoside 9-adenylyltransferase [EC:2.7.7.-] 103.0 9.0 0.0 1.0 1.0 S 3.0 6.0 1.0 1.0 COG1708 Predicted_nucleotidyltransferase,_MJ0604_family MJ0604 9.0 0.3333333333333333 0.6666666666666666 0.0459150877384921 0.167764049478809 0.1068395686086505 0.1218489617403169 0 0 0 0 K19280 0.04 0.0 mct; succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 385.0 14.0 0.0 1.0 1.0 C 14.0 0.0 1.0 1.0 COG1804 Crotonobetainyl-CoA:carnitine_CoA-transferase_CaiB_and_related_acyl-CoA_transferases CaiB 14.0 1.0 0.0 0.0073060366850821 0.0147096874814122 0.0110078620832471 0.0074036507963301 0 0 0 0 K19281 0.0457142857142857 0.0 mcl; beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24] path:map00630,path:map00660,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,C5-Branched dibasic acid metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 344.0 16.0 0.0 1.0 1.0 G 16.0 0.0 1.0 1.0 COG2301 Citrate_lyase_beta_subunit CitE 16.0 1.0 0.0 0.0098115373324768 0.020494754261 0.0151531457967384 0.0106832169285232 0 0 0 0 K19282 0.0428571428571428 0.0 aceB; bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] path:map00630,path:map01100,path:map01120,path:map01200 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 431.0 17.0 0.0 1.0 1.0 G 17.0 0.0 1.0 1.0 COG2301 Citrate_lyase_beta_subunit CitE 17.0 1.0 0.0 0.0157762759123251 0.027996687990585 0.021886481951455 0.0122204120782598 0 0 0 0 K19285 0.0228571428571428 0.0712250712250712 nfrA1; FMN reductase (NADPH) [EC:1.5.1.38] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 177.0 35.0 0.0 1.0 1.0 C 8.0 27.0 1.0 1.0 COG0778 Nitroreductase NfnB 35.0 0.2285714285714285 0.7714285714285715 0.605870575927392 0.891795831564279 0.7488332037458355 0.285925255636887 0 1 0 1 K19286 0.0685714285714285 0.0569800569800569 nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 118.0 47.0 0.0 1.0 1.0 C 25.0 22.0 1.0 1.0 COG0778 Nitroreductase NfnB 47.0 0.5319148936170213 0.4680851063829787 0.440575777327239 0.853510650858536 0.6470432140928875 0.4129348735312969 0 0 0 0 K19290 0.0 0.0199430199430199 alg8; mannuronan synthase [EC:2.4.1.33] path:map00051,path:map00543,path:map01100 Fructose and mannose metabolism,Exopolysaccharide biosynthesis,Metabolic pathways 472.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 7.0 0.0 1.0 0.0769636238343053 0.159047767201397 0.1180056955178511 0.0820841433670916 0 0 0 0 K19291 0.0 0.017094017094017 alg44; mannuronan synthase [EC:2.4.1.33] path:map00051,path:map00543,path:map01100,path:map02025 Fructose and mannose metabolism,Exopolysaccharide biosynthesis,Metabolic pathways,Biofilm formation - Pseudomonas aeruginosa 320.0 4.0 2.0 2.0 0.666666666666667 V 0.0 6.0 2.0 0.666666666666667 COG1566 Multidrug_resistance_efflux_pump_EmrA EmrA 6.0 0.0 1.0 0.0510442396271066 0.146965058570244 0.0990046490986753 0.0959208189431373 0 0 0 0 K19292 0.0 0.0056980056980056 algK; alginate biosynthesis protein AlgK 228.0 3.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 COG0790 TPR_repeat TPR 3.0 0.0 1.0 0 0 0 0 K19293 0.0 0.0056980056980056 algX; alginate biosynthesis protein AlgX path:map00543 Exopolysaccharide biosynthesis 454.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 28IPV 2.0 0.0 1.0 0 0 0 0 K19294 0.0028571428571428 0.1396011396011396 algI; alginate O-acetyltransferase complex protein AlgI path:map00543 Exopolysaccharide biosynthesis 300.0 71.0 69.0 2.0 0.972602739726027 M 1.0 72.0 2.0 0.972602739726027 COG1696 D-alanyl-lipoteichoic_acid_acyltransferase_DltB,_MBOAT_superfamily DltB 73.0 0.0136986301369863 0.9863013698630136 0.021504242273453 0.035608235079565 0.028556238676509 0.014103992806112 0 0 0 0 K19295 0.0 0.017094017094017 algJ; alginate O-acetyltransferase complex protein AlgJ path:map00543 Exopolysaccharide biosynthesis 302.0 10.0 0.0 1.0 1.0 S 0.0 10.0 4.0 0.7 2C7PP 10.0 0.0 1.0 0.017351693152323 0.0372232587262738 0.0272874759392984 0.0198715655739508 0 0 0 0 K19296 0.0 0.0056980056980056 algF; alginate O-acetyltransferase complex protein AlgF path:map00543 Exopolysaccharide biosynthesis 199.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 2C09I 2.0 0.0 1.0 0 0 0 0 K19299 0.0057142857142857 0.0142450142450142 aph3-III; aminoglycoside 3'-phosphotransferase III [EC:2.7.1.95] 201.0 5.0 3.0 2.0 0.714285714285714 J 2.0 5.0 1.0 1.0 COG3231 Aminoglycoside_phosphotransferase Aph 7.0 0.2857142857142857 0.7142857142857143 0.395221919997584 0.539171442472099 0.4671966812348415 0.143949522474515 0 0 0 0 K19300 0.0028571428571428 0.0085470085470085 aph3-II; aminoglycoside 3'-phosphotransferase II [EC:2.7.1.95] 182.0 4.0 0.0 1.0 1.0 J 1.0 3.0 1.0 1.0 COG3231 Aminoglycoside_phosphotransferase Aph 4.0 0.25 0.75 0.394981796487359 0.45013038346021 0.4225560899737844 0.055148586972851 0 0 0 0 K19301 0.0 0.0056980056980056 aac6-II; aminoglycoside 6'-N-acetyltransferase II [EC:2.3.1.82] 169.0 2.0 0.0 1.0 1.0 J 0.0 2.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 2.0 0.0 1.0 0 0 0 0 K19302 0.4142857142857143 0.6239316239316239 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] path:map00550,path:map00552 Peptidoglycan biosynthesis,Teichoic acid biosynthesis 5.0 538.0 519.0 6.0 0.943859649122807 I 178.0 380.0 8.0 0.868421052631579 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 558.0 0.3189964157706093 0.6810035842293907 0.0734539672128241 0.530564020526536 0.30200899386968 0.4571100533137118 0 0 0 0 K19303 0.0 0.0284900284900284 mepH; murein DD-endopeptidase [EC:3.4.-.-] 90.0 13.0 12.0 2.0 0.928571428571429 M 0.0 14.0 2.0 0.928571428571429 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 14.0 0.0 1.0 0.60651804534944 0.0259170714506402 0.31621755840004 0.5806009738987998 0 0 0 1 K19304 0.0 0.0427350427350427 mepM; murein DD-endopeptidase [EC:3.4.24.-] 232.0 16.0 0.0 1.0 1.0 M 0.0 16.0 2.0 0.9375 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 16.0 0.0 1.0 0.027588569566844 0.0644000192974604 0.0459942944321522 0.0368114497306164 0 0 0 0 K19306 0.0285714285714285 0.0 BUD23; 18S rRNA (guanine1575-N7)-methyltransferase [EC:2.1.1.309] 180.0 14.0 0.0 1.0 1.0 Q 14.0 0.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 14.0 1.0 0.0 0.0497548141917588 0.0006475093488374 0.0252011617702981 0.0491073048429214 0 0 0 0 K19309 0.0028571428571428 0.0313390313390313 bcrA; bacitracin transport system ATP-binding protein path:map02010 ABC transporters 299.0 15.0 0.0 1.0 1.0 V 1.0 14.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 15.0 0.0666666666666666 0.9333333333333332 0.0217236930570291 0.0953607883072158 0.0585422406821224 0.0736370952501866 0 0 0 0 K19310 0.0 0.0313390313390313 bcrB; bacitracin transport system permease protein path:map02010 ABC transporters 177.0 8.0 3.0 3.0 0.533333333333333 S 0.0 15.0 3.0 0.533333333333333 COG4200 Predicted_lantabiotic-exporting_membrane_pepmease,_EfiE/EfiG/ABC2_family EfiE 15.0 0.0 1.0 0.020118057355903 0.0407612346127208 0.0304396459843118 0.0206431772568178 0 0 0 0 K19311 0.0 0.0199430199430199 lipV; lipase [EC:3.1.1.-] 234.0 6.0 5.0 2.0 0.857142857142857 S 0.0 7.0 2.0 0.857142857142857 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 7.0 0.0 1.0 0.0388136219395163 0.0850383342774988 0.0619259781085075 0.0462247123379825 0 0 0 0 K19312 0.1142857142857142 0.0028490028490028 pccB; acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] path:map00280,path:map00630,path:map00640,path:map01100,path:map01110,path:map01120,path:map01200 Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism 509.0 47.0 0.0 1.0 1.0 I 46.0 1.0 1.0 1.0 COG4799 Acetyl-CoA_carboxylase,_carboxyltransferase_component MmdA 47.0 0.9787234042553192 0.0212765957446808 0.001597561286326 0.017777090692348 0.009687325989337 0.016179529406022 0 0 0 0 K19321 0.0 0.0028490028490028 blaOXA-214; beta-lactamase class D OXA-214 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 265.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 1.0 0.0 1.0 0 0 0 0 K19333 0.0 0.0484330484330484 kdgR; IclR family transcriptional regulator, KDG regulon repressor 219.0 19.0 0.0 1.0 1.0 K 0.0 19.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 19.0 0.0 1.0 0.0289756449947913 0.0646076431440408 0.046791644069416 0.0356319981492495 0 0 0 0 K19334 0.0 0.0113960113960113 tabA; biofilm protein TabA 144.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG2731 Beta-galactosidase,_beta_subunit EbgC 4.0 0.0 1.0 0.0154188344672292 0.030173266264305 0.0227960503657671 0.0147544317970757 0 0 0 0 K19335 0.0 0.0085470085470085 bdcR; TetR/AcrR family transcriptional regulator, repressor for divergent bdcA 184.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 6.0 0.0 1.0 1.37878819120761e-12 2.72887807695786e-12 2.053833134082735e-12 1.35008988575025e-12 0 0 0 0 K19336 0.0 0.0142450142450142 bdcA; cyclic-di-GMP-binding biofilm dispersal mediator protein 237.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0087640511997673 0.0334913135603717 0.0211276823800695 0.0247272623606044 0 0 0 0 K19337 0.0 0.0455840455840455 hexR; RpiR family transcriptional regulator, carbohydrate utilization regulator 275.0 18.0 0.0 1.0 1.0 K 0.0 18.0 1.0 1.0 COG1737 DNA-binding_transcriptional_regulator,_MurR/RpiR_family,_contains_HTH_and_SIS_domains RpiR 18.0 0.0 1.0 0.0047978279642819 0.0062573851826953 0.0055276065734885 0.0014595572184133 0 0 0 0 K19338 0.0 0.0484330484330484 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein 203.0 31.0 0.0 1.0 1.0 K 0.0 31.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 31.0 0.0 1.0 0.0023331166132761 0.0046786068936884 0.0035058617534822 0.0023454902804123 0 0 0 0 K19339 0.0028571428571428 0.0455840455840455 nosR; NosR/NirI family transcriptional regulator, nitrous oxide reductase regulator 275.0 19.0 17.0 2.0 0.904761904761905 CK 1.0 20.0 2.0 0.857142857142857 COG0348 Polyferredoxin_NapH NapH 21.0 0.0476190476190476 0.9523809523809524 0.0447714870844761 0.103691365310286 0.074231426197381 0.0589198782258099 0 0 0 0 K19340 0.0828571428571428 0.1082621082621082 nosF; Cu-processing system ATP-binding protein path:map02010 ABC transporters 177.0 58.0 46.0 2.0 0.828571428571429 V 31.0 39.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 70.0 0.4428571428571428 0.5571428571428572 0.32809347365115 0.239128425312539 0.2836109494818445 0.0889650483386109 0 0 0 0 K19341 0.08 0.1139601139601139 nosY; Cu-processing system permease protein path:map02010 ABC transporters 195.0 54.0 0.0 1.0 1.0 S 29.0 42.0 3.0 0.971830985915493 COG1277 ABC-type_transport_system_involved_in_multi-copper_enzyme_maturation,_permease_component NosY 71.0 0.4084507042253521 0.5915492957746479 0.900350588438862 0.986533310871342 0.943441949655102 0.08618272243248 1 1 1 1 K19342 0.0 0.0911680911680911 nosL; copper chaperone NosL 59.0 45.0 0.0 1.0 1.0 C 0.0 45.0 1.0 1.0 COG4314 Nitrous_oxide_reductase_accessory_protein_NosL NosL 45.0 0.0 1.0 0.10032175350229 0.295184846071966 0.197753299787128 0.194863092569676 0 0 0 0 K19343 0.0 0.0085470085470085 nirI; NosR/NirI family transcriptional regulator, nitrite reductase regulator 101.0 6.0 0.0 1.0 1.0 CK 0.0 6.0 2.0 0.5 COG0348 Polyferredoxin_NapH NapH 6.0 0.0 1.0 0.0134698583101174 0.0223666146688746 0.017918236489496 0.0088967563587572 0 0 0 0 K19344 0.0 0.017094017094017 nirC; cytochrome c55X 97.0 6.0 0.0 1.0 1.0 C 0.0 6.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 6.0 0.0 1.0 0.133646684822855 0.235744470354367 0.184695577588611 0.102097785531512 0 0 0 0 K19345 0.0 0.0341880341880341 nirF; protein NirF 352.0 10.0 9.0 3.0 0.833333333333333 S 0.0 12.0 1.0 1.0 COG3391 DNA-binding_beta-propeller_fold_protein_YncE YncE 12.0 0.0 1.0 0.174496676929927 0.0620449846140335 0.1182708307719802 0.1124516923158935 0 0 0 0 K19347 0.0057142857142857 0.0028490028490028 SUN1_2; SUN domain-containing protein 1/2 189.0 2.0 1.0 2.0 0.666666666666667 G 2.0 1.0 2.0 0.666666666666667 COG0153 Galactokinase GalK 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K19349 0.0 0.0142450142450142 vga; pleuromutilin/lincosamide/streptogramin A transport system ATP-binding/permease protein path:map02010 ABC transporters 451.0 5.0 4.0 2.0 0.833333333333333 S 0.0 6.0 1.0 1.0 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 6.0 0.0 1.0 0.0073134934134413 0.0168206440232352 0.0120670687183382 0.0095071506097939 0 0 0 0 K19350 0.0 0.0569800569800569 lsa; lincosamide and streptogramin A transport system ATP-binding/permease protein path:map02010 ABC transporters 426.0 18.0 16.0 2.0 0.9 S 0.0 20.0 1.0 1.0 COG0488 ATPase_components_of_ABC_transporters_with_duplicated_ATPase_domains Uup 20.0 0.0 1.0 0.107189847191543 0.539311657632928 0.3232507524122355 0.432121810441385 0 0 0 0 K19351 0.0028571428571428 0.0028490028490028 mpl; zinc metalloproteinase [EC:3.4.24.-] 75.0 2.0 0.0 1.0 1.0 E 1.0 1.0 2.0 0.5 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 2.0 0.5 0.5 0 0 0 0 K19353 0.0 0.0484330484330484 eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-] path:map00540 Lipopolysaccharide biosynthesis 104.0 24.0 19.0 2.0 0.827586206896552 S 0.0 29.0 1.0 1.0 COG2194 Phosphoethanolamine_transferase_for_periplasmic_glucans_OpgE,_AlkP_superfamily OpgE 29.0 0.0 1.0 0.0063833454708424 0.0140585904886497 0.010220967979746 0.0076752450178073 0 0 0 0 K19354 0.0028571428571428 0.0227920227920227 waaH; heptose III glucuronosyltransferase [EC:2.4.1.-] path:map00540 Lipopolysaccharide biosynthesis 177.0 7.0 5.0 2.0 0.777777777777778 M 1.0 8.0 3.0 0.555555555555556 COG1216 Glycosyltransferase,_GT2_family WcaE 9.0 0.1111111111111111 0.8888888888888888 0.0914837848239824 0.177555642256595 0.1345197135402887 0.0860718574326126 0 0 0 0 K19355 0.0171428571428571 0.0512820512820512 MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 112.0 28.0 27.0 3.0 0.933333333333333 G 8.0 22.0 3.0 0.866666666666667 COG3934 Endo-1,4-beta-mannosidase 30.0 0.2666666666666666 0.7333333333333333 0.0552324481603957 0.154779448173168 0.1050059481667818 0.0995470000127723 0 0 0 0 K19360 0.0 0.0028490028490028 NPHP3; nephrocystin-3 966.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K19373 0.0028571428571428 0.0113960113960113 DNAJC28; DnaJ homolog subfamily C member 28 146.0 3.0 1.0 2.0 0.6 S 1.0 4.0 2.0 0.6 2DRW3 5.0 0.2 0.8 0.13761737313727 0.649477191624712 0.3935472823809909 0.511859818487442 0 0 0 0 K19405 0.0 0.1994301994301994 mcsB; protein arginine kinase [EC:2.7.14.1] 225.0 43.0 18.0 4.0 0.56578947368421 E 0.0 76.0 2.0 0.881578947368421 COG3869 Protein-arginine_kinase_McsB McsB 76.0 0.0 1.0 0.824454912190115 0.358031301735291 0.591243106962703 0.466423610454824 0 0 1 1 K19411 0.0 0.2022792022792023 mcsA; protein arginine kinase activator 84.0 65.0 56.0 2.0 0.878378378378378 S 0.0 74.0 1.0 1.0 COG3880 Protein-arginine_kinase_activator_protein_McsA McsA 74.0 0.0 1.0 0.0363504080975679 0.0804290993462233 0.0583897537218956 0.0440786912486554 0 0 0 0 K19412 0.0628571428571428 0.0 argX; glutamate---[amino group carrier protein] ligase [EC:6.3.2.60] path:map00220,path:map01100,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 247.0 20.0 12.0 2.0 0.714285714285714 H 28.0 0.0 1.0 1.0 COG0189 Glutathione_synthase,_LysX_or_RimK-type_ligase,_ATP-grasp_superfamily LysX 28.0 1.0 0.0 0.442405753539504 0.887593071430006 0.664999412484755 0.445187317890502 0 0 0 0 K19416 0.0085714285714285 0.1111111111111111 yccA; modulator of FtsH protease 172.0 40.0 35.0 2.0 0.888888888888889 S 3.0 42.0 1.0 1.0 COG0670 Integral_membrane_protein_YbhL,_putative_Ca2+_regulator,_Bax_inhibitor_(BI-1)/TMBIM_family YbhL 45.0 0.0666666666666666 0.9333333333333332 0.0075835021064011 0.0271182726248424 0.0173508873656217 0.0195347705184412 0 0 0 0 K19417 0.0 0.0113960113960113 slrR; HTH-type transcriptional regulator, biofilm formation regulator 62.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 4.0 0.0 1.0 0.0094835073668486 0.0145243428139306 0.0120039250903896 0.005040835447082 0 0 0 0 K19418 0.0228571428571428 0.0056980056980056 epsK; membrane protein EpsK 501.0 12.0 0.0 1.0 1.0 S 10.0 2.0 1.0 1.0 arCOG02210 12.0 0.8333333333333334 0.1666666666666666 0.0449047594062987 0.0776330256968227 0.0612688925515607 0.032728266290524 0 0 0 0 K19419 0.0 0.017094017094017 epsG; transmembrane protein EpsG 315.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 2DR4Q 6.0 0.0 1.0 0.0175579939774726 0.0388315128005448 0.0281947533890087 0.0212735188230722 0 0 0 0 K19420 0.0 0.0028490028490028 epsA, capA; protein tyrosine kinase modulator 248.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG3944 Capsular_polysaccharide_biosynthesis_protein_YveK YveK 1.0 0.0 1.0 0 0 0 0 K19421 0.0 0.037037037037037 epsC; polysaccharide biosynthesis protein EpsC 559.0 14.0 0.0 1.0 1.0 GM 0.0 14.0 1.0 1.0 COG1086 NDP-sugar_epimerase,_includes_UDP-GlcNAc-inverting_4,6-dehydratase_FlaA1_and_capsular_polysaccharide_biosynthesis_protein_EpsC FlaA1 14.0 0.0 1.0 0.16686039020978 0.0244899654913823 0.0956751778505811 0.1423704247183977 0 0 0 0 K19422 0.0085714285714285 0.037037037037037 epsD; glycosyltransferase EpsD [EC:2.4.-.-] 310.0 16.0 14.0 2.0 0.888888888888889 M 3.0 15.0 2.0 0.888888888888889 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 18.0 0.1666666666666666 0.8333333333333334 0.345430862218767 0.257831433781422 0.3016311480000945 0.087599428437345 0 0 0 0 K19423 0.0 0.0028490028490028 epsE; glycosyltransferase EpsE [EC:2.4.-.-] 289.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 1.0 0.0 1.0 0 0 0 0 K19424 0.0 0.0569800569800569 epsF; glycosyltransferase EpsF [EC:2.4.-.-] 231.0 22.0 0.0 1.0 1.0 M 0.0 22.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 22.0 0.0 1.0 0.0239286428178722 0.0663577649841877 0.0451432039010299 0.0424291221663155 0 0 0 0 K19425 0.0 0.0028490028490028 epsH; glycosyltransferase EpsH [EC:2.4.-.-] 335.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 1.0 0.0 1.0 0 0 0 0 K19426 0.0028571428571428 0.0028490028490028 epsI; pyruvyl transferase EpsI [EC:2.-.-.-] 234.0 2.0 0.0 1.0 1.0 GM 1.0 1.0 1.0 1.0 COG5039 Exopolysaccharide_biosynthesis_protein_EpsI,_predicted_pyruvyl_transferase EpsI 2.0 0.5 0.5 0 0 0 0 K19427 0.0 0.0113960113960113 epsJ; glycosyltransferase EpsJ [EC:2.4.-.-] 294.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 4.0 0.0 1.0 0.0617506282765046 0.137979684161883 0.0998651562191938 0.0762290558853784 0 0 0 0 K19428 0.0 0.0512820512820512 epsL; sugar transferase EpsL [EC:2.-.-.-] 169.0 19.0 0.0 1.0 1.0 M 0.0 19.0 2.0 0.947368421052632 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 19.0 0.0 1.0 0.765252577413266 0.148585563232579 0.4569190703229225 0.616667014180687 0 0 1 1 K19429 0.0028571428571428 0.0455840455840455 epsM; acetyltransferase EpsM [EC:2.3.1.-] 165.0 11.0 4.0 3.0 0.578947368421053 S 1.0 18.0 1.0 1.0 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 19.0 0.0526315789473684 0.9473684210526316 0.0383471742202025 0.157031651283465 0.0976894127518337 0.1186844770632624 0 0 0 0 K19430 0.0 0.0341880341880341 epsN; pyridoxal phosphate-dependent aminotransferase EpsN [EC:2.6.1.-] 363.0 12.0 10.0 2.0 0.857142857142857 E 0.0 14.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 14.0 0.0 1.0 0.0260385374816586 0.316848745005573 0.1714436412436157 0.2908102075239144 0 0 0 0 K19431 0.0 0.0227920227920227 epsO; pyruvyl transferase EpsO [EC:2.-.-.-] 243.0 6.0 4.0 2.0 0.75 GM 0.0 8.0 2.0 0.75 COG5039 Exopolysaccharide_biosynthesis_protein_EpsI,_predicted_pyruvyl_transferase EpsI 8.0 0.0 1.0 0.072788675643634 0.148380622815188 0.110584649229411 0.0755919471715539 0 0 0 0 K19433 0.0 0.0056980056980056 tapA; TasA anchoring/assembly protein 263.0 0.0 2.0 1.0 1.0 2DM3Y 2.0 0.0 1.0 0 0 0 0 K19449 0.0 0.037037037037037 sinR; XRE family transcriptional regulator, master regulator for biofilm formation 62.0 19.0 0.0 1.0 1.0 K 0.0 19.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 19.0 0.0 1.0 0.0129278342451523 0.0369042273149635 0.0249160307800579 0.0239763930698111 0 0 0 0 K19465 0.0257142857142857 0.017094017094017 MGME1, DDK1; mitochondrial genome maintenance exonuclease 1 [EC:3.1.-.-] 127.0 14.0 13.0 2.0 0.933333333333333 L 9.0 6.0 3.0 0.533333333333333 COG1468 CRISPR/Cas_system-associated_exonuclease_Cas4,_RecB_family Cas4 15.0 0.6 0.4 0.0881097936478787 0.34228553996373 0.2151976668058043 0.2541757463158513 0 0 0 0 K19477 0.0 0.0028490028490028 PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12] path:map04022,path:map04540,path:map04611,path:map04713,path:map04714,path:map04730,path:map04740,path:map04923,path:map04924,path:map04970 cGMP-PKG signaling pathway,Gap junction,Platelet activation,Circadian entrainment,Thermogenesis,Long-term depression,Olfactory transduction,Regulation of lipolysis in adipocytes,Renin secretion,Salivary secretion 321.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 1.0 0.0 1.0 0 0 0 0 K19504 0.0 0.0199430199430199 gfrE; glucoselysine-6-phosphate deglycase 111.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG0449 Glucosamine_6-phosphate_synthetase,_contains_amidotransferase_and_phosphosugar_isomerase_domains GlmS 7.0 0.0 1.0 0.102419892428178 0.210237321250456 0.1563286068393169 0.1078174288222779 0 0 0 0 K19505 0.0 0.0142450142450142 gfrR; sigma-54 dependent transcriptional regulator, gfr operon transcriptional activator 839.0 5.0 0.0 1.0 1.0 K 0.0 5.0 2.0 0.8 COG1221 Transcriptional_regulators_containing_an_AAA-type_ATPase_domain_and_a_DNA-binding_domain PspF 5.0 0.0 1.0 0.0636153329379375 0.186925175326537 0.1252702541322372 0.1233098423885994 0 0 0 0 K19506 0.0 0.0028490028490028 gfrA; fructoselysine/glucoselysine PTS system EIIA component [EC:2.7.1.-] path:map02060 Phosphotransferase system (PTS) 172.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG2893 Phosphotransferase_system,_mannose/fructose-specific_component_IIA ManX 1.0 0.0 1.0 0 0 0 0 K19507 0.0 0.0256410256410256 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] path:map02060 Phosphotransferase system (PTS) 154.0 8.0 0.0 1.0 1.0 G 0.0 9.0 2.0 0.888888888888889 COG3444 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_component_IIB AgaB 9.0 0.0 1.0 0.0471109705743985 0.0802843662255023 0.0636976683999503 0.0331733956511037 0 0 0 0 K19508 0.0 0.0142450142450142 gfrC; fructoselysine/glucoselysine PTS system EIIC component path:map02060 Phosphotransferase system (PTS) 248.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG3715 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IIC_component ManY 5.0 0.0 1.0 0.132394270966228 0.247846903384109 0.1901205871751685 0.115452632417881 0 0 0 0 K19509 0.0 0.0199430199430199 gfrD; fructoselysine/glucoselysine PTS system EIID component path:map02060 Phosphotransferase system (PTS) 262.0 7.0 0.0 1.0 1.0 G 0.0 7.0 1.0 1.0 COG3716 Phosphotransferase_system,_mannose/fructose/N-acetylgalactosamine-specific_IID_component ManZ 7.0 0.0 1.0 0.109939859672381 0.252056561564215 0.180998210618298 0.142116701891834 0 0 0 0 K19510 0.0 0.0199430199430199 gfrF; fructoselysine-6-phosphate deglycase 330.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG2222 Fructoselysine-6-P-deglycase_FrlB_or_related_protein,_duplicated_sugar_isomerase_(SIS)_domain AgaS 7.0 0.0 1.0 0.070037355921618 0.136419239747167 0.1032282978343925 0.0663818838255489 0 0 0 0 K19511 0.0 0.0056980056980056 PXDN, VPO1; peroxidase [EC:1.11.1.7] 71.0 2.0 1.0 2.0 0.666666666666667 C 0.0 3.0 1.0 1.0 COG2931 Ca2+-binding_protein,_RTX_toxin-related 3.0 0.0 1.0 0 0 0 0 K19515 0.0685714285714285 0.0199430199430199 bamB; benzoyl-CoA reductase subunit BamB [EC:1.3.-.-] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 457.0 48.0 0.0 1.0 1.0 C 39.0 9.0 1.0 1.0 COG2414 Aldehyde:ferredoxin_oxidoreductase YdhV 48.0 0.8125 0.1875 0.924980187182343 0.986043483552477 0.95551183536741 0.0610632963701339 1 1 1 1 K19516 0.0 0.0113960113960113 bamC; benzoyl-CoA reductase subunit BamC [EC:1.3.-.-] path:map00362,path:map01100,path:map01120,path:map01220 Benzoate degradation,Metabolic pathways,Microbial metabolism in diverse environments,Degradation of aromatic compounds 131.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1142 Fe-S-cluster-containing_hydrogenase_component_2 HycB 5.0 0.0 1.0 4.45876360099867e-06 0.00161999333887 0.0008122260512354 0.001615534575269 0 0 0 0 K19517 0.0028571428571428 0.0056980056980056 MIK; 1D-myo-inositol 3-kinase [EC:2.7.1.64] path:map00562,path:map01100,path:map01110 Inositol phosphate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 249.0 3.0 0.0 1.0 1.0 G 1.0 2.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K19519 0.0057142857142857 0.0313390313390313 TGFBI, BIGH3; transforming growth factor-beta-induced protein 144.0 14.0 13.0 3.0 0.875 M 3.0 13.0 2.0 0.9375 COG2335 Uncaracterized_surface_protein_containing_fasciclin_(FAS1)_repeats FAS1 16.0 0.1875 0.8125 0.0202486986523039 0.0669319413536156 0.0435903200029597 0.0466832427013117 0 0 0 0 K19540 0.0028571428571428 0.017094017094017 frlA; fructoselysine transporter 231.0 7.0 0.0 1.0 1.0 E 1.0 6.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 7.0 0.1428571428571428 0.8571428571428571 0.0205290239552316 0.0597823771937061 0.0401557005744688 0.0392533532384744 0 0 0 0 K19545 0.0 0.0341880341880341 lnuA_C_D_E, lin; lincosamide nucleotidyltransferase A/C/D/E 86.0 12.0 0.0 1.0 1.0 J 0.0 12.0 1.0 1.0 COG0617 tRNA_nucleotidyltransferase/poly(A)_polymerase PcnB 12.0 0.0 1.0 0.990769312087198 0.698823726013443 0.8447965190503205 0.291945586073755 0 0 1 1 K19547 0.0142857142857142 0.0199430199430199 bacB; 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase [EC:5.3.3.19] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 75.0 7.0 1.0 5.0 0.4375 L 5.0 11.0 2.0 0.875 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 16.0 0.3125 0.6875 0.123802642578309 0.498196789537914 0.3109997160581115 0.374394146959605 0 0 0 0 K19548 0.0371428571428571 0.0256410256410256 bacC; dihydroanticapsin dehydrogenase [EC:1.1.1.385] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 220.0 24.0 0.0 1.0 1.0 IQ 14.0 10.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 24.0 0.5833333333333334 0.4166666666666667 0.0385048202455968 0.220718631519855 0.1296117258827259 0.1822138112742581 0 0 0 0 K19549 0.0 0.0028490028490028 bacF; bacilysin biosynthesis transaminase BacF [EC:2.6.1.-] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 385.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 1.0 0.0 1.0 0 0 0 0 K19550 0.0 0.017094017094017 bacG; bacilysin biosynthesis oxidoreductase BacG [EC:1.3.1.-] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 147.0 5.0 3.0 2.0 0.714285714285714 IQ 0.0 7.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 7.0 0.0 1.0 0.0107848572288699 0.061992252328826 0.0363885547788479 0.0512073950999561 0 0 0 0 K19551 0.0 0.0085470085470085 pelC; pectate lyase C [EC:4.2.2.2 4.2.2.10] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 66.0 4.0 0.0 1.0 1.0 G 0.0 4.0 2.0 0.75 COG3507 Beta-xylosidase XynB2 4.0 0.0 1.0 0.91887914573123 0.138683985773391 0.5287815657523105 0.780195159957839 0 0 1 1 K19552 0.0028571428571428 0.0056980056980056 bacE; MFS transporter, DHA3 family, bacilysin exporter BacE 275.0 3.0 0.0 1.0 1.0 EGP 1.0 2.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K19560 0.0 0.0113960113960113 bioK; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 145.0 2.0 0.0 2.0 0.5 S 0.0 4.0 2.0 0.5 COG0400 Predicted_esterase YpfH 4.0 0.0 1.0 0.0321962470429288 0.0479096023769165 0.0400529247099226 0.0157133553339877 0 0 0 0 K19563 0.0 0.017094017094017 bioA, bioK; lysine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.105] path:map00780,path:map01100,path:map01240 Biotin metabolism,Metabolic pathways,Biosynthesis of cofactors 444.0 6.0 0.0 1.0 1.0 H 0.0 6.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 6.0 0.0 1.0 0.0601729249705858 0.157809694207466 0.1089913095890258 0.0976367692368802 0 0 0 0 K19569 0.0 0.0085470085470085 elmMIII; 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase [EC:2.1.1.307] path:map01057,path:map01100,path:map01110 Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 239.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 3.0 0.0 1.0 0 0 0 0 K19572 0.0 0.0256410256410256 CECR1, ADA2; adenosine deaminase CECR1 [EC:3.5.4.4] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 277.0 9.0 0.0 1.0 1.0 F 0.0 9.0 1.0 1.0 COG1816 Adenosine_deaminase Add 9.0 0.0 1.0 0.168577385004606 0.338701817966114 0.25363960148536 0.1701244329615079 0 0 0 0 K19575 0.0 0.0056980056980056 bmrR; MerR family transcriptional regulator, activator of bmr gene 259.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 2.0 0.0 1.0 0 0 0 0 K19576 0.0628571428571428 0.0256410256410256 norA; MFS transporter, DHA1 family, quinolone resistance protein 274.0 27.0 20.0 2.0 0.794117647058823 EGP 25.0 9.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 34.0 0.7352941176470589 0.2647058823529412 0 0 0 0 K19577 0.0085714285714285 0.1595441595441595 ydhP; MFS transporter, DHA1 family, inner membrane transport protein 343.0 86.0 83.0 4.0 0.934782608695652 EGP 3.0 89.0 2.0 0.967391304347826 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 92.0 0.0326086956521739 0.967391304347826 0 0 0 0 K19578 0.0085714285714285 0.0284900284900284 bmr; MFS transporter, DHA1 family, multidrug resistance protein 364.0 13.0 0.0 1.0 1.0 EGP 3.0 10.0 1.0 1.0 COG0477 MFS_family_permease,_includes_anhydromuropeptide_permease_AmpG ProP 13.0 0.2307692307692307 0.7692307692307693 0 0 0 0 K19580 0.0 0.0113960113960113 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] 342.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG3424 Predicted_naringenin-chalcone_synthase BH0617 4.0 0.0 1.0 0.0061528157692926 0.0198087582435759 0.0129807870064342 0.0136559424742833 0 0 0 0 K19585 0.0 0.0227920227920227 oqxB; multidrug efflux pump 1016.0 9.0 8.0 2.0 0.9 V 0.0 10.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 10.0 0.0 1.0 0.0101691583052434 0.0109052722384258 0.0105372152718345 0.0007361139331824 0 0 0 0 K19586 0.0 0.0199430199430199 oqxA; membrane fusion protein, multidrug efflux system 366.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 7.0 0.0 1.0 0.0102071689703696 0.014271756818542 0.0122394628944558 0.0040645878481724 0 0 0 0 K19587 0.0 0.0199430199430199 oqxR; Rrf2 family transcriptional regulator, repressor of oqxAB 137.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1959 DNA-binding_transcriptional_regulator,_IscR_family IscR 7.0 0.0 1.0 0.0320457651698198 0.0665989826581482 0.049322373913984 0.0345532174883284 0 0 0 0 K19588 0.06 0.0 dopDH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] path:map00040,path:map00053,path:map00470,path:map01100 Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,D-Amino acid metabolism,Metabolic pathways 475.0 32.0 0.0 1.0 1.0 C 32.0 0.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 32.0 1.0 0.0 0.0264607524142344 0.0283815282324382 0.0274211403233363 0.0019207758182037 0 0 0 0 K19589 0.0028571428571428 0.0 N6AMT1; release factor glutamine methyltransferase [EC:2.1.1.297] 223.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 1.0 1.0 0.0 0 0 0 0 K19590 0.0114285714285714 0.0 araDH; D-arabinose 1-dehydrogenase (NADP+) [EC:1.1.1.427] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 338.0 4.0 0.0 1.0 1.0 C 4.0 0.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 4.0 1.0 0.0 0.0243808128061986 0.038732449135463 0.0315566309708308 0.0143516363292643 0 0 0 0 K19591 0.0 0.2136752136752136 cueR; MerR family transcriptional regulator, copper efflux regulator 79.0 105.0 104.0 2.0 0.990566037735849 K 0.0 106.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 106.0 0.0 1.0 0.00405835660486 0.0390978234883211 0.0215780900465905 0.0350394668834611 0 0 0 0 K19592 0.0 0.017094017094017 golS; MerR family transcriptional regulator, gold-responsive activator of gol and ges genes 134.0 8.0 0.0 1.0 1.0 K 0.0 8.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 8.0 0.0 1.0 0.0159683549726593 0.0316149077480241 0.0237916313603417 0.0156465527753647 0 0 0 0 K19593 0.0 0.0056980056980056 opmE; outer membrane protein, multidrug efflux system 473.0 2.0 0.0 1.0 1.0 MU 0.0 2.0 1.0 1.0 COG1538 Outer_membrane_protein_TolC TolC 2.0 0.0 1.0 0 0 0 0 K19594 0.0 0.0028490028490028 gesB, mexQ; gold/copper resistance efflux pump 1046.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 1.0 0.0 1.0 0 0 0 0 K19595 0.0 0.0056980056980056 gesA, mexP; membrane fusion protein, gold/copper resistance efflux system 109.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 2.0 0.0 1.0 0 0 0 0 K19597 0.0 0.017094017094017 golT; Au+-exporting ATPase [EC:3.6.1.-] 812.0 6.0 0.0 1.0 1.0 P 0.0 6.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 6.0 0.0 1.0 0.0530382983820401 0.117022884799081 0.0850305915905605 0.0639845864170409 0 0 0 0 K19609 0.0 0.0085470085470085 pfeS, pirS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3] path:map02020 Two-component system 427.0 5.0 0.0 1.0 1.0 T 0.0 5.0 3.0 0.4 COG2770 HAMP_domain HAMP 5.0 0.0 1.0 0.0054331457354201 0.0126807152945176 0.0090569305149688 0.0072475695590975 0 0 0 0 K19610 0.0 0.0199430199430199 pfeR, pirR; two-component system, OmpR family, response regulator PfeR path:map02020 Two-component system 220.0 6.0 5.0 2.0 0.857142857142857 K 0.0 7.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 7.0 0.0 1.0 0.004661954387577 0.0122490253026013 0.0084554898450891 0.0075870709150243 0 0 0 0 K19611 0.0 0.0085470085470085 fepA, pfeA, iroN, pirA; ferric enterobactin receptor path:map02020 Two-component system 607.0 4.0 0.0 1.0 1.0 P 0.0 4.0 1.0 1.0 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 4.0 0.0 1.0 0.0635669299343099 0.133337211379315 0.0984520706568124 0.0697702814450051 0 0 0 0 K19613 0.0 0.0028490028490028 SHOC2, SUR8; leucine-rich repeat protein SHOC2 path:map04014 Ras signaling pathway 827.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3878 Uncharacterized_conserved_protein_YwqG,_DUF1963_family YwqG 1.0 0.0 1.0 0 0 0 0 K19615 0.0 0.0085470085470085 fitD, mcf; insecticidal toxin path:map02020 Two-component system 132.0 5.0 4.0 3.0 0.714285714285714 Q 0.0 7.0 2.0 0.857142857142857 COG2931 Ca2+-binding_protein,_RTX_toxin-related 7.0 0.0 1.0 2.97629161603673e-13 0.0030027925904021 0.0015013962953498 0.0030027925901044 0 0 0 0 K19616 0.0 0.0056980056980056 fitF; two-component system, sensor histidine kinase and response regulator FitF [EC:2.7.13.3] path:map02020 Two-component system 727.0 5.0 0.0 1.0 1.0 T 0.0 5.0 3.0 0.4 COG4251 Bacteriophytochrome_(light-regulated_signal_transduction_histidine_kinase) 5.0 0.0 1.0 3.44914780038482e-13 0.0025015718540085 0.0012507859271767 0.0025015718536635 0 0 0 0 K19617 0.0 0.0028490028490028 fitH; two-component system, response regulator FitH path:map02020 Two-component system 373.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG3437 Response_regulator_c-di-GMP_phosphodiesterase,_RpfG_family,_contains_REC_and_HD-GYP_domains RpfG 1.0 0.0 1.0 0 0 0 0 K19620 0.0 0.0199430199430199 phcB; extracellular factor (EF) 3-hydroxypalmitic acid methyl ester biosynthesis protein path:map02020 Two-component system 99.0 8.0 0.0 1.0 1.0 Q 0.0 8.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 8.0 0.0 1.0 0.0099457820820739 0.0332216167110783 0.0215836993965761 0.0232758346290044 0 0 0 0 K19622 0.0 0.0227920227920227 phcR; two-component system, response regulator PhcR path:map02020 Two-component system 156.0 11.0 0.0 1.0 1.0 T 0.0 11.0 5.0 0.272727272727273 COG0784 CheY-like_REC_(receiver)_domain,_includes_chemotaxis_protein_CheY__and_sporulation_regulator_Spo0F CheY 11.0 0.0 1.0 0.0059468060892144 0.0137137380712796 0.009830272080247 0.0077669319820651 0 0 0 0 K19623 0.0 0.0028490028490028 phcQ; two-component system, probable response regulator PhcQ 350.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG3437 Response_regulator_c-di-GMP_phosphodiesterase,_RpfG_family,_contains_REC_and_HD-GYP_domains RpfG 2.0 0.0 1.0 0 0 0 0 K19628 0.0 0.0028490028490028 CYP158A1; biflaviolin synthase [EC:1.14.19.69] 389.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K19633 0.0 0.0056980056980056 sr; sorbose reductase [EC:1.1.1.289] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 453.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG0246 Mannitol-1-phosphate/altronate_dehydrogenases MtlD 2.0 0.0 1.0 0 0 0 0 K19640 0.0 0.0455840455840455 hypX, hoxX; putative two-component system protein, hydrogenase maturation factor HypX/HoxX 100.0 7.0 1.0 3.0 0.4375 S 0.0 16.0 3.0 0.5 COG0223 Methionyl-tRNA_formyltransferase Fmt 16.0 0.0 1.0 0.0507938025230854 0.1588371618591 0.1048154821910927 0.1080433593360145 0 0 0 0 K19641 0.0 0.0541310541310541 hupR, hoxA; two-component system, NtrC family, response regulator HupR/HoxA path:map02020 Two-component system 422.0 20.0 0.0 1.0 1.0 T 0.0 20.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 20.0 0.0 1.0 0.0110275726327599 0.165159876956426 0.0880937247945929 0.1541323043236661 0 0 0 0 K19647 0.0057142857142857 0.0142450142450142 hgd; 2-hydroxymethylglutarate dehydrogenase [EC:1.1.1.291] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 270.0 7.0 5.0 2.0 0.777777777777778 I 3.0 6.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 9.0 0.3333333333333333 0.6666666666666666 0.0084697544953468 0.0387843829984777 0.0236270687469122 0.0303146285031309 0 0 0 0 K19653 0.0 0.0028490028490028 geoA; geraniol dehydrogenase (NAD+) [EC:1.1.1.347] path:map00281,path:map01110 Geraniol degradation,Biosynthesis of secondary metabolites 365.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1062 Zn-dependent_alcohol/formaldehyde_dehydrogenase FrmA 1.0 0.0 1.0 0 0 0 0 K19659 0.0028571428571428 0.0056980056980056 phaJ; enoyl-CoA hydratase [EC:4.2.1.119] 79.0 3.0 0.0 1.0 1.0 I 1.0 2.0 1.0 1.0 COG2030 Acyl-CoA_dehydratase_PaaZ MaoC 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K19660 0.0457142857142857 0.0028490028490028 araDH; L-arabinose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.376] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 249.0 18.0 0.0 1.0 1.0 M 17.0 1.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 18.0 0.9444444444444444 0.0555555555555555 0.0126168432791517 0.0175861797687236 0.0151015115239376 0.0049693364895719 0 0 0 0 K19661 0.0 0.0341880341880341 hupT, hoxJ; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3] path:map02020 Two-component system 396.0 12.0 11.0 2.0 0.923076923076923 T 0.0 13.0 3.0 0.846153846153846 COG4191 Signal_transduction_histidine_kinase_regulating_C4-dicarboxylate_transport_system 13.0 0.0 1.0 0.0080053381776661 0.0206617020742977 0.0143335201259819 0.0126563638966316 0 0 0 0 K19664 0.7371428571428571 0.0199430199430199 carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 117.0 267.0 0.0 1.0 1.0 I 260.0 7.0 1.0 1.0 COG0575 CDP-diglyceride_synthetase CdsA 267.0 0.9737827715355806 0.0262172284644194 0.267071304613997 0.0445228017797067 0.1557970531968518 0.2225485028342902 0 0 0 0 K19665 0.0371428571428571 0.0 pssA; archaetidylserine synthase [EC:2.7.8.38] path:map00564,path:map01110 Glycerophospholipid metabolism,Biosynthesis of secondary metabolites 161.0 13.0 0.0 1.0 1.0 I 13.0 0.0 1.0 1.0 COG1183 Phosphatidylserine_synthase PssA 13.0 1.0 0.0 0.131350696425612 0.135699568534428 0.13352513248002 0.0043488721088159 0 0 0 0 K19666 0.0 0.0056980056980056 solR, cepR, tofR; LuxR family transcriptional regulator, quorum-sensing system regulator SolR path:map02020,path:map02024 Two-component system,Quorum sensing 127.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 2.0 0.0 1.0 0 0 0 0 K19668 0.0057142857142857 0.0541310541310541 CBH2, cbhA; cellulose 1,4-beta-cellobiosidase [EC:3.2.1.91] path:map00500,path:map01100,path:map02020 Starch and sucrose metabolism,Metabolic pathways,Two-component system 174.0 16.0 12.0 4.0 0.695652173913043 G 2.0 21.0 7.0 0.521739130434783 COG5297 Cellulase/cellobiase_CelA1 CelA1 23.0 0.0869565217391304 0.9130434782608696 0.0227281754084912 0.270377310927783 0.1465527431681371 0.2476491355192918 0 0 0 0 K19670 0.0028571428571428 0.0227920227920227 phnA; phosphonoacetate hydrolase [EC:3.11.1.2] path:map00440,path:map01100,path:map01120 Phosphonate and phosphinate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 361.0 9.0 0.0 1.0 1.0 S 1.0 8.0 1.0 1.0 COG1524 c-di-AMP_phosphodiesterase_AtaC_or_nucleotide_pyrophosphatase,_AlkP_superfamily AtaC 9.0 0.1111111111111111 0.8888888888888888 0.0462930976155458 0.108343507592125 0.0773183026038354 0.0620504099765791 0 0 0 0 K19673 0.0 0.0028490028490028 TTC21B, IFT139B; tetratricopeptide repeat protein 21B 137.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28HZH 1.0 0.0 1.0 0 0 0 0 K19676 0.0 0.0028490028490028 IFT172; intraflagellar transport protein 172 396.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG0210 Superfamily_I_DNA_or_RNA_helicase UvrD 1.0 0.0 1.0 0 0 0 0 K19681 0.0085714285714285 0.0 IFT52; intraflagellar transport protein 52 184.0 3.0 0.0 1.0 1.0 W 3.0 0.0 1.0 1.0 KOG3861 3.0 1.0 0.0 0 0 0 0 K19686 0.0028571428571428 0.0626780626780626 vapC; ribonuclease VapC [EC:3.1.-.-] 104.0 28.0 24.0 2.0 0.875 S 1.0 31.0 2.0 0.90625 COG3742 VapC_family_ribonuclease,_contains_PIN_domain VapC 32.0 0.03125 0.96875 0.0106318953368645 0.0221717451419558 0.0164018202394101 0.0115398498050913 0 0 0 0 K19687 0.0 0.0569800569800569 vapB; antitoxin VapB 55.0 29.0 28.0 2.0 0.966666666666667 S 0.0 33.0 3.0 0.878787878787879 COG4423 Uncharacterized_conserved_protein 33.0 0.0 1.0 0.0078084174528667 0.0176193426874412 0.0127138800701539 0.0098109252345745 0 0 0 0 K19688 0.0 0.0028490028490028 bssR; biofilm regulator BssR 127.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 29WPV 1.0 0.0 1.0 0 0 0 0 K19689 0.2971428571428571 0.282051282051282 ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-] 172.0 306.0 305.0 2.0 0.996742671009772 E 176.0 131.0 2.0 0.96742671009772 COG2309 Leucyl_aminopeptidase_(aminopeptidase_T) AmpS 307.0 0.5732899022801303 0.4267100977198697 0.0230817700651589 0.676406039620955 0.3497439048430569 0.6533242695557961 0 0 0 0 K19693 0.0 0.0427350427350427 tfoS; AraC family transcriptional regulator, chitin signaling transcriptional activator 140.0 5.0 3.0 4.0 0.5 T 0.0 16.0 3.0 0.8125 COG3292 Periplasmic_ligand-binding_sensor_domain 16.0 0.0 1.0 0.347621196333408 0.146185526122245 0.2469033612278265 0.201435670211163 0 0 0 0 K19694 0.0 0.0 chiS; two-component system, sensor histidine kinase ChiS 19.0 0.0 1.0 1.0 T 0.0 0.0 6.0 0.473684210526316 COG0642 Signal_transduction_histidine_kinase BaeS 0.0 0 0 0 0 K19696 0.0 0.0313390313390313 mtiP; 5'-methylthioinosine phosphorylase [EC:2.4.2.44] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 232.0 11.0 0.0 1.0 1.0 F 0.0 11.0 1.0 1.0 COG0005 Purine_nucleoside_phosphorylase XapA 11.0 0.0 1.0 0.0253540959935549 0.0392540234874026 0.0323040597404787 0.0138999274938477 0 0 0 0 K19700 0.0 0.0028490028490028 sap; 3-succinoylsemialdehyde-pyridine dehydrogenase [EC:1.2.1.83] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 476.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 1.0 0.0 1.0 0 0 0 0 K19701 0.04 0.037037037037037 ywaD; aminopeptidase YwaD [EC:3.4.11.6 3.4.11.10] 103.0 16.0 1.0 3.0 0.5 S 17.0 15.0 2.0 0.96875 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 32.0 0.53125 0.46875 0.100938888843836 0.0732443034439813 0.0870915961439086 0.0276945853998547 0 0 0 0 K19702 0.0342857142857142 0.0256410256410256 E3.4.11.24; aminopeptidase S [EC:3.4.11.24] 153.0 13.0 6.0 4.0 0.52 DZ 14.0 11.0 1.0 1.0 COG2234 Zn-dependent_amino-_or_carboxypeptidase,_M28_family Iap 25.0 0.56 0.44 0.875504229579675 0.67992148223132 0.7777128559054975 0.195582747348355 1 1 1 1 K19707 0.0 0.0569800569800569 rsbQ; sigma-B regulation protein RsbQ 175.0 13.0 6.0 3.0 0.619047619047619 S 0.0 21.0 3.0 0.666666666666667 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 21.0 0.0 1.0 0.0379166587062834 0.47302317919178 0.2554699189490317 0.4351065204854966 0 0 0 0 K19709 0.0 0.0085470085470085 ydiF; acetate CoA-transferase [EC:2.8.3.8] path:map00627,path:map00650,path:map01100,path:map01120 Aminobenzoate degradation,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 85.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG4670 Acyl_CoA:acetate/3-ketoacid_CoA_transferase YdiF 3.0 0.0 1.0 0 0 0 0 K19710 0.3771428571428571 0.3076923076923077 E2.7.7.53; ATP adenylyltransferase [EC:2.7.7.53] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 67.0 142.0 21.0 4.0 0.531835205992509 F 150.0 115.0 3.0 0.966292134831461 COG0537 Purine_nucleoside_phosphoramidase/Ap4A_hydrolase,_histidine_triade_(HIT)_family HinT 265.0 0.5660377358490566 0.4339622641509434 0.287282747920496 0.629727966777075 0.4585053573487855 0.3424452188565789 0 0 0 0 K19711 0.0 0.0056980056980056 E1.1.1.387; L-serine 3-dehydrogenase (NAD+) [EC:1.1.1.387] 288.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 2.0 0.0 1.0 0 0 0 0 K19712 0.4142857142857143 0.0 cobY; adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.7.62] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 112.0 80.0 9.0 2.0 0.529801324503311 M 151.0 0.0 1.0 1.0 COG2266 GTP:adenosylcobinamide-phosphate_guanylyltransferase 151.0 1.0 0.0 0.0059107716840818 0.0165978900516791 0.0112543308678804 0.0106871183675972 0 0 0 0 K19713 0.0028571428571428 0.0911680911680911 tsdA; thiosulfate dehydrogenase [EC:1.8.2.2] 144.0 44.0 42.0 2.0 0.956521739130435 C 2.0 44.0 4.0 0.804347826086957 COG3258 Thiosulfate_dehydrogenase_TsdA,_contains_C-terminal_cytochrome_c_domain TsdA 46.0 0.0434782608695652 0.9565217391304348 0.0188949426639908 0.0387700649299566 0.0288325037969736 0.0198751222659657 0 0 0 0 K19714 0.0 0.0484330484330484 kdnB; 3-deoxy-alpha-D-manno-octulosonate 8-oxidase [EC:1.1.3.48] 8.0 14.0 4.0 4.0 0.538461538461538 C 0.0 24.0 2.0 0.538461538461538 COG1454 Alcohol_dehydrogenase,_class_IV EutG 24.0 0.0 1.0 0.0074993114283283 0.0137744012937834 0.0106368563610558 0.0062750898654551 0 0 0 0 K19715 0.0085714285714285 0.0769230769230769 kdnA; 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase [EC:2.6.1.109] 314.0 34.0 0.0 1.0 1.0 E 3.0 31.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 34.0 0.088235294117647 0.9117647058823528 0.0454684383818776 0.0374951858728639 0.0414818121273707 0.0079732525090137 0 0 0 0 K19719 0.0 0.0085470085470085 COL2A; collagen type II alpha path:map04151,path:map04510,path:map04512,path:map04974,path:map05165 PI3K-Akt signaling pathway,Focal adhesion,ECM-receptor interaction,Protein digestion and absorption,Human papillomavirus infection 592.0 2.0 1.0 2.0 0.666666666666667 NU 0.0 3.0 2.0 0.666666666666667 COG3266 Cell_division_protein_DamX,_binds_to_the_septal_ring,_contains_C-terminal_SPOR_domain DamX 3.0 0.0 1.0 0 0 0 0 K19720 0.0 0.0085470085470085 COL3A; collagen type III alpha path:map04611,path:map04926,path:map04933,path:map04974,path:map05146,path:map05415 Platelet activation,Relaxin signaling pathway,AGE-RAGE signaling pathway in diabetic complications,Protein digestion and absorption,Amoebiasis,Diabetic cardiomyopathy 167.0 3.0 0.0 1.0 1.0 M 0.0 6.0 2.0 0.5 2AUYC 6.0 0.0 1.0 2.4223539889826097e-12 0.0574681372857769 0.0287340686440996 0.0574681372833545 0 0 0 0 K19731 0.0 0.017094017094017 cciR; LuxR family transcriptional regulator, quorum-sensing system regulator CciR path:map02024 Quorum sensing 198.0 6.0 5.0 2.0 0.857142857142857 K 0.0 7.0 2.0 0.571428571428571 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 7.0 0.0 1.0 0.0249080992875052 0.0520571383513716 0.0384826188194384 0.0271490390638664 0 0 0 0 K19732 0.0 0.0028490028490028 traR; LuxR family transcriptional regulator, activator of conjugal transfer of Ti plasmids path:map02024 Quorum sensing 233.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2771 DNA-binding_transcriptional_regulator,_CsgD_family CsgD 1.0 0.0 1.0 0 0 0 0 K19733 0.0 0.0256410256410256 sinR, avsR; LuxR family transcriptional regulator, quorum-sensing system regulator SinR path:map02024 Quorum sensing 208.0 11.0 0.0 1.0 1.0 K 0.0 11.0 2.0 0.818181818181818 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 11.0 0.0 1.0 0.0070079450757884 0.0154819718627553 0.0112449584692718 0.0084740267869669 0 0 0 0 K19734 0.0 0.0113960113960113 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR path:map02024 Quorum sensing 133.0 4.0 0.0 1.0 1.0 K 0.0 4.0 2.0 0.5 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 4.0 0.0 1.0 0.0640683156895628 0.136037352840989 0.1000528342652758 0.0719690371514262 0 0 0 0 K19736 0.0 0.037037037037037 aefR; TetR/AcrR family transcriptional regulator, regulator of autoinduction and epiphytic fitness 152.0 15.0 0.0 1.0 1.0 K 0.0 15.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 15.0 0.0 1.0 0.0049220331158904 0.0110230057756896 0.00797251944579 0.0061009726597992 0 0 0 0 K19742 0.0 0.0028490028490028 lhpI; 1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 312.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 2.0 0.0 1.0 0 0 0 0 K19743 0.0 0.0284900284900284 lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1] path:map00310,path:map00330,path:map00960,path:map01100 Lysine degradation,Arginine and proline metabolism,Tropane, piperidine and pyridine alkaloid biosynthesis,Metabolic pathways 278.0 12.0 0.0 1.0 1.0 E 0.0 12.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 12.0 0.0 1.0 0.0172904930931077 0.539284851871084 0.2782876724820958 0.5219943587779763 0 0 0 0 K19745 0.0 0.1396011396011396 acuI; acrylyl-CoA reductase (NADPH) [EC:1.3.1.-] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 299.0 50.0 0.0 1.0 1.0 C 0.0 50.0 1.0 1.0 COG0604 NADPH:quinone_reductase_or_related_Zn-dependent_oxidoreductase Qor 50.0 0.0 1.0 0.0435266747742911 0.14655837660052 0.0950425256874055 0.1030317018262289 0 0 0 0 K19746 0.0 0.0484330484330484 dauA; D-arginine dehydrogenase [EC:1.4.99.6] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 332.0 18.0 0.0 1.0 1.0 E 0.0 18.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 18.0 0.0 1.0 0.0250679480085767 0.0684214869693245 0.0467447174889506 0.0433535389607478 0 0 0 0 K19765 0.0 0.0028490028490028 HSBP1; heat shock factor-binding protein 1 path:map04212 Longevity regulating pathway - worm 694.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG1196 Chromosome_segregation_ATPase_Smc Smc 1.0 0.0 1.0 0 0 0 0 K19775 0.0 0.0056980056980056 exuR; GntR family transcriptional regulator, hexuronate regulon transcriptional repressor 218.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 2.0 0.0 1.0 0 0 0 0 K19776 0.0 0.0142450142450142 dgoR; GntR family transcriptional regulator, galactonate operon transcriptional repressor 234.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 5.0 0.0 1.0 0.0318664090323694 0.094506833906529 0.0631866214694492 0.0626404248741596 0 0 0 0 K19777 0.0 0.0085470085470085 hdeA; acid stress chaperone HdeA 88.0 1.0 0.0 1.0 1.0 M 0.0 6.0 3.0 0.5 2B0KE 6.0 0.0 1.0 0.0017731599837319 4.76331373309837e-09 0.0008865823735228 0.0017731552204181 0 0 0 0 K19778 0.0 0.0056980056980056 hdeB; acid stress chaperone HdeB 92.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 2EACP 2.0 0.0 1.0 0 0 0 0 K19780 0.0 0.0028490028490028 ralA, rcbA; antisense regulator of RalR protein 69.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 2FGCN 1.0 0.0 1.0 0 0 0 0 K19784 0.0485714285714285 0.1481481481481481 chrR, NQR; chromate reductase, NAD(P)H dehydrogenase (quinone) 130.0 77.0 72.0 2.0 0.939024390243902 S 18.0 64.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 82.0 0.2195121951219512 0.7804878048780488 0.0112776932992659 0.0520442407738146 0.0316609670365402 0.0407665474745487 0 0 0 0 K19785 0.0028571428571428 0.0142450142450142 POF1; nicotinamide-nucleotide adenylyltransferase [EC:2.7.7.1] path:map00760,path:map01100 Nicotinate and nicotinamide metabolism,Metabolic pathways 222.0 5.0 4.0 2.0 0.833333333333333 S 1.0 5.0 1.0 1.0 2A0BN 6.0 0.1666666666666666 0.8333333333333334 0.077193681241423 0.580219795481012 0.3287067383612175 0.503026114239589 0 0 0 0 K19787 0.0 0.0028490028490028 CARNMT1; carnosine N-methyltransferase [EC:2.1.1.22] path:map00340,path:map01100 Histidine metabolism,Metabolic pathways 462.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 KOG2798 1.0 0.0 1.0 0 0 0 0 K19789 0.0028571428571428 0.0398860398860398 radD; DNA repair protein RadD 108.0 21.0 20.0 2.0 0.954545454545455 L 1.0 21.0 2.0 0.954545454545455 COG1061 Superfamily_II_DNA_or_RNA_helicase SSL2 22.0 0.0454545454545454 0.9545454545454546 0.0292324892324712 0.0668735454057654 0.0480530173191183 0.0376410561732942 0 0 0 0 K19793 0.0285714285714285 0.0 mfnC; (5-formylfuran-3-yl)methyl phosphate transaminase [EC:2.6.1.108] path:map00680,path:map01100,path:map01240 Methane metabolism,Metabolic pathways,Biosynthesis of cofactors 376.0 10.0 0.0 1.0 1.0 E 10.0 0.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 10.0 1.0 0.0 0.0402429628017287 0.178452698571458 0.1093478306865933 0.1382097357697293 0 0 0 0 K19794 0.0 0.0199430199430199 bar; barbiturase [EC:3.5.2.1] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 368.0 6.0 5.0 2.0 0.857142857142857 S 0.0 7.0 1.0 1.0 2DBC4 7.0 0.0 1.0 0.0227912632223125 0.0463089621765835 0.034550112699448 0.023517698954271 0 0 0 0 K19795 0.0 0.0028490028490028 E3.5.1.95; ureidomalonase [EC:3.5.1.95] path:map00240,path:map01100 Pyrimidine metabolism,Metabolic pathways 466.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 1.0 0.0 1.0 0 0 0 0 K19802 0.18 0.3133903133903133 ycjG, ykfB; L-Ala-D/L-Glu epimerase [EC:5.1.1.20] 168.0 219.0 218.0 2.0 0.995454545454546 M 82.0 138.0 2.0 0.995454545454546 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 220.0 0.3727272727272727 0.6272727272727273 0.915019007192877 0.401786018264256 0.6584025127285664 0.513232988928621 1 1 1 1 K19803 0.0 0.0142450142450142 lpxT; Kdo2-lipid A phosphotransferase [EC:2.7.4.29] path:map00540 Lipopolysaccharide biosynthesis 236.0 4.0 3.0 2.0 0.8 I 0.0 5.0 1.0 1.0 COG0671 Membrane-associated_phospholipid_phosphatase PgpB 5.0 0.0 1.0 3.89713856599269e-07 4.39928915372008e-08 2.168533740682349e-07 3.457209650620682e-07 0 0 0 0 K19804 0.0 0.1481481481481481 lapB; lipopolysaccharide assembly protein B 109.0 56.0 0.0 1.0 1.0 G 0.0 56.0 2.0 0.982142857142857 COG2956 Lipopolysaccharide_biosynthesis_regulator_YciM/LapB,_contains_six_TPR_domains_and_a_C-terminal_metal-binding_domain LapB 56.0 0.0 1.0 0.0128884248378929 0.0508104953603128 0.0318494600991028 0.0379220705224199 0 0 0 0 K19809 0.0 0.0113960113960113 RIR; 2-methyl-1-pyrroline reductase [EC:1.5.1.48] 113.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG2084 3-hydroxyisobutyrate_dehydrogenase_or_related_beta-hydroxyacid_dehydrogenase MmsB 4.0 0.0 1.0 4.22623886078659e-05 0.0168180436932782 0.008430153040943 0.0167757813046703 0 0 0 0 K19810 0.0 0.0512820512820512 epmB; L-lysine 2,3-aminomutase [EC:5.4.3.-] 307.0 12.0 6.0 2.0 0.666666666666667 C 0.0 18.0 1.0 1.0 COG1509 L-lysine_2,3-aminomutase_(EF-P_beta-lysylation_pathway) EpmB 18.0 0.0 1.0 0.0119100378866636 0.016464567926187 0.0141873029064253 0.0045545300395234 0 0 0 0 K19811 0.0 0.0028490028490028 hsdA; 3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.357] 257.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K19813 0.0 0.0199430199430199 gdh; glucose dehydrogenase [EC:1.1.5.9] path:map00030,path:map01100,path:map01110 Pentose phosphate pathway,Metabolic pathways,Biosynthesis of secondary metabolites 497.0 8.0 7.0 2.0 0.888888888888889 E 0.0 9.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 9.0 0.0 1.0 0.0295405175375608 0.0918209884775946 0.0606807530075777 0.0622804709400337 0 0 0 0 K19814 0.0057142857142857 0.0199430199430199 eam; glutamate 2,3-aminomutase [EC:5.4.3.9] 362.0 8.0 7.0 2.0 0.888888888888889 E 2.0 7.0 1.0 1.0 COG1509 L-lysine_2,3-aminomutase_(EF-P_beta-lysylation_pathway) EpmB 9.0 0.2222222222222222 0.7777777777777778 0.0177616687132087 0.0830744017665869 0.0504180352398977 0.0653127330533782 0 0 0 0 K19817 0.0457142857142857 0.0 fprA; coenzyme F420H2 oxidase [EC:1.5.3.22] 405.0 19.0 0.0 1.0 1.0 C 19.0 0.0 1.0 1.0 COG0426 Flavorubredoxin NorV 19.0 1.0 0.0 0.0057869956921568 0.0087620381555108 0.0072745169238338 0.002975042463354 0 0 0 0 K19819 0.0028571428571428 0.0142450142450142 ndhB; nicotine dehydrogenase subunit B [EC:1.5.99.4] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 153.0 6.0 0.0 1.0 1.0 C 1.0 5.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 6.0 0.1666666666666666 0.8333333333333334 0.462741328503811 0.265011567554316 0.3638764480290635 0.197729760949495 0 0 0 0 K19820 0.0028571428571428 0.0085470085470085 ndhC; nicotine dehydrogenase subunit C [EC:1.5.99.4] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 748.0 7.0 0.0 1.0 1.0 C 1.0 6.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 7.0 0.1428571428571428 0.8571428571428571 0.0261563815704711 0.0421454198233553 0.0341509006969132 0.0159890382528841 0 0 0 0 K19824 0.0828571428571428 0.017094017094017 fprB; rubrerythrin 115.0 37.0 0.0 1.0 1.0 C 31.0 6.0 1.0 1.0 COG1592 Rubrerythrin YotD 37.0 0.8378378378378378 0.1621621621621621 0.92657270287896 0.959486924406059 0.9430298136425096 0.032914221527099 1 1 1 1 K19837 0.0 0.0284900284900284 atzE; 1-carboxybiuret hydrolase [EC:3.5.1.131] path:map00791,path:map01100,path:map01120 Atrazine degradation,Metabolic pathways,Microbial metabolism in diverse environments 446.0 10.0 0.0 1.0 1.0 J 0.0 10.0 1.0 1.0 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 10.0 0.0 1.0 0.351417631135381 0.404572517058031 0.3779950740967059 0.05315488592265 0 0 0 0 K19856 0.0 0.0085470085470085 aveBVII, avrH; 3-O-methyltransferase [EC:2.1.1.-] path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 124.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 2.0 0.666666666666667 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 3.0 0.0 1.0 0 0 0 0 K19857 0.0028571428571428 0.0113960113960113 aveBIV, avrE; dTDP-4-keto-6-deoxy-L-hexose 4-reductase path:map00523,path:map01100,path:map01110,path:map01250 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of nucleotide sugars 315.0 4.0 2.0 2.0 0.666666666666667 M 1.0 5.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 6.0 0.1666666666666666 0.8333333333333334 6.04308951166309e-12 0.0736885210422326 0.0368442605241378 0.0736885210361895 0 0 0 0 K19872 0.0 0.0056980056980056 FKTN; fukutin [EC:2.7.8.-] path:map00515,path:map01100 Mannose type O-glycan biosynthesis,Metabolic pathways 291.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG3475 Phosphorylcholine_metabolism_protein_LicD LicD 2.0 0.0 1.0 0 0 0 0 K19873 0.0 0.0056980056980056 FKRP; fukutin-related protein [EC:2.7.8.-] path:map00515,path:map01100 Mannose type O-glycan biosynthesis,Metabolic pathways 291.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 28NJB 2.0 0.0 1.0 0 0 0 0 K19874 0.0 0.0028490028490028 SEPN1; selenoprotein N 239.0 9.0 8.0 2.0 0.9 S 0.0 10.0 1.0 1.0 28J2D 10.0 0.0 1.0 2.19377138446787e-22 1.88241816418852e-18 9.413187706634836e-19 1.882198787050073e-18 0 0 0 0 K19882 0.0 0.0028490028490028 NOTUM; O-palmitoleoyl-L-serine hydrolase [EC:3.1.1.98] path:map04310 Wnt signaling pathway 548.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 KOG4287 1.0 0.0 1.0 0 0 0 0 K19883 0.0 0.0085470085470085 aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase [EC:2.3.1.82 2.7.1.190] 184.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3173 Predicted__kinase,_aminoglycoside_phosphotransferase_(APT)_family YcbJ 3.0 0.0 1.0 0 0 0 0 K19954 0.0514285714285714 0.0968660968660968 adh1; alcohol dehydrogenase [EC:1.1.1.-] 241.0 56.0 0.0 1.0 1.0 C 20.0 36.0 1.0 1.0 COG1454 Alcohol_dehydrogenase,_class_IV EutG 56.0 0.3571428571428571 0.6428571428571429 0.380111776488208 0.728534515098035 0.5543231457931215 0.348422738609827 0 0 0 0 K19955 0.0057142857142857 0.1225071225071225 adh2; alcohol dehydrogenase [EC:1.1.1.-] 335.0 51.0 0.0 1.0 1.0 C 2.0 49.0 1.0 1.0 COG1979 Alcohol_dehydrogenase_YqhD,_Fe-dependent_ADH_family YqdH 51.0 0.0392156862745098 0.9607843137254902 0.861258982895387 0.802381807506557 0.831820395200972 0.05887717538883 0 0 1 1 K19956 0.0 0.0484330484330484 sorE; L-sorbose 1-phosphate reductase [EC:1.1.1.-] path:map00051,path:map01100 Fructose and mannose metabolism,Metabolic pathways 405.0 16.0 15.0 2.0 0.941176470588235 E 0.0 17.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 17.0 0.0 1.0 0.864085933843501 0.377124727583431 0.620605330713466 0.4869612062600699 0 0 1 1 K19961 0.0 0.0056980056980056 chnD; 6-hydroxyhexanoate dehydrogenase [EC:1.1.1.258] path:map00930,path:map01220 Caprolactam degradation,Degradation of aromatic compounds 349.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 2.0 0.0 1.0 0 0 0 0 K19965 0.0085714285714285 0.0227920227920227 folQ; dihydroneopterin triphosphate pyrophosphohydrolase [EC:3.6.1.67] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 119.0 11.0 0.0 1.0 1.0 F 3.0 8.0 1.0 1.0 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 11.0 0.2727272727272727 0.7272727272727273 0.131593790988543 0.250266854242039 0.190930322615291 0.1186730632534959 0 0 0 0 K19966 0.0 0.0113960113960113 acdDPN7; 3-sulfinopropanoyl-CoA desulfinase [EC:3.13.1.4] 368.0 2.0 0.0 2.0 0.5 C 0.0 4.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 4.0 0.0 1.0 0.158901583643562 0.244126753067851 0.2015141683557065 0.085225169424289 0 0 0 0 K19967 0.0 0.0113960113960113 dta; D-threonine aldolase [EC:4.1.2.42] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 352.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG3616 D-serine_deaminase,_pyridoxal_phosphate-dependent Dsd1 4.0 0.0 1.0 0.0154894818513898 0.039123590790932 0.0273065363211609 0.0236341089395422 0 0 0 0 K19969 0.0 0.0398860398860398 acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase [EC:4.2.3.152] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 342.0 13.0 12.0 2.0 0.928571428571429 E 0.0 15.0 1.0 1.0 COG0337 3-dehydroquinate_synthetase AroB 15.0 0.0 1.0 0.0185645693961473 0.0798570147635727 0.04921079207986 0.0612924453674254 0 0 0 0 K19971 0.0 0.0113960113960113 psaA, scaA, sloC; manganese/zinc transport system substrate-binding protein path:map02010 ABC transporters 303.0 5.0 0.0 1.0 1.0 P 0.0 5.0 1.0 1.0 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 5.0 0.0 1.0 7.68608553319061e-08 2.87660042138458e-05 1.4421432534588852e-05 2.8689143358513892e-05 0 0 0 0 K19972 0.0 0.0056980056980056 psaC, scaB, sloB; manganese/zinc transport system permease protein path:map02010 ABC transporters 282.0 2.0 0.0 1.0 1.0 P 0.0 2.0 1.0 1.0 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 2.0 0.0 1.0 0 0 0 0 K19973 0.0114285714285714 0.0769230769230769 mntA; manganese transport system ATP-binding protein [EC:7.2.2.5] path:map02010 ABC transporters 226.0 34.0 0.0 1.0 1.0 P 4.0 30.0 1.0 1.0 COG1121 ABC-type_Mn2+/Zn2+_transport_system,_ATPase_component ZnuC 34.0 0.1176470588235294 0.8823529411764706 0.0341886572877484 0.13444889340294 0.0843187753453442 0.1002602361151916 0 0 0 0 K19974 0.0 0.0113960113960113 acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 220.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 4.0 0.0 1.0 0.103025379932704 0.201370694340223 0.1521980371364635 0.098345314407519 0 0 0 0 K19975 0.0085714285714285 0.0398860398860398 mntC; manganese transport system substrate-binding protein path:map02010 ABC transporters 195.0 19.0 0.0 1.0 1.0 P 3.0 16.0 2.0 0.736842105263158 COG0803 ABC-type_Zn_uptake_system_ZnuABC,_Zn-binding_component_ZnuA ZnuA 19.0 0.1578947368421052 0.8421052631578947 0.0422044837191859 0.325698680818724 0.1839515822689549 0.2834941970995381 0 0 0 0 K19976 0.0171428571428571 0.0854700854700854 mntB; manganese transport system permease protein path:map02010 ABC transporters 229.0 48.0 46.0 3.0 0.941176470588235 P 6.0 45.0 2.0 0.862745098039216 COG1108 ABC-type_Mn2+/Zn2+_transport_system,_permease_component ZnuB 51.0 0.1176470588235294 0.8823529411764706 0.168140079403797 0.391542561543596 0.2798413204736965 0.223402482139799 0 0 0 0 K19978 0.0028571428571428 0.0142450142450142 acbK; acarbose 7IV-phosphotransferase [EC:2.7.1.187] path:map00525,path:map01110 Acarbose and validamycin biosynthesis,Biosynthesis of secondary metabolites 268.0 6.0 0.0 1.0 1.0 G 1.0 5.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 6.0 0.1666666666666666 0.8333333333333334 0.054383556130421 0.109082812917393 0.081733184523907 0.0546992567869719 0 0 0 0 K19979 0.0 0.0313390313390313 acbM; 2-epi-5-epi-valiolone 7-kinase [EC:2.7.1.188] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 232.0 11.0 10.0 2.0 0.916666666666667 GK 0.0 12.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 12.0 0.0 1.0 0.052320403129729 0.13266113681169 0.0924907699707095 0.080340733681961 0 0 0 0 K19982 0.0 0.0512820512820512 prnD; aminopyrrolnitrin oxygenase [EC:1.14.13.-] path:map00404,path:map01100,path:map01110 Staurosporine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 184.0 22.0 0.0 1.0 1.0 P 0.0 22.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 22.0 0.0 1.0 0.0115423705796139 0.0285370676706317 0.0200397191251228 0.0169946970910178 0 0 0 0 K19997 0.0114285714285714 0.0598290598290598 gnu; GlcNAc-P-P-Und epimerase [EC:5.1.3.26] 152.0 14.0 1.0 2.0 0.518518518518518 GM 4.0 23.0 2.0 0.925925925925926 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 27.0 0.1481481481481481 0.8518518518518519 0.0817444698932298 0.506830053672308 0.2942872617827689 0.4250855837790782 0 0 0 0 K20011 0.0028571428571428 0.0313390313390313 PRDX3; peroxiredoxin 3 [EC:1.11.1.24 1.11.1.25] 187.0 12.0 0.0 1.0 1.0 O 1.0 11.0 1.0 1.0 COG0450 Alkyl_hydroperoxide_reductase_subunit_AhpC_(peroxiredoxin) AhpC 12.0 0.0833333333333333 0.9166666666666666 0.152083038310343 0.850243877942992 0.5011634581266675 0.6981608396326491 0 0 0 0 K20021 0.0114285714285714 0.0028490028490028 E4.4.1.28; L-cysteine desulfidase [EC:4.4.1.28] path:map00270,path:map01100 Cysteine and methionine metabolism,Metabolic pathways 379.0 5.0 0.0 1.0 1.0 E 4.0 1.0 1.0 1.0 COG3681 L-cysteine_desulfidase_YhaM CdsB 5.0 0.8 0.2 0.0482520346544557 0.113093455279246 0.0806727449668508 0.0648414206247903 0 0 0 0 K20022 0.0 0.0056980056980056 galrD-II; galactarate dehydratase (D-threo-forming) [EC:4.2.1.158] 340.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 4.0 0.0 1.0 1.85272713281472e-12 3.2314506730452897e-12 2.542088902930005e-12 1.3787235402305697e-12 0 0 0 0 K20023 0.0 0.0683760683760683 talrD-galrD; L-talarate/galactarate dehydratase [EC:4.2.1.156 4.2.1.42] path:map00053,path:map01100 Ascorbate and aldarate metabolism,Metabolic pathways 250.0 34.0 0.0 1.0 1.0 M 0.0 34.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 34.0 0.0 1.0 0.0148482279265694 0.029810434302034 0.0223293311143017 0.0149622063754645 0 0 0 0 K20024 0.0 0.0313390313390313 mgdE; monoglucosyldiacylglycerol epimerase [EC:5.1.3.34] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 390.0 10.0 9.0 2.0 0.909090909090909 I 0.0 11.0 2.0 0.909090909090909 COG0300 Short-chain_dehydrogenase YqjQ 11.0 0.0 1.0 0.000384470926174 0.0016800490748002 0.0010322600004871 0.0012955781486262 0 0 0 0 K20025 0.0 0.0028490028490028 hadB; (R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit [EC:4.2.1.157] 422.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 2.0 0.0 1.0 0 0 0 0 K20034 0.0028571428571428 0.074074074074074 dmdB; 3-(methylthio)propionyl---CoA ligase [EC:6.2.1.44] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 475.0 31.0 0.0 1.0 1.0 IQ 1.0 30.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 31.0 0.032258064516129 0.967741935483871 0.0027916781703442 0.0106206017681312 0.0067061399692376 0.007828923597787 0 0 0 0 K20035 0.0028571428571428 0.1025641025641025 dmdC; 3-(methylsulfanyl)propanoyl-CoA dehydrogenase [EC:1.3.99.41] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 489.0 24.0 7.0 2.0 0.585365853658537 I 1.0 40.0 2.0 0.975609756097561 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 41.0 0.024390243902439 0.975609756097561 0.0034975615613305 0.0628829671179731 0.0331902643396518 0.0593854055566426 0 0 0 0 K20036 0.0 0.0313390313390313 dmdD; (methylthio)acryloyl-CoA hydratase [EC:4.2.1.155] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 251.0 13.0 0.0 1.0 1.0 I 0.0 13.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 13.0 0.0 1.0 0.0114162522651423 0.0537584595944108 0.0325873559297765 0.0423422073292685 0 0 0 0 K20037 0.0 0.0142450142450142 cutD; choline trimethylamine-lyase activating enzyme [EC:1.97.1.-] 298.0 4.0 3.0 2.0 0.8 C 0.0 5.0 1.0 1.0 COG1180 Pyruvate-formate_lyase-activating_enzyme PflA 5.0 0.0 1.0 0.104702107819905 0.192645465002086 0.1486737864109955 0.087943357182181 0 0 0 0 K20038 0.0371428571428571 0.0712250712250712 cutC; choline trimethylamine-lyase [EC:4.3.99.4] 581.0 66.0 0.0 1.0 1.0 C 19.0 47.0 1.0 1.0 COG1882 Pyruvate-formate_lyase PflD 66.0 0.2878787878787879 0.7121212121212122 0.0838115637780033 0.0774423408006888 0.080626952289346 0.0063692229773145 0 0 0 0 K20073 0.0 0.0028490028490028 mapZ, locZ; mid-cell-anchored protein Z 620.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 2DB6P 1.0 0.0 1.0 0 0 0 0 K20074 0.1228571428571428 0.5156695156695157 prpC, phpP; PPM family protein phosphatase [EC:3.1.3.16] 30.0 356.0 346.0 6.0 0.954423592493298 T 56.0 317.0 5.0 0.932975871313673 COG0631 Serine/threonine_protein_phosphatase_PrpC PTC1 373.0 0.1501340482573726 0.8498659517426274 0.0155364740274099 0.383439641205393 0.1994880576164014 0.3679031671779831 0 0 0 0 K20087 0.0 0.0056980056980056 vioB; violacein biosynthesis protein VioB path:map00404,path:map01100,path:map01110,path:map02024 Staurosporine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 179.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG1633 Rubrerythrin,_includes_spore_coat_protein_YhjR YhjR 2.0 0.0 1.0 0 0 0 0 K20090 0.0 0.0056980056980056 vioC; violacein synthase [EC:1.14.13.224] path:map00404,path:map01100,path:map01110,path:map02024 Staurosporine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 344.0 2.0 0.0 1.0 1.0 CH 0.0 2.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 2.0 0.0 1.0 0 0 0 0 K20099 0.0028571428571428 0.0 YTHDC2; ATP-dependent RNA helicase YTHDC2 [EC:3.6.4.13] 70.0 1.0 0.0 1.0 1.0 J 1.0 0.0 1.0 1.0 COG1383 Ribosomal_protein_S17E RPS17A 1.0 1.0 0.0 0 0 0 0 K20107 0.0 0.0284900284900284 109.0 14.0 0.0 1.0 1.0 G 0.0 14.0 3.0 0.5 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 14.0 0.0 1.0 0.0085479847426206 0.0347368056225218 0.0216423951825712 0.0261888208799012 0 0 0 0 K20108 0.0 0.0284900284900284 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] path:map00500,path:map02060 Starch and sucrose metabolism,Phosphotransferase system (PTS) 109.0 14.0 0.0 1.0 1.0 G 0.0 14.0 3.0 0.5 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 14.0 0.0 1.0 0.008058752022388 0.0355984311721703 0.0218285915972791 0.0275396791497823 0 0 0 0 K20110 0.0885714285714285 0.0 JAMM1; desampylase [EC:3.4.19.15] 125.0 31.0 0.0 1.0 1.0 S 31.0 0.0 1.0 1.0 COG1310 Proteasome_lid_subunit_RPN8/RPN11,_contains_Jab1/MPN_domain_metalloenzyme_(JAMM)_motif Rri1 31.0 1.0 0.0 0.0052211661206008 0.007951163516584 0.0065861648185924 0.0027299973959832 0 0 0 0 K20112 0.0 0.0028490028490028 gatA; galactose PTS system EIIA component [EC:2.7.1.204] path:map02060 Phosphotransferase system (PTS) 161.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1762 Phosphotransferase_system_mannitol/fructose-specific_IIA_domain_(Ntr-type) PtsN 1.0 0.0 1.0 0 0 0 0 K20113 0.0 0.0028490028490028 gatB; galactose PTS system EIIB component [EC:2.7.1.204] path:map02060 Phosphotransferase system (PTS) 100.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG3414 Phosphotransferase_system,_galactitol-specific_IIB_component SgaB 1.0 0.0 1.0 0 0 0 0 K20114 0.0 0.0056980056980056 gatC; galactose PTS system EIIC component path:map02060 Phosphotransferase system (PTS) 448.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG3775 Phosphotransferase_system,_galactitol-specific_IIC_component SgcC 2.0 0.0 1.0 0 0 0 0 K20116 0.0 0.0 53.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.735849056603774 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K20117 0.0 0.0 55.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.745454545454546 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K20118 0.0 0.0 ptsG, glcA, glcB; glucose PTS system EIICBA or EIICB component [EC:2.7.1.199] path:map00010,path:map00520,path:map01100,path:map02060 Glycolysis / Gluconeogenesis,Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Phosphotransferase system (PTS) 55.0 0.0 1.0 1.0 G 0.0 0.0 3.0 0.745454545454546 COG1263 Phosphotransferase_system_IIC_components,_glucose/maltose/N-acetylglucosamine-specific PtsG1 0.0 0 0 0 0 K20129 0.0 0.0028490028490028 ANKFY1; rabankyrin-5 490.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K20131 0.0028571428571428 0.0 RABGEF1; Rab5 GDP/GTP exchange factor 348.0 1.0 0.0 1.0 1.0 GM 1.0 0.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 1.0 1.0 0.0 0 0 0 0 K20138 0.0 0.0056980056980056 P40; flavastacin [EC:3.4.24.76] 339.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3979 Chitodextrinase 2.0 0.0 1.0 0 0 0 0 K20140 0.0 0.0256410256410256 cfiA; 2-oxoglutarate carboxylase large subunit [EC:6.4.1.7] 19.0 5.0 3.0 3.0 0.555555555555556 C 0.0 9.0 2.0 0.888888888888889 COG0511 Biotin_carboxyl_carrier_protein AccB 9.0 0.0 1.0 0.258722655988529 0.251457633552365 0.255090144770447 0.007265022436164 0 0 0 0 K20141 0.0 0.0056980056980056 cfiB; 2-oxoglutarate carboxylase small subunit [EC:6.4.1.7] 472.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG0439 Biotin_carboxylase AccC 2.0 0.0 1.0 0 0 0 0 K20148 0.0057142857142857 0.0028490028490028 dke1; acetylacetone-cleaving enzyme [EC:1.13.11.50] 89.0 2.0 1.0 2.0 0.666666666666667 L 2.0 1.0 2.0 0.666666666666667 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K20151 0.0 0.0056980056980056 fucT; alpha(1,3/1,4) fucosyltransferase [EC:2.4.1.65 2.4.1.152] 15.0 3.0 0.0 1.0 1.0 H 0.0 3.0 1.0 1.0 28IN0 3.0 0.0 1.0 0 0 0 0 K20157 0.0 0.0056980056980056 mppO; enduracididine beta-hydroxylase [EC:1.14.11.40] 341.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 2.0 0.0 1.0 0 0 0 0 K20170 0.0 0.0028490028490028 nicA1; nicotine oxidoreductase [EC:1.5.3.-] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 381.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG3344 Retron-type_reverse_transcriptase YkfC 1.0 0.0 1.0 0 0 0 0 K20171 0.0 0.0085470085470085 spmA; 3-succinoylpyridine monooxygenase subunit A path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 418.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 3.0 0.0 1.0 0 0 0 0 K20172 0.0 0.0056980056980056 spmC; 3-succinoylpyridine monooxygenase subunit C path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 151.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 2.0 0.0 1.0 0 0 0 0 K20200 0.0 0.0056980056980056 pchC; 4-cresol dehydrogenase (hydroxylating) cytochrome subunit path:map00623,path:map01120 Toluene degradation,Microbial metabolism in diverse environments 103.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 2.0 0.0 1.0 0 0 0 0 K20201 0.0457142857142857 0.1225071225071225 ywlE; protein arginine phosphatase [EC:3.9.1.2] 69.0 59.0 53.0 2.0 0.907692307692308 T 22.0 43.0 2.0 0.892307692307692 COG0394 Protein-tyrosine-phosphatase Wzb 65.0 0.3384615384615385 0.6615384615384615 0.0163868123600544 0.0520477598276928 0.0342172860938736 0.0356609474676384 0 0 0 0 K20202 0.0485714285714285 0.0 sudA; sulfide dehydrogenase subunit alpha [EC:1.8.1.19] 437.0 17.0 14.0 2.0 0.85 C 20.0 0.0 1.0 1.0 COG0493 NADPH-dependent_glutamate_synthase_beta_chain_or_related_oxidoreductase GltD 20.0 1.0 0.0 0.0182714569606446 0.025720632701882 0.0219960448312633 0.0074491757412374 0 0 0 0 K20203 0.0485714285714285 0.0056980056980056 sudB; sulfide dehydrogenase subunit beta [EC:1.8.1.19] 172.0 19.0 0.0 1.0 1.0 C 17.0 2.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 19.0 0.8947368421052632 0.1052631578947368 0.873974457901721 0.964000230269173 0.918987344085447 0.090025772367452 0 0 1 1 K20204 0.0 0.0028490028490028 griF; grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4] path:map00380,path:map00997,path:map01100,path:map01110 Tryptophan metabolism,Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 140.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG2304 Secreted_protein_containing_bacterial_Ig-like_domain_and_vWFA_domain YfbK 1.0 0.0 1.0 0 0 0 0 K20207 0.0 0.0227920227920227 gpx; hydroperoxy fatty acid reductase [EC:1.11.1.22] 153.0 8.0 7.0 2.0 0.888888888888889 O 0.0 9.0 1.0 1.0 COG0386 Thioredoxin/glutathione_peroxidase_BtuE,_reduces_lipid_peroxides BtuE 9.0 0.0 1.0 0.0564839570031049 0.0998296747712567 0.0781568158871808 0.0433457177681518 0 0 0 0 K20215 0.7142857142857143 0.0 dph5; diphthine synthase [EC:2.1.1.98] 159.0 193.0 136.0 3.0 0.720149253731343 J 268.0 0.0 2.0 0.932835820895522 COG1798 Diphthamide_biosynthesis_methyltransferase DPH5 268.0 1.0 0.0 0.782076265082718 0.895534779187715 0.8388055221352164 0.1134585141049969 0 0 1 1 K20218 0.0 0.017094017094017 hipH; 4-hydroxyisophthalate hydroxylase path:map00623,path:map01120 Toluene degradation,Microbial metabolism in diverse environments 456.0 5.0 4.0 2.0 0.833333333333333 CH 0.0 6.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 6.0 0.0 1.0 0.143195513366948 0.268652939975251 0.2059242266710995 0.125457426608303 0 0 0 0 K20219 0.0 0.0028490028490028 phsA; o-aminophenol oxidase [EC:1.10.3.4] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 672.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 1.0 0.0 1.0 0 0 0 0 K20238 0.0114285714285714 0.0227920227920227 E2.1.1.317; sphingolipid C9-methyltransferase [EC:2.1.1.317] 345.0 13.0 0.0 1.0 1.0 M 4.0 9.0 1.0 1.0 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 13.0 0.3076923076923077 0.6923076923076923 0.0321667553639693 0.0572177009349103 0.0446922281494397 0.025050945570941 0 0 0 0 K20241 0.0057142857142857 0.0 WDR44, RAB11BP; WD repeat-containing protein 44 57.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG1997 Ribosomal_protein_L37AE/L43A RPL43A 2.0 1.0 0.0 0 0 0 0 K20249 0.0 0.0113960113960113 raiI; acyl homoserine lactone synthase [EC:2.3.1.184] path:map00270,path:map01100,path:map02024 Cysteine and methionine metabolism,Metabolic pathways,Quorum sensing 211.0 4.0 0.0 1.0 1.0 H 0.0 4.0 1.0 1.0 COG3916 N-acyl-homoserine_lactone_synthase_LasI_(autoinducer_biosynthesis) LasI 4.0 0.0 1.0 2.16648315778427e-21 4.917514285040879e-13 2.458757153352856e-13 4.917514263376048e-13 0 0 0 0 K20250 0.0 0.0028490028490028 cciI; acyl homoserine lactone synthase [EC:2.3.1.184] path:map00270,path:map01100,path:map02024 Cysteine and methionine metabolism,Metabolic pathways,Quorum sensing 207.0 1.0 0.0 1.0 1.0 QT 0.0 1.0 1.0 1.0 COG3916 N-acyl-homoserine_lactone_synthase_LasI_(autoinducer_biosynthesis) LasI 1.0 0.0 1.0 0 0 0 0 K20252 0.0 0.0028490028490028 cinR; LuxR family transcriptional regulator, quorum-sensing system regulator CinR path:map02024 Quorum sensing 244.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2771 DNA-binding_transcriptional_regulator,_CsgD_family CsgD 1.0 0.0 1.0 0 0 0 0 K20256 0.0 0.0142450142450142 luxG; flavin reductase [EC:1.-.-.-] path:map02024 Quorum sensing 231.0 4.0 3.0 2.0 0.8 C 0.0 5.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 5.0 0.0 1.0 7.24446103281299e-12 3.49219463568507e-08 1.7464595408941758e-08 3.4914701895817895e-08 0 0 0 0 K20257 0.0 0.0 pqsE; 2-aminobenzoylacetyl-CoA thioesterase [EC:3.1.2.32] path:map00405,path:map01110,path:map02024,path:map02025 Phenazine biosynthesis,Biosynthesis of secondary metabolites,Quorum sensing,Biofilm formation - Pseudomonas aeruginosa 4.0 0.0 1.0 1.0 S 0.0 0.0 1.0 1.0 COG0491 Glyoxylase_or_a_related_metal-dependent_hydrolase,_beta-lactamase_superfamily_II GloB 0.0 0 0 0 0 K20261 0.0 0.0142450142450142 phzD; trans-2,3-dihydro-3-hydroxyanthranilic acid synthase [EC:3.3.2.15] path:map00405,path:map01100,path:map01110,path:map02024 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 203.0 6.0 0.0 1.0 1.0 Q 0.0 6.0 1.0 1.0 COG1535 Isochorismate_hydrolase EntB1 6.0 0.0 1.0 0.0041459119544684 0.013168469041289 0.0086571904978787 0.0090225570868206 0 0 0 0 K20262 0.0 0.0028490028490028 phzG; dihydrophenazinedicarboxylate synthase [EC:1.10.3.16] path:map00405,path:map01100,path:map01110,path:map02024 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Quorum sensing 209.0 1.0 0.0 1.0 1.0 H 0.0 1.0 1.0 1.0 COG0259 Pyridoxine/pyridoxamine_5'-phosphate_oxidase PdxH 1.0 0.0 1.0 0 0 0 0 K20263 0.0 0.017094017094017 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 390.0 6.0 0.0 1.0 1.0 T 0.0 6.0 3.0 0.5 COG3851 Signal_transduction_histidine_kinase_UhpB,_glucose-6-phosphate_specific UhpB 6.0 0.0 1.0 0.0197873255026186 0.0812742079045781 0.0505307667035983 0.0614868824019594 0 0 0 0 K20264 0.0 0.0142450142450142 fusR; two-component system, NarL family, response regulator FusR path:map02020,path:map02024 Two-component system,Quorum sensing 188.0 5.0 4.0 2.0 0.833333333333333 K 0.0 6.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 6.0 0.0 1.0 0.0158360616402097 0.0358280894860187 0.0258320755631141 0.0199920278458089 0 0 0 0 K20265 0.0685714285714285 0.0826210826210826 gadC; glutamate:GABA antiporter path:map02024 Quorum sensing 322.0 72.0 0.0 1.0 1.0 E 32.0 40.0 1.0 1.0 COG0531 Serine_transporter_YbeC,_amino_acid:H+_symporter_family PotE 72.0 0.4444444444444444 0.5555555555555556 0.0308587325669307 0.0427576675533091 0.0368082000601199 0.0118989349863783 0 0 0 0 K20266 0.0 0.0427350427350427 trbJ; type IV secretion system protein TrbJ path:map02024 Quorum sensing 210.0 34.0 0.0 1.0 1.0 U 0.0 34.0 1.0 1.0 COG5314 Conjugal_transfer/entry_exclusion_protein 34.0 0.0 1.0 0.0171931978085677 0.0425875129129867 0.0298903553607772 0.025394315104419 0 0 0 0 K20268 0.0 0.0056980056980056 rhiA; rhizosphere induced protein path:map02024 Quorum sensing 198.0 0.0 2.0 1.0 1.0 2B632 2.0 0.0 1.0 0 0 0 0 K20271 0.0 0.0056980056980056 accR; DeoR family transcriptional regulator, repressor of opine catabolism and conjugal transfer path:map02024 Quorum sensing 264.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 2.0 0.0 1.0 0 0 0 0 K20273 0.0 0.0056980056980056 zmpA; zinc metalloprotease ZmpA path:map02024 Quorum sensing 466.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG3227 Zn-dependent_metalloprotease_(Neutral_protease_B) LasB 4.0 0.0 1.0 2.03425144435003e-12 0.0316112370565502 0.0158056185292922 0.0316112370545159 0 0 0 0 K20274 0.0 0.0256410256410256 zmpB; zinc metalloprotease ZmpB path:map02024 Quorum sensing 171.0 5.0 1.0 5.0 0.384615384615385 S 0.0 13.0 6.0 0.384615384615385 COG1520 Outer_membrane_protein_assembly_factor_BamB,_contains_PQQ-like_beta-propeller_repeat PQQ 13.0 0.0 1.0 0.0166680069982149 0.0298542228562462 0.0232611149272305 0.0131862158580313 0 0 0 0 K20276 0.0 0.0 bapA; large repetitive protein path:map02024 Quorum sensing 104.0 1.0 24.0 0.224622030237581 S 0.0 0.0 75.0 0.107822410147992 COG1404 Serine_protease,_subtilisin_family AprE 0.0 0 0 0 0 K20277 0.0 0.0028490028490028 bcl; mannose-binding lectin path:map02024 Quorum sensing 117.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DNI1 1.0 0.0 1.0 0 0 0 0 K20280 0.0057142857142857 0.0 TRAPPC5, TRS31; trafficking protein particle complex subunit 5 404.0 2.0 0.0 1.0 1.0 J 2.0 0.0 1.0 1.0 COG0621 tRNA_A37_methylthiotransferase_MiaB MiaB 2.0 1.0 0.0 0 0 0 0 K20302 0.0057142857142857 0.0 TRAPPC3, BET3; trafficking protein particle complex subunit 3 165.0 2.0 0.0 1.0 1.0 U 2.0 0.0 1.0 1.0 KOG3330 2.0 1.0 0.0 0 0 0 0 K20305 0.0057142857142857 0.0 TRAPPC8, TRS85; trafficking protein particle complex subunit 8 454.0 2.0 0.0 1.0 1.0 T 2.0 0.0 1.0 1.0 KOG1056 2.0 1.0 0.0 0 0 0 0 K20306 0.0028571428571428 0.0256410256410256 TRAPPC9, TRS120; trafficking protein particle complex subunit 9 20.0 20.0 0.0 1.0 1.0 E 1.0 19.0 1.0 1.0 COG2755 Lysophospholipase_L1_or_related_esterase._Includes_spore_coat_protein_LipC/YcsK TesA 20.0 0.05 0.95 0.0074855274065886 0.0167270380149154 0.0121062827107519 0.0092415106083267 0 0 0 0 K20308 0.0371428571428571 0.0 TRAPPC11; trafficking protein particle complex subunit 11 48.0 13.0 0.0 1.0 1.0 J 13.0 0.0 1.0 1.0 COG0199 Ribosomal_protein_S14 RpsN 13.0 1.0 0.0 0.985685416144876 0.96187782960917 0.9737816228770232 0.023807586535706 0 0 1 1 K20319 0.0 0.0085470085470085 blaADC; beta-lactamase class C ADC [EC:3.5.2.6] path:map01501 beta-Lactam resistance 375.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 3.0 0.0 1.0 0 0 0 0 K20320 0.0 0.0085470085470085 blaPDC; beta-lactamase class C PDC [EC:3.5.2.6] path:map01501 beta-Lactam resistance 375.0 3.0 0.0 1.0 1.0 V 0.0 3.0 1.0 1.0 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 3.0 0.0 1.0 0 0 0 0 K20326 0.0 0.0284900284900284 xagA; protein XagA path:map02024 Quorum sensing 225.0 0.0 10.0 4.0 0.4 2BCV0 10.0 0.0 1.0 0 0 0 0 K20327 0.0 0.0199430199430199 xagB; glycosyltransferase XagB path:map02024 Quorum sensing 461.0 6.0 5.0 2.0 0.857142857142857 M 0.0 7.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 7.0 0.0 1.0 0.0984699542098314 0.261650080306079 0.1800600172579552 0.1631801260962476 0 0 0 0 K20328 0.0 0.0028490028490028 xagC; membrane protein XagC path:map02024 Quorum sensing 501.0 0.0 1.0 1.0 1.0 2DQFH 1.0 0.0 1.0 0 0 0 0 K20331 0.0 0.0113960113960113 toxA; toxoflavin synthase [EC:2.1.1.349] path:map02024 Quorum sensing 142.0 2.0 0.0 2.0 0.5 Q 0.0 4.0 2.0 0.5 COG0500 SAM-dependent_methyltransferase SmtA 4.0 0.0 1.0 0.0143080845573343 0.0616651618071535 0.0379866231822439 0.0473570772498192 0 0 0 0 K20332 0.0 0.0142450142450142 toxC; toxoflavin biosynthesis protein ToxC path:map02024 Quorum sensing 370.0 4.0 3.0 2.0 0.8 S 0.0 5.0 2.0 0.8 COG2319 WD40_repeat WD40 5.0 0.0 1.0 0.0227006410362259 0.0427745338326589 0.0327375874344424 0.0200738927964329 0 0 0 0 K20333 0.0028571428571428 0.0455840455840455 toxD; toxoflavin biosynthesis protein ToxD path:map02024 Quorum sensing 116.0 7.0 2.0 7.0 0.333333333333333 S 1.0 20.0 2.0 0.904761904761905 COG1262 Formylglycine-generating_enzyme,_required_for_sulfatase_activity,_contains_SUMF1/FGE_domain YfmG 21.0 0.0476190476190476 0.9523809523809524 0.0215994928536038 0.0525438372669756 0.0370716650602897 0.0309443444133717 0 0 0 0 K20334 0.0 0.0085470085470085 cviR; LuxR family transcriptional regulator, quorum-sensing system regulator CviR path:map02024 Quorum sensing 87.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 3.0 0.0 1.0 0 0 0 0 K20337 0.0 0.0028490028490028 psmB; phenol-soluble modulin beta path:map02024 Quorum sensing 44.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2DIUC 5.0 0.0 1.0 1.05949802826511e-12 1.2301935615989e-17 5.29755165100363e-13 1.059485726329494e-12 0 0 0 0 K20338 0.0 0.0028490028490028 rot; MarR family transcriptional regulator, global regulator for virulence path:map02024 Quorum sensing 133.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 1.0 0.0 1.0 0 0 0 0 K20342 0.0 0.0056980056980056 comR; HTH-type transcriptional regulator, regulator for ComX path:map02024 Quorum sensing 106.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 2.0 0.0 1.0 0 0 0 0 K20344 0.0057142857142857 0.0541310541310541 blpA, lagD; ATP-binding cassette, subfamily C, bacteriocin exporter path:map02010,path:map02024 ABC transporters,Quorum sensing 610.0 38.0 0.0 1.0 1.0 V 2.0 30.0 2.0 0.974358974358975 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 32.0 0.0625 0.9375 0.0136563939737664 0.057699144686772 0.0356777693302692 0.0440427507130056 0 0 0 0 K20345 0.0057142857142857 0.0541310541310541 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter path:map02024 Quorum sensing 129.0 25.0 19.0 3.0 0.78125 M 3.0 29.0 4.0 0.78125 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 32.0 0.09375 0.90625 0.0090334419795709 0.341734697269699 0.1753840696246349 0.3327012552901281 0 0 0 0 K20370 0.0 0.0256410256410256 PEPCK; phosphoenolpyruvate carboxykinase (diphosphate) [EC:4.1.1.38] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 1103.0 9.0 0.0 1.0 1.0 S 0.0 9.0 1.0 1.0 28HY3 9.0 0.0 1.0 0.0450349525148583 0.129944673965495 0.0874898132401766 0.0849097214506367 0 0 0 0 K20373 0.0 0.0284900284900284 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator path:map02024 Quorum sensing 78.0 12.0 0.0 1.0 1.0 K 0.0 12.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 12.0 0.0 1.0 0.0289326170061759 0.0919763283044233 0.0604544726552996 0.0630437112982474 0 0 0 0 K20374 0.0 0.017094017094017 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor path:map02024 Quorum sensing 136.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 7.0 0.0 1.0 0.0156731027556424 0.0265419834595407 0.0211075431075915 0.0108688807038982 0 0 0 0 K20375 0.0 0.0113960113960113 ropB, rgg1; HTH-type transcriptional regulator, pheromone-responsive regulator path:map02024 Quorum sensing 69.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 4.0 0.0 1.0 0.0647573253230938 0.132408211961888 0.0985827686424909 0.0676508866387942 0 0 0 0 K20379 0.0 0.0085470085470085 cad; sex pheromone cAD1 path:map02024 Quorum sensing 131.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 COG4939 Membrane-anchored_lipoprotein_Tpp15,_major_membrane_immunogen Tpp15 3.0 0.0 1.0 0 0 0 0 K20382 0.0 0.0028490028490028 asa1; aggregation substance path:map02024 Quorum sensing 381.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 COG3087 Cell_division_protein_FtsN FtsN 1.0 0.0 1.0 0 0 0 0 K20385 0.0 0.0028490028490028 cylM; CylM protein path:map02024 Quorum sensing 1014.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG4403 Lantibiotic_modifying_enzyme LcnDR2 1.0 0.0 1.0 0 0 0 0 K20386 0.0028571428571428 0.0113960113960113 cylB; ATP-binding cassette, subfamily B, bacterial CylB path:map02010,path:map02024 ABC transporters,Quorum sensing 607.0 5.0 0.0 1.0 1.0 V 1.0 4.0 1.0 1.0 COG2274 ABC-type_bacteriocin/lantibiotic_exporters,_contain_an_N-terminal_double-glycine_peptidase_domain SunT 5.0 0.2 0.8 0.0968696804129014 0.231917496904407 0.1643935886586542 0.1350478164915056 0 0 0 0 K20388 0.0 0.0028490028490028 cylR2; HTH-type transcriptional regulator, cytolysin regulator path:map02024 Quorum sensing 69.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1476 DNA-binding_transcriptional_regulator,_XRE-family_HTH_domain XRE 1.0 0.0 1.0 0 0 0 0 K20391 0.0 0.0256410256410256 plcR; HTH-type transcriptional regulator, pleiotropic regulator of extracellular virulence genes path:map02024 Quorum sensing 63.0 9.0 0.0 1.0 1.0 K 0.0 9.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 9.0 0.0 1.0 0.0349633599186449 0.0805977010694108 0.0577805304940278 0.0456343411507659 0 0 0 0 K20402 0.0 0.0028490028490028 DEPTOR; DEP domain-containing mTOR-interacting protein path:map04140,path:map04150 Autophagy - animal,mTOR signaling pathway 288.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28JRH 1.0 0.0 1.0 0 0 0 0 K20404 0.0028571428571428 0.0 DEPDC5, SEA1; SEA/GATOR complex protein SEA1/DEPDC5 path:map04150 mTOR signaling pathway 329.0 1.0 0.0 1.0 1.0 P 1.0 0.0 1.0 1.0 COG0387 Cation_(Ca2+/Na+/K+)/H+_antiporter_ChaA ChaA 1.0 1.0 0.0 0 0 0 0 K20415 0.0028571428571428 0.0 madH; ACP-SH:acetate ligase [EC:6.2.1.35] 372.0 1.0 0.0 1.0 1.0 2EWC6 1.0 1.0 0.0 0 0 0 0 K20418 0.0 0.0028490028490028 ido; L-isoleucine 4-hydroxylase [EC:1.14.11.45] 250.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG4340 Predicted_dioxygenase,_2-oxoglutarate_and_Fe-dependent_(2OG-Fe)_dioxygenase_superfamily 1.0 0.0 1.0 0 0 0 0 K20420 0.0 0.0199430199430199 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 352.0 9.0 4.0 2.0 0.642857142857143 Q 0.0 14.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 14.0 0.0 1.0 0.0002278298168501 0.0006842587887684 0.0004560443028092 0.0004564289719183 0 0 0 0 K20421 0.0028571428571428 0.037037037037037 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 115.0 6.0 1.0 5.0 0.352941176470588 Q 1.0 16.0 4.0 0.352941176470588 COG0500 SAM-dependent_methyltransferase SmtA 17.0 0.0588235294117647 0.9411764705882352 0.0179980766647148 0.0819505774422695 0.0499743270534921 0.0639525007775547 0 0 0 0 K20422 0.0 0.0085470085470085 ncsB; neocarzinostatin naphthoate synthase [EC:2.3.1.237] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 1615.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 3.0 0.0 1.0 0 0 0 0 K20423 0.0 0.0142450142450142 ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 539.0 5.0 0.0 1.0 1.0 Q 0.0 5.0 1.0 1.0 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 5.0 0.0 1.0 0.0023027026659718 0.0079855444672859 0.0051441235666288 0.005682841801314 0 0 0 0 K20424 0.0 0.0028490028490028 acbL; 2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 486.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 1.0 0.0 1.0 0 0 0 0 K20427 0.0 0.0085470085470085 acbR, vldB; valienol-1-phosphate guanylyltransferase [EC:2.7.7.91] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 392.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG0448 Glucose-1-phosphate_adenylyltransferase_(ADP-glucose_pyrophosphorylase) GlgC 3.0 0.0 1.0 0 0 0 0 K20428 0.0114285714285714 0.0028490028490028 acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 381.0 5.0 0.0 1.0 1.0 E 4.0 1.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 5.0 0.8 0.2 0.110369180806071 0.332954100647171 0.221661640726621 0.2225849198411 0 0 0 0 K20429 0.0114285714285714 0.0854700854700854 vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33] path:map00541,path:map01100,path:map01250 O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 303.0 32.0 30.0 2.0 0.941176470588235 E 4.0 30.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 34.0 0.1176470588235294 0.8823529411764706 0.0441291915041519 0.164548891935365 0.1043390417197584 0.1204197004312131 0 0 0 0 K20430 0.0 0.0113960113960113 acbS; glycosyltransferase AcbS [EC:2.4.-.-] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 281.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG0297 Glycogen_synthase GlgA 4.0 0.0 1.0 0.127242760097717 0.243215908476871 0.185229334287294 0.1159731483791539 0 0 0 0 K20431 0.0 0.037037037037037 cetB, valD; 2-epi-5-epi-valiolone epimerase [EC:5.1.3.33] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 121.0 13.0 0.0 1.0 1.0 E 0.0 13.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 13.0 0.0 1.0 0.0962804998470972 0.656649034528548 0.3764647671878225 0.5603685346814508 0 0 0 0 K20432 0.0 0.017094017094017 valK; 5-epi-valiolone dehydratase [EC:4.2.1.-] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 256.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG1091 dTDP-4-dehydrorhamnose_reductase RfbD 6.0 0.0 1.0 0.100600540803908 0.200449908960295 0.1505252248821015 0.099849368156387 0 0 0 0 K20433 0.0 0.0313390313390313 valC; C7-cyclitol 7-kinase [EC:2.7.1.214] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 232.0 11.0 10.0 2.0 0.916666666666667 GK 0.0 12.0 1.0 1.0 COG1940 Sugar_kinase_of_the_NBD/HSP70_family,_may_contain_an_N-terminal_HTH_domain NagC 12.0 0.0 1.0 0.0524486233612657 0.1319143974448 0.0921815104030328 0.0794657740835343 0 0 0 0 K20435 0.0057142857142857 0.0056980056980056 valM; validone 7-phosphate aminotransferase [EC:2.6.1.-] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 372.0 4.0 0.0 1.0 1.0 E 2.0 2.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 4.0 0.5 0.5 0.122173326691824 0.363783282636536 0.24297830466418 0.2416099559447119 0 0 0 0 K20436 0.0 0.0199430199430199 valL, salC; validamine 7-phosphate valienyltransferase [EC:2.5.1.135] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 531.0 7.0 0.0 1.0 1.0 G 0.0 7.0 1.0 1.0 COG0380 Trehalose-6-phosphate_synthase,_GT20_family OtsA 7.0 0.0 1.0 0.0606689354797584 0.108216670700159 0.0844428030899587 0.0475477352204006 0 0 0 0 K20438 0.0028571428571428 0.0113960113960113 valG; validoxylamine A glucosyltransferase [EC:2.4.1.338] path:map00525,path:map01100,path:map01110 Acarbose and validamycin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 265.0 2.0 0.0 3.0 0.4 S 1.0 4.0 1.0 1.0 COG1216 Glycosyltransferase,_GT2_family WcaE 5.0 0.2 0.8 0.0831241183777981 0.181614936382222 0.13236952738001 0.0984908180044239 0 0 0 0 K20444 0.0 0.0 rfbC; O-antigen biosynthesis protein [EC:2.4.1.-] 223.0 185.0 17.0 0.583769633507853 M 0.0 0.0 27.0 0.297650130548303 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 0.0 0 0 0 0 K20445 0.0 0.0113960113960113 ndhF; nicotinate dehydrogenase FAD-subunit [EC:1.17.1.5] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 278.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1319 Aldehyde,_CO,_or_xanthine_dehydrogenase,_FAD-binding_subunit CutB 4.0 0.0 1.0 0.015238366524158 0.0557194068600271 0.0354788866920925 0.0404810403358691 0 0 0 0 K20446 0.0114285714285714 0.0113960113960113 ndhS; nicotinate dehydrogenase small FeS subunit [EC:1.17.1.5] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 150.0 9.0 0.0 1.0 1.0 C 4.0 5.0 1.0 1.0 COG2080 Aldehyde,_CO,_or_xanthine_dehydrogenase,_Fe-S_subunit,_CoxS/CutS_family CutS 9.0 0.4444444444444444 0.5555555555555556 0.579510307227286 0.502161908133186 0.5408361076802359 0.0773483990941 0 1 0 1 K20447 0.0028571428571428 0.037037037037037 ndhL; nicotinate dehydrogenase large molybdopterin subunit [EC:1.17.1.5] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 408.0 17.0 0.0 1.0 1.0 C 1.0 15.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 16.0 0.0625 0.9375 0.18526139776781 0.0642096702102105 0.1247355339890102 0.1210517275575995 0 0 0 0 K20448 0.0 0.0199430199430199 ndhM; nicotinate dehydrogenase medium molybdopterin subunit [EC:1.17.1.5] path:map00760,path:map01100,path:map01120 Nicotinate and nicotinamide metabolism,Metabolic pathways,Microbial metabolism in diverse environments 320.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG1529 Aldehyde,_CO_or_xanthine_dehydrogenase,_Mo-binding_subunit CoxL 7.0 0.0 1.0 0.0294754983475716 0.119048379131934 0.0742619387397528 0.0895728807843624 0 0 0 0 K20449 0.0057142857142857 0.0427350427350427 hnr; 6-hydroxynicotinate reductase [EC:1.3.7.1] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 116.0 13.0 8.0 2.0 0.722222222222222 L 2.0 16.0 3.0 0.722222222222222 COG2816 NADH_pyrophosphatase_NudC,_Nudix_superfamily NPY1 18.0 0.1111111111111111 0.8888888888888888 0.274122591630172 0.463249782392025 0.3686861870110985 0.189127190761853 0 0 0 0 K20450 0.0 0.0028490028490028 mgm; 2-methyleneglutarate mutase [EC:5.4.99.4] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 616.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG2185 Methylmalonyl-CoA_mutase,_C-terminal_domain/subunit_(cobalamin-binding) Sbm 1.0 0.0 1.0 0 0 0 0 K20451 0.0028571428571428 0.0085470085470085 mii; methylitaconate Delta-isomerase [EC:5.3.3.6] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 373.0 4.0 0.0 1.0 1.0 S 1.0 3.0 1.0 1.0 COG2828 2-Methylaconitate_cis-trans-isomerase_PrpF_(2-methyl_citrate_pathway) PrpF 4.0 0.25 0.75 0.0768943139275302 0.16984524221756 0.1233697780725451 0.0929509282900298 0 0 0 0 K20452 0.0114285714285714 0.0484330484330484 dmdA; dimethylmaleate hydratase large subunit [EC:4.2.1.85] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 412.0 13.0 4.0 2.0 0.590909090909091 E 4.0 18.0 1.0 1.0 COG0065 Homoaconitase/3-isopropylmalate_dehydratase_large_subunit LeuC 22.0 0.1818181818181818 0.8181818181818182 0.061675543970164 0.604868771342684 0.333272157656424 0.5431932273725201 0 0 0 0 K20453 0.0028571428571428 0.0484330484330484 dmdB; dimethylmaleate hydratase small subunit [EC:4.2.1.85] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 161.0 19.0 0.0 1.0 1.0 E 1.0 18.0 1.0 1.0 COG0066 3-isopropylmalate_dehydratase_small_subunit LeuD 19.0 0.0526315789473684 0.9473684210526316 0.0232169178376805 0.061497735927669 0.0423573268826747 0.0382808180899885 0 0 0 0 K20454 0.0114285714285714 0.0313390313390313 dml; 2,3-dimethylmalate lyase [EC:4.1.3.32] path:map00760,path:map01120 Nicotinate and nicotinamide metabolism,Microbial metabolism in diverse environments 278.0 12.0 10.0 3.0 0.8 G 4.0 11.0 1.0 1.0 COG2513 2-Methylisocitrate_lyase_and_related_enzymes,_PEP_mutase_family PrpB 15.0 0.2666666666666666 0.7333333333333333 0.179732924180726 0.308138727166262 0.243935825673494 0.128405802985536 0 0 0 0 K20455 0.0 0.037037037037037 acnD; 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) [EC:4.2.1.117] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 856.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 COG1048 Aconitase_A AcnA 14.0 0.0 1.0 0.0268004292286611 0.0421544284461111 0.0344774288373861 0.0153539992174499 0 0 0 0 K20459 0.0142857142857142 0.0541310541310541 nukF, mcdF, sboF; lantibiotic transport system ATP-binding protein path:map02010 ABC transporters 187.0 27.0 25.0 3.0 0.9 V 5.0 25.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 30.0 0.1666666666666666 0.8333333333333334 0.129032718417757 0.0610101897387229 0.0950214540782399 0.068022528679034 0 0 0 0 K20460 0.0 0.037037037037037 nukE, mcdE, sboE; lantibiotic transport system permease protein path:map02010 ABC transporters 214.0 12.0 10.0 2.0 0.857142857142857 S 0.0 14.0 2.0 0.857142857142857 COG4200 Predicted_lantabiotic-exporting_membrane_pepmease,_EfiE/EfiG/ABC2_family EfiE 14.0 0.0 1.0 0.0290996927479847 0.0589105652488493 0.044005128998417 0.0298108725008646 0 0 0 0 K20461 0.0 0.0455840455840455 nukG, mcdG, sboG; lantibiotic transport system permease protein path:map02010 ABC transporters 197.0 15.0 13.0 2.0 0.882352941176471 S 0.0 17.0 1.0 1.0 COG4200 Predicted_lantabiotic-exporting_membrane_pepmease,_EfiE/EfiG/ABC2_family EfiE 17.0 0.0 1.0 0.0460905018811471 0.107628801789098 0.0768596518351225 0.0615382999079509 0 0 0 0 K20466 0.0 0.0085470085470085 mmpL11; heme transporter 659.0 2.0 0.0 2.0 0.5 D 0.0 4.0 1.0 1.0 COG2409 Predicted_lipid_transporter_YdfJ,_MMPL/SSD_domain,_RND_superfamily YdfJ 4.0 0.0 1.0 0.0322464648311491 0.0495915314845591 0.0409189981578541 0.01734506665341 0 0 0 0 K20467 0.0 0.0028490028490028 K20467; heme-binding protein 180.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2APGR 1.0 0.0 1.0 0 0 0 0 K20468 0.0142857142857142 0.0398860398860398 K20468; putative heme transporter 247.0 14.0 4.0 2.0 0.583333333333333 S 5.0 19.0 1.0 1.0 COG0392 Predicted_membrane_flippase_AglD2/YbhN,_UPF0104_family AglD2 24.0 0.2083333333333333 0.7916666666666666 0.0069206446606989 0.120284814951403 0.0636027298060509 0.1133641702907041 0 0 0 0 K20469 0.0 0.0598290598290598 K20469; putative heme transporter 320.0 23.0 20.0 2.0 0.884615384615385 S 0.0 26.0 1.0 1.0 COG0628 Predicted_PurR-regulated_permease_PerM PerM 26.0 0.0 1.0 0.0273271588839291 0.0085788815830564 0.0179530202334927 0.0187482773008727 0 0 0 0 K20470 0.0 0.0227920227920227 mmpL3; trehalose monomycolate/heme transporter 670.0 7.0 5.0 3.0 0.7 S 0.0 10.0 1.0 1.0 COG2409 Predicted_lipid_transporter_YdfJ,_MMPL/SSD_domain,_RND_superfamily YdfJ 10.0 0.0 1.0 0.0116761916324597 0.0269820147840402 0.0193291032082499 0.0153058231515805 0 0 0 0 K20480 0.0 0.037037037037037 nprR, nprA; HTH-type transcriptional regulator, quorum sensing regulator NprR path:map02024 Quorum sensing 54.0 18.0 0.0 1.0 1.0 K 0.0 18.0 2.0 0.722222222222222 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 18.0 0.0 1.0 0.0177599818864035 0.037040637175915 0.0274003095311592 0.0192806552895115 0 0 0 0 K20483 0.0 0.0484330484330484 nisB, spaB, epiB; lantibiotic biosynthesis protein path:map02020,path:map02024 Two-component system,Quorum sensing 209.0 22.0 18.0 2.0 0.846153846153846 S 0.0 25.0 3.0 0.769230769230769 2C4IS 25.0 0.0 1.0 0.0116044795281602 0.0238110003779737 0.0177077399530669 0.0122065208498135 0 0 0 0 K20484 0.0 0.037037037037037 nisC, spaC, epiC; lantibiotic biosynthesis protein path:map02020,path:map02024 Two-component system,Quorum sensing 246.0 21.0 0.0 1.0 1.0 V 0.0 21.0 1.0 1.0 COG4403 Lantibiotic_modifying_enzyme LcnDR2 21.0 0.0 1.0 0.0050660925638478 0.0160879683853341 0.0105770304745909 0.0110218758214863 0 0 0 0 K20485 0.0 0.0142450142450142 nisT, spaT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT path:map02020,path:map02024 Two-component system,Quorum sensing 404.0 7.0 0.0 1.0 1.0 V 0.0 7.0 1.0 1.0 COG1132 ABC-type_multidrug_transport_system,_ATPase_and_permease_component MdlB 7.0 0.0 1.0 0.0098137036677481 0.453153321619487 0.2314835126436175 0.4433396179517389 0 0 0 0 K20486 0.0 0.0142450142450142 nisP, epiP; lantibiotic leader peptide-processing serine protease [EC:3.4.21.-] path:map02020,path:map02024 Two-component system,Quorum sensing 294.0 9.0 0.0 1.0 1.0 O 0.0 9.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 9.0 0.0 1.0 0.0230693681987627 0.175444146540003 0.0992567573693828 0.1523747783412403 0 0 0 0 K20487 0.0 0.0484330484330484 nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] path:map02020,path:map02024 Two-component system,Quorum sensing 246.0 18.0 0.0 1.0 1.0 T 0.0 18.0 4.0 0.555555555555556 COG0642 Signal_transduction_histidine_kinase BaeS 18.0 0.0 1.0 0.841567208515537 0.44402514794939 0.6427961782324635 0.397542060566147 0 0 1 1 K20488 0.0 0.037037037037037 nisR, spaR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR path:map02020,path:map02024 Two-component system,Quorum sensing 217.0 7.0 2.0 3.0 0.4375 T 0.0 16.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 16.0 0.0 1.0 0.0064675615480081 0.0113287011084111 0.0088981313282096 0.004861139560403 0 0 0 0 K20490 0.0057142857142857 0.0227920227920227 nisF, spaF, cprA, epiF; lantibiotic transport system ATP-binding protein path:map02010,path:map02020,path:map02024 ABC transporters,Two-component system,Quorum sensing 201.0 11.0 0.0 1.0 1.0 V 2.0 9.0 1.0 1.0 COG1131 ABC-type_multidrug_transport_system,_ATPase_component CcmA 11.0 0.1818181818181818 0.8181818181818182 0.0909291730654733 0.133496221072218 0.1122126970688456 0.0425670480067447 0 0 0 0 K20491 0.0028571428571428 0.0227920227920227 nisE, spaE, cprB, epiE; lantibiotic transport system permease protein path:map02010,path:map02020,path:map02024 ABC transporters,Two-component system,Quorum sensing 209.0 7.0 5.0 2.0 0.777777777777778 S 1.0 8.0 2.0 0.777777777777778 COG4200 Predicted_lantabiotic-exporting_membrane_pepmease,_EfiE/EfiG/ABC2_family EfiE 9.0 0.1111111111111111 0.8888888888888888 0.0267525486265383 0.0539630880533628 0.0403578183399505 0.0272105394268244 0 0 0 0 K20492 0.0 0.017094017094017 nisG, spaG, cprC; lantibiotic transport system permease protein path:map02010,path:map02020,path:map02024 ABC transporters,Two-component system,Quorum sensing 232.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 COG4200 Predicted_lantabiotic-exporting_membrane_pepmease,_EfiE/EfiG/ABC2_family EfiE 6.0 0.0 1.0 0.0169150431053661 0.135648897458337 0.0762819702818515 0.1187338543529709 0 0 0 0 K20497 0.0 0.0256410256410256 CYP124; methyl-branched lipid omega-hydroxylase [EC:1.14.15.14] 388.0 17.0 16.0 2.0 0.944444444444444 Q 0.0 18.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 18.0 0.0 1.0 0.0001174052457457 3.7031174705015e-05 7.72182102253575e-05 8.0374071040685e-05 0 0 0 0 K20498 0.0057142857142857 0.0 DSD1; D-serine ammonia-lyase [EC:4.3.1.18] path:map00260,path:map00470,path:map01100 Glycine, serine and threonine metabolism,D-Amino acid metabolism,Metabolic pathways 378.0 2.0 0.0 1.0 1.0 E 2.0 0.0 1.0 1.0 COG3616 D-serine_deaminase,_pyridoxal_phosphate-dependent Dsd1 2.0 1.0 0.0 0 0 0 0 K20500 0.0 0.0085470085470085 rapL; L-lysine cyclodeaminase [EC:4.3.1.28] 293.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 3.0 0.0 1.0 0 0 0 0 K20509 0.0 0.0028490028490028 madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase [EC:7.2.4.1] path:map00362,path:map00620,path:map00650,path:map01100,path:map01120 Benzoate degradation,Pyruvate metabolism,Butanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 400.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1883 Na+-transporting_oxaloacetate/methylmalonyl-CoA_decarboxylase,_beta_subunit OadB 2.0 0.0 1.0 0 0 0 0 K20525 0.0 0.017094017094017 alg17C; oligo-alginate lyase [EC:4.2.2.26] 691.0 7.0 0.0 1.0 1.0 S 0.0 7.0 2.0 0.857142857142857 28HPB 7.0 0.0 1.0 0.0331318016595156 0.0804964647427898 0.0568141332011527 0.0473646630832742 0 0 0 0 K20527 0.0 0.0626780626780626 trbB; type IV secretion system protein TrbB [EC:7.4.2.8] path:map02024 Quorum sensing 292.0 45.0 0.0 1.0 1.0 U 0.0 45.0 1.0 1.0 COG4962 Pilus_assembly_protein,_ATPase_of_CpaF_family CpaF 45.0 0.0 1.0 0.0102105438597688 0.0275760872330952 0.0188933155464319 0.0173655433733263 0 0 0 0 K20528 0.0 0.0398860398860398 trbC; type IV secretion system protein TrbC path:map02024 Quorum sensing 102.0 31.0 0.0 1.0 1.0 U 0.0 31.0 1.0 1.0 COG3838 Type_IV_secretory_pathway,_VirB2_component_(pilin) VirB2 31.0 0.0 1.0 0.0135058649318492 0.031467031392279 0.0224864481620641 0.0179611664604298 0 0 0 0 K20529 0.0 0.037037037037037 trbD; type IV secretion system protein TrbD path:map02024 Quorum sensing 80.0 28.0 26.0 3.0 0.903225806451613 NU 0.0 31.0 3.0 0.903225806451613 COG5268 Type_IV_secretory_pathway,_TrbD_component TrbD 31.0 0.0 1.0 0.0106757286320751 0.0176901727013401 0.0141829506667076 0.007014444069265 0 0 0 0 K20530 0.0 0.0683760683760683 trbE; type IV secretion system protein TrbE [EC:7.4.2.8] path:map02024 Quorum sensing 613.0 52.0 51.0 2.0 0.981132075471698 U 0.0 53.0 2.0 0.962264150943396 COG3451 Type_IV_secretory_pathway,_VirB4_component VirB4 53.0 0.0 1.0 0.0078981851397066 0.0142015017663196 0.0110498434530131 0.0063033166266129 0 0 0 0 K20531 0.0 0.0541310541310541 trbF; type IV secretion system protein TrbF path:map02024 Quorum sensing 206.0 43.0 0.0 1.0 1.0 U 0.0 43.0 2.0 0.976744186046512 COG3701 Type_IV_secretory_pathway,_TrbF_component TrbF 43.0 0.0 1.0 0.0074343350736261 0.0204275116597182 0.0139309233666721 0.012993176586092 0 0 0 0 K20532 0.0 0.0569800569800569 trbG; type IV secretion system protein TrbG path:map02024 Quorum sensing 192.0 47.0 0.0 1.0 1.0 U 0.0 47.0 1.0 1.0 COG3504 Type_IV_secretory_pathway,_VirB9_components VirB9 47.0 0.0 1.0 0.0109964422773561 0.083865701241687 0.0474310717595215 0.0728692589643309 0 0 0 0 K20533 0.0 0.0569800569800569 trbI; type IV secretion system protein TrbI path:map02024 Quorum sensing 277.0 47.0 0.0 1.0 1.0 U 0.0 47.0 1.0 1.0 COG2948 Type_IV_secretory_pathway,_VirB10_component VirB10 47.0 0.0 1.0 0.0084850593927252 0.0267111961190791 0.0175981277559021 0.0182261367263539 0 0 0 0 K20534 0.0285714285714285 0.3162393162393162 gtrB; polyisoprenyl-phosphate glycosyltransferase [EC:2.4.-.-] 209.0 153.0 149.0 2.0 0.974522292993631 M 11.0 146.0 3.0 0.815286624203822 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 157.0 0.0700636942675159 0.929936305732484 0.0409322753987082 0.517835423562523 0.2793838494806156 0.4769031481638148 0 0 0 0 K20539 0.0 0.0284900284900284 blcR; IclR family transcriptional regulator, blcABC operon repressor path:map02024 Quorum sensing 249.0 10.0 0.0 1.0 1.0 K 0.0 10.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 10.0 0.0 1.0 0.0090426079597933 0.0188939779431201 0.0139682929514566 0.0098513699833267 0 0 0 0 K20540 0.0 0.0028490028490028 cepR2; LuxR family transcriptional regulator, quorum-sensing system regulator CepR2 path:map02024 Quorum sensing 150.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 1.0 0.0 1.0 0 0 0 0 K20541 0.0114285714285714 0.0911680911680911 bcsB; cellulose synthase operon protein B 23.0 15.0 6.0 7.0 0.365853658536585 M 5.0 36.0 7.0 0.390243902439024 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 41.0 0.1219512195121951 0.8780487804878049 0.0548734490939624 0.0993467867747062 0.0771101179343343 0.0444733376807437 0 0 0 0 K20542 0.0 0.0598290598290598 bcsZ; endoglucanase [EC:3.2.1.4] 229.0 22.0 0.0 1.0 1.0 G 0.0 22.0 1.0 1.0 COG3405 Endo-1,4-beta-D-glucanase_Y BcsZ 22.0 0.0 1.0 0.0484182183153535 0.125681600401955 0.0870499093586542 0.0772633820866015 0 0 0 0 K20543 0.0 0.0 bcsC; cellulose synthase operon protein C 25.0 9.0 12.0 0.324675324675325 O 0.0 0.0 14.0 0.292682926829268 COG0457 Tetratricopeptide_(TPR)_repeat TPR 0.0 0 0 0 0 K20547 0.0 0.0056980056980056 CHIB; basic endochitinase B [EC:3.2.1.14] path:map00520,path:map01100,path:map04016 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,MAPK signaling pathway - plant 519.0 1.0 0.0 2.0 0.5 E 0.0 2.0 2.0 0.5 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 2.0 0.0 1.0 0 0 0 0 K20549 0.0 0.0085470085470085 aci; 3,6-anhydro-L-galactonate cycloisomerase [EC:5.5.1.25] 337.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 3.0 0.0 1.0 0 0 0 0 K20608 0.0371428571428571 0.0 tet; tetrahedral aminopeptidase [EC:3.4.11.-] 336.0 21.0 0.0 1.0 1.0 G 21.0 0.0 1.0 1.0 COG1363 Putative_aminopeptidase_FrvX FrvX 21.0 1.0 0.0 0.0022214257383928 6.899004003034e-05 0.0011452078892115 0.0021524356983624 0 0 0 0 K20609 0.0028571428571428 0.0142450142450142 sgcX; putative aminopeptidase [EC:3.4.11.-] 337.0 7.0 6.0 2.0 0.875 G 1.0 7.0 1.0 1.0 COG1363 Putative_aminopeptidase_FrvX FrvX 8.0 0.125 0.875 7.89197733399467e-12 0.0795345741489482 0.03976728707842 0.0795345741410562 0 0 0 0 K20611 0.1742857142857143 0.0056980056980056 crtD; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase [EC:1.3.99.37] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 469.0 75.0 0.0 1.0 1.0 Q 73.0 2.0 1.0 1.0 COG1233 Phytoene_dehydrogenase-related_protein 75.0 0.9733333333333334 0.0266666666666666 0.0195161209490368 0.010839869307348 0.0151779951281923 0.0086762516416887 0 0 0 0 K20614 0.0028571428571428 0.0 ldi; linalool dehydratase / geraniol isomerase [EC:4.2.1.127 5.4.4.4] 547.0 1.0 0.0 1.0 1.0 28IIF 1.0 1.0 0.0 0 0 0 0 K20616 0.2028571428571428 0.0085470085470085 lyeJ; lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming) [EC:2.5.1.150] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 228.0 69.0 61.0 2.0 0.896103896103896 H 74.0 3.0 1.0 1.0 COG0382 4-hydroxybenzoate_polyprenyltransferase UbiA 77.0 0.961038961038961 0.0389610389610389 0.90709390353746 0.862344345228498 0.8847191243829791 0.0447495583089619 0 0 1 1 K20626 0.0 0.0056980056980056 lcdA; lactoyl-CoA dehydratase subunit alpha [EC:4.2.1.54] path:map00640,path:map00643,path:map01100,path:map01120 Propanoate metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 11.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 4.0 0.0 1.0 2.01930294070064e-12 0.0320262804185085 0.0160131402102639 0.0320262804164892 0 0 0 0 K20627 0.0 0.0056980056980056 lcdB; lactoyl-CoA dehydratase subunit beta [EC:4.2.1.54] path:map00640,path:map00643,path:map01100,path:map01120 Propanoate metabolism,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 372.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 3.0 0.0 1.0 0 0 0 0 K20628 0.0 0.0398860398860398 exlX; expansin 136.0 17.0 0.0 1.0 1.0 G 0.0 17.0 4.0 0.470588235294118 COG4305 Peptidoglycan-binding_domain,_expansin_YoaJ YoaJ 17.0 0.0 1.0 0.0419535014040105 0.297098531330857 0.1695260163674337 0.2551450299268465 0 0 0 0 K20656 0.0 0.0056980056980056 TMEM189; plasmanylethanolamine desaturase [EC:1.14.19.77] path:map00565,path:map01100 Ether lipid metabolism,Metabolic pathways 203.0 2.0 0.0 1.0 1.0 I 0.0 2.0 2.0 0.5 COG3000 Sterol_desaturase/sphingolipid_hydroxylase,_fatty_acid_hydroxylase_superfamily ERG3 2.0 0.0 1.0 0 0 0 0 K20657 0.0057142857142857 0.0 CPS-KS; ent-copalyl diphosphate/ent-kaurene synthase [EC:5.5.1.13 4.2.3.19] path:map00904,path:map01100,path:map01110 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 468.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 2CKJS 2.0 1.0 0.0 0 0 0 0 K20707 0.0 0.0313390313390313 E5.1.1.5; lysine racemase [EC:5.1.1.5] 355.0 6.0 1.0 2.0 0.545454545454545 E 0.0 11.0 1.0 1.0 COG0787 Alanine_racemase Alr 11.0 0.0 1.0 0.007845427692662 0.0054070824864955 0.0066262550895787 0.0024383452061664 0 0 0 0 K20708 0.0028571428571428 0.0085470085470085 E5.1.1.21; isoleucine 2-epimerase [EC:5.1.1.21] 407.0 4.0 0.0 1.0 1.0 E 1.0 3.0 1.0 1.0 COG0160 Acetylornithine_aminotransferase/4-aminobutyrate_aminotransferase ArgD 4.0 0.25 0.75 0.0824026883524795 0.135359064370761 0.1088808763616202 0.0529563760182815 0 0 0 0 K20712 0.0 0.0142450142450142 glnA; 3-(hydroxyamino)phenol mutase [EC:5.4.4.3] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 469.0 3.0 1.0 2.0 0.6 E 0.0 5.0 1.0 1.0 COG0174 Glutamine_synthetase GlnA 5.0 0.0 1.0 2.26897460797586e-07 5.91544627105066e-06 3.071171865924123e-06 5.6885488102530745e-06 0 0 0 0 K20713 0.0 0.0085470085470085 rpcG; R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase [EC:4.4.1.33] path:map00196,path:map01100 Photosynthesis - antenna proteins,Metabolic pathways 256.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1413 HEAT_repeat HEAT 3.0 0.0 1.0 0 0 0 0 K20742 0.0057142857142857 0.0683760683760683 ykfC; gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13] 150.0 24.0 21.0 2.0 0.888888888888889 M 2.0 25.0 2.0 0.777777777777778 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 27.0 0.074074074074074 0.925925925925926 0.0827789104582336 0.154309024791579 0.1185439676249063 0.0715301143333454 0 0 0 0 K20754 0.0085714285714285 0.017094017094017 pstI; aqualysin 1 [EC:3.4.21.111] 311.0 12.0 0.0 1.0 1.0 O 3.0 9.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 12.0 0.25 0.75 0.011549959762943 0.0190614436697375 0.0153057017163402 0.0075114839067944 0 0 0 0 K20755 0.0 0.0085470085470085 E3.4.21.121; Lys-Lys/Arg-Xaa endopeptidase [EC:3.4.21.121] 485.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 1.0 1.0 COG1404 Serine_protease,_subtilisin_family AprE 3.0 0.0 1.0 0 0 0 0 K20757 0.0171428571428571 0.0655270655270655 dthadh; threo-3-hydroxy-D-aspartate ammonia-lyase [EC:4.3.1.27] 250.0 31.0 29.0 2.0 0.939393939393939 E 8.0 25.0 2.0 0.939393939393939 COG3616 D-serine_deaminase,_pyridoxal_phosphate-dependent Dsd1 33.0 0.2424242424242424 0.7575757575757576 0.120462471206692 0.674470143768355 0.3974663074875235 0.5540076725616631 0 0 0 0 K20760 0.0 0.0056980056980056 scnA; thiocyanate hydrolase subunit alpha [EC:3.5.5.8] 278.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DYBW 2.0 0.0 1.0 0 0 0 0 K20761 0.0 0.0056980056980056 scnB; thiocyanate hydrolase subunit beta [EC:3.5.5.8] 278.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DYBW 2.0 0.0 1.0 0 0 0 0 K20762 0.0 0.0085470085470085 scnC; thiocyanate hydrolase subunit gamma [EC:3.5.5.8] 197.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2BZ0R 3.0 0.0 1.0 0 0 0 0 K20765 0.0 0.0199430199430199 camK; 6-oxocamphor hydrolase [EC:3.7.1.18] 209.0 8.0 0.0 1.0 1.0 I 0.0 8.0 1.0 1.0 COG1024 Enoyl-CoA_hydratase/carnithine_racemase CaiD 8.0 0.0 1.0 0.010990209901869 0.0610456220169141 0.0360179159593915 0.0500554121150451 0 0 0 0 K20788 0.0 0.0113960113960113 mxaE; myxalamid-type polyketide synthase MxaE path:map01052 Type I polyketide structures 662.0 6.0 0.0 1.0 1.0 IQ 0.0 6.0 2.0 0.833333333333333 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 6.0 0.0 1.0 0.0043645691024921 0.0155266065893361 0.0099455878459141 0.011162037486844 0 0 0 0 K20791 0.0028571428571428 0.0 NAA10_11, ARD1_2; N-alpha-acetyltransferase 10/11 [EC:2.3.1.255] 160.0 1.0 0.0 1.0 1.0 K 1.0 0.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 1.0 1.0 0.0 0 0 0 0 K20793 0.0028571428571428 0.0 NAA50, NAT5; N-alpha-acetyltransferase 50 [EC:2.3.1.258] 158.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 COG0456 Ribosomal_protein_S18_acetylase_RimI_and_related_acetyltransferases RimI 1.0 1.0 0.0 0 0 0 0 K20801 0.0 0.0085470085470085 ltaA; L-allo-threonine aldolase [EC:4.1.2.49] path:map00260,path:map01100 Glycine, serine and threonine metabolism,Metabolic pathways 321.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG2008 Threonine_aldolase GLY1 3.0 0.0 1.0 0 0 0 0 K20807 0.0 0.0455840455840455 nthB; nitrile hydratase subunit beta [EC:4.2.1.84] path:map00364,path:map00380,path:map00627,path:map00643,path:map01100,path:map01120 Fluorobenzoate degradation,Tryptophan metabolism,Aminobenzoate degradation,Styrene degradation,Metabolic pathways,Microbial metabolism in diverse environments 71.0 23.0 14.0 3.0 0.696969696969697 S 0.0 28.0 5.0 0.363636363636364 28I45 28.0 0.0 1.0 0.0061205726559518 0.0165223667359445 0.0113214696959481 0.0104017940799926 0 0 0 0 K20810 0.06 0.1937321937321937 mqnX; aminodeoxyfutalosine deaminase [EC:3.5.4.40] path:map00130,path:map01100,path:map01110,path:map01240 Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 198.0 103.0 0.0 1.0 1.0 F 28.0 75.0 1.0 1.0 COG0402 Cytosine/adenosine_deaminase_or_related_metal-dependent_hydrolase SsnA 103.0 0.2718446601941747 0.7281553398058253 0.946920714099023 0.988147295610694 0.9675340048548584 0.041226581511671 1 1 1 1 K20811 0.0 0.0142450142450142 inuJ; inulosucrase [EC:2.4.1.9] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 78.0 4.0 2.0 3.0 0.571428571428571 M 0.0 7.0 3.0 0.428571428571429 COG1361 S-layer_protein_MJ0795,_predicted_component_of_type_IV_pili-like_system MJ0795 7.0 0.0 1.0 0.0266276307955552 0.0485170891420371 0.0375723599687961 0.0218894583464818 0 0 0 0 K20812 0.0171428571428571 0.0 glgA; glycogen synthase [EC:2.4.1.242] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 446.0 6.0 0.0 1.0 1.0 M 6.0 0.0 1.0 1.0 COG0297 Glycogen_synthase GlgA 6.0 1.0 0.0 1.7568369763783e-21 0.0077533148893706 0.0038766574446853 0.0077533148893706 0 0 0 0 K20813 0.0028571428571428 0.0 TDG; thymine-DNA glycosylase [EC:3.2.2.29] path:map03410 Base excision repair 207.0 1.0 0.0 1.0 1.0 2CGCP 1.0 1.0 0.0 0 0 0 0 K20814 0.0057142857142857 0.1054131054131054 dop; Pup amidohydrolase [EC:3.5.1.119] 416.0 38.0 32.0 2.0 0.863636363636364 S 2.0 42.0 2.0 0.977272727272727 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 44.0 0.0454545454545454 0.9545454545454546 0.0066568299536319 0.0313760546394309 0.0190164422965313 0.024719224685799 0 0 0 0 K20816 0.0 0.0085470085470085 sttH; streptothricin hydrolase [EC:3.5.2.19] 153.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1335 Nicotinamidase-related_amidase PncA 3.0 0.0 1.0 0 0 0 0 K20829 0.0 0.0028490028490028 celS; cellulose 1,4-beta-cellobiosidase [EC:3.2.1.176] 727.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG3934 Endo-1,4-beta-mannosidase 1.0 0.0 1.0 0 0 0 0 K20830 0.0028571428571428 0.0142450142450142 por; beta-porphyranase [EC:3.2.1.178] 233.0 7.0 0.0 1.0 1.0 G 1.0 6.0 1.0 1.0 COG2273 Beta-glucanase,_GH16_family BglS 7.0 0.1428571428571428 0.8571428571428571 0.0868279683335069 0.187778989217698 0.1373034787756024 0.1009510208841911 0 0 0 0 K20832 0.0 0.0085470085470085 EN3GAL; galactan endo-beta-1,3-galactanase [EC:3.2.1.181] 203.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG2273 Beta-glucanase,_GH16_family BglS 3.0 0.0 1.0 0 0 0 0 K20838 0.0057142857142857 0.0 NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-] path:map00480,path:map01100 Glutathione metabolism,Metabolic pathways 136.0 2.0 0.0 1.0 1.0 S 2.0 0.0 1.0 1.0 COG0456 Ribosomal_protein_S18_acetylase_RimI_and_related_acetyltransferases RimI 2.0 1.0 0.0 0 0 0 0 K20844 0.0 0.0085470085470085 abf1; non-reducing end alpha-L-arabinofuranosidase [EC:3.2.1.55] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 101.0 2.0 0.0 2.0 0.5 M 0.0 4.0 3.0 0.5 COG3250 Beta-galactosidase/beta-glucuronidase LacZ 4.0 0.0 1.0 5.50146074086898e-12 0.0879574525111413 0.0439787262583213 0.0879574525056398 0 0 0 0 K20846 0.0 0.0056980056980056 cgkA; kappa-carrageenase [EC:3.2.1.83] 272.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG2273 Beta-glucanase,_GH16_family BglS 5.0 0.0 1.0 0.0069090658252754 3.0924135938899797e-12 0.0034545329141839 0.0069090658221829 0 0 0 0 K20847 0.0 0.0028490028490028 g2d; glucan 1,6-alpha-isomaltosidase [EC:3.2.1.94] 406.0 2.0 0.0 1.0 1.0 G 0.0 2.0 2.0 0.5 COG4447 Uncharacterized_conserved_protein_related_to_plant_photosystem_II_stability/assembly_factor 2.0 0.0 1.0 0 0 0 0 K20850 0.0 0.0113960113960113 cgiA; iota-carrageenase [EC:3.2.1.157] 459.0 5.0 0.0 1.0 1.0 M 0.0 5.0 2.0 0.6 COG5434 Polygalacturonase Pgu1 5.0 0.0 1.0 0.0410113973042696 0.0876711221426875 0.0643412597234785 0.0466597248384179 0 0 0 0 K20859 0.0142857142857142 0.0911680911680911 phnPP; phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [EC:3.1.4.57] path:map00440 Phosphonate and phosphinate metabolism 200.0 39.0 38.0 2.0 0.975 S 5.0 35.0 1.0 1.0 COG0613 5'-3'_exoribonuclease_TrpH/YciV_(RNase_AM),_contains_PHP_domain YciV 40.0 0.125 0.875 0.0836949089384936 0.185881149460993 0.1347880291997433 0.1021862405224993 0 0 0 0 K20860 0.0057142857142857 0.0028490028490028 FHY1; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 184.0 2.0 1.0 2.0 0.666666666666667 S 2.0 1.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K20861 0.0028571428571428 0.0142450142450142 ybjI; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 106.0 5.0 2.0 2.0 0.625 S 1.0 7.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 8.0 0.125 0.875 0.0108185840792467 0.0261084055658427 0.0184634948225447 0.015289821486596 0 0 0 0 K20862 0.0171428571428571 0.0997150997150997 yigB; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 62.0 49.0 0.0 1.0 1.0 S 7.0 42.0 2.0 0.938775510204082 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 49.0 0.1428571428571428 0.8571428571428571 0.300372918606325 0.985275879347651 0.642824398976988 0.6849029607413261 0 0 0 0 K20866 0.0657142857142857 0.2022792022792023 yihX; glucose-1-phosphatase [EC:3.1.3.10] path:map00010,path:map01120 Glycolysis / Gluconeogenesis,Microbial metabolism in diverse environments 60.0 107.0 106.0 2.0 0.990740740740741 S 28.0 80.0 2.0 0.916666666666667 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 108.0 0.2592592592592592 0.7407407407407407 0.0374660589340848 0.220408792185996 0.1289374255600404 0.1829427332519111 0 0 0 0 K20881 0.0542857142857142 0.0569800569800569 yrfG; GMP/IMP 5'-nucleotidase [EC:3.1.3.-] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 145.0 36.0 32.0 2.0 0.9 S 20.0 20.0 4.0 0.775 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 40.0 0.5 0.5 0.808166994380872 0.654706561234455 0.7314367778076636 0.153460433146417 1 1 1 1 K20885 0.0885714285714285 0.131054131054131 K20885; beta-1,2-mannobiose phosphorylase / 1,2-beta-oligomannan phosphorylase [EC:2.4.1.339 2.4.1.340] 162.0 92.0 0.0 1.0 1.0 G 38.0 54.0 1.0 1.0 COG2152 Predicted_glycosyl_hydrolase,_GH43/DUF377_family 92.0 0.4130434782608695 0.5869565217391305 0.964757418484946 0.98257443228968 0.973665925387313 0.0178170138047339 1 1 1 1 K20890 0.0 0.0028490028490028 GUX; xylan alpha-glucuronosyltransferase [EC:2.4.1.-] 265.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG5597 N-acetylglucosaminyl_transferase Gnt1 1.0 0.0 1.0 0 0 0 0 K20895 0.0028571428571428 0.0028490028490028 ylmB; formylaminopyrimidine deformylase [EC:3.5.1.-] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 419.0 2.0 0.0 1.0 1.0 E 1.0 1.0 1.0 1.0 COG0624 Acetylornithine_deacetylase/Succinyl-diaminopimelate_desuccinylase_or_related_deacylase ArgE 2.0 0.5 0.5 0 0 0 0 K20896 0.0228571428571428 0.0199430199430199 TENA_E; formylaminopyrimidine deformylase / aminopyrimidine aminohydrolase [EC:3.5.1.- 3.5.99.-] path:map00730,path:map01100 Thiamine metabolism,Metabolic pathways 185.0 15.0 0.0 1.0 1.0 K 8.0 7.0 1.0 1.0 COG0819 Aminopyrimidine_aminohydrolase_TenA_(thiamine_salvage_pathway) TenA 15.0 0.5333333333333333 0.4666666666666667 0.0285984311150837 0.0839339637607883 0.056266197437936 0.0553355326457045 0 0 0 0 K20900 0.0 0.0113960113960113 dthD; D-threitol dehydrogenase (NAD+) [EC:1.1.1.403] 205.0 4.0 0.0 1.0 1.0 IQ 0.0 4.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 4.0 0.0 1.0 0.0224559153321968 0.0458009878886573 0.034128451610427 0.0233450725564605 0 0 0 0 K20901 0.0 0.0056980056980056 lerK; L-erythrulose 1-kinase [EC:2.7.1.209] 559.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG2376 Dihydroxyacetone_kinase DAK1 2.0 0.0 1.0 0 0 0 0 K20902 0.0 0.0056980056980056 derK; D-erythrulose 4-kinase [EC:2.7.1.210] 564.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG2376 Dihydroxyacetone_kinase DAK1 2.0 0.0 1.0 0 0 0 0 K20903 0.0 0.0142450142450142 hgdA; (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha [EC:4.2.1.167] 22.0 9.0 0.0 1.0 1.0 E 0.0 9.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 9.0 0.0 1.0 0.0117513655643482 0.0479272592183899 0.029839312391369 0.0361758936540417 0 0 0 0 K20904 0.0028571428571428 0.0113960113960113 hgdB; (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta [EC:4.2.1.167] 357.0 7.0 0.0 1.0 1.0 E 2.0 5.0 1.0 1.0 COG1775 Benzoyl-CoA_reductase/2-hydroxyglutaryl-CoA_dehydratase_subunit,_BcrC/BadD/HgdB HgdB 7.0 0.2857142857142857 0.7142857142857143 0.010230440268326 0.051841938746206 0.031036189507266 0.0416114984778799 0 0 0 0 K20905 0.0 0.0028490028490028 281.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0149 Triosephosphate_isomerase TpiA 1.0 0.0 1.0 0 0 0 0 K20906 0.0 0.0085470085470085 hcmA; 2-hydroxyisobutanoyl-CoA mutase large subunit [EC:5.4.99.64] 302.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG1884 Methylmalonyl-CoA_mutase,_N-terminal_domain/subunit Sbm 3.0 0.0 1.0 0 0 0 0 K20907 0.0 0.0113960113960113 hcmB; 2-hydroxyisobutanoyl-CoA mutase small subunit [EC:5.4.99.64] 103.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG2185 Methylmalonyl-CoA_mutase,_C-terminal_domain/subunit_(cobalamin-binding) Sbm 4.0 0.0 1.0 0.0008773375096341 0.0025500122940719 0.001713674901853 0.0016726747844378 0 0 0 0 K20918 0.0 0.0085470085470085 vpsT; LuxR family transcriptional regulator, positive regulator of biofilm formation path:map05111 Biofilm formation - Vibrio cholerae 194.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 4.0 0.0 1.0 1.41343238384656e-09 5.36144471598274e-08 2.7513939771836983e-08 5.220101477598084e-08 0 0 0 0 K20919 0.0 0.0085470085470085 vpsR, cpsR; sigma-54 dependent transcriptional regulator, positive regulator of biofilm formation path:map05111 Biofilm formation - Vibrio cholerae 265.0 2.0 1.0 2.0 0.666666666666667 T 0.0 3.0 1.0 1.0 COG2204 DNA-binding_transcriptional_response_regulator,_NtrC_family,_contains_REC,_AAA-type_ATPase,_and_a_Fis-type_DNA-binding_domains AtoC 3.0 0.0 1.0 0 0 0 0 K20920 0.0 0.0341880341880341 vpsM; polysaccharide biosynthesis protein VpsM path:map05111 Biofilm formation - Vibrio cholerae 313.0 9.0 6.0 2.0 0.75 S 0.0 12.0 2.0 0.833333333333333 COG5338 Uncharacterized_conserved_protein 12.0 0.0 1.0 0.0119410929113725 0.0617350319020542 0.0368380624067133 0.0497939389906817 0 0 0 0 K20921 0.0 0.0113960113960113 vpsD, epsF; polysaccharide biosynthesis protein VpsD path:map00543,path:map05111 Exopolysaccharide biosynthesis,Biofilm formation - Vibrio cholerae 370.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 4.0 0.0 1.0 0.0205915316101447 0.0404690547682403 0.0305302931891925 0.0198775231580956 0 0 0 0 K20922 0.0 0.0028490028490028 vpsI; polysaccharide biosynthesis protein VpsI path:map00543,path:map05111 Exopolysaccharide biosynthesis,Biofilm formation - Vibrio cholerae 347.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K20927 0.0 0.0142450142450142 mpdB; 2-methyl-1,2-propanediol dehydrogenase [EC:1.1.1.400] 471.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 5.0 0.0 1.0 0.027567327675713 0.125777190249144 0.0766722589624284 0.0982098625734309 0 0 0 0 K20928 0.0 0.0028490028490028 mpdC; 2-hydroxy-2-methylpropanal dehydrogenase [EC:1.2.1.98] 499.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 1.0 0.0 1.0 0 0 0 0 K20936 0.0028571428571428 0.0056980056980056 bdh; 1-butanol dehydrogenase (cytochrome c) [EC:1.1.2.9] 616.0 2.0 1.0 2.0 0.666666666666667 C 1.0 2.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K20937 0.0 0.0142450142450142 boh; 1-butanol dehydrogenase (quinone) [EC:1.1.5.11] 612.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG4993 Glucose_dehydrogenase,_PQQ-dependent Gcd 5.0 0.0 1.0 0.0529465988751336 0.0974330683916298 0.0751898336333816 0.0444864695164961 0 0 0 0 K20938 0.0285714285714285 0.0341880341880341 ladA; long-chain alkane monooxygenase [EC:1.14.14.28] 409.0 28.0 27.0 2.0 0.96551724137931 C 10.0 19.0 2.0 0.96551724137931 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 29.0 0.3448275862068966 0.6551724137931034 0.008866905834302 0.0295749717917266 0.0192209388130143 0.0207080659574246 0 0 0 0 K20940 0.0 0.0427350427350427 phzS; 5-methylphenazine-1-carboxylate 1-monooxygenase [EC:1.14.13.218] path:map00405,path:map01100,path:map01110 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 392.0 12.0 8.0 2.0 0.75 CH 0.0 16.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 16.0 0.0 1.0 0.0693181936715983 0.117071975584787 0.0931950846281926 0.0477537819131887 0 0 0 0 K20941 0.0 0.0085470085470085 graF; gamma-resorcylate decarboxylase [EC:4.1.1.103] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 272.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 4.0 0.0 1.0 0.0388416648753815 0.0856080487806084 0.0622248568279949 0.0467663839052269 0 0 0 0 K20942 0.0 0.0056980056980056 graA; resorcinol 4-hydroxylase (FADH2) [EC:1.14.14.27] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 380.0 2.0 0.0 1.0 1.0 I 0.0 2.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 2.0 0.0 1.0 0 0 0 0 K20943 0.0028571428571428 0.0028490028490028 E1.14.13.219; resorcinol 4-hydroxylase (NADPH) [EC:1.14.13.219] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 10.0 3.0 0.0 1.0 1.0 CH 2.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K20944 0.0028571428571428 0.0028490028490028 tsdB; resorcinol 4-hydroxylase (NADH) [EC:1.14.13.220] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 10.0 3.0 0.0 1.0 1.0 CH 2.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K20945 0.0 0.037037037037037 vpsU; tyrosine-protein phosphatase [EC:3.1.3.48] path:map05111 Biofilm formation - Vibrio cholerae 137.0 14.0 0.0 1.0 1.0 T 0.0 14.0 1.0 1.0 COG0394 Protein-tyrosine-phosphatase Wzb 14.0 0.0 1.0 0.0068514060994666 0.0233511755464529 0.0151012908229597 0.0164997694469863 0 0 0 0 K20946 0.0 0.0113960113960113 vpsE; polysaccharide biosynthesis protein VpsE path:map05111 Biofilm formation - Vibrio cholerae 278.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG2244 Membrane_protein_involved_in_the_export_of_O-antigen_and_teichoic_acid RfbX 4.0 0.0 1.0 0.0446037762542853 0.173274767077513 0.1089392716658991 0.1286709908232277 0 0 0 0 K20947 0.0 0.0028490028490028 vpsF; polysaccharide biosynthesis protein VpsF path:map05111 Biofilm formation - Vibrio cholerae 319.0 0.0 1.0 1.0 1.0 2ASTP 1.0 0.0 1.0 0 0 0 0 K20948 0.0028571428571428 0.0056980056980056 vpsJ; polysaccharide biosynthesis protein VpsJ path:map05111 Biofilm formation - Vibrio cholerae 286.0 3.0 0.0 1.0 1.0 O 1.0 2.0 1.0 1.0 COG1331 Uncharacterized_conserved_protein_YyaL,_SSP411_family,_contains_thoiredoxin_and_six-hairpin_glycosidase-like_domains YyaL 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K20949 0.0 0.0028490028490028 vpsP; polysaccharide biosynthesis protein VpsP path:map05111 Biofilm formation - Vibrio cholerae 254.0 0.0 1.0 1.0 1.0 2CAQ9 1.0 0.0 1.0 0 0 0 0 K20951 0.0 0.0085470085470085 bap1; extracellular matrix protein path:map05111 Biofilm formation - Vibrio cholerae 59.0 2.0 1.0 2.0 0.666666666666667 NU 0.0 3.0 1.0 1.0 COG1572 Serine_protease,_subtilase_family 3.0 0.0 1.0 0 0 0 0 K20952 0.0114285714285714 0.0484330484330484 rbmC; rugosity and biofilm structure modulator C path:map05111 Biofilm formation - Vibrio cholerae 58.0 18.0 14.0 4.0 0.666666666666667 S 4.0 23.0 5.0 0.666666666666667 COG1520 Outer_membrane_protein_assembly_factor_BamB,_contains_PQQ-like_beta-propeller_repeat PQQ 27.0 0.1481481481481481 0.8518518518518519 0.108482196163982 0.107065698275211 0.1077739472195964 0.001416497888771 0 0 0 0 K20954 0.0 0.0056980056980056 acgB; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 435.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 2.0 0.0 1.0 0 0 0 0 K20955 0.0 0.0113960113960113 cdgK; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 310.0 5.0 0.0 1.0 1.0 T 0.0 5.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 5.0 0.0 1.0 0.0161469398302609 0.0383639000947706 0.0272554199625157 0.0222169602645097 0 0 0 0 K20956 0.0 0.0085470085470085 cdgA; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 263.0 3.0 0.0 1.0 1.0 T 0.0 3.0 2.0 0.666666666666667 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 3.0 0.0 1.0 0 0 0 0 K20958 0.0028571428571428 0.0 cdgL; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 595.0 1.0 0.0 1.0 1.0 T 1.0 0.0 1.0 1.0 COG3322 Extracellular_(periplasmic)_sensor_domain_CHASE_(specificity_unknown) CHASE4 1.0 1.0 0.0 0 0 0 0 K20959 0.0 0.0056980056980056 cdgM; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 475.0 2.0 0.0 1.0 1.0 T 0.0 2.0 2.0 0.5 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 2.0 0.0 1.0 0 0 0 0 K20960 0.0 0.0085470085470085 K20960; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 158.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 3.0 0.0 1.0 0 0 0 0 K20961 0.0 0.0028490028490028 vpvC; diguanylate cyclase [EC:2.7.7.65] path:map05111 Biofilm formation - Vibrio cholerae 532.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 1.0 0.0 1.0 0 0 0 0 K20962 0.0 0.037037037037037 cdgC; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 146.0 19.0 18.0 3.0 0.904761904761905 T 0.0 21.0 9.0 0.333333333333333 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 21.0 0.0 1.0 0.177408151287188 0.0053970299748853 0.0914025906310366 0.1720111213123027 0 0 0 0 K20963 0.0 0.0028490028490028 acgA; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 589.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 1.0 0.0 1.0 0 0 0 0 K20964 0.0 0.0113960113960113 cdpA; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 584.0 5.0 0.0 1.0 1.0 T 0.0 5.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 5.0 0.0 1.0 0.0172861330508838 0.0442616776397874 0.0307739053453356 0.0269755445889036 0 0 0 0 K20965 0.0 0.0056980056980056 rocS; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map05111 Biofilm formation - Vibrio cholerae 342.0 2.0 0.0 1.0 1.0 T 0.0 2.0 1.0 1.0 COG5001 Cyclic_di-GMP_metabolism_protein,_combines_GGDEF_and_EAL_domains_with_a_6TM_membrane_domain 2.0 0.0 1.0 0 0 0 0 K20967 0.0114285714285714 0.0512820512820512 MOCS1; GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase [EC:4.1.99.22 4.6.1.17] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 262.0 22.0 0.0 1.0 1.0 H 4.0 18.0 1.0 1.0 COG2896 GTP_3',8-cyclase_(molybdenum_cofactor_biosynthesis_protein_MoaA) MoaA 22.0 0.1818181818181818 0.8181818181818182 0.364014966233415 0.618638636046436 0.4913268011399255 0.254623669813021 0 0 0 0 K20968 0.0 0.0113960113960113 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA path:map02025 Biofilm formation - Pseudomonas aeruginosa 222.0 4.0 0.0 1.0 1.0 K 0.0 4.0 2.0 0.75 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 4.0 0.0 1.0 0.0085303619806382 0.0178122374936696 0.0131712997371539 0.0092818755130314 0 0 0 0 K20971 0.0 0.0854700854700854 ladS; two-component system, sensor histidine kinase LadS path:map02025 Biofilm formation - Pseudomonas aeruginosa 69.0 31.0 26.0 3.0 0.837837837837838 T 0.0 37.0 12.0 0.324324324324324 COG0642 Signal_transduction_histidine_kinase BaeS 37.0 0.0 1.0 0.0083650498815996 0.0878856038490399 0.0481253268653197 0.0795205539674403 0 0 0 0 K20972 0.0 0.0199430199430199 retS; two-component system, sensor histidine kinase RetS path:map02025 Biofilm formation - Pseudomonas aeruginosa 1.0 6.0 5.0 2.0 0.857142857142857 T 0.0 7.0 4.0 0.571428571428571 COG0642 Signal_transduction_histidine_kinase BaeS 7.0 0.0 1.0 0.887438557663468 0.083368325925078 0.485403441794273 0.80407023173839 0 0 1 1 K20973 0.0 0.0284900284900284 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3] path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 221.0 13.0 0.0 1.0 1.0 T 0.0 13.0 2.0 0.769230769230769 COG0642 Signal_transduction_histidine_kinase BaeS 13.0 0.0 1.0 0.009667696769815 0.0272363795565886 0.0184520381632018 0.0175686827867736 0 0 0 0 K20974 0.0085714285714285 0.1054131054131054 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 199.0 55.0 54.0 3.0 0.964912280701754 T 3.0 54.0 4.0 0.719298245614035 COG0642 Signal_transduction_histidine_kinase BaeS 57.0 0.0526315789473684 0.9473684210526316 0.0084008770513136 0.0206764123272711 0.0145386446892923 0.0122755352759575 0 0 0 0 K20975 0.0 0.0284900284900284 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3] path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 625.0 9.0 8.0 2.0 0.9 T 0.0 10.0 3.0 0.6 COG0642 Signal_transduction_histidine_kinase BaeS 10.0 0.0 1.0 0.0062204425785375 0.0114995494287195 0.0088599960036285 0.005279106850182 0 0 0 0 K20976 0.0028571428571428 0.0569800569800569 hptB; histidine phosphotransfer protein HptB path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 49.0 28.0 0.0 1.0 1.0 T 1.0 27.0 4.0 0.642857142857143 COG2198 HPt_(histidine-containing_phosphotransfer)_domain HPtr 28.0 0.0357142857142857 0.9642857142857144 0.0043716048204245 0.0265671589135236 0.015469381866974 0.0221955540930991 0 0 0 0 K20977 0.0 0.0541310541310541 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 151.0 30.0 29.0 2.0 0.967741935483871 T 0.0 31.0 8.0 0.258064516129032 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 31.0 0.0 1.0 0.0024781896065693 0.0134475781008768 0.007962883853723 0.0109693884943075 0 0 0 0 K20978 0.0 0.0797720797720797 hsbA; HptB-dependent secretion and biofilm anti anti-sigma factor path:map02020,path:map02025 Two-component system,Biofilm formation - Pseudomonas aeruginosa 46.0 44.0 0.0 1.0 1.0 T 0.0 44.0 1.0 1.0 COG1366 Anti-anti-sigma_regulatory_factor_(antagonist_of_anti-sigma_factor) SpoIIAA 44.0 0.0 1.0 0.0062961292106729 0.0215340407692933 0.0139150849899831 0.0152379115586204 0 0 0 0 K20986 0.0 0.0028490028490028 NUDX1; geranyl diphosphate phosphohydrolase [EC:3.6.1.68] path:map00902,path:map01110 Monoterpenoid biosynthesis,Biosynthesis of secondary metabolites 140.0 1.0 0.0 1.0 1.0 F 0.0 1.0 1.0 1.0 COG1051 ADP-ribose_pyrophosphatase_YjhB,_NUDIX_family YjhB 1.0 0.0 1.0 0 0 0 0 K20987 0.0 0.0199430199430199 pslD; polysaccharide biosynthesis/export protein PslD path:map02025 Biofilm formation - Pseudomonas aeruginosa 216.0 6.0 5.0 2.0 0.857142857142857 M 0.0 7.0 1.0 1.0 COG1596 Periplasmic_protein_Wza_involved_in_polysaccharide_export,_contains_SLBB_domain_of_the_beta-grasp_fold Wza 7.0 0.0 1.0 0.105409715225139 0.187648312046306 0.1465290136357225 0.0822385968211669 0 0 0 0 K20988 0.0 0.0284900284900284 vpsN; polysaccharide biosynthesis/export protein VpsN path:map05111 Biofilm formation - Vibrio cholerae 169.0 10.0 0.0 1.0 1.0 M 0.0 10.0 1.0 1.0 COG1596 Periplasmic_protein_Wza_involved_in_polysaccharide_export,_contains_SLBB_domain_of_the_beta-grasp_fold Wza 10.0 0.0 1.0 0.021783442886606 0.0520010056893593 0.0368922242879826 0.0302175628027533 0 0 0 0 K20989 0.0885714285714285 0.0085470085470085 DUR3; urea-proton symporter 74.0 47.0 36.0 2.0 0.810344827586207 T 53.0 3.0 2.0 0.879310344827586 COG0589 Nucleotide-binding_universal_stress_protein,__UspA_family UspA 56.0 0.9464285714285714 0.0535714285714285 0.0032840321740487 0.0050145086676398 0.0041492704208442 0.0017304764935911 0 0 0 0 K20993 0.0 0.0028490028490028 estP; pyrethroid hydrolase [EC:3.1.1.88] 538.0 0.0 1.0 1.0 1.0 COG1700 Predicted_anti-virus_defense_system_component_AQ645,_contains_DUF2357_and__PD-(D/E)xK_nuclease_domains AQ645 1.0 0.0 1.0 0 0 0 0 K20994 0.0028571428571428 0.0 NOTCH2; Notch 2 path:map01522,path:map04320,path:map04330,path:map04658,path:map04919,path:map05165,path:map05200,path:map05206,path:map05207,path:map05224 Endocrine resistance,Dorso-ventral axis formation,Notch signaling pathway,Th1 and Th2 cell differentiation,Thyroid hormone signaling pathway,Human papillomavirus infection,Pathways in cancer,MicroRNAs in cancer,Chemical carcinogenesis - receptor activation,Breast cancer 442.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG1217 1.0 1.0 0.0 0 0 0 0 K20997 0.0 0.037037037037037 pslA; polysaccharide biosynthesis protein PslA path:map00543,path:map02025 Exopolysaccharide biosynthesis,Biofilm formation - Pseudomonas aeruginosa 400.0 13.0 0.0 1.0 1.0 M 0.0 13.0 2.0 0.615384615384615 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 13.0 0.0 1.0 0.0205960144140751 0.0431487738877496 0.0318723941509123 0.0225527594736744 0 0 0 0 K20998 0.0 0.0142450142450142 pslE; polysaccharide biosynthesis protein PslE path:map02025 Biofilm formation - Pseudomonas aeruginosa 230.0 2.0 0.0 3.0 0.4 D 0.0 5.0 2.0 0.6 COG3206 Exopolysaccharide_export_protein/domain_GumC/Wzc1 GumC 5.0 0.0 1.0 0.117253421684646 0.17750628007765 0.147379850881148 0.060252858393004 0 0 0 0 K20999 0.0 0.0056980056980056 pslF; polysaccharide biosynthesis protein PslF path:map00543,path:map02025 Exopolysaccharide biosynthesis,Biofilm formation - Pseudomonas aeruginosa 337.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 2.0 0.0 1.0 0 0 0 0 K21000 0.0 0.0712250712250712 pslG; polysaccharide biosynthesis protein PslG path:map02025 Biofilm formation - Pseudomonas aeruginosa 87.0 32.0 30.0 3.0 0.914285714285714 G 0.0 35.0 6.0 0.371428571428571 COG3664 Beta-xylosidase XynB 35.0 0.0 1.0 0.160389215038702 0.567342100138334 0.3638656575885179 0.406952885099632 0 0 0 0 K21001 0.0057142857142857 0.0199430199430199 pslH; polysaccharide biosynthesis protein PslH path:map00543,path:map02025 Exopolysaccharide biosynthesis,Biofilm formation - Pseudomonas aeruginosa 172.0 10.0 0.0 1.0 1.0 M 2.0 8.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 10.0 0.2 0.8 0.0420005481034836 0.0734750048302231 0.0577377764668533 0.0314744567267394 0 0 0 0 K21002 0.0 0.0028490028490028 pslI; polysaccharide biosynthesis protein PslI path:map00543,path:map02025 Exopolysaccharide biosynthesis,Biofilm formation - Pseudomonas aeruginosa 388.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 1.0 0.0 1.0 0 0 0 0 K21003 0.0 0.0085470085470085 pslJ; polysaccharide biosynthesis protein PslJ path:map02025 Biofilm formation - Pseudomonas aeruginosa 332.0 4.0 0.0 1.0 1.0 M 0.0 4.0 3.0 0.5 COG3307 O-antigen_ligase RfaL 4.0 0.0 1.0 5.74585644513816e-12 9.880899434176107e-12 7.813377939657134e-12 4.135042989037948e-12 0 0 0 0 K21004 0.0 0.0142450142450142 pslK; polysaccharide biosynthesis protein PslK path:map02025 Biofilm formation - Pseudomonas aeruginosa 282.0 4.0 3.0 2.0 0.8 M 0.0 5.0 1.0 1.0 COG0728 Lipid_II_flippase_MurJ/MviN_(peptidoglycan_biosynthesis) MurJ 5.0 0.0 1.0 0.108447239858711 0.207161752475238 0.1578044961669745 0.0987145126165269 0 0 0 0 K21005 0.0 0.0056980056980056 pslL; polysaccharide biosynthesis protein PslL path:map02025 Biofilm formation - Pseudomonas aeruginosa 268.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG3594 Fucose_4-O-acetylase_or_related_acetyltransferase NolL 2.0 0.0 1.0 0 0 0 0 K21006 0.0 0.0 pelA; polysaccharide biosynthesis protein PelA path:map02025 Biofilm formation - Pseudomonas aeruginosa 21.0 12.0 3.0 0.67741935483871 S 0.0 0.0 3.0 0.774193548387097 COG3868 Predicted_glycosyl_hydrolase,_GH114_family 0.0 0 0 0 0 K21007 0.0 0.0398860398860398 pelB; polysaccharide biosynthesis protein PelB path:map02025 Biofilm formation - Pseudomonas aeruginosa 73.0 5.0 1.0 4.0 0.454545454545455 S 0.0 15.0 3.0 0.466666666666667 COG0457 Tetratricopeptide_(TPR)_repeat TPR 15.0 0.0 1.0 0.0345280714647916 0.0904923954232236 0.0625102334440076 0.055964323958432 0 0 0 0 K21008 0.0 0.0427350427350427 pelC; polysaccharide biosynthesis protein PelC path:map02025 Biofilm formation - Pseudomonas aeruginosa 123.0 12.0 7.0 2.0 0.705882352941176 S 0.0 17.0 2.0 0.764705882352941 COG5616 TolB_amino-terminal_domain_(function_unknown) TolBN 17.0 0.0 1.0 0.0213898666797777 0.0274700720466207 0.0244299693631992 0.0060802053668429 0 0 0 0 K21009 0.0 0.0769230769230769 pelD; polysaccharide biosynthesis protein PelD path:map02025 Biofilm formation - Pseudomonas aeruginosa 83.0 23.0 19.0 3.0 0.741935483870968 T 0.0 33.0 8.0 0.575757575757576 COG2203 GAF_domain GAF 33.0 0.0 1.0 0.004299666199507 0.0337392484772022 0.0190194573383546 0.0294395822776952 0 0 0 0 K21010 0.0 0.0541310541310541 pelE; polysaccharide biosynthesis protein PelE path:map02025 Biofilm formation - Pseudomonas aeruginosa 24.0 15.0 11.0 4.0 0.6 L 0.0 26.0 7.0 0.5 COG4783 Outer_membrane_protein_chaperone/metalloprotease_BepA/YfgC,_contains_M48_and_TPR_domains BepA 26.0 0.0 1.0 0.0475739839886968 0.104329650191789 0.0759518170902429 0.0567556662030922 0 0 0 0 K21011 0.0228571428571428 0.094017094017094 pelF; polysaccharide biosynthesis protein PelF path:map02025 Biofilm formation - Pseudomonas aeruginosa 197.0 50.0 0.0 1.0 1.0 M 11.0 39.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 50.0 0.22 0.78 0.751785715893722 0.95031576059913 0.8510507382464261 0.198530044705408 1 1 1 1 K21012 0.0 0.0797720797720797 pelG; polysaccharide biosynthesis protein PelG path:map02025 Biofilm formation - Pseudomonas aeruginosa 182.0 18.0 11.0 3.0 0.642857142857143 S 0.0 30.0 5.0 0.6 COG4267 Uncharacterized_membrane_protein 30.0 0.0 1.0 0.0483678241803281 0.31348725748879 0.180927540834559 0.2651194333084619 0 0 0 0 K21014 0.0 0.0113960113960113 stf0; trehalose 2-sulfotransferase [EC:2.8.2.37] 150.0 4.0 0.0 1.0 1.0 S 0.0 4.0 1.0 1.0 COG4424 LPS_sulfotransferase_NodH LpsS 4.0 0.0 1.0 0.0773085856484066 0.168226023371255 0.1227673045098308 0.0909174377228484 0 0 0 0 K21019 0.0 0.0199430199430199 sadC; diguanylate cyclase [EC:2.7.7.65] path:map02025 Biofilm formation - Pseudomonas aeruginosa 341.0 10.0 0.0 1.0 1.0 T 0.0 10.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 10.0 0.0 1.0 0.0029716871575716 0.0066544015702693 0.0048130443639204 0.0036827144126977 0 0 0 0 K21020 0.0 0.037037037037037 siaD; diguanylate cyclase [EC:2.7.7.65] path:map02025 Biofilm formation - Pseudomonas aeruginosa 223.0 15.0 0.0 1.0 1.0 T 0.0 15.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 15.0 0.0 1.0 0.0174997011196999 0.13724477383803 0.0773722374788649 0.1197450727183301 0 0 0 0 K21021 0.0 0.0227920227920227 tpbB; diguanylate cyclase [EC:2.7.7.65] path:map02025 Biofilm formation - Pseudomonas aeruginosa 253.0 9.0 0.0 1.0 1.0 T 0.0 9.0 4.0 0.666666666666667 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 9.0 0.0 1.0 0.0221803637634513 0.0589468951037126 0.0405636294335819 0.0367665313402612 0 0 0 0 K21022 0.0028571428571428 0.0284900284900284 roeA; diguanylate cyclase [EC:2.7.7.65] path:map02025 Biofilm formation - Pseudomonas aeruginosa 167.0 13.0 0.0 1.0 1.0 T 1.0 12.0 2.0 0.923076923076923 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 13.0 0.0769230769230769 0.9230769230769232 0.0065247456372094 0.0940338609775088 0.0502793033073591 0.0875091153402994 0 0 0 0 K21023 0.0 0.1196581196581196 mucR; diguanylate cyclase [EC:2.7.7.65] path:map02025 Biofilm formation - Pseudomonas aeruginosa 251.0 65.0 63.0 2.0 0.970149253731343 T 0.0 66.0 5.0 0.671641791044776 COG5001 Cyclic_di-GMP_metabolism_protein,_combines_GGDEF_and_EAL_domains_with_a_6TM_membrane_domain 66.0 0.0 1.0 0.0025530778912136 0.0991898347616815 0.0508714563264475 0.0966367568704679 0 0 0 0 K21024 0.0 0.017094017094017 bifA; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map02025 Biofilm formation - Pseudomonas aeruginosa 395.0 6.0 0.0 1.0 1.0 T 0.0 6.0 3.0 0.5 COG5001 Cyclic_di-GMP_metabolism_protein,_combines_GGDEF_and_EAL_domains_with_a_6TM_membrane_domain 6.0 0.0 1.0 0.0137612743045273 0.0489517041372146 0.0313564892208709 0.0351904298326873 0 0 0 0 K21025 0.0 0.0598290598290598 fimX; multidomain signaling protein FimX path:map02025 Biofilm formation - Pseudomonas aeruginosa 43.0 25.0 0.0 1.0 1.0 T 0.0 25.0 6.0 0.4 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 25.0 0.0 1.0 0.0031926640983492 0.0057670708040362 0.0044798674511927 0.0025744067056869 0 0 0 0 K21028 0.0628571428571428 0.0797720797720797 ynjE; molybdopterin synthase sulfurtransferase [EC:2.8.1.11] path:map04122 Sulfur relay system 58.0 49.0 40.0 2.0 0.844827586206896 P 25.0 33.0 3.0 0.724137931034483 COG2897 3-mercaptopyruvate_sulfurtransferase_SseA,_contains_two_rhodanese_domains SseA 58.0 0.4310344827586206 0.5689655172413793 0.125565142445937 0.883698703508868 0.5046319229774026 0.7581335610629311 0 0 0 0 K21029 0.6885714285714286 0.5413105413105413 moeB; molybdopterin-synthase adenylyltransferase [EC:2.7.7.80] path:map04122 Sulfur relay system 65.0 543.0 523.0 4.0 0.961061946902655 H 318.0 249.0 4.0 0.971781305114638 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 567.0 0.5608465608465608 0.4391534391534391 0.303141424294296 0.736109972595981 0.5196256984451385 0.4329685483016849 0 0 0 0 K21030 0.0142857142857142 0.0284900284900284 tarI; D-ribitol-5-phosphate cytidylyltransferase [EC:2.7.7.40] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 201.0 18.0 0.0 1.0 1.0 I 7.0 11.0 3.0 0.833333333333333 COG1211 2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase IspD 18.0 0.3888888888888889 0.6111111111111112 0.0065920590902374 0.0178326934633406 0.0122123762767889 0.0112406343731031 0 0 0 0 K21034 0.0 0.0113960113960113 virH2, CYP104; cytochrome P450 family 104 387.0 3.0 1.0 3.0 0.5 Q 0.0 5.0 2.0 0.666666666666667 COG2124 Cytochrome_P450 CypX 5.0 0.0 1.0 0.0056974057976193 0.0175516349341002 0.0116245203658597 0.0118542291364809 0 0 0 0 K21036 0.0 0.0056980056980056 vldW; validamycin A dioxygenase [EC:1.14.11.52] path:map00525,path:map01110 Acarbose and validamycin biosynthesis,Biosynthesis of secondary metabolites 307.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG3491 Isopenicillin_N_synthase_and_related_dioxygenases PcbC 2.0 0.0 1.0 0 0 0 0 K21039 0.0 0.0028490028490028 int; Escherichia phage integrase [EC:2.7.7.- 3.1.-.-] 398.0 1.0 0.0 1.0 1.0 L 0.0 1.0 1.0 1.0 COG0582 Integrase/recombinase,_includes_phage_integrase FimB 1.0 0.0 1.0 0 0 0 0 K21053 0.0171428571428571 0.1282051282051282 ade; adenine deaminase [EC:3.5.4.2] path:map00230,path:map01100,path:map01232 Purine metabolism,Metabolic pathways,Nucleotide metabolism 237.0 59.0 0.0 1.0 1.0 F 6.0 53.0 2.0 0.983050847457627 COG1816 Adenosine_deaminase Add 59.0 0.1016949152542373 0.8983050847457628 0.387174216593743 0.815167131072702 0.6011706738332225 0.427992914478959 0 0 0 0 K21054 0.0 0.017094017094017 eryB; D-erythritol 1-phosphate dehydrogenase [EC:1.1.1.402] 496.0 7.0 0.0 1.0 1.0 C 0.0 7.0 1.0 1.0 COG0578 Glycerol-3-phosphate_dehydrogenase GlpA 7.0 0.0 1.0 0.058087354033837 0.0670209016308481 0.0625541278323425 0.0089335475970111 0 0 0 0 K21055 0.0 0.0256410256410256 E3.1.3.103; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase [EC:3.1.3.103] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 155.0 6.0 3.0 2.0 0.666666666666667 S 0.0 9.0 2.0 0.666666666666667 COG1778 3-deoxy-D-manno-octulosonate_8-phosphate_phosphatase_KdsC_and_related_HAD_superfamily_phosphatases KdsC 9.0 0.0 1.0 0.0739828458644875 0.176289492412144 0.1251361691383157 0.1023066465476565 0 0 0 0 K21056 0.0171428571428571 0.0 E2.7.1.212; alpha-D-ribose-1-phosphate 5-kinase (ADP) [EC:2.7.1.212] 292.0 6.0 0.0 1.0 1.0 G 6.0 0.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 6.0 1.0 0.0 2.18185533599868e-21 3.98838917880696e-13 1.994194600312757e-13 3.9883891569884074e-13 0 0 0 0 K21057 0.0628571428571428 0.0056980056980056 E2.7.1.213; cytidine kinase [EC:2.7.1.213] path:map00240,path:map01100,path:map01232 Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 255.0 25.0 0.0 1.0 1.0 G 23.0 2.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 25.0 0.92 0.08 0.65161950586517 0.987948779776082 0.8197841428206261 0.3363292739109119 0 0 0 1 K21058 0.0 0.0113960113960113 bciC; chlorophyllide a hydrolase [EC:3.1.1.100] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 192.0 0.0 4.0 1.0 1.0 29IX7 4.0 0.0 1.0 0 0 0 0 K21059 0.0 0.0056980056980056 fadD29; 4-hydroxyphenylalkanoate adenylyltransferase [EC:6.2.1.51] 567.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 2.0 0.0 1.0 0 0 0 0 K21060 0.0 0.0028490028490028 lhpB; D-hydroxyproline dehydrogenase [EC:1.5.99.-] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 436.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 1.0 0.0 1.0 0 0 0 0 K21061 0.0 0.0227920227920227 lhpB; D-hydroxyproline dehydrogenase subunit beta [EC:1.5.99.-] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 363.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 8.0 0.0 1.0 0.0788551868953093 0.199472729011833 0.1391639579535711 0.1206175421165236 0 0 0 0 K21062 0.0 0.1139601139601139 lhpC; 1-pyrroline-4-hydroxy-2-carboxylate deaminase [EC:3.5.4.22] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 258.0 31.0 22.0 3.0 0.75609756097561 EM 0.0 41.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 41.0 0.0 1.0 0.0391573468962953 0.405248224117059 0.2222027855066771 0.3660908772207637 0 0 0 0 K21063 0.0085714285714285 0.037037037037037 K21063; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 129.0 16.0 0.0 1.0 1.0 S 3.0 13.0 1.0 1.0 COG1011 FMN_and_5-amino-6-(5-phospho-D-ribitylamino)uracil_phosphatase_YigB,_HAD_superfamily_(riboflavin_biosynthesis) YigB 16.0 0.1875 0.8125 0.0167719835913481 0.0755253434760338 0.0461486635336909 0.0587533598846857 0 0 0 0 K21064 0.0028571428571428 0.0569800569800569 ycsE, yitU, ywtE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104] path:map00740,path:map01100,path:map01110,path:map01240 Riboflavin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 137.0 29.0 28.0 3.0 0.935483870967742 S 1.0 30.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 31.0 0.032258064516129 0.967741935483871 0.0028696127428975 0.0070537902494469 0.0049617014961721 0.0041841775065493 0 0 0 0 K21065 0.0028571428571428 0.0484330484330484 E3.2.1.197; beta-1,2-mannosidase [EC:3.2.1.197] 260.0 18.0 0.0 1.0 1.0 G 1.0 17.0 1.0 1.0 COG2152 Predicted_glycosyl_hydrolase,_GH43/DUF377_family 18.0 0.0555555555555555 0.9444444444444444 0.54737364858784 0.0571523298897088 0.3022629892387743 0.4902213186981312 0 0 0 1 K21071 0.0914285714285714 0.4985754985754986 pfk, pfp; ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90] path:map00010,path:map00030,path:map00051,path:map00052,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Galactose metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 142.0 146.0 68.0 3.0 0.494915254237288 G 39.0 256.0 1.0 1.0 COG0205 6-phosphofructokinase PfkA 295.0 0.1322033898305084 0.8677966101694915 0.809458365452732 0.655951995358592 0.732705180405662 0.1535063700941399 1 1 1 1 K21084 0.0 0.0484330484330484 yegE; diguanylate cyclase [EC:2.7.7.65] path:map02026 Biofilm formation - Escherichia coli 214.0 19.0 0.0 1.0 1.0 T 0.0 19.0 11.0 0.421052631578947 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 19.0 0.0 1.0 0.0067359353273665 0.0119336270992051 0.0093347812132857 0.0051976917718385 0 0 0 0 K21085 0.0 0.0256410256410256 yedQ; diguanylate cyclase [EC:2.7.7.65] path:map02026 Biofilm formation - Escherichia coli 113.0 10.0 0.0 1.0 1.0 T 0.0 10.0 1.0 1.0 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 10.0 0.0 1.0 0.011824167555981 0.0150811434251706 0.0134526554905758 0.0032569758691895 0 0 0 0 K21086 0.0 0.0085470085470085 yhjH; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map02026 Biofilm formation - Escherichia coli 173.0 3.0 0.0 1.0 1.0 T 0.0 3.0 1.0 1.0 COG2200 EAL_domain,_c-di-GMP-specific_phosphodiesterase_class_I_(or_its_enzymatically_inactive_variant) EAL 3.0 0.0 1.0 0 0 0 0 K21087 0.0 0.0113960113960113 ycgR; flagellar brake protein path:map02026 Biofilm formation - Escherichia coli 53.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG5581 Cyclic_di-GMP-binding_flagellar_brake_protein_FlgZ/YcgR,_contains_PilZNR(YcgR)_and_PilZ_domains YcgR 4.0 0.0 1.0 0.0502936671319382 0.0858665685551039 0.068080117843521 0.0355729014231657 0 0 0 0 K21088 0.0 0.0227920227920227 ydaM; diguanylate cyclase [EC:2.7.7.65] path:map02026 Biofilm formation - Escherichia coli 204.0 9.0 0.0 1.0 1.0 T 0.0 9.0 2.0 0.888888888888889 COG2199 GGDEF_domain,_diguanylate_cyclase_(c-di-GMP_synthetase)_or_its_enzymatically_inactive_variants GGDEF 9.0 0.0 1.0 0.0232160773967583 0.0569784879681105 0.0400972826824344 0.0337624105713522 0 0 0 0 K21089 0.0 0.0142450142450142 mlrA; MerR family transcriptional regulator, activator of the csg genes path:map02026 Biofilm formation - Escherichia coli 182.0 4.0 2.0 2.0 0.666666666666667 K 0.0 6.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 6.0 0.0 1.0 0.0382840861215194 0.0834960353098447 0.060890060715682 0.0452119491883253 0 0 0 0 K21090 0.0 0.0028490028490028 adrB; c-di-GMP phosphodiesterase [EC:3.1.4.52] path:map02026 Biofilm formation - Escherichia coli 532.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG2200 EAL_domain,_c-di-GMP-specific_phosphodiesterase_class_I_(or_its_enzymatically_inactive_variant) EAL 1.0 0.0 1.0 0 0 0 0 K21103 0.0 0.0028490028490028 phzM; phenazine-1-carboxylate N-methyltransferase [EC:2.1.1.327] path:map00405,path:map01100,path:map01110 Phenazine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 338.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG2519 tRNA_A58_N-methylase_Trm61 Gcd14 1.0 0.0 1.0 0 0 0 0 K21104 0.0 0.0341880341880341 E3.1.1.101; poly(ethylene terephthalate) hydrolase [EC:3.1.1.101] path:map00624,path:map01100,path:map01120 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments 234.0 9.0 2.0 4.0 0.473684210526316 S 0.0 19.0 3.0 0.368421052631579 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 19.0 0.0 1.0 0.0083167751826561 0.0167352220505382 0.0125259986165971 0.008418446867882 0 0 0 0 K21105 0.0028571428571428 0.037037037037037 E3.1.1.102; mono(ethylene terephthalate) hydrolase [EC:3.1.1.102] path:map00624,path:map01100,path:map01120 Polycyclic aromatic hydrocarbon degradation,Metabolic pathways,Microbial metabolism in diverse environments 166.0 8.0 2.0 3.0 0.421052631578947 S 1.0 18.0 5.0 0.315789473684211 COG0627 S-formylglutathione_hydrolase_FrmB FrmB 19.0 0.0526315789473684 0.9473684210526316 0.0149461516614907 0.0304053327409154 0.022675742201203 0.0154591810794246 0 0 0 0 K21113 0.0 0.0028490028490028 CYP106; cytochrome P450 family 106 409.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K21114 0.0 0.0028490028490028 CYP106A2; steroid 15beta-monooxygenase [EC:1.14.15.8] 409.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K21115 0.0 0.0028490028490028 CYP107B1; cytochrome P450 family 107 subfamily B1 413.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K21117 0.0 0.0028490028490028 CYP114; cytochrome P450 family 114 410.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K21119 0.0 0.0056980056980056 CYP130; cytochrome P450 family 130 255.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K21134 0.0 0.0113960113960113 triC; multidrug efflux pump 1016.0 7.0 0.0 1.0 1.0 V 0.0 7.0 1.0 1.0 COG0841 Multidrug_efflux_pump_subunit_AcrB AcrB 7.0 0.0 1.0 0.0062695425666046 6.815508106397e-06 0.0031381790373554 0.0062627270584982 0 0 0 0 K21135 0.0 0.0142450142450142 mexM; membrane fusion protein, multidrug efflux system 396.0 6.0 0.0 1.0 1.0 M 0.0 6.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 6.0 0.0 1.0 0.008176746681059 0.0128188720380449 0.0104978093595519 0.0046421253569859 0 0 0 0 K21136 0.0 0.0199430199430199 triA; membrane fusion protein, multidrug efflux system 343.0 9.0 0.0 1.0 1.0 M 0.0 9.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 9.0 0.0 1.0 0.0235810646764183 0.0514872229854973 0.0375341438309578 0.027906158309079 0 0 0 0 K21137 0.0 0.0113960113960113 triB; membrane fusion protein, multidrug efflux system 312.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG0845 Multidrug_efflux_pump_subunit_AcrA_(membrane-fusion_protein) AcrA 4.0 0.0 1.0 0.069240811657824 0.139644368604525 0.1044425901311745 0.070403556946701 0 0 0 0 K21138 0.0085714285714285 0.0085470085470085 HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [EC:3.1.7.2] path:map00230,path:map01100 Purine metabolism,Metabolic pathways 144.0 4.0 2.0 2.0 0.666666666666667 KT 3.0 3.0 1.0 1.0 COG0317 (p)ppGpp_synthase/hydrolase,_HD_superfamily SpoT 6.0 0.5 0.5 0.041253638717611 0.0857230265828859 0.0634883326502484 0.0444693878652749 0 0 0 0 K21140 0.0942857142857142 0.1282051282051282 mec; [CysO sulfur-carrier protein]-S-L-cysteine hydrolase [EC:3.13.1.6] path:map04122 Sulfur relay system 68.0 68.0 55.0 2.0 0.839506172839506 S 33.0 48.0 1.0 1.0 COG1310 Proteasome_lid_subunit_RPN8/RPN11,_contains_Jab1/MPN_domain_metalloenzyme_(JAMM)_motif Rri1 81.0 0.4074074074074074 0.5925925925925926 0.9625990727226 0.537907312380183 0.7502531925513916 0.424691760342417 1 1 1 1 K21142 0.0 0.0 moaX; MoaE-MoaD fusion protein [EC:2.8.1.12] path:map00790,path:map01100,path:map01240,path:map04122 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors,Sulfur relay system 147.0 0.0 1.0 1.0 H 0.0 0.0 2.0 0.700680272108844 COG0314 Molybdopterin_synthase_catalytic_subunit_MoaE MoaE 0.0 0 0 0 0 K21146 0.0 0.0028490028490028 CYP105A1; vitamin D 1,25-hydroxylase [EC:1.14.15.22] path:map00100,path:map01100,path:map01110 Steroid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 389.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K21147 0.0685714285714285 0.3447293447293447 moeZR, moeBR; sulfur-carrier protein adenylyltransferase/sulfurtransferase [EC:2.7.7.80 2.7.7.- 2.8.1.11 2.8.1.-] path:map04122 Sulfur relay system 144.0 93.0 16.0 4.0 0.513812154696133 H 30.0 151.0 6.0 0.856353591160221 COG0476 Molybdopterin_or_thiamine_biosynthesis_adenylyltransferase ThiF 181.0 0.1657458563535911 0.8342541436464088 0.0025240398851881 0.468974597021424 0.235749318453306 0.4664505571362359 0 0 0 0 K21148 0.0085714285714285 0.0712250712250712 cysM; [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase [EC:2.5.1.113] path:map04122 Sulfur relay system 292.0 28.0 0.0 1.0 1.0 E 3.0 25.0 1.0 1.0 COG0031 Cysteine_synthase CysK 28.0 0.1071428571428571 0.8928571428571429 0.0063710132007077 0.844297147875708 0.4253340805382078 0.8379261346750003 0 0 0 0 K21153 0.0028571428571428 0.0028490028490028 salL; adenosyl-chloride synthase [EC:2.5.1.94] 260.0 2.0 0.0 1.0 1.0 S 1.0 1.0 1.0 1.0 COG1912 Stereoselective_(R,S)-S-adenosylmethionine_hydrolase_(adenosine-forming) 2.0 0.5 0.5 0 0 0 0 K21159 0.0057142857142857 0.0398860398860398 sgcF, ncsF2, kedF; epoxide hydrolase path:map01059 Biosynthesis of enediyne antibiotics 333.0 21.0 19.0 3.0 0.84 S 2.0 23.0 2.0 0.84 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 25.0 0.08 0.92 0.0054437070721788 0.022078881058846 0.0137612940655124 0.0166351739866672 0 0 0 0 K21160 0.0 0.0085470085470085 sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 325.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 28IKZ 3.0 0.0 1.0 0 0 0 0 K21161 0.0 0.017094017094017 sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 316.0 6.0 0.0 1.0 1.0 S 0.0 6.0 1.0 1.0 28IKZ 6.0 0.0 1.0 0.0762224307271783 0.177834707677742 0.1270285692024601 0.1016122769505637 0 0 0 0 K21162 0.0 0.017094017094017 sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 230.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG4658 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfD_subunit RnfD 11.0 0.0 1.0 0.0480265250650671 0.0739585973909073 0.0609925612279872 0.0259320723258401 0 0 0 0 K21163 0.0 0.0313390313390313 sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 233.0 12.0 8.0 2.0 0.75 C 0.0 15.0 2.0 0.75 COG4658 Na+-translocating_ferredoxin:NAD+_oxidoreductase__RNF,_RnfD_subunit RnfD 15.0 0.0 1.0 0.0557636369339275 0.090623101746522 0.0731933693402247 0.0348594648125944 0 0 0 0 K21164 0.0 0.0085470085470085 sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 431.0 3.0 1.0 2.0 0.6 Q 0.0 5.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 5.0 0.0 1.0 0.0050296396495084 0.0138454027769361 0.0094375212132222 0.0088157631274277 0 0 0 0 K21165 0.0 0.0085470085470085 sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 176.0 0.0 3.0 1.0 1.0 2D8S2 3.0 0.0 1.0 0 0 0 0 K21166 0.0 0.0085470085470085 sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 550.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG2303 Choline_dehydrogenase_or_related_flavoprotein BetA 3.0 0.0 1.0 0 0 0 0 K21167 0.0 0.0085470085470085 sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 267.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 28HG7 3.0 0.0 1.0 0 0 0 0 K21169 0.0028571428571428 0.0313390313390313 calE2; enediyne biosynthesis protein CalE2 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 276.0 11.0 10.0 2.0 0.916666666666667 E 1.0 11.0 1.0 1.0 COG2040 Homocysteine/selenocysteine_methylase_(S-methylmethionine-dependent) MHT1 12.0 0.0833333333333333 0.9166666666666666 0.0177144348937934 0.0617793178845788 0.0397468763891861 0.0440648829907854 0 0 0 0 K21172 0.0 0.0056980056980056 calE5; enediyne biosynthesis protein CalE5 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 258.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 2.0 0.0 1.0 0 0 0 0 K21173 0.0 0.0085470085470085 calE6; methionine gamma-lyase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 375.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0626 Cystathionine_beta-lyase/cystathionine_gamma-synthase MetC 3.0 0.0 1.0 0 0 0 0 K21174 0.0028571428571428 0.0056980056980056 calE9; enediyne biosynthesis protein CalE9 path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 89.0 3.0 0.0 1.0 1.0 E 1.0 2.0 1.0 1.0 COG0520 Selenocysteine_lyase/Cysteine_desulfurase CsdA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K21178 0.0 0.0028490028490028 sgcD4; O-methyltransferase [EC:2.1.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 371.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 1.0 0.0 1.0 0 0 0 0 K21181 0.0 0.0113960113960113 sgcC4, mdpC4; MIO-dependent L-tyrosine 2,3-aminomutase [EC:5.4.3.6] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 515.0 5.0 0.0 1.0 1.0 E 0.0 5.0 1.0 1.0 COG2986 Histidine_ammonia-lyase HutH 5.0 0.0 1.0 0.0665111732767103 0.166578197474773 0.1165446853757416 0.1000670241980627 0 0 0 0 K21182 0.0 0.0085470085470085 sgcC1, mdpC1; (S)-beta-tyrosine adenylation enzyme [EC:6.2.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 386.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 3.0 0.0 1.0 0 0 0 0 K21183 0.0 0.0113960113960113 sgcC2, mdpC2, kedY2; peptidyl carrier protein 44.0 3.0 2.0 2.0 0.75 Q 0.0 4.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 4.0 0.0 1.0 0.0145381469385714 0.0474165141230587 0.030977330530815 0.0328783671844873 0 0 0 0 K21184 0.0 0.0056980056980056 sgcC, mdpC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 526.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2368 Aromatic_ring_hydroxylase YoaI 2.0 0.0 1.0 0 0 0 0 K21185 0.0 0.0284900284900284 sgcE6, mdpE6, kedE6; flavin reductase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 145.0 9.0 5.0 3.0 0.642857142857143 S 0.0 14.0 2.0 0.785714285714286 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 14.0 0.0 1.0 0.0036380165156656 0.0181711247377257 0.0109045706266956 0.0145331082220601 0 0 0 0 K21186 0.0 0.0056980056980056 sgcC5, mdpC5, kedY5; condensation enzyme path:map01059 Biosynthesis of enediyne antibiotics 449.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG1020 EntF,_seryl-AMP_synthase_component__of_non-ribosomal_peptide_synthetase EntF 2.0 0.0 1.0 0 0 0 0 K21188 0.0028571428571428 0.0028490028490028 mdpC7; PLP-dependent transaminase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 283.0 2.0 0.0 1.0 1.0 H 1.0 1.0 1.0 1.0 COG0161 Adenosylmethionine-8-amino-7-oxononanoate_aminotransferase BioA 2.0 0.5 0.5 0 0 0 0 K21189 0.0 0.0056980056980056 mdpC6; O-methyltransferase [EC:2.1.1.-] path:map01059 Biosynthesis of enediyne antibiotics 210.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 2.0 0.0 1.0 0 0 0 0 K21190 0.0 0.0028490028490028 mdpC8; dehydrogenase path:map01059 Biosynthesis of enediyne antibiotics 114.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG1064 D-arabinose_1-dehydrogenase,_Zn-dependent_alcohol_dehydrogenase_family AdhP 1.0 0.0 1.0 0 0 0 0 K21191 0.0 0.0113960113960113 mdpB2; CoA ligase [EC:6.2.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 540.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG1021 EntE,_2,3-dihydroxybenzoate-AMP_synthase_component_of_non-ribosomal_peptide_synthetase EntE 4.0 0.0 1.0 2.80957503714035e-05 0.0003074498135449 0.0001677727819581 0.0002793540631734 0 0 0 0 K21192 0.0 0.0085470085470085 mdpB1; methyltransferase [EC:2.1.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 206.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 3.0 0.0 1.0 0 0 0 0 K21193 0.0 0.0113960113960113 mdpB3; acetyltransferase/esterase path:map01059 Biosynthesis of enediyne antibiotics 172.0 2.0 0.0 2.0 0.5 S 0.0 4.0 1.0 1.0 COG1073 Fermentation-respiration_switch_esterase_FrsA,_DUF1100_family FrsA 4.0 0.0 1.0 0.0376208949125847 0.0887486725550515 0.0631847837338181 0.0511277776424668 0 0 0 0 K21195 0.0 0.017094017094017 phnY; 2-aminoethylphosphonate dioxygenase [EC:1.14.11.46] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 237.0 7.0 0.0 1.0 1.0 Q 0.0 7.0 1.0 1.0 COG5285 Ectoine_hydroxylase-related_dioxygenase,_phytanoyl-CoA_dioxygenase_(PhyH)_family PhyH 7.0 0.0 1.0 0.0032479302127103 0.0021598601712949 0.0027038951920026 0.0010880700414153 0 0 0 0 K21196 0.0 0.0142450142450142 phnZ; 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) [EC:1.13.11.78] path:map00440,path:map01100 Phosphonate and phosphinate metabolism,Metabolic pathways 184.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG4341 Predicted_HD_phosphohydrolase 5.0 0.0 1.0 0.0095466506609575 0.0229321537780469 0.0162394022195022 0.0133855031170894 0 0 0 0 K21200 0.0 0.0028490028490028 CYP144; cytochrome P450 family 144 397.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 1.0 0.0 1.0 0 0 0 0 K21201 0.0057142857142857 0.0 CYP119; cytochrome P450 family 119 [EC:1.11.1.7] 359.0 2.0 0.0 1.0 1.0 C 2.0 0.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 1.0 0.0 0 0 0 0 K21209 0.0 0.0113960113960113 ncsB4; acyltransferase path:map01059 Biosynthesis of enediyne antibiotics 256.0 6.0 0.0 1.0 1.0 I 0.0 6.0 1.0 1.0 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 6.0 0.0 1.0 4.56869054112835e-05 0.0044347077678574 0.0022401973366343 0.0043890208624461 0 0 0 0 K21210 0.0028571428571428 0.0056980056980056 ncsC; NDP-mannose synthase path:map01059,path:map01110 Biosynthesis of enediyne antibiotics,Biosynthesis of secondary metabolites 226.0 3.0 0.0 1.0 1.0 JM 1.0 2.0 1.0 1.0 COG1208 NDP-sugar_pyrophosphorylase,_includes_eIF-2Bgamma,_eIF-2Bepsilon,_and_LPS_biosynthesis_protein_s GCD1 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K21211 0.0 0.0085470085470085 ncsC1; NDP-hexose 4,6-dehydratase path:map01059,path:map01110 Biosynthesis of enediyne antibiotics,Biosynthesis of secondary metabolites 321.0 2.0 1.0 2.0 0.666666666666667 GM 0.0 3.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 3.0 0.0 1.0 0 0 0 0 K21214 0.0 0.0056980056980056 ncsC4; NDP-hexose 4-ketoreductase path:map01059,path:map01110 Biosynthesis of enediyne antibiotics,Biosynthesis of secondary metabolites 279.0 2.0 0.0 1.0 1.0 GM 0.0 2.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 2.0 0.0 1.0 0 0 0 0 K21217 0.0 0.0113960113960113 motX; sodium-type polar flagellar protein MotX path:map02040 Flagellar assembly 197.0 4.0 0.0 1.0 1.0 N 0.0 4.0 1.0 1.0 COG0790 TPR_repeat TPR 4.0 0.0 1.0 5.30548186202239e-12 3.38093467628781e-08 1.690732612237006e-08 3.3804041281016084e-08 0 0 0 0 K21218 0.0 0.0341880341880341 motY; sodium-type flagellar protein MotY path:map02040 Flagellar assembly 257.0 10.0 8.0 2.0 0.833333333333333 M 0.0 12.0 2.0 0.916666666666667 COG2885 Outer_membrane_protein_OmpA_and_related_peptidoglycan-associated_(lipo)proteins OmpA 12.0 0.0 1.0 0.0125947997215418 0.0181981918994688 0.0153964958105053 0.005603392177927 0 0 0 0 K21219 0.5314285714285715 0.0712250712250712 thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 161.0 219.0 212.0 2.0 0.969026548672566 H 198.0 26.0 3.0 0.969026548672566 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine_kinase ThiD 224.0 0.8839285714285714 0.1160714285714285 0.570404426393939 0.526108533226844 0.5482564798103915 0.0442958931670949 0 1 0 1 K21220 0.2228571428571428 0.0028490028490028 thiN; thiamine-phosphate diphosphorylase [EC:2.5.1.3] path:map00730,path:map01100,path:map01240 Thiamine metabolism,Metabolic pathways,Biosynthesis of cofactors 98.0 67.0 53.0 4.0 0.67 H 93.0 1.0 4.0 0.5 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine_kinase ThiD 94.0 0.9893617021276596 0.0106382978723404 0.184689515314653 0.168480439546886 0.1765849774307695 0.016209075767767 0 0 0 0 K21224 0.0028571428571428 0.0028490028490028 kedN5; radical SAM C-methyltransferase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 389.0 2.0 0.0 1.0 1.0 C 1.0 1.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 2.0 0.5 0.5 0 0 0 0 K21231 0.0028571428571428 0.0512820512820512 bciB; 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) [EC:1.3.7.13] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 379.0 24.0 0.0 1.0 1.0 C 1.0 23.0 1.0 1.0 COG1035 Coenzyme_F420-reducing_hydrogenase,_beta_subunit FrhB 24.0 0.0416666666666666 0.9583333333333334 0.0081414388005452 0.0144966826516628 0.011319060726104 0.0063552438511176 0 0 0 0 K21232 0.0 0.0028490028490028 MOCS2A, CNXG; molybdopterin synthase sulfur carrier subunit path:map04122 Sulfur relay system 102.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 KOG3474 1.0 0.0 1.0 0 0 0 0 K21252 0.0 0.0313390313390313 fosX; fosfomycin resistance protein FosX 127.0 11.0 0.0 1.0 1.0 E 0.0 11.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 11.0 0.0 1.0 0.0236434208010345 0.0677503678204896 0.045696894310762 0.0441069470194551 0 0 0 0 K21253 0.0 0.0085470085470085 fosA; glutathione S-transferase fosA [EC:2.5.1.18] 99.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 3.0 0.0 1.0 0 0 0 0 K21255 0.0 0.0028490028490028 calO6; orsellinic acid C2-O-methyltransferase [EC:2.1.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 322.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 1.0 0.0 1.0 0 0 0 0 K21256 0.0 0.0113960113960113 calO3; flavin-dependent halogenase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 507.0 12.0 0.0 1.0 1.0 C 0.0 12.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 12.0 0.0 1.0 0.0049273321877349 0.0069997475294977 0.0059635398586163 0.0020724153417627 0 0 0 0 K21257 0.0 0.0056980056980056 calO2; orsellenic acid P450 oxidase [EC:1.14.-.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 393.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K21258 0.0 0.0028490028490028 calO1; orsellinic acid C3-O-methyltransferase [EC:2.1.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 340.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 1.0 0.0 1.0 0 0 0 0 K21260 0.0 0.0028490028490028 calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 393.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K21261 0.0 0.0028490028490028 calO4; acyltransferase path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 347.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 1.0 0.0 1.0 0 0 0 0 K21262 0.0 0.0028490028490028 calG4; calicheamicin aminopentosyltransferase [EC:2.4.2.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 393.0 1.0 0.0 1.0 1.0 CG 0.0 1.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 1.0 0.0 1.0 0 0 0 0 K21263 0.0 0.0056980056980056 calG1; calicheamicin 3'-O-methyl-rhamnosyltransferase [EC:2.4.1.-] path:map01059,path:map01100,path:map01110 Biosynthesis of enediyne antibiotics,Metabolic pathways,Biosynthesis of secondary metabolites 299.0 2.0 0.0 1.0 1.0 CG 0.0 2.0 1.0 1.0 COG1819 UDP:flavonoid_glycosyltransferase_YjiC,_YdhE_family YjiC 2.0 0.0 1.0 0 0 0 0 K21264 0.0 0.0085470085470085 fosA2; glutathione S-transferase fosA2 [EC:2.5.1.18] 99.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 3.0 0.0 1.0 0 0 0 0 K21265 0.0 0.0085470085470085 fosA5; glutathione S-transferase fosA5 [EC:2.5.1.18] 99.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0346 Catechol_2,3-dioxygenase_or_related_enzyme,_vicinal_oxygen_chelate_(VOC)_family GloA 3.0 0.0 1.0 0 0 0 0 K21267 0.0 0.0028490028490028 iri, rox; rifampicin monooxygenase [EC:1.14.13.211] 475.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K21268 0.0885714285714285 0.0 gdS-2; hexaprenyl diphosphate synthase [EC:2.5.1.82] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 192.0 31.0 0.0 1.0 1.0 H 31.0 0.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 31.0 1.0 0.0 0.238940189672472 0.724118017856269 0.4815291037643704 0.4851778281837969 0 0 0 0 K21271 0.0 0.0313390313390313 auaH; aurachin B dehydrogenase [EC:1.1.1.394] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 312.0 11.0 0.0 1.0 1.0 M 0.0 11.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 11.0 0.0 1.0 0.0084055166491509 0.0090783538112123 0.0087419352301815 0.0006728371620613 0 0 0 0 K21272 0.0 0.0028490028490028 auaG; aurachin C monooxygenase/isomerase [EC:1.14.13.222] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 345.0 1.0 0.0 1.0 1.0 CH 0.0 1.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 1.0 0.0 1.0 0 0 0 0 K21273 0.0 0.0968660968660968 E2.5.1.88; trans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.88] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 248.0 28.0 22.0 2.0 0.823529411764706 I 0.0 34.0 1.0 1.0 COG0020 Undecaprenyl_pyrophosphate_synthase UppS 34.0 0.0 1.0 0.0012273887422518 0.0040854480908827 0.0026564184165672 0.0028580593486309 0 0 0 0 K21275 0.0028571428571428 0.0484330484330484 hexs-b; hexaprenyl-diphosphate synthase large subunit [EC:2.5.1.83] path:map00900,path:map01110 Terpenoid backbone biosynthesis,Biosynthesis of secondary metabolites 283.0 18.0 0.0 1.0 1.0 H 1.0 17.0 1.0 1.0 COG0142 Geranylgeranyl_pyrophosphate_synthase IspA 18.0 0.0555555555555555 0.9444444444444444 0.0039564614149683 0.0094726591131187 0.0067145602640435 0.0055161976981504 0 0 0 0 K21276 0.0 0.0028490028490028 blaOXA-22; beta-lactamase class D OXA-22 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 69.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K21277 0.0 0.0028490028490028 blaOXA-60; beta-lactamase class D OXA-60 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 266.0 1.0 0.0 1.0 1.0 V 0.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 1.0 0.0 1.0 0 0 0 0 K21279 0.0028571428571428 0.0142450142450142 E2.5.1.132; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase [EC:2.5.1.132] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 281.0 6.0 0.0 1.0 1.0 M 1.0 5.0 1.0 1.0 COG2089 Sialic_acid_synthase_SpsE,_contains_C-terminal_SAF_domain SpsE 6.0 0.1666666666666666 0.8333333333333334 0.016012738665146 0.0336933719794374 0.0248530553222917 0.0176806333142914 0 0 0 0 K21281 0.0 0.0056980056980056 vlmH; isobutylamine N-monooxygenase [EC:1.14.14.30] 373.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 4.0 0.0 1.0 4.74603281507941e-13 2.0186235977543397e-12 1.2466134396311406e-12 1.544020316246399e-12 0 0 0 0 K21284 0.0 0.0056980056980056 acmA, sibE; 3-hydroxy-4-methylanthranilate adenylyltransferase [EC:2.7.7.97] 433.0 4.0 0.0 1.0 1.0 IQ 0.0 4.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 4.0 0.0 1.0 0.002737790998939 0.0094655915688811 0.00610169128391 0.0067278005699421 0 0 0 0 K21285 0.0 0.0085470085470085 tagB, tarB; teichoic acid glycerol-phosphate primase [EC:2.7.8.44] path:map00552 Teichoic acid biosynthesis 269.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG1887 CDP-glycerol_glycerophosphotransferase,_TagB/SpsB_family TagB 3.0 0.0 1.0 0 0 0 0 K21288 0.0 0.0028490028490028 arr2; rifampin ADP-ribosylating transferase 115.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DK0G 1.0 0.0 1.0 0 0 0 0 K21297 0.0 0.0028490028490028 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] path:map00253,path:map01057,path:map01100,path:map01110 Tetracycline biosynthesis,Biosynthesis of type II polyketide products,Metabolic pathways,Biosynthesis of secondary metabolites 168.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 2.0 0.0 1.0 0 0 0 0 K21298 0.0 0.0256410256410256 E2.4.1.333; 1,2-beta-oligoglucan phosphorylase [EC:2.4.1.333] 362.0 9.0 0.0 1.0 1.0 G 0.0 9.0 1.0 1.0 COG3459 Cellobiose_phosphorylase 9.0 0.0 1.0 0.0556588579927452 0.133866448159439 0.0947626530760921 0.0782075901666937 0 0 0 0 K21302 0.0057142857142857 0.0113960113960113 sapM; phosphatidylinositol-3-phosphatase [EC:3.1.3.64] path:map00562,path:map01100,path:map05152 Inositol phosphate metabolism,Metabolic pathways,Tuberculosis 273.0 11.0 0.0 1.0 1.0 M 5.0 6.0 1.0 1.0 COG3511 Phospholipase_C PlcC 11.0 0.4545454545454545 0.5454545454545454 0.0149561138376 0.112405992772183 0.0636810533048915 0.097449878934583 0 0 0 0 K21303 0.0 0.0569800569800569 wecP; UDP-GalNAc:undecaprenyl-phosphate GalNAc-1-phosphate transferase [EC:2.7.8.40] 257.0 20.0 0.0 1.0 1.0 M 0.0 20.0 4.0 0.4 COG2148 Sugar_transferase_involved_in_LPS_biosynthesis_(colanic,_teichoic_acid) WcaJ 20.0 0.0 1.0 0.178379490642743 0.104143079105194 0.1412612848739685 0.074236411537549 0 0 0 0 K21304 0.06 0.0085470085470085 aglK; UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminyltransferase [EC:2.4.1.153] 207.0 24.0 0.0 1.0 1.0 M 21.0 3.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 24.0 0.875 0.125 0.004868596307639 0.0580699554192079 0.0314692758634234 0.0532013591115689 0 0 0 0 K21305 0.02 0.0 aglC; dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase [EC:2.4.1.335] 124.0 8.0 0.0 1.0 1.0 M 8.0 0.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 8.0 1.0 0.0 0.0277089365050204 0.101398104033729 0.0645535202693746 0.0736891675287085 0 0 0 0 K21306 0.1371428571428571 0.0056980056980056 aglB; dolichyl-phosphooligosaccharide-protein glycotransferase [EC:2.4.99.21] 337.0 47.0 37.0 2.0 0.824561403508772 M 55.0 2.0 1.0 1.0 COG1287 Asparagine_N-glycosylation_enzyme,_membrane_subunit_Stt3 Stt3 57.0 0.9649122807017544 0.0350877192982456 0.971521479302857 0.986927804807749 0.979224642055303 0.0154063255048919 0 0 1 1 K21307 0.0285714285714285 0.0569800569800569 soeA; sulfite dehydrogenase (quinone) subunit SoeA [EC:1.8.5.6] path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 625.0 38.0 0.0 1.0 1.0 C 10.0 28.0 1.0 1.0 COG0243 Anaerobic_selenocysteine-containing_dehydrogenase BisC 38.0 0.2631578947368421 0.7368421052631579 0.0046113211756976 0.140929147447669 0.0727702343116833 0.1363178262719714 0 0 0 0 K21308 0.0571428571428571 0.0455840455840455 soeB; sulfite dehydrogenase (quinone) subunit SoeB path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 143.0 36.0 0.0 1.0 1.0 C 20.0 16.0 2.0 0.972222222222222 COG0437 Fe-S-cluster-containing_dehydrogenase_component_(DMSO_reductase) HybA 36.0 0.5555555555555556 0.4444444444444444 0.0911227794166004 0.299705485840029 0.1954141326283147 0.2085827064234285 0 0 0 0 K21309 0.0 0.0427350427350427 soeC; sulfite dehydrogenase (quinone) subunit SoeC path:map00920,path:map01100,path:map01120 Sulfur metabolism,Metabolic pathways,Microbial metabolism in diverse environments 277.0 15.0 0.0 1.0 1.0 S 0.0 15.0 1.0 1.0 COG3302 DMSO_reductase_anchor_subunit_DmsC DmsC 15.0 0.0 1.0 0.0104994394907787 0.0231471584403252 0.0168232989655519 0.0126477189495465 0 0 0 0 K21310 0.0428571428571428 0.0512820512820512 mddA; methanethiol S-methyltransferase [EC:2.1.1.334] path:map00920,path:map01100 Sulfur metabolism,Metabolic pathways 136.0 37.0 0.0 1.0 1.0 O 18.0 19.0 1.0 1.0 COG2020 Protein-S-isoprenylcysteine_O-methyltransferase_Ste14 STE14 37.0 0.4864864864864865 0.5135135135135135 0.20200720091212 0.507570481333996 0.354788841123058 0.3055632804218759 0 0 0 0 K21312 0.0114285714285714 0.0056980056980056 bciD; bacteriochlorophyllide c C-7(1)-hydroxylase [EC:1.17.98.2] path:map00860,path:map01110 Porphyrin metabolism,Biosynthesis of secondary metabolites 340.0 6.0 0.0 1.0 1.0 K 4.0 2.0 1.0 1.0 COG2516 Biotin_synthase-related_protein,_radical_SAM_superfamily 6.0 0.6666666666666666 0.3333333333333333 0.04043734927862 0.0778563365224093 0.0591468429005146 0.0374189872437892 0 0 0 0 K21313 0.0 0.0028490028490028 1; Escherichia phage RNA polymerase [EC:2.7.7.6] path:map03240 Viral replication 625.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG5108 Mitochondrial_DNA-directed_RNA_polymerase RPO41 1.0 0.0 1.0 0 0 0 0 K21323 0.0 0.0142450142450142 mdpJ; tert-butyl alcohol monooxygenase / tert-amyl alcohol desaturase [EC:1.14.13.229 1.14.19.48] 360.0 6.0 0.0 1.0 1.0 P 0.0 6.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 6.0 0.0 1.0 0.0833686869354561 0.187989396855532 0.135679041895494 0.1046207099200759 0 0 0 0 K21324 0.0 0.0085470085470085 mdpK; tert-butyl alcohol monooxygenase/tert-amyl alcohol desaturase reductase 317.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 3.0 0.0 1.0 0 0 0 0 K21325 0.0 0.0085470085470085 calS11; dTDP-rhamnose C3-O-methyltransferase [EC:2.1.1.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 124.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 2.0 0.666666666666667 COG4122 tRNA_5-hydroxyU34_O-methylase_TrmR/YrrM TrmR 3.0 0.0 1.0 0 0 0 0 K21328 0.0 0.0085470085470085 calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-] path:map00523,path:map01100,path:map01110 Polyketide sugar unit biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 16.0 4.0 0.0 1.0 1.0 E 0.0 4.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 4.0 0.0 1.0 5.37602975740203e-12 0.110834642660823 0.0554173213330995 0.1108346426554469 0 0 0 0 K21329 0.0 0.0085470085470085 calE10; aminosugar N-oxygenase [EC:1.14.15.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 387.0 3.0 0.0 1.0 1.0 Q 0.0 3.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 3.0 0.0 1.0 0 0 0 0 K21331 0.0 0.0113960113960113 calS8, atmS8; dTDP-alpha-D-glucose dehydrogenase [EC:1.1.1.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 421.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG0677 UDP-N-acetyl-D-mannosaminuronate_dehydrogenase WecC 4.0 0.0 1.0 0.379278869013975 0.0926729325805682 0.2359759007972716 0.2866059364334068 0 0 0 0 K21332 0.0 0.0085470085470085 calS9, atmS9; dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 322.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 3.0 0.0 1.0 0 0 0 0 K21335 0.0114285714285714 0.0113960113960113 calS10, atmS10; dTDP-4-amino-2,4-dideoxy-beta-L-xylose N-methyltransferase [EC:2.1.1.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 224.0 8.0 0.0 1.0 1.0 Q 4.0 4.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 8.0 0.5 0.5 0.0143934223307407 0.280893220478632 0.1476433214046863 0.2664997981478913 0 0 0 0 K21336 0.0 0.0284900284900284 mdpA4; C-methyltransferase [EC:2.1.1.-] path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 228.0 7.0 5.0 3.0 0.7 Q 0.0 10.0 2.0 0.7 COG0500 SAM-dependent_methyltransferase SmtA 10.0 0.0 1.0 0.0085369934087639 0.0497171842310304 0.0291270888198971 0.0411801908222664 0 0 0 0 K21337 0.0 0.017094017094017 mdpA5; aminotransferase path:map00523,path:map01110 Polyketide sugar unit biosynthesis,Biosynthesis of secondary metabolites 371.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG0399 dTDP-4-amino-4,6-dideoxygalactose_transaminase WecE 6.0 0.0 1.0 0.103702790859556 0.252742847162093 0.1782228190108244 0.149040056302537 0 0 0 0 K21342 0.0 0.0284900284900284 nos2, anb2; demethyl-4-deoxygadusol synthase [EC:4.2.3.154] 350.0 9.0 8.0 2.0 0.9 E 0.0 11.0 1.0 1.0 COG0337 3-dehydroquinate_synthetase AroB 11.0 0.0 1.0 0.0150310821896855 0.0484097084952702 0.0317203953424778 0.0333786263055847 0 0 0 0 K21344 0.0057142857142857 0.0484330484330484 rfaE1; D-glycero-beta-D-manno-heptose-7-phosphate kinase [EC:2.7.1.167] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 266.0 10.0 1.0 3.0 0.5 M 2.0 17.0 2.0 0.6 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 19.0 0.1052631578947368 0.8947368421052632 0.0054918923384695 0.0050032052558431 0.0052475487971563 0.0004886870826263 0 0 0 0 K21345 0.0 0.0256410256410256 rfaE2; D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase [EC:2.7.7.70] path:map00540,path:map01100,path:map01250 Lipopolysaccharide biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 154.0 9.0 0.0 1.0 1.0 H 0.0 9.0 1.0 1.0 COG0615 Glycerol-3-phosphate_cytidylyltransferase,_cytidylyltransferase_family TagD 9.0 0.0 1.0 0.0035420487234553 0.0077175308559469 0.0056297897897011 0.0041754821324916 0 0 0 0 K21349 0.0542857142857142 0.1082621082621082 ggs; glucosylglycerate synthase [EC:2.4.1.268] 134.0 55.0 49.0 4.0 0.873015873015873 M 19.0 44.0 5.0 0.53968253968254 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 63.0 0.3015873015873015 0.6984126984126984 0.126249773546762 0.624360606080098 0.37530518981343 0.498110832533336 0 0 0 0 K21350 0.0028571428571428 0.0028490028490028 E2.4.1.329; sucrose 6(F)-phosphate phosphorylase [EC:2.4.1.329] 499.0 2.0 0.0 1.0 1.0 G 1.0 1.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 2.0 0.5 0.5 0 0 0 0 K21355 0.0 0.0028490028490028 ggp; 1,2-alpha-glucosylglycerol phosphorylase [EC:2.4.1.332] 786.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1554 Kojibiose_phosphorylase_YcjT ATH1 1.0 0.0 1.0 0 0 0 0 K21356 0.0 0.0028490028490028 MFN1; mitofusin 1 [EC:3.6.5.-] path:map04137,path:map04621,path:map05012,path:map05022 Mitophagy - animal,NOD-like receptor signaling pathway,Parkinson disease,Pathways of neurodegeneration - multiple diseases 169.0 1.0 0.0 1.0 1.0 O 0.0 1.0 1.0 1.0 COG0699 Replication_fork_clamp-binding_protein_CrfC_(dynamin-like_GTPase_family) CrfC 1.0 0.0 1.0 0 0 0 0 K21363 0.0 0.0056980056980056 wfaP, wfgD; UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase [EC:2.4.1.305] 241.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG0463 Glycosyltransferase_involved_in_cell_wall_bisynthesis WcaA 2.0 0.0 1.0 0 0 0 0 K21364 0.0 0.0142450142450142 wfeD; UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase [EC:2.4.1.304] 221.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG1922 UDP-N-acetyl-D-mannosaminuronic_acid_transferase,_WecB/TagA/CpsF_family WecG 5.0 0.0 1.0 0.10340204543247 0.198320849306882 0.150861447369676 0.094918803874412 0 0 0 0 K21366 0.0 0.0142450142450142 wbnJ, wbiP; O86/O127-antigen biosynthesis beta-1,3-galactosyltransferase [EC:2.4.1.122 2.4.1.-] path:map00542 O-Antigen repeat unit biosynthesis 254.0 5.0 0.0 1.0 1.0 M 0.0 5.0 1.0 1.0 COG1215 Glycosyltransferase,_catalytic_subunit_of_cellulose_synthase_and_poly-beta-1,6-N-acetylglucosamine_synthase BcsA 5.0 0.0 1.0 0.108231769329437 0.194379987453642 0.1513058783915395 0.0861482181242049 0 0 0 0 K21367 0.0 0.0056980056980056 wbnK, wbiQ; O86/O127-antigen biosynthesis alpha-1,2-fucosyltransferase [EC:2.4.1.308 2.4.1.-] path:map00542 O-Antigen repeat unit biosynthesis 258.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 arCOG09486 3.0 0.0 1.0 0 0 0 0 K21369 0.0 0.0284900284900284 mggA; mannosylglucosyl-3-phosphoglycerate synthase [EC:2.4.1.270] 291.0 8.0 5.0 2.0 0.727272727272727 M 0.0 11.0 1.0 1.0 COG0438 Glycosyltransferase_involved_in_cell_wall_bisynthesis RfaB 11.0 0.0 1.0 0.0498958990776928 0.0998587425660139 0.0748773208218533 0.0499628434883211 0 0 0 0 K21377 0.0142857142857142 0.0284900284900284 aziB2; 3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase [EC:2.1.1.302] 269.0 14.0 13.0 2.0 0.933333333333333 Q 5.0 10.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 15.0 0.3333333333333333 0.6666666666666666 0.0047532254578425 0.0103347809861201 0.0075440032219813 0.0055815555282776 0 0 0 0 K21378 0.0 0.0085470085470085 nphT7; acetoacetyl-CoA synthase [EC:2.3.1.194] 323.0 3.0 0.0 1.0 1.0 I 0.0 3.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 3.0 0.0 1.0 0 0 0 0 K21379 0.0114285714285714 0.037037037037037 vioB; dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase [EC:2.3.1.209] path:map00541,path:map01100,path:map01250 O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 125.0 11.0 6.0 3.0 0.578947368421053 S 5.0 14.0 3.0 0.631578947368421 COG0110 Acetyltransferase,_isoleucine_patch_superfamily WbbJ 19.0 0.2631578947368421 0.7368421052631579 0.0597983498151666 0.126907527644088 0.0933529387296273 0.0671091778289214 0 0 0 0 K21382 0.0028571428571428 0.0 albC; cyclo(L-leucyl-L-phenylalanyl) synthase [EC:2.3.2.20] 221.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 2EW5R 1.0 1.0 0.0 0 0 0 0 K21392 0.0 0.0028490028490028 AEBP1; adipocyte enhancer-binding protein 1 322.0 1.0 0.0 1.0 1.0 J 0.0 1.0 1.0 1.0 KOG1934 1.0 0.0 1.0 0 0 0 0 K21393 0.0 0.0455840455840455 yiaN; TRAP-type transport system large permease protein 416.0 19.0 18.0 2.0 0.95 G 0.0 20.0 1.0 1.0 COG1593 TRAP-type_C4-dicarboxylate_transport_system,_large_permease_component DctQ 20.0 0.0 1.0 0.0430344373751502 0.123146029553822 0.0830902334644861 0.0801115921786718 0 0 0 0 K21394 0.0028571428571428 0.0484330484330484 yiaM; TRAP-type transport system small permease protein 113.0 27.0 0.0 1.0 1.0 G 1.0 26.0 1.0 1.0 COG3090 TRAP-type_C4-dicarboxylate_transport_system,_small_permease_component_YiaM DctM 27.0 0.037037037037037 0.9629629629629628 0.0198545021300285 0.0397046204827192 0.0297795613063738 0.0198501183526907 0 0 0 0 K21395 0.0 0.1225071225071225 yiaO; TRAP-type transport system periplasmic protein 188.0 79.0 0.0 1.0 1.0 G 0.0 79.0 1.0 1.0 COG1638 TRAP-type_C4-dicarboxylate_transport_system,_periplasmic_component DctP 79.0 0.0 1.0 0.0104458779228674 0.0211325714002698 0.0157892246615686 0.0106866934774024 0 0 0 0 K21397 0.0 0.0512820512820512 K21397; ABC transport system ATP-binding/permease protein 124.0 14.0 3.0 4.0 0.482758620689655 V 0.0 28.0 4.0 0.448275862068966 COG0842 ABC-type_multidrug_transport_system,_permease_component YadH 28.0 0.0 1.0 0.190228684729113 0.0494867492495677 0.1198577169893403 0.1407419354795453 0 0 0 0 K21399 0.0028571428571428 0.0455840455840455 ortA; 2-amino-4-ketopentanoate thiolase alpha subunit [EC:2.3.1.263] 96.0 1.0 18.0 1.0 1.0 2E6IF 19.0 0.0526315789473684 0.9473684210526316 0 0 0 0 K21400 0.0028571428571428 0.0626780626780626 ortB; 2-amino-4-ketopentanoate thiolase beta subunit [EC:2.3.1.263] 451.0 24.0 0.0 1.0 1.0 E 1.0 23.0 2.0 0.875 COG0031 Cysteine_synthase CysK 24.0 0.0416666666666666 0.9583333333333334 0.0352322681873313 0.128160716411624 0.0816964922994776 0.0929284482242926 0 0 0 0 K21401 0.1057142857142857 0.1168091168091168 menJ; menaquinone-9 beta-reductase [EC:1.3.99.38] 186.0 105.0 0.0 1.0 1.0 C 59.0 46.0 1.0 1.0 COG0644 Dehydrogenase_(flavoprotein) FixC 105.0 0.5619047619047619 0.4380952380952381 0.0437815516622015 0.106867723167114 0.0753246374146577 0.0630861715049125 0 0 0 0 K21402 0.0028571428571428 0.0028490028490028 noeI; 2-O-methyltransferase [EC:2.1.1.-] 190.0 1.0 0.0 2.0 0.5 J 1.0 1.0 1.0 1.0 COG0275 16S_rRNA_C1402_N4-methylase_RsmH RmsH 2.0 0.5 0.5 0 0 0 0 K21405 0.0114285714285714 0.1937321937321937 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR 150.0 64.0 16.0 5.0 0.492307692307692 K 4.0 126.0 10.0 0.707692307692308 COG3284 Transcriptional_regulator_DhaR_of_acetoin/glycerol_metabolism AcoR 130.0 0.0307692307692307 0.9692307692307692 0.0110086227737977 0.206426111164255 0.1087173669690263 0.1954174883904573 0 0 0 0 K21416 0.1942857142857142 0.2136752136752136 acoA; acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha [EC:1.1.1.-] 234.0 202.0 0.0 1.0 1.0 C 84.0 118.0 2.0 0.97029702970297 COG1071 TPP-dependent_pyruvate_or_acetoin_dehydrogenase_subunit_alpha AcoA 202.0 0.4158415841584158 0.5841584158415841 0.942273762956558 0.996425016928126 0.969349389942342 0.054151253971568 1 1 1 1 K21417 0.1742857142857143 0.2336182336182336 acoB; acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta [EC:1.1.1.-] 280.0 216.0 0.0 1.0 1.0 C 76.0 140.0 1.0 1.0 COG0022 Pyruvate/2-oxoglutarate/acetoin_dehydrogenase_complex,_dehydrogenase_(E1)_component,_beta_subunit AcoB 216.0 0.3518518518518518 0.6481481481481481 0.32002867515492 0.966021044496527 0.6430248598257235 0.645992369341607 0 0 0 0 K21420 0.0 0.1851851851851851 bpt; leucyl-tRNA---protein transferase [EC:2.3.2.29] 146.0 63.0 61.0 2.0 0.969230769230769 O 0.0 65.0 2.0 0.969230769230769 COG2935 Arginyl-tRNA--protein-N-Asp/Glu_arginylyltransferase Ate1 65.0 0.0 1.0 0.0085576169590651 0.0179549435166878 0.0132562802378764 0.0093973265576227 0 0 0 0 K21429 0.0028571428571428 0.0199430199430199 impA; immunomodulating metalloprotease 119.0 3.0 0.0 1.0 1.0 G 1.0 7.0 2.0 0.625 COG4894 Putative_phospholipid_scramblase_YxjI,_Tubby2_superfamily YxjI 8.0 0.125 0.875 0.0593342670963249 0.123117093205159 0.0912256801507419 0.0637828261088341 0 0 0 0 K21430 0.0628571428571428 0.2165242165242165 yliI; aldose sugar dehydrogenase [EC:1.1.5.-] 131.0 130.0 128.0 4.0 0.970149253731343 G 40.0 94.0 3.0 0.947761194029851 COG2133 Glucose/arabinose_dehydrogenase,_beta-propeller_fold YliI 134.0 0.2985074626865671 0.7014925373134329 0.0055261666556713 0.0336374938130473 0.0195818302343593 0.028111327157376 0 0 0 0 K21431 0.0 0.0085470085470085 kdc; alpha-keto-acid decarboxylase [EC:4.1.1.-] 522.0 3.0 0.0 1.0 1.0 GH 0.0 3.0 1.0 1.0 COG3961 TPP-dependent_2-oxoacid_decarboxylase,_includes_indolepyruvate_decarboxylase PDC1 3.0 0.0 1.0 0 0 0 0 K21439 0.0 0.0028490028490028 ANKRD49; ankyrin repeat domain-containing protein 49 132.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG0666 Ankyrin_repeat ANKYR 1.0 0.0 1.0 0 0 0 0 K21440 0.0 0.0313390313390313 ANKRD50; ankyrin repeat domain-containing protein 50 96.0 7.0 2.0 3.0 0.538461538461538 S 0.0 13.0 3.0 0.769230769230769 COG0666 Ankyrin_repeat ANKYR 13.0 0.0 1.0 0.0340448211242599 0.152792568413257 0.0934186947687584 0.1187477472889971 0 0 0 0 K21449 0.0 0.0 ata, sadA, emaA; trimeric autotransporter adhesin 36.0 5.0 20.0 0.183673469387755 UW 0.0 0.0 49.0 0.128440366972477 COG5295 Autotransporter_adhesin Hia 0.0 0 0 0 0 K21453 0.0 0.0028490028490028 icaR; TetR/AcrR family transcriptional regulator, biofilm operon repressor 191.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 1.0 0.0 1.0 0 0 0 0 K21454 0.0 0.0085470085470085 tcaR; MarR family transcriptional regulator, teicoplanin-associated locus regulator 129.0 4.0 0.0 1.0 1.0 K 0.0 4.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 4.0 0.0 1.0 0.246973247255177 0.0295190929655632 0.1382461701103701 0.2174541542896138 0 0 0 0 K21457 0.0 0.0056980056980056 mppJ; phenylpyruvate C(3)-methyltransferase [EC:2.1.1.281] 187.0 2.0 0.0 1.0 1.0 M 0.0 2.0 1.0 1.0 COG2230 Cyclopropane_fatty-acyl-phospholipid_synthase_and_related_methyltransferases Cfa 2.0 0.0 1.0 0 0 0 0 K21459 0.0 0.0056980056980056 cypM; cypemycin N-terminal methyltransferase [EC:2.1.1.301] 202.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 2.0 0.0 1.0 0 0 0 0 K21460 0.0 0.0199430199430199 sfmM2; L-tyrosine C(3)-methyltransferase [EC:2.1.1.304] 325.0 7.0 0.0 1.0 1.0 J 0.0 7.0 2.0 0.714285714285714 COG2813 16S_rRNA_G1207_methylase_RsmC RsmC 7.0 0.0 1.0 0.378618080987073 0.570481977552607 0.47455002926984 0.191863896565534 0 0 0 0 K21461 0.0 0.0028490028490028 icaD; poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein path:map00543 Exopolysaccharide biosynthesis 102.0 0.0 1.0 1.0 1.0 29IH2 1.0 0.0 1.0 0 0 0 0 K21462 0.0 0.0085470085470085 icaC; probable poly-beta-1,6-N-acetyl-D-glucosamine export protein 306.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG3936 Membrane-bound_acyltransferase_YfiQ,_involved_in_biofilm_formation YfiQ 3.0 0.0 1.0 0 0 0 0 K21463 0.0142857142857142 0.0085470085470085 tcaA; membrane-associated protein TcaA 122.0 5.0 2.0 2.0 0.625 M 5.0 3.0 2.0 0.625 arCOG01917 8.0 0.625 0.375 0.0557494643388341 0.12384798339401 0.089798723866422 0.0680985190551759 0 0 0 0 K21464 0.0 0.0911680911680911 pbpG; penicillin-binding protein 2D [EC:2.4.1.129 3.4.16.4] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 511.0 35.0 0.0 1.0 1.0 M 0.0 35.0 1.0 1.0 COG0744 Penicillin-binding_protein_1B/1F,_peptidoglycan__transglycosylase/transpeptidase MrcB 35.0 0.0 1.0 0.577274776629386 0.604377401369488 0.590826088999437 0.027102624740102 0 0 0 1 K21465 0.0 0.0484330484330484 pbpA; penicillin-binding protein A path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 614.0 17.0 0.0 1.0 1.0 M 0.0 17.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 17.0 0.0 1.0 0.0059537727523625 0.0022864468380211 0.0041201097951918 0.0036673259143414 0 0 0 0 K21466 0.0 0.037037037037037 pbpH; penicillin-binding protein H path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 616.0 13.0 0.0 1.0 1.0 M 0.0 13.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 13.0 0.0 1.0 0.0046534068356163 0.003329741367925 0.0039915741017706 0.0013236654676912 0 0 0 0 K21467 0.0 0.0455840455840455 pbpC; penicillin-binding protein 3 600.0 16.0 0.0 1.0 1.0 M 0.0 16.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 16.0 0.0 1.0 0.0731203973815421 0.114032972637275 0.0935766850094085 0.0409125752557329 0 0 0 0 K21468 0.0 0.0085470085470085 pbpI; penicillin-binding protein 4B 579.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG0768 Cell_division_protein_FtsI,_peptidoglycan_transpeptidase_(Penicillin-binding_protein_2) FtsI 3.0 0.0 1.0 0 0 0 0 K21469 0.0 0.0284900284900284 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4] path:map00550,path:map01100 Peptidoglycan biosynthesis,Metabolic pathways 310.0 11.0 0.0 1.0 1.0 V 0.0 11.0 2.0 0.909090909090909 COG1680 CubicO_group_peptidase,_beta-lactamase_class_C_family AmpC 11.0 0.0 1.0 0.0701828449529275 0.173116310421057 0.1216495776869922 0.1029334654681295 0 0 0 0 K21470 0.0 0.1566951566951566 ycbB; L,D-transpeptidase YcbB 192.0 56.0 45.0 4.0 0.717948717948718 S 0.0 78.0 5.0 0.923076923076923 COG2989 Murein_L,D-transpeptidase_YcbB/YkuD YcbB 78.0 0.0 1.0 0.0025013631303065 0.0038910629973982 0.0031962130638523 0.0013896998670917 0 0 0 0 K21471 0.0 0.0 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 242.0 94.0 12.0 0.557603686635945 M 0.0 0.0 27.0 0.386206896551724 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 0.0 0 0 0 0 K21472 0.0114285714285714 0.131054131054131 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-] 51.0 58.0 55.0 5.0 0.90625 M 4.0 60.0 5.0 0.8125 COG0739 Murein_DD-endopeptidase_MepM_and_murein_hydrolase_activator_NlpD,_contains_LysM_domain NlpD 64.0 0.0625 0.9375 0.0360133589705827 0.0134802188133696 0.0247467888919761 0.0225331401572131 0 0 0 0 K21473 0.0028571428571428 0.0484330484330484 ripA; peptidoglycan DL-endopeptidase RipA [EC:3.4.-.-] 183.0 24.0 21.0 2.0 0.888888888888889 M 1.0 26.0 5.0 0.814814814814815 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 27.0 0.037037037037037 0.9629629629629628 0.0052000268081247 0.0284078301392623 0.0168039284736935 0.0232078033311376 0 0 0 0 K21474 0.0 0.0142450142450142 ripB; peptidoglycan DL-endopeptidase RipB [EC:3.4.-.-] 181.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG0791 Cell_wall-associated_hydrolase,_NlpC_P60_family NlpC 7.0 0.0 1.0 3.47795612182705e-08 1.66059242280933e-08 2.56927427231819e-08 1.81736369901772e-08 0 0 0 0 K21478 0.0028571428571428 0.0142450142450142 icaB; poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase [EC:3.5.1.-] 248.0 5.0 3.0 2.0 0.714285714285714 G 1.0 6.0 1.0 1.0 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 7.0 0.1428571428571428 0.8571428571428571 0.888079396818354 0.187730968961397 0.5379051828898755 0.7003484278569571 0 0 1 1 K21479 0.0142857142857142 0.0826210826210826 cbiH60; cobalt-factor III methyltransferase [EC:2.1.1.272] path:map00860,path:map01100,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors 179.0 28.0 24.0 3.0 0.777777777777778 H 5.0 31.0 3.0 0.75 COG1010 Precorrin-3B_methylase CobJ 36.0 0.1388888888888889 0.8611111111111112 0.0089109034880389 0.0303847248470932 0.019647814167566 0.0214738213590542 0 0 0 0 K21480 0.0 0.0968660968660968 HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20] path:map00860,path:map01100,path:map01110 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 188.0 26.0 7.0 2.0 0.577777777777778 P 0.0 45.0 2.0 0.888888888888889 COG5398 Heme_oxygenase 45.0 0.0 1.0 0.0090458551670558 0.0180290148926876 0.0135374350298717 0.0089831597256318 0 0 0 0 K21481 0.0371428571428571 0.0883190883190883 mhuD; heme oxygenase (mycobilin-producing) [EC:1.14.99.57] 53.0 52.0 0.0 1.0 1.0 S 14.0 38.0 3.0 0.788461538461538 COG2329 Heme-degrading_monooxygenase_HmoA_and_related_ABM_domain_proteins HmoA 52.0 0.2692307692307692 0.7307692307692307 0.0251729035774704 0.0185321906574648 0.0218525471174675 0.0066407129200056 0 0 0 0 K21487 0.0028571428571428 0.0028490028490028 yobL; toxin YobL [EC:3.1.-.-] 174.0 1.0 0.0 2.0 0.5 UW 1.0 1.0 1.0 1.0 COG3209 Uncharacterized_conserved_protein_RhaS,_contains_28_RHS_repeats RhsA 2.0 0.5 0.5 0 0 0 0 K21488 0.0028571428571428 0.0028490028490028 yobK; antitoxin YobK 141.0 3.0 0.0 1.0 1.0 S 1.0 2.0 1.0 1.0 2E17N 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K21489 0.0028571428571428 0.0 yokI; toxin YokI [EC:3.1.-.-] 216.0 1.0 0.0 1.0 1.0 UW 1.0 0.0 1.0 1.0 COG3209 Uncharacterized_conserved_protein_RhaS,_contains_28_RHS_repeats RhsA 1.0 1.0 0.0 0 0 0 0 K21490 0.0 0.0056980056980056 yokJ; antitoxin YokJ 155.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 28MM1 2.0 0.0 1.0 0 0 0 0 K21492 0.0 0.0056980056980056 yqcF; antitoxin YqcF 181.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DMGT 2.0 0.0 1.0 0 0 0 0 K21493 0.0 0.0113960113960113 yxiD; toxin YxiD [EC:3.1.-.-] 72.0 2.0 0.0 2.0 0.5 M 0.0 4.0 2.0 0.75 COG5444 Predicted_ribonuclease,_toxin_component_of_the_YeeF-YezG_toxin-antitoxin_module YeeF 4.0 0.0 1.0 0.0351362928522215 0.125212321856538 0.0801743073543797 0.0900760290043165 0 0 0 0 K21494 0.0 0.0028490028490028 yxxD; antitoxin YxxD 160.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2EDXZ 1.0 0.0 1.0 0 0 0 0 K21495 0.0 0.0997150997150997 fitA; antitoxin FitA 34.0 34.0 0.0 1.0 1.0 S 0.0 47.0 9.0 0.617021276595745 COG4691 Plasmid_stability_protein_StbC1,_contains_ribbon-helix-helix_domain StbC1 47.0 0.0 1.0 0.0237528405195249 0.032072716541373 0.0279127785304489 0.0083198760218481 0 0 0 0 K21498 0.0 0.2735042735042735 higA-1; antitoxin HigA-1 47.0 192.0 0.0 1.0 1.0 K 0.0 192.0 3.0 0.979274611398964 COG3093 Plasmid_maintenance_system_antidote_protein_VapI,_contains_XRE-type_HTH_domain VapI 192.0 0.0 1.0 0.0151612060825218 0.0580306581596526 0.0365959321210872 0.0428694520771308 0 0 0 0 K21511 0.0 0.0085470085470085 GPC; Escherichia phage capsid assembly protease [EC:3.4.21.-] 282.0 3.0 0.0 1.0 1.0 OU 0.0 3.0 1.0 1.0 COG0616 Periplasmic_serine_protease,_ClpP_class SppA 3.0 0.0 1.0 0 0 0 0 K21512 0.0 0.0028490028490028 gpA; Escherichia phage terminase, large subunit [EC:3.1.21.4] 641.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG5525 Phage_terminase,_large_subunit_GpA gpA1 1.0 0.0 1.0 0 0 0 0 K21514 0.0 0.017094017094017 aviRb; 23S rRNA (uridine2479-2'-O)-methyltransferase [EC:2.1.1.208] 262.0 6.0 0.0 1.0 1.0 J 0.0 6.0 1.0 1.0 COG0566 tRNA_G18_(ribose-2'-O)-methylase_SpoU SpoU 6.0 0.0 1.0 0.561845077954724 0.165260608170724 0.363552843062724 0.3965844697840001 0 0 0 1 K21515 0.0028571428571428 0.0256410256410256 aviRa; 23S rRNA (guanine2535-N1)-methyltransferase [EC:2.1.1.209] 107.0 8.0 6.0 2.0 0.8 J 1.0 9.0 3.0 0.7 COG2890 Methylase_of_polypeptide_chain_release_factors HemK 10.0 0.1 0.9 0.2972781227864 0.362315233323684 0.329796678055042 0.065037110537284 0 0 0 0 K21551 0.0028571428571428 0.0085470085470085 tsrM; tryptophan 2-C-methyltransferase [EC:2.1.1.106] 407.0 4.0 0.0 1.0 1.0 C 1.0 3.0 1.0 1.0 COG1032 Radical_SAM_superfamily_enzyme_YgiQ,_UPF0313_family YgiQ 4.0 0.25 0.75 0.0878141542433594 0.15697124432161 0.1223926992824847 0.0691570900782506 0 0 0 0 K21555 0.0 0.0085470085470085 cooA; CRP/FNR family transcriptional regulator, carbon monoxide oxidation system transcription regulator 204.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 3.0 0.0 1.0 0 0 0 0 K21556 0.0028571428571428 0.017094017094017 malR; CRP/FNR family transcriptional regulator, polysaccharide utilization system transcription regulator 206.0 5.0 1.0 2.0 0.555555555555556 K 1.0 8.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 9.0 0.1111111111111111 0.8888888888888888 0.0486657297804037 0.0234093229176513 0.0360375263490275 0.0252564068627524 0 0 0 0 K21558 0.0 0.0113960113960113 cprK; CRP/FNR family transcriptional regulator, reductive dehalogenation system regulator 185.0 6.0 5.0 2.0 0.857142857142857 T 0.0 7.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 7.0 0.0 1.0 0.0059840211742052 0.0147712785556789 0.010377649864942 0.0087872573814737 0 0 0 0 K21559 0.0 0.0313390313390313 cprC; NosR/NirI family transcriptional regulator, putative reductive dehalogenation system regulator 170.0 11.0 0.0 1.0 1.0 C 0.0 11.0 2.0 0.909090909090909 COG4659 Na+-translocating_ferredoxin:NAD+_oxidoreductase_RNF,_RnfG_subunit RnfG 11.0 0.0 1.0 0.959397186940634 0.552624296353768 0.7560107416472011 0.406772890586866 0 0 1 1 K21560 0.0 0.0028490028490028 prfA; CRP/FNR family transcriptional regulator, listeriolysin regulatory protein 230.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 1.0 0.0 1.0 0 0 0 0 K21561 0.0 0.0484330484330484 ntcA; CRP/FNR family transcriptional regulator, global nitrogen regulator 221.0 15.0 13.0 2.0 0.882352941176471 K 0.0 17.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 17.0 0.0 1.0 0.0004922925551604 0.0010010251264582 0.0007466588408093 0.0005087325712978 0 0 0 0 K21562 0.0028571428571428 0.0626780626780626 flp; CRP/FNR family transcriptional regulator, anaerobic regulatory protein 163.0 17.0 7.0 2.0 0.62962962962963 K 1.0 26.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 27.0 0.037037037037037 0.9629629629629628 0.263320926666591 0.238828216937904 0.2510745718022475 0.024492709728687 0 0 0 0 K21563 0.0 0.1595441595441595 dnr; CRP/FNR family transcriptional regulator, dissimilatory nitrate respiration regulator 143.0 62.0 52.0 2.0 0.861111111111111 K 0.0 72.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 72.0 0.0 1.0 0.0071925706104264 0.130189441127191 0.0686910058688087 0.1229968705167646 0 0 0 0 K21564 0.0 0.0683760683760683 nnrR; CRP/FNR family transcriptional regulator, nitrogen oxide reductase regulator 186.0 19.0 12.0 2.0 0.730769230769231 K 0.0 26.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 26.0 0.0 1.0 0.0139122304092092 0.601177174937179 0.3075447026731941 0.5872649445279698 0 0 0 0 K21566 0.0 0.0028490028490028 cprA; 3-chloro-4-hydroxyphenylacetate reductive dehalogenase [EC:3.8.1.-] 413.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1600 Epoxyqueuosine_reductase_QueG_(queuosine_biosynthesis) QueG 2.0 0.0 1.0 0 0 0 0 K21567 0.08 0.1339031339031339 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1] 196.0 46.0 5.0 2.0 0.528735632183908 C 29.0 58.0 2.0 0.977011494252874 COG0492 Thioredoxin_reductase TrxB 87.0 0.3333333333333333 0.6666666666666666 0.315415014180112 0.0602407015263671 0.1878278578532395 0.2551743126537448 0 0 0 0 K21571 0.0 0.0484330484330484 susE_F; starch-binding outer membrane protein SusE/F 135.0 21.0 18.0 5.0 0.777777777777778 S 0.0 28.0 11.0 0.285714285714286 28JY0 28.0 0.0 1.0 0.0031862538012243 0.007826047861074 0.0055061508311491 0.0046397940598496 0 0 0 0 K21572 0.0057142857142857 0.1538461538461538 susD; starch-binding outer membrane protein, SusD/RagB family 10.0 232.0 132.0 12.0 0.343703703703704 S 2.0 665.0 28.0 0.152046783625731 COG0702 Uncharacterized_conserved_protein_YbjT,_contains_NAD(P)-binding_and_DUF2867_domains YbjT 667.0 0.0029985007496251 0.9970014992503748 0.0016546565645251 0.0035062736197145 0.0025804650921198 0.0018516170551894 0 0 0 0 K21573 0.0 0.037037037037037 susC; TonB-dependent starch-binding outer membrane protein SusC 891.0 12.0 11.0 2.0 0.923076923076923 P 0.0 13.0 2.0 0.923076923076923 COG1629 Outer_membrane_receptor_protein,_Fe_transport CirA 13.0 0.0 1.0 0.0073395475279737 0.0334065911196328 0.0203730693238032 0.0260670435916591 0 0 0 0 K21574 0.0 0.0398860398860398 susB; glucan 1,4-alpha-glucosidase [EC:3.2.1.3] path:map00500,path:map01100 Starch and sucrose metabolism,Metabolic pathways 643.0 11.0 7.0 2.0 0.733333333333333 G 0.0 15.0 2.0 0.733333333333333 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 15.0 0.0 1.0 0.0263714226444426 0.0440468846775686 0.0352091536610056 0.017675462033126 0 0 0 0 K21575 0.0 0.074074074074074 susA; neopullulanase [EC:3.2.1.135] 397.0 31.0 0.0 1.0 1.0 G 0.0 31.0 2.0 0.903225806451613 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 31.0 0.0 1.0 0.0089237400461681 0.0223934526174354 0.0156585963318017 0.0134697125712672 0 0 0 0 K21576 0.0 0.0569800569800569 grdD; glycine/sarcosine/betaine reductase complex component C subunit alpha [EC:1.21.4.2 1.21.4.3 1.21.4.4] 247.0 26.0 0.0 1.0 1.0 I 0.0 24.0 1.0 1.0 COG0416 Acyl-ACP:phosphate_acyltransferase_(fatty_acid/phospholipid_biosynthesis) PlsX 24.0 0.0 1.0 0.0184963903125515 0.807566077945754 0.4130312341291527 0.7890696876332025 0 0 0 0 K21577 0.0 0.0626780626780626 grdC; glycine/sarcosine/betaine reductase complex component C subunit beta [EC:1.21.4.2 1.21.4.3 1.21.4.4] 283.0 24.0 23.0 2.0 0.96 I 0.0 25.0 2.0 0.64 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 25.0 0.0 1.0 0.0184997257724218 0.642771885117999 0.3306358054452104 0.6242721593455772 0 0 0 0 K21578 0.0 0.0227920227920227 grdI; betaine reductase complex component B subunit alpha [EC:1.21.4.4] 435.0 8.0 0.0 1.0 1.0 C 0.0 8.0 1.0 1.0 28HF7 8.0 0.0 1.0 0.0090052393427539 0.112304589476059 0.0606549144094064 0.1032993501333051 0 0 0 0 K21579 0.0 0.0284900284900284 grdH; betaine reductase complex component B subunit beta [EC:1.21.4.4] 75.0 13.0 0.0 1.0 1.0 S 0.0 13.0 1.0 1.0 COG1978 Predicted_RNase_H-related_nuclease_YkuK,_DUF458_family YkuK 13.0 0.0 1.0 0.0107353766146051 0.0468034298737776 0.0287694032441913 0.0360680532591725 0 0 0 0 K21583 0.0 0.0056980056980056 grdG; sarcosine reductase complex component B subunit alpha [EC:1.21.4.3] 427.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 28HF7 2.0 0.0 1.0 0 0 0 0 K21584 0.0 0.0056980056980056 grdF; sarcosine reductase complex component B subunit beta [EC:1.21.4.3] 349.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG1978 Predicted_RNase_H-related_nuclease_YkuK,_DUF458_family YkuK 2.0 0.0 1.0 0 0 0 0 K21585 0.0085714285714285 0.0085470085470085 kat; 3-aminobutanoyl-CoA transaminase [EC:2.6.1.111] 377.0 7.0 0.0 1.0 1.0 H 4.0 3.0 1.0 1.0 COG0001 Glutamate-1-semialdehyde_aminotransferase HemL 7.0 0.5714285714285714 0.4285714285714285 0.072985320977468 0.138376963384847 0.1056811421811575 0.065391642407379 0 0 0 0 K21591 0.0057142857142857 0.0028490028490028 tarF; teichoic acid glycerol-phosphate transferase [EC:2.7.8.45] path:map00552 Teichoic acid biosynthesis 347.0 3.0 0.0 1.0 1.0 M 2.0 1.0 1.0 1.0 COG1887 CDP-glycerol_glycerophosphotransferase,_TagB/SpsB_family TagB 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K21592 0.0 0.0028490028490028 tarK; teichoic acid ribitol-phosphate primase [EC:2.7.8.46] path:map00552 Teichoic acid biosynthesis 373.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG1887 CDP-glycerol_glycerophosphotransferase,_TagB/SpsB_family TagB 1.0 0.0 1.0 0 0 0 0 K21596 0.0171428571428571 0.0 CAMTA; calmodulin-binding transcription activator 202.0 3.0 1.0 3.0 0.5 UZ 6.0 0.0 1.0 1.0 KOG0073 6.0 1.0 0.0 0.765133002690589 0.956652674799888 0.8608928387452386 0.191519672109299 0 0 1 1 K21600 0.0142857142857142 0.4501424501424501 csoR, ricR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor 65.0 206.0 204.0 3.0 0.985645933014354 S 5.0 204.0 3.0 0.990430622009569 COG1937 DNA-binding_transcriptional_regulator,_FrmR_family FrmR 209.0 0.0239234449760765 0.9760765550239234 0.721439177417236 0.931107206660486 0.826273192038861 0.20966802924325 0 1 0 1 K21601 0.0 0.0085470085470085 ycnK; DeoR family transcriptional regulator, copper-sensing transcriptional repressor 143.0 3.0 2.0 2.0 0.75 K 0.0 4.0 2.0 0.75 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 4.0 0.0 1.0 0.0053040501248278 1.7763249645172e-09 0.0026520259505763 0.0053040483485028 0 0 0 0 K21602 0.0 0.0142450142450142 yiaJ; IclR family transcriptional regulator, carbohydrate utilization repressor 244.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 5.0 0.0 1.0 0.867442598858575 0.168441786145241 0.517942192501908 0.699000812713334 0 0 1 1 K21603 0.0 0.0113960113960113 ftcR; two-component system, OmpR family, flagellar system response regulator FtcR 185.0 2.0 0.0 2.0 0.5 K 0.0 4.0 1.0 1.0 COG0745 DNA-binding_response_regulator,_OmpR_family,_contains_REC_and_winged-helix_(wHTH)_domain OmpR 4.0 0.0 1.0 1.8067450287569296e-12 2.8006295649649e-08 1.4004051197338878e-08 2.8004488904620243e-08 0 0 0 0 K21604 0.0028571428571428 0.0 IAR3, ILL6; jasmonoyl-L-amino acid hydrolase [EC:3.5.1.127] 395.0 1.0 0.0 1.0 1.0 S 1.0 0.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 1.0 1.0 0.0 0 0 0 0 K21606 0.0171428571428571 0.017094017094017 endo_I; endo-chitodextinase [EC:3.2.1.202] 123.0 10.0 5.0 3.0 0.625 G 6.0 10.0 6.0 0.375 COG3291 Uncharacterized_conserved_protein,_PKD_repeat_domain 16.0 0.375 0.625 0.079516320226775 0.224188411681244 0.1518523659540095 0.144672091454469 0 0 0 0 K21607 0.0 0.0341880341880341 pcpD; tetrachlorobenzoquinone reductase [EC:1.1.1.404] path:map00361,path:map01100,path:map01120 Chlorocyclohexane and chlorobenzene degradation,Metabolic pathways,Microbial metabolism in diverse environments 304.0 14.0 0.0 1.0 1.0 C 0.0 14.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 14.0 0.0 1.0 0.0161020094291229 0.0261865109361401 0.0211442601826314 0.0100845015070171 0 0 0 0 K21610 0.0971428571428571 0.0 cfbC; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC [EC:6.3.3.7] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 250.0 36.0 0.0 1.0 1.0 D 36.0 0.0 1.0 1.0 COG1348 Nitrogenase_ATPase_subunit_NifH/coenzyme_F430_biosynthesis_subunit_CfbC NifH/CfbC 36.0 1.0 0.0 0.955006619168531 0.987983456961552 0.9714950380650416 0.0329768377930209 0 0 1 1 K21611 0.1628571428571428 0.0 cfbD; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD [EC:6.3.3.7] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 335.0 57.0 0.0 1.0 1.0 C 57.0 0.0 1.0 1.0 COG2710 Nitrogenase_Mo-Fe_protein_NifD/coenzyme_F430_biosynthesis_subunit_CfbD NifD/CfbD 57.0 1.0 0.0 0.0038955891788797 0.485774950047176 0.2448352696130278 0.4818793608682963 0 0 0 0 K21612 0.1657142857142857 0.0 cfbE; coenzyme F430 synthetase [EC:6.4.1.9] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 219.0 46.0 34.0 2.0 0.793103448275862 M 58.0 0.0 1.0 1.0 COG0770 UDP-N-acetylmuramyl_pentapeptide_synthase MurF 58.0 1.0 0.0 0.0047009833275184 0.0144279031626271 0.0095644432450727 0.0097269198351087 0 0 0 0 K21613 0.0057142857142857 0.0712250712250712 scmP; N-acetylcysteine deacetylase [EC:3.5.1.-] 268.0 19.0 6.0 3.0 0.527777777777778 S 2.0 34.0 1.0 1.0 COG1473 Metal-dependent_amidase/aminoacylase/carboxypeptidase AbgB 36.0 0.0555555555555555 0.9444444444444444 0.065885039902924 0.672469381337457 0.3691772106201905 0.606584341434533 0 0 0 0 K21617 0.0 0.0113960113960113 hpbD; 4-hydroxyproline betaine 2-epimerase [EC:5.1.1.22] 333.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 4.0 0.0 1.0 0.0079799952962531 0.0133322219102606 0.0106561086032568 0.0053522266140074 0 0 0 0 K21619 0.0142857142857142 0.0626780626780626 uxaE; tagaturonate epimerase [EC:5.1.2.7] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 293.0 29.0 0.0 1.0 1.0 S 5.0 24.0 2.0 0.827586206896552 2BXG3 29.0 0.1724137931034483 0.8275862068965517 0.768527065769301 0.0406682034465284 0.4045976346079147 0.7278588623227725 1 1 1 1 K21620 0.0 0.0142450142450142 sorbD; galactitol 2-dehydrogenase [EC:1.1.1.16] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 257.0 5.0 0.0 1.0 1.0 IQ 0.0 5.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 5.0 0.0 1.0 0.0022652093848603 0.0086902043662456 0.0054777068755529 0.0064249949813852 0 0 0 0 K21621 0.0 0.0085470085470085 fk; tagatose kinase [EC:2.7.1.101] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 297.0 3.0 0.0 1.0 1.0 G 0.0 3.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 3.0 0.0 1.0 0 0 0 0 K21622 0.0 0.0142450142450142 tag6PK; D-tagatose 6-phosphate 4-epimerase [EC:5.1.3.40] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 377.0 5.0 0.0 1.0 1.0 G 0.0 5.0 1.0 1.0 COG4573 Tagatose-1,6-bisphosphate_aldolase_non-catalytic_subunit_AgaZ/GatZ GatZ 5.0 0.0 1.0 0.942506786632903 0.555096992759609 0.748801889696256 0.387409793873294 0 0 1 1 K21624 0.0 0.0199430199430199 c3lhypd; cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171] path:map00330 Arginine and proline metabolism 367.0 7.0 0.0 1.0 1.0 M 0.0 7.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 7.0 0.0 1.0 5.2274676486380096e-12 8.884383879411809e-12 7.055925764024909e-12 3.6569162307738e-12 0 0 0 0 K21636 0.5 0.4245014245014245 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 140.0 376.0 352.0 9.0 0.886792452830189 F 224.0 175.0 9.0 0.792452830188679 COG1328 Anaerobic_ribonucleoside-triphosphate_reductase NrdD 399.0 0.5614035087719298 0.4385964912280701 0.934509007614452 0.918024881611848 0.92626694461315 0.0164841260026039 1 1 1 1 K21637 0.0 0.0056980056980056 iraD; anti-adapter protein IraD 114.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG3518 Predicted_component_of_the_type_VI_protein_secretion_system 2.0 0.0 1.0 0 0 0 0 K21639 0.0 0.0056980056980056 E1.4.3.25; L-arginine oxidase [EC:1.4.3.25] path:map00330,path:map01100 Arginine and proline metabolism,Metabolic pathways 397.0 2.0 0.0 1.0 1.0 E 0.0 2.0 2.0 0.5 COG1231 Monoamine_oxidase YobN 2.0 0.0 1.0 0 0 0 0 K21640 0.0742857142857142 0.0 nrpRII; global nitrogen regulator NrpRII 244.0 26.0 0.0 1.0 1.0 K 26.0 0.0 1.0 1.0 COG1693 Repressor_of_nif_and_glnA_expression 26.0 1.0 0.0 0.0005182817364835 0.000364418819446 0.0004413502779647 0.0001538629170375 0 0 0 0 K21645 0.0 0.0398860398860398 hypT, qseD; LysR family transcriptional regulator, hypochlorite-specific transcription factor HypT 230.0 22.0 0.0 1.0 1.0 K 0.0 22.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 22.0 0.0 1.0 0.0079125065598987 0.0153046477709678 0.0116085771654332 0.007392141211069 0 0 0 0 K21647 0.0 0.0085470085470085 pceA; tetrachloroethene reductive dehalogenase [EC:1.21.99.5] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 350.0 15.0 0.0 1.0 1.0 C 0.0 15.0 1.0 1.0 COG1600 Epoxyqueuosine_reductase_QueG_(queuosine_biosynthesis) QueG 15.0 0.0 1.0 4.97495438724199e-13 7.62024906462751e-13 6.29760172593475e-13 2.645294677385521e-13 0 0 0 0 K21672 0.0885714285714285 0.1082621082621082 ord; 2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26] path:map00310,path:map00330,path:map00470,path:map01100 Lysine degradation,Arginine and proline metabolism,D-Amino acid metabolism,Metabolic pathways 238.0 63.0 51.0 2.0 0.84 S 33.0 48.0 1.0 1.0 COG3804 Uncharacterized_conserved_protein 81.0 0.4074074074074074 0.5925925925925926 0.708540271023351 0.956416348758066 0.8324783098907085 0.2478760777347149 0 1 0 1 K21676 0.0 0.0028490028490028 luh; lupanine 17-hydroxylase (cytochrome c) [EC:1.17.2.2] 685.0 2.0 0.0 1.0 1.0 CG 0.0 2.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 2.0 0.0 1.0 0 0 0 0 K21677 0.0 0.0541310541310541 hpnE; hydroxysqualene dehydroxylase [EC:1.17.8.1] 331.0 12.0 9.0 4.0 0.631578947368421 H 0.0 19.0 2.0 0.736842105263158 COG1232 Protoporphyrinogen_oxidase_HemY/PPOX HemY 19.0 0.0 1.0 0.0267307049022523 0.137974824805827 0.0823527648540396 0.1112441199035747 0 0 0 0 K21678 0.0 0.0398860398860398 hpnD; presqualene diphosphate synthase [EC:2.5.1.103] 200.0 22.0 0.0 1.0 1.0 I 0.0 22.0 1.0 1.0 COG1562 Phytoene/squalene_synthetase ERG9 22.0 0.0 1.0 0.0010012623556031 0.0079436961025104 0.0044724792290567 0.0069424337469072 0 0 0 0 K21679 0.0057142857142857 0.0455840455840455 hpnC; hydroxysqualene synthase [EC:4.2.3.156] 240.0 18.0 0.0 1.0 1.0 I 2.0 16.0 1.0 1.0 COG1562 Phytoene/squalene_synthetase ERG9 18.0 0.1111111111111111 0.8888888888888888 0.0058094110364995 0.0684896955875383 0.0371495533120189 0.0626802845510388 0 0 0 0 K21680 0.0 0.0056980056980056 E1.1.1.137; ribulose-5-phosphate 2-dehydrogenase [EC:1.1.1.137] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 311.0 2.0 0.0 1.0 1.0 E 0.0 2.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 2.0 0.0 1.0 0 0 0 0 K21681 0.0228571428571428 0.0598290598290598 bcs1; ribitol-5-phosphate 2-dehydrogenase (NADP+) / D-ribitol-5-phosphate cytidylyltransferase [EC:1.1.1.405 2.7.7.40] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 143.0 26.0 19.0 2.0 0.787878787878788 I 10.0 23.0 4.0 0.606060606060606 COG1211 2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase IspD 33.0 0.303030303030303 0.696969696969697 0.0122546222142308 0.0291696180091542 0.0207121201116925 0.0169149957949234 0 0 0 0 K21684 0.0 0.0085470085470085 sdgC; salicyloyl-CoA 5-hydroxylase [EC:1.14.13.209] 511.0 3.0 0.0 1.0 1.0 CH 0.0 3.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 3.0 0.0 1.0 0 0 0 0 K21685 0.0 0.0256410256410256 ramA; LuxR family transcriptional regulator, regulator of acetate metabolism 268.0 9.0 7.0 2.0 0.818181818181818 K 0.0 11.0 3.0 0.818181818181818 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 11.0 0.0 1.0 0.0099665691637058 0.0188802761082094 0.0144234226359576 0.0089137069445036 0 0 0 0 K21686 0.0 0.0769230769230769 prpR; XRE family transcriptional regulator, fatty acid utilization regulator 171.0 38.0 37.0 2.0 0.974358974358974 K 0.0 39.0 3.0 0.58974358974359 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 39.0 0.0 1.0 0.0024303479038389 0.0135475186278506 0.0079889332658447 0.0111171707240117 0 0 0 0 K21687 0.0 0.0683760683760683 rpfA; resuscitation-promoting factor RpfA 45.0 22.0 4.0 2.0 0.55 M 0.0 38.0 9.0 0.35 COG1652 Cytoplasmic_potassium-binding_protein_Kbp/XkdP/YgaU,_contains_LysM_domain XkdP 38.0 0.0 1.0 0.00811448513431 0.0173799857304206 0.0127472354323652 0.0092655005961106 0 0 0 0 K21688 0.0 0.0655270655270655 rpfB; resuscitation-promoting factor RpfB 124.0 17.0 8.0 5.0 0.548387096774194 S 0.0 31.0 3.0 0.774193548387097 COG3583 Uncharacterized_conserved_protein_YabE,_contains_G5_and_tandem_DUF348_domains YabE 31.0 0.0 1.0 0.0774608380550543 0.0903122048141168 0.0838865214345855 0.0128513667590624 0 0 0 0 K21689 0.0 0.0028490028490028 rpfC; resuscitation-promoting factor RpfC 160.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1652 Cytoplasmic_potassium-binding_protein_Kbp/XkdP/YgaU,_contains_LysM_domain XkdP 1.0 0.0 1.0 0 0 0 0 K21691 0.0 0.0313390313390313 rpfE; resuscitation-promoting factor RpfE 91.0 8.0 4.0 2.0 0.666666666666667 M 0.0 12.0 3.0 0.583333333333333 COG1388 LysM_repeat LysM 12.0 0.0 1.0 0.0035223027928278 0.0200806992544867 0.0118015010236572 0.0165583964616588 0 0 0 0 K21694 0.0 0.0284900284900284 cowN; N(2)-fixation sustaining protein CowN 91.0 9.0 8.0 2.0 0.9 S 0.0 10.0 2.0 0.9 2E63D 10.0 0.0 1.0 0.0215000504822454 0.0279891550578159 0.0247446027700306 0.0064891045755705 0 0 0 0 K21695 0.0 0.0056980056980056 aaeX; protein AaeX 67.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 2DNQE 2.0 0.0 1.0 0 0 0 0 K21696 0.0 0.037037037037037 rcoM; LytTR family transcriptional regulator, CO-responsive transcriptional regulator RcoM 154.0 5.0 1.0 4.0 0.384615384615385 KT 0.0 13.0 4.0 0.692307692307692 COG3279 DNA-binding_response_regulator,_LytR/AlgR_family LytT 13.0 0.0 1.0 0.0250570525434234 0.0613972448611219 0.0432271487022726 0.0363401923176985 0 0 0 0 K21698 0.0 0.0056980056980056 aaeR; LysR family transcriptional regulator, transcriptional activator for aaeXAB operon 304.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K21699 0.0 0.0284900284900284 bauR; LysR family transcriptional regulator, transcriptional activator for bauABCD operon 244.0 15.0 0.0 1.0 1.0 K 0.0 15.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 15.0 0.0 1.0 0.0105298476092569 0.0225306540362151 0.016530250822736 0.0120008064269582 0 0 0 0 K21700 0.0028571428571428 0.0427350427350427 bauB; beta-alanine degradation protein BauB 66.0 15.0 12.0 3.0 0.75 S 1.0 19.0 3.0 0.85 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 20.0 0.05 0.95 0.0127523458919814 0.0322739939968419 0.0225131699444116 0.0195216481048605 0 0 0 0 K21701 0.0 0.0142450142450142 btr; AraC family transcriptional regulator, transcriptional activator for feuABC-ybbA operon 129.0 3.0 1.0 3.0 0.5 K 0.0 6.0 3.0 0.333333333333333 COG1917 Cupin_domain_protein_related_to_quercetin_dioxygenase QdoI 6.0 0.0 1.0 0.0258698665497686 0.0599886456763988 0.0429292561130837 0.0341187791266301 0 0 0 0 K21702 0.0 0.0028490028490028 gatDH; galactitol 2-dehydrogenase (L-tagatose-forming) [EC:1.1.1.406] 225.0 2.0 0.0 1.0 1.0 IQ 0.0 2.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 2.0 0.0 1.0 0 0 0 0 K21703 0.0 0.1025641025641025 cbbR, cmpR, ndhR; LysR family transcriptional regulator, low CO2-responsive transcriptional regulator 265.0 42.0 0.0 1.0 1.0 K 0.0 42.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 42.0 0.0 1.0 0.0077426502700448 0.140517209230083 0.0741299297500639 0.1327745589600382 0 0 0 0 K21711 0.0 0.0056980056980056 pycR; LysR family transcriptional regulator, putative pyruvate carboxylase regulator 287.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K21712 0.0 0.017094017094017 gbpA; N-acetylglucosamine-binding protein A path:map05110 Vibrio cholerae infection 167.0 4.0 3.0 3.0 0.666666666666667 S 0.0 6.0 2.0 0.833333333333333 COG3397 Predicted_carbohydrate-binding_protein,_contains_CBM5_and_CBM33_domains 6.0 0.0 1.0 0.0193664969953019 0.0431116748547539 0.0312390859250279 0.023745177859452 0 0 0 0 K21713 0.0 0.0085470085470085 lpmo; lytic chitin monoxygenase [EC:1.14.99.53] 170.0 2.0 1.0 2.0 0.666666666666667 S 0.0 3.0 1.0 1.0 COG3397 Predicted_carbohydrate-binding_protein,_contains_CBM5_and_CBM33_domains 3.0 0.0 1.0 0 0 0 0 K21721 0.0028571428571428 0.0284900284900284 sbnB; N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase [EC:1.5.1.51] path:map00997,path:map00998,path:map01100,path:map01110 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 306.0 13.0 0.0 1.0 1.0 E 1.0 12.0 1.0 1.0 COG2423 Ornithine_cyclodeaminase/archaeal_alanine_dehydrogenase,_mu-crystallin_family OCDMu 13.0 0.0769230769230769 0.9230769230769232 0.0543971589712787 0.110919533850598 0.0826583464109383 0.0565223748793193 0 0 0 0 K21726 0.0057142857142857 0.0028490028490028 npcA; 4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, oxygenase component [EC:1.14.13.29 1.14.13.166] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 467.0 3.0 0.0 1.0 1.0 Q 2.0 1.0 1.0 1.0 COG2368 Aromatic_ring_hydroxylase YoaI 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K21727 0.0 0.0028490028490028 npcB; 4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, reductase component path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 168.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG1853 FMN_reductase_RutF,_DIM6/NTAB_family RutF 2.0 0.0 1.0 0 0 0 0 K21730 0.0 0.0142450142450142 otemo; (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase [EC:1.14.13.160] 447.0 6.0 5.0 2.0 0.857142857142857 P 0.0 7.0 2.0 0.857142857142857 COG2072 Predicted_flavoprotein_CzcO_associated_with_the_cation_diffusion_facilitator_CzcD CzcO 7.0 0.0 1.0 0.0246336974939392 0.0583304635466283 0.0414820805202837 0.033696766052689 0 0 0 0 K21731 0.0 0.0085470085470085 camP; 2,5-diketocamphane 1,2-monooxygenase [EC:1.14.14.108] 349.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 3.0 0.0 1.0 0 0 0 0 K21739 0.0 0.0313390313390313 rclA; probable pyridine nucleotide-disulfide oxidoreductase 418.0 11.0 0.0 1.0 1.0 C 0.0 11.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 11.0 0.0 1.0 0.0966412499583063 0.169127671449353 0.1328844607038296 0.0724864214910467 0 0 0 0 K21741 0.0 0.0085470085470085 rclC; reactive chlorine resistance protein C 185.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG3059 Reactive_chlorine_resistance_protein_RclC/YkgB,_DUF417_family YkgB 3.0 0.0 1.0 0 0 0 0 K21742 0.0 0.0028490028490028 ttdR; LysR family transcriptional regulator, transcriptional activator for ttdABT operon 307.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K21744 0.0 0.0541310541310541 tipA; MerR family transcriptional regulator, thiopeptide resistance regulator 227.0 19.0 17.0 2.0 0.904761904761905 K 0.0 21.0 2.0 0.857142857142857 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 21.0 0.0 1.0 0.0124948449110585 0.042648099881108 0.0275714723960832 0.0301532549700495 0 0 0 0 K21745 0.0 0.0028490028490028 adhR; MerR family transcriptional regulator, aldehyde-responsive regulator 115.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 1.0 0.0 1.0 0 0 0 0 K21746 0.0 0.0028490028490028 rclR; AraC family transcriptional regulator, reactive chlorine species (RCS)-specific activator of rcl operon 284.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K21747 0.0 0.0028490028490028 alkR; AraC family transcriptional regulator, alkane utilization regulator 307.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K21748 0.0 0.0056980056980056 alkS; LuxR family transcriptional regulator, alkane degradation pathway regulator 845.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2909 ATP-,_maltotriose-_and_DNA-dependent_transcriptional_regulator_MalT MalT 2.0 0.0 1.0 0 0 0 0 K21749 0.0057142857142857 0.0313390313390313 CMAS; N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase [EC:2.7.7.43 2.7.7.92] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 12.0 11.0 5.0 2.0 0.647058823529412 M 2.0 13.0 2.0 0.647058823529412 COG1083 CMP-N-acetylneuraminic_acid_synthetase,_NeuA/PseF_family NeuA 15.0 0.1333333333333333 0.8666666666666667 0.10998242022178 0.170873311978325 0.1404278661000525 0.060890891756545 0 0 0 0 K21750 0.0 0.0113960113960113 E2.7.7.92; 3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase [EC:2.7.7.92] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 190.0 4.0 0.0 1.0 1.0 M 0.0 4.0 1.0 1.0 COG1861 Spore_coat_polysaccharide_biosynthesis_protein_SpsF,_cytidylyltransferase_family SpsF 4.0 0.0 1.0 0.103060210377303 0.194705628953621 0.148882919665462 0.091645418576318 0 0 0 0 K21755 0.0 0.037037037037037 bsdA; LysR family transcriptional regulator, salicylic acid-responsive activator of bsdBCD 257.0 14.0 0.0 1.0 1.0 K 0.0 14.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 14.0 0.0 1.0 0.0109436948644347 0.0956567105158161 0.0533002026901254 0.0847130156513814 0 0 0 0 K21756 0.0 0.0056980056980056 catM; LysR family transcriptional regulator, cis,cis-muconate-responsive activator of cat and ben genes 299.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 2.0 0.0 1.0 0 0 0 0 K21757 0.0 0.0455840455840455 benM; LysR family transcriptional regulator, benzoate and cis,cis-muconate-responsive activator of ben and cat genes 273.0 21.0 0.0 1.0 1.0 K 0.0 21.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 21.0 0.0 1.0 0.0088230749252676 0.0173664282879853 0.0130947516066264 0.0085433533627176 0 0 0 0 K21759 0.0028571428571428 0.0056980056980056 bsdD; vanillate/4-hydroxybenzoate decarboxylase subunit D [EC:4.1.1.- 4.1.1.61] path:map00627,path:map01120,path:map01220 Aminobenzoate degradation,Microbial metabolism in diverse environments,Degradation of aromatic compounds 35.0 3.0 0.0 1.0 1.0 S 1.0 3.0 2.0 0.75 2CK9M 4.0 0.25 0.75 3.50262557219905e-12 7.1796119491120695e-12 5.34111876065556e-12 3.67698637691302e-12 0 0 0 0 K21779 0.0028571428571428 0.0028490028490028 pigB; 2-methyl-3-n-amyl-dihydropyrrolel dehydrogenase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 349.0 2.0 0.0 1.0 1.0 H 1.0 1.0 1.0 1.0 COG1232 Protoporphyrinogen_oxidase_HemY/PPOX HemY 2.0 0.5 0.5 0 0 0 0 K21782 0.0 0.0028490028490028 pigA, redW; L-prolyl-PCP dehydrogenase [EC:1.3.8.14] path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 382.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 1.0 0.0 1.0 0 0 0 0 K21783 0.0 0.0056980056980056 pigJ, redX; beta-ketoacyl ACP synthase [EC:2.3.1.-] path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 591.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG0236 Acyl_carrier_protein AcpP 2.0 0.0 1.0 0 0 0 0 K21784 0.0 0.0028490028490028 pigH, redN; 4-hydroxy-2,2'-bipyrrole-5-methanol synthase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 461.0 1.0 0.0 1.0 1.0 E 0.0 1.0 1.0 1.0 COG0156 7-keto-8-aminopelargonate_synthetase_or_related_enzyme BioF 1.0 0.0 1.0 0 0 0 0 K21785 0.0 0.0056980056980056 pigM, redV; 4-hydroxy-2,2'-bipyrrole-5-methanol dehydrogenase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 322.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG0778 Nitroreductase NfnB 2.0 0.0 1.0 0 0 0 0 K21786 0.0028571428571428 0.0113960113960113 pigF, redI; 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1.-] path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 155.0 3.0 2.0 3.0 0.6 AJ 1.0 4.0 2.0 0.6 COG4123 tRNA1(Val)_A37_N6-methylase_TrmN6 TrmN6 5.0 0.2 0.8 0.305073844531616 0.206940973965196 0.256007409248406 0.09813287056642 0 0 0 0 K21787 0.0028571428571428 0.017094017094017 pigC, redH; prodigiosin/undecylprodigiosin synthetase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 390.0 3.0 0.0 3.0 0.428571428571429 GT 1.0 6.0 1.0 1.0 COG0574 Phosphoenolpyruvate_synthase/pyruvate_phosphate_dikinase PpsA 7.0 0.1428571428571428 0.8571428571428571 0.0277035376279731 0.0665703993863016 0.0471369685071373 0.0388668617583285 0 0 0 0 K21788 0.0 0.0028490028490028 redP; dodecanoy-ACP synthase path:map00333,path:map01110 Prodigiosin biosynthesis,Biosynthesis of secondary metabolites 342.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 1.0 0.0 1.0 0 0 0 0 K21789 0.0 0.0028490028490028 redR; dodecanoy-ACP synthase path:map00333,path:map01110 Prodigiosin biosynthesis,Biosynthesis of secondary metabolites 426.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG0304 3-oxoacyl-(acyl-carrier-protein)_synthase FabB 1.0 0.0 1.0 0 0 0 0 K21792 0.0028571428571428 0.0028490028490028 redL; polyketide synthase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 277.0 1.0 0.0 2.0 0.5 IQ 1.0 1.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 2.0 0.5 0.5 0 0 0 0 K21793 0.0 0.0085470085470085 redK; oxidoreductase path:map00333,path:map01100,path:map01110 Prodigiosin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 301.0 2.0 1.0 2.0 0.666666666666667 M 0.0 3.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 3.0 0.0 1.0 0 0 0 0 K21801 0.0 0.0142450142450142 iaaH; indoleacetamide hydrolase [EC:3.5.1.-] path:map00380,path:map01100 Tryptophan metabolism,Metabolic pathways 436.0 5.0 0.0 1.0 1.0 J 0.0 5.0 1.0 1.0 COG0154 Asp-tRNAAsn/Glu-tRNAGln_amidotransferase_A_subunit_or_related_amidase GatA 5.0 0.0 1.0 0.370351799113746 0.49405275249812 0.4322022758059329 0.1237009533843739 0 0 0 0 K21802 0.0 0.0341880341880341 vdh; vanillin dehydrogenase [EC:1.2.1.67] path:map00627,path:map01120 Aminobenzoate degradation,Microbial metabolism in diverse environments 469.0 16.0 0.0 1.0 1.0 C 0.0 16.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 16.0 0.0 1.0 0.0457688074746043 0.0885456932474694 0.0671572503610368 0.0427768857728651 0 0 0 0 K21814 0.0 0.0028490028490028 CPPED1; serine/threonine-protein phosphatase CPPED1 [EC:3.1.3.16] 281.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG1409 3',5'-cyclic_AMP_phosphodiesterase_CpdA CpdA 1.0 0.0 1.0 0 0 0 0 K21815 0.0 0.0056980056980056 efe; 2-oxoglutarate dioxygenase / 2-oxoglutarate/L-arginine monooxygenase/decarboxylase [EC:1.13.12.19 1.14.20.7] 296.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG3491 Isopenicillin_N_synthase_and_related_dioxygenases PcbC 2.0 0.0 1.0 0 0 0 0 K21816 0.0514285714285714 0.0028490028490028 fsr; sulfite reductase (coenzyme F420) [EC:1.8.98.3] 306.0 22.0 0.0 1.0 1.0 C 20.0 2.0 1.0 1.0 COG2221 Dissimilatory_sulfite_reductase_(desulfoviridin),_alpha_and_beta_subunits DsrA 22.0 0.9090909090909092 0.0909090909090909 0.33387602712962 0.231491148181724 0.282683587655672 0.102384878947896 0 0 0 0 K21817 0.0771428571428571 0.0227920227920227 blh; beta-carotene 15,15'-dioxygenase [EC:1.13.11.63] 258.0 42.0 41.0 3.0 0.954545454545455 C 36.0 8.0 5.0 0.590909090909091 arCOG02947 44.0 0.8181818181818182 0.1818181818181818 0.0189646570253903 0.0570035973427715 0.0379841271840809 0.0380389403173812 0 0 0 0 K21822 0.0 0.0028490028490028 E1.13.11.82; 8'-apo-carotenoid 13,14-cleaving dioxygenase [EC:1.13.11.82] 485.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG3670 Carotenoid_cleavage_dioxygenase_or_a_related_enzyme 1.0 0.0 1.0 0 0 0 0 K21825 0.0 0.0028490028490028 argR; AraC family transcriptional regulator, L-arginine-responsive activator 325.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG4977 Transcriptional_regulator_GlxA,_contains_an_amidase_domain_and_an_AraC-type_DNA-binding_HTH_domain GlxA 1.0 0.0 1.0 0 0 0 0 K21826 0.0 0.0398860398860398 gbdR; AraC family transcriptional regulator, glycine betaine-responsive activator 300.0 22.0 0.0 1.0 1.0 K 0.0 22.0 2.0 0.954545454545455 COG4977 Transcriptional_regulator_GlxA,_contains_an_amidase_domain_and_an_AraC-type_DNA-binding_HTH_domain GlxA 22.0 0.0 1.0 0.0047848640071082 0.0122370933321551 0.0085109786696316 0.0074522293250468 0 0 0 0 K21827 0.0628571428571428 0.0 arcR; IclR family transcriptional regulator, arginine deiminase pathway regulator 248.0 34.0 0.0 1.0 1.0 K 34.0 0.0 1.0 1.0 COG1414 DNA-binding_transcriptional_regulator,_IclR_family IclR 34.0 1.0 0.0 0.0102576452435164 0.0116932125676976 0.010975428905607 0.0014355673241811 0 0 0 0 K21828 0.0 0.017094017094017 arcR; CRP/FNR family transcriptional regulator, arginine deiminase pathway regulator 225.0 5.0 4.0 2.0 0.833333333333333 K 0.0 6.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 6.0 0.0 1.0 8.68919322133269e-07 0.0007316801417757 0.0003662745305489 0.0007308112224535 0 0 0 0 K21829 0.0 0.0113960113960113 dauR; D-arginine utilization repressor 196.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 COG2964 Predicted_transcriptional_regulator_YheO,_contains_PAS_and_DNA-binding_HTH_domains YheO 5.0 0.0 1.0 0.0205249890380731 0.0468346020740228 0.0336797955560479 0.0263096130359496 0 0 0 0 K21830 0.0 0.0085470085470085 pchP; phosphorylcholine phosphatase 200.0 3.0 0.0 1.0 1.0 E 0.0 3.0 1.0 1.0 COG0560 Phosphoserine_phosphatase SerB 3.0 0.0 1.0 0 0 0 0 K21831 0.0 0.0028490028490028 choE; cholinesterase 331.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG3240 Phospholipase/lecithinase/hemolysin 1.0 0.0 1.0 0 0 0 0 K21832 0.0142857142857142 0.0911680911680911 gbcB, bmoB; glycine betaine monooxygenase B [EC:1.14.13.251] path:map00260 Glycine, serine and threonine metabolism 150.0 41.0 37.0 3.0 0.891304347826087 C 5.0 41.0 4.0 0.869565217391304 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 46.0 0.108695652173913 0.8913043478260869 0.039196889399606 0.0207875407343699 0.0299922150669879 0.0184093486652361 0 0 0 0 K21833 0.0 0.0512820512820512 dgcA, ddhC; N,N-dimethylglycine/sarcosine dehydrogenase [EC:1.5.7.3] path:map00260 Glycine, serine and threonine metabolism 605.0 19.0 0.0 1.0 1.0 C 0.0 19.0 4.0 0.842105263157895 COG0446 NADPH-dependent_2,4-dienoyl-CoA_reductase,_sulfur_reductase,_or_a_related_oxidoreductase FadH2 19.0 0.0 1.0 0.0544565340938899 0.0797184804110274 0.0670875072524586 0.0252619463171375 0 0 0 0 K21834 0.0171428571428571 0.0284900284900284 dgcB; N,N-dimethylglycine/sarcosine dehydrogenase ferredoxin subunit path:map00260 Glycine, serine and threonine metabolism 265.0 20.0 0.0 1.0 1.0 C 9.0 11.0 1.0 1.0 COG0247 Fe-S_cluster-containing_oxidoreductase,_includes_glycolate_oxidase_subunit_GlcF GlpC 20.0 0.45 0.55 0.507083339767476 0.403128070985523 0.4551057053764995 0.1039552687819529 0 1 0 1 K21835 0.0228571428571428 0.0 adf; secondary-alcohol dehydrogenase (coenzyme-F420) [EC:1.1.98.5] 138.0 11.0 0.0 1.0 1.0 C 11.0 0.0 1.0 1.0 COG2141 Flavin-dependent_oxidoreductase,_luciferase_family_(includes_alkanesulfonate_monooxygenase_SsuD_and_methylene_tetrahydromethanopterin_reductase) SsuD 11.0 1.0 0.0 0.0358611889960289 0.0625934326189658 0.0492273108074973 0.0267322436229369 0 0 0 0 K21836 0.02 0.0028490028490028 dld; D-lactate dehydrogenase (acceptor) [EC:1.1.99.6] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 430.0 8.0 0.0 1.0 1.0 C 7.0 1.0 1.0 1.0 COG0277 FAD/FMN-containing_lactate_dehydrogenase/glycolate_oxidase GlcD 8.0 0.875 0.125 0.0198966413534792 0.0312990615704816 0.0255978514619804 0.0114024202170024 0 0 0 0 K21867 0.0 0.0028490028490028 AKT, KAT, GORK, SKOR; potassium channel 123.0 1.0 0.0 1.0 1.0 U 0.0 1.0 1.0 1.0 KOG0498 1.0 0.0 1.0 0 0 0 0 K21883 0.0 0.0797720797720797 lra5; 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) [EC:1.1.1.401] path:map00051,path:map01100,path:map01120 Fructose and mannose metabolism,Metabolic pathways,Microbial metabolism in diverse environments 202.0 37.0 35.0 2.0 0.948717948717949 IQ 0.0 39.0 3.0 0.897435897435898 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 39.0 0.0 1.0 0.0023576068881455 0.0083782138572098 0.0053679103726776 0.0060206069690643 0 0 0 0 K21884 0.0 0.0085470085470085 cmr; CRP/FNR family transcriptional regulator, cAMP and macrophage regulator 205.0 3.0 2.0 2.0 0.75 T 0.0 4.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 4.0 0.0 1.0 0.0152511590710116 3.57227835228317e-12 0.0076255795372919 0.0152511590674393 0 0 0 0 K21885 0.0057142857142857 0.037037037037037 cmtR; ArsR family transcriptional regulator, cadmium/lead-responsive transcriptional repressor 99.0 16.0 0.0 1.0 1.0 K 2.0 16.0 2.0 0.888888888888889 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 18.0 0.1111111111111111 0.8888888888888888 0.0396987878916492 0.0115487068609996 0.0256237473763243 0.0281500810306495 0 0 0 0 K21886 0.0028571428571428 0.0227920227920227 nmtR; ArsR family transcriptional regulator, nickel/cobalt-responsive transcriptional repressor 102.0 10.0 0.0 1.0 1.0 K 1.0 9.0 1.0 1.0 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 10.0 0.1 0.9 0.0163676983402688 0.0550399854185949 0.0357038418794318 0.0386722870783261 0 0 0 0 K21887 0.0 0.0284900284900284 ctpJ, nmtA; cation-transporting P-type ATPase J [EC:7.2.2.-] 589.0 13.0 0.0 1.0 1.0 P 0.0 13.0 1.0 1.0 COG2217 Cation-transporting_P-type_ATPase ZntA 13.0 0.0 1.0 0.009284646048981 0.0246996129957613 0.0169921295223711 0.0154149669467802 0 0 0 0 K21898 0.0 0.0484330484330484 orr; ornithine racemase [EC:5.1.1.12] path:map00470,path:map00997,path:map01100,path:map01110 D-Amino acid metabolism,Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 344.0 19.0 0.0 1.0 1.0 E 0.0 19.0 2.0 0.947368421052632 COG3457 Predicted_amino_acid_racemase YhfX 19.0 0.0 1.0 0.634018740749442 0.164790488137393 0.3994046144434174 0.469228252612049 0 0 0 1 K21900 0.0028571428571428 0.0398860398860398 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon 216.0 16.0 15.0 2.0 0.941176470588235 K 1.0 16.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 17.0 0.0588235294117647 0.9411764705882352 0.0321939911142138 0.239947031439105 0.1360705112766594 0.2077530403248912 0 0 0 0 K21901 0.0 0.0085470085470085 dctR; LuxR family transcriptional regulator, dicarboxylate transport regulator 111.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG2197 DNA-binding_response_regulator,_NarL/FixJ_family,_contains_REC_and_HTH_domains CitB 3.0 0.0 1.0 0 0 0 0 K21902 0.0028571428571428 0.0113960113960113 yfmP; MerR family transcriptional regulator, repressor of the yfmOP operon 131.0 5.0 0.0 1.0 1.0 K 1.0 4.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 5.0 0.2 0.8 0.039334628432823 0.0919569633162675 0.0656457958745452 0.0526223348834445 0 0 0 0 K21903 0.2914285714285714 0.3903133903133903 cadC, smtB; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor 33.0 337.0 0.0 1.0 1.0 K 155.0 183.0 2.0 0.997041420118343 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 338.0 0.4585798816568047 0.5414201183431953 0.371596789069058 0.533426774013375 0.4525117815412165 0.161829984944317 0 0 0 0 K21904 0.0 0.0113960113960113 smtA; metallothionein 53.0 5.0 0.0 1.0 1.0 S 0.0 5.0 1.0 1.0 2C300 5.0 0.0 1.0 2.78513586364674e-05 0.0003231299810749 0.0001754906698556 0.0002952786224384 0 0 0 0 K21905 0.0 0.0028490028490028 gadX; AraC family transcriptional regulator, glutamate-dependent acid resistance regulator 274.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 1.0 0.0 1.0 0 0 0 0 K21906 0.0 0.0028490028490028 gadW; AraC family transcriptional regulator, glutamate-dependent acid resistance regulator 239.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2207 AraC-type_DNA-binding_domain_and_AraC-containing_proteins AraC 2.0 0.0 1.0 0 0 0 0 K21907 0.0 0.0056980056980056 gadE; LuxR family transcriptional regulator, glutamate-dependent acid resistance regulator 166.0 2.0 0.0 1.0 1.0 K 0.0 2.0 1.0 1.0 COG2771 DNA-binding_transcriptional_regulator,_CsgD_family CsgD 2.0 0.0 1.0 0 0 0 0 K21908 0.0 0.0085470085470085 hdeD; membrane protein HdeD 88.0 2.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 COG3247 Acid_resistance_membrane_protein_HdeD,_DUF308_family HdeD 3.0 0.0 1.0 0 0 0 0 K21909 0.0142857142857142 0.0227920227920227 eryC; D-erythrulose 1-phosphate 3-epimerase [EC:5.1.3.38] 295.0 13.0 0.0 1.0 1.0 G 5.0 8.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 13.0 0.3846153846153846 0.6153846153846154 0.993060111927725 0.440751932979733 0.716906022453729 0.552308178947992 1 1 1 1 K21910 0.0 0.0199430199430199 eryH, lerI; L-erythrulose 1-phosphate isomerase [EC:5.3.1.33] 247.0 8.0 0.0 1.0 1.0 G 0.0 8.0 1.0 1.0 COG0149 Triosephosphate_isomerase TpiA 8.0 0.0 1.0 0.382923365274482 0.187198629683066 0.285060997478774 0.195724735591416 0 0 0 0 K21911 0.0 0.0113960113960113 eryI; D-erythrulose 4-phosphate isomerase [EC:5.3.1.34] 150.0 4.0 0.0 1.0 1.0 G 0.0 4.0 1.0 1.0 COG0698 Ribose_5-phosphate_isomerase_RpiB RpiB 4.0 0.0 1.0 0.0556957970392808 0.111118435338573 0.0834071161889269 0.0554226382992922 0 0 0 0 K21912 0.0 0.0028490028490028 KBTBD12; kelch repeat and BTB domain-containing protein 12 141.0 1.0 0.0 1.0 1.0 T 0.0 1.0 1.0 1.0 KOG4441 1.0 0.0 1.0 0 0 0 0 K21919 0.0 0.0085470085470085 KCTD9; BTB/POZ domain-containing protein KCTD9 158.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 COG1357 Uncharacterized_conserved_protein_YjbI,_contains_pentapeptide_repeats YjbI 3.0 0.0 1.0 0 0 0 0 K21929 0.6085714285714285 0.7037037037037037 udg; uracil-DNA glycosylase [EC:3.2.2.27] path:map03410 Base excision repair 13.0 698.0 697.0 2.0 0.998569384835479 L 335.0 352.0 4.0 0.971387696709585 COG1573 Uracil-DNA_glycosylase Udg4 687.0 0.487627365356623 0.512372634643377 0.0213147913439607 0.552917975681681 0.2871163835128208 0.5316031843377202 0 0 0 0 K21935 0.0285714285714285 0.0427350427350427 ablB; beta-lysine N6-acetyltransferase [EC:2.3.1.264] 216.0 15.0 8.0 4.0 0.6 K 10.0 15.0 3.0 0.56 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 25.0 0.4 0.6 0.0131276512000191 0.0337056342319819 0.0234166427160005 0.0205779830319627 0 0 0 0 K21936 0.0 0.0284900284900284 chuW; anaerobilin synthase [EC:2.1.1.342] 420.0 6.0 3.0 3.0 0.545454545454545 H 0.0 11.0 1.0 1.0 COG0635 Coproporphyrinogen-III_oxidase_HemN__(oxygen-independent)_or_related_Fe-S_oxidoreductase HemN 11.0 0.0 1.0 0.0263129323279051 0.0659156031412785 0.0461142677345918 0.0396026708133734 0 0 0 0 K21947 0.2714285714285714 0.0826210826210826 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15] 182.0 97.0 47.0 3.0 0.633986928104575 D 118.0 35.0 2.0 0.869281045751634 COG0037 tRNA(Ile)-lysidine_synthase_TilS/MesJ TilS 153.0 0.7712418300653595 0.2287581699346405 0.961796796405617 0.840539711147033 0.901168253776325 0.121257085258584 1 1 1 1 K21948 0.0 0.0455840455840455 otnK; 3-dehydrotetronate 4-kinase [EC:2.7.1.217] 409.0 16.0 0.0 1.0 1.0 S 0.0 16.0 1.0 1.0 COG3395 D-threonate/D-erythronate_kinase_OtnK_and_related_C4-acid_sugar_kinases,_YgbK/DUF1537_family OtnK 16.0 0.0 1.0 0.0320980161907238 0.104332517757354 0.0682152669740389 0.0722345015666302 0 0 0 0 K21949 0.0 0.0398860398860398 sbnA; N-(2-amino-2-carboxyethyl)-L-glutamate synthase [EC:2.5.1.140] path:map00997,path:map00998,path:map01100,path:map01110 Biosynthesis of various other secondary metabolites; Including: Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis,Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 293.0 16.0 15.0 2.0 0.941176470588235 E 0.0 17.0 1.0 1.0 COG0031 Cysteine_synthase CysK 17.0 0.0 1.0 0.0124950647472545 0.039822842486543 0.0261589536168987 0.0273277777392884 0 0 0 0 K21957 0.0 0.0028490028490028 FAM20A; pseudokinase FAM20A 402.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG3829 1.0 0.0 1.0 0 0 0 0 K21958 0.0 0.0028490028490028 FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1] 402.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 KOG3829 1.0 0.0 1.0 0 0 0 0 K21960 0.0 0.0028490028490028 ytlI; LysR family transcriptional regulator, regulator of the ytmI operon 311.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0583 DNA-binding_transcriptional_regulator,_LysR_family LysR 1.0 0.0 1.0 0 0 0 0 K21961 0.0 0.017094017094017 ethR, etaR; TetR/AcrR family transcriptional regulator, ethionamide resistance regulator 190.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 7.0 0.0 1.0 0.0191303839335623 0.105227421829431 0.0621789028814966 0.0860970378958687 0 0 0 0 K21962 0.0 0.0199430199430199 acnR; TetR/AcrR family transcriptional regulator, transcriptional repressor of aconitase 187.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 7.0 0.0 1.0 1.01129738835858e-21 4.03658750904479e-11 2.01829375457296e-11 4.03658750894366e-11 0 0 0 0 K21963 0.0 0.0113960113960113 ecpR, matA; LuxR family transcriptional regulator, Mat/Ecp fimbriae transcriptional regulator 122.0 4.0 0.0 1.0 1.0 K 0.0 4.0 2.0 0.5 COG2771 DNA-binding_transcriptional_regulator,_CsgD_family CsgD 4.0 0.0 1.0 0.0405270632264822 0.0923169968196313 0.0664220300230567 0.0517899335931491 0 0 0 0 K21964 0.0 0.0028490028490028 ecpA, matB; Mat/Ecp fimbriae major subunit 195.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28JUN 1.0 0.0 1.0 0 0 0 0 K21965 0.0 0.0028490028490028 ecpB, matC; Mat/Ecp fimbriae periplasmic chaperone 222.0 1.0 0.0 1.0 1.0 M 0.0 1.0 1.0 1.0 COG3121 P_pilus_assembly_protein,_chaperone_PapD FimC 1.0 0.0 1.0 0 0 0 0 K21966 0.0 0.0085470085470085 ecpC, matD; Mat/Ecp fimbriae outer membrane usher protein 242.0 3.0 0.0 1.0 1.0 NU 0.0 3.0 1.0 1.0 COG3188 Outer_membrane_usher_protein_FimD/PapC FimD 3.0 0.0 1.0 0 0 0 0 K21967 0.0 0.0028490028490028 ecpD, matE; Mat/Ecp fimbriae adhesin 547.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28J32 1.0 0.0 1.0 0 0 0 0 K21968 0.0 0.0028490028490028 ecpE, matF; Mat/Ecp fimbriae periplasmic chaperone 236.0 1.0 0.0 1.0 1.0 NU 0.0 1.0 1.0 1.0 COG3121 P_pilus_assembly_protein,_chaperone_PapD FimC 1.0 0.0 1.0 0 0 0 0 K21970 0.0 0.0113960113960113 NSUN4; 5-methylcytosine rRNA methyltransferase NSUN4 [EC:2.1.1.-] 225.0 4.0 0.0 1.0 1.0 J 0.0 4.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 4.0 0.0 1.0 1.34847992871079e-11 1.10784557550752e-07 5.539902117501956e-08 1.1077107275146488e-07 0 0 0 0 K21972 0.0 0.017094017094017 bluR; MerR family transcriptional regulator, repressor of blue light- and temperature-responsive genes 160.0 5.0 3.0 2.0 0.714285714285714 K 0.0 7.0 1.0 1.0 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 7.0 0.0 1.0 0.0278438595206756 0.0625293974739788 0.0451866284973272 0.0346855379533032 0 0 0 0 K21973 0.0 0.0113960113960113 bluF; blue light- and temperature-responsive anti-repressor 27.0 4.0 0.0 1.0 1.0 T 0.0 4.0 1.0 1.0 COG2200 EAL_domain,_c-di-GMP-specific_phosphodiesterase_class_I_(or_its_enzymatically_inactive_variant) EAL 4.0 0.0 1.0 0.0315871485394095 0.0771959276414721 0.0543915380904408 0.0456087791020626 0 0 0 0 K21974 0.0 0.0056980056980056 ycgZ; probable RcsB/C two-component-system connector 67.0 3.0 0.0 1.0 1.0 S 0.0 3.0 2.0 0.666666666666667 2CBKZ 3.0 0.0 1.0 0 0 0 0 K21975 0.0 0.0028490028490028 ymgA; probable RcsB/C two-component-system connector 97.0 0.0 1.0 1.0 1.0 2DTRW 1.0 0.0 1.0 0 0 0 0 K21976 0.0 0.0028490028490028 ariR; probable RcsB/C two-component-system connector, global regulator of biofilm formation and acid-resistance 88.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 2ECN4 1.0 0.0 1.0 0 0 0 0 K21977 0.0 0.0911680911680911 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5] path:map00770,path:map01240 Pantothenate and CoA biosynthesis,Biosynthesis of cofactors 173.0 32.0 0.0 1.0 1.0 H 0.0 32.0 1.0 1.0 COG0452 Phosphopantothenoylcysteine_synthetase/decarboxylase_CoaBC CoaBC 32.0 0.0 1.0 0.0112116279064952 0.0358222579392938 0.0235169429228945 0.0246106300327986 0 0 0 0 K21990 0.2571428571428571 0.074074074074074 yfdC; formate-nitrite transporter family protein 65.0 74.0 13.0 5.0 0.41340782122905 O 147.0 31.0 4.0 0.441340782122905 COG1651 Protein_thiol-disulfide_isomerase_DsbC DsbG 178.0 0.8258426966292135 0.1741573033707865 0.58601053102949 0.387894951781708 0.4869527414055989 0.1981155792477819 0 1 0 1 K21992 0.0 0.0085470085470085 mbtK; lysine N-acyltransferase [EC:2.3.1.-] 179.0 3.0 0.0 1.0 1.0 J 0.0 3.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 3.0 0.0 1.0 0 0 0 0 K21993 0.0742857142857142 0.1794871794871795 fdhC; formate transporter 193.0 96.0 95.0 2.0 0.989690721649485 P 29.0 68.0 3.0 0.979381443298969 COG2116 Formate/nitrite_transporter_FocA,_FNT_family FocA 97.0 0.2989690721649484 0.7010309278350515 0.514537512120114 0.536126320501223 0.5253319163106684 0.0215888083811089 0 1 0 1 K22003 0.0 0.017094017094017 ais; aconitate Delta-isomerase [EC:5.3.3.7] path:map00660,path:map01100 C5-Branched dibasic acid metabolism,Metabolic pathways 189.0 8.0 0.0 1.0 1.0 P 0.0 8.0 1.0 1.0 COG0725 ABC-type_molybdate_transport_system,_periplasmic_Mo-binding_protein_ModA ModA 8.0 0.0 1.0 0.0248695686549235 0.0554430056934363 0.0401562871741799 0.0305734370385128 0 0 0 0 K22010 0.0 0.2279202279202279 pdtaR; two-component system, response regulator PdtaR 140.0 82.0 70.0 3.0 0.863157894736842 T 0.0 95.0 6.0 0.926315789473684 COG3707 Two-component_response_regulator,_AmiR/NasT_family,_consists_of_REC_and_RNA-binding_antiterminator_(ANTAR)_domains AmiR 95.0 0.0 1.0 0.15388200478747 0.16926732681458 0.161574665801025 0.01538532202711 0 0 0 0 K22011 0.1857142857142857 0.0028490028490028 cfbA; sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 99.0 74.0 71.0 2.0 0.961038961038961 H 76.0 1.0 1.0 1.0 COG2138 Sirohydrochlorin_ferrochelatase SirB 77.0 0.987012987012987 0.0129870129870129 0.223169313414051 0.130190954636399 0.1766801340252249 0.092978358777652 0 0 0 0 K22012 0.14 0.0 cfbB; Ni-sirohydrochlorin a,c-diamide synthase [EC:6.3.5.12] path:map00860,path:map01100,path:map01110,path:map01120,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Biosynthesis of cofactors 380.0 50.0 0.0 1.0 1.0 H 50.0 0.0 1.0 1.0 COG1797 Cobyrinic_acid_a,c-diamide_synthase CobB 50.0 1.0 0.0 0.715924425532563 0.768061751128005 0.741993088330284 0.052137325595442 0 0 0 1 K22014 0.0 0.0113960113960113 Nu1, Noh; Escherichia phage terminase small subunit, DNA-packaing protein 84.0 3.0 0.0 1.0 1.0 L 0.0 5.0 2.0 0.6 COG4220 Phage_DNA_packaging_protein,_Nu1_subunit_of_terminase Nu1 5.0 0.0 1.0 1.45807397788033e-11 0.435574856216018 0.2177874281152993 0.4355748562014372 0 0 0 0 K22015 0.0 0.0 fdhF; formate dehydrogenase (hydrogenase) [EC:1.17.98.4 1.17.98.-] path:map00680,path:map00720,path:map01100,path:map01120,path:map01200 Methane metabolism,Carbon fixation pathways in prokaryotes,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 14.0 0.0 1.0 1.0 C 0.0 0.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 0.0 0 0 0 0 K22024 0.0485714285714285 0.2564102564102564 pdxA2; 4-phospho-D-threonate 3-dehydrogenase / 4-phospho-D-erythronate 3-dehydrogenase [EC:1.1.1.408 1.1.1.409] 224.0 77.0 38.0 2.0 0.663793103448276 H 18.0 98.0 1.0 1.0 COG1995 4-hydroxy-L-threonine_phosphate_dehydrogenase_PdxA PdxA 116.0 0.1551724137931034 0.8448275862068966 0.214244104400036 0.324018626589388 0.269131365494712 0.109774522189352 0 0 0 0 K22025 0.0 0.0484330484330484 denD; D-erythronate 2-dehydrogenase [EC:1.1.1.410] 312.0 10.0 1.0 2.0 0.526315789473684 M 0.0 19.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 19.0 0.0 1.0 0.0230215450685659 0.0476432535878158 0.0353323993281908 0.0246217085192499 0 0 0 0 K22026 0.1857142857142857 0.017094017094017 K22026; nucleoside kinase [EC:2.7.1.73 2.7.1.213 2.7.1.-] path:map00230,path:map00240,path:map01100,path:map01232 Purine metabolism,Pyrimidine metabolism,Metabolic pathways,Nucleotide metabolism 163.0 61.0 47.0 2.0 0.813333333333333 G 68.0 7.0 1.0 1.0 COG0524 Sugar_or_nucleoside_kinase,_ribokinase_family RbsK 75.0 0.9066666666666666 0.0933333333333333 0.879967369198369 0.962315235796302 0.9211413024973356 0.0823478665979329 1 1 1 1 K22027 0.0 0.0427350427350427 iacA; indole-3-acetate monooxygenase [EC:1.14.13.235] 332.0 22.0 0.0 1.0 1.0 I 0.0 22.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 22.0 0.0 1.0 0.0022628368046277 0.0160755559330605 0.009169196368844 0.0138127191284327 0 0 0 0 K22033 0.0 0.0199430199430199 K22033; lytic cellulose monooxygenase (C4-dehydrogenating) [EC:1.14.99.56] 201.0 7.0 2.0 2.0 0.583333333333333 S 0.0 12.0 1.0 1.0 COG3397 Predicted_carbohydrate-binding_protein,_contains_CBM5_and_CBM33_domains 12.0 0.0 1.0 1.52584215954269e-05 0.000195706270061 0.0001054823458282 0.0001804478484655 0 0 0 0 K22041 0.0 0.0142450142450142 comR; TetR/AcrR family transcriptional regulator, copper-responsive repressor 190.0 5.0 0.0 1.0 1.0 K 0.0 5.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 5.0 0.0 1.0 0.030866077403324 0.0638636188924458 0.0473648481478849 0.0329975414891217 0 0 0 0 K22042 0.0 0.0484330484330484 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator 81.0 21.0 20.0 2.0 0.954545454545455 K 0.0 22.0 1.0 1.0 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 22.0 0.0 1.0 0.0202325578581631 0.0395406045124396 0.0298865811853013 0.0193080466542764 0 0 0 0 K22043 0.0485714285714285 0.0598290598290598 czrA; ArsR family transcriptional regulator, zinc-responsive transcriptional repressor 67.0 44.0 0.0 1.0 1.0 K 18.0 26.0 1.0 1.0 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 44.0 0.4090909090909091 0.5909090909090909 0.0295280220123975 0.114048134537616 0.0717880782750067 0.0845201125252185 0 0 0 0 K22044 0.0371428571428571 0.3988603988603988 ybiO; moderate conductance mechanosensitive channel 126.0 189.0 0.0 1.0 1.0 M 14.0 175.0 3.0 0.968253968253968 COG0668 Small-conductance_mechanosensitive_channel MscS 189.0 0.074074074074074 0.925925925925926 0.0144043079516904 0.326560328286131 0.1704823181189107 0.3121560203344406 0 0 0 0 K22051 0.0514285714285714 0.0797720797720797 mscM, bspA; miniconductance mechanosensitive channel 168.0 43.0 41.0 5.0 0.877551020408163 M 18.0 31.0 9.0 0.63265306122449 COG3264 Small-conductance_mechanosensitive_channel_MscK MscK 49.0 0.3673469387755102 0.6326530612244898 0.920067997680638 0.647112991172662 0.78359049442665 0.272955006507976 1 1 1 1 K22063 0.0 0.0056980056980056 ISCA1; iron-sulfur cluster assembly 1 107.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 2.0 0.0 1.0 0 0 0 0 K22066 0.0 0.0797720797720797 BOLA1; BolA-like protein 1 85.0 28.0 0.0 1.0 1.0 T 0.0 28.0 1.0 1.0 COG0271 DNA-binding_global_transcriptional_regulator_BolA,_affects_cell_shape,_cell_division_and_biofilm_formation BolA 28.0 0.0 1.0 0.0022190859793715 0.0064135820830953 0.0043163340312334 0.0041944961037237 0 0 0 0 K22067 0.0 0.0569800569800569 nasS; two-component system, oxyanion-binding sensor 315.0 23.0 0.0 1.0 1.0 P 0.0 23.0 1.0 1.0 COG0715 ABC-type_nitrate/sulfonate/bicarbonate_transport_system,_periplasmic_component TauA 23.0 0.0 1.0 0.0099063666171199 0.0172372762690206 0.0135718214430702 0.0073309096519007 0 0 0 0 K22071 0.0 0.0028490028490028 FDX2; ferredoxin-2, mitochondrial 101.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0633 Ferredoxin Fdx 1.0 0.0 1.0 0 0 0 0 K22072 0.0028571428571428 0.0028490028490028 ISCA2; iron-sulfur cluster assembly 2 146.0 2.0 0.0 1.0 1.0 CU 1.0 1.0 1.0 1.0 COG0316 Fe-S_cluster_assembly_iron-binding_protein_IscA IscA 2.0 0.5 0.5 0 0 0 0 K22073 0.0 0.037037037037037 IBA57; transferase CAF17, mitochondrial [EC:2.1.-.-] 228.0 12.0 11.0 2.0 0.923076923076923 S 0.0 13.0 1.0 1.0 COG0354 Folate-binding_protein_YgfZ,_synthesis_and_repair_of_Fe-S_clusters YgfZ 13.0 0.0 1.0 3.68775322933898e-07 0.0067660148757509 0.0033831918255369 0.0067656461004279 0 0 0 0 K22074 0.0 0.0056980056980056 NFU1, HIRIP5; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial 78.0 2.0 0.0 1.0 1.0 O 0.0 2.0 1.0 1.0 COG0694 Fe-S_cluster_biogenesis_protein_NfuA,_4Fe-4S-binding_domain NifU 2.0 0.0 1.0 0 0 0 0 K22081 0.0 0.0598290598290598 mgsA; methylamine---glutamate N-methyltransferase subunit A [EC:2.1.1.21] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 272.0 17.0 13.0 3.0 0.739130434782609 F 0.0 23.0 3.0 0.739130434782609 COG0034 Glutamine_phosphoribosylpyrophosphate_amidotransferase PurF 23.0 0.0 1.0 0.0780529986418399 0.0535273896487192 0.0657901941452795 0.0245256089931207 0 0 0 0 K22082 0.0 0.0626780626780626 mgsB; methylamine---glutamate N-methyltransferase subunit B [EC:2.1.1.21] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 209.0 24.0 0.0 1.0 1.0 C 0.0 24.0 1.0 1.0 COG2218 Formylmethanofuran_dehydrogenase_subunit_C FwdC 24.0 0.0 1.0 0.0503082097139673 0.0851282605220793 0.0677182351180233 0.0348200508081119 0 0 0 0 K22083 0.0085714285714285 0.0854700854700854 mgsC; methylamine---glutamate N-methyltransferase subunit C [EC:2.1.1.21] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 383.0 31.0 27.0 2.0 0.885714285714286 E 3.0 32.0 2.0 0.971428571428571 COG0069 Glutamate_synthase_domain_2 GltB2 35.0 0.0857142857142857 0.9142857142857144 0.0230442228306978 0.0583077004755571 0.0406759616531274 0.0352634776448593 0 0 0 0 K22084 0.0 0.037037037037037 mgdA; methylglutamate dehydrogenase subunit A [EC:1.5.99.5] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 416.0 14.0 12.0 2.0 0.875 E 0.0 16.0 1.0 1.0 COG0665 Glycine/D-amino_acid_oxidase_(deaminating) DadA 16.0 0.0 1.0 0.0058583471331702 0.0233572777815331 0.0146078124573516 0.0174989306483629 0 0 0 0 K22085 0.0 0.0427350427350427 mgdB; methylglutamate dehydrogenase subunit B [EC:1.5.99.5] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 89.0 12.0 9.0 2.0 0.8 E 0.0 15.0 1.0 1.0 COG4311 Sarcosine_oxidase_delta_subunit SoxD 15.0 0.0 1.0 0.0101569928700124 0.0289983023410042 0.0195776476055083 0.0188413094709918 0 0 0 0 K22086 0.0028571428571428 0.0455840455840455 mgdC; methylglutamate dehydrogenase subunit C [EC:1.5.99.5] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 334.0 16.0 14.0 2.0 0.888888888888889 E 1.0 17.0 1.0 1.0 COG0404 Glycine_cleavage_system_protein_T_(aminomethyltransferase) GcvT 18.0 0.0555555555555555 0.9444444444444444 0.035309988373161 0.0604146934565075 0.0478623409148342 0.0251047050833464 0 0 0 0 K22087 0.0 0.0227920227920227 mgdD; methylglutamate dehydrogenase subunit D [EC:1.5.99.5] path:map00680,path:map01100,path:map01120 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments 138.0 8.0 0.0 1.0 1.0 E 0.0 8.0 1.0 1.0 COG4583 Sarcosine_oxidase_gamma_subunit SoxG 8.0 0.0 1.0 0.0152007098720285 0.032959852626516 0.0240802812492722 0.0177591427544875 0 0 0 0 K22099 0.0 0.0313390313390313 folC2; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 238.0 11.0 0.0 1.0 1.0 S 0.0 11.0 1.0 1.0 COG1478 F420-0:Gamma-glutamyl_ligase_(F420_biosynthesis) CofE 11.0 0.0 1.0 0.0117820876962999 0.622759366912131 0.3172707273042154 0.6109772792158311 0 0 0 0 K22100 0.0 0.017094017094017 trpF; 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 185.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG0135 Phosphoribosylanthranilate_isomerase TrpF 6.0 0.0 1.0 0.0643064391192582 0.180572014249638 0.1224392266844481 0.1162655751303798 0 0 0 0 K22101 0.0057142857142857 0.0 PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.1.2.60 4.2.3.12] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 136.0 2.0 0.0 1.0 1.0 H 2.0 0.0 1.0 1.0 COG0720 6-pyruvoyl-tetrahydropterin_synthase QueD 2.0 1.0 0.0 0 0 0 0 K22102 0.0342857142857142 0.0 E4.1.2.59; dihydroneopterin phosphate aldolase [EC:4.1.2.59] path:map00790,path:map01100 Folate biosynthesis,Metabolic pathways 101.0 12.0 0.0 1.0 1.0 H 12.0 0.0 1.0 1.0 COG0720 6-pyruvoyl-tetrahydropterin_synthase QueD 12.0 1.0 0.0 0.0019727802672358 0.0094611827269042 0.00571698149707 0.0074884024596684 0 0 0 0 K22103 0.0 0.0227920227920227 glcR; DeoR family transcriptional regulator, carbon catabolite repression regulator 242.0 11.0 0.0 1.0 1.0 K 0.0 11.0 1.0 1.0 COG1349 DNA-binding_transcriptional_regulator_of_sugar_metabolism,_DeoR/GlpR_family GlpR 11.0 0.0 1.0 0.0074570099060021 0.063205195219372 0.035331102562687 0.0557481853133699 0 0 0 0 K22104 0.0 0.0142450142450142 nanR; GntR family transcriptional regulator, sialic acid-inducible nan operon repressor 226.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG2186 DNA-binding_transcriptional_regulator,_FadR_family FadR 6.0 0.0 1.0 0.0182685539974432 0.0426378027109016 0.0304531783541723 0.0243692487134583 0 0 0 0 K22105 0.0 0.0341880341880341 fabR; TetR/AcrR family transcriptional regulator, fatty acid biosynthesis regulator 195.0 12.0 0.0 1.0 1.0 K 0.0 12.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 12.0 0.0 1.0 0.0062540636704385 0.0160828821440864 0.0111684729072624 0.0098288184736478 0 0 0 0 K22106 0.0 0.017094017094017 fatR, bscR; TetR/AcrR family transcriptional regulator, repressor of fatR-cypB operon 184.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 6.0 0.0 1.0 0.0216893131423098 0.0590585238383025 0.0403739184903061 0.0373692106959926 0 0 0 0 K22107 0.0 0.0341880341880341 kstR; TetR/AcrR family transcriptional regulator, cholesterol catabolism regulator 168.0 17.0 0.0 1.0 1.0 K 0.0 17.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 17.0 0.0 1.0 0.003449697334921 0.0116627865541584 0.0075562419445397 0.0082130892192373 0 0 0 0 K22108 0.0 0.0341880341880341 kstR2; TetR/AcrR family transcriptional regulator, cholesterol catabolism regulator 171.0 15.0 14.0 2.0 0.9375 K 0.0 16.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 16.0 0.0 1.0 0.0032410089416057 0.0065499662589034 0.0048954876002545 0.0033089573172977 0 0 0 0 K22109 0.0714285714285714 0.0227920227920227 gbsR; HTH-type transcriptional regulator, glycine betaine synthesis regulator 123.0 40.0 0.0 1.0 1.0 K 31.0 9.0 1.0 1.0 COG1510 DNA-binding_transcriptional_regulator_GbsR,_MarR_family GbsR 40.0 0.775 0.225 0.0305830454623277 0.337910306904031 0.1842466761831793 0.3073272614417033 0 0 0 0 K22110 0.0 0.0427350427350427 kdgM, kdgN, nanC, ompL; oligogalacturonate-specific porin family protein 110.0 16.0 0.0 1.0 1.0 M 0.0 16.0 2.0 0.5625 COG1452 LPS_assembly_outer_membrane_protein_LptD_(organic_solvent_tolerance_protein_OstA) LptD 16.0 0.0 1.0 0.048165205521037 0.0277636892137793 0.0379644473674081 0.0204015163072577 0 0 0 0 K22111 0.0 0.0028490028490028 nanS; 9-O-acetyl-N-acetylneuraminic acid deacetylase 326.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 2DDQI 1.0 0.0 1.0 0 0 0 0 K22112 0.0114285714285714 0.0199430199430199 amiS; putative amide transporter protein 166.0 8.0 3.0 2.0 0.615384615384615 S 4.0 9.0 1.0 1.0 29DTM 13.0 0.3076923076923077 0.6923076923076923 0.0463627217811913 0.128891169435034 0.0876269456081126 0.0825284476538427 0 0 0 0 K22116 0.0 0.0598290598290598 capC, pgsC; gamma-polyglutamate biosynthesis protein CapC 133.0 21.0 0.0 1.0 1.0 S 0.0 21.0 3.0 0.714285714285714 29EG8 21.0 0.0 1.0 0.0277627585636608 0.553156260745585 0.2904595096546229 0.5253935021819242 0 0 0 0 K22129 0.0371428571428571 0.1082621082621082 dtnK, denK; D-threonate/D-erythronate kinase [EC:2.7.1.219 2.7.1.220] 203.0 56.0 55.0 2.0 0.982456140350877 S 15.0 42.0 1.0 1.0 COG3395 D-threonate/D-erythronate_kinase_OtnK_and_related_C4-acid_sugar_kinases,_YgbK/DUF1537_family OtnK 57.0 0.2631578947368421 0.7368421052631579 0.0957532392294815 0.125772492112363 0.1107628656709222 0.0300192528828815 0 0 0 0 K22130 0.0 0.0712250712250712 otnC; 3-dehydro-4-phosphotetronate decarboxylase [EC:4.1.1.104] 174.0 23.0 18.0 3.0 0.793103448275862 G 0.0 29.0 1.0 1.0 COG0235 5-methylthioribulose/5-deoxyribulose/Fuculose_1-phosphate_aldolase_(methionine_salvage,_sugar_degradation) AraD 29.0 0.0 1.0 0.0274863210664136 0.0357699011144962 0.0316281110904549 0.0082835800480825 0 0 0 0 K22131 0.0 0.0655270655270655 otnI; 2-dehydrotetronate isomerase [EC:5.3.1.35] 225.0 29.0 0.0 1.0 1.0 G 0.0 29.0 1.0 1.0 COG3622 Hydroxypyruvate/dehydroerythronate_isomerase,_Hyi/OtnI_family Hyi 29.0 0.0 1.0 0.0219373844287788 0.0265438433017827 0.0242406138652807 0.0046064588730038 0 0 0 0 K22132 0.0428571428571428 0.2792022792022792 tcdA; tRNA threonylcarbamoyladenosine dehydratase 170.0 118.0 117.0 2.0 0.991596638655462 H 17.0 102.0 3.0 0.848739495798319 COG1179 tRNA_A37_threonylcarbamoyladenosine_dehydratase TcdA 119.0 0.1428571428571428 0.8571428571428571 0.0044975990148126 0.167765035809174 0.0861313174119933 0.1632674367943614 0 0 0 0 K22133 0.0028571428571428 0.0056980056980056 AAE3; oxalate---CoA ligase [EC:6.2.1.8] path:map00630,path:map01100 Glyoxylate and dicarboxylate metabolism,Metabolic pathways 78.0 3.0 0.0 1.0 1.0 IQ 1.0 2.0 1.0 1.0 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K22135 0.0085714285714285 0.0541310541310541 bshB2; N-acetylglucosamine malate deacetylase 2 [EC:3.5.1.-] 161.0 25.0 0.0 1.0 1.0 S 4.0 21.0 1.0 1.0 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 25.0 0.16 0.84 0.0329126081625661 0.37799382529405 0.205453216728308 0.3450812171314839 0 0 0 0 K22136 0.0228571428571428 0.1709401709401709 bshC; bacillithiol synthase 184.0 70.0 0.0 1.0 1.0 S 8.0 62.0 2.0 0.9 COG4365 Putative_cysteine_ligase_BshC/YllA_(bacillithiol_biosynthesis) BshC 70.0 0.1142857142857142 0.8857142857142857 0.0214894450261932 0.0333544965590347 0.0274219707926139 0.0118650515328414 0 0 0 0 K22144 0.0 0.0085470085470085 TEME2; cell surface hyaluronidase [EC:3.2.1.35] 626.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG3794 Plastocyanin PetE 3.0 0.0 1.0 0 0 0 0 K22158 0.0885714285714285 0.0 fpoA; F420H2 dehydrogenase subunit A [EC:1.5.98.3] 114.0 31.0 0.0 1.0 1.0 C 31.0 0.0 1.0 1.0 COG0838 NADH:ubiquinone_oxidoreductase_subunit_3_(chain_A) NuoA 31.0 1.0 0.0 0.125174045543554 0.0049580300600567 0.0650660378018053 0.1202160154834973 0 0 0 0 K22159 0.1428571428571428 0.0 fpoB; F420H2 dehydrogenase subunit B [EC:1.5.98.3] 151.0 50.0 0.0 1.0 1.0 C 50.0 0.0 1.0 1.0 COG0377 NADH:ubiquinone_oxidoreductase_20_kD_subunit_(chain_B)_or_related_Fe-S_oxidoreductase NuoB 50.0 1.0 0.0 0.321209006936241 0.0336310219340495 0.1774200144351452 0.2875779850021915 0 0 0 0 K22160 0.1142857142857142 0.0028490028490028 fpoC; F420H2 dehydrogenase subunit C [EC:1.5.98.3] 115.0 43.0 0.0 1.0 1.0 C 42.0 1.0 1.0 1.0 COG0852 NADH:ubiquinone_oxidoreductase_27_kD_subunit_(chain_C) NuoC 43.0 0.9767441860465116 0.0232558139534883 0.962422260161542 0.992423690687041 0.9774229754242916 0.0300014305254989 0 0 1 1 K22161 0.0428571428571428 0.0 fpoD; F420H2 dehydrogenase subunit D [EC:1.5.98.3] 365.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 15.0 1.0 0.0 0.0154373007811155 0.0014365658953472 0.0084369333382313 0.0140007348857683 0 0 0 0 K22162 0.04 0.0 fpoF; F420H2 dehydrogenase subunit F [EC:1.5.7.2 1.5.98.3] 306.0 14.0 0.0 1.0 1.0 C 14.0 0.0 1.0 1.0 COG1035 Coenzyme_F420-reducing_hydrogenase,_beta_subunit FrhB 14.0 1.0 0.0 5.148780360946799e-12 0.0001265897070942 6.329485612149018e-05 0.0001265897019454 0 0 0 0 K22163 0.0942857142857142 0.0 fpoH; F420H2 dehydrogenase subunit H [EC:1.5.98.3] 302.0 35.0 0.0 1.0 1.0 C 35.0 0.0 1.0 1.0 COG1005 NADH:ubiquinone_oxidoreductase_subunit_1_(chain_H) NuoH 35.0 1.0 0.0 0.949006241532122 0.984362144975608 0.966684193253865 0.035355903443486 0 0 1 1 K22164 0.0628571428571428 0.0 fpoI; F420H2 dehydrogenase subunit I [EC:1.5.98.3] 131.0 22.0 0.0 1.0 1.0 C 22.0 0.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 22.0 1.0 0.0 0.801063090496038 0.0988812116433845 0.4499721510697112 0.7021818788526535 0 0 1 1 K22165 0.0914285714285714 0.0 fpoJ; F420H2 dehydrogenase subunit J [EC:1.5.98.3] 53.0 41.0 0.0 1.0 1.0 C 41.0 0.0 1.0 1.0 COG0839 NADH:ubiquinone_oxidoreductase_subunit_6_(chain_J) NuoJ 41.0 1.0 0.0 0.0039890826613349 0.0091579180386319 0.0065735003499834 0.005168835377297 0 0 0 0 K22166 0.1371428571428571 0.0 fpoK; F420H2 dehydrogenase subunit K [EC:1.5.98.3] 92.0 49.0 0.0 1.0 1.0 C 49.0 0.0 1.0 1.0 COG0713 NADH:ubiquinone_oxidoreductase_subunit_11_or_4L_(chain_K) NuoK 49.0 1.0 0.0 0.952160215831185 0.511954506057937 0.7320573609445611 0.440205709773248 0 0 1 1 K22167 0.1 0.0 fpoL; F420H2 dehydrogenase subunit L [EC:1.5.98.3] 536.0 36.0 35.0 2.0 0.972972972972973 C 37.0 0.0 1.0 1.0 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 37.0 1.0 0.0 0.8893603254802 0.0253250145567633 0.4573426700184816 0.8640353109234368 0 0 1 1 K22168 0.12 0.0 fpoM; F420H2 dehydrogenase subunit M [EC:1.5.98.3] 414.0 43.0 0.0 1.0 1.0 C 43.0 0.0 1.0 1.0 COG1008 NADH:ubiquinone_oxidoreductase_subunit_4_(chain_M) NuoM 43.0 1.0 0.0 0.0098469499036649 0.0024760885759241 0.0061615192397945 0.0073708613277408 0 0 0 0 K22169 0.22 0.0 fpoN; F420H2 dehydrogenase subunit N [EC:1.5.98.3] 394.0 78.0 77.0 2.0 0.987341772151899 C 79.0 0.0 2.0 0.987341772151899 COG1007 NADH:ubiquinone_oxidoreductase_subunit_2_(chain_N) NuoN 79.0 1.0 0.0 0.848290040447375 0.977838087779953 0.913064064113664 0.1295480473325779 0 0 1 1 K22170 0.0371428571428571 0.0 fpoO; F420H2 dehydrogenase subunit O [EC:1.5.98.3] 109.0 13.0 0.0 1.0 1.0 C 13.0 0.0 1.0 1.0 arCOG04959 13.0 1.0 0.0 3.6479153710057e-05 0.0021087572550748 0.0010726182043924 0.0020722781013647 0 0 0 0 K22171 0.1142857142857142 0.0 fqoA; F420H2:quinone oxidoreductase subunit A [EC:1.1.98.4] 102.0 43.0 0.0 1.0 1.0 C 43.0 0.0 1.0 1.0 COG0838 NADH:ubiquinone_oxidoreductase_subunit_3_(chain_A) NuoA 43.0 1.0 0.0 0.0050347656135389 0.0283750299472517 0.0167048977803953 0.0233402643337128 0 0 0 0 K22172 0.0 0.0 fqoBC; F420H2:quinone oxidoreductase subunit B/C [EC:1.1.98.4] 70.0 0.0 1.0 1.0 C 0.0 0.0 3.0 0.457142857142857 COG0377 NADH:ubiquinone_oxidoreductase_20_kD_subunit_(chain_B)_or_related_Fe-S_oxidoreductase NuoB 0.0 0 0 0 0 K22173 0.1514285714285714 0.0 fqoD; F420H2:quinone oxidoreductase subunit D [EC:1.1.98.4] 327.0 66.0 0.0 1.0 1.0 C 66.0 0.0 2.0 0.833333333333333 COG0649 NADH:ubiquinone_oxidoreductase_49_kD_subunit_(chain_D) NuoD 66.0 1.0 0.0 0.0027175516497023 0.0083079833403831 0.0055127674950426 0.0055904316906808 0 0 0 0 K22174 0.1171428571428571 0.0 fqoF; F420H2:quinone oxidoreductase subunit F [EC:1.1.98.4] 191.0 56.0 0.0 1.0 1.0 C 56.0 0.0 3.0 0.857142857142857 COG1035 Coenzyme_F420-reducing_hydrogenase,_beta_subunit FrhB 56.0 1.0 0.0 0.666942946186013 0.619916782422062 0.6434298643040375 0.0470261637639509 0 0 0 1 K22175 0.1285714285714285 0.0 fqoH; F420H2:quinone oxidoreductase subunit H [EC:1.1.98.4] 298.0 49.0 0.0 1.0 1.0 C 49.0 0.0 1.0 1.0 COG1005 NADH:ubiquinone_oxidoreductase_subunit_1_(chain_H) NuoH 49.0 1.0 0.0 0.288405823975907 0.56539398590297 0.4268999049394385 0.2769881619270629 0 0 0 0 K22176 0.1285714285714285 0.0 fqoI; F420H2:quinone oxidoreductase subunit I [EC:1.1.98.4] 127.0 45.0 0.0 1.0 1.0 C 45.0 0.0 1.0 1.0 COG1143 Formate_hydrogenlyase_subunit_6/NADH:ubiquinone_oxidoreductase_23_kD_subunit_(chain_I) NuoI 45.0 1.0 0.0 0.0067754460473848 0.0074247434693289 0.0071000947583568 0.000649297421944 0 0 0 0 K22177 0.0428571428571428 0.0 fqoJ; F420H2:quinone oxidoreductase subunit J [EC:1.1.98.4] 133.0 15.0 0.0 1.0 1.0 C 15.0 0.0 1.0 1.0 COG0839 NADH:ubiquinone_oxidoreductase_subunit_6_(chain_J) NuoJ 15.0 1.0 0.0 4.33918839740257e-05 3.36193688844134e-12 2.1695943667981293e-05 4.339188061208881e-05 0 0 0 0 K22178 0.0571428571428571 0.0 fqoK; F420H2:quinone oxidoreductase subunit K [EC:1.1.98.4] 95.0 20.0 0.0 1.0 1.0 C 20.0 0.0 1.0 1.0 COG0713 NADH:ubiquinone_oxidoreductase_subunit_11_or_4L_(chain_K) NuoK 20.0 1.0 0.0 0.007797188261271 0.0139989984711517 0.0108980933662113 0.0062018102098807 0 0 0 0 K22179 0.06 0.0 fqoL; F420H2:quinone oxidoreductase subunit L [EC:1.1.98.4] 543.0 25.0 0.0 1.0 1.0 C 25.0 0.0 1.0 1.0 COG1009 Membrane_H+-translocase/NADH:ubiquinone_oxidoreductase_subunit_5_(chain_L)/Multisubunit_Na+/H+_antiporter,_MnhA_subunit NuoL 25.0 1.0 0.0 0.0018539355473063 0.0053441636152937 0.0035990495813 0.0034902280679874 0 0 0 0 K22180 0.0885714285714285 0.0 fqoM; F420H2:quinone oxidoreductase subunit M [EC:1.1.98.4] 417.0 21.0 8.0 2.0 0.617647058823529 C 34.0 0.0 2.0 0.970588235294118 COG0651 Formate_hydrogenlyase_subunit_3/Multisubunit_Na+/H+_antiporter,_MnhD_subunit HyfB 34.0 1.0 0.0 0.0743144605953189 0.361427599109469 0.2178710298523939 0.2871131385141501 0 0 0 0 K22181 0.0914285714285714 0.0 fqoN; F420H2:quinone oxidoreductase subunit N [EC:1.1.98.4] 346.0 33.0 0.0 1.0 1.0 C 33.0 0.0 1.0 1.0 COG1007 NADH:ubiquinone_oxidoreductase_subunit_2_(chain_N) NuoN 33.0 1.0 0.0 0.307137386206416 0.575567723416423 0.4413525548114195 0.268430337210007 0 0 0 0 K22185 0.0 0.0398860398860398 xylB; D-xylose 1-dehydrogenase [EC:1.1.1.175] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 248.0 19.0 0.0 1.0 1.0 IQ 0.0 19.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 19.0 0.0 1.0 0.0033048551039398 0.0091774328611356 0.0062411439825377 0.0058725777571957 0 0 0 0 K22186 0.0 0.0712250712250712 xylD; xylonate dehydratase [EC:4.2.1.82] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 546.0 32.0 31.0 2.0 0.96969696969697 EG 0.0 33.0 1.0 1.0 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 33.0 0.0 1.0 0.0362012991527864 0.0718595047274627 0.0540304019401245 0.0356582055746763 0 0 0 0 K22187 0.0914285714285714 0.1794871794871795 xylA; alpha-ketoglutaric semialdehyde dehydrogenase [EC:1.2.1.-] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 406.0 109.0 0.0 1.0 1.0 C 32.0 77.0 2.0 0.990825688073395 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 109.0 0.2935779816513761 0.7064220183486238 0.185885211635384 0.957870400763096 0.57187780619924 0.7719851891277121 0 0 0 0 K22199 0.1 0.0 ppm; phosphopentomutase [EC:5.4.2.7] path:map00030,path:map00230,path:map01100 Pentose phosphate pathway,Purine metabolism,Metabolic pathways 379.0 39.0 0.0 1.0 1.0 G 39.0 0.0 1.0 1.0 COG1109 Phosphomannomutase ManB 39.0 1.0 0.0 0.935424227283709 0.992840048988063 0.964132138135886 0.057415821704354 0 0 1 1 K22205 0.4285714285714285 0.2678062678062678 E3.13.2.3; S-adenosyl-L-methionine hydrolase (adenosine-forming) [EC:3.13.2.3] 130.0 247.0 243.0 3.0 0.98015873015873 S 153.0 99.0 1.0 1.0 COG1912 Stereoselective_(R,S)-S-adenosylmethionine_hydrolase_(adenosine-forming) 252.0 0.6071428571428571 0.3928571428571428 0.153055333443043 0.857132188096333 0.5050937607696879 0.70407685465329 0 0 0 0 K22206 0.3485714285714286 0.0 thiR; XRE family transcriptional regulator, thiamine biosynthesis regulator 140.0 121.0 94.0 3.0 0.796052631578947 H 152.0 0.0 2.0 0.822368421052632 COG1992 Predicted_transcriptional_regulator_fused_phosphomethylpyrimidine_kinase_(thiamin_biosynthesis) 152.0 1.0 0.0 0.0018479063490719 0.789654751056729 0.3957513287029005 0.787806844707657 0 0 0 0 K22209 0.0 0.0227920227920227 tarD; D(-)-tartrate dehydratase [EC:4.2.1.81] 168.0 10.0 0.0 1.0 1.0 M 0.0 10.0 1.0 1.0 COG4948 L-alanine-DL-glutamate_epimerase_or_related_enzyme_of_enolase_superfamily RspA 10.0 0.0 1.0 0.0112148721521408 0.0252902978106856 0.0182525849814132 0.0140754256585447 0 0 0 0 K22210 0.0057142857142857 0.0085470085470085 DGLUCY; D-glutamate cyclase [EC:4.2.1.48] path:map00470,path:map01100 D-Amino acid metabolism,Metabolic pathways 270.0 5.0 0.0 1.0 1.0 S 2.0 3.0 1.0 1.0 2DB6N 5.0 0.4 0.6 0.0765031186606058 0.165648386557537 0.1210757526090714 0.0891452678969312 0 0 0 0 K22212 0.0 0.0199430199430199 mleA, mleS; malolactic enzyme [EC:4.1.1.101] path:map00620,path:map01100,path:map01120 Pyruvate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 526.0 9.0 0.0 1.0 1.0 C 0.0 9.0 1.0 1.0 COG0281 Malic_enzyme SfcA 9.0 0.0 1.0 0.0373383627035523 0.0570501604513249 0.0471942615774386 0.0197117977477725 0 0 0 0 K22213 0.0285714285714285 0.0313390313390313 PATG; 6-methylsalicylate decarboxylase [EC:4.1.1.52] 159.0 22.0 21.0 2.0 0.956521739130435 S 12.0 11.0 1.0 1.0 COG2159 5-carboxyvanillate_decarboxylase_LigW_(lignin_degradation),_amidohydro_domain LigW 23.0 0.5217391304347826 0.4782608695652174 0.243666894720058 0.337042350005782 0.29035462236292 0.0933754552857239 0 0 0 0 K22214 0.0028571428571428 0.017094017094017 scpC; propionyl-CoA:succinyl-CoA transferase [EC:2.8.3.27] path:map00640,path:map01100 Propanoate metabolism,Metabolic pathways 478.0 8.0 0.0 1.0 1.0 C 1.0 7.0 1.0 1.0 COG0427 Propionyl_CoA:succinate_CoA_transferase ACH1 8.0 0.125 0.875 0.0684687683958653 0.107965886366721 0.0882173273812931 0.0394971179708557 0 0 0 0 K22215 0.0 0.0142450142450142 galD; galactose dehydrogenase [EC:1.1.1.48 1.1.1.120] path:map00052,path:map01100 Galactose metabolism,Metabolic pathways 249.0 5.0 0.0 1.0 1.0 IQ 0.0 5.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 5.0 0.0 1.0 0.0059196150964075 0.0257122418174618 0.0158159284569346 0.0197926267210543 0 0 0 0 K22216 0.0 0.0028490028490028 ilvD1; dehydratase ilvD1 571.0 1.0 0.0 1.0 1.0 EG 0.0 1.0 1.0 1.0 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 1.0 0.0 1.0 0 0 0 0 K22217 0.0 0.0085470085470085 K22217; sugar lactone lactonase 221.0 2.0 1.0 2.0 0.666666666666667 G 0.0 3.0 2.0 0.666666666666667 COG3386 Sugar_lactone_lactonase_YvrE YvrE 3.0 0.0 1.0 0 0 0 0 K22219 0.0 0.0028490028490028 dszC; dibenzothiophene monooxygenase [EC:1.14.14.21] 366.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 1.0 0.0 1.0 0 0 0 0 K22221 0.1028571428571428 0.0028490028490028 K22221; HEAT repeat-containing taxis protein 352.0 29.0 18.0 2.0 0.725 C 39.0 1.0 2.0 0.725 COG1413 HEAT_repeat HEAT 40.0 0.975 0.025 0.138655136174793 0.360335489218877 0.249495312696835 0.2216803530440839 0 0 0 0 K22222 0.2342857142857143 0.0113960113960113 cetZ; tubulin-like protein CetZ 264.0 202.0 0.0 1.0 1.0 D 195.0 7.0 2.0 0.99009900990099 COG0206 Cell_division_GTPase_FtsZ FtsZ 202.0 0.9653465346534652 0.0346534653465346 0.97028358684556 0.8236127220946 0.89694815447008 0.14667086475096 1 1 1 1 K22223 0.4914285714285714 0.0 pgp; phosphoglycolate phosphatase [EC:3.1.3.18] path:map00630,path:map01100,path:map01110 Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 152.0 154.0 140.0 3.0 0.88 G 175.0 0.0 1.0 1.0 COG0561 Hydroxymethylpyrimidine_pyrophosphatase_and_other_HAD_family_phosphatases Cof 175.0 1.0 0.0 0.163072593929725 0.916135706726129 0.539604150327927 0.753063112796404 0 0 0 0 K22224 0.5914285714285714 0.1452991452991453 acdB; acetate---CoA ligase (ADP-forming) subunit beta [EC:6.2.1.13] path:map00010,path:map00620,path:map00640,path:map01100,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Propanoate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 123.0 464.0 460.0 4.0 0.980972515856237 C 316.0 100.0 4.0 0.691331923890063 COG1042 Acyl-CoA_synthetase_(NDP_forming) PatZN 416.0 0.7596153846153846 0.2403846153846154 0.685744375604123 0.953877666508273 0.819811021056198 0.2681332909041499 0 1 0 1 K22225 0.0628571428571428 0.0 ahbAB; siroheme decarboxylase [EC:4.1.1.111] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 136.0 39.0 0.0 1.0 1.0 K 39.0 0.0 1.0 1.0 COG1522 DNA-binding_transcriptional_regulator,_Lrp_family Lrp 39.0 1.0 0.0 0.12762926240449 0.690350999147515 0.4089901307760025 0.562721736743025 0 0 0 0 K22226 0.1857142857142857 0.094017094017094 ahbC; Fe-coproporphyrin III synthase path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 239.0 60.0 19.0 3.0 0.540540540540541 S 74.0 37.0 1.0 1.0 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 111.0 0.6666666666666666 0.3333333333333333 0.206642587626 0.0578370262711661 0.132239806948583 0.1488055613548339 0 0 0 0 K22227 0.2571428571428571 0.1566951566951566 ahbD; AdoMet-dependent heme synthase [EC:1.3.98.6] path:map00860,path:map01100,path:map01110,path:map01240 Porphyrin metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Biosynthesis of cofactors 133.0 88.0 6.0 4.0 0.45360824742268 S 122.0 72.0 1.0 1.0 COG0535 Radical_SAM_superfamily_maturase,_SkfB/NifB/PqqE_family SkfB 194.0 0.6288659793814433 0.3711340206185567 0.804313025236071 0.919432260215049 0.86187264272556 0.115119234978978 1 1 1 1 K22228 0.0171428571428571 0.0 secG, sec61beta; preprotein translocase subunit SecG 215.0 6.0 0.0 1.0 1.0 arCOG05740 6.0 1.0 0.0 0 0 0 0 K22229 0.0 0.0142450142450142 K22229; 2-ketogluconate reductase [EC:1.1.1.215] path:map00030,path:map01100,path:map01120 Pentose phosphate pathway,Metabolic pathways,Microbial metabolism in diverse environments 305.0 6.0 0.0 1.0 1.0 CH 0.0 6.0 1.0 1.0 COG1052 Lactate_dehydrogenase_or_related_2-hydroxyacid_dehydrogenase LdhA 6.0 0.0 1.0 0.0134352000715077 0.015758805091922 0.0145970025817148 0.0023236050204142 0 0 0 0 K22230 0.0057142857142857 0.0427350427350427 iolU; scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.-] path:map00562,path:map01100,path:map01120 Inositol phosphate metabolism,Metabolic pathways,Microbial metabolism in diverse environments 271.0 20.0 0.0 1.0 1.0 S 2.0 18.0 1.0 1.0 COG0673 Predicted_dehydrogenase MviM 20.0 0.1 0.9 0.0243255861275806 0.104918930395122 0.0646222582613513 0.0805933442675414 0 0 0 0 K22231 0.0085714285714285 0.0056980056980056 iolM; scyllo-inosose 3-dehydrogenase [EC:1.1.1.-] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 392.0 3.0 1.0 2.0 0.6 C 3.0 2.0 1.0 1.0 COG1063 Threonine_dehydrogenase_or_related_Zn-dependent_dehydrogenase Tdh 5.0 0.6 0.4 0.457016866852058 0.219143162928569 0.3380800148903135 0.237873703923489 0 0 0 0 K22232 0.0142857142857142 0.0113960113960113 iolN; 3-dehydro-scyllo-inosose hydrolase [EC:3.7.1.-] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 304.0 7.0 5.0 2.0 0.777777777777778 S 5.0 4.0 1.0 1.0 COG1402 Creatinine_amidohydrolase/Fe(II)-dependent_FAPy_formamide_hydrolase_(riboflavin_and_F420_biosynthesis) ArfB 9.0 0.5555555555555556 0.4444444444444444 0.0156869169458668 0.0568257482245791 0.0362563325852229 0.0411388312787123 0 0 0 0 K22233 0.02 0.0056980056980056 iolO; 5-keto-L-gluconate epimerase [EC:5.1.-.-] path:map00562,path:map01100 Inositol phosphate metabolism,Metabolic pathways 242.0 9.0 0.0 1.0 1.0 G 7.0 2.0 1.0 1.0 COG1082 Sugar_phosphate_isomerase/epimerase YcjR 9.0 0.7777777777777778 0.2222222222222222 0.93316136823532 0.890158600953431 0.9116599845943756 0.043002767281889 0 0 1 1 K22245 0.0 0.0028490028490028 INUA; inulinase [EC:3.2.1.7] 680.0 1.0 0.0 1.0 1.0 G 0.0 1.0 1.0 1.0 COG1621 Sucrose-6-phosphate_hydrolase_SacC,_GH32_family SacC 1.0 0.0 1.0 0 0 0 0 K22249 0.0 0.0113960113960113 phaZ; poly(3-hydroxyoctanoate) depolymerase [EC:3.1.1.76] 189.0 4.0 0.0 1.0 1.0 Q 0.0 4.0 1.0 1.0 COG0412 Dienelactone_hydrolase DLH 4.0 0.0 1.0 0.0148528392262535 0.0496646755008157 0.0322587573635346 0.0348118362745622 0 0 0 0 K22250 0.0 0.017094017094017 phaZ; poly(3-hydroxyoctanoate) depolymerase [EC:3.1.1.76] 237.0 4.0 1.0 2.0 0.571428571428571 S 0.0 7.0 3.0 0.428571428571429 COG2267 Lysophospholipase,_alpha-beta_hydrolase_superfamily PldB 7.0 0.0 1.0 0.0086062661634813 0.0142488854357555 0.0114275757996184 0.0056426192722742 0 0 0 0 K22251 0.0 0.0028490028490028 golD; glycerol dehydrogenase [EC:1.1.1.6] path:map00561,path:map01100 Glycerolipid metabolism,Metabolic pathways 255.0 1.0 0.0 1.0 1.0 IQ 0.0 1.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 1.0 0.0 1.0 0 0 0 0 K22252 0.0028571428571428 0.0142450142450142 tld; GDP-6-deoxy-D-talose 4-dehydrogenase [EC:1.1.1.135] path:map00051,path:map00520,path:map00541,path:map01100,path:map01250 Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,O-Antigen nucleotide sugar biosynthesis,Metabolic pathways,Biosynthesis of nucleotide sugars 290.0 5.0 4.0 2.0 0.833333333333333 M 1.0 5.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 6.0 0.1666666666666666 0.8333333333333334 0.10253931580486 0.208418586342766 0.155478951073813 0.105879270537906 0 0 0 0 K22253 0.0 0.0056980056980056 mta; glucan 1,4-alpha-maltotetraohydrolase [EC:3.2.1.60] 413.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG0366 Glycosidase/amylase_(phosphorylase) AmyA 2.0 0.0 1.0 0 0 0 0 K22268 0.0 0.0113960113960113 xylA; xylan 1,4-beta-xylosidase [EC:3.2.1.37] path:map00520,path:map01100 Amino sugar and nucleotide sugar metabolism,Metabolic pathways 646.0 4.0 0.0 1.0 1.0 NU 0.0 4.0 1.0 1.0 COG3170 Type_IV_pilus_assembly_protein_FimV FimV 4.0 0.0 1.0 0.165765393328402 0.2576759501502 0.211720671739301 0.091910556821798 0 0 0 0 K22269 0.0 0.0028490028490028 rosA; 8-amino-8-demethylriboflavin N,N-dimethyltransferase [EC:2.1.1.343] path:map00998,path:map01100,path:map01110 Biosynthesis of various antibiotics; Including: Kanosamine biosynthesis, Aurachin biosynthesis, Bacilysin biosynthesis, Puromycin biosynthesis, Dapdiamides biosynthesis, Fosfomycin biosynthesis, Cremeomycin biosynthesis, Pentalenolactone biosynthesis, Terpentecin biosynthesis, Roseoflavin biosynthesis, Cycloserine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 322.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 COG0500 SAM-dependent_methyltransferase SmtA 1.0 0.0 1.0 0 0 0 0 K22270 0.0 0.0341880341880341 nagX; 3-hydroxybenzoate 6-monooxygenase [EC:1.14.13.24] path:map00362,path:map01120 Benzoate degradation,Microbial metabolism in diverse environments 373.0 11.0 10.0 2.0 0.916666666666667 CH 0.0 12.0 1.0 1.0 COG0654 2-polyprenyl-6-methoxyphenol_hydroxylase_and_related_FAD-dependent_oxidoreductases UbiH 12.0 0.0 1.0 0.0334836032994049 0.0735735139180265 0.0535285586087156 0.0400899106186216 0 0 0 0 K22278 0.1914285714285714 0.4074074074074074 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104] 16.0 271.0 243.0 9.0 0.833846153846154 G 88.0 237.0 13.0 0.889230769230769 COG0726 Peptidoglycan/xylan/chitin_deacetylase,_PgdA/NodB/CDA1_family CDA1 325.0 0.2707692307692307 0.7292307692307692 0.118607033125058 0.20753213945879 0.163069586291924 0.088925106333732 0 0 0 0 K22282 0.0 0.0028490028490028 FAXDC2; fatty acid hydroxylase domain-containing protein 2 286.0 1.0 0.0 1.0 1.0 I 0.0 1.0 1.0 1.0 COG3000 Sterol_desaturase/sphingolipid_hydroxylase,_fatty_acid_hydroxylase_superfamily ERG3 1.0 0.0 1.0 0 0 0 0 K22292 0.0142857142857142 0.0598290598290598 mupP; N-acetyl-D-muramate 6-phosphate phosphatase [EC:3.1.3.105] path:map00520,path:map01100,path:map01250 Amino sugar and nucleotide sugar metabolism,Metabolic pathways,Biosynthesis of nucleotide sugars 164.0 21.0 14.0 2.0 0.75 S 6.0 22.0 1.0 1.0 COG0546 Phosphoglycolate_phosphatase,_HAD_superfamily Gph 28.0 0.2142857142857142 0.7857142857142857 0.0047095108737688 0.0163343826542706 0.0105219467640197 0.0116248717805018 0 0 0 0 K22293 0.0 0.0427350427350427 rspR; GntR family transcriptional regulator, rspAB operon transcriptional repressor 184.0 22.0 0.0 1.0 1.0 K 0.0 22.0 1.0 1.0 COG1802 DNA-binding_transcriptional_regulator,_GntR_family GntR 22.0 0.0 1.0 0.0096399527152682 0.0158973209807745 0.0127686368480213 0.0062573682655062 0 0 0 0 K22295 0.0 0.0142450142450142 K22295; TetR/AcrR family transcriptional regulator, repressor for neighboring sulfatase 185.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1309 DNA-binding_protein,_AcrR_family,_includes_nucleoid_occlusion_protein_SlmA AcrR 6.0 0.0 1.0 0.0341752244309475 0.0793488898926514 0.0567620571617994 0.0451736654617039 0 0 0 0 K22296 0.0 0.0284900284900284 nicR; MarR family transcriptional regulator, lower aerobic nicotinate degradation pathway regulator 135.0 12.0 0.0 1.0 1.0 K 0.0 12.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 12.0 0.0 1.0 0.0065094135893669 0.0083319313393433 0.0074206724643551 0.0018225177499764 0 0 0 0 K22297 0.0 0.0826210826210826 furA; Fur family transcriptional regulator, stress-responsive regulator 128.0 34.0 33.0 2.0 0.971428571428571 P 0.0 35.0 1.0 1.0 COG0735 Fe2+_or_Zn2+_uptake_regulation_protein_Fur/Zur Fur 35.0 0.0 1.0 0.0164396423054859 0.0706862490239985 0.0435629456647422 0.0542466067185126 0 0 0 0 K22298 0.0057142857142857 0.0455840455840455 smtB; ArsR family transcriptional regulator, zinc-responsive transcriptional repressor 90.0 22.0 0.0 1.0 1.0 K 2.0 20.0 1.0 1.0 COG0640 DNA-binding_transcriptional_regulator,_ArsR_family ArsR 22.0 0.0909090909090909 0.9090909090909092 0.0100919427971579 0.0303802791643539 0.0202361109807559 0.020288336367196 0 0 0 0 K22299 0.0 0.0227920227920227 rghR; HTH-type transcriptional regulator, competence development regulator 59.0 6.0 4.0 2.0 0.75 K 0.0 8.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 8.0 0.0 1.0 0.0258108725849255 0.058103917097059 0.0419573948409922 0.0322930445121334 0 0 0 0 K22300 0.0 0.0199430199430199 dicA; HTH-type transcriptional regulator, cell division transcriptional repressor 78.0 7.0 0.0 1.0 1.0 K 0.0 7.0 1.0 1.0 COG1396 Transcriptional_regulator,_contains_XRE-family_HTH_domain HipB 7.0 0.0 1.0 0.0640086795095671 0.136447742097839 0.100228210803703 0.0724390625882719 0 0 0 0 K22301 0.0 0.0085470085470085 opcR; HTH-type transcriptional regulator, osmoprotectant uptake regulator 162.0 3.0 0.0 1.0 1.0 K 0.0 3.0 1.0 1.0 COG1510 DNA-binding_transcriptional_regulator_GbsR,_MarR_family GbsR 3.0 0.0 1.0 0 0 0 0 K22302 0.0 0.0056980056980056 dicC; transcriptional repressor of cell division inhibition gene dicB 57.0 1.0 0.0 2.0 0.5 K 0.0 2.0 2.0 0.5 2AV39 2.0 0.0 1.0 0 0 0 0 K22303 0.0 0.074074074074074 atsK; alkyl sulfatase [EC:1.14.11.77] 214.0 39.0 0.0 1.0 1.0 Q 0.0 39.0 1.0 1.0 COG2175 Taurine_dioxygenase,_alpha-ketoglutarate-dependent TauD 39.0 0.0 1.0 0.0007512132426781 0.0037413457974866 0.0022462795200823 0.0029901325548085 0 0 0 0 K22304 0.0 0.0028490028490028 dicB; cell division inhibition protein DicB 62.0 1.0 0.0 1.0 1.0 D 0.0 1.0 1.0 1.0 2AV4R 1.0 0.0 1.0 0 0 0 0 K22305 0.0657142857142857 0.1908831908831909 psp; phosphoserine phosphatase [EC:3.1.3.3] path:map00260,path:map00680,path:map01100,path:map01110,path:map01120,path:map01200,path:map01230 Glycine, serine and threonine metabolism,Methane metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments,Carbon metabolism,Biosynthesis of amino acids 78.0 110.0 0.0 1.0 1.0 G 28.0 82.0 1.0 1.0 COG0406 Broad_specificity_phosphatase_PhoE PhoE 110.0 0.2545454545454545 0.7454545454545455 0.812517677610816 0.368265340927326 0.590391509269071 0.4442523366834899 1 1 1 1 K22306 0.0 0.0797720797720797 gpgP; glucosyl-3-phosphoglycerate phosphatase [EC:3.1.3.85] 159.0 33.0 0.0 1.0 1.0 G 0.0 33.0 1.0 1.0 COG0406 Broad_specificity_phosphatase_PhoE PhoE 33.0 0.0 1.0 0.0056540536881272 0.0121327984130848 0.008893426050606 0.0064787447249575 0 0 0 0 K22307 0.0 0.0056980056980056 E3.2.1.204; 1,3-alpha-isomaltosidase [EC:3.2.1.204] 727.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG1501 Alpha-glucosidase/xylosidase,_GH31_family YicI 2.0 0.0 1.0 0 0 0 0 K22308 0.0 0.0056980056980056 E3.2.1.205; isomaltose glucohydrolase [EC:3.2.1.205] 187.0 2.0 0.0 1.0 1.0 G 0.0 2.0 1.0 1.0 COG3387 Glucoamylase_(glucan-1,4-alpha-glucosidase),_GH15_family SGA1 2.0 0.0 1.0 0 0 0 0 K22309 0.0 0.0113960113960113 olsG; ornithine lipid N-methyltransferase [EC:2.1.1.344] 180.0 4.0 0.0 1.0 1.0 I 0.0 4.0 1.0 1.0 COG3963 Phosphatidylethanolamine_N-methyltransferase 4.0 0.0 1.0 0.0136658388901973 0.0727252134755237 0.0431955261828605 0.0590593745853264 0 0 0 0 K22310 0.0 0.0199430199430199 olsB; L-ornithine Nalpha-acyltransferase [EC:2.3.2.30] 276.0 7.0 0.0 1.0 1.0 S 0.0 7.0 1.0 1.0 COG3176 Putative_hemolysin 7.0 0.0 1.0 1.00699901113737e-06 2.77816906144096e-12 5.035008946532157e-07 1.0069962329683087e-06 0 0 0 0 K22311 0.0028571428571428 0.1025641025641025 ptfP1; phosphatidylinositol dimannoside acyltransferase [EC:2.3.1.265] path:map00571,path:map01100 Lipoarabinomannan (LAM) biosynthesis,Metabolic pathways 190.0 40.0 0.0 1.0 1.0 M 1.0 39.0 1.0 1.0 COG1560 Palmitoleoyl-ACP:_Kdo2-lipid-IV_acyltransferase_(lipid_A_biosynthesis) LpxP 40.0 0.025 0.975 0.012507506250213 0.927020063576844 0.4697637849135285 0.914512557326631 0 0 0 0 K22313 0.0 0.0028490028490028 E3.1.7.12; (+)-kolavelool synthase [EC:3.1.7.12] 289.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 28XHJ 1.0 0.0 1.0 0 0 0 0 K22316 0.0228571428571428 0.0883190883190883 rhnA-cobC; ribonuclease H / adenosylcobalamin/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73] path:map00860,path:map01100,path:map01240,path:map03030 Porphyrin metabolism,Metabolic pathways,Biosynthesis of cofactors,DNA replication 109.0 25.0 12.0 4.0 0.625 GL 8.0 32.0 1.0 1.0 COG0328 Ribonuclease_HI RnhA 40.0 0.2 0.8 0.294550053674043 0.983391711322924 0.6389708824984836 0.688841657648881 0 0 0 0 K22317 0.0057142857142857 0.0683760683760683 oleA; acyl-CoA:acyl-CoA alkyltransferase [EC:2.3.3.20] 285.0 26.0 0.0 1.0 1.0 I 2.0 24.0 1.0 1.0 COG0332 3-oxoacyl-[acyl-carrier-protein]_synthase_III FabH 26.0 0.0769230769230769 0.9230769230769232 0.0081116161364583 0.0463009379340124 0.0272062770352353 0.0381893217975541 0 0 0 0 K22318 0.0171428571428571 0.0626780626780626 oleB; cis-3-alkyl-4-acyloxetan-2-one decarboxylase [EC:4.1.1.114] 177.0 15.0 4.0 3.0 0.483870967741936 S 7.0 24.0 3.0 0.516129032258065 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 31.0 0.2258064516129032 0.7741935483870968 0.0059261651718938 0.0107824344289645 0.0083542998004291 0.0048562692570707 0 0 0 0 K22319 0.0 0.0826210826210826 oleC; olefin beta-lactone synthetase [EC:6.1.3.1] 317.0 33.0 31.0 2.0 0.942857142857143 IQ 0.0 34.0 2.0 0.942857142857143 COG0318 O-succinylbenzoic_acid-CoA_ligase_MenE_or_related_acyl-CoA_synthetase_(AMP-forming) MenE/FadK 34.0 0.0 1.0 0.0069909268565459 0.150056352678357 0.0785236397674514 0.1430654258218111 0 0 0 0 K22320 0.0028571428571428 0.0911680911680911 oleD; 2-alkyl-3-oxoalkanoate reductase [EC:1.1.1.412] 254.0 30.0 22.0 2.0 0.789473684210526 M 1.0 37.0 1.0 1.0 COG0451 Nucleoside-diphosphate-sugar_epimerase WcaG 38.0 0.0263157894736842 0.9736842105263158 0.0186481657885793 0.0210350147436217 0.0198415902661005 0.0023868489550423 0 0 0 0 K22322 0.0028571428571428 0.0227920227920227 barS1; A-factor type gamma-butyrolactone 1'-reductase (1S-forming) [EC:1.1.1.413] 244.0 10.0 0.0 1.0 1.0 IQ 1.0 9.0 1.0 1.0 COG1028 NAD(P)-dependent_dehydrogenase,_short-chain_alcohol_dehydrogenase_family FabG 10.0 0.1 0.9 0.0067602703765176 0.0211008596949501 0.0139305650357338 0.0143405893184325 0 0 0 0 K22325 0.0 0.0028490028490028 cndA; chloroacetanilide N-alkylformylase [EC:1.14.15.23] 356.0 1.0 0.0 1.0 1.0 P 0.0 1.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 1.0 0.0 1.0 0 0 0 0 K22330 0.0057142857142857 0.0028490028490028 tyrDC; tyrosine decarboxylase [EC:4.1.1.25] path:map00350,path:map01100 Tyrosine metabolism,Metabolic pathways 486.0 3.0 0.0 1.0 1.0 E 2.0 1.0 1.0 1.0 COG0076 Glutamate_or_tyrosine_decarboxylase_or_a_related_PLP-dependent_protein GadA 3.0 0.6666666666666666 0.3333333333333333 0 0 0 0 K22333 0.0028571428571428 0.0028490028490028 blaOXA-493; beta-lactamase class D OXA-493 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 268.0 2.0 0.0 1.0 1.0 V 1.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.5 0.5 0 0 0 0 K22334 0.0028571428571428 0.0028490028490028 blaOXA-464; beta-lactamase class D OXA-464 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 268.0 2.0 0.0 1.0 1.0 V 1.0 1.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.5 0.5 0 0 0 0 K22335 0.0 0.0028490028490028 blaOXA-114; beta-lactamase class D OXA-114 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 69.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K22336 0.0 0.0341880341880341 bfrB; bacterioferritin B [EC:1.16.3.1] path:map00860 Porphyrin metabolism 163.0 12.0 0.0 1.0 1.0 P 0.0 12.0 1.0 1.0 COG1528 Ferritin FtnA 12.0 0.0 1.0 0.0360104270001517 0.0892994688201335 0.0626549479101426 0.0532890418199817 0 0 0 0 K22338 0.0 0.0085470085470085 hylA; formate dehydrogenase (NAD+, ferredoxin) subunit A [EC:1.17.1.11] 308.0 3.0 0.0 1.0 1.0 C 0.0 3.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 3.0 0.0 1.0 0 0 0 0 K22339 0.0057142857142857 0.0427350427350427 hylB; formate dehydrogenase (NAD+, ferredoxin) subunit B [EC:1.17.1.11] 567.0 22.0 0.0 1.0 1.0 C 2.0 20.0 1.0 1.0 COG1894 NADH:ubiquinone_oxidoreductase,_NADH-binding_51_kD_subunit_(chain_F) NuoF 22.0 0.0909090909090909 0.9090909090909092 0.233036762479681 0.235749523240772 0.2343931428602265 0.002712760761091 0 0 0 0 K22340 0.0 0.037037037037037 hylC; formate dehydrogenase (NAD+, ferredoxin) subunit C [EC:1.17.1.11] 155.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 COG1905 NADH:ubiquinone_oxidoreductase_24_kD_subunit_(chain_E) NuoE 13.0 0.0 1.0 0.0445407647938649 0.0609194879149496 0.0527301263544072 0.0163787231210846 0 0 0 0 K22341 0.0 0.0 fdhF2; formate dehydrogenase (NAD+, ferredoxin) subunit [EC:1.17.1.11] 14.0 0.0 1.0 1.0 C 0.0 0.0 1.0 1.0 COG3383 Predicted_molibdopterin-dependent_oxidoreductase_YjgC YjgC 0.0 0 0 0 0 K22342 0.0 0.0826210826210826 dmmA; dimethylamine monooxygenase subunit A [EC:1.14.13.238] 187.0 33.0 0.0 1.0 1.0 S 0.0 33.0 2.0 0.96969696969697 2DB9X 33.0 0.0 1.0 0.0255509131835184 0.0948682397932869 0.0602095764884026 0.0693173266097685 0 0 0 0 K22343 0.0 0.037037037037037 dmmB; dimethylamine monooxygenase subunit B [EC:1.14.13.238] 300.0 13.0 0.0 1.0 1.0 C 0.0 13.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 13.0 0.0 1.0 0.0467679356824793 0.0938732307019392 0.0703205831922092 0.0471052950194599 0 0 0 0 K22344 0.0 0.0313390313390313 dmmC; dimethylamine monooxygenase subunit C [EC:1.14.13.238] 149.0 0.0 12.0 3.0 0.583333333333333 28IUB 12.0 0.0 1.0 0 0 0 0 K22345 0.0085714285714285 0.017094017094017 E4.3.1.9; glucosaminate ammonia-lyase [EC:4.3.1.9] path:map00030,path:map01100 Pentose phosphate pathway,Metabolic pathways 303.0 8.0 6.0 2.0 0.8 O 3.0 7.0 1.0 1.0 COG0492 Thioredoxin_reductase TrxB 10.0 0.3 0.7 0.0481961681468261 0.695854059299143 0.3720251137229846 0.6476578911523169 0 0 0 0 K22347 0.0 0.0113960113960113 nox; 4,4'-dithiodibutanoate disulfide reductase [EC:1.8.1.20] 391.0 4.0 0.0 1.0 1.0 C 0.0 4.0 1.0 1.0 COG1902 2,4-dienoyl-CoA_reductase_or_related_NADH-dependent_reductase,_Old_Yellow_Enzyme_(OYE)_family FadH 4.0 0.0 1.0 4.66712155577352e-05 0.001359694923246 0.0007031830694018 0.0013130237076882 0 0 0 0 K22348 0.0057142857142857 0.0854700854700854 moxA; manganese oxidase [EC:1.16.3.3] 199.0 48.0 0.0 1.0 1.0 Q 2.0 46.0 2.0 0.958333333333333 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 48.0 0.0416666666666666 0.9583333333333334 0.0012313684367318 0.0058017335003137 0.0035165509685227 0.0045703650635819 0 0 0 0 K22349 0.0142857142857142 0.0284900284900284 mnxG; manganese oxidase [EC:1.16.3.3] 59.0 22.0 19.0 2.0 0.88 Q 5.0 17.0 3.0 0.88 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 22.0 0.2272727272727272 0.7727272727272727 0.0021031189500878 0.0115951677257499 0.0068491433379188 0.0094920487756621 0 0 0 0 K22350 0.0028571428571428 0.0227920227920227 mcoA; manganese oxidase [EC:1.16.3.3] 202.0 4.0 1.0 4.0 0.4 G 1.0 9.0 5.0 0.3 COG2132 Multicopper_oxidase_with_three_cupredoxin_domains_(includes_cell_division_protein_FtsP_and_spore_coat_protein_CotA) SufI 10.0 0.1 0.9 0.0724173980669533 0.148954066320641 0.1106857321937971 0.0765366682536877 0 0 0 0 K22351 0.0 0.0056980056980056 blaOXA-209; beta-lactamase class D OXA-209 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 278.0 2.0 0.0 1.0 1.0 V 0.0 2.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 2.0 0.0 1.0 0 0 0 0 K22352 0.0 0.0 blaOXA-29; beta-lactamase class D OXA-29 [EC:3.5.2.6] path:map01501 beta-Lactam resistance 3.0 0.0 1.0 1.0 V 0.0 0.0 1.0 1.0 COG2602 Beta-lactamase_class_D YbxI 0.0 0 0 0 0 K22353 0.0 0.0284900284900284 etnC; alkene monooxygenase alpha subunit [EC:1.14.13.69] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 77.0 9.0 7.0 2.0 0.818181818181818 T 0.0 11.0 1.0 1.0 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 11.0 0.0 1.0 0.0040301010782057 0.0164074291276515 0.0102187651029286 0.0123773280494458 0 0 0 0 K22357 0.0 0.0313390313390313 amoA; alkene monooxygenase alpha subunit [EC:1.14.13.69] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 73.0 10.0 9.0 2.0 0.909090909090909 T 0.0 11.0 1.0 1.0 COG3350 Heavy_metal-bindng_TRASH/YHS_domain,_predicted_Cu/Ag_metallochaperone YHS 11.0 0.0 1.0 0.0081749182564492 0.217154475307708 0.1126646967820786 0.2089795570512588 0 0 0 0 K22358 0.0 0.0028490028490028 amoE; alkene monooxygenase beta subunit [EC:1.14.13.69] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 341.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 2DB89 1.0 0.0 1.0 0 0 0 0 K22359 0.0 0.0028490028490028 amoB; alkene monooxygenase gamma subunit [EC:1.14.13.69] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 88.0 1.0 0.0 1.0 1.0 Q 0.0 1.0 1.0 1.0 2BXCC 1.0 0.0 1.0 0 0 0 0 K22360 0.0028571428571428 0.0227920227920227 amoC; alkene monooxygenase ferredoxin subunit path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 97.0 9.0 0.0 1.0 1.0 P 1.0 8.0 1.0 1.0 COG2146 Ferredoxin_subunit_of_nitrite_reductase_or_a_ring-hydroxylating_dioxygenase NirD 9.0 0.1111111111111111 0.8888888888888888 0.0682828851427393 0.155752922525496 0.1120179038341176 0.0874700373827567 0 0 0 0 K22361 0.0 0.0028490028490028 amoD; alkene monooxygenase effector subunit path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 101.0 1.0 0.0 1.0 1.0 S 0.0 1.0 1.0 1.0 COG3445 Autonomous_glycyl_radical_cofactor_GrcA GrcA 1.0 0.0 1.0 0 0 0 0 K22362 0.0 0.0028490028490028 amoF; alkene monooxygenase ferredoxin reductase component [EC:1.18.1.3] path:map00625,path:map01100,path:map01120 Chloroalkane and chloroalkene degradation,Metabolic pathways,Microbial metabolism in diverse environments 348.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG0543 NAD(P)H-flavin_reductase Mcr1 1.0 0.0 1.0 0 0 0 0 K22363 0.0 0.0142450142450142 etnE; 2-hydroxypropyl-CoM lyase [EC:4.4.1.23] path:map00625,path:map01120 Chloroalkane and chloroalkene degradation,Microbial metabolism in diverse environments 315.0 6.0 0.0 1.0 1.0 E 0.0 6.0 1.0 1.0 COG0620 Methionine_synthase_II_(cobalamin-independent) MetE 6.0 0.0 1.0 0.011137922229291 0.0260077352208587 0.0185728287250748 0.0148698129915677 0 0 0 0 K22364 0.0 0.0113960113960113 xecC; 2-oxopropyl-CoM reductase (carboxylating) [EC:1.8.1.5] 412.0 5.0 0.0 1.0 1.0 C 0.0 5.0 1.0 1.0 COG1249 Dihydrolipoamide_dehydrogenase_(E3)_component_of_pyruvate/2-oxoglutarate_dehydrogenase_complex_or_glutathione_oxidoreductase Lpd 5.0 0.0 1.0 0.0941683515656323 0.159008821918045 0.1265885867418386 0.0648404703524127 0 0 0 0 K22369 0.0 0.0085470085470085 EPHX4; epoxide hydrolase 4 [EC:3.3.-.-] path:map05207,path:map05208 Chemical carcinogenesis - receptor activation,Chemical carcinogenesis - reactive oxygen species 130.0 2.0 1.0 2.0 0.666666666666667 I 0.0 3.0 1.0 1.0 COG0596 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase_MenH_and_related_esterases,_alpha/beta_hydrolase_fold MenH 3.0 0.0 1.0 0 0 0 0 K22373 0.0257142857142857 0.0484330484330484 larA; lactate racemase [EC:5.1.2.1] path:map00620,path:map01100 Pyruvate metabolism,Metabolic pathways 318.0 29.0 0.0 1.0 1.0 S 9.0 20.0 1.0 1.0 COG3875 Nickel-dependent_lactate_racemase LarA 29.0 0.3103448275862069 0.6896551724137931 0.682074663399796 0.882661283810511 0.7823679736051535 0.2005866204107149 0 1 0 1 K22378 0.0028571428571428 0.0 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27] 67.0 1.0 0.0 1.0 1.0 O 1.0 0.0 1.0 1.0 KOG0800 1.0 1.0 0.0 0 0 0 0 K22390 0.0114285714285714 0.017094017094017 ACP7; acid phosphatase type 7 242.0 7.0 4.0 3.0 0.636363636363636 S 4.0 7.0 2.0 0.818181818181818 COG1409 3',5'-cyclic_AMP_phosphodiesterase_CpdA CpdA 11.0 0.3636363636363636 0.6363636363636364 0.0210585282336352 0.0526989025873341 0.0368787154104846 0.0316403743536988 0 0 0 0 K22391 0.0 0.1054131054131054 E3.5.4.16; GTP cyclohydrolase I [EC:3.5.4.16] path:map00790,path:map01100,path:map01240 Folate biosynthesis,Metabolic pathways,Biosynthesis of cofactors 30.0 25.0 14.0 3.0 0.675675675675676 S 0.0 46.0 2.0 0.530612244897959 COG0327 Putative_GTP_cyclohydrolase_1_type_2,_NIF3_family NIF3 46.0 0.0 1.0 0.043047144913303 0.0382683703009026 0.0406577576071028 0.0047787746124004 0 0 0 0 K22393 0.0 0.0113960113960113 nfr1; flavin reductase (NADH) subunit 1 [EC:1.5.1.36] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 181.0 4.0 3.0 2.0 0.8 S 0.0 5.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 5.0 0.0 1.0 8.96152277733107e-07 0.0006876459603734 0.0003442710563255 0.0006867498080956 0 0 0 0 K22394 0.0 0.0056980056980056 nfr2; flavin reductase (NADH) subunit 2 [EC:1.5.1.36] path:map00740,path:map01100 Riboflavin metabolism,Metabolic pathways 174.0 1.0 0.0 2.0 0.5 S 0.0 2.0 1.0 1.0 COG0431 NAD(P)H-dependent_FMN_reductase SsuE 2.0 0.0 1.0 0 0 0 0 K22396 0.0057142857142857 0.0427350427350427 yjhG, yagF; xylonate dehydratase [EC:4.2.1.82] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 525.0 16.0 14.0 3.0 0.8 EG 3.0 17.0 1.0 1.0 COG0129 Dihydroxyacid_dehydratase/phosphogluconate_dehydratase IlvD 20.0 0.15 0.85 0.0644637674678938 0.297308875096322 0.1808863212821078 0.2328451076284282 0 0 0 0 K22397 0.0028571428571428 0.0256410256410256 yjhH, yagE; 2-dehydro-3-deoxy-D-pentonate aldolase [EC:4.1.2.28] path:map00040,path:map01100 Pentose and glucuronate interconversions,Metabolic pathways 290.0 6.0 3.0 3.0 0.545454545454545 EM 1.0 10.0 1.0 1.0 COG0329 4-hydroxy-tetrahydrodipicolinate_synthase/N-acetylneuraminate_lyase DapA 11.0 0.0909090909090909 0.9090909090909092 0.573416228432099 0.0898318448819605 0.3316240366570298 0.4835843835501385 0 0 0 1 K22405 0.04 0.1225071225071225 fprA1_2; NADH oxidase (H2O-forming) [EC:1.6.3.4] 161.0 72.0 70.0 2.0 0.972972972972973 C 17.0 56.0 6.0 0.662162162162162 COG0426 Flavorubredoxin NorV 73.0 0.2328767123287671 0.7671232876712328 0.285740875701755 0.352197402709996 0.3189691392058755 0.066456527008241 0 0 0 0 K22408 0.0542857142857142 0.0028490028490028 dac; N,N'-diacetylchitobiose non-reducing end deacetylase [EC:3.5.1.136] 148.0 25.0 0.0 1.0 1.0 S 24.0 1.0 1.0 1.0 COG2120 N-acetylglucosaminyl_deacetylase,_LmbE_family LmbE 25.0 0.96 0.04 0.0217079028049328 0.040569619392473 0.0311387610987029 0.0188617165875402 0 0 0 0 K22409 0.0 0.0199430199430199 sle1; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 127.0 7.0 5.0 2.0 0.777777777777778 M 0.0 9.0 3.0 0.555555555555556 COG1388 LysM_repeat LysM 9.0 0.0 1.0 0.0361465531674858 0.473193034763489 0.2546697939654874 0.4370464815960032 0 0 0 0 K22424 0.0285714285714285 0.0484330484330484 E2.7.3.13; glutamine kinase [EC:2.7.3.13] 64.0 16.0 11.0 4.0 0.551724137931034 G 11.0 18.0 4.0 0.655172413793103 COG0574 Phosphoenolpyruvate_synthase/pyruvate_phosphate_dikinase PpsA 29.0 0.3793103448275862 0.6206896551724138 0.123238287869432 0.371246501875631 0.2472423948725315 0.248008214006199 0 0 0 0 K22430 0.04 0.0142450142450142 carC; caffeyl-CoA reductase-Etf complex subunit CarC [EC:1.3.1.108] 360.0 13.0 5.0 2.0 0.619047619047619 I 16.0 5.0 1.0 1.0 COG1960 Acyl-CoA_dehydrogenase_related_to_the_alkylation_response_protein_AidB CaiA 21.0 0.7619047619047619 0.238095238095238 0.194479565768483 0.211334680217733 0.2029071229931079 0.01685511444925 0 0 0 0 K22431 0.0028571428571428 0.0227920227920227 carD; caffeyl-CoA reductase-Etf complex subunit CarD [EC:1.3.1.108] 256.0 14.0 0.0 1.0 1.0 C 1.0 13.0 1.0 1.0 COG2086 Electron_transfer_flavoprotein,_alpha_and_beta_subunits FixA 14.0 0.0714285714285714 0.9285714285714286 0.0083252880126789 0.0431886086748342 0.0257569483437565 0.0348633206621553 0 0 0 0 K22432 0.08 0.1253561253561253 carE; caffeyl-CoA reductase-Etf complex subunit CarE [EC:1.3.1.108] 253.0 87.0 0.0 1.0 1.0 C 31.0 56.0 2.0 0.988505747126437 COG2025 Electron_transfer_flavoprotein,_alpha_subunit_FixB FixB 87.0 0.3563218390804598 0.6436781609195402 0.169425218201959 0.957370197872913 0.5633977080374359 0.787944979670954 0 0 0 0 K22441 0.0085714285714285 0.1082621082621082 paiA; diamine N-acetyltransferase [EC:2.3.1.57] 76.0 47.0 0.0 1.0 1.0 K 3.0 44.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 47.0 0.0638297872340425 0.9361702127659576 0.0178589099642532 0.0905183108719252 0.0541886104180892 0.072659400907672 0 0 0 0 K22443 0.0 0.0113960113960113 cntA; carnitine monooxygenase subunit [EC:1.14.13.239] 348.0 6.0 0.0 1.0 1.0 P 0.0 6.0 1.0 1.0 COG4638 Phenylpropionate_dioxygenase_or_related_ring-hydroxylating_dioxygenase,_large_terminal_subunit HcaE 6.0 0.0 1.0 5.72249074696613e-12 0.0616108092867125 0.0308054046462174 0.06161080928099 0 0 0 0 K22444 0.0 0.0056980056980056 cntB; carnitine monooxygenase subunit [EC:1.14.13.239] 318.0 2.0 0.0 1.0 1.0 C 0.0 2.0 1.0 1.0 COG1018 Flavodoxin/ferredoxin--NADP_reductase Fpr 2.0 0.0 1.0 0 0 0 0 K22445 0.0142857142857142 0.131054131054131 ald, crtNc; 4,4'-diapolycopenoate synthase [EC:1.2.99.10] path:map00906,path:map01110 Carotenoid biosynthesis,Biosynthesis of secondary metabolites 334.0 60.0 0.0 1.0 1.0 C 6.0 54.0 1.0 1.0 COG1012 Acyl-CoA_reductase_or_other_NAD-dependent_aldehyde_dehydrogenase AdhE 60.0 0.1 0.9 0.120541473787459 0.0499220939981592 0.0852317838928091 0.0706193797892998 0 0 0 0 K22446 0.3371428571428571 0.0256410256410256 K22446; tRNA (cytosine49-C5)-methyltransferase [EC:2.1.1.-] 256.0 131.0 0.0 1.0 1.0 J 122.0 9.0 1.0 1.0 COG0144 16S_rRNA_C967_or_C1407_C5-methylase,_RsmB/RsmF_family RsmB 131.0 0.931297709923664 0.0687022900763358 0.864721539287216 0.464377443015296 0.6645494911512559 0.4003440962719199 1 1 1 1 K22447 0.9371428571428572 0.0085470085470085 cct, ths; archaeal chaperonin 413.0 712.0 0.0 1.0 1.0 O 709.0 3.0 1.0 1.0 COG0459 Chaperonin_GroEL_(HSP60_family) GroEL 712.0 0.9957865168539326 0.0042134831460674 0.952742228165148 0.893900038618662 0.9233211333919048 0.058842189546486 0 0 1 1 K22451 0.0485714285714285 0.0968660968660968 jgt; 4-alpha-glucanotransferase [EC:2.4.1.25] path:map00500,path:map01100,path:map01110 Starch and sucrose metabolism,Metabolic pathways,Biosynthesis of secondary metabolites 402.0 56.0 0.0 1.0 1.0 G 20.0 36.0 1.0 1.0 COG1449 Alpha-amylase/alpha-mannosidase,_GH57_family 56.0 0.3571428571428571 0.6428571428571429 0.841800518254849 0.88052422658287 0.8611623724188595 0.0387237083280209 1 1 1 1 K22452 0.0 0.1196581196581196 tgpA; protein-glutamine gamma-glutamyltransferase [EC:2.3.2.13] 351.0 45.0 0.0 1.0 1.0 E 0.0 45.0 1.0 1.0 COG1305 Transglutaminase-like_enzyme,_putative_cysteine_protease YebA 45.0 0.0 1.0 0.0123007743373439 0.0258784018509666 0.0190895880941552 0.0135776275136227 0 0 0 0 K22457 0.0085714285714285 0.0455840455840455 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14] path:map00250,path:map01100 Alanine, aspartate and glutamate metabolism,Metabolic pathways 381.0 19.0 0.0 1.0 1.0 E 3.0 16.0 1.0 1.0 COG0436 Aspartate/methionine/tyrosine_aminotransferase AspB 19.0 0.1578947368421052 0.8421052631578947 0.0628089906776345 0.146963081555583 0.1048860361166087 0.0841540908779484 0 0 0 0 K22463 0.0 0.017094017094017 afsA; 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase [EC:2.3.1.277] 217.0 9.0 7.0 2.0 0.818181818181818 S 0.0 11.0 4.0 0.545454545454545 2DFYK 11.0 0.0 1.0 0.008569915885685 0.0196837695003246 0.0141268426930048 0.0111138536146396 0 0 0 0 K22465 0.0028571428571428 0.0227920227920227 bzaA_B; 5-hydroxybenzimidazole synthase [EC:4.1.99.23] path:map00860,path:map01100 Porphyrin metabolism,Metabolic pathways 418.0 14.0 0.0 1.0 1.0 H 1.0 13.0 1.0 1.0 COG0422 4-amino-2-methyl-5-hydroxymethylpyrimidine_(HMP)_synthase_ThiC ThiC 14.0 0.0714285714285714 0.9285714285714286 0.355500507408094 0.141567257992197 0.2485338827001455 0.213933249415897 0 0 0 0 K22466 0.0 0.0227920227920227 bzaF; 5-hydroxybenzimidazole synthase [EC:4.1.99.23] path:map00860 Porphyrin metabolism 426.0 8.0 0.0 1.0 1.0 H 0.0 8.0 1.0 1.0 COG0422 4-amino-2-methyl-5-hydroxymethylpyrimidine_(HMP)_synthase_ThiC ThiC 8.0 0.0 1.0 0.750657905650784 0.0816702543438145 0.4161640799972992 0.6689876513069696 0 0 1 1 K22468 0.0257142857142857 0.2222222222222222 ppk2; polyphosphate kinase [EC:2.7.4.34] path:map00190,path:map03018 Oxidative phosphorylation,RNA degradation 206.0 112.0 106.0 4.0 0.918032786885246 S 10.0 112.0 1.0 1.0 COG2326 Polyphosphate_kinase_2,_PPK2_family PPK2 122.0 0.081967213114754 0.918032786885246 0.0020889111924696 0.0102805341197289 0.0061847226560992 0.0081916229272593 0 0 0 0 K22469 0.2742857142857143 0.0028490028490028 fau-1, aubA; probable ribonuclease FAU-1 [EC:3.1.26.-] 324.0 97.0 0.0 1.0 1.0 J 96.0 1.0 1.0 1.0 COG1530 Ribonuclease_G_or_E CafA 97.0 0.9896907216494846 0.0103092783505154 0.959664951569576 0.691666178732252 0.8256655651509139 0.267998772837324 0 0 1 1 K22473 0.0028571428571428 0.0056980056980056 adhA; alcohol dehydrogenase (quinone), dehydrogenase subunit [EC:1.1.5.5] path:map00010,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 547.0 3.0 0.0 1.0 1.0 G 1.0 2.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 3.0 0.3333333333333333 0.6666666666666666 0 0 0 0 K22474 0.0 0.0028490028490028 adhB; alcohol dehydrogenase (quinone), cytochrome c subunit [EC:1.1.5.5] path:map00010,path:map00620,path:map01100,path:map01110,path:map01120 Glycolysis / Gluconeogenesis,Pyruvate metabolism,Metabolic pathways,Biosynthesis of secondary metabolites,Microbial metabolism in diverse environments 494.0 1.0 0.0 1.0 1.0 C 0.0 1.0 1.0 1.0 COG2010 Cytochrome_c,_mono-_and_diheme_variants CccA 1.0 0.0 1.0 0 0 0 0 K22476 0.0028571428571428 0.0541310541310541 K22476; N-acetylglutamate synthase [EC:2.3.1.1] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 165.0 20.0 0.0 1.0 1.0 K 1.0 19.0 1.0 1.0 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 20.0 0.05 0.95 0.0117055154493951 0.0302944217290262 0.0209999685892106 0.0185889062796311 0 0 0 0 K22477 0.0857142857142857 0.0398860398860398 argO; N-acetylglutamate synthase [EC:2.3.1.1] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 37.0 28.0 10.0 2.0 0.608695652173913 K 32.0 14.0 2.0 0.608695652173913 COG0454 N-acetyltransferase,_GNAT_superfamily_(includes_histone_acetyltransferase_HPA2) PhnO 46.0 0.6956521739130435 0.3043478260869565 0.289421215119233 0.397454647427495 0.3434379312733639 0.1080334323082619 0 0 0 0 K22478 0.0028571428571428 0.0398860398860398 K22478; bifunctional N-acetylglutamate synthase/kinase [EC:2.3.1.1 2.7.2.8] path:map00220,path:map01100,path:map01110,path:map01210,path:map01230 Arginine biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites,2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids 251.0 14.0 12.0 2.0 0.875 E 1.0 14.0 2.0 0.9375 COG0548 N-acetylglutamate_kinase ArgB 15.0 0.0666666666666666 0.9333333333333332 0.0291898276893505 0.0908691492405837 0.0600294884649671 0.0616793215512332 0 0 0 0 K22479 0.0057142857142857 0.0056980056980056 argA; N-acetyltransferase 188.0 4.0 0.0 1.0 1.0 J 2.0 2.0 1.0 1.0 COG1670 Protein_N-acetyltransferase,_RimJ/RimL_family RimL 4.0 0.5 0.5 0.270569791465208 0.321665956823929 0.2961178741445684 0.051096165358721 0 0 0 0 K22480 0.0542857142857142 0.0 hdrA1; heterodisulfide reductase subunit A1 [EC:1.8.7.3] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 590.0 21.0 0.0 1.0 1.0 C 21.0 0.0 2.0 0.904761904761905 COG1148 Heterodisulfide_reductase,_subunit_A_(polyferredoxin) HdrA 21.0 1.0 0.0 0.0278671334040213 0.0334512744592349 0.0306592039316281 0.0055841410552136 0 0 0 0 K22481 0.0714285714285714 0.0 hdrB1; heterodisulfide reductase subunit B1 [EC:1.8.7.3] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 291.0 31.0 0.0 1.0 1.0 C 31.0 0.0 1.0 1.0 COG2048 Heterodisulfide_reductase,_subunit_B HdrB 31.0 1.0 0.0 0.0115576277986529 0.0130098321906992 0.012283729994676 0.0014522043920463 0 0 0 0 K22482 0.0828571428571428 0.0056980056980056 hdrC1; heterodisulfide reductase subunit C1 [EC:1.8.7.3] path:map00680,path:map01100,path:map01120,path:map01200 Methane metabolism,Metabolic pathways,Microbial metabolism in diverse environments,Carbon metabolism 123.0 33.0 0.0 1.0 1.0 C 31.0 2.0 2.0 0.696969696969697 COG2048 Heterodisulfide_reductase,_subunit_B HdrB 33.0 0.9393939393939394 0.0606060606060606 0.20813074782621 0.636292111598659 0.4222114297124344 0.4281613637724489 0 0 0 0 K22486 0.0 0.0028490028490028 hilA; transcriptional regulator HilA, main transcriptional regulator of SPI1 458.0 1.0 0.0 1.0 1.0 K 0.0 1.0 1.0 1.0 COG0457 Tetratricopeptide_(TPR)_repeat TPR 1.0 0.0 1.0 0 0 0 0 K22487 0.0 0.0028490028490028 prgJ; type III secretion system protein path:map05130,path:map05131,path:map05132 Pathogenic Escherichia coli infection,Shigellosis,Salmonella infection 107.0 0.0 2.0 2.0 0.5 2EHBC 2.0 0.0 1.0 0 0 0 0 K22488 0.0 0.0028490028490028 prgH; type III secretion system protein 409.0 2.0 0.0 1.0 1.0 S 0.0 2.0 1.0 1.0 28NYF 2.0 0.0 1.0 0 0 0 0 K22489 0.0 0.017094017094017 hosA; MarR family transcriptional regulator, temperature-dependent positive regulator of motility 137.0 6.0 0.0 1.0 1.0 K 0.0 6.0 1.0 1.0 COG1846 DNA-binding_transcriptional_regulator,_MarR_family MarR 6.0 0.0 1.0 0.0126718343792584 0.0178776753733619 0.0152747548763101 0.0052058409941034 0 0 0 0 K22490 0.0 0.0142450142450142 ldrP; CRP/FNR family transcriptional regulator, LitR-dependent transcriptional activator 190.0 3.0 1.0 2.0 0.6 K 0.0 5.0 1.0 1.0 COG0664 cAMP-binding_domain_of_CRP_or_a_regulatory_subunit_of_cAMP-dependent_protein_kinases Crp 5.0 0.0 1.0 0.0187901259506308 1.10235128797628e-05 0.0094005747317552 0.018779102437751 0 0 0 0 K22491 0.0257142857142857 0.2193732193732193 litR; MerR family transcriptional regulator, light-induced transcriptional regulator 43.0 90.0 70.0 4.0 0.789473684210526 K 11.0 103.0 3.0 0.798245614035088 COG0789 DNA-binding_transcriptional_regulator,_MerR_family SoxR 114.0 0.0964912280701754 0.9035087719298246 0.0005440188639487 0.251356425366983 0.1259502221154658 0.2508124065030342 0 0 0 0 K22492 0.0 0.0056980056980056 CYP175A; beta-carotene 3-hydroxylase [EC:1.14.15.24] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 389.0 2.0 0.0 1.0 1.0 Q 0.0 2.0 1.0 1.0 COG2124 Cytochrome_P450 CypX 2.0 0.0 1.0 0 0 0 0 K22502 0.0828571428571428 0.0341880341880341 crtY; lycopene beta-cyclase [EC:5.5.1.19] path:map00906,path:map01100,path:map01110 Carotenoid biosynthesis,Metabolic pathways,Biosynthesis of secondary metabolites 148.0 26.0 13.0 3.0 0.604651162790698 H 30.0 13.0 3.0 0.604651162790698 arCOG04685 43.0 0.6976744186046512 0.3023255813953488 0.0245244555830331 0.0636602718431797 0.0440923637131064 0.0391358162601465 0 0 0 0 K22503 0.1942857142857142 0.0056980056980056 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12] path:map00970 Aminoacyl-tRNA biosynthesis 382.0 73.0 0.0 1.0 1.0 J 71.0 2.0 1.0 1.0 COG0017 Aspartyl/asparaginyl-tRNA_synthetase AsnS 73.0 0.9726027397260274 0.0273972602739726 0.994341292687163 0.987940470589447 0.9911408816383048 0.0064008220977159 0 0 1 1 K22504 0.0 0.0085470085470085 invG; type III secretion system outer membrane ring protein 507.0 4.0 0.0 1.0 1.0 NU 0.0 4.0 1.0 1.0 COG1450 Type_II_secretory_pathway_component_GspD/PulD_(secretin) PulD 4.0 0.0 1.0 0.0320415937813196 0.0510815524169596 0.0415615730991396 0.01903995863564 0 0 0 0 K22505 0.0 0.0056980056980056 prgK; type III secretion system inner membrane ring protein 225.0 3.0 0.0 1.0 1.0 M 0.0 3.0 1.0 1.0 COG4669 Type_III_secretory_pathway,_lipoprotein_EscJ EscJ 3.0 0.0 1.0 0 0 0 0 K22506 0.0 0.0056980056980056 spaL; type III secretion system ATPase [EC:7.4.2.8] 430.0 3.0 0.0 1.0 1.0 NU 0.0 3.0 1.0 1.0 COG1157 Flagellar_biosynthesis/type_III_secretory_pathway_ATPase_FliI FliI 3.0 0.0 1.0 0 0 0 0 K22507 0.0 0.0056980056980056 spaP; type III secretion system export apparatus protein 219.0 3.0 0.0 1.0 1.0 U 0.0 3.0 1.0 1.0 COG4790 Type_III_secretory_pathway,_EscR/YscR_component EscR 3.0 0.0 1.0 0 0 0 0 K22508 0.0 0.0056980056980056 spaQ; type III secretion system export apparatus protein 82.0 3.0 0.0 1.0 1.0 U 0.0 3.0 1.0 1.0 COG4794 Type_III_secretory_pathway,_EscS/YscS_component EscS 3.0 0.0 1.0 0 0 0 0 K22509 0.0 0.0085470085470085 spaR; type III secretion system export apparatus protein 224.0 4.0 0.0 1.0 1.0 U 0.0 4.0 1.0 1.0 COG4791 Type_III_secretory_pathway,_EscT/YscT_component EscT 4.0 0.0 1.0 0.0383834614866607 0.0664479150342862 0.0524156882604734 0.0280644535476254 0 0 0 0 K22510 0.0 0.0113960113960113 spaS; type III secretion system export apparatus switch protein 341.0 2.0 0.0 3.0 0.4 NU 0.0 5.0 1.0 1.0 COG1377 Flagellar_biosynthesis_protein_FlhB FlhB 5.0 0.0 1.0 0.0656276863621858 0.109495291399735 0.0875614888809604 0.0438676050375492 0 0 0 0 K22511 0.0 0.0056980056980056 invE; type III secretion system protein 341.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 28KVC 3.0 0.0 1.0 0 0 0 0 K22512 0.0 0.0056980056980056 spaK, invB; type III secretion system chaperone 130.0 3.0 0.0 1.0 1.0 S 0.0 3.0 1.0 1.0 2E8WA 3.0 0.0 1.0 0 0 0 0