variant	position	start	end	class	abundance_class	score	sd	expts	se	lower_ci	upper_ci	score1	score2	score3	score4	score5	score6	score7	score8	median_w_ave	exp1_w_ave	exp2_w_ave	exp3_w_ave	exp4_w_ave	exp5_w_ave	exp6_w_ave	exp7_w_ave	exp8_w_ave	hgvs	snv	splice_jxn	lit_destabilized	egfp_geomean	egfp_geomean_log10	egfp_geomean_lower_ci	egfp_geomean_upper_ci	sgfp_geomean	tm	ddg	xca	yca	zca	abs_tco	kappa	alpha	phi	psi	rsa	hbond_sum	helix	sheet	bfactor	schbond_unique_partners	schbond_partner_seq_dist	saltbridge_unique_partners	saltbridge_partner_seq_dist	crowding	substr_dist	grantham	hydro1	hydro2	hydrodiff	vol1	vol2	voldiff	polarity1	polarity2	polaritydiff	weight1	weight2	weightdiff	AA1_PI	AA2_PI	deltaPI	AA1_psic	AA2_psic	delta_psic	mut_msa_congruency	mut_mut_msa_congruency	seq_ind_closest_mut	evolutionary_coupling_avg	evolutionary_coupling_prop	evolutionary_coupling_avg_norm	gnomad_allele_freq	gnomad_allele_count	gnomad_allele_number	clinvar_disease	clinvar_interpretation	clinvar_review	clinvar_pathog	clinvar_likely_pathog	clinvar_uncertain	clinvar_likely_benign	clinvar_benign	cosmic_count	cancer_brain_count	cancer_uterine_count	cancer_breast_count	cancer_colorectal_count	cancer_nsclc_count	cancer_endometrial_count	cancer_melanoma_count	breast_cancer_expected	uterine_cancer_expected	endometrial_cancer_expected	nsclc_cancer_expected	colorectal_cancer_expected	brain_cancer_expected	melanoma_cancer_expected	pph2_hdiv_pred	pph2_hvar_pred	mut_assess_pred	NA	provean_pred	sift_pred	snap2_pred	fathmm_pred	ptenpred	lrt_pred	mut_taster_pred	metasvm_pred	metalr_pred	mcap_pred	cadd_pred	predictor_fraction_deleterious
M1V	1	M	V	missense	wt-like	1.06514337490303	0.128433544705692	4	0.064216772352846	0.939280813888047	1.19100593591802	1.13962183675086	1.1167815638303	NA	NA	1.13115727267123	0.873012826359732	NA	NA	0.812850132450409	0.849318025480029	0.823041029401602	NA	NA	0.802659235499216	0.721625918320326	NA	NA	p.Met1Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-1.475	-2.12	0.645	12.159	12.159	21.84	0.003419702	0.007462687	0.097740781	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	NA	DAMAGING	neutral	DAMAGING	NA	NA	NA	NA	NA	NA	NA	0.666666666666667
T2A	2	T	A	missense	possibly_wt-like	0.775537797739187	0.311177463000084	5	0.139162792066823	0.502783737300178	1.0482918581782	NA	0.437989765644213	NA	NA	0.446410679154254	1.0971905981094	0.915787659646951	0.980310286141115	0.780824455043746	NA	0.510129434204416	NA	NA	0.546880480486326	0.832117019717095	0.780824455043746	0.78652847929442	p.Thr2Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.851	-2.229	0.378	26.019	26.019	58.31	0.003014103	0.004987531	0.086148082	4.061e-06	1	246266	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.215	Neutral	TOLERATED	neutral	DAMAGING	NA	D	D	T	D	D	B	0.384615384615385
T2C	2	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.851	-3.785	1.934	12.712	12.712	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T2D	2	T	D	missense	wt-like	1.1906666666722	0.0899404447893619	3	0.0519271400101728	1.08889134243209	1.29244199091231	NA	NA	1.26892605943131	1.21066297297032	NA	1.09241096761497	NA	NA	0.829761270378181	NA	NA	0.916399689897461	0.826635393427826	NA	0.829761270378181	NA	NA	p.Thr2Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.851	-3.758	1.907	4.376	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2E	2	T	E	missense	possibly_low	0.666591677321777	0.529072895021952	7	0.199970757950438	0.274656193777741	1.05852716086581	0.695688907768648	0.984143325503208	1.01243644214804	0.883790874730871	-0.194343208886276	NA	0.0640079649195463	1.2204174350684	0.683285130967496	0.638105161921732	0.761897033775867	0.790603725537574	0.683285130967496	0.307534665108258	NA	0.322061539267252	0.907121828306705	p.Thr2Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.851	-2.113	0.262	9.067	9.067	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2F	2	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.851	-3.542	1.691	10.617	10.617	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2G	2	T	G	missense	wt-like	0.998610257421316	0.191288786533119	8	0.0676307990612573	0.866056327015587	1.13116418782705	0.788403477700201	0.683700585239486	1.11360192654902	1.24534515896025	0.952083070559923	0.94854521789865	1.11818555269943	1.13901706976358	0.799537178892163	0.68221657725133	0.623397986833107	0.840220586465326	0.841845319546122	0.735768247059678	0.758853771319	0.889834622976298	0.866238652996066	p.Thr2Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.851	-3.117	1.266	14.549	14.549	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2H	2	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.851	-4.923	3.072	1.725	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2I	2	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.851	-3.334	1.483	6.468	6.468	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T2K	2	T	K	missense	possibly_wt-like	0.947609505362395	0.200501674285613	2	0.141776093526613	0.669733468181451	1.22548554254334	NA	NA	NA	NA	NA	0.805833411835782	NA	1.08938559888901	0.764913181378678	NA	NA	NA	NA	NA	0.688515019572389	NA	0.841311343184967	p.Thr2Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.851	-3.199	1.348	7.769	7.769	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T2L	2	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.851	-2.381	0.53	11.927	11.927	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.745	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T2M	2	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.851	-3.716	1.865	4.622	4.622	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.295	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T2N	2	T	N	missense	wt-like	1.07298762291838	0.236144120378617	5	0.105606861130696	0.866001978581888	1.27997326725486	NA	0.723135655530546	1.20088775752058	1.32356814072625	0.955957794395522	NA	NA	1.16138876641898	0.876150128757376	NA	0.641576890562445	0.883030137192268	0.876150128757376	0.737215602983857	NA	NA	0.877474794172264	p.Thr2Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.851	-3.962	2.111	4.912	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T2P	2	T	P	missense	possibly_wt-like	0.84330989455836	0.521813378860969	6	0.213029419861163	0.425779903983019	1.2608398851337	NA	1.26502395482673	1.15061844611115	1.2103029636954	0.386463589097201	0.00338708961524779	NA	1.04406332400443	0.822512914746194	NA	0.891378276796895	0.858375429631636	0.826477510805462	0.524487974694242	0.293011142172175	NA	0.818548318686926	p.Thr2Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.851	-3.148	1.297	17.31	17.31	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.645	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T2Q	2	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.851	-3.021	1.17	6.211	6.211	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T2R	2	T	R	missense	possibly_wt-like	0.872829759842977	0.324894440336129	6	0.132637599848438	0.612864841144203	1.13279467854175	1.1939759471143	0.314214276862378	1.11094277379833	1.05528276083652	0.727213174353123	NA	NA	0.83534962609321	0.736107715686227	0.875178434894456	0.453071016962878	0.838916398451026	0.758493161923549	0.651770834533336	NA	NA	0.713722269448905	p.Thr2Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.851	-4.045	2.194	3.537	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.645	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T2S	2	T	S	missense	possibly_wt-like	0.824358714606725	0.42848946435079	7	0.161953794583352	0.506935110063757	1.14178231914969	0.271362057894632	1.22994386234188	1.10982582338947	1.22814616881073	0.390083060268401	0.460415203622513	NA	1.08073482591945	0.834302675908856	0.436220410430019	0.875206944543864	0.838368587372697	0.834302675908856	0.525839984092667	0.518267818121029	NA	0.836966509269754	p.Thr2Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.851	-2.32	0.469	19.646	19.646	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.49	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
T2T	2	T	T	synonymous	possibly_wt-like	0.915390540437152	0.674834178262778	4	0.337417089131389	0.254065197971289	1.57671588290302	NA	0.066592488895084	0.759641021718814	NA	1.65945922740996	NA	1.17586942372475	NA	0.793761181953928	NA	0.33892154007544	0.666619589121104	NA	1	NA	0.920902774786753	NA	p.Thr2=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T2V	2	T	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.851	-3.569	1.718	6.134	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T2W	2	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.851	-5.544	3.693	0.493	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T2X	2	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T2Y	2	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr2Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.851	-4.438	2.587	2.462	NA	58.31	0.003014103	0.004987531	0.086148082	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A3C	3	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.281	-5.251	2.97	1.651	NA	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.895	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A3D	3	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.281	-3.153	0.872	14.569	14.569	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-0.305	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
A3E	3	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.281	-3.271	0.99	7.814	7.814	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A3F	3	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.281	-3.653	1.372	9.565	9.565	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A3G	3	A	G	missense	possibly_wt-like	0.95555240323659	0.503089892735322	7	0.190150106183975	0.582865043459532	1.32823976301365	1.26571728109575	1.43683795711489	1.23912185368816	1.10659868678981	0.693417630567011	-0.0528330345151599	1.00000644791566	NA	0.826184137962323	0.909311277034494	0.970581640297853	0.901782143802799	0.780997840338805	0.639146920524217	0.265301778360814	0.826184137962323	NA	p.Ala3Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.281	-2.862	0.581	22.014	22.014	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
A3H	3	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.281	-3.824	1.543	9.312	9.312	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A3I	3	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.281	-3.263	0.982	9.615	7.816	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A3K	3	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.281	-2.187	-0.094	9.694	9.694	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A3L	3	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.281	-3.038	0.757	9.598	9.598	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A3M	3	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.281	-3.376	1.095	4.903	4.903	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.895	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A3N	3	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.281	-2.049	-0.232	17.369	17.369	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.935	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A3P	3	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.281	-4.223	1.942	2.637	NA	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
A3Q	3	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.281	-3.543	1.262	5.999	5.999	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A3R	3	A	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.281	-3.446	1.165	9.732	9.732	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A3S	3	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.281	-2.464	0.183	19.919	19.919	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-0.855	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
A3T	3	A	T	missense	possibly_wt-like	1.01743303014216	0.487006408676281	6	0.198819533787037	0.627753904496524	1.4071121557878	1.34660106981205	1.16841817304976	1.18768149950015	1.22371045277434	0.0340062637076627	1.144180722009	NA	NA	0.851060902858281	0.947793884462106	0.84684463723041	0.876553095427921	0.832357385804742	0.392831831039291	0.855277168486152	NA	NA	p.Ala3Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.281	-2.827	0.546	21.662	21.662	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
A3V	3	A	V	missense	wt-like	1.0807058044788	0.20339927365395	4	0.101699636826975	0.881378179057128	1.28003342990048	0.805629892916031	1.20818561380043	NA	NA	1.25771148604331	NA	1.05129622515543	NA	0.851870247272409	0.690412501115147	0.865176758147983	NA	NA	0.849932021438448	NA	0.85380847310637	NA	p.Ala3Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.281	-2.713	0.432	15.766	15.766	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
A3W	3	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.281	-5.632	3.351	0.682	NA	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.895	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A3X	3	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A3Y	3	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala3Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.281	-3.418	1.137	7.876	7.876	43.18	0.002564886	0.0025	0.073308712	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I4A	4	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.563	-2.622	0.059	11.356	11.356	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.97	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4C	4	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.563	-3.971	1.408	9.234	9.234	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4D	4	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.563	-4.178	1.615	3.714	NA	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4E	4	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.563	-3.975	1.412	6.277	NA	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4F	4	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.563	-2.742	0.179	19.703	19.703	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.42	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
I4G	4	I	G	missense	wt-like	1.32654792360808	0.0856756366748065	3	0.0494648518971921	1.22959859538897	1.42349725182718	NA	1.34546348968241	1.23299516010418	1.40118512103764	NA	NA	NA	NA	0.910189175096734	NA	0.928459548603466	0.898777291848569	0.910189175096734	NA	NA	NA	NA	p.Ile4Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.563	-3.161	0.598	14.423	14.423	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4H	4	I	H	missense	possibly_wt-like	0.901781112703275	0.345784305433013	3	0.199638661823298	0.51049652560784	1.29306569979871	0.524646461089838	NA	NA	NA	1.20389964633316	NA	NA	0.976797230686826	0.784764054018491	0.556727182063662	NA	NA	NA	0.829831263732854	NA	NA	0.784764054018491	p.Ile4His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.563	-3.928	1.365	13.002	13.002	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4K	4	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.563	-2.802	0.239	24.476	24.476	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I4L	4	I	L	missense	wt-like	1.09642752629364	0.124366013788616	6	0.0507722125210079	0.996915818337055	1.19593923425023	NA	0.917372879156999	1.02416285686975	1.2889785979189	1.12253266223886	NA	1.14243183907787	1.08308632249949	0.818792580556138	NA	0.731116981727429	0.796354974512195	0.860980831449582	0.799437617254234	NA	0.902893512621804	0.838147543858042	p.Ile4Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.563	-2.211	-0.352	31.402	31.402	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.28	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
I4M	4	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.563	-3.37	0.807	5.104	5.104	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
I4N	4	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.563	-4.266	1.703	3.707	NA	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
I4P	4	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.563	-2.629	0.066	22.343	22.343	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.38	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4Q	4	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.563	-3.442	0.879	6.583	6.583	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4R	4	I	R	missense	wt-like	1.02947980437247	0.314144652795128	5	0.140489759683595	0.754124935195934	1.304834673549	NA	1.1036701874396	0.807149364905166	0.61511071242475	1.38109913860642	NA	1.24036961848641	NA	0.816996905544169	NA	0.816996905544169	0.689920173018296	0.565455031696518	0.896021977132067	NA	0.955642153525384	NA	p.Ile4Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.563	-3.052	0.489	29.453	29.453	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.22	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I4S	4	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.563	-3.184	0.621	6.167	6.167	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
I4T	4	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.563	-2.895	0.332	13.486	13.486	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.425	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
I4V	4	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.563	-2.258	-0.305	24.384	24.384	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
I4W	4	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.563	-3.704	1.141	15.771	15.771	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.97	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I4X	4	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I4Y	4	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile4Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.563	-3.39	0.827	6.852	6.852	90.57	0.002961371	0	0.084640902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.38	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I5A	5	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.734	-2.181	0.447	11.356	11.356	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I5C	5	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.734	-5.07	3.336	1.401	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I5D	5	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.734	-4.251	2.517	1.374	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5E	5	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.734	-4.115	2.381	1.789	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5F	5	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.734	-3.165	1.431	15.303	15.303	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
I5G	5	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.734	-3.928	2.194	3.072	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5H	5	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.734	-5.221	3.487	0.881	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I5K	5	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.734	-4.075	2.341	2.2	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5L	5	I	L	missense	wt-like	1.12736552998196	0.162152826544262	4	0.0810764132721311	0.968458679972896	1.28627237999102	NA	NA	NA	NA	0.924720780620922	1.07867869514466	1.29697180757564	1.2090908365866	0.862213037266672	NA	NA	NA	NA	0.72554739671714	0.822993008306151	0.986127718591851	0.901433066227193	p.Ile5Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.734	-1.817	0.083	33.172	33.172	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
I5M	5	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.734	-2.978	1.244	6.712	6.712	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.88	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
I5N	5	I	N	missense	wt-like	1.19112836257228	0.416574657437124	5	0.18629785034662	0.825991285495672	1.55626543964889	1.23878088328159	1.41229925636941	1.38769907747319	1.45643459107176	0.460428004665443	NA	NA	NA	0.934418915331046	0.896495571451852	0.959269712229698	0.974652209055036	0.934418915331046	0.552116481806825	NA	NA	NA	p.Ile5Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.734	-4.365	2.631	1.542	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I5P	5	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.734	-3.169	1.435	13.627	13.627	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5Q	5	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.734	-4.497	2.763	1.445	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5R	5	I	R	missense	wt-like	1.17585040148735	0.222892527915909	4	0.111446263957955	0.957419737918217	1.39428106505649	1.07873018669759	NA	NA	NA	1.39466477773368	NA	1.32034016007809	0.909666481440054	0.860718232346007	0.820347208190067	NA	NA	NA	0.901089256501947	NA	0.998713758852351	0.751047765646653	p.Ile5Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.734	-4.366	2.632	2.161	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I5S	5	I	S	missense	wt-like	1.33624003089061	0.04432619231568	2	0.0313433511705964	1.27480819144145	1.39767187033977	1.36758338206121	NA	NA	NA	NA	NA	NA	1.30489667972001	0.953664070364268	0.957776775941636	NA	NA	NA	NA	NA	NA	0.9495513647869	p.Ile5Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.734	-3.324	1.59	6.167	6.167	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I5T	5	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.734	-2.267	0.533	7.506	7.506	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
I5V	5	I	V	missense	possibly_wt-like	0.937216796949558	0.705590972698021	5	0.315549875852595	0.318750404952387	1.55568318894673	NA	1.19043820932337	1.22468221787019	1.29585994288495	-0.322279940377467	NA	NA	1.29738355504675	0.863998655890018	NA	0.856995503365046	0.894700188860659	0.863998655890018	0.259745456354167	NA	NA	0.945777912518013	p.Ile5Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.734	-2.245	0.511	8.618	8.618	88.34	0.004002676	0	0.114403149	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Aug 30, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.435	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.571428571428571
I5W	5	I	W	missense	possibly_low	0.647629203119534	0.577559121383467	2	0.408395971266394	-0.152812191993852	1.44807059823292	NA	0.23923323185314	1.05602517438593	NA	NA	NA	NA	NA	0.615243971852619	NA	0.418506017111539	0.811981926593699	NA	NA	NA	NA	NA	p.Ile5Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.734	-5.598	3.864	0.711	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I5X	5	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile5Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I5Y	5	I	Y	missense	wt-like	1.1912772616792	0.221736325427439	6	0.0905234757894908	1.01385450937641	1.36870001398198	NA	1.04122882711139	0.955204878144055	NA	1.53512664696112	1.33111247250764	1.25439858029344	1.03059216505754	0.879596589239257	NA	0.788212489293422	0.76253436404855	NA	0.953557077996685	0.947410723197741	0.963198059663732	0.811782455280774	p.Ile5Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.734	-4.385	2.651	3.549	NA	88.34	0.004002676	0	0.114403149	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K6A	6	K	A	missense	wt-like	1.22457461389589	0.0425514146369646	2	0.0300883938388782	1.16560244561903	1.28354678217275	NA	NA	NA	NA	NA	1.25466300773477	NA	1.19448622005701	0.901914397899906	NA	NA	NA	NA	NA	0.909730869847336	NA	0.894097925952476	p.Lys6Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.397	-3.356	1.959	4.948	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6C	6	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.397	-5.343	3.946	1.436	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K6D	6	K	D	missense	wt-like	1.06253441688427	0.193313628120313	6	0.0789199582034846	0.907854141144038	1.21721469262451	NA	1.01581797287045	1.05955562967133	0.710043598625427	1.14406286987548	NA	1.18856903142696	1.257157398836	0.810596705662311	NA	0.776498513141818	0.813713447081586	0.607087995251012	0.807479964243037	NA	0.927742699587434	0.925574403721967	p.Lys6Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.397	-3.864	2.467	4.238	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K6E	6	K	E	missense	wt-like	1.26379869827676	0.296801070358298	4	0.148400535179149	0.972938994039163	1.55465840251437	1.162418307521	NA	NA	NA	1.65945922740996	NA	0.952118378340665	1.28119887983543	0.89890662091292	0.860164050985332	NA	NA	NA	1	NA	0.80039194009106	0.937649190840507	p.Lys6Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.397	-3.389	1.992	9.098	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K6F	6	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.397	-4.533	3.136	4.959	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6G	6	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.397	-3.651	2.254	3.518	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6H	6	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.397	-4.609	3.212	2.697	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K6I	6	K	I	missense	low	0.400210846470524	0.143206620552019	2	0.101262372503142	0.201740243375287	0.598681449565761	NA	0.501473218973666	0.298948473967382	NA	NA	NA	NA	NA	0.49003301624395	NA	0.539394237790772	0.440671794697128	NA	NA	NA	NA	NA	p.Lys6Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.397	-4.209	2.812	10.423	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K6L	6	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.397	-3.02	1.623	34.011	34.011	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6M	6	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.397	-4.706	3.309	4.514	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6N	6	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.397	-3.746	2.349	3.935	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
K6P	6	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.397	-4.061	2.664	2.177	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K6Q	6	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.397	-2.902	1.505	18.845	18.845	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K6R	6	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.397	-1.169	-0.228	28.77	28.77	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.425	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	B	0.285714285714286
K6S	6	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.397	-3.567	2.17	4.868	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6T	6	K	T	missense	possibly_wt-like	0.751407782883633	0.777392681721735	3	0.448827874058089	-0.1282786855279	1.63109425129517	1.10622680032096	NA	NA	NA	-0.140086440867581	1.28808298919752	NA	NA	0.833429451300223	0.833429451300223	NA	NA	NA	0.327801620367672	0.92620266601008	NA	NA	p.Lys6Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.397	-3.7	2.303	3.547	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K6V	6	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.397	-3.877	2.48	8.68	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K6W	6	K	W	missense	possibly_wt-like	0.781970263359893	0.199128432078634	6	0.0812938419788516	0.622637260916454	0.941303265803333	NA	0.763615339257298	0.8610789994219	NA	1.08008404594322	0.463723873988769	0.743113312324346	0.780206009223823	0.686924843738355	NA	0.660237343505252	0.716370095059843	NA	0.783581453337666	0.519898571384714	0.687823192454511	0.686026495022199	p.Lys6Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.397	-5.576	4.179	0.67	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K6X	6	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K6Y	6	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys6Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.397	-4.416	3.019	2.023	NA	90.57	0.003348648	0	0.095709949	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E7A	7	E	A	missense	possibly_low	0.365389901261011	0.311584546244975	2	0.220323545562755	-0.0664363129881589	0.797216115510181	NA	NA	NA	NA	0.145066355698256	NA	NA	0.585713446823766	0.51132997999965	NA	NA	NA	NA	0.434316976536794	NA	NA	0.588342983462506	p.Glu7Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.497	-2.694	0.197	10.638	10.638	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.355	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
E7C	7	E	C	missense	possibly_low	0.588206538085869	0.141641440880405	3	0.0817767240207086	0.427927104231609	0.74848597194013	NA	0.425305488689633	0.657018476870951	0.682295648697024	NA	NA	NA	NA	0.594919089044588	NA	0.504282195999142	0.616288109309407	0.594919089044588	NA	NA	NA	NA	p.Glu7Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.497	-3.922	1.425	18.828	18.828	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E7D	7	E	D	missense	wt-like	1.2213511481218	0.128992065751336	3	0.07447360388486	1.07538556670858	1.36731672953503	NA	1.36984399912078	1.13703705514453	1.1571723901001	NA	NA	NA	NA	0.851714402990126	NA	0.939698553141335	0.851714402990126	0.803177015870057	NA	NA	NA	NA	p.Glu7Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.497	-3.5	1.003	35.931	35.931	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
E7F	7	E	F	missense	low	0.573436771037096	0.12275829407183	8	0.0434016110925418	0.4883711764247	0.658502365649492	0.487394830042615	0.435758513809057	0.698138604786283	0.74812275070333	0.66474208189466	0.47871347677338	0.618379110868295	0.456244799419146	0.579822953202636	0.539003730722172	0.509100864659393	0.636455577297003	0.623787666082615	0.62843551836732	0.52728653723095	0.620642175683099	0.523317606865568	p.Glu7Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.497	-4.598	2.101	4.796	NA	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E7G	7	E	G	missense	wt-like	0.871459016953219	0.119763367192911	7	0.0452662979668794	0.782738703224677	0.960179330681762	0.8652665145514	0.970797811266707	0.927144714410995	1.00751824938065	0.896965236994492	NA	0.769721388175644	0.662799203892648	0.718786205353369	0.718786205353369	0.755744976311958	0.748772187652153	0.737545961809598	0.715179651246497	NA	0.702154126305488	0.627059155170075	p.Glu7Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.497	-2.671	0.174	42.636	42.636	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
E7H	7	E	H	missense	possibly_low	0.682055621789771	0.155884455762738	4	0.077942227881369	0.529291662267474	0.834819581312068	NA	0.486616983402872	0.796753399859722	0.626800465115365	0.818051638781127	NA	NA	NA	0.627701518559361	NA	0.532545763216529	0.684821446363412	0.57058159075531	0.685702437200157	NA	NA	NA	p.Glu7His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.497	-2.706	0.209	14.056	14.056	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.865	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E7I	7	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.497	-4.291	1.794	10.08	NA	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.905	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E7K	7	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.497	-2.498	0.001	24.407	24.407	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
E7L	7	E	L	missense	possibly_low	0.603116682973052	0.234684817278148	6	0.0958096754516279	0.41533316971739	0.790900196228714	0.21428058059732	0.754829144978039	0.539733677179724	0.898635306787456	0.535562392819494	NA	NA	0.675658995476278	0.606849989221712	0.409062383870142	0.656187055810289	0.558765490506403	0.689795179524247	0.580182017937487	NA	NA	0.633517960505936	p.Glu7Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.497	-3.065	0.568	32.893	32.893	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.21	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E7M	7	E	M	missense	possibly_low	0.571651262570928	0.539919882704896	2	0.381781010358078	-0.176625767712217	1.31992829285407	NA	NA	0.953432272929006	NA	0.189870252212851	NA	NA	NA	0.606358956082936	NA	NA	0.761664985456081	NA	0.451052926709791	NA	NA	NA	p.Glu7Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.497	-4.112	1.615	5.346	5.346	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.555	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E7N	7	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.497	-2.551	0.054	17.29	17.29	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.41	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E7P	7	E	P	missense	possibly_wt-like	0.877318712437865	0.159447887959274	2	0.112746682821875	0.656339274730629	1.0982981501451	NA	0.76457202961599	NA	NA	NA	NA	NA	0.990065395259741	0.726053162777335	NA	0.660678361659933	NA	NA	NA	NA	NA	0.791427963894737	p.Glu7Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.497	-4.331	1.834	2.389	NA	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.905	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E7Q	7	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.497	-2.732	0.235	9.768	9.768	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
E7R	7	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.497	-2.432	-0.065	17.159	17.159	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.085	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E7S	7	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.497	-2.597	0.1	12.06	12.06	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.755	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E7T	7	E	T	missense	wt-like	1.12981336000742	0.151453008365547	2	0.107093449246381	0.919914056504341	1.33971266351049	NA	1.2369068092538	1.02271991076103	NA	NA	NA	NA	NA	0.837032011963546	NA	0.878416745886931	0.795647278040161	NA	NA	NA	NA	NA	p.Glu7Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.497	-2.63	0.133	9.702	9.702	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.01	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E7V	7	E	V	missense	low	0.567176989168684	0.15494414969778	7	0.0585633838863841	0.452394865938578	0.68195911239879	0.562144196433751	0.257061997797195	0.597369965705285	0.534895260392545	0.743415868272249	NA	0.687150368069988	0.588201267509775	0.587033350133602	0.574567724050707	0.42672477816148	0.587033350133602	0.530276421579213	0.657823153621487	NA	0.657681920432544	0.589592486568132	p.Glu7Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.497	-3.25	0.753	13.695	13.695	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.555	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E7W	7	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.497	-4.285	1.788	13.43	13.43	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E7X	7	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu7Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	6	0	4	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E7Y	7	E	Y	missense	possibly_low	0.405577889528773	0.335358092221958	4	0.167679046110979	0.0769329981892234	0.734222780868322	NA	-0.0290297253868086	NA	NA	0.313767113275284	NA	0.64118281735578	0.696391352870836	0.565128596185337	NA	0.294841308571183	NA	NA	0.497333091040055	NA	0.632924101330619	0.64393074672367	p.Glu7Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.497	-3.634	1.137	7.01	7.01	90.57	0.003491642	0	0.099796944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.905	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8A	8	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.207	-2.274	0.067	10.638	10.638	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.835	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8C	8	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.207	-5.158	2.951	1.69	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8D	8	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.207	-4.282	2.075	1.669	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8E	8	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.207	-4.018	1.811	2.717	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8F	8	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.207	-3.246	1.039	34.433	34.433	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.18	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
I8G	8	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.207	-3.959	1.752	2.878	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8H	8	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.207	-5.172	2.965	1.527	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I8K	8	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.207	-2.646	0.439	10.038	10.038	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8L	8	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.207	-1.808	-0.399	32.147	32.147	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-1.035	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
I8M	8	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.207	-2.376	0.169	14.549	14.549	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
I8N	8	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.207	-4.358	2.151	1.93	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
I8P	8	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.207	-4.372	2.165	1.547	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I8Q	8	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.207	-3.154	0.947	5.627	5.627	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8R	8	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.207	-3.41	1.203	10.244	10.244	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I8S	8	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.207	-3.839	1.632	4.057	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
I8T	8	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.207	-2.807	0.6	10.801	10.801	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.835	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
I8V	8	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.207	-2.264	0.057	24.384	24.384	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.29	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
I8W	8	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.207	-3.774	1.567	11.952	11.952	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I8X	8	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I8Y	8	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile8Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.207	-4.386	2.179	7.986	NA	58.31	0.003683011	0	0.105266588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V9A	9	V	A	missense	possibly_wt-like	0.969095948837096	0.474547022716938	6	0.193733010768906	0.58938622511353	1.34880567256066	1.02173343455875	1.33322310349436	1.17974040486977	1.33459621434031	0.0728168922118245	NA	NA	0.87246564354756	0.832943928941981	0.793229491871148	0.922816936571076	0.872658366012815	0.880986507437362	0.407329068899323	NA	NA	0.732363717097655	p.Val9Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-0.993	-2.59	1.597	7.691	7.691	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V9C	9	V	C	missense	wt-like	1.22088226617483	0.0699483679344558	7	0.0264379980242021	1.16906474222405	1.2726997901256	1.21613468036399	1.22944809989508	1.25915723932306	1.33913343001536	1.14491793454239	1.22603061872705	1.13135386035686	NA	0.885721039862332	0.885721039862332	0.87497840639935	0.911608548021264	0.882976310364443	0.80779936324119	0.895618747256448	0.896926986476113	NA	p.Val9Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-0.993	-3.524	2.531	10.553	10.553	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9D	9	V	D	missense	wt-like	1.14605875158312	0.23492082215105	3	0.135631599907157	0.880225700599547	1.41189180256669	NA	1.32247309757489	NA	NA	0.879396327680048	NA	NA	1.23630682949442	0.915102245783533	NA	0.917861364760061	NA	NA	0.708616999027518	NA	NA	0.915102245783533	p.Val9Asp	1	0	NA	1.51932898791512	0.41604712157803	1.41962765798474	1.6190303178455	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-0.993	-4.144	3.151	1.24	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V9E	9	V	E	missense	wt-like	1.25317569968913	0.0525192858139466	8	0.018568371571058	1.2167823601583	1.28956903921996	1.27527959577212	1.34101343045571	1.21598762026651	1.30424277979983	1.17746499899757	1.25055771422211	1.21740367483741	1.2434557831618	0.910784142307019	0.913860801823458	0.926408146192491	0.890435902056925	0.867674961938722	0.819956922993201	0.90770748279058	0.943272848014588	0.918692793872314	p.Val9Glu	0	0	NA	1.3172273094883	0.269467082758293	1.17443363084952	1.46002098812707	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-0.993	-3.971	2.978	1.306	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9F	9	V	F	missense	wt-like	1.00943401369819	0.107358582462941	7	0.040577730043623	0.929903124238297	1.08896490315808	NA	1.00178191182532	0.997176463307982	1.09459347797965	1.00841925224469	1.13293997564274	0.795529848531321	1.03559716635562	0.7757329375126	NA	0.770028125220731	0.783119431340292	0.7757329375126	0.756811941982641	0.849736911587187	0.716054392533672	0.814296207457846	p.Val9Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-0.993	-4.084	3.091	1.38	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V9G	9	V	G	missense	wt-like	1.1325542563515	0.0649204378563008	8	0.0229528409228951	1.08756751479975	1.17754099790325	1.17125840742096	1.02912376091806	1.13147899447001	1.12073380744763	1.25818375631533	1.09688899860701	1.13056276819156	1.12220355744142	0.849548435348205	0.864369962942102	0.782632257501224	0.848988438446503	0.787196819288432	0.850108432249906	0.831968369559055	0.896500909462717	0.857794099101496	p.Val9Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-0.993	-3.817	2.824	2.081	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V9H	9	V	H	missense	wt-like	1.04534414075254	0.115741753868682	5	0.0517612858970842	0.943893884600776	1.14679439690431	1.18674351836665	0.955593625315836	0.908719718819224	1.12819910902066	NA	1.04746473224034	NA	NA	0.790470738798855	0.871737415121999	0.748736102468351	0.739735603195661	0.790470738798855	NA	0.807608498444454	NA	NA	p.Val9His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-0.993	-5.145	4.152	0.489	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9I	9	V	I	missense	wt-like	0.934739581199378	0.114682372848365	4	0.0573411864241823	0.822352920977184	1.04712624142157	NA	NA	NA	0.767510940784895	1.02507422806487	0.959511231447228	NA	0.986861924500518	0.763645912692334	NA	NA	NA	0.632290386724091	0.763033205469585	0.764258619915084	NA	0.789819026930372	p.Val9Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-0.993	-1.732	0.739	8.355	8.355	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.63	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
V9K	9	V	K	missense	wt-like	1.23948276861325	0.154409443736704	6	0.0630373914369855	1.11593175171741	1.3630337855091	NA	1.27397997814858	1.27691195201479	1.39769141729833	1.29930984208174	NA	1.24611323933542	0.942890182800657	0.902081929379844	NA	0.895506852822345	0.920316390578968	0.908657005937343	0.865470580985627	NA	0.958735629765916	0.767734305100222	p.Val9Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-0.993	-3.981	2.988	1.372	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9L	9	V	L	missense	wt-like	0.913446799110072	0.109972650144828	8	0.0388812033312316	0.837241040905279	0.989652557314865	0.709013992743115	0.861095813841993	0.928601861580022	0.940957589004737	0.8838703044253	1.09545594829093	0.904081653693084	0.984497229301394	0.729887523825475	0.644444924464392	0.705174201735401	0.749486849069187	0.708355681618015	0.710288198581764	0.831262058194886	0.774519677579883	0.788631363361296	p.Val9Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-0.993	-2.952	1.959	5.157	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.928571428571429
V9M	9	V	M	missense	possibly_wt-like	0.8735707464757	0.274905753882021	6	0.112229804061015	0.653604372524125	1.09353712042728	0.578484491965855	1.08201519649795	1.25193771565842	0.817326640541788	0.564401047553182	NA	NA	0.947259386637007	0.712032933933138	0.582342052976108	0.807014319164018	0.908067714863057	0.654137138628759	0.590954346378208	NA	NA	0.769928729237516	p.Val9Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-0.993	-4.359	3.366	1.136	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9N	9	V	N	missense	wt-like	1.27006405053653	0.117347293335493	4	0.0586736466677465	1.15506581622611	1.38506228484694	NA	1.16695172140502	1.2794474728178	1.43138025523089	NA	NA	NA	1.20247675269239	0.909835549221414	NA	0.846168627701921	0.92155994300011	0.923431297734124	NA	NA	NA	0.898111155442717	p.Val9Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-0.993	-4.329	3.336	1.392	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9P	9	V	P	missense	wt-like	1.2918063120445	0.149913857446899	8	0.0530025525972677	1.18792321786516	1.39568940622383	1.30657544304453	1.36156846338078	1.32685717609598	1.40896754880628	1.46919990015998	0.977568703143881	1.27406880146537	1.20964446025919	0.928840787653991	0.928750631093485	0.93588367043881	0.944812148711453	0.913602170789	0.928930944214498	0.773158654564514	0.973792310823582	0.901711122641041	p.Val9Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-0.993	-4.192	3.199	0.772	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9Q	9	V	Q	missense	possibly_wt-like	0.958464574381179	0.305043572385136	5	0.136419632790508	0.691087007327603	1.22584214143475	1.33111253618068	0.524200733785291	0.808769811579328	NA	1.06094799552097	NA	NA	1.06729179483962	0.7764334146337	0.940424803848734	0.54987123962488	0.690714925079721	NA	0.7764334146337	NA	NA	0.830214773030184	p.Val9Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-0.993	-4.423	3.43	0.837	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9R	9	V	R	missense	wt-like	1.05344287494273	0.111559459824897	8	0.0394422252738464	0.976137533935875	1.13074821594958	1.22115573573542	1.05252427295996	1.03333285123057	0.934328880101755	0.931206310694074	0.964369165192154	1.09713881267628	1.19348697095163	0.797135960279149	0.88810994010795	0.793419499732241	0.800852420826057	0.705448651112402	0.727969987531633	0.766652962787707	0.878498987857995	0.893596055030874	p.Val9Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-0.993	-4.38	3.387	1.002	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9S	9	V	S	missense	wt-like	1.17074202831357	0.297685709694568	8	0.10524779199368	0.964460146553598	1.37702391007355	1.05849659510718	1.22926971271508	1.30616199365399	1.38979068261645	1.39283918006652	0.481664370929938	1.25447196725952	1.25324172415991	0.902799726640593	0.810720540419157	0.87489617291155	0.93466214552431	0.905192126565937	0.90040732671525	0.528740952371749	0.963237585398783	0.923607763724192	p.Val9Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-0.993	-3.129	2.136	5.566	5.566	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9T	9	V	T	missense	wt-like	1.14678908985732	0.140460802924111	6	0.0573428826709498	1.03439910505256	1.25917907466209	NA	1.16079721420473	1.20298350737733	1.25990786049637	0.877434925600183	1.24567947128691	NA	1.13393156017841	0.855958140218579	NA	0.84333150346023	0.884058002869949	0.84823181474892	0.707884341155514	0.905303130072714	NA	0.863684465688237	p.Val9Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-0.993	-3.524	2.531	2.079	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9V	9	V	V	synonymous	wt-like	1.1904177965393	0.102042747759	4	0.0510213738794999	1.09041774129372	1.29041785178487	NA	NA	NA	NA	1.09005888138659	1.2790858362944	1.27761400467759	1.1149124637986	0.887950188271381	NA	NA	NA	NA	0.787307431700052	0.921768215056528	0.975701733850128	0.854132161486235	p.Val9=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V9W	9	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val9Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-0.993	-5.59	4.597	0.164	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V9X	9	V	X	nonsense	wt-like	1.02265246680904	0.183195101575078	7	0.069241240024696	0.886942130115742	1.15836280350234	0.772272620323187	1.1348497000896	1.16447679419873	1.26255147229561	0.842676118437665	NA	0.907183330357183	1.0745572319613	0.831370136138374	0.674541894082274	0.831370136138374	0.865172290575084	0.849391174777828	0.694900611837346	NA	0.776190220138043	0.833863824707552	p.Val9Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V9Y	9	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val9Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-0.993	-4.243	3.25	0.626	NA	21.59	0.002151004	0.002538071	0.061479265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S10A	10	S	A	missense	possibly_wt-like	0.885401412141455	0.432373635157071	7	0.163421873155226	0.565100426471138	1.20570239781177	NA	0.952683246810157	1.12386232343129	0.956569183318707	1.28822886374391	-0.0304895222777356	1.10319677251928	0.803759017444576	0.74739446695762	NA	0.74739446695762	0.845252823380769	0.715202170365097	0.861331416409406	0.276314285340953	0.881761765003815	0.697855947636768	p.Ser10Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-0.988	-2.111	1.123	7.619	7.619	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S10C	10	S	C	missense	wt-like	1.30472667068635	0.330645710170358	3	0.190898389773251	0.930572702024086	1.67888063934861	NA	1.4026813221593	NA	1.57532758317201	NA	NA	NA	0.936171106727725	0.954836006424428	NA	0.954836006424428	NA	0.986559620255269	NA	NA	NA	0.764359662197988	p.Ser10Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-0.988	-4.93	3.942	0.818	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S10D	10	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-0.988	-2.972	1.984	8.368	8.368	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S10E	10	S	E	missense	possibly_wt-like	0.814330234896696	0.586241259995118	7	0.22157836889032	0.380044612118538	1.24861585767485	0.967461507318756	1.24526987022249	1.21628353833224	1.16543109924057	-0.201128316268973	NA	0.160959810175353	1.14603413525644	0.806798885491985	0.767408183257102	0.882271976246872	0.890581035800911	0.806798885491985	0.305000170836353	NA	0.374279162550347	0.869762960505454	p.Ser10Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-0.988	-3.503	2.515	9.355	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S10F	10	S	F	missense	wt-like	0.936727517123373	0.141789687617204	3	0.0818623143141059	0.776280329376627	1.09717470487012	0.980484426597046	NA	NA	1.05148110536903	NA	0.778217019404046	NA	NA	0.756825940059142	0.773604182456716	NA	NA	0.756825940059142	NA	0.674903653946919	NA	NA	p.Ser10Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-0.988	-4.274	3.286	3.324	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S10G	10	S	G	missense	wt-like	1.03922311490644	0.158507952491821	8	0.0560410240394809	0.929384726132317	1.14906150368057	1.07450965498039	1.1189738975697	1.15872298196856	1.27667616133023	0.848988797857254	0.823153444142748	0.927097701789356	1.08566227961331	0.821195418330687	0.818339178301921	0.824051658359453	0.862350319198985	0.855585578923027	0.697258636394204	0.697051590486125	0.786915969014932	0.839441313313284	p.Ser10Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-0.988	-2.558	1.57	13.031	13.031	90.57	0.001365422	0	0.039026026	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jun 28, 2012)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S10H	10	S	H	missense	wt-like	1.17348771948821	0.124251348373464	6	0.0507254005612966	1.0740677612867	1.27290767768972	NA	1.31693436551938	1.2100355338563	1.18385479057397	0.949599063675942	NA	1.14290329081117	1.2375992724925	0.895332060015715	NA	0.915308102496885	0.887516686621008	0.814878623720961	0.734840376524441	NA	0.903147433410421	0.915751372768059	p.Ser10His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-0.988	-4.715	3.727	2.773	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S10I	10	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-0.988	-4.034	3.046	2.356	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S10K	10	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-0.988	-3.568	2.58	8.187	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S10L	10	S	L	missense	wt-like	0.921699530677072	0.105689518014056	8	0.0373668874440386	0.848461777072395	0.99493728428175	0.92868060806063	0.989826164059222	0.973006973920763	0.877823031024579	0.985201355090426	0.772061531851855	1.06929585838558	0.777700723023518	0.748548160563774	0.748957142009827	0.764516726710522	0.771265445756956	0.680667923912422	0.748139179117721	0.67186978223891	0.86350295663854	0.684768219895953	p.Ser10Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-0.988	-3.605	2.617	4.276	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S10M	10	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-0.988	-4.771	3.783	1.956	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S10N	10	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-0.988	-3.607	2.619	4.046	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S10P	10	S	P	missense	wt-like	1.01837664256298	0.191451965142633	4	0.0957259825713164	0.830757164338496	1.20599612078747	1.2149869028313	1.04933799877485	0.755505381417564	NA	1.05367628722823	NA	NA	NA	0.782833918735717	0.8851749542634	0.791950680956492	0.664591254152025	NA	0.773717156514941	NA	NA	NA	p.Ser10Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-0.988	-3.946	2.958	2.238	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S10Q	10	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-0.988	-3.214	2.226	19.376	19.376	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S10R	10	S	R	missense	wt-like	0.886130542932542	0.197915910767086	7	0.074805182913223	0.739515078565694	1.03274600729939	0.850124364150769	0.94204810092174	1.04152500910497	0.850478582537357	0.475807678443026	1.03113003277908	NA	1.01180003259085	0.742491843687874	0.711581925747709	0.742491843687874	0.804870284827391	0.668675973884907	0.557861371739216	0.79955757118091	NA	0.80234414326314	p.Ser10Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-0.988	-3.977	2.989	6.572	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	3	0	0	0	0	0.00093504207689346	0.000866690123354582	0.000866690123354582	0.00139122286577568	0.000791779931602594	0.000543045589468079	0.000165477839033609	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S10T	10	S	T	missense	wt-like	1.1784773925171	0.289671401716307	5	0.129544989075062	0.924573879552338	1.43238090548185	1.33319690380481	1.21258092557102	1.16422632992927	1.47531125569468	0.707071547585702	NA	NA	NA	0.867202922903064	0.941416497020967	0.867202922903064	0.865049449757398	0.942697305694265	0.64424717502589	NA	NA	NA	p.Ser10Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-0.988	-2.85	1.862	6.041	6.041	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
S10V	10	S	V	missense	possibly_wt-like	0.751701604219548	0.655846163947866	4	0.327923081973933	0.108984173851264	1.39441903458783	1.12962527904084	NA	NA	NA	-0.195403050217482	NA	0.825833608726264	1.24675057932857	0.788468847803256	0.844561898052176	NA	NA	NA	0.307138774279777	NA	0.732375797554337	0.92034759884517	p.Ser10Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-0.988	-3.708	2.72	3.083	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S10W	10	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-0.988	-5.476	4.488	0.696	NA	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S10X	10	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S10Y	10	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser10Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-0.988	-3.34	2.352	8.033	8.033	90.57	0.001365422	0	0.039026026	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R11A	11	R	A	missense	wt-like	1.08106232722701	0.196443290640113	8	0.0694531914651117	0.944936573344027	1.21718808110999	1.20749243844342	0.768401043844092	0.870896479912313	0.915960846364241	1.20019387491106	1.25740034118694	1.26037373286509	1.16777986028893	0.854565863288258	0.881609264086219	0.662443472778467	0.72118510254029	0.697393321607881	0.828447017926185	0.911080026749291	0.96641623736032	0.880684708650331	p.Arg11Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.365	-2.752	0.387	7.188	7.188	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11C	11	R	C	missense	possibly_wt-like	0.958773324875441	0.451365925587381	6	0.184269367494688	0.597612001131878	1.319934648619	0.931567072906417	1.13834876600804	1.24595409978751	1.219637752919	NA	0.0654937270768305	NA	1.15163853055485	0.831777221822674	0.750330454205966	0.832983146639038	0.905133035725506	0.830571297006309	NA	0.323621807643696	NA	0.87257775715455	p.Arg11Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.365	-5.468	3.103	0.971	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R11D	11	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg11Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.365	-3.816	1.451	3.652	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11E	11	R	E	missense	wt-like	0.988518721063336	0.265716677931082	8	0.0939450324197149	0.804389840994247	1.17264760113242	0.828651578666662	1.19016166371806	1.12721604792573	1.2628031156865	0.547105478377525	1.14935004786713	0.680444180947353	1.12241765531772	0.8481995995959	0.701365678619862	0.856868020495141	0.846897665817061	0.849501533374739	0.584493797040872	0.857824988027246	0.654070012356821	0.857901629343867	p.Arg11Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.365	-2.212	-0.153	9.067	9.067	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R11F	11	R	F	missense	wt-like	0.979032041983524	0.287115235848068	6	0.117214304201102	0.749296227276442	1.20876785669061	0.950291667492517	0.931334190221293	1.06606796158868	1.24692775747535	0.458372146896499	NA	NA	1.2211985282268	0.788073306470595	0.759239176635198	0.737552911165361	0.816907436305993	0.842539370564033	0.551348541161917	NA	NA	0.907514130827822	p.Arg11Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.365	-4.637	2.272	11.894	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11G	11	R	G	missense	wt-like	1.11306363261211	0.099682882256683	8	0.0352432210059604	1.04398818874124	1.18213907648297	1.04302656446129	1.17710930581133	1.24981289010957	0.931833383736371	1.07885922117338	1.17023156190514	1.08105533869312	1.17258079500664	0.859484009593827	0.803360263091802	0.850851103165566	0.907025588940593	0.704354247335288	0.783123934953921	0.868116916022089	0.869836535035979	0.883095968783924	p.Arg11Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.365	-1.907	-0.458	18.471	18.471	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
R11H	11	R	H	missense	wt-like	1.22264894303896	0.166036931871479	5	0.0742539732880257	1.07711382968543	1.36818405639249	1.09677339125398	1.08354386844568	1.13714994063479	1.45423638452553	NA	1.34154113033483	NA	NA	0.851769767956788	0.828931741242976	0.807719011205048	0.851769767956788	0.933454888462306	NA	0.952550723833947	NA	NA	p.Arg11His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.365	-4.855	2.49	4.268	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11I	11	R	I	missense	wt-like	1.04163539773415	0.188156184098901	8	0.0665232568492586	0.911252210175291	1.172018585293	1.08855239728191	1.30634905065341	1.18345435144087	1.21425282601675	0.890162820009691	0.80666474821348	0.824946252717127	1.01870073553994	0.815415196630197	0.825020385349379	0.910428450489854	0.874479880253589	0.828209729014045	0.712638691183425	0.688924762569146	0.731897873470676	0.805810007911014	p.Arg11Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.365	-4.369	2.004	3.878	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R11K	11	R	K	missense	wt-like	1.01207032250173	0.25916620205557	8	0.0916290894639283	0.832480607216233	1.19166003778723	0.94421574953291	0.99338672221834	0.958332229989525	0.507191187295757	1.37647048077413	1.2108018226546	1.17913806749174	0.927026320056852	0.7651131327805	0.756348397539499	0.766158084099252	0.764068181461748	0.518126757624918	0.894292998340595	0.888112889571008	0.922663244723355	0.759766710861177	p.Arg11Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.365	-1.904	-0.461	24.063	24.063	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-1.445	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
R11L	11	R	L	missense	wt-like	1.10864139555294	0.0689036628423508	8	0.0243611236222089	1.06089447063049	1.1563883204754	0.978200605634226	1.10271191960375	1.15502121585858	1.2198437354715	1.13317309328229	1.09205171724411	1.08055518604048	1.10757369128861	0.830122918326843	0.772517594069327	0.81655516019907	0.86053477889536	0.830661630972174	0.803412220751144	0.829584205681513	0.869567156121832	0.850446277252578	p.Arg11Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.365	-3.064	0.699	11.927	11.927	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11M	11	R	M	missense	wt-like	0.936241167822425	0.173835504840655	5	0.0777416011453398	0.783870429477081	1.08861190616777	NA	0.836593447755914	1.12039619038746	0.775650540967177	0.818801794234213	NA	NA	1.12976386576736	0.693879023333734	NA	0.693879023333734	0.843552849894642	0.635860020928836	0.685982648638481	NA	NA	0.861591249268259	p.Arg11Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.365	-4.948	2.583	1.603	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11N	11	R	N	missense	possibly_wt-like	0.75522575917336	0.458659254043081	6	0.187246856368518	0.38822866447272	1.122222853874	1.06433590627357	1.15167413374146	0.674399795692179	0.423517145212173	NA	0.0431935827505899	NA	1.17423399137019	0.719155783741171	0.813498747558437	0.839125916904083	0.624812819923904	0.481431377510179	NA	0.312630675522601	NA	0.883926283445299	p.Arg11Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.365	-3.949	1.584	3.644	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R11P	11	R	P	missense	wt-like	1.14227568022792	0.0891651336993845	8	0.03152463534212	1.08048853033161	1.20406283012423	1.30902663124011	1.03192122970622	1.04877946055719	1.18091236902193	1.12275178771906	1.09099259841749	1.17342337619318	1.18039798896819	0.821325207575433	0.929916848880246	0.783921843532397	0.808428248405022	0.813588220214437	0.799519468910083	0.829062194936429	0.919585349747557	0.887022139262033	p.Arg11Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.365	-4.206	1.841	2.356	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11Q	11	R	Q	missense	wt-like	1.09969075454665	0.221033374544037	6	0.090236497293062	0.922830469761207	1.2765510393321	1.25394586313097	1.02620513179973	1.28082889269083	0.937433656933872	NA	1.32462036713148	NA	0.77511061559305	0.842498765685041	0.903710712773167	0.781286818596915	0.922237463778352	0.706810255777229	NA	0.944210941757337	NA	0.683467343471668	p.Arg11Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.365	-1.994	-0.371	6.742	6.742	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.615	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R11R	11	R	R	synonymous	wt-like	1.00550503402902	0.0960088058258642	8	0.0339442388265455	0.938975548446367	1.07203451961168	0.954495834961139	0.905198078212015	0.966281727177128	1.08953097625104	1.09470007600668	1.12063698240508	0.863682405345272	1.04951419187382	0.770739900754447	0.761239420798121	0.725504603388322	0.767967031931731	0.773512769577162	0.789041093456003	0.843673102215297	0.752760909342103	0.821286006483103	p.Arg11=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R11S	11	R	S	missense	possibly_wt-like	0.820208522022303	0.508680718238575	8	0.17984579266267	0.467717245632412	1.17269979841219	0.0240007453374742	1.21693681392854	1.21070507250691	1.13222065976779	0.115886186565541	1.18906325055118	0.574260475167698	1.09859497235328	0.819085564595159	0.318531706241037	0.869210914128203	0.88784506350083	0.792234396077052	0.42341707954936	0.877398541061998	0.596880169991516	0.845936733113266	p.Arg11Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.365	-2.971	0.606	5.948	5.948	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.245	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
R11T	11	R	T	missense	wt-like	1.29395467005388	0.152468226980909	3	0.0880275718902928	1.12142379950239	1.46648554060536	NA	1.22746650833486	NA	NA	1.46837613402457	NA	1.1860213678022	NA	0.926370544791838	NA	0.874064926039401	NA	NA	0.928623236401809	NA	0.926370544791838	NA	p.Arg11Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.365	-3.395	1.03	5.187	5.187	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.245	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.714285714285714
R11V	11	R	V	missense	wt-like	1.13399860592158	0.0683020404624835	8	0.02414841798995	1.08666857637766	1.18132863546551	1.14244850181507	1.04858939209721	1.15973709011551	1.16848140012845	1.2066983659182	1.06455628639849	1.22210277884579	1.05937503205396	0.828557642835197	0.850662886344261	0.791605585876822	0.862847691036732	0.808136599647507	0.830876691366769	0.816032458718378	0.945803754385996	0.826238594303625	p.Arg11Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.365	-3.968	1.603	4.346	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R11W	11	R	W	missense	wt-like	1.08642654113395	0.174516747164086	4	0.0872583735820432	0.9154032715636	1.25744981070429	NA	1.22003446489287	1.05017577277278	1.22141053688252	0.854085389987613	NA	NA	NA	0.820230913657542	NA	0.870638879090659	0.809113073169344	0.83134875414574	0.699162406346847	NA	NA	NA	p.Arg11Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.365	-5.643	3.278	2.49	NA	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R11X	11	R	X	nonsense	possibly_low	0.525551013976816	0.375488999377912	4	0.187744499688956	0.157578556290971	0.893523471662662	0.903973447801183	NA	NA	NA	0.308522245359474	NA	0.776250457414453	0.113457905332156	0.600522287165923	0.737202055310681	NA	NA	NA	0.495373934472626	NA	0.70567063985922	0.351153555357096	p.Arg11Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R11Y	11	R	Y	missense	wt-like	0.993678518139416	0.030468447769749	3	0.0175909665216547	0.959200857303723	1.02815617897511	NA	NA	NA	NA	0.960365445702704	1.00053680384466	NA	1.02013330487088	0.78447900414072	NA	NA	NA	NA	0.738862027478051	0.78447900414072	NA	0.806529513073952	p.Arg11Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.365	-3.763	1.398	28.747	28.747	43.18	0.003042402	0	0.086956917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N12A	12	N	A	missense	possibly_wt-like	0.858563545485014	0.302730353581725	6	0.12358914932126	0.616333263935402	1.10079382703463	0.9886555485742	0.775349416492549	0.871299806605175	1.20320372194002	0.314581174287409	NA	NA	0.998291605010737	0.749437362768057	0.777491810426184	0.665646555631358	0.72138291510993	0.823364127392242	0.497637173622074	NA	NA	0.795559561758367	p.Asn12Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.733	-3.193	1.46	9.895	8.985	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.02	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N12C	12	N	C	missense	wt-like	0.871485426686977	0.076793200173564	2	0.054300992591743	0.765057436882384	0.977913416491569	0.92578641927872	NA	NA	NA	NA	NA	NA	0.817184434095234	0.726089496004881	0.747580154946247	NA	NA	NA	NA	NA	NA	0.704598837063514	p.Asn12Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.733	-5.484	3.751	1.651	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N12D	12	N	D	missense	possibly_wt-like	0.996460642374453	0.437770510010564	7	0.165461700115124	0.672161669328044	1.32075961542086	NA	1.03975007335676	1.01164431694495	1.27381973512634	1.29138988304127	0.0441114382455281	1.2694238668303	1.04508518307602	0.819061545420126	NA	0.787530808699309	0.790215225781244	0.854332888808966	0.862512176690807	0.313083061429408	0.971290579718735	0.819061545420126	p.Asn12Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.733	-2.539	0.806	10.533	10.533	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.47	Neutral	DAMAGING	effect	DAMAGING	pathogenic	N	D	T	D	D	D	0.571428571428571
N12E	12	N	E	missense	possibly_wt-like	0.779020588431753	0.402075837583691	6	0.164146773330368	0.457298824525772	1.10074235233773	0.98801675939833	1.06427938700903	1.07388764613457	0.99354539551681	NA	0.124468726643675	NA	0.429925615888101	0.75430301737418	0.777187889535803	0.798838409475479	0.820742619846204	0.731418145212556	NA	0.352688974321983	NA	0.510098848076179	p.Asn12Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.733	-2.701	0.968	9.067	9.067	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.675	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N12F	12	N	F	missense	low	0.369353294158617	0.290108773853515	7	0.109650809824897	0.154441656026169	0.584264932291066	0.573368436768875	0.362774406571626	0.569302339942587	0.503476343621434	-0.253793671763056	0.335067759931069	NA	0.495277444037786	0.516497607206202	0.579907954044195	0.475456419513275	0.573267513966396	0.516497607206202	0.28532766835423	0.45648748636627	NA	0.542921676783509	p.Asn12Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.733	-4.692	2.959	1.89	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N12G	12	N	G	missense	wt-like	1.12483478032294	0.10119302920304	8	0.0357771385791391	1.05471287723793	1.19495668340795	1.11780212126521	1.12841883489696	1.13901856395019	1.27931336345456	0.939845530111526	1.22520935457037	1.08664519022744	1.08242528410727	0.845811478033381	0.838936717203759	0.828405615513192	0.852686238863003	0.856742127979122	0.731197062785165	0.89521396858236	0.87284719213959	0.837815538609971	p.Asn12Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.733	-2.922	1.189	13.411	13.411	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.675	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N12H	12	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn12His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.733	-3.387	1.654	18.097	18.097	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.82	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
N12I	12	N	I	missense	low	0.298716907917441	0.272271541633364	7	0.102908969748864	0.0970190335235451	0.500414782311336	0.485898450580292	0.190710192134008	0.487929509318935	0.676684716871585	-0.0297773258585803	NA	-0.0348575605181706	0.314430372894017	0.452091586693627	0.538291788510695	0.396137712422378	0.533358008819874	0.592458406244937	0.369006247554877	NA	0.268813220482079	0.452091586693627	p.Asn12Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.733	-4.386	2.653	3.627	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N12K	12	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn12Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.733	-2.169	0.436	24.063	24.063	90.57	0.003537981	0	0.101121384	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 17, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.03	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
N12L	12	N	L	missense	low	0.303689199600512	0.0745707984679491	7	0.0281851125448157	0.248447394112465	0.358931005088558	0.219229141925676	0.328636344506103	0.291625710020258	0.430140755390678	0.273276197594627	0.227234726030459	NA	0.355681521735779	0.459719347429598	0.41141679315231	0.459719347429598	0.437080327088165	0.484336171962315	0.482208202358336	0.403339528878592	NA	0.472809896047002	p.Asn12Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.733	-3.251	1.518	11.834	11.834	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N12M	12	N	M	missense	low	0.441627364898512	0.12946566143244	3	0.0747470344788321	0.295125869368827	0.588128860428197	NA	NA	NA	NA	0.567028317791398	NA	0.449406021891026	0.308447755013112	0.529634386384035	NA	NA	NA	NA	0.591935731195563	NA	0.529634386384035	0.449086828487375	p.Asn12Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.733	-5.017	3.284	1.571	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N12N	12	N	N	synonymous	wt-like	1.27847055661566	0.26531395709961	3	0.153179084551225	0.978245067710444	1.57869604552088	NA	1.45674894343886	0.97356735224384	1.40509537416429	NA	NA	NA	NA	0.911904022631933	NA	0.97976026990008	0.771540284685348	0.911904022631933	NA	NA	NA	NA	p.Asn12=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	187	187	0	11.6	11.6	0	132	132	0	5.47	5.47	0	NA	NA	NA	NA	NA	NA	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
N12P	12	N	P	missense	wt-like	1.17500059348107	0.153748328953547	7	0.0581114061289767	1.0611043303773	1.28889685658485	1.21770412161519	1.22117623968126	1.3360462863108	1.31990656179691	0.892175749487993	NA	1.16736851897248	1.07062667650288	0.874544337674664	0.886467743157381	0.871165218052542	0.949318970442977	0.874544337674664	0.713390596487904	NA	0.916324243653609	0.831889710865765	p.Asn12Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.733	-3.186	1.453	14.363	14.363	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.565	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N12Q	12	N	Q	missense	wt-like	0.943814519970801	0.201828634498541	6	0.0823961950006851	0.782320945306319	1.10530809463528	NA	1.11728107006942	1.03777626481202	1.17896526759774	0.900968562576805	0.745137960113231	0.682757994655594	NA	0.759853374373011	NA	0.823271293371367	0.80303170395825	0.812734315883971	0.716675044787772	0.65859988901213	0.655316217132454	NA	p.Asn12Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.733	-2.427	0.694	8.918	8.918	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N12R	12	N	R	missense	wt-like	0.933267427472036	0.117597527672956	8	0.0415770046341601	0.851777995804027	1.01475685914004	0.936550627356788	0.784299414709339	0.788995699025448	0.957789580265039	0.868950273406025	1.13552219712456	0.994283410334179	0.999748217554911	0.734219444860353	0.752701512393911	0.669772354184776	0.681016662887185	0.715737377326795	0.704715002606793	0.851009618035066	0.823101747733685	0.79629114257843	p.Asn12Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.733	-2.631	0.898	15.537	15.537	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.72	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N12S	12	N	S	missense	wt-like	1.0771928446977	0.150506464174401	8	0.0532120707150647	0.972899102553375	1.18148658684203	0.767524800635974	1.26710442544084	1.15607743626688	1.08669518934452	0.967070290211188	1.14063804460372	1.13960071075977	1.09283186031871	0.848286650417746	0.672282992959318	0.892337338736596	0.861052804795376	0.772269130858772	0.741366540530283	0.853531079543665	0.901368685615258	0.843042221291828	p.Asn12Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.733	-2.719	0.986	19.919	19.919	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.565	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N12T	12	N	T	missense	wt-like	1.02772901206215	0.162381548370667	5	0.0726192360896964	0.885397924741533	1.17006009938277	NA	0.871595053512957	1.05082824405131	1.14166881983811	1.22084538728226	NA	NA	0.853707555626122	0.796377901237455	NA	0.710014174526142	0.809433079314501	0.796377901237455	0.836161138994399	NA	NA	0.722942503886722	p.Asn12Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.733	-3.183	1.45	7.439	6.712	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.365	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
N12V	12	N	V	missense	low	0.520032604501607	0.108423855719475	6	0.0442638537429763	0.433277045348425	0.606788163654789	NA	0.501069836226277	0.505257898404593	0.641322588790952	0.619224023238376	NA	0.336621930055057	0.516699350294388	0.547768773746309	NA	0.539208285132979	0.541856759915231	0.576950290474831	0.611432801619348	NA	0.468889619698288	0.553680787577387	p.Asn12Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.733	-4.042	2.309	3.733	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N12W	12	N	W	missense	low	0.435518562622772	0.305180071851691	7	0.115347225030342	0.209442155846664	0.66159496939888	NA	0.316536538415278	0.643448766584968	0.791224519073729	-0.124327536117665	0.299198140247042	0.486272466578994	0.636277043577059	0.549490409912252	NA	0.454141540456127	0.609632811486477	0.642690013030182	0.333688167413635	0.438808330423918	0.549490409912252	0.61373845168504	p.Asn12Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.733	-5.802	4.069	0.455	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N12X	12	N	X	nonsense	low	0.254067175619375	0.160497166461727	3	0.0926630822608505	0.0724508716916353	0.435683479547114	NA	NA	NA	0.209685773877294	0.120430860774912	NA	NA	0.432084892205917	0.425114687280771	NA	NA	NA	0.387655300052956	0.425114687280771	NA	NA	0.511183340411254	p.Asn12Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N12Y	12	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn12Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.733	-4.572	2.839	2.967	NA	90.57	0.003537981	0	0.101121384	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.365	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K13A	13	K	A	missense	possibly_wt-like	0.846432149406378	0.398369253109464	7	0.150569424814598	0.551321499596855	1.1415427992159	NA	1.18181850396894	0.917517964880354	0.865643499902347	0.179344951744312	1.18533905130168	0.430484786704315	1.1648762873427	0.74405072464057	NA	0.853021964262494	0.74405072464057	0.675326571767593	0.447121328837719	0.875562984959862	0.519443534127189	0.87922639477983	p.Lys13Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.115	-3.376	2.261	6.345	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K13C	13	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.115	-5.353	4.238	1.588	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K13D	13	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.115	-3.822	2.707	3.236	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K13E	13	K	E	missense	wt-like	1.16041273250948	0.0902249499586617	3	0.0520913991462539	1.05831546627852	1.26250999874044	NA	1.1842735828533	1.23630904848567	1.06065556618947	NA	NA	NA	NA	0.85415371431029	NA	0.85415371431029	0.90040259656517	0.760849413991685	NA	NA	NA	NA	p.Lys13Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.115	-2.927	1.812	7.887	7.887	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	1	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K13F	13	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.115	-4.525	3.41	5.903	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K13G	13	K	G	missense	wt-like	1.09758582344285	0.0878329701249197	8	0.0310536443935431	1.03672179884279	1.15844984804291	1.14469707902699	1.02956054438565	1.0226876922625	1.1223218726501	1.23855470257248	0.96152991732976	1.14411522946135	1.11721954985398	0.819203857277389	0.851732706582535	0.78283360732891	0.795631476398222	0.787893267730512	0.842776238156556	0.765253575056239	0.903800175559996	0.855290890974803	p.Lys13Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.115	-3.657	2.542	3.73	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K13H	13	K	H	missense	wt-like	1.09970625683376	0.0444642468874416	3	0.0256714449097784	1.0493911493795	1.15002136428803	NA	NA	NA	NA	1.04888949747763	1.11876546509558	1.13146380792809	NA	0.842750682444609	NA	NA	NA	NA	0.771929109470225	0.842750682444609	0.896986203511537	NA	p.Lys13His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.115	-4.678	3.563	1.269	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K13I	13	K	I	missense	wt-like	1.08750792041841	0.173463674531679	6	0.0708162485851381	0.948710623671304	1.22630521716552	NA	1.21714219823756	1.13367268371804	1.10595891851378	1.193009230938	1.13143059289781	0.743833898205269	NA	0.837378129838872	NA	0.869305592838133	0.850064338739796	0.780717268975335	0.825763281624262	0.848992978053482	0.688211295248985	NA	p.Lys13Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.115	-4.278	3.163	4.6	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K13L	13	K	L	missense	wt-like	0.926085234347154	0.134829935892382	8	0.0476695809882253	0.832654572452117	1.01951589624219	1.11843742592096	0.932328208822888	0.726832155192412	0.962009487353143	0.804921015310774	1.09647529284368	0.852693557071925	0.91498473226145	0.742426762639214	0.839238980241285	0.738011137011801	0.650528399746816	0.717588024084032	0.680797652633738	0.831764465286623	0.746842388266628	0.753718846788155	p.Lys13Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.115	-3.65	2.535	5.672	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K13M	13	K	M	missense	possibly_low	0.694647932561349	0.605175234217525	5	0.270642592401949	0.164198198770976	1.22509766635172	-0.101033973048852	0.34470583800119	NA	NA	1.40480071998297	NA	0.677602234387011	1.14716484348443	0.65253935871648	0.259043123190602	0.467127113488344	NA	NA	0.904875414350636	NA	0.65253935871648	0.870330856515957	p.Lys13Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.115	-4.786	3.671	1.723	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K13N	13	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.115	-3.769	2.654	3.816	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K13P	13	K	P	missense	wt-like	1.1840859183244	0.0890974645178932	8	0.0315007106735651	1.1223456599168	1.24582617673201	1.21709675685333	1.14981734708381	1.13037211776588	1.2930905426953	1.00825928813084	1.24906108618035	1.18260918446108	1.24238102342464	0.874481452216968	0.886178773265306	0.838269969503806	0.848445568041463	0.862784131168629	0.756752189335055	0.906969835701735	0.924532765388984	0.918152997882619	p.Lys13Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.115	-4.046	2.931	2.306	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K13Q	13	K	Q	missense	wt-like	1.00036493757133	0.245823716415276	5	0.109935708077238	0.784894909125033	1.21583496601762	0.599325401377328	0.931447235936069	1.18753884929314	1.16539513937056	NA	NA	NA	1.11811806187954	0.806783115235573	0.592257668305767	0.737605023337362	0.876483132282639	0.806783115235573	NA	NA	NA	0.855742166893796	p.Lys13Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.115	-3.777	2.662	2.355	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	1	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K13R	13	K	R	missense	possibly_low	0.678324204608399	0.231826318652763	6	0.0946426982745211	0.492827924590646	0.863820484626151	NA	0.708391980401559	0.689551649543302	0.700575266837307	0.793037948131838	NA	0.244125783515727	0.93426259922066	0.633512194205828	NA	0.634780304457532	0.632244083954125	0.602935643752676	0.67635887753425	NA	0.419071806304587	0.76340111801086	p.Lys13Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.115	-1.512	0.397	15.537	15.537	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.26	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
K13S	13	K	S	missense	wt-like	1.0464369104736	0.0817452494948956	6	0.0333723583598331	0.981028290009166	1.11184553093804	NA	1.15855552231377	1.11885519684281	1.02524310102687	0.932000916866052	NA	1.0426680381803	1.00129868761182	0.81968399218854	NA	0.842298121225183	0.842797065816227	0.745319222816705	0.728266802994928	NA	0.849161388608957	0.797069863151897	p.Lys13Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.115	-3.537	2.422	8.022	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K13T	13	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.115	-2.891	1.776	21.357	21.357	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	1	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.857142857142857
K13V	13	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.115	-3.875	2.76	6.212	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K13W	13	K	W	missense	possibly_low	0.560495093317937	0.282939741882217	7	0.106941170433879	0.350894250802975	0.7700959358329	0.780621797859999	0.901232228149956	0.564571309747729	0.723670525449266	0.189310221429826	0.172684322642258	NA	0.591375247946527	0.591186612075338	0.678514236706079	0.72367641325322	0.570947168557948	0.613064105011515	0.450843734027699	0.376453124820964	NA	0.591186612075338	p.Lys13Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.115	-3.686	2.571	44.972	44.972	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K13X	13	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	2	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K13Y	13	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys13Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.115	-4.409	3.294	6.169	NA	90.57	0.003014117	0	0.086148469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R14A	14	R	A	missense	wt-like	1.08755153062324	0.198892957439518	8	0.0703192794678651	0.949728275447417	1.22537478579906	1.231292975432	1.18935680945417	1.1847225314228	1.19860406121057	1.00720233460502	1.22959606468356	1.00957279128575	0.650064676892046	0.84391675176019	0.892933000721634	0.85649699622483	0.875101862248414	0.821346939090317	0.756357377211124	0.897376058196024	0.83133650729555	0.620663263727647	p.Arg14Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.782	-3.182	1.4	8.194	8.194	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R14C	14	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg14Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.782	-3.512	1.73	13.671	13.671	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R14D	14	R	D	missense	wt-like	1.14287292580154	0.137503321258386	5	0.0614933546931484	1.02234816531442	1.26339768628866	1.23145883987848	0.924250718483753	1.10485242897902	1.27390355057377	NA	NA	NA	1.17989909109267	0.854369646202613	0.893011915130584	0.73428754990606	0.835929373837926	0.854369646202613	NA	NA	NA	0.88677156877343	p.Arg14Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.782	-4.038	2.256	5.3	NA	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R14E	14	R	E	missense	wt-like	0.998909639665705	0.166395225803257	8	0.058829596261275	0.883605749768574	1.11421352956284	0.744033372910216	1.04662061293379	0.997863250399579	1.21274724572026	0.833336878668021	1.21978406054961	1.0057942013829	0.931097494761262	0.787077139788319	0.661106323252916	0.790698011816172	0.783456267760466	0.827549454454608	0.691412052502166	0.892539989324396	0.829301383739443	0.761811450446034	p.Arg14Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.782	-3.356	1.574	17.396	17.396	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R14F	14	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg14Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.782	-3.481	1.699	13.964	13.964	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R14G	14	R	G	missense	wt-like	1.04631547009443	0.0721665017456275	8	0.025514711379422	0.996307554714829	1.09632338547403	1.11721792963188	1.07255324293385	1.06685021234203	1.03117205703976	0.906699805552881	1.04248279301865	0.99697008126066	1.13657763897574	0.811222064886529	0.838658772542107	0.802652517811472	0.817291093114136	0.747919375613902	0.718815880838621	0.805153036658923	0.824548770943552	0.86501345362277	p.Arg14Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-1.142	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.782	-3.845	2.063	3.955	NA	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R14H	14	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg14His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.782	-3.417	1.635	30.747	30.747	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.155	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R14I	14	R	I	missense	possibly_low	0.664439691750284	0.348515089504688	3	0.201215280742178	0.2700649883565	1.05881439514407	NA	NA	NA	NA	0.262047639614685	NA	0.860814421723016	0.870457013913151	0.73135488676661	NA	NA	NA	NA	0.478013911203197	NA	0.751216232312244	0.73135488676661	p.Arg14Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.782	-2.551	0.769	13.071	13.071	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.11	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R14K	14	R	K	missense	possibly_low	0.609680597685592	0.526533616742199	4	0.263266808371099	0.0936871349534298	1.12567406041775	NA	0.607070811851323	1.06148631362155	NA	-0.128088508864068	NA	NA	0.898253774133561	0.666694353261852	NA	0.588072950946455	0.814660355778964	NA	0.332283301824203	NA	NA	0.745315755577249	p.Arg14Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.782	-2.186	0.404	25.095	25.095	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
R14L	14	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg14Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.782	-2.942	1.16	10.343	10.343	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R14M	14	R	M	missense	wt-like	1.15249330027793	0.154291697742133	5	0.0690013449030518	1.01725314938313	1.28773345117274	0.96244026786137	1.13077696623801	NA	NA	1.37492924912624	NA	1.07971626087758	1.21460375728646	0.869115316571967	0.765019195427707	0.829492674375108	NA	NA	0.893717290018983	NA	0.869115316571967	0.904201919936899	p.Arg14Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.782	-3.921	2.139	3.095	3.095	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	2	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R14N	14	R	N	missense	wt-like	1.09555841013013	0.108149508598695	5	0.0483659305919762	1.00076292809109	1.19035389216916	NA	1.04675122189454	1.07370420946105	1.26947116228893	NA	0.979320617564622	NA	1.10854483944149	0.820652652877996	NA	0.790758220348988	0.820652652877996	0.852425815489071	NA	0.774022125337686	NA	0.85093403452539	p.Arg14Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.782	-2.522	0.74	10.846	10.846	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R14P	14	R	P	missense	possibly_wt-like	0.792625608121405	0.381693588782281	7	0.144266616135095	0.509868236325153	1.07538297991766	1.25113179762148	0.662103807207478	1.03277977716851	0.572111524025579	0.736112580787935	0.14957166267482	NA	1.14456810736404	0.655095099480108	0.902371846481218	0.613442235624601	0.800581164290465	0.54659767135343	0.655095099480108	0.365061525930138	NA	0.869026650845041	p.Arg14Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.782	-4.341	2.559	2.456	NA	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R14Q	14	R	Q	missense	wt-like	1.24720707903683	0.137766913761537	3	0.0795397647456475	1.09131200479657	1.40310215327709	NA	1.12309808471368	1.22307897544019	1.39544417695663	NA	NA	NA	NA	0.893913874663146	NA	0.825952839224579	0.893913874663146	0.907671475222027	NA	NA	NA	NA	p.Arg14Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.782	-3.227	1.445	8.44	8.44	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.81	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R14R	14	R	R	synonymous	wt-like	1.15521533457561	0.126069273103981	3	0.0727861287631238	1.0125571436258	1.29787352552543	NA	1.10506464510483	1.06193890332024	1.29864245530178	NA	NA	NA	NA	0.817639727059733	NA	0.817639727059733	0.81488232951111	0.865218930998844	NA	NA	NA	NA	p.Arg14=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R14S	14	R	S	missense	possibly_low	0.582948190164705	0.436844525883251	5	0.195362811094723	0.200044116500545	0.965852263828864	1.00423893937524	NA	NA	NA	0.286357272358096	0.198792165676443	0.314778132611269	1.11057444080247	0.487094478608424	0.784906021853533	NA	NA	NA	0.487094478608424	0.38932096764689	0.457124694719476	0.851953397865356	p.Arg14Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.782	-3.345	1.563	4.83	4.093	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R14T	14	R	T	missense	wt-like	0.962285443245407	0.238066731038653	8	0.0841692999461729	0.79731664674696	1.12725423974386	0.398414866745516	0.96181432730058	0.971880667670384	1.1509939169185	1.09202852103421	1.0991594610869	0.976168856117864	1.04782292908931	0.79425530177459	0.496669153536425	0.751603741391647	0.770713046083114	0.800467436933959	0.78804316661522	0.833087418509026	0.813345368517663	0.820436573035763	p.Arg14Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.782	-3.07	1.288	6.529	6.529	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.81	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R14V	14	R	V	missense	wt-like	0.867650334177895	0.124059325650682	8	0.0438615952185137	0.781683187245134	0.953617481110656	0.71887479227787	0.965874988897418	0.901745172396806	0.804830836273882	0.877885785806741	0.68696682747359	0.933725277579787	1.05129899271707	0.722183837113376	0.64913646134021	0.753475638048646	0.736314919729119	0.648657084408454	0.708052754497633	0.629928926388643	0.790485537546524	0.822182419238695	p.Arg14Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.782	-2.782	1	8.486	7.549	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.155	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R14W	14	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg14Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.782	-5.624	3.842	1.071	NA	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R14X	14	R	X	nonsense	possibly_low	0.37155465755546	0.27511325972063	2	0.194534451542793	-0.00972586122066676	0.752835176331587	NA	NA	NA	NA	0.177020206012667	0.566089109098253	NA	NA	0.508302274270636	NA	NA	NA	NA	0.446252948367351	0.570351600173921	NA	NA	p.Arg14Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R14Y	14	R	Y	missense	wt-like	1.1073722558994	0.226517383321701	7	0.0856155234146158	0.93956891348921	1.2751755983096	NA	1.41151371691198	0.941511403477889	0.959452217677556	1.25043952949959	1.30555961042521	1.10162365998372	0.781505653319876	0.847215670588556	NA	0.958907591760104	0.75581836568061	0.716466529526522	0.847215670588556	0.934816415326395	0.880914496985895	0.686679238744189	p.Arg14Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	-0.697	21.7	100.1	31.8	0	360	360	360	-19.4	90.188679245283	-0.4	0	0	90.39	0	0	0	0	5	19.4843151755457	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.782	-3.134	1.352	12.365	12.365	43.18	0.003618079	0	0.103410715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15A	15	R	A	missense	wt-like	0.946110631684811	0.139354332427911	8	0.0492691967237503	0.849544780559042	1.04267648281058	0.93408386680041	1.00915424473292	1.08873502254236	1.14391991724176	0.847157529163929	0.704856955550652	0.881501416351979	0.959476101094475	0.767892378778071	0.751527885643537	0.773426646618026	0.82802455216462	0.797365123473232	0.69657458826471	0.638746481938134	0.762358110938117	0.776064550336283	p.Arg15Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.883	-2.788	1.905	6.109	6.109	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R15C	15	R	C	missense	wt-like	0.955462373394813	0.327644537734499	7	0.123837995039172	0.712744363200386	1.19818038358924	1.01012011002446	1.05869949299192	1.10762467442652	1.25774022082321	0.286131141103881	0.801880228511999	NA	1.1660407458817	0.796266172240743	0.787704144751837	0.796266172240743	0.837289028443852	0.847281193029477	0.487010010030967	0.686566603473598	NA	0.879811241818459	p.Arg15Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.883	-3.511	2.628	9.954	9.954	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15D	15	R	D	missense	wt-like	1.07312997984404	0.0941576727645704	8	0.0332897644562858	1.0078832404559	1.13837671923219	0.962793181776516	1.07077932192904	1.18583007369473	1.20323699006339	1.10533845817462	1.01545221414429	0.948656231277478	1.09295336769229	0.800181010320093	0.765187103581712	0.801834770082566	0.875645059082819	0.82337871717902	0.793014931620414	0.791830402537307	0.798527250557619	0.843103248134117	p.Arg15Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.883	-3.888	3.005	3.808	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R15E	15	R	E	missense	wt-like	0.913789738698054	0.234169456262773	8	0.0827914052350868	0.751521566207823	1.07605791118829	0.941318504296039	1.10039230202654	0.985281994428641	1.07482051704398	0.368193406547904	0.984985278479909	0.843705103143879	1.01162080361755	0.771937778510447	0.754969956286418	0.815485855534115	0.777285759790255	0.767061475020045	0.517663370394547	0.776814082000848	0.742001266368702	0.802254125859546	p.Arg15Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.883	-3.447	2.564	6.436	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R15F	15	R	F	missense	wt-like	1.1827582463852	0.121775073894946	7	0.0460266516303628	1.09254766686072	1.27296882590968	1.26340138391719	1.22219944546348	1.10454047737712	0.96199440857228	1.34013839352019	1.17047996311382	1.21655365273232	NA	0.871636898698041	0.908209427536842	0.871636898698041	0.835776376406646	0.717581411261445	0.880721589394838	0.86823934619401	0.942815031724979	NA	p.Arg15Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.883	-4.483	3.6	1.478	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15G	15	R	G	missense	wt-like	1.01212332220966	0.137140632790938	8	0.0484865357113431	0.917091458480311	1.10715518593901	0.954492609782795	1.04141428564243	1.05628214184677	1.10053293854755	0.701972433435795	1.14087934603711	1.01941460731573	1.0819982150691	0.800202969736326	0.761237886333996	0.788297982555045	0.812107956917606	0.77833769709859	0.642342463003544	0.853650010430237	0.836637244383321	0.837601044015356	p.Arg15Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.883	-3.581	2.698	3.955	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R15H	15	R	H	missense	wt-like	1.22510345780072	0.0883493847943184	4	0.0441746923971592	1.13852265167415	1.31168426392729	NA	1.24369690225684	1.14228377062755	1.34132817019646	NA	NA	NA	1.17310498812203	0.882453054122332	NA	0.881546864487065	0.854287667517945	0.883938817053411	NA	NA	NA	0.883359243757599	p.Arg15His	0	0	NA	NA	NA	NA	NA	NA	NA	-3.541	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.883	-3.347	2.464	7.379	7.379	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15I	15	R	I	missense	wt-like	1.09873641815531	0.165996032050295	8	0.0586884599564115	0.983709150332625	1.213763685978	1.27841050451315	1.10337080246959	1.14791289833788	1.06484640082703	0.77215025007237	1.23341762719063	0.968036113355152	1.22174674847669	0.836953690587895	0.915350414685128	0.816858894111515	0.857048487064275	0.762687310980931	0.668556532177123	0.899259601988826	0.808965126999607	0.907789473383115	p.Arg15Ile	1	0	NA	NA	NA	NA	NA	NA	NA	0.876	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.883	-4.198	3.315	2.438	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	not provided	Uncertain significance	no assertion criteria provided	0	0	1	0	0	7	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R15K	15	R	K	missense	wt-like	1.20518009112705	0.135868914547364	3	0.0784439543884231	1.05143276572084	1.35892741653327	NA	NA	NA	NA	1.34988530501848	NA	1.08033307738636	1.18532189097633	0.884362429541919	NA	NA	NA	NA	0.884362429541919	NA	0.869447529868216	0.88949515947831	p.Arg15Lys	1	0	NA	NA	NA	NA	NA	NA	NA	-1.376	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.883	-2.521	1.638	25.095	25.095	90.57	0.001125047	0	0.032155704	0	NA	NA	PTEN hamartoma tumor syndrome|not provided	Conflicting interpretations of pathogenicity(Last reviewed: Mar 13, 2017)	criteria provided, conflicting interpretations	0	0	1	0	0	4	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	3.44	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R15L	15	R	L	missense	wt-like	1.11928812140498	0.230944794132099	8	0.0816513150052691	0.959254484704315	1.27932175810564	0.604541657572791	1.20971344541353	1.23162221193154	1.38297379505307	1.0605548191053	1.08320333936534	1.15169788512833	1.22999781766993	0.881992494422762	0.594739440519924	0.865881062808887	0.898103926036636	0.902202570018786	0.776286548369517	0.825223081874417	0.907884143802777	0.911933556853309	p.Arg15Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.883	-3.583	2.7	3.837	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R15M	15	R	M	missense	wt-like	1.08697403681407	0.169854024401118	7	0.0641987868212648	0.961146726793228	1.21280134683492	1.03113098908544	0.778656625017879	1.10984795096883	1.29064551441001	1.25427878141767	NA	1.11949671088596	1.02476168591271	0.83837943989848	0.797700627649649	0.667171123102675	0.83837943989848	0.86171186024582	0.848649776409724	NA	0.890540804112595	0.808854108459106	p.Arg15Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.883	-4.717	3.834	1.415	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15N	15	R	N	missense	possibly_wt-like	0.824218695648936	0.484368415303272	7	0.183074052832416	0.465400145593618	1.18303724570425	NA	1.16920690914725	1.06564319697665	1.23183182712531	0.426583875257069	-0.0494625270513107	0.734447296927845	1.19128029115974	0.816699109456111	NA	0.847208231297273	0.816699109456111	0.835919027043076	0.539474419229913	0.266963009441131	0.683155733819289	0.892487754393051	p.Arg15Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.883	-3.715	2.832	3.8	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R15P	15	R	P	missense	wt-like	0.995975625540364	0.0868835992897572	7	0.032838913818698	0.931612537164301	1.06033871391643	1.04226596696011	1.04478682083609	0.977635609040282	1.14546595981287	0.932105866445923	NA	0.894533705847483	0.935035449839792	0.773535571248573	0.802998388660436	0.789852664521042	0.773535571248573	0.798043142825565	0.728306005633002	NA	0.769377215954602	0.763789280732644	p.Arg15Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.883	-4.088	3.205	2.456	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R15Q	15	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg15Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.883	-3.057	2.174	5.68	5.68	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R15R	15	R	R	synonymous	wt-like	1.03242544166684	0.13130933172226	8	0.0464248594469419	0.941434389163495	1.12341649417018	1.12684960654466	0.926272160046652	0.93759531030078	1.0287527213868	1.27010179626159	1.09810233926033	1.01349494803892	0.858234651494954	0.793232050084943	0.843241298254449	0.735219400446587	0.753897708139164	0.746858372234602	0.854560271000928	0.832566392030722	0.833448955008679	0.72521622899054	p.Arg15=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R15S	15	R	S	missense	wt-like	1.0251315149842	0.30592646854015	8	0.108161340224596	0.813139183624409	1.23712384634399	0.284455026356957	1.04440485670822	1.09596509281865	1.14124688517559	1.25103742510197	1.16524451270287	1.14685499761272	1.07184332339664	0.832035663669322	0.442449737386563	0.789676585486386	0.831570557934477	0.796192861140919	0.847439007213012	0.865658935666686	0.90527579658437	0.832500769404167	p.Arg15Ser	1	0	NA	NA	NA	NA	NA	NA	NA	1.451	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.883	-3.571	2.688	4.83	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Mar 13, 2017)	criteria provided, single submitter	0	1	0	0	0	3	1	0	1	0	0	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R15T	15	R	T	missense	wt-like	0.966155196017828	0.209530717488856	8	0.0740802956016265	0.820960484674559	1.1113499073611	1.18327097959578	1.04884318687408	0.842295902679618	1.04590766160951	0.773757727668918	1.13338288843685	0.58623104670146	1.11555217457641	0.773052139353142	0.870085262713989	0.791722580997706	0.707157879012318	0.754381697708578	0.669156985866486	0.849955211207448	0.603327440728696	0.85445345498141	p.Arg15Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.883	-3.658	2.775	3.655	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 17, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R15V	15	R	V	missense	wt-like	0.988403512034052	0.141901713818041	8	0.0501698320513648	0.890072448102953	1.08673457596515	1.01393030111284	0.75060372687121	0.9808246325377	0.98001270682063	0.840899622962608	1.210735392438	1.08338076473316	1.04684094879626	0.782308289939692	0.789516944204058	0.654239209174964	0.775099635675326	0.725483363728178	0.694237023576816	0.888080147931458	0.871088994136791	0.819943375341603	p.Arg15Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.883	-3.898	3.015	3.015	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R15W	15	R	W	missense	wt-like	1.04324698478536	0.160253138973519	8	0.0566580406373028	0.932199265701636	1.15429470386908	0.832386277582855	1.06069067396879	1.1330523976809	0.984936508830147	1.29814532481384	1.01877923137875	0.842233484056719	1.17575197997086	0.795327135815829	0.703142560669197	0.797184073160384	0.849760117925529	0.727642704688048	0.865035589735148	0.793470198471275	0.741208662051509	0.88468869027048	p.Arg15Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.883	-5.527	4.644	0.424	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R15X	15	R	X	nonsense	possibly_low	0.570876878614779	0.462506987335357	6	0.188817686907251	0.200801012632407	0.94095274459715	0.0880296562566932	0.36756212903062	NA	0.472904969102789	1.12707495650023	1.15926710120711	NA	0.210422459591231	0.49037698139293	0.348995158584554	0.477663478991613	NA	0.503090483794247	0.801134335985041	0.862712832783632	NA	0.399853814328254	p.Arg15Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R15Y	15	R	Y	missense	wt-like	1.25365375351507	0.0965336836353858	8	0.0341298111557491	1.18676055285065	1.32054695417949	1.13898208280274	1.21871949995201	1.28013646100532	1.40412204244102	1.37971990144225	1.24500005532273	1.15809849139775	1.20445149375675	0.902035614902067	0.849013645573663	0.870032702383203	0.921897858953198	0.911477166504589	0.895506779877989	0.904968264498831	0.911331468049967	0.899102965305303	p.Arg15Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.8	101.4	30.1	0.395	360	153.9	-104.2	-173.9	44.1509433962264	-1.4	0	0	88.68	0	0	0	0	6	17.8806459016446	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.883	-4.326	3.443	1.556	NA	90.57	0.001125047	0	0.032155704	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y16A	16	Y	A	missense	wt-like	0.950068707119811	0.130596977059975	5	0.0584047436724171	0.83559751299558	1.06453990124404	0.868633163828149	NA	0.763686825520172	NA	1.08180663615709	1.00718527725803	NA	1.02903163283561	0.784224905944034	0.720387978026482	NA	0.668603863557603	NA	0.784224905944034	0.787755855116249	NA	0.810998681004479	p.Tyr16Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.511	-3.598	2.087	9.489	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16C	16	Y	C	missense	possibly_wt-like	0.819492613439528	0.441730295261964	7	0.166958358260898	0.492260244330232	1.14672498254882	0.781785571602668	1.36378231636766	0.950314864045689	0.814913473500286	-0.0835588017133489	0.910262547117736	NA	0.998948323156012	0.739985288391458	0.679067932926106	0.936904219407591	0.760136044593154	0.65307884050352	0.348916831897861	0.739985288391458	NA	0.795889397170805	p.Tyr16Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.511	-5.209	3.698	1.583	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y16D	16	Y	D	missense	wt-like	1.16691212619323	0.209435147444941	2	0.148093012977122	0.876655154396052	1.45716909799042	NA	NA	NA	1.31500513917036	NA	NA	NA	1.01881911321611	0.839132137048274	NA	NA	NA	0.872394811227685	NA	NA	NA	0.805869462868863	p.Tyr16Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.511	-4.258	2.747	4.255	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Dec 23, 2016)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y16E	16	Y	E	missense	wt-like	1.01435617102628	0.199441055538438	4	0.0997205277692188	0.81890752807928	1.20980481397327	0.995260519973709	1.07970710100411	0.75287476030069	NA	NA	NA	NA	1.22958230282659	0.793292313355698	0.780634300725809	0.805950325985587	0.663301059547784	NA	NA	NA	NA	0.911724865330603	p.Tyr16Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.511	-4.069	2.558	4.483	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16F	16	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.511	-1.803	0.292	34.911	34.911	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.215	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
Y16G	16	Y	G	missense	possibly_wt-like	0.856299041004331	0.276990827448736	6	0.113081031780117	0.634664291380672	1.07793379062799	1.18195783753827	0.776865779680299	0.966001797554689	0.859307212481065	0.364745194947861	NA	NA	0.988916423823807	0.720188761456294	0.869460500557096	0.666345573541188	0.767829739759126	0.672547783153462	0.516375332924291	NA	NA	0.79085089522353	p.Tyr16Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.511	-3.954	2.443	5.819	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16H	16	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.511	-3.235	1.724	17.658	17.658	90.57	0.003636774	0	0.103945055	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Nov 20, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.365	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
Y16I	16	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.511	-3.109	1.598	15.901	15.901	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.58	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16K	16	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.511	-4.078	2.567	4.707	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16L	16	Y	L	missense	possibly_wt-like	0.822226003373218	0.310242652450639	8	0.109687341680574	0.607242764119354	1.03720924262708	1.09318279751181	0.942897245420059	0.863537969960014	1.07610854545829	0.226809553185181	0.654951930962282	0.601092406841467	1.11922757764664	0.730229694112971	0.827223421051688	0.742883285010872	0.71757610321507	0.767626341866262	0.464851152948816	0.614149658225571	0.611331671109436	0.856299419031997	p.Tyr16Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.511	-2.336	0.825	18.077	18.077	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
Y16M	16	Y	M	missense	wt-like	1.02801816450391	0.136572149561066	5	0.0610769220503623	0.908309596998635	1.14772673200918	NA	0.87200534754145	1.12638324926856	1.1817217437943	1.05858402575827	0.901396456156947	NA	NA	0.77555038250398	NA	0.71020331316821	0.84648921766502	0.813943172768273	0.77555038250398	0.735615434289975	NA	NA	p.Tyr16Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.511	-3.11	1.599	4.461	4.461	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16N	16	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.511	-4.295	2.784	4.775	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y16P	16	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr16Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.511	-4.478	2.967	2.529	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y16Q	16	Y	Q	missense	possibly_wt-like	1.00567982216442	0.491662652957809	3	0.283861565035677	0.449321378099316	1.56203826622952	NA	NA	NA	NA	1.42833186930904	NA	1.1226160407048	0.466091556479409	0.892220854543261	NA	NA	NA	NA	0.913665188751312	NA	0.892220854543261	0.528263121466497	p.Tyr16Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.511	-3.622	2.111	4.778	4.778	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16R	16	Y	R	missense	wt-like	0.840504469430741	0.18360224094807	8	0.0649131948077134	0.71327694548619	0.967731993375292	0.924711421496327	0.990628690045573	0.8163550930964	1.02375795816221	0.612163507244552	0.514030573388672	0.935837874803021	0.906550637209172	0.745868303684027	0.747068696243559	0.764886677684072	0.694435145077272	0.744667911124496	0.608795431813135	0.544693369642137	0.791623368452792	0.749482838935885	p.Tyr16Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.511	-4.329	2.818	3.439	NA	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16S	16	Y	S	missense	wt-like	0.907888425113563	0.2661429863385	8	0.0940957552025961	0.723464133818377	1.09231271640875	0.378384265871453	0.693236519815798	1.04363497695514	1.01431939042435	1.16230561160168	0.803490055869538	1.11592216920991	1.05181441116064	0.773216868225614	0.487139063981898	0.627793892187214	0.805905123754953	0.740528612696275	0.814294318357284	0.687360043413717	0.888615579583273	0.822441287150502	p.Tyr16Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.511	-3.371	1.86	19.1	19.1	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y16T	16	Y	T	missense	possibly_wt-like	0.878622335811747	0.379154126651069	5	0.169562880228271	0.546285197449456	1.21095947417404	NA	0.932039781251711	1.06738959643951	1.108168196919	0.211138737906609	NA	NA	1.0743753665419	0.781686151424899	NA	0.737878176755597	0.817555635372891	0.781686151424899	0.458997510652616	NA	NA	0.833772483154031	p.Tyr16Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.511	-3	1.489	7.133	6.651	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16V	16	Y	V	missense	possibly_wt-like	0.86227288488711	0.472303840169483	6	0.192817235328709	0.484358048044257	1.24018772172996	0.812066375017037	1.04177907011438	1.1309772143393	1.11969170541411	NA	-0.0684954974001203	NA	1.13761844183795	0.787602972946496	0.693474828162866	0.788466142057454	0.848742339145845	0.786739803835537	NA	0.257582178146936	NA	0.865536194838003	p.Tyr16Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.511	-3.003	1.492	10.323	5.679	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.32	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16W	16	Y	W	missense	wt-like	0.968849002738745	0.277081701638661	8	0.0979631750857023	0.776844707759577	1.16085329771791	0.342830095511761	1.08953205460019	1.06926756403744	1.20674367510895	1.09991904476141	1.10051580007613	1.0332013959663	0.808782391847772	0.814478076724612	0.470223224577223	0.810479464243745	0.81847668920548	0.824916579310275	0.790990575707067	0.833755920955177	0.844062717659664	0.700378927670184	p.Tyr16Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.511	-3.274	1.763	16.757	16.757	90.57	0.003636774	0	0.103945055	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y16X	16	Y	X	nonsense	low	0.354613210446644	0.263397656194747	5	0.117795012873115	0.123739227656908	0.585487193236381	0.20219646582039	0.198903307136001	0.492793484462012	0.753036704467851	NA	NA	NA	0.126136090346968	0.403313045808074	0.403313045808074	0.399914600551784	0.535743557405531	0.625942688079463	NA	NA	NA	0.357521149146636	p.Tyr16Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.2	99.9	26.9	0.217	63.1	16.2	171.1	-21.7	40.7843137254902	-0.7	0	0	79.73	0	0	0	0	5	15.2144036314277	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	2	4	2	0	1	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q17A	17	Q	A	missense	wt-like	0.921945609325414	0.209545706064487	8	0.0740855948633607	0.776740511620002	1.06715070703083	1.07153802056505	1.00474734143124	1.03631718673141	1.03265275781521	0.967457940870621	0.427953671797128	0.859764371138288	0.975133584254363	0.76102291018365	0.816925344424469	0.771395138362189	0.802316095520878	0.748568739221043	0.741511342715484	0.502268415609266	0.750650682005111	0.783928490830309	p.Gln17Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.139	-3.016	0.877	8.913	8.913	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q17C	17	Q	C	missense	wt-like	1.01074485968661	0.187002341696848	5	0.0836299895971592	0.846833092048723	1.17465662732451	NA	0.949695775268032	1.12242992317856	1.15146581765762	1.12190912417081	NA	NA	0.708223658158055	0.799204702198855	NA	0.746017292854529	0.84455029914977	0.800674389730398	0.799204702198855	NA	NA	0.6498734990636	p.Gln17Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.139	-4.207	2.068	43.772	43.772	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.235	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
Q17D	17	Q	D	missense	possibly_low	0.69709660548531	0.250764557774235	7	0.0947800939285306	0.511331034934067	0.882862176036554	0.85846114443144	0.882855186370125	0.485054979544257	0.525215595447879	0.339298129503172	0.759536145155968	NA	1.02925505794433	0.665696361205025	0.715548370048143	0.715204906270226	0.531948188613829	0.526031389599367	0.506869891378765	0.665696361205025	NA	0.811110895831211	p.Gln17Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.139	-3.359	1.22	14.373	14.373	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.035	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q17E	17	Q	E	missense	possibly_wt-like	0.817698896828319	0.209312228620099	8	0.0740030481212706	0.672655587764444	0.962742205892193	0.867968605446881	0.802064751947289	0.988032630137	1.0770728428426	0.56560748978033	0.545592396831077	0.662912865151195	1.03233959249018	0.699016836210972	0.720071796753264	0.67796187566868	0.778634815846405	0.768049235970331	0.591404998186886	0.56024933046298	0.644627761500375	0.812660097313506	p.Gln17Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.139	-2.59	0.451	10.025	10.025	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.34	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
Q17F	17	Q	F	missense	wt-like	0.985872299212155	0.242945824063413	8	0.0858943198280965	0.817522525872521	1.15422207255179	1.13346002563593	0.960183611291826	0.990693770084027	1.08401423751125	0.406452543595963	1.10639672806747	1.14425597398146	1.06152150352932	0.80362831695875	0.846386380437897	0.750852008755843	0.779939978486042	0.771093395300389	0.531954605334115	0.836654469753866	0.903875979628613	0.827316655431458	p.Gln17Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.139	-4.591	2.452	3.068	NA	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q17G	17	Q	G	missense	wt-like	0.869936716650491	0.140824030811667	8	0.0497888135704767	0.772352435219377	0.967520998081604	0.915084888509492	0.951919651139264	0.953869656061264	1.00241420626545	0.750961682180166	0.58364167948493	0.839808535214086	0.96179343434927	0.741195609258585	0.742488617890395	0.747042462204317	0.761879501090281	0.735307575835043	0.660641800556279	0.579002782756527	0.739902600626776	0.777228426460845	p.Gln17Gly	0	0	NA	NA	NA	NA	NA	NA	NA	1.573	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.139	-3.907	1.768	3.944	NA	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.585	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q17H	17	Q	H	missense	wt-like	1.09232219069472	0.0235299622820658	3	0.0135850300575725	1.06569602105298	1.11894836033645	NA	1.08625359699238	1.07242096372688	1.1182920113649	NA	NA	NA	NA	0.808968150461537	NA	0.808968150461537	0.820023281847891	0.786125965853039	NA	NA	NA	NA	p.Gln17His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.139	-3.806	1.667	20.732	20.732	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.035	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
Q17I	17	Q	I	missense	wt-like	0.912854048789321	0.157488205701911	8	0.0556804891043617	0.803722295503197	1.02198580207544	0.949230819470321	0.830984059032432	0.96296347510285	1.13043092211273	0.868822902595902	1.02216733190628	0.943087692604747	0.595145187489311	0.762537018543706	0.758734450056158	0.691293189535747	0.766339587031254	0.791449503870067	0.704667424791077	0.795140100692213	0.795528072420444	0.593080056885579	p.Gln17Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.902	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.139	-2.586	0.447	14.26	13.543	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.5	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q17K	17	Q	K	missense	possibly_wt-like	0.804621492423175	0.179843603414864	8	0.0635843157638371	0.679998523544432	0.929244461301918	0.461377740019243	0.746978553673241	0.888502655054487	0.943634897175056	0.98860634208132	0.647702239250895	0.81284336818376	0.947326143947394	0.717454579534255	0.526625410199996	0.652568065340766	0.729820094491067	0.709529819242393	0.749411070561375	0.610576483170228	0.725379339826116	0.769962257966946	p.Gln17Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.139	-2.355	0.216	25.026	25.026	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.425	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
Q17L	17	Q	L	missense	wt-like	0.991152929168171	0.102455124377993	8	0.0362233566074951	0.920156454818329	1.06214940351801	0.915977250449739	1.14103608519525	0.955243466594158	1.1059479590123	0.833287336313011	1.04044028472962	0.933066874586637	1.00422417646465	0.785421694356814	0.742913182747889	0.834221955557946	0.762553289848921	0.780712462669072	0.6913935465585	0.804146340104197	0.790130926044555	0.798539184243903	p.Gln17Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.139	-3.052	0.913	11.289	9.97	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
Q17M	17	Q	M	missense	wt-like	0.899365995549952	0.218871269929703	8	0.077382679587102	0.747698730532029	1.05103326056787	1.0571011080165	1.0662450951979	1.0035438886666	1.10166755087056	0.463275494867864	0.778568597706509	0.9702082247344	0.75431800433927	0.78253881693384	0.81005660042904	0.799744567868546	0.786242350786159	0.77883528308152	0.553180127111208	0.675076937290594	0.810135011837087	0.673024294870216	p.Gln17Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.139	-3.096	0.957	5.989	5.989	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q17N	17	Q	N	missense	wt-like	1.13540925479657	0.171581768644463	4	0.0857908843222316	0.967262211323158	1.30355629826999	0.882687795601035	NA	1.227388074986	1.25498244093121	NA	NA	NA	1.17657870766805	0.865587838528782	0.727074841805239	NA	0.896027283145835	0.84607176440753	NA	NA	NA	0.885103912650035	p.Gln17Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.139	-2.883	0.744	11.003	11.003	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q17P	17	Q	P	missense	wt-like	0.954703702419106	0.0995336544947118	6	0.0406344442910869	0.875061655076777	1.03434574976144	NA	0.951492856690373	0.963516261760637	1.11707034775251	0.894466999732208	NA	0.818217270305576	0.983458478273334	0.756728209877426	NA	0.74684571714614	0.766610702608711	0.78559020339299	0.714246465126663	NA	0.728273688002954	0.788109652675781	p.Gln17Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.139	-3.721	1.582	10.435	10.435	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.685	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
Q17Q	17	Q	Q	synonymous	possibly_wt-like	0.800892099083547	0.20230344669179	6	0.0825900362668705	0.639018602518624	0.96276559564847	NA	1.01067145432434	0.869661357149132	0.487108020999902	0.636334262148041	0.828683192191537	NA	0.972894307688331	0.710178192910832	NA	0.774126054705699	0.720579333539802	0.509319254093563	0.617824123091733	0.699777052281862	NA	0.78280381852601	p.Gln17=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	NA	NA	NA	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q17R	17	Q	R	missense	wt-like	0.84294378579191	0.163923048917754	8	0.0579555497412588	0.729352995594823	0.956534575988997	1.04005539987935	0.917496897870611	0.84866647225516	0.70768455473737	0.94898772907113	0.60224808548504	1.00675961196028	0.671651535076345	0.720728246407171	0.801946652750048	0.731174152267223	0.710282340547118	0.60605343291813	0.73461201992421	0.588173372132726	0.829821347497841	0.631505221306704	p.Gln17Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.139	-2.688	0.549	16.562	16.562	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
Q17S	17	Q	S	missense	wt-like	0.883376130469478	0.220567555751841	8	0.0779824071909342	0.73053342094751	1.03621883999145	0.405731994679232	0.93334576481614	1.05428615130018	1.11264992823288	0.898057046891701	0.772082939128956	0.882856624182416	1.00799859452433	0.750784115060626	0.500150471192779	0.738480213199672	0.811129018439236	0.783651621599874	0.715587483543675	0.67188033330116	0.763088016921581	0.800434878380553	p.Gln17Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.139	-3.259	1.12	5.13	5.13	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.035	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q17T	17	Q	T	missense	possibly_wt-like	0.88357474903005	0.313133183692997	6	0.127836086930173	0.63302062272238	1.13412887533772	0.402615496514449	1.25099342918484	0.835285110592582	1.21087612043984	0.780898818460373	NA	NA	0.820779518988215	0.705061940117978	0.498667714544906	0.88491044060354	0.703719418770314	0.826728869579091	0.671824453407567	NA	NA	0.706404461465641	p.Gln17Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.139	-2.369	0.23	12.57	12.57	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.68	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q17V	17	Q	V	missense	wt-like	1.02067321224283	0.104112388789255	8	0.0368092880592061	0.948528333350228	1.09281809113544	0.873740193897825	1.0422973607333	1.04947613347036	1.11574543707229	1.18735555732315	0.951906413929113	1.0306741534896	0.914190448027005	0.786857113541197	0.722817783014744	0.788705065310175	0.808769933350729	0.78500916177222	0.823651420664094	0.760510413048097	0.842701561559487	0.753319919074727	p.Gln17Val	0	0	NA	NA	NA	NA	NA	NA	NA	-0.545	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.139	-2.593	0.454	23.382	23.382	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q17W	17	Q	W	missense	possibly_wt-like	0.764850326164717	0.304784447394361	8	0.107757574776374	0.553649360541644	0.976051291787791	0.889734280986874	0.742080095263625	0.955251569012793	0.952997937203187	0.904144670270654	0.0335486542760735	0.852805799895858	0.788239602408676	0.715748718016565	0.730427394092309	0.650309958452828	0.762557263700091	0.713635994877108	0.717861441156021	0.307876953680668	0.746902841509997	0.690061351589744	p.Gln17Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.139	-5.771	3.632	0.531	NA	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q17X	17	Q	X	nonsense	low	0.265309479277383	0.213055576164126	4	0.106527788082063	0.0565188512838245	0.474100107270942	NA	0.0222485927166006	0.221998040453336	0.277692343230807	NA	NA	NA	0.539298940708788	0.410205475478773	NA	0.318479750225376	0.402931265102435	0.41747968585511	NA	NA	NA	0.565031387951239	p.Gln17Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	1	1	1	2	1	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q17Y	17	Q	Y	missense	possibly_low	0.648980428010514	0.326364990129499	5	0.145954860681121	0.362914157706955	0.935046698314073	NA	0.472896673591756	NA	NA	0.92166233553916	0.160286234748136	0.895047689310744	0.795009206862774	0.69346137227324	NA	0.526220931300367	NA	NA	0.724404951785403	0.370342445889936	0.769654044051968	0.69346137227324	p.Gln17Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	102.6	25.1	0.848	67.6	-112.7	-175.9	137	35.981308411215	-0.9	0	0	66.47	0	0	0	0	6	16.4092442805877	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.139	-4.581	2.442	3.399	NA	90.32	0.003579959	0	0.102321199	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.585	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E18A	18	E	A	missense	possibly_wt-like	0.941364714532718	0.404428083377745	6	0.165107073654541	0.617760796577016	1.26496863248842	NA	1.04909424541561	0.892171897586528	1.23902035007559	1.21421901622748	NA	1.0974190106293	0.156263767261814	0.812762126752867	NA	0.791838314760145	0.73161968352581	0.839071564861918	0.833685938745589	NA	0.878649900624193	0.372652716338006	p.Glu18Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.095	-2.873	0.778	11.5	11.5	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E18C	18	E	C	missense	wt-like	0.917617290862704	0.235712626762433	8	0.0833369983975051	0.754279775423921	1.08095480630149	0.560981634320106	1.04667756183322	1.07747155980086	1.2533324137883	1.0187002035038	0.609857320512191	0.885273272505712	0.888644360637441	0.762520936961643	0.574014604295318	0.790724264300384	0.822500359128632	0.845348142460974	0.760652266181844	0.591923756269276	0.764389607741442	0.740489446320244	p.Glu18Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.095	-3.746	1.651	17.749	17.749	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.245	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E18D	18	E	D	missense	wt-like	0.909297834584841	0.0558003421308121	3	0.0322163425500976	0.846154963473045	0.972440705696638	0.852303432511338	0.91176799619855	0.963822075044635	NA	NA	NA	NA	NA	0.728533225011292	0.712618675306657	0.728533225011292	0.766760689486863	NA	NA	NA	NA	NA	p.Glu18Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.095	-2.479	0.384	20.377	20.377	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
E18F	18	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu18Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.095	-3.682	1.587	8.895	8.895	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E18G	18	E	G	missense	wt-like	0.96493368079838	0.0803016375586769	8	0.0283909162290624	0.909288507501324	1.02057885409544	0.994494665475758	0.956430284563949	0.984158433325345	1.02463874898303	0.79274168292192	0.912377666618869	1.02169249020171	1.03293547429645	0.762928247390842	0.780269925138821	0.749121788301125	0.77673470648056	0.745054183296449	0.676248211271337	0.741027773029618	0.837864097055484	0.81295937779289	p.Glu18Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.095	-3.179	1.084	18.598	18.598	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E18H	18	E	H	missense	possibly_wt-like	0.895706457234911	0.417437143556925	6	0.170418000233233	0.561693314460437	1.22971960000939	NA	0.458937792341531	0.876349605400067	NA	1.41784137588639	0.353497652698821	1.14184024974909	1.12577206733357	0.791722988812134	NA	0.519786121965829	0.72385960136318	NA	0.909746592627546	0.465571077190819	0.902574886518018	0.859586376261089	p.Glu18His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.095	-3.827	1.732	31.977	31.977	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E18I	18	E	I	missense	possibly_wt-like	0.751076337859385	0.288136406824427	2	0.203743207172278	0.351746989707037	1.15040568601173	NA	0.547333130687107	NA	NA	NA	NA	NA	0.954819545031663	0.667130344695082	NA	0.560534885288579	NA	NA	NA	NA	NA	0.773725804101584	p.Glu18Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.095	-3.575	1.48	6.199	6.199	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E18K	18	E	K	missense	possibly_low	0.692516625327712	0.621408917730508	3	0.358770605928543	-0.0106608410038441	1.39569409165927	NA	NA	NA	NA	-0.0220978646554098	0.993755688035349	NA	1.1058920526032	0.781136777350695	NA	NA	NA	NA	0.371874816810006	0.781136777350695	NA	0.849601677490311	p.Glu18Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.095	-2.221	0.126	11.482	11.482	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E18L	18	E	L	missense	wt-like	0.910302036192976	0.280362995296811	8	0.0991232875840737	0.716023962498985	1.10458010988697	1.154048452098	0.867564044725067	1.08325443835213	1.12144958347507	0.361914954426546	1.14757416275859	0.67348913985805	0.873121513850353	0.76010192532564	0.856181870308817	0.708155947315025	0.825336586153488	0.787510723968426	0.515318131028315	0.856949702756698	0.650324073178857	0.732693126682854	p.Glu18Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.095	-3.191	1.096	13.045	13.045	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E18M	18	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu18Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.095	-3.511	1.416	5.426	5.426	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E18N	18	E	N	missense	wt-like	0.88755655188452	0.166221209789935	8	0.0587680723097475	0.772373246716569	1.00273985705247	0.8251173497112	0.887177453239217	0.849279524759252	1.03914905633409	0.533832930162763	1.04586225465047	1.00681495354472	0.913218892674445	0.734307549751834	0.699684175470579	0.717197398555033	0.710583013657291	0.751417700948635	0.579535998213741	0.806818681004097	0.829851154109575	0.752831957286669	p.Glu18Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.095	-3.059	0.964	8.724	8.724	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E18P	18	E	P	missense	wt-like	0.8715260796907	0.131589869587747	8	0.0465240445604745	0.780340627937034	0.962711531444367	0.951241089992855	0.986575619086657	0.908266088442488	1.048897970497	0.70147032291929	0.6794127751099	0.817411298937339	0.878933472540069	0.737562645351165	0.759690889567336	0.763018280183408	0.739513119060401	0.755693102279872	0.642154905731984	0.626205740279875	0.727839597149164	0.735612171641929	p.Glu18Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.095	-4.347	2.252	2.405	NA	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.245	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E18Q	18	E	Q	missense	wt-like	1.08552627786457	0.245880550310862	3	0.141959201910469	0.807291354846002	1.36376120088314	NA	NA	NA	NA	0.805996693910436	1.18222537825317	1.26835676143011	NA	0.874028340548712	NA	NA	NA	NA	0.681199459281074	0.874028340548712	0.970715843800676	NA	p.Glu18Gln	1	0	NA	NA	NA	NA	NA	NA	NA	-3.158	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.095	-2.416	0.321	9.661	9.661	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.395	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E18R	18	E	R	missense	wt-like	0.877041460716782	0.0861204614713944	8	0.0304481811526689	0.8173641222628	0.936718799170764	0.917936695054377	0.994494945563688	0.803337613595307	0.891385508135381	0.841022018260992	0.95708056540702	0.885793015068292	0.725281324649199	0.719064091665733	0.743845440480782	0.766668956410547	0.688050690202568	0.686615769151942	0.694282742850685	0.763060611005395	0.764669537651651	0.658440678915145	p.Glu18Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.095	-2.868	0.773	10.5	10.5	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E18S	18	E	S	missense	wt-like	0.895649293011479	0.256084455154716	8	0.0905395273981808	0.718195080133767	1.07310350588919	1.06134461047358	0.837942931377676	0.609402422462251	0.424715596364746	1.14118906746331	1.00749968729313	0.973801860242137	1.10929816841501	0.797158654784496	0.812075559255839	0.694501112572152	0.592934698177993	0.481956960110201	0.806406490332985	0.787910819236008	0.812070520178003	0.851312392538592	p.Glu18Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.095	-3.179	1.084	8.365	7.422	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E18T	18	E	T	missense	possibly_wt-like	0.87001426719534	0.242728793448707	8	0.0858175879184049	0.701814885635166	1.03821364875551	0.301528298951641	0.812587088114907	0.917590174658045	1.02082840909948	1.05046214225214	1.02504321413721	0.908734927313765	0.923339883035529	0.751000672566967	0.450572799587202	0.682812495555675	0.744086140103843	0.743383152867995	0.772516551782913	0.796557544503449	0.777025900007283	0.757915205030091	p.Glu18Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.095	-3.255	1.16	22.272	22.272	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E18V	18	E	V	missense	wt-like	0.991835457608507	0.145140956330286	8	0.0513150772245227	0.89125975438455	1.09241116083246	1.1361998323628	0.986296708053931	0.695761799898586	0.891146958949889	1.10659460927804	1.10751895960378	0.975074583765215	1.0360902089558	0.803120076116628	0.847689916144755	0.762889706891271	0.635289867487343	0.686511153038991	0.79348415157475	0.837207587029955	0.812756000658506	0.81454383714579	p.Glu18Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.095	-3.263	1.168	8.484	8.484	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E18W	18	E	W	missense	wt-like	0.954504334851857	0.183329352218367	6	0.0748438946349957	0.807812996904555	1.10119567279916	0.945485172062249	0.936179997467854	0.82280669816719	1.02268381832292	1.26593375250339	NA	0.733936570587539	NA	0.741991796097865	0.75695235897147	0.739786746753226	0.697599350670252	0.744196845442503	0.853003348990064	NA	0.682880659986826	NA	p.Glu18Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.095	-3.998	1.903	15.894	15.894	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E18X	18	E	X	nonsense	low	0.0838244507922979	0.067759092814196	5	0.030302787525252	0.0244320786116344	0.143216822972961	0.00780720056650833	0.126787035966905	0.0939279637143179	0.16732541791393	NA	NA	NA	0.0232746357998279	0.340118980614378	0.31082719788191	0.36667021322787	0.340118980614378	0.369078100659164	NA	NA	NA	0.305859183463677	p.Glu18Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E18Y	18	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu18Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.8	106	25.5	0.585	31.9	178	-72.1	118.5	16.3551401869159	-4.5	0	0	63.19	1	2	1	42	6	19.0461811883642	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.095	-3.038	0.943	11.341	11.341	90.32	0.003612946	0	0.103264023	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D19A	19	D	A	missense	wt-like	0.875620980711325	0.102061122734212	8	0.036084055990437	0.804897530553942	0.946344430868708	1.00880319361859	0.90809198413187	0.864121552083828	0.923895103748494	0.943642399568001	0.727798556250329	0.908285589883967	0.720329466405517	0.722350483909442	0.787077586848624	0.726838645314215	0.717862322504669	0.700872902412075	0.732615337153696	0.650053770387511	0.776783889836416	0.655953617733886	p.Asp19Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.603	-2.805	1.202	9.489	7.978	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D19C	19	D	C	missense	possibly_low	0.619867874127646	0.225921811505315	8	0.0798754224666787	0.463314922843034	0.776420825412257	0.886611363730771	0.91275808389844	0.676233588999597	0.684783259093937	0.439994184542952	0.41695248890855	0.664438838530393	0.277171185316525	0.610861121392508	0.728941583391513	0.728989638778202	0.625712208366941	0.596010034418076	0.544483677028281	0.496846233005972	0.645449640680134	0.433378232128714	p.Asp19Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.603	-5.486	3.883	1.583	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.4	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D19E	19	D	E	missense	wt-like	0.961582135641724	0.136031369172628	8	0.0480943517980278	0.86731893825779	1.05584533302566	0.946935644837275	0.951110448910432	1.02534966500434	1.16576467699419	0.946724133945907	0.993775752468696	0.98698149071987	0.676015272253078	0.769394563210502	0.757642459859073	0.746669433595342	0.796937047484125	0.806945176529949	0.733766481518522	0.781146666561931	0.819168982074017	0.633696899824826	p.Asp19Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.603	-2.193	0.59	13.563	13.563	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.17	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D19F	19	D	F	missense	possibly_low	0.513433505986566	0.377476971918378	6	0.154104328475153	0.211394572313536	0.815472439659597	0.491339505116039	0.497259838602289	0.309065756850507	0.0456360871729799	NA	1.18387728643054	NA	0.553422561747044	0.53916622742277	0.540880514496638	0.537451940348901	0.445633840999294	0.315711057114326	NA	0.874842520975698	NA	0.572124949175021	p.Asp19Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.603	-3.512	1.909	11.956	11.956	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D19G	19	D	G	missense	wt-like	0.842904988048291	0.162034532735642	8	0.0572878584418831	0.730622848750771	0.955187127345811	1.00439579884496	0.962887538472297	0.912221308799341	0.768046420570005	0.780845977730514	0.498090628005393	0.880256052615949	0.936496179347867	0.746775720151817	0.784980651905985	0.752098473680138	0.741452966623497	0.632525222209136	0.671804715396125	0.536837005882889	0.761687366258149	0.764522929289827	p.Asp19Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.603	-2.15	0.547	27.833	27.833	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.555	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D19H	19	D	H	missense	possibly_low	0.538782382101053	0.443634472614182	2	0.313696943953606	-0.0760523301082946	1.1536170943104	NA	NA	NA	NA	NA	0.225085438147447	NA	0.852479326054658	0.562302915774545	NA	NA	NA	NA	NA	0.402280203578143	NA	0.722325627970947	p.Asp19His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.603	-3.382	1.779	14.671	14.671	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.595	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D19I	19	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp19Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.603	-4.384	2.781	2.614	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.05	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D19K	19	D	K	missense	possibly_low	0.633710634399675	0.311276842986203	6	0.127078239010106	0.384641862721095	0.882779406078256	NA	0.54895259750508	0.883909687137813	NA	0.644014235461454	0.0579678591104772	0.794354261363203	0.873065165820024	0.668057056345784	NA	0.561281432236753	0.72756746206691	NA	0.620692883639408	0.319912512854659	0.71542122905216	0.732664825994107	p.Asp19Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.603	-2.772	1.169	11.138	11.138	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D19L	19	D	L	missense	wt-like	0.809827097931295	0.0838433124043558	8	0.0296430873791311	0.751727714277624	0.867926481584966	0.762789962996646	0.778972629953678	0.721057486126634	0.793798491804144	0.844460136335696	0.935404503142287	0.719369531065886	0.92276404202539	0.672532608568218	0.670030268389914	0.667316796059854	0.647696199084337	0.643818832738129	0.695567010007413	0.752377071888726	0.675034948746523	0.757625990001628	p.Asp19Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.603	-3.966	2.363	3.965	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D19M	19	D	M	missense	possibly_wt-like	0.761943498928553	0.135194072147478	8	0.0477983225958526	0.668260508119255	0.855626489737852	0.834572566827592	0.724888799088959	0.788803530927418	0.808999626294959	0.615736123413295	1.02752775555817	0.636183985401512	0.658835603916525	0.646435186967702	0.704182745755278	0.64238506023824	0.680922413570324	0.650485313697164	0.610129939095729	0.797782107116971	0.630231763467893	0.625068444783479	p.Asp19Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.603	-4.006	2.403	3.256	3.256	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D19N	19	D	N	missense	wt-like	1.14509188612619	0.13943476239176	5	0.0623571214269012	1.02287417394987	1.2673095983025	1.03146657830755	1.27952041149279	1.09607730350655	1.30749811312307	NA	NA	NA	1.01089702420098	0.831625591942661	0.797860293121511	0.898060899350974	0.831625591942661	0.86910259338477	NA	NA	NA	0.801890609053902	p.Asp19Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.603	-2.451	0.848	12.182	12.182	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.2	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D19P	19	D	P	missense	wt-like	0.970758734362805	0.121230116347077	8	0.042861318676526	0.88675209342692	1.05476537529869	0.738484422623846	0.910579850669551	0.907548986373211	1.10464293892472	1.10025330774519	0.951598645423463	1.02212099383759	1.03084072930487	0.77024943322759	0.658466263002342	0.727985509918389	0.739161414584779	0.780140144098356	0.791115435575881	0.760358722356824	0.838094886282598	0.811907296191028	p.Asp19Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.603	-3.558	1.955	10.312	10.312	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.4	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D19Q	19	D	Q	missense	possibly_low	0.665651408914862	0.229876145196505	8	0.0812734905507362	0.506358294537562	0.824944523292161	0.941164238207489	0.762956600166414	0.834670481303908	0.6521110772349	0.475489340198511	0.270563146775691	0.518206781792376	0.870049605639604	0.620807637289928	0.75489656010383	0.659933675870643	0.703417972322261	0.581681598709214	0.557742460362911	0.424694924164032	0.566690021092588	0.731150266752829	p.Asp19Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.603	-2.896	1.293	6.052	6.052	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D19R	19	D	R	missense	wt-like	0.903656013591753	0.0785680149727589	8	0.027777988085802	0.849212157380598	0.958099869802907	1.02461517118641	0.87563505182341	0.946449181378556	0.995287120485742	0.883864841405009	0.794879697697107	0.869465792032793	0.839051252724995	0.723881692807186	0.794600554492125	0.711876545755871	0.758240111010454	0.73218198138204	0.710286157937032	0.68311623301955	0.755875803200519	0.715581404232332	p.Asp19Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.603	-4.109	2.506	4.309	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D19S	19	D	S	missense	wt-like	0.982043626612201	0.0917982802149913	8	0.0324555932206416	0.918431832802861	1.04565542042154	0.949173482158209	0.913233533435175	0.939720949687109	1.05123316050768	1.0875551734419	1.12468102115195	0.888517540629938	0.902234151885646	0.757712186883732	0.758707170309401	0.729208813013031	0.754940233210225	0.756717203458063	0.786372202073399	0.845666298470861	0.766136949117908	0.747314892569224	p.Asp19Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.603	-3.234	1.631	19.1	19.1	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.425	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D19T	19	D	T	missense	possibly_wt-like	0.796982438837225	0.250297368833716	8	0.0884934834077354	0.623538398491571	0.970426479182879	0.951461475269149	0.948922084739588	0.939816394948921	1.03306614688256	0.362725357416558	0.878979780301305	0.450607911024824	0.810280360114897	0.735113750751151	0.759795743706898	0.745660634541786	0.754987044573899	0.748750031633648	0.515620847200702	0.724566866960516	0.530281715930482	0.701131279321744	p.Asp19Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.603	-3.882	2.279	7.133	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D19V	19	D	V	missense	wt-like	0.820660513650636	0.0956880047052315	8	0.0338308185026397	0.75435332781795	0.886967699483321	0.808918832926105	0.874789648230251	0.881411895517068	0.845182579237268	0.840579935408525	0.877845099549482	0.844971139358267	0.591584978978118	0.70280221855477	0.691977301543878	0.711486828927195	0.726342414016116	0.666353403475418	0.694117608182346	0.724007613806093	0.742683145108928	0.59129194907844	p.Asp19Val	1	0	NA	NA	NA	NA	NA	NA	NA	-0.878	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.603	-4.035	2.432	3.58	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.4	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D19W	19	D	W	missense	possibly_wt-like	0.735226506431502	0.157733994101913	7	0.0596178459563702	0.618377675521159	0.852075337341844	0.525732957847353	0.76671855054893	0.690820074005094	0.552510664871789	0.935096154354362	NA	0.774484547628544	0.901222595764442	0.661667871685018	0.557244111708704	0.661667871685018	0.632866185854696	0.538001684362563	0.729422991282281	NA	0.704719532516093	0.746806840472837	p.Asp19Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.603	-5.668	4.065	1.412	NA	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.4	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D19X	19	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp19Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D19Y	19	D	Y	missense	wt-like	1.01239277681083	0.0920643521759047	3	0.0531533785115271	0.908214069271616	1.11657148435005	0.914207371194808	NA	1.09677803598108	1.02619292325662	NA	NA	NA	NA	0.745735768819432	0.742071115757176	NA	0.83196926791023	0.745735768819432	NA	NA	NA	NA	p.Asp19Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	108.6	23.4	0.142	57.9	92.6	-120.9	40.7	54.5454545454545	-0.9	0	0	66.95	1	3	0	0	5	22.1492644993011	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.603	-3.297	1.694	16.303	16.303	86.85	0.003404862	0	0.097316635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G20A	20	G	A	missense	wt-like	0.8531795567101	0.118250203235501	7	0.0446943757491402	0.765580189930284	0.940778923489915	NA	0.900161619935093	0.926059578306768	0.946579902450209	0.931363389950012	0.847007284662204	0.812559209195996	0.608525912470416	0.723182880884032	NA	0.723182880884032	0.748239979977867	0.710821355844673	0.728028662575661	0.708808497029387	0.725226293672776	0.59980050000813	p.Gly20Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.28	-3.404	2.124	9.895	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G20C	20	G	C	missense	possibly_wt-like	0.818745760751952	0.225586002070198	7	0.0852634943907209	0.651632382550106	0.985859138953798	NA	0.832729787496477	0.812193381937841	0.991766092288666	0.629476053744367	1.1334327651783	0.449558025029463	0.882064219588552	0.69239402359203	NA	0.692097940977831	0.69239402359203	0.73063782903958	0.615262322823255	0.849979794091174	0.529716254270095	0.73718458326388	p.Gly20Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.28	-5.446	4.166	1.651	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20D	20	G	D	missense	wt-like	1.07746659767115	0.335677758887808	5	0.150119657481585	0.783237475635752	1.37169571970654	NA	0.942984326583149	1.05054624241716	0.915878104443421	1.65945922740996	NA	NA	0.818465087502045	0.742923427961519	NA	0.742923427961519	0.809294770918652	0.697357035010983	1	NA	NA	0.705242042748732	p.Gly20Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.28	-2.48	1.2	18.113	18.113	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.915	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G20E	20	G	E	missense	wt-like	0.963849319525736	0.105970557019232	7	0.0400531057382684	0.885346674809756	1.04235196424172	NA	1.14017824657725	0.873914284686467	0.979060606909032	1.06383485560615	0.870734872265625	0.9509392105592	0.868283160076429	0.730263072900988	NA	0.833826506392094	0.72266519232262	0.725065818844564	0.777511766078561	0.720503176958304	0.799756848114855	0.730263072900988	p.Gly20Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.28	-2.302	1.022	11.057	11.057	90.57	0.002969749	0	0.084880364	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jan 5, 2017)	criteria provided, single submitter	0	0	1	0	0	3	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.42	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G20F	20	G	F	missense	wt-like	0.871718418613939	0.184438243638408	8	0.0652087663934274	0.743911585006536	0.999525252221343	0.625217169157665	1.0684691741846	0.91456249242501	1.0788620666203	0.890153831347074	0.576094195036542	0.950257345113209	0.870131075027103	0.736896195245943	0.604576363447416	0.800769830851147	0.742601205897484	0.768833902815607	0.712635333577918	0.575282833793841	0.799389599890806	0.731191184594402	p.Gly20Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-1.699	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.28	-3.673	2.393	33.476	33.476	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20G	20	G	G	synonymous	wt-like	0.984029350902191	0.108848627727506	8	0.0384838013944849	0.908602486180809	1.05945621562357	0.8093151393975	0.97632836324193	0.952315965918384	1.14899889779264	1.10692784560877	0.999664997682046	0.890409973117878	0.988273624458383	0.775602757722304	0.69216585485724	0.758294467695786	0.761117489934	0.799592518221577	0.793608627949815	0.784049314692208	0.7671562007524	0.790528050491228	p.Gly20=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G20H	20	G	H	missense	wt-like	0.913933658684351	0.213081611747358	7	0.080537279092047	0.756083492251088	1.07178382511761	NA	1.30087871611303	0.985224844132756	0.776214947006657	0.68417354808365	1.0306220195367	0.736983289000258	0.883438246917402	0.737874685820012	NA	0.907906718330056	0.777257730286914	0.636107542067316	0.635693906035037	0.799307185327592	0.684521602393907	0.737874685820012	p.Gly20His	0	0	NA	NA	NA	NA	NA	NA	NA	-0.57	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.28	-3.773	2.493	10.015	10.015	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20I	20	G	I	missense	possibly_wt-like	0.967527527839018	0.459427467650623	5	0.205462209679476	0.564828996683229	1.37022605899481	0.706938685464106	0.738106943013562	0.5314557653639	1.20167701794357	1.65945922740996	NA	NA	NA	0.648478402131949	0.643457541991621	0.648478402131949	0.554705568273341	0.822694589001632	1	NA	NA	NA	p.Gly20Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.28	-4.355	3.075	5.579	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20K	20	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly20Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.28	-2.943	1.663	8.525	8.525	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20L	20	G	L	missense	wt-like	0.840083497653014	0.0570133684922756	8	0.0201572697395878	0.800575974936763	0.879591020369265	0.827437196866344	0.824443996877614	0.805743833209552	0.831184070535231	0.956187398604566	0.788472963038908	0.793989535392327	0.89320898669957	0.695009365405816	0.70078790427434	0.688278330948737	0.689230826537293	0.660214335909546	0.737301368841316	0.679958528474552	0.715224790054031	0.742782020890723	p.Gly20Leu	0	0	NA	NA	NA	NA	NA	NA	NA	-0.567	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.28	-3.949	2.669	9.918	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20M	20	G	M	missense	wt-like	0.844036338084939	0.171200420632367	8	0.060528489185568	0.725402679242603	0.962669996927274	0.842020552954509	0.782081787434452	0.645839222316538	0.726882655819256	0.828500027567081	0.79413528956839	1.21919160749948	0.913639561519806	0.68617732011605	0.707726322667257	0.668750065332742	0.610805216386128	0.614472789735831	0.689605305649397	0.682749334582703	0.944235816733308	0.753043237396877	p.Gly20Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.28	-5.096	3.816	2.18	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20N	20	G	N	missense	wt-like	0.993596149839787	0.252040870149519	4	0.126020435074759	0.74660063577719	1.24059166390238	NA	0.704212689680999	1.0418606557281	1.30836218721543	NA	NA	NA	0.919949066734621	0.780623538835806	NA	0.632853721770973	0.805034903540179	0.869481534409691	NA	NA	NA	0.756212174131433	p.Gly20Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.28	-2.536	1.256	15.247	15.247	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G20P	20	G	P	missense	possibly_wt-like	0.848242767608899	0.289357590247945	7	0.109366889109284	0.633887603853516	1.06259793136428	1.005597286206	0.8528970761284	0.651363622563117	0.708381912436231	0.408524781389006	1.29173277654183	1.01920191799771	NA	0.701394721630574	0.785552291380074	0.701394721630574	0.613514672089986	0.606359260211738	0.532728664537642	0.928001546516342	0.836522691321895	NA	p.Gly20Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.28	-4.204	2.924	2.637	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20Q	20	G	Q	missense	wt-like	0.92061115686805	0.164669764786093	6	0.0672261499650088	0.788850324117344	1.05237198961876	NA	0.916751213311137	0.906785605876216	1.07133519591981	0.609701916759363	1.00023714275975	NA	1.01885586658202	0.752159997404887	NA	0.730830404234848	0.73878701274033	0.765532982069444	0.607875934650806	0.784331309375717	NA	0.805887922175476	p.Gly20Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.28	-3.108	1.828	5.892	5.892	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20R	20	G	R	missense	possibly_wt-like	0.806281327816237	0.171915803982296	8	0.0607814153945093	0.687151942713631	0.925410712918844	1.10062056464503	0.901799646056704	0.772767164394725	0.840673712520246	0.790369304099909	0.550077270867162	0.613010837465715	0.880932122480405	0.674209688078666	0.830762136006422	0.723937983358838	0.673057338117462	0.664376033027573	0.675362038039871	0.562459802393382	0.617750859097252	0.736615989691017	p.Gly20Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.28	-3.458	2.178	12.549	12.549	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	medium	2.73	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G20S	20	G	S	missense	possibly_wt-like	0.867774855144923	0.288358960806982	8	0.101950288301261	0.667955961860976	1.06759374842887	1.0327752154689	0.884691051969587	0.811606541240278	0.908872514323521	1.03772179053615	1.02592855989657	0.188259651249985	1.05234351647439	0.741904378947286	0.79848291195459	0.71605120941477	0.692106206126912	0.69428472266684	0.767757548479801	0.79699390724943	0.388982676580041	0.822707029266265	p.Gly20Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.28	-2.855	1.575	19.919	19.919	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
G20T	20	G	T	missense	wt-like	0.982200108079512	0.117669903989181	8	0.0416025935261598	0.900660523104779	1.06373969305424	1.11234117608988	0.884790738753057	0.974930789360834	1.13205023820727	1.05438573930058	0.788172035724777	0.912435580977768	0.998494566221924	0.776500605660464	0.836338527718558	0.716097163344265	0.772208985776616	0.792159657439032	0.773982163700845	0.679810209619747	0.779019047620083	0.795661498632325	p.Gly20Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.28	-3.126	1.846	7.872	7.872	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20V	20	G	V	missense	possibly_wt-like	0.70892091375341	0.271320709300848	8	0.0959263567114868	0.520908709430754	0.896933118076066	1.01399756051478	0.860552737998434	0.821073179012207	0.644504367556912	0.245202561658456	0.732324715399029	0.389737525074505	0.963974662812954	0.674516866277306	0.789548944648172	0.704923852911247	0.696749141932186	0.578345664456421	0.471721637377329	0.652284590622425	0.497497328235087	0.778323944218529	p.Gly20Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.28	-3.416	2.136	6.614	6.614	90.57	0.002969749	0	0.084880364	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 21, 2015)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G20W	20	G	W	missense	possibly_wt-like	0.780817192546597	0.290274814743778	3	0.167590242431289	0.452346353220934	1.10928803187226	NA	0.47338013658492	1.05017010356616	0.818901337488708	NA	NA	NA	NA	0.654827724401765	NA	0.526443799603747	0.809110292693001	0.654827724401765	NA	NA	NA	NA	p.Gly20Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.28	-5.572	4.292	1.555	NA	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G20X	20	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly20Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G20Y	20	G	Y	missense	possibly_wt-like	0.821675119723161	0.205679350361187	4	0.102839675180594	0.6201130601874	1.02323717925892	0.781284219271514	0.971509497879437	0.546906474084833	NA	NA	NA	NA	0.987000287656861	0.717451226561161	0.678829401259267	0.756073051863055	0.562283406410341	NA	NA	NA	NA	0.7898885195568	p.Gly20Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.6	111.9	24.1	0.677	126.1	-3	-89.7	-29.2	64.9484536082474	-0.3	0	0	69.94	0	0	0	0	3	24.8191143649406	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.28	-3.654	2.374	7.764	7.325	90.57	0.002969749	0	0.084880364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F21A	21	F	A	missense	wt-like	0.928378884983948	0.125072128150891	8	0.044219674976464	0.841709914622011	1.01504785534588	1.08776859270438	0.979833370476162	0.960620950012758	1.06422242157461	0.861500862976109	0.908181495137173	0.86755605786683	0.697347329123557	0.7573787250198	0.824647469536018	0.759910217043041	0.765190689832738	0.762413663918102	0.701932366017748	0.738959594703802	0.754847232996559	0.644410883939104	p.Phe21Ala	0	0	NA	NA	NA	NA	NA	NA	NA	0.485	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.391	-3.543	2.152	9.895	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21C	21	F	C	missense	possibly_wt-like	0.910502801350021	0.291951180725913	7	0.110347174167491	0.694226314185969	1.12677928851407	0.556094730216353	1.13453507675876	1.08915326856295	1.32824825367292	0.912097473546403	NA	0.7763342917893	0.577056514903461	0.720832114015138	0.571689530072834	0.831225100077829	0.828229681955276	0.87820259950316	0.720832114015138	NA	0.70571579249961	0.583995056226248	p.Phe21Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.391	-3.828	2.437	17.029	17.029	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.75	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.857142857142857
F21D	21	F	D	missense	possibly_wt-like	0.924269188412593	0.216430061400738	3	0.124955954210443	0.679360018506288	1.1691783583189	1.10844776325368	NA	0.978469548284864	NA	0.685890253699234	NA	NA	NA	0.773944578804516	0.834486133312868	NA	0.773944578804516	NA	0.636335160521346	NA	NA	NA	p.Phe21Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.391	-4.235	2.844	4.437	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F21E	21	F	E	missense	possibly_wt-like	0.808542418051487	0.213091182907316	8	0.075339110222413	0.660880475388264	0.95620436071471	0.947591140903515	0.878473897702243	1.0009083128928	1.03880459415948	0.774041665909124	0.697395447340788	0.375849307330836	0.755274978173112	0.693345069524159	0.757954329495594	0.713185205929489	0.784949726158231	0.751266636531071	0.669263047539911	0.635068908315404	0.490017225919354	0.67350493311883	p.Phe21Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.391	-4.094	2.703	4.675	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21F	21	F	F	synonymous	wt-like	1.08036869141066	0.152495384755252	4	0.076247692377626	0.93092596044622	1.22981142237509	NA	0.971617177019964	NA	NA	1.24275142078855	1.17629535622366	0.930810811610461	NA	0.816629848296884	NA	0.756122690134646	NA	NA	0.844343871162121	0.871105594639364	0.788915825431647	NA	p.Phe21=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	NA	NA	NA	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F21G	21	F	G	missense	wt-like	0.909542784017808	0.0626452247916101	8	0.0221484316295516	0.86613265570984	0.952952912325777	0.919471571856228	0.950022195358712	0.910556330297982	0.949477824243955	0.910179752307381	0.764382796782852	0.90737855957239	0.964873241722966	0.742606036320108	0.744575698822445	0.746167767022826	0.740636373817771	0.712092243913616	0.720115772589532	0.66808514342978	0.776295369303452	0.778775253730113	p.Phe21Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.391	-3.936	2.545	6.068	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21H	21	F	H	missense	wt-like	1.01792928524275	0.163761689910321	4	0.0818808449551607	0.857445778106925	1.17841279237857	0.941448085061781	NA	1.00739697384417	1.24946222814968	NA	NA	NA	0.873409853915364	0.771581856835568	0.755031607772054	NA	0.788132105899082	0.843650866584403	NA	NA	NA	0.732837944920251	p.Phe21His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.391	-3.688	2.297	7.379	7.379	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.58	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21I	21	F	I	missense	wt-like	0.945651605640987	0.142451238874693	4	0.0712256194373466	0.806051956767232	1.08525125451474	NA	0.966630294377485	0.969207413033118	1.09498043016444	NA	NA	NA	0.751788284988908	0.761612881463659	NA	0.753823821163499	0.769401941763819	0.775902635989615	NA	NA	NA	0.671753748241828	p.Phe21Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.391	-2.758	1.367	8.692	8.692	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.58	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F21K	21	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe21Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.391	-3.423	2.032	5.706	5.706	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.86	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21L	21	F	L	missense	wt-like	0.850183358599965	0.11952473772736	7	0.0451761045066877	0.76163982080504	0.938726896394891	1.04868841553468	0.886872104391799	0.806231119166693	0.804773122967233	0.941777418022514	0.684577765341974	NA	0.778363564774864	0.689469817134833	0.806054038885802	0.717056637875259	0.689469817134833	0.648631774148875	0.731918695998642	0.628751422909296	NA	0.685101130877642	p.Phe21Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.391	-2.572	1.181	10.436	10.436	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	neutral	neutral	medium	2.11	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F21M	21	F	M	missense	possibly_wt-like	0.732493299950831	0.234437380085464	6	0.0957086596407174	0.544907774046422	0.920078825855239	NA	0.805574447323009	0.877907004795298	0.899809221613662	0.382247133508564	0.494462260880142	NA	0.934959731584308	0.684944893925393	NA	0.679579786170262	0.72462343173141	0.690310001680525	0.522912969033404	0.535048682817619	NA	0.76375125138595	p.Phe21Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.391	-3.7	2.309	3.014	3.014	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F21N	21	F	N	missense	possibly_wt-like	0.817236933810671	0.481953258958985	7	0.182161209537513	0.460207523736892	1.17426634388445	0.721747186784369	0.806799406591898	0.672873624004024	0.852111485638381	1.65945922740996	0.0260221283510846	0.981645477894978	NA	0.669392086056502	0.650503079199303	0.680144471777695	0.624064305261503	0.669392086056502	1	0.304167334601788	0.816295040822164	NA	p.Phe21Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.391	-4.311	2.92	4.98	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21P	21	F	P	missense	wt-like	0.918821223329698	0.164662536214863	8	0.0582169979824526	0.80471800399605	1.03292444266335	0.981232708517535	1.05141014944198	1.01610525709523	1.02356337614646	0.943453077026039	0.536928072436175	0.880960937847246	0.916916208126923	0.758377969787567	0.773960197423972	0.79290590754066	0.792403104862274	0.744582576881596	0.732544618022652	0.555978921591574	0.76206701278647	0.754688926788665	p.Phe21Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.391	-4.483	3.092	2.637	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F21Q	21	F	Q	missense	wt-like	0.892204321918575	0.102707861434092	7	0.0388199227208412	0.816118671503098	0.968289972334052	NA	0.921629972921005	0.863378029581906	1.0246300322559	1.02025665612943	0.777915602995283	0.775064891539365	0.862555068007136	0.727386149789066	NA	0.733079430307625	0.7174976600628	0.745050360562332	0.761233660114412	0.674755094030726	0.705032101912064	0.727386149789066	p.Phe21Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.391	-4.46	3.069	2.996	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F21R	21	F	R	missense	wt-like	0.847405374180905	0.0645478534679768	8	0.022821112449121	0.802676815693489	0.892133932668321	0.804716523608186	0.924345988609481	0.799084795379323	0.904227603633133	0.882104069869395	0.73847741337942	0.829272421202048	0.897014177766254	0.700938066543743	0.689977941445427	0.734331467830666	0.685964885036676	0.692247689924803	0.709628443162683	0.655317087426676	0.734227919233175	0.744693170710348	p.Phe21Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.391	-4.35	2.959	3.586	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F21S	21	F	S	missense	wt-like	0.869351585153346	0.104963728217116	8	0.0371102820004722	0.796616768976295	0.942086401330396	0.87405709218141	0.66002490101571	0.929775685405434	1.02095337280736	0.812717370131478	0.924489380590058	0.852565437889261	0.880229441206049	0.739850512640495	0.72296855577694	0.61248389485727	0.750062553854707	0.743437955894684	0.683709886076823	0.746997306074909	0.746773384121342	0.736263069386305	p.Phe21Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.391	-3.133	1.742	19.919	19.919	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.355	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F21T	21	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe21Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.391	-3.309	1.918	7.439	6.956	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F21V	21	F	V	missense	wt-like	0.891427732814566	0.220340000162753	8	0.0779019541408638	0.738742708373182	1.04411275725595	0.918690319699404	1.02212239637937	1.03135048832831	1.06105352934842	0.833231994630403	0.377649916886795	0.922910295798926	0.964412921444901	0.769784000056631	0.744203997390919	0.779404746278764	0.799880166059401	0.761023941348389	0.691372874346603	0.477475068610339	0.784660659815146	0.778544058764873	p.Phe21Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.391	-2.682	1.291	6.614	6.614	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
F21W	21	F	W	missense	wt-like	0.954272460002629	0.108889199920383	7	0.0411562490643041	0.873607694097832	1.03493722590742	0.871545788752025	0.917069959769334	0.844135721536828	1.0828184015506	0.914582747560216	1.13144628862446	NA	0.918308312224939	0.730977340987715	0.721773736573508	0.730977340987715	0.708060222701087	0.770568959596816	0.721760457871299	0.849000714048496	NA	0.755388108366987	p.Phe21Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.391	-4.96	3.569	1.412	NA	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.86	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F21X	21	F	X	nonsense	low	0.408882730087523	0.0204615552874619	2	0.0144685044973878	0.380524982362487	0.437240477812559	NA	NA	NA	NA	NA	0.423351234584911	NA	0.394414225590135	0.496131660649439	NA	NA	NA	NA	NA	0.5	NA	0.492263321298877	p.Phe21Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F21Y	21	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe21Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.4	110.7	21	0.356	109.4	-98.9	-117.1	-105.4	36.8421052631579	-0.3	0	0	67.95	0	0	0	0	4	23.6190448126083	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.391	-1.79	0.399	16.303	16.303	90.57	0.003257152	0	0.093094819	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.285	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D22A	22	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp22Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.171	-3.541	2.37	9.895	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D22C	22	D	C	missense	possibly_wt-like	0.802920605967439	0.150504832356176	2	0.106422987560397	0.594335383221907	1.01150582871297	0.909343593527835	NA	NA	NA	NA	NA	NA	0.696497618407042	0.691870581466514	0.739757044550277	NA	NA	NA	NA	NA	NA	0.643984118382752	p.Asp22Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.171	-5.355	4.184	1.651	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D22D	22	D	D	synonymous	wt-like	0.940769578465743	0.243877978076422	6	0.0995627676314826	0.745630139706907	1.13590901722458	NA	0.614021681847537	0.979672150867937	0.716758711483223	1.22231437211488	NA	0.92721099366726	1.18463956081362	0.780755692737217	NA	0.591277185034633	0.774534398202594	0.610032918344174	0.836709860397586	NA	0.786976987271839	0.889152460479881	p.Asp22=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D22E	22	D	E	missense	possibly_wt-like	0.750652142482228	0.0667673573335597	8	0.0236058255662327	0.704385574547077	0.796918710417379	0.871929692883191	0.783094949696754	0.711088081784038	0.657827839570345	0.771001139637618	0.704023274658794	0.716642247308364	0.78960991431872	0.668672206023109	0.721956389144609	0.669217116084589	0.6428066801765	0.584188693642135	0.668127295961629	0.638335583394376	0.67356605173419	0.690749588084	p.Asp22Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.171	-2.609	1.438	8.993	8.993	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.22	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
D22F	22	D	F	missense	possibly_low	0.649764409615123	0.134565348813531	7	0.0508609211496092	0.550078835941357	0.749449983288888	0.879061534716882	0.738982893715304	0.525993100307786	0.661136714115893	0.594269286770231	0.478959954927219	NA	0.669947382752544	0.602111263570194	0.7253495520253	0.648882200663588	0.552026390745661	0.585639805673744	0.602111263570194	0.527408019581655	NA	0.630649314113301	p.Asp22Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.171	-3.516	2.345	33.476	33.476	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D22G	22	D	G	missense	wt-like	0.92056085781108	0.0585907221349163	8	0.020714948468108	0.879960304871985	0.961161410750175	0.979923633562191	0.914577417934078	0.869362231541211	1.00170390148445	0.859913409600555	0.877468942836047	0.87822605718978	0.983311268340325	0.732412195864326	0.773337370298793	0.729828321150042	0.72043262664885	0.734996070578609	0.701339392132395	0.723822216434887	0.760594024134021	0.788035716772961	p.Asp22Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-0.743	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.171	-3.415	2.244	6.068	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.95	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
D22H	22	D	H	missense	possibly_wt-like	0.837734617878385	0.379052427636479	8	0.134015271003489	0.575069513333172	1.1003997224236	1.01356027659028	0.989837730329065	0.991845216411682	1.06557060258861	0.256551104610345	1.30380279702829	0.27184734143164	0.808861874037159	0.763763484672941	0.789340895224821	0.764522058566265	0.780504708172687	0.763004910779617	0.475960747458236	0.933950529981658	0.434002454238665	0.700418847445367	p.Asp22His	1	0	NA	NA	NA	NA	NA	NA	NA	1.66	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.171	-4.619	3.448	1.749	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 4, 2017)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D22I	22	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp22Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.171	-4.196	3.025	10.394	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D22K	22	D	K	missense	wt-like	0.866245236856464	0.153560960212212	7	0.0580405874013996	0.752487775908172	0.980002697804757	NA	0.793050725146413	0.786767879109812	0.690643868063699	1.16397044647633	0.794796104768141	0.92104474015589	0.913442894274969	0.683075032347787	NA	0.673806561015572	0.679924023123923	0.598580213514174	0.814916197159706	0.683075032347787	0.783655883871742	0.752944461655289	p.Asp22Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.171	-3.678	2.507	4.909	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.605	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D22L	22	D	L	missense	low	0.448036271076526	0.312836402302893	6	0.127714926435022	0.197719614975702	0.698352927177351	0.785661309883558	0.526200087722383	0.33432618373476	0.332909387780439	NA	-0.0489078467353857	NA	0.758028504073402	0.504407893852969	0.680911918193399	0.550792908141634	0.458022879564304	0.441695205843222	NA	0.267236396220522	NA	0.674887886152055	p.Asp22Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.171	-3.026	1.855	33.918	33.918	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D22M	22	D	M	missense	possibly_low	0.40590615119505	0.480558729266003	5	0.21491239716394	-0.0153144070774409	0.827126709467541	NA	0.782493879554571	0.405261169980749	0.280046521953428	-0.325277555581928	NA	NA	0.88700674006843	0.492813118234333	NA	0.668940032864788	0.492813118234333	0.418512114562191	0.258625733682651	NA	NA	0.739666954571411	p.Asp22Met	0	0	NA	NA	NA	NA	NA	NA	NA	0.169	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.171	-5.019	3.848	4.501	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D22N	22	D	N	missense	wt-like	1.36050291199857	0.0213019011957825	2	0.0150627187877036	1.33098052566541	1.39002529833172	NA	NA	1.37556563078627	1.34544019321086	NA	NA	NA	NA	0.927221740667342	NA	NA	0.968701330250829	0.885742151083855	NA	NA	NA	NA	p.Asp22Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.171	-1.571	0.4	14.304	14.304	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	0.83	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D22P	22	D	P	missense	wt-like	1.00009877925043	0.319133850928244	5	0.142720996919367	0.720370765450817	1.27982679305004	1.31773491477023	1.07794161315065	0.979460984630399	1.15161370645911	NA	NA	NA	0.473742677241758	0.800739246592221	0.934060045703447	0.805136465797525	0.774430831201432	0.800739246592221	NA	NA	NA	0.532105882002996	p.Asp22Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.171	-4.085	2.914	2.637	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D22Q	22	D	Q	missense	possibly_wt-like	0.820462500023334	0.17586722649766	6	0.0717974945662909	0.679741996493193	0.961183003553474	NA	0.807429350906407	0.934131972914648	1.01233624787071	0.8983730192984	NA	0.512646120856128	0.757858288293713	0.69807018834753	NA	0.680434865504999	0.75219910579024	0.739658902472943	0.715705511190062	NA	0.563695085852233	0.674802395607441	p.Asp22Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.171	-3.998	2.827	2.996	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.525	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D22R	22	D	R	missense	wt-like	0.765887483395796	0.0509026226653336	8	0.0179967948334187	0.730614413685139	0.801160553106453	0.727850454773167	0.734923726133571	0.794175864060487	0.806572797157739	0.6945333266007	0.724720547555196	0.813308249998818	0.831014900886688	0.651413947417736	0.653406870796681	0.64701099272241	0.683557287583921	0.649421024038791	0.639563675196926	0.648536703962149	0.72562972210018	0.71154516213645	p.Asp22Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.171	-4.056	2.885	3.586	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D22S	22	D	S	missense	wt-like	0.942406270438219	0.0623570388485087	8	0.0220465425122468	0.899195841130584	0.985616699745854	0.964659732198654	0.964106009629656	0.933198035912301	1.07129790228496	0.936313642934019	0.863866395461092	0.892217622850662	0.913590822234411	0.752839463281419	0.766075164443833	0.752660168377348	0.751741054087773	0.765516626888401	0.729877769321479	0.717117892319565	0.768129788955133	0.75301875818549	p.Asp22Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.171	-2.672	1.501	19.919	19.919	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.46	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D22T	22	D	T	missense	possibly_wt-like	0.712548272707605	0.22071896936367	7	0.0834239289386793	0.549040376538965	0.876056168876246	NA	0.354118836949329	0.833440610135234	0.46279788489431	0.744807482569044	0.7585804985196	0.912529680965977	0.921562914919745	0.665225349076684	NA	0.471466347586815	0.70281477897923	0.498658006437515	0.658342974202797	0.665225349076684	0.779069729252003	0.757022726246649	p.Asp22Thr	0	0	NA	NA	NA	NA	NA	NA	NA	-1.187	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.171	-3.644	2.473	7.439	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.605	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D22V	22	D	V	missense	possibly_low	0.674536209749373	0.0890950643960715	8	0.0314998621023571	0.612797614510775	0.736274804987971	0.797884078196633	0.754778998199707	0.654187121082814	0.66363948508788	0.575615048244754	0.534732113300688	0.677351044948719	0.738101788933786	0.633651766818011	0.686727224352221	0.656163938989426	0.61489946389137	0.586737399740796	0.595143199835472	0.554896593305373	0.652404069744653	0.664879732191476	p.Asp22Val	1	0	NA	NA	NA	NA	NA	NA	NA	4.423	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.171	-3.963	2.792	8.656	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	3.155	Deleterious	DAMAGING	effect	DAMAGING	null	N	D	D	D	D	D	0.785714285714286
D22W	22	D	W	missense	possibly_wt-like	0.839372799229057	0.206461866850247	6	0.0842877041875912	0.674171934681813	1.0045736637763	NA	1.05137142610277	0.689852230086405	0.839430742919318	1.12761054554966	0.688790976350274	0.639180874365911	NA	0.648111215607516	NA	0.792888056732983	0.632391504421619	0.663830926793413	0.801334398755062	0.630827999552424	0.631845868063337	NA	p.Asp22Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.171	-5.752	4.581	1.555	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D22X	22	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp22Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D22Y	22	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp22Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	107.2	20	0.012	62.8	144	173.6	61.3	55.6149732620321	-0.7	0	0	61.8	1	3	0	0	5	20.7004303786177	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.171	-4.503	3.332	7.764	NA	90.32	0.00308689	0	0.08822845	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L23A	23	L	A	missense	low	0.544636141178215	0.215301549310991	7	0.0813763366233989	0.385141452202546	0.704130830153885	0.808336917099984	0.55381571722503	0.638811140203472	0.655398930800833	0.362365683773657	0.16183877223796	NA	0.63188582690657	0.583123491957816	0.691700439657857	0.563523248583489	0.607358276208284	0.583123491957816	0.51548649548948	0.371107649218846	NA	0.611532971644572	p.Leu23Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-0.689	-3.283	2.594	1.239	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23C	23	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu23Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-0.689	-4.843	4.154	0.348	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23D	23	L	D	missense	low	0.316921860788886	0.326617927188954	7	0.123449972725339	0.0749643603547691	0.558879361223003	NA	0.167423495631961	0.126336339553957	0.0235723789277586	0.68102462383583	0.243193178377601	0.102124231750222	0.874778777444873	0.385402937239766	NA	0.385402937239766	0.3560137483452	0.306034983858652	0.634517663712165	0.411205014214902	0.342590708743817	0.733525484103082	p.Leu23Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-0.689	-4.311	3.622	0.429	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23E	23	L	E	missense	possibly_low	0.525456389242877	0.28523725634994	8	0.100846599106044	0.327800687031681	0.723112091454072	0.278779113469708	0.459156717042228	0.606669534483901	0.885883267027755	0.727762376738692	0.770036021059397	0.0125170424544316	0.462847041666901	0.559113958372922	0.439749271311717	0.519887042568444	0.591594346539726	0.684202752834103	0.651975982399365	0.670871463286041	0.294328868633824	0.526633570206119	p.Leu23Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-0.689	-4.071	3.382	0.627	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.615	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23F	23	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu23Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-0.689	-2.993	2.304	7.939	7.939	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L23G	23	L	G	missense	possibly_low	0.671958382848102	0.128582426731607	8	0.0454607529416708	0.582856944372354	0.76105982132385	0.803314012857128	0.801181195168	0.58607930936597	0.772184149681028	0.567719394082231	0.448671332048602	0.664684100893767	0.731833568688092	0.639960783528221	0.689310659762626	0.677554570863298	0.581495819930609	0.63433982968787	0.592193874331961	0.512479584547574	0.645581737368571	0.661731530752443	p.Leu23Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-0.689	-3.975	3.286	0.677	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23H	23	L	H	missense	possibly_low	0.587617643356906	0.248271722266575	8	0.0877773091957791	0.415577278673342	0.759658008040469	0.299011899928628	0.55323387345614	0.787702168819762	0.401947493359395	0.968361824199105	0.323412769774279	0.823778288135722	0.543492829182214	0.565196394343176	0.449375556019971	0.563255028398205	0.680382247812702	0.471971973446855	0.741848977330428	0.450743060015961	0.731268815464004	0.567137760288148	p.Leu23His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-0.689	-5.055	4.366	0.353	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23I	23	L	I	missense	possibly_wt-like	1.31262379634751	0.490499370520028	2	0.346835431062445	0.632838842902697	1.99240874979233	NA	NA	NA	NA	1.65945922740996	0.965788365285069	NA	NA	0.883676223877564	NA	NA	NA	NA	1	0.767352447755127	NA	NA	p.Leu23Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-0.689	-3.111	2.422	2.316	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.99	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L23K	23	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu23Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-0.689	-3.874	3.185	0.839	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23L	23	L	L	synonymous	wt-like	0.903354060663581	0.163171995933665	6	0.0666146883914953	0.772791670574892	1.03391645075227	NA	1.05152431550469	0.904186656481736	0.858379793763276	0.904516990031648	NA	0.623147101229368	1.07836950697076	0.727756434140523	NA	0.792958536174205	0.737512351610324	0.672141062245432	0.718000516670723	NA	0.623210183788927	0.835778532423674	p.Leu23=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L23M	23	L	M	missense	wt-like	0.860849976984038	0.15717933981265	6	0.0641681967747531	0.735082622352642	0.986617331615433	NA	1.02510774266249	0.918989452088142	0.606991641471677	0.901101840426236	0.740129603176537	NA	0.972779582079144	0.730748624135521	NA	0.780780940673222	0.744772419164924	0.561894400616882	0.716724829106118	0.656131406656345	NA	0.782746197811712	p.Leu23Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-0.689	-3.136	2.447	3.738	3.738	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.415	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L23N	23	L	N	missense	possibly_low	0.688573747533759	0.172899455117136	3	0.0998235469546182	0.492923190693664	0.884224304373853	0.541710562537886	NA	0.644883073790585	0.879127606272806	NA	NA	NA	NA	0.610336270987217	0.564845880848081	NA	0.610336270987217	0.681240047398151	NA	NA	NA	NA	p.Leu23Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-0.689	-4.304	3.615	0.489	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23P	23	L	P	missense	possibly_wt-like	0.74321358433568	0.368444330007666	6	0.150416767856733	0.448402136665561	1.0380250320058	1.04116954572479	0.403755441493394	0.625177103669513	0.34158502250841	1.29030619882605	NA	NA	0.757288193791923	0.637593748085136	0.802476737181896	0.494347986919466	0.600671429418641	0.445499918824119	0.862107379643226	NA	NA	0.67451606675163	p.Leu23Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-0.689	-4.296	3.607	0.377	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23Q	23	L	Q	missense	possibly_low	0.561107598223781	0.20856772188544	6	0.0851474159056733	0.394221729672008	0.727993466775553	0.626293304919566	0.434925093269128	0.619950637771815	0.504083886125242	NA	NA	0.283396741554294	0.897995925702639	0.557436071128701	0.605088363574034	0.508716671816586	0.598108096349806	0.516764045907596	NA	NA	0.440222884836549	0.745186251703828	p.Leu23Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-0.689	-4.299	3.61	0.683	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23R	23	L	R	missense	low	0.582188246847121	0.127674732595917	5	0.0570978762187158	0.470278465864712	0.69409802782953	NA	0.625442253868156	0.411547228193486	0.489901159958024	0.720032632790473	NA	NA	0.664017959425465	0.596541876532948	NA	0.596541876532948	0.49589613096315	0.510544189488451	0.649088630636885	NA	NA	0.627671272768349	p.Leu23Arg	0	0	NA	NA	NA	NA	NA	NA	NA	9.243	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-0.689	-4.125	3.436	0.742	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23S	23	L	S	missense	possibly_low	0.682710016994181	0.478205415751675	6	0.195226543471182	0.30007302296442	1.06534701102394	0.566156567501216	0.261279772721383	0.470523106295333	0.581084882971296	1.62536943565158	NA	NA	0.591846336824272	0.563504833869216	0.576476715989558	0.428669101418239	0.524820995596557	0.550532951748874	0.987266173242541	NA	NA	0.591423215548843	p.Leu23Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-0.689	-3.791	3.102	0.79	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L23T	23	L	T	missense	possibly_low	0.695732008606155	0.126998939056437	4	0.0634994695282184	0.571275335293449	0.820188681918862	NA	0.595628996064978	0.58301353399487	0.763325029239285	0.840960475125488	NA	NA	NA	0.606626557597036	NA	0.582798466429663	0.579992202850888	0.630454648764409	0.694259754161544	NA	NA	NA	p.Leu23Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-0.689	-3.627	2.938	0.932	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23V	23	L	V	missense	possibly_low	0.693521502434849	0.186534026201343	7	0.0705032349114798	0.555337701214781	0.831705303654916	0.769720103883241	0.898915059869438	0.760227945499722	0.780052819381277	0.34851930532179	NA	0.535076867929587	0.762138415158885	0.666907447334653	0.673327466696144	0.722608237672822	0.666907447334653	0.63779064691216	0.510314349362158	NA	0.575776138023544	0.676952081009041	p.Leu23Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-0.689	-3.068	2.379	2.135	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	1	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.27	Neutral	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.857142857142857
L23W	23	L	W	missense	possibly_wt-like	0.865581981908493	0.338832122685856	3	0.195624817242771	0.482164385630432	1.24899957818655	NA	1.20222415188421	NA	NA	NA	0.524601566418821	NA	0.869920227422451	0.73108528679465	NA	0.862428624533377	NA	NA	NA	0.549903523412703	NA	0.73108528679465	p.Leu23Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-0.689	-5.227	4.538	0.369	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L23X	23	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu23Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L23Y	23	L	Y	missense	possibly_wt-like	0.709838041206644	0.134549037444923	8	0.047570268389714	0.6166020284279	0.803074053985387	0.910555466209386	0.534761886577629	0.741757138637784	0.695947213180034	0.758961172459554	0.788702069918773	0.499094625178403	0.748924757491588	0.660739153702609	0.740333625116006	0.554739753322604	0.657848394627905	0.600906003688493	0.663629912777313	0.680071448998725	0.556396339816458	0.670315547120232	p.Leu23Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.6	104.5	21.3	0.862	55.5	-114.6	-117.3	148.8	5.23560209424084	-5.7	0	0	53.8	0	0	0	0	5	17.3648299116346	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-0.689	-4.055	3.366	1.841	NA	18.61	0.001057642	0	0.030229182	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24A	24	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-0.749	-3.472	2.723	5.933	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D24C	24	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-0.749	-5.29	4.541	1.593	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24E	24	D	E	missense	possibly_wt-like	0.82740114356139	0.187980972222724	7	0.0710501291019241	0.688145449424698	0.966656837698083	1.0724665970037	0.887870756617734	0.85013021529563	1.01573986434675	0.547190601984744	0.763337826075755	0.655072143605419	NA	0.711000236925542	0.817367139289944	0.717516999744539	0.711000236925542	0.741151563724188	0.584525593928192	0.667570105906419	0.640404800680344	NA	p.Asp24Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-0.749	-2.63	1.881	21.45	21.45	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	high	3.67	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D24F	24	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-0.749	-4.495	3.746	3.016	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24G	24	D	G	missense	wt-like	0.874868539085298	0.0699625756048169	8	0.0247355058197213	0.826387838539263	0.923349239631332	0.973647088151503	0.935872830141318	0.826785041805773	0.873622291653152	0.83755010669814	0.754992314338731	0.92666176986916	0.869816870024605	0.715291957423109	0.770351137372831	0.739645147785184	0.699550539103809	0.678825683186875	0.692985852547807	0.663456831087303	0.786681178962966	0.731033375742409	p.Asp24Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-0.132	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-0.749	-3.38	2.631	5.784	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Oct 25, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	6	0	2	1	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D24H	24	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-0.749	-4.663	3.914	2.893	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Aug 15, 2014)	criteria provided, single submitter	1	0	0	0	0	3	1	1	1	0	0	1	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D24I	24	D	I	missense	possibly_low	0.379687125124571	0.268985729189893	2	0.190201633152582	0.00689877434481173	0.752475475904331	NA	NA	NA	NA	NA	0.18948549197199	NA	0.569888758277153	0.48256451336563	NA	NA	NA	NA	NA	0.384733962343377	NA	0.580395064387883	p.Asp24Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-0.749	-4.099	3.35	14.015	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24K	24	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-0.749	-3.647	2.898	5.494	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D24L	24	D	L	missense	low	0.475743791732349	0.152484638443789	6	0.0622515929666772	0.353732911537415	0.597754671927283	0.432218247137094	0.271981287961494	0.432395685936461	NA	0.739254834061479	0.513381026046797	NA	0.465231669250769	0.52029162648076	0.512752008184817	0.433602319842148	0.506121308399075	NA	0.656268849941741	0.544373225496475	NA	0.527831244776703	p.Asp24Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-0.749	-3.898	3.149	11.096	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24M	24	D	M	missense	possibly_low	0.429436416543129	0.296216142732809	4	0.148108071366405	0.139149930845287	0.71972290224097	0.606219183248372	0.547811575763231	0.577160758763356	NA	NA	-0.0134458516024456	NA	NA	0.568938567621877	0.595537567846149	0.560755440416653	0.5771216948271	NA	NA	0.284714645153876	NA	NA	p.Asp24Met	0	0	NA	NA	NA	NA	NA	NA	NA	-0.439	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-0.749	-5.046	4.297	2.707	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24N	24	D	N	missense	wt-like	0.849291645696078	0.0584775170091303	4	0.0292387585045651	0.791984732074466	0.90659855931769	NA	0.918702324410167	0.822917483780827	0.784073556854833	NA	NA	NA	0.871473217738485	0.714691759681207	NA	0.731729833615162	0.697653685747252	0.639553947527975	NA	NA	NA	0.731865273163364	p.Asp24Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-0.749	-2.882	2.133	28.607	28.607	90.32	0.001017109	0	0.029070671	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: May 20, 2014)	criteria provided, single submitter	0	1	0	0	0	5	0	0	4	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	high	3.67	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D24P	24	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-0.749	-3.03	2.281	42.967	42.967	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.67	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24Q	24	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-0.749	-3.895	3.146	4.705	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24R	24	D	R	missense	possibly_low	0.673782955571218	0.158274686165983	6	0.064615370050967	0.547139157423595	0.800426753718841	0.632629772057877	0.616595716102935	0.525226137796829	0.950364587367238	NA	0.762099152447341	NA	0.555782367655089	0.600283438678739	0.608103105850967	0.59246377150651	0.551650232093643	0.712481135248017	NA	0.666959597503171	NA	0.573310157107153	p.Asp24Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-0.749	-4.108	3.359	4.003	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D24S	24	D	S	missense	possibly_low	0.627967398799404	0.327417696942005	8	0.115759636894087	0.40108267962356	0.854852117975249	1.19114181873988	0.54651889993403	0.821741148981865	0.760365446106471	0.554736200505038	0.033835382775006	0.517024544949036	0.598375748403911	0.591023380117703	0.873830023162471	0.560159538614555	0.697076749448571	0.629156719020185	0.587344160407559	0.308018274327232	0.566053276139936	0.594702599827846	p.Asp24Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-0.749	-3.397	2.648	6.366	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D24T	24	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-0.749	-3.617	2.868	4.524	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D24V	24	D	V	missense	low	0.371202092913657	0.239128669523306	2	0.169089503796046	0.0397927553096575	0.702611430517656	NA	0.202112589117611	0.540291596709703	NA	NA	NA	NA	NA	0.480216574524086	NA	0.401394025534506	0.559039123513666	NA	NA	NA	NA	NA	p.Asp24Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-0.749	-3.087	2.338	22.981	22.981	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D24W	24	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-0.749	-5.743	4.994	0.416	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D24X	24	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp24Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D24Y	24	D	Y	missense	possibly_low	0.647107290268216	0.248179127412646	4	0.124089563706323	0.403896214546534	0.890318365989898	NA	0.346222303987413	0.742869312145246	0.57072914189063	NA	NA	NA	0.928608403049575	0.602192644200398	NA	0.467826178786539	0.658393862863183	0.545991425537612	NA	NA	NA	0.76056130897023	p.Asp24Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	-1.848	32	101	22.7	0.536	75.6	105.4	-80.3	79.4	18.1818181818182	-2.4	0	0	46.47	0	0	1	135	5	13.8319274817359	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-0.749	-4.556	3.807	1.813	NA	90.32	0.001017109	0	0.029070671	0	NA	NA	not provided	Pathogenic(Last reviewed: Jul 13, 2016)	criteria provided, single submitter	1	0	0	0	0	5	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L25A	25	L	A	missense	possibly_low	0.5629445804572	0.175337858973318	4	0.0876689294866591	0.391116636100166	0.734772524814233	NA	0.795755696390572	0.477180231591714	NA	NA	0.389766344364487	0.589076049482024	NA	0.566472869759648	NA	0.675053507235656	0.528085999090238	NA	NA	0.483446924814259	0.604859740429056	NA	p.Leu25Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-0.955	-3.339	2.384	5.964	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.57	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L25C	25	L	C	missense	possibly_low	0.599196176144	0.335235502661989	7	0.126707110097622	0.350854803767509	0.847537548520491	0.722164896513133	0.81163924248508	0.415103924736672	0.532948964400649	0.796113165772651	-0.0404114333364105	NA	0.956814472436226	0.650701815679948	0.650701815679948	0.682375554672148	0.497640521540533	0.529422870472323	0.67750758765126	0.271424046347686	NA	0.774727752514313	p.Leu25Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-0.955	-3.252	2.297	43.653	43.653	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.57	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L25D	25	L	D	missense	low	0.345579706064662	0.23244457193203	6	0.0948950991188556	0.159588729482346	0.531570682646977	0.142172984724579	NA	0.677317080721658	0.448983312606125	0.348346266347913	NA	0.0276639800476756	0.428994611940021	0.501115428810825	0.374755282922476	NA	0.626243609549945	0.492599604469421	0.510249712759762	NA	0.302486909144035	0.509631253152228	p.Leu25Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-0.955	-4.319	3.364	3.042	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25E	25	L	E	missense	low	0.459421107372669	0.185272841906747	8	0.0655038414409821	0.331035937299322	0.587806277446017	0.734619612356352	0.443912827284889	0.428508153047654	0.513865717028806	0.653746618710919	0.136291812717274	0.438293302338209	0.326130815497251	0.516956874432214	0.656627477027221	0.512859865938252	0.504214658321352	0.521053882926176	0.624328296935984	0.358516250558985	0.523649149055868	0.45796811125674	p.Leu25Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-0.955	-4.119	3.164	3.287	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25F	25	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu25Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-0.955	-3.953	2.998	3.828	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	2	0	0	1	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	3.57	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L25G	25	L	G	missense	low	0.358222304187231	0.0958506003821812	8	0.0338883047555211	0.291802447369292	0.424642161005169	0.380008826940846	0.381873224360957	0.428999260466407	0.513649406787257	0.29442200092852	0.210917385341624	0.270906620998461	0.385001707673773	0.487723947228199	0.487911991992168	0.484260653089476	0.50445552316415	0.520959019736365	0.49010695979897	0.395297157279909	0.4334957884288	0.48753590246423	p.Leu25Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-0.955	-4.014	3.059	3.506	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25H	25	L	H	missense	possibly_wt-like	0.746838400428582	0.148754289670577	5	0.066524940729621	0.616451912524863	0.877224888332301	NA	0.987603846125335	0.786744226127635	0.663404429145099	0.683845416495173	NA	0.612594084249667	NA	0.635571336474304	NA	0.763492275543631	0.679912422460573	0.58663431559482	0.635571336474304	NA	0.617526398568623	NA	p.Leu25His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-0.955	-5.144	4.189	1.193	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25I	25	L	I	missense	possibly_low	0.700371691380119	0.253154552426421	5	0.113214157607802	0.478476019928785	0.922267362831453	NA	NA	0.617509538121408	0.488131933008662	0.45943235555598	0.93154679199333	NA	1.00523783822121	0.59691085301546	NA	NA	0.59691085301546	0.509768292283064	0.551744569201404	0.75047571141756	NA	0.799048293891559	p.Leu25Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-0.955	-2.555	1.6	23.178	23.178	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.875	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L25K	25	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu25Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-0.955	-3.946	2.991	3.764	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25L	25	L	L	synonymous	possibly_wt-like	0.921993202683704	0.313875179078394	8	0.110971633786237	0.70449279715711	1.1394936082103	1.14497746139138	0.913346682791254	0.930749095223202	1.209093791023	0.919226246019979	0.199723993764673	0.950154337703897	1.10867401355225	0.774937042938712	0.851866105927812	0.729260972961929	0.750539965096692	0.825947226266396	0.723494980198518	0.389780240263338	0.799334120780733	0.850998911971528	p.Leu25=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L25M	25	L	M	missense	wt-like	1.00565117196936	0.162209057463316	7	0.0613092609214456	0.885487228644558	1.12581511529416	1.02049699128381	1.05131065273222	1.01908101253104	1.26595235501868	0.99018015421295	NA	0.981515338497324	0.711021699509499	0.792860041231944	0.792641221194027	0.792860041231944	0.793862571443076	0.850882637137495	0.749998948926108	NA	0.816224948602433	0.651278809895672	p.Leu25Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-0.955	-2.191	1.236	6.431	6.431	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.155	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L25N	25	L	N	missense	possibly_low	0.523468650749743	0.2891339587199	3	0.166931568898797	0.196288787825336	0.850648513674151	NA	0.304130695614175	0.415154619432084	0.851120637202972	NA	NA	NA	NA	0.497665384878725	NA	0.448422655709682	0.497665384878725	0.668957547948051	NA	NA	NA	NA	p.Leu25Asn	0	0	NA	NA	NA	NA	NA	NA	NA	5.117	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-0.955	-4.337	3.382	3.587	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25P	25	L	P	missense	low	0.463589461226518	0.202715974111103	8	0.0716709199743988	0.323117039337844	0.604061883115192	0.77549006913803	0.153952336061538	0.275799340577319	0.378359871815962	0.464645136534846	0.485367710672953	0.485663734925989	0.689437490085505	0.539864389229357	0.676072680679009	0.379192959391476	0.429318245225055	0.461627585665585	0.553691740084111	0.530566227392812	0.549162551065901	0.640438182651332	p.Leu25Pro	0	0	NA	NA	NA	NA	NA	NA	NA	23.975	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-0.955	-4.323	3.368	2.167	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25Q	25	L	Q	missense	possibly_low	0.552510144905389	0.223606274806027	8	0.0790567566156022	0.39756174920426	0.707458540606518	0.782367063738311	0.275024365408178	0.451705883459813	0.566950864462411	0.803038571541378	0.75468621267426	0.226769882802761	0.559538315155998	0.559765515294955	0.679344593230146	0.435005127331418	0.515592042322574	0.54433445614836	0.680094488677501	0.663305961936527	0.40972403285296	0.575196574441549	p.Leu25Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-0.955	-4.332	3.377	2.213	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25R	25	L	R	missense	low	0.361511736170458	0.136800595992476	8	0.0483663145483203	0.266715501590814	0.456307970750101	0.413860996050227	0.369395281734555	0.506023694562975	0.545451506754084	0.22531488948284	0.12750795174316	0.351151457371431	0.353388111664387	0.477611829324826	0.504018059166875	0.478508531536976	0.542232346526756	0.534905879690423	0.46429283951642	0.354186925372232	0.476715127112675	0.47165803529482	p.Leu25Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-0.955	-4.204	3.249	2.856	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L25S	25	L	S	missense	low	0.501896280800665	0.128318099359207	8	0.0453672991029323	0.412978008483061	0.590814553118268	0.379887318678881	0.58390212210812	0.52629193752098	0.492241998701321	0.3667073733575	0.456638137672944	0.765182673401092	0.444318684964477	0.517218009919196	0.487854181214278	0.577392574893669	0.552172956192709	0.511570767927041	0.517108280784832	0.51640620546622	0.699709604515711	0.51732773905356	p.Leu25Ser	1	0	NA	NA	NA	NA	NA	NA	NA	3.444	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-0.955	-3.811	2.856	7.54	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jul 1, 2014)	criteria provided, single submitter	0	0	1	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L25T	25	L	T	missense	low	0.634034574544365	0.0867893472184372	7	0.0328032898842315	0.569741307796844	0.698327841291885	NA	0.616411323790181	0.707728632185062	0.766319106586684	0.537017524025235	0.538696224744566	0.594537346608742	0.677531863870084	0.607801158978106	NA	0.592378769753572	0.641159029848592	0.631767705999603	0.580725564486982	0.556850395576111	0.607801158978106	0.634458605017678	p.Leu25Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-0.955	-3.082	2.127	20.076	20.076	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L25V	25	L	V	missense	wt-like	0.878853965821718	0.105553634829821	8	0.0373188454835276	0.805710372729388	0.951997558914047	0.921649460401377	1.00831559419289	0.824250678932441	1.01148346605408	0.781549056496433	0.73827352112914	0.803665279287728	0.941644670079654	0.72986049774016	0.74561188705292	0.773040042833188	0.698307554592133	0.739284913692948	0.672067341910993	0.655216594504814	0.720436081787372	0.767108748756172	p.Leu25Val	1	0	NA	NA	NA	NA	NA	NA	NA	5.012	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-0.955	-2.752	1.797	15.047	8.818	90.32	0.001577658	0	0.045092107	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jul 5, 2013)	criteria provided, single submitter	0	0	1	0	0	0	3	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	3.225	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L25W	25	L	W	missense	low	0.434919228187647	0.16277964186426	7	0.0615249215538559	0.314332597790438	0.555505858584857	0.542692035825243	0.469022480621157	0.420927631562644	0.528666962049559	0.471268193612231	0.0794088120277066	NA	0.532448481614991	0.527544991741803	0.565312842792093	0.52443499354188	0.500496772893247	0.527544991741803	0.556165702437004	0.330480172994784	NA	0.561590758182056	p.Leu25Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-0.955	-5.367	4.412	0.53	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L25X	25	L	X	nonsense	possibly_low	0.658178169349559	0.170041446461815	8	0.0601187299379592	0.540347623874869	0.776008714824249	0.539879667110533	0.601381029115344	0.75782398660966	0.922455098858505	0.562087965630458	0.873527580994433	0.538335416958424	0.469934609519117	0.587770189821694	0.563974783795259	0.585450056861703	0.66572841977767	0.700241386048225	0.590090322781685	0.721879626821812	0.577531171000878	0.530193287388506	p.Leu25Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L25Y	25	L	Y	missense	wt-like	0.934363836071874	0.197813193489374	3	0.11420750051035	0.710521248307249	1.1582064238365	NA	0.705977263542706	NA	NA	NA	1.04543628354714	NA	1.05167796112577	0.806608731480542	NA	0.63366716062422	NA	NA	NA	0.806608731480542	NA	0.822372755385618	p.Leu25Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	101.5	26.2	0.983	47.4	-158.4	-152.9	155.4	0.523560209424084	-3.1	0	1	40.35	0	0	0	0	8	13.9560831847621	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-0.955	-4.25	3.295	1.737	NA	90.32	0.001577658	0	0.045092107	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T26A	26	T	A	missense	wt-like	0.779671300254878	0.10266428119058	8	0.0362973047077509	0.70852989029181	0.850812710217946	0.866764454586636	0.756230421415047	0.731072423302843	0.566666379675362	0.774555948851904	0.814464222085648	0.899285504231116	0.828331047890464	0.681112030955058	0.719498890048794	0.656833020664885	0.652608049682537	0.54420969490655	0.669455151673139	0.692768910236978	0.771936503168363	0.710197202183915	p.Thr26Ala	1	1	NA	0.497947983422629	-0.777969679592596	0.306844168855712	0.689051797989547	NA	NA	2.297	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.381	-2.033	0.652	12.003	12.003	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.705	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T26C	26	T	C	missense	wt-like	0.963216717709902	0.0807017511470238	5	0.0360909202936034	0.892479813765534	1.03395362165427	NA	0.862342282576688	1.02943890237063	1.04719969433329	0.978677160011347	NA	NA	0.898425549257561	0.745702145460909	NA	0.705748802844576	0.798942624019492	0.754948320650881	0.745702145460909	NA	NA	0.745402029299513	p.Thr26Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.381	-3.083	1.702	13.911	13.911	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.175	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26D	26	T	D	missense	possibly_low	0.67014417668323	0.080571109581244	2	0.056972377952622	0.558480367782487	0.781807985583973	NA	NA	NA	NA	0.727116554635852	NA	NA	0.613171798730608	0.626934315384618	NA	NA	NA	NA	0.651734743414041	NA	NA	0.602133887355195	p.Thr26Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.381	-3.896	2.515	6.536	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26E	26	T	E	missense	possibly_low	0.535817658042359	0.371804213071237	2	0.262905280336399	0.0205327772376095	1.05110253884711	NA	NA	NA	NA	0.272912377705959	NA	NA	0.798722938378758	0.588699444289357	NA	NA	NA	NA	0.482072301867478	NA	NA	0.695326586711235	p.Thr26Glu	0	1	NA	NA	NA	NA	NA	NA	NA	4.226	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.381	-3.302	1.921	21.45	21.45	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26F	26	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr26Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.381	-3.579	2.198	34.911	34.911	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26G	26	T	G	missense	low	0.426673190307327	0.122252199802019	8	0.0432226797474903	0.341958294686937	0.511388085927717	0.543816688493789	0.404592935241366	0.464009927817515	0.587706636123589	0.215938077740672	0.439759689616978	0.295368093811631	0.462193473613077	0.514856935272307	0.56584792612366	0.49473405744263	0.521626591174485	0.553436931799301	0.460790245628244	0.508087279370128	0.446670576066287	0.526305316920991	p.Thr26Gly	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.381	-2.933	1.552	13.537	13.537	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26H	26	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr26His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.381	-5.034	3.653	1.817	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T26I	26	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr26Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.381	-3.165	1.784	15.901	15.901	90.32	0.003314919	0	0.094745911	3.227e-05	1	30986	NA	NA	NA	0	0	0	0	0	0	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T26K	26	T	K	missense	possibly_low	0.62595598946623	0.132415456685554	8	0.0468159336781345	0.534198445554471	0.71771353337799	0.841568352899726	0.588913901547624	0.74014204575319	0.671470497193991	0.500207450203126	0.676359822492097	0.435978730168398	0.553007115471692	0.58493731151919	0.707511176499364	0.579702920869242	0.657056268345756	0.590171702169139	0.566975609476921	0.624701023310746	0.522402535777845	0.571916292090452	p.Thr26Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.381	-3.86	2.479	5.494	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26L	26	T	L	missense	low	0.486823664496591	0.0891276161324743	6	0.036386196919202	0.415508029000572	0.558139299992609	0.513155336029726	0.512431215875481	0.446375994743745	0.326599710259168	0.560427267902048	NA	NA	0.561952462169375	0.547852832264518	0.551259974584782	0.544445689944253	0.512977985277808	0.438928087041753	0.58946998935988	NA	NA	0.576409075088248	p.Thr26Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.381	-3.528	2.147	10.343	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26M	26	T	M	missense	possibly_low	0.706704568216981	0.132455101327531	4	0.0662275506637656	0.576900954131699	0.836508182302264	NA	0.809651594039644	0.64190299305184	0.823845259317205	NA	NA	NA	0.551418426459237	0.6329352859951	NA	0.681459282190049	0.608874683050943	0.656995888939257	NA	NA	NA	0.571118376120824	p.Thr26Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.381	-4.836	3.455	2.273	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T26N	26	T	N	missense	low	0.42161733710288	0.0486238485279288	2	0.034382253021486	0.354229359473424	0.489005314732336	0.455999590124366	NA	NA	NA	NA	NA	NA	0.387235084081394	0.506362112095269	0.524066612765106	NA	NA	NA	NA	NA	NA	0.488657611425431	p.Thr26Asn	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.381	-3.957	2.576	4.966	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T26P	26	T	P	missense	low	0.13051033572119	0.078561578584885	3	0.0453575485439453	0.0416111741480304	0.21940949729435	NA	0.191921899486806	0.0419825294303304	NA	NA	NA	NA	0.157626578246435	0.373337185507043	NA	0.396696289119517	0.314642214462747	NA	NA	NA	NA	0.373337185507043	p.Thr26Pro	1	1	NA	NA	NA	NA	NA	NA	NA	12.972	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.381	-4.134	2.753	2.63	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Jan 18, 2016)	criteria provided, single submitter	0	1	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T26Q	26	T	Q	missense	wt-like	0.926178919408689	0.142269133585344	4	0.0711345667926718	0.786757730439193	1.06560010837818	0.930078228153631	1.00009772073541	0.725692489428928	1.04884723931679	NA	NA	NA	NA	0.752646475437483	0.749622096832363	0.769251741472474	0.649969447866877	0.755670854042603	NA	NA	NA	NA	p.Thr26Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.381	-4.288	2.907	4.705	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T26R	26	T	R	missense	possibly_low	0.604193828195795	0.25705566576299	8	0.0908829022017165	0.426066613069954	0.782321043321635	0.940578115306761	0.624178905899058	0.696609746569145	0.881051272245048	0.496152362689958	0.199091000122649	0.317058297441913	0.678830925291826	0.615535275236705	0.754617696590498	0.595959494380783	0.635705745019847	0.682083674075045	0.565460880896441	0.389468254984251	0.458352776431957	0.635111056092627	p.Thr26Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.381	-4.182	2.801	3.581	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T26S	26	T	S	missense	wt-like	1.00302921822502	0.134775830433226	7	0.0509404757240751	0.903187720450496	1.10287071599954	1.10113705166125	0.868432027625763	1.01433165341945	1.12939848417426	0.927156976053291	NA	1.16223422949064	0.818514105150493	0.790996726620951	0.831007868401034	0.708556072824476	0.791533236572283	0.790996726620951	0.726457407866607	NA	0.913558949261512	0.705266661767422	p.Thr26Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.381	-1.896	0.515	19.864	19.864	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	low	0.82	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	B	0.428571428571429
T26T	26	T	T	synonymous	wt-like	1.14513234041245	0.161442329605827	7	0.0610194650308485	1.02553638659609	1.26472829422882	1.11272310734207	1.04324628524527	1.0122991795768	1.10025115431065	1.48367878607687	1.2037174722923	1.06001039804321	NA	0.836520241640167	0.836520241640167	0.789142503540212	0.790536404771522	0.778214120187209	0.93433935580626	0.884621206751158	0.858501869048211	NA	p.Thr26=	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T26V	26	T	V	missense	possibly_low	0.691653112407588	0.282893163580696	8	0.100017837159613	0.495621753763155	0.887684471052021	0.87127677287271	0.806868533124042	0.830284988481424	0.877138305156239	0.58197301293432	0.0367371979300775	0.695600250765621	0.833345837996269	0.680271987136601	0.721645745134929	0.680176337945644	0.701267096568923	0.680367636327557	0.597518140153701	0.309448499768547	0.662232971423092	0.712715870770646	p.Thr26Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.381	-2.831	1.45	10.323	7.616	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.33	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T26W	26	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr26Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.381	-3.912	2.531	43.124	43.124	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T26X	26	T	X	nonsense	possibly_low	0.527925124691835	0.324148904653439	4	0.16207445232672	0.21026503531741	0.845585214066259	0.471063017280391	NA	NA	NA	0.86480460140079	0.105700571847336	NA	0.670132308238821	0.580987815139481	0.531233437699495	NA	NA	NA	0.70316643729193	0.343438663381485	NA	0.630742192579467	p.Thr26Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T26Y	26	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr26Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	101.9	29.7	0.965	19.9	-131.3	-146.3	125.2	1.22699386503067	-7.5	0	1	38.08	1	133	0	0	7	15.3329950714138	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.381	-4.454	3.073	8.097	NA	90.32	0.003314919	0	0.094745911	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y27A	27	Y	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-0.998	-3.511	2.513	6.398	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27C	27	Y	C	missense	low	0.349459352198348	0.140031730799771	5	0.0626240938150478	0.226718383756397	0.472200320640299	NA	0.210811679546544	0.467949937137723	NA	0.229505341724066	0.317123929703206	0.521905872880203	NA	0.465858131943355	NA	0.405404159820389	0.523558978447203	NA	0.465858131943355	0.447643462493255	0.568682327112183	NA	p.Tyr27Cys	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-0.998	-3.281	2.283	35.018	35.018	90.32	0.001276306	0	0.036478963	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Nov 12, 2016)	criteria provided, single submitter	0	0	1	0	0	4	2	0	1	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y27D	27	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Asp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-0.998	-2.949	1.951	35.833	35.833	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	2	2	1	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	3.22	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	.	D	0.714285714285714
Y27E	27	Y	E	missense	possibly_low	0.684512817638745	0.192520428947596	8	0.0680662504128939	0.551105418266788	0.817920217010701	0.941552670815847	0.492025145047398	0.776314482066017	0.798164201681396	0.54495229657964	0.456207314196946	0.562278489957569	0.904607940765145	0.618080086728458	0.755081367218046	0.53503883471768	0.674797128804031	0.645733421533258	0.583689502189618	0.516193864340696	0.590426751923657	0.748507123421598	p.Tyr27Glu	0	1	NA	NA	NA	NA	NA	NA	NA	8.411	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-0.998	-2.921	1.923	8.28	6.266	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y27F	27	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Phe	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-0.998	-2.494	1.496	35.772	35.772	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.33	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y27G	27	Y	G	missense	low	0.274944310704277	0.0587903071898865	4	0.0293951535949433	0.217330868338165	0.332557753070389	NA	0.273361850862316	NA	0.258757560554835	0.213307595565453	NA	NA	0.354350235834504	0.44702319856804	NA	0.434238736105162	NA	0.409175807730151	0.459807661030918	NA	NA	0.472141260289821	p.Tyr27Gly	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-0.998	-3.749	2.751	5.451	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27H	27	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27His	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-0.998	-3.348	2.35	8.521	8.521	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
Y27I	27	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-0.998	-3.903	2.905	5.961	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27K	27	Y	K	missense	low	0.552845894320624	0.171549425655347	6	0.0700347597538532	0.415580287537157	0.690111501104092	0.667940151895077	0.341646340398604	0.343150120709845	0.557657955821454	0.704183754255064	NA	NA	0.702497042843702	0.582580996095549	0.62490295544952	0.465716736583548	0.462350601181221	0.540259036741577	0.643168474978546	NA	NA	0.646997317648976	p.Tyr27Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-0.998	-3.883	2.885	4.652	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27L	27	Y	L	missense	low	0.375397363355835	0.204061432522019	5	0.0912590469410444	0.196532918087938	0.554261808623732	NA	0.150173867572093	0.629826959630192	NA	0.316110726946416	NA	0.236917427626847	0.543957835003627	0.498208519399551	NA	0.3774511490078	0.602951962724058	NA	0.498208519399551	NA	0.41518943344925	0.56737130855843	p.Tyr27Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-0.998	-3.484	2.486	10.598	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27M	27	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-0.998	-4.792	3.794	2.329	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y27N	27	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Asn	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-0.998	-3.243	2.245	26.957	26.957	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.857142857142857
Y27P	27	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-0.998	-4.31	3.312	2.084	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y27Q	27	Y	Q	missense	low	0.314522372777079	0.229375870402572	5	0.102580007723667	0.113469252104852	0.515575493449306	NA	0.22581723505892	0.435673751529102	0.657005712141282	0.139824116756224	NA	0.114291048399866	NA	0.43235880199052	NA	0.412321468374713	0.507729043740681	0.583828148391051	0.43235880199052	NA	0.349143675803797	NA	p.Tyr27Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-0.998	-4.146	3.148	2.918	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.22	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y27R	27	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-0.998	-4.168	3.17	3.772	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y27S	27	Y	S	missense	possibly_low	0.508828959489652	0.364800250661964	6	0.148929078693535	0.216933328999591	0.800724589979713	0.212125274829641	0.213684436723828	0.474352273489158	0.540475137643733	1.20065611094036	NA	NA	0.411680523311189	0.513817152927863	0.408036939994917	0.406728452531881	0.52669902007546	0.532723485347465	0.828619680568418	NA	NA	0.500935285780266	p.Tyr27Ser	1	1	NA	NA	NA	NA	NA	NA	NA	6.37	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-0.998	-3.125	2.127	12.879	12.879	90.32	0.001276306	0	0.036478963	0	NA	NA	not provided	Pathogenic(Last reviewed: Jul 6, 2016)	criteria provided, single submitter	1	0	0	0	0	1	2	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y27T	27	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-0.998	-3.838	2.84	4.81	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27V	27	Y	V	missense	low	0.400731691836378	0.223306715073704	7	0.084402004882254	0.235306802044187	0.56615658162857	NA	0.676645116458444	0.496646582411452	0.447182248335159	-0.0260306625243777	0.317765276076189	0.542682210565773	0.350231071532011	0.491809744957577	NA	0.620145534465475	0.537633318782452	0.491809744957577	0.370405768037561	0.447959564605318	0.579872325318045	0.470072418022572	p.Tyr27Val	0	1	NA	NA	NA	NA	NA	NA	NA	5.79	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-0.998	-3.662	2.664	5.042	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y27W	27	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-0.998	-4.723	3.725	1.662	NA	90.32	0.001276306	0	0.036478963	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y27X	27	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr27Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	32.9	103.4	33	0.634	19.7	-177.1	-73.7	116.7	13.7254901960784	-1	0	1	37.29	0	0	0	0	7	17.7545137320063	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I28A	28	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.075	-3.282	2.207	4.146	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28C	28	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.075	-4.933	3.858	1.472	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28D	28	I	D	missense	low	0.195986826477525	0.148595503546686	6	0.0606638602935515	0.0770878451389949	0.314885807816056	NA	0.0848325730030838	0.375258703232549	0.353647708856777	0.0779065248603787	0.0389144676989792	0.245360981213384	NA	0.414483657422854	NA	0.347329911876657	0.478098334541561	0.450790028513287	0.409230239222251	0.310521616576365	0.419737075623456	NA	p.Ile28Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.075	-4.226	3.151	1.426	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28E	28	I	E	missense	low	0.201342301910482	0.269056429474344	7	0.101693771576015	0.00202617216944984	0.400658431651513	NA	0.336296650048602	0.25143325899973	0.495269920747133	-0.271568055155416	-0.0490649320333659	0.397787111800916	0.249242158965772	0.419350932911107	NA	0.463250619365126	0.417367840517876	0.512898667806885	0.278688263794554	0.267158973167149	0.501832782461412	0.419350932911107	p.Ile28Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.075	-4.094	3.019	1.879	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28F	28	I	F	missense	low	0.365484459764424	0.207436711352869	8	0.0733399526323249	0.221740793977194	0.509228125551655	0.0793822682796678	0.374589179678362	0.507012116402641	0.570381353087975	0.111944023920408	0.431275882106089	0.222595376456427	0.626695478183826	0.492404336709497	0.344880934435616	0.480902831078059	0.542717120451845	0.545838902222193	0.42194453267877	0.503905842340934	0.407475671316255	0.6089261290836	p.Ile28Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.075	-3.992	2.917	5.081	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I28G	28	I	G	missense	low	0.295384072654918	0.150787810724304	8	0.0533115417417146	0.190895370880854	0.399872774428982	0.328127099392265	0.149537023225825	0.280939572584202	0.418629694726211	0.510907061951321	0.0737339105987754	0.41414162564896	0.187056593111784	0.447533584468243	0.463227884266683	0.37715757448198	0.431839284669803	0.47928797856699	0.570972319205724	0.327683169062115	0.510641215563867	0.388118353289634	p.Ile28Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.075	-4.013	2.938	1.958	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28H	28	I	H	missense	low	0.240580916254494	0.423204010326856	4	0.211602005163428	-0.174151392922283	0.655313225431272	NA	0.8749478321735	NA	NA	0.0251808167774971	0.0121275375125006	0.0500674785544805	NA	0.352044239091298	NA	0.711559749062866	NA	NA	0.389535192765217	0.297319070238955	0.31455328541738	NA	p.Ile28His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.075	-5.201	4.126	0.926	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28K	28	I	K	missense	low	0.371956493932936	0.169922906592769	4	0.0849614532963845	0.20543510539784	0.538477882468031	NA	0.165157864642853	0.302190912754938	0.529533571381614	NA	NA	NA	0.490943626952339	0.485093550692227	NA	0.384358519483358	0.442262056784454	0.527925044599999	NA	NA	NA	0.540745025573099	p.Ile28Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.075	-4.098	3.023	2.311	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28L	28	I	L	missense	wt-like	0.812173676225858	0.143983995500378	8	0.0509060298003252	0.712399691221298	0.911947661230418	0.871256426667445	0.657278196046113	0.697092034347444	0.96411252064515	0.722968149969768	1.00998879804194	0.915771614722693	0.65892166936631	0.684347734961216	0.721636064888216	0.61121771009212	0.635942284248268	0.71851031257545	0.650185157346981	0.789137633946443	0.780815813353551	0.625111670988405	p.Ile28Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.075	-2.423	1.348	34.849	34.849	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.535	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I28M	28	I	M	missense	low	0.506604223523752	0.109014530039736	2	0.0770849134389618	0.355520569432	0.657687877615505	NA	0.42951931008479	NA	NA	NA	NA	NA	0.583689136962714	0.546775487256824	NA	0.506224696745553	NA	NA	NA	NA	NA	0.587326277768096	p.Ile28Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.075	-4.312	3.237	4.625	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.335	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I28N	28	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.075	-4.419	3.344	1.285	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I28P	28	I	P	missense	low	0.132481857353196	0.267988172345207	2	0.189496253943085	-0.238923975580507	0.5038876902869	NA	NA	NA	NA	-0.0570143965898889	NA	NA	0.321978111296282	0.407357297481904	NA	NA	NA	NA	0.358832171323158	NA	NA	0.45588242364065	p.Ile28Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.075	-4.309	3.234	1.327	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28Q	28	I	Q	missense	low	0.279772324419931	0.153842531788101	8	0.0543915487311368	0.173166847843547	0.386377800996314	0.134455733232369	0.483429236585426	0.360389490874526	0.419552896239524	0.254481105802848	0.302569429386372	0.00430557687047955	0.2789951263679	0.455637819749161	0.371083595872348	0.531076265582059	0.47080569272759	0.479692850013498	0.475187524600507	0.440469946770731	0.289906227524378	0.434294302977787	p.Ile28Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.075	-4.541	3.466	1.518	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28R	28	I	R	missense	low	0.277164103661491	0.117795921228612	7	0.0445226732898087	0.189901267518023	0.36442693980496	NA	0.282403015985681	0.330377789957324	0.366286822266732	0.31473320083138	0.177421037973998	0.0649841365164486	0.403942722098875	0.456086380113893	NA	0.438406561068212	0.456086380113893	0.456332931178707	0.49769396128705	0.378787722448205	0.322587298839669	0.497048990156196	p.Ile28Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.075	-4.44	3.365	2.27	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28S	28	I	S	missense	low	0.234566174343512	0.185032793749785	7	0.0699358223790626	0.0974944812513591	0.371637867435665	0.409442404269333	0.294545131877805	0.230661714347844	0.337456071137685	-0.11004050763254	NA	0.0953284188988836	0.384569987505574	0.443689160836921	0.5019157969511	0.444003872148026	0.407180385296862	0.443689160836921	0.339024912997121	NA	0.338930528842782	0.4873190718486	p.Ile28Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.075	-3.906	2.831	2.278	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I28T	28	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.075	-3.626	2.551	3.119	NA	92.8	0.002568273	0	0.073405531	4.072e-06	1	245574	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I28V	28	I	V	missense	wt-like	1.0142934153102	0.252871619157475	8	0.0894036183379364	0.839065543280276	1.18952128734012	0.442055429571951	1.13649685484875	1.17327412095195	1.25415519778723	1.00016842042706	1.13688262544734	0.933016202166593	1.0382984712807	0.823891189684595	0.517432308599059	0.832129446761454	0.869486961143163	0.845708975651786	0.75372994418942	0.851680136002046	0.790103634213918	0.815652932607737	p.Ile28Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.836	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.075	-1.34	0.265	10.823	10.823	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I28W	28	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.075	-5.604	4.529	0.687	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I28X	28	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I28Y	28	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile28Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	100.6	35.6	0.765	82.2	-0.8	-80.7	-30.1	4.18848167539267	-3.8	0	1	36.82	0	0	0	0	6	16.9667474154594	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.075	-4.233	3.158	2.073	NA	92.8	0.002568273	0	0.073405531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y29A	29	Y	A	missense	possibly_wt-like	0.787979280275278	0.23479379086633	8	0.0830121408510391	0.625278473927676	0.950680086622881	0.593862396413836	0.867112027757635	0.906569158421084	1.16852054047299	0.697512182896841	0.998774602072878	0.575814806171712	0.495668527995251	0.674311982903433	0.589658498821724	0.707947575100285	0.738680855552994	0.80815376470593	0.64067639070658	0.783610463013168	0.597717322400639	0.543118097941257	p.Tyr29Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.569	-3.122	0.553	7.835	7.835	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29C	29	Y	C	missense	possibly_wt-like	0.728721664905108	0.669638274400067	3	0.386615837984555	-0.0290314533973925	1.48647478320761	NA	0.888457018672053	1.30404776173229	NA	-0.00633978568902115	NA	NA	NA	0.717787256685048	NA	0.717787256685048	0.933625215272367	NA	0.377761055394583	NA	NA	NA	p.Tyr29Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.569	-2.833	0.264	24.105	24.105	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.48	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
Y29D	29	Y	D	missense	low	0.0242108788976218	0.0556051894188094	2	0.0393188065072026	-0.0528525657715943	0.101274323566838	NA	NA	NA	NA	0.0635296854048244	NA	-0.0151079276095808	NA	0.341655094061293	NA	NA	NA	NA	0.403859945843974	NA	0.279450242278613	NA	p.Tyr29Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.569	-3.435	0.866	8.466	8.466	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.355	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y29E	29	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr29Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.569	-3.062	0.493	10.909	10.909	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29F	29	Y	F	missense	possibly_wt-like	0.881937408977753	0.555958187997685	7	0.21013244354171	0.470085387652605	1.2937894303029	1.26764949949177	1.32541757735509	1.14980240142864	NA	-0.287143202752966	0.777297999487165	0.821888943124232	1.11864864471035	0.856008651089632	0.910230581176625	0.919218720384433	0.857975198507723	NA	0.272870356996096	0.674450694128337	0.730251226723929	0.856008651089632	p.Tyr29Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.569	-3.659	1.09	14.251	14.251	72.46	0.003236709	0	0.092510531	4.071e-06	1	245610	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
Y29G	29	Y	G	missense	wt-like	0.850366528385654	0.0836598435817311	8	0.029578221354824	0.792394279803445	0.908338776967862	0.664865336727019	0.879882680605185	0.89751315834574	0.910263033754665	0.869465749457609	0.876814346363377	0.793623971608505	0.910503950223129	0.714431265476968	0.623440030592725	0.71383463113855	0.734239318017137	0.694894537106445	0.704907552411292	0.723499583710548	0.715027899815386	0.751468382715722	p.Tyr29Gly	0	0	NA	0.584182432102551	-0.58635079245883	0.406084691916559	0.762280172288543	NA	NA	5.03	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.569	-2.995	0.426	17.08	17.08	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.66	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29H	29	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr29His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.569	-2.885	0.316	9.751	9.751	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.66	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Y29I	29	Y	I	missense	possibly_low	0.490620608936198	0.513769880985002	4	0.256884940492501	-0.012864622599819	0.994105840472215	1.10035933200952	0.350120638538569	0.636963446091292	NA	-0.124960980894592	NA	NA	NA	0.538037657744347	0.830637847652487	0.469623245407371	0.606452070081324	NA	0.333451551827744	NA	NA	NA	p.Tyr29Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.569	-4.129	1.56	8.338	NA	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.355	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29K	29	Y	K	missense	possibly_wt-like	0.825138611794961	0.246575522720061	4	0.12328776136003	0.583499039794733	1.06677818379519	0.771707676266259	1.05956006519509	NA	NA	NA	0.502037034427624	NA	0.967249671290868	0.727120958914313	0.674273106965518	0.796662881543357	NA	NA	NA	0.538782081831982	NA	0.779968810863107	p.Tyr29Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.569	-2.805	0.236	12.513	12.513	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.035	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29L	29	Y	L	missense	wt-like	0.980044343317193	0.194218426381956	8	0.0686665831630306	0.845460313376229	1.11462837325816	1.07535487515754	1.11919125936818	1.14195853051589	0.962805487347663	0.596952029627284	0.777561567160891	1.08626773528825	1.08026326207185	0.821446586352963	0.818741314215475	0.82415185849045	0.85412815270433	0.717937111108429	0.603113369509082	0.674580599436679	0.872643897403227	0.836729667243564	p.Tyr29Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.569	-2.992	0.423	27.209	27.209	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.315	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29M	29	Y	M	missense	wt-like	0.975035468158223	0.267354454325583	8	0.0945240738170243	0.78977168780485	1.1602992485116	1.18774844810333	1.16486528920731	1.07893273781616	0.821597038523329	0.682317537037668	1.29665914781712	0.53641621563082	1.03174733113005	0.817789816340156	0.872215537093813	0.845206817572512	0.823216997484145	0.65600992824513	0.635000615700881	0.930429620378649	0.576497501846208	0.812362635196168	p.Tyr29Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.569	-3.952	1.383	3.899	3.899	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29N	29	Y	N	missense	possibly_wt-like	0.741046294915813	0.402716140195934	5	0.180100133022889	0.388056520580077	1.09403606925155	0.920867308533214	0.852084511700761	0.814345179590838	NA	0.0430322691451203	1.07490220560913	NA	NA	0.701020143104534	0.745239757559865	0.701020143104534	0.693449378049389	NA	0.39620338550249	0.821131679750079	NA	NA	p.Tyr29Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.569	-2.987	0.418	11.71	11.71	72.46	0.003236709	0	0.092510531	4.072e-06	1	245582	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.66	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y29P	29	Y	P	missense	low	0.450216303704673	0.25481859557686	8	0.0900919784524149	0.273639270641981	0.626793336767365	0.359086156274228	0.43845186567766	0.779878807744974	0.752064852705206	0.470667661982079	-0.0426503113604244	0.39585211765663	0.448379278957034	0.514854809519672	0.477957476577159	0.510342454542895	0.676545261109838	0.625516480991131	0.55594138115646	0.270320564513446	0.500790607400023	0.519367164496448	p.Tyr29Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.569	-4.275	1.706	1.225	NA	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y29Q	29	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr29Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.569	-3.42	0.851	8.918	8.918	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.315	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29R	29	Y	R	missense	possibly_wt-like	0.841368879373928	0.2195028305478	8	0.0776059699849955	0.689263973218041	0.993473785529816	0.976533480965174	0.953923552847156	0.97413434605262	1.06607978765175	0.615511588168803	0.420480662416747	0.794360475964024	0.929927140925154	0.75459493483638	0.771724415297781	0.747966227166873	0.771818368194993	0.763228214673814	0.610046066688277	0.498585173373685	0.715424576195102	0.761223642505887	p.Tyr29Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.569	-3.045	0.476	15.708	15.708	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.11	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29S	29	Y	S	missense	wt-like	0.861129727846938	0.188823864448001	8	0.0667593175005155	0.730283869913453	0.991975585780422	0.77704015581921	0.93822606958805	1.00431694666999	0.860485745159543	0.478766767346696	0.940793809745477	0.78730960622427	1.10209872222227	0.72617848795265	0.676810175524111	0.740729951566145	0.786621498987448	0.673064630475971	0.558966703380029	0.755033313931386	0.711627024339155	0.84769648467706	p.Tyr29Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.569	-2.857	0.288	8.786	8.786	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y29T	29	Y	T	missense	possibly_low	0.390558613470919	0.471924066158695	4	0.235962033079348	-0.0719184730834507	0.85303570002529	NA	NA	NA	NA	0.064851835217771	0.00333816420083645	0.465970830639031	1.02807362382604	0.471454950871529	NA	NA	NA	NA	0.404353818812891	0.292987028171566	0.538556082930166	0.810517522840866	p.Tyr29Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.569	-1.589	-0.98	10.19	10.19	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-1.97	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y29V	29	Y	V	missense	possibly_wt-like	0.840394644267085	0.419838297921904	7	0.158683961023143	0.529379795737566	1.1514094927966	0.469874138157376	1.15984227675583	1.15384639688927	1.17569530196117	0.222810525697306	0.514217368600985	NA	1.18647650180766	0.81130026741436	0.530667796929002	0.842891293367463	0.85995858603906	0.81130026741436	0.4633573649084	0.544785435900905	NA	0.890075060524899	p.Tyr29Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.569	-3.784	1.215	6.944	NA	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.355	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29W	29	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr29Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.569	-5.469	2.9	0.662	NA	72.46	0.003236709	0	0.092510531	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.355	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y29X	29	Y	X	nonsense	low	0.168891762455647	0.121479851729604	6	0.0495939417944143	0.0716894226872195	0.266094102224075	NA	0.0441618344271147	0.185375568646892	0.374566759261661	0.144843372090894	0.210892764641319	NA	0.0535102756660023	0.390127353018649	NA	0.328581385863729	0.384969683628178	0.459964110308927	0.434233683724505	0.39528502240912	NA	0.321044974837576	p.Tyr29Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.3	103.2	38.1	0.927	91.2	-95.6	-147.6	162.4	15.6862745098039	-3.5	0	1	42.15	0	0	0	0	6	20.3768083334952	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P30A	30	P	A	missense	possibly_low	0.695151471399002	0.299100269002835	8	0.105747914233312	0.487889368061479	0.902413574736525	0.622609246972965	0.715858020698769	0.842309663597435	0.968157441448358	1.15232147458111	0.180311651939598	0.507970830628222	0.571673441325561	0.620778799346652	0.603335575308923	0.63822202338438	0.707164628088346	0.720284218827755	0.810564865503953	0.380212427129134	0.561177005425648	0.581291417981245	p.Pro30Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.935	-2.941	1.006	9.272	9.272	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.36	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
P30C	30	P	C	missense	low	0.529425826796797	0.168101207811759	7	0.0635362844227862	0.404896997616643	0.653954655976951	0.573682460037343	0.591989949883043	0.605809143158331	0.675241222714296	0.608815035361058	NA	0.172124841631952	0.478318134791555	0.581120927383333	0.580057358941708	0.581120927383333	0.591172365495529	0.591825359657535	0.607544650899926	NA	0.38029257472426	0.534403896667111	p.Pro30Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.935	-5.493	3.558	0.737	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30D	30	P	D	missense	possibly_wt-like	0.792721284348991	0.377127220593906	6	0.15396154309485	0.490962204878873	1.09448036381911	NA	0.350064751680064	0.358684014753457	0.913514365639709	1.21093747744629	1.16191370727384	NA	0.76121338930059	0.686403951142337	NA	0.469597482506151	0.469969237764558	0.696320413715606	0.832460159878012	0.864017272635068	NA	0.676487488569069	p.Pro30Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.935	-1.813	-0.122	18.113	18.113	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.045	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P30E	30	P	E	missense	wt-like	0.86635706466546	0.173456736498323	8	0.0613262173102262	0.746159887429339	0.98655424190158	1.03685404627086	0.784917402028191	0.584635882439561	0.757314076764957	1.09969147238986	0.775038142840866	1.00990942498287	0.882496069606513	0.7053691758002	0.800423523874563	0.670057235938312	0.580787887640352	0.627818536292673	0.790905568817771	0.673336872504099	0.831517815980643	0.737401479096301	p.Pro30Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.935	-2.009	0.074	13.416	13.416	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.915	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P30F	30	P	F	missense	low	0.494959260834684	0.0839374787038855	8	0.0296763801936094	0.436794624463692	0.553123897205676	0.594957494477983	0.471518360186644	0.469739310246888	0.645210138637762	0.435289699180684	0.388915895134557	0.469644744666627	0.484398444146329	0.538996274488882	0.590179520766493	0.525585552017017	0.524436580894629	0.578655181451667	0.542726373785987	0.483027761614608	0.540534828751469	0.537457720226296	p.Pro30Phe	0	0	NA	NA	NA	NA	NA	NA	NA	3.476	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.935	-4.733	2.798	1.289	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30G	30	P	G	missense	wt-like	0.814705086018216	0.0882351148277004	8	0.0311958240167203	0.753562394477394	0.875847777559037	0.956811477734673	0.76858996724214	0.671708266807032	0.832779616038352	0.820753873059561	0.908686299630796	0.78086579934258	0.777445388290591	0.685675901222355	0.762341149255836	0.66253056328547	0.623492752954739	0.660914064849005	0.686711823922245	0.73920839905249	0.708156432527629	0.684639978522465	p.Pro30Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.935	-3.121	1.186	14.676	14.676	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P30H	30	P	H	missense	wt-like	1.04170423246769	0.138208472212087	6	0.0564233725082068	0.931116454465313	1.15229201047006	NA	0.94858749665308	1.06762812628112	1.2480918878389	1.14652113987078	NA	0.957193877760244	0.882202866401985	0.805761895810419	NA	0.745506395064876	0.817672622921049	0.843049901729134	0.808398221076785	NA	0.803125570544052	0.737254218356531	p.Pro30His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.935	-3.462	1.527	14.759	14.759	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.865	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P30I	30	P	I	missense	low	0.205142805565585	0.32447275619881	2	0.229436886218468	-0.244545228147625	0.654830839278796	NA	NA	NA	NA	-0.0242940806528822	0.434579691784053	NA	NA	0.438294323480715	NA	NA	NA	NA	0.371054447057325	0.505534199904106	NA	NA	p.Pro30Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.935	-4.36	2.425	4.563	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30K	30	P	K	missense	wt-like	0.911266876724201	0.133197106573175	8	0.0470922886461598	0.818967687028163	1.00356606642024	0.822672958985778	0.916866321505971	0.777987689375438	1.06739969993163	1.14322498459463	0.893891846826998	0.770262569877295	0.897828942695865	0.731400042238848	0.698521191760505	0.730883467175447	0.675617757448933	0.763807064238415	0.807166982395432	0.731916617302248	0.702445603194349	0.745102384813129	p.Pro30Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.935	-3.054	1.119	7.769	7.769	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P30L	30	P	L	missense	low	0.315947695039949	0.162306423944488	8	0.0573839865006429	0.203477148209356	0.428418241870542	0.666899419550234	0.217704487271757	0.351656968827008	0.350983396875322	0.262311649606349	0.333849327044806	0.124687178057394	0.219489133086722	0.452754272229809	0.624407799437426	0.408581628178798	0.466522805786992	0.449621590387565	0.478112528921954	0.455886954072053	0.354742962548951	0.404407533474506	p.Pro30Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.935	-3.486	1.551	7.548	7.548	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.565	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P30M	30	P	M	missense	low	0.43640000657479	0.194519141094988	6	0.079412106814528	0.280755137281867	0.592044875867712	NA	0.176374641272124	0.53566170018292	0.662983386683491	0.502976238447339	NA	0.216602489640292	0.523801583222572	0.557008124813717	NA	0.389529264736048	0.55676837936175	0.586449666774368	0.568009856622805	NA	0.404247942072758	0.557247870265685	p.Pro30Met	0	0	NA	NA	NA	NA	NA	NA	NA	3.585	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.935	-5.124	3.189	1.002	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30N	30	P	N	missense	possibly_wt-like	0.854718752611466	0.222261074327889	6	0.0907377036310224	0.676876121454793	1.03256138376814	0.635973988015699	0.858825751601278	0.537339639099115	NA	1.03587901486444	1.07506399112419	0.985230130964081	NA	0.735598471652587	0.609694205277695	0.704127741246578	0.557591328634845	NA	0.767069202058597	0.821211419412086	0.818225711280979	NA	p.Pro30Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.935	-2.866	0.931	16.111	16.111	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.665	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P30P	30	P	P	synonymous	wt-like	0.944152537304663	0.256176066446737	8	0.0905719168810915	0.766634842206968	1.12167023240236	0.732512943210137	1.11654107057788	1.14149879852205	1.04745261467194	0.419701557300517	1.12475014299942	1.09536719303319	0.875395978122157	0.788994702657416	0.655625173314446	0.822930166059633	0.853902676015938	0.755059239255199	0.536903613131429	0.845700366741763	0.877544805223518	0.733835471944006	p.Pro30=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P30Q	30	P	Q	missense	possibly_wt-like	0.811433910465838	0.188322116438728	7	0.0711790694957462	0.671925497801102	0.950942323130574	1.00046469997009	1.05300215997193	0.65640349490593	0.668803505057116	0.886785122924794	0.554064608830326	NA	0.860513781600674	0.711376993551973	0.783110327368007	0.793639797602132	0.615986489890371	0.589002088657126	0.711376993551973	0.56442505238116	NA	0.72636091765771	p.Pro30Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.935	-3.387	1.452	5.255	5.255	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.105	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P30R	30	P	R	missense	possibly_low	0.515693369851473	0.281636146003098	8	0.0995734143330177	0.320533063941074	0.710853675761872	0.349215592905917	0.72500806359142	0.677955237476846	0.775036176352494	0.524268456635519	0.0995522740698046	0.159190817504431	0.81532034027535	0.601259950325961	0.473261294298601	0.642440039166705	0.626556595101883	0.635590590380204	0.57596330555004	0.340408335317053	0.373326394785721	0.703662599564476	p.Pro30Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.935	-3.095	1.16	13.488	13.488	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.32	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P30S	30	P	S	missense	possibly_low	0.51579984390907	0.291001300174747	8	0.102884496343833	0.314149936507615	0.717449751310525	0.4743422386144	0.479031783055235	0.425356995360801	0.0311791640838514	1.06423152562825	0.662350697554627	0.603444951672431	0.386461395302967	0.530921363861102	0.53279361421036	0.529049113511845	0.502669165274629	0.309370951212484	0.777659937336898	0.6177963082185	0.612598736211866	0.48826902773977	p.Pro30Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.935	-2.657	0.722	8.895	8.895	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.44	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P30T	30	P	T	missense	possibly_wt-like	0.715153964266847	0.100127458231334	7	0.0378446219841597	0.640979868169361	0.789328060364333	NA	0.736673752339622	0.752750957634445	0.872150293455193	0.572453754757513	0.758909597555156	0.609207123138447	0.703932270987553	0.64781772535123	NA	0.64781772535123	0.66324034022528	0.678180136108507	0.593962337133777	0.66538755300361	0.615702203692151	0.647718158195528	p.Pro30Thr	1	0	NA	NA	NA	NA	NA	NA	NA	2.652	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.935	-3.087	1.152	9.031	9.031	21.84	0.003887518	0	0.111111727	0	NA	NA	not specified	Uncertain significance(Last reviewed: Nov 20, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.36	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
P30V	30	P	V	missense	low	0.306205999218019	0.106484292474725	8	0.0376478826493648	0.232417505131074	0.379994493304965	0.439281764092557	0.297720763417943	0.378288260243501	0.442970870950075	0.153516773819059	0.20589481432711	0.242757201213808	0.289217545680101	0.44244813902919	0.516112663692792	0.445467784843551	0.479584188237366	0.489962838914746	0.437473527364124	0.392821669193352	0.41833469691915	0.439428493214828	p.Pro30Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.935	-3.512	1.577	7.482	7.482	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30W	30	P	W	missense	low	0.482717434755324	0.253628639803169	7	0.0958626151832517	0.294830161532328	0.67060470797832	0.329106642629972	0.584026828523751	0.538525562494742	0.615018320393607	0.119944946199389	0.891264759320819	NA	0.301134983724986	0.558172967684371	0.463693927938392	0.57745006245252	0.558172967684371	0.565414513028865	0.424933179805821	0.730621797616255	NA	0.44541400331688	p.Pro30Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-0.187	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.935	-5.868	3.933	0.241	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P30X	30	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro30Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P30Y	30	P	Y	missense	possibly_low	0.545779530579021	0.358613215476726	8	0.126788918243353	0.297277817183256	0.794281243974786	0.81784042615286	0.809440205897223	0.75429405370872	0.802385987441836	-0.112245806680625	0.498251869132363	0.107867099866236	0.688402409113557	0.643751603714756	0.696221986111985	0.681361835813962	0.663997155494528	0.647584892185143	0.338201150381446	0.536916477230875	0.34568377956733	0.639918315244369	p.Pro30Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	106.7	37.6	0.867	128.7	33.8	-53.7	-34.8	68.1818181818182	0	0	0	46.53	0	0	0	0	5	22.801064401909	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.935	-4.667	2.732	2.419	NA	21.84	0.003887518	0	0.111111727	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31A	31	N	A	missense	low	0.312024050030419	0.163745088820392	7	0.0618898262038484	0.190722219661433	0.433325880399405	NA	0.443565707023426	0.465715695160928	0.50018506419749	0.107475617032853	0.148650740342713	0.186994276434415	0.331581250021109	0.460705581405966	NA	0.512699849339599	0.522463188968233	0.51505421154229	0.420275413677068	0.364607628463047	0.388301154064849	0.460705581405966	p.Asn31Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.715	-3.495	1.78	7.889	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N31C	31	N	C	missense	possibly_low	0.621920700514229	0.529248132303609	6	0.216064645244141	0.19844177750329	1.04539962352517	NA	0.178786934137912	0.432064736530277	0.63028534729635	1.65945922740996	0.471589676295274	0.359338281415604	NA	0.514867201987152	NA	0.390641291149351	0.505958993447903	0.572109891206705	1	0.5237754105264	0.481124496451605	NA	p.Asn31Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.715	-3.921	2.206	14.511	14.511	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31D	31	N	D	missense	low	0.262646186425402	0.364056621925053	4	0.182028310962527	-0.0941227472278073	0.619415120078612	NA	NA	NA	NA	-0.264714795811324	0.304770657908682	0.505688431732992	0.50484045187126	0.494639775540205	NA	NA	NA	NA	0.281248215402066	0.441554872193791	0.559947720460742	0.547724678886619	p.Asn31Asp	1	0	NA	NA	NA	NA	NA	NA	NA	3.648	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.715	-3.253	1.538	15.751	15.751	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N31E	31	N	E	missense	low	0.525054315666559	0.153665796520968	7	0.0580802118015906	0.411219192320983	0.638889439012135	NA	0.651991667189077	0.387477478743289	0.617687299374989	0.653676365061462	0.567570748360396	0.244104814701834	0.552871836234866	0.571081859702638	NA	0.608780709258975	0.484091063077519	0.566584997874598	0.624302054540383	0.571081859702638	0.419060512639968	0.571848348356609	p.Asn31Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.715	-3.582	1.867	3.727	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N31F	31	N	F	missense	low	0.326835413795987	0.167625220110662	8	0.0592644649190684	0.210679196991576	0.442991630600399	0.0991404745142568	0.354732806410249	0.458318908735994	0.523580827264644	0.0917872359310433	0.376296364663851	0.235538086625878	0.475288606221983	0.474278658430324	0.354281425016819	0.471749377175464	0.518835416852759	0.525314459493094	0.414415209881415	0.476807939685183	0.414446529499588	0.532882321829521	p.Asn31Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.715	-4.625	2.91	1.506	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31G	31	N	G	missense	low	0.588536315738235	0.168984354651257	8	0.0597449915441682	0.471438284055016	0.705634347421455	0.606914645674431	0.613850890784674	0.748676635207496	0.777643146691451	0.220834380644773	0.579286809236207	0.548238802052848	0.612845215614002	0.593533452883604	0.595868452538217	0.591198453228991	0.661242078758637	0.636733881240233	0.462619199978414	0.57685638614251	0.582865068779962	0.601969861619442	p.Asn31Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.715	-3.591	1.876	4.838	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N31H	31	N	H	missense	possibly_low	0.69428868495458	0.272939641176191	3	0.157581775305593	0.385434080735734	1.00314328917343	NA	NA	0.55580317362334	1.00870968208726	NA	NA	NA	0.518353199153137	0.566646814605655	NA	NA	0.566646814605655	0.738068466459327	NA	NA	NA	0.554511429953209	p.Asn31His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.715	-3.043	1.328	9.927	9.927	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.49	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N31I	31	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn31Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.715	-4.355	2.64	2.326	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N31K	31	N	K	missense	possibly_wt-like	0.724761785841912	0.0953960285642473	4	0.0476980142821236	0.631275395714873	0.818248175968952	0.784882576240955	0.770923332539203	NA	NA	0.760805373212206	NA	NA	0.582435861375285	0.663962498469031	0.680541415011802	0.663606205417907	NA	NA	0.664318791520154	NA	NA	0.586696822539467	p.Asn31Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.715	-2.228	0.513	11.482	11.482	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	1.975	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N31L	31	N	L	missense	low	0.312116313567024	0.255737187863548	8	0.0904167498699463	0.134902740222763	0.489329886911285	0.308598753426425	0.0996023810993616	0.352182222855942	0.456068525749092	0.826004598477931	-0.0140041507950531	0.296460679538668	0.172017498183825	0.450597895662002	0.45393675580397	0.354138544839685	0.466780417918834	0.495706835613047	0.688673168488455	0.284439474729	0.447259035520033	0.380564997083545	p.Asn31Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.715	-3.817	2.102	3.063	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31M	31	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn31Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.715	-4.952	3.237	1.08	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31P	31	N	P	missense	low	0.250658190873891	0.184087912503062	6	0.0751535755744363	0.103359889438586	0.397956492309195	NA	0.203572154720849	0.404195059398636	0.507967586487088	-0.0196604278359142	NA	0.202327263924344	0.205547508548342	0.399736120176457	NA	0.402066860713753	0.492290241674215	0.518467248686868	0.372785291664523	NA	0.396559399820161	0.397405379639161	p.Asn31Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.715	-4.216	2.501	2.102	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31Q	31	N	Q	missense	possibly_wt-like	0.831986849424687	0.248731348825034	8	0.087939811723929	0.659627985638553	1.00434571321082	1.00681166386437	0.802330938020611	0.954819304821625	0.934522811227211	0.653755582203408	1.1069172181637	0.315951983891459	0.880785293205112	0.721037972439577	0.786130063754952	0.678084582968687	0.762345258663153	0.705533699906359	0.624331645139496	0.836911005107706	0.457756923263219	0.736542244972795	p.Asn31Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.715	-3.395	1.68	7.166	7.166	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.94	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N31R	31	N	R	missense	wt-like	0.914867640988046	0.152750680305743	7	0.057734330383561	0.80171043276473	1.02802484921136	0.905409958414512	0.827646268245012	0.954377464773581	1.14077372143254	0.642270989035087	0.965644497985958	NA	0.967950587029629	0.762128557123632	0.737885513329596	0.689754524156293	0.762128557123632	0.795985354452163	0.620041715156296	0.767281539492413	NA	0.780320844430996	p.Asn31Arg	0	0	NA	NA	NA	NA	NA	NA	NA	-0.534	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.715	-1.448	-0.267	14.257	14.257	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.595	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N31S	31	N	S	missense	possibly_low	0.68472207654788	0.118294362940769	8	0.0418233731057802	0.60274977154857	0.76669438154719	0.691838969897777	0.516878049013985	0.68118910161757	0.935568391485941	0.71018813254288	0.612529681161264	0.673206544966181	0.656377741697445	0.63220805180813	0.636273451883703	0.546495605182863	0.628142651732557	0.70599224074028	0.645411337400389	0.59324088985099	0.650171869437232	0.623833988259656	p.Asn31Ser	1	0	NA	NA	NA	NA	NA	NA	NA	1.185	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.715	-2.725	1.01	15.88	15.88	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.255	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N31T	31	N	T	missense	possibly_low	0.638599460501703	0.311057879514447	5	0.139109312706249	0.365950217683336	0.91124870332007	1.06444101832123	0.419297257784672	0.830585727950539	NA	0.583078546989862	NA	NA	0.29559475146221	0.597931098943169	0.813548757402565	0.501512502667831	0.701414594982071	NA	0.597931098943169	NA	NA	0.442631432427762	p.Asn31Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.715	-2.903	1.188	10.801	10.801	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.145	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N31V	31	N	V	missense	low	0.200728100127828	0.189390354981317	8	0.0669596021493083	0.0694896914960532	0.331966508759603	0.129935814435091	0.0755892071767946	0.440013943934663	0.535525422635389	0.00180320545252519	0.208358936842332	0.0627154659859079	0.151882804559923	0.375627578474636	0.368933124641451	0.343068875792508	0.509857701792994	0.530552780202023	0.38080277061593	0.394036167885878	0.321365407881279	0.370452386333342	p.Asn31Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.715	-4.045	2.33	3.142	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31W	31	N	W	missense	low	0.281181174778993	0.181496106023451	7	0.0685990800663804	0.146729448476308	0.415632901081678	0.27206854661962	0.23307076420865	0.352265780575961	0.398116781132978	0.0777215667985865	NA	0.0601365157409071	0.574888268376249	0.436556541176208	0.436556541176208	0.415665223239042	0.466821399008364	0.470292008696041	0.409161150389648	NA	0.319976402318735	0.582906058620934	p.Asn31Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.715	-5.74	4.025	0.363	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N31X	31	N	X	nonsense	low	0.0236428744426264	0.0273981263465173	2	0.0193734009314282	-0.0143282936410276	0.0616140425262803	0.0430162753740545	NA	NA	NA	NA	NA	NA	0.00426947351119819	0.311946363279004	0.327578848926111	NA	NA	NA	NA	NA	NA	0.296313877631897	p.Asn31Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N31Y	31	N	Y	missense	low	0.438913940550935	0.140814293103072	7	0.0532228000848696	0.334599169228215	0.543228711873654	NA	0.446999786262435	0.28923699989792	0.416848370629274	0.705874447997328	0.286381573905303	0.451892593199969	0.475163811964313	0.514282902074743	NA	0.514282902074743	0.43590877832686	0.47850677613889	0.643800013046203	0.432491394894712	0.530973637261977	0.532819644156086	p.Asn31Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.2	105.2	37.6	0.448	111.5	69.1	-100.9	0.6	28.3422459893048	-3.4	0	0	39.87	0	0	0	0	5	21.7851265284368	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.715	-4.475	2.76	1.627	NA	72.21	0.003671423	0	0.104935386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I32A	32	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.309	-3.369	2.06	3.891	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32C	32	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.309	-3.734	2.425	12.352	12.352	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.33	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I32D	32	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.309	-4.301	2.992	1.339	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32E	32	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.309	-4.142	2.833	1.975	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32F	32	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.309	-3.371	2.062	27.929	27.929	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I32G	32	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.309	-4.066	2.757	1.837	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32H	32	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.309	-5.226	3.917	1.238	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32K	32	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.309	-3.395	2.086	7.7	7.7	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.33	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32L	32	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.309	-1.833	0.524	32.706	32.706	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.15	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I32M	32	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.309	-3.549	2.24	4.341	3.336	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.33	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I32N	32	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.309	-4.449	3.14	1.206	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I32P	32	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.309	-4.381	3.072	1.246	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32Q	32	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.309	-4.537	3.228	1.48	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32R	32	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.309	-4.401	3.092	2.979	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32S	32	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.309	-3.941	2.632	2.138	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I32T	32	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.309	-3.72	2.411	2.927	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	not specified	Uncertain significance(Last reviewed: Nov 9, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I32V	32	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.309	-1.575	0.266	11.223	11.223	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.495	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I32W	32	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.309	-5.575	4.266	1.298	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I32X	32	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I32Y	32	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile32Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	101.9	36	0.954	60.2	-175.8	-125.8	114.2	2.61780104712042	-6	0	1	35.4	0	0	0	0	9	18.1221449574823	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.309	-4.268	2.959	6.478	NA	87.1	0.003287146	0	0.093952109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33A	33	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.108	-3.317	2.209	5.294	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33C	33	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.108	-3.036	1.928	13.192	13.192	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33D	33	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.108	-4.232	3.124	2.7	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33E	33	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.108	-4.14	3.032	2.918	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33F	33	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.108	-3.992	2.884	2.731	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I33G	33	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.108	-4.028	2.92	3.112	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33H	33	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.108	-5.19	4.082	1.059	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33K	33	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.108	-4.098	2.99	3.341	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33L	33	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.108	-1.966	0.858	18.729	18.729	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.085	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
I33M	33	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.108	-3.441	2.333	3.095	3.095	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.265	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I33N	33	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.108	-4.382	3.274	3.184	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I33P	33	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.108	-4.341	3.233	1.924	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33Q	33	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.108	-4.528	3.42	1.964	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33R	33	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.108	-4.384	3.276	2.535	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33S	33	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.108	-3.853	2.745	6.692	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	1	0	0	1	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I33T	33	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.108	-3.084	1.976	17.818	17.818	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I33V	33	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.108	-1.986	0.878	19.441	19.441	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
I33W	33	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.108	-5.542	4.434	0.407	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I33X	33	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I33Y	33	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile33Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.7	32.3	0.91	11.8	-157.8	-111.6	134.1	0	-7.6	0	1	29.86	0	0	0	0	8	15.8467857264494	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.108	-4.262	3.154	1.534	NA	72.21	0.00223658	0	0.063925171	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34C	34	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-0.972	-3.246	2.274	35.018	35.018	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34D	34	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-0.972	-3.929	2.957	1.945	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34E	34	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-0.972	-3.742	2.77	2.871	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34F	34	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-0.972	-4.357	3.385	1.508	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34G	34	A	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-0.972	-2.664	1.692	14.043	14.043	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34H	34	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-0.972	-4.97	3.998	0.851	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34I	34	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-0.972	-3.758	2.786	4.522	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34K	34	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-0.972	-3.767	2.795	2.512	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34L	34	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-0.972	-3.421	2.449	4.603	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34M	34	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-0.972	-4.727	3.755	1.107	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34N	34	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-0.972	-4.069	3.097	2.183	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34P	34	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-0.972	-4.01	3.038	1.156	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34Q	34	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-0.972	-3.367	2.395	5.945	5.945	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34R	34	A	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-0.972	-4.06	3.088	2.017	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34S	34	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-0.972	-2.464	1.492	8.731	8.731	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34T	34	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-0.972	-2.799	1.827	7.506	7.506	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34V	34	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-0.972	-2.366	1.394	7.415	7.415	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A34W	34	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-0.972	-5.572	4.6	0.425	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A34X	34	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A34Y	34	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala34Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	98.5	30.4	0.941	29.1	163.4	-109.4	125.5	0	-7.2	0	1	39.49	0	0	0	0	8	12.0771957779942	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-0.972	-4.436	3.464	1.016	NA	72.46	0.001211494	0	0.034626524	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35A	35	M	A	missense	low	0.522027197740106	0.187285887628181	6	0.076459143452212	0.372170030284989	0.671884365195223	NA	0.664152094369266	0.674649993196121	0.296157606065857	0.702439922635902	NA	0.3045162019834	0.490247368190091	0.577390896248515	NA	0.614386461534416	0.624935529905783	0.425577655330205	0.642517087903788	NA	0.451597686685029	0.540395330962615	p.Met35Ala	0	0	NA	NA	NA	NA	NA	NA	NA	3.428	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-1.145	-3.364	2.219	3.237	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M35C	35	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met35Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-1.145	-4.979	3.834	1.149	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35D	35	M	D	missense	low	0.421976036949061	0.107170095381575	7	0.0405064886232454	0.342584778107319	0.501367295790804	NA	0.455793127876989	0.458680163414857	0.535888440185812	0.481355172325861	0.211360591705303	0.45542722522675	0.355327537907857	0.519012595099537	NA	0.518336484570991	0.519012595099537	0.530711982108246	0.559933570552948	0.395515601592593	0.532877366717892	0.472632108357231	p.Met35Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-1.145	-4.136	2.991	2.316	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35E	35	M	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met35Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-1.145	-3.951	2.806	1.467	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35F	35	M	F	missense	wt-like	1.10980210855726	0.19455680618569	4	0.097278403092845	0.919139942021714	1.30046427509281	NA	1.03012051031482	1.18465525162469	1.33759739722166	NA	NA	NA	0.886835275067865	0.82908030345202	NA	0.783091742198276	0.875068864705765	0.882302680815421	NA	NA	NA	0.73958083660804	p.Met35Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-1.145	-3.015	1.87	9.852	9.852	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35G	35	M	G	missense	low	0.375145595583502	0.128576785816192	8	0.0454587585768998	0.286048065990877	0.464243125176127	0.442203539721982	0.307861974665324	0.457096639287071	0.488743450003184	0.186752706684452	0.525995957001894	0.205744079337868	0.386766417966244	0.499229349391609	0.517502775930649	0.450142712556481	0.518235951791898	0.510036474003486	0.449888405525604	0.55059078045027	0.398399674026604	0.488422224779731	p.Met35Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-1.145	-3.842	2.697	1.78	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35H	35	M	H	missense	low	0.533922595389126	0.133070025326738	6	0.0543256103516237	0.427446355661787	0.640398835116465	NA	0.58001570984573	0.43265171372329	0.405031713733174	0.539711384234655	NA	0.770743884808236	0.475381165989672	0.554264907020154	NA	0.575601004247311	0.506246877857551	0.473324563045196	0.581731823177522	NA	0.702704836236053	0.532928809792996	p.Met35His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-1.145	-3.605	2.46	7.028	7.028	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.275	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35I	35	M	I	missense	wt-like	0.994501105988001	0.142993716908051	7	0.0540465448547823	0.8885718245838	1.1004303873922	1.18892160667937	1.10769187898134	1.02310032761644	0.732509223010538	0.992220073700246	NA	0.961800589779684	0.955264042148402	0.795833854423606	0.872773698397191	0.818850837661617	0.795833854423606	0.61694032944927	0.750760936019913	NA	0.805606715200662	0.773949051914793	p.Met35Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-1.145	-2.636	1.491	8.338	7.344	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	1	0	0	0	1	1	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M35K	35	M	K	missense	low	0.356400875207199	0.33799874289235	7	0.127751516735088	0.106012503436061	0.606789246978338	NA	0.333549780199162	0.378383081899908	0.68083219406294	-0.1358773620212	0.0823153714453541	0.86389644832048	0.291706612543751	0.461984358593142	NA	0.461984358593142	0.479630693752234	0.594277288759325	0.329373870536233	0.331912736753557	0.752876191474344	0.440678622210754	p.Met35Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-1.145	-3.827	2.682	1.805	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M35L	35	M	L	missense	wt-like	0.884312033427592	0.227244499335383	8	0.0803430632336956	0.726842523081924	1.04178154377326	0.798875689728532	1.15536717987379	0.916658389234699	1.12476007375672	0.733767853950007	0.505820870533262	1.08307917776697	0.75616703257676	0.715414076741762	0.687199009834929	0.840828349018749	0.743629143648595	0.788962544583592	0.654219255310705	0.540647031311825	0.87092656138942	0.67395296570977	p.Met35Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-1.145	-2.253	1.108	27.209	27.209	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	1	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.02	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
M35N	35	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met35Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-1.145	-3.324	2.179	8.802	8.802	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35P	35	M	P	missense	low	0.372339117150519	0.167365203141658	7	0.0632581008055191	0.248355517841298	0.496322716459741	0.471152036926051	0.373941738299528	0.444795777542576	0.574037787689128	0.326015269426413	0.0403632425738349	NA	0.376067967596107	0.501908240681105	0.531275791156617	0.480604371498569	0.512202963860471	0.54744243725185	0.501908240681105	0.311235678146116	NA	0.483048948868787	p.Met35Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-1.145	-4.227	3.082	1.036	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35Q	35	M	Q	missense	low	0.376256704900798	0.175104696198476	2	0.123817718099553	0.133578436777741	0.618934973023854	0.50007442300035	NA	NA	NA	NA	NA	NA	0.252438986801245	0.482996458400044	0.54503638332016	NA	NA	NA	NA	NA	NA	0.420956533479927	p.Met35Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-1.145	-4.114	2.969	1.185	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35R	35	M	R	missense	low	0.343871147334104	0.186191150053552	8	0.0658285123998942	0.214849633874463	0.472892660793745	0.711853512014215	0.231220696878798	0.37290710949859	0.445601907738518	0.0744196489836614	0.335552858776979	0.240534792661886	0.338878652120187	0.460548632885243	0.645795901058431	0.414812373335797	0.47694498960433	0.491116684153289	0.407927759182079	0.456726578339361	0.417137722356787	0.464370687431125	p.Met35Arg	1	0	NA	NA	NA	NA	NA	NA	NA	4.368	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-1.145	-4.093	2.948	1.772	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	Cowden syndrome 1	Pathogenic(Last reviewed: Sep 1, 2003)	no assertion criteria provided	1	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
M35S	35	M	S	missense	low	0.610035334197037	0.126335063108277	8	0.0446661899127465	0.522491210641428	0.697579457752647	0.513257708077884	0.749660613656285	0.556161071635532	0.752221002366248	0.605786632962585	0.443757759781317	0.504614312093946	0.754823573002502	0.586617887306919	0.551308680801483	0.653804449855063	0.566822346566999	0.62558496066564	0.60641342804684	0.510057818966769	0.559369206719981	0.673278215748987	p.Met35Ser	0	0	NA	NA	NA	NA	NA	NA	NA	4.52	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-1.145	-3.123	1.978	4.857	4.857	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35T	35	M	T	missense	possibly_low	0.601580782987179	0.118147420771233	4	0.0590737103856165	0.485798438198221	0.717363127776137	NA	0.446714906078174	NA	NA	0.700121698431847	0.572313146989376	NA	0.68717338044932	0.606360148228839	NA	0.514151577104206	NA	NA	0.641651143470668	0.573419258471877	NA	0.639301037985801	p.Met35Thr	1	0	NA	NA	NA	NA	NA	NA	NA	3.824	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-1.145	-3.691	2.546	2.435	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Dec 12, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M35V	35	M	V	missense	wt-like	1.06120850439345	0.082293533599916	5	0.036802787047615	0.989076367249431	1.13334064153748	NA	1.07636902747906	0.929226678713643	1.05118457260673	NA	1.15007245575093	NA	1.09918978741691	0.804411530268844	NA	0.804411530268844	0.74979329217088	0.756695895159217	NA	0.858181043144202	NA	0.846235477823229	p.Met35Val	1	0	NA	NA	NA	NA	NA	NA	NA	11.388	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-1.145	-2.408	1.263	7.081	7.081	72.46	0.001462421	0	0.041798437	0	NA	NA	not provided|Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Mar 7, 2017)	criteria provided, multiple submitters, no conflicts	0	1	0	0	0	6	2	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.26	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
M35W	35	M	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met35Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-1.145	-5.264	4.119	0.536	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M35X	35	M	X	nonsense	low	0.180567849008464	0.179175839597811	3	0.103447219224073	-0.0221849749715385	0.383320672988467	0.0327270745293287	NA	NA	NA	0.379833002978189	NA	NA	0.129143469517876	0.359031599491783	0.32268348876636	NA	NA	NA	0.522011199959495	NA	NA	0.359031599491783	p.Met35Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M35Y	35	M	Y	missense	possibly_wt-like	0.72093274906027	0.0819878845455813	7	0.030988507575412	0.660196390277816	0.781669107842724	0.811912205651041	0.696234216283129	0.572765803873403	0.677163805991621	0.751618259079911	0.801009170347587	0.735825782195198	NA	0.660887056865075	0.693401477998598	0.629175779808744	0.574966178379473	0.592668511516904	0.660887056865075	0.686137282692972	0.683898176876479	NA	p.Met35Tyr	0	0	NA	0.54242147923154	-0.621802606706544	0.453433163796273	0.631409794666806	NA	NA	-0.058	36	98.8	26.6	0.802	34.8	-106.7	-137.1	178	0	-4.3	0	1	43.82	0	0	0	0	6	11.238292479732	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-1.145	-4.146	3.001	2.285	NA	72.46	0.001462421	0	0.041798437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36A	36	G	A	missense	possibly_wt-like	0.744990796024824	0.303634247232533	8	0.107350917609298	0.534586863803273	0.955394728246376	0.821646378782719	0.850203218359201	0.830311026773062	0.705043067631836	1.01103606620508	0.0249453231718783	0.810518531685364	0.906222755589458	0.700716382824291	0.698032769005164	0.700152898535412	0.701279867113171	0.604895004676921	0.757789420984691	0.303636606736524	0.724127198248534	0.749318161029469	p.Gly36Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.204	-2.467	1.263	7.26	7.26	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.49	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G36C	36	G	C	missense	possibly_wt-like	0.815074953617252	0.156908909793566	2	0.110951354143618	0.597614295459811	1.03253561177469	NA	0.92602630776087	0.704123599473633	NA	NA	NA	NA	NA	0.687248499679451	NA	0.735106066680426	0.639390932678475	NA	NA	NA	NA	NA	p.Gly36Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.204	-5.204	4	1.199	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36D	36	G	D	missense	wt-like	0.966427058291766	0.302224085583573	7	0.114229967238291	0.742540436549526	1.19031368003401	NA	1.01176685059911	1.13305989259776	1.19104845217104	0.862982383012599	1.23972730226646	0.9782221379151	0.34818238948029	0.814451252527392	NA	0.774631013953335	0.849763793825958	0.818033415101277	0.702485769793755	0.902369468516369	0.814451252527392	0.469043471442754	p.Gly36Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.204	-3.765	2.561	6.038	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36E	36	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.204	-3.764	2.56	3.586	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	4	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G36F	36	G	F	missense	possibly_wt-like	0.860959968424406	0.191310756885556	4	0.0956553784427782	0.673478871749012	1.0484410650998	NA	0.628590574448314	0.893844038896663	1.09265967357685	NA	NA	NA	0.828745586775796	0.721422596441174	NA	0.597993199335554	0.732439789348737	0.774884864611364	NA	NA	NA	0.71040540353361	p.Gly36Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.204	-4.528	3.324	2.271	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36G	36	G	G	synonymous	wt-like	1.03494462064349	0.250374478627172	8	0.0885207458366599	0.861447146919015	1.20844209436797	0.550549684255939	0.814406476763797	1.02268032404225	1.18181608966903	1.35938641644854	1.17067583738626	1.13508888336747	1.04495325321464	0.816489916100316	0.569051327408872	0.683651203103305	0.795627862636459	0.813984548297042	0.887911454065487	0.868335887273564	0.898938645191911	0.818995283903591	p.Gly36=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G36H	36	G	H	missense	possibly_wt-like	0.800363746547132	0.318728035480643	7	0.120467873963707	0.564251052284156	1.03647644081011	0.1693830277116	0.737705754832276	0.828416582464626	0.959479021567118	1.2185261968927	0.808468963362997	NA	0.880566678998615	0.700350732237343	0.38770118245286	0.648293461132197	0.700350732237343	0.7164782844136	0.835294833654444	0.689814010943197	NA	0.736432446412357	p.Gly36His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.204	-3.714	2.51	13.353	13.353	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36I	36	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.204	-4.221	3.017	10.552	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36K	36	G	K	missense	possibly_low	0.67815451122501	0.37383250283673	5	0.167182977708362	0.350481896088457	1.00582712636156	NA	0.917487729344573	0.738405198042307	1.13658652364401	0.281279674555767	NA	0.317013430538391	NA	0.656204427109253	NA	0.731169925731022	0.656204427109253	0.794149052408666	0.485197803755811	NA	0.45832861141416	NA	p.Gly36Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.204	-3.779	2.575	7.073	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36L	36	G	L	missense	low	0.525434068352019	0.173728952622877	4	0.0868644763114385	0.355182823245667	0.695685313458371	NA	0.701275005406299	0.564674200785536	0.285690109721311	NA	0.550096957494928	NA	NA	0.566733568557679	NA	0.631499498760267	0.570997631720792	0.420987118675731	NA	0.562469505394566	NA	NA	p.Gly36Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.204	-3.835	2.631	8.354	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36M	36	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.204	-4.988	3.784	2.038	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36N	36	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.204	-3.216	2.012	22.949	22.949	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36P	36	G	P	missense	possibly_low	0.675281332440002	0.112438499127924	7	0.0424977580688341	0.591987257201391	0.758575407678613	0.675456557599942	0.590355675639164	0.754641952444472	0.819218525427006	0.477006698911294	0.688872704995222	NA	0.721417212062913	0.630868281369509	0.628479084790117	0.58036755446102	0.66416778328612	0.654966827660957	0.558309251240205	0.630868281369509	NA	0.656499935876786	p.Gly36Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.204	-3.377	2.173	11.049	11.049	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36Q	36	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.204	-3.473	2.269	5.945	5.945	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36R	36	G	R	missense	possibly_low	0.670366063895785	0.145831427472897	5	0.0652177970170454	0.542541530591332	0.798190597200238	NA	0.883636177617122	0.58515240357175	0.493921031916867	NA	0.691549118889607	NA	0.697571587483579	0.632187412685143	NA	0.715564930091354	0.581041216701482	0.512307110531455	NA	0.632187412685143	NA	0.644523517264684	p.Gly36Arg	1	0	NA	NA	NA	NA	NA	NA	NA	5.034	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.204	-3.421	2.217	20.147	20.147	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	9	3	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G36S	36	G	S	missense	wt-like	0.871828665562185	0.219783764249004	8	0.0777052950475881	0.719529085860854	1.02412824526352	0.513931713649691	0.926588375456574	0.909866640356802	0.899175352543338	0.929704955978491	1.15241414295927	0.57888213764464	1.06406600590867	0.731387172590741	0.551629356826129	0.735365170428794	0.740298113687871	0.690032017422811	0.727409174752687	0.859335196817677	0.599369366865757	0.828594626807432	p.Gly36Ser	0	0	NA	NA	NA	NA	NA	NA	NA	1.046	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.204	-1.53	0.326	6.712	6.712	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.36	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G36T	36	G	T	missense	wt-like	0.974569465521589	0.0827058773897991	6	0.0337645330556993	0.908392196777606	1.04074673426557	NA	1.01639819151589	0.809354657510732	1.01309356055946	0.974179654885532	1.02152799174313	1.01286273691478	NA	0.760394070669522	NA	0.776765984172545	0.691001764206864	0.739991023119772	0.7440221571665	0.79482498738619	0.833108450274309	NA	p.Gly36Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.204	-3.66	2.456	3.629	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36V	36	G	V	missense	low	0.560917990472215	0.167060193006474	7	0.0631428178105116	0.437160341681238	0.684675639263192	NA	0.551109302922425	0.699382484705655	0.845496979616528	0.353776681757372	0.548891958271931	0.515447744241551	0.412320781790043	0.562275637137748	NA	0.562275637137748	0.637065641266308	0.666491284246298	0.512278178334889	0.561875594186099	0.565204021696983	0.501256854357227	p.Gly36Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.204	-3.102	1.898	17.303	17.303	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G36W	36	G	W	missense	possibly_wt-like	0.756337236948117	0.186674411207802	3	0.107776521561639	0.545099136308299	0.967575337587935	NA	0.60288943906256	0.70195939756209	0.964162874219701	NA	NA	NA	NA	0.638329494521969	NA	0.586145408461495	0.638329494521969	0.718532395213175	NA	NA	NA	NA	p.Gly36Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.204	-5.584	4.38	0.314	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G36X	36	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	2	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G36Y	36	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly36Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	97	23.3	0.352	61.2	-60.3	-95.2	-178.7	1.03092783505155	-2.2	0	0	43.61	0	0	0	0	9	9.5104194365969	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.204	-4.555	3.351	2.189	NA	64.27	0.002773223	0	0.079263329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.295	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37A	37	F	A	missense	wt-like	0.999407466033995	0.248125055733132	8	0.0877254547455939	0.827468734205232	1.17134619786276	0.649422275389331	0.695016019402586	1.06519539534069	0.926862607096149	1.36778437469411	1.23726693967026	1.10572995089163	0.947982165787217	0.793385613851219	0.616092584628945	0.628614211548529	0.816479484041114	0.702174305578725	0.891048409144982	0.901156822985245	0.883126118138171	0.770291743661324	p.Phe37Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.267	-3.106	1.839	6.972	6.972	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.54	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F37C	37	F	C	missense	wt-like	1.08066497885685	0.14403453770728	2	0.101847798337887	0.881046962209889	1.2802829955038	1.18251277719473	NA	NA	NA	NA	NA	NA	0.978817180518959	0.827751548855937	0.869724527815027	NA	NA	NA	NA	NA	NA	0.785778569896848	p.Phe37Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.267	-3.782	2.515	14.391	14.391	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.145	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F37D	37	F	D	missense	wt-like	0.914538216840659	0.0974303019978385	4	0.0487151509989193	0.819058275381347	1.01001815829997	0.812709893393651	0.869917786723062	NA	NA	0.935828104639487	NA	1.03969708260643	NA	0.719468692582687	0.693780999095913	0.709240982763661	NA	NA	0.729696402401713	NA	0.847561251566311	NA	p.Phe37Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.267	-4.292	3.025	1.307	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37E	37	F	E	missense	possibly_wt-like	0.777472948274793	0.427380946730033	3	0.246748504641102	0.293854765939119	1.26109113061047	NA	0.401946687000159	NA	NA	0.687946529978722	NA	NA	1.2425256278455	0.637103257495774	NA	0.493514181538625	NA	NA	0.637103257495774	NA	NA	0.918225625172022	p.Phe37Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.267	-4.14	2.873	1.688	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F37G	37	F	G	missense	possibly_wt-like	0.853570801129587	0.35877346093534	8	0.126845573568573	0.604958045336858	1.10218355692232	1.16788702867313	0.601474704129221	0.698974096086423	0.169561529414389	0.901826912491271	1.28073888463748	0.912338393743644	1.09576485986114	0.747981187084035	0.862765940097703	0.58549323946659	0.636865346062416	0.370058750804	0.71699567095016	0.922582957440056	0.77896670321791	0.844515314613096	p.Phe37Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.267	-3.929	2.662	1.886	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F37H	37	F	H	missense	possibly_wt-like	0.877439622234752	0.291916930902984	6	0.119174587998601	0.643861721885095	1.11101752258441	NA	0.439026855540085	0.58108007713367	NA	1.1414187340531	1.06716144284631	1.03874593930128	0.997204684534058	0.800752968776445	NA	0.510607515192647	0.579043934172494	NA	0.806492279492011	0.817316469184646	0.847048972066466	0.795013658060879	p.Phe37His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.267	-4.623	3.356	1.894	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37I	37	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe37Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.267	-3.201	1.934	11.897	5.997	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F37K	37	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe37Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.267	-4.104	2.837	3.297	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F37L	37	F	L	missense	possibly_low	0.575624600243423	0.459166408701855	4	0.229583204350928	0.125649788260305	1.02559941222654	0.979259157569635	0.898045698883656	NA	-0.0132867642622112	0.438480308782611	NA	NA	NA	0.633062832027407	0.773021228224188	0.722207476889338	NA	0.289870349805138	0.543918187165476	NA	NA	NA	p.Phe37Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.267	-2.429	1.162	9.419	9.225	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F37M	37	F	M	missense	wt-like	1.1951303364328	0.25255232202515	4	0.126276161012575	0.947633608742174	1.44262706412343	NA	NA	NA	NA	1.53187040188857	0.920656453446767	1.14556218055717	1.18243230983869	0.896311683413263	NA	NA	NA	NA	0.952340747286087	0.745108160963284	0.904579493860039	0.888043872966487	p.Phe37Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.267	-4.637	3.37	2.298	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37N	37	F	N	missense	wt-like	0.980364143388047	0.0905012460421417	7	0.0342062557669965	0.913321114038768	1.04740717273733	NA	0.837457660045747	0.932085627297784	0.957408014633967	1.07563555385601	1.10776893975769	0.992186098961933	0.960007109163199	0.776331248107033	NA	0.694277410655035	0.751195470543661	0.715570041131217	0.781919773267219	0.837330795420852	0.821972149685764	0.776331248107033	p.Phe37Asn	0	0	NA	NA	NA	NA	NA	NA	NA	7.315	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.267	-4.388	3.121	1.194	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37P	37	F	P	missense	possibly_wt-like	1.16305428446803	0.403892951972226	2	0.285595445213013	0.603297497701838	1.72281107123422	NA	1.44864972968104	NA	NA	NA	NA	NA	0.877458839255013	0.855449104301848	NA	0.976026668663923	NA	NA	NA	NA	NA	0.734871539939772	p.Phe37Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.267	-4.535	3.268	1.237	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37Q	37	F	Q	missense	possibly_wt-like	0.763770340776027	0.220945372903439	6	0.0902005707737295	0.586980470674561	0.940560210877493	0.874498144718272	NA	0.715160542548909	0.852035395914587	0.749607125531952	0.369936999873882	NA	1.02138383606856	0.664747269599689	0.723178398217563	NA	0.644804028586393	0.669358716790862	0.660135822408516	0.473673582454564	NA	0.80715758993816	p.Phe37Gln	0	0	NA	NA	NA	NA	NA	NA	NA	6.637	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.267	-4.479	3.212	1.315	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37R	37	F	R	missense	possibly_wt-like	0.78676686229995	0.183343559587246	7	0.0692973518790293	0.650946548393053	0.922587176206846	NA	0.769966439546313	0.792233644953749	0.956047103155379	0.411194749327519	0.959685467021889	0.789542069178263	0.828698562916536	0.710381785891665	NA	0.663165093852272	0.682604721440627	0.714973211304837	0.53372599856121	0.764344495871458	0.712829414136043	0.710381785891665	p.Phe37Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.267	-3.536	2.269	9.391	9.391	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37S	37	F	S	missense	possibly_wt-like	0.841096374865119	0.676807906016964	5	0.302677697112644	0.247858989600814	1.43433376012942	1.24532982016196	1.03010955929312	0.996767980048106	1.28164406549784	-0.348369550675429	NA	NA	NA	0.783086693961573	0.899611401843028	0.783086693961573	0.782919089719663	0.857764260952296	0.25	NA	NA	NA	p.Phe37Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.267	-3.939	2.672	2.344	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F37T	37	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe37Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.267	-3.936	2.669	3.617	NA	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F37V	37	F	V	missense	possibly_low	0.581470558033593	0.302627962429689	7	0.114382618337594	0.357284745634518	0.805656370432667	NA	0.72993046416897	0.806247445946809	0.864302894111922	0.184634048389215	0.173221143262451	0.480346987804158	0.831610922551623	0.644709182991125	NA	0.644709182991125	0.689477824644343	0.674738647032052	0.449097006508532	0.376717709044077	0.546298986194426	0.711844512859573	p.Phe37Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.267	-3.111	1.844	19.507	19.507	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F37W	37	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe37Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.267	-3.673	2.406	10.843	10.843	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F37X	37	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe37Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F37Y	37	F	Y	missense	possibly_wt-like	0.751255198634222	0.253418993843137	6	0.103457871007533	0.548481497542267	0.954028899726177	0.702872957947545	0.855511358219719	NA	NA	0.329686155305917	1.01228555048113	0.635419389375617	0.971755780475408	0.672061512992309	0.64152316430716	0.702599861677458	NA	NA	0.503279455417977	0.79026964049937	0.629819957100117	0.782231995445517	p.Phe37Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	96.5	21.2	0.468	41.4	-134.3	-69.7	121.4	3.50877192982456	-5.6	0	0	46.46	0	0	0	0	6	10.4825969043935	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.267	-1.609	0.342	12.759	12.759	72.46	0.003216399	0	0.091930028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
P38A	38	P	A	missense	wt-like	0.871090202682648	0.0931122338462123	8	0.0329201459820421	0.806567902192044	0.935612503173251	0.832290828505966	0.92080524503663	0.834732712120183	0.985124130688891	0.78425468643642	1.02184376868879	0.77918396495457	0.810486285029731	0.705349550608826	0.703097148239666	0.732699244632735	0.703448493579336	0.727724986543364	0.673077997041121	0.794980625218831	0.707250607638315	0.701234704710099	p.Pro38Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-0.666	-3.283	2.617	3.701	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P38C	38	P	C	missense	possibly_wt-like	0.832771498600659	0.218184902331434	8	0.0771400119955409	0.681579853322411	0.983963143878907	0.941016013389728	1.1342754852695	0.813535291814331	0.647503674927579	0.420190947297757	0.824578969538872	0.905889630587941	0.975181975979561	0.72629011561939	0.754826038216027	0.831105432770091	0.693052166595186	0.57966101532638	0.537086418807857	0.697754193022752	0.775493441989948	0.783952795480262	p.Pro38Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-0.666	-5.282	4.616	0.621	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38D	38	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro38Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-0.666	-3.643	2.977	2.502	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38E	38	P	E	missense	possibly_low	0.690723237322958	0.276791246309267	6	0.11299955312112	0.469248182936441	0.912198291709475	NA	0.78035127293124	0.892433395709503	0.825650411260652	0.137891646088855	0.718586139839648	NA	0.78942655810785	0.662869934188362	NA	0.667952327270557	0.731747935924119	0.657787541106167	0.43163695109549	0.645513221929931	NA	0.690657497783358	p.Pro38Glu	0	0	NA	NA	NA	NA	NA	NA	NA	10.0355	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-0.666	-3.607	2.941	4.247	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P38F	38	P	F	missense	possibly_wt-like	0.779743401753261	0.151160474537855	6	0.0617110053157855	0.658792053884562	0.900694749621961	0.59404955970733	0.789269809874021	0.84976019897796	0.923028162083654	NA	0.924810297113548	NA	0.597542382763055	0.686278163257479	0.58974754672196	0.672063622706135	0.710818761511437	0.700492703808823	NA	0.747155477065101	NA	0.594284043553984	p.Pro38Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-0.666	-4.684	4.018	1.469	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38G	38	P	G	missense	possibly_wt-like	0.780294346214196	0.279563089449899	7	0.105664915776762	0.573194916862284	0.987393775566109	0.818540411446015	0.802499034067373	0.895596874233701	1.11603322573047	0.200019711128733	0.784043443170291	NA	0.845327723722794	0.696555022678015	0.696555022678015	0.678162072417262	0.733299471755855	0.785135371931803	0.454844133544753	0.677775339101572	NA	0.718733749595577	p.Pro38Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-0.666	-3.522	2.856	2.716	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P38H	38	P	H	missense	possibly_low	0.620797543368032	0.244447815942675	5	0.109320386679835	0.406533522699562	0.835061564036502	NA	0.995637404577218	0.601233918961648	0.695537465427111	0.412433165269099	0.399145762605084	NA	NA	0.588928435522532	NA	0.767195610788704	0.588928435522532	0.600726308179942	0.534188593761718	0.488069783912982	NA	NA	p.Pro38His	1	0	NA	NA	NA	NA	NA	NA	NA	10.452	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-0.666	-4.794	4.128	1.956	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P38I	38	P	I	missense	possibly_low	0.68473266990327	0.430035829970084	3	0.248281302194412	0.198110259567516	1.17135508023902	NA	NA	0.902326938208403	NA	NA	0.189386229893579	NA	0.962484841607828	0.736600248203918	NA	NA	0.736600248203918	NA	NA	0.384685038775777	NA	0.777575684413028	p.Pro38Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-0.666	-4.205	3.539	1.961	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38K	38	P	K	missense	wt-like	0.96271311969749	0.0558222632953659	4	0.027911131647683	0.908008306900276	1.01741793249471	NA	0.883919670625269	0.993180947437235	0.964028652016068	NA	NA	NA	1.00972320871139	0.749816676301047	NA	0.715695615597047	0.781159820743186	0.718473531858908	NA	NA	NA	0.801301062505021	p.Pro38Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-0.666	-3.587	2.921	9.83	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P38L	38	P	L	missense	possibly_low	0.627175442185471	0.128315660892477	7	0.0484987611480557	0.532119617040471	0.72223126733047	0.428067032056837	0.802479537266597	0.609663898467138	0.707363998745189	0.501826590433507	NA	0.703771518517867	0.63705551981116	0.605912852593716	0.510776957524894	0.678153084720227	0.593062939728432	0.605912852593716	0.56758041960119	NA	0.666633962245973	0.614129439861011	p.Pro38Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-0.666	-3.764	3.098	3.815	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	1	0	1	0	0	2	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.49	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P38M	38	P	M	missense	possibly_wt-like	0.713344066879137	0.347204543844551	4	0.173602271922276	0.373089866277147	1.05359826748113	NA	0.19486842341438	0.864426953505645	NA	0.861535266713212	NA	NA	0.93254562388331	0.709978662249484	NA	0.39805458706143	0.718012107384	NA	0.701945217114968	NA	NA	0.762538770483818	p.Pro38Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-0.666	-4.886	4.22	1.266	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38N	38	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro38Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-0.666	-3.071	2.405	8.645	8.645	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38P	38	P	P	synonymous	wt-like	1.19244499635198	0.0283553968448751	2	0.0200502933922468	1.15314714342371	1.23174284928024	1.17239470295973	NA	NA	NA	NA	NA	NA	1.21249528974422	0.884026765944286	0.864910585677934	NA	NA	NA	NA	NA	NA	0.903142946210637	p.Pro38=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P38Q	38	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro38Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-0.666	-4.05	3.384	3.92	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38R	38	P	R	missense	wt-like	0.861585082162026	0.157634194025488	7	0.059580125073078	0.744810182824402	0.978359981499651	0.997465010953618	0.779410967830497	0.884197527912262	0.991330759572835	0.551711933164853	NA	0.964088534079647	0.862890841620472	0.727708634283498	0.781683145770088	0.667518862444035	0.727708634283498	0.730446913206115	0.586214482155163	NA	0.806838986883918	0.727554791433944	p.Pro38Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-0.666	-3.111	2.445	28.001	28.001	81.39	0.000675526	0	0.019307659	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Mar 21, 2017)	criteria provided, single submitter	0	1	0	0	0	1	0	0	0	0	1	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P38S	38	P	S	missense	wt-like	1.13611952068973	0.262707164665255	4	0.131353582332628	0.878671230077466	1.393567811302	0.947077657100195	1.0971419816967	0.981994307817499	1.51826413614454	NA	NA	NA	NA	0.794830409179975	0.75771002595916	0.813987512563516	0.775673305796435	0.961534357614812	NA	NA	NA	NA	p.Pro38Ser	1	0	NA	NA	NA	NA	NA	NA	NA	5.886	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-0.666	-3.549	2.883	3.573	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	12	0	0	0	0	0	0	8	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.49	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P38T	38	P	T	missense	possibly_wt-like	0.886312499227035	0.187459621742287	4	0.0937298108711437	0.702605445641842	1.07001955281223	NA	NA	NA	NA	1.13212332298426	0.677665597444887	0.848029521723776	0.887431554755217	0.742105343283169	NA	NA	NA	NA	0.803020091834516	0.625344604124241	0.744330369643918	0.739880316922421	p.Pro38Thr	1	0	NA	NA	NA	NA	NA	NA	NA	4.044	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-0.666	-3.602	2.936	2.807	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 6, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P38V	38	P	V	missense	possibly_wt-like	0.79618040024161	0.285881356610703	8	0.101074322937119	0.598078367523087	0.994282432960134	0.968155415202727	1.06705781150344	0.818713365761443	0.922802972617947	0.517604051984823	0.22275427210329	1.00487067666515	0.847484636094073	0.710105500632336	0.767738328334547	0.800119216407739	0.695591765712699	0.700393946621574	0.573473898314435	0.401131235499161	0.828803979428291	0.719817054643097	p.Pro38Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-0.666	-3.746	3.08	2.493	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P38W	38	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro38Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-0.666	-5.728	5.062	0.419	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P38X	38	P	X	nonsense	low	-0.0274945396175169	0.106371186506055	8	0.0376078936506451	-0.101204656707194	0.0462155774721602	-0.100171181822441	-0.075949243000173	0.0886827177628152	0.00632040598701155	-0.217220566864555	0.0392994949692617	-0.0580841909359533	0.0971662469638986	0.298729105521994	0.259453618996807	0.273212200586211	0.337546436821912	0.298469104536634	0.298989106507354	0.310711386002786	0.256303510800006	0.342971101596891	p.Pro38Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P38Y	38	P	Y	missense	wt-like	0.912021542565524	0.0454270825973377	2	0.0321217981540989	0.849063975064825	0.974979110066223	NA	NA	0.944143340719622	NA	NA	NA	NA	0.879899744411425	0.746603342796673	NA	NA	0.757109205781528	NA	NA	NA	NA	0.736097479811817	p.Pro38Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.1	99.7	20	0.566	37	-155.7	-74.6	86	0	-0.4	0	0	49.74	0	0	0	0	6	14.2949060108837	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-0.666	-4.555	3.889	1.461	NA	81.39	0.000675526	0	0.019307659	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39A	39	A	A	synonymous	wt-like	0.941829387781626	0.15265044729692	7	0.0576964458672033	0.828746431845943	1.05491234371731	NA	1.06969704671189	0.93919927625873	1.1142888451967	0.766058185469206	0.926812833041034	0.719736351735084	1.05701317605874	0.754684377192742	NA	0.801335859421674	0.754684377192742	0.784370371160269	0.666280915599533	0.74814247233447	0.675232515935328	0.825052356719193	p.Ala39=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A39C	39	A	C	missense	wt-like	1.0766618793228	0.0764042957265308	2	0.0540259956200123	0.970772873678654	1.18255088496694	NA	NA	1.13068787494281	NA	NA	NA	NA	1.02263588370278	0.828193430178031	NA	NA	0.848600431926386	NA	NA	NA	NA	0.807786428429677	p.Ala39Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.194	-4.928	3.734	1.321	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39D	39	A	D	missense	wt-like	0.89624189292703	0.225026101826212	8	0.0795587412726444	0.740309625377306	1.05217416047675	1.20504268179107	0.881051246764263	0.988108170917767	0.909386580794622	0.519095634023943	1.11818417690875	0.653842153607894	0.89522449860793	0.72908381415096	0.88044372739411	0.714373320471432	0.778671865008339	0.694510167310024	0.574031060629046	0.842464181372312	0.639742336194358	0.743794307830488	p.Ala39Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.194	-3.844	2.65	3.549	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39E	39	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.194	-3.733	2.539	3.74	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A39F	39	A	F	missense	wt-like	1.01573299455786	0.120158846304153	6	0.0490546435877804	0.919587659851357	1.11187832926435	1.03228776498745	1.08567089862969	1.01763179852503	1.08389217537002	1.09576438781589	NA	0.779150942019051	NA	0.791295227521252	0.79825099446141	0.808699536322894	0.793151800865375	0.771039864760231	0.78943865417713	NA	0.707232821703431	NA	p.Ala39Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.194	-4.435	3.241	1.512	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39G	39	A	G	missense	wt-like	1.00501395623524	0.185727490403765	8	0.0656645839586308	0.87631373661652	1.13371417585397	0.605272650545842	0.983145525004207	1.04628738040591	1.09476285514638	1.19546065100581	1.18396222080431	0.969821188661285	0.96139917830819	0.792118206844378	0.595087229811953	0.761437064538369	0.807206001558491	0.775807218130117	0.826678979750977	0.874884382808972	0.809926556765298	0.777030412130266	p.Ala39Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.194	-2.119	0.925	17.965	17.965	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A39H	39	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.194	-4.939	3.745	1.399	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39I	39	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.194	-3.997	2.803	6.193	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39K	39	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.194	-3.729	2.535	3.927	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39L	39	A	L	missense	low	0.522748270876499	0.262842202294154	8	0.0929287518121012	0.34061126419652	0.704885277556479	0.89856630914341	0.677683196064197	0.537658148559517	0.454859024419983	0.395535687790544	0.0886306116740413	0.334967408439745	0.794085780920557	0.542812144558044	0.734629465703095	0.620624071693305	0.557747542383976	0.495176406941074	0.527876746732112	0.335025346192962	0.46799850528789	0.69299758338801	p.Ala39Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.194	-3.596	2.402	4.903	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39M	39	A	M	missense	possibly_wt-like	0.818996305058285	0.17582339431507	2	0.124325914411423	0.575321990466887	1.06267061964968	NA	0.694670390646862	0.943322219469707	NA	NA	NA	NA	NA	0.692580683675776	NA	0.62845488250892	0.756706484842632	NA	NA	NA	NA	NA	p.Ala39Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.194	-4.853	3.659	1.196	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39N	39	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.194	-3.897	2.703	3.984	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39P	39	A	P	missense	possibly_low	0.68327531602677	0.0971121751326483	5	0.0434298850078932	0.598154305558583	0.768396326494956	0.582298217851816	0.733802890617672	0.579461413772016	0.79430215771847	NA	NA	NA	0.726511900173874	0.64403971620111	0.584156534202015	0.646494306412748	0.57825005674108	0.64403971620111	NA	NA	NA	0.659058733081362	p.Ala39Pro	1	0	NA	NA	NA	NA	NA	NA	NA	8.192	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.194	-4.037	2.843	2.11	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A39Q	39	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.194	-4.183	2.989	2.397	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39R	39	A	R	missense	possibly_low	0.696042182917223	0.248535231384844	8	0.0878704737379953	0.52381921908628	0.868265146748166	0.911983149596451	0.712026717049766	0.48224683530679	0.450342697211998	0.590748808780657	0.953358820394579	0.418162335778646	1.0494680992189	0.618626044375562	0.741012883347937	0.63645585688134	0.530570927357972	0.493195764683419	0.600796231869783	0.76122626452968	0.512806743474434	0.821262856536727	p.Ala39Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.194	-3.361	2.167	7.939	7.939	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.755	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39S	39	A	S	missense	possibly_low	0.702506985504866	0.131484533128525	2	0.0929736049963273	0.520282068199211	0.88473190281052	0.795480590501193	NA	0.609533380508538	NA	NA	NA	NA	NA	0.63929131410881	0.685583701343362	NA	0.592998926874257	NA	NA	NA	NA	NA	p.Ala39Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.194	-1.599	0.405	15.935	15.935	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	0.915	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
A39T	39	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.194	-2.715	1.521	6.529	6.529	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.275	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A39V	39	A	V	missense	wt-like	0.973750031845178	0.198286860834451	8	0.0701049919581168	0.836346772470799	1.11115329121956	1.10008339015246	1.07032619129159	1.02386064308645	1.21072840833554	0.904502647050471	0.542286840445202	0.957529380924031	0.980682753475674	0.798916318751357	0.830506560996327	0.801625884484689	0.796206753018025	0.826664090208094	0.717995159024693	0.558620111995181	0.803306270331361	0.786715550289485	p.Ala39Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.194	-3.114	1.92	10.155	10.155	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A39W	39	A	W	missense	possibly_wt-like	0.719033177936859	0.0716134330768575	2	0.0506383441526949	0.619783847160832	0.818282508712885	NA	NA	NA	NA	NA	0.769671522089553	NA	0.668394833784164	0.650280680554433	NA	NA	NA	NA	NA	0.670691811698278	NA	0.629869549410588	p.Ala39Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.194	-5.617	4.423	0.364	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A39X	39	A	X	nonsense	low	0.0661377597389904	0.13064798586771	8	0.0461910383777111	-0.0243950118898308	0.156670531367812	0.181887354301048	-0.0795458467656927	-0.0691153396913842	-0.0573112797096672	0.139325717236026	0.201047922179251	-0.00433415926857185	0.217147709630913	0.337842845572982	0.393650447428271	0.271554226779561	0.260153990991854	0.270563330704784	0.432172630916458	0.390432768422377	0.285252922723588	0.403231558093293	p.Ala39Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A39Y	39	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala39Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	98.4	16.5	0.475	25.3	-160	-75.2	133.6	0.826446280991736	-6	0	0	61.27	0	0	0	0	9	15.0641308365269	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.194	-4.524	3.33	1.304	NA	72.46	0.003029071	0	0.086575891	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40A	40	E	A	missense	possibly_wt-like	1.28508784762064	0.529441082662377	2	0.374371379789315	0.551333426391022	2.01884226885027	NA	NA	NA	NA	1.65945922740996	NA	NA	0.91071646783133	0.875787559635756	NA	NA	NA	NA	1	NA	NA	0.751575119271512	p.Glu40Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.959	-2.761	0.802	10.71	10.71	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.065	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E40C	40	E	C	missense	possibly_wt-like	0.756005919995118	0.307941154558813	4	0.153970577279407	0.45422913384864	1.0577827061416	NA	0.47588905097779	0.523001124930091	NA	1.11276567445155	NA	NA	0.912367829621042	0.651481740788083	NA	0.527600366914937	0.550558969054425	NA	0.795789277853766	NA	NA	0.752404512521742	p.Glu40Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.959	-5.399	3.44	0.792	NA	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E40D	40	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.959	-2.468	0.509	34.455	34.455	86.85	0.00363808	0	0.103982392	4.068e-06	1	245836	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.26	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
E40F	40	E	F	missense	possibly_low	0.65838268305463	0.167926202126254	5	0.0750988806315348	0.511191581737549	0.805573784371711	NA	0.875721394839895	0.477434333906148	NA	0.618678732808909	NA	0.535066433474505	0.785012520243692	0.611229115016903	NA	0.711916348433356	0.528210624196037	NA	0.611229115016903	NA	0.575770518094979	0.688440555842712	p.Glu40Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.959	-3.881	1.922	8.226	8.226	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40G	40	E	G	missense	wt-like	0.806258656663106	0.14227912076788	8	0.0503032655581137	0.707666067864449	0.904851245461763	0.812467368467142	0.850938520411459	0.840073041238801	0.956067955724182	0.863662393943413	0.473580553268775	0.80132492969145	0.851954490559626	0.704403725372425	0.693665611430642	0.700491860406694	0.706067671145241	0.714982356231023	0.70273977959961	0.524756659415755	0.719175584957769	0.72206203036334	p.Glu40Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.959	-2.706	0.747	18.471	18.471	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.67	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E40H	40	E	H	missense	wt-like	1.01217333374671	0.0273493815485204	3	0.015790172799208	0.981225163750601	1.04312150374282	NA	1.03277165568072	0.981143265389683	1.02260508016974	NA	NA	NA	NA	0.775255909942161	NA	0.784313875594347	0.775255909942161	0.744162314704074	NA	NA	NA	NA	p.Glu40His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.959	-4.988	3.029	1.545	NA	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40I	40	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.959	-3.35	1.391	9.096	9.096	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.41	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40K	40	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.959	-3.048	1.089	8.525	8.525	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.665	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
E40L	40	E	L	missense	possibly_wt-like	0.745650612783614	0.167032609663442	7	0.063132392286799	0.621913397643634	0.869387827923594	0.844604538353505	0.686642557156989	0.501388436393191	0.76914901774928	0.836328116040664	NA	0.588700658213741	0.992740965577929	0.633008767901437	0.708955722245175	0.624754186374986	0.539958972743827	0.633008767901437	0.692529392812241	NA	0.604657557172211	0.792771763888322	p.Glu40Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.959	-3.433	1.474	11.554	11.554	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.41	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40M	40	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.959	-4.103	2.144	8.32	8.32	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40N	40	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.959	-3.112	1.153	9.352	9.352	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.015	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E40P	40	E	P	missense	wt-like	0.957156331697658	0.189196357819754	7	0.0715095016786087	0.817000283855179	1.09731237954014	0.593035301533156	0.845219548428641	1.01384624676391	1.10338093705873	0.973087778255645	NA	1.00918078468388	1.16234372515964	0.779586691235023	0.589264986498627	0.697855510570391	0.791295167682842	0.779586691235023	0.743614299942142	NA	0.831125375129815	0.877954420344247	p.Glu40Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.959	-3.492	1.533	13.136	13.136	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40Q	40	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.959	-3.066	1.107	6.795	6.795	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.065	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E40R	40	E	R	missense	low	0.564691372503094	0.16075518763913	7	0.0607597497795231	0.445604451225563	0.683778293780625	0.60189579075757	0.267376881852212	0.744299319842094	0.466801862824103	0.538911706769754	0.635757794482684	NA	0.697796250993243	0.593480599217212	0.593480599217212	0.431479766115894	0.65909521365926	0.500413957129582	0.581433113394486	0.60468939254696	NA	0.644636354075884	p.Glu40Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.959	-4.212	2.253	3.298	NA	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E40S	40	E	S	missense	possibly_low	0.551722195251566	0.215554701483562	4	0.107777350741781	0.340482469448533	0.762961921054598	NA	NA	0.589193188494443	0.242090822407354	NA	0.738201737719867	NA	0.637403032384598	0.598663503496187	NA	NA	0.583023029616582	0.401866584028687	NA	0.655181214422789	NA	0.614303977375792	p.Glu40Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.959	-1.892	-0.067	8.568	8.568	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.935	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E40T	40	E	T	missense	wt-like	1.15874510519402	0.350048638032957	5	0.156546510014582	0.851919583660003	1.46557062672804	NA	1.35203645928999	0.878493708631787	1.08956874010032	1.65945922740996	NA	0.81416739053806	NA	0.773529330971465	NA	0.93148957697238	0.724911182072677	0.773529330971465	1	NA	0.726092449518178	NA	p.Glu40Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.959	-2.486	0.527	9.275	9.275	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E40V	40	E	V	missense	wt-like	0.861452778285967	0.128979532412299	7	0.048749680997191	0.765905159273656	0.957000397298277	1.02468860384277	0.86238861653414	0.699014525433801	1.01161068945389	0.769228813676931	NA	0.915131276633016	0.748106922427219	0.705770162019181	0.794635492025739	0.705770162019181	0.636885174735388	0.739340707711013	0.667465265172439	NA	0.780470931489236	0.669904791048234	p.Glu40Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.959	-2.95	0.991	9.42	9.42	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.41	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E40W	40	E	W	missense	possibly_low	0.484261044950179	0.204054738400669	3	0.117811058145045	0.253355614005337	0.71516647589502	0.270957316921673	NA	NA	NA	NA	0.677598986108465	NA	0.504226831820398	0.547416489408358	0.436027844178865	NA	NA	NA	NA	0.625311773215675	NA	0.547416489408358	p.Glu40Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.959	-3.947	1.988	15.648	15.648	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E40X	40	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu40Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	3	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E40Y	40	E	Y	missense	wt-like	0.887517226329769	0.125292555765855	7	0.0473561348120207	0.794700907651185	0.980333545008353	0.834616810181121	0.806342993999379	0.851728395694304	0.963951352385417	1.14093300720181	NA	0.825706897199346	0.789341127647004	0.711784068437327	0.704203795704002	0.679934073253766	0.711784068437327	0.718439631986751	0.806310842139164	NA	0.732307551563136	0.690614590500392	p.Glu40Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	99.8	14.2	0.909	98.5	15.9	-72.7	-45.1	46.7289719626168	-0.9	0	0	82.42	0	0	0	0	4	18.5718307622054	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.959	-3.887	1.928	8.663	8.663	86.85	0.00363808	0	0.103982392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R41A	41	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.476	-3.172	0.696	20.988	20.988	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.205	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
R41C	41	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.476	-3.819	1.343	11.753	11.753	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41D	41	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.476	-2.714	0.238	13.29	13.29	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.185	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
R41E	41	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.476	-3.215	0.739	6.855	6.855	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R41F	41	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.476	-3.828	1.352	14.538	14.538	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.295	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41G	41	R	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.476	-1.517	-0.959	19.989	19.989	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	-1.605	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
R41H	41	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.476	-3.303	0.827	11.86	11.86	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41I	41	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.476	-3.536	1.06	10.646	10.646	43.18	0.003382571	0	0.096679515	0	NA	NA	not specified	Uncertain significance(Last reviewed: Dec 11, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R41K	41	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.476	-2.174	-0.302	15.194	15.194	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-1.73	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
R41L	41	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.476	-3.924	1.448	6.571	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.125	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
R41M	41	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.476	-4.063	1.587	3.698	3.698	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.75	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41N	41	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.476	-2.426	-0.05	13.439	13.439	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.735	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R41P	41	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.476	-4.316	1.84	2.106	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.405	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41Q	41	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.476	-4.242	1.766	2.92	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.1	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
R41S	41	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.476	-2.608	0.132	10.969	10.969	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	-0.69	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
R41T	41	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.476	-3.918	1.442	4.097	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	-0.375	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
R41V	41	R	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.476	-4.044	1.568	6.911	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.295	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R41W	41	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.476	-5.68	3.204	0.737	NA	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.75	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R41X	41	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R41Y	41	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg41Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	98.5	11.2	0.7	94	-145	-130.9	78.8	75.0943396226415	-0.6	0	0	98.98	0	0	0	0	4	18.8806111622479	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.476	-3.575	1.099	8.506	8.506	43.18	0.003382571	0	0.096679515	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L42A	42	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.013	-2.934	0.921	8.841	8.841	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L42C	42	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.013	-5.318	3.305	0.931	NA	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L42D	42	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.013	-4.298	2.285	2.326	NA	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.02	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L42E	42	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.013	-4.059	2.046	3.204	NA	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.75	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L42F	42	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.013	-2.482	0.469	16.356	16.356	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.425	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L42G	42	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.013	-3.368	1.355	14.802	14.802	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L42H	42	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.013	-5.132	3.119	1.894	NA	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L42I	42	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.013	-2.477	0.464	14.823	14.823	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.74	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
L42K	42	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.013	-2.488	0.475	8.457	8.457	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.75	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L42M	42	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.013	-2.866	0.853	5.426	5.426	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
L42N	42	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.013	-4.34	2.327	1.76	NA	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L42P	42	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.013	-3.598	1.585	35.847	35.847	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L42Q	42	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.013	-3.455	1.442	6.636	6.636	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L42R	42	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.013	-2.637	0.624	13.488	13.488	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	7	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.09	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L42S	42	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.013	-2.86	0.847	7.04	7.04	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L42T	42	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.013	-2.974	0.961	7.75	7.75	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.895	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L42V	42	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.013	-2.407	0.394	13.428	13.428	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	2	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.145	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
L42W	42	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.013	-3.948	1.935	11.459	11.459	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L42X	42	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L42Y	42	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu42Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	97.7	12.3	0.106	33.5	145.5	-42.4	154.2	37.17277486911	-1.1	0	0	4.1	0	0	0	0	6	16.5333655938529	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.013	-3.415	1.402	12.759	12.759	72.46	0.003777616	0	0.107970544	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.365	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
E43A	43	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.388	-3.091	1.703	6.325	6.325	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43C	43	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.388	-5.451	4.063	1.325	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43D	43	E	D	missense	wt-like	1.02127546020493	0.240772609021116	7	0.0910034922837228	0.842911892861463	1.19963902754839	1.08925524988062	1.08552405932548	1.10956711516741	1.26270223403619	0.506781881911709	0.988756686990107	NA	1.10634099412298	0.825354786112064	0.825354786112064	0.808631845874895	0.838241703288161	0.849457291571516	0.569431408415184	0.778672906258296	NA	0.849827157496314	p.Glu43Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.388	-3.154	1.766	9.155	9.155	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43E	43	E	E	synonymous	wt-like	1.05073431709168	0.284915114315638	7	0.107687791034674	0.839670125089046	1.26179850909432	0.635131605514553	0.838105381625472	1.05678415538077	NA	1.56027884354112	1.08062306561662	1.14277333473372	1.04144383322951	0.817232684534985	0.609293419463751	0.69457599940242	0.812354170691483	NA	0.962952374867065	0.823951335410989	0.903077439925744	0.817232684534985	p.Glu43=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E43F	43	E	F	missense	possibly_wt-like	0.84495300373645	0.199672133758171	4	0.0998360668790857	0.64927790829531	1.04062809917759	0.706277692562042	1.07448693914992	0.947108529529895	NA	0.65193885370394	NA	NA	NA	0.70085327351225	0.643143057089687	0.803543919223828	0.758563489934814	NA	0.623653028322429	NA	NA	NA	p.Glu43Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-1.99	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.388	-4.54	3.152	2.065	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43G	43	E	G	missense	wt-like	1.02614380596145	0.158558577000198	7	0.0599295089969728	0.908684126716212	1.14360348520668	1.03293624219844	1.05302363538139	0.846542260940255	0.914325809426046	1.28686309691472	NA	1.16129111645624	0.888024480413046	0.79364969740447	0.798559524691413	0.79364969740447	0.709240515877204	0.696676273638706	0.860821250834992	NA	0.913050994812439	0.74017811268199	p.Glu43Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.388	-3.223	1.835	15.688	15.688	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43H	43	E	H	missense	wt-like	1.00279081152315	0.285401098215896	6	0.116514510443148	0.774426567378261	1.23115505566804	1.15188584180465	1.1577851037762	1.13553316820451	1.22247068599962	NA	0.474994456027636	NA	0.874075613326266	0.836878327710061	0.855152951111799	0.84194297124517	0.850976817937319	0.831813684174953	NA	0.525453533471891	NA	0.733172321290783	p.Glu43His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.388	-2.927	1.539	10.191	10.191	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43I	43	E	I	missense	possibly_wt-like	0.833315064251571	0.233351402559352	6	0.0952653111722003	0.646598485378057	1.02003164312508	1.24871344053932	0.733598819301552	0.634731410890493	NA	0.960570046772752	0.664869337550786	NA	0.757407330454527	0.660488067939692	0.901221248967308	0.646400232970446	0.605357362921074	NA	0.738938453717285	0.619037677088507	NA	0.674575902908937	p.Glu43Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.388	-4.261	2.873	4.341	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43K	43	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.388	-2.985	1.597	16.226	16.226	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43L	43	E	L	missense	possibly_low	0.683483374230354	0.19159756501074	7	0.0724170726891353	0.54154851989383	0.825418228566879	0.80667649473653	0.638982337780499	0.812352400992565	0.793261575441053	0.300131648146236	NA	0.604006183578272	0.828972978937325	0.643583367239596	0.690910449685937	0.602783627342897	0.692472014878978	0.643583367239596	0.492239729017155	NA	0.61290101200823	0.710519610804907	p.Glu43Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.388	-3.28	1.892	14.163	14.163	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43M	43	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.388	-3.179	1.791	4.622	4.622	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43N	43	E	N	missense	possibly_wt-like	0.719964318449174	0.339804408927042	8	0.120139000914699	0.48449620351774	0.955432433380609	0.726553639210962	1.20537990249124	0.995532524088372	1.01522962004643	0.172126981969162	0.512889621253849	0.46837145418854	0.663630804344837	0.640133350642125	0.652789876402892	0.863883372453331	0.782313157302106	0.74092779529989	0.444425144088079	0.544131025494304	0.539849042912744	0.627476824881359	p.Glu43Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.388	-3.346	1.958	6.68	6.68	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43P	43	E	P	missense	possibly_wt-like	0.808752324395194	0.326572628007339	8	0.115460859906951	0.582453197353546	1.03505145143684	0.982677661679688	0.769837245420481	0.983413994096514	1.12277900289897	0.723173076977015	0.166715808402581	0.57722384287041	1.14419796281589	0.71887660487196	0.774647672209376	0.663105537534543	0.776369594427721	0.788093742905688	0.650261705336089	0.373511407152449	0.598476220256895	0.868840746464936	p.Glu43Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.388	-4.153	2.765	1.924	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43Q	43	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.388	-2.282	0.894	15.448	15.448	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43R	43	E	R	missense	wt-like	1.08331451952529	0.159550307646908	5	0.0713530667458981	0.943465078516843	1.22316396053373	1.3497315578083	1.00044219560894	1.08944479849296	0.933917603626929	NA	NA	NA	1.0430364420893	0.818032569240318	0.949283297143297	0.769410538591814	0.828372663527295	0.705268285180505	NA	NA	NA	0.818032569240318	p.Glu43Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.388	-2.6	1.212	9.903	9.903	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43S	43	E	S	missense	wt-like	1.03401968866056	0.0605353165409819	4	0.030267658270491	0.974696168554032	1.09334320876709	NA	1.08384054461892	0.955108643619065	1.01805754326027	NA	NA	NA	1.07907202314398	0.785171469758394	NA	0.807855773927981	0.762487165588807	0.742167985383734	NA	NA	NA	0.83613136980666	p.Glu43Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.388	-2.895	1.507	6.692	6.167	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43T	43	E	T	missense	possibly_wt-like	0.802860686598145	0.189155907790796	2	0.133753425100369	0.540708790592546	1.06501258260374	0.936614111698514	NA	NA	NA	NA	NA	NA	0.669107261497776	0.691479540799249	0.752731716753019	NA	NA	NA	NA	NA	NA	0.630227364845478	p.Glu43Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.388	-2.969	1.581	17.818	17.818	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43V	43	E	V	missense	wt-like	0.923544945637486	0.258083785086042	8	0.0912463972743159	0.744705293260793	1.10238459801418	1.05008527985964	0.691338577863702	0.550955714398692	0.735524320649265	1.37040362473798	1.04354401640278	0.933760361352355	1.01274766983547	0.796662262831293	0.80671863413165	0.626918972888823	0.564269366292858	0.618262605165621	0.892026798116366	0.805676084682932	0.790504433434627	0.802820092227959	p.Glu43Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.388	-3.882	2.494	5.183	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E43W	43	E	W	missense	possibly_low	0.532250079024034	0.380826249953086	4	0.190413124976543	0.159047211886286	0.905452946161783	NA	NA	NA	0.0361185020968125	0.479611977476972	0.940041264802177	0.673228571720176	NA	0.604733077118688	NA	NA	NA	0.311537105510608	0.559282421335975	0.754662405080848	0.650183732901401	NA	p.Glu43Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.388	-3.986	2.598	13.307	13.307	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E43X	43	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu43Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E43Y	43	E	Y	missense	wt-like	1.01340582060526	0.0674139315757773	2	0.0476688481636781	0.91997659501994	1.10683504619057	NA	NA	NA	NA	NA	1.06107466876893	NA	0.965736972441579	0.796762762638542	NA	NA	NA	NA	NA	0.814316464471806	NA	0.779209060805277	p.Glu43Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	94.8	10.8	0.854	53.4	-8.2	174.1	153	58.8785046728972	-3.5	0	0	4.19	0	0	0	0	4	15.9511152544266	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.388	-4.409	3.021	1.825	NA	72.21	0.001890854	0	0.054043749	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44A	44	G	A	missense	possibly_low	0.673005256577797	0.198837208298451	7	0.0751534006491499	0.525707297989754	0.82030321516584	0.508660926521593	0.821993778894085	0.695629187795005	0.872238656151623	0.306219258288889	0.738528003635584	NA	0.767766984757801	0.655342021982319	0.549121640074673	0.687148821694418	0.635224827554606	0.678218887705211	0.494513681685242	0.655342021982319	NA	0.679779019153592	p.Gly44Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.82	-2.117	0.297	20.988	20.988	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.375	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G44C	44	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.82	-5.304	3.484	1.553	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G44D	44	G	D	missense	possibly_wt-like	0.799232297703555	0.189910585079917	6	0.0775306716998681	0.647274973474615	0.951189621932495	1.07663919399744	0.9227461150433	0.672134134214328	0.884797040827852	0.613836864858706	NA	NA	0.625240437279709	0.653714003666656	0.819352362962227	0.733593953041824	0.623701620673275	0.683726386660036	0.609420494181158	NA	NA	0.608195337616702	p.Gly44Asp	1	0	NA	NA	NA	NA	NA	NA	NA	2.406	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.82	-3.941	2.121	3.537	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	3	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G44E	44	G	E	missense	wt-like	0.84941853267091	0.0569025590636817	4	0.0284512795318408	0.793655049474421	0.9051820158674	NA	0.876494924049915	0.771487081020864	0.846437059127937	NA	NA	NA	0.903255066484924	0.692351225227889	NA	0.71227293238102	0.672429518074758	0.666903557564883	NA	NA	NA	0.747827644943039	p.Gly44Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.82	-3.193	1.373	7.224	7.224	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.155	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G44F	44	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.82	-3.2	1.38	10.617	10.617	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44G	44	G	G	synonymous	wt-like	1.0375822908178	0.0863469289845733	8	0.0305282495098125	0.977748021267512	1.09741656036808	1.12900217007427	1.00187514731436	0.96536608205257	0.986870379042659	1.1452984487562	1.09822844414101	1.07178793712186	0.902229718039441	0.789006302453031	0.844265437437191	0.770071105212067	0.767517951525767	0.728490806450238	0.807941499693995	0.832628545682486	0.864845173780454	0.747312665678582	p.Gly44=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G44H	44	G	H	missense	wt-like	1.09323189300111	0.170490272514591	2	0.12055482782141	0.856948772308716	1.3295150136935	1.21378672082252	0.972677065179696	NA	NA	NA	NA	NA	NA	0.820607608292049	0.884603935845265	0.756611280738832	NA	NA	NA	NA	NA	NA	p.Gly44His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.82	-3.964	2.144	7.028	7.028	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44I	44	G	I	missense	possibly_low	0.561498907008497	0.224121744064339	6	0.0914973188700459	0.38216745734123	0.740830356675764	NA	0.749465338444545	0.650488607356696	0.741590931589434	0.146533999996528	NA	0.505904978572476	0.575009586091302	0.598026254467505	NA	0.653714431268847	0.613085518727416	0.620923126743333	0.43486519719969	NA	0.560064351157739	0.582966990207594	p.Gly44Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.82	-3.639	1.819	7.479	7.479	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44K	44	G	K	missense	possibly_wt-like	0.857784389712372	0.473224563346967	6	0.193193118991907	0.479132834427272	1.23643594499747	NA	0.826076966423171	0.568153097822032	0.709791398374188	1.65370547576709	0.290699421014327	NA	1.09827997887342	0.64800424743461	NA	0.689031102427082	0.572703865338551	0.606977392442138	0.997850756110656	0.434619543814275	NA	0.845778528250051	p.Gly44Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.82	-2.295	0.475	9.9	9.9	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.44	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G44L	44	G	L	missense	possibly_wt-like	0.762190555460989	0.194531780761897	7	0.073526101999217	0.618082043618906	0.906299067303073	NA	0.743925969869342	0.748739506288043	0.604663693646101	0.610251449303953	0.817070176528434	1.16480711936092	0.645875973230129	0.651160875580808	NA	0.651160875580808	0.661272914034901	0.560873475510127	0.608081205843719	0.694053314013168	0.914944690746276	0.618559495452244	p.Gly44Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.82	-3.356	1.536	9.877	9.877	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G44M	44	G	M	missense	possibly_low	0.6442463138883	0.203115706061179	4	0.10155785303059	0.445196579601133	0.843296048175468	0.728470884921161	NA	NA	NA	0.340190168228458	0.759688920608814	0.748635281794769	NA	0.659736858473061	0.653702056892689	NA	NA	NA	0.507203101586361	0.665771660053432	0.690797288727012	NA	p.Gly44Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.82	-4.976	3.156	1.311	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44N	44	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.82	-3.992	2.172	3.97	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G44P	44	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.82	-3.6	1.78	10.803	10.803	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G44Q	44	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.82	-2.819	0.999	8.069	8.069	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.56	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G44R	44	G	R	missense	wt-like	0.929917709414571	0.118927319171651	7	0.0449503015171134	0.841816737346813	1.01801868148233	NA	0.802912839988521	1.01861730224922	1.02712884651362	0.805034865443586	0.804902771196672	1.05664640227972	0.994180938230658	0.746146219406242	NA	0.67835282998274	0.793635143593545	0.746146219406242	0.680840179965023	0.688056332217183	0.856690043156293	0.793494987355239	p.Gly44Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.82	-2.912	1.092	16.562	16.562	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.5	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
G44S	44	G	S	missense	possibly_wt-like	0.788325553995913	0.134804422067391	7	0.0509512823460147	0.688462875631592	0.888188232360233	0.543434203458754	0.971257811558391	0.802855861051954	0.70098767935819	0.800956748792729	NA	0.857768595204271	0.841017978547099	0.687814413481444	0.565665948725175	0.755957028704823	0.687814413481444	0.603116507899323	0.679316849130479	NA	0.749575770273365	0.716569188455068	p.Gly44Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.82	-2.013	0.193	15.88	15.88	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.825	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
G44T	44	G	T	missense	possibly_wt-like	0.792800531101571	0.137867012887501	5	0.0616560025342584	0.671956986703714	0.913644075499428	0.859064095766289	0.996410771425567	NA	NA	0.669106681178404	0.673902230837435	NA	0.765518876300159	0.678649911048893	0.71583524013528	0.767552119890369	NA	NA	0.630065861302204	0.623489743501031	NA	0.678649911048893	p.Gly44Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.82	-2.805	0.985	7.139	7.139	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.025	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G44V	44	G	V	missense	possibly_low	0.658400809501968	0.159282434247528	8	0.0563148446901636	0.54802574211428	0.768775876889655	0.739698458181816	0.661266515748487	0.687811108959493	0.956952536519483	0.391554773570994	0.60758917332469	0.574221492795716	0.64811241691506	0.616369501650383	0.659043872613884	0.613056258353252	0.631390431539002	0.715370290502125	0.526389724682598	0.590805848463693	0.596859174343528	0.619682744947514	p.Gly44Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.82	-3.418	1.598	5.545	5.545	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.78	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G44W	44	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.82	-5.655	3.835	0.493	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G44X	44	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly44Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G44Y	44	G	Y	missense	possibly_wt-like	0.862501610506006	0.714043173562551	3	0.412253018469354	0.0545005417881468	1.67050267922386	1.31906517706242	NA	NA	NA	1.22879525220032	NA	0.0396444022552849	NA	0.839130714265768	0.934692953265996	NA	NA	NA	0.839130714265768	NA	0.308939485389064	NA	p.Gly44Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	92.1	11.7	0.273	137.9	3	52.4	-107.2	69.0721649484536	-0.5	0	0	97.3	0	0	0	0	4	14.00143127898	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.82	-4.532	2.712	2.462	NA	72.21	0.00372407	0	0.10644011	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45A	45	V	A	missense	possibly_wt-like	0.967862143758249	0.379195860660061	7	0.14332256364166	0.686955080848645	1.24876920666785	NA	1.10685768582625	1.16071292682481	1.11847086342067	0.430865203072172	1.41706560260889	0.442267370665068	1.09879535388989	0.818466288656224	NA	0.818466288656224	0.863326292553643	0.786204401697745	0.541073657121298	0.989774673643247	0.525789555999601	0.84603737435068	p.Val45Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.065	-2.577	0.512	20.988	20.988	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	2	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.8	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
V45C	45	V	C	missense	wt-like	1.02091633155395	0.0738171623410083	8	0.0260983080296376	0.969764587758432	1.07206807534948	0.912007415201991	1.12702434822939	1.03281967219832	1.01666840609066	0.991698952591014	1.07816827828734	1.07585361534143	0.9330899644915	0.781706447701339	0.741024428353269	0.827762780628037	0.80060073090607	0.741558777137052	0.750566277572843	0.822741437776669	0.867034921207125	0.762812164496609	p.Val45Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.065	-3.4	1.335	13.791	13.791	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V45D	45	V	D	missense	wt-like	1.11968260683722	0.105913975995797	8	0.0374462453245287	1.0462893146449	1.19307589902955	1.15251208706343	1.21215756967109	1.20899600789423	1.21641747152854	1.07250791638239	0.951337269009185	0.981204338911382	1.16232819423754	0.842304970770189	0.855450903900973	0.867007762958088	0.887006848553249	0.829159037639405	0.780751482359741	0.760229897060421	0.816057446280254	0.877946619968797	p.Val45Asp	0	0	NA	1.12222009243155	0.076734627078813	0.843315336442059	1.40112484842104	NA	NA	1.792	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.065	-4.32	2.255	2.254	NA	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45E	45	V	E	missense	possibly_low	0.472712794466682	0.45189265474358	3	0.260900345861021	-0.038642486974962	0.984068075908326	NA	0.930295970046228	0.461108221668838	0.0267341916849801	NA	NA	NA	NA	0.520203442248895	NA	0.737074309137443	0.520203442248895	0.307421601716338	NA	NA	NA	NA	p.Val45Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.065	-4.159	2.094	2.917	NA	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
V45F	45	V	F	missense	possibly_wt-like	0.846504053725814	0.363486818681124	6	0.148392872332717	0.555659368391239	1.13734873906039	NA	0.875491365843338	1.15909320988446	1.0490467089987	1.02578774948478	0.147727651153709	NA	0.821877636989896	0.733784320358128	NA	0.71181030893723	0.862531898391964	0.755758331779027	0.763299732710738	0.364152663011368	NA	0.706955989098304	p.Val45Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.065	-2.385	0.32	19.225	19.225	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.565	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V45G	45	V	G	missense	wt-like	1.00923566591622	0.0902440557459726	8	0.031906091889877	0.946700874924638	1.07177045690781	1.08158302266573	1.0170960614756	0.979339744695327	0.947516331470672	0.883508891134526	0.96241951078117	1.02345773549231	1.17896402961444	0.775729529627935	0.821704520555868	0.777087690479128	0.774371368776743	0.711232028234827	0.710153197046255	0.765692031373627	0.838814846505827	0.886301935962842	p.Val45Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.065	-3.493	1.428	11.133	11.133	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
V45H	45	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val45His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.065	-5.147	3.082	2.573	NA	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45I	45	V	I	missense	possibly_low	0.679121718925925	0.475495596149499	4	0.23774779807475	0.213144597295715	1.14509884055614	NA	0.682225822013614	0.977990413061465	1.04936572471865	NA	NA	NA	0.00690491590996742	0.689308191210139	NA	0.622718145805595	0.773709585754409	0.755898236614683	NA	NA	NA	0.297637523455923	p.Val45Ile	1	0	NA	NA	NA	NA	NA	NA	NA	-0.569	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.065	-2.441	0.376	19.607	19.607	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.38	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
V45K	45	V	K	missense	wt-like	1.0727166659802	0.146323608422314	7	0.0553051255461484	0.964320611749282	1.18111272021112	1.0532478237047	1.14834318248052	1.14978399435058	1.13111827281898	0.752350848880139	NA	1.10472954618501	1.16944299344145	0.83759040443123	0.808223298232996	0.83759040443123	0.857966170710967	0.791750942581646	0.661160706867589	NA	0.882587306772973	0.88152001404466	p.Val45Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.065	-4.123	2.058	3.267	NA	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45L	45	V	L	missense	possibly_wt-like	0.726906087979224	0.2378144161772	8	0.0840800931714091	0.56211213354649	0.891700042411958	0.405270614384096	0.529661830790556	0.651879996901304	0.563965505669869	1.0509715796494	1.05709091864484	0.746163452246645	0.810244805547076	0.651616953409841	0.499930957282088	0.552388713436453	0.613767929155636	0.543025222448837	0.772706845921596	0.812352982831923	0.689465977664046	0.701113422109139	p.Val45Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.065	-1.972	-0.093	14.163	14.163	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	neutral	0.475	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
V45M	45	V	M	missense	wt-like	0.947967785194889	0.151106500307464	6	0.0616889704284995	0.827059624911674	1.0688759454781	1.13077988685116	0.699434731940082	0.877388452314306	1.02147131125239	1.03690311816945	NA	NA	0.92182921064195	0.750410785676851	0.845111233336819	0.630651163663332	0.724369106390257	0.743665098597998	0.76745174338241	NA	NA	0.757156472755705	p.Val45Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.065	-2.924	0.859	7.797	7.797	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V45N	45	V	N	missense	wt-like	1.08069987759431	0.16710566741373	6	0.0682206030484781	0.946989952615689	1.21440980257293	1.21220776206937	1.02731112896108	1.22390106354963	1.0888658536618	1.15644504191409	NA	NA	0.775468415409892	0.796950919281206	0.883852704346272	0.781796664674851	0.894317069800676	0.773221079040556	0.812105173887561	NA	NA	0.68364704773446	p.Val45Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.065	-3.762	1.697	8.566	8.566	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45P	45	V	P	missense	wt-like	1.09023893910699	0.294981146554657	7	0.111492393605188	0.871717863090662	1.30876001512333	1.27123296926046	1.20247798907047	1.16421976292895	1.12557235751404	0.436285541960357	1.28924836107112	NA	1.14263559194357	0.865046228955924	0.911935511948611	0.862545639204278	0.865046228955924	0.78931877287726	0.543098358734558	0.926777045980255	NA	0.868056048730054	p.Val45Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.065	-4.472	2.407	2.106	NA	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45Q	45	V	Q	missense	wt-like	1.12269926599038	0.0846169527976256	8	0.0299166105632715	1.06406378674686	1.1813347452339	1.11380815442267	1.23343169735946	1.1799062972881	0.956548040522886	1.13824191989081	1.06007473052907	1.12460034476609	1.17498294314396	0.854888104960421	0.837036481562975	0.876814777788241	0.872739728357867	0.715192898159405	0.805305619231074	0.813823622221706	0.893289587600153	0.884302443018432	p.Val45Gln	0	0	NA	1.27827116018916	0.235716593201518	1.11291591634092	1.4436264040374	NA	NA	0.915	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.065	-3.432	1.367	5.945	5.945	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45R	45	V	R	missense	wt-like	1.02525475603592	0.166927548949766	8	0.0590178009146143	0.909581991796524	1.14092752027532	1.14206470871217	1.10354345423073	1.06658035764458	1.115275620586	0.637598347363296	1.13679252103115	1.02732989588603	0.972853142833428	0.817048612940522	0.850480286597798	0.816938483667744	0.8171587422133	0.78480312302807	0.618296306736966	0.85163572599606	0.840900366510089	0.78278314355762	p.Val45Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.065	-3.775	1.71	9.049	9.049	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V45S	45	V	S	missense	wt-like	1.09126357526517	0.141791909707641	8	0.0501310104358318	0.993008600302339	1.189518550228	1.05765646996976	0.848424405109235	1.01284706275962	1.0919064108597	1.3283591167922	1.13037372655592	1.21302861933621	1.04751279073871	0.815300817628827	0.810320828605867	0.69933289556382	0.79080511542761	0.774554520085825	0.876321583954925	0.848472077496601	0.940916472028125	0.820280806651786	p.Val45Ser	0	0	NA	NA	NA	NA	NA	NA	NA	0.859	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.065	-3.314	1.249	6.104	5.566	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.75	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
V45T	45	V	T	missense	wt-like	0.942123439331953	0.126548083302017	2	0.089483007849016	0.766739966719566	1.11750691194434	NA	NA	NA	NA	1.03160644718097	NA	NA	0.852640431482937	0.74393988963351	NA	NA	NA	NA	0.765473236407753	NA	NA	0.722406542859267	p.Val45Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.065	-2.571	0.506	6.895	6.895	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.605	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
V45V	45	V	V	synonymous	wt-like	0.892714572277831	0.197755379549983	8	0.0699170849479562	0.755679603875809	1.02974954067985	0.631863213617759	0.984690282107497	0.917758646188982	0.567285353327494	1.11733474804493	0.881733663252131	1.0816399821969	0.959410689486957	0.753158969473215	0.607738395344825	0.762149171565405	0.744168767381025	0.544481146755659	0.797495999678076	0.72592418065839	0.870151420164307	0.776031697483504	p.Val45=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V45W	45	V	W	missense	possibly_low	0.684323718464399	0.284335767966386	4	0.142167883983193	0.405679786099072	0.962967650829726	NA	0.391466186129273	0.585999185796678	NA	1.06779175178739	NA	NA	0.692037750144257	0.611600340671102	NA	0.488682847019354	0.581456523128759	NA	0.778989816482222	NA	NA	0.641744158213446	p.Val45Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.065	-3.615	1.55	16.757	16.757	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V45X	45	V	X	nonsense	low	0.210603632183464	0.236072355546364	8	0.083464181728758	0.0470168419959923	0.374190422370936	0.0416339223101263	0.0926113386335406	0.0418869192612634	0.308670190845977	0.531808952816515	0.0519737293446964	0.0233415542362541	0.592902450019339	0.338918474858312	0.326921157797521	0.350915791919103	0.314595322219904	0.431065068670005	0.57877996611267	0.316958169992888	0.300158879160754	0.591953646349001	p.Val45Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V45Y	45	V	Y	missense	wt-like	1.08440257390692	0.119906800695753	4	0.0599534003478766	0.966896068474368	1.20190907933947	1.07895398166227	1.2172000293763	1.11389252588712	0.927563758701983	NA	NA	NA	NA	0.830408398102775	0.820453684579299	0.869332252019819	0.840363111626251	0.702481796696083	NA	NA	NA	NA	p.Val45Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	92.3	15.5	0.699	114.2	100.5	-81.1	-20.8	53.3333333333333	-0.8	0	0	90.96	0	0	0	0	3	10.5978402450688	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.065	-3.178	1.113	17.327	17.327	43.18	0.00344514	0	0.098467827	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.6	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y46A	46	Y	A	missense	possibly_wt-like	0.891018120477903	0.297958443407894	7	0.112617706041314	0.670291472615408	1.1117447683404	1.10599314014216	0.824656646207609	NA	0.314191217282555	1.18847937434309	1.00243088789178	1.05600201237777	0.745373565100352	0.785412546440081	0.833318281273755	0.688376358711071	NA	0.433486323322808	0.824071208832366	0.785412546440081	0.856342979012657	0.668531967641822	p.Tyr46Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.1	-3.566	2.466	5.683	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46C	46	Y	C	missense	possibly_wt-like	0.747525180926861	0.413711202517471	5	0.185017274376449	0.384897986631255	1.11015237522247	NA	0.835369180343589	0.90534553448954	0.861445050535997	0.0318338902795306	NA	NA	1.10363224898565	0.693314656660532	NA	0.693314656660532	0.738080726182797	0.673485335327303	0.392020367388166	NA	NA	0.848466695514275	p.Tyr46Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.1	-3.656	2.556	18.229	18.229	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y46D	46	Y	D	missense	possibly_wt-like	0.957245369793541	0.349419404356965	6	0.142649874483632	0.677656753406462	1.23683398618062	1.00177292464932	0.406615804294044	1.0808489166781	1.0946587807631	NA	1.42699126259995	NA	0.732584529776734	0.779747163050352	0.783732749951774	0.495666566031921	0.824156792125258	0.77576157614893	NA	0.994666760382905	NA	0.66210869950007	p.Tyr46Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.1	-4.191	3.091	2.465	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	not specified	Uncertain significance(Last reviewed: Mar 5, 2015)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y46E	46	Y	E	missense	wt-like	1.04914205843775	0.157713766322344	7	0.059610200574325	0.932308212200864	1.16597590467464	0.91241647268204	0.929278241632665	0.942043133924239	1.09302043038575	1.34453069116182	NA	1.14862366598661	0.974081773291132	0.775043075065905	0.74121904829714	0.736605153466711	0.756079154187321	0.775043075065905	0.882362278714155	NA	0.906228389684758	0.78340022081773	p.Tyr46Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.1	-4.034	2.934	3.053	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46F	46	Y	F	missense	wt-like	0.869878548185599	0.0687498847673819	2	0.0486135097248095	0.774597819962885	0.965159276408313	NA	NA	NA	NA	NA	0.82126503846079	NA	0.918492057910409	0.725800620589184	NA	NA	NA	NA	NA	0.696120846897878	NA	0.75548039428049	p.Tyr46Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.1	-1.848	0.748	17.599	17.599	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y46G	46	Y	G	missense	wt-like	1.11654016563585	0.173802933808267	8	0.061448616542971	0.996103090311815	1.23697724095989	0.839447845157995	1.09906092962663	1.16004798958879	1.25950273578974	1.36661109894307	1.15291917785017	1.15439385205252	0.900337696077882	0.85381913070367	0.706502288707789	0.814872115264166	0.863000172448939	0.848054146684449	0.890610146269741	0.85958411472289	0.909336173775592	0.746362401324653	p.Tyr46Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.1	-2.901	1.801	36.943	36.943	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46H	46	Y	H	missense	wt-like	1.10031215431775	0.105856676403144	5	0.0473405448619257	1.00752639137987	1.19309791725563	NA	1.01497003271376	0.975036826276869	1.1619084048806	1.23376171062564	NA	1.11588379709188	NA	0.805254002451222	NA	0.776107627000046	0.772260991843184	0.805254002451222	0.840985874356932	NA	0.888594912614032	NA	p.Tyr46His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.1	-3.425	2.325	20.732	20.732	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	2	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.685	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y46I	46	Y	I	missense	wt-like	1.03253622354271	0.16339858433035	4	0.0816992921651748	0.872408553336556	1.19266389374887	1.05044090863325	NA	NA	NA	1.25120583860928	0.869658637076286	0.958839509852034	NA	0.805449865533691	0.806887833951566	NA	NA	NA	0.847501916028675	0.71997273002548	0.804011897115815	NA	p.Tyr46Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.1	-3.212	2.112	7.142	7.142	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46K	46	Y	K	missense	possibly_low	0.706602734839325	0.119058996798786	4	0.0595294983993929	0.58992706195878	0.82327840771987	NA	0.723668608348483	0.747812909186711	0.816815998617586	NA	NA	NA	0.538113423204519	0.647867884334024	NA	0.641822572842153	0.660818462204961	0.653913195825896	NA	NA	NA	0.564435964088221	p.Tyr46Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.1	-4.057	2.957	2.653	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46L	46	Y	L	missense	possibly_wt-like	0.861421347892381	0.370698193371677	3	0.214022701731246	0.441944560625182	1.28089813515958	1.11485703665215	NA	NA	NA	0.435964630387201	NA	NA	1.03344237663779	0.813213968508897	0.83753551509881	NA	NA	NA	0.542978486122663	NA	NA	0.813213968508897	p.Tyr46Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.1	-3.403	2.303	5.214	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46M	46	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr46Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.1	-4.737	3.637	1.146	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46N	46	Y	N	missense	possibly_wt-like	0.928035863997111	0.365995562458656	3	0.211307636507713	0.513880506783712	1.34219122121051	1.10165069684135	NA	NA	NA	NA	1.17491418161494	NA	0.507542713535045	0.831252248716752	0.831252248716752	NA	NA	NA	NA	0.870424851394628	NA	0.549081884556667	p.Tyr46Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.1	-4.227	3.127	3.195	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y46P	46	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr46Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.1	-4.451	3.351	1.333	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46Q	46	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr46Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.1	-4.34	3.24	2.343	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46R	46	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr46Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.1	-4.296	3.196	2.772	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46S	46	Y	S	missense	wt-like	0.971403925009563	0.286979026737204	6	0.117158697064447	0.741777098287609	1.20103075173152	0.924277291615869	1.11062826125368	1.09743444619264	1.17842888403535	0.411653145862597	NA	NA	1.10600152109724	0.816351772258579	0.746862147440301	0.820204460471149	0.83229120591479	0.812499084046009	0.533897227007112	NA	NA	0.849656657828743	p.Tyr46Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.1	-3.885	2.785	3.747	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y46T	46	Y	T	missense	wt-like	1.06099766014445	0.338500026646021	6	0.13819205720021	0.790146205082544	1.33184911520637	0.678380271821507	1.06901042683412	NA	NA	1.65945922740996	1.10166649773353	1.05454002096894	0.802929516098669	0.817671203809233	0.629870119364593	0.801019339213531	NA	NA	1	0.834323068404935	0.855555560099405	0.697439332197535	p.Tyr46Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.1	-3.936	2.836	2.136	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46V	46	Y	V	missense	possibly_wt-like	0.932644242260109	0.65438371137676	5	0.292649292401408	0.359062169052218	1.506226315468	NA	1.31989064165601	1.26673887329513	1.18686139268197	-0.229971839167209	NA	NA	1.11970214283464	0.856537768475572	NA	0.916670896043051	0.915326979071387	0.816197173709222	0.294226023952023	NA	NA	0.856537768475572	p.Tyr46Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.1	-3.617	2.517	4.637	NA	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46W	46	Y	W	missense	possibly_low	0.448620007200031	0.398113012927483	5	0.178041551926621	0.0996649776722364	0.797575036727825	NA	0.76830240325368	0.899188289436909	NA	0.0399103843278378	0.0483412225397109	NA	0.487357736442016	0.538944019031798	NA	0.662398001126365	0.735060890185535	NA	0.395037243429761	0.315167806592532	NA	0.538944019031798	p.Tyr46Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.1	-2.983	1.883	37.21	37.21	74.94	0.002214488	0	0.063293745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y46X	46	Y	X	nonsense	low	0.00576031897673071	0.0540799937045389	5	0.0241853084292219	-0.0416420144995372	0.0531626524529986	-0.0485115055373168	NA	NA	NA	0.0448935766146482	0.0753265110490426	-0.000227309140831915	-0.0426796781018885	0.287464845067971	0.284032079945156	NA	NA	NA	0.396898654251192	0.328468118330107	0.287464845067971	0.272733757458039	p.Tyr46Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	95.3	15.6	0.445	33.7	147.1	-69.8	134.9	10.5882352941176	-3.5	0	0	84.3	0	0	0	0	6	12.1110973020614	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R47A	47	R	A	missense	wt-like	1.05174526580501	0.18440737161466	8	0.0651978514847567	0.923959825025497	1.17953070658453	1.02208124117398	1.14194558805316	1.15355555818887	1.17906093750645	1.04367274227507	0.620892144241184	1.07340278574887	1.1793511292525	0.823708746569397	0.793394970091777	0.834641221068909	0.859815943482309	0.812776272069885	0.769980454064632	0.597362519524078	0.865714920581478	0.886496356003913	p.Arg47Ala	0	0	NA	NA	NA	NA	NA	NA	NA	0.139	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.952	-3.327	2.375	4.312	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47C	47	R	C	missense	wt-like	1.01486690836649	0.144367571973122	8	0.0510416445628156	0.914827123311681	1.11490669342131	1.14927571460597	0.88498591374657	1.139964120217	0.930258890037588	1.060788200674	1.08294534055477	1.12078338486761	0.749933702228443	0.800734823260167	0.853911113879427	0.716187135731565	0.853149989262336	0.703663750697066	0.776373725213697	0.825095921306637	0.891233798217915	0.670822287653903	p.Arg47Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.952	-5.278	4.326	0.646	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47D	47	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.952	-3.916	2.964	6.558	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47E	47	R	E	missense	wt-like	1.17390302622342	0.130248665352504	8	0.0460498572556264	1.08364696450918	1.26415908793766	1.12738909839104	0.889220831972848	1.1944771297196	1.24355970768068	1.33509130909898	1.17222058057023	1.2366309732443	1.19263457910968	0.873966780723151	0.843497975807071	0.718139361762074	0.879886029002165	0.84106230713572	0.878836312444324	0.869097249001978	0.953628543899629	0.893167942884483	p.Arg47Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.952	-2.964	2.012	21.524	21.524	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47F	47	R	F	missense	wt-like	0.99979299758188	0.150336140673405	6	0.0613744724248526	0.879501242059022	1.12008475310474	NA	1.09049593884612	0.999282748976554	1.14688698006228	0.722610099276037	0.96723092468348	NA	1.07225129364681	0.791409398889427	NA	0.81092379865937	0.784152464332823	0.79866633344603	0.650051411868667	0.768063445886283	NA	0.832705671669615	p.Arg47Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.952	-3.355	2.403	8.895	8.895	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47G	47	R	G	missense	wt-like	1.02568969957949	0.163959347239351	8	0.0579683831359325	0.912073756391041	1.13930564276793	0.904506870345117	1.17435576469119	1.20913037744314	1.19634673272736	0.793205593851791	0.886376462048022	0.933870935498529	1.10772486003075	0.805460486072087	0.737455845231715	0.849581767050065	0.887072750429375	0.820356984204993	0.676421499552291	0.728212489389973	0.79056398793918	0.850522201459594	p.Arg47Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-0.029	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.952	-2.965	2.013	9.615	9.615	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R47H	47	R	H	missense	wt-like	0.890943998039433	0.138170081458966	4	0.0690850407294828	0.755539806339165	1.0263481897397	NA	0.819167294411388	1.05372909806834	NA	0.741803980383867	NA	NA	0.949075619294144	0.728343394238471	NA	0.685845859916382	0.810855810310027	NA	0.657221052521293	NA	NA	0.77084092856056	p.Arg47His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.952	-4.596	3.644	1.823	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47I	47	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.952	-3.988	3.036	4.341	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47K	47	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.952	-2.596	1.644	20.763	20.763	74.94	0.000637358	0	0.01821675	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Nov 15, 2016)	criteria provided, single submitter	0	1	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.8	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R47L	47	R	L	missense	wt-like	0.943560969100164	0.0778247265850767	8	0.0275151959561484	0.889632175998551	0.997489762201777	0.839463863747521	0.929750547680747	0.864213904849028	0.972460581991677	1.00568046946588	1.06487775310193	0.988691085190877	0.883349546773652	0.737326507475668	0.70650990997655	0.736822878606174	0.717907617145765	0.722171367745057	0.755788903013121	0.816190900877241	0.82008975836062	0.737830136345161	p.Arg47Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.952	-2.59	1.638	14.163	14.163	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R47M	47	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.952	-4.654	3.702	1.88	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R47N	47	R	N	missense	wt-like	1.17151236951564	0.0316148858863596	3	0.018252862876889	1.13573741566219	1.20728732336909	NA	NA	NA	NA	1.18375546282682	NA	1.19517472806466	1.13560691765542	0.864525910725788	NA	NA	NA	NA	0.822306649186707	NA	0.931300484151923	0.864525910725788	p.Arg47Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.952	-3.796	2.844	3.144	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47P	47	R	P	missense	possibly_wt-like	0.765464266924999	0.142028064572616	3	0.0819999413134813	0.604747335216178	0.926181198633821	NA	0.625569967934655	0.909534017283493	0.76128881555685	NA	NA	NA	NA	0.629561664115752	NA	0.596600750568232	0.740134977882537	0.629561664115752	NA	NA	NA	NA	p.Arg47Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.952	-4.147	3.195	2.032	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47Q	47	R	Q	missense	wt-like	1.10759112844799	0.153971179912582	8	0.0544370327117402	1.00089650490775	1.21428575198823	0.928408348963753	1.23852783766085	1.2753655306518	1.21091196536311	0.893231964703161	1.18431430309253	0.959134185630703	1.17083489151801	0.850901251989448	0.748827607524487	0.879164012701391	0.919557944413684	0.826744589425433	0.713785132824877	0.875057914553462	0.80417060754325	0.882219092149109	p.Arg47Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.952	-3.814	2.862	4.721	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47R	47	R	R	synonymous	wt-like	1.01170485773867	0.193329908023041	8	0.068352444484632	0.877736528293516	1.14567318718382	1.01663293363422	0.806916880604846	0.90078985613221	0.699565140211026	1.21159633357965	1.07289987645326	1.21234456712289	1.17289327417123	0.805473789844814	0.790802793296836	0.680198625320628	0.735846382514839	0.602492651163907	0.832706267566784	0.820144786392792	0.94054804602564	0.883252910837181	p.Arg47=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R47S	47	R	S	missense	wt-like	1.14853450793609	0.107025311371157	8	0.0378391617145733	1.07437111377034	1.22269790210184	1.09703543548395	1.25738426057109	1.07084744695279	1.23806382100725	0.968832625210922	1.08449568583968	1.23693102986219	1.23468575856084	0.833854246649645	0.829056415734501	0.887856506317729	0.819251546671514	0.838652077564788	0.742024839317624	0.825860044157613	0.953790152411515	0.914288066056937	p.Arg47Ser	1	0	NA	NA	NA	NA	NA	NA	NA	1.294	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.952	-3.644	2.692	3.997	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R47T	47	R	T	missense	wt-like	1.08762436221587	0.37691671354055	7	0.142461127001724	0.808405684095508	1.36684304033624	1.21877115215403	1.2753920200279	1.21924905320508	1.32521562977156	0.251670705694385	NA	1.25215065955119	1.07092131510698	0.886975411232666	0.886975411232666	0.896157780364667	0.892035479872385	0.876872637617316	0.474137733849246	NA	0.961987344404219	0.83203769253218	p.Arg47Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.952	-3.69	2.738	3.024	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R47V	47	R	V	missense	possibly_wt-like	0.851923074843055	0.204260760836455	7	0.0772033108260147	0.700607366136815	1.0032387835493	1.02021232854699	0.680064265343902	0.691555807878649	0.546886281113188	0.995875453445369	NA	1.00518081576192	1.02368657181136	0.752126358629034	0.792505785348058	0.621721704558903	0.633227028344604	0.535535102196891	0.752126358629034	NA	0.828971018296691	0.808314134490688	p.Arg47Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.952	-3.114	2.162	6.213	6.213	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R47W	47	R	W	missense	wt-like	0.820369113659943	0.0309665717108265	2	0.0218966728468249	0.77745242349891	0.863285803820977	0.798472440813119	NA	NA	NA	NA	NA	NA	0.842265786506768	0.702101525523999	0.687007153469719	NA	NA	NA	NA	NA	NA	0.717195897578278	p.Arg47Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.952	-5.495	4.543	0.413	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R47X	47	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R47Y	47	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg47Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	98.6	15.9	0.614	39.3	88.6	-134.5	-45	72.8301886792453	-1.1	0	0	75.95	0	0	0	0	4	14.1866626752031	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.952	-4.319	3.367	2.063	NA	74.94	0.000637358	0	0.01821675	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48A	48	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-0.843	-2.858	2.015	20.988	20.988	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.34	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N48C	48	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-0.843	-5.234	4.391	1.553	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48D	48	N	D	missense	possibly_wt-like	0.832635458025316	0.329124062162981	6	0.134364335728559	0.569286199190692	1.09598471685994	NA	0.701309300993034	1.02427413120182	NA	0.227724836488367	1.07032110278949	0.890875235255386	1.0813081414238	0.781908168573989	NA	0.631515308448572	0.796409549282355	NA	0.465193045885545	0.818873779280272	0.767406787865623	0.837254455867843	p.Asn48Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-0.843	-3.344	2.501	3.671	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N48E	48	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-0.843	-3.452	2.609	3.868	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N48F	48	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-0.843	-4.46	3.617	1.597	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48G	48	N	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-0.843	-3.19	2.347	5.678	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N48H	48	N	H	missense	wt-like	1.1520669005565	0.122018036828056	4	0.0610090184140281	1.03249142173286	1.27164237938013	NA	1.2695469820614	1.16490568296458	1.19228131949341	NA	NA	NA	0.981533617706595	0.841978365545984	NA	0.893463316231522	0.865382640126364	0.818574090965604	NA	NA	NA	0.787142895196207	p.Asn48His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-0.843	-3.003	2.16	8.609	8.609	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.06	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N48I	48	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-0.843	-4.201	3.358	3.112	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	2	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N48K	48	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-0.843	-2.9	2.057	7.563	7.563	74.94	0.000625471	0	0.017877	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Dec 15, 2015)	criteria provided, single submitter	0	1	0	0	0	4	0	0	0	0	2	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.335	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N48L	48	N	L	missense	low	0.533961125870725	0.0914291539994882	5	0.0408883606936305	0.453821411524326	0.614100840217124	0.612512575714633	0.469262104644361	0.6113059663634	0.568799335754596	NA	NA	NA	0.407925646876637	0.545145106082424	0.598531816205564	0.524545456183811	0.593868295971474	0.545145106082424	NA	NA	NA	0.499049406386867	p.Asn48Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-0.843	-3.763	2.92	4.314	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N48M	48	N	M	missense	wt-like	0.872943920158581	0.0766919078755354	4	0.0383459539377677	0.797787231487724	0.948100608829437	NA	0.831169216586459	0.805570107206678	0.979498416688874	0.875537940152312	NA	NA	NA	0.699277144692161	NA	0.691378544052033	0.689145622191411	0.725257820998269	0.707175745332289	NA	NA	NA	p.Asn48Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-0.843	-4.898	4.055	1.309	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48P	48	N	P	missense	possibly_wt-like	0.829649605481482	0.434179230271837	4	0.217089615135919	0.40416177839742	1.25513743256554	0.696501572627985	1.42997567824234	0.793908202677048	NA	NA	0.398212968378559	NA	NA	0.660958910589424	0.638491808779507	0.967418245226731	0.683426012399341	NA	NA	0.487610035113354	NA	NA	p.Asn48Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-0.843	-4.073	3.23	2.182	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48Q	48	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-0.843	-3.911	3.068	2.479	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N48R	48	N	R	missense	possibly_wt-like	0.877405000199405	0.306752035424094	3	0.177103370226566	0.530288773014672	1.22452122738414	0.813431927765291	NA	NA	NA	0.607684069257744	1.21109900357518	NA	NA	0.694124526095749	0.694124526095749	NA	NA	NA	0.607122192278582	0.888259361930748	NA	NA	p.Asn48Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-0.843	-3.724	2.881	2.967	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48S	48	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-0.843	-2.437	1.594	16.481	16.481	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	2	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.34	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N48T	48	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-0.843	-3.447	2.604	6.155	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N48V	48	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-0.843	-3.916	3.073	4.948	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48W	48	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-0.843	-5.704	4.861	0.393	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N48X	48	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N48Y	48	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn48Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.5	101.2	17.9	0.486	67.5	-135.9	-69.8	126.4	3.74331550802139	-2.5	0	0	68.17	1	24	0	0	5	15.293261191126	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-0.843	-4.305	3.462	1.411	NA	74.94	0.000625471	0	0.017877	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N49A	49	N	A	missense	wt-like	1.09017589497961	0.114242038669229	7	0.043179431941115	1.00554576350212	1.17480602645709	1.06760712199627	1.0638263160778	1.08744538387308	1.28706730449349	1.06375146766351	1.15440543100398	NA	0.907128239749127	0.815055115187423	0.815055115187423	0.798629551401162	0.827392045703748	0.860142630772172	0.77748061752762	0.860316648312804	NA	0.749772938689276	p.Asn49Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.199	-3.085	0.886	20.988	20.988	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.535	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N49C	49	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn49Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.199	-4.14	1.941	17.629	17.629	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.085	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N49D	49	N	D	missense	wt-like	1.07712534956556	0.174133750555585	8	0.0615655779256505	0.956459034143889	1.19779166498723	0.734852311573103	1.08341887581563	1.19080175360004	1.24216344810371	1.19888448158537	1.20919641238304	0.93809589309099	1.01958962037258	0.817809650846984	0.656738189850508	0.807661391706165	0.878083431734318	0.840449975346317	0.827957909987804	0.887321626691938	0.792839522183712	0.806256448591076	p.Asn49Asp	1	0	NA	NA	NA	NA	NA	NA	NA	2.519	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.199	-2.508	0.309	19.098	19.098	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
N49E	49	N	E	missense	wt-like	0.845769191727302	0.103081820569187	8	0.0364449271707636	0.77433844705342	0.917199936401183	0.982024471128393	0.790612617597974	0.805877124872846	0.708813068085682	0.978855835394542	0.823462902485459	0.754282518863374	0.922224995390143	0.695521483676085	0.77433689948273	0.672682634468016	0.689296199761764	0.606548344186305	0.745768887475397	0.697204114051934	0.693838853300236	0.757355254876461	p.Asn49Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.199	-3.326	1.127	6.192	6.192	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N49F	49	N	F	missense	wt-like	0.901826931580928	0.102036621961879	7	0.0385662180474633	0.826238533187981	0.977415329973874	0.809623822756105	0.867158149371063	0.800441006505443	0.812179813316866	1.01731603153557	1.02072618501479	NA	0.985343512566657	0.707968836387869	0.692312719151027	0.707968836387869	0.686630042122928	0.651879989616946	0.760135225591775	0.794429798747145	NA	0.789056407486917	p.Asn49Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.199	-3.856	1.657	10.712	10.712	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N49G	49	N	G	missense	wt-like	0.896797170109254	0.124134771237655	8	0.0438882692615932	0.810777743012735	0.982816597205773	1.13394706031403	0.911447751214428	0.719822182501806	0.968706659812015	0.860776035074752	0.813701465313252	0.826701070459263	0.939275136184481	0.724455338425395	0.846618100101609	0.728385597463194	0.647090341379809	0.720525079387596	0.701661615378077	0.692392968254764	0.732843006712313	0.765918654961408	p.Asn49Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.199	-3.127	0.928	21.128	21.128	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.88	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N49H	49	N	H	missense	wt-like	1.08923198860842	0.212881492755709	6	0.0869085054889135	0.918894447899951	1.2595695293169	NA	0.953509226964552	0.80859728706934	NA	1.29517251122725	1.37483843337122	1.01553408473568	1.0877403882825	0.837516129957651	NA	0.747775229907914	0.690630310008984	NA	0.863925131406094	0.968962055150686	0.834547220560752	0.84048503935455	p.Asn49His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.199	-2.417	0.218	18.009	18.009	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	-0.24	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
N49I	49	N	I	missense	possibly_wt-like	0.735215972826595	0.130485258001728	7	0.0493187917760963	0.638552917184417	0.831879028468774	0.888267710085605	0.53555237270047	0.775623034672781	NA	0.777929831766491	0.580951057093757	0.745720674644779	0.842467128822286	0.674458006727443	0.729729634094242	0.555104154121701	0.674458006727443	NA	0.6707154245677	0.57767664846086	0.689227500573162	0.717297021365032	p.Asn49Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.199	-4.424	2.225	3.112	NA	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N49K	49	N	K	missense	wt-like	0.975554820733247	0.0896632743269588	7	0.0338895322292708	0.909132558110967	1.04197708335553	NA	1.10004141957994	0.957508228553003	0.91478361577026	0.939865395890951	1.01223560930529	1.06405828313802	0.840391192895266	0.763664047928238	NA	0.815324104631429	0.763664047928238	0.696877045316535	0.731204483405256	0.790245025857692	0.860682033215449	0.7162543865793	p.Asn49Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.199	-2.713	0.514	14.163	14.163	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.28	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N49L	49	N	L	missense	possibly_wt-like	0.894637070975026	0.255337844056737	7	0.0965086336682169	0.705483624788151	1.0837905171619	0.89615946356463	1.09985608839738	1.10488167322851	1.06278274015242	0.647272984791902	NA	0.444364662454959	1.00714188423537	0.761782289411554	0.73348434509219	0.815238670075314	0.835943716752101	0.761782289411554	0.621910149785064	NA	0.526919143500594	0.800004597302544	p.Asn49Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.199	-3.978	1.779	4.943	NA	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N49M	49	N	M	missense	wt-like	0.939553956749184	0.138774039554697	7	0.0524516567276526	0.836750598633526	1.04235731486484	1.22824717120326	0.891179003241861	1.00702576912395	0.889235267841679	0.834357008044415	0.855640804650787	NA	0.87119267313834	0.71904204576193	0.891483878588556	0.71904204576193	0.787950047630019	0.685672777957175	0.691793109413316	0.713063723250186	NA	0.731724370183049	p.Asn49Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.199	-5.125	2.926	1.309	NA	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N49P	49	N	P	missense	possibly_wt-like	0.709725448259672	0.282604140567286	8	0.0999156520932623	0.513894368665044	0.9055565278543	0.847456302808551	0.953006298101305	1.04778552013356	0.627421494115422	0.700152371108329	0.255033463924347	0.360674959340176	0.886273176545681	0.675987562842907	0.710312524810204	0.747543388166028	0.80794076787684	0.570853943980419	0.641662600875609	0.4170407676025	0.481844422350199	0.73929852371745	p.Asn49Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.199	-1.808	-0.391	17.923	17.923	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.665	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N49Q	49	N	Q	missense	possibly_wt-like	0.977201550539964	0.426011663290837	6	0.173918533256151	0.636327489113877	1.31807561196605	NA	1.04173761829954	NA	1.58087892969335	0.340158050241928	0.974516599597439	0.705470143784376	1.22044796162316	0.78005069477395	NA	0.788447033468429	NA	0.988994171827972	0.507191104303445	0.771654356079471	0.667548830591507	0.907137160209516	p.Asn49Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.199	-3.448	1.249	7.857	7.857	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N49R	49	N	R	missense	wt-like	1.10641933123315	0.1936490328042	8	0.0684652721330331	0.972229863660673	1.24060879880563	0.701725337713608	1.14971691751175	1.12100173229809	1.32337173902345	1.28480707684643	1.15797978865109	1.12735982825213	0.98539222956867	0.851951544490448	0.640977153547285	0.838223673161272	0.843849839415758	0.876063996487917	0.860053249565139	0.862078351581298	0.894775827173522	0.789080875506519	p.Asn49Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.199	-2.959	0.76	13.83	13.83	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.28	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N49S	49	N	S	missense	wt-like	0.95310683485547	0.228692652694684	8	0.0808550627639754	0.794633823870353	1.11157984584059	1.06645608814464	0.774224417026905	0.903786002204693	0.476559047276469	1.12903252363236	1.10000347962736	1.04784240935152	1.12695071157981	0.808186520833701	0.814507480308406	0.665127949810942	0.737315849733603	0.504692985409004	0.801865561358996	0.833503412197459	0.851948270734131	0.860178348043615	p.Asn49Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.199	-2.395	0.196	12.006	12.006	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.24	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
N49T	49	N	T	missense	possibly_wt-like	0.777485354517357	0.287527932611389	8	0.101656475465031	0.578242323810617	0.976728385224097	1.21165794952559	0.406571477160513	0.601776372371903	0.451836485758179	0.733932923107137	0.864307074261915	0.855899695257284	1.09390085869634	0.685808002875305	0.883591116448163	0.495646131969369	0.589194483133294	0.493850867952584	0.654280914885066	0.717335090865545	0.748569193109948	0.843579123649895	p.Asn49Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.199	-3.247	1.048	6.956	6.956	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.625	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
N49V	49	N	V	missense	possibly_wt-like	0.745137155539099	0.196390131316233	7	0.0742284924871529	0.599651983637577	0.89062232744062	0.921517763074425	0.8677715222349	0.653483853054985	0.817390921049578	0.640326467193012	NA	0.927346196329276	0.388123365837514	0.65416532894452	0.74554922855716	0.708251590955303	0.61455454435544	0.65416532894452	0.619315362691647	NA	0.787049806532302	0.48910374921148	p.Asn49Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.199	-4.075	1.876	4.948	NA	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N49W	49	N	W	missense	wt-like	0.922943826151906	0.224404553639728	7	0.0848169488573106	0.756705661113002	1.08918199119081	NA	1.0239736164376	1.08181929494305	1.24778219902095	0.957371333390052	0.783417959184122	0.796022709477866	0.570219670609704	0.737743613269131	NA	0.780258127570392	0.824632716534702	0.842914087220724	0.737743613269131	0.677467055126767	0.716319844183094	0.580561264463932	p.Asn49Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.199	-5.793	3.594	1.985	NA	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N49X	49	N	X	nonsense	low	-0.0749406490709206	0.105062530874954	7	0.0397099041151676	-0.152770630966188	0.00288933282434688	NA	-0.0265141368325377	-0.0108676258154429	-0.0581591950849277	-0.308565374142788	-0.0445783988502963	-0.0630268607089158	-0.0128729520615359	0.270191476110151	NA	0.296000952558456	0.288721725687682	0.270191476110151	0.264868365632227	0.269370262845789	0.25364142151706	0.287704127696313	p.Asn49Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N49Y	49	N	Y	missense	wt-like	1.00547927597552	0.329563655561615	7	0.12456335339734	0.761339589523198	1.24961896242784	1.26923494003236	0.665832254555446	0.863656850185364	0.530271312038243	NA	1.43699611058312	1.15096037880416	1.12140308562995	0.857392063689526	0.910984896557889	0.61516098710389	0.717634408314316	0.528248581901975	NA	0.999597876721247	0.907486927769365	0.857392063689526	p.Asn49Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39	103.3	16	0.712	12	-137.6	-82.5	126	35.8288770053476	-2.8	0	0	69.63	0	0	0	0	7	18.4026356226493	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.199	-3.775	1.576	22.919	22.919	72.21	0.003401098	0	0.097209037	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I50A	50	I	A	missense	wt-like	0.817404964359049	0.0565405490774766	8	0.0199901028323473	0.778225082760396	0.856584845957701	0.823729778769389	0.880530110473099	0.90874377345087	0.729014661803928	0.792594752223844	0.792773715085163	0.824790020678863	0.787062902387234	0.694247179044279	0.699024001798214	0.7141330854117	0.739747400848983	0.61540778424627	0.676193327097567	0.682078251704542	0.731813727927109	0.689470356290343	p.Ile50Ala	0	0	NA	NA	NA	NA	NA	NA	NA	4.128	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.734	-3.013	1.279	8.187	7.331	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50C	50	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.734	-5.18	3.446	1.366	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50D	50	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.734	-4.291	2.557	3.671	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50E	50	I	E	missense	possibly_wt-like	0.762874307861704	0.255378743784648	7	0.096524092312323	0.573690563289131	0.952058052434276	0.488145898674697	0.859074572256205	0.684729693135579	0.984420183083556	1.12851274003977	0.42002339517486	NA	0.775213672667255	0.683519103686944	0.539361071541369	0.704242443380957	0.629879143560686	0.727416269236116	0.801671402524989	0.498359798838135	NA	0.683519103686944	p.Ile50Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.734	-4.08	2.346	3.868	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50F	50	I	F	missense	wt-like	1.00501009196521	0.278193804416322	6	0.113572145070602	0.782412777979874	1.22760740595055	1.12354078454054	0.893927418415345	1.00708579982932	1.10238859635866	NA	1.36711231431119	NA	0.536005638336223	0.783565494264445	0.841667038439802	0.72030901890229	0.787979489837287	0.779151498691603	NA	0.965154062066437	NA	0.563377333233618	p.Ile50Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.734	-2.892	1.158	13.582	13.582	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.745	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I50G	50	I	G	missense	low	0.523674601017301	0.0794689524576105	8	0.0280965175882839	0.468606438453269	0.578742763581334	0.544002145431345	0.395376849310754	0.568420228585013	0.658023425350555	0.473813178106633	0.510185072954609	0.567660493211978	0.471915415187523	0.56152625629809	0.565936162179809	0.49048559693128	0.57283488027902	0.584274468087484	0.557116350416371	0.542798027498867	0.593325463316985	0.53118814318669	p.Ile50Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.734	-3.438	1.704	11.513	11.513	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50H	50	I	H	missense	low	0.466882148183566	0.015837947991838	3	0.00914404353649897	0.448960152178962	0.48480414418817	NA	NA	NA	NA	0.456482669022548	0.459053890163645	0.485109885364506	NA	0.548864251351433	NA	NA	NA	NA	0.550642749701544	0.517596863894646	0.548864251351433	NA	p.Ile50His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.734	-5.062	3.328	1.754	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50K	50	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.734	-3.445	1.711	7.494	7.494	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.745	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50L	50	I	L	missense	wt-like	0.998626170714493	0.13321307615732	8	0.0470979347467804	0.906315914864586	1.0909364265644	1.10665896869028	0.841032327807869	0.79280849918364	1.20006658213688	1.04330522406078	0.97449036652653	1.04393871093654	0.986708686373425	0.780691744947016	0.833635066862537	0.695925272333291	0.682886660113161	0.821988329896596	0.769843172109254	0.771641426515246	0.849845764559994	0.789742063378786	p.Ile50Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.734	-2.099	0.365	18.729	18.729	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.7	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I50M	50	I	M	missense	possibly_wt-like	0.709446930407008	0.462618146084644	7	0.174853223789388	0.366740909199086	1.05215295161493	1.21398336672858	1.07867321703654	0.892170147291284	0.762683282638293	-0.135002894071935	0.343673293000528	NA	0.809948100225778	0.700964402438025	0.884697495349898	0.805473722876346	0.731618825089198	0.63017320980348	0.329700517394325	0.460728918598956	NA	0.700964402438025	p.Ile50Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.734	-2.072	0.338	8.28	8.28	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
I50N	50	I	N	missense	low	0.471793720467114	0.112648133837126	4	0.0563240669185629	0.361400577843907	0.582186863090321	0.46546824183149	0.355465942186935	0.625247249924023	NA	NA	NA	NA	0.440993447926006	0.522114610062327	0.528571574912616	0.472087340430165	0.600705832821889	NA	NA	NA	NA	0.515657645212038	p.Ile50Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.734	-4.323	2.589	4.12	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I50P	50	I	P	missense	possibly_wt-like	0.735185922555108	0.180075504847378	8	0.063666305301586	0.610402257135268	0.859969587974948	0.55751816302051	0.833367322276137	0.723183587314708	0.818352653719689	1.09103091650254	0.533601346253897	0.64205344188713	0.682379949466253	0.642816248617779	0.572366765977227	0.692391833781825	0.648738950647201	0.654587098289226	0.787670523585634	0.554339269109276	0.633393013950891	0.636893546588357	p.Ile50Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.734	-4.424	2.69	2.182	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50Q	50	I	Q	missense	possibly_wt-like	0.799574345691886	0.112358327328472	2	0.0794493351767406	0.643856510149823	0.955292181233948	0.879023680868626	NA	NA	NA	NA	NA	NA	0.720125010515145	0.690591236106681	0.725331542053152	NA	NA	NA	NA	NA	NA	0.655850930160212	p.Ile50Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.734	-3.69	1.956	7.803	7.803	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50R	50	I	R	missense	low	0.560091634086098	0.105003321831506	8	0.0371242804570856	0.487329381438246	0.63285388673395	0.584259308432528	0.507692788434037	0.607128438434107	0.682500098683083	0.712694682835991	0.431168559987606	0.437958344456518	0.517330851424911	0.569543766422419	0.585089575051674	0.542261354639392	0.59181941711208	0.595008750901074	0.646347628751699	0.503852946199703	0.523468742953894	0.553997957793164	p.Ile50Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.734	-2.563	0.829	12.464	12.464	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50S	50	I	S	missense	possibly_low	0.638956305473126	0.155513505567214	8	0.0549823271763345	0.531192924421313	0.74671968652494	0.853198444621956	0.646051779271439	0.667964534615941	0.554350823720609	0.323119312744005	0.762032903559317	0.658616605586069	0.646316039665675	0.620218574123865	0.713044501052985	0.606042520894638	0.621656630283296	0.538808688861778	0.500826491313074	0.666926945235522	0.642313824484465	0.618780517964433	p.Ile50Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.734	-3.24	1.506	16.481	16.481	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I50T	50	I	T	missense	possibly_wt-like	0.799283873770529	0.1336114206462	7	0.0505003701925552	0.70030496698718	0.898262780553877	0.747946548070729	0.765431826091058	0.719826517435441	0.938111812830723	0.679644073220262	1.03457260054749	NA	0.709453738197995	0.661074713364944	0.662968120108472	0.661074713364944	0.647092467458685	0.707107662090972	0.634001975834306	0.801254318817377	NA	0.650491304373572	p.Ile50Thr	1	0	NA	NA	NA	NA	NA	NA	NA	4.244	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.734	-3.21	1.476	15.804	15.804	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.54	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I50V	50	I	V	missense	wt-like	0.904571249075549	0.186062992968553	6	0.0759598987980015	0.755692583162159	1.05344991498894	0.605517137476167	0.832974081761941	0.981335733049837	0.910678709854001	1.17335909682375	NA	NA	0.923562735487592	0.726551982370791	0.59520355095257	0.692210556522845	0.775350306180003	0.695076832500452	0.818423213214773	NA	NA	0.75802713224113	p.Ile50Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.734	-2.704	0.97	12.292	12.292	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.24	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I50W	50	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.734	-5.478	3.744	1.023	NA	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I50X	50	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I50Y	50	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile50Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	103.4	18	0.784	100.9	58.4	-55.8	-29.1	1.57068062827225	-4.1	1	0	62.98	0	0	0	0	8	18.6134380988575	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.734	-3.088	1.354	11.814	11.814	74.94	0.003466001	0	0.099064086	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51A	51	D	A	missense	possibly_wt-like	0.729957391392477	0.341716682080779	8	0.120815091571943	0.49316416312256	0.966750619662395	0.598787679288173	0.877868720229051	0.94559746600055	1.05742627278862	-0.0213945336457654	0.642841475177906	0.786684000426621	0.951848050874664	0.712098153244603	0.592001832762074	0.712906229299218	0.757822385106103	0.759433202393736	0.372137537547447	0.608180745306198	0.711290077189989	0.772233376934947	p.Asp51Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.192	-2.771	0.579	14.807	14.807	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D51C	51	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.192	-4.302	2.11	14.871	14.871	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51E	51	D	E	missense	possibly_wt-like	0.855882294640176	0.424683096369871	8	0.150148148649218	0.561597330942343	1.15016725833801	1.20794164677913	0.760029703429462	0.281745604613522	0.148871841927818	1.25039151009033	0.994307620912705	1.14675132259071	1.05701910677772	0.803232072701965	0.881822986864428	0.65858442573329	0.432234605063304	0.360985256469683	0.847197733522738	0.781408809992648	0.905219957902509	0.825055335411282	p.Asp51Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.192	-2.332	0.14	15.111	15.111	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D51F	51	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.192	-4.636	2.444	4.103	NA	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51G	51	D	G	missense	possibly_wt-like	0.738742707395037	0.150784900882383	8	0.0533105129572371	0.634256022001497	0.843229392788578	0.424145203738675	0.853004370316396	0.691596220631214	0.657361156419516	0.870435609860638	0.731740894710659	0.83612646402418	0.84553173945902	0.676720511897403	0.508911043700114	0.701444182445527	0.633246848878609	0.583984029027084	0.705269831959334	0.65199684134928	0.737919461411748	0.718836216102687	p.Asp51Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.192	-2.93	0.738	14.549	14.549	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.51	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D51H	51	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.192	-3.326	1.134	15.022	15.022	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D51I	51	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.192	-3.811	1.619	9.163	9.163	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.06	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51K	51	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.192	-2.359	0.167	9.763	9.763	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D51L	51	D	L	missense	wt-like	0.79954168699175	0.0904577112254826	8	0.0319816305090766	0.736858843027092	0.862224530956407	0.740258451992194	0.796594554043626	0.832196309246874	0.962745748658924	0.753303606779906	0.733374954035187	0.887194603322398	0.690665267854887	0.668478402239913	0.659310304519569	0.67544020649611	0.702204508544649	0.717910912614413	0.661516597983716	0.652802224564153	0.765424423824862	0.64105483165039	p.Asp51Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.192	-3.528	1.336	28.14	28.14	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.06	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51M	51	D	M	missense	possibly_wt-like	0.749486885421274	0.318055614776476	5	0.142238795053137	0.47070396991275	1.0282698009298	NA	0.964829511291681	1.01150104768215	0.853483026528233	0.224489255423037	NA	NA	0.693131586181262	0.669993577427574	NA	0.752993690467328	0.790144959018527	0.669993577427574	0.463984433963312	NA	NA	0.64229353523767	p.Asp51Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.192	-3.723	1.531	4.301	4.301	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51N	51	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.192	-2.932	0.74	22.87	22.87	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.21	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D51P	51	D	P	missense	low	0.373124975260926	0.175746118263411	8	0.0621356359956354	0.25134136655299	0.494908583968862	0.389380671545524	0.396651335392233	0.327764866069047	0.348321514889723	0.331863942822835	0.03502417053898	0.498131249127076	0.657862051701989	0.491722004579639	0.492370895593475	0.491073113565803	0.454804865158994	0.44845421794027	0.504092941436066	0.308604195350281	0.555877471840347	0.624579480075373	p.Asp51Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.192	-3.418	1.226	35.847	35.847	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51Q	51	D	Q	missense	possibly_low	0.514955697093689	0.615501846599223	3	0.355360156820773	-0.181537411815532	1.21144880600291	NA	0.815390934097255	NA	NA	-0.193067016797166	NA	NA	0.922543173980977	0.684105021366046	NA	0.684105021366046	NA	NA	0.30801137112885	NA	NA	0.757515059455475	p.Asp51Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.192	-2.804	0.612	7.113	7.113	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D51R	51	D	R	missense	low	0.542015792777764	0.179701324967071	7	0.0679207165902388	0.408893634456744	0.675137951098784	0.596675876065382	0.695162080775918	0.657465514308307	0.525063926788377	0.689935462194642	0.195200084449571	NA	0.434607604862152	0.590997086376218	0.590997086376218	0.628681543383487	0.616507359921314	0.52596487507499	0.637846198914993	0.387550528909962	NA	0.51245036794113	p.Asp51Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.192	-2.978	0.786	13.488	13.488	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D51S	51	D	S	missense	possibly_wt-like	0.76982175657685	0.123540321496532	8	0.0436780995400822	0.684214254565133	0.855429258588566	0.708354242464655	1.01661654529726	0.864622315531676	0.664516156450751	0.640526784146994	0.726153907422421	0.810409150560604	0.727374950740439	0.654367683223552	0.64413103077359	0.776866641590956	0.718107923170714	0.587121865318115	0.619390188651473	0.649243167895622	0.724068286297432	0.659492198551482	p.Asp51Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.192	-2.499	0.307	8.731	8.731	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.86	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D51T	51	D	T	missense	possibly_low	0.680115795851516	0.0968742707637019	8	0.0342502268897577	0.612986584685266	0.747245007017767	0.625613028507198	0.671201922733849	0.730686833429877	0.753318327459611	0.737347848283294	0.46501102267749	0.743469666991069	0.714277716729741	0.639242565228214	0.604764704030695	0.617636313764986	0.65241893617989	0.626066194276539	0.655556518616854	0.520532971821333	0.688015122723533	0.652914138217985	p.Asp51Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.192	-3.142	0.95	6.834	6.834	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.365	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D51V	51	D	V	missense	possibly_low	0.627300963636497	0.197341023787843	8	0.0697705880633399	0.490553123852171	0.764048803420823	0.578960951351676	0.841771044296898	0.793907625126115	0.494911536185504	0.234946694625372	0.605642735504131	0.704569340469336	0.763697781532944	0.628455083148462	0.582568741164072	0.696265808202461	0.683425729138064	0.512741497705038	0.467890683085426	0.589846502419189	0.667063663877735	0.677735269740509	p.Asp51Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.192	-3.193	1.001	11.624	11.624	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D51W	51	D	W	missense	possibly_low	0.660286717919401	0.0883200011300541	3	0.0509915764272648	0.560345064607041	0.760228371231762	NA	NA	NA	NA	0.740779366810392	0.565808274711161	0.674272512236651	NA	0.650745992366143	NA	NA	NA	NA	0.656838320592906	0.570213184574115	0.650745992366143	NA	p.Asp51Trp	0	0	NA	NA	NA	NA	NA	NA	NA	1.471	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.192	-3.413	1.221	11.582	11.582	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D51X	51	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D51Y	51	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp51Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.6	107.2	17.2	0.917	105.1	47.6	-68	-44	37.9679144385027	-3.5	1	0	61.85	0	0	2	29	6	22.2781412568464	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.192	-3.719	1.527	8.27	8.27	43.18	0.003379791	0	0.096600066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.86	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52A	52	D	A	missense	possibly_wt-like	0.742081471209763	0.312337002846683	7	0.118052290682228	0.510703233180143	0.973459709239383	1.06179872010327	0.915401812385167	0.930881414810387	1.0383381888089	0.417740355398541	0.341855880698853	NA	0.48855392626323	0.730208353117799	0.812291613954633	0.730208353117799	0.750604861564043	0.751062093745748	0.53617103003344	0.45983316570902	NA	0.539544803045264	p.Asp52Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.565	-2.979	1.414	8.985	8.985	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52C	52	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp52Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.565	-5.453	3.888	1.188	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52E	52	D	E	missense	wt-like	1.09481461290921	0.422855659242095	7	0.159824416404408	0.781564512906437	1.40806471291198	NA	0.944248493721154	1.26188813506482	1.31789515113315	1.65945922740996	0.287526686323848	1.06511088796138	1.12757370875015	0.861248959218629	NA	0.743506187736764	0.912947922562193	0.873662230428074	1	0.433055789532774	0.861248959218629	0.860491247161914	p.Asp52Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.565	-1.719	0.154	26.02	26.02	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.505	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
D52F	52	D	F	missense	possibly_low	0.61409621933854	0.211099529285094	8	0.0746349543313889	0.467814396861226	0.760378041815854	0.811933604848021	0.767689038011009	0.462705195622708	0.70741522504913	0.322465732996087	0.319184048686477	0.724751572705532	0.796625336789356	0.63402528402021	0.693411659234043	0.66211525007216	0.520986682056855	0.60593531796826	0.500582354553861	0.448658838878226	0.677933680813885	0.69427307038867	p.Asp52Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.565	-4.595	3.03	4.103	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52G	52	D	G	missense	low	0.625711085537479	0.0735057572542429	8	0.0259882097053637	0.574775130492292	0.676647040582666	0.710662886619611	0.611812715827946	0.564079564051398	0.705881508334502	0.567090155332793	0.701920044622448	0.521140877924166	0.623100931586968	0.598610766997863	0.64522942945292	0.590258888875525	0.570705990670339	0.605262704139286	0.591958829856441	0.637298958748708	0.568270305883269	0.607120775039656	p.Asp52Gly	1	0	NA	NA	NA	NA	NA	NA	NA	0.241	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.565	-3.186	1.621	11.766	11.766	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52H	52	D	H	missense	wt-like	0.880945118506032	0.0853223432936635	3	0.0492608778684863	0.784395572036973	0.977494664975092	0.884887518765882	NA	NA	NA	NA	0.793719913336666	NA	0.964227923415549	0.728121418435065	0.728121418435065	NA	NA	NA	NA	0.682544606982018	NA	0.778451143864088	p.Asp52His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.565	-3.12	1.555	17.043	17.043	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.58	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52I	52	D	I	missense	possibly_low	0.583960322374013	0.26632073585646	8	0.0941585991473472	0.399412859210468	0.768507785537557	0.85985592030066	0.590110291847494	0.74650038211059	0.680250724550732	0.430026298223874	0.0052501529305205	0.741695703431209	0.617993105597021	0.599288831884734	0.716211971655791	0.580254436662761	0.660174730068596	0.594022284408581	0.540760294426684	0.293929395199983	0.687059677670968	0.604555379360886	p.Asp52Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.565	-4.23	2.665	8.624	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52K	52	D	K	missense	possibly_wt-like	0.750431479968184	0.154192531802376	4	0.0770962659011881	0.599325575459332	0.901537384477036	NA	0.627501002201575	0.613734411967867	0.836514322341355	NA	NA	NA	0.923976183361938	0.630021425460484	NA	0.597490924866828	0.595059333097831	0.662551926054141	NA	NA	NA	0.758234785632677	p.Asp52Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.565	-2.79	1.225	7.15	7.15	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52L	52	D	L	missense	possibly_low	0.688676766976504	0.339595438860667	8	0.1200651188392	0.453353458252151	0.924000075700857	0.77409716503638	0.614735833962602	0.915657451237556	0.944386875178577	0.287470216125233	0.177537070864426	1.18753844387235	0.607991079534909	0.637470925409946	0.67540996961442	0.591606397140813	0.743138231143253	0.70985960035479	0.487510205205464	0.378844911891037	0.927187631939728	0.599531881205471	p.Asp52Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.565	-3.338	1.773	28.14	28.14	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52M	52	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp52Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.565	-3.606	2.041	4.582	4.582	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52N	52	D	N	missense	wt-like	0.840580100132712	0.125254420789365	4	0.0626272103946825	0.717833023306922	0.963327176958503	NA	0.851364237938148	0.714089734353549	1.00856026330081	NA	NA	NA	0.788306164938345	0.695391445756398	NA	0.700688109021859	0.64427884807029	0.738002938620241	NA	NA	NA	0.690094782490937	p.Asp52Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.565	-2.978	1.413	22.949	22.949	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.58	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52P	52	D	P	missense	possibly_low	0.639115816229725	0.170342488455519	5	0.0761794767286028	0.489806785480557	0.788424846978894	NA	NA	0.842503047909341	0.450699038188356	0.488362591496233	0.767231739983913	0.646782663570783	NA	0.63594014150321	NA	NA	0.707259473900297	0.493352038567796	0.562551106687076	0.669489309728897	0.63594014150321	NA	p.Asp52Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.565	-4.129	2.564	2.293	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52Q	52	D	Q	missense	wt-like	1.03694424527086	0.172632144380159	7	0.0652488174750995	0.909058912985839	1.16482957755588	1.15186480160151	1.10626559516816	0.983464908429505	1.19043407801784	1.20026605824774	NA	0.87457553066602	0.751738744765257	0.817763980369513	0.855142940677192	0.818193344827468	0.776394565487704	0.817763980369513	0.828473981132958	NA	0.75862787466776	0.671728866760758	p.Asp52Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.565	-2.424	0.859	7.857	7.857	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D52R	52	D	R	missense	wt-like	0.902392601249447	0.203995752288336	8	0.0721233898881669	0.7610333546257	1.04375184787319	1.05522253231492	0.801192286016464	0.989193980003727	0.966459010979925	0.432033709023291	0.987770862711168	0.972593850574937	1.01467457837115	0.778695711571129	0.809162818221326	0.677559683557786	0.779204402748174	0.719539369528192	0.541510138295841	0.778187020394084	0.811419894152704	0.803787878295953	p.Asp52Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.565	-4.009	2.444	4.344	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52S	52	D	S	missense	wt-like	0.887855914181707	0.0847755522703405	8	0.0299726839445962	0.829110533130297	0.946601295233118	0.823431749204629	0.94905609355999	0.90333349710702	1.02178278650714	0.923632316007445	0.743402808262303	0.895433152098991	0.84277491070614	0.731117365752105	0.698882206329375	0.745722410352682	0.73709391749423	0.743801696551017	0.725140814009981	0.657744680051834	0.769861651762922	0.717451604218166	p.Asp52Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.565	-3.027	1.462	7.967	7.967	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52T	52	D	T	missense	possibly_low	0.621802413719317	0.360813729573417	8	0.127566917463286	0.371775849872482	0.871828977566151	0.196362497382532	0.891914074764154	0.962955401982506	0.974906611894909	0.390514919899607	0.152811681430167	0.447707111183962	0.957247011216695	0.62405013283244	0.400537380613574	0.719380901362777	0.766335627549503	0.723244077928957	0.526001300001145	0.366658442689683	0.528719364302103	0.774944994276366	p.Asp52Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.565	-3.812	2.247	3.629	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52V	52	D	V	missense	possibly_low	0.701199058439121	0.106843502523471	8	0.0377748825800342	0.627161649062024	0.775236467816217	0.741819845685133	0.799140155282173	0.768790790575735	0.798041424865148	0.689261829403897	0.472655509644987	0.655969722502573	0.683913189553318	0.643283904157607	0.660053178975365	0.676613685825734	0.671107115786775	0.645679577571268	0.637594571585724	0.524300730676547	0.640888230743946	0.637663613442947	p.Asp52Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.565	-3.199	1.634	13.428	13.428	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D52W	52	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp52Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.565	-5.737	4.172	0.555	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D52X	52	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp52Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D52Y	52	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp52Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	108.1	18.8	0.868	109.7	52.9	-64.5	-39.3	28.8770053475936	-4.7	1	0	64.43	0	0	1	3	8	21.7093854786357	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.565	-4.512	2.947	2.794	NA	87.59	0.003233774	0	0.092426655	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V53A	53	V	A	missense	wt-like	0.951014388699258	0.137896940994464	7	0.0521201446325572	0.848860782350427	1.05316799504809	NA	0.859813550373692	0.905820392381507	1.07181017384585	0.813484264893448	0.843243413612721	1.19232050546767	0.970608420319913	0.738313621405171	NA	0.704583099856443	0.738313621405171	0.765741284370947	0.683996350280223	0.706953387780477	0.929763218719354	0.78165573603678	p.Val53Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.001	-2.776	1.775	8.187	6.109	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
V53C	53	V	C	missense	possibly_low	0.50264766355238	0.48113680832562	7	0.181852620204135	0.146223077458035	0.859072249646724	NA	0.591002350355667	0.977802770512816	0.874807498201161	-0.252178157327424	0.85823532589665	-0.062880982863704	0.531744840091492	0.580665660622078	NA	0.580665660622078	0.773617556004385	0.679345457345153	0.285931124107006	0.714342491915854	0.25371999036066	0.561237355594079	p.Val53Cys	0	0	NA	NA	NA	NA	NA	NA	NA	3.861	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.001	-4.944	3.943	1.366	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53D	53	V	D	missense	low	0.346693185964214	0.21346825520709	8	0.0754724254124968	0.198769950329835	0.494616421598593	0.290495847918289	0.233266605207741	0.336186858767916	0.457475829011465	0.207478449054469	0.147403840445562	0.822929035895129	0.278309021413142	0.451477036373194	0.445323818440065	0.415755502643705	0.45893545221592	0.496324010627705	0.457630254306323	0.363993065556598	0.730811413818325	0.433949708097386	p.Val53Asp	0	0	NA	NA	NA	NA	NA	NA	NA	8.435	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.001	-4.096	3.095	3.671	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53E	53	V	E	missense	low	0.36718974285112	0.281959046463955	7	0.106570502406933	0.158315396319193	0.576064089383048	NA	0.327455013745962	0.590111164928112	0.58100323625261	-0.16237320266781	0.162840951145375	0.51255476545318	0.558736271100413	0.55049714545456	NA	0.459174773830448	0.58347325341884	0.55049714545456	0.319476671780118	0.371601595832788	0.563645882435801	0.574793749373031	p.Val53Glu	1	0	NA	NA	NA	NA	NA	NA	NA	6.197	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.001	-3.91	2.909	3.868	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 31, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V53F	53	V	F	missense	possibly_wt-like	0.754008483890738	0.248751778614515	3	0.143616906344488	0.472524519884479	1.035492447897	NA	1.03740972278847	0.571807855709692	0.652807873174049	NA	NA	NA	NA	0.581987179642234	NA	0.786451946474399	0.574496350343791	0.581987179642234	NA	NA	NA	NA	p.Val53Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.001	-4.106	3.105	3.249	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53G	53	V	G	missense	low	0.370853141512034	0.110781975523944	8	0.0391673430631115	0.29408655973821	0.447619723285857	0.370447245082734	0.435088056221636	0.420254569466564	0.465065653934363	0.172049176762811	0.237126047388684	0.484564889417975	0.382229493821501	0.492898051744282	0.483362815860925	0.508791794995098	0.50016666793092	0.49965254004513	0.444396080900321	0.408214691043912	0.54857072013548	0.486143563443434	p.Val53Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.001	-3.79	2.789	5.021	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V53H	53	V	H	missense	low	0.39818958153837	0.243497738613774	8	0.0860894510886945	0.229457357955706	0.566921805121034	0.0563684941240997	0.495817561148307	0.627775614731303	0.76629286147544	0.137720348133455	0.299871935157577	0.293758276427167	0.507911561109612	0.491295306887383	0.333931521082059	0.536787074715508	0.6019458755673	0.631756196165618	0.431572964829354	0.43914042553397	0.445803539059259	0.54926713753431	p.Val53His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.001	-5.055	4.054	1.447	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53I	53	V	I	missense	wt-like	0.797497417695902	3.4149619716501e-05	2	2.41474276764797e-05	0.797450089607337	0.797544745784468	0.797521565123579	NA	NA	NA	0.797473270268226	NA	NA	NA	0.682285193637078	0.686554749144282	NA	NA	NA	0.678015638129873	NA	NA	NA	p.Val53Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.001	-2.645	1.644	19.674	19.674	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.84	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
V53K	53	V	K	missense	low	0.206087110566003	0.130904366728822	7	0.049477199985266	0.109113580538996	0.30306064059301	0.255699429669783	0.147863075098794	0.411789320474713	0.339783406656894	0.100104960647221	NA	0.105419802183921	0.0819497792306974	0.417522194702642	0.428768499697009	0.376385912567227	0.49601486571859	0.444709817415775	0.417522194702642	NA	0.344365681205205	0.335328660244011	p.Val53Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.001	-3.911	2.91	4.061	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53L	53	V	L	missense	wt-like	0.992073585579692	0.123509123338765	8	0.0436670693256233	0.906487702391057	1.07765946876833	0.999132608038267	0.892652846633365	0.954525081500884	0.843839903626359	1.2080811529641	0.895172831165874	1.02276245811903	1.12042180258967	0.772338752708451	0.782476549305883	0.719721462761279	0.76220095611102	0.665764571016913	0.831393214635954	0.732547979499176	0.838440374706352	0.856899216189211	p.Val53Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.001	-2.703	1.702	12.143	8.479	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.515	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
V53M	53	V	M	missense	wt-like	1.05524446935268	0.109756371628109	3	0.0633678707047655	0.931045724994351	1.17944321371101	NA	0.94985670025917	1.04697504766456	1.16890166013431	NA	NA	NA	NA	0.807543269658764	NA	0.746091476567146	0.807543269658764	0.808320905320787	NA	NA	NA	NA	p.Val53Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.001	-3.462	2.461	3.416	3.416	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53N	53	V	N	missense	low	0.355228757518183	0.161959278983041	8	0.0572612522224963	0.242998765452426	0.467458749583939	0.538144589324431	0.295389083371136	0.357161303109145	0.491980167254368	0.521835342884088	0.0515392467662414	0.300463526057588	0.285316801378462	0.459318681148525	0.563149274526237	0.44439291958312	0.46922242008918	0.511455941342443	0.575054445524977	0.316744025395694	0.449414942207869	0.43746935196861	p.Val53Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.001	-4.232	3.231	4.12	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53P	53	V	P	missense	low	0.231920987831849	0.194428592574394	6	0.0793751405357912	0.0763485711138932	0.387493404549805	NA	0.0787393576214427	0.481796983024115	0.268504603041904	-0.0487166641844581	NA	0.383563873241532	0.22763777424656	0.410975280449503	NA	0.344521042131848	0.530350296198247	0.413450388235061	0.361931688260059	NA	0.494172240147856	0.408500172663945	p.Val53Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.001	-3.267	2.266	16.205	16.205	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53Q	53	V	Q	missense	low	0.568662681297447	0.154658936878831	8	0.0546801915190618	0.461491475252333	0.67583388734256	0.552719255392002	0.64160770570295	0.688758817308127	0.835894251472924	0.327445219194999	0.490680582964895	0.461775434655789	0.550420183687889	0.57035028451997	0.570083558411407	0.603993877771362	0.631855237432165	0.662279993019133	0.502442381011268	0.53318479705088	0.536296470373043	0.570617010628534	p.Val53Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.001	-4.334	3.333	2.479	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53R	53	V	R	missense	low	0.198448050785611	0.0972274405753767	8	0.0343750912741305	0.131074109923038	0.265821991648184	0.205699541102241	0.202389824054592	0.21699561401296	0.354896397672028	0.0174559824294751	0.133214304415243	0.193336343074508	0.263596399523841	0.400999819455908	0.404979726770977	0.401521826174713	0.400477812737104	0.451337642917703	0.386649674924128	0.356999430763717	0.391716949254459	0.426560322340614	p.Val53Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.001	-4.306	3.305	2.967	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53S	53	V	S	missense	low	0.469903424082519	0.0358043599533605	8	0.0126587528595326	0.445092724388642	0.494714123776396	0.500115654233451	0.443348227046518	0.439846271486813	0.525922964471101	0.454059730254394	0.470818560702724	0.424124180122741	0.500991804342411	0.524868478042357	0.545056000172713	0.512599594730336	0.509775466428081	0.526341607374703	0.549737690417631	0.523395348710011	0.516017753447592	0.545791703143308	p.Val53Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.001	-3.118	2.117	16.481	16.481	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53T	53	V	T	missense	possibly_low	0.688259555116681	0.0754676947525369	8	0.0266818593600176	0.635964071730483	0.740555038502878	0.717445490655892	0.765046605347656	0.760997289735906	0.718193953812822	0.579494888695234	0.566628963842086	0.705151551343578	0.69311769750027	0.645371496432367	0.648456433190105	0.660897133085331	0.667284774109672	0.610662346079825	0.596592467008859	0.570617679833714	0.667377238807869	0.642286559674628	p.Val53Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.001	-2.36	1.359	7.628	7.628	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53V	53	V	V	synonymous	wt-like	0.915415699496338	0.273311860024778	8	0.0966303348011146	0.726023723472106	1.10480767552057	0.828663225587813	1.16311506987984	1.08367812402822	1.10326912233268	0.81080500669198	0.314923324971964	0.984946909914904	1.0339248125633	0.796496962864839	0.701371219951463	0.844399995917967	0.825544383836583	0.779537654714584	0.682995545992012	0.446558844519777	0.818073170295165	0.813456271015094	p.Val53=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V53W	53	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val53Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.001	-5.495	4.494	0.58	NA	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V53X	53	V	X	nonsense	low	-0.0495635770697267	0.0919963200911473	8	0.0325256108903292	-0.113312602989936	0.0141854488504824	-0.031805470839877	-0.0404945680317468	-0.0260302922430425	-0.0177690429773962	-0.264766909471915	-0.0107992809609248	-0.0525267369863241	0.0476836849534128	0.286961853555835	0.291980418977452	0.289556209060112	0.281285158602704	0.287904639566476	0.281228748978499	0.286019067545194	0.259296718778556	0.318118580973444	p.Val53Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V53Y	53	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val53Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	106.1	21.9	0.89	110.7	48.4	-62.9	-40.3	0	-5.2	1	0	57.3	0	0	0	0	8	19.2723635774131	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.001	-3.349	2.348	6.695	6.695	74.94	0.00089336	0	0.02553371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V54A	54	V	A	missense	possibly_wt-like	0.837466980506919	0.253966944096124	8	0.0897908741837972	0.66148010096631	1.01345386004753	0.346080893713119	0.869730421666572	1.04129789580274	1.00577881416157	0.728243059511552	0.626829234284229	1.03544830311993	1.04632722179565	0.722968870219666	0.47176987802898	0.70915461062589	0.804758896549082	0.736783129813442	0.652155535598114	0.600288749064268	0.845272887007041	0.819685356953733	p.Val54Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.054	-2.05	-0.004	11.356	11.356	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V54C	54	V	C	missense	wt-like	0.984987928257363	0.136719847830193	6	0.0558156441491558	0.875591275951113	1.09438458056361	NA	1.1356526815385	1.02802110787281	1.13629109921936	0.810030076324377	NA	0.921756303047205	0.878176301541926	0.789029310257777	NA	0.831740297072492	0.798247263216953	0.794019493571925	0.682706080185941	NA	0.784039126943628	0.73523188397932	p.Val54Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.054	-3.656	1.602	35.018	35.018	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.395	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54D	54	V	D	missense	low	0.353537416157964	0.133079858705158	7	0.0502994586636373	0.254952288735374	0.452122543580554	0.300743142671675	0.511188409487065	0.494945109162123	0.458464632985395	0.173425481349763	NA	0.284431150460015	0.251563986989713	0.450199240665559	0.450199240665559	0.543872777115077	0.536798827037722	0.496757652134424	0.444910182725875	NA	0.440780010638714	0.42051706652474	p.Val54Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.054	-4.129	2.075	5.817	NA	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V54E	54	V	E	missense	possibly_low	0.671567793103491	0.100479590679058	8	0.0355248999700054	0.601940268607893	0.74119531759909	0.67304280763043	0.702073406800166	0.734377457571062	0.830828357408045	0.629753676205866	0.680292194011284	0.645333406825033	0.476841038376045	0.629599113799161	0.627330679232225	0.631867548366096	0.654229011877486	0.660058337369391	0.615366025314422	0.626639181839422	0.63515958139535	0.53366202786247	p.Val54Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.054	-2.954	0.9	19.091	19.091	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.88	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V54F	54	V	F	missense	possibly_wt-like	0.747558725639434	0.194760103479619	8	0.068858094937516	0.612599339517862	0.882518111761005	0.88236963326802	0.795622129976251	0.532318050779614	0.710260988171631	0.965512785673967	0.394602788538636	0.803573265617182	0.896210163090168	0.697689229599439	0.726923467638005	0.674991935366518	0.555128478278714	0.607183331771541	0.740784753668941	0.485830676064327	0.720386523832361	0.744289355901512	p.Val54Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.054	-3.271	1.217	24.39	24.39	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.65	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54G	54	V	G	missense	low	0.63397185734769	0.1016142501299	8	0.0359260626660192	0.563558068415963	0.704385646279417	0.793536848349131	0.623477204555977	0.545454697453837	0.503978760166037	0.672935469755362	0.547569097023216	0.63691537468537	0.74790740679259	0.613130853387377	0.684658914468694	0.595636021870946	0.561571378986909	0.516717942756166	0.631496058669659	0.56122359200397	0.630625684903808	0.669804584708407	p.Val54Gly	1	0	NA	0.376398327289016	-1.20739012173369	0.112569538089929	0.640227116488104	NA	NA	2.943	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.054	-3.87	1.816	3.072	NA	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.65	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
V54H	54	V	H	missense	possibly_wt-like	0.812566770783944	0.156277394721563	5	0.0698893755887962	0.675586111727911	0.949547429839977	1.04439629950398	0.816375880973357	0.767611862622669	0.826151418121495	NA	NA	NA	0.608298392698218	0.670528907669278	0.804011950862174	0.684559065299707	0.670528907669278	0.658007258437145	NA	NA	NA	0.599686228644623	p.Val54His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.054	-4.084	2.03	16.164	16.164	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54I	54	V	I	missense	wt-like	0.98331242604272	0.255751200919978	8	0.0904217042335597	0.80608914232421	1.16053570976123	1.11251450272307	1.06659423687749	1.11343006324048	1.22697876163144	0.909876120035834	0.812972661452856	1.1759820287391	0.448151033641484	0.816848111999049	0.836420992460724	0.799905516306935	0.840136295682467	0.833790707691164	0.720002354450423	0.69203376073562	0.920963423103486	0.519252528730202	p.Val54Ile	1	0	NA	NA	NA	NA	NA	NA	NA	3.553	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.054	-2.975	0.921	22.1	22.1	81.64	0.003373928	0	0.096432482	4.069e-06	1	245768	not specified	Uncertain significance(Last reviewed: Aug 19, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V54K	54	V	K	missense	wt-like	1.00288552835074	0.154364904933761	7	0.0583444499444084	0.888532507761897	1.11723854893958	NA	1.02891001843791	0.971764421027713	1.31921030881093	0.974927321567039	0.973148371452179	0.93718703776268	0.815051219396711	0.770979993793006	NA	0.782533725815064	0.770656032630978	0.874238994854595	0.744301438954494	0.770979993793006	0.792350018708793	0.703527434126091	p.Val54Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.054	-2.759	0.705	10.863	10.863	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.57	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V54L	54	V	L	missense	wt-like	0.940065117237039	0.254545052677045	8	0.0899952664327128	0.763677636249836	1.11645259822424	0.338621345370085	0.955744366692306	1.02066239039598	1.17381418923929	1.01810567509367	0.929533375205153	1.08353201370376	1.00050758219606	0.777534174720939	0.468220800086066	0.748805591705993	0.794638162110814	0.810475302530999	0.760430187331065	0.749483353269113	0.87117045583304	0.796672531993978	p.Val54Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.054	-2.814	0.76	30.656	30.656	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.435	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.571428571428571
V54M	54	V	M	missense	possibly_wt-like	0.767207780569734	0.284976874055747	3	0.164531474948903	0.444732015346629	1.08968354579284	0.438228590359029	0.938126843212644	NA	NA	NA	NA	NA	0.925267908137529	0.740684209877019	0.5156115883601	0.740684209877019	NA	NA	NA	NA	NA	0.758883551891352	p.Val54Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.054	-3.588	1.534	4.944	4.944	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.65	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V54N	54	V	N	missense	low	0.567484472187057	0.114529222976338	8	0.0404921951052973	0.488121228125705	0.646847716248408	0.766528850977882	0.668764158910992	0.518730732945761	0.577035646605667	0.524416369751349	0.442924866062261	0.426573604226253	0.614901548016287	0.562387854797011	0.671809143498032	0.616512545669139	0.548464544790575	0.548757152900018	0.576018556694004	0.509647308398988	0.517336997086125	0.603002650572965	p.Val54Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.054	-4.248	2.194	2.615	NA	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54P	54	V	P	missense	possibly_low	0.533033886682458	0.311078955130059	6	0.126997451631131	0.284123455357073	0.781944318007842	0.278861513757987	0.137375831767993	0.399615627155322	0.850256199657616	0.899615354934386	NA	NA	0.632478792821443	0.550937517738775	0.439788475434028	0.371551469887408	0.490044247854386	0.668578447530259	0.716169570544703	NA	NA	0.611830787623163	p.Val54Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.054	-4.357	2.303	1.682	NA	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54Q	54	V	Q	missense	possibly_wt-like	0.840913177026038	0.346427710502314	7	0.1309373670358	0.584280653405368	1.09754570064671	0.329309975908813	1.14989165161358	0.987614477843359	1.08527969386222	0.396946964299452	1.12973236940641	NA	0.807617106248426	0.77164836313344	0.463790669137967	0.838304222641518	0.778429732024358	0.77164836313344	0.528403911893422	0.848155970073083	NA	0.699793665242102	p.Val54Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.054	-2.557	0.503	8.6	8.6	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.265	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V54R	54	V	R	missense	possibly_low	0.643037564841432	0.220475538840934	8	0.0779498743000912	0.490258618613829	0.795816511069035	0.34463177840021	0.796373396353454	0.655833930834691	0.886863844186445	0.28895382578584	0.605975621690584	0.816437245683227	0.749230875797002	0.643088220116751	0.471080422989978	0.675338256522927	0.615707145789175	0.684632786458318	0.488064389535124	0.590010572929364	0.727314978502178	0.670469294444327	p.Val54Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.054	-2.93	0.876	11.44	11.44	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.88	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V54S	54	V	S	missense	possibly_wt-like	0.811817920403486	0.175835404289866	8	0.0621672033730211	0.689972440772788	0.933663400034184	1.08044740773488	0.891308191801964	0.637171114131281	0.889394222070065	0.703496758832012	0.924996987423135	0.535305734060229	0.832422947174319	0.698997419113773	0.821164221637302	0.719101599513951	0.606553921382884	0.685742487579015	0.642911856200634	0.747247491620182	0.575899403809364	0.71225235064853	p.Val54Ser	0	0	NA	NA	NA	NA	NA	NA	NA	3.417	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.054	-2.514	0.46	9.168	9.168	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.26	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V54T	54	V	T	missense	possibly_low	0.49917538429878	0.312040556285279	8	0.110322996677272	0.282946284144796	0.715404484452765	0.949059862917438	0.301632088540452	0.244827631500746	0.0398348211767382	0.354215007492484	0.628884879851161	0.65664019825769	0.818308584653532	0.556871915101134	0.758653112942551	0.447270839899151	0.414128094245733	0.313166902970725	0.512441909577773	0.601301920624495	0.641249344555744	0.705163439497156	p.Val54Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.054	-3.055	1.001	6.346	6.346	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.225	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54V	54	V	V	synonymous	wt-like	1.04517324783863	0.0928277334994153	7	0.0350855853727475	0.976406764131542	1.11393973154572	1.02321525411782	1.0008669203411	1.15413677194764	1.0300289927284	1.16075998118518	NA	0.891294257367263	1.05591055718303	0.79393450682254	0.79393450682254	0.769606329545407	0.860101001201441	0.747418082998457	0.813716966929198	NA	0.767632470406553	0.824498568531297	p.Val54=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V54W	54	V	W	missense	possibly_low	0.556196645963393	0.236534822970946	7	0.0894017597125444	0.380972416772303	0.731420875154484	0.576280005659538	0.450235910344479	0.599248648439999	0.963549242429178	0.6167550578826	0.167223270620233	NA	0.520084386367727	0.581293210155415	0.581293210155415	0.515774700814024	0.587954754706789	0.718263286045708	0.610510549663881	0.373761521420728	NA	0.555380915367981	p.Val54Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.054	-5.627	3.573	1.146	NA	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V54X	54	V	X	nonsense	low	0.0342421480949164	0.183274685990103	8	0.0647973866417186	-0.0927583960151687	0.161242692205002	0.460802268085498	-0.0978878472256323	-0.000770804595461224	-0.022701282471768	-0.133011447933608	0.0534613564924625	0.0336868287510852	-0.0196418863432446	0.299702256089416	0.526351614166657	0.263098873255308	0.293673736516776	0.285741598334619	0.330444397858659	0.3176913807869	0.305730775662056	0.284304443605597	p.Val54Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V54Y	54	V	Y	missense	possibly_low	0.633767507217835	0.250722087062205	7	0.0947640415082397	0.448033398832226	0.819501615603443	NA	0.885174573408294	0.721704742544988	0.59265944263377	0.583147916465347	0.125106703286781	0.832005403344801	0.696573768840862	0.644022364790175	NA	0.716274104660562	0.648013647588481	0.555608992727639	0.597957011066344	0.353003415586218	0.735699885358143	0.644022364790175	p.Val54Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.3	108	22.2	0.979	113.1	46.5	-63.5	-54.9	11.5151515151515	-5.3	1	0	57.28	0	0	0	0	8	22.0528582696212	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.054	-2.896	0.842	13.231	13.231	81.64	0.003373928	0	0.096432482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R55A	55	R	A	missense	wt-like	0.932598120233808	0.293133602108562	7	0.110794087442259	0.715445699146999	1.14975054132062	NA	0.904748494000236	0.914003629023009	0.314870763926541	1.19326485672021	1.00094209829585	1.14529498514341	1.05506201452741	0.784678762707112	NA	0.725297352632995	0.742327109965864	0.43378433955085	0.825858767523629	0.784678762707112	0.904435584175575	0.824072389631257	p.Arg55Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.843	-2.672	0.829	8.985	8.985	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R55C	55	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg55Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.843	-5.482	3.639	1.352	NA	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55D	55	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg55Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.843	-2.916	1.073	13.979	13.979	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55E	55	R	E	missense	wt-like	0.9236992163219	0.151100418861536	6	0.0616864876885959	0.802795922119478	1.04460251052432	NA	0.862341358855194	0.963548654578273	1.14537455919743	NA	0.791563368797356	0.748456972211313	1.03091038429183	0.736187483385198	NA	0.705748377024513	0.766626589745883	0.798003058944796	NA	0.681481705073859	0.690701252363473	0.811942280272888	p.Arg55Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.843	-2.657	0.814	9.73	9.73	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.84	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R55F	55	R	F	missense	low	0.175198514601887	0.382497191652815	2	0.270466358002516	-0.354905806112761	0.705302835316535	NA	-0.0952678434006288	NA	NA	NA	NA	NA	0.445664872604403	0.391155255052575	NA	0.264306650925125	NA	NA	NA	NA	NA	0.518003859180025	p.Arg55Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.843	-4.661	2.818	4.301	NA	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.225	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55G	55	R	G	missense	wt-like	0.779239240093485	0.0881009989201127	8	0.0311484068828602	0.71818948442728	0.840288995759691	0.679921349628497	0.846616308838786	0.810700331246661	0.926552959981601	0.687673616542165	0.727610975527389	0.721825616547807	0.833012762434976	0.684009766681802	0.630603327998895	0.698499393612606	0.69166175320415	0.70203850935941	0.637001314003554	0.649961316972007	0.676357780159454	0.712548584217164	p.Arg55Gly	1	1	NA	NA	NA	NA	NA	NA	NA	1.931	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.843	-2.952	1.109	26.189	26.189	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R55H	55	R	H	missense	wt-like	0.896960662201869	0.221875010741551	7	0.0838608715088468	0.732596374332388	1.06132495007135	0.994145293935752	0.99102865739861	1.02518644708669	1.21875894106486	0.687154241472544	NA	0.581276873681962	0.781174180772673	0.765071055902547	0.780103702363729	0.765071055902547	0.796856996854516	0.830185892713246	0.636807307768328	NA	0.600659155873169	0.686512757301418	p.Arg55His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.843	-3.741	1.898	8.17	8.17	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.42	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R55I	55	R	I	missense	low	0.269514288306709	0.165250167751436	8	0.0584247571046274	0.155003868576138	0.384024708037279	0.301008971144772	0.278603657303257	0.330716204892182	0.405632515733417	-0.0308873872504262	0.180595403836584	0.174644401580882	0.515800539213001	0.443490418134124	0.450325715611103	0.436655120657146	0.456252356551985	0.473588045688363	0.368591597634042	0.380352280689889	0.381649593065739	0.553229361458181	p.Arg55Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.843	-4.363	2.52	11.897	NA	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55K	55	R	K	missense	wt-like	0.863712811462477	0.0348679994036157	2	0.0246553988247052	0.815389117741584	0.91203650518337	NA	0.888368210287182	0.839057412637772	NA	NA	NA	NA	NA	0.711657935555639	NA	0.717746317514229	0.705569553597049	NA	NA	NA	NA	NA	p.Arg55Lys	1	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.843	-2.11	0.267	23.72	23.72	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	.	D	0.571428571428571
R55L	55	R	L	missense	possibly_low	0.568262237416401	0.246657629255137	7	0.0932278208551232	0.385539066183208	0.750985408649595	NA	0.472731952970783	0.692071460775908	0.801417048385725	0.0564143019035142	0.68970191247805	0.608553671271012	0.656945314129817	0.624119050411002	NA	0.526144997866274	0.633479931577775	0.647159962468751	0.401202080948208	0.631276975092124	0.61535025883378	0.624119050411002	p.Arg55Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.843	-3.302	1.459	11.834	11.834	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.835	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R55M	55	R	M	missense	possibly_low	0.660005490686043	0.188732330225115	6	0.0770496511696643	0.508990949372127	0.81102003199996	NA	0.3376247352233	0.631388968292551	0.846304195984465	0.844625037107045	0.696741890149523	0.603348117359376	NA	0.623646684857569	NA	0.463862844279574	0.6037180537187	0.666845290228544	0.695628606683315	0.634746787824487	0.61254658189065	NA	p.Arg55Met	1	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.843	-4.082	2.239	4.019	4.019	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
R55N	55	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg55Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.843	-2.51	0.667	16.19	16.19	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.725	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
R55P	55	R	P	missense	low	0.386964643700489	0.119462523636613	8	0.0422363802805535	0.304182859513267	0.469746427887712	0.514999972423911	0.349937641831188	0.282391951539715	0.468668910623525	0.346824023873443	0.267793090135289	0.581806704626329	0.283294854550515	0.485385820412273	0.552137609266968	0.469538887005022	0.432551607504778	0.501232753819525	0.509681097612737	0.423329638896271	0.600944519319153	0.436453833102986	p.Arg55Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.843	-4.298	2.455	2.322	NA	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55Q	55	R	Q	missense	possibly_wt-like	0.79077463762009	0.339193170005725	4	0.169596585002863	0.458371439113494	1.12317783612669	NA	NA	0.647017427648217	NA	1.0922832618127	0.379378495415982	1.04441936560346	NA	0.699760696012204	NA	NA	0.611383070092186	NA	0.788138321932222	0.478327037759867	0.850104641987859	NA	p.Arg55Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.843	-2.565	0.722	6.636	6.636	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R55R	55	R	R	synonymous	wt-like	1.08405577895119	0.108081714144754	2	0.0764253129940217	0.934264917975707	1.23384663992667	1.00763046595717	NA	NA	NA	1.16048109194521	NA	NA	NA	0.800066210906329	0.786519630564301	NA	NA	NA	0.813612791248356	NA	NA	NA	p.Arg55=	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R55S	55	R	S	missense	wt-like	0.871990701486938	0.153664275062653	8	0.0543285254614586	0.765508748249311	0.978472654724564	0.977760191151496	0.861405573834917	0.563199825873875	0.716268088948538	0.953580543989056	0.958487999210555	0.973134123667524	0.972089265219539	0.750040953360717	0.772308055199879	0.705316995879015	0.570274520914964	0.609817755075437	0.736327610031316	0.763754296690117	0.811710881670726	0.782399487510285	p.Arg55Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.843	-2.679	0.836	8.077	8.077	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R55T	55	R	T	missense	possibly_wt-like	0.856625746625951	0.239647721960308	6	0.0978357728038551	0.664871155530752	1.04838033772115	0.921824317602788	1.11812109977058	0.837450624396883	0.815485004426557	0.425959323935851	NA	NA	1.02091410962305	0.725238290175679	0.745695080003505	0.823658532926271	0.704781500347854	0.653329486272083	0.539241125686148	NA	NA	0.806921670743597	p.Arg55Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.843	-3.165	1.322	15.804	15.804	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.75	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	.	D	0.785714285714286
R55V	55	R	V	missense	low	0.378581898794198	0.0654385692355871	8	0.0231360280288145	0.333236117112413	0.423927680475984	0.41202623061926	0.387610677673624	0.462128347861712	0.348455069869372	0.321106612391653	0.273534227983403	0.365369858451416	0.458424165503148	0.493490097051806	0.503145120857206	0.486905522507807	0.520703765652082	0.448512788682431	0.500074671595806	0.426159288951037	0.484373063991789	0.524412189246674	p.Arg55Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.843	-3.568	1.725	19.507	19.507	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.88	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R55W	55	R	W	missense	low	0.261286021411642	0.199985043587282	8	0.0707053902282271	0.122706003051467	0.399866039771817	0.431510849057371	0.0860754288189852	0.108509553391365	0.268271925642158	0.342152756840244	0.0211652307827384	0.210587109105899	0.622015317654376	0.407178222532012	0.512415444788998	0.347902847491072	0.347270557176242	0.413348347202799	0.50793620267292	0.301773502432303	0.401008097861226	0.606575527551396	p.Arg55Trp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.843	-4.26	2.417	13.184	13.184	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.225	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R55X	55	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg55Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R55Y	55	R	Y	missense	low	0.486127254413011	0.202015838653523	8	0.0714233847094969	0.346139992728449	0.626114516097574	0.231174751653934	0.592524761671223	0.674048854318668	0.632089667984483	0.366255237647783	0.170902912552461	0.548543000827699	0.673478848647841	0.577134322721177	0.417100233764476	0.581367466617038	0.624640699863131	0.572901178825316	0.516939390994034	0.375575116438041	0.583028908230221	0.632422985997454	p.Arg55Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	41.5	111.3	21.7	0.943	114.9	49.2	-48.3	-54.6	53.5849056603774	-6.9	1	0	59.32	1	4	2	4	8	24.6549779529409	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.843	-3.869	2.026	10.396	10.396	36.72	0.003441266	0	0.098357105	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.675	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56A	56	F	A	missense	possibly_wt-like	0.727967493185589	0.374737766597004	7	0.141637562468492	0.450362971889304	1.00557201448187	0.937404438524318	0.65722630824875	0.707829316160081	0.86726406225344	1.31067413389493	0.106347979672539	NA	0.509026213545068	0.641208410552058	0.753107735698962	0.611193790690784	0.641208410552058	0.676037271884286	0.869715573861973	0.343757753017809	NA	0.54982696955421	p.Phe56Ala	0	1	NA	NA	NA	NA	NA	NA	NA	6.235	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.36	-2.936	1.576	6.469	6.469	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56C	56	F	C	missense	low	0.532925127708923	0.133738205583739	5	0.0598095437748165	0.415700575978511	0.650149679439335	0.631068023190248	0.653129875661782	0.515336001291025	0.316354103740118	NA	NA	NA	0.548737634661442	0.569771953649252	0.607360062411394	0.609305404209345	0.546799590291544	0.434434860512227	NA	NA	NA	0.569771953649252	p.Phe56Cys	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.36	-3.833	2.473	12.352	12.352	28.04	0.002703064	0	0.077258069	4.285e-06	1	233380	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	1	2	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.38	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F56D	56	F	D	missense	low	0.255722153931697	0.173864537428521	7	0.0657146182641639	0.126923868876138	0.384520438987256	0.362989714560456	0.283560689149298	0.225778893858684	0.328787539135788	0.036460253278384	0.0375560044361906	NA	0.514921983103079	0.438940228913511	0.479814697949746	0.438940228913511	0.404785593964814	0.43988756276749	0.393748488972542	0.309852067133791	NA	0.552788108359038	p.Phe56Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.36	-4.258	2.898	2.667	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56E	56	F	E	missense	possibly_wt-like	1.00318888973507	0.327958296116934	2	0.23190153513067	0.548670232919412	1.45770754655074	1.23509042486574	0.771287354604405	NA	NA	NA	NA	NA	NA	0.779256875728701	0.894739737993767	0.663774013463634	NA	NA	NA	NA	NA	NA	p.Phe56Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.36	-4.135	2.775	1.691	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56G	56	F	G	missense	low	0.247631566979093	0.0728172652832526	8	0.0257447910346238	0.19717270376172	0.298090430196465	0.143838966613108	0.201106679635932	0.277294296930564	0.394460635490726	0.219156157675734	0.266002163598953	0.224383094158332	0.254810541729393	0.42229729122566	0.375547917985883	0.400930318192465	0.430051450249587	0.468688600389755	0.461992320216296	0.422446940116744	0.408438524258851	0.422147642334577	p.Phe56Gly	0	1	NA	NA	NA	NA	NA	NA	NA	11.142	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.36	-3.921	2.561	2.195	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56H	56	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.36	-3.77	2.41	7.906	7.906	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56I	56	F	I	missense	low	0.550791887450069	0.220476212136794	8	0.0779501123461254	0.398012474660813	0.703571300239326	0.677328929524369	0.587884861644642	0.564934962197665	0.24235913817104	0.868954225951279	0.3217936509148	0.380461651280058	0.762617679916703	0.575177036794854	0.629369915386331	0.579228550792255	0.571125522797453	0.401984254320382	0.704716479031961	0.449945040548287	0.492501403896133	0.677192790802426	p.Phe56Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.36	-3.16	1.8	7.546	7.546	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F56K	56	F	K	missense	low	0.510325544941134	0.217520517653247	7	0.0822150278235039	0.349187051419108	0.67146403846316	NA	0.303938825480997	0.282144471112581	0.403125348998572	0.677276309085494	0.597652758696754	0.878696058897007	0.429445042316533	0.509857480933629	NA	0.448334206807377	0.43243023011991	0.472488523852735	0.633117526363086	0.585908461057231	0.76084716394818	0.509857480933629	p.Phe56Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.36	-4.086	2.726	1.775	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56L	56	F	L	missense	wt-like	0.814433488037181	0.147963467911029	8	0.0523129857638832	0.711901920016214	0.916965056058149	0.994558998890872	0.850987067060458	0.782289110710231	0.947122430344268	0.743655654537174	0.510429035190167	0.81366092097818	0.8727646865861	0.705786760941812	0.780300533467111	0.700514239594863	0.677727400134121	0.71105928228876	0.65791272286198	0.542918269822161	0.725819668359527	0.732513910882711	p.Phe56Leu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.36	-1.972	0.612	15.654	15.654	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	low	1.29	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
F56M	56	F	M	missense	possibly_low	0.666811234978715	0.100365038278128	7	0.0379344188013436	0.592461140353623	0.741161329603807	0.655830951863497	0.72193204050543	0.704024300189684	0.800116602764907	0.47418408907218	NA	0.636085882313745	0.675504778141563	0.633440505149226	0.619141682412321	0.641022044292176	0.639342231100154	0.646589650037485	0.557254899692682	NA	0.630178925792999	0.633440505149226	p.Phe56Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.36	-2.471	1.111	5.426	5.426	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F56N	56	F	N	missense	possibly_low	0.451649531966239	0.365091410675818	7	0.137991582636281	0.181190999829445	0.722108064103032	NA	0.188491636627136	0.46021550791853	0.57347813466618	0.168025859414616	1.20786516991356	0.229120890705488	0.334349524518164	0.462095941893259	NA	0.39511499567102	0.519765608591896	0.547197000556095	0.442893219678249	0.886665493634984	0.410990270175997	0.462095941893259	p.Phe56Asn	0	1	NA	NA	NA	NA	NA	NA	NA	9.192	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.36	-3.553	2.193	10.138	10.138	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56P	56	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.36	-4.478	3.118	0.954	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56Q	56	F	Q	missense	low	0.242971289802846	0.341445302534244	5	0.15269898141291	-0.0563132142424093	0.5422557938481	NA	0.416875545128801	0.386291748560213	0.498988000394004	-0.348369550675429	NA	NA	0.261070705606639	0.483509518789565	NA	0.500396133889831	0.483509518789565	0.514529237366348	0.25	NA	NA	0.42529179747821	p.Phe56Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.36	-4.464	3.104	1.097	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56R	56	F	R	missense	low	0.388319361494743	0.141486973593012	5	0.0632748981769385	0.264302839942504	0.512335883046981	0.471039270921032	0.141683481942586	NA	NA	0.414307939728458	0.490562370627718	NA	0.424003744253919	0.531222139739304	0.531222139739304	0.373537224122043	NA	NA	0.534888892940546	0.533126533418267	NA	0.507124599554311	p.Phe56Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.36	-4.351	2.991	1.419	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56S	56	F	S	missense	low	0.338433545635924	0.0795686443566165	3	0.0459389782383462	0.248394802802196	0.428472288469652	NA	0.253599233413139	0.350297080570523	0.41140432292411	NA	NA	NA	NA	0.465855845243098	NA	0.425128502057228	0.465855845243098	0.476119280627388	NA	NA	NA	NA	p.Phe56Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.36	-3.326	1.966	7.203	7.203	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F56T	56	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.36	-3.866	2.506	2.69	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56V	56	F	V	missense	possibly_low	0.61434594528958	0.208828374999802	8	0.0738319800332636	0.469637923517103	0.759053967062058	0.644591938019947	0.631041677299595	0.74513236059274	0.801193482064306	0.598897695519467	0.142659828196213	0.78007053370029	0.571180046924085	0.608817286425073	0.613794423530422	0.599123116499014	0.65950378054664	0.64706191711393	0.603840149319724	0.361654871477947	0.707728107707101	0.581043611601786	p.Phe56Val	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.36	-2.676	1.316	6.28	6.28	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.755	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F56W	56	F	W	missense	possibly_low	0.604322166920055	0.186324048250004	4	0.0931620241250022	0.421727954908199	0.786916378931911	NA	NA	NA	NA	0.334591436235057	0.707898868266345	0.628817734020985	0.745980629157834	0.6332550533925	NA	NA	NA	NA	0.505111763400117	0.640245757641013	0.626264349143987	0.668836864385146	p.Phe56Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.36	-5.103	3.743	1.091	NA	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F56X	56	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe56Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F56Y	56	F	Y	missense	wt-like	0.992851269202128	0.337478371480974	7	0.127554834828819	0.742848386883688	1.24285415152057	0.985737270433949	0.943256958708247	0.738795552565204	0.853041478002151	1.65945922740996	1.13884903366058	NA	0.630819363634808	0.743049106782911	0.776103362211551	0.743049106782911	0.656395877446192	0.669799935640943	1	0.852649324907709	NA	0.610997342538504	p.Phe56Tyr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	38.9	110.2	24.2	0.922	114.6	41.7	-49.9	-58.3	0	-6.2	1	0	51.81	0	0	0	0	8	22.8158128906248	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.36	-2.796	1.436	12.601	12.601	28.04	0.002703064	0	0.077258069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.63	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L57A	57	L	A	missense	low	0.190783106320341	0.223267520370155	8	0.0789369888362211	0.036069451153307	0.345496761487374	0.199770278371639	0.264652132835679	0.294425388501436	0.518389165098935	-0.195886207079572	-0.0160889150565151	0.1082935838909	0.352709424000223	0.416191212732602	0.402158722789607	0.430223702675596	0.438453436293004	0.523037648048899	0.306958296915111	0.283411951359472	0.345913481045187	0.471317165734207	p.Leu57Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.137	-3.437	2.3	2.304	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57C	57	L	C	missense	low	0.368016297054055	0.296650649731769	6	0.121107120617989	0.130650702371449	0.605381891736661	0.296211624354701	0.351359961141048	0.336048312410554	0.919716799012757	0.0178782334829931	0.286882851922277	NA	NA	0.453455376234682	0.448043250655561	0.470194552269861	0.458867501813804	0.699040500430587	0.38680740166537	0.432738461139368	NA	NA	p.Leu57Cys	0	0	NA	NA	NA	NA	NA	NA	NA	6.871	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.137	-5.039	3.902	0.597	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57D	57	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.137	-4.318	3.181	1.033	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57E	57	L	E	missense	low	0.195574611703541	0.126211688220226	5	0.0564435828830869	0.0849472220942895	0.306202001312793	NA	0.139123612840419	0.200808391137236	0.385930909831571	0.0405998868962186	NA	NA	0.211410257812262	0.395294798721293	NA	0.372357167547412	0.392538749419343	0.464947876055864	0.395294798721293	NA	NA	0.400349934065441	p.Leu57Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.137	-4.14	3.003	1.101	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57F	57	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.137	-1.827	0.69	19.225	19.225	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
L57G	57	L	G	missense	low	0.193016685314195	0.0917686907989956	8	0.0324451317822906	0.12942539554725	0.256607975081141	0.217846842533987	0.180838686734644	0.255536796304032	0.349280991844063	0.0385594126667978	0.167383963549974	0.122476987636093	0.212209801243971	0.397642053805398	0.410759127559711	0.391587114566353	0.419380430493054	0.448874998037348	0.394532604410319	0.373840722577271	0.353552568591013	0.400751503200477	p.Leu57Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.137	-4	2.863	1.413	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57H	57	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.137	-5.054	3.917	0.852	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57I	57	L	I	missense	low	0.328029717997744	0.327359621532222	4	0.163679810766111	0.00722318389983506	0.648836252095653	NA	-0.0838416695770102	0.633187372088337	0.544235934169393	NA	0.218537235310256	NA	NA	0.466712780845589	NA	0.269573924760347	0.604600085288616	0.534372788459958	NA	0.399052773231219	NA	NA	p.Leu57Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.137	-2.556	1.419	7.479	7.479	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.445	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L57K	57	L	K	missense	low	0.178881768652197	0.141235790161436	8	0.0499343924846958	0.0810121577923062	0.276751379512089	0.151111292294975	0.18677074483219	0.308962684457392	0.369069289904943	-0.0761915696166311	0.185363513889259	0.0548483080997197	0.251119885355731	0.388512022716544	0.379007919782815	0.3943216935154	0.445583288890292	0.457553186649802	0.351668771770845	0.382702351917688	0.31712820862297	0.420294017341977	p.Leu57Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.137	-4.002	2.865	2.547	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57L	57	L	L	synonymous	wt-like	1.09145347970546	0.12121572539139	8	0.0428562307053491	1.00745681100984	1.17545014840109	1.20430890398792	1.01532473144541	1.10293964955607	0.913199039902685	1.21943700804806	0.963484996070607	1.08161661742899	1.23131689120397	0.835313151267416	0.880094613145312	0.776271137145909	0.834991246460041	0.696182127127652	0.835635056074791	0.76621717997437	0.870138836054685	0.912596058972774	p.Leu57=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L57M	57	L	M	missense	possibly_wt-like	0.818117426283554	0.306322003924465	2	0.216602366201642	0.39358458956218	1.24265026300493	0.601515060081912	NA	NA	NA	NA	NA	NA	1.0347197924852	0.703577502318959	0.593299456501724	NA	NA	NA	NA	NA	NA	0.813855548136193	p.Leu57Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.137	-2.881	1.744	6.31	6.31	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.445	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L57N	57	L	N	missense	low	0.195549749765955	0.137044657481213	8	0.0484526033151767	0.100584392311003	0.290515107220908	0.0567910584740838	0.198622192378831	0.181642045719459	0.426828542034613	0.0181637671350949	0.351886911489077	0.145527802215879	0.184935678680606	0.386983593711537	0.334132567277489	0.399785011379766	0.383138568115235	0.482883595690207	0.386914059285489	0.464777186837905	0.365967585024376	0.387053128137584	p.Leu57Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.137	-4.369	3.232	1.16	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57P	57	L	P	missense	low	0.276809990483964	0.180822794791272	6	0.0738205968504346	0.132124279339861	0.421495701628067	NA	0.370517259363184	0.265267470914555	0.0590310188566773	0.547313865674566	0.0978472341447802	NA	0.320883093950022	0.439742658561055	NA	0.479025744341385	0.424152863815963	0.321585425048568	0.584571637579112	0.339567967702677	NA	0.455332453306147	p.Leu57Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.137	-4.435	3.298	0.636	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57Q	57	L	Q	missense	low	0.371169418480973	0.109532902287897	2	0.0774514579708158	0.219367350308057	0.52297148665389	NA	NA	NA	NA	0.293717960510157	NA	NA	0.448620876451789	0.504666240219647	NA	NA	NA	NA	0.489843974070537	NA	NA	0.519488506368757	p.Leu57Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.137	-4.436	3.299	1.153	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57R	57	L	R	missense	low	0.213797439996791	0.175661583791814	8	0.0621057485465803	0.0920724096125924	0.335522470380989	0.266920969073324	0.0984212064588021	0.28689127823352	0.297679439897845	-0.0418629542141717	0.540613119398124	0.102950256383234	0.158766204743647	0.400077309301809	0.434107444650671	0.353594043209035	0.434758313360603	0.426245057902684	0.364491808193501	0.557795180600426	0.34303560015352	0.373909560700934	p.Leu57Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.137	-3.457	2.32	7.256	7.256	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57S	57	L	S	missense	low	0.239096771141433	0.253174634686246	6	0.103358111799473	0.0365185945044015	0.441674947778465	NA	0.303077891600776	0.316999245214771	0.548332066963323	-0.189298412662469	NA	0.103401668305773	0.352068167426424	0.448731085340092	NA	0.447937330777732	0.449524839902452	0.536169153809723	0.309419087330487	NA	0.343278727632471	0.470995095866	p.Leu57Ser	1	0	NA	NA	NA	NA	NA	NA	NA	6.423	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.137	-3.268	2.131	4.639	4.639	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.65	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L57T	57	L	T	missense	possibly_low	0.607322864361532	0.571658461331681	3	0.330047166534373	-0.0395576952453335	1.2542034239684	NA	NA	0.365522244580491	0.196299550394986	NA	1.26014679810912	NA	NA	0.473323064421238	NA	NA	0.473323064421238	0.381784751113855	NA	0.912433680360448	NA	NA	p.Leu57Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.137	-3.78	2.643	1.732	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L57V	57	L	V	missense	low	0.310628146568529	0.0972732647701474	8	0.0343912925735629	0.243222451742566	0.378033841394492	0.356502082624067	0.393254627679876	0.30952106374601	0.422958730769084	0.188282976367969	0.367607661271512	0.148388141780611	0.298509888309105	0.461492767105295	0.476728035011409	0.489507288475499	0.445857147387312	0.481186483995531	0.450460019138859	0.472525515071732	0.367508145015358	0.444095554244904	p.Leu57Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.137	-2.741	1.604	8.618	8.618	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.65	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
L57W	57	L	W	missense	low	0.173295345054726	0.197318168644228	8	0.0697625075498222	0.0365633427858707	0.310027347323581	0.33572250323108	0.232675488501508	0.471681107884545	0.133014717028713	-0.121729688782875	-0.0748936939399668	0.230781448075746	0.179110878439055	0.398006134469091	0.466841599064447	0.415483007790365	0.525388940327374	0.354031089906075	0.334658561663562	0.254428681807299	0.41188463540413	0.384127633534053	p.Leu57Trp	1	0	NA	NA	NA	NA	NA	NA	NA	8.366	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.137	-5.237	4.1	0.893	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	4	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L57X	57	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L57Y	57	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu57Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.3	109.1	26.9	0.882	119.2	45.5	-61.6	-40.8	0	-5.3	1	0	51.41	0	0	0	0	9	22.3464166671079	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.137	-3.977	2.84	4.459	NA	19.35	0.00320597	0	0.091631956	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58A	58	D	A	missense	low	0.57865197996408	0.0901316955236128	8	0.0318663665522939	0.516195049203432	0.641108910724728	0.722202347759109	0.57423634414622	0.588143700305183	0.678366040550958	0.461714965628726	0.481440411777232	0.596896974263954	0.526215055281258	0.57772255973699	0.650719634103386	0.572936813924013	0.582508305549968	0.593195753335793	0.552597210409282	0.528630569021709	0.609072038842879	0.558460031917701	p.Asp58Ala	1	0	NA	0.223934197830216	-1.76987997534523	0.0442779643684058	0.403590431292027	NA	NA	1.03	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.861	-3.086	1.225	6.109	6.109	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D58C	58	D	C	missense	possibly_low	0.482495866037803	0.189293784782447	2	0.133850918856135	0.220152885782185	0.744838846293422	NA	0.348644947181668	0.616346784893939	NA	NA	NA	NA	NA	0.532641777179517	NA	0.468942976527074	0.59634057783196	NA	NA	NA	NA	NA	p.Asp58Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.861	-4.111	2.25	11.633	11.633	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58E	58	D	E	missense	wt-like	0.997160121529623	0.289057992533277	8	0.102197433338225	0.796856832874268	1.19746341018498	0.445917133278205	1.13764523889875	1.23401462912226	1.28304452905619	0.685971406855506	1.12370386239862	0.970424460008925	1.09655971261853	0.838786680173887	0.519269616545288	0.832658832481706	0.89927729293876	0.858378436404215	0.636365474295045	0.845184683607568	0.810251474727256	0.844914527866069	p.Asp58Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.861	-1.788	-0.073	16.29	16.29	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.22	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D58F	58	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp58Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.861	-4.672	2.811	1.811	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58G	58	D	G	missense	low	0.575717098482727	0.066764711652738	8	0.0236048901768078	0.529452363877161	0.621981833088294	0.636772358565339	0.533826410179543	0.610378035533438	0.656296463191272	0.529625240221113	0.633451695238603	0.471846879552094	0.533539705380417	0.580740686512281	0.610074051238562	0.554308514446742	0.593413190011043	0.583517106170925	0.577964266853636	0.603552779209161	0.54172088405103	0.562138823197957	p.Asp58Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.861	-3.703	1.842	3.194	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D58H	58	D	H	missense	possibly_wt-like	0.734919921149763	0.191971378083704	6	0.0783719869206639	0.581313649388418	0.888526192911109	0.928691415540266	0.645229956194608	0.777135890218659	0.967535911230544	NA	0.471323897917974	0.619602455796529	NA	0.648250525816873	0.748962283954866	0.605663674287139	0.675199990455076	0.720011645792827	NA	0.523644415622641	0.621301061178669	NA	p.Asp58His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.861	-3.626	1.765	11.333	11.333	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D58I	58	D	I	missense	low	0.230266000450678	0.0509467765302785	3	0.0294141351441	0.172615354931848	0.287916645969508	NA	0.214183226866794	0.189301445417027	NA	NA	NA	NA	0.287313329068211	0.40695838639337	NA	0.40695838639337	0.386895139556914	NA	NA	NA	NA	0.438472104121465	p.Asp58Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.861	-3.727	1.866	5.727	5.727	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58K	58	D	K	missense	low	0.517332181672094	0.159968591843583	8	0.0565574380347304	0.406481640066167	0.628182723278022	0.581467480400392	0.361191667194236	0.863488808290095	0.506959441954826	0.379975515671547	0.46725665984833	0.426939259531351	0.551378620485977	0.521852109447916	0.58376128882929	0.474726803297104	0.717551991753006	0.518025125348485	0.522064433841381	0.521639785054452	0.517533936617525	0.571098383648099	p.Asp58Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.861	-2.195	0.334	9.763	9.763	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D58L	58	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp58Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.861	-3.942	2.081	3.535	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58M	58	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp58Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.861	-5.088	3.227	0.831	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58N	58	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp58Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.861	-2.23	0.369	15.797	15.797	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.32	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D58P	58	D	P	missense	low	0.459695187601921	0.240754718991547	8	0.0851196472007923	0.292863744711612	0.626526630492229	0.612071731065677	0.282129978565012	0.272203445632909	0.458261047309684	0.484410429266922	0.971682678465117	0.321455553291219	0.275346637218827	0.478694739350902	0.598322072673126	0.438280695412383	0.427554629695272	0.496668369322573	0.561074824593535	0.770257593747783	0.460721109379232	0.432461856391805	p.Asp58Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.861	-4.209	2.348	1.435	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58Q	58	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp58Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.861	-2.757	0.896	8.228	8.228	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.39	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D58R	58	D	R	missense	low	0.449460436000104	0.0827446904256412	8	0.0292546658535763	0.392122344547341	0.506798527452867	0.460080602533071	0.439368890280849	0.509659911165323	0.596840423632652	0.326976248702727	0.409456928638777	0.475250936350585	0.378049546696848	0.518386725047094	0.526008262642343	0.510765187451846	0.54401573791296	0.557442568388454	0.502267202792367	0.493151876052875	0.543554286551713	0.484044193121858	p.Asp58Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.861	-3.017	1.156	9.732	9.732	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D58S	58	D	S	missense	possibly_wt-like	0.852985110677207	0.401759393426729	5	0.17967226286025	0.500833946450304	1.20513627490411	NA	0.885095240146716	0.977189126766616	1.31337711982333	0.207689382352729	NA	NA	0.881574684296643	0.736938715114703	NA	0.716237533362118	0.773316592918065	0.871680840833933	0.457709045872328	NA	NA	0.736938715114703	p.Asp58Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.861	-3.253	1.392	6.658	6.658	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D58T	58	D	T	missense	possibly_low	0.554198667326702	0.23321945770696	3	0.134649316687372	0.290290856076525	0.818106478576879	0.806597167354832	0.346681748010133	0.509317086615141	NA	NA	NA	NA	NA	0.543847598768174	0.690872707580422	0.468037974748773	0.543847598768174	NA	NA	NA	NA	NA	p.Asp58Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.861	-3.077	1.216	8.909	8.909	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D58V	58	D	V	missense	low	0.328064104737993	0.169874222000623	8	0.0600596071627148	0.210349437773448	0.445778771702538	0.184883384068456	0.172398397503314	0.453338502216878	0.603392075071807	0.384197503014629	0.0903696098256378	0.329658725858953	0.406274640344267	0.481679737744441	0.395075888041408	0.387696283277055	0.51639276421203	0.560315805224544	0.523641505821757	0.335882450889815	0.465139283924935	0.498220191563947	p.Asp58Val	1	0	NA	NA	NA	NA	NA	NA	NA	-1.104	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.861	-4.014	2.153	3.718	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D58W	58	D	W	missense	low	0.307019034273458	0.267495045564621	5	0.119627421105379	0.0725535973435079	0.541484471203408	NA	0.445931704526107	0.372008509226579	0.502906615978753	-0.161582154244317	NA	NA	0.375830495880167	0.482929679160872	NA	0.51379053436964	0.476504268888267	0.516247752270436	0.319772158289773	NA	NA	0.482929679160872	p.Asp58Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.861	-3.816	1.955	13.8	13.8	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D58X	58	D	X	nonsense	low	-0.0902234587857366	0.0680591666302392	4	0.0340295833151196	-0.156920216492276	-0.0235267010791971	NA	-0.0749448734229129	-0.0315323884085225	-0.0660432697369892	-0.188373303574522	NA	NA	NA	0.276130920024286	NA	0.27367519805823	0.278586641990342	0.266733903020502	0.309764650569511	NA	NA	NA	p.Asp58Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D58Y	58	D	Y	missense	low	0.53734426863239	0.0627221382339325	2	0.0443512492757337	0.450417417382594	0.624271119882186	NA	NA	NA	NA	0.581695517908123	NA	0.492993019356656	NA	0.575262270249648	NA	NA	NA	NA	0.59741448526444	NA	0.553110055234857	NA	p.Asp58Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	112.1	26.4	0.885	113.4	48.7	-70.8	-40.5	27.2727272727273	-3.8	1	0	59.19	0	0	0	0	9	25.8607980901595	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.861	-4.576	2.715	1.893	NA	35.98	0.003895124	0	0.111329129	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S59A	59	S	A	missense	possibly_wt-like	0.716470949894504	0.330169335431038	8	0.116732488011571	0.487679477566071	0.945262422222938	1.09849699696177	0.817941342018014	0.788956286015459	0.719931069203482	0.77031901001085	0.0160863775779376	0.531604824320104	0.988431693048413	0.674434913711039	0.829751792366519	0.685280716495275	0.680997332679388	0.611424160711652	0.667872494742691	0.299270274391221	0.573906118275657	0.790607440133437	p.Ser59Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.259	-2.66	0.401	24.797	24.797	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.735	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
S59C	59	S	C	missense	low	0.539855935336012	0.188632015585611	5	0.0843588019164454	0.374515721800831	0.705196148871194	NA	0.73038645856666	0.616744653879489	0.266082170894443	0.430912436285929	NA	NA	0.655153957053542	0.596535713655609	NA	0.644919388734276	0.596535713655609	0.412388026883324	0.541091300513356	NA	NA	0.623219344800112	p.Ser59Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.259	-3.662	1.403	15.47	15.47	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.67	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S59D	59	S	D	missense	wt-like	0.963486550108858	0.209306649296407	7	0.0791104773986436	0.808432863607746	1.11854023660997	NA	1.10348876839995	1.13884278228695	0.855795945522737	0.593026567757343	0.949048143271021	1.2066229306366	0.897580712887412	0.759101649500142	NA	0.816913274420092	0.852600026313432	0.6710079116173	0.601647061009777	0.759101649500142	0.937466410417613	0.744977711874152	p.Ser59Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.259	-3.95	1.691	4.649	NA	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.67	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
S59E	59	S	E	missense	wt-like	0.997730392950997	0.197467957517202	8	0.0698154659137354	0.860894594196192	1.1345661917058	1.10163441033738	1.03553516644603	1.01571317499973	1.27673646119803	0.911399199306634	0.581714085987262	1.03218709645946	1.02692354887346	0.801075353581833	0.831244499980586	0.785587807548487	0.792210807233099	0.855612023522984	0.720571282172531	0.578052724564137	0.843516422646867	0.809939899930567	p.Ser59Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.259	-2.422	0.163	15.258	15.258	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S59F	59	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser59Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.259	-4.551	2.292	4.855	NA	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.67	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S59G	59	S	G	missense	wt-like	0.915779905823813	0.0995649900831073	8	0.0352015398282683	0.846786155560055	0.984773656087571	0.808129136434688	0.949706693833195	0.91304069705454	1.05831729106409	0.996005428846885	0.754503011878624	0.966683106707435	0.879853880771047	0.743938581870091	0.691601582496236	0.746022326129314	0.741854837610867	0.759823959831687	0.752174909358161	0.663215667267574	0.808236406558613	0.736074444887552	p.Ser59Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.259	-3.411	1.152	11.133	11.133	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.465	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S59H	59	S	H	missense	possibly_wt-like	0.749068240879036	0.352987376994742	8	0.124799883973117	0.504464963016948	0.993671518741123	1.0902843563142	0.373421281851307	0.750545982161121	0.102201004053923	1.14405926464115	0.769931044126519	0.93069931659675	0.831403677287317	0.691280073675504	0.82584441078857	0.480364449834992	0.662158904575001	0.340517688590685	0.807478617551637	0.670819723022747	0.788855774953923	0.71174042432826	p.Ser59His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.259	-3.59	1.331	9.048	9.048	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.045	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S59I	59	S	I	missense	wt-like	0.825940102878969	0.126785254460476	6	0.0517598633895153	0.724492634790806	0.927387570967133	NA	0.715959784726828	0.92623971152251	0.727000977107804	0.689969497388772	NA	0.944518883812743	0.951951762715159	0.693298630822874	NA	0.638268934888672	0.748328326757076	0.614524679719281	0.637858912347471	NA	0.796298902549031	0.772285466005319	p.Ser59Ile	0	0	NA	NA	NA	NA	NA	NA	NA	-1.623	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.259	-3.332	1.073	8.894	8.894	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.21	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S59K	59	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser59Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.259	-2.421	0.162	12.65	12.65	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S59L	59	S	L	missense	wt-like	0.828132865757633	0.123647213349097	8	0.0437158915169831	0.742451292832286	0.91381443868298	0.601079723723955	0.991506989540078	0.845226971873382	0.821176017206427	0.883024479145401	0.737035553642458	0.953927794843174	0.792085396086189	0.700294161553719	0.593092333684803	0.765291558969645	0.708595429115674	0.655825288697722	0.709972250844164	0.654606434139541	0.801366479864294	0.691992893991765	p.Ser59Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.259	-2.867	0.608	20.5	20.5	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.43	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
S59M	59	S	M	missense	wt-like	0.966395553057659	0.20360150613794	8	0.071984002824966	0.825309500057696	1.10748160605762	0.655180616844824	1.06743663715715	0.941565257162089	0.961662895762346	0.698817131844271	1.26368016969511	1.08623062423284	1.05659109176264	0.778069313505632	0.618832268281044	0.800293848658632	0.755844778352631	0.717436025807719	0.641163838501559	0.914175182718747	0.872623909633982	0.824840365701604	p.Ser59Met	0	0	NA	NA	NA	NA	NA	NA	NA	-0.175	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.259	-3.101	0.842	4.662	4.662	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.865	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S59N	59	S	N	missense	wt-like	1.02002876652595	0.111042319640572	5	0.0496596350191156	0.922697670403083	1.11735986264882	1.16901213149968	1.07895737487819	0.874245240052062	0.973632313351451	NA	1.00429677284838	NA	NA	0.786332190177839	0.86330123760388	0.805604714859097	0.722827510196598	0.722685232338766	NA	0.786332190177839	NA	NA	p.Ser59Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.259	-3.136	0.877	15.797	15.797	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.775	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S59P	59	S	P	missense	low	0.216865877848976	0.12097407937705	7	0.0457239041595229	0.127248672463749	0.306483083234202	NA	0.190686617999237	0.214877355180897	0.366368074627009	-0.00258332518442461	0.195015608668819	0.21000172389936	0.343695089751931	0.399438907477056	NA	0.396126845142991	0.399438907477056	0.456368564526534	0.379164235491013	0.387459605835666	0.40069281325669	0.466789733873164	p.Ser59Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.259	-4.298	2.039	2.488	NA	85.61	0.003628359	0	0.103704554	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Dec 22, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S59Q	59	S	Q	missense	wt-like	0.995498576743103	0.316062063011936	8	0.111744814015775	0.776482765813058	1.21451438767315	1.24745063773664	0.942900906295383	1.13905205315924	1.35569011916591	0.36755893058672	1.16453151542897	0.750969961823091	0.995834489748877	0.823514072060199	0.900620437045846	0.742884972612785	0.85270266372804	0.890237271908691	0.517426369622329	0.86530751878235	0.692054731964774	0.794325480392357	p.Ser59Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.259	-2.724	0.465	8.918	8.918	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.875	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S59R	59	S	R	missense	wt-like	0.902802046847541	0.134938665404109	8	0.0477080226757539	0.809296040629443	0.996308053065639	0.756177451909006	0.765069350320959	1.00948991640503	1.05221570152066	0.755293869868896	1.07373276577024	0.939098164507434	0.8713391544781	0.744473019242466	0.666884190883716	0.660907618135236	0.789158594731584	0.757148098333607	0.662260036534371	0.820555294790911	0.79337933894649	0.731797940151325	p.Ser59Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.259	-2.817	0.558	10.671	10.671	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.735	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S59S	59	S	S	synonymous	wt-like	0.913986608173188	0.138048194111227	8	0.0488074070933028	0.818325848091529	1.00964736825485	1.10305302693998	0.968956257046504	0.947792575089852	0.85779996486696	0.765259125967094	1.08414534476173	0.862136017224955	0.722750553488421	0.753412042863325	0.831919444449371	0.75489605080899	0.758898981764044	0.671886777389317	0.665982436648974	0.825687370608113	0.751928034917659	0.657169604017019	p.Ser59=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S59T	59	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser59Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.259	-2.052	-0.207	10.801	10.801	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S59V	59	S	V	missense	wt-like	1.01280361392165	0.0705930269061158	8	0.0249584040148994	0.963886040940851	1.06172118690246	0.934080585509892	1.11341377119716	1.03077185941869	1.11758073608888	0.943251278578711	0.979248310086146	1.00682569323772	0.977256677256026	0.785404422574835	0.751526324482557	0.821488533676188	0.799596376085901	0.78581403498452	0.73246923866902	0.773986486956263	0.829856938437267	0.784994810165151	p.Ser59Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.259	-3.431	1.172	6.013	6.013	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.975	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S59W	59	S	W	missense	possibly_wt-like	0.750296934110938	0.337972891854443	8	0.119491461843752	0.516097972437142	0.984495895784735	0.505604293100403	1.10622643243197	1.04484309583597	0.836448600547514	0.410224385955129	0.225230598971789	0.766817874305823	1.10698019173891	0.681556708289602	0.547667365666109	0.818175291465176	0.80649764863485	0.662523103660161	0.533363531135085	0.402351749384117	0.700590312919044	0.850148193256933	p.Ser59Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-2.045	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.259	-5.708	3.449	1.016	NA	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S59X	59	S	X	nonsense	low	0.048052543325257	0.268072774494227	8	0.0947780383481801	-0.137708998362532	0.233814085013046	-0.079176786428668	0.0602323842512843	-0.0144375083192582	-0.0462399071632291	-0.211866341911918	0.678483950965031	-0.0462257521840959	0.0436503073929099	0.293979990044097	0.269442259352818	0.335989638872405	0.286970868023439	0.275418698198296	0.300989112064754	0.625747948225071	0.262690387561725	0.316092824930672	p.Ser59Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	2	0	3	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S59Y	59	S	Y	missense	wt-like	1.04798095193341	0.24340960062099	5	0.108856082672922	0.834626950396373	1.26133495347046	NA	1.12474530726051	1.11233036059288	1.2385499912268	0.621720635541414	1.14255846504546	NA	NA	0.838865288263862	NA	0.82671218109664	0.839596943811119	0.838865288263862	0.612365380755436	0.854477602332687	NA	NA	p.Ser59Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	-1.037	40.8	114.7	26.2	0.811	126.2	27.5	-70.9	-30.8	55.9440559440559	-4.2	1	0	61.92	1	3	0	0	7	27.605920340753	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.259	-3.65	1.391	11.735	11.735	85.61	0.003628359	0	0.103704554	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.12	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K60A	60	K	A	missense	possibly_low	0.659104271063877	0.153062045598661	7	0.0578520154024123	0.545716404442093	0.772492137685662	NA	0.456043372249245	0.84007770296904	0.580912812885694	0.659643901498131	0.537461121911896	0.666920610578125	0.872670375355011	0.626531155137183	NA	0.518451843015099	0.706069957502315	0.550457490147637	0.626531155137183	0.556241647120567	0.646786306707697	0.732466543250146	p.Lys60Ala	0	0	NA	NA	NA	NA	NA	NA	NA	-0.095	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.666	-3.591	1.925	5.036	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60C	60	K	C	missense	low	0.585319806441437	0.110582928085935	8	0.0390969691665144	0.508691154970396	0.661948457912479	0.624550944105128	0.408865513955604	0.424588474108225	0.710126977321555	0.667244265937019	0.63863175973287	0.579364441623227	0.62918607474787	0.605182640370941	0.604259389211143	0.496703644324278	0.502292242133947	0.607124561106702	0.62937017875881	0.606105891530739	0.599629132601987	0.610177026368576	p.Lys60Cys	0	0	NA	NA	NA	NA	NA	NA	NA	0.805	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.666	-5.441	3.775	1.352	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60D	60	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.666	-4.016	2.35	3.35	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60E	60	K	E	missense	possibly_wt-like	0.717377300747363	0.207649385464355	8	0.0734151442855323	0.573486262027908	0.861268339466817	1.15130925053131	0.501883849538073	0.77284214829484	0.645898335410477	0.779239618016507	0.500231891237132	0.752191966774642	0.635421346175918	0.642256679303072	0.854878622522963	0.539583531570232	0.673094114155909	0.578956991206995	0.671204679278178	0.537892376051879	0.692712895757756	0.613308679327966	p.Lys60Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.666	-3.7	2.034	3.409	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.145	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K60F	60	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.666	-3.133	1.467	11.956	11.956	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60G	60	K	G	missense	low	0.368094868840227	0.11204329333894	8	0.039613286253219	0.290454254474642	0.445735483205812	0.346915681424548	0.435048536570552	0.463162572379053	0.528065975136227	0.215261276196287	0.350947972367268	0.212942220475916	0.392414716171968	0.481713060999514	0.47216705042031	0.508773577101046	0.521211003613219	0.527281428004716	0.460537434649624	0.464314409387209	0.402276545284633	0.491259071578719	p.Lys60Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.666	-3.84	2.174	2.574	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60H	60	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.666	-2.807	1.141	17.043	17.043	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.17	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K60I	60	K	I	missense	possibly_low	0.594237437770803	0.156892727696977	7	0.0592998771429679	0.478011814282936	0.71046306125867	NA	0.720384420777295	0.756352101311428	0.763635565791491	0.344906779531807	0.518538952143876	0.535356395331586	0.520487849508138	0.575926689635392	NA	0.640308617643263	0.665006530008878	0.63059083504798	0.508964934326345	0.546915426406678	0.575926689635392	0.555583553946309	p.Lys60Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.666	-3.598	1.932	11.897	10.309	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60K	60	K	K	synonymous	wt-like	1.02984646975677	0.0616942777122945	3	0.0356192078446528	0.960034105223402	1.09965883429013	NA	1.0996861477985	1.00709209129898	NA	NA	NA	NA	0.98276117017282	0.787982575504073	NA	0.815160330319255	0.787982575504073	NA	NA	NA	NA	0.787759431037192	p.Lys60=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K60L	60	K	L	missense	low	0.494741420282587	0.168726100003672	8	0.0596536847378781	0.37782234665124	0.611660493913935	0.593257894110037	0.556872202196151	0.70197755043712	0.649951116551822	0.233902589712318	0.290271410377369	0.525692823922361	0.406005774953521	0.567827095319281	0.58937089081998	0.564932236715882	0.638338397644226	0.580734344622705	0.467500670404396	0.434408589060295	0.570721953922681	0.498085154443859	p.Lys60Leu	0	0	NA	NA	NA	NA	NA	NA	NA	-1.203	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.666	-3.135	1.469	10.157	10.157	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60M	60	K	M	missense	possibly_low	0.657090771227345	0.048426747795118	2	0.0342428817567386	0.589975956257274	0.724205586197416	0.622847889470606	NA	NA	NA	NA	NA	NA	0.691333652984084	0.622419821294268	0.603449115805703	NA	NA	NA	NA	NA	NA	0.641390526782833	p.Lys60Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.666	-3.68	2.014	6.712	6.712	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K60N	60	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.666	-2.649	0.983	12.732	12.732	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.105	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K60P	60	K	P	missense	low	0.539836000276453	0.0917897126830779	4	0.0458948563415389	0.449883734771397	0.629788265781509	NA	0.495860302458988	0.662067655667846	0.552378211334149	NA	NA	NA	0.449037831644829	0.537375187199954	NA	0.536806777740415	0.618764491483113	0.537943596659492	NA	NA	NA	0.519697921304303	p.Lys60Pro	0	0	NA	NA	NA	NA	NA	NA	NA	10.538	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.666	-4.31	2.644	1.237	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60Q	60	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.666	-2.778	1.112	7.06	7.06	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K60R	60	K	R	missense	wt-like	1.06765187334931	0.171472766253049	8	0.0606247779031732	0.948829492088348	1.18647425461027	1.17611615416239	1.0321521261538	0.999552068072172	1.11235661584423	1.32680279079053	0.767021646488106	1.18316656964174	0.944047015641497	0.784156417727635	0.866681164776241	0.784028282908848	0.784284552546423	0.783522988999779	0.87574023732119	0.669385760382471	0.924832969364584	0.768315322146768	p.Lys60Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.666	-1.993	0.327	17.672	17.672	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.36	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K60S	60	K	S	missense	possibly_low	0.704105723351398	0.296935125778133	3	0.171435574799861	0.368098171074749	1.04011327562805	NA	0.900343218707353	0.849479486817382	0.36249446452946	NA	NA	NA	NA	0.710681085541074	NA	0.723266594861817	0.710681085541074	0.45466978684822	NA	NA	NA	NA	p.Lys60Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.666	-3.341	1.675	4.748	4.748	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60T	60	K	T	missense	possibly_low	0.684313944581225	0.248532757859371	7	0.0939365528498471	0.500201684163682	0.868426204998769	0.825755135010984	0.425593642074672	0.626109756589026	NA	0.574911707642326	0.384672414004204	0.914562097489083	1.03859285925828	0.60112885133952	0.69998761874029	0.50441502986015	0.60112885133952	NA	0.594880475514764	0.480936265654997	0.780164375362944	0.815800788397473	p.Lys60Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.666	-3.243	1.577	7.078	7.078	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K60V	60	K	V	missense	possibly_low	0.592860602640767	0.172477300871367	6	0.0704135632245571	0.454852554697501	0.730868650584033	0.384828632508801	0.630034834865793	0.520315935587441	0.759139832488487	0.446763898514126	NA	NA	0.816080481879955	0.573950495205616	0.49020514230687	0.598658979081745	0.549242011329487	0.628619224279094	0.547012421278686	NA	NA	0.704044379208408	p.Lys60Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.666	-3.11	1.444	19.507	19.507	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.145	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60W	60	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.666	-5.515	3.849	1.085	NA	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K60X	60	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys60Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K60Y	60	K	Y	missense	wt-like	1.21428372107204	0.056657421000827	3	0.0327111772664174	1.15017099173796	1.27839645040612	NA	1.22393384840608	1.15342099474594	1.2654963200641	NA	NA	NA	NA	0.859749946510385	NA	0.872436429265345	0.859749946510385	0.850682642305318	NA	NA	NA	NA	p.Lys60Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.1	113.4	29.4	0.59	134.3	31.7	-105.4	-14.4	41.7391304347826	-2.7	1	0	62.12	0	0	1	42	5	26.3667517502631	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.666	-2.58	0.914	12.523	12.523	72.46	0.003734927	0	0.106750428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H61A	61	H	A	missense	low	0.379572089456969	0.134357532752622	8	0.0475025612564363	0.286468780220946	0.472675398692992	0.412418809719196	0.448640875741956	0.502175009659565	0.517090225033827	0.107448700707325	0.349785093483992	0.279417896099243	0.419600105210648	0.504122390588	0.503331900774751	0.51503941670599	0.540344749539127	0.52246799588141	0.420265359411303	0.463741258143883	0.438079904963135	0.50491288040125	p.His61Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-0.901	-3.505	2.604	2.382	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61C	61	H	C	missense	possibly_low	0.534034382644434	0.241020405193623	4	0.120510202596812	0.297838725785057	0.77023003950381	0.324577072959584	0.480363514035179	0.450074272065304	0.881122671517667	NA	NA	NA	NA	0.522227416788859	0.461538865048683	0.529663019081154	0.514791814496564	0.682114986336093	NA	NA	NA	NA	p.His61Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-0.901	-3.511	2.61	17.869	17.869	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H61D	61	H	D	missense	low	0.234913538998994	0.220204320954776	7	0.0832294101240265	0.0717868927013883	0.398040185296599	NA	0.308166905793349	0.462986862867579	0.238878770200143	0.0217841956955731	-0.0170315600305589	0.551315645825741	0.0782939526411288	0.400457933582779	NA	0.450283280674644	0.521124826450661	0.400457933582779	0.388266426305025	0.282947347395415	0.584522236506992	0.333492528442797	p.His61Asp	1	0	NA	NA	NA	NA	NA	NA	NA	10.124	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-0.901	-3.786	2.885	0.887	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	Vater association with macrocephaly and ventriculomegaly	Pathogenic(Last reviewed: Dec 1, 2001)	no assertion criteria provided	1	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	null	D	A	D	D	D	D	0.857142857142857
H61E	61	H	E	missense	low	0.361335148320685	0.201342544207151	6	0.0821977494702143	0.200230519748819	0.522439776892552	NA	0.221060674915081	0.432180718822839	0.485785212808367	0.63347747672669	0.0655966067967419	NA	0.329910199854394	0.482941088477759	NA	0.410128774199212	0.506015877248878	0.508739134522444	0.616757005671463	0.323672514247994	NA	0.459866299706641	p.His61Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-0.901	-3.537	2.636	1.499	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61F	61	H	F	missense	wt-like	0.934803029296037	0.0566582561228998	3	0.0327116594243709	0.870689354949729	0.998916703642344	NA	NA	0.878567404899004	0.991874665048533	NA	NA	NA	0.933967017940572	0.730685443790753	NA	NA	0.724947326588398	0.730685443790753	NA	NA	NA	0.763252662887261	p.His61Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-0.901	-3.125	2.224	10.808	10.808	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.585	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61G	61	H	G	missense	low	0.350122143538845	0.112751870086012	8	0.0398638059646418	0.271990519561454	0.428253767516236	0.453262561369744	0.295423756154119	0.341714724353993	0.500291697623154	0.216483973302636	0.399582434802991	0.181322164411837	0.41289583629229	0.474965807608936	0.522764398752214	0.444408903152547	0.461646607504067	0.515100975795459	0.460994158270568	0.488285007713806	0.385246192005766	0.50154567436363	p.His61Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-0.901	-3.64	2.739	1.152	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61I	61	H	I	missense	possibly_low	0.606646811456824	0.227259840337533	6	0.0927784413088881	0.42480440794964	0.788489214964008	0.382785513810097	0.761426245646132	0.815880500826367	0.491459981270136	0.84596408841304	NA	NA	0.342364538775171	0.585228010584665	0.489233074404784	0.659228208191985	0.694202380129829	0.511227812977344	0.696128792999229	NA	NA	0.466121467230392	p.His61Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-0.901	-4.122	3.221	1.801	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H61K	61	H	K	missense	low	0.135623261992128	0.209296126673544	7	0.0791065002210384	-0.0194226293841174	0.290669153368373	-0.0639817232831847	0.0769904336996958	0.43940724885885	NA	-0.113490767853263	0.229404239830824	0.0317947881960739	0.349238614495897	0.343714817637541	0.276671713600027	0.343714817637541	0.509560146699176	NA	0.337736110289547	0.404408822981334	0.304711735120051	0.469573958404562	p.His61Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-0.901	-3.029	2.128	5.844	5.844	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61L	61	H	L	missense	low	0.654594345166546	0.0493468421999376	8	0.0174467433748592	0.62039935650431	0.688789333828783	0.705269824195147	0.703170809768313	0.637496144613053	0.722081501089432	0.607447957724889	0.588549452495945	0.639703979142207	0.633035092303385	0.612238711943278	0.642663536986616	0.632373432665605	0.606713333383003	0.612367235929495	0.607033995689523	0.581421690042295	0.632127608839639	0.61211018795706	p.His61Leu	1	0	NA	NA	NA	NA	NA	NA	NA	4.025	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-0.901	-3.685	2.784	3.202	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	not provided	Uncertain significance	no assertion criteria provided	0	0	1	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.79	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H61M	61	H	M	missense	possibly_low	0.506449019599533	0.22022883646997	4	0.110114418234985	0.290628725680382	0.722269313518684	NA	0.203014292552004	0.49899214958928	NA	0.71213021495886	NA	NA	0.611659421297989	0.570079003354326	NA	0.40180969564249	0.538783707980389	NA	0.646136778647114	NA	NA	0.601374298728264	p.His61Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-0.901	-4.868	3.967	0.704	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H61N	61	H	N	missense	low	0.284073274747271	0.0703896711175253	4	0.0351948355587627	0.215092664610286	0.353053884884255	0.33885066599917	0.304415017923986	NA	NA	NA	0.180831418772534	NA	0.312195996293393	0.44976154944846	0.468329905456675	0.448553723509486	NA	NA	NA	0.380468606006247	NA	0.450969375387435	p.His61Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-0.901	-3.59	2.689	0.885	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H61P	61	H	P	missense	low	0.424473844148485	0.262821254414713	8	0.0929213456182993	0.24235135334162	0.606596334955351	0.974695835855232	0.374412498541867	0.436653069010761	0.403247695788426	0.1435706208954	0.576443385348788	0.172365277500642	0.314402370246764	0.476681781636794	0.770850106904474	0.480821384047601	0.508209352410968	0.472542179225987	0.433758263007839	0.575454940162354	0.38042207189455	0.452077522418455	p.His61Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-0.901	-4.157	3.256	0.572	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H61Q	61	H	Q	missense	low	0.314034943184889	0.180177562521314	8	0.0637023881382422	0.189180556704743	0.438889329665035	0.33749089376902	0.232617681294989	0.511238633114193	0.5356940963739	-0.0184436979459268	0.246820456417291	0.243335173678336	0.42352630877731	0.443164473414194	0.467682957758572	0.415456359641029	0.544790025980125	0.530626752330008	0.373239786304429	0.412992800499642	0.418645989069816	0.506884808513857	p.His61Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-0.901	-3.972	3.071	1.123	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	high	3.585	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H61R	61	H	R	missense	low	0.191643755363924	0.0812825276668351	8	0.0287377132526011	0.135318872390787	0.247968638337062	0.204976873853319	0.183797901016587	0.231861734732201	0.349922545729654	0.104741814489138	0.108018738710416	0.128903394865791	0.220927039514286	0.40488280892342	0.404635898662991	0.392951262548057	0.407768938249222	0.449156352482642	0.419254235013745	0.344581224519122	0.357013789064938	0.405129719183849	p.His61Arg	1	0	NA	NA	NA	NA	NA	NA	NA	6.355	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-0.901	-3.785	2.884	2.261	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic(Last reviewed: Mar 1, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	13	0	0	1	0	2	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H61S	61	H	S	missense	low	0.331022380273358	0.0981529677979145	8	0.0347023145617451	0.263007093552158	0.399037666994558	0.195132190330074	0.32389430709946	0.357226052455915	0.512023794993628	0.334150291592754	0.214049917915578	0.372398935263887	0.339303552535568	0.466919134702445	0.399952029407027	0.457533347991533	0.469254176565737	0.520246105178866	0.504946979188764	0.396841097036094	0.48815887832109	0.464584092839153	p.His61Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-0.901	-3.646	2.745	1.562	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61T	61	H	T	missense	low	0.346843271956164	0.107744592531202	4	0.0538722962656012	0.241255511511114	0.452431032401214	NA	0.391833559022427	0.270389320930867	0.477602009541712	NA	NA	NA	0.247548198329649	0.457758543754273	NA	0.488852199740374	0.426664887768173	0.505150378117847	NA	NA	NA	0.418500144473038	p.His61Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-0.901	-3.863	2.962	1.393	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61V	61	H	V	missense	low	0.415337282467547	0.0961300690719809	8	0.0339871118583644	0.348723767286618	0.481950797648475	0.468911090897718	0.400272793858864	0.514800883245712	0.572102398162232	0.368761423468387	0.366467472407175	0.278913134541785	0.352469063158502	0.505309045586223	0.530209601656304	0.492742544971371	0.546537140328581	0.546593669191994	0.517875546201076	0.471963547119077	0.437808043723304	0.471196444968482	p.His61Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-0.901	-3.871	2.97	2.038	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H61W	61	H	W	missense	low	0.533423408498423	0.169735749215059	8	0.0600106496398736	0.415804696515419	0.651042120481427	0.53178295586982	0.525831817565917	0.607430158191556	0.83399938215204	0.325038221795319	0.422585859896089	0.35381057518444	0.666908297332205	0.555372850252135	0.560122558706941	0.550623141797328	0.591967396310056	0.661448995158074	0.501543276431504	0.499622767718275	0.478147310397673	0.629122939365983	p.His61Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-0.901	-5.151	4.25	1.091	NA	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H61X	61	H	X	nonsense	low	0.0951611660305823	0.186850595765621	7	0.0706228869600131	-0.0432571488952867	0.233579480956451	0.00289397079574574	0.0935948241980659	0.00844695238278486	0.0642254157266774	0.507464073931638	0.0288755130178224	NA	-0.0393725878386583	0.30848959852522	0.30848959852522	0.351369162212721	0.29819460812396	0.323863435801545	0.569686232940328	0.305573689978041	NA	0.274394737116957	p.His61Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H61Y	61	H	Y	missense	possibly_wt-like	0.799641188395671	0.326708483064667	5	0.146108475391687	0.513273838791909	1.08600853799943	0.549874853844175	0.390485370216608	0.929632301612206	0.922014635177753	NA	NA	NA	1.20619878112761	0.700048220022186	0.568730258944742	0.488230707390315	0.74999223092026	0.700048220022186	NA	NA	NA	0.899980536992278	p.His61Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	2.12	42.2	112	31.1	0.701	70	-170.3	-146	88.2	11.1111111111111	-2.7	0	0	61.06	0	0	0	0	7	26.0296764839673	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-0.901	-2.405	1.504	12.601	12.601	19.35	0.001382074	0	0.03950198	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K62A	62	K	A	missense	possibly_wt-like	0.824727457976479	0.451411742550706	8	0.15959815213242	0.511920827797791	1.13753408815517	1.22734807428037	1.27351465569058	0.849374615677128	0.944320437528203	0.883097615835384	0.0332168496096006	0.255504847926678	1.13144256726388	0.710314610698284	0.891056109384467	0.895292347000379	0.710629651232109	0.709830464020825	0.709999570164459	0.307713416222154	0.425200495213575	0.862434373833112	p.Lys62Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.121	-2.403	0.282	10.71	10.71	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.56	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K62C	62	K	C	missense	possibly_low	0.686202104000727	0.492016590285312	5	0.220036508387124	0.254938472278018	1.11746573572344	NA	0.896104285176011	0.923618561197153	1.01418918327619	-0.180914412764859	NA	NA	0.778012903119136	0.72131251784325	NA	0.72131251784325	0.747042777125855	0.740471510150776	0.312550828439011	NA	NA	0.6849250117424	p.Lys62Cys	0	0	NA	NA	NA	NA	NA	NA	NA	0.536	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.121	-5.488	3.367	0.792	NA	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K62D	62	K	D	missense	possibly_wt-like	0.726772920803397	0.194552702244199	5	0.0870066134848608	0.556243091956273	0.897302749650521	NA	1.00330508930194	0.729165223805521	0.8085365827927	NA	0.586391281610899	NA	0.506466426505923	0.650282245255602	NA	0.770730284403049	0.651672658992912	0.650282245255602	NA	0.580357986552738	NA	0.548541321487553	p.Lys62Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.121	-3.399	1.278	14.373	14.373	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.555	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K62E	62	K	E	missense	wt-like	1.01618781590768	0.213439637948756	7	0.0806726002765819	0.858072424826388	1.17430320698898	0.86522574908639	0.845027366990424	1.03111967959504	0.939641574380376	1.37990708945289	1.2295178978616	NA	0.822875353987066	0.718766810102337	0.718766810102337	0.697766918161702	0.799766965347843	0.707778541376251	0.895576701680843	0.897337531904215	NA	0.707457090521534	p.Lys62Glu	1	0	NA	NA	NA	NA	NA	NA	NA	2.179	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.121	-2.771	0.65	9.14	9.14	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.03	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K62F	62	K	F	missense	wt-like	1.06824276933902	0.187580190268853	3	0.108299473346364	0.855979702035495	1.28050583664255	NA	NA	NA	NA	0.901720986486176	1.27145865089896	1.03154867063194	NA	0.843172570714315	NA	NA	NA	NA	0.716956103580328	0.918008983673675	0.843172570714315	NA	p.Lys62Phe	0	0	NA	NA	NA	NA	NA	NA	NA	1.668	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.121	-3.973	1.852	7.939	7.939	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K62G	62	K	G	missense	wt-like	0.967625416053046	0.115561122006051	8	0.0408570265060024	0.887547115585883	1.04770371652021	0.933475409991519	1.01466044556924	1.01919243539889	1.01242940670984	1.0060144062213	1.09267905685069	0.956058153916669	0.706494013766217	0.765939276779969	0.751238396181127	0.775964912536638	0.793917219062971	0.739699757425423	0.755913641023301	0.829893404240943	0.802513877185757	0.649004788528558	p.Lys62Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.121	-2.27	0.149	25.43	25.43	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.15	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K62H	62	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys62His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.121	-3.859	1.738	10.454	10.454	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K62I	62	K	I	missense	possibly_wt-like	0.792470078801592	0.203584355002287	7	0.0769476534513629	0.641655449342051	0.943284708261132	NA	0.695859726985672	0.611056454039953	0.82735876348257	1.12360039307335	1.00734936040051	0.683051025713613	0.599014827915471	0.655474041724214	NA	0.629003146545106	0.593745922038057	0.658536741606013	0.799836455110633	0.787836727216068	0.655474041724214	0.595023576270774	p.Lys62Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.121	-4.4	2.279	4.483	NA	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K62K	62	K	K	synonymous	wt-like	1.00992495502346	0.178666893186458	8	0.0631682858728383	0.886117389747567	1.13373252029935	0.59355876961177	1.16420252605138	1.05106993155888	1.11462059459001	1.10199006906146	1.06103318060828	1.02952308276266	0.963401485943235	0.800657898586382	0.589514040318804	0.844901294911641	0.809551615547709	0.784515860368	0.791764181625056	0.814296016090462	0.84208160247121	0.778036067249415	p.Lys62=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K62L	62	K	L	missense	wt-like	0.896636059253147	0.161359741508199	8	0.0570492837154779	0.784821517827003	1.00845060067929	0.714680322153915	0.871626536569995	0.999268156844992	1.13470657118534	0.626728333489143	0.95565745929254	0.90354990666433	0.966871187824915	0.768296241505064	0.647140830946174	0.71002868768559	0.784145307585968	0.793324596360522	0.61423594536821	0.762359200866619	0.774233282143508	0.779778718277739	p.Lys62Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.121	-3.131	1.01	14.629	14.629	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.615	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K62M	62	K	M	missense	wt-like	0.873314915646007	0.165907791006615	6	0.0677315720530865	0.740563473805678	1.00606635748634	0.915388553863209	0.848447922876153	0.842906497155845	1.08806849940983	0.956771305722936	NA	NA	0.588306714848071	0.722488413407258	0.742633094735285	0.699343736858575	0.707457346576672	0.772871398104467	0.737519480237844	NA	NA	0.589645447288904	p.Lys62Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.121	-4.171	2.05	3.698	3.698	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K62N	62	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys62Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.121	-3.328	1.207	12.339	12.339	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.415	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K62P	62	K	P	missense	possibly_wt-like	0.836133118756446	0.657142263889903	3	0.379401262952716	0.0925203076801128	1.57974592983278	NA	NA	NA	NA	0.0840233470449281	1.29927487768951	NA	1.1251011315349	0.859249400059856	NA	NA	NA	NA	0.411515103693009	0.931718842197127	NA	0.859249400059856	p.Lys62Pro	0	0	NA	NA	NA	NA	NA	NA	NA	-0.537	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.121	-2.213	0.092	20.624	20.624	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.795	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K62Q	62	K	Q	missense	wt-like	0.871628717307434	0.217927500876813	7	0.0823688530231227	0.710188731934241	1.03306870268063	NA	0.908657717246003	0.880226192232789	0.663423012457644	1.22551418684093	0.645683600010337	0.711080723266912	1.06681558909742	0.725760882920743	NA	0.727099438758791	0.725760882920743	0.586642465335177	0.837905112239143	0.609581551017628	0.670570651631075	0.829975599621448	p.Lys62Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.121	-2.677	0.556	10.298	10.298	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.65	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K62R	62	K	R	missense	wt-like	0.891744352191454	0.144273864761394	8	0.0510085140603864	0.791769501728191	0.991719202654716	1.05431812957687	0.992930435792818	0.840906821306868	0.645895527051812	0.985199604099951	0.724398743486838	0.902925277497972	0.9873802787185	0.757043134396364	0.80873252463497	0.765947743736186	0.70647660063267	0.578955759596974	0.748138525056542	0.648378095525329	0.773896861001503	0.790079369329173	p.Lys62Arg	1	0	no	NA	NA	NA	NA	NA	NA	2.181	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.121	-2.751	0.63	30.904	30.904	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.685	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K62S	62	K	S	missense	wt-like	0.909640872584478	0.131178366474967	8	0.0463785562397115	0.818740572699678	1.00054117246928	1.16250261737629	0.833664138227421	0.995690319119283	0.880540719435144	0.840559246939685	0.895559622191662	0.719915468766756	0.948694848619581	0.713424249244579	0.860204163634786	0.692528660940086	0.78239054826356	0.681859770353394	0.694109880256639	0.732738618232518	0.67532898718514	0.770649687229111	p.Lys62Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.121	-2.547	0.426	7.749	7.749	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.76	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K62T	62	K	T	missense	possibly_wt-like	0.717651838705001	0.301038875739069	4	0.150519437869534	0.422639161507499	1.0126645159025	1.05673351690717	0.324964617249444	NA	NA	0.769522504121321	NA	NA	0.719386716542068	0.661527546554896	0.809881709210678	0.458026742957828	NA	NA	0.667574969663029	NA	NA	0.655480123446764	p.Lys62Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.121	-3.13	1.009	9.763	9.763	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K62V	62	K	V	missense	possibly_low	0.664143043032682	0.146336348301431	8	0.0517377121090092	0.562738990656522	0.765547095408841	0.723739491821411	0.625391790210867	0.528112245406258	0.584448190812326	0.789527287481986	0.465519043048091	0.918357878583819	0.678048416896694	0.615618328203916	0.651450971154334	0.596518613636219	0.553065730677251	0.55200793558611	0.675047512981591	0.520783361187957	0.782208757981419	0.634718042771612	p.Lys62Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.121	-4.022	1.901	3.733	NA	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K62W	62	K	W	missense	possibly_low	0.626122217534878	0.23178129988712	8	0.0819470644512078	0.465508922571728	0.786735512498028	0.76745845450501	0.602619402317612	0.782487124543474	0.341912792657617	0.387595225696124	0.689993099089415	0.424960422646036	1.01195121882374	0.608720709543614	0.672251427028088	0.586020926066673	0.677824516506212	0.445643662928216	0.52491068377106	0.631420493020555	0.516468148145491	0.802420076254847	p.Lys62Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.121	-5.775	3.654	0.75	NA	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K62X	62	K	X	nonsense	low	-0.0160266457318655	0.0464482048196661	8	0.0164219203009638	-0.0482130180787417	0.0161597266150107	-0.00289397079574574	0.0421264267612137	-0.0168872861115152	0	-0.119477645909722	0.00771959037690295	-0.0185472172684622	-0.0202530629075953	0.295421897113453	0.305735831823457	0.327643097184762	0.285769368473054	0.295697280749979	0.335499784866108	0.295146513476928	0.277597863592111	0.283997481363689	p.Lys62Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	1	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K62Y	62	K	Y	missense	possibly_wt-like	0.977297179154475	0.195500637419775	2	0.138239826445815	0.70635209809161	1.24824226021734	NA	0.83905735270866	1.11553700560029	NA	NA	NA	NA	NA	0.768092246400675	NA	0.695014842050516	0.841169650750835	NA	NA	NA	NA	NA	p.Lys62Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	113.9	30.3	0.919	78.4	-21.8	-40.3	-90.3	64.3478260869565	-0.8	0	0	66.87	0	0	0	0	5	28.6342857054266	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.121	-3.544	1.423	8.663	8.663	89.83	0.003753428	0	0.107279231	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N63A	63	N	A	missense	wt-like	0.885368442787971	0.182815062395174	8	0.0646348851613346	0.758686395726872	1.01205048984907	1.06375957574437	0.678085870549185	0.665112621897005	0.89782069127698	0.893724100032317	1.20431259877146	0.887985121693869	0.792146962338578	0.702996389754514	0.813224543025544	0.62080969785405	0.62025790266793	0.689437928636637	0.713968963986626	0.88491452833982	0.765850191796693	0.692023815522402	p.Asn63Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.915	-2.928	1.013	10.35	10.35	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.68	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N63C	63	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.915	-5.477	3.562	1.488	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N63D	63	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.915	-1.797	-0.118	34.159	34.159	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N63E	63	N	E	missense	wt-like	0.886640771312899	0.135220279781348	8	0.0478075883936667	0.792939619873598	0.980341922752201	0.744867269651118	0.921394729082515	1.00040771328572	1.06810209293516	0.683423824201392	0.994992522330372	0.8813165639854	0.798621455031518	0.747614768765975	0.66150307174139	0.732970986857131	0.784704205848292	0.764115099772646	0.635413855804743	0.781746379196746	0.762258550674818	0.695275616897269	p.Asn63Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.915	-2.611	0.696	14.816	14.816	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.875	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N63F	63	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.915	-4.66	2.745	3.65	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.375	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N63G	63	N	G	missense	wt-like	0.85815141668301	0.0948663291850401	8	0.0335403123365086	0.792413612473229	0.923889220892791	0.72028198742847	0.922313983984626	0.806932942760024	0.92323327518435	0.7469248793593	0.854683791125246	0.893465992597928	0.997374481024137	0.706587346947378	0.649805971750319	0.73339474789635	0.689814028244307	0.700582656475255	0.65913390200004	0.712592037419502	0.768802152652892	0.7950989380181	p.Asn63Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.915	-1.871	-0.044	27.96	27.96	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.165	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N63H	63	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.915	-3.901	1.986	9.663	9.663	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.025	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N63I	63	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.915	-4.435	2.52	2.457	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N63K	63	N	K	missense	possibly_low	0.682068800841588	0.245709465453377	6	0.100310469222131	0.485463893893898	0.878673707789279	0.545191803381848	0.316036903120579	NA	NA	0.98303639970801	0.852512588521947	0.577355076284931	0.818280034032215	0.651848000854979	0.566502173498133	0.453911216993913	NA	NA	0.747330486387278	0.711521910951915	0.598546901706883	0.705149100003075	p.Asn63Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.915	-2.81	0.895	10.038	10.038	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	low	1.435	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
N63L	63	N	L	missense	possibly_low	0.596241998556566	0.175906697793819	7	0.0664864823304341	0.465930887730156	0.726553109382975	0.803700479611365	0.402173201912811	0.722742575520424	0.735062366346182	0.484211225587434	NA	0.365861587985705	0.659942552932039	0.618060014394038	0.689494531569612	0.493618601101211	0.648522655326775	0.618060014394038	0.561000414483845	NA	0.484637906270045	0.625624407775681	p.Asn63Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.915	-4.007	2.092	4.063	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N63M	63	N	M	missense	possibly_wt-like	0.740937081139077	0.0801535578546331	8	0.0283385621476197	0.685394519956092	0.796479642322062	0.680289362923088	0.73602588917312	0.831252215133804	0.883826120643591	0.669274227489792	0.76241839961719	0.692202915182126	0.672207518949905	0.653961130129561	0.63077842008309	0.647519071334724	0.701741475262218	0.68330058811684	0.630128446187386	0.667116945714544	0.660403188924398	0.631784463126903	p.Asn63Met	0	0	NA	NA	NA	NA	NA	NA	NA	1.192	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.915	-4.053	2.138	3.336	3.336	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N63P	63	N	P	missense	low	0.507785135340263	0.228719457124919	8	0.0808645395611679	0.34929355017396	0.666276720506567	0.43979363020934	0.351734992477621	0.493298290469569	0.603910650670595	0.261704564318673	0.397934091529033	0.501050035083141	1.01285482796413	0.526173669163448	0.516356197571957	0.470367435404409	0.535991140754939	0.560543227352624	0.477885759602415	0.487472584330354	0.557449510671538	0.802873912189868	p.Asn63Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.915	-4.238	2.323	2.377	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.375	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N63Q	63	N	Q	missense	possibly_wt-like	0.750075743915782	0.284818091075912	8	0.100698401802192	0.552710503082741	0.947440984748822	0.949376638630722	0.902050912942187	0.912889658241892	0.937646210486365	0.631887998085795	0.11742385552275	0.656523444634562	0.892807232781981	0.7154786423148	0.758803827388677	0.724053813164335	0.741780760253296	0.706903471465264	0.616163275272894	0.349216749742026	0.641186461825732	0.742580240766236	p.Asn63Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.915	-3.096	1.181	9.396	9.396	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.435	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N63R	63	N	R	missense	low	0.619065623090948	0.0857998618393622	8	0.030334832065741	0.559610444765025	0.678520801416871	0.762110140902614	0.586093679206944	0.672531624337815	0.654146779629646	0.633218399921135	0.558366897382626	0.470760910545377	0.61529655280143	0.592887700045331	0.669706825000571	0.578402845833287	0.623896570683093	0.582574359131868	0.616660230684329	0.566545532913017	0.541135988319131	0.603201040958795	p.Asn63Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.915	-3.56	1.645	12.208	12.208	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.745	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N63S	63	N	S	missense	wt-like	1.32262796455206	0.0584091822182153	2	0.0413015288300608	1.2416784555387	1.40357747356542	1.281326435722	1.36392949338212	NA	NA	NA	NA	NA	NA	0.926854905909621	0.916737746284909	0.936972065534334	NA	NA	NA	NA	NA	NA	p.Asn63Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.915	-2.613	0.698	17.954	17.954	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
N63T	63	N	T	missense	possibly_low	0.634364790746779	0.154744041718071	8	0.0547102806235311	0.527134611140579	0.74159497035298	0.930608870479272	0.66735152315558	0.528755449388406	0.614463681852673	0.667585879657229	0.52830827810548	0.416763022606836	0.721081620728759	0.590516309900929	0.749874563990816	0.615861344359931	0.553381191654079	0.565171275441926	0.629497784405743	0.5517304603727	0.512053082645516	0.656331385781272	p.Asn63Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.915	-3.219	1.304	6.705	6.163	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.025	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N63V	63	N	V	missense	low	0.388670826433718	0.0842079002173396	8	0.0297719886365805	0.330318800957885	0.447022851909552	0.347676666117163	0.347916957224427	0.431494020918893	0.534158518929543	0.250336425600856	0.351294455945598	0.409628928579267	0.436860638154	0.48965920716634	0.472529109068268	0.468607385408536	0.505679084571007	0.529953322475143	0.473639329761672	0.464485181680495	0.508210706738025	0.51358194953424	p.Asn63Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.915	-4.08	2.165	3.365	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N63W	63	N	W	missense	low	0.539060220900206	0.185345190626701	5	0.0828888891087919	0.37660098352844	0.701519458271973	0.542601339273911	0.384143958264567	0.514027927982522	0.847733169962891	NA	NA	NA	0.40679470901714	0.546158042516475	0.565269691502628	0.48530742320359	0.546158042516475	0.667471968969127	NA	NA	NA	0.498481395044385	p.Asn63Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.915	-5.767	3.852	0.764	NA	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N63X	63	N	X	nonsense	low	0.155406931296872	0.427080310959402	7	0.161421184664387	-0.160972776987116	0.471786639580861	0.0327890230869631	0.00221256044657434	-0.0173651376014937	-0.0417258429959091	1.12246068135292	NA	0.0079446237438002	-0.0184673889547439	0.291866194126759	0.32271296243546	0.30924347654648	0.285535005033164	0.27739834799598	0.799410729670469	NA	0.291866194126759	0.284894332636883	p.Asn63Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N63Y	63	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn63Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.3	111.8	31.7	0.44	116.8	92.3	-126.8	55.8	51.8716577540107	-0.4	0	0	60.77	1	19	0	0	4	28.2724544010597	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.915	-3.824	1.909	8.821	8.821	58.31	0.003916733	0	0.111946748	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.375	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H64A	64	H	A	missense	wt-like	0.899518224631738	0.197574841573519	8	0.0698532551342466	0.762608360365728	1.03642808889775	0.662001240424315	0.889745128655161	0.800179313741708	0.663085602813353	1.22601806291168	0.868149963831596	1.07458248880888	1.01238399586721	0.718805099947001	0.622077360824146	0.718381053708938	0.686501694262579	0.586494493815655	0.838093329012001	0.719229146185063	0.866350300855168	0.802637437684031	p.His64Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.718	-2.845	1.127	8.985	8.985	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H64C	64	H	C	missense	possibly_wt-like	0.780938620034114	0.322959058034435	8	0.114183269990884	0.557143523214968	1.00473371685326	0.64780036746282	1.08814398330841	1.13159999182329	1.23092593388614	0.527843730228602	0.513805999705688	0.717810748380063	0.389578205477905	0.644758158806374	0.615320918921758	0.80983958673886	0.849047781896355	0.835521746166867	0.57729880548115	0.544582683406905	0.67419539869099	0.489834439594063	p.His64Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.718	-3.79	2.072	16.19	16.19	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.05	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H64D	64	H	D	missense	possibly_wt-like	0.898870832307661	0.196533670533917	4	0.0982668352669583	0.706271374309692	1.09147029030563	NA	0.625459876580216	0.889449751130126	1.01751446695494	NA	NA	NA	1.06305923456536	0.736107209263236	NA	0.596550000306625	0.730284600093432	0.74192981843304	NA	NA	NA	0.828088977856445	p.His64Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.718	-2.979	1.261	11.518	11.518	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H64E	64	H	E	missense	wt-like	0.855557198322475	0.195698782957669	8	0.069189968249661	0.719947352461669	0.99116704418328	0.864465265408074	0.829443251441171	0.799009752496919	1.01764818154556	1.06861683023163	0.934113069090727	0.426722847092261	0.904438389273455	0.730196724499029	0.718404989825218	0.690582903167288	0.685928080070221	0.741988459172839	0.779298014491899	0.751740559313797	0.517417378307692	0.748421966514342	p.His64Glu	0	0	NA	0.614779607594464	-0.514708533853689	0.473161041669512	0.756398173519417	NA	NA	4.959	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.718	-3.699	1.981	4.895	NA	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H64F	64	H	F	missense	possibly_low	0.690330768764498	0.397888326584427	7	0.150387651674006	0.395576387763891	0.985085149765105	1.08551966961973	0.75222344856159	1.00404917491026	0.903583707675822	0.0733050474923475	0.192242475890045	NA	0.821391857201686	0.691965308360348	0.823577484739622	0.654985873615028	0.786490169668546	0.691965308360348	0.407511413362351	0.38609280442331	NA	0.706712007143562	p.His64Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.718	-3.52	1.802	13.582	13.582	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H64G	64	H	G	missense	wt-like	0.796733037549324	0.100352080241592	8	0.0354798182225032	0.727193871655189	0.866272203443458	0.829091369220175	0.728273824340233	0.820637063929536	0.825865931419271	0.929544966474968	0.887755401352596	0.611422256124463	0.741273487533347	0.681503979933207	0.701574920638439	0.643945499910595	0.696535248216029	0.657882057803891	0.727349412621099	0.728892130914342	0.616895259682788	0.666472711650386	p.His64Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.718	-2.991	1.273	13.158	13.158	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H64I	64	H	I	missense	low	0.447963788836848	0.255904972022932	4	0.127952486011466	0.197181524522009	0.698746053151687	NA	0.0857114646192006	0.453856179256656	0.655336188351317	NA	NA	NA	0.596951323120218	0.549871318175382	NA	0.347735066120329	0.516646660190884	0.583095976159881	NA	NA	NA	0.593987184996818	p.His64Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.718	-4.338	2.62	2.513	NA	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H64K	64	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His64Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.718	-2.04	0.322	10.313	10.313	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.16	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
H64L	64	H	L	missense	wt-like	0.796112598223054	0.0950357668003055	8	0.0336002175798797	0.73025738189378	0.861967814552328	0.575667643078177	0.817660098674722	0.799691414180152	0.862088646343711	0.842936520140924	0.877287463959316	0.774268754866284	0.819300244541145	0.690630142222566	0.581001862418175	0.685151068047219	0.686262402721241	0.67376758526069	0.69499788172389	0.723732770452737	0.704603307960107	0.705661498748881	p.His64Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.718	-3.412	1.694	8.2	8.2	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H64M	64	H	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His64Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.718	-4.016	2.298	3.818	3.818	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H64N	64	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His64Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.718	-2.511	0.793	15.797	15.797	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.31	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
H64P	64	H	P	missense	low	0.23277005980004	0.102723293326907	7	0.0388257554280766	0.15667297748845	0.308867142111631	NA	0.318691059618637	0.217986413586896	0.399611064049033	0.23330856453586	0.1051092918124	0.125219770021348	0.22946425497611	0.409417519061446	NA	0.455134738471234	0.400963752827821	0.470947328771875	0.46727877953043	0.343147237600133	0.355029813061842	0.409417519061446	p.His64Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.718	-3.636	1.918	10.435	10.435	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.05	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H64Q	64	H	Q	missense	wt-like	0.800624358529984	0.0765056245924787	4	0.0382528122962393	0.725650224121984	0.875598492937985	0.772667018389574	0.826852108517709	0.7117998891856	0.891178418027056	NA	NA	NA	NA	0.680627244443556	0.674729539421344	0.689388429887364	0.643155787869304	0.686524949465768	NA	NA	NA	NA	p.His64Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.718	-3.243	1.525	10.139	10.139	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.705	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H64R	64	H	R	missense	wt-like	0.930133751968355	0.13344324987243	8	0.047179313444183	0.83766399680243	1.02260350713428	1.10072779267005	0.771103689637316	0.806801054157362	0.914212147364344	1.10236136873293	0.790799272046318	1.00225748098772	0.952807210150795	0.734670769892037	0.830813152582888	0.663689347004806	0.689749343154378	0.69662642696637	0.791902876097734	0.681105102652767	0.827396529502106	0.772715112817704	p.His64Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.718	-2.887	1.169	17.159	17.159	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.055	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
H64S	64	H	S	missense	wt-like	0.90626358225332	0.146377928436587	8	0.0517524129067751	0.804830716842995	1.00769644766365	1.00612891718048	0.885573086361738	0.88036410469309	0.865003268930876	0.87079710242517	0.616706350430006	1.0232544100145	1.1022814179907	0.721143167425893	0.785805228914429	0.716457812425302	0.725828522426484	0.675045797488327	0.705404863106591	0.595299456068646	0.838705336746872	0.847788243271773	p.His64Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.718	-2.601	0.883	9.168	9.168	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.45	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
H64T	64	H	T	missense	wt-like	0.891909984653046	0.143661114379954	7	0.0542987973885377	0.785486297367675	0.998333671938418	NA	0.962060059008798	0.934053119116302	1.11515846738516	0.9521450704424	0.705004420955024	0.84629013127884	0.728658624384797	0.743393545442622	NA	0.751717019573579	0.752160431750676	0.784751745311287	0.735791406361091	0.638819163608666	0.743393545442622	0.660136921145139	p.His64Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.718	-3.903	2.185	3.424	NA	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H64V	64	H	V	missense	wt-like	0.8188514322146	0.154412469800115	8	0.0545930522477121	0.711851016002971	0.925851848426229	0.940578847586546	0.586864044363284	0.788575496988756	0.635193597131654	0.795949681349373	1.0277404155965	0.817561811005122	0.958347563695562	0.704365617859017	0.754618044992025	0.578757971205454	0.680810573763612	0.574262411736604	0.677446520034938	0.797886921442116	0.727920661954422	0.775497744620466	p.His64Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.718	-4.031	2.313	2.181	NA	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.6	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H64W	64	H	W	missense	possibly_low	0.625093329362714	0.215028575808863	4	0.107514287904431	0.414369197246558	0.835817461478869	NA	NA	NA	NA	0.929511522866344	0.423351234584911	0.579686775470416	0.567823784529184	0.589580337408834	NA	NA	NA	NA	0.727336920168185	0.5	0.599802739482388	0.579357935335281	p.His64Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.718	-5.628	3.91	0.9	NA	43.18	0.003572995	0	0.102122148	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H64X	64	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His64Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H64Y	64	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His64Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	109.7	34.2	0.009	62.7	94.9	-137.4	27.1	30.0925925925926	-2.6	0	0	56.8	1	1	0	0	7	26.3375841310474	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.718	-3.252	1.534	10.396	10.396	43.18	0.003572995	0	0.102122148	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Dec 24, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y65A	65	Y	A	missense	low	0.543789290988961	0.137248123783994	8	0.0485245395163964	0.448682941170433	0.638895640807488	0.729827768855778	0.496886357263531	0.475078290426996	0.610237196043934	0.460808904750673	0.301900434646808	0.6000700152982	0.675505360625764	0.557788252986909	0.654347630407598	0.537279771737259	0.527055096870319	0.563317743576615	0.552258762397203	0.440140217533857	0.610781017779287	0.633440797700784	p.Tyr65Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.055	-3.514	2.459	2.304	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65C	65	Y	C	missense	possibly_wt-like	0.81892066438662	0.180196603320055	4	0.0900983016600277	0.64233123806474	0.995510090708499	NA	0.970417139583204	0.613207116061714	0.722187656884295	NA	NA	NA	0.969870745017267	0.68399164189467	NA	0.7555694930724	0.594800719522279	0.61241379071694	NA	NA	NA	0.781285240049354	p.Tyr65Cys	1	0	NA	NA	NA	NA	NA	NA	NA	9.078	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.055	-3.655	2.6	16.19	16.19	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y65D	65	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr65Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.055	-4.211	3.156	1.033	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y65E	65	Y	E	missense	low	0.248395236724787	0.242248073625291	8	0.0856476277949107	0.0805289708854708	0.416261502564104	0.0623669284441875	0.0953322465235515	0.232814085943561	0.406891702994373	0.0880327903716766	0.777213051099023	0.222195945622715	0.102315142799213	0.407748280877072	0.336785435281479	0.352170084664718	0.408236021245841	0.474140264202323	0.41301278244325	0.674408825387764	0.407260540508302	0.345557124525696	p.Tyr65Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.055	-4.025	2.97	1.089	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65F	65	Y	F	missense	possibly_low	0.648680753111205	0.300039755763947	7	0.113404368169137	0.426412275810175	0.870949230412235	0.789925891293063	0.602898632233224	0.783120219169803	1.05622555861275	0.297985060942096	NA	0.213903605722335	0.796706303805167	0.678135019324586	0.682940905890806	0.586149646358454	0.678135019324586	0.758906627341358	0.491437897496122	NA	0.402794341026374	0.69431373591504	p.Tyr65Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.055	-1.935	0.88	13.964	13.964	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.005	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y65G	65	Y	G	missense	low	0.221039234805451	0.141721561537553	8	0.0501061386017752	0.122833007741599	0.319245461869302	0.1716966759133	0.315308200624719	0.330505591113744	0.437192439903199	-0.00376331570067246	0.190435432367113	0.0845161345682231	0.24242271965398	0.402363922353647	0.38880196194013	0.453575297407063	0.456149060505748	0.487428699073383	0.378723464396961	0.385202162021245	0.333107103940259	0.415925882767165	p.Tyr65Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.055	-3.86	2.805	1.413	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65H	65	Y	H	missense	low	0.565778114803962	0.0105812642767165	2	0.00748208372359321	0.551113500176406	0.580442729431519	NA	0.573260198527556	NA	NA	NA	NA	NA	0.558296031080369	0.573529733450137	NA	0.572486827221909	NA	NA	NA	NA	NA	0.574572639678366	p.Tyr65His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.055	-4.372	3.317	0.619	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y65I	65	Y	I	missense	possibly_wt-like	0.724610627412328	0.230757924789587	7	0.087218297435799	0.55366590564526	0.895555349179396	NA	0.871866619382202	0.860499683793257	0.891247329022303	0.32701291495239	0.797147887646336	0.461683194342443	0.862816762747363	0.686555170488939	NA	0.71013936182153	0.716085968283307	0.686555170488939	0.502280899023613	0.68423416190122	0.536246790349717	0.727517585463863	p.Tyr65Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.055	-3.695	2.64	4.645	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65K	65	Y	K	missense	low	0.0752019526279617	0.146290142317475	8	0.0517213758267157	-0.0261700812232616	0.176573986479185	0.112449792807485	0.143207820258991	0.177552552665612	0.129260281946488	-0.241025513249715	0.0314810134169186	0.0155925596958207	0.233097113482093	0.356499131378585	0.360613686142765	0.374239918431964	0.381132866177275	0.352384576614406	0.290097058548018	0.306857869968496	0.29598532189975	0.411242115187308	p.Tyr65Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.055	-4.029	2.974	1.143	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65L	65	Y	L	missense	low	0.610399592578954	0.115799429345599	8	0.0409412808739028	0.530156156585166	0.690643028572742	0.381113204114229	0.60181346969845	0.71933274253384	0.750257403099428	0.564046286792297	0.639159226031639	0.555445170774587	0.672029237587161	0.598593847539275	0.488437428719228	0.58564940469273	0.646850294342355	0.624723821180864	0.590821829814261	0.606365865264289	0.586746371360207	0.631694921658872	p.Tyr65Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.055	-2.903	1.848	12.02	12.02	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65M	65	Y	M	missense	possibly_low	0.624354778420474	0.173757457174584	5	0.0777066971679755	0.472052450613681	0.776657106227266	NA	0.565364096279591	0.441995681683633	0.591572830545168	0.912057816890303	0.610783466703675	NA	NA	0.568846856973515	NA	0.568846856973515	0.510829649951679	0.555132457321489	0.720817300753968	0.59238022843399	NA	NA	p.Tyr65Met	0	0	NA	NA	NA	NA	NA	NA	NA	9.878	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.055	-4.665	3.61	1.595	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65N	65	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr65Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.055	-4.262	3.207	1.16	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y65P	65	Y	P	missense	low	0.221041733922451	0.135195846016935	8	0.0477989497534134	0.127357513906922	0.314725953937981	0.196318937056516	0.238076210169646	0.327088571445214	0.452024142146629	-0.0171885101064852	0.219185281053646	0.147217286690272	0.205611952924174	0.399944416456649	0.400516655633301	0.417972649587613	0.454473174795471	0.493933164950956	0.37370864644323	0.399372177279996	0.366877530199672	0.397437746701705	p.Tyr65Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.055	-4.422	3.367	0.614	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65Q	65	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr65Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.055	-4.327	3.272	0.698	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65R	65	Y	R	missense	low	0.175113017052149	0.0698662024065077	8	0.0247014327486967	0.126699098498165	0.223526935606132	0.0988739010128777	0.187657027510472	0.135077454766926	0.238766580749099	0.230770181001945	0.0739189736172314	0.270559323156201	0.165280694602436	0.385955852744487	0.354154595604312	0.394730254914342	0.360300849824953	0.400408732726117	0.466330597259503	0.327774381569838	0.433308736105595	0.377181450574633	p.Tyr65Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.055	-4.31	3.255	0.835	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65S	65	Y	S	missense	low	0.262513795499101	0.138071791699915	8	0.0488157501007933	0.166836683423238	0.358190907574963	0.300869630094335	0.26111597511216	0.359163520976137	0.486838391012743	0.156161291331437	0.0158378628324432	0.251724427747057	0.268399264886494	0.433716953413838	0.450259420411192	0.428593593477029	0.470204412772177	0.509201007447139	0.438461354690802	0.299147788260109	0.42316438588249	0.428972552136875	p.Tyr65Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.055	-3.228	2.173	4.639	4.639	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y65T	65	Y	T	missense	possibly_low	0.564533408346982	0.25418211535196	7	0.096071809277374	0.376236122233728	0.752830694460236	0.494248084967742	0.416681701206078	0.464250577722789	0.591389989134148	1.1057453145805	0.325690095013454	NA	0.553728095804171	0.542264348493307	0.542264348493307	0.500306775103763	0.521744618513087	0.55505227193889	0.793166907878418	0.451865491432561	NA	0.57227840306155	p.Tyr65Thr	0	0	NA	NA	NA	NA	NA	NA	NA	10.399	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.055	-3.861	2.806	1.732	NA	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65V	65	Y	V	missense	possibly_wt-like	0.723245065247719	0.136744278141585	8	0.0483464031811871	0.628487856230539	0.818002274264898	0.446162319983313	0.793653387550522	0.836072094685193	0.623759225563485	0.67653392973692	0.788882758878236	0.76128362055137	0.859613185032713	0.677122441946775	0.519386270622315	0.674084378241323	0.704105397056354	0.569247850462655	0.63284021959395	0.680160505652226	0.697609600412329	0.725908594781342	p.Tyr65Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.055	-2.572	1.517	7.616	7.616	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y65W	65	Y	W	missense	wt-like	1.02931237019838	0.0689695943636689	8	0.0243844339351179	0.981519757902154	1.07710498249461	0.924820846143885	1.03259932136662	1.02708451105104	1.04739765045484	1.17356378120867	1.00584769186175	1.01655587534434	1.00662928415589	0.792442251401704	0.747120757921451	0.784234432375859	0.797787906999503	0.75503513461308	0.818499670575264	0.787096595803904	0.835097550231492	0.799747144908622	p.Tyr65Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.055	-3.522	2.467	12.198	12.198	24.57	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y65X	65	Y	X	nonsense	low	0.0468668072809475	0.147365669537173	6	0.0601617826616134	-0.071048119981541	0.164781734543436	NA	0.091191445793212	-0.0244896053840643	-0.0602265898445179	0.316934008988722	-0.0838791416981843	NA	0.0416707258305171	0.298569688101866	NA	0.350261245215882	0.282040792266377	0.26928481695205	0.498516046385153	0.25	NA	0.315098583937356	p.Tyr65Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	2	0	0	0	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Y65Y	65	Y	Y	synonymous	wt-like	1.01493714932971	0.229172820591207	7	0.0866191843627936	0.845166667608398	1.18470763105102	1.01021138578624	0.728895009864816	0.700149043651791	NA	1.3233432434582	1.13577842369636	1.16990389166169	1.03627904718887	0.81463868078143	0.787747571616031	0.644231855983149	0.637441601988965	NA	0.874447965526122	0.851135905114753	0.917689778632523	0.81463868078143	p.Tyr65=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	106.6	32.4	0.969	42.9	-172.5	-130.7	144.4	1.17647058823529	-1.2	0	1	50.5	0	0	0	0	6	22.7074357394224	0	-1.3	-1.3	0	255	255	0	6.2	6.2	0	181	181	0	5.66	5.66	0	NA	NA	NA	NA	NA	NA	0.001813943	0	0.051845519	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K66A	66	K	A	missense	possibly_low	0.705488596329158	0.1324628429923	8	0.046832687267552	0.613698215985529	0.797278976672788	0.784377558602037	0.512484511618368	0.827014572409787	0.726562655469739	0.822431675003834	0.808005145993342	0.513639469772949	0.64939318176321	0.650313573040761	0.680301139477595	0.544470258384781	0.699663112953729	0.614332453089363	0.687338546415686	0.689585408028555	0.564230097015666	0.620326006603927	p.Lys66Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.722	-3.234	1.512	6.109	6.109	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66C	66	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys66Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.722	-4.101	2.379	11.633	11.633	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66D	66	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys66Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.722	-4.185	2.463	1.571	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66E	66	K	E	missense	low	0.254668711748758	0.135612875716525	8	0.0479463920176817	0.160695510205463	0.348641913292053	0.178017214214601	0.247303020227607	0.358516396536141	0.379098428897107	0.463937828678513	0.0632251157092984	0.135161208646913	0.212090481079881	0.411458814310547	0.391809125650442	0.422226053741189	0.469887028997144	0.46195148101179	0.553427533843998	0.322503671056454	0.360384206221374	0.400691574879906	p.Lys66Glu	1	0	NA	NA	NA	NA	NA	NA	NA	0.101	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.722	-3.832	2.11	3.152	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K66F	66	K	F	missense	low	0.34345601386676	0.129728603439342	2	0.091731975205819	0.163664646232634	0.523247381500887	NA	NA	NA	NA	NA	0.251724038660941	NA	0.435187989072579	0.464075753526868	NA	NA	NA	NA	NA	0.415409642270625	NA	0.512741864783111	p.Lys66Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.722	-2.853	1.131	15.016	15.016	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66G	66	K	G	missense	low	0.229684218069682	0.101016511570135	8	0.0357147301715259	0.159684633215925	0.299683802923438	0.384883942669634	0.206680176352776	0.252915690768237	0.355327202226888	0.166901908566674	0.180627706963355	0.074995137473498	0.215141979536391	0.410797254604211	0.490231457582649	0.403499606379439	0.418094902828984	0.451526572919196	0.442473381520156	0.380368202018875	0.327979157811333	0.402224184050522	p.Lys66Gly	0	0	NA	NA	NA	NA	NA	NA	NA	1.79	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.722	-3.961	2.239	1.706	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66H	66	K	H	missense	low	0.274816899390549	0.139833520054427	6	0.057086795511764	0.162928836194689	0.38670496258641	NA	0.263846490292696	0.300248367779016	0.345230979585407	NA	0.109097628025179	0.490326158997864	0.140151771663135	0.435580822919854	NA	0.42985231502189	0.441309330817818	0.447098858919409	NA	0.345112979597884	0.551673701865856	0.36456049785473	p.Lys66His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.722	-3.975	2.253	9.751	9.751	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66I	66	K	I	missense	low	0.497843306488604	0.201009155072288	7	0.0759743193669272	0.348936376779483	0.646750236197726	0.187063826472713	0.414650480151212	0.456757990077986	0.455625334377213	0.843586228853235	0.623876550149266	NA	0.503342735338604	0.518069860453435	0.396113291338079	0.499370416382024	0.518069860453435	0.49551247335386	0.695240572504873	0.598833451691997	NA	0.546972453668207	p.Lys66Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.722	-3.197	1.475	8.692	8.692	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.86	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66L	66	K	L	missense	low	0.303477118280846	0.0778214949837521	8	0.027514053412543	0.24955056452355	0.357403672038142	0.360767184806897	0.222359075073695	0.371073304560018	0.433561951036498	0.288040042770656	0.238650897961507	0.289994677632127	0.22336981240537	0.459911042535767	0.478757270480536	0.410727314820831	0.476045595456766	0.485836542585558	0.487723057012716	0.408966248247562	0.443776489614768	0.406356597122004	p.Lys66Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.722	-2.192	0.47	11.368	11.368	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K66M	66	K	M	missense	possibly_wt-like	0.717401234040472	0.208572220220476	6	0.0851492523432618	0.550511766137166	0.884290701943778	NA	0.601573858528354	0.653608420898501	1.13676665031691	0.600799536570985	NA	0.694435676892123	0.617223261035958	0.609583098927803	NA	0.585538947975866	0.61461563896102	0.794228047238677	0.604550558894587	NA	0.661605739629297	0.604168726425926	p.Lys66Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.722	-2.52	0.798	6.591	6.591	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.49	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K66N	66	K	N	missense	low	0.127679333119795	0.149787656965813	2	0.105915867978571	-0.0799119535095025	0.335270619749092	NA	NA	NA	NA	0.0217634651412244	NA	NA	0.233595201098365	0.399875480691784	NA	NA	NA	NA	0.388258682658788	NA	NA	0.411492278724779	p.Lys66Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.722	-4.18	2.458	1.96	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	1	2	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	3.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K66P	66	K	P	missense	low	0.145942147491854	0.165764512147992	7	0.0626530964776476	0.0231443348757518	0.268739960107957	0.277075623300042	-0.00641667539136945	0.117052523716994	NA	-0.131922916695737	0.261619085175213	0.324540161905241	0.179647230432598	0.384397015280659	0.438938790688882	0.305265544051422	0.351460478008099	NA	0.33085100545255	0.420286640463626	0.46238245919839	0.384397015280659	p.Lys66Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.722	-3.681	1.959	12.153	12.153	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66Q	66	K	Q	missense	low	0.588499430316894	0.136158254490664	7	0.0514629829044202	0.48763383728723	0.689365023346558	NA	0.663425901486956	0.453079592095288	0.670533149442607	0.608258680462469	0.359746558605597	0.61058559656864	0.753866533556704	0.607336831299721	NA	0.614051698837177	0.516265781105373	0.589760626868122	0.607336831299721	0.468650992254546	0.616444640373925	0.672797544546895	p.Lys66Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.722	-2.838	1.116	6.529	6.529	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.4	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K66R	66	K	R	missense	possibly_wt-like	0.755625806386117	0.267230155648344	8	0.0944801275982401	0.570448159038818	0.940803453733417	0.969930333286276	0.817042123896636	0.933994345022862	1.00466223342722	0.719996669461424	0.513210683648529	0.863997115203288	0.222172947142699	0.710579821843138	0.768582792681599	0.684866192074764	0.752131605851827	0.736293451611512	0.649075196973078	0.544289268380422	0.752930409992307	0.405755473869378	p.Lys66Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.722	-2.215	0.493	17.586	17.586	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.595	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K66S	66	K	S	missense	low	0.439983257239818	0.154494441443862	8	0.0546220336002913	0.33292603862091	0.547040475858726	0.415899020855767	0.438433271560406	0.658997070882633	0.676583673940488	0.333748443424759	0.259305566396934	0.303695943822939	0.433203067034618	0.507660793240988	0.504987703514205	0.510333882967772	0.617258515614398	0.592414093711776	0.504796873697058	0.419146370240049	0.451155901059342	0.511744941546317	p.Lys66Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.722	-3.839	2.117	3.621	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.86	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66T	66	K	T	missense	possibly_low	0.611761990934461	0.216514885225711	8	0.0765495717854635	0.461727587202989	0.761796394665933	0.692341159908751	0.715818518547963	0.805211750954856	0.92502001724708	0.355078605565199	0.531599083976897	0.576164593146178	0.292862198128764	0.617209048726468	0.636512382098931	0.638203813557662	0.688969865485312	0.701366234960604	0.512764496125792	0.553352408714759	0.597905715354005	0.441259012825484	p.Lys66Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.722	-3.139	1.417	9.641	9.641	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.205	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K66V	66	K	V	missense	low	0.598638583729278	0.062849863186661	7	0.0237550154180484	0.55207960905771	0.645197558400847	NA	0.578973460670108	0.649057455989392	0.695056862874999	0.547832359590749	0.506330925177702	0.595511765212944	0.617707256589052	0.600515539190006	NA	0.575120544917943	0.612383607015348	0.600515539190006	0.584765314670198	0.540898423316469	0.608325974400237	0.604411812252048	p.Lys66Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.722	-3.73	2.008	5.643	NA	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66W	66	K	W	missense	low	0.475203733193296	0.198339768085371	7	0.0749653859211597	0.328274276700677	0.622133189685915	0.528765497685582	0.253608415966536	0.4698915749114	NA	0.689888519043366	0.167416080820191	0.670517461088189	0.54633858283781	0.55868692295624	0.55868692295624	0.425132735059806	0.524511259474265	NA	0.637828663872244	0.373856552302638	0.648723546627624	0.568567034532273	p.Lys66Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.722	-3.807	2.085	15.771	15.771	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.51	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K66X	66	K	X	nonsense	low	0.00219135629187329	0.0434829232036578	7	0.0164350001535712	-0.0300206520950365	0.0344033646787831	0.0274503934852614	-0.0632497311143052	-0.00842663669744212	0.00901633439333882	0.030654589964184	NA	0.0615914708658785	-0.0416969268538024	0.299651408094211	0.320172967828082	0.279066461838411	0.289918914811137	0.299651408094211	0.39157985411026	NA	0.320760031535993	0.273227342362871	p.Lys66Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K66Y	66	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys66Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	103.1	31.9	0.997	16.5	-142.3	-131.7	134.3	10.8695652173913	-4.2	0	1	42.21	0	0	1	41	6	20.4698817255987	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.722	-3.157	1.435	12.365	12.365	24.57	0.003609722	0	0.103171858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.745	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67A	67	I	A	missense	low	0.205832390120694	0.0993628072053309	8	0.0351300573863105	0.1369787428687	0.274686037372688	0.1384379668575	0.161160918865556	0.262566871750171	0.391280629530405	0.0613343614194655	0.158897735276709	0.235778501282174	0.237202135983573	0.408171882027018	0.372978249123798	0.382515994746859	0.422828348306012	0.467294003874811	0.40303990929156	0.369658092420413	0.414576015245023	0.413303854762476	p.Ile67Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.387	-2.751	1.364	6.109	6.109	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67C	67	I	C	missense	low	0.506289420537118	0.0757735798552678	5	0.0338869750909775	0.439872169813797	0.57270667126044	NA	0.514441683656776	0.431308661376884	0.624096818385475	0.448396568765813	NA	NA	0.513203370500645	0.547622285377722	NA	0.545372481756144	0.505588174527212	0.569395902315039	0.547622285377722	NA	NA	0.551924938518789	p.Ile67Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.387	-4.989	3.602	1.023	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67D	67	I	D	missense	low	0.212329359964604	0.296855256962431	5	0.132757706809233	-0.0478709640516204	0.472529683980828	NA	0.183049145907188	0.321086133686634	NA	-0.148798566177061	0.644470750315427	NA	0.0618393360908309	0.392606099043843	NA	0.392606099043843	0.451529264416765	NA	0.324547312005611	0.608983770525952	NA	0.325228229252295	p.Ile67Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.387	-4.247	2.86	0.99	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67E	67	I	E	missense	low	0.31100195140485	0.266578720131726	8	0.0942498103625871	0.12627571754445	0.495728185265251	0.733401008939398	0.191283878694883	0.386483352189823	0.633117022401534	-0.0312157518078226	0.0578804583671336	0.193145166622618	0.323920475831237	0.42663007236315	0.656047694135632	0.396402172272049	0.4836034912615	0.573351726688279	0.368468941050604	0.319869435415181	0.391613982880595	0.45685797245425	p.Ile67Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.387	-4.102	2.715	1.278	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67F	67	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile67Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.387	-3.124	1.737	9.947	9.947	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67G	67	I	G	missense	low	0.181295838640825	0.0615244650190394	8	0.0217521832119186	0.138662342960348	0.223929334321302	0.215981179971884	0.157803183786206	0.208588991968511	0.290260678964216	0.197314172892969	0.170277210687855	0.0971639762327708	0.11297731462219	0.388661449819982	0.409871489120547	0.380968135384478	0.396354764255486	0.422991548861398	0.453833512669622	0.375266725076906	0.339919147895081	0.35091217960682	p.Ile67Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.387	-3.238	1.851	10.627	10.627	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67H	67	I	H	missense	low	0.296679035814013	0.384843139837854	5	0.17210708427038	-0.0406446508401318	0.634002722468158	0.202051242880606	0.00803055790480219	0.163587529398586	NA	0.972662766682802	NA	NA	0.137063082203269	0.374283686129399	0.403243952143325	0.311925475460392	0.374283686129399	NA	0.743455542042509	NA	NA	0.363009209574942	p.Ile67His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.387	-5.202	3.815	0.488	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67I	67	I	I	synonymous	low	0.100378820451673	0.0414104642985348	2	0.0292816201175774	0.0429878996122382	0.157769741291108	NA	0.129660440569251	0.071097200334096	NA	NA	NA	NA	NA	0.348458190444492	NA	0.367994804391419	0.328921576497566	NA	NA	NA	NA	NA	p.Ile67=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	NA	NA	NA	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
I67K	67	I	K	missense	low	0.272300803355096	0.155945073333593	6	0.0636643095947011	0.147521049448874	0.397080557261317	0.504274886015002	0.193814808839633	0.360331169826777	NA	0.335451619829384	0.0782933366832269	NA	0.161638998936551	0.434172988750228	0.54703486499087	0.397568888474341	0.470777089026115	NA	0.505433074511296	0.32993038566114	NA	0.375352416002382	p.Ile67Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.387	-4.102	2.715	1.456	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	1	0	1	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I67L	67	I	L	missense	possibly_wt-like	0.751155881240532	0.394443396366917	8	0.13945680018265	0.477825575483339	1.02448618699772	1.23922996941272	0.847650224796089	1.01477981321794	1.02436090992656	0.369176168416469	0.263330608102859	0.249925433542896	1.00079392250873	0.7219541740093	0.896709236087989	0.698976011468573	0.79175303764897	0.744932336550026	0.518030469127999	0.421130203372944	0.422195459490285	0.796816345859643	p.Ile67Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.387	-2.348	0.961	12.3	12.3	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I67M	67	I	M	missense	low	0.505695191818352	0.257375757817649	7	0.097278892668898	0.315032065731374	0.696358317905329	NA	0.834257585121892	0.46602104742752	0.657950869660334	0.754830103918344	0.442097577771646	0.158686574508224	0.226022584320503	0.522612949739262	NA	0.692802229970987	0.522612949739262	0.584242648677714	0.662086802408678	0.5092395605938	0.373054812839554	0.407688946661952	p.Ile67Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.387	-4.398	3.011	1.739	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I67N	67	I	N	missense	low	0.117791044822335	0.0148336751982138	3	0.00856422636876023	0.101005469584116	0.134576620060553	NA	0.113795970839472	NA	NA	NA	NA	0.105364038223423	0.134213125404109	0.36068155083802	NA	0.36068155083802	NA	NA	NA	NA	0.34433564710452	0.361577824310128	p.Ile67Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.387	-4.424	3.037	0.904	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67P	67	I	P	missense	low	0.382789361193514	0.36313958328798	7	0.137253861226232	0.113776736451042	0.651801985935987	NA	0.832910652352321	0.637339709004015	0.561164411352612	-0.115210494347128	-0.0396869389653998	0.581516405253745	0.221491783704435	0.541796798218939	NA	0.6921813166325	0.606636609153354	0.541796798218939	0.337093727390927	0.271781129837204	0.60078816599512	0.405413360856034	p.Ile67Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.387	-4.325	2.938	0.936	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67Q	67	I	Q	missense	low	0.0794922019947107	0.164386792596765	5	0.0735160085699052	-0.0645965270894415	0.223580931078863	NA	0.337848525430228	NA	NA	-0.102978876575893	-0.00939495050164469	0.0803835538980002	0.0916027577228632	0.340176849935632	NA	0.463966007798677	NA	NA	0.341662699321478	0.286711223676285	0.3308813232957	0.340176849935632	p.Ile67Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.387	-4.544	3.157	0.877	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67R	67	I	R	missense	low	0.219541790464059	0.14960246165661	8	0.0528924575597945	0.115874478593048	0.323209102335069	0.0679057713285143	0.321519746787136	0.325820726197931	0.397044174181754	-0.0353969523827824	0.187233207264662	0.165412156059662	0.326795494275593	0.418737614846575	0.339420686667494	0.456438715650355	0.453851356972082	0.469821615264473	0.366907104470988	0.383623872721068	0.376677166626489	0.458301944881668	p.Ile67Arg	1	0	NA	NA	NA	NA	NA	NA	NA	10.236	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.387	-4.447	3.06	1.189	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I67S	67	I	S	missense	low	0.298870931414554	0.101266672674914	8	0.035803175478315	0.228697996944889	0.369043865884219	0.210830416618296	0.272382819500011	0.444493644495765	0.347535136116121	0.424232721244894	0.307991419824696	0.214215829061296	0.169285464455354	0.438464858453469	0.407420876862707	0.433787419123806	0.51205478196371	0.448109350317135	0.538596174267804	0.443142297783133	0.402962502453844	0.379192838451856	p.Ile67Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.387	-3.892	2.505	1.777	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67T	67	I	T	missense	low	0.228353849380359	0.127222341495354	5	0.0568955607680606	0.11684059939475	0.339867099365968	0.218166493337654	NA	NA	NA	0.045783736847621	0.186529868800583	0.377605448425554	0.313683699490383	0.41091120990633	0.41091120990633	NA	NA	NA	0.397231162770851	0.383277216400308	0.490963071909949	0.451716571427465	p.Ile67Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.387	-3.668	2.281	2.738	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	1	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I67V	67	I	V	missense	possibly_wt-like	0.781417896590732	0.220597365105427	8	0.0779929463889661	0.628554530620195	0.934281262561269	0.797376063339966	0.769220429768648	1.01588109722801	1.11704003971275	0.43714347361279	0.817593113843664	0.555057820414744	0.742031134805282	0.676669380666383	0.686485522812187	0.662821195899783	0.792293165103442	0.785576911755441	0.543418828660255	0.694311055534418	0.586537747015663	0.66685323852058	p.Ile67Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.387	-1.271	-0.116	14.764	14.764	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.63	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
I67W	67	I	W	missense	low	0.384040043068352	0.134391563967604	5	0.0601017345268146	0.266242807987408	0.501837278149296	NA	0.332047722108809	0.509549884113658	NA	0.514081613355214	NA	0.372147890171832	0.192373105592248	0.488023667093192	NA	0.461291935092465	0.543961774874547	NA	0.572158134240804	NA	0.488023667093192	0.39078856135278	p.Ile67Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.387	-5.573	4.186	0.462	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I67X	67	I	X	nonsense	possibly_low	0.313638541560119	0.537354409570207	3	0.310241713015592	-0.294424042452452	0.921701125572689	0.077024628860651	-0.0648040906378712	NA	NA	0.928695086457576	NA	NA	NA	0.34375922496011	0.34375922496011	0.278349928257233	NA	NA	0.727031950285664	NA	NA	NA	p.Ile67Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I67Y	67	I	Y	missense	low	0.326527084231601	0.237988551510105	6	0.0971584193039712	0.136100081600976	0.516954086862225	0.403086222281607	NA	0.727439001474943	0.251974585428736	0.0161458915317702	0.352455855665716	NA	0.208060949006831	0.435629363709665	0.498891674811742	NA	0.650826029000342	0.406201123534635	0.386160306416214	0.465057603884696	NA	0.398667750225736	p.Ile67Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.4	100.4	29.5	0.719	5.1	-158.4	-100.4	147.9	0	-5.2	0	1	37.68	0	0	0	0	7	16.9502465427498	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.387	-4.233	2.846	2.307	NA	24.57	0.003019766	0	0.086309941	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68A	68	Y	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr68Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.381	-3.595	2.214	2.684	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68C	68	Y	C	missense	low	0.06951562339011	0.0214077196339871	2	0.0151375437229327	0.0398465828787616	0.0991846639014584	0.0543780796671773	0.0846531671130427	NA	NA	NA	NA	NA	NA	0.340115868700664	0.332984528620657	0.34724720878067	NA	NA	NA	NA	NA	NA	p.Tyr68Cys	1	0	NA	NA	NA	NA	NA	NA	NA	7.991	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.381	-3.57	2.189	12.592	12.592	24.57	0.002846509	0	0.081357977	0	NA	NA	Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Sep 10, 2015)	criteria provided, single submitter	1	0	0	0	0	4	1	2	0	1	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y68D	68	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr68Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.381	-4.29	2.909	1.203	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y68E	68	Y	E	missense	low	0.246852117535303	0.0746088013161722	5	0.0333660702925474	0.181455821456278	0.312248413614327	NA	0.224976967298301	0.245820928453678	0.238121662307991	NA	0.365650229202622	0.159690800413922	NA	0.411934119078403	NA	0.411934119078403	0.414615259182128	0.400125902749816	NA	0.471560750262478	0.37359568227733	NA	p.Tyr68Glu	0	0	yes	NA	NA	NA	NA	NA	NA	12.996	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.381	-4.108	2.727	2.179	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68F	68	Y	F	missense	wt-like	1.07905689514814	0.408459682980056	6	0.166752967300019	0.752227084924915	1.40588670537136	0.395795472239412	1.0391475544214	1.12703077407196	1.23156428422453	1.65945922740996	NA	NA	1.02134405852158	0.821469653717039	0.495422907136791	0.787253057610237	0.846806797799269	0.8358016956916	1	NA	NA	0.807137611742478	p.Tyr68Phe	1	0	NA	NA	NA	NA	NA	NA	NA	0.818	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.381	-1.96	0.579	12.338	12.338	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.745	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
Y68G	68	Y	G	missense	low	0.218393738270792	0.300720130275377	6	0.122768479092993	-0.0222280591882324	0.459015535729816	0.191773923717292	0.384393585262602	0.278470187341934	0.275352090311451	-0.348089107317915	NA	NA	0.528461750309387	0.423540766463896	0.398354245008595	0.485422497048572	0.43062816859728	0.416453364330513	0.250104756202536	NA	NA	0.559588430130173	p.Tyr68Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.381	-3.973	2.592	1.646	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68H	68	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr68His	1	0	yes	0.127513408858955	-2.07296266024129	0.114133426887835	0.140893390830074	0.172307019	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.381	-3.7	2.319	9.4	9.4	24.57	0.002846509	0	0.081357977	0	NA	NA	not provided|Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic(Last reviewed: Jul 13, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	15	5	0	1	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y68I	68	Y	I	missense	possibly_low	0.360719381995918	0.490449849492715	6	0.20022531261366	-0.0317150195201286	0.753153783511965	-0.103167825974779	0.0204443319846169	0.105015933524249	NA	1.17816216694135	0.248751269993163	NA	0.715110415506914	0.379750774245296	0.258027886073747	0.317648016392843	0.345557102709953	NA	0.820217341592407	0.413944445780638	NA	0.653332359560858	p.Tyr68Ile	0	0	NA	NA	NA	NA	NA	NA	NA	6.138	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.381	-2.477	1.096	9.096	9.096	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.22	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68K	68	Y	K	missense	low	0.207062977864806	0.103549427909658	5	0.0463087119674417	0.116299570238182	0.297826385491431	0.359389968611603	0.0944118640125698	0.145193192351704	0.256382931599973	NA	NA	NA	0.179936932748182	0.38454251770576	0.478102023353422	0.351745803816787	0.36526213823174	0.408134410542203	NA	NA	NA	0.38454251770576	p.Tyr68Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.381	-4.12	2.739	1.907	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68L	68	Y	L	missense	low	0.178098496742832	0.144241273469052	8	0.050996991298475	0.0781462304779183	0.278050763007745	0.252540200750063	0.212174846884604	0.313775281310723	0.385257956223611	-0.0576461130137991	0.0445872415340913	0.116531413766327	0.157567146487034	0.389669946521546	0.427265412759304	0.40603255702173	0.447943638867233	0.464652751213932	0.358596201342498	0.313317571876145	0.350350321787829	0.373307336021362	p.Tyr68Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.381	-2.628	1.247	9.225	9.225	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y68M	68	Y	M	missense	low	0.230106952333542	0.0291165728080269	2	0.0205885260774676	0.189754182726941	0.270459721940142	NA	0.250695478411009	0.209518426256074	NA	NA	NA	NA	NA	0.410300263730281	NA	0.423789919870162	0.396810607590399	NA	NA	NA	NA	NA	p.Tyr68Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.381	-3.756	2.375	4.059	4.059	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68N	68	Y	N	missense	low	0.107193178374888	0.186823557203736	6	0.0762703978468031	-0.0422940544913876	0.256680411241163	NA	0.12122827549792	0.325665843758982	0.235256908058414	-0.216706202335373	NA	0.0408760399309587	0.136838205338425	0.363501991904836	NA	0.364107718203155	0.453775394498527	0.398869560358486	0.29918124111619	NA	0.309602837303614	0.362896265606518	p.Tyr68Asn	1	0	NA	0.140191500083525	-2.01902344780251	0.108118217190496	0.172264782976554	NA	NA	8.028	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.381	-4.361	2.98	1.449	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	not specified	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, single submitter	0	0	1	0	0	3	0	0	0	3	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y68P	68	Y	P	missense	low	0.102007728740357	0.128374069012608	6	0.052408494214287	-0.000711032403621109	0.204726489884335	0.0432086874510564	-0.0644646587643868	0.282014276540046	0.223204262204811	NA	0.0890954453507436	NA	0.0389883596598732	0.331462422045943	0.327670394074294	0.27850640063842	0.432366375871228	0.393583853943771	NA	0.335254450017593	NA	0.313751370740079	p.Tyr68Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.381	-4.508	3.127	0.715	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68Q	68	Y	Q	missense	low	0.245018415747068	0.35008282306766	7	0.132318869730351	-0.0143218033994665	0.504358634893602	NA	0.199789382700928	0.133464097461967	0.298632222518618	-0.190987376535237	0.955770143255657	0.0960039267140623	0.222456514113479	0.400323066474955	NA	0.400323066474955	0.35950957476211	0.426662902189459	0.308788195434523	0.762414739714639	0.339294352888881	0.405897894829472	p.Tyr68Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.381	-3.639	2.258	4.512	4.512	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68R	68	Y	R	missense	low	0.200530883629864	0.12015896595218	8	0.0424826098225749	0.117266498408349	0.283795268851378	0.195940085903205	0.179264467740957	0.249074744519284	0.311715590690349	0.0241581421213483	0.111826974658545	0.127764069707124	0.404502993698097	0.395598916627044	0.400336407150413	0.390861426103675	0.416211101283489	0.432400633465344	0.389153185095797	0.346458200014968	0.356400156062128	0.497330385478278	p.Tyr68Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.381	-4.384	3.003	1.53	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68S	68	Y	S	missense	low	0.219539581505228	0.134562865752819	6	0.0549350599035067	0.111868842605805	0.327210320404652	0.0988745586296602	0.125747955000439	0.309203315453435	0.445858328640936	NA	0.131591994699411	NA	0.205961336607489	0.381902219183694	0.354154908482936	0.366191214389604	0.445701306954815	0.491229137935242	NA	0.356199838610088	NA	0.397613223977785	p.Tyr68Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.381	-3.398	2.017	5.403	5.403	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y68T	68	Y	T	missense	low	0.159831918203441	0.178464146658935	7	0.0674531071429859	0.0276262575578673	0.292037578849015	0.220237987134469	0.209407233497085	0.17865182867758	0.38842405110468	-0.164397276136347	NA	0.0276923506985263	0.258807252448094	0.404756733827796	0.411896778013818	0.404756733827796	0.38167200880413	0.466041247003632	0.318720603773737	NA	0.302502189389135	0.424154982527298	p.Tyr68Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.381	-3.938	2.557	2.018	NA	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68V	68	Y	V	missense	low	0.251945617974147	0.116529764275326	8	0.0411994932645764	0.171196094994277	0.332695140954018	0.393882572467058	0.306551709294604	0.392943177273893	0.281651210228219	0.0734233086621797	0.186437163855107	0.129464879594329	0.251210922417787	0.419777796803882	0.494512794342173	0.449538702271767	0.486771728380234	0.419215853078257	0.407555588382822	0.383231524664457	0.357316201029936	0.420339740529506	p.Tyr68Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.381	-2.72	1.339	8.818	8.818	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.68	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y68W	68	Y	W	missense	possibly_wt-like	0.714731057175096	0.296771746433856	7	0.1121691767449	0.494883510579584	0.934578603770608	1.13580103584492	0.462736577483588	0.575336777979475	0.768448492719825	0.356847710253763	1.07510109201928	NA	0.628845713924814	0.610006080806529	0.847500178125746	0.521537297984439	0.576227118960394	0.632701551570116	0.513425323647991	0.821229705430051	NA	0.610006080806529	p.Tyr68Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.381	-3.084	1.703	11.459	11.459	24.57	0.002846509	0	0.081357977	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y68X	68	Y	X	nonsense	low	0.0080975202513093	0.117809736184804	8	0.0416520316730365	-0.0735389617107639	0.0897340022133825	-0.063870740991153	-0.089654193160925	0.000770804595461111	0.00145261420734789	0.279479069231273	0.0426846832952903	-0.0522630731908051	-0.0538190019760147	0.285577169454503	0.276724516368585	0.266894449210371	0.294429822540421	0.29633432694939	0.484525209554498	0.312379852879137	0.259438726356767	0.267139053686349	p.Tyr68Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.2	96.6	30.2	0.972	6.7	-158.9	-124.3	113.5	0	-5.4	0	1	30.8	1	39	0	0	7	14.4253186398083	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N69A	69	N	A	missense	possibly_wt-like	0.731309977010192	0.174979129289664	7	0.0661358943895813	0.601686005921268	0.860933948099115	0.730008557545068	0.769995428620035	0.88159180884259	1.01270819702683	0.558801293308503	NA	0.525124892266778	0.640939661461541	0.654433645420837	0.654433645420837	0.663178457327384	0.726430652949625	0.73982202134861	0.588862626342441	NA	0.570416069685372	0.616080242457894	p.Asn69Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-0.945	-3.487	2.542	2.684	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69C	69	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn69Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-0.945	-3.594	2.649	15.47	15.47	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69D	69	N	D	missense	wt-like	1.03077409646512	0.0695253348594605	6	0.0283835991003024	0.975143264476907	1.08640492845334	NA	1.05138626112207	0.922473534827865	1.04354637460403	1.05853418813314	1.12495447802254	NA	0.983749742081096	0.781893852811525	NA	0.79289489542721	0.746481196123599	0.753346151653093	0.775531766265756	0.845801077894265	NA	0.788255939357294	p.Asn69Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-0.945	-2.909	1.964	11.124	11.124	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69E	69	N	E	missense	wt-like	0.862932238619164	0.118036264872558	3	0.0681482692983095	0.729364085185741	0.996500392052588	NA	NA	NA	NA	0.998972180604605	0.802151774758373	0.787672760494515	NA	0.711822616829708	NA	NA	NA	NA	0.753283103364828	0.686700441202503	0.711822616829708	NA	p.Asn69Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-0.945	-3.55	2.605	2.57	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69F	69	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn69Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-0.945	-3.372	2.427	8.13	8.13	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69G	69	N	G	missense	low	0.408556086437003	0.0694423930180917	8	0.024551593502457	0.360435847409119	0.456676325464886	0.518527330406437	0.337197653696617	0.435538487562935	0.440805514067737	0.32880836536645	0.387831492284305	0.346587677323941	0.473152170787602	0.495982392993808	0.553815843368666	0.463665966883366	0.507662703195409	0.489013218316734	0.502951567670882	0.482493289064779	0.474257105332502	0.531809301283771	p.Asn69Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-0.945	-3.323	2.378	1.646	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69H	69	N	H	missense	possibly_low	0.278101800261876	0.511918357440505	2	0.36198094196006	-0.431367809069725	0.987571409593477	NA	NA	NA	NA	NA	-0.0838791416981843	NA	0.640082742221936	0.432824928217413	NA	NA	NA	NA	NA	0.25	NA	0.615649856434826	p.Asn69His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-0.945	-3.101	2.156	12.387	12.387	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69I	69	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn69Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-0.945	-3.274	2.329	5.727	5.727	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69K	69	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn69Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-0.945	-3.579	2.634	2.967	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69L	69	N	L	missense	possibly_wt-like	0.871169807463882	0.244138186705376	6	0.0996689973594174	0.675822162264207	1.06651745266356	NA	0.849240512436499	0.968959813494491	1.17684011575555	0.642240697059995	0.539440834274299	1.05029687176246	NA	0.734494806633695	NA	0.699709107306962	0.769280505960427	0.811802327268283	0.620030399957726	0.557217393278018	0.853270227971752	NA	p.Asn69Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-0.945	-3.046	2.101	12.3	12.3	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69M	69	N	M	missense	wt-like	0.943194103054702	0.19011861612894	4	0.0950593080644698	0.756881282853044	1.12950692325636	1.22735034069704	0.857551823004731	0.861992613640612	0.825881634876429	NA	NA	NA	NA	0.710179330503131	0.891057187692299	0.703540481603226	0.716818179403035	0.65788894457923	NA	NA	NA	NA	p.Asn69Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-0.945	-4.844	3.899	1.632	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69P	69	N	P	missense	low	0.151820171998374	0.157337290396061	3	0.090838726963732	-0.0262204612520082	0.329860805248756	NA	NA	0.330942390903796	NA	0.0359637023090551	NA	NA	0.088554422782271	0.393563008402156	NA	NA	0.456363290038326	NA	0.393563008402156	NA	NA	0.338645829634739	p.Asn69Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-0.945	-4.171	3.226	0.715	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69Q	69	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn69Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-0.945	-4.013	3.068	1.4	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69R	69	N	R	missense	low	0.290662478717157	0.175616277705503	8	0.0620897304261506	0.168968843272101	0.412356114162213	0.524828104490611	0.308702567930937	0.27430416003913	0.346036906393446	-0.0807906394463455	0.213641275470569	0.392961214695427	0.345616240163479	0.448991255634145	0.556813603728555	0.450530211905115	0.428584930248465	0.447452299363175	0.349950845217579	0.396639688334981	0.499233586165637	0.467754627934502	p.Asn69Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-0.945	-3.15	2.205	8.452	8.452	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69S	69	N	S	missense	wt-like	0.952882455611292	0.0982116427107555	8	0.0347230592761228	0.884826509997042	1.02093840122554	1.02230448412348	1.03412240923183	1.02712572396128	1.00429346726626	0.839315831015665	0.77089912480671	0.992028151144043	0.932970453341069	0.773844345251171	0.793501183845153	0.784936550248822	0.797808119972807	0.736131728643277	0.693645417373552	0.671296863551714	0.821887080034627	0.762752140253519	p.Asn69Ser	1	0	NA	NA	NA	NA	NA	NA	NA	1.598	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-0.945	-2.866	1.921	5.403	5.403	24.57	0.00072501	0	0.020721992	0	NA	NA	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Sep 21, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69T	69	N	T	missense	possibly_wt-like	0.794461916054572	0.232626939539316	5	0.104033930041529	0.590559160003016	0.998364672106128	NA	0.876701847423326	0.849803112819919	1.01246592694669	NA	NA	0.397707051484119	0.835631641598809	0.712368320573733	NA	0.712368320573733	0.710839808710894	0.739715773431576	NA	NA	0.501789662503753	0.713863911188627	p.Asn69Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-0.945	-3.539	2.594	2.018	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N69V	69	N	V	missense	wt-like	0.857623239979445	0.0878799852673141	8	0.0310702667565458	0.796726636146563	0.918519843812327	0.745389446992016	0.86064362564757	0.754531549300724	0.910155865397913	0.797162391573154	0.987518547674514	0.944375529094671	0.861208964154995	0.699906644423162	0.66175151145887	0.7049657505879	0.66411363579242	0.694847538258423	0.677899513177463	0.778062661203245	0.796221692645038	0.726710071744854	p.Asn69Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-0.945	-3.819	2.874	3.718	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69W	69	N	W	missense	possibly_wt-like	0.840788823806946	0.209970151935758	5	0.0939015065948628	0.656745252786965	1.02483239482693	0.789791461146702	1.06439004523463	0.906821953748284	0.93468083711295	0.508259821792167	NA	NA	NA	0.7056030024021	0.682876947183741	0.798889421055149	0.738804839643686	0.7056030024021	0.569983474867484	NA	NA	NA	p.Asn69Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-0.945	-5.642	4.697	0.378	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N69X	69	N	X	nonsense	low	-0.0344503385336618	0.0385786292028729	3	0.0222733819552454	-0.0781053649798472	0.0092046879125235	NA	0.00978791175830401	-0.0611019618320761	-0.0520369655272134	NA	NA	NA	NA	0.272876389318307	NA	0.312735586011366	0.264084171894571	0.272876389318307	NA	NA	NA	NA	p.Asn69Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N69Y	69	N	Y	missense	low	0.510685867091541	0.0918776455848459	2	0.0649673062324988	0.383352286703259	0.638019447479823	NA	NA	NA	NA	0.445718560859042	NA	NA	0.57565317332404	0.5649560893833	NA	NA	NA	NA	0.546621948121876	NA	NA	0.583290230644725	p.Asn69Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	94.3	27.1	0.854	15.3	175.9	-98.5	116.2	0.53475935828877	-5.7	0	1	25.52	1	2	0	0	6	12.0726433667197	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-0.945	-4.266	3.321	2.031	NA	24.57	0.00072501	0	0.020721992	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L70A	70	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.011	-3.381	2.37	1.806	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70C	70	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.011	-3.624	2.613	13.551	13.551	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70D	70	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.011	-4.342	3.331	0.755	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70E	70	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.011	-4.133	3.122	1.282	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70F	70	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Phe	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.011	-2.369	1.358	11.956	11.956	24.57	0.001590104	0	0.045447821	0	NA	NA	not specified	Uncertain significance(Last reviewed: Feb 11, 2015)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L70G	70	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Gly	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.011	-4.019	3.008	0.874	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70H	70	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70His	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.011	-5.098	4.087	0.591	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
L70I	70	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.011	-2.724	1.713	8.692	8.692	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.1	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L70K	70	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.011	-3.97	2.959	2.967	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70M	70	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.011	-2.975	1.964	4.582	4.582	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L70N	70	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.011	-4.385	3.374	0.942	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.65	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70P	70	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Pro	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.011	-4.39	3.379	0.475	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	Cowden syndrome 1	Pathogenic(Last reviewed: Nov 1, 1998)	no assertion criteria provided	1	0	0	0	0	1	1	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	.	D	0.857142857142857
L70Q	70	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.011	-4.408	3.397	1.183	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70R	70	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.011	-3.402	2.391	8.452	8.452	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
L70S	70	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.011	-3.888	2.877	1.185	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70T	70	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.011	-3.733	2.722	1.288	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.65	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70V	70	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Val	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.011	-2.308	1.297	6.948	6.948	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L70W	70	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.011	-5.309	4.298	0.555	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L70X	70	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L70Y	70	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu70Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.5	90.9	27.8	0.303	42.3	123.3	-96.3	3.7	0	-5.9	0	1	24.49	0	0	0	0	6	9.41070124167164	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.011	-4.084	3.073	2.773	NA	24.57	0.001590104	0	0.045447821	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71A	71	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-1.189	-2.642	1.453	7.116	7.116	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C71D	71	C	D	missense	possibly_wt-like	0.849150452876448	0.169436733581217	3	0.0978243437437267	0.657418262327478	1.04088264342542	NA	1.02736281182479	0.829966180021177	0.690122366783375	NA	NA	NA	NA	0.701110736174581	NA	0.781820489605223	0.701110736174581	0.598351508323946	NA	NA	NA	NA	p.Cys71Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-1.189	-4.01	2.821	1.422	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71E	71	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-1.189	-3.935	2.746	2.179	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71F	71	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Phe	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-1.189	-4.401	3.212	1.155	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	1	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C71G	71	C	G	missense	possibly_wt-like	0.925646245912719	0.224222115477494	3	0.129454698729199	0.671919698774007	1.17937279305143	NA	0.762804148574394	0.83274748626956	1.1813871028942	NA	NA	NA	NA	0.702474834672608	NA	0.659863398252415	0.702474834672608	0.813796415485784	NA	NA	NA	NA	p.Cys71Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-1.189	-3.682	2.493	1.945	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C71H	71	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-1.189	-4.972	3.783	0.746	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71I	71	C	I	missense	low	0.279917666880116	0.26509367032621	6	0.108224037723466	0.0678024506806182	0.492032883079614	NA	0.432133719017452	0.592434782346878	0.518475161191598	0.0176555477872092	-0.00220996043618837	0.121016751373746	NA	0.447077057699243	NA	0.507429895264161	0.584612877303398	0.523075361767874	0.386724220134325	0.290252509057351	0.352766094988058	NA	p.Cys71Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-1.189	-3.94	2.751	2.427	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71K	71	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-1.189	-3.775	2.586	3.746	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.435	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71L	71	C	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-1.189	-3.006	1.817	7.92	7.92	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71M	71	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-1.189	-4.756	3.567	1.051	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71N	71	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-1.189	-4.06	2.871	1.596	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71P	71	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-1.189	-4.234	3.045	0.845	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71Q	71	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-1.189	-3.424	2.235	4.512	4.512	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71R	71	C	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-1.189	-2.346	1.157	10.671	10.671	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.875	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C71S	71	C	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-1.189	-2.231	1.042	6.385	6.385	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	medium	3.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C71T	71	C	T	missense	possibly_low	0.562915588888726	0.183589046454326	5	0.0821035175592479	0.401995651468548	0.723835526308904	NA	0.863421604264772	0.396308297815111	0.582699444110601	0.438338941979615	NA	NA	0.533809656273531	0.551241020024888	NA	0.706246351978275	0.488422160035727	0.551241020024888	0.543865381316987	NA	NA	0.562274405509499	p.Cys71Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-1.189	-2.721	1.532	6.529	6.529	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C71V	71	C	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-1.189	-3.66	2.471	2.021	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C71W	71	C	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Trp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-1.189	-5.485	4.296	0.16	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C71X	71	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C71Y	71	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys71Tyr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	43.8	89.9	24.2	0.598	33.1	175.2	-76	103.1	2.7027027027027	-0.7	0	1	37.7	0	0	0	0	7	8.99792853161215	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-1.189	-4.462	3.273	0.557	NA	19.11	0.00248246	0	0.070952848	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	6	2	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A72A	72	A	A	synonymous	wt-like	1.06095857014735	0.231618473068582	8	0.0818894964774339	0.900458106339461	1.22145903395524	0.504213113643285	1.04482570565531	1.14111567930303	1.21047169807587	1.17373113922362	1.19761513684603	1.127015648732	1.08868043969966	0.833754343940169	0.547005475146893	0.78987058976829	0.853714774251604	0.826551509528071	0.818562185124603	0.88161353226457	0.894590454358009	0.840957178352267	p.Ala72=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A72C	72	A	C	missense	possibly_low	0.662899440777201	0.413602532110821	5	0.184968675493167	0.300367498542517	1.02543138301189	0.665322871664748	0.59663868352319	1.09979952788577	NA	0.018436701214046	NA	NA	0.934299419598251	0.623657714972654	0.623657714972654	0.583263915355304	0.833451166054811	NA	0.387016010488424	NA	NA	0.763419610973962	p.Ala72Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.319	-3.488	1.169	13.791	13.791	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A72D	72	A	D	missense	possibly_wt-like	0.767448347034691	0.185215844723102	8	0.0654836898934502	0.639102673268739	0.895794020800643	0.572260304019404	0.71736986824353	0.625404869349201	1.13860254260133	0.759649628248937	0.92742297661953	0.641589721968593	0.757286865226998	0.65140301835804	0.579380730502218	0.638918959658788	0.600783137657079	0.795033180629501	0.663887077057292	0.748443195441279	0.633143257466616	0.674515399482478	p.Ala72Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.319	-2.94	0.621	13.88	13.88	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.365	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
A72E	72	A	E	missense	possibly_low	0.653062602390967	0.476563959433107	6	0.194556421735256	0.271739022828881	1.03438618195305	0.806504566843373	0.820832603734622	0.934225554631251	NA	-0.277172393302149	0.609943179542029	NA	1.02404210289668	0.688721094959704	0.690828650431435	0.686613539487972	0.752245003173577	NA	0.276594831497972	0.591966073840271	NA	0.808492699287478	p.Ala72Glu	0	0	NA	NA	NA	NA	NA	NA	NA	1.965	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.319	-3.183	0.864	9.877	9.877	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.51	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A72F	72	A	F	missense	possibly_wt-like	0.932228108310229	0.458326039241905	2	0.324085450342322	0.297032297725833	1.56742391889463	NA	NA	NA	NA	1.25631355865255	NA	NA	0.608142657967907	0.724508926928327	NA	NA	NA	NA	0.849409842677732	NA	NA	0.599608011178922	p.Ala72Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.319	-4.552	2.233	2.884	NA	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A72G	72	A	G	missense	wt-like	0.905205042460077	0.0735721983641389	8	0.0260117001850422	0.854223046920741	0.956187037999414	0.89711398951689	0.90688238708556	0.954590440384664	1.06197377829643	0.835201949103894	0.862545439599942	0.873809193514671	0.849523162178571	0.730109763779884	0.733938486126918	0.726281041432851	0.762233011536505	0.761427517942831	0.692108726861142	0.71646682925093	0.758215130541319	0.72084090040811	p.Ala72Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.319	-2.243	-0.076	15.814	15.814	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.195	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A72H	72	A	H	missense	wt-like	0.823002002246098	0.118773718795928	6	0.0484891676504731	0.727964980010846	0.91803902448135	NA	0.714374904648572	0.767166318760599	1.00730179411354	0.897293411383137	NA	0.852432252960336	0.699443331610398	0.69280631318988	NA	0.637538331845428	0.670310389585048	0.737451035018606	0.715302236794712	NA	0.746701651598591	0.645463597115515	p.Ala72His	0	0	NA	NA	NA	NA	NA	NA	NA	0.953	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.319	-4.999	2.68	1.407	NA	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A72I	72	A	I	missense	wt-like	0.851082399921024	0.121810257224125	7	0.0460399496788347	0.760845756700472	0.941319043141577	NA	0.981941283161639	0.888975273829028	0.979303875779656	0.822567847641235	0.622695152937223	0.842206753053397	0.819886613044991	0.725172504782704	NA	0.760881929315804	0.730051891532786	0.725172504782704	0.687389412046843	0.598251173270159	0.741194264909735	0.705956001190603	p.Ala72Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.059	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.319	-3.208	0.889	13.404	6.333	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.715	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A72K	72	A	K	missense	possibly_wt-like	0.772515173937322	0.245667651913845	3	0.141836284963642	0.494521163707625	1.05050918416702	NA	NA	NA	NA	0.549647780056917	NA	0.73196140838282	1.03593633337223	0.681816850673482	NA	NA	NA	NA	0.585443442887348	NA	0.681816850673482	0.814466553432925	p.Ala72Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.319	-2.803	0.484	10.175	10.175	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.265	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A72L	72	A	L	missense	possibly_low	0.627053434966648	0.264857636141941	8	0.0936413152825028	0.443519829547982	0.810587040385313	0.72196095697378	0.618828958051183	0.843286511045596	0.827260876184873	0.618456006711515	0.00527209038409512	0.703895217396208	0.67746686298593	0.642515372242884	0.650604786035857	0.593493258460175	0.707643725324622	0.658493812980744	0.611145918394328	0.293940207571738	0.666700585644555	0.63442595844991	p.Ala72Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.319	-2.89	0.571	15.095	15.095	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.915	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
A72M	72	A	M	missense	possibly_wt-like	0.837797569155311	0.227498077597456	5	0.101740233251687	0.638390376203301	1.03720476210732	1.12602010815871	NA	NA	NA	0.521812089155748	0.782510408059534	0.785521991815166	0.973123248587396	0.71066422702938	0.842846642399983	NA	NA	NA	0.575045759377809	0.677019747962694	0.71066422702938	0.782918803647726	p.Ala72Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.319	-3.954	1.635	3.979	3.979	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A72N	72	A	N	missense	wt-like	0.876647644092384	0.13635589169846	8	0.0482090878373598	0.782159568203631	0.971135719981138	0.741922326657146	0.85958233548507	1.04594586703529	1.10480893059411	0.873275009065367	0.80499782875148	0.866436791009998	0.716212064140619	0.705403484327025	0.660101937015479	0.704476513684033	0.807038505484947	0.780212940000796	0.706330454970017	0.688103183489924	0.75424440326259	0.653885660446595	p.Ala72Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.319	-2.981	0.662	13.911	13.911	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.715	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A72P	72	A	P	missense	possibly_wt-like	0.774668647820347	0.347150084862034	8	0.122736089547715	0.534110332703543	1.01522696293715	0.731478471526702	0.90824126152797	1.08344880135231	1.12309680858565	0.677699592238207	0.0322733666106599	0.674999742627137	0.966111138094138	0.691020227829793	0.655132995978042	0.726907459681544	0.825431911965513	0.788233117079383	0.633275638632419	0.307248399218513	0.651137673849566	0.779396984777258	p.Ala72Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.319	-3.583	1.264	13.013	13.013	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.06	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A72Q	72	A	Q	missense	possibly_low	0.65962471433178	0.370441734157342	4	0.185220867078671	0.296598485672304	1.02265094299126	NA	0.151629962269364	NA	NA	0.819856813840904	0.649823147930598	NA	1.01718893328625	0.648999279753432	NA	0.37812238415781	NA	NA	0.686376738370461	0.611621821136403	NA	0.805050708166587	p.Ala72Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.319	-3.425	1.106	8.387	8.387	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.265	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A72R	72	A	R	missense	wt-like	0.854164381075435	0.175704071190098	8	0.0621207701103012	0.732409908967352	0.975918853183517	1.05781698013874	0.700436246880656	0.676729228614803	0.604447048238241	1.04212257385848	0.996818870896838	0.863513828890676	0.89143027108505	0.747279389803448	0.810397195575304	0.631112845195882	0.625955296036649	0.560778465332615	0.769401407521852	0.782646536527548	0.752670115177461	0.741888664429436	p.Ala72Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.319	-3.378	1.059	10.671	10.671	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A72S	72	A	S	missense	possibly_wt-like	0.774470265240786	0.446840823699009	4	0.223420411849505	0.336574304604651	1.21236622587692	1.22924279071815	NA	0.379826838749025	0.401892265722005	NA	NA	NA	1.08691916577396	0.660205684899598	0.891957570975461	NA	0.480338787853895	0.47194775328136	NA	NA	NA	0.8400725819453	p.Ala72Ser	1	0	NA	NA	NA	NA	NA	NA	NA	1.304	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.319	-1.601	-0.718	12.06	12.06	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	-1.13	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
A72T	72	A	T	missense	wt-like	1.0364908879939	0.0827370532022238	4	0.0413685266011119	0.955410065762237	1.11757171022557	NA	NA	NA	NA	1.10469561892143	0.917233004284045	1.04862493726349	1.07540999150666	0.813533464187266	NA	NA	NA	NA	0.792774806842267	0.743420836365432	0.852369735097266	0.834292121532266	p.Ala72Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.319	-2.883	0.564	7.017	7.017	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.46	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A72V	72	A	V	missense	possibly_wt-like	0.795865362008568	0.172161643647366	8	0.0608683328416371	0.676565621839963	0.915165102177173	0.975129536158032	0.94488225569771	0.792671594653727	0.873015496299829	0.461473783889865	0.626692152745709	0.818222853015383	0.874835223608291	0.705548104881465	0.771056451324768	0.743798341342022	0.68281951494936	0.678559572149478	0.552507119906486	0.600221185317631	0.72827669481357	0.733553834078981	p.Ala72Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.319	-3.198	0.879	21.979	21.979	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.325	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
A72W	72	A	W	missense	possibly_low	0.507776927610116	0.259679786829046	6	0.106013829040978	0.299993640826612	0.71556021439362	0.564439202834823	0.726374444178761	0.710574377493035	0.541941713752082	0.0142920213159891	NA	NA	0.489039806086008	0.557724234724571	0.575659634206969	0.643069917621887	0.642554732642066	0.533366654560078	0.385467815763121	NA	NA	0.539788835242174	p.Ala72Trp	0	0	NA	NA	NA	NA	NA	NA	NA	1.888	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.319	-5.738	3.419	0.398	NA	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A72X	72	A	X	nonsense	low	0.268730932676681	0.328101722374107	5	0.146731550952654	-0.0188576225862241	0.556319487939585	NA	0.48320407298132	0.0725696865917196	0.0577691158319307	0.741262694839178	NA	NA	-0.0111509068607444	0.329643761008371	NA	0.53097246894997	0.329643761008371	0.321032015532212	0.657018861894807	NA	NA	0.288569021552418	p.Ala72Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A72Y	72	A	Y	missense	low	0.271274482238869	0.254096335332151	2	0.179673241788015	-0.0808786006511969	0.623427565128936	NA	NA	0.450947724026884	NA	0.0916012404508543	NA	NA	NA	0.464782967347825	NA	NA	0.515220201161852	NA	0.414345733533798	NA	NA	NA	p.Ala72Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	86.7	23.7	0.866	78.2	54.6	-69.4	-35.4	30.5785123966942	-2.5	0	0	53.63	0	0	0	0	6	10.817792651923	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.319	-4.63	2.311	1.734	NA	81.64	0.003101657	0	0.088650526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73A	73	E	A	missense	possibly_low	0.62728781392729	0.166780929108826	7	0.0630372659786065	0.503737042925349	0.750838584929231	NA	0.591032326656969	0.76393953214654	0.877213497779986	0.571902532865442	0.437196388998679	0.433894056634528	0.715836362408887	0.593756434905676	NA	0.58067947919249	0.668727804144754	0.680400612168588	0.593756434905676	0.506823898499151	0.521279744386174	0.653696964981834	p.Glu73Ala	1	0	NA	NA	NA	NA	NA	NA	NA	-0.678	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.059	-3.368	2.309	2.847	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E73C	73	E	C	missense	possibly_low	0.618315686986645	0.167383708624521	8	0.0591790777142758	0.502326826028367	0.734304547944922	0.594371053149292	0.515314628005062	0.679281861324199	0.789980995924001	0.491467833361705	0.357996120362954	0.877968478470018	0.640144525295928	0.602790696308153	0.589900505752613	0.545774894409436	0.627207241034409	0.642144664036342	0.56371103198774	0.467788249049244	0.760455293937409	0.615680886863692	p.Glu73Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.059	-3.74	2.681	11.873	11.873	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73D	73	E	D	missense	wt-like	0.956420692071539	0.109979423167749	6	0.0448989114944353	0.868420442597394	1.04442094154568	1.01308784126868	0.75391765795973	0.924633392738375	NA	1.05929822938889	NA	1.02437984441118	0.963207186662373	0.776877822694887	0.789116121592122	0.655766875634773	0.747540503754102	NA	0.775817164576642	NA	0.839311488277055	0.777938480813132	p.Glu73Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.059	-2.71	1.651	9.746	9.746	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E73E	73	E	E	synonymous	wt-like	1.02062265104422	0.314847351508609	5	0.140804016101804	0.744651850606087	1.29659345148236	NA	1.00574119881442	1.1969143385102	1.36057385330731	0.520977339538822	NA	NA	1.01890652505036	0.805913365292768	NA	0.771853289889651	0.881081364054737	0.892379041043247	0.574733948819295	NA	NA	0.805913365292768	p.Glu73=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E73F	73	E	F	missense	possibly_low	0.603373523840461	0.145165727271844	7	0.0548674876073036	0.495835224207948	0.710911823472973	0.738779772778633	0.542913310249471	0.586309124598542	0.689048313015793	0.382854182310468	0.79223192853253	NA	0.491478035397786	0.581608533377306	0.658606783670831	0.558497422450458	0.581608533377306	0.597880480388835	0.523139724724127	0.681811219908949	NA	0.541013431176451	p.Glu73Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.059	-4.57	3.511	0.951	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73G	73	E	G	missense	wt-like	0.827452574838125	0.0658851809103602	8	0.0232939291007091	0.781797312742305	0.873107836933944	0.901200109442131	0.862482166923894	0.869790090672858	0.874243408112696	0.810317053422125	0.722512562538214	0.736824898478871	0.842250309114208	0.695124790740019	0.735882566040592	0.705813287174446	0.720642471213499	0.679098074767477	0.68281327698761	0.647448448447385	0.684436294305592	0.717188124087937	p.Glu73Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.059	-2.503	1.444	14.423	14.423	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.66	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E73H	73	E	H	missense	possibly_low	0.641547223923506	0.289219126534451	7	0.109314554744783	0.427294633637699	0.855799814209312	NA	0.884997036297539	0.899141751107867	0.80724954101171	0.34578018194587	0.163589521104837	0.811574555645458	0.578497980351259	0.649717811098952	NA	0.716192263040375	0.735038065347463	0.649717811098952	0.509291183166732	0.371970545522349	0.724695965776173	0.584719029446588	p.Glu73His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.059	-3.53	2.471	10.893	10.893	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73I	73	E	I	missense	possibly_low	0.704172959515405	0.262054476033031	3	0.151297222280017	0.407635852885621	1.00071006614519	NA	0.4015786772542	0.855741515579417	0.855198685712597	NA	NA	NA	NA	0.670745982407062	NA	0.493344535239179	0.713752312966626	0.670745982407062	NA	NA	NA	NA	p.Glu73Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.059	-4.313	3.254	1.09	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73K	73	E	K	missense	possibly_wt-like	0.770420175896847	0.220602887107126	3	0.127365136255308	0.520789095950407	1.02005125584329	NA	0.599557352306408	0.692236015584683	1.01946715979945	NA	NA	NA	NA	0.633560637888928	NA	0.584609372544459	0.633560637888928	0.742786174889501	NA	NA	NA	NA	p.Glu73Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.059	-2.969	1.91	6.394	6.394	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E73L	73	E	L	missense	low	0.462357321151058	0.14171571171593	8	0.050104070377506	0.364155147732287	0.56055949456983	0.405788683819465	0.366572848632519	0.569475573905707	0.721071687047312	0.507819061960124	0.294453818794649	0.329091681666219	0.504585213382474	0.523886964203069	0.500177442554576	0.477207437377242	0.573352476990168	0.611924380424991	0.56981883439732	0.43646998394753	0.464833877669253	0.547596485851563	p.Glu73Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.059	-3.867	2.808	1.561	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73M	73	E	M	missense	possibly_wt-like	0.723695951943314	0.149161683835273	5	0.0667071329388005	0.59295237387134	0.854439530015289	0.642256193130884	0.584083985796521	0.758718356441529	0.667809850861013	0.965611373486626	NA	NA	NA	0.612683130958159	0.612683130958159	0.577476410993336	0.666167065663949	0.588566320077998	0.740821579946311	NA	NA	NA	p.Glu73Met	0	0	NA	NA	NA	NA	NA	NA	NA	0.198	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.059	-4.983	3.924	0.638	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73N	73	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu73Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.059	-2.764	1.705	9.745	9.745	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E73P	73	E	P	missense	low	0.495279588250751	0.183363038313741	8	0.0648286239053074	0.368217820229056	0.622341356272446	0.490608014811342	0.614326642859691	0.572480140302541	0.547419292321707	0.530210903657644	0.423342763024143	0.695833889685944	0.0880150593429962	0.557679281281817	0.54053248858589	0.591417766928876	0.574826073977744	0.535768855083868	0.578183034301435	0.499995824599056	0.6623588078019	0.338374935395365	p.Glu73Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.059	-4.032	2.973	0.759	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73Q	73	E	Q	missense	possibly_low	0.679381029134015	0.167680427650484	7	0.063377244470877	0.555163912531706	0.803598145736324	0.599845557908104	0.542093073009533	0.921951210394185	0.88865390576557	0.526608138025269	NA	0.554087499144852	0.722427819690595	0.592505146569241	0.592505146569241	0.558119306887078	0.746225020818963	0.685417820722698	0.576837265053691	NA	0.58601513839072	0.657007511594144	p.Glu73Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.059	-2.958	1.899	6.317	6.317	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E73R	73	E	R	missense	low	0.573977478787279	0.125337935950948	8	0.0443136522254201	0.487124316402022	0.660830641172535	0.488321308195737	0.633748540780245	0.641123661908755	0.820751030980712	0.514114561437838	0.584776075168623	0.428051355196409	0.480933296629909	0.575866168502333	0.539444527272664	0.600370935008275	0.608492458172843	0.655638910333443	0.572170441596012	0.579561895408655	0.518132903994984	0.535717356619074	p.Glu73Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.059	-3.208	2.149	10.671	10.671	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73S	73	E	S	missense	low	0.514915899885116	0.181550377675521	6	0.0741176313191002	0.369648011880262	0.66018378788997	NA	0.777988431327152	0.61537997882101	0.43192262019082	0.282707608867538	0.382291482407485	NA	0.599205277696691	0.540425210269978	NA	0.666863097056655	0.595866405412891	0.485117611516638	0.485731191236615	0.479762769494256	NA	0.595119229303341	p.Glu73Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.059	-2.825	1.766	5.73	5.73	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E73T	73	E	T	missense	possibly_low	0.696357739187066	0.217756382523631	5	0.0973836147714572	0.505489361550688	0.887226116823445	NA	0.770676875753865	0.824606963064976	NA	0.528063404004758	NA	0.942649875830858	0.415791577280875	0.663492592987625	NA	0.663492592987625	0.698482295022226	NA	0.57738086194628	NA	0.795292267198732	0.503000054648622	p.Glu73Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.059	-3.717	2.658	2.14	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73V	73	E	V	missense	possibly_low	0.655124737092992	0.179867319032186	8	0.0635927005007516	0.530485334431876	0.779764139754107	0.42618898356535	0.754331552042545	0.839746593965388	0.861603554178597	0.406876990502538	0.73629841200119	0.694090160743004	0.521861649745321	0.655100395498603	0.509883426151365	0.655957673841296	0.705907564276173	0.673554847344052	0.532113152309537	0.65424311715591	0.661419646914245	0.556273542446093	p.Glu73Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.059	-3.894	2.835	1.354	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E73W	73	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu73Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.059	-5.613	4.554	0.196	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E73X	73	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu73Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E73Y	73	E	Y	missense	possibly_low	0.584041802959562	0.349226051573968	6	0.142570938540517	0.304607898178075	0.86347570774105	1.14759068472572	0.639230395430885	0.464522731454236	0.601358732849887	0.06009388411453	0.591454389182119	NA	NA	0.571138766930181	0.853109416228827	0.602897977745024	0.521878096980809	0.559424079859321	0.402576544093862	0.582853454001041	NA	NA	p.Glu73Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	87	20	0.832	110.4	6.5	-63	-116.1	37.3831775700935	-0.4	0	0	69.26	0	0	2	52	4	10.9209806272148	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.059	-4.446	3.387	1.786	NA	19.11	0.002097291	0	0.059944075	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74A	74	R	A	missense	possibly_wt-like	0.886305799127703	0.386659677367426	8	0.136704839938955	0.618369236335039	1.15424236192037	0.441105790107859	1.22832618651451	0.979753908983558	0.863262225765486	1.28193317422953	0.183258782580666	1.13835754113497	0.974448783705045	0.779079523878361	0.516980492440662	0.874461223212217	0.774574496671717	0.674282260324838	0.85897973822483	0.38166498733593	0.900699122669098	0.783584551085004	p.Arg74Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.475	-3.512	2.037	2.982	NA	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74C	74	R	C	missense	wt-like	1.1859124833428	0.227633514973236	5	0.101800802687474	0.986386576478084	1.38543839020752	1.45632930033303	0.869798491779273	1.31065136748114	1.05826906379572	NA	NA	NA	1.23451419332485	0.914201897750522	1	0.709185989802255	0.936863969972179	0.759802809688814	NA	NA	NA	0.914201897750522	p.Arg74Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.475	-4.003	2.528	10.793	10.793	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74D	74	R	D	missense	possibly_wt-like	0.889008686630251	0.181374734397381	2	0.128251304628297	0.637640748588513	1.14037662467199	NA	NA	NA	NA	1.01725999125855	NA	NA	0.760757382001953	0.718186376108902	NA	NA	NA	NA	0.760114292428438	NA	NA	0.676258459789366	p.Arg74Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.475	-3.366	1.891	7.58	7.58	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74E	74	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.475	-2.665	1.19	7.15	7.15	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.265	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74F	74	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.475	-3.259	1.784	11.382	11.382	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74G	74	R	G	missense	wt-like	1.05168266862646	0.147447525286809	8	0.0521305724997387	0.949508624033518	1.1538567132194	1.18514968850232	1.0469451168127	0.886366107432634	0.783235244301059	1.14165665332281	1.03602589087526	1.16669284707218	1.16738980069271	0.804275878634858	0.870979108297495	0.790847602643092	0.728772219449034	0.639186304265504	0.806581151339166	0.80197060593055	0.915960331232345	0.880488801976033	p.Arg74Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.475	-3.265	1.79	15.561	15.561	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	1.945	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R74H	74	R	H	missense	wt-like	1.25013708799303	0.137898352071872	2	0.0975088598644707	1.0590232344851	1.44125094150095	NA	NA	NA	NA	1.3476459478575	NA	NA	1.15262822812856	0.878300387885334	NA	NA	NA	NA	0.883525944932741	NA	NA	0.873074830837928	p.Arg74His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.475	-3.795	2.32	10.981	10.981	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.26	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74I	74	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.475	-3.598	2.123	6.67	6.67	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R74K	74	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.475	-1.823	0.348	10.313	10.313	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.53	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
R74L	74	R	L	missense	possibly_low	0.657144775647071	0.687516821935646	6	0.280677567220376	0.107026852626815	1.20726269866733	NA	0.988885212823856	1.10128999924235	1.25387456807933	-0.348369550675429	-0.0838791416981843	NA	1.03106756611051	0.78805209428136	NA	0.764082964026813	0.834182171401684	0.845585905060878	0.25	0.25	NA	0.812021224535906	p.Arg74Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.475	-3.74	2.265	4.117	NA	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74M	74	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.475	-4.914	3.439	0.907	NA	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74N	74	R	N	missense	wt-like	1.15812692344453	0.0692671850513912	2	0.0489792962635421	1.06212926677987	1.25412458010919	1.20710621970807	NA	1.10914762718099	NA	NA	NA	NA	NA	0.859730737326547	0.881425510280796	NA	0.838035964372299	NA	NA	NA	NA	NA	p.Arg74Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.475	-2.905	1.43	8.802	8.802	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74P	74	R	P	missense	wt-like	1.05939478126819	0.0905475428895975	2	0.0640267815970141	0.933904595292033	1.18488496724435	NA	0.995367999671179	1.12342156286521	NA	NA	NA	NA	NA	0.806054035468409	NA	0.767071419660985	0.845036651275833	NA	NA	NA	NA	NA	p.Arg74Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.475	-4.248	2.773	1.01	NA	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74Q	74	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.475	-3.097	1.622	6.317	6.317	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74R	74	R	R	synonymous	wt-like	1.15674091123496	0.0369989642931972	5	0.0165464398513353	1.12431048505399	1.18917133741594	1.20307369559536	1.14132876441787	1.15696412347798	NA	1.10506903658065	NA	NA	1.17726893610296	0.86148768272138	0.879506929996236	0.834356875753909	0.86148768272138	NA	0.792914292463487	NA	NA	0.885450578540328	p.Arg74=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R74S	74	R	S	missense	possibly_wt-like	0.86874148539114	0.534848251288298	5	0.239191409505505	0.399934937348979	1.3375480334333	-0.051012707953834	NA	NA	NA	1.18182908104391	1.29826962945802	0.950398893507572	0.964222530900027	0.799465836920784	0.282842066566463	NA	NA	NA	0.82158707272035	0.931223382797171	0.799465836920784	0.778448435483645	p.Arg74Ser	1	0	NA	NA	NA	NA	NA	NA	NA	-3.187	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.475	-3.262	1.787	6.003	6.003	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R74T	74	R	T	missense	wt-like	1.03681904855797	0.145954867510599	6	0.0595858251460818	0.92003297728255	1.15360511983339	1.07592890164646	0.806284468447664	1.03201909969023	1.12081362164723	0.954257465823023	1.23161073409323	NA	NA	0.793719955038439	0.819014422540106	0.679907093959385	0.800208088148203	0.787231821928675	0.736580465942645	0.898369033727394	NA	NA	p.Arg74Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.475	-3.159	1.684	5.553	5.553	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	3	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R74V	74	R	V	missense	possibly_wt-like	0.855027325935757	0.318441968408353	6	0.130003389214658	0.600225365206885	1.10982928666463	0.679403471306706	1.11998660908494	1.08717675103071	0.995354382770702	0.288145837815407	NA	NA	0.960096903606075	0.754293913276134	0.63035693365376	0.824518501324494	0.827260294064743	0.732211479360774	0.487762575463905	NA	NA	0.776376347191493	p.Arg74Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.475	-3.414	1.939	5.612	5.612	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R74W	74	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.475	-5.613	4.138	0.846	NA	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R74X	74	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R74Y	74	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg74Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.6	90.2	18.1	0.065	64.2	-173.7	-65.7	176.9	51.3207547169811	-0.3	0	0	77.48	0	0	1	1	3	12.7909365513241	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.475	-3.415	1.94	9.766	9.766	28.04	0.00245553	0	0.070183129	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H75A	75	H	A	missense	wt-like	0.863775577437188	0.223172576183795	8	0.0789034209972163	0.709127714025643	1.01842344084873	1.01153461646284	0.545050895353871	0.852013024268579	0.551215924105791	0.821540823621046	1.17852475781481	1.00454868219803	0.945775895672536	0.740553657002758	0.788377133700994	0.559482813208972	0.711923665222431	0.537433873804172	0.687005779725427	0.872204405798647	0.828630555335758	0.769183648783084	p.His75Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.986	-2.468	-0.518	10.206	10.206	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.03	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H75C	75	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.986	-3.627	0.641	26.383	26.383	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.145	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H75D	75	H	D	missense	wt-like	1.04565484349853	0.196525266615611	4	0.0982626333078057	0.853063621189168	1.2382460658079	1.19340910853104	0.881482249243406	0.870905273762415	1.23682274245727	NA	NA	NA	NA	0.779648608079832	0.874908746406557	0.714572005360735	0.721189415505726	0.838107800653938	NA	NA	NA	NA	p.His75Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.986	-2.765	-0.221	15.554	15.554	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.235	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H75E	75	H	E	missense	wt-like	1.10165020129634	0.359727709976024	8	0.127182951552377	0.852376196806174	1.3509242057865	1.25652473840698	1.11656232643396	1.11328477724494	1.20225945813747	1.65945922740996	1.0794222794568	1.02860677583013	0.357082027450444	0.831712270257259	0.904937681074559	0.822939964651557	0.840065039808214	0.822950019046331	1	0.823359500706305	0.841588085611492	0.473513297320962	p.His75Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.986	-3.038	0.052	12.31	12.31	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.06	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H75F	75	H	F	missense	possibly_wt-like	0.963100916795141	0.244492855368085	3	0.141158015861704	0.686436289577068	1.23976554401321	1.12325613582224	0.681679110221369	NA	1.08436750434182	NA	NA	NA	NA	0.771248321013393	0.841531609263512	0.622466120870288	NA	0.771248321013393	NA	NA	NA	NA	p.His75Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.986	-3.599	0.613	15.303	15.303	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
H75G	75	H	G	missense	wt-like	1.06625835617534	0.135246446070566	8	0.047816839573939	0.972539072755887	1.15997763959479	0.905131748591909	1.09190987833415	1.09360569607466	1.23699404506295	1.08098626418279	1.12925725767321	0.826547213699086	1.16563474578393	0.820994493479569	0.737753147628685	0.811575600967375	0.830413385991764	0.838182925675673	0.783918465978913	0.847921800475096	0.732760140477831	0.87960732905823	p.His75Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.986	-2.569	-0.417	15.561	15.561	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.485	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H75I	75	H	I	missense	possibly_wt-like	0.901571660586517	0.329193029629343	8	0.116387311785126	0.673456721230236	1.1296865999428	1.21278675448687	1.12822461601277	0.899867592597442	1.06637410725699	0.794469786945979	0.161585159715556	0.892594338783079	1.05667092889346	0.765844987328814	0.884128175343116	0.828316083876197	0.73539405609329	0.763357288990299	0.676893723494387	0.370982650532715	0.768332685667329	0.82488046374543	p.His75Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.986	-3.79	0.804	9.904	9.904	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.04	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
H75K	75	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.986	-2.65	-0.336	14.232	14.232	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	-0.57	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H75L	75	H	L	missense	wt-like	0.940508680923711	0.144926504210966	7	0.0547770697891674	0.833147596958306	1.04786976488912	NA	1.0649540101	1.01298751894824	0.95441959464067	0.9929096773475	0.692986281338889	0.789557202480313	1.07574648161037	0.751018529068227	NA	0.799149399366807	0.790874002511167	0.714259464937384	0.751018529068227	0.632895750807464	0.71283756483254	0.834461123033042	p.His75Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.986	-2.911	-0.075	10.902	10.902	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.1	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
H75M	75	H	M	missense	wt-like	1.10083609617213	0.140451714373028	8	0.049657179831222	1.00350981212911	1.19816238021515	1.01436594238893	0.970919853179063	1.1136761670518	1.18846708095065	1.38857865836615	0.98998735272448	1.00347010317071	1.13722361154526	0.82247549528604	0.789724212093865	0.755801235579643	0.840256997902721	0.816901350774145	0.898815860694764	0.779279467789267	0.828049639797934	0.865337892090665	p.His75Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.986	-3.962	0.976	7.677	7.677	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.385	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H75N	75	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.986	-2.992	0.006	24.992	24.992	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-0.45	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H75P	75	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.986	-3.19	0.204	15.345	15.345	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	-0.06	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
H75Q	75	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.986	-3.085	0.099	12.528	12.528	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
H75R	75	H	R	missense	wt-like	0.986600213205423	0.204032220453548	8	0.0721362833316263	0.845215695896859	1.12798473051399	0.959490256088786	0.936569144806277	1.02050117129915	0.964637192008807	0.581367291085347	1.31994142227552	1.0250914425763	1.0852037855032	0.779087370451877	0.763615649095952	0.739966137127061	0.794559091807802	0.718740408010609	0.597291880130093	0.941904817619898	0.839694750347175	0.83921103553735	p.His75Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.986	-2.973	-0.013	10.159	10.159	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	-0.115	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
H75S	75	H	S	missense	wt-like	1.0023068552835	0.144680756143676	8	0.0511523718881952	0.902050048658842	1.10256366190817	0.809754653469396	1.08773119382142	1.0940307420398	1.14100095076067	0.796224765753047	1.12665031375232	0.892901910544608	1.07016031212676	0.802867151978323	0.692374965332357	0.809649297732425	0.830621850831972	0.796085006224222	0.677549274465499	0.846636909012172	0.768498341785927	0.831655480264022	p.His75Ser	0	0	NA	NA	NA	NA	NA	NA	NA	0.511	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.986	-2.301	-0.685	12.06	12.06	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.39	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H75T	75	H	T	missense	wt-like	1.02988622549826	0.107422870030168	8	0.0379797199264264	0.955447342299546	1.10432510869697	0.846124970854281	1.10201746341308	0.965629297110704	0.9225704465159	1.07409043584883	1.11869317882218	1.15518921634807	1.05477479507303	0.798788820412981	0.709679108327555	0.816235027582563	0.767647045999152	0.70029197194115	0.7813426132434	0.842715054514592	0.909764551730113	0.823928134218374	p.His75Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.986	-2.569	-0.417	12.265	12.265	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.97	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H75V	75	H	V	missense	wt-like	1.08421894619509	0.089223975756984	8	0.0315454391510938	1.02239102158245	1.14604687080774	1.13694425238507	1.03890239705106	1.0434532486408	0.970548469870014	1.24590167614058	0.997485823857053	1.1153327538328	1.12518294778337	0.825668302679239	0.848044093711522	0.787140044188403	0.805815994655709	0.721332808027141	0.845520610702769	0.782975259427142	0.888298124355496	0.859290492111681	p.His75Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.986	-3.202	0.216	8.284	8.284	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.41	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
H75W	75	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.986	-5.787	2.801	1.023	NA	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H75X	75	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His75Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H75Y	75	H	Y	missense	possibly_wt-like	0.75298418059899	0.499059255820471	5	0.223186084163006	0.315547493788973	1.19042086740901	0.524818041449558	1.1715388063883	1.11335890959773	NA	-0.0160839655749362	NA	NA	0.971289111134293	0.781997611675697	0.556808815969914	0.848283196680597	0.84010139820318	NA	0.374121235608055	NA	NA	0.781997611675697	p.His75Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	93.2	19.3	0.967	13	-138.6	-163.7	172.2	32.4074074074074	-0.4	0	0	78.94	2	12	0	0	3	14.6947241505242	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.986	-3.755	0.769	11.814	11.814	78.91	0.003296644	0	0.094223581	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.04	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
Y76A	76	Y	A	missense	possibly_wt-like	0.799679924030373	0.150004585832959	8	0.0530346299257826	0.695733959442429	0.903625888618317	0.976630464857317	0.811435985353259	0.816615631149116	1.01491200968073	0.701739411381392	0.583686232152192	0.839709939906635	0.652709717762341	0.688422391580932	0.77177055795637	0.682281856555107	0.694562926606758	0.74078850678451	0.642255420451555	0.579024741549486	0.739849497845613	0.621991730365347	p.Tyr76Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-0.735	-3.509	2.774	1.27	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y76C	76	Y	C	missense	wt-like	0.938350221804623	0.179269159743149	3	0.103501097635105	0.735491798079453	1.14120864552979	NA	0.965072356875883	NA	1.10275832273738	0.747219985800612	NA	NA	NA	0.753105638194661	NA	0.753105638194661	NA	0.779313642764815	0.659244135419044	NA	NA	NA	p.Tyr76Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-0.735	-5.068	4.333	0.436	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y76D	76	Y	D	missense	possibly_wt-like	0.848791723090902	0.328675841450903	6	0.134181350389103	0.585801108931311	1.11178233725049	1.26876676887056	NA	1.12997872386029	NA	0.774029473843766	0.332522968692123	0.73668835761644	0.850764045662232	0.702913443012964	0.910762151712297	NA	0.848252627031796	NA	0.669258493342303	0.455233228262884	0.684362754299228	0.7214641317267	p.Tyr76Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-0.735	-4.143	3.408	0.561	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y76E	76	Y	E	missense	possibly_low	0.606937994177012	0.16440702842531	8	0.058126662337133	0.49301182945471	0.720864158899314	0.2778962512752	0.617915467147118	0.664007793763831	0.454924202526509	0.703293775165519	0.691440319383616	0.648576381884424	0.797449762269878	0.625924912684758	0.439329226210181	0.59307215452705	0.619716036989558	0.495204990900144	0.64283603412281	0.632133788379957	0.63690622633564	0.694687136484375	p.Tyr76Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-0.735	-3.919	3.184	0.628	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76F	76	Y	F	missense	possibly_wt-like	0.892660402542916	0.301171567796564	7	0.113832152907591	0.669553482561381	1.11576732252445	1.07367829550592	1.13966618200672	0.837693152004996	1.19643188232062	0.864182247018319	0.300009893452896	NA	0.836961165490933	0.714531661980135	0.817943636985238	0.8335904532429	0.704900448610437	0.820394326690354	0.702933964387892	0.439208421410089	NA	0.714531661980135	p.Tyr76Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-0.735	-2.558	1.823	13.486	13.486	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.415	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y76G	76	Y	G	missense	possibly_low	0.679611701310015	0.0680876297886194	8	0.024072612369226	0.632430248052538	0.726793154567491	0.675823974330315	0.751141070121607	0.653168264268724	0.762318514909748	0.644685239786155	0.547649857544658	0.690382511079896	0.711724178439013	0.629333566698505	0.628653893043065	0.654486915370147	0.614399763058133	0.630013240353944	0.620943529137181	0.561263396659418	0.659422731302551	0.65163162857308	p.Tyr76Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-0.735	-3.823	3.088	0.884	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y76H	76	Y	H	missense	wt-like	0.929350288440732	0.184272159300397	4	0.0921360796501985	0.748766890649629	1.10993368623183	NA	0.767611549154754	1.0780218214685	1.0994697491819	NA	0.772298033957769	NA	NA	0.724928890715866	NA	0.66207952901353	0.822770236318455	0.777871433763692	NA	0.671986347668039	NA	NA	p.Tyr76His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-0.735	-4.094	3.359	0.598	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.14	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y76I	76	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr76Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-0.735	-2.806	2.071	7.344	7.344	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76K	76	Y	K	missense	possibly_wt-like	0.832973393422658	0.297852093155754	6	0.12159760784192	0.59464646144627	1.07130032539905	1.42094569243868	0.635849156625105	0.645305435838488	0.788502132626618	0.685726578902172	0.821511364104882	NA	NA	0.638885064025629	0.983165310211335	0.601339283560318	0.610543419493607	0.641496106258041	0.636274021793216	0.696242254080694	NA	NA	p.Tyr76Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-0.735	-3.936	3.201	0.7	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76L	76	Y	L	missense	wt-like	0.957226813703494	0.133479126883604	8	0.047191997883128	0.864732197494073	1.04972142991292	1.0294954676111	1.08464371031504	0.902363057526986	0.918209930324689	0.972708535829924	0.667207576170126	1.04997108180667	1.03321515004342	0.770197561743181	0.796922484936065	0.808226019796969	0.736617963012655	0.698379660845039	0.743472638550297	0.620190131046644	0.853094759654095	0.813099844393383	p.Tyr76Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-0.735	-3.272	2.537	4.533	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y76M	76	Y	M	missense	possibly_wt-like	0.769214933498656	0.20526808753492	6	0.0838003458229179	0.604969273793735	0.933460593203576	NA	0.702474065830303	0.823474862111978	0.557178120936536	1.15060876582549	NA	0.7073681252123	0.674185661075326	0.650674526007105	NA	0.632052245436075	0.697927053322217	0.540048604413272	0.809925103996034	NA	0.668571070848411	0.632777981165797	p.Tyr76Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-0.735	-4.646	3.911	0.999	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76N	76	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr76Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-0.735	-4.152	3.417	0.553	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y76P	76	Y	P	missense	possibly_low	0.665003941627846	0.363202531206808	5	0.162429109875682	0.34664873623061	0.983359147025083	NA	0.914247099557928	0.876177474373813	0.849859789389209	0.0435467451713919	NA	NA	0.641188599646889	0.668404601196099	NA	0.729676049937749	0.723775179277509	0.668404601196099	0.396395561759707	NA	NA	0.61620527117779	p.Tyr76Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-0.735	-4.344	3.609	0.401	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76Q	76	Y	Q	missense	possibly_low	0.626291307147958	0.341348599081768	6	0.139354982027366	0.353160561308094	0.899422052987823	0.562433047364814	0.932357280352014	0.719599058637949	0.798677545669163	NA	-0.0260529752903685	NA	0.770733886154179	0.646469729530819	0.574705152541157	0.738024538497467	0.646980909731375	0.645958549330263	NA	0.278500938188855	NA	0.681269139615131	p.Tyr76Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-0.735	-4.178	3.443	0.4	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76R	76	Y	R	missense	low	0.561350013677916	0.103590946035823	8	0.0366249302057302	0.489566469538392	0.633133557817441	0.706691605212166	0.399092458508046	0.554173016879876	0.596031874606786	0.677841659761919	0.472789789293222	0.495957266793468	0.588222438367847	0.561467639091925	0.643339987009474	0.492198430239167	0.565847300216831	0.557087977967019	0.633328706226602	0.524366913447983	0.55470657931921	0.589603119590463	p.Tyr76Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-0.735	-4.187	3.452	0.688	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76S	76	Y	S	missense	low	0.611827177900484	0.0793736140530306	3	0.0458263774400707	0.522009128576007	0.701645227224961	NA	NA	NA	NA	0.694093001240919	0.605685998688516	0.535702533772017	NA	0.589867825661254	NA	NA	NA	NA	0.639399197018587	0.589867825661254	0.576113117512433	NA	p.Tyr76Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-0.735	-3.835	3.1	0.881	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.305	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y76T	76	Y	T	missense	wt-like	0.825326416417641	0.0703811716885417	7	0.0266015824670316	0.773188272850487	0.877464559984795	NA	0.78804513874063	0.835041411023555	0.840405612448238	0.725418822448374	0.800599658208488	0.830581075574079	0.957193196480124	0.685935445343394	NA	0.671499069924317	0.703599895716616	0.664258457327796	0.651100576220849	0.685935445343394	0.734932751831526	0.774917965929487	p.Tyr76Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-0.735	-3.853	3.118	1.073	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y76V	76	Y	V	missense	wt-like	0.938460683687622	0.107808460135524	8	0.0381160466155542	0.863754605088086	1.01316676228716	0.809992880179251	0.850728792276075	0.882894186571303	1.11155375148834	0.863867359409671	1.06587130937704	0.936289474623467	0.98648771557583	0.755120149456342	0.692488308007071	0.700395179265914	0.727069407313562	0.783170891599122	0.702816341954613	0.816680597631208	0.791866597132313	0.789631081225048	p.Tyr76Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-0.735	-3.427	2.692	4.768	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y76W	76	Y	W	missense	possibly_wt-like	0.920898505111415	0.324947661430259	5	0.145321012017529	0.636074555360145	1.20572245486268	0.594247885101794	1.05628874330707	1.18577608014154	1.21909954359035	NA	NA	NA	0.549080273416313	0.795154857207883	0.58984190528774	0.795154857207883	0.875618577811708	0.830335264475742	NA	NA	NA	0.569944043298127	p.Tyr76Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-0.735	-4.488	3.753	0.627	NA	26.8	0.000896752	0	0.025630656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y76X	76	Y	X	nonsense	low	0.0915319576710646	0.123712181551823	4	0.0618560907759113	-0.0297037524741618	0.212767667816291	NA	0.185878037430958	0.199627244310253	NA	0.0394899508389355	NA	NA	-0.0588674018958882	0.392934811738487	NA	0.393910170427304	0.39195945304967	NA	0.394880195617658	NA	NA	0.264603504635807	p.Tyr76Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	96.8	18.4	0.969	34.2	-98.1	-141.4	153.4	1.56862745098039	-1.4	0	0	69.01	1	47	0	0	4	17.4700795035398	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D77A	77	D	A	missense	possibly_wt-like	0.744645414392429	0.158902441468721	8	0.0561804969548157	0.634533663727428	0.854757165057429	0.669716355877835	0.918832251185807	0.812490916184307	0.92855636511913	0.531773543794874	0.515060051538657	0.781326727532773	0.799407103906046	0.694105078756899	0.625748031597221	0.731789727672122	0.692539949995838	0.702917105770134	0.578766739503649	0.545200771307199	0.708404685405463	0.695670207517959	p.Asp77Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.47	-2.802	1.332	8.122	8.122	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D77C	77	D	C	missense	possibly_low	0.659387970104545	0.319803513003939	8	0.113067616346183	0.437779514248235	0.880996425960856	0.887001557109082	0.855037871887295	0.973575588992273	0.957783468640598	0.0643238164725876	0.431314788696429	0.484702865452719	0.621363803585381	0.654314949161467	0.729127228238728	0.702381592446776	0.771544324418898	0.715734697064477	0.404156583837872	0.503925018336773	0.54864503311617	0.606248305876158	p.Asp77Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.47	-5.461	3.991	0.642	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77D	77	D	D	synonymous	wt-like	1.04171947475272	0.12702748374853	8	0.0449109975778248	0.953695536990419	1.12974341251502	1.11293488267855	0.927583423676564	1.03227905931241	1.21152738532873	1.1192588551755	0.871788798382433	1.15314061815106	0.905242775316521	0.799275156230373	0.836620999372539	0.735823870911987	0.800335585985008	0.827014482799848	0.798214726475737	0.721022628358539	0.908661190276521	0.748825967841522	p.Asp77=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D77E	77	D	E	missense	possibly_wt-like	0.796086116733744	0.116651803324404	6	0.0476228992867147	0.702746949292405	0.889425284175083	0.880517708226092	0.925757930137675	0.732930629542026	0.691028443056157	0.654785480164777	NA	NA	0.891496509275738	0.689780888348219	0.726042365188368	0.734982349112811	0.65351941150807	0.598748869469826	0.624716350986657	NA	NA	0.741921932432006	p.Asp77Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.47	-2.529	1.059	11.057	11.057	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D77F	77	D	F	missense	possibly_low	0.611606990450275	0.216938901275877	8	0.076699484097666	0.461278763986047	0.761935216914503	0.131004628727208	0.664280471784226	0.721074281894271	0.837843235908665	0.651235076712219	0.742545604200833	0.645697372648667	0.49917525172611	0.629372875988504	0.369441641384662	0.614445641362177	0.647704436609932	0.663134723147215	0.623390140993812	0.657322187580192	0.635355610983197	0.544879343121396	p.Asp77Phe	0	0	NA	NA	NA	NA	NA	NA	NA	2.521	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.47	-4.689	3.219	1.196	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77G	77	D	G	missense	possibly_low	0.634027256323441	0.136739258741195	8	0.0483446285551605	0.539273525509359	0.728780987137522	0.713638707651773	0.655256353422367	0.710282389684412	0.789808150112906	0.528696062343204	0.350485282429551	0.640189073493748	0.683862031449567	0.635013398418523	0.646645255224351	0.610285674669292	0.642411526502355	0.642068862239495	0.577617183767649	0.464086362152977	0.632388877452306	0.63763791938474	p.Asp77Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.47	-3.028	1.558	13.031	13.031	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D77H	77	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp77His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.47	-3.59	2.12	13.002	13.002	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.335	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D77I	77	D	I	missense	possibly_wt-like	0.720191914912936	0.294548948617868	4	0.147274474308934	0.431539249425355	1.00884458040052	0.287441819912849	0.831323665182481	0.81416113320315	0.947841041353263	NA	NA	NA	NA	0.69240442715043	0.443870783627137	0.691449742255497	0.693359112045363	0.711374430254283	NA	NA	NA	NA	p.Asp77Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.08	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.47	-4.338	2.868	5.011	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77K	77	D	K	missense	possibly_low	0.688589021921661	0.0720817668172984	2	0.0509695061164191	0.588690625623685	0.788487418219636	0.73955852803808	NA	NA	NA	NA	NA	NA	0.637619515805241	0.636695001445195	0.658977297137214	NA	NA	NA	NA	NA	NA	0.614412705753175	p.Asp77Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.47	-2.614	1.144	8.732	8.732	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.53	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77L	77	D	L	missense	possibly_low	0.672073166947379	0.0924872918065534	8	0.0326991956049965	0.607983921238155	0.736162412656602	0.666243391748201	0.842194226142629	0.620319642175508	0.707887284770772	0.620869370718355	0.522805141780589	0.679693532120265	0.716572746122712	0.6180715389781	0.6240956768135	0.696460887911379	0.59828907546821	0.606142340486727	0.6120474011427	0.549018114768905	0.653665717858172	0.654066812271284	p.Asp77Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.47	-3.448	1.978	8.2	8.2	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77M	77	D	M	missense	possibly_wt-like	0.761938898741481	0.264264285807631	7	0.0998825115204409	0.56617277347601	0.957705024006952	0.686377948484909	1.09356852527017	0.991290538180413	0.954254224878148	0.336433177891082	NA	0.61492458483996	0.656723291645684	0.633675226126471	0.633675226126471	0.812340209290583	0.780232664868358	0.714186941773161	0.505799723577346	NA	0.618781590788677	0.624007540049744	p.Asp77Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.47	-5.104	3.634	1.088	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77N	77	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp77Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.47	-2.085	0.615	13.439	13.439	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.53	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D77P	77	D	P	missense	wt-like	0.858894143332722	0.143833391025432	8	0.0508527830775698	0.759224519987057	0.958563766678387	0.831316004894041	0.737196324808114	0.898174883659569	1.09559729290063	0.957616279117843	0.684492337679489	0.956282510886753	0.710477512715337	0.718598606440888	0.702633350055082	0.648058622464541	0.734563862826694	0.776173162093285	0.737835109764175	0.628709317947487	0.802634714367493	0.651005493135678	p.Asp77Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.47	-2.847	1.377	16.573	16.573	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77Q	77	D	Q	missense	possibly_low	0.622646321731591	0.288149348962013	8	0.101876179322764	0.42297267937643	0.822319964086753	0.867370141237133	0.554333929919266	0.494396577308331	0.783051802805074	0.409951181081403	0.105017989024942	0.771312737849291	0.995736214627291	0.60143399581448	0.719787061534887	0.563762135914241	0.53652979823936	0.639105855714719	0.533261478780058	0.343102236949675	0.703011216725489	0.794276121903492	p.Asp77Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.47	-3.171	1.701	5.892	5.892	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.335	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77R	77	D	R	missense	low	0.540056667954685	0.0607833989248657	8	0.0214901767816698	0.497936695441214	0.582176640468157	0.590620816487315	0.559956002883725	0.60970521862432	0.599347217459468	0.509729471383239	0.484628863735435	0.437991978553186	0.528473774510794	0.562974143097907	0.588116231208679	0.566353816933848	0.593083205301265	0.558541926684692	0.570532444583096	0.530202069915231	0.523486858056135	0.559594469261966	p.Asp77Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.47	-3.155	1.685	9.732	9.732	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77S	77	D	S	missense	possibly_low	0.691568527868695	0.178727956412391	8	0.0631898749834077	0.567718648713627	0.815418407023762	0.867119374600826	0.875197778311095	0.811641920802281	0.626727839142348	0.664881185186442	0.758330910859982	0.337839407004769	0.590809807041815	0.646794906422125	0.719667752657619	0.711674970025814	0.692123558120213	0.570549740522912	0.628487478708747	0.665102334135502	0.469545344739396	0.590902620479617	p.Asp77Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.47	-2.825	1.355	7.749	7.749	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D77T	77	D	T	missense	wt-like	0.772188583258258	0.0654224385448871	8	0.0231303249684249	0.726853979369438	0.817523187147079	0.769988211620523	0.789627855958607	0.847491559939038	0.829320529474406	0.747747691142814	0.754730392673269	0.634978003359522	0.803624421897885	0.667778206488427	0.673455026062068	0.672228675925372	0.709706101908649	0.659397077105219	0.659441253326194	0.663327737051482	0.629582229508135	0.697788347284966	p.Asp77Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.47	-3.806	2.336	2.894	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.845	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D77V	77	D	V	missense	possibly_low	0.650028648150464	0.113073273994525	8	0.0399774394062465	0.571674306720088	0.728382989580839	0.645044559978009	0.697163818403387	0.776075081664626	0.828855995915248	0.565233511677098	0.489153361718882	0.62362109694731	0.575081758899149	0.618737622590428	0.614009770429988	0.629604310741389	0.674679714287685	0.659193355196909	0.591265303218627	0.532432071407158	0.623465474750868	0.583003238860102	p.Asp77Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.47	-3.492	2.022	8.217	8.217	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D77W	77	D	W	missense	possibly_low	0.626643860688175	0.15574167273498	8	0.0550629964521201	0.518722370761163	0.734565350615187	0.823719242013553	0.65182164517076	0.516939389532581	0.359618261524081	0.632308234316204	0.680726034616854	0.533413831036641	0.814604247294727	0.612511290685707	0.699018988657202	0.608702331969926	0.547585976002694	0.453408423587388	0.616320249401488	0.626853010025713	0.574880437340874	0.703302943256351	p.Asp77Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.47	-5.863	4.393	0.213	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D77X	77	D	X	nonsense	low	-0.0262115418733681	0.0293474572943227	8	0.0103758930316991	-0.0465479185229385	-0.0058751652237978	-0.0566188236767905	-0.0373669925932973	-0.0326113584546945	-0.056873721522134	-0.0122213024057885	-0.0415772093316489	0.000244240824384675	0.0273328321730239	0.283946813553562	0.28017480834347	0.290997968701522	0.278057458474411	0.270755222522294	0.375564086417088	0.270849467196995	0.287718818763653	0.3078974047069	p.Asp77Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D77Y	77	D	Y	missense	low	0.154944973852544	0.151122076145275	3	0.0872503713429695	-0.0160626116174221	0.325952559322509	NA	0.081061900503524	0.0549783277809674	0.32879469327314	NA	NA	NA	NA	0.345591695313115	NA	0.345591695313115	0.321016035763823	0.439890700225452	NA	NA	NA	NA	p.Asp77Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.7	98.9	18.7	0.655	34.9	-139.8	-76.1	106.8	67.9144385026738	-4.1	0	0	69.11	0	0	0	0	4	20.9731575557902	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.47	-4.638	3.168	2.131	NA	28.04	0.003037499	0	0.086816766	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T78A	78	T	A	missense	possibly_wt-like	0.953261032782613	0.421590959228541	6	0.172113788380072	0.615924206314924	1.2905978592503	NA	1.13124024345219	1.25225806000422	NA	1.03822965173689	1.0920383769494	1.1007122683237	0.105087596229273	0.829641933994336	NA	0.829706237374093	0.908224828536251	NA	0.767947253849459	0.829577630614578	0.880423627459473	0.346949583873971	p.Thr78Ala	1	0	NA	NA	NA	NA	NA	NA	NA	1.852	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.608	-2.439	-0.169	26.235	26.235	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.03	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
T78C	78	T	C	missense	wt-like	1.22093707628123	0.0861745966944364	3	0.0497529265988403	1.12342313202204	1.31845102054042	NA	1.29797315798261	1.12787416672117	1.23696390413991	NA	NA	NA	NA	0.847220441800791	NA	0.906567304931196	0.847220441800791	0.838169707327419	NA	NA	NA	NA	p.Thr78Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.608	-3.765	1.157	19.548	19.548	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T78D	78	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.608	-2.933	0.325	13.979	13.979	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.375	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T78E	78	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.608	-2.909	0.301	13.416	13.416	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.27	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T78F	78	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.608	-3.519	0.911	15.59	15.59	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T78G	78	T	G	missense	possibly_wt-like	0.791182884698042	0.181373029666304	5	0.0811124847237885	0.632205335942861	0.950160433453223	0.502502330215788	0.887907863151667	0.896794009957836	0.724785206138962	NA	NA	NA	0.943925014025958	0.717534105232195	0.546191524563235	0.717534105232195	0.733886609919506	0.613552949945935	NA	NA	NA	0.768254047072417	p.Thr78Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.608	-2.966	0.358	15.814	15.814	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.415	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
T78H	78	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.608	-2.808	0.2	13.88	13.88	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.865	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T78I	78	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.608	-2.999	0.391	14.823	14.823	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.265	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
T78K	78	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.608	-2.742	0.134	11.757	11.757	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T78L	78	T	L	missense	wt-like	1.03379429961817	0.239378848654533	6	0.097726005736421	0.842254848021828	1.22533375121451	0.564948459178541	1.06599419877107	NA	NA	1.23619268649066	1.07109620128168	1.17646880225047	1.08806544973659	0.829952052498689	0.57590192641739	0.799628908838253	NA	NA	0.841893935800548	0.81925580415912	0.921225596100546	0.840648300838258	p.Thr78Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.608	-3.081	0.473	9.149	9.132	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.03	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T78M	78	T	M	missense	wt-like	1.21693770261934	0.114029228477264	5	0.0509954212594035	1.11698851357446	1.31688689166421	NA	1.19078457660752	1.31468042315642	1.34801854003734	1.16062024114557	NA	NA	1.07058473214984	0.85715517285383	NA	0.85715517285383	0.938840030249002	0.88687288905837	0.813664768738372	NA	NA	0.831868644395949	p.Thr78Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.608	-4.177	1.569	4.381	4.381	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.965	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T78N	78	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.608	-3.391	0.783	12.889	12.889	90.32	0.003266442	0	0.093360365	4.08e-06	1	245110	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.76	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
T78P	78	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.608	-2.189	-0.419	27.131	27.131	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
T78Q	78	T	Q	missense	wt-like	0.976579828954294	0.0880309883849871	7	0.033272586133413	0.911366758460298	1.04179289944829	NA	1.03470225328726	0.961233574815821	1.06188249236949	0.818346539054192	0.938686036105869	0.952219598985891	1.06898830806154	0.765491153175887	NA	0.785203848599859	0.765491153175887	0.76138748435888	0.685812593607523	0.753994449867756	0.800446456861802	0.831066843499507	p.Thr78Gln	0	0	NA	NA	NA	NA	NA	NA	NA	0.397	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.608	-4.397	1.789	2.942	NA	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.76	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T78R	78	T	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.608	-3.788	1.18	8.878	8.878	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.31	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T78S	78	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.608	-2.812	0.204	18.391	18.391	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	neutral	0.52	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
T78V	78	T	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.608	-2.818	0.21	13.762	13.762	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.505	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T78W	78	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.608	-5.711	3.103	1.119	NA	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T78X	78	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T78Y	78	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr78Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51	100.9	21.8	0.074	73.6	111.5	-58.5	30.4	35.5828220858896	-1.6	0	0	71.59	0	0	0	0	6	20.8938890075543	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.608	-2.851	0.243	12.916	12.916	90.32	0.003266442	0	0.093360365	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.195	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A79A	79	A	A	synonymous	wt-like	0.925214367114349	0.224466242167432	7	0.0848402649291751	0.758930503414329	1.09149823081437	0.8860939185146	1.16404990409861	1.06366796279678	0.854534603533219	1.05940331158042	0.478516240727484	NA	0.970234628549333	0.775856416750187	0.728695395107863	0.84483093875997	0.815730350988903	0.670454748143808	0.775856416750187	0.527189324970447	NA	0.781467999846297	p.Ala79=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A79C	79	A	C	missense	possibly_wt-like	0.784347318428524	0.181650658332977	4	0.0908253291664885	0.606332944378211	0.962361692478837	NA	NA	NA	NA	0.779726371755005	0.530253289186876	0.892036433205316	0.935373179566898	0.717672702522053	NA	NA	NA	NA	0.671386500212243	0.552689103216435	0.76803220140929	0.763958904831863	p.Ala79Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.334	-3.964	1.63	16.909	16.909	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.085	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A79D	79	A	D	missense	wt-like	1.00498969523696	0.163808940518723	5	0.0732575852644171	0.861407466524334	1.14857192394959	NA	1.19560562495915	0.751453351006604	0.979132503553175	1.08185186760345	NA	NA	1.01690512906244	0.784241801600246	NA	0.859377595007817	0.662603925859514	0.725097349228661	0.784241801600246	NA	NA	0.804908168046616	p.Ala79Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.334	-2.792	0.458	17.424	17.424	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
A79E	79	A	E	missense	wt-like	0.951333113746269	0.119237230216445	8	0.0421567270279748	0.868707447065352	1.03395878042719	1.00639023383486	0.962454832595458	0.687341375622402	0.927468259473577	0.965370016881772	0.979329915573524	1.10819849589008	0.974111780098478	0.762962855812755	0.78592955724257	0.751899003553164	0.631160049667185	0.702439915362281	0.740731424124452	0.774026708072345	0.884455660164385	0.783415291678416	p.Ala79Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.334	-2.407	0.073	11.057	11.057	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.19	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79F	79	A	F	missense	possibly_wt-like	0.715810939616747	0.213777570629358	6	0.0872743277489531	0.544756400453854	0.88686547877964	0.986160860224333	0.566642583876169	0.433833175247499	0.596739317550069	NA	NA	0.868224053880208	0.843265646922203	0.643567146884161	0.776304896287444	0.569436218239156	0.506826328571254	0.557398228160112	NA	NA	0.75520701123584	0.717698075529167	p.Ala79Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.334	-4.658	2.324	3.519	NA	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.545	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A79G	79	A	G	missense	wt-like	1.03587890206517	0.0977071767319182	8	0.0345447036188659	0.968172527115585	1.10358527701476	1.10161804662805	1.0873605135919	1.12516069277221	1.08120136542718	0.942852907374812	1.02102899835565	0.840222369552631	1.08758632281895	0.802028733779009	0.831236714511929	0.809478420385001	0.845889611821042	0.769859805912704	0.732320431954929	0.794579047173017	0.740125489067266	0.840407660274834	p.Ala79Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.334	-3.02	0.686	13.537	13.537	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.85	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
A79H	79	A	H	missense	wt-like	1.15336838151358	0.111493712748603	4	0.0557468563743014	1.04410655076863	1.26263021225854	NA	1.06829018868017	1.0671796153049	1.30208734272918	NA	NA	NA	1.17591637934007	0.842091170648896	NA	0.800687321545852	0.817452649608377	0.866729691689416	NA	NA	NA	0.884771259534234	p.Ala79His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.334	-3.311	0.977	12.475	12.475	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	deleterious	neutral	0.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A79I	79	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala79Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.334	-3.771	1.437	6.064	6.064	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.195	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79K	79	A	K	missense	possibly_low	0.696774456841842	0.262464044486135	2	0.185590105673794	0.333024533834224	1.06052437984946	NA	NA	NA	NA	0.511184351168049	NA	0.882364562515636	NA	0.666949446488162	NA	NA	NA	NA	0.571075897217364	NA	0.76282299575896	NA	p.Ala79Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.334	-2.339	0.005	13.819	13.819	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.575	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79L	79	A	L	missense	wt-like	0.892100913155603	0.0433942232218276	8	0.0153421747522385	0.862030803196695	0.92217102311451	0.926367185464979	0.891821834690533	0.829417837298956	0.915403259700179	0.83255165667719	0.937603409914597	0.872414990711186	0.931227130787202	0.733597425050907	0.747856469860617	0.719338380241198	0.700841800136265	0.697148791117001	0.691118742385511	0.753460852984617	0.757464222123016	0.761876559888175	p.Ala79Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.334	-3.212	0.878	8.223	8.2	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.995	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79M	79	A	M	missense	possibly_wt-like	0.866125582457285	0.244778874490917	8	0.0865424010218692	0.696505593318799	1.03574557159577	0.859718433233006	1.0071695797104	1.02318747635617	0.868989797709151	0.32739568509595	1.02749786699516	0.741529861052263	1.07351595950618	0.744329153990515	0.716146558537354	0.772511749443677	0.795876596737599	0.676794095828103	0.502423878151516	0.797767375860521	0.686970356061407	0.833340847640199	p.Ala79Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.334	-3.903	1.569	6.752	6.752	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A79N	79	A	N	missense	wt-like	1.10721915342784	0.0393802858386446	4	0.0196901429193223	1.06862718245552	1.14581112440016	NA	NA	NA	NA	1.05354365376997	1.14778821102636	1.11822342088049	1.10932132803454	0.854189612857363	NA	NA	NA	NA	0.773667612901072	0.85705520130222	0.88985501852842	0.851324024412505	p.Ala79Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.334	-2.912	0.578	28.293	28.293	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.06	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79P	79	A	P	missense	wt-like	0.826713265124634	0.111770207166536	8	0.0395167357110416	0.749261886344405	0.904164643904864	0.770015557625489	0.856638557760488	0.823558015354463	0.993420165560613	0.962788140204684	0.718051810918506	0.668022362795189	0.821211510777646	0.700543658865113	0.673468036649115	0.703119481695481	0.697967836034744	0.731363225422261	0.739766995519308	0.645249865797232	0.647379703172407	0.706621428502507	p.Ala79Pro	1	0	NA	NA	NA	NA	NA	NA	NA	7.857	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.334	-3.553	1.219	15.591	15.591	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.89	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
A79Q	79	A	Q	missense	wt-like	0.936357019946737	0.19452980700461	8	0.068776672837935	0.80155721820789	1.07115682168558	0.772521384942672	0.73603776442537	1.12761136497858	1.25286909592726	1.01803735990244	0.833288110451048	1.01015435756283	0.740336721383699	0.731225679877259	0.674660250446948	0.647524545626156	0.847091550039034	0.845144953698947	0.760404669022937	0.702046690731582	0.831649735049913	0.666002222671894	p.Ala79Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.334	-2.992	0.658	7.91	7.91	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79R	79	A	R	missense	possibly_wt-like	0.836837996886219	0.27125411342112	8	0.0959028115124093	0.648871940305764	1.02480405346667	0.985808482165694	0.852530103970014	0.745157950557072	0.767388267122107	1.18691779102704	0.263140914139959	0.988604460236474	0.9051560058714	0.725003970848922	0.776137243081383	0.701225553641538	0.659516331207658	0.63223658800021	0.823487898392838	0.421036708399175	0.820043102732519	0.748782388056306	p.Ala79Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.334	-3.091	0.757	14.342	14.342	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A79S	79	A	S	missense	wt-like	1.00043831517752	0.204267949132394	8	0.0722196260052922	0.858890449230199	1.14198618112485	0.533852297623828	1.13126828467808	1.07639695012975	1.12351208864962	0.935169170114644	1.17504981432149	1.03880486049835	0.989453055404433	0.806546865780798	0.561107102922994	0.829719163907304	0.82197331416939	0.788415238791471	0.729450265430759	0.870491701051554	0.847080706633908	0.791120417392206	p.Ala79Ser	1	0	NA	NA	NA	NA	NA	NA	NA	0.092	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.334	-2.112	-0.222	19.427	19.427	86.1	0.003804631	0	0.108742684	3.246e-05	1	30808	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Nov 22, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-1.17	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
A79T	79	A	T	missense	wt-like	0.998153851339622	0.234499932070138	8	0.0829082460772897	0.83565667500675	1.16065102767249	1.25477067469121	0.494471943590717	1.08491040231082	1.23207061105543	0.959470230789749	1.00862151402615	0.959584852295498	0.991330581957396	0.798238367543319	0.904103138746016	0.536166767667609	0.826148757754564	0.836023746103647	0.738527630844212	0.788463736995605	0.804413333631304	0.792063401455334	p.Ala79Thr	1	0	NA	NA	NA	NA	NA	NA	NA	3.695	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.334	-2.489	0.155	22.272	22.272	86.1	0.003804631	0	0.108742684	0.0001015	28	275782	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not specified|not provided|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 12, 2017)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	4	1	0	2	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
A79V	79	A	V	missense	possibly_wt-like	0.74625924654711	0.260517181559607	8	0.0921067328482025	0.565733367430981	0.926785125663239	0.417662599319923	0.484227319744004	0.734483002757299	0.532248449888202	0.700792392701955	1.07599414640491	1.02026299552519	1.0044030660354	0.648091224962643	0.505826772736616	0.531444168486776	0.654280776773964	0.529115658753252	0.641901673151322	0.821669867547397	0.837094180667537	0.798629031183226	p.Ala79Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.334	-3.394	1.06	7.816	7.816	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.34	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
A79W	79	A	W	missense	wt-like	0.923480554314771	0.0994233685801725	6	0.040589420255014	0.843926752461583	1.00303435616796	1.04174426884403	0.810121567026893	0.862016011013484	1.04289523118554	NA	0.927937264046672	NA	0.856168983772009	0.736437712529637	0.802750176946874	0.681675931827733	0.716829654702172	0.753060591703367	NA	0.74869667366892	NA	0.724178751390355	p.Ala79Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.334	-5.813	3.479	0.737	NA	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A79X	79	A	X	nonsense	low	0.0766695579459734	0.161240151040595	6	0.0658260160164581	-0.0523470626920412	0.205686178583988	NA	0.0197801771124756	-0.0106124219590269	-0.0686413851877257	0.155723406415016	-0.00470739487334622	NA	0.368474966168448	0.303181722001236	NA	0.31734185217422	0.288846891047458	0.265594495485349	0.438297788110374	0.289021591828252	NA	0.479235378655208	p.Ala79Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A79Y	79	A	Y	missense	possibly_wt-like	0.800211663919431	0.156336022298248	6	0.0638239138411801	0.675119091438331	0.925304236400532	NA	0.638513722068054	0.59779636154893	0.798193562423274	NA	0.899895934999064	0.863978265366576	1.00289213711069	0.690311083061186	NA	0.602567603386056	0.587242477025047	0.64574629773186	NA	0.734875868390512	0.752920257594797	0.797870170066577	p.Ala79Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	52.5	103.9	20.2	0.974	70.2	55.3	-68.9	-56	66.1157024793389	-3.3	0	0	69.45	0	0	0	0	5	24.2347968396684	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.334	-3.947	1.613	8.506	8.506	86.1	0.003804631	0	0.108742684	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.545	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K80A	80	K	A	missense	wt-like	0.88980237941051	0.226968059684717	8	0.0802453270579081	0.732524428449373	1.04708033037165	0.995996262216212	0.91071766766674	0.999639110634439	1.07246941818863	0.370248609240849	0.983633976603549	0.781734526615879	1.00397946411779	0.771089229601785	0.780984349608726	0.728049041234693	0.784327242785415	0.766030396993503	0.51843106634379	0.776148062210066	0.70862432329725	0.798416277943177	p.Lys80Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.868	-2.968	1.1	10.35	10.35	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K80C	80	K	C	missense	possibly_wt-like	0.78503593819179	0.207866707392148	8	0.0734919791899538	0.640994305826913	0.929077570556666	1.05513294171624	0.852585857293401	0.78920172734356	0.908016062754026	0.362418527507637	0.861492080318755	0.821415991865581	0.63002431673512	0.697580189748192	0.809120193118162	0.701251254985315	0.681117709983114	0.693909124511069	0.515506234623074	0.715947657228493	0.729996498300861	0.610598031777939	p.Lys80Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.868	-3.7	1.832	17.029	17.029	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80D	80	K	D	missense	possibly_wt-like	0.790032998090474	0.242594457120431	8	0.085770092854063	0.621926705145855	0.958139291035094	0.565338609742969	0.822200149642499	0.969869987829137	1.0073576348485	1.1082914740898	0.48397662731358	0.858254026500239	0.504975474757071	0.712359739597646	0.576087550894765	0.687243955136309	0.769726903204008	0.737475524058984	0.794117994770298	0.529880600395486	0.749837220362074	0.547792493868663	p.Lys80Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.868	-3.625	1.757	8.663	8.663	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K80E	80	K	E	missense	possibly_wt-like	0.909578979342659	0.330352552210339	3	0.190729134946119	0.535756744045785	1.28340121463953	1.23787743155931	0.577209946267381	NA	NA	NA	NA	NA	0.913649560201286	0.753048259215223	0.89606573033647	0.574307594457456	NA	NA	NA	NA	NA	0.753048259215223	p.Lys80Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.868	-3.329	1.461	9.804	9.804	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.795	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K80F	80	K	F	missense	wt-like	0.867072013374971	0.0798819059057007	8	0.0282425186800133	0.811717693929445	0.922426332820497	1.03747964128772	0.81338745154446	0.800636963618312	0.909038052111949	0.883060417034216	0.791868127175474	0.842961647598068	0.858143806629567	0.702171497262082	0.800721167293901	0.683181449626935	0.686726149771446	0.694357319519083	0.709985675005081	0.681631912155477	0.741600846123822	0.725170602333414	p.Lys80Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-0.298	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.868	-3.124	1.256	11.765	11.765	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80G	80	K	G	missense	possibly_wt-like	0.718178918300193	0.145733117167872	8	0.0515244376964279	0.617192876091517	0.81916496050887	0.472595954630114	0.945715574565355	0.771736923668181	0.814624834374158	0.755147382254925	0.57711350076366	0.66710988946742	0.741387286677732	0.65757878761959	0.531962773295376	0.744182487315617	0.672552054016331	0.652952257369904	0.662205317869275	0.575785221749482	0.646888251066885	0.666529867049537	p.Lys80Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.868	-3.924	2.056	2.8	NA	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.02	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K80H	80	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys80His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.868	-2.717	0.849	10.718	10.718	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80I	80	K	I	missense	possibly_low	0.530732548304087	0.565066705759672	7	0.213575139657514	0.112132966582247	0.949332130025928	NA	0.927949740253796	0.939967859454984	1.09886072202958	-0.152628920362674	-0.0838791416981843	0.0341096590172788	0.950747919433827	0.735992736689145	NA	0.735992736689145	0.755061330713854	0.777604343967406	0.3231165298241	0.25	0.305958509249741	0.771680838056379	p.Lys80Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.868	-2.934	1.066	9.096	9.096	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K80K	80	K	K	synonymous	wt-like	1.1804314885549	0.158600054228719	5	0.0709281004981138	1.04141496608676	1.31944801102305	NA	1.24588467826578	0.999381636686067	1.35398845347148	NA	1.27744939565542	NA	1.02545327869578	0.88255539240788	NA	0.88255539240788	0.784200964053449	0.889491003795781	NA	0.920961658156794	NA	0.809201459590615	p.Lys80=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K80L	80	K	L	missense	wt-like	0.951518674878111	0.0983986529055035	8	0.0347891773645514	0.883333140191814	1.01970420956441	0.815140294835902	0.908747273624637	0.934649716418497	1.09634236470935	0.981222479272659	1.04390874863528	0.831933708216733	1.00020481331184	0.74955297642747	0.694937327033539	0.727140722742147	0.75245303436656	0.776499914483306	0.74665291848838	0.805855851239488	0.735661270835864	0.796520466910166	p.Lys80Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.868	-2.42	0.552	13.604	13.604	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.645	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K80M	80	K	M	missense	possibly_low	0.687158514927073	0.663161892019008	5	0.296575014128375	0.105882168521	1.26843486133315	1.05640082398783	NA	NA	-0.0378130798999614	0.0123349799626406	1.4378119871511	NA	0.967057863433757	0.779872475739562	0.809723421731664	NA	NA	0.279114296282084	0.384736786787428	1	NA	0.779872475739562	p.Lys80Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.868	-4.927	3.059	1.806	NA	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80N	80	K	N	missense	wt-like	0.962781312657446	0.128128513938564	8	0.0453002705346569	0.873994413919597	1.05156821139529	1.07384686032592	0.910280565803077	1.05020927629754	1.18356507152251	0.788620312026339	0.907919156499424	0.876476118692891	0.911333140091875	0.755768180268896	0.818023836168497	0.727847544631777	0.809129505055559	0.814751566984426	0.674708723340184	0.738830295153728	0.759651518821636	0.751884841716155	p.Lys80Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.868	-2.839	0.971	11.003	11.003	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.92	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K80P	80	K	P	missense	possibly_wt-like	0.738863342308758	0.203880134421743	8	0.0720825127994197	0.597584213306748	0.880142471310768	1.02545887484247	0.905509987599264	0.79766455208708	0.738981982068111	0.526365674961542	0.417868583541772	0.628731857662133	0.870325225707697	0.655743209960693	0.795001968880553	0.725648388366546	0.685268323216881	0.619778967909827	0.576746695927589	0.497297751032127	0.626218096704504	0.731288696396489	p.Lys80Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.868	-3.253	1.385	15.223	15.223	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80Q	80	K	Q	missense	possibly_wt-like	0.83218166836289	0.266954943672982	6	0.108983899385372	0.618577150672825	1.04578618605296	1.02694181010906	1.08202170069064	0.881783626951993	0.602993584017305	0.411690790502239	NA	NA	0.987658497906103	0.75837191749463	0.795707514659385	0.807017317487387	0.726524730613702	0.560141046358435	0.533911288704025	NA	NA	0.790219104375557	p.Lys80Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.868	-3.556	1.688	4.884	4.884	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K80R	80	K	R	missense	wt-like	0.966141153054572	0.127760184555493	8	0.0451700464324168	0.877609488867033	1.05467281724211	0.958158846712265	0.889947499089197	0.765405201196128	0.87953445753559	1.10901980657952	1.12305100106507	1.08258600200686	0.921426410251953	0.759968181410049	0.762982195777614	0.718474343073223	0.669446645139092	0.681418472646487	0.794390054506295	0.844862906085912	0.870660940183493	0.756954167042484	p.Lys80Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.868	-2.595	0.727	16.562	16.562	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.17	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K80S	80	K	S	missense	wt-like	0.895830439735087	0.13263199079408	8	0.0468924900463829	0.803922848098774	0.987738031371401	1.0307536048488	0.872673266288061	0.916921754322131	1.01895952409055	0.66638162062448	0.98472272924684	0.734235870681024	0.941995147778813	0.743160931085606	0.797521077091267	0.710511212469619	0.743758311704219	0.742563550466994	0.629047948102757	0.776684678654092	0.683041861039668	0.767284775499585	p.Lys80Ser	0	0	NA	NA	NA	NA	NA	NA	NA	2.534	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.868	-3.084	1.216	7.203	7.203	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K80T	80	K	T	missense	possibly_wt-like	0.791106853623533	0.140689281073893	7	0.0531755499791411	0.686884690806306	0.895329016440759	1.06589446323118	0.830529114584507	NA	0.681269567727562	0.621464663348383	0.776419868373073	0.79590437720412	0.766265920895905	0.679025112745573	0.814240272362173	0.691083467801768	NA	0.594469099654027	0.612269765458519	0.674017887283976	0.716256111202289	0.679025112745573	p.Lys80Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.868	-3.971	2.103	2.69	NA	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K80V	80	K	V	missense	wt-like	1.0077226732173	0.125235873455363	8	0.0442775676840536	0.920940235233518	1.09450511120108	0.846231231821168	0.97382160292955	1.04704672944278	1.21242968720814	0.883900033666325	1.10211946640068	1.08379213645376	0.912440497815979	0.782358659771422	0.709729664800471	0.757138893379449	0.807578426163396	0.827410188679696	0.710299303577873	0.834546324290393	0.871310556227527	0.752441009981452	p.Lys80Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.868	-3.322	1.454	8.551	8.551	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K80W	80	K	W	missense	possibly_wt-like	0.77572386482086	0.160371322445618	7	0.060614662373951	0.656921309632861	0.894526420008859	0.888785304991785	0.648895658552288	0.691203437767763	0.821541977140895	0.517282896847636	0.954397610791142	NA	0.907960167654511	0.655985780991002	0.729975893596884	0.607353501381875	0.633054207556067	0.655985780991002	0.573353934722161	0.761738255946763	NA	0.750190772863291	p.Lys80Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.868	-4.259	2.391	12.691	12.691	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.02	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K80X	80	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys80Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K80Y	80	K	Y	missense	possibly_wt-like	0.93959377558602	0.328267446216979	7	0.124073432315485	0.6964143168094	1.18277323436264	0.340197744051781	0.908586189027503	1.00064735531272	1.0462513972963	1.33273375307601	0.735373317610834	NA	1.213366672727	0.754532443523786	0.468970813563179	0.727066465453851	0.784821738870512	0.754532443523786	0.877955676089009	0.653787163395247	NA	0.903580596620609	p.Lys80Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.1	105.8	19.9	0.71	94.1	81.2	-49.8	-27.1	42.1739130434783	-2	0	0	68.58	0	0	1	29	4	23.4238288471377	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.868	-2.55	0.682	10.632	10.632	42.43	0.003148132	0	0.089978858	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F81A	81	F	A	missense	possibly_wt-like	0.725393649167545	0.138326460702804	2	0.0978115783804875	0.533686478270773	0.917100820064317	NA	NA	NA	NA	0.823205227548032	NA	NA	0.627582070787058	0.648499458024245	NA	NA	NA	NA	0.687627497552597	NA	NA	0.609371418495893	p.Phe81Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-0.947	-3.486	2.539	1.707	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81C	81	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe81Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-0.947	-5.066	4.119	0.5	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Jan 20, 2016)	criteria provided, single submitter	0	1	0	0	0	4	0	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F81D	81	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe81Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-0.947	-4.158	3.211	1.737	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81E	81	F	E	missense	low	0.412882015352154	0.117968010379815	5	0.0527568980759334	0.309480395187274	0.516283635517034	NA	0.432960625989444	NA	NA	0.454131105128029	0.572098531827821	0.346719956551933	0.258499857263545	0.50781108546177	NA	0.50781108546177	NA	NA	0.549764351632875	0.573313480519891	0.474328350050715	0.424000593893138	p.Phe81Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-0.947	-4.104	3.157	1.032	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81G	81	F	G	missense	possibly_low	0.689136315063387	0.16925457385794	8	0.0598405284608944	0.57185103446419	0.806421595662584	0.768312718919114	0.668260760067068	0.760668717072716	0.913466877997692	0.36432166947336	0.615273386016364	0.826356176361803	0.596430214598977	0.641702056056013	0.672657865977216	0.616280487274071	0.667123624837955	0.696299587937011	0.516217130138604	0.594593187043444	0.732657249030175	0.593725459254557	p.Phe81Gly	0	0	NA	NA	NA	NA	NA	NA	NA	11.7585	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-0.947	-3.855	2.908	1.335	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81H	81	F	H	missense	possibly_wt-like	0.717751975493256	0.169671681571152	8	0.059987998307143	0.600177659306606	0.835326291679906	0.818288762131992	0.836312769456293	0.707636783058229	0.817072549076267	0.750181064105621	0.312602166654252	0.742367479048618	0.757554230414777	0.667499946652526	0.696435293843416	0.6937496353613	0.641113982218174	0.654025706424948	0.660350210176512	0.445414808975849	0.687421491580008	0.674649683128541	p.Phe81His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-0.947	-4.8	3.853	0.668	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81I	81	F	I	missense	possibly_low	0.671659066548208	0.172349430879411	4	0.0861747154397056	0.502759727908397	0.840558405188018	0.774655474633671	0.826272667764111	0.43937001779461	0.646338106000439	NA	NA	NA	NA	0.627412726744032	0.675675600211065	0.689121317451688	0.509541886632044	0.579149853277	NA	NA	NA	NA	p.Phe81Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-0.947	-2.757	1.81	8.422	8.422	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F81K	81	F	K	missense	low	0.435804795852904	0.107435818792911	8	0.0379842980053982	0.361356939784287	0.510252651921521	0.43221862217498	0.438790405314817	0.457701973161267	0.402353202683485	0.263230162491697	0.481983717840469	0.367849911332977	0.642310371823539	0.511625351118594	0.512752186619036	0.510498515618152	0.518532839281032	0.472149897896216	0.478455628229788	0.52889834974258	0.485708804087811	0.61676867907387	p.Phe81Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-0.947	-4.08	3.133	1.139	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81L	81	F	L	missense	wt-like	0.960967093270934	0.169319515558049	8	0.0598634888191589	0.843636811196466	1.0782973753454	1.15272089565988	1.02953343809072	0.899225320262933	1.06046555354409	0.827816558764534	0.626056711953474	1.07003725293889	1.02188101495295	0.77179359771817	0.855550250128097	0.782821111783134	0.735079052045341	0.760766083653207	0.689350004197647	0.599907993905037	0.863902266846476	0.807407297066808	p.Phe81Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-0.947	-1.975	1.028	10.623	10.623	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	low	1.825	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F81M	81	F	M	missense	wt-like	0.97541247826351	0.25373190493226	6	0.103585616424735	0.772388400754649	1.17843655577237	1.27502280765107	0.927814226951434	0.933273524687594	1.13661040383211	NA	0.531748951858363	NA	1.04800495460049	0.772968801422728	0.913738628065137	0.735930267337385	0.751778077743494	0.794159525101962	NA	0.553426274500639	NA	0.820527994995071	p.Phe81Met	0	0	NA	NA	NA	NA	NA	NA	NA	8.748	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-0.947	-4.414	3.467	1.41	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81N	81	F	N	missense	low	0.554352832388078	0.156352378467694	6	0.0638305912193951	0.429247172486165	0.679458492289991	NA	0.725508488078282	0.398028443626569	0.676082063961371	0.480863856474163	NA	0.674953710969244	0.370680431218841	0.57597207868969	NA	0.642670726433226	0.489265809784532	0.59219411188235	0.559750045497029	NA	0.651112881502761	0.480343069191474	p.Phe81Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-0.947	-3.322	2.375	6.602	6.602	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81P	81	F	P	missense	possibly_wt-like	0.751828480998084	0.392043092119931	8	0.138608164477673	0.480161470658641	1.02349549133753	0.721504701441313	0.713436060593634	0.704609679919292	0.297838822208905	1.65945922740996	0.685600548647482	0.60818805682919	0.623990750934896	0.633180532702392	0.65038771036691	0.637105540536433	0.639629332029941	0.426314955260841	1	0.629255524868351	0.61515334131107	0.607567685078203	p.Phe81Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-0.947	-4.492	3.545	0.46	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81Q	81	F	Q	missense	possibly_wt-like	0.96267606945481	0.360510826797065	7	0.136260284664474	0.695610818989266	1.22974131992035	0.830741214838887	0.739328999588941	0.770267672555076	0.77933226474966	1.65945922740996	1.25889682614895	NA	0.700706280892194	0.67183145619012	0.702359878443566	0.649041749646526	0.67183145619012	0.637474646567941	1	0.911817603318037	NA	0.646097910938343	p.Phe81Gln	0	0	NA	NA	NA	NA	NA	NA	NA	10.292	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-0.947	-4.523	3.576	0.715	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81R	81	F	R	missense	low	0.401460917795314	0.155282562971342	5	0.0694444733048623	0.265352251192431	0.537569584398197	NA	0.464086273759626	0.494516745178848	0.534542651706592	0.1464751732197	NA	NA	0.367683745111804	0.522159485252899	NA	0.522159485252899	0.536588734867349	0.530121784496546	0.434843223173268	NA	NA	0.478837989416878	p.Phe81Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-0.947	-4.341	3.394	0.924	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81S	81	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe81Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-0.947	-3.835	2.888	1.469	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F81T	81	F	T	missense	low	0.601443457254177	0.12584971018715	7	0.04756671938925	0.508214400388524	0.69467251411983	0.391291317944867	0.728527855485773	0.548632675867086	0.640382069215956	0.692174480908054	NA	0.709804595172527	0.499291206184974	0.576537824165682	0.493279936286126	0.644062603993457	0.563130026324933	0.576537824165682	0.638682557101203	NA	0.669883337470961	0.544937581023057	p.Phe81Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-0.947	-3.808	2.861	1.231	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F81V	81	F	V	missense	possibly_wt-like	0.808960392222195	0.301769352712166	8	0.106691577828524	0.599848742224537	1.01807204221985	1.13238639688002	0.951702915633395	0.715234357243071	1.00662964756894	0.716018625221096	0.153607208568921	0.970904889221412	0.82519909744071	0.722890225135784	0.845875573085861	0.746942550783674	0.644840231184901	0.737156264115554	0.647589246969367	0.367050536290515	0.810510230726851	0.708624186156014	p.Phe81Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-0.947	-2.884	1.937	6.614	6.614	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.025	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F81W	81	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe81Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-0.947	-4.881	3.934	0.209	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F81X	81	F	X	nonsense	low	0.0523915001633045	0.125968112552125	7	0.0476114712767308	-0.0409252687900511	0.14570826911666	-0.0415173279307229	0.109526507698983	0.0107951833710632	-0.0410180445912287	0.310027925727875	NA	0.0455650716030557	-0.0266388147358938	0.299346303794292	0.287359745419107	0.358713400183436	0.299346303794292	0.277708754077216	0.49593636304653	NA	0.312128318781249	0.280790249915661	p.Phe81Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F81Y	81	F	Y	missense	possibly_low	0.705558745341364	0.383982367010897	3	0.221692322957811	0.271049776695032	1.1400677139877	NA	NA	0.262188423835314	NA	NA	0.924157373896634	NA	0.930330438292143	0.746833669042828	NA	NA	0.422642737594305	NA	NA	0.746833669042828	NA	0.761426197824836	p.Phe81Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.6	105.4	23.7	0.767	68.7	-154.9	-91.6	114.1	2.19298245614035	-2.7	0	0	70.88	0	0	0	0	6	22.2815676706106	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-0.947	-3.518	2.571	0.632	NA	24.32	0.001399215	0	0.039991895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N82A	82	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.197	-3.203	1.006	9.76	9.272	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.25	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N82C	82	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.197	-5.562	3.365	1.628	NA	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.8	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N82D	82	N	D	missense	wt-like	1.23272525414893	0.369647227693618	3	0.213415926414109	0.814437724650029	1.65101278364784	NA	NA	NA	NA	1.65945922740996	1.0114424611652	1.02727407387164	NA	0.840870301141959	NA	NA	NA	NA	1	0.789854104800333	0.840870301141959	NA	p.Asn82Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.197	-2.354	0.157	19.098	19.098	89.33	0.003520021	0	0.100608066	0	NA	NA	not specified	Uncertain significance(Last reviewed: Feb 16, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.115	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
N82E	82	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.197	-2.481	0.284	13.563	13.563	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.325	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N82F	82	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.197	-3.653	1.456	16.929	16.929	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.9	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N82G	82	N	G	missense	wt-like	1.21823231797355	0.0499268749173563	7	0.0188705849671362	1.18124665107076	1.25521798487633	1.14974174343839	1.19867383299009	1.199508454267	1.24010106467921	1.29570388102016	1.26083547205002	1.18306177736995	NA	0.864123618124201	0.854132839455005	0.860791987273491	0.882353654515242	0.839545513916943	0.864123618124201	0.91277310893822	0.924776528939371	NA	p.Asn82Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.197	-2.547	0.35	18.218	18.218	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N82H	82	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.197	-2.098	-0.099	18.097	18.097	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.03	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N82I	82	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.197	-4.441	2.244	4.141	NA	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.45	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N82K	82	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.197	-2.625	0.428	11.207	11.207	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	0.965	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N82L	82	N	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.197	-3.552	1.355	13.511	13.511	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.9	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N82M	82	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.197	-4.158	1.961	4.26	4.26	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N82P	82	N	P	missense	wt-like	0.98384380780963	0.0889772858989809	4	0.0444886429494905	0.896647669907567	1.07103994571169	NA	0.884576381590623	NA	NA	1.10093784859262	NA	0.971260226055257	0.978600775000018	0.788520509061196	NA	0.715998348299919	NA	NA	0.791371137476949	NA	0.810701612797811	0.785669880645443	p.Asn82Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.197	-3.367	1.17	17.923	17.923	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N82Q	82	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.197	-2.938	0.741	9.661	9.661	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.15	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N82R	82	N	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.197	-3.177	0.98	18.781	18.781	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.48	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N82S	82	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.197	-3.131	0.934	19.646	19.646	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.355	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N82T	82	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Thr	1	0	NA	NA	NA	NA	NA	NA	39.2	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.197	-3.372	1.175	9.031	9.031	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.45	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
N82V	82	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.197	-4.115	1.918	3.682	NA	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.25	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N82W	82	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.197	-4.277	2.08	25.505	25.505	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.8	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N82X	82	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N82Y	82	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn82Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	108	25.7	0.316	73	58.9	-79.9	56.5	51.3368983957219	-1.4	0	0	78.28	1	19	0	0	3	25.4747309673724	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.197	-3.116	0.919	15.831	15.831	89.33	0.003520021	0	0.100608066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
C83A	83	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-3.103	-3.02	-0.083	8.194	8.194	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C83D	83	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-3.103	-2.603	-0.5	12.01	12.01	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83E	83	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-3.103	-3.451	0.348	6.192	6.192	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C83F	83	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-3.103	-3.59	0.487	12.147	12.147	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.14	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
C83G	83	C	G	missense	possibly_low	0.580416039983632	0.297372506614815	3	0.171688096743657	0.243913553791835	0.916918526175428	0.407334599982949	NA	NA	NA	0.410125065997725	0.923788453970221	NA	NA	0.533326431373957	0.500912953165287	NA	NA	NA	0.533326431373957	0.746651838486309	NA	NA	p.Cys83Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-3.103	-1.881	-1.222	32.767	32.767	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-2.215	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
C83H	83	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-3.103	-2.798	-0.305	17.043	17.043	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.725	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83I	83	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-3.103	-4.311	1.208	5.052	NA	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.205	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
C83K	83	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-3.103	-3.089	-0.014	13.132	13.132	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.625	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83L	83	C	L	missense	possibly_low	0.664582288605594	0.438171626540762	8	0.154917064225256	0.360950422133413	0.968214155077774	0.730192832645052	0.982206502117889	1.00091699332514	1.01751625984022	-0.211640524685952	0.812995519937028	0.216656442579866	0.767814283085505	0.685923900852491	0.65452131918642	0.761004190791118	0.784953983497646	0.741930604705641	0.30107346334078	0.692045027058203	0.40427700076954	0.679802774646779	p.Cys83Leu	0	0	NA	NA	NA	NA	NA	NA	NA	11.621	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-3.103	-3.488	0.385	8.759	8.759	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.69	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
C83M	83	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-3.103	-4.122	1.019	4.944	4.944	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83N	83	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-3.103	-2.123	-0.98	17.29	17.29	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-2.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C83P	83	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-3.103	-3.208	0.105	16.696	16.696	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.63	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
C83Q	83	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-3.103	-3.098	-0.005	11.732	11.732	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.21	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C83R	83	C	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-3.103	-3.688	0.585	13.488	13.488	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
C83S	83	C	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-3.103	-3.003	-0.1	15.88	15.88	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	neutral	neutral	-0.955	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
C83T	83	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-3.103	-3.956	0.853	5.931	NA	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83V	83	C	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-3.103	-3.255	0.152	8.284	8.284	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C83W	83	C	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-3.103	-5.589	2.486	0.996	NA	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.69	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
C83X	83	C	X	nonsense	low	-0.0976450390128623	0.0936596138481313	5	0.0418858526621604	-0.179739801692448	-0.0155502763332768	NA	-0.0597820316205463	-0.0705420065832554	-0.0355764550469527	-0.263629185621876	NA	-0.0586955161916814	NA	0.280095171558472	NA	0.280665012945181	0.259454278701804	0.280095171558472	0.281653731873875	NA	0.255974255056365	NA	p.Cys83Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C83Y	83	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys83Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.5	105.7	28.7	0.865	98.2	-65.3	-159.3	-168.6	25	-3.2	0	0	72.71	0	0	0	0	5	23.9639708283081	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-3.103	-2.523	-0.58	11.499	11.499	43.18	0.003962831	0	0.113264301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	-0.725	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	B	0.571428571428571
R84A	84	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.697	-3.08	1.383	6.541	6.541	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84C	84	R	C	missense	possibly_wt-like	1.19071518078213	0.543039060349649	3	0.313523747673351	0.576219927044342	1.80521043451993	1.31703788314169	NA	NA	NA	1.65945922740996	NA	NA	0.595648431794753	0.933728414421687	0.933728414421687	NA	NA	NA	1	NA	NA	0.593332810360166	p.Arg84Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.697	-3.815	2.118	13.671	13.671	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84D	84	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.697	-3.467	1.77	13.388	13.388	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84E	84	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.697	-3.164	1.467	9.214	9.214	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84F	84	R	F	missense	possibly_wt-like	0.844060185974911	0.149870187346941	4	0.0749350936734703	0.697190101196774	0.990930270753048	NA	0.817311836800399	0.88723310722935	1.01566580862178	NA	NA	NA	0.656029991248114	0.707093983409213	NA	0.68499052518425	0.729197441634176	0.741119086471868	NA	NA	NA	0.623659331272171	p.Arg84Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.697	-4.567	2.87	4.399	NA	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84G	84	R	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.697	-3.785	2.088	3.34	NA	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R84H	84	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.697	-3.459	1.762	12.826	12.826	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84I	84	R	I	missense	wt-like	1.12483177362771	0.0909838483123258	5	0.040689213936178	1.04508237975356	1.20458116750187	NA	1.07271273772389	1.22859453042901	1.10777703605173	1.2043362387148	NA	1.01073832521912	NA	0.829994347502648	NA	0.802726042225455	0.896618992188555	0.781514607223701	0.829994347502648	NA	0.831964256171254	NA	p.Arg84Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.697	-3.668	1.971	7.411	7.411	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R84K	84	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Lys	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.697	-2.286	0.589	11.963	11.963	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.325	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
R84L	84	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.697	-3.345	1.648	9.225	9.225	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84M	84	R	M	missense	low	0.0337643026097392	0.0504151328179786	2	0.0356488822900132	-0.0361062227677943	0.103634827987273	NA	NA	-0.0018845796802739	0.0694131848997524	NA	NA	NA	NA	0.309633011375882	NA	NA	0.293127482783942	0.326138539967821	NA	NA	NA	NA	p.Arg84Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.697	-3.348	1.651	5.788	5.788	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84N	84	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.697	-2.364	0.667	11.631	11.631	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R84P	84	R	P	missense	wt-like	1.21375648148957	0.0670083819618126	5	0.0299670594257768	1.15502212429248	1.27249083868666	1.2964866927686	1.16661944653118	1.19380073566794	1.2706440591412	NA	NA	NA	1.14123147333893	0.867350832889122	0.92395064060756	0.846015454577122	0.879554289874018	0.852940191211312	NA	NA	NA	0.867350832889122	p.Arg84Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.697	-3.441	1.744	17.31	17.31	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84Q	84	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.697	-2.493	0.796	17.89	17.89	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
R84S	84	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.697	-2.943	1.246	6.767	6.767	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R84T	84	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.697	-3.249	1.552	8.665	8.665	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.05	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R84V	84	R	V	missense	possibly_wt-like	0.82909812872959	0.250186263880992	2	0.176908403749977	0.482364028817165	1.17583222864201	1.00600653247957	NA	NA	NA	0.652189724979613	NA	NA	NA	0.704746869690612	0.785747001147468	NA	NA	NA	0.623746738233756	NA	NA	NA	p.Arg84Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.697	-3.309	1.612	8.818	8.818	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84W	84	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.697	-4.174	2.477	10.227	10.227	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R84X	84	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R84Y	84	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg84Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	51.6	102.3	29.9	0.75	38.7	-156.3	-93.1	141.1	58.4905660377358	-3.3	0	0	64.42	1	1	0	0	4	22.5606816798607	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.697	-3.551	1.854	10.632	10.632	43.18	0.003327318	0	0.09510028	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85A	85	V	A	missense	possibly_low	0.548038334353039	0.244643144319977	8	0.0864944131597276	0.378512399696046	0.717564269010033	0.554737579299255	0.757913912569272	0.601645676919961	0.970292146537774	0.276321575372819	0.301100990015917	0.313196239514218	0.609098554595099	0.580087106380502	0.57104382953393	0.657609081754569	0.589130383227073	0.721220397034741	0.483345766157885	0.439746193108137	0.456272697549148	0.600088108402589	p.Val85Ala	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.218	-2.563	1.345	8.338	8.338	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V85C	85	V	C	missense	possibly_wt-like	0.927659140217889	0.280903799818731	5	0.125623998306535	0.681440627943159	1.17387765249262	1.29868019929063	0.878942748755558	0.94279302632973	1.00228780629025	NA	NA	NA	0.515591920423284	0.735252142931108	0.924994259504703	0.71340133837451	0.756446940764079	0.735252142931108	NA	NA	NA	0.5531245830764	p.Val85Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.218	-3.779	2.561	17.029	17.029	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85D	85	V	D	missense	low	0.281859090162748	0.171258088894891	5	0.0765889456931354	0.131747514990309	0.431970665335188	0.0509661043153623	0.375811091710729	0.375234109853591	0.152792989604512	NA	NA	NA	0.454491155329547	0.478086272658294	0.331361190865336	0.48146611196074	0.478086272658294	0.362704881826595	NA	NA	NA	0.522436842528957	p.Val85Asp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.218	-4.123	2.905	6.715	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V85E	85	V	E	missense	low	0.452343841671297	0.230757731270265	5	0.103197994690788	0.250079488800595	0.654608194541998	NA	0.223708442980128	0.750311996773515	0.643566414314852	0.2953571605343	NA	0.348775193753686	NA	0.490456277286591	NA	0.41134935071643	0.662044145865499	0.577934323616537	0.490456277286591	NA	0.475435287228397	NA	p.Val85Glu	0	1	NA	NA	NA	NA	NA	NA	NA	8.604	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.218	-3.346	2.128	22.04	22.04	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85F	85	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Phe	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.218	-2.856	1.638	12.721	12.721	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	3	0	0	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
V85G	85	V	G	missense	low	0.374349883170562	0.130806145889017	8	0.0462469563895005	0.283707514252546	0.464992252088577	0.448442939156325	0.417738457277729	0.434780997950384	0.592123003610421	0.185816633636115	0.247167757137295	0.277775705144249	0.390953571451975	0.495659568175106	0.520471335673295	0.500793921868055	0.50729119054974	0.555373736567186	0.449538746832635	0.413163975539743	0.437195431764914	0.490525214482157	p.Val85Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.218	-3.85	2.632	2.648	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Nov 29, 2013)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V85H	85	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.218	-4.977	3.759	1.867	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85I	85	V	I	missense	wt-like	1.10220201883532	0.132352730097152	4	0.0661763650485758	0.97249872671234	1.23190531095831	NA	0.905607499399848	1.14673867237502	1.16485149698233	NA	NA	NA	1.1916104065841	0.831508642538899	NA	0.725693339665535	0.856472585049452	0.806544700028346	NA	NA	NA	0.892653554223512	p.Val85Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.218	-2.302	1.084	7.816	7.816	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.205	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	.	D	0.714285714285714
V85K	85	V	K	missense	low	0.385988153454939	0.218454300526218	4	0.109227150263109	0.1719068728053	0.600069434104577	NA	0.0965319860604492	0.560614864865471	NA	0.337822151449327	NA	NA	0.548983611444507	0.537662639083134	NA	0.35272314440014	0.569006720423352	NA	0.506318557742916	NA	NA	0.569895495010605	p.Val85Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.218	-3.99	2.772	5.645	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85L	85	V	L	missense	possibly_low	0.648471090834537	0.385655082909371	7	0.14576392017517	0.362779057045833	0.934163124623242	0.871132645702522	0.758704655117985	0.844617458719886	1.12862024072232	0.0118852284985525	0.253633181134093	NA	0.670704225946406	0.657973600761677	0.721577172811624	0.657973600761677	0.708296491888716	0.790655426755669	0.384568787602563	0.416350606456929	NA	0.631029437136846	p.Val85Leu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.218	-2.861	1.643	10.529	10.529	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
V85M	85	V	M	missense	possibly_low	0.700349919548492	0.377762284294353	7	0.142780722706077	0.420504845357981	0.980194993739003	0.827439150417388	0.797966330528754	0.409698886143901	-0.0102004708333814	1.11980115248114	NA	0.906311235848357	0.851433152253285	0.700788833728055	0.700788833728055	0.67607257236936	0.494989607053694	0.291223848544967	0.798417295033211	NA	0.775720515797615	0.721800189211959	p.Val85Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.218	-4.547	3.329	1.397	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85N	85	V	N	missense	possibly_low	0.572277520597181	0.172455193219507	6	0.070404537813479	0.434287162134574	0.710267879059788	NA	0.777081619727228	0.605440347843939	0.760344340365529	0.49136536630965	NA	0.353950393058657	0.445483056278083	0.5773321227966	NA	0.666445072170329	0.590991488925488	0.629147463064967	0.563672756667713	NA	0.478222615380934	0.517912542283406	p.Val85Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.218	-3.505	2.287	8.095	8.095	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85P	85	V	P	missense	possibly_low	0.579070468516634	0.605261691705487	5	0.270681257365998	0.0485449527892611	1.10959598424401	NA	0.271317365351091	0.270654170915107	0.363462305715087	1.65945922740996	NA	NA	0.330459273191927	0.45509423509182	NA	0.433296262692277	0.426794784095093	0.45509423509182	1	NA	NA	0.460142070723548	p.Val85Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.218	-4.285	3.067	1.942	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85Q	85	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.218	-3.571	2.353	5.786	5.786	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85R	85	V	R	missense	low	0.236401319782578	0.109162386432673	8	0.0385947318485248	0.160757035366488	0.312045604198667	0.403130179589843	0.149568885323002	0.239231843631123	0.354778126245075	0.102989391983447	0.23915495348756	0.118208970355192	0.284148207645379	0.414991632612135	0.498912588666833	0.377172262372553	0.411383626306373	0.451285774801132	0.418599638917896	0.409214683450589	0.351253842682787	0.436882428036787	p.Val85Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.218	-4.351	3.133	3.679	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85S	85	V	S	missense	possibly_wt-like	0.827288728451959	0.141944092128221	2	0.100369630093233	0.630567868327615	1.0240095885763	NA	0.927658358545192	0.726919098358727	NA	NA	NA	NA	NA	0.693214727931061	NA	0.735858414625304	0.650571041236819	NA	NA	NA	NA	NA	p.Val85Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.218	-3.265	2.047	7.203	7.203	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85T	85	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.218	-2.99	1.772	5.37	5.37	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85V	85	V	V	synonymous	wt-like	1.0405346534637	0.225523667316441	8	0.079734657238757	0.884257596956089	1.19681170997131	0.657799723315341	1.02892731402657	1.14754323293539	1.26862620227592	1.31096245990198	0.785485530174804	1.12071528196468	1.00421748311491	0.825295539747555	0.620078377640109	0.782541698790359	0.856867183757384	0.852055256973108	0.869823274532293	0.678486104402676	0.891197118444358	0.798535822522002	p.Val85=	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V85W	85	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.218	-5.431	4.213	0.921	NA	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V85X	85	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V85Y	85	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val85Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	49.8	99.3	28.3	0.831	10.5	-160.7	-122.3	93.8	4.24242424242424	-1	0	1	51.19	0	0	0	0	5	19.0039205918147	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.218	-2.713	1.495	10.632	10.632	74.19	0.001914751	0	0.054726761	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86C	86	A	C	missense	wt-like	0.938400962788767	0.0353501844135463	2	0.0249963551150136	0.889409007018567	0.987392918558967	NA	NA	NA	0.913404607673753	NA	NA	NA	0.963397317903781	0.737153126525087	NA	NA	NA	0.696272279190476	NA	NA	NA	0.778033973859697	p.Ala86Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.062	-3.363	1.301	17.749	17.749	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86D	86	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.062	-3.609	1.547	10.041	10.041	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86E	86	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.062	-2.358	0.296	12.605	12.605	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A86F	86	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.062	-3.677	1.615	9.469	9.469	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86G	86	A	G	missense	wt-like	0.9498084045028	0.120862948376932	8	0.042731505195764	0.866056193313916	1.03356061569168	0.802588089151095	0.795891348642584	0.866941608921762	0.945959151706631	1.01263306078369	1.0733333310505	0.978097507906594	1.12302313785954	0.738815692597534	0.688965282308812	0.675116040640866	0.719245426324758	0.710549124649371	0.75838595887031	0.82035842432612	0.814384127628255	0.85820573177402	p.Ala86Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.062	-2.939	0.877	15.814	15.814	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A86H	86	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.062	-3.324	1.262	10.454	10.454	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A86I	86	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.062	-2.948	0.886	8.963	7.681	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A86K	86	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.062	-2.811	0.749	20.557	20.557	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A86L	86	A	L	missense	low	0.451090774644765	0.198724747681493	7	0.0751108945313273	0.303876126516777	0.598305422772753	0.765024295713765	0.584910846081883	0.354709500726313	0.284025020893869	NA	0.276105786952177	0.608639074935972	0.284220897209377	0.468019927573361	0.671093311432039	0.577857579669194	0.468019927573361	0.42025689140421	NA	0.427426740137428	0.615396256683456	0.436918936229067	p.Ala86Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.062	-2.517	0.455	10.902	10.902	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.305	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
A86M	86	A	M	missense	possibly_wt-like	0.863931792051681	0.309546098018963	4	0.154773049009482	0.560582190215644	1.16728139388772	NA	0.584969066749681	0.637851939144484	0.991974055823209	1.24093210648935	NA	NA	NA	0.668808432727599	NA	0.57788441841722	0.606887833687029	0.730729031768169	0.84366428845104	NA	NA	NA	p.Ala86Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.062	-3.332	1.27	5.024	5.024	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.155	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A86N	86	A	N	missense	possibly_low	0.627234626805937	0.177857238821886	3	0.10268592471114	0.425973912652911	0.828495340958962	NA	0.498584447489531	NA	NA	NA	NA	0.552923336236083	0.830196096692195	0.585388127939812	NA	0.538062562753336	NA	NA	NA	NA	0.585388127939812	0.711133919320731	p.Ala86Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.062	-3.709	1.647	9.431	9.431	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86P	86	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.062	-4.382	2.32	2.012	NA	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A86Q	86	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.062	-3.016	0.954	8.706	8.706	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.22	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A86R	86	A	R	missense	possibly_wt-like	0.805554533953803	0.243181127949092	5	0.108753906587849	0.592400793863587	1.01870827404402	NA	0.50877977842208	0.775462006780802	0.788363858049173	NA	1.1874453362165	NA	0.767721690300468	0.674379030201318	NA	0.542762438730317	0.674379030201318	0.641435465728993	NA	0.876601115271697	NA	0.679756270100405	p.Ala86Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.062	-2.912	0.85	10.5	10.5	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A86S	86	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.062	-2.566	0.504	12.879	12.879	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.08	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
A86T	86	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.062	-3.37	1.308	9.763	9.763	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A86V	86	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.062	-2.774	0.712	14.697	14.697	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.235	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A86W	86	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.062	-5.726	3.664	0.771	NA	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A86X	86	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A86Y	86	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala86Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.9	96.2	30.5	0.517	7.9	-141.6	-77.5	136.7	4.95867768595041	-5.9	0	1	35.69	0	0	0	0	4	17.9258940602694	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.062	-3.509	1.447	8.9	8.9	74.19	0.003442674	0	0.098397348	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q87A	87	Q	A	missense	possibly_wt-like	0.771007279709588	0.30853991777153	8	0.109085334061494	0.557203953707538	0.984810605711637	0.499760868238531	0.832248616025421	0.870162355274456	0.651772389402607	1.03462680197922	1.09732032327694	0.993751872995134	0.188415010484387	0.706350589165785	0.54488720132711	0.691876129027578	0.720825049303992	0.581533066638374	0.766601453177736	0.83218095770938	0.822815465234802	0.388800615775572	p.Gln87Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.944	-3.201	0.257	14.447	14.447	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q87C	87	Q	C	missense	possibly_wt-like	0.778994295807412	0.268458153159461	7	0.101467644383946	0.58012136721876	0.977867224396064	NA	0.933634673235865	0.89683951661409	0.625824052023995	0.357086040768897	1.19819313881746	0.647808900606667	0.793573748584917	0.692740416142331	NA	0.738613395118964	0.733908928771118	0.570153383289236	0.51351434911087	0.881898413651044	0.636492865990274	0.692740416142331	p.Gln87Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.944	-3.212	0.268	14.391	14.391	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.06	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q87D	87	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.944	-2.521	-0.423	13.585	13.585	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.725	Neutral	TOLERATED	neutral	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q87E	87	Q	E	missense	possibly_wt-like	0.904256867854281	0.465402681693551	6	0.18999984917869	0.531864006396008	1.27664972931256	NA	0.970473138797865	0.556870454833607	0.289763913894308	1.65945922740996	NA	0.982840755034222	0.966133717155727	0.767501816417493	NA	0.755595307767917	0.567170265303234	0.422773691774372	1	NA	0.816938809192031	0.77940832506707	p.Gln87Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.944	-2.434	-0.51	10.909	10.909	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	-0.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
Q87F	87	Q	F	missense	possibly_wt-like	1.03404208161327	0.522980518777415	7	0.197668056173798	0.646619810618585	1.42146435260795	NA	1.12640756335204	1.0839448619792	1.07250839108472	1.65945922740996	-0.0528368269189065	1.26576804761438	1.0830433067715	0.827478453179796	NA	0.827478453179796	0.825675206121436	0.76604748861715	1	0.265299909188578	0.969321579643448	0.838125939292238	p.Gln87Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.944	-3.899	0.955	10.234	10.234	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q87G	87	Q	G	missense	possibly_wt-like	0.760043440356898	0.213829511742811	8	0.0756001488855749	0.611869871315306	0.908217009398491	1.12232983275985	0.754852147560946	0.787303539319172	0.824888965008056	0.866225967542739	0.560454758412408	0.768465408255069	0.395826903996949	0.668820173335562	0.841090896017078	0.656197659613886	0.680186738992578	0.657453607678546	0.703697371312847	0.567574582595078	0.701477663818666	0.492972836283817	p.Gln87Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.944	-3.491	0.547	16.447	16.447	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q87H	87	Q	H	missense	wt-like	1.18498074289734	0.0683081788306591	3	0.0394377454357341	1.10768418221184	1.26227730358284	NA	1.24392069384827	1.11011727745263	1.20090425739112	NA	NA	NA	NA	0.83851153173563	NA	0.881650028644398	0.83851153173563	0.822355693670372	NA	NA	NA	NA	p.Gln87His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.944	-3.149	0.205	19.327	19.327	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-1.48	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
Q87I	87	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.944	-3.27	0.326	9.904	9.904	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.235	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q87K	87	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.944	-3.112	0.168	10.863	10.863	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.235	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
Q87L	87	Q	L	missense	wt-like	1.10165851336129	0.134419386431667	6	0.0548764847159295	0.994102579719906	1.20921444700267	NA	0.964022269393825	1.05833961488644	1.11658813773286	1.09742203206422	1.35229960179021	1.02127942430018	NA	0.801587448322361	NA	0.752621565537941	0.813117049636104	0.785378729445687	0.790057847008617	0.957853280600271	0.837641622490092	NA	p.Gln87Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.944	-3.199	0.255	11.554	11.554	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
Q87M	87	Q	M	missense	wt-like	1.21099492453088	0.404226311959419	3	0.2333801700233	0.753578196579381	1.66841165248239	NA	NA	NA	NA	1.65945922740996	0.874696997482992	NA	1.0988285486997	0.84605404637941	NA	NA	NA	NA	1	0.722456000272239	NA	0.84605404637941	p.Gln87Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.944	-5.03	2.086	1.739	NA	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q87N	87	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.944	-2.879	-0.065	16.268	16.268	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.625	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q87P	87	Q	P	missense	possibly_low	0.698683982594101	0.11858504479399	5	0.0530328442548439	0.594741517856886	0.802626447331317	NA	0.743276240921499	0.694653382174503	0.718780260827363	0.507107715095929	NA	NA	0.829602313951214	0.634746241285271	NA	0.650861361470504	0.634746241285271	0.610919471924672	0.569553119434984	NA	NA	0.710835693092813	p.Gln87Pro	1	0	NA	NA	NA	NA	NA	NA	NA	-1.141	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.944	-3.81	0.866	10.189	10.189	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.04	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Q87Q	87	Q	Q	synonymous	wt-like	0.864489446042461	0.124692460564122	5	0.0557641636206177	0.755193693718052	0.97378519836687	NA	0.734575571317688	0.965015024296562	0.841764808101265	0.761442187468019	NA	NA	1.01964963902877	0.664854534676232	NA	0.64685049921158	0.767345774384911	0.664854534676232	0.664556665733869	NA	NA	0.80628659284453	p.Gln87=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	NA	NA	NA	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q87R	87	Q	R	missense	possibly_wt-like	0.90037871841696	0.465095171401493	7	0.175789451357901	0.555837724893417	1.2449197119405	0.672544951151	1.12611949934804	1.11480683851372	1.25522259965816	-0.0419684295887951	NA	1.26786091578192	0.908064654054684	0.827345660521942	0.62709381080955	0.827345660521942	0.840811538505311	0.846177086387367	0.364452409151196	NA	0.970448784610668	0.750243250954757	p.Gln87Arg	1	0	NA	NA	NA	NA	NA	NA	NA	1.345	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.944	-2.271	-0.673	14.854	14.854	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	-1.405	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.5
Q87S	87	Q	S	missense	wt-like	0.887436909904351	0.178448586277177	6	0.0728513302833506	0.744650926323152	1.03022289348555	NA	0.901335222879525	0.943194628546714	0.803940842276712	0.719741341698875	NA	0.749790156077253	1.20661926794703	0.707571594237685	NA	0.723723892090195	0.756643907560278	0.64826677616933	0.648979822395324	NA	0.691419296385174	0.900191725680308	p.Gln87Ser	0	0	NA	NA	NA	NA	NA	NA	NA	-0.3735	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.944	-2.807	-0.137	11.242	11.242	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	-0.71	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q87T	87	Q	T	missense	wt-like	1.00880132253106	0.24529080695778	7	0.0927112105858053	0.827090688819769	1.19051195624234	NA	0.849793934860847	0.569600463629652	0.929206676072592	1.24495509508519	1.22500803094255	1.18695700990649	1.05608804722007	0.824587712557528	NA	0.699964225730731	0.573413729462797	0.703202300641038	0.845167026871673	0.895114741664357	0.926874475447317	0.824587712557528	p.Gln87Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.944	-2.891	-0.053	10.801	10.801	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-1.21	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q87V	87	Q	V	missense	wt-like	0.91261893195015	0.195126065645525	7	0.0737507205720745	0.768070175795007	1.05716768810529	0.506923098729842	1.00219528578902	1.07778612840947	0.895093502201263	0.920553709392536	NA	1.08033962915894	0.905441169969981	0.748925611170735	0.548294822417536	0.770218683661095	0.8226546400773	0.688241915664319	0.723990837982949	NA	0.869451058609642	0.748925611170735	p.Gln87Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.944	-2.613	-0.331	14.764	14.764	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.71	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q87W	87	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.944	-3.787	0.843	12.321	12.321	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.69	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q87X	87	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	0	1	0	1	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q87Y	87	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln87Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.4	92.8	29	0.873	33.8	156.2	-106.1	122.4	50	-0.6	0	1	30.45	1	12	0	0	6	15.6953183421044	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.944	-2.978	0.034	13.468	13.468	43.18	0.003006494	0	0.085930601	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.66	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y88A	88	Y	A	missense	low	0.28050070340094	0.157736662334579	3	0.0910693044599421	0.10200814656234	0.458993260239539	NA	0.431012820742809	0.116416543633543	NA	NA	NA	NA	0.294072745826468	0.44186700805452	NA	0.506913180023775	0.351148560010175	NA	NA	NA	NA	0.44186700805452	p.Tyr88Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.703	-3.191	1.488	6.398	5.391	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88C	88	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.703	-3.062	1.359	13.551	13.551	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	11	0	0	1	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y88D	88	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.703	-4.356	2.653	2.869	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y88E	88	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.703	-4.203	2.5	3.023	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88F	88	Y	F	missense	wt-like	0.977982431439545	0.128530404817017	2	0.0908847208347649	0.799851651858429	1.15611321102066	NA	1.06886715227431	NA	NA	NA	NA	NA	0.88709771060478	0.77033296819962	NA	0.800953292052705	NA	NA	NA	NA	NA	0.739712644346534	p.Tyr88Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.703	-1.861	0.158	33.954	33.954	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.275	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
Y88G	88	Y	G	missense	low	0.211957546694951	0.0816012162095358	4	0.0408006081047679	0.131989824262272	0.291925269127629	NA	0.18619203532641	0.18774875469984	0.33042633501291	0.143463061740643	NA	NA	NA	0.413886501883746	NA	0.394054918172661	0.386133618571425	0.440606259225125	0.43371808559483	NA	NA	NA	p.Tyr88Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.703	-4.015	2.312	3.924	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88H	88	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.703	-3.847	2.144	7.467	7.467	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	3	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y88I	88	Y	I	missense	low	0.455610179920513	0.122691943727222	4	0.0613459718636108	0.335374284471228	0.575846075369797	0.464543084318619	0.351042600801516	0.381828240394925	NA	0.625026794166991	NA	NA	NA	0.504725893455497	0.528131406691745	0.470048254494371	0.481320380219248	NA	0.613600356066203	NA	NA	NA	p.Tyr88Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.703	-2.424	0.721	20.146	20.146	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.05	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88K	88	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.703	-4.188	2.485	3.174	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88L	88	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.703	-2.57	0.867	13.604	13.604	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88M	88	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.703	-3.204	1.501	4.662	4.662	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88N	88	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.703	-4.447	2.744	3.22	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y88P	88	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.703	-4.537	2.834	1.705	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88Q	88	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.703	-4.532	2.829	1.937	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88R	88	Y	R	missense	low	0.294437160951915	0.0975692028755908	4	0.0487846014377954	0.198821099133695	0.390053222770135	NA	0.359818966615776	0.391528345047645	0.18439933530732	NA	NA	NA	0.24200199683692	0.444904293491077	NA	0.474094011432379	0.48607782043108	0.376565893446469	NA	NA	NA	0.415714575549775	p.Tyr88Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.703	-4.465	2.762	2.319	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88S	88	Y	S	missense	low	0.194245333374088	0.099984206746099	2	0.0706995106017244	0.0556768388701004	0.332813827878075	0.123545822772364	0.264944843975812	NA	NA	NA	NA	NA	NA	0.398125777118807	0.365892916652617	0.430358637584998	NA	NA	NA	NA	NA	NA	p.Tyr88Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.703	-3.466	1.763	12.879	12.879	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.915	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y88T	88	Y	T	missense	low	0.121107929085904	0.14934588563763	3	0.0862248872752488	-0.0478897445446095	0.290105602716418	NA	-0.0511886016444867	0.213550849373468	NA	NA	NA	NA	0.200961539528731	0.395102085609756	NA	0.284626439540508	0.398788319437501	NA	NA	NA	NA	0.395102085609756	p.Tyr88Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.703	-3.937	2.234	4.81	NA	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88V	88	Y	V	missense	low	0.363111860311474	0.0838171418647344	4	0.0419085709323672	0.280972570640492	0.445251149982456	NA	NA	NA	NA	0.420617998283413	0.238947434462915	0.404519233914995	0.388362774584574	0.497341325370842	NA	NA	NA	NA	0.537245938505322	0.409112402990689	0.505458658952171	0.489223991789512	p.Tyr88Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.703	-2.255	0.552	13.079	8.217	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.11	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y88W	88	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.703	-3.401	1.698	13.923	13.923	88.09	0.003558137	0	0.101697482	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y88X	88	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr88Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	90.1	30.8	0.594	29.2	-176.2	-135.5	65.8	13.7254901960784	-3	0	1	22.31	0	0	0	0	4	13.8100614719848	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	3	0	0	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P89A	89	P	A	missense	possibly_wt-like	0.906732714199711	0.333817445833015	8	0.118022289813449	0.675413276792403	1.13805215160702	0.15029684935448	1.10065909924342	1.08801523371776	1.18565884312846	0.953077679497526	0.777996215847783	0.890000402366008	1.10815739044225	0.791272226606271	0.378620426955776	0.81560884456102	0.827671529963231	0.815669793749152	0.736139771121562	0.674794825904186	0.766935608651522	0.850739439018345	p.Pro89Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.734	-2.726	0.992	15.885	15.885	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.745	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P89C	89	P	C	missense	wt-like	0.920290543595737	0.149185231989089	6	0.0609046159220003	0.800919689896372	1.0396613972951	0.803041679041871	1.03978688426385	0.885201590523508	1.16104671365466	NA	0.781365585651475	NA	0.851300808439058	0.724967399525967	0.689181089728035	0.78754777790797	0.728201079263522	0.804876106436041	NA	0.67645549626288	NA	0.721733719788412	p.Pro89Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.734	-5.413	3.679	1.175	NA	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89D	89	P	D	missense	wt-like	0.778194123209197	0.0259033395184045	2	0.0183164270288413	0.742294585907212	0.814093660511182	0.759877696180356	NA	0.796510550238038	NA	NA	NA	NA	NA	0.676673510195274	0.668644680222069	NA	0.68470234016848	NA	NA	NA	NA	NA	p.Pro89Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.734	-3.165	1.431	11.222	11.222	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.605	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89E	89	P	E	missense	possibly_wt-like	0.733078903435148	0.19083696175035	8	0.0674710548773552	0.600838065876607	0.86531974099369	0.793778315879186	0.917642317725221	0.791311888807802	0.91415742089369	0.632243819385563	0.32028650042266	0.744838352398074	0.750372611968993	0.683463221459368	0.684773799049561	0.731241188372847	0.682152643869175	0.69660242658832	0.61629618798823	0.449202207231015	0.688752287640689	0.671042729218277	p.Pro89Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.734	-2.873	1.139	9.214	9.214	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.605	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89F	89	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro89Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.734	-2.666	0.932	11.765	11.765	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.545	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89G	89	P	G	missense	wt-like	0.889200026163917	0.101277566372258	8	0.035807026981947	0.819019542885847	0.959380509441987	0.742634026640561	0.860065152715629	0.862106112413047	0.990682192448273	1.02187509152629	0.848526835989293	0.991672954709123	0.796037842869118	0.713215643767492	0.66044054715606	0.704699084301719	0.716873845155447	0.730162483094063	0.761838206956702	0.709557442379537	0.821695773581602	0.693978002708751	p.Pro89Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.734	-2.112	0.378	18.977	18.977	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.59	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P89H	89	P	H	missense	wt-like	1.04181089782372	0.125386933785076	3	0.0723921799736752	0.899924832312978	1.18369696333447	NA	0.945506865392379	NA	NA	1.18359001036904	NA	0.996335817709753	NA	0.822244846435051	NA	0.744086275899359	NA	NA	0.822244846435051	NA	0.824207160785684	NA	p.Pro89His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.734	-4.008	2.274	10.893	10.893	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P89I	89	P	I	missense	possibly_low	0.512727820015863	0.175433682155901	3	0.101286683617637	0.314209568011792	0.711246072019933	NA	0.378457953360784	0.44850188011207	0.711223626574734	NA	NA	NA	NA	0.514020630991344	NA	0.482686270635901	0.514020630991344	0.607605498326847	NA	NA	NA	NA	p.Pro89Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.734	-3.262	1.528	9.568	9.568	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89K	89	P	K	missense	wt-like	0.89119815920708	0.17198880750275	5	0.076915732989055	0.740446092704033	1.04195022571013	NA	0.725111977482543	0.791594042849651	1.10313714645235	1.04932217432339	NA	NA	0.786825454927469	0.689351098765045	NA	0.642487941721688	0.682291027013758	0.779479776488861	0.772090730639252	NA	NA	0.689351098765045	p.Pro89Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.734	-3.015	1.281	8.182	8.182	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89L	89	P	L	missense	wt-like	0.816759866372439	0.0469889075869677	8	0.0166130875976464	0.784198813009042	0.849320919735835	0.774603024476835	0.881199359025818	0.7789126314795	0.832700548742868	0.848735608231486	0.852750735444981	0.742673713118354	0.822503310459665	0.692375243859032	0.675650645658032	0.714441597731345	0.676071397581387	0.660879389764712	0.697164060491419	0.711639287066482	0.687586427226645	0.707270232382791	p.Pro89Leu	1	0	NA	NA	NA	NA	NA	NA	NA	6.41	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.734	-2.795	1.061	21.99	21.99	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P89M	89	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro89Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.734	-2.764	1.03	4.944	4.944	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89N	89	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro89Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.734	-4.196	2.462	1.962	NA	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89P	89	P	P	synonymous	wt-like	1.11584017874146	0.11036948011907	8	0.0390215039141141	1.0393594364472	1.19232092103571	1.24179362978357	1.06590946911248	0.927119284872883	1.02961340177062	1.24698433836572	1.17078417207993	1.16446016722103	1.08005696672541	0.841275540902524	0.897928965494774	0.799589849891605	0.74875971567257	0.747235824943414	0.845925025998397	0.868389282485452	0.914757824616084	0.836626055806652	p.Pro89=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P89Q	89	P	Q	missense	possibly_wt-like	0.859870045398151	0.354868096000429	8	0.125464818554331	0.61396351970481	1.10577657109149	0.582182083184794	0.946124919541746	0.953259240439008	1.09579799447551	1.18966729073835	0.0989345663939576	1.03647612475775	0.976518143654097	0.768920650661784	0.584101280054421	0.744371188460638	0.761580121245298	0.776261180078269	0.824514940542047	0.340103884073235	0.845826464950236	0.784623883098578	p.Pro89Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.734	-3.174	1.44	6.317	6.317	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89R	89	P	R	missense	wt-like	0.803431424684676	0.0960243930662488	8	0.0339497497482335	0.736891137893991	0.869971711475362	0.837165119468437	0.80722214147919	0.777791639827038	0.925368219584954	0.815209938979563	0.593111330719226	0.809344845348804	0.8622381620702	0.693079947231031	0.705416221425699	0.680339345446295	0.67552160446518	0.70151893963253	0.684640954829531	0.58367011523358	0.72349505854234	0.727226984397999	p.Pro89Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.734	-3.286	1.552	11.269	11.269	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P89S	89	P	S	missense	wt-like	0.835815422363613	0.100132034935115	8	0.0354020204583141	0.766428737285367	0.905202107441858	0.826067934896913	0.794786751446107	0.825421996894355	1.04965158450158	0.736685284836131	0.905986752970395	0.783183030824048	0.764740042539368	0.699509235975924	0.700136441581117	0.674606839923173	0.698882030370731	0.756023600863055	0.65530902610614	0.737877866228242	0.709404478093341	0.678258743305837	p.Pro89Ser	1	0	NA	NA	NA	NA	NA	NA	NA	-0.205	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.734	-3.388	1.654	5.73	5.73	58.56	0.002823947	0	0.080713117	0	NA	NA	Cowden syndrome 1|not specified	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.095	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P89T	89	P	T	missense	wt-like	0.868036496920624	0.10500596853071	8	0.037125216206563	0.795272410237497	0.94080058360375	0.678717215952286	0.830495957721029	0.841710656507627	0.975701953105168	0.999786457223969	0.932619739288527	0.793498725667865	0.891761269898516	0.719276659610886	0.630030429470186	0.69106818304572	0.706870843586194	0.723592876042501	0.753587266484308	0.751004537837154	0.714960443179271	0.742054907940357	p.Pro89Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.734	-3.95	2.216	2.747	NA	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P89V	89	P	V	missense	possibly_wt-like	0.767543361339375	0.126805167176204	8	0.044832396799894	0.679673478270974	0.855413244407776	0.830933437560258	0.820147711768226	0.825608018343178	0.8946481002382	0.776482274013398	0.846302765767837	0.6197726852794	0.526451897744506	0.687172199882428	0.702451333500785	0.686297815817893	0.698973265048354	0.688046583946962	0.670174706989254	0.708461258906776	0.621392745653418	0.558578985584674	p.Pro89Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.734	-3.817	2.083	6.211	NA	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89W	89	P	W	missense	low	0.455914833757723	0.235169536899481	8	0.0831449871350616	0.292953653477956	0.61887601403749	0.588423518937337	0.526806197744437	0.548947069539804	0.622648498502261	0.118575255459002	0.722782121244628	0.441190460980465	0.0779455476538513	0.557178268068549	0.587070808629451	0.551072314661237	0.563284221475861	0.568760739398095	0.424421548502145	0.647581306572124	0.525209539558736	0.333317542714899	p.Pro89Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.734	-5.609	3.875	0.757	NA	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P89X	89	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro89Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P89Y	89	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro89Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.3	87.9	27.7	0.405	11.8	158	-73.4	143.1	42.8571428571429	-0.5	0	1	23.67	0	0	0	0	7	11.5214850544537	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.734	-3.759	2.025	8.742	8.742	58.56	0.002823947	0	0.080713117	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90A	90	F	A	missense	wt-like	0.811603976378254	0.123854192855594	8	0.0437890698232884	0.7257789766081	0.897428976148409	0.841575185968897	0.715070815607783	0.786184740310767	0.976865941658347	0.986476435254834	0.836915669581258	0.692074064405771	0.657668958238379	0.691736318411105	0.707514427513228	0.63785913508575	0.679638021264048	0.724103345016444	0.748615469792376	0.703834615558162	0.660333790747585	0.624482499258462	p.Phe90Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.505	-3.601	2.096	2.616	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90C	90	F	C	missense	wt-like	1.08530431080475	0.0743803677138679	4	0.0371901838569339	1.01241288986674	1.15819573174277	NA	1.13466328588523	0.993508084367891	1.05735993442161	NA	NA	NA	1.15568593854428	0.806302234091888	NA	0.831284202327428	0.781320265856347	0.759404109600644	NA	NA	NA	0.874610559952988	p.Phe90Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.505	-5.173	3.668	0.929	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F90D	90	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe90Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.505	-4.347	2.842	1.07	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90E	90	F	E	missense	possibly_low	0.594301154918862	0.226336318546857	6	0.0924014151166389	0.413197709169715	0.775404600668009	0.492828484815857	0.358241953908672	0.74258065857323	0.861522194456962	0.771749884997379	NA	NA	0.338883752761075	0.599920614041448	0.54158893607487	0.473367035114832	0.658252292008026	0.673519166912737	0.668406980676755	NA	NA	0.464373249218099	p.Phe90Glu	0	0	NA	NA	NA	NA	NA	NA	NA	15.813	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.505	-4.232	2.727	1.186	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90G	90	F	G	missense	wt-like	0.90446501110713	0.112991006076472	8	0.039948353304882	0.82616767738788	0.982762344826381	0.965704697845373	0.921569691337842	0.931277593776616	1.01883468900082	0.753398423374097	0.785394757782396	0.800837908864532	1.05870232687536	0.737780222679147	0.766572334561557	0.733051641512299	0.750799168513555	0.742508803845995	0.661552015568333	0.678441365169454	0.718913278758192	0.825900729434766	p.Phe90Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.505	-3.99	2.485	1.463	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90H	90	F	H	missense	possibly_low	0.651007206834956	0.143672728419512	4	0.0718363642097558	0.510210520203533	0.79180389346638	NA	0.532144123969569	0.604360537480735	0.607420333304121	0.8601038325854	NA	NA	NA	0.576272148677351	NA	0.553533008816079	0.590461893274	0.562082404080703	0.701410522320483	NA	NA	NA	p.Phe90His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.505	-5.048	3.543	0.982	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90I	90	F	I	missense	wt-like	1.05397778087805	0.133797733611295	3	0.0772481575174432	0.902574174271785	1.20538138748432	NA	NA	NA	NA	NA	1.08245985945794	0.908232323718037	1.17124115945818	0.824856640932505	NA	NA	NA	NA	NA	0.824856640932505	0.776755201031382	0.882423139432664	p.Phe90Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.505	-1.855	0.35	10.107	10.107	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F90K	90	F	K	missense	low	0.193023140500112	0.240797611491611	7	0.0910129423293075	0.0146410514076486	0.371405229592576	NA	0.433818687701813	0.304391394628392	0.494897260487744	-0.200080096630006	0.12353818618108	0.0313332967889367	0.163263254342826	0.3761681951242	NA	0.508206637470372	0.443341288537613	0.512735237075783	0.305391720523162	0.352230336341046	0.304463178897292	0.3761681951242	p.Phe90Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.505	-4.213	2.708	1.459	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90L	90	F	L	missense	wt-like	1.05101444689606	0.144319844483849	7	0.0545477739651116	0.944102774487607	1.15792611930451	NA	1.03074033167746	1.03219732439805	1.03763574150223	1.34892074283539	1.03311317425376	0.869902759374167	1.00459105423133	0.798723447889365	NA	0.783377469415135	0.800295498895002	0.750754034396794	0.884002129079444	0.800535007454154	0.756111150923491	0.798723447889365	p.Phe90Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.505	-2.785	1.28	21.99	21.99	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F90M	90	F	M	missense	possibly_wt-like	0.907202090765505	0.327700373666259	8	0.115859578208389	0.680121490213061	1.13428269131795	0.334422327639643	1.11434647050164	1.14475592253945	1.165423361676	0.716511564526868	1.05962174692317	1.17255746229305	0.54997787002421	0.810197925572233	0.466223006047647	0.821918492358636	0.855500140510403	0.806795492171119	0.647773378446794	0.813600358973347	0.919118974242139	0.570394859450382	p.Phe90Met	0	0	NA	NA	NA	NA	NA	NA	NA	9.909	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.505	-2.703	1.198	5.024	5.024	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90N	90	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe90Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.505	-4.494	2.989	1.201	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90P	90	F	P	missense	low	0.379119146479766	0.170311591189669	8	0.0602142405224432	0.261101403699345	0.497136889260187	0.334492086225654	0.516582561032666	0.420902002721315	0.610276370232919	0.367801957733065	0.461140334797598	0.0493847728150412	0.27237308627987	0.509000676309769	0.46625619554486	0.546359390196408	0.50048420316491	0.56333492347757	0.517517149454627	0.518625215473884	0.314185584616831	0.430968396210426	p.Phe90Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.505	-4.56	3.055	0.838	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90Q	90	F	Q	missense	possibly_wt-like	0.83204178695357	0.270059634055498	8	0.0954804992827002	0.644903447133575	1.01918012677356	0.737531590293559	0.732039746052772	0.806749651967968	0.912198749212436	1.43754536846696	0.502999666482832	0.752109160416875	0.775160362735158	0.686608230850576	0.658012927753181	0.645681526441274	0.68972413282402	0.695743448103789	0.917106779211543	0.539256536882497	0.692668296800573	0.683492328877132	p.Phe90Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.505	-4.58	3.075	0.958	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90R	90	F	R	missense	low	0.268502782589751	0.146488568074615	8	0.0517915299259337	0.166993249230693	0.37001231594881	0.324955288596819	0.252763570661282	0.428455415142835	0.490692168440614	0.0520736420710388	0.155343303831465	0.159304472011361	0.284434399962595	0.430884721582242	0.461718811167945	0.424743275592458	0.504188792886075	0.510891087477599	0.399580680303945	0.367906210232633	0.373387608352226	0.437026167572027	p.Phe90Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.505	-4.489	2.984	1.432	NA	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90S	90	F	S	missense	wt-like	1.00697877865304	0.322846298130467	7	0.122024430935862	0.767815288784752	1.24614226852132	1.09642389584498	0.834749603209152	0.674929265516541	0.843093539327742	1.6566767228559	1.08544838704578	NA	0.857530036771149	0.7248623376146	0.828765459533926	0.693029042028767	0.625072499702995	0.665437251803453	0.998960629293534	0.826329604563816	NA	0.7248623376146	p.Phe90Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.505	-3.432	1.927	4.802	4.802	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F90T	90	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe90Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.505	-3.369	1.864	5.431	5.431	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F90V	90	F	V	missense	wt-like	0.96638399826933	0.185195326502378	8	0.065476435606944	0.838052542643664	1.094715453895	1.19494506792773	0.701869034015893	0.888387589235307	0.761172254813532	1.12551103396972	1.0973251994086	1.09666183662201	0.865199970161842	0.765156905968574	0.875639519821425	0.63177333595205	0.72976366017672	0.629510546222125	0.800550151760428	0.832183361021506	0.878242091706603	0.728714546757131	p.Phe90Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.505	-2.566	1.061	8.017	8.017	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F90W	90	F	W	missense	possibly_low	0.675532636768049	0.455373691938434	7	0.172115077495776	0.338193283680007	1.01287198985609	1.14248634248261	0.893929359075308	0.770241407394053	0.796530277322861	-0.0610550343730182	0.146782838488663	NA	1.03981326698586	0.671818574377223	0.850680890045335	0.720309913513873	0.671818574377223	0.645016861487608	0.357322840263446	0.363686990651616	NA	0.816413735807357	p.Phe90Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.505	-2.215	0.71	14.416	14.416	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.6	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F90X	90	F	X	nonsense	low	-0.00276767192431047	0.14130947286819	4	0.0706547364340949	-0.141248410672306	0.135713066823685	NA	-0.0965319656016101	NA	NA	0.205924883095571	-0.0821009983937252	-0.0383626067974777	NA	0.265324668789685	NA	0.263723911865092	NA	NA	0.457049938652971	0.250876398273645	0.266925425714277	NA	p.Phe90Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F90Y	90	F	Y	missense	possibly_low	0.56944207220511	0.271907055770771	8	0.0961336614939905	0.381023557974924	0.757860586435297	0.795853123632163	0.817354048158679	0.601573675112023	0.70671620861282	-0.0322690538488526	0.498084216619293	0.490954942957095	0.677269416397662	0.597361916497932	0.685760943859575	0.685009983910018	0.589095069763077	0.605628763232788	0.36807549289437	0.536833845885776	0.552012360751852	0.634326791284598	p.Phe90Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.1	84.9	27.8	0.961	43	-66.4	-154.5	164.5	5.26315789473684	-3.6	0	1	21.14	0	0	0	0	5	9.83755954797734	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.505	-3.336	1.831	6.616	6.616	58.56	0.002295115	0	0.065598209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E91A	91	E	A	missense	wt-like	0.926546533135416	0.143908013378272	8	0.0508791660634303	0.82682520008766	1.02626786618317	0.780489811451071	1.03787960520335	0.905730344812162	0.948805169141674	1.14065063252718	0.702814012970343	1.03013784954818	0.865864839429367	0.73365896670397	0.678451440671902	0.786668554359743	0.738269457353058	0.71179724998181	0.806205364516626	0.637739571333095	0.842412711800058	0.729048476054882	p.Glu91Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.998	-3.216	1.218	6.469	6.469	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.54	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
E91C	91	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu91Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.998	-5.486	3.488	0.727	NA	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E91D	91	E	D	missense	low	0.340525531912428	0.445873140701059	7	0.168524206654045	0.0102241563473146	0.670826907477541	NA	0.474933048490807	0.465677756438051	0.502681023669068	-0.348369550675429	0.0670433269568041	0.143273624182224	1.07843949432547	0.516148818415339	NA	0.527159665857538	0.522444581828179	0.516148818415339	0.25	0.324385563104937	0.364753499629056	0.835813683436587	p.Glu91Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.998	-1.732	-0.266	21.657	21.657	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-1.12	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
E91F	91	E	F	missense	wt-like	0.816755313143309	0.0911425198484302	6	0.0372087779166903	0.743827448517847	0.889683177768771	NA	0.916613948458999	0.774854334779714	NA	0.727838744820433	0.925448030026402	0.83732669981918	0.718450120955124	0.702424061710106	NA	0.73076712744812	0.674080995972092	NA	0.652004508766718	0.747469798201351	0.738565900480843	0.655009720133059	p.Glu91Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.998	-4.618	2.62	3.03	NA	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E91G	91	E	G	missense	wt-like	0.844324386521269	0.111219808662062	8	0.0393221404536073	0.767254407437173	0.921394365605364	0.82785055174371	0.847836478072026	0.776784557428835	0.885842736593265	0.63488803946886	0.943662180820928	0.831757500876859	1.00597304716566	0.700023219956583	0.700984568818947	0.699061871094219	0.675027678423208	0.684184978149592	0.617283904213896	0.756447055699214	0.735566366726829	0.799417551155373	p.Glu91Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.998	-3.136	1.138	14.802	14.802	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.235	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E91H	91	E	H	missense	wt-like	1.11744439500426	0.0789432604275256	4	0.0394716302137628	1.04008142137421	1.19480736863432	NA	1.14322055280092	1.13107751000918	1.19012292150105	NA	NA	NA	1.00535659570592	0.826428240280023	NA	0.835228958360531	0.848791529404098	0.817627522199516	NA	NA	NA	0.799107939607503	p.Glu91His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.998	-3.93	1.932	6.589	6.589	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E91I	91	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu91Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.998	-4.266	2.268	6.397	NA	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.685	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E91K	91	E	K	missense	wt-like	0.998900889078742	0.12367162809719	5	0.0553076334626778	0.890499919421751	1.10730185873573	NA	1.12064221376172	0.99314304014804	1.10794091421397	0.818872220874928	NA	NA	0.953906056395052	0.78114122901986	NA	0.824820724046949	0.78114122901986	0.781586476244321	0.68600895565286	NA	NA	0.773267006208786	p.Glu91Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.998	-2.674	0.676	20.007	20.007	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E91L	91	E	L	missense	possibly_wt-like	0.72942987142504	0.324411373660712	8	0.114696741104766	0.504628389715584	0.954231353134497	0.961710361541985	1.05350068850178	0.905671283482519	0.985567200997648	0.46580888755739	0.162723476201171	0.452924426595993	0.847532646521836	0.723880231748644	0.764671923139976	0.793869610864378	0.738240490578506	0.727919295710132	0.554126445112964	0.371543695641032	0.531529375911637	0.719841167787155	p.Glu91Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.998	-3.11	1.112	8.945	8.945	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.76	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E91M	91	E	M	missense	wt-like	0.975281522332549	0.145342791796611	7	0.054934411707096	0.867612053874745	1.08295099079035	1.14119843711245	1.12488903832576	0.79654552147649	1.11207171224726	0.907143252719429	NA	0.887267208603785	0.857855485842666	0.765463528549706	0.850068134911699	0.826778438698786	0.68471949189849	0.783398044088233	0.718981525129877	NA	0.765463528549706	0.72502579377841	p.Glu91Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.998	-3.743	1.745	4.944	4.944	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E91N	91	E	N	missense	wt-like	0.862334120245513	0.167144441052436	7	0.063174660578806	0.738514060775511	0.986154179715515	NA	0.984919332862874	0.843120515539407	1.01115416365067	1.02307801583335	0.578021029303911	0.885015653550899	0.711030130977472	0.739140497616412	NA	0.762254760108811	0.707562312419875	0.739140497616412	0.762287544689153	0.576232517782352	0.764250855874497	0.651283044584079	p.Glu91Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.998	-2.862	0.864	13.439	13.439	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.54	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
E91P	91	E	P	missense	possibly_wt-like	0.709270284034213	0.294188742752121	7	0.111192893119553	0.491336218183078	0.927204349885348	0.858125719526305	0.846925453646418	0.820707122144418	0.652256151578007	0.328857597652195	NA	0.330881029744398	1.12713891394775	0.696569608440025	0.71538878275444	0.698641904166153	0.696569608440025	0.581745221285973	0.502969957791947	NA	0.465797608721737	0.860272872317232	p.Glu91Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.998	-2.257	0.259	13.872	13.872	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.005	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
E91Q	91	E	Q	missense	wt-like	1.11212070560808	0.0905300644650873	6	0.0369587440534552	1.03968289834948	1.18455851286669	NA	1.06539006055866	1.07216732027147	1.15856363275944	1.11822734359377	1.26037791365921	0.997997962805944	NA	0.811843014636565	NA	0.79935041128971	0.819898881790628	0.803787147482502	0.797829417880334	0.912547590903319	0.825102381152514	NA	p.Glu91Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.998	-3.218	1.22	8.918	8.918	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.735	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E91R	91	E	R	missense	possibly_wt-like	0.803317311438538	0.180705191094192	8	0.0638889330091569	0.678097303729898	0.928537319147178	0.42486352942048	0.667293545220389	0.899279398111188	0.846303955722886	1.0170179896499	0.83798420482582	0.887385665811871	0.846410202745771	0.711819344990033	0.509252806192411	0.615834617507551	0.735105574659175	0.666845184861458	0.760023895673262	0.704361267398492	0.765527328819321	0.719277422581574	p.Glu91Arg	0	0	NA	NA	NA	NA	NA	NA	NA	2.816	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.998	-3.576	1.578	8.452	8.452	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.43	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E91S	91	E	S	missense	possibly_low	0.697597772087328	0.356120043337181	8	0.125907448780084	0.450823707093042	0.944371837081614	0.867240347112918	0.699123757900734	0.689090572497034	0.955736200369406	0.97425891919873	-0.00470311320977064	0.366489630651715	1.03354586217786	0.67342740599517	0.7197253085383	0.630507809864748	0.632017947581456	0.714836864408883	0.74405176538586	0.289023702143296	0.48497616590041	0.813265943920318	p.Glu91Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.998	-3.018	1.02	7.695	7.695	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.34	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E91T	91	E	T	missense	wt-like	1.04297517198033	0.217674340307966	6	0.0888651773085763	0.868802624975759	1.21714771898491	NA	0.888089912468226	0.924035526190929	1.14342541529565	1.4453170609488	NA	0.911283033405545	0.945700083572861	0.773771932708011	NA	0.717618026903319	0.74724727863376	0.797148258882637	0.920009800338143	NA	0.778398293112694	0.769145572303328	p.Glu91Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.998	-3.089	1.091	7.261	7.261	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.26	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E91V	91	E	V	missense	possibly_low	0.682882558058245	0.10568069727375	8	0.0373637688413957	0.60965091680243	0.75611419931406	0.876842958678489	0.756413087089899	0.709083412930663	0.600954003456415	0.714838328285502	0.536728504675447	0.651579814083061	0.616620355266485	0.640173670237505	0.724294005640928	0.656917226466809	0.641823485401196	0.559246585160042	0.647148361416098	0.55588056009251	0.638523855073813	0.603865918174675	p.Glu91Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.998	-3.296	1.298	10.489	10.489	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.685	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
E91W	91	E	W	missense	possibly_wt-like	0.768663158007578	0.147401480353414	8	0.0521142931574174	0.666521020339278	0.870805295675879	0.946559492823064	0.542661845070362	0.880649876322056	0.944065108439693	0.634031472455488	0.709221265646612	0.787160411322323	0.70495579198103	0.678975354340654	0.757463495563189	0.558381501234937	0.725968679825576	0.709718489055544	0.616963944032509	0.640897531195052	0.711546668950714	0.648232219625765	p.Glu91Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.998	-5.776	3.778	0.634	NA	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E91X	91	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu91Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E91Y	91	E	Y	missense	wt-like	0.980845300548997	0.126672592147492	3	0.0731344551753021	0.837504402376446	1.12418619872155	NA	1.00140263187236	0.845151353928369	NA	NA	NA	NA	1.09598191584626	0.769853283545533	NA	0.769853283545533	0.708558342108346	NA	NA	NA	NA	0.844624330559874	p.Glu91Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.8	82.9	25.4	0.277	51.4	-96.8	-67.2	140	39.2523364485981	-3.4	0	0	31.34	0	0	0	0	5	8.25670381326592	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.998	-3.571	1.573	7.325	7.325	72.21	0.003168641	0	0.090565038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.54	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D92A	92	D	A	missense	wt-like	1.04452681930451	0.0750546800090594	8	0.0265358365970961	0.99251753527456	1.09653610333446	1.02866161526016	1.02784002082228	1.11080631418587	1.11800786753538	1.07463850646804	0.887743461160722	1.01282950998181	1.09568725902182	0.791263555852985	0.796525757567292	0.782040474921847	0.838849471498086	0.786001354138678	0.781547338351883	0.728886245919854	0.833090554467742	0.844476339742329	p.Asp92Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-0.748	-3.487	2.739	1.474	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Mar 29, 2016)	criteria provided, single submitter	0	1	0	0	0	1	0	0	1	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D92C	92	D	C	missense	possibly_wt-like	0.820916678513636	0.170420672620078	5	0.0762144417499462	0.671539117581916	0.970294239445357	NA	0.810220136652676	0.804855022394092	0.742990134226704	0.644951761235738	NA	NA	1.10156633805897	0.681721370766335	NA	0.681721370766335	0.6887949070843	0.621536749216368	0.621043084980473	NA	NA	0.847429095765486	p.Asp92Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-0.748	-5.318	4.57	0.246	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92D	92	D	D	synonymous	wt-like	0.914596997820855	0.2427439744381	6	0.0990998125847578	0.720364934280061	1.10882906136165	NA	0.763510690864121	1.08283310331671	1.07146059896552	1.1618543941909	0.518198612280135	0.889724587307749	NA	0.766187517125948	NA	0.660189102357184	0.825129941347898	0.76558797776841	0.814125771585876	0.546747682182528	0.766787056483485	NA	p.Asp92=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D92E	92	D	E	missense	wt-like	0.981943007533983	0.205301083470202	8	0.0725848941533626	0.839679229171741	1.12420678589623	1.108582162011	1.07806868268267	1.07116747555987	0.991514552107573	1.03084390172906	0.49030071272625	0.970896369826037	1.1141702036294	0.807850342475025	0.834550077085764	0.805195042713259	0.819408505489876	0.730527515705487	0.765188396836184	0.532997569384514	0.810505642236792	0.853759362758492	p.Asp92Glu	1	0	NA	NA	NA	NA	NA	NA	NA	1.602	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-0.748	-2.609	1.861	7.961	7.961	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	13	5	3	3	0	1	2	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.44	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D92F	92	D	F	missense	possibly_low	0.679754039088228	0.053501822502533	5	0.0239267424071584	0.63285848570283	0.726649592473625	NA	0.585028868506696	0.702754885303463	0.694383885650953	NA	0.701091525297558	0.71551103068247	NA	0.636890604200346	NA	0.577911986020767	0.638719643443482	0.600220403991204	NA	0.636890604200346	0.672956785933558	NA	p.Asp92Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-0.748	-4.523	3.775	0.421	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92G	92	D	G	missense	possibly_low	0.640134050768005	0.206794481891446	8	0.0731128902287	0.496835419114123	0.783432682421887	0.775894532048593	0.692473665107526	0.74271628160416	0.83087494038162	0.344782345172938	0.703510884551896	0.282053211346386	0.74876654593092	0.648200924480782	0.676265114634604	0.627442229005208	0.658318808657495	0.660078766404246	0.508918453386251	0.638083040304068	0.439499268343424	0.670236085671297	p.Asp92Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-0.748	-3.372	2.624	1.605	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	2	2	1	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D92H	92	D	H	missense	wt-like	0.999658654254048	0.132111400103425	6	0.0539342532430107	0.893949460364685	1.10536784814341	NA	0.980042098600635	1.11903286479471	1.17272354840161	0.861544526625959	1.01754513088017	0.847063756221205	NA	0.776434190617225	NA	0.76000643719562	0.842884203500715	0.809997000310731	0.701948676042659	0.792861944038829	0.743810214725153	NA	p.Asp92His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-0.748	-4.634	3.886	0.803	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	3	0	2	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D92I	92	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp92Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-0.748	-4.231	3.483	0.602	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92K	92	D	K	missense	possibly_low	0.470509928033672	0.412360025571453	2	0.291582570371832	-0.100981408414735	1.04200126448208	NA	0.762092498405505	NA	NA	0.17892735766184	NA	NA	NA	0.553250340576321	NA	0.659535339501316	NA	NA	0.446965341651326	NA	NA	NA	p.Asp92Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-0.748	-3.611	2.863	2.086	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D92L	92	D	L	missense	wt-like	0.932224533003858	0.0797161252436067	7	0.0301298632680374	0.873171086139388	0.991277979868327	0.902968367763297	0.848128766017671	1.0285279928919	0.864273899212583	1.01359586744205	NA	0.864466790068587	1.00361004763092	0.753183373771563	0.736723861829081	0.699196610918084	0.798495866222688	0.67472593127426	0.75874560357789	NA	0.753183373771563	0.798230739230435	p.Asp92Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-0.748	-3.965	3.217	1.089	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D92M	92	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp92Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-0.748	-5.069	4.321	0.498	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92N	92	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp92Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-0.748	-2.871	2.123	7.938	7.938	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	1	0	2	1	1	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D92P	92	D	P	missense	wt-like	1.05306879336959	0.186224645165788	5	0.0832821931352961	0.889838694270904	1.21629889246828	1.01616745208124	1.08279902402256	1.16483055830874	1.24419961896098	NA	NA	NA	0.757347313474442	0.80737565046139	0.790581328103965	0.80737565046139	0.865345795053925	0.841342941213931	NA	NA	NA	0.674545759497304	p.Asp92Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-0.748	-3.025	2.277	11.049	11.049	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92Q	92	D	Q	missense	wt-like	1.05252782851376	0.109266870876133	7	0.0412989952680648	0.971583285190668	1.13347237183686	1.02413687883312	1.14941180522054	0.924235237719595	1.09796239225685	1.22625610448446	NA	0.977307933084325	0.968384447997461	0.794372994221281	0.794372994221281	0.838083021529929	0.747345227644751	0.777210380061063	0.838182246543979	NA	0.81395886784579	0.780538750259083	p.Asp92Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-0.748	-3.088	2.34	4.937	4.937	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D92R	92	D	R	missense	wt-like	1.081705358721	0.117382469209843	8	0.0415009699853505	1.00036495222624	1.16304576521577	1.01608935381603	1.14250857481989	0.978335205866996	1.22019004017257	0.993923406230971	1.25428789885861	0.939095554567707	1.10921283543524	0.812095718341375	0.790544170783214	0.834900748493554	0.773878690234877	0.830813503432553	0.751397195153155	0.909545988926509	0.793377933250197	0.851269534215311	p.Asp92Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-0.748	-4.055	3.307	1.674	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92S	92	D	S	missense	wt-like	0.867702336533336	0.138828062971047	8	0.0490831323729101	0.77150116483402	0.963903508232652	1.07621445787537	0.762543185666738	0.742371502948715	0.870569546956949	0.864371299101515	0.67331076244981	0.935171961045773	1.01706597622182	0.6902457398939	0.819150283488636	0.659743098743876	0.658149711116972	0.677486897295445	0.703004582492356	0.623198224885783	0.791264711702904	0.804988953219884	p.Asp92Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-0.748	-3.379	2.631	1.766	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D92T	92	D	T	missense	possibly_wt-like	0.896673232982054	0.3702511901539	3	0.213764624303134	0.477702268179176	1.31564419778493	0.469591221217972	1.12714528227667	1.09328319545152	NA	NA	NA	NA	NA	0.827818529188565	0.530533191692446	0.827818529188565	0.830255214767042	NA	NA	NA	NA	NA	p.Asp92Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-0.748	-3.63	2.882	1.255	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.585	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D92V	92	D	V	missense	possibly_wt-like	0.751959352629466	0.172585267417865	8	0.061018106462033	0.63236606155905	0.871552643699881	0.907554014648495	0.80996527086762	0.765091042506667	0.738481357879628	0.498674236885393	0.487368116353118	0.90672617271565	0.901814609179155	0.675448223582493	0.738905604940839	0.681603881928704	0.669292565236282	0.619559418400403	0.566402896304936	0.531552172721453	0.775943998052804	0.747104178060074	p.Asp92Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-0.748	-3.938	3.19	0.838	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	1	0	0	1	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D92W	92	D	W	missense	possibly_low	0.64090200513675	0.338197036292421	8	0.119570708869782	0.406547722146054	0.875256288127446	0.226695771638237	0.825936125262784	0.850427317963705	0.925180404616802	0.554336262753557	0.0330454708422809	0.836074951702417	0.875519736314218	0.695201375055612	0.414969240244566	0.688966177022438	0.711145951660666	0.701436573088786	0.587194768528687	0.307628948308099	0.737891717215594	0.733897629255502	p.Asp92Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-0.748	-5.728	4.98	0.153	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D92X	92	D	X	nonsense	low	-0.0367917590001421	0.128628572320268	8	0.0454770678710028	-0.125925174149791	0.0523416561495071	0.177573136506034	-0.0666160969725328	-0.0303152649246649	-0.0572625821925348	-0.291474320435398	0.0165856604172397	-0.0342372153701963	-0.00858738902908431	0.278349103516093	0.391597843904157	0.277514623832221	0.279183583199965	0.270584687075975	0.271252520705831	0.299516357267291	0.269147334280088	0.289856543402366	p.Asp92Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D92Y	92	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp92Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.6	84.1	23.6	0.191	109.6	-0.7	-49.7	119.7	31.5508021390374	-0.5	0	0	29.16	0	0	1	33	4	5.21322528383342	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-0.748	-4.556	3.808	0.455	NA	22.33	0.000841002	0	0.02403724	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	1	0	0	2	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H93A	93	H	A	missense	possibly_wt-like	0.871823996807345	0.442693246222828	6	0.180728760970368	0.517602134334877	1.22604585927981	1.10322714076652	0.931584686327515	1.09699967615054	1.07760258857682	-0.0226165335708746	NA	NA	1.04414642259355	0.793435805785184	0.832002283719647	0.73766838565459	0.832077971877093	0.76828155677852	0.371681074350069	NA	NA	0.818590054791849	p.His93Ala	0	0	no	NA	NA	NA	NA	NA	NA	-0.239	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1	-3.541	2.541	2.663	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.76	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93C	93	H	C	missense	wt-like	0.955873893602088	0.0959213005398675	5	0.0428973096994662	0.871796711557474	1.0399510756467	0.832503192643975	0.900928386650856	0.946047408979822	1.06955198390484	NA	1.03033849583095	NA	NA	0.758043060748197	0.703198186109979	0.723536347435653	0.758043060748197	0.764750951691977	NA	0.799167444236064	NA	NA	p.His93Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1	-5.28	4.28	0.447	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H93D	93	H	D	missense	possibly_wt-like	0.838428840139545	0.434028010988592	4	0.217014005494296	0.413089205229947	1.26376847504914	NA	1.04501527613551	1.06185731888762	1.05936076436993	0.187482001165114	NA	NA	NA	0.775119777613722	NA	0.789957978569274	0.814842316225248	0.760281576658171	0.450160824601607	NA	NA	NA	p.His93Asp	1	0	NA	NA	NA	NA	NA	NA	NA	1.503	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1	-3.774	2.774	2.047	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	1	0	0	1	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H93E	93	H	E	missense	wt-like	1.21846097755631	0.322981549743335	4	0.161490774871668	0.901944874972378	1.53497708014025	NA	1.24808679113227	0.924622905994674	1.04167498568835	1.65945922740996	NA	NA	NA	0.818047990269333	NA	0.883570529378742	0.747535360504832	0.752525451159924	1	NA	NA	NA	p.His93Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1	-3.578	2.578	3.056	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93F	93	H	F	missense	wt-like	1.04212751744364	0.20798377001916	3	0.120079485607635	0.806776050370584	1.2774789845167	NA	1.07135170189711	1.2339535730328	0.821077277401021	NA	NA	NA	NA	0.802098627614943	NA	0.802098627614943	0.899247347829343	0.655781986203883	NA	NA	NA	NA	p.His93Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1	-3.228	2.228	9.086	9.086	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.76	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
H93G	93	H	G	missense	wt-like	1.05827257915228	0.0489377996581315	8	0.0173021249973067	1.02436103730155	1.09218412100301	1.06465680470388	0.99474984018439	1.03312034340828	1.14595164732193	1.06348134818165	1.05077333101131	1.01046331612069	1.10298400228613	0.804993706131061	0.81365142349652	0.766786458540927	0.800748195841348	0.798256141831209	0.777379717683167	0.809239216420775	0.831816138087853	0.848141114869004	p.His93Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1	-3.624	2.624	1.954	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93I	93	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1	-4.053	3.053	2.799	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
H93K	93	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1	-3.705	2.705	7.073	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93L	93	H	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1	-2.826	1.826	9.132	9.132	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	3	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.955	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
H93M	93	H	M	missense	possibly_wt-like	0.828970168852373	0.15423342955164	4	0.0771167147758198	0.677824185285719	0.980116152419028	1.00004727562743	0.722971837026574	0.676549160419908	0.916312402335577	NA	NA	NA	NA	0.669524435005019	0.78291172666737	0.641501372989107	0.625866981147075	0.697547497020931	NA	NA	NA	NA	p.His93Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1	-3.552	2.552	3.617	3.617	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H93N	93	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1	-2.494	1.494	7.781	7.781	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H93P	93	H	P	missense	possibly_wt-like	0.889899641838666	0.401740350973279	7	0.151843580042157	0.592291693672413	1.18750759000492	1.2223488136481	0.97779017649079	1.03944951094444	1.18321354103771	0.0571507345649456	NA	0.720089095797339	1.02925562038734	0.803852351643988	0.888677578563974	0.758968339001838	0.803852351643988	0.814597402748536	0.401477166404748	NA	0.675422501556639	0.81111117831712	p.His93Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1	-4.193	3.193	1.087	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H93Q	93	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1	-3.992	2.992	2.82	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	high	3.76	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H93R	93	H	R	missense	possibly_wt-like	0.816582533433714	0.164396357370095	8	0.0581228895493807	0.702663763239529	0.9305013036279	0.928002085455938	0.90004437225286	0.941710458970482	0.922271578582359	0.766410247946756	0.595627671341053	0.539683137248945	0.938910715671322	0.711644867312014	0.748634316886999	0.72312883167575	0.755915992937093	0.700160902948279	0.666412424252583	0.584910350804775	0.578257044244814	0.765735625466755	p.His93Arg	1	0	no	NA	NA	NA	NA	NA	38.7	-0.142	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1	-3.137	2.137	20.147	20.147	58.56	0.000878491	0	0.025108734	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Apr 1, 2005)	no assertion criteria provided	1	0	0	0	0	5	0	2	0	0	1	2	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.41	Deleterious	DAMAGING	effect	DAMAGING	null	D	A	D	D	D	D	0.857142857142857
H93S	93	H	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1	-3.634	2.634	2.571	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.555	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93T	93	H	T	missense	wt-like	0.908694282017087	0.168974244663003	7	0.0638662613361842	0.783518709970943	1.03386985406323	1.27112046146563	0.864190895664838	0.823800311824991	0.904309475183119	0.88250455702899	NA	0.876657095358869	0.738277177593165	0.706600982366871	0.911881983381646	0.706600982366871	0.69808667093533	0.692283594819231	0.709778040266268	NA	0.759748991658198	0.664967820804863	p.His93Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1	-3.83	2.83	2.02	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
H93V	93	H	V	missense	low	0.507832536554919	0.223671273721633	7	0.0845397950994996	0.342137582899504	0.673527490210334	NA	0.402926339149128	0.492116282880244	0.106016297350173	0.814029690792394	0.484042319467103	0.674400202606634	0.581296623638758	0.535411422222256	NA	0.493965784692186	0.535411422222256	0.34219089134591	0.684200087485643	0.529912978263904	0.650814765555751	0.586124642599875	p.His93Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1	-3.84	2.84	2.33	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.76	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
H93W	93	H	W	missense	possibly_wt-like	0.784530600041188	0.435712293871792	6	0.177878799107248	0.435894560177748	1.13316663990463	0.889149399692482	1.05377145932176	0.814114907695235	0.873786612154484	-0.068272924274467	NA	NA	1.14463414565764	0.71174278096865	0.730149121306117	0.793994431655434	0.693336440631184	0.678897746195986	0.354626685349655	NA	NA	0.869059818449684	p.His93Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1	-5.281	4.281	0.737	NA	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H93X	93	H	X	nonsense	low	-0.0611522317447167	0.0893861710033832	6	0.0364917515032417	-0.132674750423856	0.0103702869344224	NA	0.0686643368031285	-0.040643893337543	-0.0861472727310541	-0.208508578316521	NA	-0.0570410399322464	-0.0432369429540643	0.273285877115574	NA	0.339876627092762	0.274117881962328	0.257917261523033	0.302243363783842	NA	0.256865345038387	0.272453872268819	p.His93Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H93Y	93	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His93Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.7	82.8	25.7	0.626	112.4	108	70.8	11.7	51.3888888888889	-0.7	0	0	23.97	0	0	0	0	3	5.00335865794169	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1	-2.832	1.832	8.506	8.506	58.56	0.000878491	0	0.025108734	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	0	1	1	0	2	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.41	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94A	94	N	A	missense	wt-like	1.08329019906648	0.2875732402339	7	0.108692468196562	0.870256876010453	1.29632352212251	NA	1.29158554071823	1.17364397548779	1.28212139121541	1.20854715417648	0.459809113044529	1.0651233973766	1.10220082144633	0.857973592881393	NA	0.9036227208731	0.869668357210971	0.857973592881393	0.831567283716497	0.517969092627484	0.861255696707019	0.847747763813961	p.Asn94Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.482	-2.987	1.505	10.638	10.638	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94C	94	N	C	missense	possibly_wt-like	0.840436110176136	0.462380806380027	5	0.206782982911382	0.435148911054066	1.24572330929821	NA	1.255293683158	0.949525365909339	0.747527221571122	0.0912281602982298	1.15860611994399	NA	NA	0.759748833288173	NA	0.886892785313789	0.759748833288173	0.623526495863852	0.414206373984058	0.862387053170452	NA	NA	p.Asn94Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.482	-3.398	1.916	17.989	17.989	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N94D	94	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn94Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.482	-3.701	2.219	3.683	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94E	94	N	E	missense	possibly_low	0.698870063066014	0.517674588797707	6	0.211339765893247	0.284651733414123	1.1130883927179	NA	0.950781861704723	1.0111998087648	0.980117924517799	-0.271334458769233	0.486681294172412	NA	1.03577394800559	0.736023733767461	NA	0.746517960423487	0.789997215649758	0.725529507111434	0.278775520881188	0.531213656825708	NA	0.814384995698048	p.Asn94Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.482	-3.042	1.56	12.089	12.089	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N94F	94	N	F	missense	possibly_low	0.68766456655041	0.272694111391512	2	0.192823855354578	0.309736754695276	1.06559237840554	0.880488421904988	NA	NA	NA	0.494840711195832	NA	NA	NA	0.645499680445596	0.726028431444462	NA	NA	NA	0.564970929446729	NA	NA	NA	p.Asn94Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.482	-4.499	3.017	1.688	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.555	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94G	94	N	G	missense	wt-like	0.921231678385573	0.2455829258575	8	0.0868266761087357	0.751054520315127	1.09140883645602	0.377274161596211	1.12887587008776	1.09237855491512	1.11657300875315	0.897654734597093	0.865745740948219	1.01947220720926	0.87187914897777	0.758720622973936	0.486610902434252	0.828616301044452	0.829811531588436	0.785372094608316	0.715437204683122	0.718044170385213	0.836668267305407	0.732069151339557	p.Asn94Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.482	-3.591	2.109	2.878	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94H	94	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn94His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.482	-1.933	0.451	19.327	19.327	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	low	0.945	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
N94I	94	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn94Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.482	-4.238	2.756	3.027	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94K	94	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn94Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.482	-3.259	1.777	16.226	16.226	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94L	94	N	L	missense	possibly_wt-like	0.870035309304335	0.34495694568867	8	0.121960697756929	0.630996734171379	1.10907388443729	0.826120629008599	1.2007307324558	1.1913847349974	1.10666142069059	0.36239097511873	0.435724115573248	0.68265940628528	1.15461046030503	0.740593432294909	0.70016151220214	0.861740183310474	0.878369356396149	0.781025352387679	0.515495942763576	0.506098255135568	0.655263118087587	0.874070403097015	p.Asn94Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.482	-3.124	1.642	9.877	9.877	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.725	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94M	94	N	M	missense	wt-like	1.0481056493542	0.28238742782948	4	0.14119371391474	0.771371055237857	1.32484024347054	NA	1.26108967911715	1.15071951913096	1.14870093122167	0.631912467947022	NA	NA	NA	0.828943422832865	NA	0.889564641906901	0.858425001143078	0.799461844522652	0.616172415691699	NA	NA	NA	p.Asn94Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.482	-3.596	2.114	3.979	3.979	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N94N	94	N	N	synonymous	wt-like	1.06786692206168	0.0661703293524842	5	0.0295922709051409	1.00986713686685	1.12586670725651	0.986082639945856	1.14927039804284	1.0683532113006	1.11363237123595	NA	NA	NA	1.02199598978315	0.807465042951875	0.776267680915647	0.838017835200831	0.818028242654253	0.784082473493022	NA	NA	NA	0.807465042951875	p.Asn94=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	0	-3.5	-3.5	0	187	187	0	11.6	11.6	0	132	132	0	5.47	5.47	0	NA	NA	NA	NA	NA	NA	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
N94P	94	N	P	missense	low	0.309746659854409	0.185836814216832	8	0.0657032357634134	0.180970684090375	0.438522635618443	0.662196633305966	0.245707530788836	0.344710446807301	0.339790355258632	0.161623174815267	0.070027908302034	0.201854623419178	0.452062606138056	0.442607219758922	0.622170324169187	0.421490559961299	0.463115866957764	0.444712864735776	0.440501574782068	0.325856581741035	0.396304838766868	0.521217108416285	p.Asn94Pro	0	0	NA	NA	NA	NA	NA	NA	NA	32.0605	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.482	-4.241	2.759	1.588	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.33	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94Q	94	N	Q	missense	wt-like	0.906444868416454	0.163360610093361	7	0.0617445069044029	0.785427858640639	1.02746187819227	NA	0.859576735521721	1.03455937285854	0.977853307297203	0.891373701385016	0.605475026150814	0.861146808142743	1.11512912755914	0.724536355739099	NA	0.704473932195174	0.801453971378602	0.724536355739099	0.71309100118187	0.589763843059084	0.751395253441795	0.854240980438978	p.Asn94Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.482	-2.456	0.974	8.334	8.334	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N94R	94	N	R	missense	possibly_wt-like	0.873968519903544	0.244403688367458	8	0.0864097526958165	0.704608516706731	1.04332852310036	1.00540688290818	1.03365318262012	0.78189959755117	0.972005637232595	1.12693243374348	0.364093484876999	0.981350877658029	0.726406062637786	0.75334604784875	0.785461701961856	0.784720244677703	0.677536362446148	0.721971851019797	0.801081098344097	0.470793473499092	0.816136371081	0.659005576384508	p.Asn94Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.482	-3.94	2.458	6.277	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94S	94	N	S	missense	possibly_wt-like	0.999681887975861	0.506237279744578	4	0.253118639872289	0.503578470010411	1.49578530594131	NA	0.974978942072342	1.31544562571732	1.41368405783306	NA	NA	NA	0.294618926280717	0.83667150516929	NA	0.757672407246769	0.939215325729183	0.915670603091811	NA	NA	NA	0.442141326126419	p.Asn94Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.482	-2.752	1.27	4.911	4.911	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94T	94	N	T	missense	possibly_wt-like	0.913412243643988	0.321471988888691	5	0.143766644003434	0.631634799219066	1.19518968806891	NA	1.16369725078841	1.10021535906558	1.15785917379694	0.463466756770087	NA	NA	0.681822677798915	0.803478205918782	NA	0.84466837151897	0.833655111480864	0.803478205918782	0.553251570666671	NA	NA	0.636613657976234	p.Asn94Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.482	-2.822	1.34	10.19	10.19	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N94V	94	N	V	missense	wt-like	1.01598432716606	0.197987569489049	6	0.0808280867769996	0.857564188143859	1.17440446618825	1.0837863112372	0.88884749761329	1.22623398959014	1.21379218901715	NA	0.966318380178498	NA	0.716927595360066	0.795183235571912	0.822752793522441	0.71796726090537	0.895461259121691	0.828007715947933	NA	0.767613677621383	NA	0.65424503461126	p.Asn94Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.482	-3.934	2.452	2.964	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.53	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N94W	94	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn94Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.482	-5.677	4.195	0.316	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N94X	94	N	X	nonsense	low	-0.0674333384139273	0.0552530611643105	8	0.0195349071152995	-0.10572105280125	-0.029145624026605	-0.0855258668259863	-0.0554474098850192	0.00485007965534308	-0.0826567639997436	-0.182775834603208	-0.0603504520103472	-0.0537234243219677	-0.023837035320489	0.274309477083258	0.266421515983422	0.282663200615487	0.296430513038081	0.259448029506744	0.311855516969228	0.261596648578232	0.258652190886226	0.282197438183095	p.Asn94Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N94Y	94	N	Y	missense	possibly_wt-like	0.906774185691233	0.192025539927044	2	0.135782561443421	0.64064525553353	1.17290311584894	NA	0.770991624247812	NA	NA	NA	NA	NA	1.04255674713465	0.740714665063834	NA	0.663637686746256	NA	NA	NA	NA	NA	0.817791643381411	p.Asn94Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	81	28.3	0.766	73.3	-109.6	-114	165.1	14.9732620320856	-3.1	0	0	22.36	1	2	0	0	5	7.99588380730986	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.482	-4.272	2.79	3.168	NA	58.56	0.002832038	0	0.080944371	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.555	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P95A	95	P	A	missense	low	0.618920578065124	0.091085006143734	8	0.0322034127543263	0.555803048887366	0.682038107242881	0.659265930755223	0.62441642009508	0.639747477981735	0.774917102520093	0.462594144726895	0.547387658877193	0.589266461650372	0.653769427914397	0.606389900271032	0.620775964711782	0.59606898442789	0.60781750537721	0.635538370367487	0.552925617059702	0.561134166096874	0.604962295164854	0.622523967730164	p.Pro95Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.593	-1.792	0.199	12.722	12.722	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	0.91	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P95C	95	P	C	missense	possibly_low	0.635511407539907	0.200311589222205	7	0.0757106642580114	0.4871212323486	0.783901582731213	0.665737255849005	0.477102332148374	0.824618371888378	0.955182236947656	0.507286605957716	0.38994556432276	0.628707485665457	NA	0.62385486923731	0.62385486923731	0.528159669115589	0.698487890507756	0.714593922896503	0.569619941938877	0.483535257437191	0.626204970108123	NA	p.Pro95Cys	0	0	NA	NA	NA	NA	NA	NA	NA	5.348	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.593	-2.787	1.194	15.47	15.47	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P95D	95	P	D	missense	low	0.292378199777147	0.15394455676077	6	0.0628476021238016	0.169199163099793	0.415557236454501	NA	0.282390934641335	0.280258520290268	0.399270919431524	NA	0.000378880608763982	0.402678936994741	0.38929100669625	0.454599574798713	NA	0.438400991771792	0.431505260895264	0.470798157825634	NA	0.291528478107117	0.50446748718997	0.489690194564014	p.Pro95Asp	0	0	NA	NA	NA	NA	NA	NA	NA	11.474	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.593	-4.024	2.431	3.537	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95E	95	P	E	missense	low	0.371283689983995	0.237974043937683	2	0.168273060214721	0.0414745523948022	0.701092827573188	NA	0.203010629769274	0.539556750198716	NA	NA	NA	NA	NA	0.480243361697104	NA	0.401808007161295	0.558678716232914	NA	NA	NA	NA	NA	p.Pro95Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.593	-3.93	2.337	3.727	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95F	95	P	F	missense	low	0.422166653178163	0.109108190296325	8	0.0385755706207618	0.346559924078388	0.497773382277937	0.488664374483583	0.484113726159751	0.261354468600835	0.348598619393866	0.546856499377587	0.316509934737894	0.384030195703354	0.547205406968431	0.512907601050457	0.539607750156834	0.531391803756165	0.422233722196078	0.448575742547638	0.584400793966112	0.447340841143065	0.494423398344748	0.569002395267609	p.Pro95Phe	0	0	NA	NA	NA	NA	NA	NA	NA	20.478	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.593	-4.525	2.932	1.506	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95G	95	P	G	missense	low	0.507344954423279	0.215611132619562	8	0.0762300469873022	0.35793680778837	0.656753101058187	0.762123357546235	0.728507174217071	0.65442210422342	0.536765475807932	0.222838595071851	0.37042135872142	0.214752190678198	0.568929379120103	0.55550491275119	0.669713113169264	0.644053070276642	0.615014711951287	0.53109660743202	0.463367849881591	0.473912309702668	0.403251383276906	0.579913218070361	p.Pro95Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.593	-3.662	2.069	4.838	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P95H	95	P	H	missense	low	0.310153164780896	0.14599491663012	5	0.0652909115908727	0.182185329544997	0.438121000016795	0.545446176971252	0.204831466856943	0.184433228749331	0.346680170678953	NA	NA	NA	0.269374780648	0.42946250303263	0.56662319847899	0.402647382414825	0.384507510705063	0.447734403906987	NA	NA	NA	0.42946250303263	p.Pro95His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.593	-5.112	3.519	1.394	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95I	95	P	I	missense	low	0.514898171290292	0.180381133605259	8	0.0637743613851976	0.389902719838263	0.639893622742321	0.133560282104279	0.638097926639624	0.429257074899219	0.512791435095759	0.569653831465525	0.487064723007069	0.62346811069699	0.725291986413873	0.562159549148323	0.370657561251816	0.602375928691203	0.504581968887548	0.520582754928747	0.592916459869784	0.531402638426863	0.623383077367243	0.658446033765736	p.Pro95Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.593	-3.296	1.703	5.66	5.66	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.145	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95K	95	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro95Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.593	-3.934	2.341	3.913	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95L	95	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro95Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.593	-3.53	1.937	4	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	4	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P95M	95	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro95Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.593	-4.817	3.224	1.08	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95N	95	P	N	missense	low	0.420446064715419	0.171371543789902	8	0.0605889903581237	0.301693825753852	0.539198303676986	0.367218238730709	0.355049910852872	0.585429392995103	0.555862255826238	0.159300901061508	0.354425746430818	0.306344430321319	0.679937641504786	0.476861043723084	0.481826530459383	0.471895556986786	0.581177066846206	0.53947152974113	0.439634117688949	0.466028509245066	0.452582358388523	0.635666902160198	p.Pro95Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.593	-3.321	1.728	7.859	7.859	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.89	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95P	95	P	P	synonymous	possibly_wt-like	0.726520781524853	0.106254938271899	3	0.0613463172140077	0.606284209201228	0.846757353848478	0.787486512969001	NA	0.788246899092234	0.603828932513324	NA	NA	NA	NA	0.680649412116144	0.681780306963602	NA	0.680649412116144	0.560507389728809	NA	NA	NA	NA	p.Pro95=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P95Q	95	P	Q	missense	low	0.497207876839915	0.0985638284010014	4	0.0492819142005007	0.400617099917741	0.59379865376209	NA	0.393115938477746	0.529427464325265	0.618842459343993	NA	NA	NA	0.447445645212656	0.536304515898502	NA	0.489443355087396	0.553710783034587	0.567091595059345	NA	NA	NA	0.518898248762417	p.Pro95Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.593	-4.377	2.784	2.389	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P95R	95	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro95Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.593	-4.326	2.733	2.859	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P95S	95	P	S	missense	low	0.534020952102018	0.104674448128753	5	0.0468118363046335	0.442271438894752	0.625770465309284	NA	0.502404910000228	0.388140920634044	0.547223442686299	NA	0.55341463131248	0.678920855877039	NA	0.539823731674068	NA	0.539823731674068	0.484416449786456	0.535682964924415	NA	0.56410469621351	0.65324955953873	NA	p.Pro95Ser	1	0	NA	NA	NA	NA	NA	NA	NA	5.893	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.593	-2.466	0.873	15.88	15.88	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	1	0	0	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.245	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P95T	95	P	T	missense	low	0.22797550022726	0.077977756642101	2	0.0551386005033439	0.119905829082763	0.336045171371756	NA	NA	0.283114100730604	NA	NA	0.172836899723916	NA	NA	0.404717056625626	NA	NA	0.432905787353622	NA	NA	0.37652832589763	NA	NA	p.Pro95Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.593	-3.674	2.081	5.931	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jul 24, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.145	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P95V	95	P	V	missense	possibly_low	0.683032370336221	0.209945194819174	2	0.148453670934169	0.392068521932489	0.973996218739953	NA	NA	NA	NA	0.83148604127039	NA	0.534578699402052	NA	0.633114261233723	NA	NA	NA	NA	0.690720694721376	NA	0.575507827746069	NA	p.Pro95Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.593	-1.757	0.164	8.284	8.284	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.86	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
P95W	95	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro95Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.593	-5.786	4.193	0.363	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P95X	95	P	X	nonsense	low	0.0773020779883025	0.331826287555976	7	0.125418547906703	-0.168513758902146	0.323117914878751	0.693972066579335	0.338310542478212	-0.0375336206905581	-0.0289561696035423	-0.312814608657247	NA	-0.0619810325176614	-0.0498826316704204	0.275643322840575	0.637288329197246	0.464178989882255	0.275643322840575	0.282998507942907	0.263281115802646	NA	0.254204697670966	0.269116088023831	p.Pro95Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P95Y	95	P	Y	missense	low	0.405463632421508	0.245877801930825	8	0.0869309305442647	0.235082139412196	0.57584512543082	0.272003099216409	0.585153483500985	0.5574897117194	0.446196771427403	0.00573711534791979	0.80536311630481	0.28272198276417	0.289043779090966	0.465618513375626	0.43652540283854	0.577969431435919	0.567473981367688	0.491377562540857	0.382272234772311	0.688283223748951	0.439859464210395	0.43934121928307	p.Pro95Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	81.9	31.9	0.443	41.3	-108.1	-83.9	165	5.19480519480519	-0.4	0	0	21.73	0	0	0	0	5	9.72843141827088	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.593	-4.573	2.98	1.3	NA	72.21	0.002776523	0	0.079357652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96A	96	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-0.84	-2.32	1.48	16.963	16.963	72.21	0.000815071	0	0.023296084	0	NA	NA	not provided	Pathogenic(Last reviewed: May 26, 2016)	criteria provided, single submitter	1	0	0	0	0	1	0	2	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	neutral	DAMAGING	null	N	D	D	D	D	D	0.785714285714286
P96C	96	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-0.84	-2.929	2.089	10.553	10.553	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P96D	96	P	D	missense	low	0.130888594121027	0.031793970356452	2	0.0224817320398913	0.0868252090127601	0.174951979229294	NA	NA	NA	NA	0.153370326160918	NA	NA	0.108406862081136	0.393017751161332	NA	NA	NA	NA	0.437418823624042	NA	NA	0.348616678698622	p.Pro96Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-0.84	-3.786	2.946	3.537	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96E	96	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-0.84	-3.74	2.9	3.727	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96F	96	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-0.84	-4.584	3.744	1.506	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96G	96	P	G	missense	possibly_low	0.61318072150823	0.281017919917044	7	0.106214790007595	0.40500355846786	0.821357884548601	0.439602102654575	0.590226674126223	0.391161079344282	0.544854155382957	1.08470405105972	0.909611515481748	NA	0.332105472508107	0.534643910325973	0.516265073258686	0.580308086934593	0.485897694062534	0.534643910325973	0.785307200012477	0.739664412677764	NA	0.460968871131478	p.Pro96Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-0.84	-3.556	2.716	4.838	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P96H	96	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-0.84	-4.946	4.106	1.394	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96I	96	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-0.84	-4.066	3.226	2.516	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96K	96	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-0.84	-3.738	2.898	3.913	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96L	96	P	L	missense	possibly_low	0.48163979406367	0.21792055413965	3	0.12581649059448	0.235044003837268	0.728235584290072	0.598288436401345	NA	NA	NA	NA	0.230224332245876	NA	0.616406613543789	0.591764304719314	0.591764304719314	NA	NA	NA	NA	0.404813024135976	NA	0.603758566809759	p.Pro96Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-0.84	-3.017	2.177	7.827	7.827	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	1	0	0	0	1	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P96M	96	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-0.84	-4.837	3.997	1.08	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96N	96	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-0.84	-4.133	3.293	3.97	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96Q	96	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-0.84	-4.18	3.34	2.389	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P96R	96	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-0.84	-4.163	3.323	2.859	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P96S	96	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-0.84	-2.973	2.133	15.88	15.88	72.21	0.000815071	0	0.023296084	0	NA	NA	not provided	Conflicting interpretations of pathogenicity(Last reviewed: Jul 26, 2016)	criteria provided, conflicting interpretations	0	0	1	0	0	4	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P96T	96	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-0.84	-3.621	2.781	5.931	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.58	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P96V	96	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-0.84	-3.66	2.82	3.999	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96W	96	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-0.84	-5.69	4.85	0.363	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P96X	96	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P96Y	96	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro96Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.2	83.1	32.5	0.451	46	-78.4	-86.3	172.2	1.94805194805195	-0.2	0	0	21.36	0	0	0	0	4	11.3224943303143	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-0.84	-4.556	3.716	1.3	NA	72.21	0.000815071	0	0.023296084	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q97A	97	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.613	-2.609	-0.004	9.272	9.272	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.525	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q97C	97	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.613	-3.897	1.284	18.828	18.828	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q97D	97	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.613	-3.213	0.6	14.373	14.373	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.155	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q97E	97	Q	E	missense	possibly_wt-like	0.91612317066471	0.302159318873998	4	0.151079659436999	0.620012479371615	1.21223386195781	1.28937619199544	0.587807062899922	NA	NA	0.780116583070008	1.00719284469348	NA	NA	0.729645921898839	0.920567631302354	0.579192686880258	NA	NA	0.671532258899162	0.787759584898515	NA	NA	p.Gln97Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.613	-3.023	0.41	10.025	10.025	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	0.95	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
Q97F	97	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.613	-4.688	2.075	4.565	NA	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q97G	97	Q	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.613	-3.82	1.207	4.971	NA	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.5	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Q97H	97	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.613	-3.6	0.987	14.671	14.671	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Q97I	97	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.613	-4.234	1.621	9.595	NA	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q97K	97	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.613	-2.496	-0.117	15.194	15.194	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Q97L	97	Q	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.613	-2.909	0.296	31.309	31.309	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.155	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Q97M	97	Q	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.613	-3.62	1.007	6.551	6.551	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.15	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q97N	97	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.613	-3.279	0.666	12.889	12.889	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q97P	97	Q	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.613	-1.989	-0.624	21.729	21.729	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	-0.905	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
Q97R	97	Q	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.613	-2.825	0.212	17.672	17.672	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Q97S	97	Q	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.613	-2.481	-0.132	16.317	16.317	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.265	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q97T	97	Q	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.613	-2.164	-0.449	9.885	9.885	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.07	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q97V	97	Q	V	missense	possibly_wt-like	0.761529621270974	0.174703956291453	6	0.0713225914932593	0.621739910660123	0.901319331881825	0.707417223686794	0.489692556959922	0.655578058948576	NA	0.940191472334464	NA	0.905075380185349	0.871223035510741	0.687505752266479	0.643685219241353	0.533963550865782	0.615581652792587	NA	0.731326285291604	NA	0.775054892102955	0.731739619625593	p.Gln97Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.613	-3.331	0.718	8.017	8.017	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.295	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Q97W	97	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.613	-5.81	3.197	0.617	NA	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q97X	97	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.234e-05	1	30918	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q97Y	97	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln97Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.8	81	34.4	0.475	45.3	-120	-64.8	140.6	54.2056074766355	-2.8	0	0	19.79	0	0	0	0	5	15.0941544267971	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.613	-4.651	2.038	2.405	NA	83.37	0.003328586	0	0.095136518	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L98A	98	L	A	missense	low	0.175951772658162	0.188425652998984	4	0.0942128264994921	-0.00870197416256277	0.360605519478888	NA	0.168852594819145	NA	NA	0.380995855059152	-0.072733927950423	NA	0.226692568704776	0.39704358646555	NA	0.386061727913949	NA	NA	0.522445569199662	0.2554931714803	NA	0.408025445017151	p.Leu98Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.311	-3.494	2.183	5.156	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L98C	98	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.311	-5.074	3.763	1.384	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98D	98	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.311	-4.37	3.059	1.516	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98E	98	L	E	missense	low	0.166482549478484	0.126954790632454	8	0.0448852966801632	0.0785089845499685	0.254456114406999	0.290691044655878	0.115607864310774	0.235240831834709	0.368946765177415	0.137151109230774	-0.038693572327183	0.11755122824655	0.105365124698952	0.385471513989269	0.445416688464368	0.361516803234922	0.409426224743615	0.457499453241709	0.431360332566249	0.272270733124322	0.350899587128849	0.347088972008621	p.Leu98Glu	0	0	NA	NA	NA	NA	NA	NA	NA	3.719	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.311	-4.22	2.909	1.728	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98F	98	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.311	-1.952	0.641	19.225	19.225	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.58	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
L98G	98	L	G	missense	low	0.138374053908411	0.0737306545262182	8	0.0260677228984058	0.0872822558685657	0.189465851948256	0.140050357560345	0.254531398441996	0.149411539829523	0.166134259838272	0.133823448506267	-0.0119970371484368	0.11480318459194	0.160235279647383	0.371150551604352	0.373745386759439	0.425558214447605	0.36733103713922	0.368555716449264	0.430117325408159	0.28542872623111	0.349419508973107	0.374647400716872	p.Leu98Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.311	-4.09	2.779	1.854	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L98H	98	L	H	missense	possibly_low	0.653365063915037	0.578498130636759	2	0.409059951076993	-0.148377707713586	1.45510783554366	NA	NA	NA	NA	1.06242501499203	NA	NA	0.244305112838043	0.596928224182289	NA	NA	NA	NA	0.776985137278272	NA	NA	0.416871311086306	p.Leu98His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.311	-5.107	3.796	1.462	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98I	98	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.311	-1.89	0.579	22.639	22.639	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.795	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
L98K	98	L	K	missense	low	0.0163249839117523	0.14171003344331	2	0.100204125609937	-0.180071493386051	0.212721461209556	NA	NA	NA	NA	NA	-0.0838791416981843	NA	0.116529109521689	0.301348030846917	NA	NA	NA	NA	NA	0.25	NA	0.352696061693834	p.Leu98Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.311	-4.123	2.812	1.97	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98L	98	L	L	synonymous	wt-like	1.06633330502248	0.294961804106914	5	0.131910928949807	0.807792635113631	1.32487397493132	NA	1.01857575609681	1.05286438951154	0.621657198984049	NA	1.41888911745498	NA	1.21968006306499	0.810431711869146	NA	0.777769804796894	0.810431711869146	0.568326003466586	NA	0.990673434310668	NA	0.906751484650732	p.Leu98=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L98M	98	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.311	-2.67	1.359	6.712	6.712	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.385	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L98N	98	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.311	-4.455	3.144	1.265	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98P	98	L	P	missense	possibly_low	0.508049774490783	0.31675154673493	2	0.223977166647597	0.0690625945021673	0.947036954479398	0.284072607843186	NA	0.73202694113838	NA	NA	NA	NA	NA	0.547671993471326	0.442267791637333	NA	0.653076195305318	NA	NA	NA	NA	NA	p.Leu98Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.311	-4.481	3.17	1.267	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L98Q	98	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.311	-4.526	3.215	1.227	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L98R	98	L	R	missense	low	0.210472803643321	0.127535866039015	7	0.0482040263972117	0.115994647994968	0.304950959291674	0.16723931902953	0.166211865093942	0.11432571233093	0.170306792362984	0.492424146400412	0.210724391221301	NA	0.152077399064147	0.384844395952947	0.386681256198655	0.384844395952947	0.350123106649482	0.370385587018711	0.564068251082744	0.395202035748674	NA	0.370550121044985	p.Leu98Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.311	-4.386	3.075	1.609	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Apr 15, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L98S	98	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.311	-3.95	2.639	2.659	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L98T	98	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.311	-3.282	1.971	7.078	7.078	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L98V	98	L	V	missense	possibly_low	0.684467496230203	0.322761928712505	8	0.114113574250731	0.460809000551634	0.908125991908773	0.909707185068448	0.897496564519993	0.910609715441047	0.944518589900447	0.100990869981532	0.316434831460878	0.559993152777784	0.835989060691498	0.711980394141259	0.739930032867756	0.721954335189378	0.740662556692639	0.709917364049066	0.417853115350849	0.447303824788896	0.589195884418103	0.714043424233452	p.Leu98Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.311	-2.644	1.333	19.975	19.975	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.935	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
L98W	98	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu98Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.311	-5.294	3.983	0.893	NA	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L98X	98	L	X	nonsense	low	-0.0293599273406699	0.0346410456403969	5	0.01549194657272	-0.0597235846736199	0.00100372999228004	-0.0174559465302566	-0.0900028948873867	-0.00315567826964652	-0.0136112623765694	NA	NA	NA	-0.0225738546394905	0.289728040656967	0.298807585700774	0.266733703582968	0.292504069350914	0.289728040656967	NA	NA	NA	0.282831868225723	p.Leu98Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L98Y	98	L	Y	missense	possibly_low	0.369783824765501	0.46165957723751	6	0.188471733183483	0.000386015622031444	0.739181633908971	NA	0.670683372646969	0.331563087265125	0.770031826109823	-0.305310040581464	NA	-0.0469932964977033	0.798727999650256	0.537032491499503	NA	0.617397270901904	0.456667712097103	0.633395924868543	0.266084355858904	NA	0.262276993265668	0.695329128725011	p.Leu98Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	81.2	38.1	0.905	111	55.7	-50	-48.8	2.61780104712042	-2.3	1	0	19.02	0	0	0	0	5	17.1384648629917	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.311	-3.399	2.088	9.845	9.845	83.37	0.003465389	0	0.099046593	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E99A	99	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.958	-2.749	0.791	12.722	12.722	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.595	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
E99C	99	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.958	-4.292	2.334	13.432	13.432	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E99D	99	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.958	-2.541	0.583	33.077	33.077	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.135	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
E99F	99	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.958	-4.704	2.746	2.024	NA	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E99G	99	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.958	-2.912	0.954	20.749	20.749	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.085	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
E99H	99	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.958	-3.05	1.092	10.805	10.805	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E99I	99	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.958	-3.314	1.356	7.883	7.883	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.23	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E99K	99	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.958	-2.835	0.877	9.282	9.282	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.05	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
E99L	99	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.958	-3.374	1.416	13.884	13.884	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.885	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E99M	99	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.958	-5.085	3.127	1.843	NA	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E99N	99	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.958	-2.606	0.648	12.575	12.575	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.68	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E99P	99	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.958	-3.401	1.443	15.345	15.345	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.51	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E99Q	99	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.958	-2.587	0.629	15.872	15.872	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.33	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E99R	99	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.958	-2.761	0.803	10.415	10.415	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.885	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E99S	99	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.958	-2.478	0.52	7.967	7.967	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.99	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
E99T	99	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.958	-3.237	1.279	7.322	7.322	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
E99V	99	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.958	-3.17	1.212	9.286	9.286	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.51	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
E99W	99	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.958	-4.365	2.407	14.169	14.169	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E99X	99	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E99Y	99	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu99Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	82.7	39	0.536	93.6	71.1	-67.5	-3.5	57.0093457943925	-0.8	1	0	22.73	0	0	0	0	5	19.3105794283859	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.958	-4.617	2.659	1.944	NA	83.37	0.003437753	0	0.098256707	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L100A	100	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.796	-3.577	1.781	4.256	NA	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L100C	100	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.796	-5.349	3.553	0.843	NA	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L100D	100	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.796	-2.467	0.671	12.699	12.699	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.49	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L100E	100	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.796	-2.371	0.575	9.067	9.067	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L100F	100	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.796	-3.55	1.754	22.573	22.573	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.895	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
L100G	100	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.796	-3.967	2.171	2.626	NA	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L100H	100	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.796	-4.046	2.25	7.379	7.379	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L100I	100	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.796	-2.707	0.911	8.422	8.422	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.825	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
L100K	100	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.796	-3.026	1.23	10.175	10.175	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.27	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L100M	100	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.796	-2.65	0.854	5.707	5.707	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.96	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
L100N	100	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.796	-3.624	1.828	12.339	12.339	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L100P	100	L	P	missense	low	0.100788344822993	0.0602206531556075	3	0.0347684103101651	0.0326435128153584	0.168933176830628	NA	0.107843431091649	0.0373508994621185	0.157170703915211	NA	NA	NA	NA	0.357937530192893	NA	0.357937530192893	0.312370620140214	0.364624735184514	NA	NA	NA	NA	p.Leu100Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.796	-3.704	1.908	36.706	36.706	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L100Q	100	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.796	-2.679	0.883	8.706	8.706	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.465	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
L100R	100	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.796	-3.16	1.364	9.049	9.049	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L100S	100	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.796	-3.139	1.343	8.568	8.568	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.55	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L100T	100	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.796	-3.025	1.229	7.139	7.139	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.49	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L100V	100	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.796	-2.622	0.826	12.159	12.159	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L100W	100	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.796	-5.691	3.895	1.049	NA	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L100X	100	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L100Y	100	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu100Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.8	85.5	36.6	0.848	90	63.7	-76.8	-33.5	21.9895287958115	-3.8	1	0	23.63	0	0	0	0	5	16.6347959969457	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.796	-4.502	2.706	5.235	NA	74.19	0.003029132	0	0.086577636	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
I101A	101	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.613	-2.935	1.322	8.194	8.194	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101C	101	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.613	-5.063	3.45	1.068	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I101D	101	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.613	-4.354	2.741	2.869	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101E	101	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.613	-4.185	2.572	3.023	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101F	101	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.613	-3.271	1.658	9.947	9.947	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I101G	101	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.613	-4.059	2.446	3.924	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101H	101	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.613	-5.234	3.621	1.131	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101K	101	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.613	-4.09	2.477	3.174	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101L	101	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.613	-1.579	-0.034	15.934	15.934	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.075	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I101M	101	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.613	-1.966	0.353	8.239	8.239	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.675	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
I101N	101	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.613	-4.436	2.823	3.22	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I101P	101	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.613	-4.414	2.801	1.705	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101Q	101	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.613	-4.466	2.853	1.937	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101R	101	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.613	-4.372	2.759	2.319	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101S	101	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.613	-3.385	1.772	12.879	12.879	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I101T	101	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.613	-3.303	1.69	5.248	5.248	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	10	3	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.285	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I101V	101	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.613	-2.19	0.577	9.353	9.353	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.675	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I101W	101	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.613	-5.527	3.914	0.462	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I101X	101	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I101Y	101	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile101Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.2	87.1	38.8	0.927	95.7	48	-60.3	-61.2	0	-4.4	1	0	20.33	0	0	0	0	7	16.5563956784078	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.613	-4.331	2.718	2.307	NA	58.56	0.002845232	0	0.081321469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.285	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K102A	102	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.533	-2.757	0.224	8.985	8.985	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.26	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K102C	102	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.533	-3.27	0.737	12.232	12.232	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.91	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K102D	102	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.533	-3.41	0.877	14.373	14.373	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K102E	102	K	E	missense	possibly_wt-like	0.889900833093857	0.306543394485179	2	0.216758912968413	0.465061170347716	1.31474049584	NA	NA	NA	NA	1.10665974606227	NA	NA	0.673141920125444	0.712881123464686	NA	NA	NA	NA	0.793508482627628	NA	NA	0.632253764301744	p.Lys102Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.533	-2.965	0.432	11.647	11.647	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.015	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
K102F	102	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.533	-2.78	0.247	11.382	11.382	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.32	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K102G	102	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.533	-3.442	0.909	19.23	19.23	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K102H	102	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.533	-4.225	1.692	9.4	9.4	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K102I	102	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.533	-2.691	0.158	9.5	9.5	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.41	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K102L	102	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.533	-2.159	-0.374	14.629	14.629	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.175	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K102M	102	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.533	-3.711	1.178	4.301	4.301	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.56	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K102N	102	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.533	-3.632	1.099	10.61	10.61	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.905	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K102P	102	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.533	-3.221	0.688	17.923	17.923	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.74	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K102Q	102	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.533	-2.787	0.254	12.528	12.528	87.1	0.002771177	0	0.079204842	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
K102R	102	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.533	-3.068	0.535	29.965	29.965	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.935	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
K102S	102	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.533	-3.185	0.652	6.712	6.712	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.56	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K102T	102	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.533	-2.888	0.355	8.238	8.238	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.905	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K102V	102	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.533	-2.542	0.009	8.618	8.618	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.215	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K102W	102	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.533	-5.697	3.164	0.982	NA	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K102X	102	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K102Y	102	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys102Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	88.1	42	0.944	113.9	46.4	-52.5	-55.5	40.8695652173913	-2.9	1	0	25.31	0	0	1	4	5	20.1591452661069	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.533	-3.409	0.876	11.341	11.341	87.1	0.002771177	0	0.079204842	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.305	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P103A	103	P	A	missense	possibly_wt-like	0.731209902039625	0.39867966661721	6	0.162760292339179	0.412205590941624	1.05021421313763	NA	NA	0.823645766382064	0.632466804838181	0.909007667326332	-0.0254217614254758	1.0475943657441	0.999966569372545	0.708844414127114	NA	NA	0.698010873742304	0.573066572773752	0.719677954511924	0.278812046264399	0.851814676086026	0.796400809354572	p.Pro103Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.341	-2.411	0.07	12.506	12.506	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.28	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P103C	103	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.341	-5.476	3.135	1.071	NA	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103D	103	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.341	-2.558	0.217	13.29	13.29	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103E	103	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.341	-2.467	0.126	9.951	9.951	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.265	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P103F	103	P	F	missense	possibly_low	0.476754952587238	1.05534765196959	2	0.746243481217001	-0.985855394295875	1.93936529947035	NA	NA	NA	NA	-0.269488528629763	NA	NA	1.22299843380424	0.593941587761118	NA	NA	NA	NA	0.279465045615426	NA	NA	0.90841812990681	p.Pro103Phe	0	0	NA	NA	NA	NA	NA	NA	NA	2.375	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.341	-3.782	1.441	9.947	9.947	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103G	103	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.341	-3.861	1.52	3.383	NA	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103H	103	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.341	-3.716	1.375	25.564	25.564	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.21	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P103I	103	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.341	-3.328	0.987	7.883	7.883	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103K	103	P	K	missense	possibly_wt-like	0.921822573062483	0.336903458616527	7	0.127337538190981	0.672245584328166	1.1713995617968	0.625152683121184	1.11154389737428	1.15128062986144	1.39075430732798	0.59814539430945	0.519749611726034	NA	1.05613148771702	0.820626553312991	0.604545682505464	0.820626553312991	0.858700199282486	0.905614725668324	0.603559136360018	0.547512127451591	NA	0.824609530462717	p.Pro103Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.341	-2.487	0.146	10.863	10.863	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.345	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P103L	103	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.341	-2.836	0.495	10.902	10.902	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P103M	103	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.341	-4.198	1.857	4.461	4.461	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.815	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P103N	103	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.341	-2.996	0.655	11.003	11.003	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.28	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P103P	103	P	P	synonymous	possibly_wt-like	0.713220166241102	0.337664117492025	5	0.151007984054929	0.417249956115443	1.00919037636676	NA	NA	0.721312498519053	0.142804175151904	0.800375319496796	NA	0.879601325126367	1.02200751291139	0.679099663294361	NA	NA	0.647821270540125	0.358324271853578	0.679099663294361	NA	0.761334734358118	0.807470830420646	p.Pro103=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P103Q	103	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.341	-2.741	0.4	8.6	8.6	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.815	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P103R	103	P	R	missense	possibly_low	0.638751662613906	0.509238268904015	6	0.207895652718841	0.231283670742531	1.04621965448528	0.333949435723487	1.03017212791741	1.00394310671714	0.970510796617463	-0.253075111578083	NA	NA	0.747009620286021	0.695334979772043	0.465998015177981	0.783115537044368	0.786438148262054	0.721316286364173	0.28559607776474	NA	NA	0.669353673179913	p.Pro103Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.341	-3.026	0.685	13.488	13.488	43.18	0.003030005	0	0.086602594	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Oct 13, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P103S	103	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.341	-2.542	0.201	8.95	8.95	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.365	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P103T	103	P	T	missense	possibly_wt-like	0.847424420808465	0.319659693687652	2	0.226033537078553	0.404406828836303	1.29044201278063	NA	NA	NA	NA	0.621390883729912	NA	NA	1.07345795788702	0.722776961209892	NA	NA	NA	NA	0.612242205980113	NA	NA	0.833311716439672	p.Pro103Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.341	-2.921	0.58	14.401	14.401	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.35	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P103V	103	P	V	missense	possibly_low	0.683752900776068	0.549738552022122	6	0.224429824065111	0.24387852855179	1.12362727300035	0.728088205816633	1.02988900814803	1.05849946261602	NA	-0.348369550675429	NA	0.545216340505393	1.08919393824575	0.718252505377982	0.653519987160496	0.782985023595468	0.813195447348675	NA	0.25	NA	0.581237190960245	0.841215081999296	p.Pro103Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.341	-3.179	0.838	8.15	8.15	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P103W	103	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.341	-5.846	3.505	0.675	NA	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P103X	103	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P103Y	103	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro103Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	89.8	40.4	0.899	111.7	53.7	-56.7	-35.4	36.3636363636364	-2.5	1	0	28.52	0	0	0	0	6	20.7952734499934	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.341	-3.769	1.428	7.797	7.797	43.18	0.003030005	0	0.086602594	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F104A	104	F	A	missense	low	0.37750254671261	0.127453557146123	4	0.0637267785730613	0.252600355858651	0.502404737566569	0.213064415781342	0.346724402845559	0.504191069859416	0.446030298364122	NA	NA	NA	NA	0.479681096716214	0.408483761207636	0.468057637910042	0.541333531228359	0.491304555522386	NA	NA	NA	NA	p.Phe104Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.372	-2.804	1.432	7.403	7.403	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104C	104	F	C	missense	low	0.524930721719452	0.130661642567775	6	0.0533423922074945	0.420381554143553	0.629479889295351	0.614516786338964	0.675731499733307	0.411167310572766	0.619512612184003	0.350132883278558	NA	NA	0.478523238209113	0.550946200540116	0.59948537255947	0.619724372530953	0.495709799430584	0.567385491620175	0.510917081766825	NA	NA	0.534506909460056	p.Phe104Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.372	-3.293	1.921	17.989	17.989	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F104D	104	F	D	missense	low	0.184034913801665	0.107528524283872	5	0.0480882179637951	0.0897837385119143	0.278286089091415	0.0271781793179038	0.147206447616861	0.202948350275629	0.319684965865586	0.223156625932344	NA	NA	NA	0.393588297648063	0.320043454719152	0.376083218348807	0.393588297648063	0.435895615230898	0.463486646438335	NA	NA	NA	p.Phe104Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.372	-4.324	2.952	1.14	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104E	104	F	E	missense	low	0.182214570730232	0.173715303420013	3	0.100294577191902	-0.0143591884105687	0.378788329871032	-0.008491864949114	NA	NA	NA	0.331422205149856	NA	0.223713371989954	NA	0.408077816323891	0.303072485230223	NA	NA	NA	0.503927935705323	NA	0.408077816323891	NA	p.Phe104Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.372	-4.221	2.849	1.503	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104G	104	F	G	missense	low	0.182751289636521	0.141332825987119	7	0.0534187870931262	0.0780523908361805	0.287450188436861	0.155180355512516	0.203757809945344	0.197047610097068	0.412827551630204	-0.0710973598993958	0.21246391824843	NA	0.169079141921481	0.390694265097891	0.380943884515476	0.40215244464775	0.390694265097891	0.476743439769935	0.353571651802065	0.396059401113834	NA	0.37908921336011	p.Phe104Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.372	-3.981	2.609	2.003	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104H	104	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe104His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.372	-4.99	3.618	1.438	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104I	104	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe104Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.372	-1.94	0.568	8.538	7.883	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.49	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F104K	104	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe104Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.372	-4.191	2.819	1.848	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104L	104	F	L	missense	low	0.38606234691575	0.0841949249185034	5	0.0376531150956529	0.312263597422529	0.459861096408971	0.505531431205262	0.32631241253848	0.403218147600742	0.407886900529463	NA	NA	NA	0.287362842704806	0.474576709615141	0.547632699687281	0.458648053903273	0.491811112877454	0.474576709615141	NA	NA	NA	0.438496972249238	p.Phe104Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.372	-2.412	1.04	27.861	27.861	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.185	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F104M	104	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe104Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.372	-3.058	1.686	4.944	4.944	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.21	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F104N	104	F	N	missense	low	0.0458387187329455	0.119493390425608	5	0.0534390687707164	-0.0588999314250178	0.150577368890909	NA	-0.0261681032260183	0.225024261176875	NA	-0.0791342134151621	0.0997118717342059	0.0097597773948271	NA	0.340486996647222	NA	0.296160468227468	0.404415482507863	NA	0.350569582998881	0.340486996647222	0.292843823890279	NA	p.Phe104Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.372	-4.484	3.112	1.027	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104P	104	F	P	missense	possibly_low	0.262087372215374	0.647231748547108	3	0.373679424251745	-0.470310841081709	0.994485585512458	0.940699945934404	NA	NA	NA	-0.348369550675429	0.193931721387148	NA	NA	0.38692538739551	0.754675660742408	NA	NA	NA	0.25	0.38692538739551	NA	NA	p.Phe104Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.372	-4.52	3.148	1.061	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104Q	104	F	Q	missense	low	0.101541952390692	0.0224450158723997	2	0.0158710229272135	0.0704353190555439	0.13264858572584	NA	NA	NA	NA	0.0856709294634783	NA	0.117412975317905	NA	0.381477831532696	NA	NA	NA	NA	0.41213053805046	NA	0.350825125014933	NA	p.Phe104Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.372	-4.591	3.219	1.213	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104R	104	F	R	missense	low	0.338176263308374	0.292162077846497	8	0.103294893225405	0.13572199279967	0.540630533817078	0.159433629383795	0.599483299540589	0.853778817948962	0.508521560720623	-0.0385116251562448	0.15503176330302	0.284863924073621	0.182808736652628	0.413498987642187	0.382967492351709	0.584575235465692	0.71278970308095	0.518710194940773	0.36574365636944	0.36775266041434	0.441013099647619	0.385984875636754	p.Phe104Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.372	-4.46	3.088	1.815	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104S	104	F	S	missense	low	0.30105802053192	0.305298133876414	6	0.124637441236854	0.0567731245824599	0.545342916481381	0.0531171676590137	0.246884148679673	0.256464710152381	0.303474080004008	0.0606737701166378	NA	NA	0.885734246579808	0.420934244565913	0.332384616294825	0.422032961007015	0.419835528124811	0.428786306251979	0.402793153451357	NA	NA	0.73902784718925	p.Phe104Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.372	-3.936	2.564	2.153	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F104T	104	F	T	missense	low	0.239540411274567	0.0839619665982567	5	0.0375489329676537	0.165945855000057	0.313134967549077	0.229508603485961	0.184907610834015	0.335850705349383	0.311286597773114	NA	NA	NA	0.136148538930361	0.416307519589214	0.416307519589214	0.393462820097965	0.458770584944078	0.432212497960324	NA	NA	NA	0.362549881993113	p.Phe104Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.372	-3.882	2.51	2.493	NA	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104V	104	F	V	missense	low	0.33099407769285	0.13746660794785	7	0.0519574940293752	0.22915926066832	0.432828894717381	0.327733648565299	0.44161467393393	0.363625951700768	0.458424012203549	0.0791523257747208	NA	0.22249151380545	0.423916417866237	0.47239302290907	0.463040689601887	0.511800455920367	0.47239302290907	0.49673983782794	0.409695592989442	NA	0.407419731578671	0.507080740045776	p.Phe104Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.372	-2.5	1.128	7.415	7.415	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F104W	104	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe104Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.372	-3.826	2.454	12.691	12.691	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F104X	104	F	X	nonsense	low	0.00743537724526597	0.129722657426467	4	0.0648613287132334	-0.119690491022085	0.134561245512617	NA	0.199089494643152	-0.037572531298323	-0.0879596065383579	NA	NA	NA	-0.043815847825407	0.273893678729602	NA	0.400000429859127	0.275624239037185	0.257122459738659	NA	NA	NA	0.272163118422019	p.Phe104Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F104Y	104	F	Y	missense	possibly_wt-like	0.873782699977992	0.376042767172671	3	0.217108392853954	0.44825806924287	1.29930733071311	NA	NA	NA	NA	0.927579532595861	1.2200298160597	NA	0.473738751278418	0.726615248719565	NA	NA	NA	NA	0.726615248719565	0.892661115503729	NA	0.532103910195537	p.Phe104Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.4	91.6	38	0.91	108.1	50.3	-61.3	-44	0	-4.5	1	0	27.71	0	0	0	0	7	17.6693276006757	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.372	-2.949	1.577	9.687	9.687	74.19	0.002421127	0	0.069199837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C105A	105	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-1.497	-2.727	1.23	8.338	8.338	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C105D	105	C	D	missense	low	0.190625318665553	0.104211302614481	2	0.0736885187549827	0.0461984758316829	0.335052161499424	NA	NA	0.264313837420536	NA	NA	NA	NA	0.116936799910571	0.388292987660075	NA	NA	0.423685151920657	NA	NA	NA	NA	0.352900823399493	p.Cys105Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-1.497	-4.156	2.659	6.182	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105E	105	C	E	missense	low	0.0867387093602206	0.387182059876102	3	0.223539666494862	-0.351390986085803	0.524868404806244	NA	0.471091267867491	NA	NA	-0.303212139963958	NA	0.0923370001771281	NA	0.337319370483882	NA	0.525388669645663	NA	NA	0.266868001098131	NA	0.337319370483882	NA	p.Cys105Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-1.497	-4.141	2.644	3.672	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105F	105	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-1.497	-4.367	2.87	1.413	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C105G	105	C	G	missense	low	0.246432436944624	0.131497921822365	7	0.0497015427233988	0.149019203230684	0.343845670658565	0.253188238836256	0.202288979127776	0.228107324011521	0.41780597981739	0.094772455707779	0.108864510838786	NA	0.419999570272861	0.415530302391787	0.427573734064041	0.401475338360626	0.405927578266648	0.478926737124212	0.415530302391787	0.344998082503145	NA	0.505113510952572	p.Cys105Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-1.497	-3.3	1.803	13.031	13.031	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C105H	105	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-1.497	-5.195	3.698	2.377	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105I	105	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-1.497	-2.504	1.007	8.557	8.557	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.915	Deleterious	DAMAGING	effect	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C105K	105	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-1.497	-4.079	2.582	4.055	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105L	105	C	L	missense	low	0.297951167291114	0.218646874537252	4	0.109323437268626	0.083681167578484	0.512221167003745	NA	0.399525725010945	NA	NA	0.303694744424165	-0.00800771855213846	NA	0.496591918281486	0.492984419532867	NA	0.49239815880532	NA	NA	0.493570680260415	0.287394952418869	NA	0.543581868918339	p.Cys105Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-1.497	-2.772	1.275	9.504	9.504	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.26	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C105M	105	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-1.497	-3.331	1.834	4.542	4.542	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.315	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C105N	105	C	N	missense	low	0.159924237309272	0.1937288623741	3	0.111849410841487	-0.0592965796320658	0.37914505425061	NA	0.142128178986962	NA	NA	NA	-0.024292588856409	NA	0.361937121797263	0.373742221975445	NA	0.373742221975445	NA	NA	NA	0.279368584585971	NA	0.475951759023037	p.Cys105Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-1.497	-3.561	2.064	23.499	23.499	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105P	105	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-1.497	-4.343	2.846	1.429	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105Q	105	C	Q	missense	low	0.106934837808186	0.0653932145576999	2	0.0462399854573364	0.0163061316661509	0.197563543950221	NA	0.0606948523508497	0.153174823265523	NA	NA	NA	NA	NA	0.35268978882502	NA	0.33620282888317	0.36917674876687	NA	NA	NA	NA	NA	p.Cys105Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-1.497	-4.508	3.011	2.543	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C105R	105	C	R	missense	low	0.102351191791716	0.182281014806094	6	0.0744159126786058	-0.0435013169350291	0.248203700518461	NA	NA	0.257396090552114	0.196467288484757	-0.226316806225134	0.0384305133899601	0.247688485141144	0.100441579407455	0.363237221932113	NA	NA	0.42029232593523	0.381858312911643	0.295591317017087	0.31028308871425	0.420990653860869	0.344616130952584	p.Cys105Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-1.497	-4.391	2.894	3.288	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	1	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C105S	105	C	S	missense	low	0.279739062411762	0.119621614628105	6	0.0488353196744508	0.184023594676338	0.375454530147186	0.290222851229843	0.448044968766638	0.382414377580051	0.241379107559469	NA	0.130382533103347	NA	0.185990536231224	0.423374196705612	0.445193933025976	0.51476471361922	0.481607852644959	0.401554460385248	NA	0.355603728019804	NA	0.387582928292758	p.Cys105Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-1.497	-2.494	0.997	6.658	6.658	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	medium	2.53	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
C105T	105	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-1.497	-2.344	0.847	7.506	7.506	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.425	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C105V	105	C	V	missense	wt-like	1.08993402720699	0.38521483120078	4	0.19260741560039	0.712430429474883	1.46743762493909	NA	0.947869591259855	0.808127259985448	0.94428003017268	1.65945922740996	NA	NA	NA	0.727494098036707	NA	0.74517545276063	0.690399784068325	0.709812743312784	1	NA	NA	NA	p.Cys105Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-1.497	-2.122	0.625	8.017	8.017	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.98	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
C105W	105	C	W	missense	low	0.146715646930919	0.0903751966096592	7	0.0341586135596752	0.0797659945921342	0.213665299269704	NA	0.106647210335124	0.223141071444672	0.25403358588719	0.0458244206559096	0.0516840689347793	0.104036856300182	0.241642314958576	0.397246359712218	NA	0.357386092556002	0.403491867466661	0.407104101359035	0.397246359712218	0.316815404287471	0.343620835689501	0.415533926025251	p.Cys105Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-1.497	-5.604	4.107	0.269	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C105X	105	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C105Y	105	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys105Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	92.9	41	0.826	111.2	46.8	-63.8	-36	0	-4.8	1	0	30.76	0	0	0	0	9	19.2340676368781	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-1.497	-4.512	3.015	1.164	NA	74.19	0.002183151	0	0.0623981	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	5	5	0	0	0	0	1	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.26	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E106A	106	E	A	missense	possibly_low	0.576071225584197	0.202809827194616	8	0.0717041020502922	0.43553376802184	0.716608683146555	0.791008473199196	0.491725500677339	0.41809785819554	0.339300687177402	0.612609506267819	0.354373390092761	0.833659721603023	0.767794667460496	0.571931366512686	0.683455972941487	0.534900703705965	0.499108903577502	0.444498120044073	0.608962029319407	0.466002704235889	0.736590890241756	0.679792922737232	p.Glu106Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.182	-2.503	0.321	10.206	10.206	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	0.82	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E106C	106	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu106Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.182	-3.993	1.811	11.393	11.393	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E106D	106	E	D	missense	possibly_wt-like	0.795346850170004	0.40192971105285	6	0.16408711742396	0.473742009692047	1.11695169064796	1.02123660671254	0.935843425416261	0.707572326130981	0.947171641553227	NA	1.13401438093451	NA	0.0262427202724995	0.725356228321047	0.792993112848005	0.739631592701801	0.64108236915949	0.711080863940294	NA	0.850266456613477	NA	0.307349898122986	p.Glu106Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.182	-2.689	0.507	17.916	17.916	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E106E	106	E	E	synonymous	possibly_wt-like	0.824167958319224	0.462839980391681	5	0.206988331772094	0.418478282825892	1.22985763381256	NA	0.749623271045358	1.09303938302505	1.13252767959185	NA	0.0448085924777234	NA	1.10084086545614	0.792369040094074	NA	0.653787235539885	0.830135636362128	0.792369040094074	NA	0.313426669711163	NA	0.847064728560332	p.Glu106=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E106F	106	E	F	missense	possibly_low	0.600994570448247	0.192740804042935	8	0.0681441647750534	0.467434461732579	0.734554679163914	0.910486866238639	0.510042190125336	0.53897119496784	0.725518360131696	0.454697969005028	0.817921458579925	0.368873601282966	0.481444923254545	0.554183812981072	0.74030098686073	0.543344389279686	0.558391529228098	0.61387447575939	0.549976096734045	0.694472887687821	0.486260156731241	0.53597432009719	p.Glu106Phe	0	0	NA	NA	NA	NA	NA	NA	NA	0.478	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.182	-3.958	1.776	9.756	9.756	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E106G	106	E	G	missense	low	0.414662940005603	0.14823680764095	8	0.0524096259521809	0.311941960696113	0.517383919315094	0.61659138119803	0.426124267141614	0.514626740015891	0.51362092425254	0.143035459522612	0.3521818168596	0.296872434778564	0.454250496275976	0.512803083881346	0.60047241607956	0.504659639085825	0.546451731352716	0.520946528676868	0.433558359991221	0.464922537641166	0.447480804171729	0.52231597198691	p.Glu106Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.182	-3.469	1.287	29.858	29.858	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E106H	106	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu106His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.182	-3.491	1.309	13.88	13.88	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.65	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E106I	106	E	I	missense	possibly_wt-like	0.781612064887018	0.268902775885811	7	0.101635695978399	0.582409761225693	0.980814368548342	1.2269900487356	0.734407865275116	0.439609628975867	0.77682588494974	0.660534574696938	NA	0.593763827408453	1.03915262416741	0.636375469843837	0.890885769237114	0.646773189548373	0.509659404525895	0.636375469843837	0.626863855268985	NA	0.607384546647558	0.81608192923544	p.Glu106Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.182	-3.412	1.23	7.614	7.614	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E106K	106	E	K	missense	possibly_wt-like	0.80973381922875	0.215966151003372	7	0.0816275324518208	0.649746795476307	0.969720842981193	0.973668873467728	0.775869851558313	0.75923492046559	1.20706780161143	NA	0.744555765432464	0.638468662877747	0.569270859187976	0.665886467437983	0.770361502314747	0.665886467437983	0.666420415761503	0.825058725487485	NA	0.658312941153727	0.631462275661473	0.580084725770943	p.Glu106Lys	1	0	NA	NA	NA	NA	NA	NA	NA	-0.979	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.182	-2.344	0.162	20.007	20.007	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.37	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E106L	106	E	L	missense	wt-like	0.97952614869448	0.112929791658173	8	0.039926710739739	0.901271233623443	1.05778106376552	0.908198609322821	0.97155954942901	0.971784153869822	1.15040554798059	1.11211187429127	0.798083858014113	1.00532747844222	0.918738118205984	0.763380917718521	0.739212287951066	0.756096124785063	0.77066571065198	0.800209406829443	0.795545058762199	0.684695476134131	0.829050009847285	0.75560397758584	p.Glu106Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.182	-2.963	0.781	14.257	14.257	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E106M	106	E	M	missense	wt-like	1.00209708800766	0.14810176250327	6	0.0604622913566449	0.883593174525869	1.12060100148945	NA	0.971732497481289	1.09608092888829	0.993772096091501	1.20473902651792	NA	0.98608271456429	0.760175264502669	0.78743037905073	NA	0.756175850926524	0.831627370020062	0.73151756509898	0.830144803983616	NA	0.818684907174936	0.675966092406425	p.Glu106Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.182	-3.358	1.176	6.23	6.23	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E106N	106	E	N	missense	wt-like	1.00974122732354	0.306298897967844	8	0.108293013911514	0.797490820279672	1.2219916343674	0.746685325458616	1.12479655747617	0.884413380312299	1.05787486770874	1.65945922740996	0.672179509382097	0.875677622267767	1.05684332857264	0.759425694155075	0.662368060004574	0.82673580658354	0.727814499624597	0.759629934387331	1	0.622640661143246	0.759221453922819	0.82496705114932	p.Glu106Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.182	-2.747	0.565	17.369	17.369	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.425	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E106P	106	E	P	missense	low	0.20146307723063	0.121639827392775	8	0.0430061734058963	0.117172526242189	0.285753628219071	0.115143649896575	0.129429273936416	0.313303561729732	0.437222847245537	0.203052246107796	0.0596006302722815	0.149442910206236	0.20450949845047	0.38248013870241	0.361895360090917	0.367888240464115	0.447712282837204	0.487442034260229	0.455976900073016	0.320717261169305	0.368076236320426	0.396884041084394	p.Glu106Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.182	-4.349	2.167	1.958	NA	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E106Q	106	E	Q	missense	wt-like	1.02858396424922	0.146671175758597	4	0.0733355878792983	0.884848853220725	1.17231907527772	NA	NA	0.944670463489648	NA	NA	1.24749038719938	0.945851702290675	0.976323304017184	0.790771387522341	NA	NA	0.75736773444204	NA	NA	0.90619568106983	0.797016749775164	0.784526025269519	p.Glu106Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.182	-2.603	0.421	10.882	10.882	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
E106R	106	E	R	missense	low	0.613472010659015	0.126063889758682	8	0.0445703156555587	0.526115797194539	0.700828224123492	0.655729149564215	0.612898575017044	0.658577850230766	0.839202420304183	0.443197768001626	0.616307355117368	0.448887016432484	0.632975950604439	0.603591643164647	0.619093247268756	0.590759451687168	0.617052907813428	0.663730795558653	0.545680336634035	0.595102802175616	0.529354853473191	0.612080484153679	p.Glu106Arg	0	0	NA	NA	NA	NA	NA	NA	NA	2.166	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.182	-2.505	0.323	11.952	11.952	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E106S	106	E	S	missense	possibly_wt-like	0.727250819895505	0.14429494111353	8	0.0510159656761452	0.627261364533729	0.827240275257281	0.898547359770664	0.566039849364028	0.522877520985795	0.803829100537229	0.744670630992901	0.807793174662493	0.870910768509393	0.603338154341534	0.653254813309801	0.734620450036495	0.569158367772815	0.55049834719559	0.648217771657263	0.658291854962338	0.68948093314852	0.756654057983695	0.597194958567892	p.Glu106Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.182	-3.077	0.895	8.131	8.131	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E106T	106	E	T	missense	possibly_wt-like	0.71012302614212	0.197690128169381	7	0.0747198451126667	0.563674820790882	0.856571231493358	0.449363746633515	0.805300240023585	0.823084440215209	0.991469268198184	0.521479059835308	NA	0.569399958824078	0.81076446926496	0.679453381220015	0.520909434249332	0.679453381220015	0.697735569941597	0.730507656377232	0.574921360328918	NA	0.594262328002818	0.701374422201722	p.Glu106Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.182	-3.015	0.833	9.275	9.275	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.075	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E106V	106	E	V	missense	wt-like	0.859760423013728	0.195975378089171	8	0.0692877593962252	0.72395891002765	0.995561935999807	0.456878086347928	1.06968261946599	0.788305291883299	0.917497404760936	1.06343890592753	0.949347483449779	0.836012883695584	0.796920708578781	0.717962734729055	0.524484580640184	0.801329208704117	0.680678051004305	0.698067181660906	0.777363863895763	0.759249186099266	0.737858287797205	0.694421420295991	p.Glu106Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.182	-3.021	0.839	10.021	10.021	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E106W	106	E	W	missense	low	0.499426917693719	0.0646697283842652	6	0.0264013060576386	0.447681308675928	0.55117252671151	0.530753911533129	0.479666153314921	0.428953629393627	0.577042861113558	NA	0.554776688082174	0.425368262724903	NA	0.53905093217948	0.559632963574678	0.529341547525388	0.504433143292147	0.548760316833572	NA	0.5647760167975	0.516687808117323	NA	p.Glu106Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.182	-5.798	3.616	0.839	NA	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E106X	106	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu106Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E106Y	106	E	Y	missense	low	0.452286339368567	0.188033856967669	4	0.0940169284838343	0.268016545603174	0.63655613313396	NA	0.332516046601875	NA	0.731633534398564	0.350611570251804	NA	0.394384206222026	NA	0.505547944729461	NA	0.461507824802073	NA	0.616556294858871	0.511095889458922	NA	0.5	NA	p.Glu106Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.5	94.3	42.8	0.897	111.9	52.1	-73.8	-39.3	40.6542056074766	-4.3	1	0	31.48	0	0	1	4	8	22.684277768093	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.182	-3.937	1.755	9.687	9.687	72.21	0.00343393	0	0.098147443	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D107A	107	D	A	missense	low	0.266977275853626	0.15108160105002	7	0.0571034777222612	0.155056516126009	0.378898035581243	0.229425253729216	0.312159177311039	0.442535991488411	0.476298785828147	0.0741228781830784	NA	0.196661842253831	0.137637002181658	0.416267863732102	0.416267863732102	0.45212365065613	0.511094646225856	0.504578847349726	0.407816904061928	NA	0.393508041140497	0.363297459768942	p.Asp107Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.822	-2.577	0.755	8.985	8.985	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	1.94	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D107C	107	D	C	missense	low	0.159687733687079	0.147758711700011	5	0.0660797047258037	0.0301738923154622	0.289201575058695	0.214841611561987	-0.0919119189559814	0.176219651323185	0.29722832427825	NA	NA	NA	0.202061000227951	0.39565428760965	0.409329309229484	0.265853675615379	0.380479141431832	0.426047220452449	NA	NA	NA	0.39565428760965	p.Asp107Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.822	-4.16	2.338	11.033	11.033	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107E	107	D	E	missense	low	0.403311093554165	0.228533985469278	6	0.093298608880726	0.220449180340254	0.586173006768077	0.338357227886218	0.509432309502727	0.509383681739771	0.51611912047297	-0.0331999837937314	NA	NA	0.579774205517037	0.53255268052813	0.468095139189022	0.543063244576686	0.543880260511028	0.522042116479574	0.367727755345093	NA	NA	0.585360011056351	p.Asp107Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.822	-2.186	0.364	9.951	9.951	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.595	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
D107F	107	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.822	-4.612	2.79	2.933	NA	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107G	107	D	G	missense	low	0.382168132728391	0.17522484910856	7	0.0662287677514383	0.252362133195104	0.511974132261678	0.498595072721927	0.191290678942961	0.260976665678981	0.421069161118345	0.645929845701151	0.474834746611497	NA	0.182480758323876	0.480357810312982	0.544332543194518	0.396405307071968	0.422048427822777	0.480357810312982	0.621408436526912	0.525374817062342	NA	0.385820149158411	p.Asp107Gly	1	0	NA	NA	NA	NA	NA	NA	NA	0.555	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.822	-3.3	1.478	10.501	10.501	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.68	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D107H	107	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.822	-3.18	1.358	11.245	11.245	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	3	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.515	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D107I	107	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.822	-3.514	1.692	7.007	7.007	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107K	107	D	K	missense	low	0.0954194790934323	0.117963222385363	2	0.083412594479307	-0.0680662019430538	0.258905160129918	NA	0.0120068846141254	NA	NA	NA	NA	NA	0.178832073572739	0.348873049742619	NA	0.313758495153565	NA	NA	NA	NA	NA	0.383987604331673	p.Asp107Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.822	-2.744	0.922	8.663	8.663	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107L	107	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.822	-3.453	1.631	10.529	10.529	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107M	107	D	M	missense	low	0.185168841615662	0.194409194834141	8	0.0687340299961188	0.0504526183109737	0.319885064920351	0.357224464228258	0.13052812614794	0.290075668714537	0.455587271553867	-0.162003573467198	0.08415498825855	0.0731165591772889	0.252667228312056	0.39473298008784	0.477071727216339	0.368394792840429	0.436320105513053	0.495495780844018	0.31961474226874	0.332819433640815	0.326967367952972	0.421071167335251	p.Asp107Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.822	-4.088	2.266	5.104	5.104	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107N	107	D	N	missense	low	0.544114521505521	0.130342592841822	4	0.0651712964209109	0.416381127694752	0.671847915316291	0.665485070378942	0.614643706895728	0.528319642974915	NA	NA	NA	NA	0.368009665772499	0.572365688719461	0.623734885312257	0.591563928113441	0.553167449325481	NA	NA	NA	NA	0.479001682435437	p.Asp107Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.822	-2.709	0.887	18.547	18.547	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	1	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D107P	107	D	P	missense	low	0.196410166377694	0.083825642703389	5	0.0374879670684774	0.122935101069855	0.269885231685533	0.0638575715970815	0.207505967581581	0.225963156351653	0.293923257732784	NA	NA	NA	0.190800878625369	0.403880282238215	0.337494648291624	0.403880282238215	0.404875965958207	0.424597778425144	NA	NA	NA	0.389998913413556	p.Asp107Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.822	-4.249	2.427	1.134	NA	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107Q	107	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.822	-3.632	1.81	5.255	5.255	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107R	107	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp107Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.822	-3.146	1.324	9.476	9.476	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107S	107	D	S	missense	possibly_low	0.563997268640883	0.285001419276726	4	0.142500709638363	0.284701009978292	0.843293527303475	NA	0.355251084843168	0.508400039974233	0.98083780529455	NA	NA	NA	0.411500144451583	0.522121260916788	NA	0.471988294810642	0.543397830985065	0.725845211935563	NA	NA	NA	0.500844690848512	p.Asp107Ser	0	0	NA	NA	NA	NA	NA	NA	NA	0.042	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.822	-2.049	0.227	8.568	8.568	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.035	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D107T	107	D	T	missense	possibly_low	0.447517877019057	0.362304580850704	7	0.136938259970065	0.179123819372146	0.715911934665968	0.408588773283808	0.054454640749751	0.249649107898313	0.543191020709216	0.181915288714382	0.536856498066294	NA	1.15796980971163	0.501509659372417	0.501509659372417	0.333326196355073	0.416492799217009	0.53391454005157	0.448081446925772	0.555943644539357	NA	0.875757629809151	p.Asp107Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.822	-3	1.178	6.224	6.224	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107V	107	D	V	missense	low	0.172984054918225	0.121182475172257	8	0.0428444749776365	0.0890104270255299	0.25695768281092	0.197174332342945	0.191228743590134	0.273631144375161	0.355000981113588	-0.053938395221054	0.103886965922331	0.127401647504485	0.189487019718208	0.392857893123484	0.400923632624928	0.396376755916659	0.428254848058882	0.451383508147183	0.35998117419223	0.342544786550658	0.356204957858351	0.389339030330308	p.Asp107Val	1	0	NA	NA	NA	NA	NA	NA	NA	-1.251	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.822	-3.506	1.684	5.545	5.545	58.56	0.002690256	0	0.076891988	0	NA	NA	PTEN hamartoma tumor syndrome|not provided	Pathogenic(Last reviewed: Mar 1, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D107W	107	D	W	missense	low	0.269467450809131	0.231111964883766	4	0.115555982441883	0.042981887024897	0.495953014593364	-0.0042266963604967	0.160109931236518	0.462779055486679	0.459207512873822	NA	NA	NA	NA	0.439557475195977	0.305101752293665	0.38203150713753	0.521022906809007	0.497083443254424	NA	NA	NA	NA	p.Asp107Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.822	-5.812	3.99	0.614	NA	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D107X	107	D	X	nonsense	low	0.0131740896586198	0.15554761601328	3	0.0898054579770717	-0.162841373591566	0.189189552908806	-0.11609133626715	-0.030188095834796	NA	NA	0.185801701077806	NA	NA	NA	0.294307319289524	0.251879183335396	0.294307319289524	NA	NA	0.449533168957243	NA	NA	NA	p.Asp107Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D107Y	107	D	Y	missense	low	0.267447089159155	0.0472775061463586	4	0.0236387530731793	0.221115984496288	0.313778193822022	NA	0.334510013080632	0.257586265186804	0.254253440468562	NA	NA	NA	0.223438637900623	0.413793058238812	NA	0.462427009791204	0.420385597553088	0.407200518924537	NA	NA	NA	0.406391164593264	p.Asp107Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.7	95.9	39.6	0.977	114.5	40.8	-57.6	-59.8	18.716577540107	-5.2	1	0	32.88	1	39	1	41	7	21.5771781718556	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.822	-3.858	2.036	7.088	7.088	58.56	0.002690256	0	0.076891988	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	5	0	0	1	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L108A	108	L	A	missense	low	0.266124260083495	0.144843366307738	8	0.0512098632630444	0.165754772434708	0.366493747732283	0.160563983808812	0.364621490009051	0.378920714019121	0.514126882269793	0.0788389648379939	0.272465614601762	0.209220933906872	0.150235497214559	0.417605569712475	0.383505288445121	0.476307893892328	0.479894376748932	0.52116841734512	0.409578540825876	0.425632598599075	0.400272284925502	0.369625029419908	p.Leu108Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.153	-1.836	-0.317	10.494	10.494	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.09	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L108C	108	L	C	missense	possibly_low	0.697249752686594	0.417762698225759	3	0.241195406278026	0.224515443145156	1.16998406222803	NA	NA	0.487860276461186	NA	1.17829898786743	NA	NA	0.42558999373117	0.533324053394317	NA	NA	0.533324053394317	NA	0.820268449383908	NA	NA	0.507921290272123	p.Leu108Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.153	-3.641	1.488	10.913	10.913	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L108D	108	L	D	missense	low	0.124295597747836	0.201673996365806	2	0.142605050419253	-0.155205165087418	0.40379636058309	NA	NA	NA	NA	-0.0183094526714171	NA	NA	0.266900648167089	0.400754903397027	NA	NA	NA	NA	0.373289931992638	NA	NA	0.428219874801417	p.Leu108Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.153	-4.279	2.126	2.857	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108E	108	L	E	missense	low	0.269458986683135	0.243938818173879	8	0.0862453962626911	0.100421116175875	0.438496857190395	0.183991821297153	0.334371778631929	0.718373794706701	0.472847919854519	-0.034024017825935	0.0256757521021881	0.167920457148652	0.286514387549872	0.416361270352991	0.394651703409733	0.462363286036777	0.646379976019284	0.503065464758494	0.367419947462818	0.303996615208248	0.378028121020393	0.43807083729625	p.Leu108Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.153	-4.077	1.924	3.01	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108F	108	L	F	missense	low	-0.12385638896582	0.317509558220994	2	0.224513161709609	-0.563894099971871	0.316181322040232	NA	NA	NA	NA	-0.348369550675429	0.10065677274379	NA	NA	0.295476356274792	NA	NA	NA	NA	0.25	0.340952712549584	NA	NA	p.Leu108Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.153	-3.603	1.45	10.808	10.808	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.81	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L108G	108	L	G	missense	low	0.196560840449039	0.105872047307283	8	0.0374314212945413	0.123196602821593	0.269925078076486	0.406310059192158	0.183826780168125	0.271259499507279	0.241251819855204	0.122314696325044	0.116119059177827	0.0868179357860049	0.144586873580672	0.397231606758629	0.500425500714415	0.392964575350893	0.427091668993645	0.401498638166366	0.425818371119762	0.348573651257623	0.334346838867899	0.366788019175258	p.Leu108Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.153	-3.865	1.712	3.907	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108H	108	L	H	missense	low	0.404526989643471	0.348487631604669	8	0.12320898373365	0.163041818953735	0.646012160333207	0.0977747811764924	0.977840058650613	0.768158111233354	0.591400939412657	0.456583414397046	0.0543707177515933	0.154764101989709	0.135323792536302	0.460811288483587	0.353631660194747	0.758991333838021	0.670796816645436	0.555057074200407	0.550680381909877	0.318139580116855	0.370942195057296	0.362135654719208	p.Leu108His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.153	-5.222	3.069	1.126	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L108I	108	L	I	missense	possibly_wt-like	0.755166517542713	0.373733989325801	6	0.152576262230498	0.456122538675198	1.05421049641023	1.17377228862831	0.767565266785782	0.939763201640018	0.828770097884761	0.0598463519952423	NA	NA	0.761281898322163	0.669290045356192	0.865566008591763	0.662058193620345	0.754960955784567	0.659155684483252	0.402484081483757	NA	NA	0.676521897092038	p.Leu108Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.153	-2.271	0.118	9.096	9.096	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	-0.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
L108K	108	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu108Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.153	-4.041	1.888	3.16	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108L	108	L	L	synonymous	wt-like	1.12707895831195	0.224822626419253	7	0.0849749655151033	0.960531086314815	1.29362683030909	1.24279536201549	0.98063511993456	0.764398301458122	0.976370168017089	1.37006718044902	1.34765145535016	1.20763512095921	NA	0.891901123447552	0.898405566168906	0.760279810050272	0.668952808683263	0.723885922721981	0.891901123447552	0.955562336160927	0.938011569437719	NA	p.Leu108=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L108M	108	L	M	missense	possibly_wt-like	0.795890687814713	0.482870276313321	5	0.215946152430138	0.372644006451645	1.21913736917778	1.02281151178342	NA	1.08104514641771	0.932288811118872	-0.0626611666353146	NA	NA	1.00596913638888	0.793742415700163	0.793742415700163	NA	0.824253033484234	0.704553975715791	0.356722889107317	NA	NA	0.799415586975331	p.Leu108Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.153	-2.327	0.174	8.239	8.239	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.36	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L108N	108	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu108Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.153	-4.4	2.247	3.206	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108P	108	L	P	missense	low	0.128543874392062	0.165674435041931	7	0.0626190505317247	0.00581279060378759	0.251274958180336	0.0916608973170309	0.109981692347694	0.288019908408539	0.354751422571102	-0.160834574259309	NA	0.0780632101411846	0.138164564218191	0.358923232645935	0.350722817815381	0.358923232645935	0.435311852809006	0.451274063863755	0.320051407693345	NA	0.32963160147905	0.36356242677672	p.Leu108Pro	1	0	NA	NA	NA	NA	NA	NA	NA	22.758	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.153	-4.325	2.172	1.698	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	not provided|Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic(Last reviewed: Dec 1, 2014)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	2	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L108Q	108	L	Q	missense	low	0.176894599689518	0.130646168290441	4	0.0653230841452204	0.0488637074058067	0.304925491973229	NA	0.121120711207852	0.369880934520759	NA	NA	NA	0.0814818093870306	0.13509494364243	0.363039424341308	NA	0.364058132875693	0.475460794634997	NA	NA	NA	0.331472836445795	0.362020715806922	p.Leu108Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.153	-3.708	1.555	5.043	5.043	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L108R	108	L	R	missense	low	0.131785989754922	0.0663045927622782	8	0.0234422135830097	0.0858400954143272	0.177731884095516	0.131405292400486	0.172888049488023	0.175610853730752	0.250040529908873	0.0700080132274263	0.0662786928661057	0.060705617582158	0.12735086883555	0.374906411452964	0.369632267752367	0.387922004601379	0.38018055515356	0.40535294050562	0.406279846345442	0.324008695843801	0.320282916810313	0.35813126928217	p.Leu108Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.153	-4.35	2.197	2.309	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	1	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L108S	108	L	S	missense	low	0.12896946267338	0.157805889048547	6	0.0644239844291993	0.0027007734515806	0.25523815189518	NA	0.0277838078603077	0.222613323039802	0.382253522327731	-0.0498071060986985	NA	0.0356965437862905	0.15527668512485	0.366840661604458	NA	0.321031391251395	0.403233031961999	0.463335152098441	0.361524366956267	NA	0.306813194901606	0.37215695625265	p.Leu108Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.153	-3.173	1.02	12.824	12.824	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
L108T	108	L	T	missense	low	0.282105301519354	0.195205663518265	7	0.0737808057400977	0.137497579518416	0.426713023520291	0.115222470170385	0.285148462721122	0.345752986670732	0.451667833423023	-0.0366442126720098	NA	0.273990984991746	0.539598585330479	0.439672165808593	0.361932860926406	0.439672165808593	0.463627183200865	0.493776905211073	0.366441205572073	NA	0.435157006496846	0.565181883880263	p.Leu108Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.153	-2.993	0.84	6.59	6.59	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L108V	108	L	V	missense	wt-like	1.05074409081641	0.161760746736979	5	0.0723416051590023	0.908957150120945	1.19253103151187	1.24862906178824	0.839206501464177	1.09038066603198	1.13483687483071	NA	0.940667349966917	NA	NA	0.793381741225024	0.901181103538858	0.695083597116701	0.828831662066227	0.793381741225024	NA	0.754970985360152	NA	NA	p.Leu108Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.153	-1.647	-0.506	14.697	14.697	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	-1.095	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
L108W	108	L	W	missense	low	0.188370114395472	0.148718394436513	7	0.0562102695799748	0.0782000104574338	0.29854021833351	0.150633734944621	0.243687736180762	0.217867822122373	0.35506691527466	-0.119124627150752	NA	0.252783990710681	0.217675228685958	0.403496503513701	0.378780709209107	0.420559468639229	0.400905589352034	0.45141242367514	0.335631650726443	NA	0.423735059494047	0.403496503513701	p.Leu108Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.153	-5.622	3.469	0.502	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L108X	108	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu108Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L108Y	108	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu108Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	97.7	39	0.905	116.4	49.8	-56.6	-45.8	0	-5.6	1	0	38.67	0	0	0	0	7	20.005376723771	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.153	-4.425	2.272	2.507	NA	58.31	0.003214979	0	0.091889447	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109A	109	D	A	missense	wt-like	0.870045122662822	0.108964661233161	8	0.0385248254338314	0.794537852301819	0.945552393023824	1.08791876562205	0.874443521401417	0.716642610370815	0.81855035011412	0.822670849267561	0.902804552758508	0.813350346002185	0.923979985765918	0.718489832506862	0.824718918284012	0.711327270284264	0.645530912398994	0.654673798347695	0.687427887050582	0.736309446649744	0.72565239472946	0.758236695382687	p.Asp109Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.194	-2.665	0.471	11.572	11.572	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D109C	109	D	C	missense	possibly_low	0.683809018689838	0.33828496582297	3	0.195308916080695	0.30101057731212	1.06660746006756	0.717102723970837	NA	NA	NA	0.330108216371628	NA	NA	1.00421611572705	0.648293352849909	0.648293352849909	NA	NA	NA	0.503437111191586	NA	NA	0.798535135754107	p.Asp109Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.194	-4.346	2.152	10.074	10.074	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D109D	109	D	D	synonymous	wt-like	1.24949195804827	0.0654439416334761	4	0.032721970816738	1.18535807374429	1.31362584235224	1.15476380573109	1.29653558415161	1.25712780466229	1.28954063764808	NA	NA	NA	NA	0.883565961213935	0.856522218770124	0.905904607588838	0.910613206794744	0.861227314839032	NA	NA	NA	NA	p.Asp109=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D109E	109	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.194	-2.603	0.409	15.111	15.111	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.37	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D109F	109	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.194	-3.112	0.918	13.008	13.008	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109G	109	D	G	missense	possibly_wt-like	0.720275540055482	0.228462746343023	8	0.080773778593827	0.561961843116369	0.878589236994596	0.19652555620933	0.837982130647213	0.752367748058322	0.820316307212369	0.770525138720517	0.911656810471276	0.851495364607019	0.621335264517813	0.665500942879095	0.400614960174557	0.694519182775702	0.663052394145081	0.655448261554837	0.66794949161311	0.740672482721063	0.746197049721621	0.606233972184924	p.Asp109Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.194	-3.221	1.027	17.586	17.586	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.25	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D109H	109	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.194	-2.572	0.378	15.989	15.989	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.1	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D109I	109	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.194	-3.484	1.29	7.816	7.816	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109K	109	D	K	missense	possibly_wt-like	0.842197062236801	0.21809030074804	8	0.0771065652849763	0.691070971306661	0.993323153166941	0.431933877423216	0.831003655665779	0.868209864056728	0.973434943410034	1.15995054734215	0.90148228927887	0.652074268885859	0.919487051831771	0.72123306031267	0.512616711752278	0.691302223253917	0.719867445178571	0.722598675446769	0.813414612769872	0.735657739091667	0.638790165163682	0.755980128044187	p.Asp109Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.194	-2.566	0.372	10.794	10.794	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D109L	109	D	L	missense	low	0.458467562601735	0.304247688512262	6	0.124208598712713	0.21502318255463	0.701911942648841	0.553955066059524	0.267992119946632	0.562592735845201	0.659638921466624	-0.0614202041677775	NA	NA	0.768046736460209	0.570324150112155	0.57067152810877	0.431763380523235	0.569976772115541	0.584982946398999	0.357186435531599	NA	NA	0.679919523902559	p.Asp109Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.194	-3.154	0.96	10.529	10.529	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D109M	109	D	M	missense	possibly_low	0.65253841804841	0.143356495281563	4	0.0716782476407817	0.512051634197534	0.793025201899285	0.730148830181746	NA	NA	NA	NA	0.457794463240736	0.637469135706423	0.784741243064733	0.642712160389297	0.654500383847607	NA	NA	NA	NA	0.516976126759314	0.630923936930986	0.688304307406681	p.Asp109Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.194	-3.966	1.772	7.797	7.797	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109N	109	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.194	-2.788	0.594	11.789	11.789	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.905	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D109P	109	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.194	-4.403	2.209	1.331	NA	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109Q	109	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.194	-2.861	0.667	8.653	8.653	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D109R	109	D	R	missense	possibly_wt-like	0.724096564632884	0.119229790054463	8	0.0421540965334795	0.641476053626439	0.806717075639328	0.753077345918013	0.731462553020348	0.785974872948255	0.956166901613037	0.656284047287748	0.548727496394846	0.650679703509384	0.710399596371438	0.64819090498529	0.665409233247225	0.645415450167231	0.679535091299341	0.715025749103077	0.625276122494315	0.56179453541834	0.638039061465962	0.650966359803349	p.Asp109Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.194	-2.832	0.638	10.5	10.5	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D109S	109	D	S	missense	possibly_wt-like	0.804125994155638	0.196242149466036	8	0.0693820773210289	0.668139621433849	0.940112366877428	0.388183318856097	0.682416004462879	0.859898051903229	1.01136583143997	0.790982072226753	0.828552202905021	0.924667067080103	0.94694340437105	0.707751693840641	0.491801223299052	0.622805816714019	0.715790896441423	0.739233324851633	0.675590930114807	0.699712491239858	0.785606845220004	0.769770027758403	p.Asp109Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.194	-2.839	0.645	6.385	6.385	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D109T	109	D	T	missense	possibly_wt-like	0.809855645955995	0.196460787252227	7	0.0742551979207659	0.6643181323664	0.955393159545589	0.9490278491658	0.78674660209156	0.617608524883478	0.859355269866528	0.903372282701297	0.492458592427809	NA	1.06042040055549	0.672568858793923	0.758637881551241	0.670900466382895	0.596959401316655	0.672568858793923	0.717572925181282	0.534061129357683	NA	0.826763628602335	p.Asp109Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.194	-3.316	1.122	7.75	7.75	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D109V	109	D	V	missense	possibly_low	0.654590235624376	0.197705915545614	4	0.0988529577728072	0.460841998624415	0.848338472624337	NA	0.802098699399762	0.843548060327509	NA	NA	0.526321444764224	NA	0.446392738006011	0.614364364676098	NA	0.677977524872949	0.707772002813958	NA	NA	0.550751204479246	NA	0.518369428163714	p.Asp109Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.194	-3.465	1.271	8.017	8.017	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D109W	109	D	W	missense	low	0.499961385940835	0.168492814844283	7	0.0636842979684608	0.375142455541935	0.624780316339736	0.673547334469723	0.201279969701458	0.52710101742098	NA	0.575806604101802	0.351038372764867	0.523418029493135	0.647538373633882	0.569496764672921	0.627570721255495	0.401010201996277	0.552569771421889	NA	0.595214753194182	0.464358965274349	0.569496764672921	0.619394432824928	p.Asp109Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.194	-5.703	3.509	0.839	NA	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D109X	109	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D109Y	109	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp109Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45	98.5	42.7	0.781	108	56.3	-66	-26.6	25.668449197861	-3.6	1	0	43.65	0	0	0	0	9	22.9837794511695	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.194	-2.879	0.685	9.687	9.687	21.84	0.003247972	0	0.092832459	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Q110A	110	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.53	-2.36	-0.17	10.422	10.422	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.86	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q110C	110	Q	C	missense	possibly_wt-like	0.826964608966108	0.237837036698363	4	0.118918518349182	0.593888595906846	1.06004062202537	NA	0.886562506555255	0.891697079998451	1.04249363200636	0.487105217304364	NA	NA	NA	0.724150363276793	NA	0.716913918483008	0.731386808070578	0.752884469764392	0.562081429862939	NA	NA	NA	p.Gln110Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.53	-5.454	2.924	1.393	NA	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q110D	110	Q	D	missense	wt-like	1.00250395293723	0.235876795281949	4	0.117938397640974	0.771348941166559	1.23365896470791	1.17325647735186	NA	NA	NA	1.22728537570175	NA	0.8718448155439	0.737629143151421	0.797861923911822	0.865320597698265	NA	NA	NA	0.838566718278517	NA	0.757157129545127	0.66464234676565	p.Gln110Asp	0	0	NA	NA	NA	NA	NA	NA	NA	1.616	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.53	-2.425	-0.105	18.802	18.802	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.21	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q110E	110	Q	E	missense	wt-like	1.10181419164779	0.147885474725188	7	0.0558954555202252	0.992261111928693	1.2113672713669	NA	1.19395401298094	1.05804524543654	1.35605546057695	1.0253842618958	1.17382789137344	0.971272675203683	0.934159794067204	0.812972675414565	NA	0.858616229681764	0.812972675414565	0.890397492947573	0.763149014833277	0.869889448601196	0.8107083178269	0.763349484322291	p.Gln110Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.53	-2.174	-0.356	16.29	16.29	58.31	0.003597121	0	0.102811703	4.066e-06	1	245934	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Dec 14, 2012)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	-0.5	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Q110F	110	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.53	-4.638	2.108	4.809	NA	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.755	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q110G	110	Q	G	missense	wt-like	0.850675935275236	0.169342349955235	8	0.0598715619977059	0.733329830061576	0.968022040488897	0.599338380999857	0.926680243589397	0.767095566352255	0.618621551849091	1.05374879871867	0.920537066121544	0.982791697919242	0.936594176651835	0.740228419151539	0.59226384370539	0.735407520091926	0.670275688892159	0.566994715736991	0.773744242299555	0.745049318211152	0.816912387354029	0.764572148245333	p.Gln110Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.53	-3.036	0.506	20.242	20.242	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.41	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q110H	110	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.53	-3.857	1.327	11.333	11.333	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.755	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Q110I	110	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.53	-4.274	1.744	10.109	NA	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.305	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q110K	110	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.53	-2.569	0.039	25.095	25.095	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	0.86	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
Q110L	110	Q	L	missense	wt-like	1.06370527624072	0.157652972380065	4	0.0788264861900326	0.909208202280407	1.21820235020102	1.13052727866768	1.22776900533093	1.03916670460611	NA	NA	NA	NA	0.85735811635814	0.824352348436819	0.844991048294649	0.874204372063699	0.803713648578989	NA	NA	NA	NA	0.724775990921213	p.Gln110Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.53	-2.868	0.338	32.986	32.986	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.605	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
Q110M	110	Q	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.53	-3.535	1.005	5.989	5.989	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.755	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q110N	110	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.53	-2.733	0.203	27.114	27.114	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.17	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q110P	110	Q	P	missense	low	0.259256281005651	0.177808694560399	4	0.0889043472801997	0.0850069622674179	0.433505599743884	0.150101435208477	0.370395739265354	0.0704088887409733	0.446119060807799	NA	NA	NA	NA	0.428748589557535	0.378527453493655	0.478969725621415	0.328583992381865	0.491343482428862	NA	NA	NA	NA	p.Gln110Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.53	-4.314	1.784	2.456	NA	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.305	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Q110R	110	Q	R	missense	possibly_low	0.695880884328799	0.494777031127686	6	0.201991877118663	0.299984080006579	1.09177768865102	0.65241579861551	0.774368895973808	1.11487000010596	0.910312949793185	-0.259239799858354	NA	NA	0.982557461342681	0.680055490018008	0.617516832688621	0.665194552173947	0.840842516263752	0.694916427862069	0.28329333349657	NA	NA	0.787657118673068	p.Gln110Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.53	-3.104	0.574	31.245	31.245	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
Q110S	110	Q	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.53	-2.337	-0.193	9.113	9.113	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.15	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q110T	110	Q	T	missense	possibly_wt-like	0.975204922879565	0.429519624333464	5	0.19208701553596	0.598721290531298	1.35168855522783	NA	0.507244135958394	0.767490503906429	1.03245844412977	1.65945922740996	NA	NA	0.909372302993278	0.748483522654814	NA	0.542054533398744	0.670469386988072	0.748483522654814	1	NA	NA	0.750900015093359	p.Gln110Thr	0	0	NA	NA	NA	NA	NA	NA	NA	0.273	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.53	-2.872	0.342	9.336	9.336	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.83	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q110V	110	Q	V	missense	possibly_wt-like	0.831025538692002	0.198693107212765	6	0.0811161213465645	0.672040862287155	0.990010215096849	NA	0.88591109911764	0.673492330746923	NA	0.785550252692998	1.10451069203062	0.974312440992743	0.562376416571093	0.695087785331654	NA	0.716613630617167	0.624367751507021	NA	0.673561940046142	0.835724894098977	0.812345515596815	0.576622005362752	p.Gln110Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.53	-3.281	0.751	8.418	7.95	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.96	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q110W	110	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.53	-5.795	3.265	0.914	NA	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q110X	110	Q	X	nonsense	low	-0.0124152058320438	0.155587682511759	6	0.06351840540266	-0.136908992776672	0.112078581112584	NA	0.158887319167197	-0.0230642054844325	-0.0086894060920984	-0.30126254754408	NA	0.0359107741683771	0.063726830792774	0.299407553143036	NA	0.381467903549595	0.282739883156963	0.291886528316119	0.267596247615398	NA	0.306928577969953	0.326176219798879	p.Gln110Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q110Y	110	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln110Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	99.9	42.6	0.979	111.7	40.1	-66.2	-56.9	46.2616822429907	-3.6	1	0	52.4	0	0	0	0	8	25.2662671928403	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.53	-3.554	1.024	10.554	10.554	58.31	0.003597121	0	0.102811703	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.755	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
W111A	111	W	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-1.292	-3.187	1.895	6.325	6.325	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
W111C	111	W	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-1.292	-5.204	3.912	1.412	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	3.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W111D	111	W	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-1.292	-4.347	3.055	1.369	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111E	111	W	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-1.292	-4.157	2.865	1.804	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111F	111	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-1.292	-1.743	0.451	13.964	13.964	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
W111G	111	W	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-1.292	-3.817	2.525	1.879	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W111H	111	W	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-1.292	-3.382	2.09	11.86	11.86	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111I	111	W	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-1.292	-3.358	2.066	10.252	6.67	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
W111K	111	W	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-1.292	-4.183	2.891	2.219	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111L	111	W	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-1.292	-3.052	1.76	33.452	33.452	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
W111M	111	W	M	missense	low	0.399702652722651	0.133735091232308	4	0.0668675456161539	0.2686446715804	0.530760633864902	NA	0.405134493779926	0.219989573485726	0.431426879183869	NA	NA	NA	0.542259664441084	0.489941955174358	NA	0.494983706814715	0.401946207532652	0.484900203534	NA	NA	NA	0.566518405692996	p.Trp111Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-1.292	-4.747	3.455	4.44	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111N	111	W	N	missense	low	0.247819817710795	0.464185947830262	7	0.175445797149954	-0.0960476259420339	0.591687261363624	NA	0.119075127290818	0.0923931619345013	1.29765790948145	0.0161012783519948	0.0899443784631322	0.0426748606302036	0.07689200782347	0.339366233302271	NA	0.363115153116216	0.339366233302271	0.864787156911949	0.386143641705958	0.335672865964312	0.310571670247218	0.332788404382155	p.Trp111Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-1.292	-4.462	3.17	1.828	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111P	111	W	P	missense	low	0.131891327935185	0.143200266213909	3	0.0826767122466263	-0.0301520504283838	0.293934706298754	NA	-0.0194201326079106	NA	0.265296064042078	NA	NA	NA	0.149798052371388	0.369405323597396	NA	0.299271169117046	NA	0.412043278511666	NA	NA	NA	0.369405323597396	p.Trp111Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-1.292	-4.589	3.297	1.274	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111Q	111	W	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-1.292	-4.471	3.179	1.457	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.335	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111R	111	W	R	missense	low	0.0902285899380708	0.0669107654233833	2	0.0473130559652567	-0.00250329575236037	0.182960475628502	0.042915533972814	NA	NA	NA	NA	NA	NA	0.137541645903327	0.345390242898178	0.327530918532924	NA	NA	NA	NA	NA	NA	0.363249567263431	p.Trp111Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-1.292	-4.419	3.127	2.179	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Jul 25, 2012)	criteria provided, single submitter	0	1	0	0	0	2	0	0	0	0	0	0	0	0.000392517663294848	0.000325978971769186	0.000325978971769186	0.000382466767223554	0.000361072281512583	0.000456052849407658	0.000203218398813205	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W111S	111	W	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-1.292	-4.025	2.733	2.187	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W111T	111	W	T	missense	low	0.114573697178337	0.224551725611127	7	0.0848725746339221	-0.0517734923793376	0.280920886736012	NA	-0.0521437808031551	0.38888981543812	0.197042081538175	-0.244197553458355	0.154635858975947	0.014426491012567	0.343362967545062	0.367557529983679	NA	0.284186118023606	0.484783747087145	0.382110389291094	0.288912181539358	0.367557529983679	0.295357285011295	0.466622926140089	p.Trp111Thr	0	0	NA	NA	NA	NA	NA	NA	NA	4.276	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-1.292	-3.979	2.687	2.994	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111V	111	W	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-1.292	-3.783	2.491	8.537	NA	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W111X	111	W	X	nonsense	low	-0.0813519371279471	0.0207163524575233	3	0.0119605916679783	-0.104794266030974	-0.0579096082249199	-0.0783454190562792	-0.103407273819285	-0.0623031185082766	NA	NA	NA	NA	NA	0.263495061645078	0.269837804427146	0.260554510485149	0.263495061645078	NA	NA	NA	NA	NA	p.Trp111Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	1	1	0	0.00234510552974884	0.00278893120291415	0.00278893120291415	0.00122867448970567	0.00285247102394941	0.00326881811136125	0.00506884749039793	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W111Y	111	W	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp111Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.8	102.3	39.8	0.841	115.5	50.4	-61.2	-40.2	7.1969696969697	-3.9	0	0	48.34	1	8	0	0	10	24.362438257695	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-1.292	-2.069	0.777	12.444	12.444	89.08	0.002561676	0	0.073216965	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L112A	112	L	A	missense	low	0.281597277601548	0.0790134563298454	6	0.0322571084703005	0.218374506754357	0.344820048448738	0.281587155329626	0.254634355555067	0.387517869170441	0.362235649370756	0.205871297537347	NA	NA	0.197737338646049	0.447820777377062	0.441085271692641	0.425605675944007	0.484110872661971	0.454556283061483	0.457029922419961	NA	NA	0.393482736981163	p.Leu112Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.26	-3.47	2.21	2.328	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112C	112	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.26	-5.073	3.813	0.625	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112D	112	L	D	missense	low	0.0838003680505958	0.0936773201895807	5	0.0418937711787832	0.00169008536361866	0.165910650737573	0.149695395725621	0.0751145174194783	0.0710156982388341	NA	NA	-0.0599313210367655	NA	0.183107549905811	0.342850051803205	0.378334269441982	0.342850051803205	0.328881603594259	NA	NA	0.261803226788636	NA	0.386134954012561	p.Leu112Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.26	-4.311	3.051	1.265	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112E	112	L	E	missense	low	0.17450842837844	0.13847407456127	4	0.069237037280635	0.0388063289121384	0.310210527844742	NA	0.0706333362116365	0.21149289365138	0.354804251782754	NA	NA	NA	0.0611032318679903	0.36928164633446	NA	0.340784302682693	0.397778989986227	0.451297232195946	NA	NA	NA	0.324858522336649	p.Leu112Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.26	-4.095	2.835	2.717	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112F	112	L	F	missense	possibly_low	0.578112277786255	0.172655384854079	6	0.0704862657060583	0.43996173559766	0.71626281997485	0.499621038395272	0.414053675401065	0.836727669612497	0.73967823615636	NA	NA	0.429249234992366	0.549343812159972	0.557448539345558	0.544820673571051	0.499095299436167	0.704426925393695	0.6200843112133	NA	NA	0.518778074138561	0.570076405120065	p.Leu112Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.26	-2.999	1.739	11.478	11.478	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L112G	112	L	G	missense	low	0.189807951968479	0.143472281177646	8	0.0507251114665083	0.0903885603823427	0.289227343554615	0.251793674266589	0.298432710089019	0.267748333398683	0.306015821756085	-0.102282807810346	0.286097079712542	0.103371145569756	0.107287658765501	0.426139920958889	0.42691023298776	0.445795980277169	0.425369608930018	0.429900991014702	0.341922707336035	0.432351175476642	0.343262288288519	0.348054561007995	p.Leu112Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.26	-4.049	2.789	1.204	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112H	112	L	H	missense	low	0.196853072950676	0.158693923499005	3	0.0916219794509086	0.0172772930346259	0.376428852866725	NA	0.0465506470881945	0.181226276758571	0.362782295005262	NA	NA	NA	NA	0.382934653204605	NA	0.329682588297823	0.382934653204605	0.454796015346989	NA	NA	NA	NA	p.Leu112His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.26	-3.506	2.246	10.718	10.718	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112I	112	L	I	missense	low	0.578993199705311	0.0901611595188058	7	0.0340777151434263	0.512202105348781	0.645784294061842	NA	0.57950740702138	0.560726529793572	0.442233460793803	0.616196156336768	0.497367802169893	0.647615871390104	0.709305170431661	0.575366685199798	NA	0.575366685199798	0.569061486762296	0.489639446554212	0.610301778794597	0.536480744768957	0.636388901729599	0.650416686501603	p.Leu112Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.26	-2.35	1.09	9.163	9.163	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.745	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
L112K	112	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.26	-4.006	2.746	2.378	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112L	112	L	L	synonymous	possibly_wt-like	0.827506559797793	0.324444030935644	8	0.114708287195046	0.602682448167226	1.05233067142836	0.948571735925962	0.847555083244858	1.19313839873388	1.20379921064437	0.368259591845965	0.389519592854936	0.686846415525353	0.982362449607013	0.728676513198216	0.758420873581786	0.698932152814646	0.879229445093815	0.823625279881308	0.517688093107005	0.483325307733989	0.657518213600253	0.787559174407743	p.Leu112=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L112M	112	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.26	-2.051	0.791	5.305	5.305	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L112N	112	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.26	-4.33	3.07	1.652	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112P	112	L	P	missense	low	0.0804188827847682	0.107496256852601	7	0.0406297660717579	0.000786004583835237	0.160051760985701	-0.00772981920195861	0.144331092337051	0.192954515333874	0.219930953116712	-0.055965096746658	NA	-0.00113996751200864	0.0705505021663659	0.359224124507121	0.303435048703016	0.374757727955776	0.388686796692712	0.39214833919834	0.359224124507121	NA	0.286973293299291	0.329603395487637	p.Leu112Pro	1	0	NA	NA	NA	NA	NA	NA	NA	14.91	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.26	-4.39	3.13	0.744	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	Lhermitte-Duclos disease|not provided	Pathogenic(Last reviewed: Aug 5, 2016)	criteria provided, single submitter	1	0	0	0	0	4	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
L112Q	112	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.26	-3.576	2.316	5.627	5.627	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L112R	112	L	R	missense	low	0.113027107957011	0.205860966757968	6	0.0840423877521785	-0.0516929452120085	0.277747161126032	0.0565752190953345	0.220896422441704	0.198298631304846	0.334891743664774	-0.261564299291724	NA	NA	0.129064930527135	0.375149992482983	0.334029875969235	0.410053056573282	0.391307831529678	0.442564571071517	0.282425045027923	NA	NA	0.358992153436288	p.Leu112Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.26	-4.255	2.995	1.909	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L112S	112	L	S	missense	low	0.141238217537745	0.185497983213486	7	0.0701116474695596	0.0038219136006391	0.27865452147485	0.0521955991404875	0.349660023291983	0.249552344173633	0.279702216206835	-0.204438605423919	NA	0.0836569041828279	0.178339041192366	0.383739979776609	0.33194615563319	0.469410909530646	0.416445341209975	0.418361118746376	0.303763652616619	NA	0.332644328131717	0.383739979776609	p.Leu112Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.26	-3.879	2.619	2.59	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112T	112	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu112Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.26	-2.919	1.659	6.895	6.895	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112V	112	L	V	missense	low	0.433234323783797	0.120015684663741	7	0.0453616650067724	0.344327094091753	0.522141553475842	NA	0.364744228726222	0.507496923057032	0.608674184526498	0.395857673707784	0.235616545761737	0.418044715128339	0.502205995578969	0.527997020652162	NA	0.476364474375305	0.542954895069247	0.56263228246672	0.527997020652162	0.407470698916504	0.512743393769312	0.546401528332655	p.Leu112Val	1	0	NA	NA	NA	NA	NA	NA	NA	6.539	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.26	-2.673	1.413	9.019	9.019	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	2	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.095	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L112W	112	L	W	missense	low	-0.124902720151379	0.259192365609596	2	0.183276679354329	-0.484118410891958	0.234312970589201	NA	NA	NA	NA	-0.308179399505707	NA	NA	0.05837395920295	0.294250146101691	NA	NA	NA	NA	0.265012541759679	NA	NA	0.323487750443703	p.Leu112Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.26	-5.349	4.089	0.723	NA	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L112X	112	L	X	nonsense	low	-0.0224174373215642	0.0526003011393948	5	0.0235235697969293	-0.0685227869113598	0.0236879122682315	NA	-0.0971366322746168	-0.0481082415808803	NA	-0.019363095374342	NA	0.0324166968753226	0.0201040857466958	0.304266780859979	NA	0.263445170705109	0.270456973986659	NA	0.372896356586299	NA	0.305046691025674	0.304266780859979	p.Leu112Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L112Y	112	L	Y	missense	low	0.0845430865877308	0.0465925952922668	3	0.0269002474342336	0.0318195704414171	0.137266602734045	NA	0.0309248771695298	0.10752000521596	0.115184377377703	NA	NA	NA	NA	0.346211566971888	NA	0.322479371340135	0.346785230837015	0.346211566971888	NA	NA	NA	NA	p.Leu112Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.4	103.4	41.1	0.726	93.2	75.1	-73.6	-22.2	7.85340314136126	-3.5	0	0	53.77	0	0	0	0	7	24.3370577075373	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.26	-3.057	1.797	8.348	8.348	28.04	0.002244906	0	0.064163164	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.26	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S113A	113	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.266	-2.313	0.047	15.885	15.885	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S113C	113	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.266	-3.604	1.338	21.826	21.826	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S113D	113	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.266	-2.384	0.118	12.01	12.01	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.425	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S113E	113	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.266	-2.588	0.322	11.647	11.647	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.2	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S113F	113	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.266	-4.658	2.392	4.334	NA	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S113G	113	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.266	-2.937	0.671	44.407	44.407	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
S113H	113	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.266	-3.528	1.262	11.948	11.948	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S113I	113	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.266	-3.48	1.214	7.142	7.142	87.1	0.003524982	0	0.100749849	0	NA	NA	PTEN hamartoma tumor syndrome	Pathogenic(Last reviewed: Aug 1, 2012)	no assertion criteria provided	1	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S113K	113	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.266	-2.289	0.023	12.169	12.169	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.015	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S113L	113	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.266	-3.364	1.098	19.288	19.288	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.09	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
S113M	113	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.266	-3.237	0.971	5.627	5.627	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.58	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S113N	113	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.266	-2.509	0.243	12.417	12.417	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.82	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S113P	113	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.266	-4.341	2.075	1.602	NA	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S113Q	113	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.266	-3.18	0.914	6.317	6.317	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S113R	113	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.266	-3.271	1.005	28.001	28.001	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	neutral	neutral	low	1.455	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
S113T	113	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.266	-2.718	0.452	10.19	10.19	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.48	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S113V	113	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.266	-3.961	1.695	4.922	NA	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S113W	113	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.266	-5.829	3.563	0.907	NA	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S113X	113	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S113Y	113	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser113Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.8	104	44.6	0.043	120.6	-104.3	-80.9	36.8	46.1538461538462	-1.8	0	0	66.2	2	4	0	0	7	27.6506444384213	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.266	-3.771	1.505	10.475	10.475	87.1	0.003524982	0	0.100749849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.895	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E114A	114	E	A	missense	possibly_low	0.508237678469674	0.579069287317978	4	0.289534643658989	-0.0592397953785817	1.07571515231793	NA	NA	NA	-0.0715811143055837	0.112721659724348	0.858606199086292	NA	1.13320396937364	0.568380147125065	NA	NA	NA	0.264305272749982	0.422235009067654	0.714525285182476	NA	0.863319034620274	p.Glu114Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.022	-2.194	0.172	14.447	14.447	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.305	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E114C	114	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.022	-5.437	3.415	1.069	NA	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E114D	114	E	D	missense	possibly_wt-like	0.722963727743481	0.343747701811332	3	0.198462828174088	0.333983732252309	1.11194372323465	NA	0.334449714388771	NA	NA	0.987613408548432	NA	0.846828060293242	NA	0.743683270455622	NA	0.462399213109056	NA	NA	0.749040172326529	NA	0.743683270455622	NA	p.Glu114Asp	1	0	NA	NA	NA	NA	NA	NA	NA	1.09	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.022	-2.771	0.749	12.01	12.01	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	low	1.73	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E114E	114	E	E	synonymous	wt-like	1.00998542700111	0.209268577937377	6	0.0854335391907379	0.842538767115476	1.17743208688675	NA	0.78934503425815	1.05117847233259	0.777615257191753	1.19037323100147	1.29194126372193	NA	0.959459303500783	0.792830481707462	NA	0.672098299881226	0.809604849637435	0.636721650257157	0.824778635934361	0.928104304153625	NA	0.776056113777489	p.Glu114=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E114F	114	E	F	missense	possibly_wt-like	0.714662541609877	0.201213858166626	3	0.116170875177185	0.486971810210097	0.942353273009658	0.719078794354008	NA	NA	NA	0.913631922062194	NA	NA	0.511276908413431	0.649233520737835	0.649233520737835	NA	NA	NA	0.721405288580322	NA	NA	0.550957376678668	p.Glu114Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.022	-4.699	2.677	2.375	NA	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.075	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E114G	114	E	G	missense	wt-like	0.940457481772768	0.13882753821892	8	0.0490829468450165	0.844256673701442	1.03665828984409	1.05964143897549	0.895779808288473	1.03558357956234	1.09142154218998	1.05396301726224	0.709459693072336	0.840006452083674	0.837804322747604	0.756916729187017	0.81126523024946	0.721162939458898	0.801956296078421	0.774341880183434	0.773824261028958	0.641015045561735	0.740009197345077	0.714955136074015	p.Glu114Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.022	-2.962	0.94	14.296	14.296	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.18	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E114H	114	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.022	-4.04	2.018	8.17	8.17	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E114I	114	E	I	missense	wt-like	0.864034853692661	0.132093099223811	4	0.0660465496119056	0.734585995150188	0.993483712235134	0.92067373728039	0.89702907538814	0.967596419395618	NA	NA	NA	NA	0.670840182706496	0.733443245735138	0.745147660903046	0.72173883056723	0.768611825967502	NA	NA	NA	NA	0.631097721155432	p.Glu114Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.022	-4.311	2.289	7.171	NA	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E114K	114	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.022	-2.396	0.374	21.863	21.863	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.32	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E114L	114	E	L	missense	possibly_wt-like	0.707879707366204	0.275382515264581	6	0.112424441080404	0.487531851866567	0.92822756286584	NA	0.874296765740459	0.673842180672489	1.01600454026415	0.399805836891764	NA	0.366251027613396	0.917077893014961	0.667899477329429	NA	0.711259618394395	0.624539336264463	0.741267637755685	0.529471808950998	NA	0.484847655880448	0.754770132709523	p.Glu114Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.022	-3.055	1.033	15.002	15.002	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.585	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E114M	114	E	M	missense	possibly_low	0.618136032431648	0.534373506478878	6	0.218157070489182	0.190556031300085	1.04571603356321	NA	0.994210356395897	1.01946632004011	1.1290033107124	-0.135516825677694	NA	0.0738873859462606	0.627765647172918	0.688000692486351	NA	0.766537765593706	0.794051546459652	0.79082342269021	0.329508544498764	NA	0.327382530157801	0.609463619378996	p.Glu114Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.022	-3.83	1.808	8.079	8.079	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.585	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E114N	114	E	N	missense	possibly_low	0.628190923752195	0.303898578202175	3	0.17545592593137	0.284303628052581	0.972078219451808	NA	0.973389357054608	NA	NA	0.400975985303383	0.510207428898593	NA	NA	0.542809046133116	NA	0.756939635305608	NA	NA	0.529908903646668	0.542809046133116	NA	NA	p.Glu114Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.022	-3.117	1.095	8.724	8.724	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E114P	114	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.022	-3.68	1.658	13.504	13.504	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
E114Q	114	E	Q	missense	possibly_low	0.510210717303975	0.380100468722544	4	0.190050234361272	0.137719102702485	0.882702331905465	NA	0.51719309834851	0.346712196407499	0.144396761556277	NA	NA	NA	1.03254081290361	0.505369233801048	NA	0.546640837623938	0.464097629978159	0.35902270307572	NA	NA	NA	0.812761159875176	p.Glu114Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.022	-2.179	0.157	10.935	10.935	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	-0.215	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E114R	114	E	R	missense	possibly_wt-like	0.780283942599963	0.122797640466223	8	0.0434155221436868	0.695191082828336	0.86537680237159	0.537963386461685	0.777246727035591	0.893519530569278	0.821193005557217	0.677858378841948	0.861762604794394	0.769615196109454	0.903112711430135	0.684309057910531	0.563063062458992	0.666521183860801	0.732280633440523	0.655832738965143	0.633334951435436	0.716080991354507	0.702096931960261	0.747756147393372	p.Glu114Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.022	-2.798	0.776	16.306	16.306	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E114S	114	E	S	missense	possibly_wt-like	0.871775467511266	0.304861179939168	8	0.107784703827759	0.660521329924542	1.08302960509799	0.352682932012565	0.844288577726408	1.11090166069819	1.14308586507779	0.463569390225783	0.976634227049724	1.12615142716672	0.956889660132948	0.773731796103581	0.474910972828468	0.697426348744488	0.838896234429831	0.796999348611277	0.553289908144753	0.772698076818262	0.894124990332959	0.774765515388899	p.Glu114Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.022	-2.397	0.375	7.367	7.367	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.89	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E114T	114	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.022	-3.169	1.147	7.75	7.75	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.65	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E114V	114	E	V	missense	possibly_wt-like	0.754817418512782	0.160920094500725	8	0.0568938450253213	0.643307531321149	0.866327305704415	0.689356357044099	0.52423712759148	0.770829143705963	0.59515953025819	0.689963710338661	0.992209840621859	0.918575368836419	0.858208269705584	0.654981790881974	0.635092282982504	0.549888016557042	0.672106831098603	0.55670541000848	0.637856750665344	0.780374871377704	0.782325896794487	0.72520297878809	p.Glu114Val	1	0	NA	NA	NA	NA	NA	NA	NA	2.208	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.022	-3.525	1.503	11.758	11.758	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.075	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E114W	114	E	W	missense	possibly_low	0.692738514371175	0.116746502855055	3	0.0674036248503133	0.560629837237112	0.824847191505238	NA	0.564665465029099	0.720337195348441	0.793212882735986	NA	NA	NA	NA	0.643562012978744	NA	0.568524799724694	0.647342930698575	0.643562012978744	NA	NA	NA	NA	p.Glu114Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.022	-5.804	3.782	0.397	NA	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E114X	114	E	X	nonsense	low	-0.0510245249471721	0.0147798844943044	4	0.00738994224715218	-0.0655085455994214	-0.0365405042949229	-0.0687109097685503	-0.057473228884839	-0.0367558772345587	-0.0411580839007405	NA	NA	NA	NA	0.276836054327917	0.274421677716982	0.28172933215021	0.276024769033634	0.2776473396222	NA	NA	NA	NA	p.Glu114Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E114Y	114	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu114Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.3	107.2	43.1	0.847	81.4	138	42.7	45.6	55.1401869158878	-1.6	0	0	78.32	0	0	0	0	8	29.2700720508167	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.022	-4.646	2.624	1.356	NA	78.91	0.003909858	0	0.111750244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.625	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D115A	115	D	A	missense	possibly_low	0.675035931678841	0.294467497596995	8	0.104109982194934	0.470984116145664	0.879087747212018	0.904557573862726	0.82567095710449	0.934533360210784	0.867411687663174	0.0719506787566679	0.534552903091623	0.489561952525683	0.77204834021558	0.679015667424343	0.737479968774818	0.688843938964128	0.752395967177979	0.676102013235247	0.407005505407029	0.554808265487558	0.551262105309137	0.68192932161344	p.Asp115Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.28	-3.109	1.829	6.9	6.9	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D115C	115	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.28	-5.418	4.138	0.877	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115E	115	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.28	-3.004	1.724	9.804	9.804	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	3.105	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
D115F	115	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.28	-4.573	3.293	2.693	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115G	115	D	G	missense	low	0.531137037646581	0.214149437505224	8	0.0757132597236142	0.38274177543617	0.679532299856991	0.776218275316972	0.206798927212181	0.407187018199578	0.444581968616612	0.461954735889492	0.437978004986519	0.664342119471071	0.850035251480221	0.529947954672614	0.676419144079838	0.4035543485271	0.493757655235341	0.49066938827944	0.552686773671617	0.507209135673612	0.645397548433816	0.721098096264857	p.Asp115Gly	1	0	NA	0.448863520223367	-0.850642357886874	0.359972250612018	0.537754789834715	0.656549311	NA	-0.039	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.28	-2.605	1.325	15.435	15.435	58.31	0.003146767	0	0.089939837	0	NA	NA	Cowden syndrome	Likely pathogenic(Last reviewed: Nov 20, 2015)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.48	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
D115H	115	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.28	-2.293	1.013	30.835	30.835	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.72	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
D115I	115	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.28	-4.379	3.099	1.99	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115K	115	D	K	missense	possibly_low	0.636559697357054	0.320808651771531	7	0.121254273003627	0.398905689298357	0.874213705415751	NA	0.47723018358284	0.659972116774332	0.35853626785049	1.08449106366605	0.777895937889421	0.921917501629788	0.175874810106459	0.617736729272871	NA	0.528218606475195	0.617736729272871	0.452933913594259	0.785227641164134	0.674745401637102	0.78412594743515	0.382502324501798	p.Asp115Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.28	-2.893	1.613	8.044	8.044	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.515	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D115L	115	D	L	missense	low	0.205793107571642	0.218432422335568	6	0.089174663000376	0.0310139797574086	0.380572235385876	NA	0.12264044095222	0.386891135840195	0.399069427900867	-0.189202793156665	NA	0.264414903186062	0.250945530707174	0.425102920082532	NA	0.364758702711465	0.483803489756925	0.470709793404324	0.309454804832963	NA	0.429999392106547	0.420206448058516	p.Asp115Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.28	-4.014	2.734	3.279	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115M	115	D	M	missense	low	0.384003978795893	0.142680418054043	8	0.0504451455742728	0.285133310275439	0.482874647316348	0.685824551937023	0.388036882955697	0.31891955078492	0.402379535218743	0.26178752098252	0.252071635733154	0.296468259488489	0.466543893266601	0.475039096562276	0.63341193304337	0.487101995969995	0.450466658497767	0.472161446070138	0.477916747054415	0.415580963374637	0.447263118030925	0.528490306738958	p.Asp115Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.28	-5.136	3.856	1.271	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D115N	115	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.28	-2.053	0.773	28.293	28.293	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.785	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
D115P	115	D	P	missense	low	0.3416747313369	0.254332744604651	7	0.0961287417834875	0.153265859562114	0.530083603111686	NA	0.260079528725721	0.200494700506061	0.0922888291359942	0.579147059095499	0.163356901515156	0.79902697601944	0.29732912436043	0.428115809135816	NA	0.428115809135816	0.392384899076872	0.336170689003718	0.596462539495792	0.37185589367944	0.717937922292861	0.443502517845947	p.Asp115Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.28	-4.124	2.844	1.721	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115Q	115	D	Q	missense	possibly_low	0.595295125080193	0.167767073200675	4	0.0838835366003376	0.430886414447684	0.759703835712702	NA	0.773510261559084	0.703393849820934	0.453477938280023	NA	NA	NA	0.450798450660732	0.579807606974259	NA	0.664798736159197	0.639033025164421	0.494570729485856	NA	NA	NA	0.520582188784097	p.Asp115Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.28	-3.421	2.141	5.415	5.415	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D115R	115	D	R	missense	low	0.461144807012787	0.156278833385365	6	0.0638005665652623	0.336097994351622	0.586191619673951	NA	0.346144844397711	0.579062503132355	0.718802186399441	0.361713907128313	NA	0.327055242307319	0.43409015871158	0.513716756937353	NA	0.467790471219298	0.578054410035607	0.610929087418098	0.515243032257284	NA	0.463737064885532	0.512190481617421	p.Asp115Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.28	-4.037	2.757	4.123	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D115S	115	D	S	missense	wt-like	0.959848534907203	0.134644693351463	8	0.0476040878598012	0.866546237185112	1.05315083262929	0.832956405472958	0.876966753247394	0.881826381117463	1.00883744453264	1.21577573852616	1.04166030381741	0.814569446532436	1.00619580601116	0.732335098188044	0.703413814132055	0.71249043770038	0.726545699499432	0.738124496876656	0.83426743341125	0.804747654193824	0.72630899422032	0.799529431352695	p.Asp115Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.28	-2.682	1.402	9.168	9.168	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.325	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
D115T	115	D	T	missense	possibly_low	0.591879459937417	0.192839895187415	8	0.0681791987851623	0.458250685823702	0.725508234051132	0.618253141100946	0.62590028438843	0.600157154362673	0.69315898121791	0.331073132038624	0.405894209609293	0.498781657079177	0.961817119702286	0.592576677283976	0.60126304242135	0.596753020894342	0.58840033367361	0.599683220264262	0.503797543693673	0.491395909141158	0.55622777726603	0.777240322383376	p.Asp115Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.28	-3.766	2.486	4.474	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.8	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D115V	115	D	V	missense	low	0.239621328720006	0.157877014038246	8	0.0558179536099638	0.13022014995375	0.349022507486263	0.109801226968896	0.306393273186708	0.426366183124636	0.473424100338159	0.0515658957565301	0.249717379647792	0.0722534909285573	0.227449079808772	0.41141300804707	0.359353560708111	0.449465665892437	0.503164123898361	0.503318149597607	0.399391017848641	0.414420614844934	0.326502525096593	0.408405401249206	p.Asp115Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.28	-4.074	2.794	2.404	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D115W	115	D	W	missense	low	-0.120022288302585	0.261089909697277	2	0.184618445646328	-0.481867792651154	0.241823216045983	NA	NA	NA	NA	-0.304640733948914	NA	0.0645961573437427	NA	0.294356351512555	NA	NA	NA	NA	0.266334367204439	NA	0.322378335820671	NA	p.Asp115Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.28	-5.765	4.485	0.504	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D115X	115	D	X	nonsense	low	0.002836505551117	0.16582943296285	4	0.0829147164814251	-0.159673352540826	0.16534636364306	-0.0367536799362795	-0.11830734837943	NA	NA	NA	-0.0801018185968482	NA	0.246508869117025	0.271656002076791	0.289626177278976	0.253685826874606	NA	NA	NA	0.251861739397892	NA	0.41797814339545	p.Asp115Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D115Y	115	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp115Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.7	105.6	43	0.742	96.9	-17	-84.6	-25.8	31.0160427807487	-1.5	0	0	87.92	1	1	0	0	5	29.7961453523774	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.28	-4.421	3.141	5.055	NA	58.31	0.003146767	0	0.089939837	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.8	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D116A	116	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.574	-2.743	0.169	12.003	12.003	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D116C	116	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.574	-3.984	1.41	20.507	20.507	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D116E	116	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.574	-2.34	-0.234	26.684	26.684	90.82	0.003669492	0	0.104880206	4.066e-06	1	245950	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	-0.635	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D116F	116	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.574	-4.711	2.137	1.703	NA	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D116G	116	D	G	missense	wt-like	0.997870348971538	0.0780398582979716	8	0.0275912565026665	0.943792479938105	1.05194821800497	1.11616097876212	1.0189836906207	0.944474943572563	1.01361667642192	0.94099029266344	1.09448530720731	0.962583890878741	0.891667011645518	0.767614848482159	0.838155900136685	0.777957855747049	0.75727184121727	0.740220436387484	0.731624674901949	0.830783655712992	0.806028595997255	0.742007566915936	p.Asp116Gly	1	0	NA	NA	NA	NA	NA	NA	NA	0.057	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.574	-3.061	0.487	46.305	46.305	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.245	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
D116H	116	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.574	-4.152	1.578	13.353	13.353	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.24	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D116I	116	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.574	-2.931	0.357	10.309	10.309	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D116K	116	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.574	-2.508	-0.066	13.819	13.819	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.75	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D116L	116	D	L	missense	possibly_wt-like	0.708904337209125	0.517594813877215	8	0.182997401399784	0.35023602120113	1.06757265321712	1.04747207247431	0.439093691139958	0.142967417644025	0.0232011017044455	1.46623987686313	0.943203808086118	1.15856935703564	0.450487372725373	0.638323543395946	0.805475331418799	0.510638325279375	0.364170501545756	0.305872159660154	0.927825263542488	0.756221136296393	0.911585073171474	0.520425950495498	p.Asp116Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.574	-2.85	0.276	11.368	11.368	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D116M	116	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.574	-4.159	1.585	3.095	3.095	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D116N	116	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.574	-3.223	0.649	18.547	18.547	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D116P	116	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.574	-2	-0.574	22.588	22.588	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	-1.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D116Q	116	D	Q	missense	possibly_wt-like	1.06368147329295	0.645789110717055	3	0.372846516912221	0.33291572838379	1.7944472182021	NA	NA	NA	NA	1.65945922740996	NA	1.15416126939847	0.377423923070408	0.909210906294822	NA	NA	NA	NA	1	NA	0.909210906294822	0.483729974871086	p.Asp116Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.574	-3.154	0.58	8.653	8.653	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D116R	116	D	R	missense	wt-like	1.02473031628636	0.166585989466304	5	0.0744995193091439	0.878713941574895	1.17074669099783	0.815854293364054	1.14280642716625	1.15154614304139	1.14218744605891	NA	NA	NA	0.871257271801207	0.796605345565897	0.695277030767734	0.835038053412503	0.858830420875376	0.796605345565897	NA	NA	NA	0.731756814735957	p.Asp116Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.574	-3.266	0.692	10.159	10.159	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.985	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D116S	116	D	S	missense	wt-like	0.997795283743758	0.120639767204203	7	0.0455975460352925	0.908425735731178	1.08716483175634	1.04753917006377	1.02484923344075	0.997017814524211	0.899286007040917	0.79064852228202	1.16329159880947	NA	1.06193464004518	0.783041621653645	0.805507254876335	0.780661772272594	0.783041621653645	0.690080545123266	0.675466336593048	0.864696397742742	NA	0.827524152443809	p.Asp116Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.574	-2.495	-0.079	10.423	10.423	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.1	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D116T	116	D	T	missense	possibly_low	0.59468151954145	0.817576631908677	3	0.472028088515622	-0.330476533640454	1.51983957272335	NA	1.10392387139302	1.02849023790676	NA	-0.348369550675429	NA	NA	NA	0.798477349197258	NA	0.817113849577309	0.798477349197258	NA	0.25	NA	NA	NA	p.Asp116Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.574	-3.124	0.55	11.106	11.106	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D116V	116	D	V	missense	wt-like	1.09927986266874	0.088675418232586	2	0.0627029895568147	0.97638426141439	1.22217546392309	1.16198285222555	NA	NA	NA	NA	NA	NA	1.03657687311192	0.837372567426669	0.859956871580743	NA	NA	NA	NA	NA	NA	0.814788263272596	p.Asp116Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.574	-3.124	0.55	10.021	10.021	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.24	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
D116W	116	D	W	missense	possibly_wt-like	0.805695666878734	0.127171391444344	6	0.0519175031530644	0.703939230531483	0.907452103225985	0.866177294358492	0.738573585770303	0.684416725497345	0.911380309975931	0.664211608587253	NA	NA	0.96941447708308	0.672039018452325	0.719219532999435	0.648693516589415	0.629725647811883	0.695384520315235	0.628237366520461	NA	NA	0.781056080365954	p.Asp116Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.574	-5.897	3.323	0.499	NA	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D116X	116	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D116Y	116	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp116Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	51.1	107.1	39.5	0.414	131.5	-27.4	-141.7	-47.8	55.0802139037433	-1.5	0	0	91.05	1	1	0	0	5	29.024959911428	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.574	-4.723	2.149	2.189	NA	90.82	0.003669492	0	0.104880206	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N117A	117	N	A	missense	wt-like	1.08928545262439	0.0910746491246009	8	0.0321997509950954	1.02617510036285	1.15239580488594	1.20440857398686	1.09388290914194	0.990253623120342	1.08815311145186	1.00956043996256	1.22375042253934	1.1145159774931	0.989758563299151	0.801879496551621	0.880142033790442	0.812485134964525	0.779724107323914	0.772908504845905	0.75723821876368	0.89449490082772	0.887858214015465	0.791273858138716	p.Asn117Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.607	-2.758	0.151	15.813	15.813	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.575	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N117C	117	N	C	missense	wt-like	0.93475824553961	0.128796433703385	4	0.0643982168516924	0.808540059841693	1.06097643123753	NA	1.11564881987743	0.93684670727366	NA	0.831038874140815	NA	0.855498580866535	NA	0.75094185474525	NA	0.82251885350291	0.753530553941202	NA	0.690553660883212	NA	0.748353155549298	NA	p.Asn117Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.607	-4.293	1.686	21.826	21.826	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N117D	117	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.607	-2.411	-0.196	21.756	21.756	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N117E	117	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.607	-2.101	-0.506	12.015	12.015	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N117F	117	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.607	-4.681	2.074	3.324	NA	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N117G	117	N	G	missense	wt-like	0.900140392713404	0.175218928496758	8	0.0619492462661492	0.778722101162349	1.02155868426446	0.737036773607009	1.01379874527887	0.988085775718977	1.19959155965801	0.783472729560468	0.746332912550041	0.727764832149051	1.0050398131848	0.727562142823016	0.657777505592581	0.77556768320481	0.778660881227948	0.821780008056381	0.672785906568385	0.659188848434064	0.679556602441222	0.79894883620179	p.Asn117Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.607	-3.159	0.552	13.79	13.79	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.69	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N117H	117	N	H	missense	possibly_wt-like	0.998092701979364	0.300115240399146	3	0.173271614832356	0.65848657736485	1.33769882659388	NA	1.1512253767921	1.19075107638148	NA	NA	NA	NA	0.652301652764515	0.838919047502808	NA	0.838919047502808	0.878058576967693	NA	NA	NA	NA	0.621786780513073	p.Asn117His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.607	-3.639	1.032	29.43	29.43	49.88	0.003580665	0	0.10234137	1.219e-05	3	246010	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 11, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
N117I	117	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.607	-3.613	1.006	7.614	7.614	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	low	1.545	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N117K	117	N	K	missense	wt-like	0.965179139815551	0.278410577362736	5	0.124508995327608	0.721145993222173	1.20921228640893	NA	NA	1.22616635266363	0.572585595303997	1.15026473537586	0.777009819813688	1.09986919592057	NA	0.809796595609244	NA	NA	0.895428086424541	0.546805576043222	0.809796595609244	0.674308658237472	0.879969554233426	NA	p.Asn117Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.607	-2.223	-0.384	12.169	12.169	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.615	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N117L	117	N	L	missense	wt-like	0.974151360915438	0.0787309271316224	8	0.0278355862319371	0.919594614412282	1.02870810741859	0.84935852616698	1.0997057501887	0.953763670826334	0.92938311514433	0.983331011916917	1.06656471825494	0.968132561497685	0.942971533327619	0.76480134180758	0.711217558017771	0.815169366691236	0.761827520370839	0.703279678267878	0.747440535191783	0.817022359930116	0.809017073331932	0.767775163244322	p.Asn117Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.607	-2.804	0.197	15.654	15.654	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.535	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N117M	117	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.607	-3.902	1.295	3.497	3.497	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.195	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N117P	117	N	P	missense	low	0.175007534280666	0.225034698547621	6	0.0918700309771169	-0.00505441769306206	0.355069486254394	NA	0.444348918181942	0.331578114140494	NA	-0.215519652291757	0.169054638986878	0.120517783218352	0.200065403448087	0.384658077939212	NA	0.513060896502576	0.456675082065129	NA	0.299624462441845	0.374664152873947	0.352497354036301	0.394652003004476	p.Asn117Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.607	-4.325	1.718	2.067	NA	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.545	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N117Q	117	N	Q	missense	low	0.0435480297296457	0.0926472511718716	4	0.0463236255859358	-0.0472446080521065	0.134340667511398	NA	-0.0109795797994244	0.179917346401614	NA	-0.0177646874710225	0.023019039787416	NA	NA	0.338327772156567	NA	0.303162121910977	0.382292685088011	NA	0.373493422402157	0.302687194263154	NA	NA	p.Asn117Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.607	-2.584	-0.023	17.89	17.89	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.325	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N117R	117	N	R	missense	wt-like	1.10902742098947	0.112171742061562	8	0.0396586997346193	1.03129779783593	1.18675704414302	1.19960804543945	0.978486291801437	0.979552165719115	1.11116956875258	1.28984501699847	1.1209510529423	1.17662255536104	1.0159846709014	0.824136884364769	0.877858055029471	0.759289236444733	0.774475551190911	0.78300240766825	0.861935110785213	0.84382789900582	0.921308406510035	0.804445869723718	p.Asn117Arg	0	0	NA	NA	NA	NA	NA	NA	NA	1.902	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.607	-2.557	-0.05	17.586	17.586	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.225	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N117S	117	N	S	missense	wt-like	1.13021245791319	0.118318445792028	8	0.041831887679498	1.04822346465605	1.21220145117033	0.963967922091174	1.32282428164002	1.0810573792681	1.04315790295409	1.08310248015665	1.19708426127636	1.25435728969012	1.09614814622903	0.834483426281228	0.765746017439184	0.91802325470381	0.824259033115827	0.753175786812296	0.784708952696566	0.881351878194504	0.963175820817593	0.844707819446628	p.Asn117Ser	1	0	NA	NA	NA	NA	NA	NA	NA	-1.302	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.607	-2.649	0.042	12.879	12.879	49.88	0.003580665	0	0.10234137	8.129e-06	2	246018	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Oct 14, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.075	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N117T	117	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.607	-3.126	0.519	7.139	7.139	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
N117V	117	N	V	missense	possibly_wt-like	0.716409046872119	0.174888251705399	8	0.0618323343653736	0.595219898435948	0.837598195308289	0.593084112866253	0.524287682966507	0.654824234202416	0.739594865140425	0.869231479150684	1.06715358127316	0.647321460411954	0.635774958965546	0.617629843157717	0.589288209784769	0.549911321734104	0.615211937589664	0.62004774872577	0.704820043589767	0.81731259442994	0.636230333921974	0.613486280664476	p.Asn117Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.607	-3.993	1.386	4.943	NA	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.89	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N117W	117	N	W	missense	low	0.529273188676092	0.187349545779711	8	0.0662380671365267	0.399448962682954	0.659097414669231	0.497598526344361	0.452770556239244	0.499962430408171	0.574529823403289	0.857251283940305	0.18327895074367	0.620291534074156	0.548502404255542	0.54575831505037	0.543858409828118	0.516943129914538	0.53925958459717	0.547658220272623	0.700344987496412	0.381674927672682	0.621672194186182	0.56965380963495	p.Asn117Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.607	-5.828	3.221	0.696	NA	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N117X	117	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn117Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N117Y	117	N	Y	missense	wt-like	0.855518968817132	0.127029608624272	3	0.0733405787342764	0.711774075892626	0.999263861741638	0.770541040864888	NA	NA	NA	1.00154819205478	NA	NA	0.794467673531732	0.693189388209942	0.673718049235475	NA	NA	NA	0.754245341085851	NA	NA	0.693189388209942	p.Asn117Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	108.1	38.4	0.692	54.3	-113.1	-153.3	-154.8	18.1818181818182	-2.1	0	0	83.56	1	54	0	0	6	27.4184769427479	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.607	-3.955	1.348	8.033	8.033	49.88	0.003580665	0	0.10234137	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	low	1.34	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
H118A	118	H	A	missense	low	0.460268390672793	0.208972969680661	6	0.0853128576252867	0.293058262309038	0.627478519036548	NA	0.30190756318212	0.603713600356634	0.646543522599972	0.666485372386005	0.381452768887772	NA	0.161507516624254	0.529294664774492	NA	0.447397829072843	0.590144601368509	0.579239939043314	0.629086703310369	0.479349390505669	NA	0.375286379266506	p.His118Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.833	-3.037	1.204	6.541	6.541	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118C	118	H	C	missense	low	0.0683590869156723	0.047955930691168	2	0.033909963789837	0.00189677917053442	0.13482139466081	NA	NA	NA	NA	0.102269050705509	NA	0.0344491231258353	NA	0.362235953288761	NA	NA	NA	NA	0.41833056420179	NA	0.306141342375732	NA	p.His118Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.833	-5.371	3.538	0.841	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118D	118	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.833	-3.588	1.755	7.133	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.935	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
H118E	118	H	E	missense	low	0.160069636397374	0.076493515875392	8	0.0270445418961453	0.107063308302544	0.213075964492203	0.0567808687049528	0.148602001232942	0.259130166781327	0.289565390781346	0.124352244388521	0.121228970326073	0.137109508692293	0.143787940271533	0.371556650776183	0.334127719224604	0.376726545079268	0.421142807891724	0.422686629157218	0.426579472397066	0.351092186910836	0.36143354775318	0.366386756473098	p.His118Glu	0	0	NA	NA	NA	NA	NA	NA	NA	2.105	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.833	-3.577	1.744	4.237	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H118F	118	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.833	-4.395	2.562	3.356	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118G	118	H	G	missense	low	0.168195863458785	0.135911636012606	8	0.0480520197333358	0.0740156353970388	0.262376091520531	0.192966091292208	0.175925129330278	0.273383668619471	0.36606579021909	-0.00672599526521033	-0.0453482176988984	0.214838389620083	0.174462051553258	0.394121748821615	0.398921450347286	0.389322047295945	0.428133472965135	0.456235997233558	0.377616791508488	0.268990840159078	0.40329780945748	0.381792769263492	p.His118Gly	0	0	NA	NA	NA	NA	NA	NA	NA	2.335	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.833	-2.922	1.089	12.272	12.272	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118I	118	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.833	-4.303	2.47	1.907	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118K	118	H	K	missense	low	0.312989310387582	0.265053626368883	5	0.118535585248731	0.0806638324136927	0.545314788361472	NA	0.177031140142034	0.44138771276599	0.663180116849254	NA	NA	-0.0382029867061479	0.32155056888678	0.455667691296207	NA	0.38983189966649	0.510531470098998	0.586535943091765	NA	NA	0.26701139604084	0.455667691296207	p.His118Lys	0	0	NA	NA	NA	NA	NA	NA	NA	0.89	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.833	-3.574	1.741	4.679	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118L	118	H	L	missense	low	0.322713939735082	0.331429219871472	8	0.117177924427243	0.0930494280745308	0.552378451395634	-0.0876601116513871	0.420563303614845	0.600016270963487	0.871216628349992	0.101478193849703	0.0504837776871813	0.524860176000394	0.100753279066444	0.460065638869231	0.265406092409999	0.502096128488548	0.588331237063577	0.67777067583765	0.418035149249913	0.316223813511503	0.570273495253307	0.344772681500668	p.His118Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.833	-3.845	2.012	2.625	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H118M	118	H	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.833	-4.987	3.154	1.015	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118N	118	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.833	-1.205	-0.628	27.114	27.114	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-2.045	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
H118P	118	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.833	-3.338	1.505	10.803	10.803	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H118Q	118	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.833	-3.998	2.165	2.935	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.935	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.785714285714286
H118R	118	H	R	missense	possibly_wt-like	0.79095288348797	0.170447315157761	7	0.064423029649441	0.66468606560011	0.91721970137583	NA	0.60771051410064	0.721622373857594	0.767166374381427	0.978828362976015	1.06998905948694	0.650676897919969	0.740676601693208	0.647973249662929	NA	0.588367842917483	0.647973249662929	0.632139276596802	0.745758625487861	0.818710124204551	0.63803755039404	0.666172926896946	p.His118Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.833	-2.379	0.546	9.647	9.647	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.155	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.714285714285714
H118S	118	H	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.833	-3.453	1.62	6.034	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.385	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H118T	118	H	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.833	-3.684	1.851	4.288	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118V	118	H	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.833	-4.019	2.186	2.304	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118W	118	H	W	missense	possibly_low	0.454930569767326	0.332985162242904	4	0.166492581121452	0.128611107076167	0.781250032458485	NA	0.109197523417643	0.283148574253388	0.556071384377654	NA	NA	NA	0.871304797020618	0.48624296918371	NA	0.358561743966399	0.432922694977757	0.539563243389664	NA	NA	NA	0.731780684185063	p.His118Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.833	-5.605	3.772	0.703	NA	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H118X	118	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H118Y	118	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His118Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44	107.2	38.8	0.356	71	72.8	-146.9	16.8	29.6296296296296	-1.5	0	0	66.94	0	0	0	0	6	25.4910105303811	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.833	-3.349	1.516	8.112	8.112	85.61	0.002487253	0	0.071089829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V119A	119	V	A	missense	low	0.41494981888551	0.294315716925082	8	0.104056319623753	0.211003180059166	0.618896457711853	0.309643701004493	0.248959642168554	0.263988368096718	0.511410745307391	1.02559845811678	0.0464620279957389	0.565034837505762	0.348500770888643	0.461818647605764	0.454433917325054	0.422989728575749	0.423525524689376	0.51997725129413	0.763229025224346	0.314241602922642	0.591911302501618	0.469203377886474	p.Val119Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.117	-2.695	1.578	16.963	16.963	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V119C	119	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.117	-3.644	2.527	10.553	10.553	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119D	119	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.117	-4.187	3.07	1.71	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V119E	119	V	E	missense	low	0.187481400520747	0.0673913210105854	4	0.0336956605052927	0.121439119495085	0.25352368154641	NA	0.0982284228052427	0.253828050405486	0.221233090545466	NA	NA	NA	0.176636038326793	0.387802021735476	NA	0.353505173189208	0.418542371859608	0.392719393574583	NA	NA	NA	0.382884649896368	p.Val119Glu	0	0	NA	NA	NA	NA	NA	NA	NA	5.988	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.117	-4.03	2.913	2.358	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119F	119	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.117	-4.12	3.003	2.292	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jun 25, 2013)	criteria provided, single submitter	0	1	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V119G	119	V	G	missense	low	0.20115091456863	0.0664157203426146	8	0.0234815031158261	0.155128014158746	0.247173814978514	0.139671101768261	0.25344997522566	0.228478314539986	0.294707927696454	0.152679858716491	0.248392218777976	0.10020155273444	0.191626367089771	0.409938505363602	0.373564945758924	0.425059696544749	0.406109531484837	0.42494189664705	0.437160907914808	0.413767479242367	0.341555166529272	0.39041351339085	p.Val119Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.117	-3.9	2.783	4.589	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V119H	119	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.117	-5.19	4.073	0.874	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119I	119	V	I	missense	possibly_wt-like	0.822828800785686	0.149929534670124	2	0.106016190665388	0.615040885303394	1.03061671626798	NA	NA	NA	NA	0.716812610120298	NA	NA	0.928844991451074	0.704282982699481	NA	NA	NA	NA	0.647885830363779	NA	NA	0.760680135035184	p.Val119Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.117	-1.605	0.488	13.88	13.88	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	1.945	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V119K	119	V	K	missense	low	0.354598231714038	0.219941893850071	5	0.0983610051497604	0.161814204137349	0.547382259290727	0.676757600323056	0.192523879605214	0.29195448231109	0.471363779886653	NA	NA	NA	0.140391416444175	0.43724157426775	0.629098090367808	0.396973791823043	0.43724157426775	0.50241459288822	NA	NA	NA	0.36468085898037	p.Val119Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.117	-4.033	2.916	2.641	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119L	119	V	L	missense	low	0.411850842182345	0.195428829024662	8	0.0690945251213426	0.276428061415616	0.547273622949075	0.37233883871646	0.619855871441405	0.446420340682672	0.601674308310788	0.362690228796449	-0.0074771248919034	0.49537475564015	0.403929518762742	0.514303730092504	0.484262791695076	0.593966648250568	0.512999734852749	0.559562475964065	0.515607725332259	0.287656467543477	0.554392842660749	0.497042358806277	p.Val119Leu	1	0	NA	NA	NA	NA	NA	NA	NA	3.4	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.117	-2.987	1.87	8.567	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Nov 20, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V119M	119	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.117	-3.514	2.397	3.095	3.095	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119N	119	V	N	missense	low	0.34587735544776	0.401244505417598	7	0.151656168038011	0.0486367280599047	0.643117982835615	1.11239374410201	0.0450582046371925	0.300070233033446	0.625007495621751	0.274723221962194	-0.0217241843291201	NA	0.085612773106847	0.441221964193225	0.836363538344371	0.328994597445059	0.441221964193225	0.569795281220549	0.482748720697111	0.280634481034301	NA	0.337168391800984	p.Val119Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.117	-4.353	3.236	1.538	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119P	119	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.117	-4.239	3.122	1.702	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119Q	119	V	Q	missense	possibly_low	0.415593692346292	0.570358525069429	7	0.215575259354187	-0.00692605194579488	0.83811343663838	0.37248691607099	0.106544822957793	0.206099691409325	0.383689441938612	1.65945922740996	-0.0691302698806736	NA	0.250006016518041	0.419734578882533	0.484333243423336	0.357338893698187	0.395133880666742	0.463964876856842	1	0.257269316126919	NA	0.419734578882533	p.Val119Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.117	-4.465	3.348	1.518	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119R	119	V	R	missense	low	0.158681176779187	0.135432691799692	8	0.0478826873829549	0.0648328340256044	0.252529519532769	0.391321722865348	0.168904422241818	0.198032004330042	0.258675311673147	0.0148804613645533	0.0429883197932804	-0.00521336875942052	0.199860540724725	0.388631341578465	0.493294402233348	0.386085619483568	0.391177063673361	0.409139737356324	0.385687620380547	0.312529507016678	0.284779386300852	0.394549111099723	p.Val119Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.117	-4.394	3.277	1.852	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119S	119	V	S	missense	low	0.093582830590197	0.134621194037801	8	0.0475957795977796	0.000296816762442711	0.186868844417951	0.0473038345584779	0.064105511849152	0.184200713233714	0.306462181031176	-0.152027253323956	0.122542283479187	0.0205998473154619	0.155475526578364	0.344757284304697	0.329618768909281	0.337775085511993	0.384393472897898	0.430096742562725	0.323341275222694	0.351739483097402	0.298682213927979	0.372256823986321	p.Val119Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.117	-3.802	2.685	4.934	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119T	119	V	T	missense	low	0.541069382665787	0.166383345497813	4	0.0831916727489065	0.378016700264288	0.704122065067286	NA	0.299031906481335	0.570189078680482	0.669359052022117	NA	NA	NA	0.625697493479214	0.581474070899342	NA	0.446072199729815	0.573702417163844	0.58924572463484	NA	NA	NA	0.608424893204827	p.Val119Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.117	-2.587	1.47	8.299	8.299	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.605	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119V	119	V	V	synonymous	possibly_wt-like	0.940107117698652	0.310421549819184	5	0.138824737415307	0.668015632201421	1.21219860319588	NA	1.06428665945614	NA	0.398339241241543	1.0936813860628	NA	1.16718358418108	0.977044717551698	0.788660574227351	NA	0.798841761951201	NA	0.470389568919509	0.788660574227351	NA	0.916224638996843	0.784888353815497	p.Val119=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V119W	119	V	W	missense	low	0.307167663755256	0.347552211468886	6	0.141887596179108	0.0290730853912417	0.585262242119269	0.261066026862294	0.845330837636049	0.554462123817823	NA	-0.145192640497266	0.112434687047273	NA	0.214904947665362	0.416713467940621	0.431321800627383	0.697906813022057	0.565989093426425	NA	0.325894261650603	0.346757724854737	NA	0.402105135253858	p.Val119Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.117	-5.602	4.485	0.318	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V119X	119	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V119Y	119	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val119Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	105.7	35.8	0.997	46.6	-167.6	-138.2	141.3	3.03030303030303	-3.4	0	1	52.9	0	0	0	0	6	22.1239937140653	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.117	-4.298	3.181	1.04	NA	58.56	0.002236571	0	0.063924919	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120A	120	A	A	synonymous	wt-like	1.00339611294547	0.093701231917858	3	0.0540984314711748	0.897365135641861	1.10942709024908	NA	NA	NA	NA	0.897733027881811	1.03606816133567	NA	1.07638714961893	0.80199143988608	NA	NA	NA	NA	0.715466450186613	0.80199143988608	NA	0.834782897295505	p.Ala120=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A120C	120	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.607	-3.547	1.94	35.857	35.857	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A120D	120	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.607	-4.23	2.623	1.992	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120E	120	A	E	missense	low	-0.0751924818886593	0.035368804085578	4	0.017684402042789	-0.109853272980652	-0.0405316907966663	-0.0568179954385996	NA	NA	NA	-0.120612558802061	-0.0838791416981843	-0.0394602316157922	NA	0.273207149667622	0.280080047095982	NA	NA	NA	0.335075851969765	0.25	0.266334252239263	NA	p.Ala120Glu	1	0	NA	NA	NA	NA	NA	NA	NA	15.48	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.607	-4.067	2.46	2.024	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Nov 18, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A120F	120	A	F	missense	low	0.449809071726941	0.258547419595294	5	0.115625921124448	0.223186430643755	0.676431712810127	0.0635037805417377	0.593126461886925	0.476108249413887	0.749786901558076	NA	NA	NA	0.366519965234081	0.527560242791544	0.337326322814909	0.581644840290127	0.527560242791544	0.624517482004764	NA	NA	NA	0.478253483234556	p.Ala120Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.607	-4.256	2.649	2.551	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120G	120	A	G	missense	possibly_low	0.587628101188932	0.212489718325434	8	0.0751264603801669	0.44038294455783	0.734873257820035	0.926911036435352	0.594529290727309	0.537675213473509	0.738247832424243	0.447190267822362	0.210800909818508	0.546939000074492	0.698731258735685	0.582228262399455	0.748115221382079	0.582291520776554	0.557755911913063	0.619457005452032	0.547171686343848	0.395239749675513	0.582165004022357	0.645105959897773	p.Ala120Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.607	-3.25	1.643	29.858	29.858	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A120H	120	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.607	-5.223	3.616	0.757	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120I	120	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.607	-1.752	0.145	11.856	9.837	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.88	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A120K	120	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.607	-4.058	2.451	2.125	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120L	120	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.607	-2.558	0.951	10.809	10.809	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120M	120	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.607	-3.478	1.871	3.577	3.577	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A120N	120	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.607	-4.384	2.777	2.258	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120P	120	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.607	-4.284	2.677	1.233	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A120Q	120	A	Q	missense	low	0.108151132976768	0.0986010161399084	4	0.0493005080699542	0.0115239127401317	0.204778353213405	-0.00902804150195499	0.0748553417103041	0.222154289104736	NA	NA	NA	NA	0.144622942593988	0.3547683554651	0.302817385016418	0.342730576163088	0.40300789763825	NA	NA	NA	NA	0.366806134767113	p.Ala120Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.607	-4.489	2.882	1.297	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120R	120	A	R	missense	low	0.139188481413938	0.0726243909247239	8	0.0256765996512075	0.0888632708521178	0.189513691975759	0.151404107596559	0.201626495679528	0.250990621703156	0.161046632049402	0.0932940056399852	0.0742431924210575	0.0240432262391948	0.156859569982623	0.376049595762269	0.379147234427671	0.401169944640288	0.41715074796585	0.36632452944137	0.414978045365218	0.327934180163823	0.300536795065512	0.372951957096867	p.Ala120Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.607	-4.37	2.763	1.566	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120S	120	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.607	-3.264	1.657	8.622	8.622	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.63	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A120T	120	A	T	missense	possibly_low	0.484374764796794	0.810884808883439	4	0.40544240444172	-0.310277745714298	1.27902727530789	NA	NA	NA	NA	1.65945922740996	-0.0838791416981843	-0.0248861610093042	0.386805134484708	0.381312710225653	NA	NA	NA	NA	1	0.25	0.274183750375403	0.488441670075902	p.Ala120Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.607	-3.059	1.452	7.444	7.444	72.21	0.003261502	0	0.093219152	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jun 10, 2014)	criteria provided, single submitter	0	0	1	0	0	2	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A120V	120	A	V	missense	possibly_wt-like	0.718344916094181	0.406612411609102	4	0.203306205804551	0.319872074883774	1.11681775730459	1.12652668599507	0.247873499059221	0.519158187081724	0.979821292240714	NA	NA	NA	NA	0.63703680464662	0.843087660239495	0.422489034881656	0.548674190724094	0.725399418569147	NA	NA	NA	NA	p.Ala120Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.125	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.607	-1.613	0.006	19.441	19.441	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.725	Deleterious	TOLERATED	neutral	TOLERATED	pathogenic	D	D	T	T	D	D	0.571428571428571
A120W	120	A	W	missense	low	0.330289771678847	0.224689697255722	5	0.100484287381528	0.133344187398878	0.527235355958815	0.432349265296719	0.55765808780985	0.425384627328592	-0.0245839211160514	NA	0.260640799075124	NA	NA	0.502682717441272	0.51281434354871	0.565294516757689	0.502682717441272	0.284915964255634	NA	0.419804469961902	NA	NA	p.Ala120Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.607	-5.682	4.075	0.435	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A120X	120	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A120Y	120	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala120Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	102.3	34	0.978	9.5	-162.7	-133	131.8	0	-7.4	0	1	40.22	0	0	0	0	8	18.5207283296311	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.607	-4.441	2.834	1.534	NA	72.21	0.003261502	0	0.093219152	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121A	121	A	A	synonymous	wt-like	1.12621828650133	0.101114725099205	4	0.0505573625496024	1.02712767675078	1.22530889625189	NA	NA	NA	NA	1.25630351275637	1.05275523017852	1.15600428019513	1.03981012287531	0.832909123419719	NA	NA	NA	NA	0.849406090155498	0.810216040394594	0.910203539732924	0.816412156683941	p.Ala121=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A121C	121	A	C	missense	possibly_wt-like	0.904566394600414	0.245128335632254	3	0.141524910563287	0.627182666981119	1.18195012221971	1.04964799753191	0.621546621980871	NA	NA	NA	NA	NA	1.04250456428846	0.806510585468004	0.806510585468004	0.594746055794676	NA	NA	NA	NA	NA	0.817765434648304	p.Ala121Cys	0	0	NA	NA	NA	NA	NA	NA	NA	0.8335	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.291	-4.945	3.654	1.176	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121D	121	A	D	missense	low	0.200179743418701	0.267205712459883	5	0.119498027407312	-0.0340320865232112	0.434391573360614	0.596542109387633	NA	0.202208120770076	0.264395871296756	-0.124295742426212	NA	0.0620483580652527	NA	0.393225250264372	0.59093344333194	NA	0.393225250264372	0.411648497595822	0.333700043560072	NA	0.321006107962871	NA	p.Ala121Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.291	-4.138	2.847	1.252	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121E	121	A	E	missense	low	0.240164364576751	0.0923074489452843	4	0.0461537244726421	0.149704726857987	0.330624002295514	NA	0.25093780652256	0.238272443910628	0.123022875751435	0.34842433212238	NA	NA	NA	0.417407357701203	NA	0.423901629051312	0.410913086351094	0.349649152514434	0.510278873279568	NA	NA	NA	p.Ala121Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.291	-3.956	2.665	1.503	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A121F	121	A	F	missense	wt-like	1.09698040613671	0.14791884091803	6	0.0603876139321817	0.978622857717327	1.2153379545561	0.978563799223513	1.00384399319924	0.926422266190643	1.26311588446236	1.26280080487882	NA	1.1471356888657	NA	0.811164545827173	0.77269039305091	0.770978710030186	0.748417861143572	0.849638698603435	0.851833074540331	NA	0.905426975038667	NA	p.Ala121Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-0.77	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.291	-3.059	1.768	10.617	10.617	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121G	121	A	G	missense	low	0.481194726696322	0.152480891525584	8	0.0539101361995555	0.375532801343544	0.5868566520491	0.232468439047718	0.500399931025633	0.530063601971306	0.603500187386868	0.309597033339106	0.692182075476035	0.423474158608833	0.557872386715076	0.546461124209582	0.417715739849183	0.538899470109691	0.554022778309472	0.560363218046937	0.495775408439691	0.632499379700539	0.515667656154966	0.574359865119053	p.Ala121Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.291	-2.751	1.46	18.218	18.218	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A121H	121	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.291	-5.122	3.831	0.74	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121I	121	A	I	missense	wt-like	1.11934116990608	0.22264224795483	4	0.111321123977415	0.901155776191829	1.33752656362033	NA	NA	NA	NA	1.41699909181324	0.920878302705486	1.15862877672171	0.980858508383886	0.84811789525763	NA	NA	NA	NA	0.909431967664623	0.7452175044042	0.911617076221795	0.786803822850637	p.Ala121Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.291	-2.406	1.115	11.319	11.319	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A121K	121	A	K	missense	low	0.226092244867501	0.17989491926751	5	0.0804514536577978	0.0684102931943246	0.383774196540678	NA	0.193555178714749	0.245965435939275	0.51197934807765	NA	0.0226292226677869	NA	0.156332038938046	0.39744920335623	NA	0.39744920335623	0.414686133234265	0.520226612915362	NA	0.302495064050801	NA	0.372687005654739	p.Ala121Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.291	-3.968	2.677	1.848	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121L	121	A	L	missense	wt-like	1.06013064436031	0.278399936719902	5	0.124504236687468	0.816106824530222	1.3041544641904	0.640549831163367	1.12375773529217	1.02543212406865	1.09356010269996	NA	1.4173534285774	NA	NA	0.796977489735259	0.61187128400134	0.826256927039635	0.796977489735259	0.77527974919105	NA	0.989916535202595	NA	NA	p.Ala121Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.291	-2.909	1.618	27.861	27.861	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.38	Deleterious	DAMAGING	effect	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A121M	121	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.291	-4.623	3.332	3.698	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121N	121	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.291	-4.302	3.011	1.405	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121P	121	A	P	missense	low	0.0962205493791599	0.164959184340895	6	0.0673443050034836	-0.0357718629915484	0.228212961749868	NA	-0.0541278522755556	0.206574741660507	0.254533216888482	-0.159616021164957	0.139444279894831	NA	0.190514931271652	0.374962656223815	NA	0.283271494465877	0.395366870232167	0.407323215304686	0.32050658336905	0.360070015536872	NA	0.389855296910758	p.Ala121Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.291	-4.192	2.901	1.061	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A121Q	121	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.291	-4.411	3.12	1.213	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121R	121	A	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.291	-4.292	3.001	1.815	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121S	121	A	S	missense	low	0.501170639731953	0.14706373352878	3	0.0849072861408726	0.334755416870805	0.6675858625931	NA	0.332104236768882	0.599493520733711	0.571914161693266	NA	NA	NA	NA	0.546511117798418	NA	0.461317987399641	0.588074852926197	0.546511117798418	NA	NA	NA	NA	p.Ala121Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.291	-2.973	1.682	5.621	5.621	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A121T	121	A	T	missense	low	0.338048905479989	0.143937328736566	7	0.0544031966022722	0.231420599495684	0.444677211464295	0.395404908912856	0.423612240382672	0.362024212959305	0.386674131416999	0.116300670362832	0.165712199141768	NA	0.516613975183493	0.471607446199303	0.495237086276888	0.503501637026255	0.471607446199303	0.465273817027611	0.423571904926584	0.37301675555638	NA	0.553637908093827	p.Ala121Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.291	-3.629	2.338	2.725	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	4	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.42	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A121V	121	A	V	missense	wt-like	1.12155048127224	0.208375878866568	5	0.0931885260033814	0.93890432653324	1.30419663601124	NA	NA	1.25461040358991	NA	1.26232192402336	1.14009333754468	1.19108924454939	0.759637496653858	0.853262608310226	NA	NA	0.909378541240109	NA	0.851654194425895	0.853262608310226	0.929100069723847	0.675695999549261	p.Ala121Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.291	-1.53	0.239	14.697	14.697	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	-0.02	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
A121W	121	A	W	missense	possibly_wt-like	0.721485406010141	0.523746891018276	4	0.261873445509138	0.208222884304818	1.23474792771546	0.0455631142628463	NA	NA	NA	1.26488070879075	0.963818938527647	NA	0.611678862459325	0.68388291705262	0.328790575066717	NA	NA	NA	0.852609997329252	0.766381771091471	NA	0.601384063013769	p.Ala121Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.291	-5.598	4.307	0.549	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A121X	121	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala121Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A121Y	121	A	Y	missense	possibly_wt-like	0.717441496865587	0.625705673089709	3	0.361251338791819	0.00940188346674342	1.42548111026443	NA	1.15225791737987	0.999741801319777	NA	0.000324771897113289	NA	NA	NA	0.784377607684898	NA	0.839395031336569	0.784377607684898	NA	0.38025051975736	NA	NA	NA	p.Ala121Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.7	101.1	30.7	0.917	14.3	-170.5	-111.8	107.9	1.65289256198347	-4.7	0	1	32.68	0	0	0	0	6	15.5941853862265	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.291	-4.339	3.048	2.462	NA	74.19	0.002962804	0	0.084681884	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122A	122	I	A	missense	low	0.263434455730978	0.104052205124331	4	0.0520261025621656	0.161465168453146	0.365403743008809	NA	0.313451625385931	0.283429837327142	0.344893138272873	NA	NA	NA	0.111963221937964	0.440005669617979	NA	0.452719447467324	0.433060641144843	0.446950698091114	NA	NA	NA	0.350402853526585	p.Ile122Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.352	-2.919	1.567	7.906	7.906	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122C	122	I	C	missense	low	0.333566830938785	0.217849751721864	7	0.0823394666047454	0.172184441887245	0.494949219990324	NA	0.434843667938428	0.473019740125035	0.649503388858794	0.0909874738333416	0.10723561384813	0.145970547994512	0.433407383973252	0.508679136109486	NA	0.508679136109486	0.526045475805882	0.580537992952886	0.414116468484826	0.344195243661654	0.366206044975477	0.511847559331751	p.Ile122Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.352	-3.715	2.363	35.857	35.857	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122D	122	I	D	missense	low	0.16812573894914	0.139757876896588	6	0.0570559143218909	0.0562982017732313	0.27995327612505	0.276154231252867	0.109562887398891	0.29110503435218	0.265530915552028	-0.0705787490080579	NA	NA	0.136980114146935	0.387556906016584	0.438500413988172	0.35873017061284	0.436824960424678	0.412146273003309	0.353765372587796	NA	NA	0.362967539029858	p.Ile122Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.352	-4.269	2.917	2.395	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122E	122	I	E	missense	low	0.149577895049741	0.13837285537875	7	0.0523000233620112	0.0470717328695953	0.252084057229886	-0.0214126531612079	0.223563831594261	0.327848298405726	0.307945901529945	0.0679789782066898	NA	0.0249318505670306	0.11618905820574	0.40552192501163	0.296925077593751	0.411282687301291	0.454845784753957	0.43074743047418	0.40552192501163	NA	0.301015402257244	0.35252527158113	p.Ile122Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.352	-4.119	2.767	2.588	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122F	122	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile122Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.352	-4.098	2.746	2.069	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I122G	122	I	G	missense	low	0.214501889296299	0.101844323450492	8	0.0360074058685996	0.143928670617127	0.28507510797547	0.245785322186445	0.280277674502073	0.325510005786018	0.22271852370649	0.258942587714962	0.268771766818155	0.0432302841553636	0.0707789495008829	0.423931801028283	0.424051600150987	0.437426814412828	0.453698963380962	0.39337083257671	0.476854056861926	0.423812001905579	0.310870817688123	0.329718132717518	p.Ile122Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.352	-4.003	2.651	2.76	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122H	122	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile122His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.352	-5.246	3.894	0.939	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122K	122	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile122Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.352	-4.111	2.759	2.964	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122L	122	I	L	missense	possibly_wt-like	0.785188297360375	0.270305564216292	3	0.15606099026373	0.479314377051809	1.09106221766894	NA	NA	NA	NA	0.50218535411983	NA	0.812684950511517	1.04069458744978	0.725294017114529	NA	NA	NA	NA	0.567714431409208	NA	0.725294017114529	0.816856377297923	p.Ile122Leu	1	0	NA	NA	NA	NA	NA	NA	NA	1.536	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.352	-2.26	0.908	11.648	11.648	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.48	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I122M	122	I	M	missense	possibly_low	0.64109416579844	0.28285423370027	4	0.141427116850135	0.363902110334838	0.918286221262042	0.616826178082267	0.69778995403518	NA	NA	0.968166169568327	NA	NA	0.281594361507986	0.61523853782692	0.600584126923781	0.629892948730059	NA	NA	0.741775892924683	NA	NA	0.435599763776492	p.Ile122Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.352	-4.395	3.043	1.857	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I122N	122	I	N	missense	low	0.298420609915238	0.00490118537290662	3	0.00282970069439589	0.292874498467194	0.303966721363282	NA	0.293776599003954	0.29794145667286	0.303543774068901	NA	NA	NA	NA	0.440177900585416	NA	0.44364959142725	0.440177900585416	0.428816870691551	NA	NA	NA	NA	p.Ile122Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.352	-4.443	3.091	2.824	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	1	0	0	1	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I122P	122	I	P	missense	low	0.149769761324378	0.204713035456042	7	0.0773742545642622	-0.00188099095220945	0.301420513600966	0.165180783250671	0.124443857519602	0.311056772227544	0.474150538848889	-0.152225656300815	NA	-0.0178313680588217	0.143613401783578	0.366299094856657	0.385701853211842	0.365590047398323	0.446610339393508	0.50363673032608	0.323267164205724	NA	0.277983415246727	0.366299094856657	p.Ile122Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.352	-4.329	2.977	1.706	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122Q	122	I	Q	missense	low	0.277159709878853	0.264638277347251	7	0.100023867035624	0.0811165328946076	0.473202886863098	NA	0.257976083787748	0.227895554087129	0.2491570425906	0.819095259237221	-0.0210375964518676	0.31112336106401	0.0959082648371303	0.405823715185781	NA	0.427146156419461	0.405823715185781	0.404965485780555	0.686092268918187	0.280972881448273	0.455156258911606	0.342339282518024	p.Ile122Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.352	-4.553	3.201	1.742	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122R	122	I	R	missense	low	0.238123244240613	0.124067512820627	7	0.0468931121008139	0.146214433400019	0.330032055081208	0.135928615554141	0.192431898984204	0.185435839631089	0.315838087015289	0.466485791240134	0.266901861113668	NA	0.103840616145769	0.396931390304751	0.37178435869609	0.396931390304751	0.384999243680785	0.434208560582265	0.554379294244124	0.422890376450993	NA	0.346323290549957	p.Ile122Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.352	-4.458	3.106	2.248	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122S	122	I	S	missense	low	0.193858106252861	0.402875252548282	7	0.152272532517871	-0.104590573316869	0.492306785822591	-0.102580418959894	0.106627970892357	0.18024556188928	NA	1.0840398168054	-0.0266212569109194	0.0620832297258114	0.0532118403279939	0.321024889608847	0.258307360538442	0.357377223496678	0.382453659182113	NA	0.785059083392086	0.278220847697865	0.321024889608847	0.320895086268931	p.Ile122Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.352	-3.904	2.552	5.936	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I122T	122	I	T	missense	low	0.249643954007888	0.147678235752421	4	0.0738391178762106	0.104921942320307	0.394365965695468	0.105199411284591	0.270275075580051	0.176510238753999	NA	NA	NA	NA	0.44659109041291	0.406718722700952	0.357164124861399	0.432815784649105	0.380621660752798	NA	NA	NA	NA	0.518469050274674	p.Ile122Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.352	-3.141	1.789	15.804	15.804	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I122V	122	I	V	missense	wt-like	1.00609395105509	0.144056111025281	7	0.0544480920874289	0.899377651536809	1.11281025057337	NA	1.04471609217669	0.708556989569356	1.11345279531776	1.10560370871263	0.942998221367513	1.02862889379349	1.09870095644819	0.789820059799394	NA	0.789820059799394	0.641565299767413	0.784003720197335	0.793114012730159	0.756119808217369	0.841599998200418	0.845989963419006	p.Ile122Val	1	0	NA	NA	NA	NA	NA	NA	NA	-0.445	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.352	-1.241	-0.111	15.766	15.766	43.18	0.003157518	0	0.090247124	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 16, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.235	Neutral	TOLERATED	neutral	TOLERATED	null	D	D	T	T	D	B	0.214285714285714
I122W	122	I	W	missense	low	0.0879205485893131	0.16454863627498	2	0.116353456545037	-0.140128035715706	0.315969132894332	NA	-0.0284329079557239	NA	0.20427400513435	NA	NA	NA	NA	0.340199195946412	NA	0.295116431362739	NA	0.385281960530085	NA	NA	NA	NA	p.Ile122Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.352	-5.641	4.289	0.435	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I122X	122	I	X	nonsense	low	0.017834031342148	0.10073253193338	7	0.0380733183470852	-0.056788301390067	0.0924563640743629	0.0719251699708115	0.210860383812626	-0.0254854936345889	-0.0630054758261231	NA	-0.0771624282272387	0.0417368191658122	-0.0340307558662634	0.281552356421697	0.341333022161435	0.405426611667381	0.281552356421697	0.26806613222198	NA	0.253310484636273	0.310066447312241	0.277077661845729	p.Ile122Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I122Y	122	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile122Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.5	97.3	30.5	0.809	14.1	169.1	-98	136.4	0	-6.7	0	1	33.88	0	0	0	0	6	12.3064494416546	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.352	-4.312	2.96	1.244	NA	43.18	0.003157518	0	0.090247124	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123A	123	H	A	missense	wt-like	0.92939795275468	0.125218453035012	8	0.0442714086353731	0.842627586284494	1.01616831922487	1.05528891931752	0.950263545413869	1.08792927911594	0.971882586717737	0.838041063696006	0.744376726453416	0.790238010874823	0.997163490448134	0.734098456181649	0.809194403598318	0.746279025336438	0.827629373317122	0.72191788702686	0.693169243558245	0.658224697730512	0.713204243735646	0.794992968411265	p.His123Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-0.884	-3.469	2.585	4.167	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123C	123	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-0.884	-5.294	4.41	0.67	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123D	123	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-0.884	-3.636	2.752	3.569	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Sep 14, 2016)	criteria provided, single submitter	0	1	0	0	0	2	0	2	2	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H123E	123	H	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-0.884	-3.421	2.537	7.663	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123F	123	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-0.884	-4.156	3.272	1.175	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123G	123	H	G	missense	wt-like	0.947056099967402	0.1543051207811	8	0.0545550986380626	0.840130071463769	1.05398212847103	0.805425124351624	1.06079866744241	0.849734458803953	1.14131948875879	0.919539516475563	0.73143777758893	0.924407772641633	1.14378599367631	0.754539594756293	0.690315077040402	0.79723385633424	0.710806137179714	0.796224701554229	0.723611998563955	0.651847443198113	0.785467190948631	0.868633835765054	p.His123Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-0.884	-3.514	2.63	2.963	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123I	123	H	I	missense	wt-like	1.07997988798962	0.127442557433817	7	0.0481687590594207	0.98557085505317	1.17438892092607	NA	1.26502522150147	0.992145428198257	1.18854460976357	1.17218753398744	0.9201300856915	1.01839759520493	1.00342874158019	0.816935351154541	NA	0.89137886071263	0.780651947782635	0.816935351154541	0.817985590177974	0.744848728671825	0.836089488379958	0.798139678618742	p.His123Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-0.884	-4.232	3.348	1.93	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123K	123	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-0.884	-3.587	2.703	6.707	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123L	123	H	L	missense	wt-like	0.98056341760564	0.262803572493416	8	0.0929150941150724	0.798453179519949	1.16267365569133	1.03563714520438	1.13332633462637	1.16973443988468	1.22021972394025	1.03162923492307	0.398034087717513	0.837442823425281	1.01848355112357	0.802772739190625	0.799844550921355	0.830667890297394	0.867750915847843	0.830826521294618	0.765481748491435	0.487521869720758	0.738628443887848	0.805700927459894	p.His123Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-0.884	-3.781	2.897	3.503	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H123M	123	H	M	missense	wt-like	1.25065704317806	0.12901819886519	2	0.0912296433140507	1.07185022796009	1.42946385839604	1.34188668649211	NA	NA	NA	NA	NA	NA	1.15942739986401	0.911020296604306	0.945550891577577	NA	NA	NA	NA	NA	NA	0.876489701631034	p.His123Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-0.884	-4.889	4.005	1.602	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123N	123	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-0.884	-2.51	1.626	11.081	11.081	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H123P	123	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-0.884	-4.089	3.205	1.834	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H123Q	123	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-0.884	-3.116	2.232	15.872	15.872	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H123R	123	H	R	missense	low	0.407828388074956	0.249447278768154	5	0.111556214425587	0.189182225549179	0.626474550600734	NA	0.465774086177335	0.488490140264108	0.585755761110719	NA	-0.0308641116957686	NA	0.529986064518389	0.533632971647395	NA	0.522937538372324	0.533632971647395	0.552581372555706	NA	0.276129660446847	NA	0.560354013979849	p.His123Arg	1	0	NA	NA	NA	NA	NA	NA	NA	15.02	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-0.884	-3.02	2.136	9.903	9.903	74.19	0.000728898	0	0.020833118	0	NA	NA	Cowden syndrome 1	Pathogenic(Last reviewed: Aug 1, 1997)	no assertion criteria provided	1	0	0	0	0	0	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
H123S	123	H	S	missense	wt-like	1.00145412752937	0.317213461087414	7	0.119895418651337	0.766463425061396	1.23644482999734	0.967575136399281	0.904227375259719	0.890943703248125	0.617717059326537	1.65945922740996	0.994481724427003	NA	0.975774666634959	0.767462245305476	0.767462245305476	0.725057125663816	0.731017312588315	0.566598049147215	1	0.781494620860075	NA	0.784250473210318	p.His123Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-0.884	-2.933	2.049	4.1	3.984	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.835	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123T	123	H	T	missense	wt-like	0.976850248109042	0.175113772675813	3	0.101101983793192	0.778694001108834	1.17500649510925	NA	0.961777982703935	1.15901299245033	NA	NA	NA	NA	0.809759769172863	0.751586987144257	NA	0.751586987144257	0.862492555553871	NA	NA	NA	NA	0.700869813532633	p.His123Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-0.884	-3.764	2.88	2.988	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123V	123	H	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-0.884	-3.963	3.079	2.525	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123W	123	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Trp	0	0	no	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-0.884	-5.385	4.501	0.492	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.18	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H123X	123	H	X	nonsense	low	-0.0781392548596916	0.0193920642863975	4	0.00969603214319877	-0.0971431286533039	-0.0591353810660793	-0.0954841756248294	-0.0936266913600837	-0.0568002891933939	-0.0666458632604593	NA	NA	NA	NA	0.265628566114161	0.26168358648938	0.265063194395951	0.266193937832371	0.266469634702063	NA	NA	NA	NA	p.His123Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H123Y	123	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His123Tyr	1	0	no	NA	NA	NA	NA	NA	NA	NA	39.7	95.7	27.2	0.99	22.5	169.5	-148.5	157	0	-5.4	0	1	28.47	2	47	0	0	9	9.47601487229733	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-0.884	-3.641	2.757	1.464	NA	74.19	0.000728898	0	0.020833118	0	NA	NA	not provided	Pathogenic(Last reviewed: Aug 6, 2014)	criteria provided, single submitter	1	0	0	0	0	8	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.18	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C124A	124	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys124Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-0.844	-2.645	1.801	7.763	7.763	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C124D	124	C	D	missense	wt-like	1.10300538193787	0.224780378432911	5	0.100524841236823	0.905980313562092	1.30003045031365	1.18368911174089	1.13691792798075	1.18998041026455	1.29080663027708	NA	NA	NA	0.713632829426089	0.861782517857639	0.870284200170415	0.83232355438883	0.877680601873004	0.861782517857639	NA	NA	NA	0.652590244822764	p.Cys124Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-0.844	-4.064	3.22	2.339	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124E	124	C	E	missense	wt-like	1.03768406843696	0.208682106958254	8	0.0737802664712388	0.893077403383567	1.18229073349036	0.689663941581236	1.24416456009392	1.0977428058869	0.86466944864529	1.2027151599545	1.10630801532263	1.2422467422845	0.853961873726722	0.830915627475125	0.635238624482838	0.881762446879483	0.832442441686126	0.674899400087597	0.829388813264123	0.836610745664683	0.956653160000667	0.7230702346586	p.Cys124Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-0.844	-4.149	3.305	3.351	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124F	124	C	F	missense	low	0.413096833563497	0.148606368348763	6	0.0606682958304258	0.294189158732441	0.532004508394553	NA	0.392538735494221	0.631442449447237	0.534498433283686	0.215913044595699	NA	0.327000593892184	0.377187744667957	0.48639431447671	NA	0.489177274226062	0.603744283682705	0.530102392439031	0.460780894801652	NA	0.463707631610208	0.483611354727358	p.Cys124Phe	1	0	NA	NA	NA	NA	NA	NA	NA	13.682	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-0.844	-4.229	3.385	3.816	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C124G	124	C	G	missense	possibly_wt-like	0.816647893296581	0.287948882883918	7	0.108834447772816	0.603336295384557	1.0299594912086	0.909487292186982	0.93963812335766	0.777698215561396	0.906811468001892	0.859251269766384	0.206665455107579	NA	1.11698342909417	0.701092057857158	0.73982541299809	0.741380884589693	0.675475784304054	0.693380847625991	0.701092057857158	0.393201496987833	NA	0.855172299781978	p.Cys124Gly	1	0	no	NA	NA	NA	NA	NA	NA	0.609	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-0.844	-3.69	2.846	2.349	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jul 23, 2014)	criteria provided, single submitter	0	1	0	0	0	2	0	0	2	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
C124H	124	C	H	missense	possibly_low	0.667966573997812	0.163444442453754	8	0.0577863368031521	0.554707435065133	0.781225712930492	0.608461710959817	0.691404007315257	0.869515928505715	0.830818894084743	0.555938790758257	0.464737322292938	0.485604793311744	0.837251144754028	0.611776822319494	0.596604509874147	0.626949134764841	0.720508007703545	0.660054187214372	0.587793373358264	0.520398072376549	0.549130805501903	0.714677303501585	p.Cys124His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-0.844	-3.434	2.59	22.753	22.753	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124I	124	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys124Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-0.844	-3.828	2.984	1.626	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C124K	124	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys124Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-0.844	-4.029	3.185	2.911	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124L	124	C	L	missense	low	0.398876294258155	0.141399748696034	8	0.0499923605805196	0.300893068018197	0.496859520498113	0.529072233541395	0.246834833881136	0.591801543302695	0.460313817797179	0.282998300339038	0.203157264323624	0.393502597470174	0.483329763409997	0.498546893167374	0.558832860673928	0.422010227714835	0.584302303654932	0.497568614983607	0.485839775497387	0.391472405559169	0.49952517135114	0.536920977402957	p.Cys124Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-0.844	-3.393	2.549	3.29	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C124M	124	C	M	missense	possibly_low	0.581501189925714	0.212915699087691	8	0.0752770673229903	0.433960849110856	0.729041530740572	0.928691866749258	0.472523687556111	0.562019820676268	0.567585203508668	0.179262704818835	0.722967114527399	0.631468634298282	0.587490487270889	0.579465641517226	0.748962498629509	0.526048991015125	0.569695784460229	0.544612646514744	0.447090606499848	0.647672484709032	0.627692106518545	0.589235498574222	p.Cys124Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-0.844	-4.711	3.867	0.938	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124N	124	C	N	missense	possibly_low	0.51565410455757	0.273130559701974	5	0.122147699645236	0.276249012458492	0.755059196656648	NA	0.119869901162769	0.728857535636205	0.80860309416406	0.507324503094272	NA	0.413615488730544	NA	0.56963409795294	NA	0.363481530495491	0.65152175257264	0.65031141392002	0.56963409795294	NA	0.510357841695854	NA	p.Cys124Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-0.844	-4.206	3.362	3.506	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124P	124	C	P	missense	possibly_wt-like	0.723189258925915	0.116890392486257	7	0.0441804155959099	0.63659723553592	0.80978128231591	0.603834534123352	0.77580314789099	0.58250863610325	0.626143341809146	0.768854318160672	0.843028862320679	0.862151972073315	NA	0.66585571816994	0.594403007786745	0.66585571816994	0.579744574436716	0.570293408316605	0.667325376930842	0.706847641308028	0.751936628093571	NA	p.Cys124Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-0.844	-4.268	3.424	1.171	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124Q	124	C	Q	missense	low	0.450052995695725	0.0296164258275155	3	0.0170990514239507	0.416539470734984	0.483566520656467	NA	NA	NA	NA	0.482883408493563	NA	0.441929693507504	0.425345885086108	0.525607685313608	NA	NA	NA	NA	0.560504424571123	NA	0.525607685313608	0.507798687179452	p.Cys124Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-0.844	-4.442	3.598	2.572	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C124R	124	C	R	missense	low	0.280032695674395	0.166284831715288	8	0.058790566057172	0.164805303571615	0.395260087777175	0.312322083212822	0.375374814583857	0.426339082198919	0.523480920625542	-0.00071262056717706	0.161791412874997	0.182485582548985	0.259180289917213	0.440025284279823	0.455708228688308	0.481264995547603	0.503150832182611	0.525270645282539	0.379863014429859	0.371084307082226	0.385872801327601	0.424342339871338	p.Cys124Arg	1	0	NA	NA	NA	NA	NA	NA	NA	11.04	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-0.844	-4.28	3.436	3.042	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	Cowden syndrome 1|not provided	Pathogenic(Last reviewed: Jun 30, 2016)	criteria provided, single submitter	1	0	0	0	0	2	0	2	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
C124S	124	C	S	missense	wt-like	1.13746760599211	0.258371764379297	6	0.10547983111198	0.930730935917262	1.34420427606696	NA	1.31064474411561	1.2211695051768	1.39746213467643	0.941359489186279	NA	0.713188378080039	1.2409813847175	0.900766911980423	NA	0.912408692881305	0.89297737027071	0.908556453690136	0.731762583769055	NA	0.671705820587914	0.917450032061504	p.Cys124Ser	1	0	no	1.25839305011505	0.214128975618955	1.09538893201943	1.42139716821068	NA	40.8	-0.236	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-0.844	-2.937	2.093	5.075	5.075	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	11	0	0	4	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	high	3.825	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
C124T	124	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys124Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-0.844	-3.622	2.778	1.895	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C124V	124	C	V	missense	low	0.389667514415497	0.252869704948984	8	0.0894029415630341	0.214440968840012	0.564894059990983	0.472036969964258	0.290653010161487	0.52756809904532	0.672792647480603	0.692564659917491	0.0174276102501916	0.0714797592168124	0.372817359287818	0.506556579339476	0.531696821516959	0.442209669539495	0.552798852754658	0.590751533215039	0.638828303720771	0.299931331346289	0.326085798308779	0.481416337161992	p.Cys124Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-0.844	-3.558	2.714	1.83	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C124W	124	C	W	missense	possibly_low	0.439363303882131	0.33253135985018	5	0.148712545055089	0.147892071524865	0.730834536239396	NA	0.923457875114796	0.372787683692504	NA	-0.0110385663063179	NA	0.463744101577583	0.447865425332089	0.519109082511755	NA	0.733922062456175	0.476886416923669	NA	0.376005883090333	NA	0.537356781369918	0.519109082511755	p.Cys124Trp	1	0	NA	NA	NA	NA	NA	NA	NA	11.836	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-0.844	-3.445	2.601	29.078	29.078	64.27	0.000660463	0	0.018877131	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C124X	124	C	X	nonsense	low	-0.00935698231239184	0.0673247227142223	3	0.0388699467821732	-0.0855406780864398	0.0668267134616561	NA	0.0683497893537413	-0.0501754423088181	-0.0462452939820988	NA	NA	NA	NA	0.275416335800579	NA	0.33973162601229	0.269443110299502	0.275416335800579	NA	NA	NA	NA	p.Cys124Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C124Y	124	C	Y	missense	low	0.507867404039742	0.208683133278982	5	0.0933259343538904	0.324951933882568	0.690782874196917	NA	0.284830439583212	0.726179298692824	NA	0.298882489581058	0.686410458083402	0.543034334258215	NA	0.580061976812274	NA	0.439525562494205	0.650208204669042	NA	0.491773121040364	0.629654707110676	0.580061976812274	NA	p.Cys124Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	15.407	39.5	92.5	25.3	0.048	67.4	-56.2	-129.3	-126.3	2.7027027027027	-1.4	0	0	34.28	0	0	0	0	9	6.50408624327815	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-0.844	-4.248	3.404	3.988	NA	64.27	0.000660463	0	0.018877131	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Oct 5, 2016)	criteria provided, multiple submitters, no conflicts	0	1	0	0	0	2	0	0	0	1	0	1	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K125A	125	K	A	missense	wt-like	1.03132143838353	0.0886516816242078	7	0.0335071861264755	0.965648560352359	1.0969943164147	1.04930083737605	1.07218365587193	1.08928963216784	1.12818591958574	0.853392293589395	NA	1.00566854400951	1.02122918608425	0.806345414817562	0.806345414817562	0.802482144395915	0.828296561821072	0.790464954551844	0.698903508623925	NA	0.829233705508366	0.807079917284032	p.Lys125Ala	0	0	NA	NA	NA	NA	NA	NA	NA	1.284	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.223	-3.441	2.218	8.106	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K125C	125	K	C	missense	possibly_wt-like	0.881168447412432	0.517317411340932	2	0.365798649585043	0.164216268632359	1.5981206261925	NA	0.515369797827388	NA	NA	NA	NA	NA	1.24696709699748	0.733128335596361	NA	0.545800326769045	NA	NA	NA	NA	NA	0.920456344423677	p.Lys125Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.223	-5.268	4.045	1.353	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125D	125	K	D	missense	wt-like	1.11801068090184	0.304851101747307	5	0.136333557304537	0.850801818700717	1.38521954310296	NA	1.24167916046299	1.27401088193201	1.31411472863819	0.579732756154979	NA	NA	1.18051587732101	0.880616719477803	NA	0.880616719477803	0.918893553613465	0.872004320316497	0.596681319503034	NA	NA	0.887081348458177	p.Lys125Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.223	-3.97	2.747	3.635	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125E	125	K	E	missense	wt-like	1.00954977744054	0.0788030174927643	4	0.0394015087463821	0.932324239361093	1.08677531551999	1.04957536340245	NA	1.07761511604383	1.01274496880744	NA	NA	NA	0.898263661508456	0.775898374673409	0.806476027854739	NA	0.82257076664148	0.739838147669669	NA	NA	NA	0.745320721492079	p.Lys125Glu	1	0	no	NA	NA	NA	NA	NA	NA	2.397	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.223	-3.613	2.39	3.83	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K125F	125	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.223	-4.38	3.157	1.589	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125G	125	K	G	missense	wt-like	1.18435686094925	0.110946009022209	8	0.0392253376625941	1.10747661184914	1.26123711004936	1.15117057177041	1.08300413506793	1.20619265296984	1.26912319797916	1.37751118560426	1.07898804059395	1.24642486097845	1.06244024263001	0.853542928814799	0.854812642424861	0.807470203201378	0.885631936227784	0.852273215204736	0.894681740962036	0.823145476229876	0.95890346712393	0.827778090359638	p.Lys125Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.223	-3.79	2.567	4.971	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K125H	125	K	H	missense	low	-0.165354450862333	0.258822436274747	2	0.183015099813096	-0.524057455123005	0.193348553398339	NA	NA	NA	NA	-0.348369550675429	0.0176606489507636	NA	NA	0.275023094878755	NA	NA	NA	NA	0.25	0.30004618975751	NA	NA	p.Lys125His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.223	-4.878	3.655	1.433	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125I	125	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.223	-3.114	1.891	6.064	6.064	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K125K	125	K	K	synonymous	wt-like	0.956604756682235	0.277994953161271	8	0.0982860582579859	0.763967622314177	1.14924189105029	0.751733566279237	1.06018262385747	1.14284430624022	0.752701079392878	1.4135242461846	0.512709417482572	1.02654896691023	0.992593847110673	0.794823872266662	0.664769894448574	0.796949870609325	0.854562583589407	0.625795499185567	0.908133981377182	0.544042207976809	0.840479763323404	0.792697873923999	p.Lys125=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K125L	125	K	L	missense	wt-like	0.933558095214583	0.0691004312047642	3	0.0398951525571898	0.85536503304476	1.01175115738441	NA	0.855584202174329	0.957884769029381	0.987205314440039	NA	NA	NA	NA	0.728637692884964	NA	0.702633441514601	0.763848723132047	0.728637692884964	NA	NA	NA	NA	p.Lys125Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.223	-2.055	0.832	10.902	10.902	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K125M	125	K	M	missense	possibly_wt-like	0.957427451832614	0.35046602076955	5	0.156733169248913	0.650236084921923	1.2646188187433	NA	0.925039604505646	NA	NA	1.41936154847244	0.947031986801929	1.05519705223887	0.440507067144181	0.758107941037793	NA	0.734651213085549	NA	NA	0.910314434592949	0.758107941037793	0.855909432800308	0.515413361409422	p.Lys125Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.223	-2.59	1.367	4.421	4.421	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125N	125	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.223	-2.954	1.731	9.51	9.51	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	1	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.25	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K125P	125	K	P	missense	wt-like	0.966106113208759	0.282136568053845	8	0.099750340245787	0.7705990388814	1.16161318753612	0.660169420524871	0.779783771569567	1.16048461326184	1.34606477502978	1.19540757605736	1.06118175561526	0.989286285487064	0.536470708124322	0.817389786980705	0.62120582392921	0.667690718693624	0.863214315604499	0.886016062403151	0.826659154250031	0.814369244653818	0.820410329307591	0.563610913631044	p.Lys125Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.223	-4.171	2.948	2.16	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125Q	125	K	Q	missense	possibly_low	0.685139953983354	0.23811137376208	3	0.137473665738648	0.415696520312906	0.954583387653803	NA	0.411900279649205	0.848256707804839	0.795262874496019	NA	NA	NA	NA	0.644461040024567	NA	0.49810262023526	0.710081370563481	0.644461040024567	NA	NA	NA	NA	p.Lys125Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.223	-3.373	2.15	5.892	5.892	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.365	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K125R	125	K	R	missense	wt-like	0.918848929356298	0.0872502134895964	8	0.0308476088092338	0.858388727081019	0.979309131631577	1.01781652970189	0.89665787127748	0.934624002954873	0.823094367042795	0.904564158554061	0.775778732997727	0.995901233408744	1.00235453891281	0.737004067427214	0.791365920513648	0.721567711719418	0.752440423135011	0.656666583975034	0.718018135898117	0.673701889166886	0.823973096552508	0.797600162416262	p.Lys125Arg	1	0	NA	NA	NA	NA	NA	NA	NA	1.792	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.223	-2.597	1.374	9.22	9.22	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.815	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K125S	125	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.223	-3.167	1.944	16.317	16.317	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K125T	125	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.223	-3.76	2.537	6.094	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	1	1	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K125V	125	K	V	missense	wt-like	0.965959627332135	0.147007276733341	7	0.055563527879039	0.857057113835232	1.07486214082904	1.21288176269126	1.02184573516719	0.937089310716763	1.01277731147202	0.795359805500676	NA	0.785596482047616	0.996166983729422	0.753649539397243	0.884173378015864	0.779277210116035	0.753649539397243	0.739852331595067	0.67722617909185	NA	0.710704346976412	0.794492474848039	p.Lys125Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.223	-3.137	1.914	5.612	5.612	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125W	125	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.223	-5.599	4.376	0.372	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K125X	125	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K125Y	125	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys125Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	92	21.9	0.921	129	-2	-88.6	-66.3	15.6521739130435	-3.2	0	0	40.63	0	0	2	52	6	5.97001489612882	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.223	-4.446	3.223	1.335	NA	74.19	0.001408351	0	0.04025302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126A	126	A	A	synonymous	possibly_wt-like	0.777316024252244	0.297486451289966	7	0.112439309789197	0.556939026618876	0.997693021885613	0.564579313129188	0.959217801974575	0.972408952906094	1.09071562439676	0.249616261871568	0.666977847675774	NA	0.937696367811751	0.750406786914735	0.575726295395079	0.750406786914735	0.770972144877783	0.774032298847252	0.473370321366703	0.620076904145667	NA	0.765125721613805	p.Ala126=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A126C	126	A	C	missense	wt-like	1.1259251164455	0.0895860022101694	6	0.0365733322517935	1.05424270243737	1.19760753045363	1.24181881335058	1.07135975885116	1.04612479787988	1.03731266776825	1.22285936580833	NA	NA	1.13607529501479	0.822019849358084	0.897940947244617	0.802102341735165	0.807126262558264	0.750612349912831	0.836913436157904	NA	NA	0.864761152344454	p.Ala126Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.112	-4.986	3.874	1.347	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.595	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126D	126	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.112	-3.237	2.125	7.974	7.974	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	1	1	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A126E	126	A	E	missense	wt-like	0.92488341633877	0.116511787733436	8	0.04119313759724	0.844146350237977	1.00562048243956	0.823241510435153	0.909454746435168	0.860238562363889	0.906357322026709	1.11693264861226	0.762569398077826	0.97720684674054	1.04306629601862	0.721712378218325	0.698791695189881	0.727466855801346	0.715957900635305	0.693181681208642	0.797345800329509	0.667191368732021	0.813904423408916	0.818047563318311	p.Ala126Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.112	-3.816	2.704	1.842	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126F	126	A	F	missense	possibly_low	0.618592456963401	0.235945562495306	7	0.0891790401874041	0.443804750020239	0.793380163906564	0.822986759226042	0.575636986936806	0.73011687244495	0.933766647624282	0.217871274981649	0.509275203425272	NA	0.540493454104811	0.573582486678272	0.698670490546435	0.573582486678272	0.652139397411397	0.70520208319289	0.461512367926	0.542349577656409	NA	0.56563132998341	p.Ala126Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.112	-4.451	3.339	3.327	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126G	126	A	G	missense	wt-like	1.03266755426131	0.139462244597428	8	0.049307349437169	0.936026925191327	1.12930818333129	0.963230848437114	0.750979057436162	0.945117129224893	1.15102400495326	1.15935768129749	1.0830700197083	1.07728910790629	1.13127258512697	0.806836893481729	0.765395335101912	0.654412230248759	0.757586802751732	0.800480632087976	0.813193154875482	0.825157372256422	0.867808068018096	0.86234900063513	p.Ala126Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.112	-1.396	0.284	15.561	15.561	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	2	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.885	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
A126H	126	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.112	-4.995	3.883	0.643	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.595	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126I	126	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.112	-3.325	2.213	20.146	20.146	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126K	126	A	K	missense	possibly_wt-like	0.817497156178844	0.468371373517166	5	0.209462045979866	0.406959089930234	1.22803522242745	NA	1.3690357218387	1.14683606429599	0.835773467023497	0.194347108435375	NA	0.541493419300656	NA	0.662227022812683	NA	0.939325950917244	0.856520351156903	0.662227022812683	0.452725201857722	NA	0.57923205019713	NA	p.Ala126Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.112	-3.842	2.73	3.207	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126L	126	A	L	missense	possibly_low	0.57684706423474	0.167195472976603	6	0.0682572660159951	0.44306528116022	0.71062884730926	0.637924279801567	0.687728523074402	NA	NA	0.640115753624802	0.608694463504006	0.23951461613635	0.647104749267311	0.61489937707185	0.610622108314335	0.625254798386586	NA	NA	0.619236653203127	0.591350615807585	0.416588262020553	0.619176645829364	p.Ala126Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.112	-3.61	2.498	12.434	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.595	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A126M	126	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.112	-4.91	3.798	2.74	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126N	126	A	N	missense	wt-like	1.08184198377411	0.418979261537587	6	0.171047567262532	0.746594912296356	1.41708905525186	NA	1.09648579032744	1.31483314715456	1.31009848618949	0.250622007678168	1.35186946525176	NA	1.16714300604325	0.875303920421815	NA	0.813685019385699	0.938914934109947	0.870242991000761	0.473746005470439	0.957641278047505	NA	0.880364849842868	p.Ala126Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.112	-4.007	2.895	1.394	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.245	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126P	126	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.112	-4.081	2.969	1.233	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A126Q	126	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.112	-4.289	3.177	1.279	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126R	126	A	R	missense	possibly_wt-like	0.823718039449578	0.261594770133098	5	0.116988737715208	0.594424326930968	1.05301175196819	1.06752800291256	0.878175293902513	0.843660242544984	0.947714101570109	NA	NA	NA	0.381512556317718	0.71131876061674	0.815017472185202	0.713047554603183	0.707827022858749	0.71131876061674	NA	NA	NA	0.485783482975193	p.Ala126Arg	0	0	NA	NA	NA	NA	NA	NA	NA	3.572	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.112	-3.365	2.253	9.135	9.135	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.595	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126S	126	A	S	missense	wt-like	1.08663809349629	0.356090826757564	5	0.159248658958803	0.774516457350738	1.39875972964185	NA	1.00041321947001	1.14913367685251	1.57245072234864	0.578930683213373	NA	NA	1.13226216559694	0.857647220892737	NA	0.769397181079421	0.857647220892737	0.985297968507341	0.596381714918833	NA	NA	0.862846015503383	p.Ala126Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.112	-3.391	2.279	2.452	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	2	2	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A126T	126	A	T	missense	wt-like	1.01959242149309	0.195505506189154	8	0.0691216345928297	0.884116507138606	1.15506833584757	0.989199083345555	0.89334298848869	1.18276093704444	0.796674244594545	0.974956167630754	1.30640214420962	0.79481381359142	1.2185899930397	0.761031312779024	0.777750411507578	0.720039606541801	0.874139793455442	0.645079998556488	0.74431221405047	0.935231677219123	0.715668740845965	0.906203999098571	p.Ala126Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.112	-3.118	2.006	6.529	6.529	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	7	0	0	1	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A126V	126	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.112	-3.075	1.963	19.441	19.441	72.21	0.001179662	0	0.033716708	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Sep 15, 2016)	criteria provided, single submitter	0	1	0	0	0	3	2	0	3	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.595	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A126W	126	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.112	-5.569	4.457	0.395	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A126X	126	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A126Y	126	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala126Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	93.2	22.4	0.291	99.5	-112.3	-108.7	8.7	36.3636363636364	-0.6	0	0	40.43	0	0	0	0	6	6.11390855836101	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.112	-4.551	3.439	1.534	NA	72.21	0.001179662	0	0.033716708	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127A	127	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.631	-3.101	2.47	4.167	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G127C	127	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.631	-5.306	4.675	0.67	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127D	127	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.631	-2.89	2.259	9.155	9.155	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127E	127	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.631	-2.961	2.33	21.45	21.45	72.21	0.000486559	0	0.01390667	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Oct 22, 2015)	criteria provided, single submitter	0	1	0	0	0	5	1	0	0	0	1	2	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G127F	127	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.631	-4.5	3.869	1.175	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127H	127	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.631	-4.818	4.187	2.272	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127I	127	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.631	-4.405	3.774	1.93	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127K	127	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.631	-3.782	3.151	6.707	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127L	127	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.631	-3.974	3.343	3.503	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127M	127	G	M	missense	low	0.54421044019362	0.0860125808316215	5	0.0384659955319402	0.468818474321538	0.619602406065701	NA	0.463062851133207	0.650329604639631	0.492624331246	0.49144519136674	NA	0.623590222582521	NA	0.563702574346128	NA	0.521687704645871	0.613007535453314	0.511738440453763	0.563702574346128	NA	0.623448846021983	NA	p.Gly127Met	0	0	NA	NA	NA	NA	NA	NA	NA	12.959	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.631	-5.076	4.445	1.602	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127N	127	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.631	-3.643	3.012	3.314	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G127P	127	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.631	-4.049	3.418	1.89	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127Q	127	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.631	-3.2	2.569	15.872	15.872	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127R	127	G	R	missense	low	0.490890563241277	0.000850458777151502	2	0.000601365168443446	0.489711909169571	0.492069217312983	NA	NA	NA	NA	NA	NA	0.49149192840972	0.490289198072833	0.546358958754329	NA	NA	NA	NA	NA	NA	0.552301577568713	0.540416339939945	p.Gly127Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.631	-4.064	3.433	5.383	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	PTEN hamartoma tumor syndrome|not provided	Pathogenic/Likely pathogenic(Last reviewed: Nov 8, 2016)	criteria provided, single submitter	1	0	0	0	0	7	0	4	0	0	0	2	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G127S	127	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.631	-3.369	2.738	4.1	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.605	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G127T	127	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.631	-3.816	3.185	2.988	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.605	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G127V	127	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.631	-3.936	3.305	2.525	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	not provided	Uncertain significance	no assertion criteria provided	0	0	1	0	0	3	0	2	0	1	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G127W	127	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.631	-5.335	4.704	0.492	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G127X	127	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G127Y	127	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly127Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	94	26.1	0.94	81.9	104.8	62.1	51.3	1.03092783505155	-0.3	0	0	34.89	0	0	0	0	9	6.40402825259227	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.631	-4.554	3.923	1.464	NA	72.21	0.000486559	0	0.01390667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128A	128	K	A	missense	possibly_low	0.460194248238517	0.448046147690773	4	0.224023073845387	0.0211170917956023	0.899271404681432	0.443447591091643	0.439014511873753	NA	NA	NA	-0.0689245807833534	NA	1.02723947077203	0.514348245665398	0.518094666360589	0.510601824970207	NA	NA	NA	0.257370694665615	NA	0.810098571090275	p.Lys128Ala	0	0	NA	NA	NA	NA	NA	NA	NA	0.076	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1	-3.366	2.366	3.239	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128C	128	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1	-5.253	4.253	0.729	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128D	128	K	D	missense	wt-like	1.15875446518548	0.144599087434571	6	0.0590323302477982	1.04305322397632	1.27445570639463	NA	1.28574422360519	1.23264463318205	1.3363585095356	1.0403736061117	NA	0.986428294948062	1.07097752373025	0.856912643957661	NA	0.900929971990778	0.898605375056494	0.881759364711318	0.768748101909143	NA	0.818871034486348	0.832065923204003	p.Lys128Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1	-3.843	2.843	6.182	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128E	128	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1	-3.45	2.45	3.672	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K128F	128	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1	-4.409	3.409	1.454	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128G	128	K	G	missense	wt-like	1.17545420502553	0.0697420190169555	4	0.0348710095084778	1.10710828228436	1.2438001277667	NA	1.24705082180259	1.10817664636718	1.22294432392675	NA	NA	NA	1.12364502800559	0.848038909666405	NA	0.883092964952667	0.83755974444129	0.83202139881787	NA	NA	NA	0.85851807489152	p.Lys128Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1	-3.685	2.685	4.751	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128H	128	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1	-4.763	3.763	2.377	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128I	128	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1	-3.273	2.273	7.277	7.277	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128L	128	K	L	missense	wt-like	0.979795106577036	0.173823667866748	8	0.0614559471396477	0.85934366354753	1.10024654960654	1.14856834580477	0.705871064394435	0.733195102573532	1.11681281810323	1.0882420195595	1.09613831457152	0.935706234744682	1.01382695286462	0.789090616533603	0.853574564413643	0.633618204604152	0.653649122957594	0.78547726336839	0.786628765080074	0.831598377899156	0.791552467987131	0.803362160032266	p.Lys128Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1	-2.763	1.763	9.97	9.97	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128M	128	K	M	missense	wt-like	1.21968691754827	0.211164116142028	4	0.105582058071014	1.01274988631547	1.42662394878107	NA	1.2103991599311	1.03286888209269	1.51718262542006	1.11829700274924	NA	NA	NA	0.833411015840574	NA	0.866197165661214	0.800624866019935	0.96106005941976	0.797855438209941	NA	NA	NA	p.Lys128Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1	-2.85	1.85	4.702	4.702	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K128N	128	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1	-3.148	2.148	23.499	23.499	74.19	0.001029297	0	0.02941902	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jun 16, 2016)	criteria provided, single submitter	0	1	0	0	0	9	1	0	2	0	0	1	1	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K128P	128	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1	-4.036	3.036	1.429	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128Q	128	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1	-3.845	2.845	2.543	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	2	0	0	1	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K128R	128	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1	-2.382	1.382	8.878	8.878	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.565	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K128S	128	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1	-3.509	2.509	5.229	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128T	128	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1	-2.876	1.876	6.834	6.834	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K128V	128	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1	-3.622	2.622	4.724	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128W	128	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1	-5.546	4.546	0.269	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K128X	128	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K128Y	128	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys128Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.3	91.3	27.5	0.382	78.8	6.2	-121.1	-102.4	36.9565217391304	-2	0	0	35.16	2	39	0	0	7	5.20410778712355	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1	-4.411	3.411	1.164	NA	74.19	0.001029297	0	0.02941902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129A	129	G	A	missense	possibly_low	0.690961977489697	0.26833059888361	5	0.120001091909396	0.4557641592418	0.926159795737595	0.238918602926003	0.806193404728827	0.824049199491779	0.919156553707806	NA	NA	NA	0.666492126594072	0.679865115117563	0.420784576365267	0.679865115117563	0.698208738504351	0.698794803988647	NA	NA	NA	0.62891391842139	p.Gly129Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.742	-2.267	1.525	8.338	8.338	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G129C	129	G	C	missense	low	0.51194667043198	0.0672258554547144	3	0.0388128657432822	0.435874851438358	0.588018489425601	0.564320253181313	NA	NA	NA	NA	0.436140613503325	NA	0.535379144611302	0.563062677977575	0.575603040754903	NA	NA	NA	NA	0.506303535590737	NA	0.563062677977575	p.Gly129Cys	0	0	NA	NA	NA	NA	NA	NA	NA	2.464	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.742	-5.237	4.495	0.617	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129D	129	G	D	missense	possibly_low	0.652044576276189	0.451920061111759	3	0.260916168935066	0.140658282179291	1.16343087037309	0.846530422805005	NA	NA	NA	NA	0.135441207499531	NA	0.974162098524031	0.709872012845235	0.709872012845235	NA	NA	NA	NA	0.358097010477202	NA	0.78344056400988	p.Gly129Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.742	-2.752	2.01	29.434	29.434	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129E	129	G	E	missense	possibly_wt-like	0.755334938294823	0.35058553502454	6	0.143125945335127	0.474813240184725	1.03585663640492	NA	0.286736650206793	0.697146799238813	0.613583479807517	0.738039291442328	1.35902405659254	NA	0.837479352480945	0.645891971308246	NA	0.440404293510992	0.635969143824089	0.564785261478449	0.655814798792403	0.961167580727368	NA	0.714791920389014	p.Gly129Glu	1	0	no	NA	NA	NA	NA	NA	NA	3.119	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.742	-3.039	2.297	7.961	7.961	74.19	0.000616203	0	0.017612096	0	NA	NA	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not provided	Pathogenic(Last reviewed: Mar 1, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	9	3	0	1	0	4	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
G129F	129	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.742	-4.509	3.767	1.052	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129G	129	G	G	synonymous	wt-like	1.04942979141864	0.0945071827997859	8	0.0334133349142826	0.983940858383272	1.11491872445401	1.00552162262126	1.14650927484272	1.07800812675333	1.10536647462638	1.1315773309775	1.04920262155194	1.0300737843518	0.849179095624192	0.805640599895384	0.785516292423123	0.83674500387406	0.82276351971168	0.780457451795438	0.802816143166415	0.808465056624353	0.842378206708574	0.720668093649706	p.Gly129=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G129H	129	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.742	-4.842	4.1	1.32	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129I	129	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.742	-4.342	3.6	1.708	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129K	129	G	K	missense	low	0.333841802150911	0.153372129440744	2	0.108450472772571	0.121282781410331	0.546400822891492	NA	NA	0.442292274923482	0.22539132937834	NA	NA	NA	NA	0.45275905522996	NA	NA	0.510975114836475	0.394542995623445	NA	NA	NA	NA	p.Gly129Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.742	-3.818	3.076	3.383	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129L	129	G	L	missense	low	0.432872020655971	0.0977042682261865	7	0.0369287422508628	0.360493015849917	0.505251025462024	0.41739157150372	0.304625582803963	0.500690932730528	0.374197355634305	0.37205377271642	NA	0.460721848559384	0.600423080643474	0.519105363186954	0.50569782406571	0.448650790375441	0.539616880354987	0.459802107778822	0.519105363186954	NA	0.53572901586268	0.595730868467129	p.Gly129Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.742	-3.93	3.188	2.103	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129M	129	G	M	missense	low	0.495047448383101	0.11479750904353	4	0.0573987545217648	0.382547956762986	0.607546940003216	0.334157232912554	0.559446535739263	0.494062780575419	0.592523244305169	NA	NA	NA	NA	0.545957674775253	0.466096880201224	0.566118961154358	0.536366086809784	0.555549262740721	NA	NA	NA	NA	p.Gly129Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.742	-5.092	4.35	0.642	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129N	129	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.742	-3.019	2.277	5.147	5.108	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129P	129	G	P	missense	wt-like	0.804005719641641	0.104942763733531	6	0.0428427038907672	0.720035563015423	0.887975876267858	NA	0.832772905099311	0.755612144708701	0.714618770192169	0.976714611189315	NA	0.849773919722711	0.694541966937638	0.678380716969069	NA	0.692117817467088	0.66464361647105	0.60909444379289	0.744969059237328	NA	0.745269890880711	0.643001896232142	p.Gly129Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.742	-4.069	3.327	1.712	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129Q	129	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.742	-4.222	3.48	2.28	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129R	129	G	R	missense	low	0.488615062431636	0.156169766781228	7	0.0590266236014408	0.37292500604381	0.604305118819462	0.550963300325261	0.409363167044253	0.520716175326015	0.311447830704823	0.792492249685068	0.39180696053151	NA	0.44351575340452	0.516924468237696	0.569248116222479	0.496933054022864	0.549438309894795	0.432283206911018	0.676155038521908	0.484452688793723	NA	0.516924468237696	p.Gly129Arg	1	0	conflict	0.225558174304668	-1.62377640004554	0.123709178040299	0.327407170569036	NA	NA	3.627	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.742	-4.101	3.359	2.195	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	not provided	Pathogenic(Last reviewed: Nov 23, 2016)	criteria provided, single submitter	1	0	0	0	0	11	1	0	0	0	1	1	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G129S	129	G	S	missense	possibly_wt-like	0.720834152451406	0.262950456597705	7	0.0993859307554874	0.526041307600659	0.915626997302153	NA	0.776408318751115	0.866188954126026	1.0145110414154	0.456110739298728	0.38192961115912	0.537104407199806	1.01358599520965	0.666134691751699	NA	0.666134691751699	0.718876284926901	0.740612661533773	0.550503819880481	0.479584413038646	0.576868157278306	0.803241139518247	p.Gly129Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.742	-3.367	2.625	3.879	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.605	Deleterious	DAMAGING	effect	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G129T	129	G	T	missense	possibly_low	0.663585889820442	0.135026076177785	8	0.0477389270511615	0.57001931213958	0.757152467501303	0.73646403173572	0.775057574502784	0.542510908915831	0.514470221353638	0.553002482607237	0.89502989040184	0.703453210691024	0.588698798355459	0.623673689463756	0.657505008458854	0.665512021385649	0.560127590649851	0.521318989229497	0.586696551190308	0.732477527900299	0.66646252375353	0.589842370468658	p.Gly129Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.742	-3.78	3.038	2.623	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129V	129	G	V	missense	low	0.541607665135278	0.206608628330862	8	0.0730471810722019	0.398437821061586	0.684777509208969	0.882307085160649	0.138044999565221	0.634240287021865	0.561019678974633	0.572066437599941	0.551312078695198	0.442620603593128	0.551250150471586	0.567051132641096	0.726893708717219	0.371859944980131	0.605116490010394	0.541733325611513	0.593817659524138	0.563068405449199	0.525979804920804	0.571033859832993	p.Gly129Val	1	0	NA	NA	NA	NA	NA	NA	NA	3.242	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.742	-3.885	3.143	1.966	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	4	0	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G129W	129	G	W	missense	wt-like	0.914434849095176	0.07132102337508	6	0.0291166858670096	0.857367193446671	0.971502504743681	NA	0.881707828447558	0.85866365165522	0.923873287781644	0.953615785915218	NA	0.837336734982518	1.0314118057889	0.725763128012068	NA	0.714675993577451	0.71518548180028	0.70086333498619	0.736340774223856	NA	0.738571305353514	0.812194118245509	p.Gly129Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.742	-5.418	4.676	0.224	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G129X	129	G	X	nonsense	low	0.17804414965812	0.505696726745662	5	0.226154451400487	-0.265210430030249	0.621298729346489	NA	-0.0960199224117533	0.176107508353407	NA	-0.199726672128953	NA	-0.0388450581408247	1.04870489261872	0.305523737943513	NA	0.263959955158155	0.380424140636171	NA	0.305523737943513	NA	0.26666558060836	0.820879537504727	p.Gly129Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G129Y	129	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly129Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.4	88.1	29.2	0.88	127.1	45.2	-56.5	-50.5	8.24742268041237	-2.1	1	0	30.26	0	0	0	0	6	4.56953803573184	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.742	-4.583	3.841	0.828	NA	74.19	0.000616203	0	0.017612096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130A	130	R	A	missense	wt-like	1.27756247327141	0.168406279041692	3	0.0972294105379439	1.08699633037898	1.46812861616384	NA	1.10380969066154	1.28882039644743	1.44005733270526	NA	NA	NA	NA	0.926156916473538	NA	0.817061214181708	0.926156916473538	0.927236643433678	NA	NA	NA	NA	p.Arg130Ala	0	0	NA	NA	NA	NA	NA	NA	NA	-4.778	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.812	-3.292	2.48	4.27	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130C	130	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.812	-5.273	4.461	0.639	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130D	130	R	D	missense	wt-like	0.967356670060968	0.0905548583948895	2	0.0640319544404139	0.841856345498047	1.09285699462389	NA	0.903324715620554	NA	NA	NA	NA	NA	1.03138862450138	0.768411745125211	NA	0.724641014761525	NA	NA	NA	NA	NA	0.812182475488897	p.Arg130Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.812	-3.871	3.059	3.12	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130E	130	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.812	-3.399	2.587	6.638	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130F	130	R	F	missense	wt-like	1.08679256010431	0.0971852878612344	8	0.0343601880391228	1.01944782904561	1.15413729116302	1.14389465398452	0.957036801714808	1.11703327544585	1.08249624262003	1.07010443233754	1.16687731847284	1.21674819099573	0.940149565263195	0.810878595065905	0.851350931589181	0.749401382500255	0.841903499980905	0.770427676301301	0.779853690150906	0.866463701038752	0.942919808748317	0.766357835267146	p.Arg130Phe	0	0	NA	NA	NA	NA	NA	NA	NA	4.511	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.812	-4.459	3.647	1.318	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130G	130	R	G	missense	wt-like	1.08519791687069	0.0702895159953294	8	0.0248510967033088	1.03649066235588	1.13390517138549	1.05101099801126	0.986120780943916	1.01487615124981	1.12025119776292	1.21308123168643	1.08021424521798	1.10963379395394	1.10639493613923	0.815454454046333	0.807159069091273	0.76280860745433	0.791800286873919	0.786985170067401	0.833260933179827	0.823749839001393	0.885228702218403	0.849854249769163	p.Arg130Gly	1	0	no	NA	NA	NA	NA	NA	NA	-2.97	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.812	-3.591	2.779	3.24	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	167	3	51	3	0	0	31	1	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R130H	130	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.812	-4.48	3.668	1.968	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130I	130	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.812	-4.124	3.312	2.77	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130K	130	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.812	-2.612	1.8	20.557	20.557	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R130L	130	R	L	missense	wt-like	1.19384659313195	0.0942453691465281	7	0.0356214012830276	1.12402992953837	1.26366325672554	NA	1.1016474013436	1.1742641282306	1.33628836365362	1.08665479969498	1.18178017190632	1.30356286188151	1.17272842521304	0.873808910498942	NA	0.816064435196514	0.869972512650706	0.881728602126665	0.786035878419925	0.873808910498942	0.989677616893161	0.883170115768233	p.Arg130Leu	1	0	NA	NA	NA	NA	NA	NA	NA	-3.99	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.812	-2.894	2.082	9.038	9.038	64.27	0.000662631	0	0.01893909	0	NA	NA	Malignant melanoma of skin|Squamous cell carcinoma of the head and neck|Small cell lung cancer|Kidney cancer|Squamous cell carcinoma of lung|not provided|Neoplasm of breast|Glioblastoma|Renal cell carcinoma|Hereditary cancer-predisposing syndrome|Colorectal Neoplasms|Uterine cervical neoplasms|Adenocarcinoma of stomach|Malignant neoplasm of body of uterus|Adenocarcinoma of prostate|Uterine Carcinosarcoma	Pathogenic/Likely pathogenic(Last reviewed: May 31, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	24	0	8	0	0	0	2	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R130M	130	R	M	missense	wt-like	0.964812697532995	0.221108801062801	7	0.0835712714714035	0.801016015306825	1.12860937975917	NA	1.00889596486354	1.00381684609237	0.990627903551952	0.533238025523132	1.14658826269872	1.20843507948758	0.862086800513662	0.773307583944974	NA	0.773307583944974	0.786376223427743	0.73013867461491	0.579313778827012	0.856463779542139	0.938442421815685	0.727150963350329	p.Arg130Met	0	0	NA	NA	NA	NA	NA	NA	NA	-5.636	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.812	-4.628	3.816	1.388	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130N	130	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.812	-3.688	2.876	3.113	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130P	130	R	P	missense	wt-like	1.15629126640123	0.0844615069987636	6	0.0344812658422469	1.08870922720908	1.22387330559339	NA	1.02636438767772	1.21137068460349	1.1648707898572	1.272079607498	1.10864754046778	NA	1.15441458830321	0.846531446014939	NA	0.781360232876463	0.888171514592554	0.806553160948356	0.855299058313621	0.837763833716256	NA	0.873972026764688	p.Arg130Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.812	-4.072	3.26	2.012	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	Malignant melanoma of skin|Squamous cell carcinoma of the head and neck|Small cell lung cancer|Kidney cancer|Squamous cell carcinoma of lung|Neoplasm of breast|Glioblastoma|Renal cell carcinoma|Hereditary cancer-predisposing syndrome|Colorectal Neoplasms|Uterine cervical neoplasms|Adenocarcinoma of stomach|Malignant neoplasm of body of uterus|Adenocarcinoma of prostate|Uterine Carcinosarcoma	Likely pathogenic(Last reviewed: May 31, 2016)	criteria provided, single submitter	0	1	0	0	0	14	0	6	4	0	1	2	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R130Q	130	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.812	-2.77	1.958	13.749	13.749	64.27	0.000662631	0	0.01893909	0	NA	NA	Malignant melanoma of skin|Squamous cell carcinoma of the head and neck|Small cell lung cancer|Kidney cancer|PTEN hamartoma tumor syndrome|Squamous cell carcinoma of lung|Cowden syndrome 1|not provided|Neoplasm of breast|Glioblastoma|Renal cell carcinoma|Hereditary cancer-predisposing syndrome|Neoplasm|Ovarian Neoplasms|Colorectal Neoplasms|Uterine cervical neoplasms|Adenocarcinoma of stomach|Malignant neoplasm of body of uterus|Adenocarcinoma of prostate|Uterine Carcinosarcoma	Pathogenic/Likely pathogenic(Last reviewed: Nov 8, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	150	5	35	6	18	4	12	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.615	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
R130R	130	R	R	synonymous	possibly_wt-like	0.821333138771204	0.415744233681374	8	0.146987783437652	0.533242377066033	1.10942390047638	1.04480280145051	0.527301516939979	0.390953847518331	0.127653720911093	1.31196876797346	1.06608056536405	1.07351192260385	1.02839196740835	0.807441382614868	0.804205354943204	0.551300648474378	0.485796056703222	0.351680016796291	0.870199168663232	0.816783734192417	0.865773700970492	0.810677410286531	p.Arg130=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R130S	130	R	S	missense	possibly_wt-like	0.759755964221024	0.347792957029493	8	0.122963379182238	0.518752169606495	1.00075975883555	0.0305536837177599	0.920474892392921	0.763684951123987	0.508566477999384	1.01281309787411	0.975637177843615	1.09938418347766	0.766933249338758	0.705953617391514	0.321649440451911	0.732546957623674	0.668602944255379	0.5187298934826	0.758453209533953	0.772206658494001	0.879708329736205	0.679360277159354	p.Arg130Ser	0	0	NA	NA	NA	NA	NA	NA	NA	-1.786	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.812	-3.579	2.767	3.957	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130T	130	R	T	missense	possibly_wt-like	0.919097654261724	0.664679781732736	5	0.297253835044824	0.336490843307458	1.50170446521599	NA	1.13687768851902	1.19296800156036	1.38284424646739	-0.256207866703361	NA	NA	1.13900620146521	0.866233194414327	NA	0.832305004674185	0.879145873380487	0.902145756286877	0.284425875220776	NA	NA	0.866233194414327	p.Arg130Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.812	-3.636	2.824	2.994	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130V	130	R	V	missense	possibly_wt-like	0.837947088602966	0.516722089568392	8	0.182688846761346	0.47988352857357	1.19601064863236	1.16858608701267	0.799131174604427	0.404265365589424	0.521255976351899	1.47310398666373	-0.0586240830994011	1.23898915239864	1.15686904930234	0.769854040762702	0.863098535640971	0.676609545884433	0.492324723518604	0.524294892542234	0.930389268205952	0.262447528667274	0.954898643611401	0.8752047750324	p.Arg130Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.812	-3.867	3.055	2.47	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130W	130	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.812	-5.505	4.693	0.427	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R130X	130	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.219e-05	3	246154	NA	NA	NA	0	0	0	0	0	0	11	15	4	7	0	8	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R130Y	130	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg130Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	88.5	29.6	0.939	114.3	47.1	-64.9	-49.1	3.0188679245283	-2.1	1	0	21.93	1	40	0	0	6	5.09417096886235	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.812	-4.345	3.533	1.275	NA	64.27	0.000662631	0	0.01893909	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131A	131	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-0.933	-2.309	1.376	7.978	7.978	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	4	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T131C	131	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-0.933	-4.885	3.952	1.384	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131D	131	T	D	missense	possibly_wt-like	0.757561531738986	0.0452896522193659	2	0.032024620201894	0.6947944295247	0.820328633953272	NA	0.78958615194088	0.725536911537092	NA	NA	NA	NA	NA	0.661051297690901	NA	0.67220945107506	0.649893144306741	NA	NA	NA	NA	NA	p.Thr131Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-0.933	-3.821	2.888	1.339	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131E	131	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-0.933	-3.755	2.822	1.728	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131F	131	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-0.933	-4.259	3.326	2.882	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131G	131	T	G	missense	possibly_wt-like	0.724971195686952	0.469315728322695	6	0.191597343775543	0.349447302353349	1.10049508902056	0.928547083146442	0.751791079516676	0.940670731598149	0.994234033628921	-0.217612318879725	NA	NA	0.952196565111252	0.740306881254465	0.748893613990973	0.654786558761902	0.755406056087175	0.731720148517956	0.298842772310641	NA	NA	0.772408417533098	p.Thr131Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-0.933	-3.596	2.663	2.158	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131H	131	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-0.933	-4.975	4.042	0.66	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131I	131	T	I	missense	possibly_wt-like	0.72384315974061	0.541589648274504	4	0.270794824137252	0.193095057231739	1.25459126224948	NA	1.02125673236765	0.912362726258283	NA	NA	-0.0838791416981843	NA	1.0456323220347	0.760264007451277	NA	0.779005689738103	0.741522325164452	NA	NA	0.25	NA	0.81933634489901	p.Thr131Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-0.933	-2.698	1.765	17.451	17.451	64.27	0.000834554	0	0.023852955	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Dec 21, 2012)	no assertion criteria provided	1	0	0	0	0	1	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
T131K	131	T	K	missense	low	0.367281526072511	0.133922171967705	4	0.0669610859838525	0.23604020917847	0.498522842966552	NA	NA	0.521091004609264	NA	NA	0.372192558523812	0.381537161863038	0.194305379293931	0.483932976251939	NA	NA	0.549622145839719	NA	NA	0.474785285713771	0.493080666790107	0.391759042064976	p.Thr131Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-0.933	-3.765	2.832	1.97	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131L	131	T	L	missense	wt-like	1.1218054212048	0.163301649682372	5	0.0730307179055281	0.978667844344865	1.26494299806474	0.883150674753384	1.21580122884828	NA	NA	1.25902067086862	1.23046221301384	NA	1.02059231853989	0.850421051494048	0.727295068836996	0.868687428517598	NA	NA	0.850421051494048	0.897802959053496	NA	0.806760051797331	p.Thr131Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-0.933	-2.829	1.896	10.771	8.666	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T131M	131	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-0.933	-4.64	3.707	2.373	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131N	131	T	N	missense	low	0.418023575045054	0.0712605263693833	6	0.0290919880678558	0.361004326193388	0.475042823896721	0.470273065088321	0.362422274478455	0.523535760144914	0.381427588978585	0.335505240325289	NA	NA	0.434977521254762	0.509044630762706	0.530857596995486	0.475294092544551	0.550821182211986	0.462972937755239	0.505453103794853	NA	NA	0.512636157730558	p.Thr131Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-0.933	-3.838	2.905	1.242	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	1	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T131P	131	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-0.933	-3.985	3.052	1.267	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T131Q	131	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-0.933	-4.207	3.274	1.186	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131R	131	T	R	missense	low	0.258811363100666	0.185676743332095	8	0.0656466421593794	0.130146308762294	0.387476417439038	0.423642785291477	0.296434523444308	0.354376812376614	0.504018328952252	-0.0651859984294341	0.0634698059392772	0.252737825152492	0.240996822078341	0.434292522445992	0.508672004800295	0.444874849862557	0.467856759753062	0.516735295708344	0.355779768923834	0.322624272188316	0.423710195029427	0.415209728480368	p.Thr131Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-0.933	-4.042	3.109	1.609	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131S	131	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-0.933	-2.676	1.743	4.966	4.966	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	low	1.915	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
T131V	131	T	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-0.933	-2.658	1.725	19.975	19.975	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.445	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T131W	131	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-0.933	-5.433	4.5	0.362	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T131X	131	T	X	nonsense	low	-0.0856921283518925	0.0180619492919385	2	0.0127717268257773	-0.1107242529508	-0.0606600037529849	NA	NA	-0.0729204015261152	-0.0984638551776698	NA	NA	NA	NA	0.255401797177173	NA	NA	0.258287789045674	0.252515805308672	NA	NA	NA	NA	p.Thr131Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T131Y	131	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr131Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	92	30.8	0.891	110.6	56.6	-59.3	-37.7	0	-2.7	1	0	27.07	0	0	0	0	9	7.4983543434543	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-0.933	-4.39	3.457	1.576	NA	64.27	0.000834554	0	0.023852955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132A	132	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.708	-2.667	1.959	7.116	7.116	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	2	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G132C	132	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.708	-5.251	4.543	0.65	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G132D	132	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.708	-2.971	2.263	28.647	28.647	72.21	0.000473071	0	0.013521147	0	NA	NA	not specified|not provided	Conflicting interpretations of pathogenicity(Last reviewed: May 31, 2016)	criteria provided, conflicting interpretations	0	0	1	0	0	13	9	2	0	1	1	2	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G132E	132	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.708	-3.733	3.025	6.619	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132F	132	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.708	-4.476	3.768	2.294	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132H	132	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.708	-3.423	2.715	26.267	26.267	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132I	132	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.708	-4.366	3.658	1.663	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132K	132	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.708	-3.061	2.353	6.669	6.669	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132L	132	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.708	-3.936	3.228	2.794	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132M	132	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.708	-5.075	4.367	1.083	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132N	132	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.708	-3.663	2.955	5.009	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132P	132	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.708	-4.066	3.358	1.666	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132Q	132	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.708	-4.228	3.52	2.969	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132R	132	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.708	-4.053	3.345	3.512	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	1	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G132S	132	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.708	-2.847	2.139	3.775	3.547	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	0	1	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G132T	132	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.708	-3.788	3.08	2.553	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132V	132	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.708	-3.92	3.212	1.836	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	PTEN hamartoma tumor syndrome|not provided|Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic(Last reviewed: Mar 24, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	5	0	0	2	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
G132W	132	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.708	-5.377	4.669	0.429	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G132X	132	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G132Y	132	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly132Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	91.1	33.3	0.85	101.3	53	-63.1	-40.8	0	-4.6	1	0	28.29	0	0	0	0	9	9.01970165027646	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.708	-4.495	3.787	4.306	NA	72.21	0.000473071	0	0.013521147	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133A	133	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.503	-3.319	1.816	3.027	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V133C	133	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.503	-3.51	2.007	12.712	12.712	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.06	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V133D	133	V	D	missense	low	0.190712301038793	0.224946315818744	3	0.129872815991166	-0.0638337408746902	0.445258342952277	NA	0.15475531553282	0.431471327940117	NA	NA	-0.0140897403565574	NA	NA	0.379563119413946	NA	0.379563119413946	0.505667954743689	NA	NA	0.284397289971587	NA	NA	p.Val133Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.503	-4.182	2.679	1.544	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133E	133	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.503	-4.053	2.55	1.669	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V133F	133	V	F	missense	possibly_low	0.313306977426417	0.401275605263771	3	0.231676578718268	-0.140770772922848	0.767384727775681	NA	NA	NA	NA	-0.0648728000452582	NA	0.270540977055655	0.734252755268853	0.433298855017055	NA	NA	NA	NA	0.355896760367873	NA	0.433298855017055	0.662946562512068	p.Val133Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.503	-4.227	2.724	2.626	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133G	133	V	G	missense	low	0.365280688197905	0.150377287793144	7	0.0568372723332927	0.253881681445157	0.476679694950654	0.439094641934701	0.32917526235267	0.479824116445947	0.593715702239381	0.252442430440914	0.144692674146454	NA	0.318019989825268	0.474426002234586	0.516023635363926	0.459967779487115	0.529382698927126	0.556072217005594	0.474426002234586	0.362656805729764	NA	0.453894464822599	p.Val133Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.503	-3.957	2.454	1.78	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V133H	133	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.503	-5.214	3.711	0.606	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133I	133	V	I	missense	wt-like	1.07610643552333	0.0189453224578945	2	0.013396365981743	1.0498500406754	1.10236283037126	NA	1.06271006954159	1.08950280150507	NA	NA	NA	NA	NA	0.813258045890658	NA	0.798114980533907	0.828401111247409	NA	NA	NA	NA	NA	p.Val133Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.503	-2.413	0.91	15.901	15.901	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.365	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
V133K	133	V	K	missense	low	0.359912539535176	0.0521274510875347	6	0.0212809427927247	0.318202658104378	0.401622420965973	NA	0.337430696522639	0.394536668190388	0.279464898496653	0.381625020362659	0.339314845768469	0.427103107870246	NA	0.475663327814046	NA	0.463773395704155	0.487553259923937	0.418257042698821	0.522680586240349	0.45858075898754	0.517622184250289	NA	p.Val133Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.503	-4.016	2.513	1.911	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133L	133	V	L	missense	wt-like	1.14218685219868	0.149305680234877	3	0.0862016746751462	0.973234674428359	1.31113902996901	NA	NA	NA	NA	1.16517119392347	1.27866757134324	0.982721791329346	NA	0.816874736126591	NA	NA	NA	NA	0.815364721752632	0.921562063684924	0.816874736126591	NA	p.Val133Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.503	-1.904	0.401	13.884	13.884	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.31	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
V133M	133	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.503	-3.214	1.711	4.461	4.461	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133N	133	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.503	-4.245	2.742	1.821	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133P	133	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.503	-4.261	2.758	1.1	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133Q	133	V	Q	missense	low	0.567316432499174	0.0579867299694316	2	0.0410028099802183	0.486952401673006	0.647680463325341	NA	NA	NA	NA	NA	0.526313622518955	NA	0.608319242479392	0.575222024757442	NA	NA	NA	NA	NA	0.550747349108179	NA	0.599696700406705	p.Val133Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.503	-4.443	2.94	1.123	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133R	133	V	R	missense	possibly_low	0.269020732730467	0.39838108391225	2	0.281697965930799	-0.28309713501209	0.821138600473025	NA	-0.012677233200332	NA	NA	NA	NA	NA	0.550718698661267	0.436573235728903	NA	0.302379532263917	NA	NA	NA	NA	NA	0.570766939193889	p.Val133Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.503	-4.329	2.826	1.45	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133S	133	V	S	missense	possibly_low	0.640229691582565	0.104437440991449	3	0.0602969846698885	0.52204977325322	0.75840960991191	NA	0.575119218256237	0.584877882007908	0.76069197448355	NA	NA	NA	NA	0.580906576924532	NA	0.573343804030349	0.580906576924532	0.629299918543201	NA	NA	NA	NA	p.Val133Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.503	-3.725	2.222	3.827	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.365	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133T	133	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.503	-1.531	0.028	10.19	10.19	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V133W	133	V	W	missense	low	0.276793145363202	0.179133554201276	3	0.103422805739001	0.0740881709346775	0.479498119791726	NA	0.186640987656255	0.483093513907676	NA	NA	NA	NA	0.160644934525675	0.39426187764105	NA	0.39426187764105	0.530986182962583	NA	NA	NA	NA	0.374853149083521	p.Val133Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.503	-5.567	4.064	0.312	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V133X	133	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val133Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V133Y	133	V	Y	missense	low	0.561358161193508	0.0362134050313997	3	0.0209078191431516	0.520379588677654	0.602336733709362	NA	0.575771522957845	0.520157334404199	0.58814562621848	NA	NA	NA	NA	0.55362945158199	NA	0.57364450551979	0.549164224988637	0.55362945158199	NA	NA	NA	NA	p.Val133Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.2	88.3	35.1	0.948	113.7	43	-59.9	-50.5	0	-4	1	0	26.98	0	0	0	0	8	10.1973171893396	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.503	-4.409	2.906	1.192	NA	58.56	0.002983939	0	0.085285943	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134A	134	M	A	missense	possibly_wt-like	0.853777130180159	0.173869636306566	5	0.0777568652009295	0.701376474835602	1.00617778552472	0.856709326085865	0.838368277246605	1.02532120366325	0.972483151270231	0.57600369263484	NA	NA	NA	0.714714896014012	0.714714896014012	0.694697189859345	0.796923088549308	0.72218126553695	0.595288373216662	NA	NA	NA	p.Met134Ala	0	0	NA	NA	NA	NA	NA	NA	NA	2.661	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-1.496	-2.712	1.216	7.978	7.978	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
M134C	134	M	C	missense	possibly_wt-like	0.833447764240655	0.215978729846443	5	0.0965886243261418	0.644137539245148	1.02275798923616	NA	1.04302319065176	0.885748396560073	0.466789322240327	0.886824977164666	0.88485293458645	NA	NA	0.727461584311724	NA	0.789039660687186	0.728469261630575	0.50040845743724	0.711391880618156	0.727461584311724	NA	NA	p.Met134Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-1.496	-3.487	1.991	13.312	13.312	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M134D	134	M	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-1.496	-4.259	2.763	2.182	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134E	134	M	E	missense	low	0.194870682339622	0.0586136904298024	6	0.0239289389157449	0.147970823876503	0.241770540802741	NA	0.266625066044681	0.178975542930117	0.226350262307061	0.237464505371477	NA	0.113625041149006	0.146183676235391	0.388397156196815	NA	0.43113319168135	0.38183077525638	0.394963537137249	0.468831180641886	NA	0.348784968698868	0.367590010205948	p.Met134Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-1.496	-4.074	2.578	2.358	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134F	134	M	F	missense	possibly_wt-like	0.848084993794032	0.193379456502767	5	0.0864819220384304	0.678583541284908	1.01758644630316	1.00341093486359	NA	NA	NA	0.794114554433109	0.964927133069523	0.532726252668711	0.945246093935231	0.76692796991635	0.784512076749377	NA	NA	NA	0.676761030713229	0.76692796991635	0.574510112174814	0.768917556889946	p.Met134Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-1.496	-3.436	1.94	9.852	9.852	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134G	134	M	G	missense	low	0.563678267446083	0.0671886166583687	8	0.023754763228838	0.517119787056284	0.610236747835882	0.622605129070674	0.5762793175327	0.599968618721115	0.668996277920339	0.498137007889521	0.542285192359498	0.462872179004467	0.538282417070348	0.570040405612861	0.603333616107706	0.573878590272839	0.58830786590397	0.589086629493395	0.566202220952883	0.558619299698747	0.536887169632928	0.564520840928973	p.Met134Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-1.496	-3.925	2.429	2.515	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134H	134	M	H	missense	low	0.127233730500368	0.058706075221428	2	0.0415114638859193	0.045872756338431	0.208594704662305	0.0857222666144486	NA	NA	NA	NA	NA	NA	0.168745194386287	0.363409422816172	0.347897356772914	NA	NA	NA	NA	NA	NA	0.37892148885943	p.Met134His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-1.496	-5.151	3.655	0.856	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134I	134	M	I	missense	possibly_low	0.566351498808271	0.244989151075377	8	0.0866167450212674	0.396585798108498	0.736117199508044	0.436901700031253	0.527327843189813	0.756342397276685	0.869007503568724	0.124705024067115	0.695636760241222	0.736973625618152	0.383917136473209	0.592757441953147	0.514980285099042	0.551312784432493	0.665001770641144	0.676801860760107	0.426711248951836	0.634202099473802	0.684516397760152	0.486991178686106	p.Met134Ile	1	0	NA	NA	NA	NA	NA	NA	NA	2.931	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-1.496	-2.337	0.841	8.538	8.422	74.19	0.001894551	0	0.054149418	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Feb 29, 2016)	criteria provided, single submitter	0	1	0	0	0	8	1	2	1	0	1	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	deleterious	deleterious	low	1.88	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
M134K	134	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-1.496	-3.973	2.477	2.7	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M134L	134	M	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-1.496	-2.222	0.726	27.861	27.861	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.28	Deleterious	DAMAGING	effect	TOLERATED	null	D	D	D	D	D	D	0.857142857142857
M134N	134	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-1.496	-4.329	2.833	2.573	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134P	134	M	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-1.496	-4.295	2.799	1.555	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134Q	134	M	Q	missense	low	0.149169175536742	0.190035884481933	5	0.0849866311731797	-0.0174015607300795	0.315739911803563	0.186000177647057	NA	NA	NA	-0.0720789315712388	0.164966056359322	0.0338779718672777	0.433080603381291	0.372649002156084	0.395607232202519	NA	NA	NA	0.353204997652111	0.372649002156084	0.305833724081533	0.511683434414384	p.Met134Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-1.496	-4.312	2.816	1.588	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134R	134	M	R	missense	low	0.308214565928125	0.236403384138634	7	0.0893520805035568	0.13308770619743	0.48334142565882	0.365881762196665	0.452201928518024	0.22540592554736	0.243548662740144	0.723822086404207	-0.0192609730238515	NA	0.165902569114327	0.404602670738153	0.481190666306478	0.51668100210481	0.404602670738153	0.402505922153466	0.650504134907627	0.281848530616327	NA	0.377493785839907	p.Met134Arg	1	0	NA	NA	NA	NA	NA	NA	NA	9.876	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-1.496	-4.271	2.775	2.049	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M134S	134	M	S	missense	low	0.43817981544023	0.0808875288610055	4	0.0404437644305028	0.358911493757223	0.517448137123238	NA	0.338501032579035	0.409971523555908	0.521087233593527	NA	NA	NA	0.483159472032449	0.50967210644461	NA	0.46426680261287	0.495123322743737	0.524220890145483	NA	NA	NA	0.536835448889465	p.Met134Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-1.496	-3.269	1.773	5.512	5.512	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134T	134	M	T	missense	low	0.375403601026661	0.224104378683508	7	0.0847034933881724	0.209387804621117	0.541419397432206	0.444851325834962	0.238439895084597	0.54744068908288	0.517487548396521	0.498817105680773	-0.0781966538755708	0.458985296982466	NA	0.522642242654477	0.518762530390167	0.418140302212748	0.562545413471549	0.522642242654477	0.566456263204397	0.25280074305893	0.534793720656943	NA	p.Met134Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-1.496	-2.878	1.382	14.401	14.401	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
M134V	134	M	V	missense	possibly_wt-like	0.766332685924321	0.173535884229568	8	0.0613542002589654	0.646080663116491	0.886584708732151	0.591966948826656	0.727302177878278	0.918796877877228	1.06902083030625	0.57257570656825	0.857420826175689	0.761978170199007	0.631599949563215	0.670740633753797	0.588756689367014	0.643497587244015	0.744677970668999	0.764518013462699	0.594007890748234	0.713941047247393	0.697983680263578	0.611389390304341	p.Met134Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-1.496	-1.831	0.335	7.549	7.549	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.645	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
M134W	134	M	W	missense	possibly_low	0.62629988382651	0.115188330101102	5	0.0515137872641498	0.525334716081518	0.727265051571502	NA	0.51541974387639	0.645244524534518	0.790638741909076	0.663554712822612	NA	NA	0.516641695989954	0.610513545394591	NA	0.545823351057064	0.610513545394591	0.642433119551819	0.627991991103564	NA	NA	0.55365183081501	p.Met134Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-1.496	-5.446	3.95	0.549	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M134X	134	M	X	nonsense	low	0.0351624264989441	0.145839955936047	6	0.0595389126922163	-0.0815316980564745	0.151856551054363	-0.0091887611682894	-0.0252061758259158	-0.0493245361175729	-0.0497447716412136	0.328454096479334	NA	NA	0.0159847072673225	0.299400865796455	0.302740918373057	0.296603900570101	0.269860439336214	0.273881634479756	0.502819234840395	NA	NA	0.302197831022808	p.Met134Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M134Y	134	M	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met134Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.2	90.5	35.8	0.892	115.5	47.1	-65.5	-43	0	-3.7	1	0	23.75	0	0	0	0	7	11.9004872950649	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-1.496	-4.322	2.826	2.285	NA	74.19	0.001894551	0	0.054149418	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135A	135	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.358	-2.487	1.129	8.553	8.553	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135C	135	I	C	missense	possibly_low	0.364117985528364	0.372645287644565	4	0.186322643822282	-0.00106768586759365	0.729303656924322	0.580955511605317	0.400916434655012	NA	NA	-0.172611753965878	NA	NA	0.647211749819004	0.538278479322205	0.583517706098205	0.493039252546205	NA	NA	0.315652185570257	NA	NA	0.619230386648547	p.Ile135Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.358	-3.092	1.734	14.751	14.751	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I135D	135	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.358	-3.48	2.122	12.01	12.01	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135E	135	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.358	-4.064	2.706	5.272	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135F	135	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.358	-4.183	2.825	1.613	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135G	135	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.358	-3.929	2.571	3.24	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135H	135	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.358	-5.219	3.861	1.515	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135I	135	I	I	synonymous	wt-like	1.10766013851432	0.115609845228599	3	0.0667473752637026	0.976837686934884	1.23848259009376	NA	1.23847343231451	1.01919816820207	NA	NA	NA	NA	1.06530881502638	0.829218825271978	NA	0.879138932752346	0.793920030730409	NA	NA	NA	NA	0.829218825271978	p.Ile135=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	NA	NA	NA	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
I135K	135	I	K	missense	low	0.162758154658415	0.121309808728757	7	0.045850797927015	0.0728922420590418	0.252624067257788	0.0747421273704533	0.225120182178949	0.175495995381475	0.383096768662604	0.0378271981423215	NA	0.0546579004818574	0.188366910391244	0.388776457597251	0.342673264346812	0.412000138728139	0.380124222593337	0.463704959078217	0.394259094587494	NA	0.317025656338034	0.388776457597251	p.Ile135Lys	1	0	NA	NA	NA	NA	NA	NA	NA	16.064	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.358	-3.434	2.076	20.557	20.557	74.19	0.002212897	0	0.063248295	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jul 24, 2013)	criteria provided, single submitter	0	1	0	0	0	5	0	0	3	0	1	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I135L	135	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.358	-2.481	1.123	10.157	10.157	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.65	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
I135M	135	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.358	-3.671	2.313	4.019	4.019	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I135N	135	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.358	-4.353	2.995	3.113	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135P	135	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.358	-4.331	2.973	2.012	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135Q	135	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.358	-4.508	3.15	3.951	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135R	135	I	R	missense	low	0.149112796467381	0.146506861982744	7	0.0553743888815434	0.0405809885936412	0.257644604341122	0.12721584041914	0.137735319454515	0.169610394741587	0.367321964656631	-0.0775274956208377	NA	0.0402376215399411	0.279195930080695	0.371717187660875	0.367639024872753	0.371717187660875	0.377237615267185	0.456786894469166	0.351169752873372	NA	0.309258989376313	0.43439515625237	p.Ile135Arg	1	0	NA	NA	NA	NA	NA	NA	NA	14.122	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.358	-4.39	3.032	7.953	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I135S	135	I	S	missense	low	0.238312951627251	0.125300520904074	6	0.0511537234533196	0.138053495983623	0.33857240727088	NA	0.265317477644069	0.206824618264968	0.355358271456267	0.107830982881297	NA	0.0957894831227917	0.398756876394116	0.425469285849455	NA	0.430530415434804	0.395489422828104	0.451540198377624	0.420408156264106	NA	0.339178854987476	0.494444409227257	p.Ile135Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.358	-3.115	1.757	6.821	6.821	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135T	135	I	T	missense	possibly_wt-like	0.885711508449945	0.26738182813684	2	0.189067503841616	0.51514601027349	1.2562770066264	1.07477901229156	NA	NA	NA	NA	NA	NA	0.696644004608329	0.731262486376837	0.818467332185759	NA	NA	NA	NA	NA	NA	0.644057640567915	p.Ile135Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.358	-3.04	1.682	5.736	5.736	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I135V	135	I	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.358	-1.676	0.318	12.292	12.292	74.19	0.002212897	0	0.063248295	0	NA	NA	Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Nov 18, 2014)	criteria provided, single submitter	1	0	0	0	0	4	0	0	1	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.66	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I135W	135	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.358	-5.67	4.312	0.347	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I135X	135	I	X	nonsense	low	-0.0443524345632299	0.0455806894997863	3	0.0263160233525504	-0.0959308925505437	0.00722602342408379	NA	-0.0962943597477704	-0.0110243963720121	-0.0257385475699073	NA	NA	NA	NA	0.284409601044778	NA	0.26383344416491	0.288644837182191	0.284409601044778	NA	NA	NA	NA	p.Ile135Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I135Y	135	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile135Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	93.5	36.9	0.928	113.6	46.6	-66.5	-47.4	0	-5.2	1	0	28.01	0	0	0	0	7	13.4313252458572	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.358	-4.396	3.038	1.275	NA	74.19	0.002212897	0	0.063248295	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136A	136	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-1.458	-1.949	0.491	10.638	10.638	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.82	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
C136D	136	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-1.458	-4.034	2.576	2.152	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136E	136	C	E	missense	low	0.251714469395541	0.185617774689544	8	0.0656257935958666	0.123090277490783	0.380338661300298	0.396546194076048	0.190183277000959	0.314169371815124	0.499616453790442	-0.0987400059823823	0.190450562488245	0.371027946850287	0.150461955125604	0.422015867469645	0.495780082958857	0.395894813413791	0.448136921525499	0.514804846571933	0.343246077834543	0.385209619244747	0.487420473019799	0.369738767465714	p.Cys136Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-1.458	-3.997	2.539	3.354	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136F	136	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-1.458	-4.389	2.931	9.482	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	2	0	0	2	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C136G	136	C	G	missense	low	0.371881855807787	0.169977328724161	8	0.0600960608944146	0.254095740842008	0.489667970773565	0.343238014181309	0.4278580193899	0.477005033274207	0.705793911873269	0.157750114109516	0.348422729087184	0.217669009262639	0.297318015284272	0.466743544320344	0.470417302701798	0.505458869693999	0.52800007264402	0.605224288576208	0.4390548400998	0.463069785938891	0.40482236249474	0.443496938334032	p.Cys136Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-1.458	-3.126	1.668	15.182	15.182	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C136H	136	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-1.458	-5.053	3.595	3.403	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136I	136	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-1.458	-3.931	2.473	8.538	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136K	136	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-1.458	-3.933	2.475	7.762	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136L	136	C	L	missense	low	0.311681525366936	0.0714830540844128	4	0.0357415270422064	0.241629419611747	0.381733631122125	NA	NA	NA	NA	0.271671035911617	0.261265031344288	0.2973202772523	0.41646975695954	0.464665311459711	NA	NA	NA	NA	0.481608613750285	0.42011213699958	0.447722009169137	0.503340669074505	p.Cys136Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-1.458	-3.113	1.655	27.861	27.861	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C136M	136	C	M	missense	possibly_low	0.0317666964390435	0.494592137007253	2	0.349729453999375	-0.653690437732588	0.717223830610675	NA	NA	NA	NA	-0.317962757560331	NA	NA	0.381496150438418	0.373566665299656	NA	NA	NA	NA	0.261358087445121	NA	NA	0.485775243154192	p.Cys136Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-1.458	-4.832	3.374	3.698	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136N	136	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-1.458	-4.107	2.649	2.464	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136P	136	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-1.458	-4.236	2.778	1.279	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136Q	136	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-1.458	-4.381	2.923	3.095	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C136R	136	C	R	missense	low	0.167416316287957	0.149361406112343	8	0.0528072315547976	0.063916044317287	0.270916588258628	0.376498675485553	0.0993265153758859	0.171148922022536	0.329901590860313	-0.00700435636875185	0.00155994988914874	0.076904879660161	0.290994353378813	0.377752501433536	0.486241944352099	0.354011375383861	0.377992189760496	0.440376131868265	0.377512813106577	0.292110594900397	0.329007732335189	0.440320891429108	p.Cys136Arg	1	0	yes	0.118289028790768	-2.21486705663076	0.0875707592230725	0.149007298358464	NA	NA	16.561	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-1.458	-3.522	2.064	22.111	22.111	64.27	0.002731787	0	0.078079036	0	NA	NA	PTEN hamartoma tumor syndrome|Acute megakaryoblastic leukemia|not provided|Hereditary cancer-predisposing syndrome|Mediastinal germ cell tumor	Pathogenic(Last reviewed: Nov 26, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	11	3	2	5	0	1	5	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C136S	136	C	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-1.458	-1.906	0.448	9.659	9.659	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	low	0.945	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
C136T	136	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-1.458	-2.443	0.985	9.641	9.641	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.67	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C136V	136	C	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-1.458	-3.012	1.554	7.11	6.814	64.27	0.002731787	0	0.078079036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
C136W	136	C	W	missense	possibly_wt-like	0.8052655995941	0.23313170875533	6	0.0951756215522828	0.618724809145412	0.991806390042788	0.804199124804613	0.944417689873073	0.839885577322595	0.99386200966828	0.89879593301312	NA	NA	0.350433262882919	0.710919607233134	0.689731775243801	0.743584184315302	0.705975729005939	0.731556996836652	0.715863485460329	NA	NA	0.4701739682357	p.Cys136Trp	1	0	NA	0.498684046229918	-0.718011856344348	0.431240592890483	0.566127499569353	0.569682921	NA	22.339	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-1.458	-5.539	4.081	1.985	NA	64.27	0.002731787	0	0.078079036	0	NA	NA	Cowden syndrome	Likely pathogenic(Last reviewed: Nov 20, 2015)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C136X	136	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	0	0	1	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C136Y	136	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys136Tyr	1	0	NA	0.183363340323124	-1.77761445527172	0.137251731706432	0.229474948939817	NA	NA	NA	34.9	91.6	39.2	0.851	109.3	56.4	-62.5	-34.9	0	-4.3	1	0	29.29	0	0	0	0	9	14.7440590700119	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-1.458	-3.614	2.156	22.919	22.919	64.27	0.002731787	0	0.078079036	0	NA	NA	not provided|Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: May 27, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	15	5	0	1	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A137C	137	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.603	-1.85	0.247	24.105	24.105	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.195	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A137D	137	A	D	missense	low	0.211129983151334	0.103928991610918	3	0.0600034312831697	0.0935254188874974	0.328734547415171	NA	0.20189864323115	0.112124602789975	0.319366703432877	NA	NA	NA	NA	0.401295400081463	NA	0.401295400081463	0.349043567055252	0.435756040750525	NA	NA	NA	NA	p.Ala137Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.603	-4.1	2.497	2.674	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137E	137	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.603	-4.031	2.428	2.818	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A137F	137	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.603	-3.679	2.076	28.598	28.598	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137G	137	A	G	missense	low	0.472170920269495	0.174408497297372	6	0.0712019708640235	0.332617621747738	0.611724218791251	0.640552817910649	0.479553544411551	0.499923825616913	0.504549078874364	0.137379035413323	NA	NA	0.571067219390168	0.534265143749166	0.611872705025564	0.529289636716093	0.53924065078224	0.516968056904681	0.431445471617337	NA	NA	0.580986944192104	p.Ala137Gly	1	0	NA	NA	NA	NA	NA	NA	NA	4.436	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.603	-3.671	2.068	3.658	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A137H	137	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.603	-5.141	3.538	1.268	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137I	137	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.603	-2.805	1.202	7.816	7.816	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137K	137	A	K	missense	low	0.197874486897259	0.124451225319903	3	0.0718519484394245	0.0570472557369585	0.33870171805756	NA	0.285442353976767	0.252766837108893	NA	NA	NA	NA	0.0554142696061178	0.418021897185231	NA	0.439807644731385	0.418021897185231	NA	NA	NA	NA	0.322001252094473	p.Ala137Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.603	-4	2.397	2.959	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137L	137	A	L	missense	possibly_wt-like	0.719490246156301	0.244573436016066	6	0.0998466871464321	0.523794335373655	0.915186156938946	0.87988522615467	0.523146721083474	0.853018990940966	1.03275370697484	0.382837092819425	NA	NA	0.645299738964432	0.665343563482935	0.725741445070185	0.549385357507912	0.71241704405393	0.748613010630581	0.523133341152767	NA	NA	0.618270082911941	p.Ala137Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.603	-3.475	1.872	8.473	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137M	137	A	M	missense	low	0.497460793762825	0.0235144885303993	2	0.0166272542959786	0.464871974180918	0.530049613344732	0.480833539466846	NA	NA	NA	NA	NA	NA	0.514088048058803	0.544125644418111	0.535882022732807	NA	NA	NA	NA	NA	NA	0.552369266103415	p.Ala137Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.603	-3.226	1.623	4.582	4.582	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137N	137	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.603	-3.568	1.965	6.916	6.916	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137P	137	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.603	-3.571	1.968	11.908	11.908	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A137Q	137	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.603	-4.428	2.825	1.806	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137R	137	A	R	missense	low	0.204914887068711	0.20323278881036	8	0.0718536415636296	0.0640843374459468	0.345745436691475	0.119105563589162	0.115550287745094	0.236338508140773	0.526564779711157	-0.0805735501639139	0.203956642151942	0.0567856231815181	0.461591242193955	0.377823371327662	0.363780345595599	0.361490261407132	0.409964582790771	0.526623076437399	0.350031936276538	0.391866397059725	0.31817163372597	0.526002847360893	p.Ala137Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.603	-4.312	2.709	2.162	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137S	137	A	S	missense	wt-like	1.08352574925443	0.0845913191391451	4	0.0422956595695726	1.00062777979571	1.16642371871316	NA	1.14299600854466	1.04170404474317	1.16421563658187	NA	NA	NA	0.985187307148034	0.805611967883363	NA	0.835125447237378	0.804958093296993	0.806265842469733	NA	NA	NA	0.788977953618926	p.Ala137Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.603	-2.131	0.528	12.006	12.006	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	0.6	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
A137T	137	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.603	-2.506	0.903	7.506	7.506	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.125	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A137V	137	A	V	missense	wt-like	0.880491750625221	0.0134246379061983	2	0.00949265249844677	0.861886493610511	0.899097007639931	NA	NA	NA	NA	0.870999098126774	NA	0.889984403123668	NA	0.736203653853732	NA	NA	NA	NA	0.705480316142157	NA	0.766926991565307	NA	p.Ala137Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.603	-2.673	1.07	7.75	7.75	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A137W	137	A	W	missense	possibly_low	0.499914929135809	0.309158081855921	2	0.218607776138947	0.0714515611630783	0.92837829710854	NA	NA	NA	NA	0.718522705274757	NA	NA	0.281307152996862	0.541990064726318	NA	NA	NA	NA	0.648524615592799	NA	NA	0.435455513859836	p.Ala137Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.603	-5.643	4.04	1.329	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A137X	137	A	X	nonsense	low	-0.0951794442010584	0.116336973821216	7	0.043971243001824	-0.181361496840092	-0.00899739156202453	-0.0775448785527954	-0.0946491142637919	0.0264273146542565	-0.0756638373850806	-0.34279296444237	NA	-0.0670195578760819	-0.0350130715415459	0.264591874644269	0.2702186828011	0.264591874644269	0.307013121073675	0.262514788251149	0.252083065907036	NA	0.251490981203021	0.276584295706491	p.Ala137Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A137Y	137	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala137Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	89.9	40.6	0.91	110	45.9	-60.4	-42.2	0	-4.1	1	0	25.83	0	0	0	0	9	16.0368936474618	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.603	-4.528	2.925	6.633	NA	74.19	0.003281004	0	0.093776558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138A	138	Y	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.479	-3.176	1.697	8.769	8.769	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138C	138	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.479	-2.706	1.227	16.909	16.909	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138D	138	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.479	-4.38	2.901	1.361	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138E	138	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.479	-4.208	2.729	1.434	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138F	138	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.479	-2.156	0.677	15.112	15.112	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138G	138	Y	G	missense	low	0.247884867375908	0.174433242817377	6	0.0712120731802622	0.108311768678164	0.387457966073653	NA	0.364572739020923	0.261495283496218	0.453211942602948	-0.0403977393302608	NA	0.14692590696393	0.30150107150169	0.43395032769983	NA	0.476285420507259	0.422302785208252	0.49445407667172	0.365039121378234	NA	0.366720595004243	0.445597870191408	p.Tyr138Gly	0	0	NA	NA	NA	NA	NA	NA	NA	10.027	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.479	-3.958	2.479	2.372	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138H	138	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.479	-4.712	3.233	0.67	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138I	138	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.479	-3.805	2.326	5.54	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138K	138	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.479	-4.167	2.688	1.506	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138L	138	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.479	-1.939	0.46	18.077	18.077	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y138M	138	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.479	-4.693	3.214	2.399	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138N	138	Y	N	missense	low	0.308298958306027	0.142122068256174	3	0.0820542143654883	0.147475653369941	0.469122263242114	0.144262857477157	0.38609794436235	0.394536073078576	NA	NA	NA	NA	NA	0.486208177909944	0.375749595305556	0.486208177909944	0.487552968049883	NA	NA	NA	NA	NA	p.Tyr138Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.479	-4.453	2.974	1.528	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138P	138	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.479	-4.554	3.075	0.88	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138Q	138	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.479	-4.493	3.014	0.919	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138R	138	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.479	-4.431	2.952	1.178	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138S	138	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.479	-3.425	1.946	6.112	6.112	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y138T	138	Y	T	missense	low	0.256906822601402	0.0904310033761097	4	0.0452155016880548	0.168286067749905	0.3455275774529	NA	0.18302992392575	0.260538318298415	0.383120431639402	NA	NA	NA	0.200938616542043	0.408462005927426	NA	0.392597238033897	0.42183343927062	0.463715336513161	NA	NA	NA	0.395090572584233	p.Tyr138Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.479	-3.952	2.473	2.283	NA	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138V	138	Y	V	missense	possibly_low	0.566263487429785	0.30055338632822	6	0.122700406161621	0.325775110464572	0.806751864394999	NA	0.374238347728166	0.71605520494151	NA	0.405657402425691	0.30901449693761	0.484427625690995	1.10818784685474	0.540077190413883	NA	0.480741103453366	0.645242817959802	NA	0.53165759002872	0.443646544551835	0.548496790799045	0.850754735692341	p.Tyr138Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.479	-3.222	1.743	5.545	5.545	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.94	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138W	138	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.479	-2.279	0.8	15.894	15.894	31.27	0.002471238	0	0.070632088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y138X	138	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr138Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	93.4	41.4	0.907	105	59.2	-65.6	-46.3	3.92156862745098	-6.2	1	0	31.22	0	0	0	0	9	17.876620426132	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L139A	139	L	A	missense	possibly_low	0.541386323042334	0.279259754808816	7	0.105550266059	0.334511603008073	0.748261043076594	0.388346572849913	0.451103078527312	0.867232817991673	0.838622318010339	0.137849789748729	0.354913741930785	NA	0.751635942237584	0.516174450752252	0.49187889571592	0.516174450752252	0.71938825053015	0.663476390803631	0.431621316169127	0.466269028899834	NA	0.671677234390983	p.Leu139Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-0.96	-3.384	2.424	2.757	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139C	139	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-0.96	-4.953	3.993	0.775	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.605	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139D	139	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-0.96	-4.344	3.384	0.954	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139E	139	L	E	missense	low	0.585559283034356	0.0612111117728325	7	0.0231356256035275	0.540214290091639	0.630904275977073	0.52146970733504	NA	0.65262777477345	0.641256349442735	0.519934028268999	0.648624733980544	0.536117276810204	0.578885110629519	0.576921241106582	0.55521575722093	NA	0.614134678654309	0.576921241106582	0.574344232594034	0.611031155629126	0.576336495372547	0.584913464876637	p.Leu139Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-0.96	-4.125	3.165	1.396	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139F	139	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-0.96	-2.639	1.679	11.286	11.286	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.26	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L139G	139	L	G	missense	low	0.421657890728864	0.155238949083315	8	0.0548852568005427	0.314084764117568	0.529231017340159	0.535689074863575	0.336874121518542	0.489376519018142	0.664576992199153	0.196955816185986	0.32186119433563	0.524278449759128	0.303650957950753	0.498792261142025	0.561980998404041	0.463516823994178	0.534067698289873	0.587148544929337	0.453699652883782	0.449978330855802	0.569960181343291	0.446677646483147	p.Leu139Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-0.96	-4.022	3.062	1.506	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139H	139	L	H	missense	low	-0.0295514822470026	0.30676999654992	4	0.15338499827496	-0.330180554634663	0.271077590140658	-0.0860947640923803	NA	0.389465870949982	NA	-0.348369550675429	-0.0732074851701832	NA	NA	0.260705308040982	0.266150848022428	NA	0.48506627493138	NA	0.25	0.255259768059536	NA	NA	p.Leu139His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-0.96	-5.1	4.14	0.786	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139I	139	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-0.96	-2.691	1.731	10.107	10.107	51.12	0.002316912	0	0.06622121	3.231e-05	1	30952	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.57	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L139K	139	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-0.96	-3.954	2.994	1.868	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139L	139	L	L	synonymous	wt-like	0.964523046921421	0.125089740360919	5	0.0559418325469626	0.854879069900204	1.07416702394264	0.980475253510017	1.13084044216612	0.794733947958568	1.01198383884504	NA	NA	NA	0.904581752127362	0.748493970229158	0.773599818117302	0.82952193570969	0.683831001205924	0.739504352951602	NA	NA	NA	0.748493970229158	p.Leu139=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L139M	139	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-0.96	-2.067	1.107	8.32	8.32	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.515	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L139N	139	L	N	missense	possibly_low	0.622568261238497	0.253698253911417	8	0.0896958778579749	0.446767571075162	0.798368951401831	0.904114948346682	0.514485208697798	0.815373832089134	0.716811864827346	0.928056859681673	0.250696300637474	0.471613464784858	0.379393610843009	0.577724387446354	0.737269377947635	0.545392546067548	0.693953883200065	0.610056228825159	0.726793548442264	0.4149030982664	0.541595168399594	0.484719246727704	p.Leu139Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-0.96	-4.367	3.407	1.088	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139P	139	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-0.96	-4.357	3.397	0.839	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139Q	139	L	Q	missense	low	0.221550247497804	0.288297740338483	5	0.128930669031286	-0.0311492203061706	0.474249715301779	0.460337209798055	0.197035914374937	0.416592537865327	0.293507443637891	-0.259721868187189	NA	NA	NA	0.424415422512973	0.526130350353591	0.39905376391633	0.498370615514946	0.424415422512973	0.283113262740252	NA	NA	NA	p.Leu139Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-0.96	-4.333	3.373	1.521	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139R	139	L	R	missense	low	0.273891270516033	0.105828671918482	5	0.0473280208756499	0.181130054140199	0.366652486891866	0.323197198306007	0.166936254767368	0.273836732155464	0.423704904246168	NA	NA	NA	0.181781263105156	0.428355679091957	0.460882353089541	0.385178327401238	0.428355679091957	0.481513719523914	NA	NA	NA	0.385468829043952	p.Leu139Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-0.96	-4.213	3.253	1.651	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139S	139	L	S	missense	low	0.20670721077257	0.325939921000987	3	0.188181501129565	-0.162121753998062	0.575536175543201	NA	0.0341505528914974	0.00332197285007113	NA	NA	NA	NA	0.58264910657614	0.323966353561262	NA	0.323966353561262	0.295681049292725	NA	NA	NA	NA	0.586803924527254	p.Leu139Ser	1	0	NA	NA	NA	NA	NA	NA	NA	6.444	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-0.96	-3.855	2.895	1.759	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L139T	139	L	T	missense	possibly_low	0.495760733871807	0.317018338332054	7	0.119821669181936	0.26091457770774	0.730606890035874	0.598261700931351	0.309290995517113	0.499473009062101	0.485960026338592	1.05858766336568	0.00532198374566994	NA	0.513429758142144	0.539019546692871	0.59175158461047	0.450801467119365	0.539019546692871	0.508815799265549	0.775551741287948	0.293964798647069	NA	0.552038641271853	p.Leu139Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-0.96	-3.727	2.767	2.075	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139V	139	L	V	missense	low	0.462416143165834	0.116276541776101	8	0.0411099655914009	0.381842091201007	0.54299019513066	0.60383272637085	0.471355909178484	0.461666590382641	0.601462639813848	0.248566497884224	0.403937904778424	0.399737637802598	0.5087692391156	0.522993980197852	0.594402147700553	0.525510664836234	0.52047729555947	0.559469648418507	0.472978194807357	0.49043169991674	0.502883322878575	0.54969790464632	p.Leu139Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-0.96	-2.768	1.808	6.561	6.48	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L139W	139	L	W	missense	possibly_wt-like	0.78130821954504	0.248181683644519	6	0.101319748072318	0.582725162400625	0.979891276689456	NA	0.693712925375657	0.699920915233291	0.77753229723964	1.18821088777977	NA	0.439872454772825	0.888599836869062	0.637007491943341	NA	0.628013507132613	0.637329715844383	0.6366852680423	0.823970918944756	NA	0.524499670123516	0.740467084344087	p.Leu139Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-0.96	-5.276	4.316	0.524	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L139X	139	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L139Y	139	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu139Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36	94.5	42.9	0.864	111.4	43.2	-51.4	-36.3	1.57068062827225	-6.2	1	0	34.09	0	0	0	0	8	19.183715955466	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-0.96	-4.107	3.147	2.618	NA	51.12	0.002316912	0	0.06622121	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.605	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140A	140	L	A	missense	low	0.230269954195939	0.201121064193774	7	0.0760166170390546	0.081280122572818	0.37925978581906	NA	0.338910325802556	0.459538149455419	0.444635358283428	-0.0755860826878571	0.0397292710123988	0.180375329856776	0.22428732764885	0.406817417370278	NA	0.464455479900688	0.51943339646578	0.490692802400107	0.351894944042872	0.310923210877258	0.384736233170252	0.406817417370278	p.Leu140Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.516	-3.152	1.636	6.325	6.325	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L140C	140	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.516	-5.167	3.651	0.881	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L140D	140	L	D	missense	low	0.143690008810837	0.136068752300194	4	0.0680343761500972	0.010345081845996	0.277034935775679	NA	0.0972827851747848	0.0975316808485876	0.343230253824981	NA	NA	NA	0.0367153153949959	0.347477841356335	NA	0.353069250156231	0.341886432556439	0.446221437553643	NA	NA	NA	0.312609738674648	p.Leu140Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.516	-4.269	2.753	2.192	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140E	140	L	E	missense	low	0.25266022017063	0.189163111109892	6	0.077225516729439	0.101300988693434	0.404019451647826	NA	0.0947385373583325	0.245675696729653	0.510791904942258	0.393409920969818	-0.00594434291905225	NA	0.277289603942769	0.423990868789563	NA	0.351896394731415	0.414544029925471	0.51970585789824	0.527082692411871	0.288411933917595	NA	0.433437707653654	p.Leu140Glu	0	0	NA	NA	NA	NA	NA	NA	NA	8.321	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.516	-4.076	2.56	2.563	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140F	140	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.516	-3.573	2.057	6.982	6.982	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.045	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L140G	140	L	G	missense	low	0.333353603159088	0.351900568061221	7	0.133005912758907	0.0726668044207534	0.594040401897422	NA	0.27182827489574	0.216123041699034	0.326944061639689	-0.0112995300477221	1.09011403626444	0.155807850014996	0.283957487647434	0.433531783393978	NA	0.433531783393978	0.400049857497173	0.439079102870397	0.375908403261281	0.828629175644736	0.371504350847556	0.436786639288395	p.Leu140Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.516	-4.027	2.511	1.711	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140H	140	L	H	missense	low	0.227702847704174	0.024172696384135	2	0.0170926775327854	0.194201815340558	0.261203880067791	0.210610170171389	NA	NA	NA	NA	NA	NA	0.24479552523696	0.41221685426784	0.407316088774906	NA	NA	NA	NA	NA	NA	0.417117619760773	p.Leu140His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.516	-3.461	1.945	8.609	8.609	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.945	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L140I	140	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.516	-1.928	0.412	14.823	14.823	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.49	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
L140K	140	L	K	missense	low	0.132760093697451	0.263567801822337	5	0.117871104310988	-0.0982630255700483	0.363783212964951	0.135787123426358	0.466923336785737	0.0113371979718115	0.278032886971408	-0.228280076668059	NA	NA	NA	0.371717040064088	0.371717040064088	0.523467323561417	0.29961213618985	0.417629031837399	0.294857961240805	NA	NA	NA	p.Leu140Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.516	-4.034	2.518	3.117	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140L	140	L	L	synonymous	possibly_wt-like	0.902687355560912	0.430790715994974	8	0.152307518276127	0.604170105165027	1.2012046059568	0.103889408497798	1.11526130515645	1.22179503193894	1.12062022319444	0.722957861334553	1.34715812687727	0.46827052999182	1.12154635749602	0.804743611238691	0.356540856295802	0.822340215738241	0.893284161411461	0.787147006739141	0.650181314152534	0.955319188029449	0.539794685807208	0.857464021705878	p.Leu140=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L140M	140	L	M	missense	possibly_low	0.64533344885056	0.774722856365442	3	0.447286449669944	-0.231331883275317	1.52199878097644	NA	NA	NA	NA	-0.243734302658392	1.17568343087385	NA	1.00405121833622	0.798452316359963	NA	NA	NA	NA	0.28908522323682	0.870803993346138	NA	0.798452316359963	p.Leu140Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.516	-2.641	1.125	5.989	5.989	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.185	Neutral	TOLERATED	neutral	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L140N	140	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.516	-3.251	1.735	8.331	8.331	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140P	140	L	P	missense	low	0.234020469830637	0.146292968671243	6	0.0597238543669185	0.116963866253562	0.351077073407713	NA	0.47325592486819	0.17702287930374	0.281721728860211	0.134544115157203	0.0551127623171607	NA	0.282465408477319	0.424816650398195	NA	0.526386540092763	0.380873086572711	0.419246779133001	0.430386521663388	0.318505313617974	NA	0.436037245424366	p.Leu140Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.516	-4.431	2.915	0.809	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140Q	140	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.516	-3.154	1.638	5.308	5.308	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140R	140	L	R	missense	low	0.159983223079769	0.154831276110548	4	0.077415638055274	0.00825136065124391	0.311715085508295	NA	0.316417344926068	0.176319649585838	NA	NA	-0.0533958062347333	NA	0.200591704041905	0.38772226114054	NA	0.454086594263576	0.380528185825979	NA	NA	0.265024403549541	NA	0.394916336455101	p.Leu140Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.516	-3.657	2.141	8.878	8.878	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140S	140	L	S	missense	low	0.194206736522527	0.147385180758508	7	0.0557063621747592	0.085024272950255	0.3033892000948	0.208256222478995	0.165386145076155	0.142412203500739	0.275734498382591	-0.0566483673622363	NA	0.433037164129986	0.191269289451462	0.390234171840823	0.406196135736242	0.384463752921251	0.363898195402059	0.416621069979482	0.358968897085701	NA	0.520818227744812	0.390234171840823	p.Leu140Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.516	-3.255	1.739	5.075	5.075	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L140T	140	L	T	missense	low	0.265089008820914	0.114207934995398	7	0.0431665419640078	0.180484141234322	0.349693876407506	0.23319748852468	0.369165833211215	0.31382554280758	0.425480890712858	0.213355322675517	NA	0.0821778340949844	0.218420149719567	0.447968289742127	0.418062604471408	0.478402759629234	0.447968289742127	0.482292581126042	0.45982548891193	NA	0.331847710754786	0.403870638655424	p.Leu140Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.516	-3.369	1.853	5.614	5.614	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140V	140	L	V	missense	possibly_low	0.634695177868406	0.163006709205261	8	0.0576315747289718	0.521739367027292	0.747650988709519	0.592063212534728	0.814763651271943	0.754941450939021	0.870119725811128	0.467786351546447	0.426704255561023	0.532192130313894	0.618990644969062	0.596929440475587	0.588802489378934	0.68381585454047	0.664314673060238	0.677289627538678	0.554865102715634	0.501652612468068	0.574222437403516	0.60505639157224	p.Leu140Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.516	-2.097	0.581	12.292	12.292	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.8	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
L140W	140	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.516	-5.572	4.056	0.648	NA	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L140X	140	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	4	3	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L140Y	140	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu140Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	91.6	45.4	0.857	115.3	47.7	-77.2	-39.8	6.80628272251309	-2.2	1	0	34.69	0	0	0	0	9	20.822056523312	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.516	-3.434	1.918	7.482	7.482	28.04	0.003119933	0	0.089172895	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141A	141	H	A	missense	possibly_low	0.450295914446768	0.208384811588345	2	0.147350313370399	0.161494607130095	0.739097221763442	NA	NA	0.302945601076369	0.597646227817168	NA	NA	NA	NA	0.50021407529274	NA	NA	0.442632195529996	0.557795955055484	NA	NA	NA	NA	p.His141Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.191	-2.52	0.329	8.841	8.841	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.26	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H141C	141	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Cys	0	0	NA	NA	NA	NA	NA	NA	NA	4.579	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.191	-5.391	3.2	0.695	NA	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141D	141	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.191	-2.616	0.425	12.502	12.502	74.19	0.003198906	0	0.091430058	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Nov 4, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H141E	141	H	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.191	-2.92	0.729	8.551	8.551	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141F	141	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.191	-2.459	0.268	14.825	14.825	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.86	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H141G	141	H	G	missense	low	0.516471991770016	0.120664540407871	8	0.042661357385582	0.432857267762684	0.600086715777349	0.666139537600213	0.480628230957346	0.490876563072579	0.544950126230475	0.565807906506621	0.300392823186808	0.656364567965606	0.426616178640484	0.534744698539522	0.624046265448501	0.529785049127203	0.534803398589982	0.534685998489063	0.591479861415444	0.439397157018117	0.641100891901548	0.508436689648914	p.His141Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.191	-3.414	1.223	13.537	13.537	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141I	141	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.191	-3.625	1.434	6.94	6.94	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141K	141	H	K	missense	possibly_low	0.578312413434282	0.406834218387375	7	0.153768880954905	0.276930944819641	0.879693882048923	NA	0.513275809756346	0.685276019264758	0.771690087940279	1.33572306280248	0.13528288387325	0.206013636825252	0.400925393577608	0.54483503350919	NA	0.54483503350919	0.63014709055598	0.634123158150014	0.879072296350319	0.358018977085629	0.398544855908312	0.495533542769163	p.His141Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.191	-3.997	1.806	4.226	NA	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.49	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H141L	141	H	L	missense	low	0.300202898003375	0.0416881594100353	3	0.0240686700574039	0.253029171535086	0.347376624471664	NA	0.292755800645334	0.262740184522527	0.345112708842264	NA	NA	NA	NA	0.443179020563512	NA	0.443179020563512	0.422913349981968	0.447046991102724	NA	NA	NA	NA	p.His141Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.191	-2.982	0.791	10.809	10.809	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.01	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H141M	141	H	M	missense	possibly_low	0.523999299108842	0.266930185334434	8	0.0943740720766799	0.339029516764162	0.708969081453521	0.826994690699817	0.454011282345341	0.730849773222337	0.634083672027715	0.488635588026448	-0.0596418629044534	0.520587072406646	0.596474177046882	0.570873841131117	0.700577370230856	0.517515083768576	0.652498850402314	0.573775652371648	0.56265308121792	0.261945892796947	0.567972029890587	0.593747539308597	p.His141Met	0	0	NA	NA	NA	NA	NA	NA	NA	4.578	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.191	-4.998	2.807	1.435	NA	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.355	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H141N	141	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.191	-3.268	1.077	8.724	8.724	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
H141P	141	H	P	missense	low	0.133314163298692	0.127095827804144	4	0.0635479139020721	0.00876254075797885	0.257865785839406	NA	-0.0278137097022118	0.191709048309425	0.267779576876874	NA	NA	NA	0.101581737710683	0.366632363784414	NA	0.295401871336774	0.388075954323815	0.413132426892972	NA	NA	NA	0.345188773245013	p.His141Pro	1	0	NA	NA	NA	NA	NA	NA	NA	29.267	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.191	-3.756	1.565	36.706	36.706	74.19	0.003198906	0	0.091430058	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: May 12, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H141Q	141	H	Q	missense	possibly_low	0.703493586167595	0.0609605794841659	2	0.0431056391383152	0.619008085925917	0.787979086409273	NA	0.66038794702928	NA	NA	NA	NA	NA	0.74659922530591	0.640899403029093	NA	0.612651252959622	NA	NA	NA	NA	NA	0.669147553098564	p.His141Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.191	-4.336	2.145	1.875	NA	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H141R	141	H	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.191	-3.057	0.866	12.037	12.037	74.19	0.003198906	0	0.091430058	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Feb 17, 2017)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H141S	141	H	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.191	-3.042	0.851	6.767	6.767	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.995	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
H141T	141	H	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.191	-3.348	1.157	6.529	6.529	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141V	141	H	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.191	-3.175	0.984	7.95	7.95	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H141W	141	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.191	-3.838	1.647	12.814	12.814	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H141X	141	H	X	nonsense	low	0.0396968918359985	0.0832243208263667	2	0.0588484816159687	-0.0756440126761676	0.155037796348165	0.0985453734519672	NA	NA	NA	NA	-0.0191515897799702	NA	NA	0.317950366267505	0.353998289905033	NA	NA	NA	NA	0.281902442629978	NA	NA	p.His141Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H141Y	141	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His141Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40	92.3	46	0.917	113	47.4	-67.9	-44.4	21.7592592592593	-2.4	1	0	37.64	0	0	0	0	6	22.0652984992272	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.191	-1.896	-0.295	13.94	13.94	74.19	0.003198906	0	0.091430058	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	-0.05	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
R142A	142	R	A	missense	wt-like	1.07420089431304	0.286218786362854	3	0.165248493353721	0.750319798840243	1.39808198978584	NA	1.37207297810227	NA	NA	0.801267433327048	1.04926227150982	NA	NA	0.80849445645955	NA	0.940726074939065	NA	NA	0.679432901556504	0.80849445645955	NA	NA	p.Arg142Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.671	-2.704	0.033	13.081	13.081	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142C	142	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.671	-2.698	0.027	22.906	22.906	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.47	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R142D	142	R	D	missense	possibly_wt-like	0.755040846600374	0.211732604449886	7	0.0800274022597725	0.598190020394921	0.911891672805828	1.07118730416648	0.799707284542478	0.747578234648936	0.726849000009253	0.385623785472545	0.897048540099301	0.657291777263632	NA	0.660703365500062	0.816758481797247	0.676875122870199	0.660703365500062	0.614458029928483	0.52417427627266	0.733472465206821	0.641600280703289	NA	p.Arg142Asp	0	0	NA	NA	NA	NA	NA	NA	NA	2.045	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.671	-3.461	0.79	15.751	15.751	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142E	142	R	E	missense	possibly_low	0.64954895113798	0.157852262230089	3	0.0911360460907332	0.47092558310676	0.828172319169199	NA	NA	NA	NA	0.559646054728615	0.831815506319506	0.557185292365819	NA	0.589178176688168	NA	NA	NA	NA	0.589178176688168	0.701320884371988	0.587683589352066	NA	p.Arg142Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.671	-3.415	0.744	8.996	8.182	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.365	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142F	142	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.671	-3.506	0.835	11.765	11.765	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.3	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R142G	142	R	G	missense	wt-like	0.94448946169368	0.094799397767372	8	0.0335166485068548	0.878798037737756	1.0101808856496	1.05159934143129	0.844222418605985	0.919599079420116	0.970543880991445	1.08464642833052	0.803438840050147	0.957050520538111	0.924815184181832	0.751863792277629	0.807438989075547	0.697395850503401	0.745071412390997	0.721330795567373	0.785285675743389	0.687334800535044	0.803048359291389	0.758656172164261	p.Arg142Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.671	-3.054	0.383	12.652	12.652	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.1	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R142H	142	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.671	-5.118	2.447	2.667	NA	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R142I	142	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.671	-2.634	-0.037	14.823	14.823	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.125	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R142K	142	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.671	-3.254	0.583	14.094	14.094	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R142L	142	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.671	-2.493	-0.178	14.722	14.722	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.45	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
R142M	142	R	M	missense	wt-like	0.927236830512698	0.289230199765249	7	0.109318740032626	0.712976037213454	1.14149762381194	0.353679432301277	0.957872674694002	1.01960227237449	0.986285583417071	1.29116947127725	NA	1.05758474722462	0.824463632300166	0.74978670587629	0.475385084266874	0.74978670587629	0.794118224616813	0.728234343427346	0.862429844559293	NA	0.857195429543868	0.708254800218209	p.Arg142Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.671	-2.922	0.251	5.024	5.024	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.495	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R142N	142	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.671	-2.876	0.205	13.203	13.203	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142P	142	R	P	missense	low	0.193655578382884	0.126015539079356	6	0.0514456284010294	0.0928239995548353	0.294487157210932	NA	0.205249546419911	0.270349023062224	0.401927265881128	0.114421086779086	0.0774738768716836	0.0925126712832696	NA	0.412854959707569	NA	0.402840110057259	0.42664512357927	0.471963102655086	0.42286980935788	0.329526496299491	0.337413985780971	NA	p.Arg142Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.671	-3.596	0.925	15.591	15.591	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.3	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R142Q	142	R	Q	missense	wt-like	1.05805008798212	0.191051409069187	4	0.0955257045345935	0.870823147496505	1.24527702846774	NA	1.06596785371748	0.933298796323955	1.32509488183531	NA	0.907838820051743	NA	NA	0.775703618245849	NA	0.799616764211924	0.751790472279774	0.876819683423778	NA	0.738790699512656	NA	NA	p.Arg142Gln	1	0	NA	NA	NA	NA	NA	NA	NA	-3.29	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.671	-3.465	0.794	18.633	18.633	87.1	0.00313499	0	0.08960323	4.062e-06	1	246164	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Dec 20, 2015)	criteria provided, single submitter	0	0	1	0	0	5	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
R142R	142	R	R	synonymous	wt-like	0.924970743188951	0.253992091158166	8	0.0897997650128455	0.748966437943614	1.10097504843429	0.636453877114841	1.07801054373207	1.13296418448141	0.857710125210816	1.27775461993546	0.966551866412425	0.5117340032755	0.938586725349089	0.766650829283255	0.609922525242723	0.805168241635484	0.849716853544629	0.671847378069653	0.857418890131229	0.767728756609572	0.56320382534977	0.765572901956938	p.Arg142=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R142S	142	R	S	missense	possibly_wt-like	0.871550932689828	0.665415715059358	5	0.297582954433871	0.288299059586417	1.45480280579324	NA	1.20611508964502	1.29905473838108	1.37698377457938	-0.219188590883009	NA	NA	0.69478965172667	0.864222281358346	NA	0.864222281358346	0.931176374675273	0.89957563730819	0.298253975090796	NA	NA	0.643126295436173	p.Arg142Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.671	-2.046	-0.625	10.041	10.041	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-1.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142T	142	R	T	missense	possibly_low	0.599893253972112	0.326111588350907	6	0.133134498444713	0.338954431920672	0.860832076023553	0.136787497650726	0.612041407611758	0.725765716124951	1.07084927578604	0.341422489342166	NA	NA	0.712493137317031	0.620184837009665	0.372192994630114	0.590364311939081	0.65000536208025	0.765319881045876	0.507663420138107	NA	NA	0.652017836675451	p.Arg142Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.671	-2.555	-0.116	9.946	9.946	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R142V	142	R	V	missense	wt-like	0.943767431947805	0.101864278580418	2	0.0720289221448894	0.802593338698582	1.08494152519703	NA	NA	NA	NA	0.871738509802915	NA	1.01579635409269	NA	0.770222495738488	NA	NA	NA	NA	0.70575651437338	NA	0.834688477103596	NA	p.Arg142Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.671	-3.274	0.603	19.975	19.975	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R142W	142	R	W	missense	low	0.418744252089087	0.148862214906504	4	0.0744311074532521	0.272861962151282	0.564626542026892	NA	0.270008128295152	0.357575892765288	0.427296471966061	NA	NA	NA	0.620096515329848	0.476257281844857	NA	0.432692726443372	0.469425756606894	0.48308880708282	NA	NA	NA	0.605611812812201	p.Arg142Trp	1	0	NA	NA	NA	NA	NA	NA	NA	-1.808	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.671	-5.756	3.085	0.578	NA	87.1	0.00313499	0	0.08960323	4.062e-06	1	246160	not specified	Uncertain significance(Last reviewed: Oct 27, 2014)	criteria provided, single submitter	0	0	1	0	0	15	0	2	0	0	0	2	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R142X	142	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg142Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R142Y	142	R	Y	missense	possibly_low	0.682993686823346	0.0723675112992617	4	0.0361837556496309	0.612074828924672	0.75391254472202	0.667844581558587	0.592195707254868	0.70746276293576	0.76447169554417	NA	NA	NA	NA	0.627907503183592	0.624857485327519	0.581215778068939	0.641028633620613	0.630957521039666	NA	NA	NA	NA	p.Arg142Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.5	96	46.5	0.855	115.7	-117.6	-66.5	-36	59.2452830188679	-4.2	1	0	41.62	0	0	0	0	7	23.4759851307671	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.671	-4.62	1.949	2.729	NA	87.1	0.00313499	0	0.08960323	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G143A	143	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.754	-3.212	1.458	9.895	6.325	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.725	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
G143C	143	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.754	-3.86	2.106	9.714	9.714	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.12	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G143D	143	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.754	-2.659	0.905	23.232	23.232	90.57	0.003512306	0	0.100387564	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jun 17, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.12	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G143E	143	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.754	-2.417	0.663	12.605	12.605	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.12	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
G143F	143	G	F	missense	possibly_wt-like	1.02784396645485	0.893238868244538	2	0.63161526095511	-0.210099197103033	2.26578713001273	NA	0.396228705499739	NA	NA	1.65945922740996	NA	NA	NA	0.745439144149019	NA	0.490878288298038	NA	NA	1	NA	NA	NA	p.Gly143Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.754	-4.643	2.889	3.063	NA	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G143G	143	G	G	synonymous	wt-like	1.03739050764106	0.166606733389484	8	0.0589043754855218	0.92194005315761	1.1528409621245	1.02404752379739	1.1995815504477	0.857041564939028	0.763611447791672	1.21970887041725	1.1665983277733	1.10632912194282	0.962205654019293	0.815033544073516	0.794330481193439	0.861210429744964	0.714389925376203	0.630580258061989	0.835736606953592	0.866326194142189	0.883448827707554	0.777435462989158	p.Gly143=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G143H	143	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.754	-3.335	1.581	18.185	18.185	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G143I	143	G	I	missense	low	0.356269272376352	0.128078929477341	3	0.0739464044112621	0.211336982944045	0.501201561808659	NA	0.448399490131185	0.210013198794542	NA	NA	NA	NA	0.410395128203329	0.500289698584911	NA	0.514928142001838	0.397053270000187	NA	NA	NA	NA	0.500289698584911	p.Gly143Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.754	-3.741	1.987	12.182	8.557	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.38	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G143K	143	G	K	missense	possibly_low	0.666640453301647	0.354973112399264	4	0.177486556199632	0.318773195410324	1.01450771119297	NA	0.765165683942755	0.992125518135361	NA	0.160970856113637	NA	NA	0.748299755014834	0.665476833577157	NA	0.660952026313631	0.780642182843262	NA	0.440257909071345	NA	NA	0.670001640840683	p.Gly143Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.754	-2.428	0.674	24.476	24.476	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G143L	143	G	L	missense	possibly_low	0.500862225851111	0.349623954758963	6	0.142733381835562	0.221109938061807	0.780614513640416	-0.112751615771946	0.579189077468963	0.653656724530572	0.626633640471244	NA	0.349571156649075	NA	0.908874371758761	0.572864185092	0.253468143926569	0.57521994063348	0.614639329596309	0.57050842955052	NA	0.463635814520571	NA	0.75064993009832	p.Gly143Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.754	-3.159	1.405	15.654	15.654	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.685	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
G143M	143	G	M	missense	possibly_wt-like	0.786373290451199	0.153912272903562	7	0.0581733711176472	0.672355578201328	0.90039100270107	0.933882558090987	0.706173305936233	0.900739209770878	NA	0.920540313657652	0.557032942590499	0.62796101094905	0.858283692163096	0.723985834169241	0.751432107686551	0.633757532868329	0.735821542882215	NA	0.723985834169241	0.565888063026305	0.625802923757908	0.725240859570827	p.Gly143Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.754	-4.071	2.317	3.979	3.979	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G143N	143	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.754	-2.465	0.711	13.911	13.911	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
G143P	143	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.754	-4.312	2.558	2.637	NA	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G143Q	143	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.754	-2.866	1.112	19.217	19.217	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G143R	143	G	R	missense	wt-like	0.976882363063214	0.172871951437404	8	0.0611194645691699	0.857090413753269	1.09667431237316	0.703941895339948	0.904132244390693	1.09547793583015	0.892093313205185	1.1316754529704	0.849554858035646	1.23641525707175	1.00176794766194	0.761159410017243	0.642031739618597	0.725013271934205	0.831331630589925	0.686926178156179	0.802852795442481	0.710064126370885	0.953512360594357	0.797305548100281	p.Gly143Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.754	-2.508	0.754	30.648	30.648	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
G143S	143	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.754	-2.952	1.198	19.919	19.919	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.375	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
G143T	143	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.754	-3.93	2.176	7.439	NA	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.275	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G143V	143	G	V	missense	low	0.426310039357407	0.304110722683073	8	0.107519377120371	0.2155759325613	0.637044146153515	0.899158665701696	0.276913738460908	0.624718688998529	0.668234121871719	0.170611166377847	0.0149071403735058	0.198696394192934	0.557240398882119	0.508950690041475	0.73491129504432	0.435876096511412	0.600446598814487	0.588752384783633	0.443858929625026	0.298689060578144	0.394603837372386	0.574042450457924	p.Gly143Val	1	0	NA	NA	NA	NA	NA	NA	NA	8.945	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.754	-3.542	1.788	19.975	19.975	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.275	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G143W	143	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.754	-5.732	3.978	0.641	NA	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.275	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G143X	143	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G143Y	143	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly143Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	95.2	48.8	0.586	75.8	128	107.7	16.2	44.3298969072165	-1.9	0	0	44.95	0	0	0	0	6	25.014417799741	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.754	-3.848	2.094	7.403	7.403	90.57	0.003512306	0	0.100387564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K144A	144	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.476	-3.017	0.541	11.285	11.285	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.615	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K144C	144	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.476	-5.437	2.961	0.835	NA	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K144D	144	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.476	-3.098	0.622	16.44	16.44	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K144E	144	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.476	-3.022	0.546	22.04	22.04	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	0.9	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
K144F	144	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.476	-2.641	0.165	16.929	16.929	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.245	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K144G	144	K	G	missense	wt-like	0.788315039938988	0.0515517470109163	3	0.029763415013948	0.729979818454731	0.846650261423244	NA	0.731515136666819	0.801290632234025	0.832139350916118	NA	NA	NA	NA	0.660633275592869	NA	0.645439690343294	0.687046743153574	0.660633275592869	NA	NA	NA	NA	p.Lys144Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.476	-3.407	0.931	16.067	16.067	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.075	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K144H	144	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.476	-3.52	1.044	14.759	14.759	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.335	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K144I	144	K	I	missense	wt-like	1.16549077965915	0.247062430526655	7	0.0933808213543858	0.982467732957785	1.34851382636052	NA	1.29670557326538	1.09892981655741	1.50009408499743	1.17210642302695	1.25423356764319	1.14444687170377	0.691919120419931	0.903978795880566	NA	0.905982969709444	0.833024613992296	0.953565853680445	0.817955292165996	0.909519210554213	0.903978795880566	0.641684576664904	p.Lys144Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.476	-2.588	0.112	12.397	12.397	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.375	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
K144L	144	K	L	missense	wt-like	0.982176513103317	0.232552020392721	7	0.0878964018349657	0.809902731136124	1.15445029507051	0.99513975353033	1.37401917623479	1.1371113303339	1.03861770460445	0.697173772503451	NA	0.877894125699896	0.755279728816391	0.760415248026678	0.780576842887784	0.941623239524503	0.851750831439646	0.751184675828681	0.640549981623389	NA	0.760415248026678	0.673507319120186	p.Lys144Leu	0	0	NA	NA	NA	NA	NA	NA	NA	-1.118	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.476	-2.455	-0.021	19.102	19.102	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.185	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K144M	144	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.476	-3.102	0.626	6.471	6.471	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K144N	144	K	N	missense	possibly_low	0.592452613366926	0.121772765426173	3	0.0703055388987661	0.454656289211665	0.730248937522188	NA	0.693448727363117	0.626680261546122	NA	NA	NA	NA	0.457228851191541	0.601408656900502	NA	0.627891716295168	0.601408656900502	NA	NA	NA	NA	0.523811844956206	p.Lys144Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.476	-3.751	1.275	8.724	8.724	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.795	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
K144P	144	K	P	missense	possibly_low	0.61518439756061	0.126024777809662	4	0.0630123889048308	0.49168238472731	0.738686410393909	NA	0.496393125822363	0.735363742243268	0.712192278580158	NA	NA	NA	0.51678844359665	0.580877918336028	NA	0.537052400343749	0.654712737623532	0.608030302156718	NA	NA	NA	0.553725534515337	p.Lys144Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.476	-3.639	1.163	15.223	15.223	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.795	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K144Q	144	K	Q	missense	wt-like	1.08469479186174	0.179929681368194	7	0.0680070271970475	0.951403467859894	1.21798611586359	NA	1.10847790726624	1.19917855627151	1.15359683656124	1.08606016766193	0.687324780001494	1.18597658285905	1.17224871241074	0.819213183472446	NA	0.819213183472446	0.882191855231034	0.801608951354922	0.785813760862066	0.630105351413957	0.926346423917354	0.88292918094538	p.Lys144Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.476	-2.484	0.008	9.661	9.661	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	-0.535	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
K144R	144	K	R	missense	possibly_wt-like	0.841456193947278	0.259651669675433	7	0.0981391064948409	0.649107079742449	1.03380530815211	1.08469907986241	0.859158388938357	0.888109300646551	0.931048219743345	0.281479754826273	0.986122265770724	NA	0.859576347843289	0.725890093374529	0.823187067401468	0.704281081460831	0.729627172853124	0.704009912456046	0.485272541305406	0.777374471985349	NA	0.725890093374529	p.Lys144Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.476	-2.807	0.331	31.245	31.245	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.47	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
K144S	144	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.476	-3.392	0.916	7.967	7.967	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.335	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K144T	144	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.476	-3.051	0.575	8.421	8.421	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K144V	144	K	V	missense	wt-like	1.13381508196908	0.142679284168927	2	0.100889489370691	0.936075316383888	1.33155484755427	NA	1.23470457133977	1.03292559259839	NA	NA	NA	NA	NA	0.839027115549177	NA	0.877401551271258	0.800652679827096	NA	NA	NA	NA	NA	p.Lys144Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.476	-2.788	0.312	8.885	8.885	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K144W	144	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.476	-4.331	1.855	18.359	18.359	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K144X	144	K	X	nonsense	low	-0.0188865964429966	0.0278515986753895	3	0.0160801279925976	-0.0504030681752822	0.0126298752892889	-0.0225720589262167	0.0106242495426386	NA	NA	NA	NA	NA	-0.0447119799454117	0.296373459554929	0.296373459554929	0.313121123654748	NA	NA	NA	NA	NA	0.271713037805962	p.Lys144Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K144Y	144	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys144Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.8	96.9	46.9	0.929	84	16.9	-67.8	-44.1	53.0434782608696	-2.8	0	0	37.59	0	0	0	0	5	23.8038055331495	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.476	-3.044	0.568	10.081	10.081	90.82	0.003163333	0	0.090413329	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
F145A	145	F	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.753	-2.426	0.673	10.71	10.71	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.82	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
F145C	145	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.753	-2.5	0.747	23.265	23.265	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	0.925	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F145D	145	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.753	-4.228	2.475	3.369	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.975	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145E	145	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.753	-3.535	1.782	11.057	11.057	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.63	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145G	145	F	G	missense	low	0.4416140655557	0.0984462781524808	7	0.0372091956416222	0.368685382204415	0.514542748906984	0.567448423028542	0.386400471496593	0.509725190230725	0.499689821613052	0.267506505354389	NA	0.448759745142533	0.411768302024064	0.514837022143614	0.577091350515219	0.486347637827432	0.544047754191325	0.514837022143614	0.480053004052879	NA	0.529286305997319	0.500979372468251	p.Phe145Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.753	-3.905	2.152	2.897	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.63	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F145H	145	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.753	-3.688	1.935	15.022	15.022	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.515	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145I	145	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.753	-3.029	1.276	8.557	8.557	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.165	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F145K	145	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.753	-3.065	1.312	11.275	11.275	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145L	145	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.753	-3.042	1.289	27.861	27.861	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.28	Deleterious	TOLERATED	effect	DAMAGING	null	N	D	D	D	D	D	0.785714285714286
F145M	145	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.753	-3.479	1.726	5.587	5.587	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.77	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F145N	145	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.753	-4.356	2.603	2.315	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.77	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145P	145	F	P	missense	low	0.151735395520214	0.0705953853636647	3	0.0407582647432572	0.0718506645510812	0.231620126489347	NA	0.228276748331969	0.0891794475088102	0.137749990719863	NA	NA	NA	NA	0.356107751481364	NA	0.413455262601064	0.33779005914895	0.356107751481364	NA	NA	NA	NA	p.Phe145Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.753	-4.48	2.727	1.104	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.32	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145Q	145	F	Q	missense	low	0.138228954284467	0.184054563338611	3	0.106263951689126	-0.0700445638811236	0.346502472450059	0.345277263163108	NA	0.0762298600936031	-0.00682026040330896	NA	NA	NA	NA	0.331438902114943	0.471387529483447	NA	0.331438902114943	0.292706245038678	NA	NA	NA	NA	p.Phe145Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.753	-3.047	1.294	8.865	8.865	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.93	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F145R	145	F	R	missense	low	0.284991664705442	0.238039444200828	6	0.0971791961579563	0.0945239401892943	0.475459389221589	NA	0.146099814327298	0.478165029664608	0.56755218519498	-0.063587705032024	NA	0.17841015932303	0.403310504754759	0.440204632764206	NA	0.375573079026469	0.528568995729992	0.544598166282388	0.356376791967403	NA	0.383677805304878	0.496731460223533	p.Phe145Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.753	-4.334	2.581	4.362	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.975	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F145S	145	F	S	missense	possibly_wt-like	0.747509115786865	0.147775640562574	2	0.104493157535982	0.54270629038547	0.95231194118826	NA	NA	NA	NA	0.852002273322847	NA	NA	0.643015958250883	0.657753670979618	NA	NA	NA	NA	0.69838428347321	NA	NA	0.617123058486025	p.Phe145Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.753	-2.868	1.115	6.821	6.821	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.62	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F145T	145	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.753	-3.934	2.181	2.548	NA	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.77	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F145V	145	F	V	missense	possibly_low	0.584132718082223	0.169080325572279	3	0.0976185714838251	0.392803833751677	0.775461602412769	NA	0.41178886477926	0.749748673251543	0.590860616215864	NA	NA	NA	NA	0.554820114629704	NA	0.498051259855279	0.661767862457057	0.554820114629704	NA	NA	NA	NA	p.Phe145Val	1	0	NA	NA	NA	NA	NA	NA	NA	5.553	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.753	-2.924	1.171	9.42	9.42	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.28	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F145W	145	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.753	-3.143	1.39	20.576	20.576	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.62	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F145X	145	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F145Y	145	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe145Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	93.6	47.2	0.784	60.5	-157.4	-121.7	166.5	16.2280701754386	-1.7	0	0	42.07	0	0	0	0	6	23.2241145764483	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.753	-2.44	0.687	15.831	15.831	74.19	0.003244768	0	0.09274088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.555	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L146A	146	L	A	missense	wt-like	1.11439619086945	0.0469138910788455	2	0.0331731305136987	1.04937804980815	1.17941433193075	NA	1.08122306035575	NA	NA	NA	NA	NA	1.14756932138315	0.838591581244221	NA	0.806649157733766	NA	NA	NA	NA	NA	0.870534004754676	p.Leu146Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.564	-2.669	0.105	25.588	25.588	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.23	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146C	146	L	C	missense	possibly_wt-like	0.862080942002173	0.417169618753021	6	0.170308783689382	0.528281859720161	1.19588002428418	0.657789100830628	1.12623929360529	1.12923184510355	1.14353829164332	0.0979908396680459	NA	NA	1.01769628116221	0.801251641815181	0.620073323711311	0.827400883658451	0.847886318506487	0.797197760978872	0.416732490544754	NA	NA	0.80530552265149	p.Leu146Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.564	-4.066	1.502	14.751	14.751	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.02	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L146D	146	L	D	missense	wt-like	1.03085677087486	0.243907267431254	7	0.0921882817977746	0.850171058754592	1.21154248299513	NA	0.752785761993413	1.20951255784658	1.2187446107704	1.05981048624955	1.21753922604244	1.13421535565049	0.623389397571146	0.830179608140527	NA	0.655245090643611	0.887260191749301	0.830179608140527	0.776008511891554	0.891433571702279	0.898468168935038	0.607265656519709	p.Leu146Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.564	-2.78	0.216	17.424	17.424	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.98	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146E	146	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu146Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.564	-2.433	-0.131	12.31	12.31	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.455	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146F	146	L	F	missense	possibly_low	0.680974507752302	0.32328429653569	7	0.122189978772271	0.441486550086937	0.920462465417667	NA	0.465186475760809	0.635975217135264	0.14812319345631	0.70003183572889	0.734640751866721	0.916024760822495	1.16683931949563	0.641617576351822	NA	0.52266665985953	0.605967390756489	0.360656935528681	0.641617576351822	0.653426101746356	0.78095215617034	0.880212323864399	p.Leu146Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.564	-3.609	1.045	24.772	24.772	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	low	1.47	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.642857142857143
L146G	146	L	G	missense	wt-like	1.02758783344365	0.101280057416642	8	0.0358079076991352	0.957405623991608	1.09777004289569	1.07222276279316	1.03210673042759	1.07140422385622	1.19702928070932	1.00610118742978	0.835050989910842	1.01852241032003	0.988265082102244	0.803887444403764	0.817251128698072	0.784007356243057	0.819524619274771	0.820656316674429	0.755946057087395	0.702915565873047	0.836156712976281	0.790523760109455	p.Leu146Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.564	-3.148	0.584	44.913	44.913	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146H	146	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu146His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.564	-3.749	1.185	32.153	32.153	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L146I	146	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu146Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.564	-3.454	0.89	10.713	10.713	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.675	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
L146K	146	L	K	missense	wt-like	1.11188375749874	0.28347546281541	3	0.163664634765131	0.791106967816181	1.4326605471813	NA	1.3501441391065	1.18713034240509	0.798376790984631	NA	NA	NA	NA	0.876282779073511	NA	0.930617249214705	0.876282779073511	0.645826652899836	NA	NA	NA	NA	p.Leu146Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.564	-2.596	0.032	24.132	24.132	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146L	146	L	L	synonymous	wt-like	0.837798745717814	0.145509684887764	8	0.0514454424562277	0.73696753133488	0.938629960100748	1.08275760655412	0.85988132528735	0.939339900760499	0.617579073024317	0.679948255215293	0.800643300373821	0.833492415432464	0.888748089094645	0.72055756159736	0.822263359989394	0.704614342951017	0.754753346825899	0.566537535041711	0.634115599315931	0.685956955374818	0.736500780243704	0.740541543736327	p.Leu146=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L146M	146	L	M	missense	wt-like	1.01639200336564	0.150355681815046	7	0.0568291060411668	0.905009002251342	1.12777500447993	1.10793412599019	0.981567551804616	1.07555736193394	1.13608606950287	0.949939019604243	1.14337615139098	NA	0.720283743332627	0.793929577473763	0.834241756763685	0.760709645449951	0.821561536071408	0.793929577473763	0.734967362923385	0.854880617601363	NA	0.655930653409369	p.Leu146Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.564	-3.434	0.87	14.549	14.549	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.675	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L146N	146	L	N	missense	wt-like	0.976617260238344	0.0461177416184398	2	0.0326101678314079	0.912702505758978	1.04053201471771	NA	NA	NA	NA	NA	NA	1.00922742806975	0.944007092406936	0.799722883864525	NA	NA	NA	NA	NA	NA	0.831150496949268	0.768295270779782	p.Leu146Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.564	-2.839	0.275	10.61	10.61	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.125	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146P	146	L	P	missense	wt-like	0.981411628544269	0.157999252175817	6	0.0645029245953461	0.854988219439888	1.10783503764865	NA	1.15103130416307	0.906970513030575	1.19043489377952	0.777603460672603	NA	0.920293113267666	0.94213648635218	0.77530341255963	NA	0.838829583286982	0.738877700909488	0.817764338123055	0.670593512618291	NA	0.783251062595827	0.767355762523433	p.Leu146Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.564	-2.741	0.177	44.195	44.195	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.12	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146Q	146	L	Q	missense	wt-like	0.933055018880147	0.156568243483309	6	0.0639187177429909	0.807776634165904	1.05833340359439	1.14364860463948	0.798933786779244	1.07907068425898	NA	0.751063700310092	0.962648945524459	NA	0.862964391768625	0.746698422672836	0.851233867088331	0.676518553418974	0.823284653656699	NA	0.660679908186909	0.765805113492728	NA	0.727591731852944	p.Leu146Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.564	-2.779	0.215	19.111	19.111	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.74	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146R	146	L	R	missense	wt-like	1.0538557096946	0.185374661794843	7	0.0700650363545517	0.916530761864192	1.19118065752501	1.26688036548089	0.972986223694973	0.736250069124926	NA	1.14094264150604	1.2496472076274	0.968227486322511	1.04205597410549	0.809068199215404	0.909864645274393	0.756753797611373	0.655147438825075	NA	0.806314440916235	0.907258718955997	0.809068199215404	0.817540131100532	p.Leu146Arg	0	0	NA	NA	NA	NA	NA	NA	NA	1.47	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.564	-3.199	0.635	28.087	28.087	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.47	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146S	146	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu146Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.564	-2.921	0.357	10.041	10.041	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.5	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
L146T	146	L	T	missense	possibly_low	0.203377590237951	0.726151936689718	3	0.419244016120377	-0.618325582091917	1.02508076256782	NA	NA	NA	NA	-0.348369550675429	-0.0675376052183572	NA	1.02603992660764	0.258054297043276	NA	NA	NA	NA	0.25	0.258054297043276	NA	0.809496102364469	p.Leu146Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.564	-2.671	0.107	21.662	21.662	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.43	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L146V	146	L	V	missense	wt-like	0.8741087058309	0.177817719954487	8	0.0628680577974742	0.750889576769868	0.997327834891932	1.06665385419989	0.581077393601366	0.788559241742444	0.735876414391785	1.02809125992945	0.847755215753929	1.09122959872625	0.853626668302078	0.716039505111938	0.814601572753722	0.57609042259099	0.680802601338032	0.618417016419053	0.764160180998141	0.709177131838488	0.87531632426735	0.722901878385388	p.Leu146Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.162	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.564	-3.073	0.509	10.756	10.756	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.565	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
L146W	146	L	W	missense	wt-like	0.969005176843106	0.0386309344551419	2	0.0273161957168039	0.915466417043523	1.02254393664269	NA	NA	NA	NA	NA	0.99632137255991	NA	0.941688981126302	0.774766168538609	NA	NA	NA	NA	NA	0.782401333183964	NA	0.767131003893254	p.Leu146Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.564	-5.787	3.223	1.151	NA	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.47	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L146X	146	L	X	nonsense	low	-0.071126799147516	0.105250685646862	5	0.0470695375569692	-0.163381397528131	0.021127799233099	NA	-0.029866244971871	-0.0081032798606672	-0.00737245432047055	-0.256273053407345	NA	-0.0540189631772259	NA	0.290077505967947	NA	0.294455687120725	0.290077505967947	0.292464079545261	0.28440152552098	NA	0.258493015611442	NA	p.Leu146Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	4	1	0	1	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L146Y	146	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu146Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.2	90.6	49.4	0.589	75.9	59.4	-115.9	-21.4	67.0157068062827	-1	0	0	42.33	0	0	0	0	4	24.7625010420999	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.564	-3.46	0.896	9.845	9.845	58.31	0.003476824	0	0.099373419	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K147A	147	K	A	missense	wt-like	0.9852779507092	0.152378914293261	7	0.0575938160385705	0.872396145541377	1.09815975587702	NA	1.09500171431696	0.974015211151833	0.992556338823661	1.17292078577087	0.703132810341032	0.901499233122068	1.05781956143798	0.773128802922676	NA	0.813000885321215	0.771759938189552	0.730984392875436	0.818259487456256	0.637896697850746	0.773128802922676	0.825457362209083	p.Lys147Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.558	-2.932	0.374	9.488	9.488	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K147C	147	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.558	-3.839	1.281	18.828	18.828	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K147D	147	K	D	missense	wt-like	1.04295372479469	0.0997829883358256	3	0.0576097351762342	0.930040718690385	1.155866730899	NA	0.962055698352494	1.01235151178045	1.15445396425113	NA	NA	NA	NA	0.790562071229666	NA	0.751715009384411	0.790562071229666	0.801984846024336	NA	NA	NA	NA	p.Lys147Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.558	-2.546	-0.012	35.045	35.045	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.3	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K147E	147	K	E	missense	wt-like	0.982746265165859	0.0769057795216869	3	0.044401572509084	0.89572078219111	1.06977174814061	NA	NA	NA	NA	0.946042157033843	1.07112763636772	0.931069002096017	NA	0.789054885121275	NA	NA	NA	NA	0.733511737344303	0.819271297654534	0.789054885121275	NA	p.Lys147Glu	1	0	NA	NA	NA	NA	NA	NA	NA	-0.021	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.558	-2.846	0.288	26.684	26.684	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
K147F	147	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.558	-4.632	2.074	1.685	NA	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K147G	147	K	G	missense	wt-like	0.98597597962623	0.0910371504891234	8	0.0321864932253797	0.922891612115844	1.04906034713662	1.10754579575031	1.00929285281933	0.989721784858516	1.05458990136794	1.05197668016441	0.862678899613981	0.959006959711805	0.852994962723548	0.773286415798828	0.83405699835399	0.773490542613147	0.779463265938837	0.758189307335763	0.77308228898451	0.716532608047055	0.804102084503928	0.722584605485997	p.Lys147Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.558	-3.156	0.598	11.133	11.133	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.35	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K147H	147	K	H	missense	wt-like	0.985635147346719	0.15173490399909	2	0.107292779560446	0.775345163607049	1.19592513108639	NA	NA	0.878342367786273	1.09292792690717	NA	NA	NA	NA	0.749919732052574	NA	NA	0.724836956582342	0.775002507522806	NA	NA	NA	NA	p.Lys147His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.558	-3.745	1.187	10.805	10.805	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K147I	147	K	I	missense	wt-like	1.04226704645495	0.13921596386075	3	0.0803763742104971	0.884732247794462	1.19980184511544	NA	NA	1.13508252680771	1.10952570214314	NA	NA	NA	0.882192910413995	0.782281487433144	NA	NA	0.850755799754632	0.782281487433144	NA	NA	NA	0.737249217980908	p.Lys147Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.558	-3.667	1.109	5.948	5.458	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K147L	147	K	L	missense	wt-like	1.01663774254342	0.184595284513812	6	0.075360709330454	0.868933466406343	1.16434201868051	NA	1.2809356924423	1.15620216217607	1.04509227251978	0.952826884972735	0.896671673918732	NA	0.76809776923092	0.745035098723094	NA	0.898713320050146	0.861113976924657	0.754024107566595	0.736046089879593	0.73328671815864	NA	0.67994515501249	p.Lys147Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.558	-3.113	0.555	11.554	11.554	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K147M	147	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.558	-4.058	1.5	4.421	4.421	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K147N	147	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.558	-2.326	-0.232	13.125	13.125	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.04	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
K147P	147	K	P	missense	low	0.37588818415276	0.101387866216509	5	0.0453420321907538	0.287019434073027	0.464756934232493	NA	0.361242506688854	0.33476868476223	0.469406623579918	0.478983548904238	NA	NA	0.23503955682856	0.474750239448516	NA	0.474750239448516	0.458239905282812	0.501556278973519	0.559047679492101	NA	NA	0.412217703583837	p.Lys147Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.558	-3.451	0.893	11.54	11.54	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
K147Q	147	K	Q	missense	wt-like	1.04137152538512	0.182353260518103	7	0.0689230540132391	0.906284821814666	1.17645822895558	1.27115759423294	1.32188755001134	0.962638127035437	0.990739032553764	0.897362008496346	NA	0.850600068366557	0.995216296999473	0.766180019270475	0.911899650280412	0.917591437187772	0.766180019270475	0.730187410409928	0.715327860411361	NA	0.74571484908183	0.794014994285139	p.Lys147Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.558	-3.317	0.759	5.999	5.999	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.775	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
K147R	147	K	R	missense	wt-like	1.18557073287859	0.157706921927315	8	0.055757816967431	1.07628741976585	1.29485404599133	1.20602091219833	1.07425781172937	1.15725625252333	1.05693552980488	1.54894104579443	1.08025761212636	1.19996111081867	1.16093558803331	0.869439072169799	0.880909146451919	0.803438295339068	0.861630958130993	0.759217986301883	0.958717278526764	0.823771213366181	0.933878398279069	0.877247186208605	p.Lys147Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.558	-3.268	0.71	30.733	30.733	86.35	0.003655099	0	0.104468829	1.219e-05	3	246098	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K147S	147	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.558	-1.981	-0.577	12.006	12.006	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.515	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K147T	147	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.558	-1.986	-0.572	13.486	13.486	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.76	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K147V	147	K	V	missense	possibly_low	0.625651743480413	0.187990245867579	8	0.0664645888249457	0.495383543136256	0.75591994382457	0.839503453055005	0.830314134081755	0.378076298859674	0.418427846524864	0.652192902736402	0.451227858014772	0.656741093817159	0.778730360753675	0.632525805741785	0.706528745639449	0.690984365408026	0.479480231254748	0.4791994577272	0.623747925246124	0.513739626377533	0.641303686237446	0.685285353445303	p.Lys147Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.558	-3.298	0.74	9.754	9.754	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K147W	147	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.558	-5.797	3.239	0.46	NA	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K147X	147	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K147Y	147	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys147Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	88	47.3	0.938	73.8	-134.5	-119.2	134.6	53.9130434782609	-2.9	0	0	40.21	0	0	0	0	6	22.814080254527	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.558	-4.639	2.081	1.771	NA	86.35	0.003655099	0	0.104468829	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148A	148	A	A	synonymous	possibly_wt-like	0.876207333201726	0.421296626651589	8	0.148950850798178	0.584269030170699	1.16814563623275	1.24628263945021	1.06968604375993	1.01897550912537	0.914545891558764	1.17388433654348	-0.018464091058676	1.07278345448621	0.531964881748528	0.797570807141986	0.900064730887095	0.801330787245992	0.793810827037979	0.696772790997202	0.818619410118659	0.282241291974102	0.865381352855397	0.561347871088777	p.Ala148=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A148C	148	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.375	-5.066	3.691	0.936	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A148D	148	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.375	-3.352	1.977	10.041	10.041	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148E	148	A	E	missense	low	0.244952040605555	0.251329081201658	7	0.0949934637282779	0.0587682729314181	0.431135808279691	NA	0.229436462952785	0.491701240524023	0.371545093749685	-0.199878429192922	0.520592679585892	0.0792112753630319	0.222055961256389	0.413989871523775	NA	0.413989871523775	0.535207863676674	0.458638954241639	0.305467050939512	0.547927652575518	0.330249941822141	0.405696717935286	p.Ala148Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.375	-3.286	1.911	7.887	7.887	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A148F	148	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.375	-3.641	2.266	13.39	13.39	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148G	148	A	G	missense	low	0.489498330140286	0.121065454933667	8	0.0428031020755151	0.405605791645684	0.573390868634887	0.400285429584727	0.322278153515701	0.597620397782646	0.711629169434256	0.468672095028597	0.421149699415809	0.482671808775214	0.511679887585336	0.54935544579692	0.497559123412373	0.456788328388573	0.587156175162592	0.607783349772915	0.555195961411785	0.498914923439111	0.547551119409085	0.551159772184755	p.Ala148Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.375	-2.919	1.544	16.32	16.32	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.525	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A148H	148	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.375	-5.039	3.664	1.089	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148I	148	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.375	-3.935	2.56	6.519	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148K	148	A	K	missense	low	0.241631344172194	0.259812119797764	4	0.129906059898882	-0.0129798546031172	0.496242542947505	NA	-0.0154478000976417	0.196447498624875	0.603350456188075	NA	NA	NA	0.182175221973468	0.388033316534382	NA	0.301102347551676	0.390399938948678	0.56029755319894	NA	NA	NA	0.385666694120087	p.Ala148Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.375	-3.12	1.745	7.769	7.769	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148L	148	A	L	missense	low	0.377003400767219	0.22249385564289	5	0.0995022771587056	0.181982521156434	0.572024280378005	NA	0.374820687503323	0.2909958059111	0.355991415517957	0.735090888678741	NA	NA	0.128118206224974	0.451817864681684	NA	0.481009552289192	0.436771389066793	0.451817864681684	0.654713458829142	NA	NA	0.358516662995046	p.Ala148Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.375	-3.574	2.199	5.161	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148M	148	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.375	-3.538	2.163	3.256	3.256	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148N	148	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.375	-4.105	2.73	2.824	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148P	148	A	P	missense	wt-like	0.886220123863932	0.210203555951768	8	0.0743181799215104	0.740559167821204	1.03188107990666	1.10065026150984	0.847262740945675	0.652570387989002	0.67331901910261	1.00270204863461	0.633733079100452	1.11896436890843	1.06055908472085	0.72673686905039	0.830776265077381	0.698797387934714	0.614106533164571	0.590982374301117	0.754676350166066	0.603691465630069	0.89025408824074	0.826833282454915	p.Ala148Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.375	-2.131	0.756	43.458	43.458	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.385	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
A148Q	148	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.375	-4.251	2.876	1.93	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148R	148	A	R	missense	low	0.286072849753841	0.17716902832477	8	0.0626387106723383	0.163303232798033	0.408842466709648	0.201598739673821	0.170260948074122	0.274227155153591	0.450046968272319	0.100272140455997	0.15681907159547	0.633443780774323	0.301913994031082	0.423065902848987	0.403028661742829	0.386710955062529	0.428547163012741	0.493066072301144	0.417584642685234	0.368633575860269	0.628755907360527	0.445805259729473	p.Ala148Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.375	-4.162	2.787	3.006	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148S	148	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.375	-2.272	0.897	11.296	11.296	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.485	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
A148T	148	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.375	-2.616	1.241	10.801	10.801	87.84	0.002895863	0	0.082768596	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Aug 7, 2015)	criteria provided, single submitter	0	0	1	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.525	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
A148V	148	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.375	-2.493	1.118	10.689	10.689	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A148W	148	A	W	missense	possibly_low	0.548444316655894	0.607568732845609	2	0.429615971032048	-0.293587513750122	1.39047614706191	0.978060287687942	NA	NA	NA	NA	NA	NA	0.118828345623846	0.563150841321979	0.772450834085311	NA	NA	NA	NA	NA	NA	0.353850848558647	p.Ala148Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.375	-5.681	4.306	0.622	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A148X	148	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A148Y	148	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala148Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	86.8	43.8	0.885	106.1	53.8	-46.4	-52.5	2.47933884297521	-3.5	1	0	36.22	0	0	0	0	6	19.2444282289706	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.375	-4.529	3.154	3.106	NA	87.84	0.002895863	0	0.082768596	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q149A	149	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln149Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.532	-2.775	0.243	13.944	13.944	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.99	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q149C	149	Q	C	missense	wt-like	0.931668056838843	0.137439007367499	7	0.051947061990568	0.82985368623466	1.03348242744303	NA	0.760441742423621	1.19090277227294	0.970668096278973	0.8096746032624	0.930581610868006	0.943907538862979	0.915500033902977	0.75	NA	0.658774368775162	0.878132976591187	0.72138527037316	0.682573297550592	0.75	0.795969636198312	0.753977656036363	p.Gln149Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.532	-5.52	2.988	1.032	NA	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q149D	149	Q	D	missense	possibly_wt-like	0.885675301064363	0.322016670237007	8	0.11385008558985	0.662533233671454	1.10881736845727	0.411924311049422	1.31042077878996	1.07447102124999	1.1036521283551	0.439851747899568	0.916657982941436	0.779102207878177	1.04932223035125	0.761421523322755	0.503096629919065	0.912305448635416	0.82102873760803	0.779705622596007	0.544430471553938	0.743137424049502	0.707206573817148	0.821189594181379	p.Gln149Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.532	-2.237	-0.295	21.756	21.756	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q149E	149	Q	E	missense	wt-like	1.17756225561879	0.260111329542307	6	0.106190005615929	0.969433669093464	1.38569084214412	NA	0.950605357032744	0.994491345205913	1.06866765710122	1.65945922740996	1.13089460729266	1.26125533967025	NA	0.815265656970976	NA	0.746436594740201	0.781802508555473	0.764363128809321	1	0.84872880538648	0.966891064960702	NA	p.Gln149Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.532	-2.116	-0.416	15.258	15.258	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	-0.54	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
Q149F	149	Q	F	missense	possibly_low	0.520800876558316	0.233192462758986	4	0.116596231379493	0.292276462321411	0.749325290795221	NA	0.503879932459716	0.688588065879316	0.693679053367442	NA	NA	NA	0.197056454526791	0.570207495455446	NA	0.540503692203914	0.631771491973457	0.599911298706978	NA	NA	NA	0.393140764255247	p.Gln149Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.532	-3.942	1.41	12.912	12.912	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q149G	149	Q	G	missense	wt-like	1.03873074878755	0.0914799724947123	8	0.032343054446885	0.975339526921634	1.10212197065346	0.895623251965578	0.969968268759934	0.972597025959069	1.02773196364628	1.17946218082478	1.12005665964184	1.08262816852971	1.06177847097317	0.795883665862009	0.733229228204221	0.75536257117717	0.771064385769714	0.7464107173543	0.820702945954303	0.84338707697392	0.8706836507941	0.827445716830835	p.Gln149Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.532	-3.063	0.531	26.062	26.062	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q149H	149	Q	H	missense	possibly_wt-like	0.749467223252827	0.653275597061859	3	0.377168841818678	0.0102298771975333	1.48870456930812	0.0625976684631472	NA	NA	NA	1.36295137899133	NA	0.822852622304002	NA	0.730770257963017	0.336895215964461	NA	NA	NA	0.889243102429268	NA	0.730770257963017	NA	p.Gln149His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.532	-3.484	0.952	12.826	12.826	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.165	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
Q149I	149	Q	I	missense	possibly_low	0.608663432560568	0.273039169861557	6	0.111467774325653	0.39019060944545	0.827136255675687	NA	0.768636045933159	0.685590462550551	0.557855172571636	0.0962137916174162	NA	0.665067174449902	0.878617948240745	0.638044684147329	NA	0.662551804786545	0.630301310039762	0.540345526451321	0.416068695876344	NA	0.645788058254896	0.735453700175668	p.Gln149Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.532	-3.457	0.925	9.702	9.702	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.245	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q149K	149	Q	K	missense	possibly_wt-like	0.999516430142603	0.34271404529044	2	0.242335425432744	0.524547724116234	1.47448513616897	NA	NA	NA	NA	NA	1.24185185557535	NA	0.757181004709859	0.788939417032085	NA	NA	NA	NA	NA	0.903416602820734	NA	0.674462231243436	p.Gln149Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.532	-2.501	-0.031	24.407	24.407	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	-0.02	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
Q149L	149	Q	L	missense	possibly_low	0.540685420607057	0.239910889186345	7	0.090677792800492	0.362960212520508	0.718410628693607	0.356051300248425	0.572176122281318	0.666759543922579	0.449318420139162	0.905672528263031	0.17001343801858	NA	0.664806591376306	0.571987086316918	0.476513563341963	0.571987086316918	0.621065639630647	0.492746566394505	0.718432153911406	0.375136718731856	NA	0.62806736163332	p.Gln149Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.532	-3.24	0.708	13.791	13.791	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
Q149M	149	Q	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln149Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.532	-4.18	1.648	6.471	6.471	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q149N	149	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln149Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.532	-2.931	0.399	14.304	14.304	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q149P	149	Q	P	missense	possibly_low	0.640742526663987	0.194028525015918	4	0.0970142625079588	0.450598066161674	0.830886987166301	NA	0.458915135348569	0.868523425074621	0.733826113541213	NA	NA	NA	0.501705432691545	0.581833987708077	NA	0.51977567747338	0.720021231951889	0.617517853821097	NA	NA	NA	0.546150121595057	p.Gln149Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.532	-3.577	1.045	12.522	12.522	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.79	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.785714285714286
Q149Q	149	Q	Q	synonymous	wt-like	1.13287387122972	0.12739777593408	7	0.0481518332434722	1.03849801228294	1.2272497301765	0.990000925444672	1.08221028958526	1.20132293409769	1.32677250859529	1.24311857179697	NA	0.998987564093332	1.08770430499483	0.840466916593426	0.778131909150171	0.807104253793937	0.883243570616062	0.877555409224936	0.844481015952217	NA	0.825635373867495	0.840466916593426	p.Gln149=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	NA	NA	NA	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q149R	149	Q	R	missense	wt-like	1.09484588352595	0.103813376906692	7	0.0392377682938463	1.01794127083628	1.17175049621562	1.11218303179132	1.06288193735419	1.02845884684352	1.21021935441496	1.2328363703454	0.932090473844103	1.08525117008816	NA	0.826440843826666	0.83626328637471	0.798194208703055	0.798461953372996	0.826440843826666	0.84064022475884	0.750743677353845	0.872096382103021	NA	p.Gln149Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.532	-2.901	0.369	10.671	10.671	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.571428571428571
Q149S	149	Q	S	missense	possibly_low	0.654723147381437	0.824750978503522	2	0.583187009690081	-0.488302387862732	1.79774868262561	NA	NA	NA	NA	1.23791015707152	0.0715361376913566	NA	NA	0.584567711423794	NA	NA	NA	NA	0.842535476030325	0.326599946817263	NA	NA	p.Gln149Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.532	-2.842	0.31	10.969	10.969	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.03	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q149T	149	Q	T	missense	wt-like	0.969053081002316	0.0900619572430978	8	0.0318417103467637	0.906644475516503	1.03146168648813	1.0756338766292	1.06174572437429	0.9957441196203	0.877384867614564	0.998199144995904	0.861908945201368	0.857846396759341	1.02396157282357	0.76770564008732	0.818874056564417	0.797670433641286	0.782416934851758	0.680475766673659	0.752994345322881	0.716153118544545	0.749617673676882	0.80845225321473	p.Gln149Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.532	-2.826	0.294	9.946	9.946	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.49	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q149V	149	Q	V	missense	possibly_wt-like	0.730989292126604	0.232407816843234	8	0.0821685716453058	0.569941851040706	0.892036733212503	1.01014476265539	0.596908026043182	0.771454057138518	0.424980660063941	0.649425960856744	1.08993345589288	0.512702624735411	0.79236478962677	0.647563844608795	0.787715873894759	0.583388077724105	0.672413321430346	0.482073204204001	0.622714367787244	0.828540172511247	0.563725518468288	0.692133218854651	p.Gln149Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.532	-3.424	0.892	6.814	6.814	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q149W	149	Q	W	missense	possibly_low	0.55027305404249	0.236810865830709	7	0.0895060941065626	0.374844333196775	0.725701774888206	0.751495434621735	0.515764543830928	0.857487467299945	NA	0.121837751267405	0.606024320479731	0.56531723240793	0.433984628389757	0.59003457523257	0.664656596997538	0.545982298033275	0.714608619287076	NA	0.425640214099037	0.59003457523257	0.59206339853011	0.512137479218335	p.Gln149Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.532	-4.354	1.822	13.06	13.06	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q149X	149	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln149Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	1	0	0	4	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q149Y	149	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln149Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	86.9	42.7	0.766	105.3	55.4	-59.6	-27.1	53.2710280373832	-2.5	1	0	41.44	0	0	0	0	6	19.2629529890928	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.532	-3.227	0.695	10.554	10.554	88.09	0.003389483	0	0.096877076	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.82	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E150A	150	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.632	-2.377	0.745	14.807	14.807	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.77	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E150C	150	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.632	-5.443	3.811	1.095	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150D	150	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.632	-1.901	0.269	34.947	34.947	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.565	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
E150F	150	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.632	-4.615	2.983	3.324	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150G	150	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.632	-2.951	1.319	16.32	16.32	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E150H	150	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.632	-3.62	1.988	9.663	9.663	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.845	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150I	150	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.632	-4.304	2.672	4.196	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150K	150	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.632	-2.749	1.117	15.126	15.126	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.38	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
E150L	150	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.632	-3.876	2.244	5.139	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.19	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150M	150	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.632	-3.715	2.083	4.22	4.22	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.19	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150N	150	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.632	-3.242	1.61	7.781	7.781	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.73	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150P	150	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.632	-4.171	2.539	2.033	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150Q	150	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.632	-2.535	0.903	10.989	10.989	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.855	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E150R	150	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.632	-3.317	1.685	9.647	9.647	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150S	150	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.632	-2.964	1.332	8.186	8.186	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150T	150	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.632	-3.06	1.428	7.322	7.322	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150V	150	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.632	-3.445	1.813	6.881	6.881	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E150W	150	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.632	-5.729	4.097	0.696	NA	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E150X	150	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	4	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E150Y	150	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu150Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	90.5	43.8	0.911	111.1	43.4	-71	-43.8	35.981308411215	-3.3	1	0	41.11	0	0	0	0	7	20.5655629113331	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.632	-3.772	2.14	8.033	8.033	88.09	0.003114905	0	0.08902917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151A	151	A	A	synonymous	wt-like	0.920597539749249	0.201558139361634	7	0.0761818159245403	0.77128392426029	1.06991115523821	NA	0.838408542532156	0.944254813756874	0.674266973984874	0.670289911377675	1.08177913081971	1.1865621349908	1.04862127078265	0.757163878007133	NA	0.694715751478337	0.757163878007133	0.591398101375728	0.630507842540415	0.824521128377431	0.926661798426709	0.82083753860004	p.Ala151=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A151C	151	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.333	-3.264	1.931	13.551	13.551	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151D	151	A	D	missense	low	0.24923178368769	0.184645438741292	2	0.130564041849133	-0.00666903601259078	0.505132603387971	0.379795825536823	NA	NA	NA	NA	NA	NA	0.118667741838557	0.420790418272597	0.48781065092565	NA	NA	NA	NA	NA	NA	0.353770185619545	p.Ala151Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.333	-3.914	2.581	2.585	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A151E	151	A	E	missense	low	0.23841746860379	0.178312985906303	8	0.0630431607539841	0.114855144054412	0.361979793153168	0.103059935902433	0.327580100542964	0.297796623811596	0.363917424954076	0.516416076600138	0.0215090754711595	0.0105976577854055	0.266462853762547	0.434053430182184	0.35614621271189	0.45923243673871	0.440106866951982	0.455293828335511	0.573030144569973	0.301942974088821	0.293295100732675	0.427999993412385	p.Ala151Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.333	-3.094	1.761	8.329	8.329	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151F	151	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.333	-4.381	3.048	2.77	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151G	151	A	G	missense	low	0.214107772879334	0.0998772502211271	8	0.0353119404588123	0.144897641355839	0.283317904402829	0.163963959300562	0.225194723707361	0.284702468852123	0.397946054848129	0.0487860808531485	0.197258145260325	0.186451931805737	0.208558818407288	0.398635227996591	0.385122916948794	0.412034501118236	0.433684806409915	0.470217136420696	0.398352651828445	0.388564890877908	0.388009050831174	0.398917804164738	p.Ala151Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.333	-2.727	1.394	13.158	13.158	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A151H	151	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.333	-4.961	3.628	0.994	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151I	151	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.333	-2.851	1.518	8.018	8.018	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151K	151	A	K	missense	low	0.109583789381352	0.175431369792516	4	0.0877156848962582	-0.0623357938945775	0.281503372657282	0.342184307892972	NA	NA	NA	0.0609432268437302	-0.0797074374030171	0.114915060191724	NA	0.376186785081905	0.469915973992033	NA	NA	NA	0.402893805731832	0.252056119117775	0.349479764431977	NA	p.Ala151Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.333	-3.813	2.48	2.609	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151L	151	A	L	missense	low	0.176906923019825	0.16870973894201	7	0.0637662875707413	0.0519272959533481	0.301886550086302	0.181902795973328	0.13783733863199	0.32101284358788	0.338555626568545	-0.165771819811374	NA	0.177905269407245	0.246906406781161	0.393657794213353	0.393657794213353	0.371764216784754	0.451493319107366	0.444171372565767	0.318207159715398	NA	0.3834058749321	0.418177805914833	p.Ala151Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.333	-3.519	2.186	4.949	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151M	151	A	M	missense	low	0.491646236719478	0.0619508681327545	3	0.0357673503929768	0.421543518126819	0.561748955312137	NA	NA	0.494591448865441	NA	0.552071969529405	NA	NA	0.428275291763588	0.536625373474383	NA	NA	0.536625373474383	NA	0.586348969356642	NA	NA	0.509269975991279	p.Ala151Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.333	-4.823	3.49	1.09	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151N	151	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.333	-3.398	2.065	9.824	9.824	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151P	151	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.333	-4.142	2.809	1.402	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A151Q	151	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.333	-4.245	2.912	1.827	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151R	151	A	R	missense	low	0.229636652433873	0.127645968205079	8	0.0451296648544669	0.141184134684755	0.318089170182991	0.219152407086975	0.218729295731268	0.199957025388105	0.244445106531406	0.188587549455667	-0.0129989822920107	0.367416868600457	0.411803948969116	0.410217166074718	0.411380284517878	0.409054047631558	0.392121194991334	0.402899058959729	0.450573788708389	0.284934894832981	0.485475570133238	0.50099727607714	p.Ala151Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.333	-3.477	2.144	7.086	7.086	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151S	151	A	S	missense	possibly_wt-like	0.815132472418077	0.135129518636772	2	0.0955509989665354	0.627855955756843	1.00240898907931	0.910683471384612	0.719581473451541	NA	NA	NA	NA	NA	NA	0.690166499706006	0.740394526972671	0.63993847243934	NA	NA	NA	NA	NA	NA	p.Ala151Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.333	-1.793	0.46	10.587	10.587	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
A151T	151	A	T	missense	possibly_low	0.701714586098561	0.262423889760558	6	0.107134104371625	0.491735600014221	0.911693572182901	1.22151737981888	0.688443284274812	0.49807830042078	0.618846555893261	0.61834298944735	NA	NA	0.565059006736284	0.594536516615921	0.888282001871046	0.625584291270859	0.538335508405495	0.56709339160734	0.611103702170988	NA	NA	0.577969331060855	p.Ala151Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.333	-3.141	1.808	6.712	6.712	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A151V	151	A	V	missense	wt-like	0.970038052845563	0.0799311096547267	8	0.0282599148323114	0.914649637568063	1.02542646812306	0.963469568442621	0.938546157500114	0.872088086944616	0.937657599270236	0.884573964640051	1.06020454587524	1.09778568081157	1.00597881928005	0.753193209590892	0.765508912475115	0.740877506706668	0.721769529143419	0.706908466033983	0.710551042289765	0.813887604660575	0.878847386761734	0.799420450188608	p.Ala151Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.333	-2.579	1.246	8.284	8.284	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
A151W	151	A	W	missense	low	-0.157887561440434	0.166323069365088	3	0.0960266688703783	-0.346096373981729	0.0303212511008615	NA	NA	NA	NA	-0.348369550675429	-0.0838791416981843	-0.0414139919476869	NA	0.25	NA	NA	NA	NA	0.25	0.25	0.265281969833217	NA	p.Ala151Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.333	-5.637	4.304	0.58	NA	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A151X	151	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A151Y	151	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala151Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	91.6	41.7	0.89	113.2	51.9	-67.4	-43.4	0	-4.6	1	0	34.46	0	0	0	0	8	17.8542044868989	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.333	-3.616	2.283	6.695	6.695	31.27	0.002397386	0	0.068521277	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152A	152	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.246	-3.441	2.195	2.749	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152C	152	L	C	missense	low	0.257705422994109	0.157907808215703	7	0.0596835415162903	0.140727831152379	0.374683014835839	NA	0.382318944676816	0.419449885976549	0.186462650532229	0.0910469356623907	0.0331429202310389	0.413337636081667	0.278178987798076	0.433884398966879	NA	0.484466122653811	0.499772008931842	0.377470763518348	0.414138679727276	0.307676978450474	0.510208192094972	0.433884398966879	p.Leu152Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.246	-3.798	2.552	12.712	12.712	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L152D	152	L	D	missense	low	0.296612858618161	0.103904690662473	4	0.0519523453312364	0.19478813285655	0.398437584379772	0.217922351998645	NA	0.200120782992476	0.356444744367495	NA	NA	NA	0.41196355511403	0.431405862968634	0.410795053189947	NA	0.392201510311624	0.452016672747322	NA	NA	NA	0.501077437953303	p.Leu152Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.246	-4.347	3.101	1.065	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152E	152	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.246	-4.134	2.888	1.437	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152F	152	L	F	missense	possibly_low	0.621299399583493	0.174423809686202	3	0.100703633475409	0.423923904859369	0.818674894307616	NA	0.822041345073296	NA	NA	NA	0.535094191067012	NA	0.50676266261017	0.555075051548044	NA	0.687170748902517	NA	NA	NA	0.555075051548044	NA	0.548690105495314	p.Leu152Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.246	-3.415	2.169	10.234	10.234	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152G	152	L	G	missense	low	0.222664810496726	0.129888660598667	8	0.0459225763542778	0.132658214765051	0.312671406228402	0.072276380712964	0.155417743815055	0.258027814787092	0.336828858502485	0.457441647295046	0.0766369933474611	0.215287836257199	0.209401209256509	0.401440385889326	0.341500119985722	0.379868487703681	0.420602156641792	0.44341409576909	0.551000964362189	0.329114019265705	0.403539878446686	0.399340893331965	p.Leu152Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.246	-4.07	2.824	1.412	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152H	152	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.246	-5.178	3.932	0.737	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152I	152	L	I	missense	wt-like	1.10862438193357	0.0901489622955789	4	0.0450744811477894	1.02028002226207	1.19696874160507	1.0453651308248	NA	1.01746764148456	1.19440771456864	NA	NA	NA	1.17725704085627	0.811989761429207	0.804472898055354	NA	0.793071289640671	0.819506624803059	NA	NA	NA	0.885444604175794	p.Leu152Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.246	-1.964	0.718	15.901	15.901	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.295	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L152K	152	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.246	-3.367	2.121	5.569	5.569	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152L	152	L	L	synonymous	wt-like	0.888489337101635	0.236391921377895	8	0.0835771653120135	0.724681103160139	1.05229757104313	0.851672689494754	1.03856059019491	1.12057540097395	1.17248090466127	0.909320553734844	0.428408812169264	0.829518612524743	0.757377133059351	0.727077672837108	0.712318582589932	0.786982476980176	0.843640744168063	0.809890588524438	0.719794829421252	0.5024927418688	0.734360516252965	0.674560736325884	p.Leu152=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L152M	152	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.246	-2.215	0.969	7.797	7.797	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.925	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L152N	152	L	N	missense	low	0.245781439779542	0.148327901826012	2	0.104883665220346	0.0402132333811087	0.451349646177976	NA	0.140897774559197	0.350665104999888	NA	NA	NA	NA	NA	0.419605684986044	NA	0.373175026241409	0.46603634373068	NA	NA	NA	NA	NA	p.Leu152Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.246	-4.4	3.154	1.056	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152P	152	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.246	-3.53	2.284	12.153	12.153	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L152Q	152	L	Q	missense	possibly_wt-like	0.893428549044501	0.190402672633511	4	0.0952013363167555	0.706837358583575	1.08001973950543	NA	1.03155427565794	0.878038517825515	0.629684889597748	1.03443651309681	NA	NA	NA	0.745609152851443	NA	0.783752683891814	0.724687932620909	0.571846559557553	0.766530373081978	NA	NA	NA	p.Leu152Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.246	-4.396	3.15	1.425	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L152R	152	L	R	missense	low	0.182816637518017	0.128661970501948	8	0.0454888759113756	0.0936600790345097	0.271973196001525	0.107097285720247	0.238601806534308	0.241736867055072	0.368819319173165	-0.0565842491241386	0.234703047070551	0.0998293038955032	0.228329719819432	0.407934080671364	0.358067088953628	0.418214940666167	0.412612221212855	0.457443561600124	0.358992847673071	0.407020460359283	0.34135467576411	0.408847700983446	p.Leu152Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.246	-3.284	2.038	9.476	9.476	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L152S	152	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu152Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.246	-3.917	2.671	1.649	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152T	152	L	T	missense	low	0.2192923003988	0.119852192542031	8	0.042374149043273	0.136240494398453	0.302344106399148	0.272245861193011	0.305078341813264	0.220077477985552	0.383822382241298	-0.00897474534835106	0.183430828246183	0.131768778688269	0.266889478371177	0.415101792652083	0.436640903286679	0.448859504658994	0.401989320511042	0.464023178031473	0.37677679828757	0.381749783945893	0.358557065859813	0.428214264793123	p.Leu152Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.246	-3.792	2.546	2.324	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152V	152	L	V	missense	low	0.443232808999198	0.0680906086761783	7	0.0257358310251692	0.392791507077657	0.493674110920738	NA	0.407772150284416	0.481310552165414	0.536668317565998	0.467458757496725	0.467168296572411	0.420226566333007	0.322025022576412	0.521596233208954	NA	0.496199622072689	0.530111724985841	0.531053998535279	0.554742733945959	0.521596233208954	0.513918524412411	0.455905984739945	p.Leu152Val	1	0	NA	NA	NA	NA	NA	NA	NA	3.856	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.246	-2.419	1.173	10.323	8.217	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.375	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L152W	152	L	W	missense	low	0.249043838024677	0.214855630963533	8	0.0759629368152143	0.100159217706965	0.397928458342389	0.338120613011522	0.19745881075885	0.493006060822117	0.531382438788024	-0.132798398117124	0.165577339597434	0.111222650435843	0.288381188900749	0.419128573339812	0.467982563387629	0.399248712032155	0.535847816004779	0.528735868250567	0.330523980024283	0.372950286969994	0.347491056933623	0.439008434647468	p.Leu152Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.246	-5.492	4.246	0.475	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L152X	152	L	X	nonsense	low	-0.0452499642257533	0.0357594145552798	4	0.0178797072776399	-0.0802935465440462	-0.0102063819074604	NA	-0.0813576499638331	-0.000881558587761418	-0.0331050814254559	NA	NA	NA	-0.0656555669259627	0.275949006133072	NA	0.270719015997067	0.293619416948539	0.281178996269076	NA	NA	NA	0.26119416193909	p.Leu152Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L152Y	152	L	Y	missense	low	0.542487533201245	0.0474017364294088	2	0.0335180892692524	0.476793285402912	0.608181780999578	NA	NA	NA	NA	0.576005622470498	NA	0.508969443931993	NA	0.578501973018196	NA	NA	NA	NA	0.595289094083281	NA	0.56171485195311	NA	p.Leu152Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.1	89.6	38.7	0.92	111.4	45.6	-61	-47.2	2.09424083769634	-5.1	1	0	31.71	0	0	0	0	7	15.0966101446649	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.246	-4.313	3.067	2.374	NA	58.56	0.002455765	0	0.07018986	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D153A	153	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.153	-2.523	0.37	12.003	12.003	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.15	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
D153C	153	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.153	-3.782	1.629	18.828	18.828	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D153E	153	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.153	-2.353	0.2	16.217	16.217	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.365	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D153F	153	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.153	-3.716	1.563	11.191	11.191	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D153G	153	D	G	missense	possibly_low	0.602831180030725	0.291836370489264	6	0.119141699347421	0.369317740252881	0.836344619808569	0.63216225936842	0.431642709063605	0.725965659306778	1.08443092337909	NA	0.227433329658712	NA	0.515352199407744	0.580442428976593	0.607880674291055	0.507203547938919	0.650103424706104	0.771276133529932	NA	0.40343741518309	NA	0.553004183662131	p.Asp153Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.153	-3.458	1.305	13.031	13.031	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.835	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D153H	153	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.153	-3.33	1.177	17.658	17.658	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.515	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D153I	153	D	I	missense	low	0.307300030496986	0.160505008246815	5	0.0717800218338084	0.166613772893223	0.44798628810075	0.145037946684649	0.125301675829295	0.397537301256038	0.474239022492923	NA	NA	0.394384206222026	NA	0.489024927799548	0.376118364550503	0.365985487202388	0.489024927799548	0.503675534964543	NA	NA	0.5	NA	p.Asp153Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.153	-3.784	1.631	5.929	5.929	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D153K	153	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.153	-2.882	0.729	11.482	11.482	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.93	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D153L	153	D	L	missense	low	0.470886208872962	0.0325842854459616	3	0.0188125459735776	0.434014296307246	0.507758121438678	NA	0.434210914966295	0.481948708359155	0.496499003293435	NA	NA	NA	NA	0.513437683851835	NA	0.508387447638286	0.530424710262416	0.513437683851835	NA	NA	NA	NA	p.Asp153Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.153	-3.243	1.09	10.343	10.343	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.86	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D153M	153	D	M	missense	possibly_wt-like	0.712512370635199	0.453386077327177	3	0.261762573791674	0.19946715350301	1.22555758776739	NA	0.276672516305464	0.679251782736696	NA	1.18161281286344	NA	NA	NA	0.627192488917104	NA	0.435764897157414	0.627192488917104	NA	0.821506288374033	NA	NA	NA	p.Asp153Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.153	-4.196	2.043	4.702	4.702	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D153N	153	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.153	-2.757	0.604	14.304	14.304	35.98	0.00306418	0	0.087579361	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Nov 17, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.9	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D153P	153	D	P	missense	low	0.203183784462458	0.125379996251985	3	0.0723881745870778	0.0613055693651875	0.345061999559728	NA	0.0598898387181334	0.292727050104766	0.256934464564473	NA	NA	NA	NA	0.408376286173811	NA	0.335831731146513	0.437620482044479	0.408376286173811	NA	NA	NA	NA	p.Asp153Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.153	-4.363	2.21	1.429	NA	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D153Q	153	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.153	-2.823	0.67	8.494	8.494	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.335	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D153R	153	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.153	-2.613	0.46	18.867	18.867	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.62	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D153S	153	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.153	-2.685	0.532	10.041	10.041	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.97	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D153T	153	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.153	-2.838	0.685	9.031	9.031	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.515	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D153V	153	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.153	-3.187	1.034	9.486	9.486	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.285	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D153W	153	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp153Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.153	-5.728	3.575	0.839	NA	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.835	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D153X	153	D	X	nonsense	low	-0.034304237680259	0.0896681929063272	6	0.036606886462992	-0.10605241673387	0.0374439413733521	NA	-0.0952832764147941	0.00475118744050855	-0.0205815145234035	-0.149422660540806	NA	-0.0560525056084524	0.110763343565393	0.291526618471593	NA	0.264299536565326	0.29638201110781	0.286671225835375	0.324314189152748	NA	0.257397763093826	0.349800216945366	p.Asp153Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D153Y	153	D	Y	missense	possibly_low	0.396520130041725	0.359739394505785	5	0.16088034805991	0.0812004420240331	0.711839818059417	NA	0.269475066876158	0.581465748298797	0.697443704588467	-0.17809569382266	NA	NA	0.612311824267863	0.579233087545083	NA	0.432446994100404	0.579233087545083	0.601562292302064	0.313603726589353	NA	NA	0.601701966852241	p.Asp153Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	91.1	38.7	0.877	111.2	54.7	-65.7	-37.2	40.6417112299465	-4.7	1	0	33.49	1	4	0	0	7	17.0324524910537	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.153	-2.867	0.714	9.687	9.687	35.98	0.00306418	0	0.087579361	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F154A	154	F	A	missense	possibly_low	0.636378693870163	0.266697695233435	8	0.0942918744131925	0.451570015985531	0.821187371754794	0.302918771276389	0.713137050355696	0.753554630654253	0.441144438120204	0.619698182797313	1.18823428456834	0.491150618388993	0.581191574800108	0.598840900087857	0.451234353669441	0.636967701848954	0.663634503636757	0.489161853982296	0.611609918150939	0.876989966368131	0.552117750246623	0.586071882024776	p.Phe154Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.993	-3.295	1.302	9.056	9.056	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.24	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F154C	154	F	C	missense	low	0.430474252977152	0.211073884277303	4	0.105536942138652	0.223625647346908	0.637322858607397	NA	0.17833433378667	0.359794993271435	0.672445452818125	NA	NA	NA	0.51132223203238	0.51074713014626	NA	0.390432650004493	0.470514119914302	0.59059927046071	NA	NA	NA	0.550980140378219	p.Phe154Cys	1	0	NA	NA	NA	NA	NA	NA	NA	5.55	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.993	-3.803	1.81	19.428	19.428	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F154D	154	F	D	missense	low	0.219809527619118	0.113983379870084	7	0.0430816681044068	0.135371009740572	0.304248045497663	0.208621262016983	0.313840694041067	0.276582710967091	0.386905792309673	0.181302444637586	0.071706109148821	0.0997076802126022	NA	0.429702451161639	0.406369812976872	0.452898801569488	0.429702451161639	0.465375412269131	0.447852526480656	0.326683721106724	0.341289170052081	NA	p.Phe154Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.993	-3.634	1.641	10.435	10.435	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154E	154	F	E	missense	low	0.276348728602415	0.102241861196984	4	0.0511209305984918	0.176153545773199	0.37654391143163	NA	0.267133291568757	0.26679217226626	0.161220170662562	0.41024927991208	NA	NA	NA	0.428134066221485	NA	0.431367475094738	0.424900657348232	0.36640063506763	0.533372829969685	NA	NA	NA	p.Phe154Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.993	-3.358	1.365	8.329	8.329	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154F	154	F	F	synonymous	possibly_wt-like	0.880716811774761	0.285672985860005	7	0.107974239553549	0.669091190991704	1.09234243255782	0.342831867784733	1.02283612658364	1.02374441536933	0.918859995553096	1.07203451019192	1.13867940199014	NA	0.646031364950484	0.779733763891166	0.470224067783088	0.779733763891166	0.79614974884797	0.698664747952841	0.780574647239768	0.852565718089992	NA	0.618637540641861	p.Phe154=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	NA	NA	NA	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F154G	154	F	G	missense	low	0.3152741579025	0.14764232505737	7	0.055803553584166	0.205901202668184	0.424647113136816	0.513743495109882	0.172242754167614	0.362805690369917	0.482075698646079	0.124643852566154	NA	0.249360521238499	0.302047093219354	0.445872108538166	0.551539806864474	0.387624534318706	0.471990723719597	0.507112321369446	0.426688399082255	NA	0.421891201455575	0.445872108538166	p.Phe154Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.993	-3.978	1.985	2.727	NA	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154H	154	F	H	missense	possibly_wt-like	0.719707496952847	0.194502530557028	8	0.0687670291574092	0.58492659648051	0.854488397425185	0.767640599119782	0.833447114706101	0.34208207393978	0.569619342734665	0.637054672158859	0.913889043563571	0.908326288041197	0.785600841358823	0.680537063069246	0.672338087158834	0.692428616749168	0.461826775012954	0.545504721407333	0.61809322348217	0.741772689449932	0.776805809595003	0.688736038979659	p.Phe154His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.993	-2.583	0.59	13.792	13.792	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.815	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F154I	154	F	I	missense	possibly_low	0.612947692572446	0.393685847668878	7	0.148799263945358	0.321306494313474	0.904588890831417	0.357738420486797	0.253590144233905	0.391306901001323	0.458287335187079	1.26313460334831	NA	1.0848196318449	0.481756811904803	0.49667989791172	0.477316255535873	0.425124312098568	0.485969212653292	0.49667989791172	0.851957760895489	NA	0.871863958456419	0.536130965565772	p.Phe154Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.993	-3.05	1.057	7.681	7.681	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.58	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F154K	154	F	K	missense	low	0.42270127349244	0.201730928502232	5	0.0902168138590279	0.245879567528791	0.599522979456089	0.338495480135467	0.243001420345395	0.512253999259655	0.733685303018453	NA	NA	NA	0.28607016470323	0.468160916362895	0.468160916362895	0.420243088589518	0.545288014806338	0.617456101149323	NA	NA	NA	0.437847727234664	p.Phe154Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.993	-3.35	1.357	5.913	5.913	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154L	154	F	L	missense	low	0.422159163671711	0.207523908174537	7	0.0784366645900042	0.268426126007855	0.575892201335567	0.27387920497998	0.188663369534485	0.57623588408114	0.78430950023596	0.37964971498872	NA	0.273807585696578	0.478568886185115	0.52194273496208	0.437418009907744	0.395194161651119	0.576668087761856	0.639657420861405	0.52194273496208	NA	0.435058228848208	0.534529836067307	p.Phe154Leu	1	0	NA	NA	NA	NA	NA	NA	NA	8.6	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.993	-2.447	0.454	24.134	24.134	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	deleterious	deleterious	low	0.87	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
F154M	154	F	M	missense	possibly_low	0.602007046154263	0.209838246045368	6	0.0856661052219568	0.434104565223409	0.769909527085117	0.804887082871705	0.348756008267891	0.575672463551511	0.575157589897331	0.886258030598564	NA	NA	0.421311101738574	0.562162642505937	0.690059089538084	0.468994173818714	0.57639175677577	0.547933528236104	0.711180104629477	NA	NA	0.505772225082876	p.Phe154Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.993	-3.502	1.509	5.185	5.185	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F154N	154	F	N	missense	low	0.136239452790039	0.283434911744007	2	0.200418748119198	-0.256574075350194	0.529052980930272	NA	NA	NA	NA	-0.0641792953291591	NA	NA	0.336658200909237	0.409705640368904	NA	NA	NA	NA	0.35615581061297	NA	NA	0.463255470124838	p.Phe154Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.993	-3.662	1.669	8.645	8.645	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154P	154	F	P	missense	wt-like	1.32648977263051	0.403344354182168	2	0.285207527995519	0.767493289639591	1.88548625562142	NA	NA	NA	NA	1.61169730062603	NA	1.04128224463499	NA	0.915287061493853	NA	NA	NA	NA	0.982159113626159	NA	0.848415009361547	NA	p.Phe154Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.993	-4.523	2.53	1.185	NA	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154Q	154	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe154Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.993	-4.397	2.404	1.827	NA	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F154R	154	F	R	missense	low	0.340293109283176	0.17856459722811	8	0.0631321187899205	0.216556430187227	0.464029788379124	0.338760687734099	0.405272315397986	0.462271767491381	0.635927815967737	0.199852863468106	0.0327081113346119	0.293640600603254	0.353910712268233	0.470103803171809	0.468287095910947	0.495047240261164	0.5207741061626	0.574584404538751	0.454781809632059	0.307462673020063	0.445740159637996	0.471920510432671	p.Phe154Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.993	-2.867	0.874	9.476	9.476	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F154S	154	F	S	missense	low	0.334437718668211	0.152974844803336	7	0.0578190565997613	0.221114450112596	0.447760987223826	NA	0.104290895625602	0.312730141634672	0.2870801202658	0.353138695131288	0.302710226906362	0.62213108523428	0.358982865879473	0.44743104753963	NA	0.35629987113065	0.44743104753963	0.42159670994231	0.51203986619653	0.440539342023151	0.622662964286904	0.474467989728547	p.Phe154Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.993	-3.327	1.334	8.95	8.95	64.27	0.003228011	0	0.09226192	3.231e-05	1	30946	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.385	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F154T	154	F	T	missense	possibly_low	0.590887910256518	0.231101801623665	4	0.115550900811832	0.364412306284167	0.81736351422887	0.517917755121521	0.779821336838358	0.770055915855199	NA	NA	NA	NA	0.295756633210996	0.610616928705978	0.553525821761626	0.667708035650329	0.67172759959525	NA	NA	NA	NA	0.442712737221548	p.Phe154Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.993	-4.005	2.012	3.342	NA	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F154V	154	F	V	missense	low	0.243647973281668	0.103944360191682	8	0.0367498809788178	0.171619530127052	0.315676416436285	0.205032862501325	0.0656987342557923	0.264077051989833	0.216494807146731	0.240355051867477	0.196885652740276	0.410012981628178	0.350626644123734	0.414115778335079	0.404662536747034	0.338509534228223	0.423569019923123	0.390641412087395	0.469910909100638	0.388381299487553	0.508417555172686	0.470271093588153	p.Phe154Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.993	-3.074	1.081	8.484	8.484	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.035	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F154W	154	F	W	missense	possibly_low	0.444323086018585	0.535353171717805	4	0.267676585858902	-0.0803133817695076	0.968959553806677	0.669537956799136	NA	NA	NA	-0.093285478997411	NA	0.115097726131596	1.08594214014102	0.487620650302444	0.62566315350459	NA	NA	NA	0.345283549995207	NA	0.349578147100297	0.839581872719547	p.Phe154Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.993	-3.345	1.352	18.359	18.359	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F154X	154	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe154Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F154Y	154	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe154Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27	94.5	39.2	0.977	108	47.2	-60	-57	23.6842105263158	-4.8	1	0	34.12	0	0	0	0	7	17.7199017452129	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.993	-1.827	-0.166	17.327	17.327	64.27	0.003228011	0	0.09226192	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	-0.13	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
Y155A	155	Y	A	missense	possibly_low	0.372477389855884	0.49603772662713	2	0.350751640222402	-0.314983192498375	1.05993797221014	NA	NA	NA	NA	0.723229030078286	NA	NA	0.0217257496334818	0.477681932166078	NA	NA	NA	NA	0.650282605935987	NA	NA	0.305081258396169	p.Tyr155Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.228	-3.588	2.36	1.949	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155C	155	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.228	-5.188	3.96	0.523	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Aug 27, 2016)	criteria provided, multiple submitters, no conflicts	0	1	0	0	0	12	1	3	1	0	0	3	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y155D	155	Y	D	missense	low	0.348910787099589	0.196116293192865	2	0.138675160817844	0.0771124663463155	0.620709107852863	NA	NA	0.487585947917433	NA	NA	NA	NA	0.210235626281745	0.466474742973067	NA	NA	0.533189508284544	NA	NA	NA	NA	0.399759977661589	p.Tyr155Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.228	-4.226	2.998	0.836	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y155E	155	Y	E	missense	low	0.103948616676238	0.117889515188232	6	0.0481281930392095	0.0096190916783966	0.19827814167408	0.27604021494327	0.0635001539939776	NA	NA	-0.0833765909702662	0.085024220764954	0.139496299893745	0.143007401431751	0.355851976113743	0.438446167705299	0.337496025728663	NA	NA	0.348984894503001	0.333247854604468	0.362719057724485	0.365994732357431	p.Tyr155Glu	0	0	yes	NA	NA	NA	NA	NA	NA	10.723	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.228	-4.072	2.844	1.087	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155F	155	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.228	-1.372	0.144	12.338	12.338	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.455	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Y155G	155	Y	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.228	-3.197	1.969	12.525	12.525	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155H	155	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.228	-3.498	2.27	7.379	7.379	24.57	0.001817427	0	0.051945077	0	NA	NA	Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Sep 19, 2013)	criteria provided, single submitter	1	0	0	0	0	4	0	0	0	1	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y155I	155	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.228	-3.74	2.512	4.604	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155K	155	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.228	-4.089	2.861	0.944	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155L	155	Y	L	missense	possibly_low	0.687755012627179	0.593524576183325	4	0.296762288091662	0.106111615997821	1.26939840925654	-0.050300507138577	0.491277049869841	NA	NA	1.29068367285724	NA	1.01935983492021	NA	0.685650859881959	0.283180914991074	0.534693975430938	NA	NA	0.862248380472821	NA	0.83660774433298	NA	p.Tyr155Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.228	-2.775	1.547	10.529	10.529	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Deleterious	TOLERATED	effect	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y155M	155	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.228	-4.677	3.449	1.397	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155N	155	Y	N	missense	low	0.276691552411217	0.0724953127918053	3	0.0418551883553349	0.194656890668621	0.358726214153814	NA	0.328688065684745	0.193879192487254	0.307507399061653	NA	NA	NA	NA	0.430555124540887	NA	0.459743190022507	0.389140306879452	0.430555124540887	NA	NA	NA	NA	p.Tyr155Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.228	-4.279	3.051	1.137	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	not provided	Uncertain significance	no assertion criteria provided	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y155P	155	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.228	-4.495	3.267	0.479	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155Q	155	Y	Q	missense	low	0.301099639922355	0.228460434754472	3	0.131901693504673	0.042577071153354	0.559622208691355	NA	0.0874494485279902	0.273912172641038	0.541937298598035	NA	NA	NA	NA	0.428392679063867	NA	0.348536247452778	0.428392679063867	0.533364718287467	NA	NA	NA	NA	p.Tyr155Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.228	-4.404	3.176	0.834	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155R	155	Y	R	missense	low	0.21716018285085	0.0305671643570296	2	0.0216142491984994	0.174797032868917	0.259523332832782	0.238774432049349	NA	NA	NA	NA	0.19554593365235	NA	NA	0.404218485892158	0.420715983247452	NA	NA	NA	NA	0.387720988536865	NA	NA	p.Tyr155Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.228	-4.337	3.109	0.987	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155S	155	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.228	-3.918	2.69	1.27	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y155T	155	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.228	-3.95	2.722	1.4	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155V	155	Y	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.228	-3.102	1.874	7.549	7.549	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.725	Deleterious	DAMAGING	effect	TOLERATED	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y155W	155	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr155Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.228	-4.716	3.488	0.573	NA	24.57	0.001817427	0	0.051945077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.625	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y155X	155	Y	X	nonsense	low	0.216119070805287	0.253910633236607	6	0.103658581949442	0.0129519834958876	0.419286158114687	NA	-0.00469580761877919	0.150977923496559	0.172367754021424	0.503759348689426	0.540314723613172	NA	-0.0660095173700778	0.369694349398033	NA	0.30605883513314	0.368099273865679	0.371289424930387	0.568302377921422	0.557648109467216	NA	0.261016391016271	p.Tyr155Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.3	94.3	36.1	0.936	113.4	50.4	-50.2	-51.2	0	-6.8	1	0	32.61	0	0	0	0	8	14.1689469566372	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G156A	156	G	A	missense	wt-like	1.04244496105226	0.166564397761034	4	0.0832821988805168	0.879214850693148	1.20567507141138	NA	NA	NA	NA	0.996615388853736	1.28221873729517	0.896319501049145	0.994626217011007	0.782028830604373	NA	NA	NA	NA	0.752402752494055	0.923312336400228	0.770339033451268	0.793718627757477	p.Gly156Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.355	-1.736	0.381	14.878	14.878	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.045	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
G156C	156	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.355	-3.862	2.507	13.192	13.192	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156D	156	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.355	-2.766	1.411	34.159	34.159	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.41	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G156E	156	G	E	missense	possibly_wt-like	0.788672013483556	0.287363674875988	6	0.117315729009535	0.558737409804806	1.01860661716231	0.680125950838714	0.959971231873496	0.961913948876082	1.11605829878379	0.312212356208061	NA	NA	0.701750294321193	0.698688185036374	0.630700672450447	0.750754105418245	0.76582484430905	0.785146367757982	0.496752330462686	NA	NA	0.646622264654504	p.Gly156Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.355	-3.238	1.883	7.893	7.445	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G156F	156	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.355	-4.599	3.244	1.221	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156G	156	G	G	synonymous	wt-like	1.13734506867002	0.202946054971656	7	0.0767063987166635	0.987003289801593	1.28768684753845	NA	1.1296109658785	1.19554746932751	1.23717300340887	0.694828543748514	1.17114852500559	1.30751978976909	1.22558718355208	0.868568862092025	NA	0.828955167832645	0.880410979698401	0.838261408134085	0.639673949968997	0.868568862092025	0.991808792109543	0.909718324437635	p.Gly156=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G156H	156	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.355	-4.892	3.537	1.532	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156I	156	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.355	-4.306	2.951	2.206	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156K	156	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.355	-3.272	1.917	7.073	6.119	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156L	156	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.355	-3.87	2.515	3.058	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156M	156	G	M	missense	wt-like	0.988965225190472	0.0835014141292824	2	0.0590444161694818	0.873240296010093	1.10469015437085	NA	NA	0.92992080902099	1.04800964135995	NA	NA	NA	NA	0.75271862712851	NA	NA	0.7501337300893	0.75530352416772	NA	NA	NA	NA	p.Gly156Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.355	-5.06	3.705	0.928	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156N	156	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.355	-2.446	1.091	9.195	9.195	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.805	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G156P	156	G	P	missense	possibly_low	0.500383529518096	0.337534055550893	6	0.137797701151987	0.230304998107789	0.770462060928403	NA	0.433728093385644	0.459972815163805	0.587404936211572	1.11360747852828	0.158943627751779	NA	0.248644226067499	0.513905727174015	NA	0.50816487501528	0.51964657933275	0.553304620837904	0.796103723519869	0.369680711568051	NA	0.419050622274754	p.Gly156Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.355	-4.165	2.81	1.987	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156Q	156	G	Q	missense	wt-like	0.997634167310407	0.319727646342682	7	0.120845691356392	0.760780964565035	1.23448737005578	0.828274319502763	0.984968987571555	0.853765140670249	1.09515797790065	1.65945922740996	NA	0.675198900839468	0.886614617278206	0.73947001166193	0.701186187568154	0.762277650093846	0.712782995025927	0.775980499822968	1	NA	0.651244939146867	0.73947001166193	p.Gly156Gln	0	0	NA	NA	NA	NA	NA	NA	NA	-0.918	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.355	-3.52	2.165	5.68	5.68	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G156R	156	G	R	missense	possibly_wt-like	0.926462522707175	0.36549474584661	4	0.182747372923305	0.568284253508187	1.28464079190616	NA	0.749488041880291	NA	1.4398253217731	0.601234375114075	NA	0.915302352061232	NA	0.717143984377598	NA	0.653724897170637	NA	0.927134894681804	0.604712987539339	NA	0.780563071584559	NA	p.Gly156Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.355	-3.234	1.879	20.147	20.147	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	medium	2.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G156S	156	G	S	missense	wt-like	1.15870452122748	0.261120433550334	6	0.106601970602107	0.949768498166355	1.36764054428861	NA	1.09388045910137	0.966682786792994	1.21401367647368	1.65945922740996	0.983947974282385	1.03424300330451	NA	0.820294427575204	NA	0.812484005537056	0.768163732607875	0.828104849613352	1	0.776302823090683	0.844623720490004	NA	p.Gly156Ser	0	0	NA	NA	NA	NA	NA	NA	NA	-1.647	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.355	-2.355	1	10.041	10.041	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.01	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G156T	156	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.355	-3.741	2.386	3.75	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.605	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G156V	156	G	V	missense	low	0.382472759627867	0.219474033519156	7	0.0829533874182774	0.219887107892446	0.545058411363289	NA	0.47707609763724	0.546848771448929	0.508900910579548	0.204419277347596	-0.0434759422576926	0.495807994662422	0.487732207977027	0.528147575447472	NA	0.528147575447472	0.562255106010479	0.518876559406061	0.45648753795262	0.269913633592176	0.554626182335686	0.539132096632646	p.Gly156Val	1	0	NA	NA	NA	NA	NA	NA	NA	4.435	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.355	-3.899	2.544	3.507	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.96	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G156W	156	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.355	-5.655	4.3	0.301	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G156X	156	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G156Y	156	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly156Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	93	34	0.911	111.2	45.7	-54.7	-50.5	3.09278350515464	-5.4	1	0	33.65	0	0	0	0	11	13.605642133321	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.355	-4.637	3.282	1.051	NA	58.31	0.00267753	0	0.076528274	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E157A	157	E	A	missense	wt-like	0.929805374225448	0.205845405759966	7	0.0778022503094363	0.777315765702782	1.08229498274811	NA	1.06353430585444	0.944708840828046	0.7592581701524	0.917139644928575	1.19629896911556	1.04727014445794	0.58042754424117	0.757386556702155	NA	0.798494939602601	0.757386556702155	0.628671121443986	0.722715555759725	0.880964829134783	0.851640052643466	0.585688149161087	p.Glu157Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.145	-2.782	0.637	12.003	12.003	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.21	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E157C	157	E	C	missense	wt-like	0.998238284962254	0.151100250277622	6	0.0616864188645012	0.87733512565258	1.11914144427193	1.01226036627376	0.945184685274252	0.833013493006799	NA	1.2780083506883	NA	0.997382896298154	0.923579918232252	0.773379095330423	0.788722428419598	0.743937756287051	0.702605298331885	NA	0.857513668165446	NA	0.824771110395232	0.758035762241249	p.Glu157Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.145	-5.474	3.329	0.909	NA	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E157D	157	E	D	missense	wt-like	0.987474886804952	0.0821483736878103	3	0.0474283856621472	0.894516959062267	1.08043281454764	0.908090436841035	NA	NA	NA	1.0721330669919	NA	0.982201156581923	NA	0.78061146193273	0.739160822024245	NA	NA	NA	0.78061146193273	NA	0.816594325691521	NA	p.Glu157Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.145	-2.892	0.747	18.802	18.802	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.305	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E157E	157	E	E	synonymous	possibly_wt-like	0.730490309992067	0.509160565710629	6	0.207863930522978	0.323084492482094	1.13789612750204	NA	1.14140916487991	1.10474380886182	0.878309262584481	-0.00321703082893899	1.08210682713456	0.179589827320572	NA	0.752781901227015	NA	0.834393939013808	0.835876100833988	0.6808811615124	0.37892752246121	0.82468264094163	0.384313166694156	NA	p.Glu157=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E157F	157	E	F	missense	wt-like	0.932423420806924	0.173166903797723	8	0.0612237459762242	0.812427083694895	1.05241975791895	1.15747627514936	0.815278920351881	0.853780934541934	1.0645372302683	1.13188068422309	0.830209726490732	0.664866934344268	0.941356661085822	0.737671232462544	0.857812748027461	0.68405338491457	0.712790741169185	0.762551723755902	0.802929457078774	0.700529439348259	0.64568021025701	0.766964096798632	p.Glu157Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.145	-3.387	1.242	11.669	11.669	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E157G	157	E	G	missense	wt-like	0.998517066054699	0.183267701771879	8	0.0647949173476849	0.871521361671987	1.12551277043741	0.977608716305337	0.597368854237415	1.00908303396691	1.2285428993717	1.11972594045017	1.05293183566498	1.04054750328401	0.962327745157058	0.79367411936624	0.772235987024878	0.583600511766111	0.788959038237927	0.834476662707812	0.798389200494553	0.810303084415774	0.848019282524431	0.777496783025873	p.Glu157Gly	1	0	no	NA	NA	NA	NA	NA	38.4	0.909	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.145	-3.339	1.194	17.459	17.459	85.61	0.002691819	0	0.076936662	4.064e-06	1	246084	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E157H	157	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.145	-3.334	1.189	13.88	13.88	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.76	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E157I	157	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.145	-2.803	0.658	8.961	8.961	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.17	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E157K	157	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.145	-2.518	0.373	15.126	15.126	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
E157L	157	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.145	-2.942	0.797	18.729	18.729	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.91	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E157M	157	E	M	missense	wt-like	1.16572206296407	0.1249497841519	4	0.0624748920759502	1.04327352455719	1.28817060137096	NA	1.32614733348276	1.09386922291109	1.19894620160361	NA	NA	NA	1.04392549385883	0.826019809332288	NA	0.919555125677817	0.830542633377584	0.821496985286992	NA	NA	NA	0.818479093764109	p.Glu157Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.145	-3.112	0.967	5.788	5.788	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.77	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E157N	157	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.145	-2.765	0.62	13.203	13.203	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.41	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E157P	157	E	P	missense	low	0.297155419878406	0.158619571953321	5	0.0709368290899088	0.158121789684712	0.4361890500721	0.437588871783753	0.107671934434483	0.14515432156526	0.368526088627657	NA	NA	NA	0.426835882980878	0.457314964892463	0.515307225283305	0.357858473120152	0.365243073958816	0.457314964892463	NA	NA	NA	0.508547035726983	p.Glu157Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.145	-4.385	2.24	2.116	NA	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E157Q	157	E	Q	missense	wt-like	0.934242856730984	0.163193500996213	8	0.0576976155999979	0.821157608161152	1.04732810530082	0.791809956758283	0.896934775520466	1.08515000937127	0.615318083552425	0.980874233146382	1.01377200457092	1.10507356709529	0.985010223832839	0.76770592462742	0.683837299999152	0.721695359915258	0.826266273627355	0.565545974624161	0.746522835386893	0.791002273125141	0.882772594162266	0.788889013867948	p.Glu157Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.145	-2.699	0.554	18.314	18.314	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	-0.03	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
E157R	157	E	R	missense	wt-like	1.10541866400631	0.121019893121935	5	0.0541217415300813	0.999341999826766	1.21149532818586	0.891810833172712	1.18767965858118	1.15487591910347	1.16031174605849	NA	NA	NA	1.1324151631157	0.855723857898091	0.731415368862517	0.855723857898091	0.860463517744045	0.804553785264005	NA	NA	NA	0.8629228582099	p.Glu157Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.145	-2.915	0.77	17.501	17.501	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E157S	157	E	S	missense	possibly_wt-like	0.773210983235617	0.322535622000231	6	0.131674616295293	0.515133477618712	1.03128848885252	0.803074313661287	0.970077816634688	0.945042142629313	0.583403564084744	NA	0.225462928871256	NA	1.11220513353242	0.722304843708722	0.689196616513655	0.75541307090379	0.757550025391287	0.551549812924743	NA	0.402466258446631	NA	0.852772410120478	p.Glu157Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.145	-2.805	0.66	10.969	10.969	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.36	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E157T	157	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.145	-3.152	1.007	9.946	9.946	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.865	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E157V	157	E	V	missense	possibly_wt-like	0.819219200043829	0.230313471900141	8	0.0814281088896036	0.659623039291	0.978815360796657	1.11641289143845	0.808560657650082	0.850535243268249	1.10742977763854	0.388869606227296	0.717957103236527	0.799316815343676	0.76467150554781	0.696077631383234	0.838275754272887	0.680956378874439	0.711198883892028	0.781362316511397	0.525386713106235	0.645203186967253	0.718094027837894	0.678224320734996	p.Glu157Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.145	-3.003	0.858	12.159	12.159	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.56	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E157W	157	E	W	missense	possibly_wt-like	0.80248967508609	0.249072081332742	4	0.124536040666371	0.558403520602788	1.04657582956939	1.02117740273459	0.451695112594877	0.811519194470192	0.925566990544704	NA	NA	NA	NA	0.696834738815861	0.792964944985472	0.516447368493727	0.692063366688446	0.701606110943276	NA	NA	NA	NA	p.Glu157Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-1.155	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.145	-3.802	1.657	12.444	12.444	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.65	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E157X	157	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E157Y	157	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu157Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	95.7	34.9	0.897	121.5	37.6	-63	-41.4	46.7289719626168	-3.6	1	0	42.68	0	0	0	0	9	16.9637925553221	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.145	-3.897	1.752	6.616	6.616	85.61	0.002691819	0	0.076936662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V158A	158	V	A	missense	wt-like	1.29644608766724	0.149062943495651	3	0.0860615305534123	1.12776858732816	1.46512358800632	NA	1.13881814024129	1.31538658005251	1.43513354270792	NA	NA	NA	NA	0.925077307741765	NA	0.833199520261203	0.939186366637487	0.925077307741765	NA	NA	NA	NA	p.Val158Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.38	-2.477	0.097	24.797	24.797	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.875	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
V158C	158	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.38	-5.349	2.969	1.834	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158D	158	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.38	-4.081	1.701	3.549	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.585	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V158E	158	V	E	missense	wt-like	0.856244018555416	0.127809277564558	5	0.0571580465578982	0.744216305875271	0.96827173123556	0.914119760614069	0.655053490651987	0.889443518400789	0.826600065365762	NA	NA	NA	0.996003257744472	0.730281543235981	0.742029432700057	0.610192158346238	0.730281543235981	0.658204013377577	NA	NA	NA	0.794410243790223	p.Val158Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.38	-2.889	0.509	11.647	11.647	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.04	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V158F	158	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.38	-3.597	1.217	10.139	10.139	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158G	158	V	G	missense	possibly_low	0.628919819276748	0.142171992399122	7	0.0537359621838059	0.523599268721882	0.734240369831614	0.722339397315491	0.701313107255163	0.735319626745331	0.764942161675427	0.519150636712111	0.377471321858263	NA	0.581902483375449	0.631163844686614	0.650784839064233	0.631517063071356	0.654691101068942	0.631163844686614	0.574051606213697	0.477387043998208	NA	0.586428934475421	p.Val158Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.38	-3.879	1.499	6.709	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	0.895	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V158H	158	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.38	-4.989	2.609	1.509	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.585	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V158I	158	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.38	-2.77	0.39	13.071	13.071	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	-0.06	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V158K	158	V	K	missense	possibly_wt-like	1.02634549340456	0.377500236080468	5	0.168823237879629	0.695458027407044	1.35723295940207	NA	1.02020729860483	0.788357178825011	0.967610982082888	1.65945922740996	NA	0.696092780100086	NA	0.720044568230822	NA	0.778521918434952	0.680703499082631	0.720044568230822	1	NA	0.662498244468439	NA	p.Val158Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.38	-2.067	-0.313	13.819	13.819	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-1.385	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158L	158	V	L	missense	wt-like	0.933249795459322	0.145835915190042	7	0.0551207948306226	0.82521502279208	1.04128456812656	1.1241388142153	0.982139770880508	1.05243705920635	0.989092001797507	0.739075364846456	NA	0.891534834082363	0.754330723186777	0.760973428813743	0.841951566916634	0.760973428813743	0.810222126668732	0.729465102533356	0.656201811401036	NA	0.767762043435789	0.673030682886663	p.Val158Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.38	-2.896	0.516	21.99	21.99	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	neutral	0.615	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V158M	158	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.38	-3.05	0.67	7.315	7.315	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158N	158	V	N	missense	possibly_low	0.697434184591428	0.388396052805719	5	0.173695995253237	0.356996289636243	1.03787207954661	NA	0.555403552014206	0.271303241030229	0.462550873457396	1.2085809374686	NA	NA	0.989332318986711	0.56425521369874	NA	0.56425521369874	0.427113122131282	0.49854967919116	0.831579903054044	NA	NA	0.791059777761001	p.Val158Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.38	-3.438	1.058	10.06	10.06	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V158P	158	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.38	-4.328	1.948	2.488	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.585	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V158Q	158	V	Q	missense	wt-like	1.16515311955339	0.145980242230234	2	0.103223619200253	0.962838543567018	1.36746769553977	1.26837673875365	NA	NA	NA	NA	NA	NA	1.06192950035314	0.869049077792245	0.91057658454102	NA	NA	NA	NA	NA	NA	0.82752157104347	p.Val158Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.38	-2.824	0.444	8.706	8.706	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158R	158	V	R	missense	wt-like	0.925691394280388	0.194767097571829	8	0.0688605677225311	0.790727161589245	1.06065562697153	0.751943218464392	1.27766393575026	0.808262448231662	0.696317681768218	1.0592358550293	0.893555854486226	1.06868796715002	0.849864193363023	0.726381599255652	0.664869642035399	0.897205095277337	0.69046608747656	0.601068473258809	0.775793865393862	0.731751015853438	0.863175550435469	0.721012182657866	p.Val158Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.38	-2.067	-0.313	13.745	13.745	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.975	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V158S	158	V	S	missense	wt-like	1.04829910741808	0.181128441471327	3	0.104574554441368	0.843336747013673	1.25326146782248	NA	1.11792085189777	NA	NA	0.842689752071573	NA	1.18428671828489	NA	0.823566222026991	NA	0.823566222026991	NA	NA	0.694905704515339	NA	0.925436274022835	NA	p.Val158Ser	0	0	NA	NA	NA	NA	NA	NA	NA	4.19	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.38	-2.888	0.508	8.186	8.186	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V158T	158	V	T	missense	wt-like	1.02236699762544	0.106647826154545	8	0.0377057005363414	0.948465182562355	1.09626881268852	0.952403118637188	0.963883698375642	0.940159750378285	0.925507024994796	1.19229806653246	1.16512466767456	1.07405448921684	0.965505165193714	0.769668195787999	0.760243755510551	0.752557686630648	0.755155444089686	0.701579812958944	0.825497634817136	0.865599867325203	0.866065923763451	0.779092636065447	p.Val158Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.38	-2.901	0.521	13.424	13.424	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	-0.06	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V158V	158	V	V	synonymous	wt-like	1.14503648124804	0.109588407762225	4	0.0547942038811124	1.03764181507951	1.25243114741656	NA	1.15374194631087	1.07215303494521	1.29666974994654	NA	NA	NA	1.05758119378954	0.83270839310951	NA	0.840079143698207	0.819891875517188	0.864353798024959	NA	NA	NA	0.825337642520812	p.Val158=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V158W	158	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.38	-5.699	3.319	0.88	NA	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V158X	158	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V158Y	158	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val158Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.4	98.5	34.4	0.867	123.5	40	-80.9	-36.5	15.7575757575758	-3.3	1	0	38.87	0	0	0	0	8	16.7592505160583	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.38	-3.605	1.225	10.16	10.16	85.61	0.002547888	0	0.072822893	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.585	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R159A	159	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-0.934	-3.321	2.387	3.37	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159C	159	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-0.934	-5.269	4.335	0.511	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159D	159	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-0.934	-3.901	2.967	2.462	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159E	159	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-0.934	-3.478	2.544	4.161	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159F	159	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-0.934	-4.407	3.473	1.714	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159G	159	R	G	missense	wt-like	0.923288945760368	0.145424054043766	7	0.0549651259495176	0.815559278493605	1.03101861302713	NA	1.00227520155018	0.745083472652432	0.970044867907175	0.748700914548226	0.917567974745333	0.919048364229417	1.16030182468981	0.743585934157752	NA	0.770255523482042	0.659479803335937	0.721111952610184	0.659797318326289	0.743585934157752	0.782580648988022	0.876928879800756	p.Arg159Gly	1	0	NA	NA	NA	NA	NA	NA	NA	6.977	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-0.934	-3.594	2.66	2.557	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Sep 24, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R159H	159	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-0.934	-4.564	3.63	1.196	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159I	159	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-0.934	-3.29	2.356	6.67	6.67	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159K	159	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-0.934	-2.428	1.494	16.226	16.226	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	5	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.765	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
R159L	159	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-0.934	-3.554	2.62	4.117	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159M	159	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-0.934	-4.702	3.768	0.915	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jul 2, 2015)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R159N	159	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-0.934	-3.749	2.815	2.457	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159P	159	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-0.934	-4.119	3.185	1.588	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159Q	159	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-0.934	-3.099	2.165	4.937	4.937	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159S	159	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-0.934	-2.801	1.867	6.167	6.167	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	10	2	0	0	0	1	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R159T	159	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-0.934	-3.654	2.72	2.363	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R159V	159	R	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-0.934	-3.851	2.917	4.331	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R159W	159	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-0.934	-3.212	2.278	13.06	13.06	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R159X	159	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R159Y	159	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg159Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.2	97.1	31.4	0.9	118.2	36.2	-81.1	-39.3	4.52830188679245	-4.5	1	0	34.46	3	133	1	135	8	13.3042759239276	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-0.934	-4.309	3.375	1.791	NA	58.56	0.000789484	0	0.022564775	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T160A	160	T	A	missense	possibly_wt-like	0.804983035338931	0.513346393294862	5	0.229575486282331	0.355023350492293	1.25494272018557	1.34471905457528	0.967978585371411	1.10562456296317	NA	0.570177962764406	0.0364150110203845	NA	NA	0.754445360620555	0.946898465804319	0.754445360620555	0.836308068851705	NA	0.593112242736556	0.309289702639689	NA	NA	p.Thr160Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.413	-3.009	1.596	7.116	7.116	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.165	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
T160C	160	T	C	missense	possibly_low	0.679061123269591	0.40414194655786	5	0.180737773012492	0.324821597519131	1.03330064902005	NA	0.885702656297864	1.01733795695402	0.984195621325204	0.398583841931707	0.109485539839155	NA	NA	0.716517541985251	NA	0.716517541985251	0.793007685543341	0.727317787330894	0.529015347608255	0.345304170737114	NA	NA	p.Thr160Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.413	-2.99	1.577	14.271	14.271	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T160D	160	T	D	missense	wt-like	0.963155156378487	0.153198191812216	5	0.0685123141844332	0.828873488079505	1.09743682467747	NA	1.07467913856724	1.12270912784416	0.728041832095145	0.939756526249798	0.950589157136088	NA	NA	0.759861173149119	NA	0.803632519920581	0.844687235765507	0.614981148278152	0.731163816476006	0.759861173149119	NA	NA	p.Thr160Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.413	-3.957	2.544	2.471	NA	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.715	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T160E	160	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr160Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.413	-3.185	1.772	8.108	8.108	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.715	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T160F	160	T	F	missense	possibly_wt-like	1.01503359588672	0.48435440148291	6	0.197736856384045	0.627476478957826	1.40259071281562	1.2888493507282	1.31596063967823	1.16292636833586	1.24000914705472	0.0482807314813156	NA	NA	1.03417533804202	0.851958541847014	0.920316972598236	0.914859231271493	0.864411880392971	0.839505203301058	0.398163884721901	NA	NA	0.813582096950004	p.Thr160Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-1.489	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.413	-2.473	1.06	10.808	10.808	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T160G	160	T	G	missense	wt-like	0.91396946836862	0.203057685231952	8	0.0717917330997783	0.773260257105343	1.0546786796319	0.645096754438643	1.10909995309744	1.06940841999124	1.01482970785502	0.723285324920431	0.862965928707946	1.17070705663965	0.716362601298598	0.72871324502035	0.614034603328772	0.819499936131872	0.818545772354854	0.740752413191999	0.650303634189027	0.716674076848701	0.918122357983056	0.653961267441691	p.Thr160Gly	0	0	NA	NA	NA	NA	NA	NA	NA	3.679	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.413	-3.249	1.836	13.79	13.79	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.745	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T160H	160	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr160His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.413	-4.979	3.566	1.158	NA	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T160I	160	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr160Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.413	-3.053	1.64	7.614	7.614	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T160K	160	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr160Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.413	-3.179	1.766	7.288	7.288	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T160L	160	T	L	missense	possibly_wt-like	0.816084649828908	0.191536275196181	8	0.0677182995172162	0.683359221680868	0.948810077976948	0.530332326383878	0.733479086887175	0.963779383137613	0.690791082167799	0.728081002806085	1.15802781223206	0.831195193992905	0.892991311023745	0.693679256621379	0.559432383259965	0.646345038342462	0.766739751135942	0.598644774486414	0.652095001288402	0.862102021092836	0.735263511954356	0.742672693705491	p.Thr160Leu	0	0	NA	NA	NA	NA	NA	NA	NA	1.247	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.413	-3.132	1.719	10.902	10.902	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
T160M	160	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr160Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.413	-4.829	3.416	1.447	NA	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.815	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T160N	160	T	N	missense	possibly_wt-like	0.789245039509896	0.148045788705455	4	0.0740228943527276	0.644162832547137	0.934327246472656	NA	0.632241880941932	0.805482917096193	NA	0.735266162587762	NA	0.983989197413699	NA	0.671940894925695	NA	0.599676390179234	0.689102859587033	NA	0.654778930264357	NA	0.81755735266973	NA	p.Thr160Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.413	-3.438	2.025	8.724	8.724	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T160P	160	T	P	missense	wt-like	0.993728828306487	0.126370556150711	4	0.0631852780753555	0.869887958925642	1.11756969768733	1.15294286020031	0.898535144537581	0.886060526732438	1.03737678175562	NA	NA	NA	NA	0.739631406921493	0.855655855644455	0.722433103098643	0.728622346642181	0.750640467200806	NA	NA	NA	NA	p.Thr160Pro	1	0	NA	NA	NA	NA	NA	NA	NA	7.569	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.413	-3.522	2.109	13.136	13.136	25.56	0.001431845	0	0.040924517	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Jan 12, 2017)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T160Q	160	T	Q	missense	wt-like	0.841547438079659	0.00383759283035894	2	0.00271358791377968	0.836228903499768	0.846865972659551	NA	NA	NA	NA	0.83883385016588	NA	0.844261025993439	NA	0.7178830310182	NA	NA	NA	NA	0.693465379293968	NA	0.742300682742431	NA	p.Thr160Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.413	-4.328	2.915	1.778	NA	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T160R	160	T	R	missense	wt-like	1.06865979402541	0.128932181308069	7	0.0487317839620345	0.973147252557434	1.16417233549338	NA	0.986643286899218	0.944498782273414	1.24888239522391	0.999236120266751	0.94614942397295	1.20546066523707	1.14974788430454	0.763049473906179	NA	0.763049473906179	0.757283532966802	0.843396579961166	0.753381694812849	0.757672949922194	0.936840421952647	0.871628183748922	p.Thr160Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.413	-3.541	2.128	7.854	7.854	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T160S	160	T	S	missense	wt-like	1.30945264229915	0.070443058318682	3	0.0406703186828316	1.22974028244104	1.38916500215727	NA	1.275278549552	1.26261533491009	1.39046404243537	NA	NA	NA	NA	0.905487429552313	NA	0.896105472384934	0.913304579516915	0.905487429552313	NA	NA	NA	NA	p.Thr160Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.413	-2.329	0.916	5.839	5.839	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
T160T	160	T	T	synonymous	wt-like	1.1760051440466	0.300882244250115	7	0.113722798885828	0.953112554009286	1.39889773408392	NA	1.18357683094216	1.20000108557777	1.3251676228103	1.65945922740996	0.724110045506085	1.24281696335651	0.89690423272343	0.87685158409047	NA	0.853832523405282	0.882595266754631	0.87685158409047	1	0.648235804174963	0.956960277302535	0.744637951026217	p.Thr160=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T160V	160	T	V	missense	wt-like	1.06287481843396	0.203688798000334	5	0.091092399716794	0.884336995723713	1.2414126411442	NA	0.989795008159163	0.844250115190217	1.07556219153419	1.39438968336451	NA	1.0103770939217	NA	0.767386737510803	NA	0.764502364364935	0.708116327350067	0.767386737510803	0.900986498348897	NA	0.831769699381158	NA	p.Thr160Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.413	-2.898	1.485	7.415	7.415	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.025	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
T160W	160	T	W	missense	possibly_wt-like	0.732900066714186	0.128753864774185	5	0.0575804788001788	0.620044402053264	0.845755731375109	NA	0.645665627895532	0.823672712696134	0.807477908042056	0.549191087978968	NA	NA	0.83849299695824	0.649817961812071	NA	0.605864511609102	0.69802408962839	0.649817961812071	0.58527285112066	NA	NA	0.715301021358189	p.Thr160Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.413	-5.446	4.033	0.675	NA	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.715	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T160X	160	T	X	nonsense	low	-0.00447995262432374	0.0666555724848874	4	0.0333277862424437	-0.0698012133439628	0.0608413080953154	NA	-0.0499883692355576	-0.0646757364016789	0.0163748142987666	NA	NA	NA	0.0803694808411749	0.294029103639658	NA	0.285179726481642	0.26233140535708	0.302878480797674	NA	NA	NA	0.334534958448447	p.Thr160Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T160Y	160	T	Y	missense	wt-like	0.865596481716048	0.213265447829152	8	0.0754007221763896	0.717813781842014	1.01337918159008	0.886439761986594	0.795466841084306	0.990034659439728	0.921489218517589	0.376109492567462	1.00564270834825	0.899446454915275	1.05014271686918	0.750441564727235	0.728859939311038	0.674920349800775	0.779616716047595	0.699817797736096	0.52062032796955	0.786995565028202	0.772023190143432	0.821601681940779	p.Thr160Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.3	95.6	29.4	0.686	64.6	-136	-113.5	166.6	7.36196319018405	-3.8	0	0	41.85	2	4	0	0	10	13.3371150501148	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.413	-3.357	1.944	7.797	7.797	25.56	0.001431845	0	0.040924517	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.37	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R161A	161	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.627	-3.122	0.495	7.475	7.475	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R161C	161	R	C	missense	wt-like	1.1566374316592	0.116079043744595	7	0.0438737545963409	1.07064645278383	1.24262841053458	1.36437435243655	1.16880579572375	1.00843469874864	1.11855812714354	1.19570221673621	NA	1.19086767807427	1.04971915275147	0.826769213689138	0.956249994997899	0.847023324759601	0.788641060633707	0.786242671337902	0.826769213689138	NA	0.92898073548426	0.821388947685656	p.Arg161Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.627	-4.316	1.689	15.47	15.47	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.34	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R161D	161	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.627	-2.568	-0.059	13.88	13.88	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.555	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R161E	161	R	E	missense	possibly_wt-like	0.808455315451537	0.631599292956453	6	0.257849331607656	0.303079912062805	1.31383071884027	1.19714745165773	1.32335059687768	1.21925926545845	1.11487826557929	0.0313285613617979	-0.0352322482257282	NA	NA	0.830658112331574	0.876687362285675	0.91826587717072	0.892040488497199	0.784628862377473	0.391831607922003	0.273976725245111	NA	NA	p.Arg161Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.627	-3.009	0.382	11.057	11.057	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.265	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
R161F	161	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.627	-3.089	0.462	16.069	16.069	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.085	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R161G	161	R	G	missense	wt-like	1.00095939727666	0.247121502584013	8	0.0873706451270821	0.82971607952155	1.17220271503177	0.880682105346773	1.042490772825	1.19727464922008	1.0714838875357	1.12555069853929	1.20713467776355	1.0374507163557	0.445607670627197	0.794679596503491	0.726120581478156	0.788794225029406	0.881258079329605	0.765598191006755	0.800564967977576	0.886305454003998	0.846351373545658	0.517975129598118	p.Arg161Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-2.041	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.627	-3.519	0.892	11.26	11.26	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.265	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
R161H	161	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.627	-2.955	0.328	29.605	29.605	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.01	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R161I	161	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.627	-3.152	0.525	23.245	23.245	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.265	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
R161K	161	R	K	missense	possibly_low	0.342162345752662	0.778077727015988	2	0.550184037063221	-0.736178551760101	1.42050324326542	NA	NA	NA	NA	-0.208021691310559	NA	NA	0.892346382815883	0.522387007132278	NA	NA	NA	NA	0.302425234498345	NA	NA	0.74234877976621	p.Arg161Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.627	-2.484	-0.143	15.194	15.194	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.425	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
R161L	161	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.627	-2.965	0.338	20.5	20.5	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
R161M	161	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.627	-3.222	0.595	7.677	7.677	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R161N	161	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.627	-2.912	0.285	15.797	15.797	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.335	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R161P	161	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.627	-4.416	1.789	1.524	NA	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.545	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R161Q	161	R	Q	missense	wt-like	1.29072018787556	0.145523662767339	4	0.0727618313836696	1.14810961891439	1.43333075683673	NA	1.28048030463272	1.18906425545188	1.49969144145723	NA	NA	NA	1.19364474996041	0.896089346582683	NA	0.898503393933904	0.877231271489252	0.953389273735332	NA	NA	NA	0.893675299231462	p.Arg161Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.627	-2.852	0.225	8.865	8.865	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R161R	161	R	R	synonymous	wt-like	0.992100769485193	0.180519440971064	5	0.0807307482543118	0.833871410461772	1.15033012850861	NA	1.17831784241161	1.01510143956303	1.02479970885805	0.691125506927525	NA	NA	1.05115934966575	0.791910780081874	NA	0.851408218199154	0.791910780081874	0.745124772497712	0.638290725639286	NA	NA	0.822112283787502	p.Arg161=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R161S	161	R	S	missense	wt-like	1.31676024731057	0.0468695734867849	2	0.0331417932438268	1.2518035261696	1.38171696845154	1.3499020405544	NA	NA	NA	NA	NA	NA	1.28361845406674	0.944114413063813	0.949364408830758	NA	NA	NA	NA	NA	NA	0.938864417296869	p.Arg161Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.627	-2.72	0.093	7.749	7.749	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
R161T	161	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.627	-2.738	0.111	11.838	11.838	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	0.995	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
R161V	161	R	V	missense	possibly_wt-like	0.885353477556108	0.423756512797264	6	0.172997871922411	0.54628387918611	1.22442307592611	1.29774469435342	0.983636572488112	1.07163454184127	0.894243117770888	NA	0.0664730452856042	NA	0.998388893597355	0.778635926963149	0.924549168222306	0.761663429164337	0.819637579297658	0.687868978261761	NA	0.324104486843604	NA	0.795608424761961	p.Arg161Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.627	-2.852	0.225	15.091	10.489	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.995	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R161W	161	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.627	-4.367	1.74	15.278	15.278	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R161X	161	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R161Y	161	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg161Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.7	96.5	28.7	0.555	106.3	44.8	-94.8	-10.3	54.3396226415094	-0.6	0	0	50.41	1	147	0	0	5	16.4543239867215	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.627	-3.076	0.449	10.002	10.002	85.61	0.003038	0	0.086831087	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.37	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D162A	162	D	A	missense	possibly_low	0.706731474211474	0.209783312864918	5	0.0938179496222124	0.522851671848544	0.890611276574403	NA	0.747522746765973	0.744731431718092	0.938941849744231	0.363287101568224	NA	NA	0.739174241260848	0.659307143992848	NA	0.652818929197986	0.659307143992848	0.707471676058649	0.515830679890794	NA	NA	0.665418369288931	p.Asp162Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.713	-3.261	1.548	7.978	7.978	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.015	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D162C	162	D	C	missense	possibly_wt-like	0.785385038424023	0.158393148188278	7	0.0598669827832551	0.668047908305764	0.902722168542283	NA	0.943317992599675	0.791191370833557	0.963012182619672	0.634213660192408	0.657315055668379	0.916830863718732	0.591814143335739	0.682093535531952	NA	0.743077242379685	0.682093535531952	0.718027757638529	0.617031998043978	0.615314377856231	0.781386317864241	0.591407046431781	p.Asp162Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.713	-5.462	3.749	0.59	NA	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162D	162	D	D	synonymous	possibly_wt-like	0.857115497132103	0.285566335905797	5	0.12770914783418	0.606810166880809	1.1074208273834	1.02622690335688	NA	0.851420553366027	0.986454271026377	0.365788537694967	NA	NA	1.05568722021627	0.72830832163839	0.795367378813525	NA	0.711633086409413	0.72830832163839	0.516765060907509	NA	NA	0.82438639797369	p.Asp162=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D162E	162	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Glu	1	0	NA	0.608970385447002	-0.506652388451289	0.552081272036472	0.665859498857532	0.681661929	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.713	-2.646	0.933	8.624	8.624	54.84	0.002585685	0	0.073903191	0	NA	NA	Cowden syndrome	Likely pathogenic(Last reviewed: Nov 20, 2015)	criteria provided, single submitter	0	1	0	0	0	0	1	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.72	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D162F	162	D	F	missense	possibly_low	0.66831230814912	0.249390452240705	8	0.088172839971291	0.495496717390776	0.841127898907464	1.041910324468	0.567373641886881	0.731146293001714	0.900703203607266	0.20437601997985	0.699107761523747	0.566383969617414	0.635497251108095	0.624629831822761	0.802829182313581	0.56977322367871	0.65264427925824	0.690702058861631	0.456471379689444	0.635912861212856	0.592637936143087	0.613346802432666	p.Asp162Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.713	-3.599	1.886	10.808	10.808	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162G	162	D	G	missense	possibly_wt-like	0.826814522876623	0.16889866162725	6	0.0689525898709592	0.691669930088782	0.961959115664464	0.518474621589943	0.912267935696124	0.86074223180888	0.917822463068192	0.761712576401321	NA	NA	0.989867308695278	0.707207331518669	0.553790765751442	0.728763688705913	0.716204926554803	0.698209736482535	0.664657666228627	NA	NA	0.791328475302625	p.Asp162Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.713	-3.298	1.585	12.525	12.525	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D162H	162	D	H	missense	wt-like	0.931354204869765	0.146681404775869	3	0.0846865485324603	0.765371619771139	1.09733678996839	NA	1.0553272561389	0.76942546379904	0.96930989467135	NA	NA	NA	NA	0.720789628964867	NA	0.794711627804764	0.671418392831923	0.720789628964867	NA	NA	NA	NA	p.Asp162His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.713	-3.481	1.768	9.4	9.4	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D162I	162	D	I	missense	low	0.532463161144267	0.0925296205358861	7	0.03497290926359	0.463917518553043	0.60100880373549	NA	0.682465467898562	0.508803281378821	0.628391249218936	0.448101889962066	0.509497404843569	0.524273520235051	0.42570931447286	0.547512211697524	NA	0.622828618525421	0.543595601724861	0.571279231575659	0.547512211697524	0.542459094667163	0.569957526334194	0.507981218882792	p.Asp162Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.713	-3.47	1.757	6.67	6.67	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162K	162	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.713	-2.336	0.623	8.182	8.182	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.5	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D162L	162	D	L	missense	low	0.556688836914246	0.137454419828712	8	0.0485974761824723	0.461439533857057	0.651938139971435	0.397483220905114	0.54707320901013	0.507661269012256	0.865109986865912	0.502134353819034	0.593667653784257	0.486412220107954	0.553968781809314	0.56405522331875	0.496225898321668	0.56041506576986	0.543035498947662	0.675092598803211	0.567695380867641	0.583944311679142	0.549565680239582	0.572399287139972	p.Asp162Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.713	-3.115	1.402	10.343	10.343	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162M	162	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.713	-4.044	2.331	3.256	3.256	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.475	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162N	162	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.713	-2.087	0.374	17.369	17.369	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.195	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D162P	162	D	P	missense	low	0.423868057841603	0.167706854199332	2	0.118586653855811	0.191442487237096	0.656293628446111	0.305281403985792	NA	NA	NA	NA	NA	NA	0.542454711697415	0.509487403316885	0.452358438835265	NA	NA	NA	NA	NA	NA	0.566616367798505	p.Asp162Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.713	-4.272	2.559	1.057	NA	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.62	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D162Q	162	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.713	-3.427	1.714	5.892	5.892	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.475	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D162R	162	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.713	-2.954	1.241	10.159	10.159	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.475	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D162S	162	D	S	missense	wt-like	1.14615766325289	0.192037294669132	4	0.0960186473345662	0.95796457263289	1.3343507538729	0.868553919660192	1.27030154798941	1.16638776561363	1.27938741974834	NA	NA	NA	NA	0.861442068345935	0.720350275512112	0.893811158425322	0.866109531210972	0.856774605480898	NA	NA	NA	NA	p.Asp162Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.713	-2.92	1.207	6.658	6.658	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.965	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D162T	162	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.713	-2.856	1.143	7.322	7.322	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.015	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D162V	162	D	V	missense	possibly_low	0.557464267926473	0.346993532919647	5	0.155180225472229	0.2533166148881	0.861611920964846	0.468758264800593	1.00343897115265	0.640994535656926	NA	0.629234842364567	NA	NA	0.0448947256576296	0.608429127884681	0.530136890587823	0.770792001683054	0.608429127884681	NA	0.615172221248448	NA	NA	0.31671783158618	p.Asp162Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.713	-3.318	1.605	7.415	7.415	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D162W	162	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.713	-4.201	2.488	11.089	11.089	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.165	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D162X	162	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp162Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D162Y	162	D	Y	missense	possibly_low	0.596431242999419	0.170696158032283	7	0.0645170834153714	0.469980083117724	0.722882402881113	NA	0.417968056344582	0.763570948041942	0.860970579609171	0.599874611676054	0.45022386273456	0.447479764728686	0.634930877860937	0.604205064458623	NA	0.500899763173823	0.668547031163076	0.673277255371086	0.604205064458623	0.513244784523044	0.528596917003395	0.613062342569764	p.Asp162Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	92.9	29.2	0.114	111.6	-111.3	-119.3	20.7	41.1764705882353	-0.6	0	0	52.42	0	0	0	0	5	16.1546401340296	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.713	-4.552	2.839	2.507	NA	54.84	0.002585685	0	0.073903191	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.615	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K163A	163	K	A	missense	wt-like	0.984002915891013	0.125926343500256	8	0.0445216857095287	0.896742015369325	1.0712638164127	1.24008905994262	1.05606741604313	0.947679155632545	0.941309994568796	0.927742895267401	0.996069891352781	0.80160933841059	0.961455575910246	0.767951046314124	0.89711797118969	0.795052829064045	0.758843354911931	0.708510229621262	0.726676270857006	0.782277384964926	0.719328765614777	0.777058737716316	p.Lys163Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.172	-2.667	0.495	12.722	12.722	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K163C	163	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys163Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.172	-4.267	2.095	14.631	14.631	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K163D	163	K	D	missense	possibly_low	0.543118485591561	0.249833679875385	6	0.101994172709422	0.343213580448136	0.743023390734987	NA	0.217817304687448	0.615468615527299	0.447217424232142	0.972075468027604	NA	0.551125581033617	0.455006520041258	0.553557776159888	NA	0.408633635108764	0.595909877503744	0.491825171401413	0.743236163778682	NA	0.584419868865733	0.522695683454043	p.Lys163Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.172	-3.243	1.071	10.435	10.435	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.715	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K163E	163	K	E	missense	wt-like	0.838452111371444	0.046176647859338	4	0.023088323929669	0.793199828005899	0.88370439473699	NA	0.837001689767931	0.773750946326049	0.868327300578519	NA	0.874728508813279	NA	NA	0.68528538636058	NA	0.69406721603074	0.67353983638808	0.67650355669042	NA	0.722471531346363	NA	NA	p.Lys163Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.172	-2.652	0.48	16.29	16.29	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K163F	163	K	F	missense	possibly_low	0.618539643338961	0.447481254749632	6	0.182683457266162	0.260486646526022	0.9765926401519	NA	0.84081560862756	1.03523157008805	0.895188095319258	-0.0381855053991917	NA	0.144983607224907	0.833204484173187	0.69205438403023	NA	0.695825368438457	0.801783652164988	0.688283399622004	0.365865474435034	NA	0.365674485197796	0.712644876087658	p.Lys163Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.172	-3.374	1.202	11.095	11.095	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K163G	163	K	G	missense	wt-like	1.0217747569718	0.152872034656508	7	0.0577801980167954	0.90852764983929	1.13502186410431	0.991587275181898	1.07955122476894	1.03906904679929	NA	0.812670266373979	1.31168253897049	0.95826420719604	0.959598739511976	0.80366575206717	0.778886657105842	0.805878469664503	0.80366575206717	NA	0.683692291041574	0.937834239589085	0.803702042906386	0.776126145243182	p.Lys163Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.172	-2.152	-0.02	24.544	24.544	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	-0.41	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K163H	163	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys163His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.172	-3.635	1.463	18.185	18.185	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K163I	163	K	I	missense	possibly_low	0.508090674313716	0.259346976739979	4	0.129673488369989	0.253935307358863	0.762246041268569	NA	0.691417894798354	0.674015133308605	0.533032366201089	NA	NA	NA	0.133897302946816	0.577041803885579	NA	0.626955536660829	0.624624161310713	0.529459446460446	NA	NA	NA	0.361419203094607	p.Lys163Ile	1	0	NA	NA	NA	NA	NA	NA	NA	2.996	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.172	-4.331	2.159	5.254	NA	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.935	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K163K	163	K	K	synonymous	wt-like	1.26857496540127	0.217186423057775	5	0.0971287211494424	1.07820617008393	1.45894376071861	NA	1.24071234927924	1.12671792605069	1.19747023790699	1.64756591709553	NA	NA	1.13040839667391	0.86191496366373	NA	0.880171035793099	0.846653360716902	0.820849699133074	0.995557398701931	NA	NA	0.86191496366373	p.Lys163=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K163L	163	K	L	missense	possibly_wt-like	0.775679141219539	0.147827898365154	3	0.085348476914858	0.608399200331069	0.942959082108008	NA	0.691513868233248	0.946370652415853	NA	NA	NA	NA	0.689152903009514	0.640295249345378	NA	0.626999778799124	0.758201596287332	NA	NA	NA	NA	0.640295249345378	p.Lys163Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.172	-3.101	0.929	17.145	17.145	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.31	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K163M	163	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys163Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.172	-3.688	1.516	8.239	8.239	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.24	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K163N	163	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys163Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.172	-2.6	0.428	10.61	10.61	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K163P	163	K	P	missense	low	0.511027030436056	0.186793878015517	8	0.0660416089144525	0.38158785548265	0.640466205389462	0.917869736232417	0.317111981077858	0.501205460867298	0.480495188392694	0.311473188753954	0.516965210016554	0.519036615163836	0.524058862983838	0.543004501918826	0.743813583045562	0.454406809839131	0.539869231946606	0.506419186161931	0.496476223457631	0.546139771891045	0.567136963863654	0.557377088525877	p.Lys163Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.172	-4.356	2.184	1.635	NA	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.735	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K163Q	163	K	Q	missense	wt-like	1.02714639159978	0.0508432843380783	3	0.0293543838990742	0.969612856369228	1.08467992683032	NA	NA	NA	NA	1.06016043084749	NA	1.05268214152902	0.968596602422815	0.780645304406994	NA	NA	NA	NA	0.776139229436459	NA	0.854554918508279	0.780645304406994	p.Lys163Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.172	-2.989	0.817	10.139	10.139	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K163R	163	K	R	missense	wt-like	0.90612654711533	0.261411978966252	8	0.0924230915052159	0.724980616425257	1.0872724778054	1.32670330362455	1.19460949090896	0.75585980171539	0.584773523603065	0.782301818121499	1.07066857517957	0.842234755269522	0.691861108500078	0.706778936785731	0.938326994532337	0.858918393975176	0.664765080459795	0.552150610782893	0.672348526853136	0.819045038931866	0.741209346718326	0.641655440290877	p.Lys163Arg	1	0	NA	NA	NA	NA	NA	NA	NA	1.395	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.172	-2.742	0.57	30.306	30.306	88.09	0.002785651	0	0.079618553	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Sep 3, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K163S	163	K	S	missense	possibly_low	0.661048671010073	0.275773724418174	8	0.0975007353045804	0.469950741346923	0.852146600673224	0.352661720580439	0.98209401127039	0.741918580893076	0.638426729336907	0.850391209413287	0.233878202598497	0.962313384601542	0.526705529386447	0.61680394061384	0.474900880927131	0.760952334403592	0.657927574379538	0.575680306848143	0.697782490160275	0.406613917045524	0.805882903103622	0.558706371584024	p.Lys163Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.172	-2.398	0.226	8.077	8.077	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.155	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K163T	163	K	T	missense	possibly_wt-like	0.794370710212528	0.371597442527625	4	0.185798721263813	0.430211908161859	1.1585295122632	NA	0.935459736317208	0.737703977744167	0.311947577987337	NA	1.1923715488014	NA	NA	0.697657615185924	NA	0.739454718484456	0.655860511887392	0.432502371851979	NA	0.879029110919849	NA	NA	p.Lys163Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.172	-2.992	0.82	11.106	11.106	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K163V	163	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys163Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.172	-3.589	1.417	6.079	6.079	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.39	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K163W	163	K	W	missense	possibly_low	0.630044042083149	0.224350430702122	4	0.112175215351061	0.410184660037045	0.849903424129254	0.573975009379694	NA	0.517305036667647	NA	0.468584836328993	NA	NA	0.960311285956263	0.56767995701805	0.580196547049407	NA	0.547765308540433	NA	0.555163366986694	NA	NA	0.776484020310323	p.Lys163Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.172	-4.321	2.149	11.089	11.089	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K163X	163	K	X	nonsense	low	-0.115200097539586	0.0917927551174123	6	0.0374742353536516	-0.18864824918092	-0.0417519458982509	-0.103008400987541	-0.112223320191706	-0.0606606159375002	-0.0894837120141411	-0.292880073343412	-0.0329444627632123	NA	NA	0.26120218390725	0.258103736739194	0.256490461477635	0.264300631075307	0.256454060933293	0.2707274188184	0.275104312220126	NA	NA	p.Lys163Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K163Y	163	K	Y	missense	possibly_wt-like	0.796877641847002	0.194607893984734	6	0.0794483400300404	0.641161756756631	0.952593526937373	0.993679553726453	0.99516554746319	NA	NA	0.566012965492348	0.633470810271806	0.921591326233761	0.671345647894455	0.699164841332116	0.779882114108255	0.766978092600284	NA	NA	0.591556458703506	0.603562200486995	0.783950271521928	0.631351590063948	p.Lys163Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	92	32.4	0.828	76.5	132.4	51.1	39.4	63.4782608695652	-1.5	0	0	58.48	0	0	0	0	7	15.408925915196	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.172	-3.686	1.514	8.585	8.585	88.09	0.002785651	0	0.079618553	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164A	164	K	A	missense	possibly_wt-like	0.709040426720426	0.181322414822034	7	0.0685334309629707	0.574717370296041	0.84336348314481	0.853286314672944	0.427790385683054	0.70114334117244	0.952179394877771	0.572979428882153	NA	0.825295859303671	0.630608262450945	0.637929257656261	0.713086307559955	0.505427691693388	0.637929257656261	0.713277021878755	0.594158696304332	NA	0.732086169268299	0.610891317379086	p.Lys164Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.595	-3.19	1.595	5.966	5.966	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.445	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164C	164	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.595	-5.476	3.881	1.165	NA	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164D	164	K	D	missense	possibly_wt-like	0.749828403372056	0.156694975964601	2	0.110800080082432	0.532664236926335	0.966992569817778	NA	NA	NA	NA	NA	0.639028323289624	NA	0.860628483454489	0.666359936659312	NA	NA	NA	NA	NA	0.606301346877705	NA	0.726418526440919	p.Lys164Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.595	-3.398	1.803	8.663	8.663	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164E	164	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Glu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.595	-2.53	0.935	8.993	8.993	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.095	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K164F	164	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.595	-3.54	1.945	9.947	9.947	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.38	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164G	164	K	G	missense	possibly_wt-like	0.997350927232424	0.36947129971042	5	0.16523258837754	0.673501004940115	1.32120084952473	NA	0.862599846719273	NA	NA	1.6349543509262	0.731573246916321	0.77251163816773	0.985115553432599	0.705867535579617	NA	0.705867535579617	NA	NA	0.990846501672146	0.651914212329915	0.703656936515732	0.788941915454768	p.Lys164Gly	0	1	NA	NA	NA	NA	NA	NA	NA	0.472	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.595	-2.883	1.288	14.296	14.296	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164H	164	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.595	-4.846	3.251	1.248	NA	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164I	164	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.595	-3.641	2.046	19.607	19.607	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.38	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164L	164	K	L	missense	possibly_low	0.560090020153889	0.277224042164104	8	0.0980135000610916	0.367987090035436	0.752192950272343	0.69996110628669	0.728474214862376	0.695393533146093	0.915704444001161	0.242832400740944	0.195919760085328	0.271999101007523	0.730435601101001	0.637623511906155	0.640137773660523	0.644037876568819	0.635109250151787	0.697280875956384	0.47083629261709	0.387905237376473	0.434084190943543	0.661029404248126	p.Lys164Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.595	-2.91	1.315	12.102	11.834	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164M	164	K	M	missense	possibly_low	0.663079487202268	0.173614370828406	7	0.0656200641769872	0.534466524752166	0.791692449652369	0.971609039650724	0.581898897120659	0.551646898527957	0.530914371484821	NA	0.487902126988041	0.768200038964801	0.749385037678869	0.576469121887842	0.769381481751863	0.576469121887842	0.564608359250983	0.528530596613359	NA	0.531815371979568	0.701334737672253	0.670546721949953	p.Lys164Met	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.595	-3.941	2.346	3.657	3.657	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K164N	164	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Asn	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.595	-3.003	1.408	12.339	12.339	72.21	0.001903541	0	0.054406364	4.068e-06	1	245822	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.625	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	.	D	0.857142857142857
K164P	164	K	P	missense	possibly_low	0.534050314671448	0.299949226960274	7	0.113370151497565	0.311848900814371	0.756251728528525	0.780942796230349	0.699568057527748	0.638842024412012	0.703130783209553	-0.106820006802167	0.502689590463659	NA	0.519998957658985	0.604056369396303	0.678666960193283	0.630712624515435	0.607373423444409	0.604056369396303	0.340227891881149	0.539103708880828	NA	0.555338008965006	p.Lys164Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.595	-4.245	2.65	1.07	NA	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164Q	164	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Gln	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.595	-2.024	0.429	6.529	6.529	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.895	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K164R	164	K	R	missense	wt-like	0.960760460958603	0.229457742175204	8	0.0811255627439205	0.801757279754974	1.11976364216223	0.999127383030702	0.826807106785279	1.02033467131825	1.05076014702369	1.29277435335594	0.513064407492747	1.10323965388424	0.879975964777969	0.76949191301781	0.782474063369972	0.689367684846073	0.794477431482191	0.756509762665648	0.863029328724556	0.544217172858042	0.881784860623664	0.736135761342815	p.Lys164Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.595	-2.384	0.789	12.805	12.805	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.34	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K164S	164	K	S	missense	possibly_wt-like	0.767737603873861	0.249943374158208	4	0.124971687079104	0.522797598111607	1.01267760963611	1.12714835863741	0.586644722013378	0.609492791665435	0.747664543179219	NA	NA	NA	NA	0.608282869221469	0.84338343748514	0.578656867293246	0.592979019976214	0.623586718466724	NA	NA	NA	NA	p.Lys164Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.595	-3.304	1.709	6.057	6.057	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.92	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164T	164	K	T	missense	wt-like	0.861134520495058	0.187003820914825	7	0.0706808006227838	0.722602696875946	0.999666344114171	0.804096646513649	0.59011338270545	0.641305854055797	0.960776072391366	NA	0.972307814664481	0.976308177319204	1.08303369581546	0.717047108051597	0.689683018479268	0.580255861496261	0.608581814759977	0.717047108051597	NA	0.770565706307969	0.813420405996194	0.838121112208244	p.Lys164Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.595	-3.889	2.294	2.866	NA	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K164V	164	K	V	missense	possibly_wt-like	0.756505260856475	0.144911557055868	8	0.0512339723332526	0.656088520298379	0.856922001414572	0.689523106536795	0.70968751745009	0.863782827398139	0.890265981046462	0.740997925902178	0.937819724507839	0.477953435043929	0.742011568966372	0.661881686148632	0.635171618475661	0.635377525233587	0.71769619414852	0.686124798821674	0.656919960681258	0.753567468540071	0.545009834492237	0.666843411616005	p.Lys164Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.595	-3.436	1.841	12.729	7.081	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K164W	164	K	W	missense	possibly_wt-like	0.752204737989001	0.104469037459084	4	0.0522345187295421	0.649826962529315	0.854582513448686	0.652679233077366	NA	NA	NA	NA	0.749971496804049	0.897035174536335	0.709133047538252	0.655656222677949	0.617642168619831	NA	NA	NA	NA	0.660982207243068	0.770724490462934	0.650330238112829	p.Lys164Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.595	-4.115	2.52	11.952	11.952	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.725	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K164X	164	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys164Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K164Y	164	K	Y	missense	possibly_wt-like	0.934348238355848	0.446457323206033	3	0.257762255734683	0.429143500542067	1.43955297616963	1.44936414889235	NA	NA	NA	0.696667041899526	NA	NA	0.657013524275665	0.64036069857441	0.996686144494227	NA	NA	NA	0.64036069857441	NA	NA	0.62415330882422	p.Lys164Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.5	89.6	30.5	0.693	16.1	128.7	-121	77.5	50.4347826086956	-0.8	0	0	52.7	0	0	0	0	5	12.1049377470518	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.595	-3.735	2.14	6.852	6.852	72.21	0.001903541	0	0.054406364	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165A	165	G	A	missense	wt-like	0.924773049711733	0.0798544103097421	4	0.0399272051548711	0.846517165604843	1.00302893381862	NA	NA	NA	NA	0.908651237913824	1.03912180143494	0.853632722983951	0.897686436514217	0.746189514090981	NA	NA	NA	NA	0.719544814643476	0.803496495696048	0.747348216821671	0.74503081136029	p.Gly165Ala	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-0.868	-2.089	1.221	10.638	10.638	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.93	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G165C	165	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-0.868	-3.612	2.744	11.873	11.873	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165D	165	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-0.868	-3.781	2.913	6.451	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G165E	165	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Glu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-0.868	-3.833	2.965	3.832	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	9	2	0	0	2	1	1	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G165F	165	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-0.868	-4.483	3.615	1.301	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165H	165	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-0.868	-3.555	2.687	8.697	8.697	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165I	165	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-0.868	-4.203	3.335	3.871	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165K	165	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-0.868	-3.163	2.295	6.669	6.669	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165L	165	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-0.868	-3.816	2.948	3.064	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G165M	165	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-0.868	-5.014	4.146	0.918	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165N	165	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-0.868	-3.127	2.259	24.52	24.52	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165P	165	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-0.868	-4.119	3.251	1.492	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G165Q	165	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-0.868	-4.287	3.419	2.654	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165R	165	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Arg	1	1	NA	NA	NA	NA	NA	NA	NA	34.296	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-0.868	-4.097	3.229	3.431	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Feb 9, 2015)	criteria provided, single submitter	0	1	0	0	0	13	3	6	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	high	3.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.928571428571429
G165S	165	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-0.868	-2.934	2.066	5.456	5.403	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.535	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G165T	165	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-0.868	-3.765	2.897	3.878	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G165V	165	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Val	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-0.868	-3.16	2.292	6.347	6.347	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.045	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G165W	165	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-0.868	-5.453	4.585	0.28	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G165X	165	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G165Y	165	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly165Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.1	90.2	31.4	0.781	75.1	15	-91.2	-97.3	4.12371134020619	-1.8	0	0	40.8	0	0	0	0	6	9.82324375448354	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-0.868	-4.511	3.643	1.426	NA	36.72	0.00159907	0	0.045704094	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166A	166	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.184	-2.888	1.704	6.756	6.756	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	3.295	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
V166C	166	V	C	missense	possibly_low	0.39013752503536	0.289645435373428	3	0.167226870082395	0.0623788824265075	0.717896167644213	NA	0.070746770746497	NA	NA	0.463887350876913	NA	0.635778453482671	NA	0.553408678475645	NA	0.34083659409421	NA	NA	0.553408678475645	NA	0.630013346655799	NA	p.Val166Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.184	-3.698	2.514	11.873	11.873	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166D	166	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.184	-4.192	3.008	2.334	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166E	166	V	E	missense	low	0.307477147324223	0.194449607529677	7	0.0734950434368053	0.163429509145878	0.451524785502568	NA	0.414668400562287	0.365114232187317	0.534131518061321	-0.0193945893343445	0.163455452714411	0.224832018243429	0.469532998835142	0.473122953738343	NA	0.499378677389937	0.473122953738343	0.52994148120277	0.372884592400897	0.371904466874118	0.408680311804992	0.529991579202823	p.Val166Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.184	-4.029	2.845	2.682	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V166F	166	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.184	-4.146	2.962	3.472	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166G	166	V	G	missense	low	0.486602756245849	0.146922517664494	6	0.0599808666671763	0.369042417816684	0.604163094675013	0.551952783671641	0.33081276612628	0.507903988658412	0.524350903573416	0.698535957414349	NA	NA	0.306060138030995	0.534403359520464	0.569718889164489	0.460722641168283	0.543154541395776	0.525652177645152	0.641058809215823	NA	NA	0.447887652497329	p.Val166Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.184	-3.884	2.7	2.574	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
V166H	166	V	H	missense	low	0.418994101423542	0.0677986268234176	4	0.0338993134117088	0.352552668035958	0.485435534811127	NA	0.47682907272728	0.43769713745887	0.440584268526175	NA	NA	NA	0.320865926981843	0.498818804547843	NA	0.528033701121301	0.508721418352189	0.488916190743498	NA	NA	NA	0.455323831229735	p.Val166His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.184	-5.16	3.976	0.901	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166I	166	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.184	-2.197	1.013	21.022	21.022	77.42	0.001956577	0	0.055922221	4.067e-06	1	245860	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Nov 6, 2014)	criteria provided, single submitter	0	0	1	0	0	2	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.445	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
V166K	166	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.184	-3.993	2.809	2.976	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166L	166	V	L	missense	possibly_wt-like	0.806834077309669	0.157907289406855	8	0.0558286575691868	0.697411919168844	0.916256235450495	0.712919476920628	0.46709574756674	0.841132702072479	0.988069254777759	0.821121899379711	0.897135526415643	0.890758778363926	0.836439232980469	0.710428453400623	0.64630306213083	0.523546802029862	0.706587384410358	0.729016575251582	0.686849295674381	0.733515338386548	0.767344064953326	0.714269522390888	p.Val166Leu	1	0	NA	NA	NA	NA	NA	NA	NA	5.592	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.184	-1.836	0.652	12.975	10.902	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	1.98	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
V166M	166	V	M	missense	possibly_low	0.603457593439205	0.207372027742459	4	0.103686013871229	0.400236740551075	0.806678446327336	NA	0.3247645308774	NA	NA	0.566357342568694	NA	0.754265049528952	0.768443450781776	0.635901934734112	NA	0.457934506507681	NA	NA	0.591685096568487	NA	0.693829444432138	0.680118772899737	p.Val166Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.184	-3.536	2.352	3.738	3.738	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166N	166	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.184	-3.472	2.288	7.309	7.309	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166P	166	V	P	missense	low	0.238399401522367	0.152284347600785	5	0.0681036306289125	0.104918738273279	0.371880064771454	0.203982108004522	0.0596649867264323	NA	0.383371478703619	NA	0.137785069494138	NA	0.407193364683124	0.40416261243037	0.40416261243037	0.335728078162498	NA	0.463825433590088	NA	0.359252236043434	NA	0.498681619078024	p.Val166Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.184	-3.41	2.226	35.969	35.969	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
V166Q	166	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val166Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.184	-4.426	3.242	1.597	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166R	166	V	R	missense	low	0.288093085295693	0.191039791149596	8	0.0675427658991704	0.155711696717099	0.420474473874287	0.254866818028227	0.214408004835269	0.367866008540749	0.468926165087506	0.209635522605766	-0.0733882082030347	0.557871075268838	0.304559296202221	0.452784930239854	0.428372362628627	0.407062005253922	0.474472569226679	0.501345573161186	0.458436002874693	0.255170694612193	0.588052947492588	0.447133857605014	p.Val166Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.184	-4.365	3.181	1.807	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166S	166	V	S	missense	low	0.323659931928687	0.15419362955579	4	0.0770968147778952	0.172552951641257	0.474766912216117	NA	NA	NA	NA	0.404010841915366	0.109605589457797	0.461621394308023	0.319401902033561	0.49281553246838	NA	NA	NA	NA	0.531042537392647	0.345363339915586	0.536213505259498	0.454588527544112	p.Val166Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.184	-3.045	1.861	6.057	6.057	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
V166T	166	V	T	missense	possibly_low	0.608282439273033	0.228039843818965	7	0.0861909593941415	0.439351263067561	0.777213615478505	NA	0.651144883049065	0.92879083202846	0.911156255384878	0.435371830329098	0.464564042922966	0.478469327754711	0.388479903442053	0.545287690897704	NA	0.608390356021433	0.749579530090932	0.695286260829014	0.542757052876746	0.520312667707352	0.545287690897704	0.489282819530595	p.Val166Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.184	-3.618	2.434	3.072	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
V166V	166	V	V	synonymous	wt-like	0.995037086219671	0.151731149588129	4	0.0758655747940643	0.846343291956875	1.14373088048247	NA	0.82874533106143	NA	NA	1.19666392028724	0.9856282789777	0.969110814552315	NA	0.793337476674791	NA	0.690261173617919	NA	NA	0.827128446344403	0.777130999385855	0.809543953963728	NA	p.Val166=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V166W	166	V	W	missense	possibly_low	0.562799010820771	0.200542898523553	6	0.0818712954869086	0.402334220298793	0.723263801342749	NA	0.932911103472641	0.515922815108765	0.504800967337834	0.354318492559295	NA	0.452358370306542	0.616482316139549	0.539155948153761	NA	0.738279841635477	0.547087394573387	0.517078522978548	0.51248056516482	NA	0.531224501734136	0.603796588291386	p.Val166Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.184	-5.607	4.423	0.412	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V166X	166	V	X	nonsense	low	-0.0375819448609029	0.158938876259323	6	0.0648865245211161	-0.164757196004266	0.0895933062824598	NA	-0.0236151889009082	0.0483926707255124	0.100454653542034	-0.348369550675429	-0.0157967570812101	NA	0.0134425032245841	0.299129166374427	NA	0.297337318766922	0.317786084044883	0.339751823882209	0.25	0.28355594804666	NA	0.300921013981933	p.Val166Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V166Y	166	V	Y	missense	possibly_wt-like	0.932613019276589	0.236461987731481	4	0.118230993865741	0.700884529443361	1.16434150910982	0.584972527863472	NA	NA	NA	1.010255850432	NA	1.11457527216013	1.02064842665076	0.782143106433367	0.585428908109712	NA	NA	NA	0.75749798087974	NA	0.88789014973136	0.806788231986995	p.Val166Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	87.2	32.5	0.729	74	150.2	-82.6	108.6	1.21212121212121	-0.9	0	0	31.56	0	0	0	0	5	9.04991921842399	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.184	-4.323	3.139	1.575	NA	77.42	0.001956577	0	0.055922221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.99	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167A	167	T	A	missense	possibly_wt-like	0.751492766621676	0.26427296402913	7	0.0998857915798567	0.555720212557883	0.94726532068547	0.668603157838769	0.791916951248979	0.88738140620619	1.0654511064255	0.219333177372303	NA	0.849393938847542	0.778369628412447	0.685104176327836	0.625218398109393	0.673283910329769	0.729270175232529	0.762952505553118	0.462058443769199	NA	0.745065235691921	0.685104176327836	p.Thr167Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.486	-3.023	1.537	6.756	6.756	77.42	0.002065325	0	0.059030415	4.067e-06	1	245890	NA	NA	NA	0	0	0	0	0	8	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T167C	167	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr167Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.486	-3.938	2.452	10.314	10.314	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167D	167	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr167Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.486	-3.777	2.291	7.007	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167E	167	T	E	missense	possibly_wt-like	0.761016914559756	0.080173144987412	6	0.0327305493822224	0.69686621657639	0.825167612543121	NA	0.83256632154624	0.789064528122809	0.775674499323282	0.608125422835011	0.811121897766471	0.749548817764721	NA	0.686085995073227	NA	0.692022585925832	0.681050420287466	0.63587052790283	0.607287054535047	0.691121569858987	0.691289313164593	NA	p.Thr167Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.486	-2.176	0.69	22.998	22.998	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167F	167	T	F	missense	possibly_wt-like	0.819161630912849	0.117534156975618	4	0.0587670784878091	0.703980273600105	0.934342988225594	0.721710216139698	0.752395510566472	0.817590527296372	0.984950269648856	NA	NA	NA	NA	0.675053129063125	0.650485489434682	0.65506519130355	0.695041066822701	0.727648739516301	NA	NA	NA	NA	p.Thr167Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.486	-4.505	3.019	3.261	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167G	167	T	G	missense	possibly_low	0.581746627865671	0.245110848234171	7	0.0926431925816731	0.400169306992784	0.763323948738559	0.869700790970771	0.549998430626593	0.602587377154169	0.0947450521557935	0.632803072347742	NA	0.55230498678794	0.770086685016689	0.589592242425721	0.720895929951839	0.56176354370486	0.589592242425721	0.337247869394598	0.616505090124813	NA	0.585055089012546	0.680944084101361	p.Thr167Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.486	-3.234	1.748	9.742	9.742	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T167H	167	T	H	missense	wt-like	0.862193746919292	0.0835335490667487	3	0.0482281170400522	0.767668374478608	0.956719119359977	NA	0.765746539126869	0.909274590354705	0.911560111276303	NA	NA	NA	NA	0.695463372452624	NA	0.661219790777971	0.740007741306518	0.695463372452624	NA	NA	NA	NA	p.Thr167His	0	0	NA	NA	NA	NA	NA	NA	NA	-0.409	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.486	-4.921	3.435	1.948	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167I	167	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr167Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.486	-2.95	1.464	19.741	19.741	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
T167K	167	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr167Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.486	-3.099	1.613	7.7	7.7	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167L	167	T	L	missense	possibly_wt-like	0.828675885255028	0.216979793207023	8	0.0767139415785703	0.678319322648921	0.979032447861135	0.506528302489654	0.935368598530819	0.710202879772294	0.819174031595527	0.772833507398816	1.25217486003858	0.91013021489715	0.722994687317388	0.663051987196403	0.54810698763672	0.739412705498739	0.642372530670176	0.654947314822588	0.668811754634549	0.908504529799238	0.777777392680873	0.657292219758257	p.Thr167Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.486	-3.572	2.086	12.185	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
T167M	167	T	M	missense	wt-like	0.825049043659656	0.113794775639456	7	0.0430103824057703	0.740750243183051	0.909347844136261	0.86390567056912	0.921760687918434	0.849389171289509	0.978879806918799	0.639883609470873	0.757273563829166	NA	0.764250795621692	0.710636790068042	0.718138747740769	0.733139687721564	0.710636790068042	0.724986528730197	0.619149938580174	0.664581196660177	NA	0.678013019992057	p.Thr167Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.486	-3.586	2.1	3.939	3.939	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T167N	167	T	N	missense	possibly_low	0.701551586375038	0.127915581403961	3	0.0738520953571242	0.556804139292257	0.846299033457819	0.593352532834839	NA	0.842726480360367	NA	NA	NA	NA	0.668575745929908	0.629960412184269	0.589415917703015	NA	0.707369056896069	NA	NA	NA	NA	0.629960412184269	p.Thr167Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.486	-2.758	1.272	9.195	9.195	77.42	0.002065325	0	0.059030415	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Dec 21, 2012)	no assertion criteria provided	1	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T167P	167	T	P	missense	low	0.405862365914027	0.184766910892777	8	0.0653249678155867	0.277827781704239	0.533896950123815	0.437504115784346	0.39804801323021	0.444000997939122	0.591523489530056	0.598613483147574	0.463671311137572	0.0200305249040921	0.293506991639242	0.513540031307949	0.515266900368955	0.491716958543639	0.511813162246943	0.555110818743267	0.603733985247744	0.519872664590851	0.298375580638792	0.441582859113266	p.Thr167Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.486	-4.171	2.685	2.026	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.905	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T167Q	167	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr167Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.486	-3.14	1.654	5.999	5.999	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167R	167	T	R	missense	possibly_low	0.631500680552357	0.140251702914634	8	0.0495864651019494	0.534312994831884	0.72868836627283	0.416776252860037	0.682995108320568	0.658831211817096	0.834601563827288	0.477751025345171	0.777353072402622	0.613429422357888	0.590267787488187	0.617576737890922	0.505405069903429	0.623072773846351	0.617177169627304	0.661713082859841	0.558587285319357	0.674477838064324	0.617976306154539	0.59063039221197	p.Thr167Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.486	-2.962	1.476	9.647	9.647	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167S	167	T	S	missense	wt-like	1.04546718252923	0.0577333356345593	5	0.0258191326093371	0.994862612502865	1.09607175255559	NA	1.01638986914942	1.07603592834244	1.1051604892161	0.959568679556199	NA	NA	1.07018094638198	0.780367116576296	NA	0.776762147701664	0.821796250144848	0.780367116576296	0.738564405182564	NA	NA	0.831665843778611	p.Thr167Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.486	-2.512	1.026	5.675	5.675	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	4	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	low	1.82	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
T167V	167	T	V	missense	possibly_low	0.599810161710901	0.25156897639283	6	0.102702604546117	0.398516755682053	0.80110356773975	0.333278414580936	0.563925133197001	0.540415799300673	NA	0.552499962292528	1.08244614603118	NA	0.526295514863089	0.563641779094896	0.465678759074697	0.568183519209556	0.559100038980235	NA	0.586508840843616	0.82484988195897	NA	0.55850044258634	p.Thr167Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.486	-2.671	1.185	12.817	7.816	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
T167W	167	T	W	missense	possibly_wt-like	0.715107326333164	0.279011699498153	6	0.113906049339538	0.491855572006426	0.938359080659901	NA	1.04015063472294	0.670862144399304	0.864587138981484	0.883685590603054	NA	0.576224595332157	0.255133853960044	0.648970536597055	NA	0.787715460747848	0.623077770136432	0.674863303057678	0.710219200981871	NA	0.597938032134933	0.422310025274214	p.Thr167Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.486	-5.649	4.163	0.387	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T167X	167	T	X	nonsense	low	0.0581484086263777	0.314305154679676	6	0.128314542081958	-0.193343472547009	0.309640289799764	0.673058516602011	-0.0249281367482243	-0.0526031842161493	-0.043557787257262	-0.234415341321856	NA	NA	0.031336384699747	0.294649139857896	0.627338153192039	0.296732071905642	0.268252418303138	0.276594946016759	0.292566207810149	NA	NA	0.309908181184406	p.Thr167Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T167Y	167	T	Y	missense	wt-like	1.078599511909	0.326655642387586	6	0.133356607575107	0.81722536396135	1.33997365985665	1.09372070612901	1.15606159397136	0.993930734003138	0.852754984213848	1.65945922740996	NA	NA	0.715669825726696	0.804503450375852	0.827479345341045	0.841148462231045	0.781527555410659	0.669674293348537	1	NA	NA	0.65361332225679	p.Thr167Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.8	84.4	31.3	0.658	35.8	96.3	-114.5	-24.6	22.0858895705521	-1.3	0	0	26.52	1	39	0	0	4	10.2143496053346	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.486	-4.547	3.061	1.48	NA	77.42	0.002065325	0	0.059030415	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168A	168	I	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.679	-2.865	1.186	7.943	6.325	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.515	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
I168C	168	I	C	missense	wt-like	0.972883709596766	0.123461312053897	4	0.0617306560269486	0.851893847041916	1.09387357215162	NA	0.996027227608306	0.898272613668149	1.13700317858085	NA	NA	NA	0.860231818529759	0.750993553697766	NA	0.767375312645485	0.734611794750047	0.794331777073367	NA	NA	NA	0.726219302253207	p.Ile168Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.679	-3.991	2.312	11.873	11.873	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.515	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168D	168	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.679	-4.114	2.435	3.562	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168E	168	I	E	missense	wt-like	0.943978461634851	0.0650000006806395	5	0.0290688840118885	0.887004495900777	1.00095242736892	0.935121592084618	0.896544377282052	1.0551142891342	0.935482350727529	NA	NA	NA	0.897629698945858	0.745002315026826	0.75202161096679	0.721515392897579	0.811535180679082	0.705954507433072	NA	NA	NA	0.745002315026826	p.Ile168Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.679	-3.965	2.286	3.753	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.515	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168F	168	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.679	-3.23	1.551	10.808	10.808	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.315	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I168G	168	I	G	missense	possibly_low	0.644540952627463	0.105857632069657	8	0.0374263247384025	0.571186704066493	0.717895201188432	0.778586363797485	0.704239477402669	0.693137493200007	0.766202299860683	0.497098997113823	0.536923421640426	0.574404616507932	0.605734951496674	0.615057612755947	0.677545824973448	0.632866070459838	0.634002769805103	0.631716480229892	0.565814484662682	0.555976629341363	0.596957803565009	0.598398745282002	p.Ile168Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.679	-3.206	1.527	12.652	12.652	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168H	168	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.679	-5.061	3.382	1.404	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168K	168	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.679	-4.012	2.333	3.94	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I168L	168	I	L	missense	possibly_wt-like	0.845697887195565	0.312106001870425	2	0.220692270371599	0.413148985600856	1.27824678879027	NA	NA	NA	NA	1.06639015756716	NA	NA	0.625005616823966	0.693271833760531	NA	NA	NA	NA	0.778466268021993	NA	NA	0.608077399499069	p.Ile168Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.679	-2.581	0.902	10.902	10.902	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.58	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
I168M	168	I	M	missense	possibly_wt-like	0.806506150039507	0.325423055265278	3	0.187883088557919	0.438262063161837	1.17475023691718	NA	0.488323465370788	0.792479037895602	1.13871594685213	NA	NA	NA	NA	0.682725075013199	NA	0.533332422684399	0.682725075013199	0.795082914238468	NA	NA	NA	NA	p.Ile168Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.679	-3.593	1.914	4.019	4.019	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.315	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I168N	168	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile168Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.679	-3.211	1.532	7.781	7.781	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I168P	168	I	P	missense	possibly_wt-like	0.754106523666667	0.226025364433345	6	0.0922744686313847	0.573251888456582	0.934961158876752	0.972408145624976	0.449078487247383	0.65238432433878	0.718263966861469	1.06367838174298	NA	NA	0.668825836184418	0.622050648658916	0.769761677610493	0.515241148245183	0.614015277789169	0.610693050410213	0.777453317171633	NA	NA	0.630086019528663	p.Ile168Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.679	-4.349	2.67	2.117	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168Q	168	I	Q	missense	possibly_low	0.703284658415375	0.0651535591672658	3	0.0376164249238831	0.629557820337409	0.77701149649334	0.714068674080817	NA	NA	NA	0.633411916818544	NA	NA	0.762373384346763	0.646849823155189	0.646849823155189	NA	NA	NA	0.616732516565795	NA	NA	0.677070093827099	p.Ile168Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.679	-2.48	0.801	6.211	6.211	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.34	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I168R	168	I	R	missense	wt-like	0.872300826110182	0.120347070512539	8	0.0425491148276761	0.788906093473878	0.955695558746486	0.929232988290027	0.822582859327857	0.9571754921699	0.837111336080146	0.736925571767828	1.07152707350673	0.707233517119846	0.916617770619119	0.71832016470644	0.749219951552456	0.687420377860423	0.763500856549837	0.662813747349409	0.655398782364612	0.81946816931172	0.668498571819186	0.754539037130245	p.Ile168Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.679	-4.287	2.608	2.879	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168S	168	I	S	missense	wt-like	0.998717814860995	0.14145757484384	5	0.0632617506566183	0.87472706197507	1.12270856774692	1.12070312232611	1.11191982287861	0.811439382090637	0.884971864541184	1.06455488246844	NA	NA	NA	0.77778072334853	0.84031694538972	0.820799848643827	0.692024222510369	0.683803055868958	0.77778072334853	NA	NA	NA	p.Ile168Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.679	-3.333	1.654	15.989	15.989	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
I168T	168	I	T	missense	possibly_wt-like	0.713196685154951	0.127877051264909	6	0.0522055875684588	0.61087561372902	0.815517756580883	NA	0.639918791428077	0.766243270623388	0.946925684544513	0.61515384319371	0.618914123118273	0.692024398021747	NA	0.63510973808437	NA	0.603215316714329	0.669857678353299	0.710972999115051	0.609912435407439	0.596387606932385	0.660307040761301	NA	p.Ile168Thr	1	0	NA	NA	NA	NA	NA	NA	NA	1.9395	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.679	-1.989	0.31	7.506	7.506	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.115	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
I168V	168	I	V	missense	wt-like	1.03023854111383	0.0454727492975983	5	0.0203360317106471	0.990380651372498	1.07009643085516	0.999746373789351	NA	1.10568114870794	0.99279656949153	1.01600493141978	NA	NA	1.03696368216056	0.782768564638329	0.782768564638329	NA	0.836335821469562	0.731089746405074	0.75964548010273	NA	NA	0.814982537365688	p.Ile168Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.679	-2.33	0.651	7.415	7.415	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.13	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I168W	168	I	W	missense	low	0.565789341657896	0.0850297835181925	7	0.0321382373175423	0.502799553988912	0.62877912932688	NA	0.648633411151361	0.586668717230472	0.529927572785848	0.50013854637582	0.619213075860927	0.423771547295693	0.65217252090515	0.581784896469074	NA	0.607232609743556	0.581784896469074	0.528097834523064	0.566949871290954	0.596534952574835	0.515827827736828	0.621721924287615	p.Ile168Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-3.885	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.679	-5.559	3.88	0.744	NA	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.865	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I168X	168	I	X	nonsense	low	0.045268673204215	0.202849990714931	5	0.0907172736947576	-0.132533916013173	0.223071262421603	NA	-0.0557104681023479	-0.052521978461342	-0.0484112636732229	0.407471920822848	NA	NA	-0.0244848445648598	0.281872077248825	NA	0.282541935204452	0.268292245865539	0.27446644645433	0.532335381288972	NA	NA	0.281872077248825	p.Ile168Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I168Y	168	I	Y	missense	low	0.658939301771502	0.0478946057993593	4	0.0239473028996796	0.612003450561258	0.705875152981746	0.654348647432896	0.726007203579503	0.642032443597403	NA	NA	NA	NA	0.613368912476207	0.613687304580102	0.618436436770439	0.642900625886126	0.608938172389765	NA	NA	NA	NA	0.602232887350923	p.Ile168Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	81.4	30.6	0.55	70.6	-140.6	-67.8	117.9	14.6596858638743	-3.4	0	0	20.86	0	0	0	0	6	9.77523492607722	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.679	-3.265	1.586	8.585	8.585	24.57	0.001505212	0	0.043021478	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.315	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169A	169	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.028	-2.329	1.301	8.769	8.769	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169C	169	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.028	-5.185	4.157	1.411	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169D	169	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.028	-3.873	2.845	3.793	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169E	169	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.028	-3.753	2.725	3.996	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169F	169	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.028	-4.531	3.503	3.206	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169G	169	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.028	-3.646	2.618	5.187	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169H	169	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.028	-4.971	3.943	1.495	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169I	169	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.028	-3.048	2.02	7.479	7.479	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169K	169	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.028	-3.736	2.708	4.196	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169L	169	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.028	-2.703	1.675	21.99	21.99	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169M	169	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.028	-4.773	3.745	2.919	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169N	169	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.028	-4.147	3.119	4.257	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169Q	169	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.028	-3.386	2.358	4.778	4.778	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.355	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169R	169	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.028	-3.113	2.085	8.708	8.708	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169S	169	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.028	-3.089	2.061	17.026	17.026	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169T	169	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.028	-3.094	2.066	6.359	5.126	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.045	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P169V	169	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.028	-2.875	1.847	7.148	7.148	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.075	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169W	169	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.028	-5.718	4.69	0.433	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P169X	169	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P169Y	169	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro169Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.2	79.3	33.7	0.867	100.4	57.7	-51.2	-36.3	7.79220779220779	-3.3	1	0	23.59	0	0	0	0	8	13.074914831845	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.028	-4.539	3.511	1.393	NA	77.42	0.00115551	0	0.033026413	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170A	170	S	A	missense	low	0.433309609592398	0.225455933011988	4	0.112727966505994	0.212366855190213	0.654252363994584	NA	0.181074499261864	0.333427357575476	0.517447673910536	NA	NA	NA	0.701288907621716	0.490103401849233	NA	0.391695820172781	0.457582048061272	0.522624755637194	NA	NA	NA	0.646390534081182	p.Ser170Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-0.971	-2.639	1.668	7.188	7.188	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.78	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S170C	170	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-0.971	-2.396	1.425	14.031	14.031	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.025	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S170D	170	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-0.971	-3.66	2.689	1.654	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170E	170	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-0.971	-3.656	2.685	0.999	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170F	170	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-0.971	-3.344	2.373	9.278	9.278	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170G	170	S	G	missense	low	0.202378295749784	0.131512813578306	8	0.0464968011470713	0.111246240105204	0.293510351394364	0.284314517113041	0.261926172276935	0.272236871267099	0.3332122081658	-0.0792455127717193	0.22034804467618	0.107915860545975	0.21831820472496	0.415695230179916	0.442382886387625	0.428967080734729	0.427571023379866	0.441828008189931	0.350528008479017	0.399945271714449	0.345710041747271	0.403819436979965	p.Ser170Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-0.971	-2.799	1.828	11.892	11.892	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
S170H	170	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-0.971	-4.796	3.825	0.636	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170I	170	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-0.971	-3.96	2.989	2.827	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Aug 25, 2015)	criteria provided, single submitter	1	0	0	0	0	5	0	0	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S170K	170	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-0.971	-3.649	2.678	1.119	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170L	170	S	L	missense	low	0.362059972390649	0.140047811746866	8	0.049514378688273	0.265013573444757	0.459106371336542	0.589837872521612	0.229749357591016	0.346107525425984	0.478316277374796	0.454300680418291	0.343016527289011	0.160152314024035	0.29499922448045	0.462103142161202	0.587743724854214	0.414134110686121	0.463801067606372	0.50546362137688	0.549827694418417	0.460405216716031	0.373844250458465	0.442332330158303	p.Ser170Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-0.971	-2.99	2.019	9.225	9.225	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170M	170	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-0.971	-4.73	3.759	1.224	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170N	170	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-0.971	-3.051	2.08	6.287	6.287	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	8	5	2	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	3.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S170P	170	S	P	missense	low	0.172296763091925	0.171782754965224	3	0.0991788198213073	-0.0220901517870246	0.366683677970875	NA	-0.000728974663897205	0.174810313764376	0.342808950175296	NA	NA	NA	NA	0.379787928355853	NA	0.307887478365291	0.379787928355853	0.446036674188758	NA	NA	NA	NA	p.Ser170Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-0.971	-4.042	3.071	0.721	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170Q	170	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-0.971	-4.091	3.12	0.68	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170R	170	S	R	missense	low	0.286042073759003	0.126701067433551	7	0.0478885021822288	0.192182334208266	0.379901813309739	0.137315161043155	0.275263756132422	0.388556151417996	0.401233743532271	0.0855810909846398	NA	0.357951302519241	0.356393310683293	0.471658957360134	0.372444044482094	0.435115482426455	0.484620100746883	0.471658957360134	0.412096979980237	NA	0.480377478781948	0.47316739066286	p.Ser170Arg	1	0	NA	NA	NA	NA	NA	NA	NA	12.13	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-0.971	-4.063	3.092	0.88	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	Bannayan-Riley-Ruvalcaba syndrome	Pathogenic(Last reviewed: Aug 1, 1997)	no assertion criteria provided	1	0	0	0	0	1	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S170T	170	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-0.971	-3.381	2.41	1.243	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
S170V	170	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-0.971	-3.715	2.744	2.354	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170W	170	S	W	missense	low	0.345807378227982	0.188446276519674	4	0.094223138259837	0.161133420728363	0.5304813357276	NA	0.493118128414369	0.333432578706291	0.472734039174284	NA	NA	NA	0.0839447666169829	0.4803000654942	NA	0.535542681655425	0.457584608777736	0.503015522210663	NA	NA	NA	0.336330638782444	p.Ser170Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-0.971	-5.495	4.524	0.431	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S170X	170	S	X	nonsense	low	0.146852788746021	0.182877535109413	4	0.0914387675547065	-0.032363902451933	0.326069479943976	NA	0.0240069203207063	-0.0429298475962015	0.316503665521224	0.289830416738356	NA	NA	NA	0.376895380360414	NA	0.31929030965899	0.272996730067385	0.434500451061837	0.488391829415239	NA	NA	NA	p.Ser170Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S170Y	170	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser170Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	78.6	33.4	0.909	109.7	44.8	-62.1	-38.7	0	-1.9	1	0	22.33	1	104	0	0	9	12.468629349692	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-0.971	-4.357	3.386	2.152	NA	24.57	0.001039325	0	0.029705635	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171A	171	Q	A	missense	possibly_low	0.671196888152502	0.170031178781585	8	0.0601150997648006	0.553373457686461	0.789020318618544	0.381497708411794	0.770510541985141	0.729977488253371	0.738119723406058	0.616829559195229	0.708372076980342	0.496539389749796	0.927728617238286	0.629939906168734	0.488620366835411	0.663415915919567	0.652071036091427	0.619400823044665	0.610538378722355	0.640478989292804	0.555020106897336	0.760119438255964	p.Gln171Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-0.822	-3.307	2.485	4.259	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171C	171	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-0.822	-5.292	4.47	0.788	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171D	171	Q	D	missense	possibly_wt-like	0.8835544822191	0.248750860663488	6	0.101552113617283	0.684515996975305	1.08259296746289	1.11398696473154	NA	NA	0.715820547017634	0.484684888600127	0.977043393272695	0.880664489318864	1.12912661037374	0.76740354562149	0.837121555309267	NA	NA	0.609621484871885	0.56117734553663	0.772899743675228	0.761907347567752	0.86127118898502	p.Gln171Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-0.822	-3.435	2.613	7.007	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171E	171	Q	E	missense	possibly_low	0.591357297164909	0.352758701453377	7	0.133330256694245	0.330034795994709	0.85267979833511	1.19145173185898	0.266650588882431	0.537397535237775	0.263354182557977	0.667988707770562	0.319740571726846	NA	0.892917762119791	0.557619723938611	0.873977472547428	0.431144957280015	0.557619723938611	0.411191663393973	0.629648255944101	0.44893313388617	NA	0.742635753911388	p.Gln171Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-0.822	-2.596	1.774	22.998	22.998	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q171F	171	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-0.822	-3.256	2.434	28.024	28.024	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
Q171G	171	Q	G	missense	low	0.32012382786307	0.206404693699781	8	0.0729750792919237	0.177095300681945	0.463152355044196	0.486430111751763	0.408987872826406	0.386983263405278	0.105294981709432	-0.0779436932997778	0.31586032322028	0.538460515044908	0.396917248246275	0.488684566756266	0.538544740412071	0.496760049704473	0.483848673948068	0.341874557259967	0.35101428729652	0.447020665366935	0.577598548003721	0.493520459564464	p.Gln171Gly	0	0	NA	NA	NA	NA	NA	NA	NA	4.813	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-0.822	-3.547	2.725	2.763	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171H	171	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-0.822	-4.435	3.613	1.948	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q171I	171	Q	I	missense	possibly_low	0.640456632806981	0.17800726486591	7	0.0672804220568574	0.508589428710886	0.772323836903076	0.386155432938873	0.612224803518254	0.784410203618426	0.823669433849169	0.410230884636993	NA	0.724956601135051	0.7415490699521	0.656918780409266	0.490836402796711	0.590448854365503	0.678767695373787	0.656918780409266	0.533365958638591	NA	0.678044107771378	0.666611122384738	p.Gln171Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-0.822	-4.169	3.347	4.67	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171K	171	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-0.822	-3.257	2.435	5.89	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q171L	171	Q	L	missense	possibly_low	0.705147830247657	0.250871714270083	8	0.0886965451841348	0.531305796133623	0.878989864361691	0.963318324146152	0.644196658991448	0.634381913617386	0.672706314421512	0.967310783853991	0.180269560742209	0.842753501062498	0.736245585146059	0.634567399556088	0.765436953990243	0.605187341666418	0.605185951122899	0.590713671718917	0.741456374003172	0.380191681527452	0.741488739775012	0.663947457445758	p.Gln171Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-0.822	-3.558	2.736	8.303	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Q171M	171	Q	M	missense	wt-like	0.981280228495736	0.186608841678321	7	0.070531512503809	0.843041004213134	1.11951945277834	0.912133041688108	1.2122942142127	1.00108169926768	0.644611038408732	1.14769260175149	NA	0.907413173901279	1.04373583024017	0.785034763932724	0.74108419848551	0.867070753792104	0.785034763932724	0.578392445122889	0.808835806402846	NA	0.776314012352291	0.818383835580157	p.Gln171Met	0	0	NA	NA	NA	NA	NA	NA	NA	2.643	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-0.822	-4.501	3.679	1.825	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171N	171	Q	N	missense	possibly_wt-like	0.984087915491235	0.251197647128493	3	0.145029029189436	0.699836241567132	1.26833958941534	NA	1.10608485824357	0.695190744267517	1.15098814396261	NA	NA	NA	NA	0.80046490519526	NA	0.818110028146958	0.635009791846955	0.80046490519526	NA	NA	NA	NA	p.Gln171Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-0.822	-2.944	2.122	7.781	7.781	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171P	171	Q	P	missense	low	0.294674166808425	0.121467691803161	8	0.0429453142845463	0.210502897505961	0.378845436110889	0.377152409274858	0.242220839004957	0.40115854149099	0.438937559544991	0.100053319303614	0.349496138801171	0.150851015717785	0.297523511329034	0.453599494297653	0.486552975538635	0.419883253728416	0.490800973989486	0.488194023981881	0.417502904707335	0.463598840272078	0.368834632645436	0.443600148323228	p.Gln171Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-0.822	-3.899	3.077	2.026	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	1	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q171R	171	Q	R	missense	low	0.553256113251847	0.151530398697521	7	0.0572731072885866	0.441002885683519	0.665509340820175	0.615966610582839	0.613179612053729	0.539515008869493	0.718297393037236	0.321374625984612	NA	0.687414593096348	0.377044949138671	0.590889005031351	0.600175164891179	0.590889005031351	0.558658244095216	0.610707709511113	0.500174784811093	NA	0.657824230285977	0.483539635950231	p.Gln171Arg	1	0	NA	NA	NA	NA	NA	NA	NA	10.112	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-0.822	-3.519	2.697	3.839	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q171S	171	Q	S	missense	possibly_wt-like	0.845323267299845	0.184311080006826	5	0.082426420780333	0.683770451195848	1.00687608340384	0.915990599198949	0.896143158946107	0.729487693863939	0.602839443191516	NA	NA	NA	1.08215544129871	0.721330437997036	0.742919533769319	0.721330437997036	0.651830815227092	0.560073447661722	NA	NA	NA	0.837680010583686	p.Gln171Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-0.822	-3.374	2.552	4.211	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171T	171	Q	T	missense	wt-like	0.83803390807008	0.095534028674838	8	0.033776379755024	0.771833420222085	0.904234395918075	0.80264022414977	0.909130627685908	0.701832510413163	0.769776236481093	0.898909499729344	0.949362375805185	0.740748245521626	0.931871544774549	0.702447996920895	0.688990086916992	0.727317442512713	0.638267262407339	0.633283835642947	0.715905906924797	0.759256526134536	0.686549383100827	0.762200215561202	p.Gln171Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-0.822	-3.627	2.805	2.921	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171V	171	Q	V	missense	wt-like	0.988921535674236	0.329958775347137	7	0.124712694638851	0.744489145767147	1.23335392558132	0.722921159423248	0.966576802508826	0.887806297039832	0.863622279937255	1.65945922740996	1.12817631034661	NA	0.693888673053922	0.729478563988113	0.651061627814666	0.753799162312291	0.729478563988113	0.674440162636785	1	0.847389031058503	NA	0.642673780648418	p.Gln171Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-0.822	-3.734	2.912	3.95	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171W	171	Q	W	missense	wt-like	0.873131929393266	0.0779541637264907	2	0.055121917792728	0.765094955760741	0.98116890302579	NA	NA	0.928253847185994	0.818010011600538	NA	NA	NA	NA	0.701876498306249	NA	NA	0.749316164552708	0.65443683205979	NA	NA	NA	NA	p.Gln171Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-0.822	-5.285	4.463	1.302	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q171X	171	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	2	0	6	0	2	3	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q171Y	171	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln171Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	82.4	33.5	0.967	114.5	47.6	-70.1	-46.8	1.86915887850467	-2.2	1	0	21.2	0	0	0	0	8	10.0616816616309	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-0.822	-4.092	3.27	6.5	NA	77.42	0.000745031	0	0.021294224	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R172A	172	R	A	missense	possibly_low	0.700664530513636	0.11636102008485	8	0.0411398331838907	0.620031939143224	0.781297121884047	0.816164957953391	0.848568981411721	0.730905573461881	0.648831793012064	0.666062064111811	0.56950962890497	0.530972660543261	0.794300584709987	0.640727399712205	0.695424837684582	0.699399542806111	0.652526217767197	0.580243463559235	0.628928581657213	0.572037480972199	0.573565639042226	0.69310546817388	p.Arg172Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.898	-2.745	0.847	9.272	9.272	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R172C	172	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.898	-3.84	1.942	15.23	15.23	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R172D	172	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.898	-4.08	2.182	6.451	NA	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R172E	172	R	E	missense	low	0.488613758167435	0.0231677199957257	3	0.0133758893760421	0.4623974967292	0.514830019605669	NA	0.477018017214703	0.473533473945213	0.51528978334239	NA	NA	NA	NA	0.526297437822973	NA	0.52812080135015	0.526297437822973	0.521678409402778	NA	NA	NA	NA	p.Arg172Glu	0	0	NA	NA	NA	NA	NA	NA	NA	1.319	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.898	-3.283	1.385	7.15	7.15	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R172F	172	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.898	-4.498	2.6	3.682	NA	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R172G	172	R	G	missense	low	0.339474150036757	0.114229386542094	8	0.0403861869173468	0.260318678205855	0.41862962186766	0.430986946666004	0.215827678950123	0.233658795056956	0.376945147794108	0.210265532224168	0.414929119242063	0.51855183983512	0.314628140525517	0.459839245782175	0.512166184333011	0.407716451128381	0.408650310910462	0.461007156265419	0.458671335298931	0.495848969355619	0.566875867074573	0.452190915102279	p.Arg172Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.898	-3.095	1.197	13.79	13.79	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.535	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R172H	172	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.898	-3.751	1.853	9.663	9.663	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.68	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R172I	172	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.898	-2.176	0.278	11.521	11.521	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.035	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R172K	172	R	K	missense	possibly_wt-like	0.731476483154933	0.188955792937547	7	0.0714185766996807	0.591498644996447	0.871454321313418	NA	0.793323610350016	0.748765213846702	0.86621481101687	0.352292768294503	0.776786655638313	0.651987556880252	0.930964766057875	0.673932356501895	NA	0.673932356501895	0.661285522370346	0.675577121137376	0.511723880523592	0.674198666710047	0.638743462650378	0.761744787712655	p.Arg172Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.898	-2.438	0.54	10.313	10.313	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.565	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
R172L	172	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.898	-2.776	0.878	11.648	11.648	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R172M	172	R	M	missense	possibly_low	0.576814052514828	0.310381543560511	6	0.126712734550114	0.328461656414021	0.825166448615635	NA	0.641772799039707	0.790026929410853	0.992008515618881	0.238254057604101	NA	0.601958716669056	0.19686329674637	0.607934121439964	NA	0.60406998302116	0.681522432368942	0.73074414416467	0.469126108267653	NA	0.611798259858769	0.393043751135343	p.Arg172Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.898	-3.993	2.095	3.014	3.014	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R172N	172	R	N	missense	low	0.307821107459341	0.253482864587256	8	0.0896197262321202	0.132169671740046	0.483472543178636	0.499986555993362	0.368309565521728	0.319285981079461	0.507027248763044	-0.268089875655525	0.421302395053346	0.195968531766946	0.418778457152361	0.488499108791861	0.544994578261453	0.478008034634988	0.450646375137998	0.518054862128733	0.279987495409017	0.498990182948733	0.393134628693041	0.504500209260466	p.Arg172Asn	0	0	NA	NA	NA	NA	NA	NA	NA	0.503	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.898	-2.834	0.936	24.52	24.52	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R172P	172	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.898	-4.367	2.469	2.117	NA	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R172Q	172	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.898	-3.19	1.292	10.67	10.67	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R172R	172	R	R	synonymous	wt-like	1.15625910618414	0.1202844651367	4	0.0601422325683499	1.03838249640034	1.27413571596794	NA	1.19881558487994	0.987156778303584	1.26948941518118	1.16957464637186	NA	NA	NA	0.834721699068667	NA	0.860857332509092	0.778205252158066	0.852433820323101	0.817009577814234	NA	NA	NA	p.Arg172=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R172S	172	R	S	missense	low	0.300064131984065	0.292248797293931	7	0.110459662656781	0.0835671714323305	0.5165610925358	NA	0.488360522508531	0.37321499194867	0.763807617946836	-0.116460563150332	0.31667067877354	0.259742657162635	0.0151130186985759	0.447420067488313	NA	0.533349505401243	0.477095991310081	0.630666288785875	0.336626779405802	0.447420067488313	0.427482951268382	0.301760027132876	p.Arg172Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.898	-2.567	0.669	15.989	15.989	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
R172T	172	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.898	-3.432	1.534	5.972	5.248	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.68	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R172V	172	R	V	missense	possibly_low	0.60308302795346	0.215247907917939	6	0.0878745904334218	0.430851995547746	0.775314060359175	NA	0.611278497093516	0.725680562451208	0.462293918220294	0.249370132282253	0.83730394540935	0.732571112264142	NA	0.619988110640452	NA	0.590012623029619	0.649963598251286	0.498436991075908	0.473278382654597	0.70402598611001	0.68214523315558	NA	p.Arg172Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.898	-2.647	0.749	13.762	13.762	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.295	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R172W	172	R	W	missense	low	0.364609250290373	0.0603304335811316	3	0.0348317920683932	0.296340192319335	0.432878308261412	0.434199996803147	NA	NA	NA	0.327055758846982	NA	NA	0.33257199522099	0.502296902838926	0.513694878142182	NA	NA	NA	0.502296902838926	NA	NA	0.461203181257554	p.Arg172Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.898	-5.762	3.864	0.771	NA	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.23	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R172X	172	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg172Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R172Y	172	R	Y	missense	low	0.313911114572995	0.155872435000082	4	0.0779362175000409	0.161158935181635	0.466663293964355	0.32848505316246	NA	NA	NA	NA	0.376869817006895	0.0938897322445931	0.456399855878031	0.470244384474728	0.463398190265379	NA	NA	NA	NA	0.477090578684076	0.338155661716344	0.523395483670763	p.Arg172Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.1	82.9	36.4	0.877	105.7	62.3	-58	-38.2	23.0188679245283	-4.9	1	0	25.87	1	6	0	0	7	12.7544775612331	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.898	-3.83	1.932	8.9	8.9	77.42	0.002861876	0	0.081797187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173A	173	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.046	-3.359	2.313	5.656	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173C	173	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.046	-3.315	2.269	31.06	31.06	77.42	0.001387849	0	0.039667029	0	NA	NA	PTEN hamartoma tumor syndrome|not provided|Neoplasm of brain|Hereditary cancer-predisposing syndrome	Pathogenic/Likely pathogenic(Last reviewed: Mar 1, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	57	8	2	0	8	1	4	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R173D	173	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.046	-3.988	2.942	2.885	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173E	173	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.046	-3.583	2.537	3.765	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173F	173	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.046	-4.432	3.386	3.981	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173G	173	R	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.046	-3.715	2.669	3.325	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R173H	173	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.046	-3.509	2.463	25.564	25.564	77.42	0.001387849	0	0.039667029	8.132e-06	2	245938	PTEN hamartoma tumor syndrome|not provided|Neoplasm of brain	Pathogenic/Likely pathogenic(Last reviewed: Mar 1, 2017)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	35	9	2	0	8	0	2	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R173I	173	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.046	-3.291	2.245	8.367	6.67	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173K	173	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.046	-2.158	1.112	8.594	8.594	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173L	173	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.046	-2.515	1.469	27.302	27.302	77.42	0.001387849	0	0.039667029	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Mar 2, 2015)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	3.485	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
R173M	173	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.046	-4.679	3.633	3.623	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173N	173	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.046	-3.83	2.784	3.939	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173P	173	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.046	-4.169	3.123	2.055	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Jun 17, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R173Q	173	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.046	-3.875	2.829	2.889	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173S	173	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.046	-3.652	2.606	7.151	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Dec 14, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R173T	173	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.046	-3.097	2.051	19.038	19.038	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173V	173	R	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.046	-3.755	2.709	6.968	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173W	173	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.046	-5.565	4.519	0.538	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R173X	173	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R173Y	173	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg173Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	80	38.2	0.9	98.3	54.1	-55.6	-43.9	11.6981132075472	-6	1	0	23.11	2	151	0	0	8	15.3724974503169	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.046	-4.376	3.33	4.191	NA	77.42	0.001387849	0	0.039667029	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174A	174	Y	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-0.997	-3.529	2.532	3.306	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174C	174	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-0.997	-3.611	2.614	12.832	12.832	72.7	0.001217726	0	0.034804649	0	NA	NA	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Mar 21, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174D	174	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-0.997	-4.165	3.168	2.235	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174E	174	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-0.997	-3.967	2.97	3.794	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174F	174	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-0.997	-2.124	1.127	11.669	11.669	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174G	174	Y	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-0.997	-3.789	2.792	2.426	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174H	174	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-0.997	-4.296	3.299	1.748	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174I	174	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-0.997	-3.871	2.874	1.945	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174K	174	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-0.997	-3.944	2.947	8.781	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174L	174	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-0.997	-3.422	2.425	3.457	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174M	174	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-0.997	-4.731	3.734	1.131	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174N	174	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-0.997	-4.186	3.189	2.787	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Aug 26, 2014)	criteria provided, single submitter	0	1	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174P	174	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-0.997	-4.405	3.408	1.349	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174Q	174	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-0.997	-4.246	3.249	3.502	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.63	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174R	174	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-0.997	-3.354	2.357	25.013	25.013	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y174S	174	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-0.997	-2.961	1.964	4.639	4.639	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y174T	174	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-0.997	-3.866	2.869	2.508	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174V	174	Y	V	missense	low	0.241865657492121	0.121784462465563	3	0.0703122921876069	0.104056097133955	0.379675217850288	NA	0.285435111399999	0.335872693253209	0.104289167823155	NA	NA	NA	NA	0.439804306025384	NA	0.439804306025384	0.458781368965651	0.341433456029973	NA	NA	NA	NA	p.Tyr174Val	0	0	NA	NA	NA	NA	NA	NA	NA	6.169	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-0.997	-3.656	2.659	2.227	NA	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174W	174	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-0.997	-2.749	1.752	13.676	13.676	72.7	0.001217726	0	0.034804649	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.59	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y174X	174	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr174Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.1	81.7	38.4	0.774	102	57.8	-67.7	-20	0	-3.9	1	0	20.62	0	0	0	0	7	14.8424667040219	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	2	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V175A	175	V	A	missense	low	0.328144086517522	0.131402976314856	8	0.046457967810165	0.237088142814677	0.419200030220366	0.469590945054103	0.227278278848081	0.390056653013542	0.504728822328704	0.157173472777775	0.363907670141221	0.170152419802548	0.342264430174197	0.468386539185249	0.530533060300162	0.412994984972793	0.485356025449156	0.517046883673604	0.438839442749425	0.47070189049043	0.379230241358955	0.466071187880068	p.Val175Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.071	-3.266	2.195	3.875	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V175C	175	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.071	-3.655	2.584	14.631	14.631	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V175D	175	V	D	missense	low	0.0828844304447938	0.12170773569191	5	0.0544293540789378	-0.0237951432517026	0.18956400414129	NA	0.182955057748408	NA	NA	-0.0970355414444835	0.012501110045816	0.140294459386518	0.17570706648771	0.363148941153764	NA	0.392562725986108	NA	NA	0.343882759815286	0.297503193938354	0.363148941153764	0.382418075595213	p.Val175Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.071	-4.21	3.139	1.342	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175E	175	V	E	missense	low	0.231259123045918	0.198157393150015	7	0.0748964546748277	0.0844647693135196	0.378053476778317	NA	0.458247825144899	0.245978802497796	0.356855516260827	-0.101741518944553	0.041745599570659	0.376809901067814	0.240917735723987	0.415170007512561	NA	0.519468058700025	0.414692688895805	0.452196817394227	0.342124899203079	0.311917004157658	0.490534595359341	0.415170007512561	p.Val175Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.071	-4.048	2.977	1.962	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V175F	175	V	F	missense	low	0.13289905741255	0.162373753955282	6	0.0662888074684439	0.00297538219629029	0.26282273262881	0.167451310166893	-0.0364177899580937	NA	NA	0.0446125563695588	0.0607873906030696	0.129800313940383	0.431160563353489	0.372139490178244	0.386782116604019	0.291435535141689	NA	NA	0.396793682559324	0.321302182925906	0.357496863752468	0.510719098041124	p.Val175Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.071	-3.347	2.276	9.469	9.469	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175G	175	V	G	missense	low	0.196914791201618	0.119198022967041	8	0.0421428651720122	0.114316293259146	0.279513289144089	0.119594371411732	0.253066807535316	0.274816734550654	0.327841189169564	0.0113293704603392	0.31514823107683	0.0610734521909181	0.212448173217587	0.412877143874552	0.364012908879812	0.424883062688044	0.428836323679772	0.439472539531282	0.384361153598503	0.446669694596676	0.320481030100267	0.40087122506106	p.Val175Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.071	-3.947	2.876	2.117	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V175H	175	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.071	-5.185	4.114	1.106	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175I	175	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.071	-1.789	0.718	10.578	10.578	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V175K	175	V	K	missense	low	0.244807404852041	0.167502590035086	8	0.0592211086400598	0.12873616479299	0.360878644911092	0.330417504752758	0.146243454045595	0.251744819621393	0.466026467209937	0.00429741301127114	0.0380408714025503	0.398548982464464	0.323139726308363	0.436993244357674	0.464317605355876	0.37563929451921	0.417520646191938	0.500073906187945	0.381734451489059	0.310091044819785	0.502243120967034	0.456465842523409	p.Val175Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.071	-4.04	2.969	2.626	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175L	175	V	L	missense	possibly_wt-like	0.815481633040013	0.281544867256421	8	0.0995411424226407	0.620384578911665	1.01057868716836	1.00957939259903	0.842240589404048	0.963675528467126	1.05018407717674	0.434091325811729	0.97904666320435	0.312071512258298	0.932963975398779	0.75950300653301	0.787446884097479	0.69648226059462	0.766688815357077	0.756257126346428	0.542278736001069	0.773887100715206	0.455666926880309	0.762748886719591	p.Val175Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.071	-2.554	1.483	29.072	29.072	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.09	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
V175M	175	V	M	missense	low	0.155669913527239	0.253567478654875	6	0.103518489678085	-0.047222597975788	0.358562425030267	NA	0.367523258753879	0.237513441097462	0.383861768967993	-0.297928331978357	0.191336712802374	0.0517126315200855	NA	0.39809360504313	NA	0.477645560448206	0.410540831552457	0.464040451141168	0.268841703254637	0.385646378533802	0.315439353934945	NA	p.Val175Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.071	-3.507	2.436	11.696	11.696	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.425	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V175N	175	V	N	missense	possibly_low	0.524524946081103	0.377113794485014	5	0.168650415944275	0.193976204852624	0.855073687309583	0.360056755642342	0.404154560003109	0.555903760712288	NA	1.14835385387748	NA	NA	0.154155800170299	0.494531973835456	0.478419264965728	0.494531973835456	0.566696147791108	NA	0.809082809085498	NA	NA	0.371593993962145	p.Val175Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.071	-4.388	3.317	1.53	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175P	175	V	P	missense	low	0.35512257073739	0.355807226944787	8	0.12579685148392	0.108565272460373	0.601679869014407	0.271487830483116	0.137948109904636	0.784495915918106	1.03279328427157	0.0868461356690933	0.060535267798467	0.2277703595574	0.239103662296733	0.413414207341021	0.436280250074336	0.371815280477212	0.678809733182217	0.74863036731506	0.412569522023511	0.321177918480996	0.410262883022748	0.41425889265853	p.Val175Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.071	-3.374	2.303	9.821	9.821	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175Q	175	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.071	-4.472	3.401	2.138	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175R	175	V	R	missense	low	0.130575941862543	0.178007261353564	8	0.0629350708017755	0.00722546972658424	0.253926413998501	0.340932751492563	0.362567241772549	0.125187852466366	0.217005450495178	-0.166787753218104	-0.022139525176698	0.0638985363812726	0.123942980687214	0.355935067053222	0.46932051284469	0.475360920027393	0.355450470025132	0.390865355514863	0.31782767015764	0.280429770873496	0.322002601779545	0.356419664081312	p.Val175Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.071	-4.419	3.348	2.321	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175S	175	V	S	missense	low	0.286139734980775	0.196979262299222	6	0.0804164470904904	0.128526394918743	0.443753075042806	NA	0.210047033445801	0.301820296508654	0.388396797872359	0.444442943274331	-0.0712494290466516	NA	0.443380767830154	0.454054791095239	NA	0.405051670836603	0.442080287133883	0.466029295056594	0.546145456700408	0.25622484044828	NA	0.516856671995252	p.Val175Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.071	-3.867	2.796	2.473	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175T	175	V	T	missense	low	0.437432117553288	0.159570771050153	7	0.0603120823876472	0.319222608240887	0.555641626865689	0.551304786439555	0.45412798531137	0.402715527329823	0.636785336959524	0.124684280986436	0.428607722307417	NA	0.463799183538892	0.517568881871855	0.569410587297177	0.517568881871855	0.491564601527962	0.574960471691316	0.426703500626541	0.502590779243657	NA	0.527111781611282	p.Val175Thr	0	0	NA	NA	NA	NA	NA	NA	NA	1.673	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.071	-2.891	1.82	6.102	6.102	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.225	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175V	175	V	V	synonymous	wt-like	1.01879507807705	0.248304107699102	5	0.111044972781524	0.80115093076103	1.23643922539307	0.631178945633869	1.20568207581198	0.974244198787731	1.02023116585365	NA	1.26263900429801	NA	NA	0.771872245739422	0.607412836705483	0.864022669268745	0.771872245739422	0.743121230922064	NA	0.91366202072876	NA	NA	p.Val175=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V175W	175	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.071	-5.56	4.489	0.574	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V175X	175	V	X	nonsense	low	-0.0212468856156157	0.165694395418985	5	0.0741007863295162	-0.166481758047565	0.123987986816334	NA	0.141227155039272	-0.0531054525164797	0.0840087631303818	-0.286677198829381	NA	0.00831230509812851	NA	0.292064224874889	NA	0.373326865099395	0.268006079578488	0.332539453295665	0.273044427089374	NA	0.292064224874889	NA	p.Val175Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V175Y	175	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val175Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	84.8	40.1	0.862	109.5	45.2	-75.2	-32.6	0	-4	1	0	25.45	0	0	0	0	8	15.4050938932549	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.071	-4.245	3.174	2.196	NA	77.42	0.002121629	0	0.060639679	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.775	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y176A	176	Y	A	missense	possibly_wt-like	0.849288027191105	0.240525209147587	7	0.090909983920902	0.671107732871022	1.02746832151119	NA	1.11250869395144	0.776843730781995	0.462605879664526	1.15606202426393	0.940097615104249	0.761944364791052	0.734953881780545	0.69796547289421	NA	0.821071308297964	0.67505670013997	0.498573802248073	0.811962102306581	0.754690178605812	0.69796547289421	0.663298701940252	p.Tyr176Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.528	-2.99	0.462	8.05	8.05	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.505	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176C	176	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Cys	1	0	NA	NA	NA	NA	NA	NA	39	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.528	-4.291	1.763	43.173	43.173	49.88	0.003047043	0	0.087089552	1.805e-05	5	276944	PTEN hamartoma tumor syndrome|Tumor susceptibility linked to germline BAP1 mutations|not specified	Uncertain significance(Last reviewed: Jun 17, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	2	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.545	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Y176D	176	Y	D	missense	wt-like	1.04792363691965	0.181651735020138	2	0.128447173647042	0.796171802655487	1.29967547118382	NA	NA	0.919476463272609	1.17637081056669	NA	NA	NA	NA	0.778303893876971	NA	NA	0.74501127499953	0.811596512754412	NA	NA	NA	NA	p.Tyr176Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.528	-3.005	0.477	16.046	16.046	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.155	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Y176E	176	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.528	-2.42	-0.108	21.598	21.598	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y176F	176	Y	F	missense	possibly_low	0.552119636520119	0.511522584351077	4	0.255761292175538	0.0508367152166379	1.0534025578236	1.2288266062115	NA	0.545015872907728	0.444032666689014	NA	-0.00939659972776606	NA	NA	0.525892323740121	0.891759560159683	NA	0.561356156407737	0.490428491072504	NA	0.28671041081777	NA	NA	p.Tyr176Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.528	-3.334	0.806	12.817	12.817	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.74	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
Y176G	176	Y	G	missense	possibly_wt-like	0.798135403140596	0.265414191591835	7	0.100317135054178	0.601517431402167	0.994753374879026	NA	0.971665469962222	0.971244832111172	0.889478591096687	0.722158529296255	0.233794728786811	0.830301236328771	0.968304434402258	0.734782032262932	NA	0.756144952368278	0.770401198967459	0.68577948774567	0.649882733399401	0.406572775083415	0.734782032262932	0.780498563586361	p.Tyr176Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.528	-2.176	-0.352	25.43	25.43	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.59	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176H	176	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.528	-2.757	0.229	30.308	30.308	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	-0.45	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
Y176I	176	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.528	-3.586	1.058	22.571	22.571	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176K	176	Y	K	missense	wt-like	1.09012867280588	0.0523127855328186	5	0.02339498890875	1.04427533712602	1.13598200848575	NA	1.06598418737785	1.15982111388464	1.1079944678065	1.01856781973726	NA	1.09827577522317	NA	0.799624293754466	NA	0.799624293754466	0.862888900701193	0.781609962254862	0.760602815837277	NA	0.879111348373713	NA	p.Tyr176Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.528	-2.679	0.151	14.232	14.232	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.16	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176L	176	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.528	-3.103	0.575	13.931	13.511	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176M	176	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.528	-4.164	1.636	5.627	5.627	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176N	176	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.528	-2.615	0.087	15.011	15.011	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Y176P	176	Y	P	missense	low	0.422252771260659	0.0974365887247709	4	0.0487182943623855	0.326766668922163	0.517738873599155	NA	0.528601009337218	0.299103999327515	0.400116423057299	NA	NA	NA	0.461189653320604	0.498485052436684	NA	0.551899692599622	0.440748072492961	0.471168954743813	NA	NA	NA	0.525801150129554	p.Tyr176Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.528	-4.406	1.878	1.903	NA	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y176Q	176	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.528	-2.796	0.268	10.298	10.298	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176R	176	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr176Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.528	-2.764	0.236	13.403	13.403	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176S	176	Y	S	missense	possibly_wt-like	0.780189065898375	0.247046410401284	8	0.0873440960312715	0.608997783414875	0.951380348381875	1.01572476048335	0.824758949020055	0.655569908334713	0.400085764184865	0.5367682384534	0.710183992112099	1.02856969323553	1.06985122136299	0.664897775681856	0.79037070583659	0.688423518585897	0.615577655303949	0.471155509248055	0.580632446896022	0.641372032777815	0.841568113171048	0.831500240028492	p.Tyr176Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.528	-3.456	0.928	4.529	4.529	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Y176T	176	Y	T	missense	possibly_wt-like	0.805768353692137	0.198179488396089	7	0.0749048058928661	0.658957631873156	0.952579075511118	NA	0.78832178990499	0.975086426924484	1.12162348341498	0.584138061751737	0.565538326056018	0.80855982951255	0.797110558280203	0.694516771939646	NA	0.671626601455171	0.77228531860294	0.787586988055087	0.598326867785651	0.570080134254297	0.723072254199621	0.694516771939646	p.Tyr176Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.528	-3.28	0.752	6.224	6.224	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176V	176	Y	V	missense	possibly_wt-like	0.770552910495213	0.251717133555784	8	0.0889954460390672	0.596125041470563	0.944980779519862	0.919128597717979	0.736635171210592	0.792430660414631	1.03685340068353	0.938869002059744	0.204394813721473	0.772124248607123	0.763987389546631	0.693074819608225	0.744412519780889	0.647799940100051	0.682701348158535	0.750410937625002	0.730832292618092	0.392082359859875	0.703448291057915	0.677880724802665	p.Tyr176Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.528	-3.284	0.756	22.514	22.514	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y176W	176	Y	W	missense	possibly_low	0.619185157508754	0.154582843618525	3	0.089248446375253	0.444261416937104	0.794108898080404	NA	0.742945739467117	0.445912118533194	0.668697614525951	NA	NA	NA	NA	0.588955650201484	NA	0.650709005862228	0.512750476048125	0.588955650201484	NA	NA	NA	NA	p.Tyr176Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.528	-5.601	3.073	0.595	NA	49.88	0.003047043	0	0.087089552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.74	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y176X	176	Y	X	nonsense	low	-0.0392083603039453	0.0117177519166241	3	0.00676524722336017	-0.0524680012082408	-0.0259487193996497	NA	-0.0262761135159793	-0.0491202716689018	NA	NA	NA	NA	-0.0422286957269547	0.272960262479576	NA	0.296110677301562	0.269960621338032	NA	NA	NA	NA	0.272960262479576	p.Tyr176Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	82.5	42.8	0.838	107.7	58.6	-74.2	-35.3	36.4705882352941	-4.2	1	0	28.79	0	0	0	0	9	18.5865160226439	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Y177A	177	Y	A	missense	low	0.142409058817566	0.204248763272552	5	0.0913428237995379	-0.0366195860757169	0.321437703710848	NA	0.0913812076120405	0.210486103541604	0.459316895882657	0.0168894222194337	-0.0660283351679072	NA	NA	0.386438043254053	NA	0.350348722220754	0.397285207297833	0.497131413341531	0.386438043254053	0.258798175032953	NA	NA	p.Tyr177Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-0.902	-3.493	2.591	7.943	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y177C	177	Y	C	missense	low	0.223818970817883	0.132767850638046	6	0.0542022480515438	0.117584516755751	0.330053424880015	0.280121685958534	0.0503435638980615	0.367201030989004	NA	0.0792054649523473	NA	0.226489866145849	0.339552212963502	0.425051739129591	0.440388035776767	0.331431059114055	0.474146429349028	NA	0.409715442482414	NA	0.409573217731649	0.464708982055928	p.Tyr177Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-0.902	-5.094	4.192	1.325	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	6	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y177D	177	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-0.902	-4.108	3.206	3.562	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	high	3.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y177E	177	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-0.902	-3.887	2.985	4.037	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177F	177	Y	F	missense	low	0.2612120754323	0.107394441342135	5	0.0480282542493253	0.16707842686329	0.355345724001311	NA	0.351186302654895	0.327466305702616	NA	0.337643335023001	0.125617351040873	0.164147082740118	NA	0.454658435492123	NA	0.47011449863034	0.454658435492123	NA	0.506251763043483	0.353255099918411	0.375995806495064	NA	p.Tyr177Phe	1	0	NA	NA	NA	NA	NA	NA	NA	1.307	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-0.902	-2.518	1.616	10.808	10.808	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.32	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y177G	177	Y	G	missense	low	0.253730240283929	0.0954664807919823	8	0.033752497972013	0.187576559870523	0.319883920697336	0.275957468056277	0.273159990305123	0.218057349199144	0.300977847949421	0.218466261824084	0.148502451479797	0.444494382871912	0.150226170585677	0.430918630811376	0.438406798679459	0.434145681785521	0.400998543373515	0.427691579837231	0.461734618018586	0.364534540932287	0.526989010060088	0.369620345138674	p.Tyr177Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-0.902	-3.792	2.89	4.871	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y177H	177	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-0.902	-3.003	2.101	27.409	27.409	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y177I	177	Y	I	missense	low	0.248968374874816	0.0981008524336955	2	0.0693677779960469	0.113010028314994	0.384926721434638	NA	NA	0.318336152870863	NA	NA	NA	NA	0.179600596878769	0.417277061611578	NA	NA	0.450180529554296	NA	NA	NA	NA	0.384373593668859	p.Tyr177Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-0.902	-3.751	2.849	4.159	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177K	177	Y	K	missense	low	0.430002373916974	0.124166951062881	7	0.0469306962236442	0.338019899549241	0.521984848284706	0.597639979610335	0.409648259208048	0.342471110861141	0.617924085384458	0.36231595090552	0.350789085312448	NA	0.329228146136867	0.497064476712398	0.591455784204657	0.497064476712398	0.462017579128975	0.566688840743986	0.515467918381955	0.464236098297096	NA	0.459523739552267	p.Tyr177Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-0.902	-3.899	2.997	3.94	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y177L	177	Y	L	missense	low	0.378771930794409	0.304960178922118	5	0.136382338100071	0.111467459990905	0.646076401597913	0.902417814243477	0.316063540812863	0.303179595518266	0.269483531440256	NA	NA	NA	0.102715171957181	0.442746958680197	0.736461921391975	0.453923496521755	0.442746958680197	0.41387969879289	NA	NA	NA	0.345758038393015	p.Tyr177Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-0.902	-2.827	1.925	8.945	8.945	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y177M	177	Y	M	missense	possibly_low	0.46861471596934	0.499983341649183	5	0.223599347909015	0.0303680471010296	0.90686138483765	NA	0.0164969506739584	0.290273569785129	0.534765506858809	NA	1.29854590930824	NA	0.202991643220559	0.436417166580423	NA	0.315828340041316	0.436417166580423	0.530219517967016	NA	0.931359553590138	NA	0.396121701244416	p.Tyr177Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-0.902	-3.174	2.272	6.712	6.712	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.32	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177N	177	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-0.902	-4.079	3.177	4.224	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y177P	177	Y	P	missense	low	0.35046936831219	0.11398654698797	5	0.0509763335171148	0.250557590554743	0.450381146069637	NA	0.545979329639456	0.257567277215706	0.293003545564551	0.347842830765128	NA	NA	0.30795385837611	0.448838769861099	NA	0.559910805789487	0.420376284855908	0.424194437236299	0.510061660525822	NA	NA	0.448838769861099	p.Tyr177Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-0.902	-4.322	3.42	2.117	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177Q	177	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-0.902	-4.152	3.25	3.098	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177R	177	Y	R	missense	low	0.142070445368264	0.166356436560425	7	0.062876822876254	0.0188341370685025	0.265306753668026	0.132122689480301	0.248903801928947	0.415485453144613	NA	-0.05264322865072	-0.0389966811405442	0.0774868527564958	0.212134230058759	0.369973588437641	0.369973588437641	0.422963987165057	0.497827643087658	NA	0.360464967899319	0.272121339068123	0.329321179199714	0.400713547719541	p.Tyr177Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-0.902	-4.144	3.242	3.664	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177S	177	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-0.902	-3.104	2.202	15.989	15.989	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	high	3.665	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
Y177T	177	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr177Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-0.902	-3.836	2.934	5.972	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	high	3.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y177V	177	Y	V	missense	low	0.399493087990914	0.197897945098787	8	0.0699674894811177	0.262359328519238	0.536626847462589	0.640144804826985	0.160601081367617	0.282138276270857	0.397175507534975	0.582105979474561	0.168683088165854	0.632494738176137	0.332601228110324	0.46554853756418	0.611678581980969	0.382257919082127	0.432427191844533	0.469879211708939	0.597567808186289	0.374481025621324	0.628244759287574	0.461217863419421	p.Tyr177Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-0.902	-3.531	2.629	3.834	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	3.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177W	177	Y	W	missense	low	0.0389781935308637	0.00663397014381014	2	0.00469092527487725	0.0297841489379356	0.0481722381237917	NA	NA	NA	NA	0.0436691188057409	NA	0.0342872682559864	NA	0.351247720676732	NA	NA	NA	NA	0.396441272941239	NA	0.306054168412225	NA	p.Tyr177Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-0.902	-4.607	3.705	0.502	NA	77.42	0.001087267	0	0.031075888	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	high	4.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y177X	177	Y	X	nonsense	possibly_low	0.512495835649881	0.325416084057237	2	0.230103919744044	0.0615004402500605	0.963491231049701	NA	0.282391915905837	NA	NA	NA	NA	NA	0.742599755393925	0.552770135612295	NA	0.438401444118214	NA	NA	NA	NA	NA	0.667138827106377	p.Tyr177Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	80.8	43	0.949	110.2	43	-57	-48.5	10.1960784313725	-4.2	1	0	27.47	1	99	0	0	7	19.4763384099784	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	1	1	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Y178A	178	Y	A	missense	possibly_low	0.60429705275161	0.26893699998901	6	0.109793070487993	0.389106588843075	0.819487516660144	0.319408113882122	0.464154097216821	0.670264102908185	1.07775964382427	0.660614467263644	NA	NA	0.433581891414614	0.572487604969881	0.45907959569268	0.522190750725227	0.622784459214534	0.768350433599346	0.626893698164796	NA	NA	0.511935205355101	p.Tyr178Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.495	-3.621	2.126	5.381	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178C	178	Y	C	missense	low	0.414460947104116	0.108514110755518	3	0.0626506510555714	0.29166792742721	0.537253966781023	NA	NA	NA	NA	0.395636680118668	NA	0.316590521611671	0.53115563958201	0.527914471186966	NA	NA	NA	NA	0.527914471186966	NA	0.458100835460436	0.560941430783028	p.Tyr178Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.495	-3.823	2.328	17.029	17.029	77.42	0.002658958	0	0.07599745	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Apr 14, 2016)	criteria provided, single submitter	0	0	1	0	0	1	3	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y178D	178	Y	D	missense	low	0.197772483522374	0.234786545799759	6	0.095851205946667	0.00990757199217537	0.385637395052573	0.190019353977	0.328619040057164	0.371079492240368	0.448996155315245	-0.163640780180999	0.0115616397254659	NA	NA	0.428615416147663	0.397519461925463	0.459711370369863	0.476048630219829	0.492605236659299	0.319003183629501	0.297040154674403	NA	NA	p.Tyr178Asp	1	0	NA	NA	NA	NA	NA	NA	NA	13.009	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.495	-4.315	2.82	1.397	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y178E	178	Y	E	missense	low	0.360829121536172	0.12495614078964	6	0.0510131308603321	0.260845222311293	0.460813020761052	0.345959978440473	0.118445498779161	0.455495104674521	0.437590601124227	0.386974108271918	NA	NA	0.420509437926735	0.496486452140777	0.471712349381483	0.362824904968712	0.517450475197659	0.487603313290513	0.524678672917724	NA	NA	0.50536959099104	p.Tyr178Glu	0	0	NA	NA	NA	NA	NA	NA	NA	9.115	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.495	-4.158	2.663	1.804	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178F	178	Y	F	missense	possibly_wt-like	0.812759222290283	0.105129098486724	2	0.0743374984399911	0.667060402647098	0.958458041933468	NA	NA	NA	NA	0.738421723850292	NA	0.887096720730274	NA	0.710664678335375	NA	NA	NA	NA	0.655957651763285	NA	0.765371704907465	NA	p.Tyr178Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.495	-1.434	-0.061	15.686	15.686	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.02	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Y178G	178	Y	G	missense	low	0.229646095544272	0.083032540762202	8	0.0293564363160507	0.172108537650369	0.287183653438175	0.285725994205428	0.284489493005055	0.280251075606791	0.28146904242432	0.220979719590117	0.0778131704492215	0.124681677004064	0.281758592069176	0.433591928944333	0.443054434045091	0.439368391859655	0.431501609631922	0.419135963107099	0.462673489572327	0.329693724837746	0.354739999717974	0.435682248256744	p.Tyr178Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.495	-3.949	2.454	1.934	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178H	178	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr178His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.495	-4.623	3.128	0.695	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y178I	178	Y	I	missense	possibly_wt-like	0.748181605138326	0.167033978640738	4	0.0835169893203692	0.584491313973186	0.911871896303466	0.921077092770576	0.858498744962063	0.634266742292494	NA	NA	NA	NA	0.57888384052817	0.654553230876146	0.745339567974029	0.703976996689277	0.605129465063016	NA	NA	NA	NA	0.584912826970702	p.Tyr178Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.495	-3.742	2.247	12.712	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178K	178	Y	K	missense	low	0.221655230377362	0.124051011877663	2	0.0877173117117485	0.0497324586016616	0.393578002153063	0.309372542089111	NA	NA	NA	NA	NA	NA	0.133937918665614	0.407872254270345	0.454304906280236	NA	NA	NA	NA	NA	NA	0.361439602260455	p.Tyr178Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.495	-4.144	2.649	2.056	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178L	178	Y	L	missense	low	0.53247597992298	0.15276693874329	3	0.0882000332067134	0.359607091402585	0.705344868443375	NA	0.40135667056627	0.495842031042401	0.700229238160269	NA	NA	NA	NA	0.537238724582426	NA	0.493242193892318	0.537238724582426	0.60278389234306	NA	NA	NA	NA	p.Tyr178Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.495	-2.589	1.094	10.157	10.157	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.21	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y178M	178	Y	M	missense	low	0.412543123405995	0.181305338225153	8	0.0641011170621631	0.286907242595369	0.53817900421662	0.443690243256021	0.58451788838996	0.632779186022864	0.398795367079762	0.0375274087608932	0.342578927663965	0.381721749941019	0.478734216133474	0.505695099635982	0.51821011456265	0.577676432786522	0.604399889427714	0.470589603608844	0.394147111913212	0.460189535811699	0.493180084709314	0.534612872712629	p.Tyr178Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.495	-3.433	1.938	3.657	3.657	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.615	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178N	178	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr178Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.495	-4.422	2.927	1.276	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y178P	178	Y	P	missense	low	0.344945373513998	0.36972043188659	8	0.130715912265114	0.0887468932680777	0.601143853759918	0.691228395024652	0.20202305900062	0.254672965648943	0.379666235748682	-0.070567353079289	1.06411877739025	0.0315026979666378	0.206918210411482	0.410154758139275	0.635982954696065	0.401352753657326	0.418956762621225	0.462200493581656	0.353769629398272	0.815816822476597	0.304554417252349	0.398093811986602	p.Tyr178Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.495	-3.577	2.082	12.153	12.153	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178Q	178	Y	Q	missense	low	0.244801209589768	0.0725047991001069	2	0.0512686351122539	0.144316531233224	0.345285887946311	NA	NA	NA	NA	NA	0.193532574477514	NA	0.296069844702021	0.414799352934398	NA	NA	NA	NA	NA	0.38672865878446	NA	0.442870047084335	p.Tyr178Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.495	-4.469	2.974	1.238	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178R	178	Y	R	missense	low	0.135134469528582	0.112252987122621	8	0.0396874242014259	0.0573485474546244	0.212920391602541	0.0903371256274485	0.0904865455249662	0.249063115928793	0.341889040598273	0.0561708186909046	0.0256737535671085	0.0453745669091841	0.182080789381981	0.367856131931822	0.350092998329147	0.349936298055381	0.41620539801265	0.445633246425983	0.401111130757907	0.303995630184887	0.312025714211815	0.385619265534498	p.Tyr178Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.495	-4.414	2.919	1.679	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178S	178	Y	S	missense	low	0.501677702807801	0.274679518821957	7	0.103819099577969	0.298196006727604	0.705159398887997	0.249242258950236	0.858274765360761	0.903343750319283	0.535395604913853	0.357058599144707	NA	0.289428362239853	0.319000578725912	0.513504098626184	0.425696329490381	0.703873745862554	0.737098946207431	0.530495848440167	0.513504098626184	NA	0.443471475886199	0.45438696369263	p.Tyr178Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.495	-3.984	2.489	2.504	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y178T	178	Y	T	missense	low	0.355641853274204	0.176457844262124	8	0.0623872691356538	0.233365052674515	0.477918653873893	0.600650735689007	0.392007005635854	0.507082488677256	0.50531867148512	0.189472095089315	0.0907023771243965	0.248258496104423	0.311642956388261	0.469918177836474	0.592888231250903	0.488932155710134	0.54275163470721	0.517305562930229	0.450904199962814	0.336046462803493	0.421297657999565	0.450691612169657	p.Tyr178Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.495	-3.957	2.462	3.865	NA	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.31	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y178V	178	Y	V	missense	possibly_low	0.607194215680149	0.283245029325834	7	0.107056558241622	0.397367217217755	0.817021214142543	0.409802395699227	0.408494541244346	0.402662544068893	0.54440540164924	1.20145309645362	NA	0.670152588753149	0.613388941892572	0.534447108684429	0.502087072420434	0.496532632147696	0.491538615757177	0.534447108684429	0.828917384805683	NA	0.648527028798723	0.602242947086375	p.Tyr178Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.495	-2.843	1.348	20.844	20.844	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y178W	178	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr178Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.495	-2.817	1.322	15.401	15.401	77.42	0.002658958	0	0.07599745	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.74	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y178X	178	Y	X	nonsense	low	-0.00486532199318196	0.266678777380702	3	0.153967063907908	-0.306635222058059	0.296904578071695	-0.0193558623400079	NA	NA	NA	-0.264003400559154	NA	NA	0.268763296919616	0.297903650370684	0.297903650370684	NA	NA	NA	0.281513948439141	NA	NA	0.429155386518183	p.Tyr178Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.3	84.1	43.8	0.934	110.6	53.5	-65.8	-46.9	2.74509803921569	-4.5	1	0	29.88	0	0	0	0	7	19.6191696526637	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	1	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S179A	179	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.218	-2.161	-0.057	22.425	22.425	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.36	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S179C	179	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.218	-5.396	3.178	1.659	NA	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.095	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S179D	179	S	D	missense	possibly_wt-like	0.901134463628862	0.298177783342967	3	0.172153023479428	0.563720737779505	1.23854818947822	0.778927361262864	NA	NA	NA	0.683474569256664	NA	NA	1.24100146036706	0.677708063560466	0.677708063560466	NA	NA	NA	0.635432811002452	NA	NA	0.917460115017486	p.Ser179Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.218	-2.549	0.331	14.668	14.668	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.225	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S179E	179	S	E	missense	possibly_wt-like	1.01340710636709	0.301765427880869	3	0.174224351019142	0.671933653139704	1.35488055959447	NA	NA	NA	NA	1.1876778481225	0.664958408446657	NA	1.1875850625321	0.823771808469147	NA	NA	NA	NA	0.823771808469147	0.619081577700554	NA	0.890631832994776	p.Ser179Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.218	-2.004	-0.214	16.217	16.217	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.29	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S179F	179	S	F	missense	possibly_wt-like	0.75502232829177	0.278076010540437	6	0.113524055922145	0.532519267305455	0.977525389278084	0.74196822660225	0.405352285473952	0.562224125608455	0.70504550744567	1.20131343757182	0.914230387048474	NA	NA	0.632509924896307	0.660123775131576	0.495084105120323	0.569795986317288	0.604896074661038	0.828865216930368	0.741940928331545	NA	NA	p.Ser179Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.218	-3.844	1.626	13.677	13.677	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S179G	179	S	G	missense	possibly_wt-like	0.761071244882836	0.29925390354917	8	0.105802232248082	0.553702680192653	0.968439809573018	0.992609171486535	1.05486066915007	0.904875600015696	0.690419432352029	0.433092048613565	0.206145454551203	0.85173245621385	0.954835126679737	0.742087495678766	0.779372851372298	0.794496539055363	0.737850245662964	0.598481786886919	0.541905468167277	0.392945202914819	0.746324745694569	0.773733629954054	p.Ser179Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.218	-2.479	0.261	26.062	26.062	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.22	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
S179H	179	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.218	-2.937	0.719	10.981	10.981	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.94	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S179I	179	S	I	missense	low	0.32430751961164	0.206758219802613	3	0.119371913860206	0.0903428676800184	0.558272171543262	NA	0.0855834610154932	0.446330252103044	0.441008845716384	NA	NA	NA	NA	0.489102389724625	NA	0.347676058613264	0.512955550687042	0.489102389724625	NA	NA	NA	NA	p.Ser179Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.218	-3.216	0.998	7.614	7.614	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	low	1.195	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
S179K	179	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.218	-3.142	0.924	7.769	7.769	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.29	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S179L	179	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.218	-3.863	1.645	4.699	NA	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S179M	179	S	M	missense	low	0.371086450113485	0.207948327360769	4	0.103974163680385	0.167300833977258	0.574872066249711	0.666495282318261	0.356544838028971	0.193192953102263	0.268112727004444	NA	NA	NA	NA	0.442931611825437	0.624215520432056	0.472584693256002	0.388803739083332	0.413278530394871	NA	NA	NA	NA	p.Ser179Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.218	-5.077	2.859	1.399	NA	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S179N	179	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.218	-2.812	0.594	27.978	27.978	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.775	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
S179P	179	S	P	missense	possibly_low	0.243352399411489	0.562326300979488	4	0.281163150489744	-0.307717249328225	0.794422048151202	NA	0.0463280041247436	NA	NA	-0.291676332108307	NA	0.187711226204275	1.03104669942524	0.359133626056291	NA	0.329579953638655	NA	NA	0.271177061704379	NA	0.388687298473928	0.812010744283778	p.Ser179Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.218	-4.283	2.065	2.25	NA	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.095	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S179Q	179	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.218	-3.179	0.961	5.892	5.892	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.195	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S179R	179	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.218	-3.643	1.425	7.769	7.769	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00093504207689346	0.000866690123354582	0.000866690123354582	0.00139122286577568	0.000791779931602594	0.000543045589468079	0.000165477839033609	neutral	neutral	low	1.545	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S179S	179	S	S	synonymous	low	0.225184012352542	0.31885905235583	2	0.225467398163524	-0.216723967735916	0.667091992441001	NA	NA	NA	NA	-0.000283385810981498	NA	0.450651410516066	NA	0.455164247158643	NA	NA	NA	NA	0.380023349848228	NA	0.530305144469059	NA	p.Ser179=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S179T	179	S	T	missense	low	0.409867250771997	0.110326624756985	2	0.0780127045110878	0.256965159593699	0.562769341950294	0.331854546260909	NA	NA	NA	NA	NA	NA	0.487879955283084	0.502103809196058	0.46500131596208	NA	NA	NA	NA	NA	NA	0.539206302430035	p.Ser179Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.218	-3.143	0.925	6.224	6.224	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.095	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S179V	179	S	V	missense	low	0.0811436369850443	0.0313414478526321	3	0.0180949933545098	0.0456781017097136	0.116609172260375	0.0804859688590214	NA	NA	NA	0.112808743289282	NA	0.0501361988068292	NA	0.345406049255124	0.345406049255124	NA	NA	NA	0.422267538073321	NA	0.314590297691253	NA	p.Ser179Val	0	0	NA	NA	NA	NA	NA	NA	NA	1.502	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.218	-3.325	1.107	7.349	7.349	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S179W	179	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.218	-3.909	1.691	27.23	27.23	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.995	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S179X	179	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S179Y	179	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser179Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.6	85.2	46.2	0.863	106.9	56.7	-53.4	-35.8	4.1958041958042	-4.6	1	0	37.74	1	4	0	0	7	21.4222962788773	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.218	-3.592	1.374	8.348	8.348	77.42	0.003196426	0	0.09135917	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.895	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y180A	180	Y	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-3	-2.797	-0.203	12.003	12.003	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.69	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y180C	180	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-3	-3.792	0.792	39.335	39.335	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.46	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Y180D	180	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-3	-2.867	-0.133	21.756	21.756	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.515	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
Y180E	180	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-3	-2.814	-0.186	15.111	15.111	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.1	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180F	180	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-3	-3.391	0.391	32.233	32.233	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
Y180G	180	Y	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-3	-2.982	-0.018	13.158	13.158	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.72	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y180H	180	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-3	-3.095	0.095	31.977	31.977	90.32	0.002979925	0	0.085171217	4.065e-06	1	246014	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Y180I	180	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-3	-3.182	0.182	7.95	7.95	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180K	180	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-3	-2.283	-0.717	11.138	11.138	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180L	180	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-3	-2.87	-0.13	15.654	15.654	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y180M	180	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-3	-3.923	0.923	5.868	5.868	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180N	180	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-3	-2.975	-0.025	15.797	15.797	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
Y180P	180	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-3	-4.405	1.405	2.117	NA	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y180Q	180	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-3	-2.574	-0.426	10.67	10.67	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.395	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y180R	180	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-3	-2.61	-0.39	13.488	13.488	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-1.22	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180S	180	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-3	-2.883	-0.117	15.989	15.989	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.515	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Y180T	180	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-3	-2.858	-0.142	11.106	11.106	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.93	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180V	180	Y	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-3	-3.559	0.559	7.349	7.349	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.11	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y180W	180	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-3	-4.048	1.048	13.184	13.184	90.32	0.002979925	0	0.085171217	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y180X	180	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr180Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.3	81.9	48	0.903	106.1	46.8	-63.3	-46.6	39.2156862745098	-4.2	1	0	32.11	0	0	0	0	8	23.8458587150893	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	2	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L181A	181	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.719	-2.481	0.762	9.775	9.775	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.275	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L181C	181	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.719	-3.816	2.097	11.273	11.273	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181D	181	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.719	-3.731	2.012	9.943	9.943	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181E	181	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.719	-4.184	2.465	3.996	NA	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181F	181	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.719	-2.869	1.15	14.156	14.156	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.325	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L181G	181	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.719	-3.519	1.8	15.941	15.941	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181H	181	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.719	-4.096	2.377	7.906	7.906	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181I	181	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.719	-2.072	0.353	10.511	10.511	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.555	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L181K	181	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.719	-4.165	2.446	4.196	NA	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.875	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181M	181	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.719	-2.785	1.066	8.28	8.28	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.53	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L181N	181	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.719	-4.443	2.724	4.257	NA	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181P	181	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.719	-4.488	2.769	2.254	NA	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L181Q	181	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.719	-3.855	2.136	5.627	5.627	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L181R	181	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.719	-4.449	2.73	3.066	NA	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	1	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L181S	181	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.719	-3.201	1.482	17.026	17.026	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.53	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181T	181	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.719	-3.043	1.324	7.506	7.506	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181V	181	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.719	-2.234	0.515	8.15	8.15	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.225	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L181W	181	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.719	-3.87	2.151	15.894	15.894	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.425	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L181X	181	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L181Y	181	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu181Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	82.6	48.5	0.906	112.1	52.7	-63.2	-42.1	7.32984293193717	-5.1	1	0	33.12	0	0	0	0	9	24.7824538304826	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.719	-2.824	1.105	11.814	11.814	77.42	0.002687925	0	0.076825376	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L182A	182	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.631	-3.164	1.533	6.325	6.325	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182C	182	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.631	-3.737	2.106	14.631	14.631	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182D	182	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.631	-4.311	2.68	2.043	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182E	182	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.631	-4.064	2.433	2.609	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182F	182	L	F	missense	low	0.361746139567816	0.10701283193464	6	0.0436878056950136	0.276119613842006	0.447372665293626	NA	0.266099693926628	0.451915369376215	0.520256715860605	0.368357808382381	NA	0.314074937330662	0.249772312530405	0.486220371796764	NA	0.430891003976709	0.515694785206098	0.52385666531371	0.517724780698654	NA	0.45674595838743	0.419617201508837	p.Leu182Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.631	-3.24	1.609	11.095	11.095	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L182G	182	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.631	-4.029	2.398	2.355	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182H	182	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.631	-4.002	2.371	10.893	10.893	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182I	182	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.631	-2.358	0.727	13.88	13.88	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	1.99	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
L182K	182	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.631	-2.531	0.9	10.175	10.175	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182M	182	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.631	-2.918	1.287	4.944	4.944	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L182N	182	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.631	-4.328	2.697	2.41	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182P	182	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.631	-4.423	2.792	1.456	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182Q	182	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.631	-4.401	2.77	1.956	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182R	182	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.631	-2.817	1.186	10.671	10.671	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182S	182	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.631	-3.131	1.5	6.276	6.276	24.57	0.003142802	0	0.089826506	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Mar 1, 2015)	no assertion criteria provided	1	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L182T	182	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.631	-3.086	1.455	13.486	13.486	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.685	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L182V	182	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.631	-2.084	0.453	13.829	13.829	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.77	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
L182W	182	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.631	-5.539	3.908	0.805	NA	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L182X	182	L	X	nonsense	possibly_low	0.33115054948314	0.586940618056146	2	0.415029691181324	-0.482292697747036	1.14459379671332	0.746180240664465	NA	NA	NA	NA	-0.0838791416981843	NA	NA	0.456063876259742	0.662127752519484	NA	NA	NA	NA	0.25	NA	NA	p.Leu182Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L182Y	182	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu182Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.3	86.1	49.8	0.978	109.4	43.6	-59.1	-62.8	27.2251308900524	-4.1	1	0	34.87	0	0	0	0	7	25.4105808249241	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.631	-2.981	1.35	9.294	9.294	24.57	0.003142802	0	0.089826506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K183A	183	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.072	-2.651	0.579	12.291	12.291	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.99	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K183C	183	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.072	-3.71	1.638	17.869	17.869	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.54	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K183D	183	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.072	-3.225	1.153	12.108	12.108	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K183E	183	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.072	-2.722	0.65	12.384	12.384	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
K183F	183	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.072	-3.72	1.648	9.565	9.565	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K183G	183	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.072	-3.418	1.346	11.133	11.133	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.54	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K183H	183	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.072	-3.61	1.538	11.948	11.948	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.735	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K183I	183	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.072	-3.757	1.685	8.367	7.883	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.195	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K183L	183	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.072	-3.176	1.104	27.302	27.302	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.54	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K183M	183	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.072	-4.114	2.042	4.662	4.662	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K183N	183	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.072	-2.689	0.617	13.832	13.832	58.31	0.003550619	0	0.101482606	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: May 6, 2015)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.215	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
K183P	183	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.072	-3.369	1.297	19.396	19.396	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.54	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K183Q	183	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.072	-2.481	0.409	10.67	10.67	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	0.835	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K183R	183	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.072	-2.246	0.174	29.623	29.623	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.265	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K183S	183	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.072	-2.614	0.542	8.786	8.786	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.95	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K183T	183	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.072	-2.644	0.572	12.631	12.631	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.735	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
K183V	183	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.072	-3.385	1.313	13.428	13.428	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.54	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K183W	183	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.072	-5.795	3.723	0.538	NA	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K183X	183	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K183Y	183	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys183Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.7	85.3	52.5	0.837	120.2	43.1	-55.4	-35.9	51.7391304347826	-2.8	1	0	52.31	1	4	0	0	6	27.7488821010865	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.072	-4.601	2.529	2.218	NA	58.31	0.003550619	0	0.101482606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.54	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N184A	184	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Ala	0	0	NA	NA	NA	NA	NA	NA	NA	0.084	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.27	-3.116	0.846	21.06	21.06	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N184C	184	N	C	missense	wt-like	0.998046013869943	0.27726424191238	4	0.13863212095619	0.72633204969541	1.26975997804448	NA	1.08212729039968	1.08834537799532	1.22724030077524	NA	0.594471086309529	NA	NA	0.817449721301656	NA	0.807065992566223	0.827833450037088	0.833905406085763	NA	0.584340301629093	NA	NA	p.Asn184Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.27	-4.333	2.063	26.383	26.383	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N184D	184	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.27	-2.73	0.46	15.849	15.849	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.59	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N184E	184	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.27	-2.713	0.443	13.416	13.416	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.295	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N184F	184	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.27	-3.566	1.296	11.382	11.382	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N184G	184	N	G	missense	possibly_low	0.495540031530188	0.378288945402663	7	0.142979781894334	0.215304808499902	0.775775254560475	0.956710474346839	0.465622878883899	0.542489267848146	0.624272745931182	-0.167772434739693	NA	0.219842993271582	0.827614295169364	0.560116976734917	0.762293094215579	0.522867834354802	0.560116976734917	0.569473055611349	0.317459854361168	NA	0.405993255918201	0.709837214522418	p.Asn184Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.27	-2.478	0.208	20.749	20.749	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.99	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N184H	184	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.27	-3.188	0.918	32.065	32.065	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N184I	184	N	I	missense	low	0.187299939943295	0.116734457879654	3	0.0673966706805233	0.0552048927315631	0.319394987155027	NA	NA	NA	NA	0.31424006894182	0.0845668343769534	0.163092916511113	NA	0.375428039529115	NA	NA	NA	NA	0.497509757872293	0.333022421345052	0.375428039529115	NA	p.Asn184Ile	1	0	NA	NA	NA	NA	NA	NA	NA	0.971	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.27	-3.638	1.368	7.614	7.614	90.32	0.003269874	0	0.09345843	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Mar 11, 2014)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.14	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N184K	184	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.27	-2.626	0.356	15.194	15.194	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.615	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
N184L	184	N	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.27	-3.149	0.879	13.791	13.791	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N184M	184	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.27	-3.582	1.312	6.511	6.511	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N184P	184	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.27	-3.635	1.365	17.801	17.801	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N184Q	184	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.27	-2.985	0.715	18.739	18.739	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N184R	184	N	R	missense	possibly_low	0.573058992364882	0.495445658592937	3	0.286045684357464	0.012419753091141	1.13369823163862	NA	NA	NA	NA	0.0102095465003244	0.765788864341429	NA	0.943178566252893	0.668778155729674	NA	NA	NA	NA	0.383942856989162	0.668778155729674	NA	0.767879145128768	p.Asn184Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.27	-2.949	0.679	30.221	30.221	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.99	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N184S	184	N	S	missense	wt-like	0.990173389184605	0.213133424074158	5	0.0953161649014216	0.803357138833338	1.17698963953587	NA	1.33487477229465	1.02402985670316	NA	0.768776679712979	0.897958178718271	0.925227458493964	NA	0.785908668332941	NA	0.923578328091152	0.796289744253003	NA	0.667296376033751	0.733920801239866	0.785908668332941	NA	p.Asn184Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.27	-2.468	0.198	10.969	10.969	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N184T	184	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.27	-2.924	0.654	11.228	11.228	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N184V	184	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.27	-3.466	1.196	7.75	7.75	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N184W	184	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.27	-3.829	1.559	17.742	17.742	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N184X	184	N	X	nonsense	low	0.00572467154898327	0.0650852357094885	2	0.0460222115253041	-0.084477205529497	0.0959265486274635	NA	NA	NA	NA	NA	-0.0402975399763209	NA	0.0517468830742874	0.295819747804582	NA	NA	NA	NA	NA	0.271480181274445	NA	0.320159314334719	p.Asn184Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N184Y	184	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn184Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.8	82.4	53.7	0.512	105.8	-131.1	-87.1	-6.1	37.9679144385027	-2.2	1	0	54.96	1	4	0	0	6	29.5840399178341	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.27	-3.252	0.982	10.16	10.16	90.32	0.003269874	0	0.09345843	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.79	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
H185A	185	H	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.95	-2.912	-0.038	9.733	9.703	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185C	185	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.95	-4.327	1.377	20.147	20.147	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
H185D	185	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.95	-3.194	0.244	17.916	17.916	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
H185E	185	H	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.95	-2.9	-0.05	14.816	14.816	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185F	185	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.95	-3.245	0.295	12.147	12.147	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
H185G	185	H	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.95	-2.485	-0.465	21.128	21.128	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.755	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185I	185	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.95	-3.615	0.665	17.451	17.451	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H185K	185	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.95	-2.625	-0.325	24.476	24.476	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.755	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185L	185	H	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.95	-2.891	-0.059	12.393	12.393	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H185M	185	H	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.95	-3.737	0.787	4.461	4.461	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
H185N	185	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.95	-2.524	-0.426	28.293	28.293	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-1.175	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H185P	185	H	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.95	-3.331	0.381	15.1	15.1	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H185Q	185	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.95	-2.739	-0.211	19.376	19.376	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
H185R	185	H	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.95	-2.817	-0.133	28.599	28.599	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
H185S	185	H	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.95	-2.711	-0.239	19.591	19.591	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185T	185	H	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.95	-3.058	0.108	9.702	9.702	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185V	185	H	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.95	-3.445	0.495	14.697	14.697	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H185W	185	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.95	-4.362	1.412	11.952	11.952	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H185X	185	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H185Y	185	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His185Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43	84.4	53.4	0.948	52.5	156	53.2	53.2	74.537037037037	-2.7	0	0	63.05	1	2	0	0	6	29.6831975679845	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.95	-2.866	-0.084	9.294	9.294	58.31	0.00347284	0	0.099259552	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
L186A	186	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.045	-3.124	1.079	13.225	13.225	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
L186C	186	L	C	missense	wt-like	1.02376959202906	0.092884233805219	3	0.0536267373909153	0.918663118134476	1.12887606592364	1.10222140112711	NA	0.921207551455524	NA	NA	NA	NA	1.04787982350454	0.820465148145266	0.831523776415127	NA	0.74586029146136	NA	NA	NA	NA	0.820465148145266	p.Leu186Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.045	-4.292	2.247	12.832	12.832	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.035	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L186D	186	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.045	-3.253	1.208	11.222	11.222	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L186E	186	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.045	-2.956	0.911	9.951	9.951	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.23	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L186F	186	L	F	missense	possibly_low	0.623312416844962	0.13209510753042	3	0.0762651458913207	0.473835477622281	0.772789356067643	NA	0.590097479429549	0.510994739119395	0.768845031985942	NA	NA	NA	NA	0.580248530353716	NA	0.580248530353716	0.544670407569828	0.63287545447642	NA	NA	NA	NA	p.Leu186Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.045	-2.727	0.682	11.956	11.956	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.75	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L186G	186	L	G	missense	low	0.574410547164077	0.128224388556541	5	0.0573436898371545	0.462018980342618	0.686802113985535	NA	0.468630422931501	0.48373181748775	0.559241344624405	0.571296647976167	0.789152502800561	NA	NA	0.54095343434144	NA	0.524254261545107	0.531299240525147	0.54095343434144	0.593530113980348	0.680293455064829	NA	NA	p.Leu186Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.045	-2.887	0.842	37.069	37.069	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.995	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
L186H	186	L	H	missense	low	0.558580915572949	0.17450695660954	6	0.0712421667098961	0.418948834640954	0.698212996504944	0.608842075504722	0.400832327132386	0.451310014028365	0.469747612162133	0.882670443892478	NA	NA	0.53808302071761	0.5399092908417	0.596785478393219	0.493000480393766	0.515397887185157	0.501705820041783	0.709840005284886	NA	NA	0.564420694498244	p.Leu186His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.045	-3.922	1.877	9.136	9.136	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L186I	186	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.045	-2.578	0.533	17.451	17.451	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.405	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L186K	186	L	K	missense	possibly_wt-like	0.891255168665055	0.528255599530179	4	0.26412779976509	0.373574193809672	1.40893614352044	NA	NA	0.759667986459058	NA	1.65945922740996	0.456609399403285	0.689284061387918	NA	0.662731963800192	NA	NA	0.666632814044352	NA	1	0.516392041157947	0.658831113556031	NA	p.Leu186Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.045	-2.958	0.913	11.275	11.275	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.885	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L186M	186	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.045	-3.191	1.146	5.386	5.386	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.06	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
L186N	186	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.045	-2.824	0.779	11.789	11.789	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L186P	186	L	P	missense	low	0.157346415333189	0.17599084468838	5	0.0787054984281653	0.00308647302871096	0.311606357637667	NA	-0.0546650653246486	0.417412343521286	NA	0.0789689789613384	NA	0.124004351311914	0.221011468196054	0.405172123325219	NA	0.283023848291304	0.498772691217547	NA	0.40962710601907	NA	0.354375196575348	0.405172123325219	p.Leu186Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.045	-3.5	1.455	14.24	14.24	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L186Q	186	L	Q	missense	possibly_wt-like	0.791357751123642	0.208257032069211	7	0.0787137593765051	0.63708161765794	0.945633884589344	NA	0.489828475564114	0.621648609933629	0.693522872653229	1.05393143578425	0.762136877850105	1.00810698682101	0.91032899925916	0.666978191323912	NA	0.534026207054864	0.598940870977544	0.599842805414053	0.773812464152275	0.666978191323912	0.830547034695577	0.751380513934004	p.Leu186Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.045	-3.524	1.479	5.945	5.945	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L186R	186	L	R	missense	low	0.557564368149633	0.116348831621788	8	0.041135523911449	0.476940222798007	0.638188513501259	0.42241950443125	0.459046861798293	0.675086856389423	0.623758663087559	0.674748580419603	0.607326977347149	0.386052247374045	0.612075254349742	0.579962111507455	0.508089996491029	0.519836401149805	0.625149790534641	0.569247603787971	0.632173324088416	0.590676619226939	0.495512462014661	0.601583150070528	p.Leu186Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.045	-3.341	1.296	12.72	12.72	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
L186S	186	L	S	missense	possibly_low	0.662709299773147	0.260246656392097	2	0.184022175515977	0.302032463405124	1.02338613614117	NA	NA	NA	NA	0.846731475289124	NA	NA	0.47868712425717	0.615502330967562	NA	NA	NA	NA	0.696415441025866	NA	NA	0.534589220909257	p.Leu186Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.045	-3.287	1.242	8.131	8.131	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L186T	186	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.045	-3.3	1.255	11.838	11.838	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.69	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
L186V	186	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Val	1	0	yes	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.045	-2.575	0.53	11.329	11.157	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.51	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
L186W	186	L	W	missense	possibly_low	0.628138140647437	0.188138911405284	5	0.0841382790230049	0.463230144041165	0.793046137253708	NA	0.427469052988516	0.439332136570782	NA	0.83038143946531	NA	0.781916259328705	0.661591814883871	0.626452746386415	NA	0.505279562729094	0.509523307692541	NA	0.690308084162721	NA	0.70872220333565	0.626452746386415	p.Leu186Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.045	-3.422	1.377	16.757	16.757	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.465	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L186X	186	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu186Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L186Y	186	L	Y	missense	possibly_low	0.587551844350417	0.165916793069755	4	0.0829583965348774	0.424956374926865	0.750147313773969	NA	0.590288744769496	0.754220988931887	0.360634462084913	NA	NA	NA	0.645063181615374	0.599243986449768	NA	0.58033670045652	0.66396132069482	0.453854079909516	NA	NA	NA	0.618151272443015	p.Leu186Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.7	81.6	51.5	0.749	39.3	-139.4	-108.6	155.2	35.6020942408377	-3.2	0	0	53.87	0	0	0	0	5	28.8588821311568	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.045	-3.206	1.161	10.632	10.632	64.27	0.003466862	0	0.099088676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.885	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D187A	187	D	A	missense	possibly_wt-like	0.851118176629848	0.369960800564924	6	0.151035864369272	0.555093322092199	1.1471430311675	0.109524405423042	1.05150670939977	1.01461117697376	NA	1.00791369357031	1.05780852273668	NA	0.865344551675536	0.774146713140726	0.359221855516679	0.792950420056138	0.791670329587775	NA	0.756623096693678	0.812706670291009	NA	0.728787162541457	p.Asp187Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.68	-2.842	0.162	12.65	12.65	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D187C	187	D	C	missense	wt-like	0.945078846576056	0.173999455160377	7	0.0657656123735844	0.816180614902609	1.0739770782495	NA	0.625307871000442	1.02681919669949	1.02355175847026	1.13337565473193	0.793705913655373	1.02473862378932	0.988052907685584	0.79041719592095	NA	0.596479928292536	0.797657782922491	0.744577481931794	0.803487885115	0.68253770692144	0.839504724479624	0.79041719592095	p.Asp187Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.68	-4.083	1.403	13.671	13.671	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.385	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D187E	187	D	E	missense	wt-like	1.22988780170066	0.108808130231893	3	0.0628204032794033	1.10676207377875	1.35301352962257	NA	1.1456640203461	1.19125952148813	1.35273986326775	NA	NA	NA	NA	0.87830794512221	NA	0.836355355776382	0.87830794512221	0.888943432637599	NA	NA	NA	NA	p.Asp187Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.68	-2.768	0.088	26.684	26.684	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.865	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
D187F	187	D	F	missense	possibly_wt-like	0.767964829114798	0.330378722877424	8	0.116806517653189	0.539028261355006	0.996901396874589	1.03001529014474	0.805144808120968	0.92798758657469	0.979061477597856	0.0081253607643909	0.631936201046896	0.845088404090194	0.916359504578646	0.733906251902627	0.797169804291547	0.679381729728759	0.749185576380271	0.72506620068649	0.383164334777004	0.60280583351024	0.742746303118763	0.754409323513237	p.Asp187Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.68	-4.684	2.004	4.188	NA	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.385	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D187G	187	D	G	missense	possibly_low	0.70668832226816	0.21015754427112	8	0.0743019123358107	0.561059250107519	0.852317394428802	0.642307416333471	0.741065342006764	0.850340295521612	1.00099277673711	0.666680409872551	0.317657975794964	0.569891225811331	0.864571136067483	0.639500865734331	0.612707501755171	0.649842174279265	0.711103271289663	0.734684205724671	0.629159557189398	0.447906679227075	0.594526921156296	0.728398716055086	p.Asp187Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-0.197	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.68	-2.539	-0.141	18.851	18.851	58.31	0.003326265	0	0.095070205	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jun 12, 2014)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.835	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D187H	187	D	H	missense	possibly_low	0.647751000834609	0.186228498238661	8	0.0658417169773722	0.51870360687868	0.776798394790538	0.842296459467034	0.505105046444116	0.596249266410835	0.348943422434335	0.653499118591437	0.540125432334503	0.826658756190072	0.869130504804542	0.60535977334206	0.707857592507317	0.541068449132595	0.586483700405103	0.448726956452448	0.624235846279017	0.557554812965509	0.732820216526502	0.730688650144263	p.Asp187His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.68	-3.594	0.914	29.43	29.43	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.835	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
D187I	187	D	I	missense	wt-like	1.12036474992764	0.0878654890746072	3	0.0507291637697026	1.02093741597318	1.21979208388209	NA	1.21980793233529	1.05321805399534	1.08806826345227	NA	NA	NA	NA	0.810605167486066	NA	0.870534451394058	0.810605167486066	0.772871294624917	NA	NA	NA	NA	p.Asp187Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.475	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.68	-3.026	0.346	11.926	11.926	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.58	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D187K	187	D	K	missense	possibly_wt-like	0.859347292276032	0.2987144945112	7	0.112903466498143	0.638060564209947	1.08063402034212	NA	0.777941074872145	0.891659724844976	0.263005571439427	0.941544721795593	0.858633258053549	1.08515545991536	1.19749123501118	0.731368487143575	NA	0.666841266527884	0.731368487143575	0.411038779450651	0.731831775155543	0.714538621808456	0.872044833236315	0.89560718887436	p.Asp187Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.68	-2.907	0.227	10.313	10.313	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.16	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187L	187	D	L	missense	wt-like	0.934983072450531	0.0759505053965247	8	0.026852558700214	0.882353024505364	0.987613120395698	0.787382480483462	1.02495186888838	0.86876176191578	0.931137267232629	0.946598866200612	0.99929938028207	0.945252890094357	0.976480064506962	0.757214387381858	0.681730810749785	0.780709085486642	0.7201381248425	0.704048964369712	0.733719689277074	0.783869111860777	0.796694233482646	0.784604757920919	p.Asp187Leu	0	0	NA	NA	NA	NA	NA	NA	NA	-0.884	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.68	-3.058	0.378	18.077	18.077	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.58	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D187M	187	D	M	missense	wt-like	0.970101027802244	0.191353328047428	6	0.0781196690499331	0.816989289980187	1.1232127656243	1.2225352414934	0.79857219527979	0.772960454538041	NA	0.903271787701198	1.18379801381927	0.939468473981774	NA	0.755557085839976	0.888766276555228	0.676351865823151	0.673152137744196	NA	0.717535386497259	0.874803449670537	0.793578785182693	NA	p.Asp187Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.68	-3.995	1.315	12.781	12.781	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.385	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187N	187	D	N	missense	wt-like	1.06234991349049	0.0956419585740214	6	0.0390456660844598	0.985821814212571	1.13887801276841	1.18591185507363	1.07829516307876	1.04726520745626	0.909214657499755	1.13204593308038	NA	1.02136666475415	NA	0.806492512803683	0.871341729255582	0.805299446364293	0.807685579243072	0.69443477008409	0.802991183777942	NA	0.837688609622189	NA	p.Asp187Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.68	-2.389	-0.291	13.203	13.203	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.38	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D187P	187	D	P	missense	wt-like	0.964580755663449	0.17385719939518	8	0.0614678023252168	0.844106076897197	1.0850554344297	1.00265597159178	1.12717788782746	0.605971565447198	1.1839249519119	1.00167447254802	0.964126111241439	0.89553752910504	0.93557755563475	0.768225518330978	0.78415288295205	0.827833559798743	0.591252025907042	0.814909393083845	0.75429251162697	0.766533168133207	0.76991786852875	0.764061552314831	p.Asp187Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.68	-2.675	-0.005	19.396	19.396	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.38	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187Q	187	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp187Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.68	-2.799	0.119	17.89	17.89	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187R	187	D	R	missense	possibly_low	0.677800429817137	0.281311169434855	8	0.0994585177654518	0.482865317041114	0.87273554259316	0.97910253658347	0.936611417863674	0.65056175445531	0.884234713946784	0.13355266657045	0.586575266097312	0.479407151735297	0.7723579312848	0.647603103514227	0.77294671163661	0.739985624295084	0.613121393902044	0.683479777339682	0.430016178112095	0.580448667481471	0.54579279669734	0.68208481312641	p.Asp187Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.68	-3.084	0.404	13.488	13.488	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.49	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D187S	187	D	S	missense	wt-like	1.05003005715265	0.182613130218565	7	0.0690212755276254	0.91475084295149	1.18530927135381	1.37708250216769	1.09890351175717	1.03249886773065	0.761653269813532	1.07178575794218	NA	1.04006254390115	0.968223946756194	0.800443391564972	0.962296234238128	0.814799548275619	0.800443391564972	0.629721496091719	0.780481728864785	NA	0.847758086605003	0.780458138822516	p.Asp187Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.68	-2.925	0.245	17.026	17.026	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.145	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187T	187	D	T	missense	wt-like	0.939929636126967	0.0805166405347523	5	0.0360081363111242	0.869354985806754	1.01050428644718	NA	0.984712397932104	0.955970531504896	1.0012329684261	0.799956977781068	NA	NA	0.957775304990661	0.76215936658835	NA	0.76215936658835	0.762909880624669	0.734789542160065	0.678943396838665	NA	NA	0.775210328797847	p.Asp187Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.68	-2.609	-0.071	12.265	12.265	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.065	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D187V	187	D	V	missense	possibly_wt-like	0.846217168014407	0.226575690666364	8	0.0801066036611059	0.689211109914815	1.003223226114	1.03517577983191	0.938220543513157	0.884219948378665	0.695334675712265	0.776619516357834	0.390678912982924	0.938507371387273	1.11098059595123	0.734223517297537	0.79962504411052	0.740727404138621	0.727719630456452	0.600637374437956	0.670225972196453	0.483896704964022	0.793061141675407	0.852157388499645	p.Asp187Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.68	-2.976	0.296	9.353	9.353	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.58	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D187W	187	D	W	missense	low	0.582822309578513	0.105752352781034	6	0.0431732172353886	0.498204358700428	0.667440260456599	0.652499223879962	0.74335932022074	0.601203634367033	0.498766287515718	0.547194574748011	0.453910816739615	NA	NA	0.586720330137042	0.617556524470527	0.650899659629266	0.588913582368532	0.514432004841871	0.584527077905552	0.515061983461362	NA	NA	p.Asp187Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.68	-3.9	1.22	31.912	31.912	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D187X	187	D	X	nonsense	low	0.04919361162465	0.335211039484113	4	0.167605519742056	-0.279307170679898	0.377694393929197	NA	0.499680476720923	NA	NA	-0.310832130497472	0.0189757943293199	-0.0110496940541709	NA	0.291165184528156	NA	0.538567813783319	NA	NA	0.264021646387753	0.300694388997958	0.281635980058354	NA	p.Asp187Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D187Y	187	D	Y	missense	possibly_wt-like	0.841721178870998	0.267748522162973	7	0.101199429078327	0.64337394262146	1.04006841512053	0.877191918490086	0.752375472562516	0.956595007281035	1.14731885973914	1.02676595230325	NA	0.818796962281637	0.313004079439315	0.72858590627117	0.724460032525312	0.655055954120958	0.763216156306745	0.798855734943933	0.763665128466521	NA	0.72858590627117	0.451375233577341	p.Asp187Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.6	81.7	49.1	0.942	30.1	-111.1	-113.2	137.5	66.8449197860963	-0.3	0	0	45.08	0	0	0	0	3	27.823244919671	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.68	-4.027	1.347	7.876	7.876	58.31	0.003326265	0	0.095070205	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	0.835	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Y188A	188	Y	A	missense	low	0.219201089891019	0.175604667966572	8	0.0620856257635876	0.097515499436755	0.340886680345283	-0.0239365879108998	0.364849158406895	0.43328768513769	0.414593061165867	0.0817920322067404	0.0920682137325526	0.107873395643727	0.283081760745578	0.42351421517456	0.295724248704714	0.476412845192175	0.506558791603718	0.477517706697815	0.410681623195614	0.336719646366633	0.34568717043149	0.436346807153505	p.Tyr188Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.116	-2.897	0.781	8.553	8.553	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y188C	188	Y	C	missense	low	0.241309349765588	0.127870218986029	8	0.0452089494784151	0.152701437009004	0.329917262522173	0.366506451680414	0.426118024429726	0.356733423997238	0.198136228618909	0.144906278365196	0.183243723189465	0.0538235829953698	0.20100708484839	0.414691071127805	0.481487878894424	0.504656761300706	0.469012565725163	0.382590229179656	0.434257181597551	0.381657564973279	0.316576298452241	0.395124960658059	p.Tyr188Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.116	-5.417	3.301	1.037	NA	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y188D	188	Y	D	missense	low	0.304958253638366	0.135015752401778	7	0.0510311577044822	0.204939022448197	0.404977484828535	0.305971396898169	0.389175237323765	0.250212095709277	0.277185630697897	0.359950005551315	NA	0.492699198338093	0.0595142109500458	0.452686721261154	0.452686721261154	0.487626758175673	0.416768917975161	0.417257466292854	0.514584148294076	NA	0.552951805175567	0.324060439668134	p.Tyr188Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.116	-3.679	1.563	12.01	12.01	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y188E	188	Y	E	missense	low	0.318525962101407	0.142438026063173	8	0.0503594470640478	0.219823259574522	0.417228664628292	0.148195224379749	0.322331159001667	0.262451045723841	0.38388774443757	0.610001097978877	0.176325133559458	0.336035789051969	0.308980502678127	0.453083581496263	0.37762052314135	0.456812763025544	0.422771541146196	0.464051842723385	0.607987690153608	0.378247581091445	0.468573928026723	0.449354399966982	p.Tyr188Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.116	-2.911	0.795	9.14	9.14	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188F	188	Y	F	missense	possibly_wt-like	0.709798320564916	0.19018630760655	5	0.0850539024395862	0.543095735038744	0.876500906091089	1.00520246806957	0.484516781101867	0.631425147759539	0.698246328100422	NA	NA	NA	0.729600877793183	0.603735798027371	0.785364446181541	0.531577605301244	0.603735798027371	0.60191428408024	NA	NA	NA	0.66061016608867	p.Tyr188Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.116	-2.916	0.8	14.251	14.251	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y188G	188	Y	G	missense	low	0.166989245791292	0.131315197288742	8	0.0464269332378595	0.0759941287324414	0.257984362850142	0.174643339688566	0.097102864371881	0.19955682284617	0.444204847652081	0.00896369158169865	0.0848168670406787	0.108074508955147	0.21855102419411	0.386840699211352	0.390203915373376	0.35298630969408	0.391924914669209	0.490504001299224	0.383477483049328	0.333145655616606	0.345795488732243	0.40393637010597	p.Tyr188Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.116	-3.24	1.124	13.537	13.537	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y188H	188	Y	H	missense	low	0.185608992317846	0.214578675098629	2	0.151730036260266	-0.111776414125231	0.482994398760924	NA	NA	NA	NA	0.0338789560575807	NA	NA	0.337339028578112	0.42819084565745	NA	NA	NA	NA	0.39278427681624	NA	NA	0.463597414498659	p.Tyr188His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.116	-3.474	1.358	10.454	10.454	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y188I	188	Y	I	missense	possibly_wt-like	0.983658988533373	0.451641193583384	5	0.201980082058318	0.587785302104626	1.37953267496212	0.999004830528737	1.06152110528827	0.429997714289384	0.768312065150508	1.65945922740996	NA	NA	NA	0.78241575576721	0.78241575576721	0.797566888022874	0.504945217300157	0.632641721049329	1	NA	NA	NA	p.Tyr188Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.116	-2.871	0.755	17.451	17.451	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188K	188	Y	K	missense	possibly_low	0.545543697669416	0.618055816266756	2	0.43703145883401	-0.311022221756243	1.40210961709507	0.982575156503426	NA	NA	NA	NA	NA	NA	0.108512238835406	0.561634253311076	0.774598902653449	NA	NA	NA	NA	NA	NA	0.348669603968703	p.Tyr188Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.116	-3.044	0.928	9.351	8.732	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188L	188	Y	L	missense	low	0.456549720256419	0.199969546901391	8	0.0706999113223875	0.317980440354364	0.595119000158474	0.686116561988381	0.449106044399776	0.461823134967324	0.592769910025412	0.210576258132825	0.422019389630791	0.147200891800357	0.682785571106484	0.517903962432577	0.633550864569076	0.515253851628662	0.520554073236493	0.555657438372497	0.458787403179836	0.499343569994822	0.366868700020287	0.637097269269026	p.Tyr188Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.116	-2.379	0.263	11.927	11.927	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y188M	188	Y	M	missense	low	0.29266368323695	0.164606868713388	6	0.0672004727508501	0.160953176901219	0.424374189572682	0.439262771883864	0.129148604584723	0.167650345557227	0.333512374849398	0.163144240775946	NA	0.523263761770544	NA	0.441514698604165	0.516103627645855	0.367758856616525	0.376276304318418	0.441959646751642	0.441069750456688	NA	0.569413677096797	NA	p.Tyr188Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.116	-3.331	1.215	5.305	5.305	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y188N	188	Y	N	missense	low	0.136788436713496	0.292642455119543	2	0.206929464478109	-0.268785861003758	0.54236273443075	NA	NA	NA	NA	-0.0701410277646133	NA	NA	0.343717901191605	0.410365034452296	NA	NA	NA	NA	0.353928878030175	NA	NA	0.466801190874417	p.Tyr188Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.116	-3.137	1.021	11.789	11.789	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y188P	188	Y	P	missense	low	0.222082914467951	0.288245442095162	7	0.10894653661881	0.00855162645470994	0.435614202481192	NA	0.228928204008079	0.489152485920962	0.659689189795487	-0.112852974691513	-0.027995417384065	-0.00383141958496739	0.321490333211676	0.413755572704039	NA	0.413755572704039	0.533957820705716	0.585004991652096	0.337974350161658	0.277543561528997	0.28552369499552	0.455637438045426	p.Tyr188Pro	0	0	NA	NA	NA	NA	NA	NA	NA	2.229	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.116	-2.93	0.814	15.223	15.223	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188Q	188	Y	Q	missense	low	0.291483708570157	0.150107924421605	6	0.0612813035301991	0.171374560725299	0.411592856415014	NA	0.17156119925231	0.314260384017534	0.362104650626323	0.53277949226337	NA	0.108310667995979	0.259885857265425	0.436439134192655	NA	0.38731034897302	0.448181558684274	0.454498833360216	0.579142499309269	NA	0.345922682431306	0.424696709701036	p.Tyr188Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.116	-3.042	0.926	7.644	7.644	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188R	188	Y	R	missense	low	0.212911019959539	0.213768568885921	8	0.0755786023318893	0.0647796813871609	0.361042358531917	0.183674985542015	0.205212735560631	0.243999753974945	0.305865447009721	-0.143851482557173	0.619602322637013	0.0840141956053996	0.204770201903759	0.399919059878947	0.394500960397102	0.402823140870641	0.413722059674692	0.429835043937925	0.326395234874041	0.596726801680432	0.33283676293125	0.397014978887253	p.Tyr188Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.116	-3.154	1.038	26.635	26.635	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188S	188	Y	S	missense	low	0.334501266454587	0.155353891686947	5	0.0694763724762308	0.198330078624684	0.470672454284489	NA	0.240800586444353	0.30290936194596	0.317907205700967	0.60091861278531	NA	NA	0.209970565396344	0.435115975770809	NA	0.419228541200201	0.442614421959254	0.435115975770809	0.604595038365007	NA	NA	0.399626851346918	p.Tyr188Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.116	-3.39	1.274	6.931	6.931	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
Y188T	188	Y	T	missense	low	0.485096814763941	0.10888061382363	4	0.0544403069118151	0.378395773909476	0.591797855618405	NA	0.628901787278194	0.479773935803038	0.467178842340396	NA	NA	NA	0.364532693634133	0.514968684892353	NA	0.598136663212554	0.52935808770725	0.500579282077456	NA	NA	NA	0.477255379934819	p.Tyr188Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.116	-3.162	1.046	6.956	6.956	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y188V	188	Y	V	missense	low	0.428481368999249	0.0930220516160153	6	0.0379760935476795	0.354049593372273	0.502913144626224	0.387619302177602	0.444075650433693	0.49464722231234	0.557623419155907	0.289423313262168	NA	NA	0.397499306653782	0.503373860969142	0.491532877407179	0.512934924669609	0.536652727698748	0.540243890633673	0.488239760867127	NA	NA	0.493812797268676	p.Tyr188Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.116	-2.776	0.66	11.329	9.019	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
Y188W	188	Y	W	missense	low	0.391347521352116	0.126139021921901	4	0.0630695109609506	0.267733551346099	0.514961491358134	NA	0.368816614885701	0.482191725441622	0.492541332597634	NA	NA	NA	0.221840412483508	0.494971908563483	NA	0.478241775858362	0.530543898588901	0.511702041268604	NA	NA	NA	0.405588458982926	p.Tyr188Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.116	-3.742	1.626	14.293	14.293	77.42	0.002510071	0	0.071741997	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y188X	188	Y	X	nonsense	low	-0.051127127541205	0.0641165991939448	7	0.0242337966254832	-0.0986244961358204	-0.00362975894658966	NA	-0.093814697376202	-0.0334961041435882	0.0666034888315113	-0.134423717384145	-0.0838791416981843	-0.0533655451428369	-0.0255141758749902	0.277623532772753	NA	0.264976526786579	0.277623532772753	0.324906343426772	0.329916861796091	0.25	0.258844942247558	0.281355097598338	p.Tyr188Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.4	79.6	46	0.264	36	176.4	-64.3	154.1	14.5098039215686	-0.5	0	0	35.48	0	0	0	0	3	25.6691592745068	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R189A	189	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg189Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.465	-3.105	0.64	12.003	12.003	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.06	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R189C	189	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg189Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.465	-3.794	1.329	19.428	19.428	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R189D	189	R	D	missense	possibly_low	0.451913379705894	0.352380029598144	5	0.157589140018968	0.143044340914078	0.760782418497711	0.601319570075885	0.897911632541037	0.198477306203367	0.00456976992523	NA	NA	NA	0.557288619783952	0.574066669312175	0.593206446947185	0.722145674561668	0.391395463073615	0.297701360393648	NA	NA	NA	0.574066669312175	p.Arg189Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.465	-4.095	1.63	3.808	NA	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R189E	189	R	E	missense	wt-like	0.922346523158552	0.0964489957477051	6	0.039375137630957	0.845172671515569	0.999520374801536	NA	0.867075139239846	0.957673688654982	0.887086672689023	1.05428118446705	NA	0.985507838204031	0.782454615696376	0.735837884178537	NA	0.707930570114402	0.763745198242672	0.684730508241549	0.773943108515463	NA	0.818375282565574	0.687155853253919	p.Arg189Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.465	-2.849	0.384	12.015	12.015	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.06	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R189F	189	R	F	missense	possibly_wt-like	0.95025029110146	0.477601173424702	3	0.275743166042033	0.409803616676028	1.49069696552689	NA	NA	NA	NA	1.42044875745207	0.964726562609208	NA	0.4655755532431	0.766829114214044	NA	NA	NA	NA	0.910720548273369	0.766829114214044	NA	0.528003959843673	p.Arg189Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.465	-3.102	0.637	12.338	12.338	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R189G	189	R	G	missense	low	0.590704609193002	0.085431074805563	8	0.0302044461595344	0.531504982547335	0.649904235838668	0.441922517106108	0.655924805266294	0.653694376619578	0.679284889902133	0.499624309969994	0.544759878654271	0.618244759338742	0.632181336686893	0.60209626792724	0.517369071968748	0.610593819719593	0.614657796156074	0.593598716134887	0.566757784541038	0.559839004989717	0.620569814836957	0.611681390857554	p.Arg189Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.465	-3.379	0.914	37.069	37.069	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.92	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
R189H	189	R	H	missense	wt-like	0.957884838873589	0.281315946225041	7	0.10632743336404	0.749486898911489	1.16628277883569	NA	0.808448993931863	0.952435586658932	0.569348416269745	1.40205873341849	0.745923645907474	1.18720217639023	1.03977631953838	0.761176158220749	NA	0.680904903779592	0.761176158220749	0.545385906188589	0.903851178645977	0.658987132083021	0.927006520495616	0.81639517902365	p.Arg189His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.465	-3.533	1.068	13.968	13.968	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R189I	189	R	I	missense	possibly_low	0.666516404072105	0.460651082021449	7	0.174109743457367	0.325267577538157	1.00776523060605	0.894054651535831	0.821665883781677	0.882282585722478	1.07918987643366	-0.156609464704003	0.194832857039864	NA	0.950198438695223	0.72676944617129	0.732482924952275	0.686997667565928	0.72676944617129	0.768977664314477	0.321629645938093	0.387369532548704	NA	0.771404862423075	p.Arg189Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.465	-3.282	0.817	9.702	9.702	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.61	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.642857142857143
R189K	189	R	K	missense	wt-like	0.94460025969136	0.134105787751449	3	0.0774260126581859	0.792848063414774	1.09635245596795	NA	NA	NA	NA	0.824716420771638	0.919658369252989	NA	1.08942598904945	0.744616232521867	NA	NA	NA	NA	0.688191985386457	0.744616232521867	NA	0.841331629064571	p.Arg189Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.465	-2.477	0.012	25.095	25.095	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.75	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
R189L	189	R	L	missense	low	0.639096368758542	0.0455385936145885	8	0.016100324175287	0.60754031323556	0.670652424281524	0.638921954790154	0.638354981082571	0.652905024434927	0.721789671851228	0.568137133965866	0.612732665857227	0.610340975536746	0.66958854254962	0.611668016207335	0.611096778647359	0.602494426463289	0.614270656433462	0.612239253767311	0.592349915980604	0.593340935464115	0.616312889102385	0.630469087318621	p.Arg189Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.465	-2.787	0.322	11.554	11.554	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
R189M	189	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg189Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.465	-3.383	0.918	5.707	5.707	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R189N	189	R	N	missense	possibly_wt-like	0.778526573062861	0.132378248504737	4	0.0661891242523686	0.648798273359972	0.90825487276575	NA	NA	0.770268647528223	0.646817039310097	0.735902659568198	NA	NA	0.961117945844927	0.663424310165909	NA	NA	0.671831934368101	0.579359890218085	0.655016685963716	NA	NA	0.776889163672036	p.Arg189Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.465	-2.932	0.467	14.461	14.461	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R189P	189	R	P	missense	low	0.221199074832871	0.16098623410884	7	0.0608470771366878	0.101940995080432	0.34045715458531	0.458006213208466	0.156911647288601	0.245814444269488	0.385227635441063	0.00715585076271786	0.0730033657926004	NA	0.222274367067162	0.405806411829377	0.525021316910723	0.380557152063249	0.414612078998026	0.464639453988015	0.382802186117123	0.327323103478342	NA	0.405806411829377	p.Arg189Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.465	-2.542	0.077	16.696	16.696	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
R189Q	189	R	Q	missense	possibly_wt-like	1.10492469831901	0.355457552006398	3	0.205223513336379	0.702694003398933	1.50715539323909	NA	1.38388262703992	1.22618876220896	NA	0.704702705708161	NA	NA	NA	0.895439077241224	NA	0.94617012434814	0.895439077241224	NA	0.643362322976977	NA	NA	NA	p.Arg189Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.465	-2.853	0.388	9.077	9.077	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R189R	189	R	R	synonymous	possibly_wt-like	0.79222557213813	0.399411925234018	8	0.141213440409874	0.515452314801783	1.06899882947448	1.08347359705095	1.02819085576595	1.06033252153494	1.08838699968999	0.568517872872951	0.0549649153630966	0.399481524270655	1.0544562905565	0.777606640409846	0.822604011455511	0.782202203926484	0.814094475609061	0.773011076893209	0.592492136364847	0.318432443892018	0.502745381822441	0.823768165943813	p.Arg189=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R189S	189	R	S	missense	possibly_wt-like	0.822908554704907	0.296303440975194	8	0.104759086201234	0.617584518697162	1.02823259071265	0.28378880483832	0.957209638624775	0.897994091154112	0.457493087164341	1.07086114735154	1.03449854869539	1.06860019616865	0.812822923642123	0.741978125052101	0.442132764831636	0.749481057406981	0.734475192697221	0.496331579217247	0.780136351833364	0.801217820681834	0.863128277564816	0.702408276913004	p.Arg189Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.465	-2.839	0.374	8.731	8.731	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
R189T	189	R	T	missense	wt-like	1.02781943072384	0.289299124038551	7	0.109344790959262	0.813507578546622	1.24213128290105	NA	1.15155531342532	1.14680873575884	1.34050497429753	1.13290475607424	0.967812069952921	1.02756298301826	0.427587182539752	0.839071142738035	NA	0.839071142738035	0.856506947808563	0.883577803223218	0.80331198665338	0.768349876518503	0.841025905699472	0.508924374470627	p.Arg189Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.465	-2.736	0.271	9.58	9.58	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
R189V	189	R	V	missense	wt-like	0.892217237876027	0.1770227415906	7	0.0669083072359398	0.761079365427044	1.02335511032501	0.813437074682305	0.991722291045955	1.08695184107782	1.11495427493243	0.631969913086333	NA	0.823488045029927	0.782997225277416	0.731112492444891	0.694126974878009	0.765390809340425	0.827149986424545	0.784662196396437	0.616193873624244	NA	0.731112492444891	0.687428377861687	p.Arg189Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.465	-2.848	0.383	11.223	11.223	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.06	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R189W	189	R	W	missense	possibly_wt-like	0.742718829697304	0.164571233429192	6	0.067185924706997	0.61103683700357	0.874400822391038	NA	0.530361054989384	0.879423565272194	0.911518388544066	0.865156494591419	0.585369185111069	0.684484289675694	NA	0.675845531554277	NA	0.552711044024478	0.725367232551583	0.695445074884098	0.703297882709912	0.579854223101444	0.656245988224456	NA	p.Arg189Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.465	-4.374	1.909	11.459	11.459	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R189X	189	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg189Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R189Y	189	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg189Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.8	76.6	45.6	0.901	39.8	-102.6	-158.3	127.9	71.6981132075472	-0.2	0	0	41.45	0	0	0	0	3	27.653408069531	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.465	-3.39	0.925	11.026	11.026	58.31	0.003132993	0	0.08954615	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P190A	190	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.721	-2.647	0.926	12.003	12.003	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.81	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
P190C	190	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.721	-4.167	2.446	13.791	13.791	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190D	190	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.721	-2.919	1.198	28.844	28.844	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P190E	190	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.721	-2.875	1.154	12.826	12.826	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
P190F	190	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.721	-3.878	2.157	11.765	11.765	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190G	190	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.721	-2.963	1.242	15.435	15.435	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P190H	190	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.721	-5.029	3.308	3.649	NA	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190I	190	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.721	-3.67	1.949	7.209	7.209	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190K	190	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.721	-2.461	0.74	10.519	10.519	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.81	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P190L	190	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.721	-3.001	1.28	13.884	13.884	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P190M	190	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.721	-4.056	2.335	4.582	4.582	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190N	190	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.721	-3.273	1.552	9.745	9.745	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190Q	190	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.721	-2.902	1.181	11.679	11.679	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.26	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
P190R	190	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.721	-2.867	1.146	13.83	13.83	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P190S	190	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.721	-3.234	1.513	7.367	7.367	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.81	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P190T	190	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.721	-2.769	1.048	11.838	11.838	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.465	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P190V	190	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.721	-3.043	1.322	10.555	10.555	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P190W	190	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.721	-4.236	2.515	14.293	14.293	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.81	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P190X	190	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P190Y	190	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro190Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.7	74.1	42.7	0.362	37.5	-156.1	-58.2	125.7	58.4415584415584	-0.6	0	0	38.07	0	0	0	0	4	26.6910737487273	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.721	-3.866	2.145	24.573	24.573	43.18	0.002986563	0	0.085360944	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V191A	191	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.197	-2.589	0.392	8.985	8.985	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
V191C	191	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.197	-3.758	1.561	24.824	24.824	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V191D	191	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.197	-3.493	1.296	11.419	11.419	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.71	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
V191E	191	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.197	-2.909	0.712	11.868	11.868	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
V191F	191	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.197	-3.725	1.528	12.147	12.147	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V191G	191	V	G	missense	low	0.143288635931795	0.190292646531875	2	0.134557220772624	-0.120438670642352	0.407015942505942	NA	NA	NA	0.00873141515917125	NA	NA	NA	0.277845856704418	0.366621770423661	NA	NA	NA	0.299526456324948	NA	NA	NA	0.433717084522374	p.Val191Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.197	-3.371	1.174	21.128	21.128	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
V191H	191	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.197	-4.191	1.994	7.291	7.291	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V191I	191	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.197	-2.571	0.374	10.646	10.646	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V191K	191	V	K	missense	wt-like	1.00249578519381	0.208359956696416	3	0.120296677087014	0.766718630643413	1.2382729397442	NA	NA	NA	NA	0.771971315456335	1.05811136723335	1.17740467289173	NA	0.81285593407273	NA	NA	NA	NA	0.668489693329363	0.81285593407273	0.921729649844524	NA	p.Val191Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.197	-2.716	0.519	13.819	13.819	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V191L	191	V	L	missense	wt-like	1.22176909953786	0.215564786989545	3	0.124456387796218	0.977839061811322	1.4656991372644	NA	NA	NA	NA	0.998081953392948	1.42817071233728	NA	1.23905463288335	0.916482324696547	NA	NA	NA	NA	0.752950569826098	0.995248078947643	NA	0.916482324696547	p.Val191Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.197	-2.619	0.422	14.243	11.648	72.21	0.003225327	0	0.092185227	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Oct 31, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
V191M	191	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.197	-3.676	1.479	11.696	11.696	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V191N	191	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.197	-3.412	1.215	7.781	7.781	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V191P	191	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.197	-2.795	0.598	15.468	15.468	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V191Q	191	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.197	-3.054	0.857	10.298	10.298	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.165	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V191R	191	V	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.197	-2.545	0.348	15.11	15.11	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.165	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V191S	191	V	S	missense	possibly_wt-like	0.809108833905304	0.259942540444528	2	0.183807133067184	0.448853472992062	1.16936419481855	NA	0.62530170083812	0.992915966972488	NA	NA	NA	NA	NA	0.688753472186664	NA	0.596477083951547	0.781029860421781	NA	NA	NA	NA	NA	p.Val191Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.197	-2.884	0.687	15.989	15.989	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.02	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V191T	191	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.197	-2.597	0.4	13.486	13.486	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.815	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
V191W	191	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.197	-5.821	3.624	0.574	NA	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V191X	191	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V191Y	191	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val191Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.1	70.9	44	0.922	2.7	-147.2	-112	115.6	24.8484848484848	-0.9	0	0	27.91	0	0	0	0	6	28.5204666487069	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.197	-4.62	2.423	2.817	NA	72.21	0.003225327	0	0.092185227	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A192A	192	A	A	synonymous	wt-like	0.939862374472576	0.215190769814185	7	0.0813344659092683	0.780449750588609	1.09927499835654	1.01690393441772	0.997312205953138	1.17104721616337	0.975503776954515	0.963697053020923	0.975222138325576	NA	0.479350296472789	0.767967666036834	0.790931729106214	0.767967666036834	0.868394770206221	0.723505965586201	0.740106508838183	0.772002096850296	NA	0.534922297865985	p.Ala192=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	0	1.8	1.8	0	121	121	0	8.1	8.1	0	89	89	0	6	6	0	NA	NA	NA	NA	NA	NA	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
A192C	192	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-2.391	-3.95	1.559	16.31	16.31	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A192D	192	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-2.391	-3.604	1.213	12.699	12.699	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A192E	192	A	E	missense	wt-like	0.95188351536479	0.274506161801877	6	0.112066671277413	0.732236875793771	1.17153015493581	NA	1.40119461534158	1.1874777323282	0.787958960867077	0.807706522319673	0.744321000454688	0.782642260877521	NA	0.695475683921866	NA	0.954150659602078	0.876453157316691	0.641257897445755	0.681838144870664	0.658197231907616	0.709113222973068	NA	p.Ala192Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-2.391	-2.857	0.466	10.615	10.615	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
A192F	192	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-2.391	-4.615	2.224	4.986	NA	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.3	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A192G	192	A	G	missense	wt-like	1.08988871815417	0.108090053001295	3	0.0624058211970186	0.967575556182372	1.21220188012598	NA	NA	NA	NA	0.969315785992759	NA	1.12224517205583	1.17810519641393	0.885870588656631	NA	NA	NA	NA	0.742205318146462	NA	0.8920211071393	0.885870588656631	p.Ala192Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-2.391	-3.173	0.782	14.676	14.676	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.3	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.642857142857143
A192H	192	A	H	missense	wt-like	1.2162883512025	0.097585595715819	3	0.0563410699555581	1.10586188323916	1.32671481916585	NA	1.14047482604901	1.18199968079307	1.32639054676543	NA	NA	NA	NA	0.873766433452491	NA	0.833963224537274	0.873766433452491	0.877387899275769	NA	NA	NA	NA	p.Ala192His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-2.391	-4.14	1.749	8.697	8.697	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A192I	192	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-2.391	-3.226	0.835	19.741	19.741	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A192K	192	A	K	missense	wt-like	0.981435167952122	0.132871984716125	7	0.0502208896809203	0.883004032905959	1.07986630299828	NA	0.967658788057322	0.805497349800068	0.864262688077415	1.03177385354468	1.15538522311919	1.13420762401734	0.911260649048851	0.754297939440808	NA	0.754297939440808	0.689109938142187	0.674721014613653	0.765535769017182	0.86079956108825	0.898464004728507	0.751848433230649	p.Ala192Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-2.391	-2.42	0.029	9.282	9.282	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A192L	192	A	L	missense	possibly_low	0.40796185891543	0.453065769752155	3	0.261577644127012	-0.104720902734348	0.920644620565208	NA	0.905113919888302	NA	NA	NA	0.0183239167592166	NA	0.300447740098771	0.445068836540951	NA	0.725465807817438	NA	NA	NA	0.300373096346442	NA	0.445068836540951	p.Ala192Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-2.391	-2.625	0.234	12.185	11.182	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A192M	192	A	M	missense	possibly_wt-like	0.950324904122758	0.567835003504469	4	0.283917501752234	0.39385682610779	1.50679298213772	1.32136766555411	NA	1.16930220341215	NA	NA	0.104123369304259	NA	1.20650637822051	0.883836975720046	0.935788423225288	NA	0.867538924405579	NA	NA	0.34266130332143	NA	0.900135027034514	p.Ala192Met	0	0	NA	NA	NA	NA	NA	NA	NA	-0.21	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-2.391	-3.662	1.271	6.752	6.752	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A192N	192	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-2.391	-3.351	0.96	10.453	10.453	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A192P	192	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-2.391	-2.63	0.239	44.195	44.195	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
A192Q	192	A	Q	missense	wt-like	1.0217176270593	0.0891827572618726	5	0.039883741531682	0.943546930088499	1.0998883240301	NA	1.0742432360451	1.05936912861085	0.876050411389809	1.09885482474084	NA	NA	1.00007053450991	0.796453025642804	NA	0.803431576193919	0.813621977177245	0.67989053883962	0.790593049272474	NA	NA	0.796453025642804	p.Ala192Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-2.391	-3.004	0.613	7.538	7.538	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A192R	192	A	R	missense	wt-like	1.46242384532063	0.197559322285354	2	0.139695536474592	1.18862562502942	1.73622206561183	NA	NA	NA	NA	1.60211938179522	NA	1.32272830884603	NA	0.989290699316487	NA	NA	NA	NA	0.978581398632973	NA	1	NA	p.Ala192Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-2.391	-2.568	0.177	14.001	14.001	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.3	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A192S	192	A	S	missense	wt-like	1.08234398793951	0.169941693906426	8	0.0600834620837814	0.964582566188817	1.2001054096902	0.852512374275231	1.19765524522265	1.21402813327334	1.29302954599637	1.01095503112702	0.956318361466566	1.22971642892711	0.904536783227764	0.811503688477015	0.712718084891727	0.860322435455083	0.889474866836212	0.862757380972304	0.757759151317673	0.762684941498947	0.94990441601556	0.74847138468671	p.Ala192Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-2.391	-2.548	0.157	17.026	17.026	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
A192T	192	A	T	missense	possibly_wt-like	0.975589511555919	0.274302697425135	3	0.158368736197842	0.665192492331024	1.28598653078082	1.29222056584895	NA	NA	NA	0.810164033096898	NA	NA	0.824383935721905	0.708214772766631	0.921920917592716	NA	NA	NA	0.682756118107743	NA	NA	0.708214772766631	p.Ala192Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-2.391	-2.419	0.028	13.486	13.486	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.02	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
A192V	192	A	V	missense	possibly_wt-like	1.00891315786048	0.650944531807452	4	0.325472265903726	0.370999238722533	1.64682707699843	NA	1.40898201873155	1.28000582291272	1.31067497430428	NA	NA	NA	0.0359898154933638	0.896164798965498	NA	0.957740521506291	0.921833787179008	0.870495810751989	NA	NA	NA	0.312245357758724	p.Ala192Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-2.391	-2.781	0.39	12.817	11.223	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	1.955	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
A192W	192	A	W	missense	possibly_wt-like	0.731327095037965	0.250187445904316	8	0.0884546197833422	0.55795922599643	0.9046949640795	0.475235056296536	0.988382609933539	1.10107123200438	0.750078868814919	0.372545278929232	0.777327011284583	0.826504602136201	0.559472100904327	0.649555258973103	0.533218395899143	0.763851272552962	0.834074876471143	0.624645524695234	0.51928895934995	0.674464993250972	0.7327371901716	0.575163318462305	p.Ala192Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-2.391	-5.8	3.409	1.044	NA	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A192X	192	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala192Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A192Y	192	A	Y	missense	wt-like	1.08636620217133	0.177306973187432	5	0.079294088986366	0.930952643571138	1.24177976077152	NA	1.03595748696426	NA	NA	1.23064778046072	1.20422913775524	1.16227446018315	0.798722145493281	0.839822703647764	NA	0.785782490199926	NA	NA	0.839822703647764	0.884873392684247	0.913580617246689	0.695326188486045	p.Ala192Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	-3.039	48.9	67.7	42.2	0.59	26.8	163.9	-83.3	138.3	35.5371900826446	-2	0	1	32.07	0	0	0	0	5	29.7903913680234	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-2.391	-3.949	1.558	12.05	12.05	77.42	0.003235306	0	0.092470428	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L193A	193	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.814	-3.115	1.301	12.003	12.003	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193C	193	L	C	missense	possibly_wt-like	0.824538421960646	0.163611753791461	6	0.0667942187851585	0.693624158766247	0.955452685155046	0.89176067824321	0.831406085957865	0.714787094646642	1.10245884825131	NA	0.776375342774014	NA	0.630442481890836	0.682741839339019	0.731391506324755	0.691487736845844	0.644620870143172	0.779182307767399	NA	0.673995941832195	NA	0.610808054414888	p.Leu193Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.814	-3.08	1.266	14.991	14.991	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L193D	193	L	D	missense	low	0.162667217720446	0.145597328304459	3	0.0840606566898698	-0.00208864190848473	0.327423077349377	NA	NA	NA	NA	-0.00442356852820527	0.230116528324415	0.262308693365128	NA	0.404759890527215	NA	NA	NA	NA	0.378476834990084	0.404759890527215	0.428865001412956	NA	p.Leu193Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.814	-4.262	2.448	2.583	NA	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193E	193	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.814	-3.404	1.59	8.477	8.477	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193F	193	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.814	-2.921	1.107	14.06	14.06	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193G	193	L	G	missense	low	0.487474709885751	0.213835171509049	7	0.0808220979102553	0.32906630882668	0.645883110944821	0.16571776800793	0.472013719813121	0.400137127008211	0.508105936839688	0.779334295606792	0.732016403124836	NA	0.354997718799676	0.518527922447227	0.385957337950332	0.525813904468139	0.490300018741343	0.518527922447227	0.671240044939578	0.652132631922488	NA	0.472466457350997	p.Leu193Gly	0	0	NA	NA	NA	NA	NA	NA	NA	7.101	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.814	-4.054	2.24	3.247	NA	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193H	193	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.814	-4.103	2.289	7.994	7.994	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193I	193	L	I	missense	wt-like	0.915779637384796	0.0967155756670787	6	0.0394839684273133	0.838392481300545	0.993166793469046	NA	0.759571693773024	1.02014126457914	0.992652935760169	0.948728649442339	NA	0.849365094548703	0.9242181862054	0.739782472112818	NA	0.658373290989772	0.79438257467076	0.731026755610817	0.734515243882491	NA	0.745049700343144	0.758356331090585	p.Leu193Ile	0	0	NA	NA	NA	NA	NA	NA	NA	2.928	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.814	-2.413	0.599	10.78	10.78	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L193K	193	L	K	missense	possibly_low	0.385375259833648	0.30882583821296	2	0.218372844406003	-0.0426276504036877	0.813378170070984	0.167002415427645	NA	NA	NA	0.603748104239651	NA	NA	NA	0.496110251741889	0.386568543027645	NA	NA	NA	0.605651960456133	NA	NA	NA	p.Leu193Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.814	-2.527	0.713	9.35	9.35	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193M	193	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.814	-2.682	0.868	6.31	6.31	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.635	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L193N	193	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.814	-3.751	1.937	8.802	8.802	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193P	193	L	P	missense	low	0.333540021506562	0.109698016849897	3	0.0633341795578564	0.20940731058277	0.457672732430353	0.31139260660357	0.452621941195074	NA	NA	NA	NA	NA	0.236605516721041	0.455266005542797	0.455266005542797	0.516874620880302	NA	NA	NA	NA	NA	0.413004203897121	p.Leu193Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.814	-3.376	1.562	14.732	14.732	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L193Q	193	L	Q	missense	low	0.334335804134771	0.276084010705217	7	0.104349947612471	0.129813665025686	0.538857943243855	0.389935372153901	0.357218553954827	0.360418654524336	0.561296945869473	-0.169589521655751	NA	0.162924914009802	0.678145710086806	0.47289526495948	0.492634809117938	0.47289526495948	0.47081999611145	0.541854921435571	0.316781103661946	NA	0.37533755449192	0.634766908087302	p.Leu193Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.814	-3.27	1.456	6.264	6.264	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L193R	193	L	R	missense	wt-like	0.939554700001176	0.24387439766822	6	0.0995613059359553	0.74441812611293	1.13469127388942	NA	1.09559835120677	0.972983270457152	0.751497342872348	1.24816848124064	NA	1.0004565676208	0.568624186609348	0.792264872610571	NA	0.813275924886281	0.771253820334862	0.625267598679281	0.846367348155486	NA	0.826426569461516	0.579759935724834	p.Leu193Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.814	-3.516	1.702	9.818	9.818	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L193S	193	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.814	-3.499	1.685	5.621	5.621	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193T	193	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.814	-3.061	1.247	7.506	7.506	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193V	193	L	V	missense	possibly_wt-like	0.772001822833617	0.164640540222084	5	0.0736294879577736	0.627690678236255	0.916312967430979	0.61095907882277	0.766516241320196	1.02121093197818	NA	0.638634432635125	NA	NA	0.822688429411817	0.661574610535346	0.597792698862294	0.661574610535346	0.794907195680497	NA	0.618683323778635	NA	NA	0.707363208016816	p.Leu193Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.814	-2.343	0.529	12.96	12.96	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.43	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L193W	193	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.814	-5.596	3.782	0.798	NA	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L193X	193	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L193Y	193	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu193Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	65.1	41.9	0.876	36.5	-115.8	-141.9	173.2	0.523560209424084	-6.5	0	1	31.84	0	0	0	0	8	30.3093744221157	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.814	-3.391	1.577	9.215	9.215	31.27	0.003285043	0	0.093892012	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194A	194	L	A	missense	possibly_wt-like	0.720671248921879	0.11368350317076	8	0.0401931880005432	0.641894048016966	0.799448449826791	0.928133940811601	0.786950247883896	0.575994076076917	0.731281778618289	0.682810889098805	0.690189978175899	0.59258406798097	0.777425012728652	0.633351215351781	0.748697050569109	0.670994343665893	0.576549492430773	0.616402031819304	0.635184901358051	0.631517529345512	0.606749136014718	0.684629744936071	p.Leu194Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.142	-3.093	0.951	8.266	8.266	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L194C	194	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.142	-3.749	1.607	19.668	19.668	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194D	194	L	D	missense	possibly_low	0.425230331505434	0.286553155038078	3	0.165441541198371	0.100970869209828	0.749489793801041	NA	NA	0.65000479862712	NA	0.102557482982706	NA	NA	0.523128712906476	0.556909922456836	NA	NA	0.612848233544697	NA	0.41843830456803	NA	NA	0.556909922456836	p.Leu194Asp	0	0	NA	NA	NA	NA	NA	NA	NA	6.105	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.142	-4.206	2.064	3.346	NA	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194E	194	L	E	missense	possibly_low	0.636594651729797	0.117778950589348	8	0.0416411473213815	0.554979502704963	0.718209800754631	0.558286617467593	0.728432141306833	0.707540245495705	0.71172176717249	0.738334434029674	0.38977652816593	0.644887398551577	0.613778081648573	0.621371661469912	0.572732378558962	0.644018481367793	0.641066635132926	0.60782395865373	0.655925045713318	0.48345194413187	0.634919364286094	0.602438391772714	p.Leu194Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.142	-2.927	0.785	10.983	10.983	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L194F	194	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.142	-2.953	0.811	28.024	28.024	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.8	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
L194G	194	L	G	missense	low	0.454462046566146	0.0613228496973036	8	0.0216809014313234	0.41196826060839	0.496955832523903	0.534484833501246	0.440682644441069	0.433294190687354	0.472912214721104	0.428601630243748	0.51088481750739	0.334401354342623	0.480434687084639	0.523418868476791	0.561408048640806	0.511370806009804	0.50656198226657	0.503093661371326	0.540228127044308	0.543142912478897	0.467693632291163	0.535466930943778	p.Leu194Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.142	-3.581	1.439	15.435	15.435	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194H	194	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.142	-3.888	1.746	14.407	14.407	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L194I	194	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.142	-2.55	0.408	10.848	10.848	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
L194K	194	L	K	missense	possibly_low	0.646789484775925	0.300628379749038	7	0.113626847123463	0.424084956737098	0.869494012814751	1.07066160278838	0.959634454211633	0.488586941275321	0.759890557154478	0.612725911052458	0.248885248648478	0.387141678300728	NA	0.609005510909786	0.816508365425615	0.750598856583945	0.533680447941701	0.628948455738386	0.609005510909786	0.414010480200884	0.496099222313781	NA	p.Leu194Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.142	-2.844	0.702	21.451	21.451	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.8	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L194L	194	L	L	synonymous	wt-like	1.23922998991713	0.240194956686147	6	0.0980591804451611	1.0470375278911	1.43142245194316	0.962666559714235	1.12223060421441	NA	NA	1.65945922740996	1.34454385136394	1.20405283182745	1.14242686497281	0.902016694097245	0.765126859777709	0.82555294531373	NA	NA	1	0.954030683024836	0.936082172179936	0.867951216014553	p.Leu194=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L194M	194	L	M	missense	wt-like	1.06501126019793	0.143789139004369	5	0.0643044578479871	0.938976838770498	1.19104568162536	NA	1.03537082754206	0.884821033483673	1.04170226794384	1.2855854975306	NA	1.07757667448946	NA	0.78551205007951	NA	0.78551205007951	0.728014434126276	0.752537415835119	0.86034401913648	NA	0.867962949479809	NA	p.Leu194Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.142	-3.325	1.183	6.712	6.712	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
L194N	194	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.142	-3.297	1.155	11.71	11.71	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194P	194	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.142	-3.169	1.027	14.732	14.732	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194Q	194	L	Q	missense	possibly_wt-like	0.826598535127474	0.218075113583618	4	0.109037556791809	0.612888850853287	1.04030821940166	1.10586799839205	0.81065004956428	0.572963644165367	0.8169124483882	NA	NA	NA	NA	0.667937523702394	0.833258741767524	0.68191955338334	0.575063209637815	0.653955494021448	NA	NA	NA	NA	p.Leu194Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.142	-3.053	0.911	10.139	10.139	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L194R	194	L	R	missense	possibly_low	0.69407294950915	0.190180660987432	8	0.0672390175173764	0.562286896819235	0.825859002199065	0.414226994907676	0.859282354989195	0.706235325544952	0.8929874939126	0.51705262354753	0.943417027162093	0.617060823271857	0.602320952737297	0.63017939431183	0.504192192829179	0.704338227723974	0.640426633929929	0.687318322483533	0.573267918933881	0.756326226155925	0.619932154693731	0.596684071038621	p.Leu194Arg	0	0	NA	NA	NA	NA	NA	NA	NA	3.604	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.142	-2.693	0.551	14.257	14.257	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L194S	194	L	S	missense	low	0.320948748248697	0.324853005811671	3	0.187553970352427	-0.046650278799554	0.688547775296948	NA	0.241754434449874	NA	NA	0.0430153225559303	NA	NA	0.678076487740286	0.419668249077905	NA	0.419668249077905	NA	NA	0.396197055310379	NA	NA	0.634732141298264	p.Leu194Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.142	-3.549	1.407	4.584	4.584	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.7	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L194T	194	L	T	missense	possibly_low	0.6724294488843	0.209394354713482	5	0.0936440022488099	0.488890577108445	0.855968320660155	NA	0.785009341162158	0.652118598881877	0.962754980495627	NA	0.432045493276249	NA	0.530218830605586	0.613884952084526	NA	0.670099618331776	0.613884952084526	0.717914961250627	NA	0.504285162668613	NA	0.560470920294872	p.Leu194Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.142	-2.835	0.693	10.251	10.251	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.7	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L194V	194	L	V	missense	possibly_low	0.689849347237721	0.0644146034010599	8	0.0227740014361658	0.645213124638973	0.73448556983647	0.815228996545063	0.621442226740679	0.700177024690229	0.711353212618751	0.619587636628527	0.725502645745108	0.648616989752478	0.676886045180934	0.635531170650486	0.694979529223941	0.594697931345873	0.637455325358166	0.607662328486169	0.611568624975199	0.648922178800842	0.636928097465073	0.6341342438359	p.Leu194Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.142	-2.475	0.333	12.292	12.292	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.15	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.642857142857143
L194W	194	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.142	-4.318	2.176	15.155	15.155	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.7	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L194X	194	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu194Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L194Y	194	L	Y	missense	possibly_wt-like	0.737919674610153	0.593414106946508	5	0.265382856387944	0.217778833975417	1.25806051524489	1.2666625854508	0.208837039509124	0.00915500299671634	NA	0.940964671268462	NA	NA	1.26397907382566	0.731615104341728	0.9097610306498	0.404493883995459	0.29854187329102	NA	0.731615104341728	NA	NA	0.929000576730778	p.Leu194Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.3	61.9	40	0.965	22.2	-142.4	-116.7	128.8	26.1780104712042	-3.9	0	1	29.29	0	0	0	0	9	31.5593690979398	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.142	-2.824	0.682	12.444	12.444	77.42	0.003207746	0	0.091682716	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.15	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F195A	195	F	A	missense	low	0.241853673573286	0.164965618392877	8	0.0583241537141178	0.127540432864838	0.356166914281735	0.173561593781945	0.28080858064185	0.41218018121017	0.545303874774406	0.100397828514286	0.0553413518012715	0.154967004682185	0.212268973180177	0.409206407059974	0.389689246071634	0.43767155320835	0.496206564328725	0.534841135458203	0.417631591929485	0.318617979131909	0.371051477106863	0.400781222190463	p.Phe195Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.412	-3.568	1.156	3.459	NA	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F195C	195	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.412	-5.282	2.87	1.228	NA	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F195D	195	F	D	missense	possibly_wt-like	0.906214257306275	0.425263702723053	2	0.300706847987971	0.316839665345292	1.49558884926726	NA	NA	0.605507409318305	NA	1.20692110529425	NA	NA	NA	0.71099213617007	NA	NA	0.591024379390718	NA	0.830959892949422	NA	NA	NA	p.Phe195Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.412	-3.621	1.209	10.14	10.14	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195E	195	F	E	missense	low	0.0323972395850511	0.157805552084397	2	0.111585375987764	-0.186306078552327	0.251100557722429	NA	NA	NA	NA	NA	-0.079188136402713	NA	0.143982615572815	0.309398300081806	NA	NA	NA	NA	NA	0.252312068398706	NA	0.366484531764906	p.Phe195Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.412	-3.335	0.923	8.845	8.845	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195G	195	F	G	missense	low	0.282181707938156	0.157810966639591	8	0.0557946023282294	0.172826296843091	0.39153711903322	0.203831271002046	0.188850289710845	0.326903048249673	0.456561893617754	0.572531414093231	0.128898287159913	0.156354333603592	0.223523126068191	0.405262223168839	0.404090847726416	0.395280328706637	0.454382184487398	0.49592320285223	0.593991345833336	0.354872183729066	0.371798683297695	0.406433598611262	p.Phe195Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.412	-3.493	1.081	14.043	14.043	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195H	195	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.412	-3.734	1.322	10.718	10.718	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195I	195	F	I	missense	possibly_wt-like	0.765954775727883	0.123443342732834	4	0.0617216713664169	0.644982522784088	0.886927028671677	NA	0.602507336359691	0.784516187401132	0.774526024900987	NA	NA	NA	0.902269554249721	0.657093269027939	NA	0.585969265546092	0.678819675380982	0.635366862674897	NA	NA	NA	0.747332673337792	p.Phe195Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.412	-2.081	-0.331	12.263	12.263	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.83	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
F195K	195	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.412	-2.564	0.152	8.732	8.732	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195L	195	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.412	-1.801	-0.611	29.072	29.072	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	neutral	neutral	neutral	0.79	Neutral	TOLERATED	neutral	TOLERATED	null	D	D	T	T	D	B	0.214285714285714
F195M	195	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.412	-3.285	0.873	7.114	7.114	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.83	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
F195N	195	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.412	-4.301	1.889	1.773	NA	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195P	195	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.412	-3.724	1.312	10.312	10.312	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195Q	195	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.412	-3.53	1.118	6.37	6.37	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195R	195	F	R	missense	low	0.210735036094635	0.150165258358555	8	0.053091436241982	0.106677733172846	0.314792339016425	0.22186955638455	0.195688867947847	0.329714550243788	0.349053304320841	-0.11185510634599	0.31679969432962	0.128213621862284	0.256395800014144	0.417808437789891	0.4126730403519	0.398432798183639	0.455761092563271	0.448775145323126	0.338347091735696	0.447483655732488	0.356642281882656	0.422943835227881	p.Phe195Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.412	-3.146	0.734	9.903	9.903	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195S	195	F	S	missense	low	0.282535158989208	0.124936198447152	7	0.0472214444058539	0.189982828655774	0.375087489322642	0.15800289182821	0.33893097698902	0.306283963287889	0.509701519709674	0.183003579584344	0.309560731074774	NA	0.172262450450544	0.444269503496801	0.382286781018112	0.464464999750098	0.444269503496801	0.519227667773982	0.448487964733157	0.44391576844038	NA	0.380688023883554	p.Phe195Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.412	-3.297	0.885	5.348	5.348	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F195T	195	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.412	-3.132	0.72	7.261	7.261	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F195V	195	F	V	missense	low	0.501018148584295	0.279292281663999	8	0.0987447331488384	0.307482027949553	0.694554269219037	0.998059473981174	0.643335797476244	0.479571009039857	0.547185533426868	0.575005048278225	0.385293053256869	0.0115039844066333	0.368191288808489	0.53246245076842	0.781965977319929	0.604790498995829	0.529258561776574	0.535666339760265	0.594915341773127	0.481242161792968	0.293783242262667	0.479092902252364	p.Phe195Val	1	0	NA	NA	NA	NA	NA	NA	NA	8.342	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.412	-2.541	0.129	11.223	11.223	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
F195W	195	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.412	-5.507	3.095	0.73	NA	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F195X	195	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe195Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F195Y	195	F	Y	missense	possibly_low	0.542573969314727	0.631156428701995	5	0.282261735802732	-0.0106488670723879	1.09579680570184	0.333125142041076	0.144926213495449	0.203815829484281	0.371543434142868	1.65945922740996	NA	NA	NA	0.458638226418511	0.465605835599246	0.375032068794171	0.394013754961971	0.458638226418511	1	NA	NA	NA	p.Phe195Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	3.239	42.3	62	37.7	0.84	25.7	171.7	-95.2	111.4	0.43859649122807	-6.8	0	1	25.23	0	0	0	0	6	29.5781669117611	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.412	-3.136	0.724	8.427	8.427	77.42	0.003276442	0	0.093646172	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H196A	196	H	A	missense	low	0.413465695310599	0.10139426854003	8	0.0358482874290526	0.343204343042216	0.483727047578982	0.298061214197763	0.42949895792013	0.521405379085475	0.51943243510184	0.261008254614193	0.51370386994167	0.39409326354895	0.37052218807477	0.503029307469367	0.448923242072411	0.506215314740163	0.549776331575672	0.523495175716567	0.477625661588052	0.544532346435386	0.499843300198572	0.480263591879836	p.His196Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.637	-3.091	0.454	8.194	8.194	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H196C	196	H	C	missense	possibly_low	0.670706622934395	0.0938256145088086	5	0.0419600904144773	0.588466356933976	0.752946888934815	0.739747437553518	0.583805643146073	0.553872512076543	0.7287509139856	NA	0.747356607910243	NA	NA	0.615292117234053	0.659067175848849	0.577348099715863	0.565699916896093	0.615292117234053	NA	0.65969339991997	NA	NA	p.His196Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.637	-3.403	0.766	19.428	19.428	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H196D	196	H	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.637	-3.196	0.559	13.782	13.782	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H196E	196	H	E	missense	possibly_wt-like	0.845577369503127	0.229461153701732	6	0.0936771237265978	0.661973580823693	1.02918115818256	NA	0.935601069052725	0.514928182646882	0.756369382780599	1.21577768432334	NA	0.827378279669931	0.823409618545286	0.720466585488294	NA	0.739519870496962	0.546599574633338	0.627404239289865	0.834268160240099	NA	0.733207747118782	0.707725423857806	p.His196Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.637	-2.881	0.244	10.762	10.762	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H196F	196	H	F	missense	low	0.283027049201035	0.115613311280064	6	0.0471989366849526	0.190518833189942	0.375535265212129	NA	0.227970748120641	0.337324477677395	0.46648295436092	0.161454352971108	NA	0.325089600815901	0.179840161260248	0.449965956824209	NA	0.413314201653491	0.459493400211272	0.500274099331549	0.440438513437146	NA	0.462678383365467	0.384493914413975	p.His196Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.637	-3.923	1.286	10.617	10.617	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H196G	196	H	G	missense	low	0.331243001093774	0.129241514535403	8	0.0456937756694015	0.241684846464095	0.420801155723454	0.309931119478671	0.37811216434052	0.325714138955089	0.586811539348289	0.25267863895985	0.329297433676414	0.124793095500477	0.342605878490886	0.460406671959917	0.454570664286154	0.482526867717036	0.453799080996377	0.553044385728964	0.474514235051615	0.453643450143055	0.354800008983987	0.466242679633679	p.His196Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.637	-3.521	0.884	12.652	12.652	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H196H	196	H	H	synonymous	possibly_wt-like	0.772200597262951	0.137727107865873	2	0.0973877719251699	0.581324071755017	0.963077122770885	NA	NA	NA	NA	0.674812825337781	NA	NA	0.86958836918812	0.681557966818428	NA	NA	NA	NA	0.632197321995587	NA	NA	0.730918611641269	p.His196=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	0	-3.2	-3.2	0	216	216	0	10.4	10.4	0	155	155	0	7.59	7.59	0	NA	NA	NA	NA	NA	NA	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
H196I	196	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.637	-2.611	-0.026	9.163	9.163	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.135	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H196K	196	H	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.637	-2.272	-0.365	15.126	15.126	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.51	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H196L	196	H	L	missense	low	0.311193115409936	0.0759881070590978	8	0.0268658528955087	0.258537011320788	0.363849219499085	0.446951935210615	0.281891408918005	0.405157913607186	0.282258330706053	0.244362729208215	0.234644891036413	0.277868165028145	0.316409549564859	0.445628171575542	0.519761951006399	0.438170718820135	0.492762475891668	0.419482106699509	0.471407928188301	0.406991796838298	0.437245230047488	0.45308562433095	p.His196Leu	1	0	NA	NA	NA	NA	NA	NA	NA	0.37	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.637	-2.942	0.305	12.579	12.579	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.935	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.785714285714286
H196M	196	H	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.637	-3.899	1.262	6.873	6.873	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H196N	196	H	N	missense	low	0.546224093799526	0.162420515551643	6	0.0663078978102175	0.416263002200937	0.676185185398115	0.424203975610637	0.78496364333415	0.318634502928192	NA	0.534583352330581	NA	0.590455319801884	0.624503768791712	0.592709457795223	0.508939005976763	0.670078552402139	0.450326856074551	NA	0.579816309280106	NA	0.60560260631034	0.607825347299977	p.His196Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.637	-2.965	0.328	14.461	14.461	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.935	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
H196P	196	H	P	missense	low	0.309044602132383	0.16120011946505	8	0.0569928488009094	0.197340671106264	0.420748533158502	0.33252287755443	0.224065723903087	0.451689200339361	0.502229604008212	0.113077076424235	0.0936414788200295	0.48307798715813	0.272052868851582	0.448063429963809	0.465319292298357	0.411514051209034	0.515583860045069	0.51595084762734	0.42236777064963	0.337495065762355	0.547769884402457	0.430807567629262	p.His196Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.637	-3.618	0.981	13.627	13.627	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H196Q	196	H	Q	missense	possibly_low	0.617428178863164	0.302070509547136	8	0.106798052848628	0.408107841660849	0.82674851606548	0.397437582991552	0.577624513602266	0.553811808724023	0.983884606408702	0.892233111574179	0.0529912670537874	0.626924416074569	0.854518124476235	0.599871661814632	0.496204184874026	0.574498703021852	0.565670144787377	0.727181391259924	0.713412023396966	0.317459686540728	0.625244620607411	0.723349610516728	p.His196Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.637	-3.037	0.4	11.732	11.732	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.135	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
H196R	196	H	R	missense	possibly_low	0.64343456565424	0.122149223913787	8	0.0431862722730563	0.558791027372509	0.728078103935971	0.882238899004491	0.507432854822779	0.707298925287093	0.617872297142841	0.553814960357136	0.58012562130449	0.571637501862537	0.727055465452551	0.591233748131815	0.726861267345207	0.54214152961917	0.640948279042401	0.566666128930809	0.587000042363995	0.577269813702995	0.595467453899635	0.659331737686412	p.His196Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.637	-2.528	-0.109	17.501	17.501	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.51	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
H196S	196	H	S	missense	low	0.366812149221849	0.248039743134543	8	0.0876952921871023	0.194932534921412	0.538691763522286	0.552068046354557	0.397204575490125	0.537573018982507	0.557963099648125	-0.125146053452618	0.254964106912431	0.186483261358647	0.57338713848102	0.515860502988599	0.569773728442521	0.491328147940144	0.557705790373314	0.540392858037053	0.333382420226466	0.417006583425467	0.388025924721374	0.582152119047802	p.His196Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.637	-2.817	0.18	8.95	8.95	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
H196T	196	H	T	missense	possibly_wt-like	0.739949989125352	0.349882038584454	5	0.156472004476209	0.433270495763193	1.04662948248751	NA	0.431141387102935	0.553135604147613	0.786459825058004	1.32255189733992	NA	0.606461231978288	NA	0.614223284855699	NA	0.506972446952077	0.565338498587835	0.640600449126208	0.874152367816204	NA	0.614223284855699	NA	p.His196Thr	0	0	NA	NA	NA	NA	NA	NA	NA	0.897	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.637	-2.717	0.08	12.265	12.265	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.935	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H196V	196	H	V	missense	possibly_low	0.574837635440333	0.180827366689927	7	0.0683463203566044	0.440881309065551	0.708793961815114	0.429577984546379	0.298709820146774	0.654129237874153	0.576452259596171	0.575918281349295	NA	0.612331714227537	0.87674415034202	0.595256468870605	0.511495833240531	0.445923723350154	0.614871074929154	0.548501307627883	0.595256468870605	NA	0.617385087808213	0.734512588821887	p.His196Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.637	-2.814	0.177	8.284	8.284	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H196W	196	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.637	-5.769	3.132	2.128	NA	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H196X	196	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His196Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H196Y	196	H	Y	missense	possibly_wt-like	0.769518907618666	0.273798931014466	3	0.158077886525034	0.45969194327739	1.07934587195994	NA	NA	NA	NA	1.08566634763964	0.60945728650317	NA	0.613433088713189	0.602265119741251	NA	NA	NA	NA	0.785666654186467	0.591726590431164	NA	0.602265119741251	p.His196Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.6	58.6	38	0.833	51.2	-39.5	-88.4	-41.2	23.1481481481481	-4.9	0	1	28.23	0	0	0	0	7	32.3642657549959	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.637	-3.519	0.882	24.573	24.573	77.42	0.00322604	0	0.092205609	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.585	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
K197A	197	K	A	missense	possibly_wt-like	0.717005485609549	0.487761261645739	6	0.19912770122137	0.326722362891411	1.10728860832769	NA	1.08665820546429	0.952548603303309	1.02008725398405	0.0390906159443661	NA	0.143855273420238	1.05979296154104	0.752144852831059	NA	0.809154668157708	0.761231587512268	0.743058118149849	0.394731028928647	NA	0.365066772065629	0.826448498576463	p.Lys197Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.21	-2.825	0.615	14.807	14.807	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K197C	197	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.21	-3.952	1.742	17.989	17.989	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197D	197	K	D	missense	low	0.240237509354568	0.268837477420872	3	0.1552133899572	-0.0639751448799153	0.544450163589052	0.0145719998002891	0.537677678972563	NA	NA	NA	NA	NA	0.168462849290853	0.378779681583855	0.314045730512142	0.556083884545169	NA	NA	NA	NA	NA	0.378779681583855	p.Lys197Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.21	-3.991	1.781	4.088	NA	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K197E	197	K	E	missense	low	0.593203388136087	0.150611637514835	8	0.0532492551061749	0.488836765924399	0.697570010347775	0.854582930460527	0.524715290327835	0.666522009191439	0.501936061523711	0.355506327218422	0.692317217619201	0.524588642357698	0.625458626389863	0.589216085850366	0.71370320690567	0.550108441531233	0.620949140136869	0.515822114118353	0.512924266342963	0.632565987572171	0.570127249027404	0.608304922673327	p.Lys197Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.21	-2.541	0.331	13.416	13.416	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.07	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
K197F	197	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.21	-3.357	1.147	11.286	11.286	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197G	197	K	G	missense	wt-like	0.90008210704297	0.225557220234926	8	0.0797465199868518	0.743781799976337	1.0563824141096	0.74381590488204	0.998441388935646	1.05400504088697	1.04988802271602	1.05386503112078	0.934996613157742	0.962673203321634	0.402971651322924	0.762307745797258	0.661002857071507	0.768488200388119	0.81099114714489	0.756127291206398	0.77378765949854	0.752176034054825	0.8060766990889	0.496561271745798	p.Lys197Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.21	-2.596	0.386	22.393	22.393	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K197H	197	K	H	missense	possibly_wt-like	0.709528046532707	0.331800546791171	4	0.165900273395586	0.384369485652011	1.0346866074134	NA	0.582061820302194	NA	NA	0.302814589779996	NA	0.922132261646609	1.03110351440203	0.680392921246936	NA	0.576544226732604	NA	NA	0.493241909206662	NA	0.784241615761267	0.812039279495476	p.Lys197His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.21	-3.629	1.419	8.961	8.961	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.415	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K197I	197	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.21	-2.898	0.688	7.748	7.748	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197L	197	K	L	missense	wt-like	0.982909082860863	0.175122876874208	5	0.0783173314212111	0.829409933910002	1.13640823181172	NA	0.795213178673883	0.969246612648045	0.95099426305633	NA	1.27134341741555	NA	0.927747942510506	0.760129144336387	NA	0.674803415698596	0.769421167311483	0.712757280491929	NA	0.91795218823673	NA	0.760129144336387	p.Lys197Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.21	-3.149	0.939	11.834	11.834	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197M	197	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.21	-4.116	1.906	4.381	4.381	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K197N	197	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.21	-2.914	0.704	11.474	11.474	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.76	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K197P	197	K	P	missense	low	0.560821946917322	0.0501386702339488	2	0.0354533937221013	0.491334572092285	0.630309321742359	NA	NA	NA	NA	0.596275340639424	NA	0.525368553195221	NA	0.586703952213059	NA	NA	NA	NA	0.602860600574582	NA	0.570547303851536	NA	p.Lys197Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.21	-3.396	1.186	14.118	14.118	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197Q	197	K	Q	missense	possibly_low	0.449465826870284	0.739613680872229	2	0.522985849203096	-0.57556760199188	1.47449925573245	NA	NA	NA	NA	-0.0735200223328121	NA	NA	0.97245167607338	0.567624101698539	NA	NA	NA	NA	0.352666695739629	NA	NA	0.78258150765745	p.Lys197Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.21	-2.774	0.564	8.334	8.334	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.07	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K197R	197	K	R	missense	possibly_wt-like	0.933505911923413	0.343974939450448	6	0.140427180993056	0.658273694726535	1.20873812912029	1.11694117098631	0.251516143096606	NA	NA	1.19395185643945	0.969516471965326	0.994029592231015	1.07508023682177	0.824540215443328	0.838527097277153	0.424168232478797	NA	NA	0.82611538790633	0.769189929723171	0.822965042980325	0.834126502882508	p.Lys197Arg	1	0	NA	NA	NA	NA	NA	NA	NA	-0.676	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.21	-2.542	0.332	17.672	17.672	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	1.96	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K197S	197	K	S	missense	possibly_low	0.36274974257849	0.53217594652423	5	0.237996318483694	-0.103714470102675	0.829213955259656	NA	NA	0.941105180459407	NA	-0.330376891104431	0.0647570343729513	0.300860623630372	0.837402765534154	0.449628816336902	NA	NA	0.755619132600938	NA	0.256720938969266	0.323258711929044	0.449628816336902	0.714753454743799	p.Lys197Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.21	-2.466	0.256	17.026	17.026	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.615	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K197T	197	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.21	-3.105	0.895	13.424	13.424	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.415	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
K197V	197	K	V	missense	low	0.501884251334809	0.0669305282903499	2	0.0473270304225045	0.409124976211469	0.594643526458149	NA	NA	NA	NA	0.549211281757314	NA	NA	0.454557220912305	0.553875209050142	NA	NA	NA	NA	0.585280394260754	NA	NA	0.52247002383953	p.Lys197Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.21	-2.98	0.77	8.15	8.15	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197W	197	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.21	-5.736	3.526	0.655	NA	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K197X	197	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys197Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K197Y	197	K	Y	missense	possibly_wt-like	0.7655324280116	0.171216093763588	4	0.0856080468817939	0.597743739336467	0.933321116686732	NA	0.979512761014887	0.592326566074557	0.820397169276657	0.669893215680298	NA	NA	NA	0.642921692714573	NA	0.759762421477109	0.584559802366174	0.655483723737755	0.63035966169139	NA	NA	NA	p.Lys197Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.2	58.9	36.1	0.976	41.4	-127.5	-176.8	170.5	12.6086956521739	-3.7	0	1	25.39	0	0	0	0	7	30.957970183137	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.21	-3.671	1.461	7.561	7.561	77.42	0.002930658	0	0.083763098	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M198A	198	M	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.611	-3.54	0.929	4.193	NA	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M198C	198	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.611	-3.555	0.944	14.631	14.631	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198D	198	M	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.611	-4.222	1.611	2.628	NA	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M198E	198	M	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.611	-3.367	0.756	8.624	8.624	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M198F	198	M	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.611	-2.517	-0.094	16.069	16.069	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
M198G	198	M	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.611	-4.035	1.424	1.929	NA	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M198H	198	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.611	-4.05	1.439	10.015	10.015	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198I	198	M	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.611	-1.896	-0.715	24.256	24.256	90.57	0.003217053	0	0.091948724	4.071e-06	1	245612	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	neutral	neutral	neutral	0.325	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M198K	198	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.611	-2.78	0.169	10.107	10.107	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	2	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.785714285714286
M198L	198	M	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.611	-2.204	-0.407	34.011	34.011	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
M198N	198	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.611	-3.484	0.873	9.274	9.274	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198P	198	M	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.611	-3.729	1.118	10.189	10.189	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198Q	198	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.611	-3.764	1.153	4.831	4.831	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198R	198	M	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.611	-3.167	0.556	10.415	10.415	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.857142857142857
M198S	198	M	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.611	-3.295	0.684	6.33	6.33	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M198T	198	M	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.611	-2.867	0.256	7.444	7.444	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.714285714285714
M198V	198	M	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.611	-2.192	-0.419	15.747	12.96	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.357142857142857
M198W	198	M	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.611	-5.589	2.978	0.747	NA	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M198X	198	M	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M198Y	198	M	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met198Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	60.9	35.3	0.963	18	-155.6	-133.3	148.4	0	-6.6	0	1	24.96	0	0	0	0	7	28.7507909084255	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.611	-4.339	1.728	3.727	NA	90.57	0.003217053	0	0.091948724	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M199A	199	M	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-3.101	-3.13	0.029	26.235	26.235	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M199C	199	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-3.101	-5.368	2.267	1.941	NA	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
M199D	199	M	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-3.101	-3.439	0.338	20.279	20.279	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
M199E	199	M	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-3.101	-2.96	-0.141	26.536	26.536	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.83	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M199F	199	M	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-3.101	-3.424	0.323	14.156	14.156	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M199G	199	M	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-3.101	-3.499	0.398	15.055	15.055	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
M199H	199	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-3.101	-3.82	0.719	19.327	19.327	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M199I	199	M	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-3.101	-2.426	-0.675	19.607	19.607	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
M199K	199	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-3.101	-2.453	-0.648	11.55	11.55	42.43	0.003240687	0	0.092624222	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Mar 3, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
M199L	199	M	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-3.101	-2.7	-0.401	31.402	31.402	42.43	0.003240687	0	0.092624222	4.071e-06	1	245646	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.485	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M199N	199	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-3.101	-3.672	0.571	7.781	7.781	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
M199P	199	M	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-3.101	-3.554	0.453	14.24	14.24	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
M199Q	199	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-3.101	-3.114	0.013	10.67	10.67	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
M199R	199	M	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-3.101	-2.456	-0.645	29.453	29.453	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.357142857142857
M199S	199	M	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-3.101	-2.822	-0.279	9.113	9.113	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M199T	199	M	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-3.101	-2.526	-0.575	9.153	9.153	42.43	0.003240687	0	0.092624222	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Nov 26, 2013)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.357142857142857
M199V	199	M	V	missense	wt-like	1.25791496932706	0.231639075379164	3	0.133736882524996	0.995795496173402	1.52003444248071	NA	1.50065451613158	NA	NA	1.23383237676259	NA	1.039258015087	NA	0.847324772701313	NA	1	NA	NA	0.841012270832216	NA	0.847324772701313	NA	p.Met199Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-3.101	-2.412	-0.689	24.184	24.184	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.025	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	T	B	0.214285714285714
M199W	199	M	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-3.101	-5.648	2.547	0.996	NA	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M199X	199	M	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M199Y	199	M	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met199Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	59.9	35.6	0.988	9.4	-143.7	-132.8	129.4	6.89655172413793	-5.2	0	1	26.9	0	0	0	0	7	30.1439326873585	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-3.101	-2.987	-0.114	11.499	11.499	42.43	0.003240687	0	0.092624222	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
F200A	200	F	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.142	-3.091	0.949	7.835	7.835	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200C	200	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.142	-5.237	3.095	1.228	NA	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F200D	200	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.142	-4.312	2.17	2.493	NA	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200E	200	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.142	-3.617	1.475	8.182	8.182	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200G	200	F	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.142	-3.509	1.367	14.296	14.296	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200H	200	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.142	-5.086	2.944	1.38	NA	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200I	200	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.142	-1.982	-0.16	14.89	14.89	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.83	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
F200K	200	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.142	-4.12	1.978	3.656	NA	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200L	200	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.142	-1.983	-0.159	29.072	29.072	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	neutral	neutral	neutral	0.565	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
F200M	200	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.142	-2.748	0.606	6.712	6.712	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.285	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F200N	200	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.142	-4.43	2.288	1.76	NA	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200P	200	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.142	-3.347	1.205	20.501	20.501	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200Q	200	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.142	-3.816	1.674	5.468	5.468	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200R	200	F	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.142	-3.55	1.408	10.415	10.415	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200S	200	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.142	-3.061	0.919	7.04	7.04	77.42	0.003588203	0	0.102556811	0	NA	NA	not provided	Likely pathogenic(Last reviewed: Sep 18, 2015)	criteria provided, single submitter	0	1	0	0	0	0	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.928571428571429
F200T	200	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.142	-3.292	1.15	7.567	7.567	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F200V	200	F	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.142	-2.335	0.193	9.754	9.754	77.42	0.003588203	0	0.102556811	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: May 9, 2013)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.635	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
F200W	200	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.142	-4.125	1.983	12.937	12.937	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F200X	200	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F200Y	200	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe200Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.3	61.2	33.7	0.76	8.5	-156.7	-86.9	133.6	0	-4.8	0	1	25.05	0	0	0	0	8	28.9838340779822	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.142	-2.762	0.62	9.294	9.294	77.42	0.003588203	0	0.102556811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.635	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E201A	201	E	A	missense	possibly_wt-like	0.738612777830201	0.109665209444693	3	0.0633152381936303	0.614517191298111	0.862708364362291	NA	0.670901381880774	0.679797912482556	0.865139039127274	NA	NA	NA	NA	0.627460339595716	NA	0.617497769489689	0.627460339595716	0.675105339717207	NA	NA	NA	NA	p.Glu201Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.309	-3.034	0.725	10.206	10.206	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.685	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
E201C	201	E	C	missense	possibly_wt-like	0.9150351656355	0.28494917588711	5	0.127433145483225	0.665270790051727	1.16479954121927	NA	0.480291869328433	NA	0.813351997348056	1.21984138156992	1.0842874638132	0.977403116117891	NA	0.814010132798783	NA	0.529629992077093	NA	0.652394052730402	0.835786104881695	0.825757417207308	0.814010132798783	NA	p.Glu201Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.309	-4.047	1.738	19.668	19.668	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E201D	201	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.309	-2.945	0.636	21.657	21.657	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
E201E	201	E	E	synonymous	wt-like	0.953640884923453	0.212548140703345	8	0.0751471158099637	0.806355244393864	1.10092652545304	1.05001702265794	0.800543448970361	0.617063880826205	0.747198352645701	1.10591706759221	1.25643441946408	0.992283902123358	1.05966898510776	0.799958611541571	0.80668615895784	0.677260580599174	0.59669227929767	0.623382269889753	0.793231064125302	0.910603950311433	0.822024825822311	0.826386231653736	p.Glu201=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E201F	201	E	F	missense	wt-like	0.925526886649127	0.114816103809883	3	0.0662891084419398	0.795602621535655	1.0554511517626	NA	1.02610801475519	0.800434483074825	0.95003816211737	NA	NA	NA	NA	0.712337980951599	NA	0.781242049273815	0.686626842690318	0.712337980951599	NA	NA	NA	NA	p.Glu201Phe	0	0	NA	NA	NA	NA	NA	NA	NA	-2.964	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.309	-3.928	1.619	19.703	19.703	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E201G	201	E	G	missense	possibly_low	0.641937182741537	0.169079706377084	8	0.0597787034701334	0.524773076897576	0.759101288585498	0.853823886776768	0.517529539240432	0.562628984323191	0.538671924048089	0.86456127442973	0.785698671780419	0.595062597850666	0.417520583483001	0.58903930304872	0.713342071744149	0.546795931212962	0.569994550270828	0.531932683245971	0.703075545463759	0.678591156079183	0.608084055826613	0.503868444654122	p.Glu201Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.309	-3.01	0.701	20.495	20.495	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.685	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
E201H	201	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.309	-2.458	0.149	13.09	13.09	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.135	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E201I	201	E	I	missense	possibly_low	0.671157401966784	0.613994114246909	4	0.306997057123454	0.0694542266450284	1.27286057728854	NA	-0.118912148836451	0.558439218090142	1.33056351168977	NA	NA	NA	0.914539026923671	0.660717330626749	NA	0.253407024042444	0.567939669105221	0.879217959474742	NA	NA	NA	0.753494992148277	p.Glu201Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.309	-2.977	0.668	11.319	11.319	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.88	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E201K	201	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.309	-2.869	0.56	21.451	21.451	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	1.995	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
E201L	201	E	L	missense	possibly_wt-like	0.741519414733921	0.0805026700289913	8	0.0284619919405614	0.685734935602152	0.797303893865691	0.787105358657042	0.631653953130924	0.827170535145279	0.696288566039194	0.703203973285861	0.681438158432392	0.870776781259311	0.734517991921368	0.652941133414598	0.68159896269191	0.599405365352925	0.699739605261383	0.601055704510972	0.642802489723766	0.627203996406279	0.756581893336069	0.663079777105429	p.Glu201Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.309	-3.004	0.695	13.418	13.418	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.34	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E201M	201	E	M	missense	wt-like	1.0056590726071	0.148531946018786	7	0.0561397987020254	0.8956270890518	1.1156910561624	NA	0.946193968485938	1.14974266404284	1.26718203465452	0.874499520616946	0.865661899369906	0.973937468813512	0.962395952266026	0.777531039913823	NA	0.744403018861847	0.857945900159765	0.851421915036984	0.70678785635489	0.718002847160978	0.812143558058564	0.777531039913823	p.Glu201Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.309	-3.585	1.276	6.712	6.712	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.34	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E201N	201	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.309	-2.998	0.689	12.339	12.339	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.685	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
E201P	201	E	P	missense	possibly_low	0.556646691667412	0.228442069346883	6	0.0932610842808923	0.373858325317709	0.739435058017116	0.478750441102043	0.516089002277012	0.357374347427589	0.576891596127728	0.995946527180611	NA	NA	0.414828235889491	0.540511400680393	0.534890933444359	0.546131867916427	0.469326908199747	0.548693979340906	0.752152907357697	NA	NA	0.502516218306605	p.Glu201Pro	0	0	NA	NA	NA	NA	NA	NA	NA	8.519	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.309	-3.487	1.178	35.969	35.969	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.995	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E201Q	201	E	Q	missense	possibly_wt-like	0.827648436835876	0.138369024721704	3	0.0798873936705816	0.671072022422763	0.984224851248989	NA	NA	NA	NA	0.928877256057732	0.669980154704394	NA	0.884087899745502	0.727099997522365	NA	NA	NA	NA	0.727099997522365	0.621556659287019	NA	0.738200972690628	p.Glu201Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.309	-3.209	0.9	18.898	18.898	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
E201R	201	E	R	missense	low	0.31747768190335	0.204122671291035	4	0.102061335645517	0.117441139824082	0.517514223982617	0.469041265560392	NA	0.288563275600374	0.0397400371629979	NA	NA	NA	0.472566149289634	0.482924942145175	0.530271535704155	NA	0.435578348586194	0.313125335295417	NA	NA	NA	0.531514973125076	p.Glu201Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.309	-2.843	0.534	13.488	13.488	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E201S	201	E	S	missense	possibly_wt-like	0.708393558393582	0.206052671419772	8	0.0728506206212621	0.565608965724517	0.851178151062647	1.15035795158872	0.781081529392198	0.578812455505293	0.561717817510322	0.54559492161392	0.692103566943368	0.556765916388177	0.800714308206658	0.609959200605115	0.854426016823661	0.668288963209165	0.577931773561214	0.542039495342316	0.583929546948898	0.632460684988857	0.587457716221373	0.696326748337998	p.Glu201Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.309	-2.74	0.431	8.022	8.022	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E201T	201	E	T	missense	wt-like	1.04106502170162	0.09389762470395	3	0.054211818899092	0.934811809122995	1.14731823428025	NA	NA	NA	NA	1.14946257523292	0.988925787692527	0.984806702179422	NA	0.809496958452046	NA	NA	NA	NA	0.809496958452046	0.778756251376375	0.817997655335203	NA	p.Glu201Thr	0	0	NA	NA	NA	NA	NA	NA	NA	0.595	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.309	-2.947	0.638	6.895	6.895	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.685	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E201V	201	E	V	missense	wt-like	1.01947987911686	0.0966965712920222	8	0.0341874006390387	0.952473805139307	1.08648595309442	1.11166131121444	1.12192936829526	1.04832230325489	0.981394957469428	0.834125513357096	0.964203534587165	0.995923111747871	1.09827893300877	0.81609445728092	0.836015063974827	0.825414080624667	0.808204034480431	0.726089551880542	0.691706637390709	0.766571327985883	0.823984880081409	0.845778002966565	p.Glu201Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.309	-2.873	0.564	8.885	8.885	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.34	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E201W	201	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.309	-4.083	1.774	14.169	14.169	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E201X	201	E	X	nonsense	low	0.0483942183878621	0.0536518349898071	4	0.0268259174949036	-0.00418361375439184	0.100972050530116	NA	-0.0109661235086419	0.0169812207040499	0.0953982920369455	NA	NA	NA	0.0921634843190949	0.32035133689291	NA	0.303168325034564	0.30238026103635	0.337534348751255	NA	NA	NA	0.340458473779078	p.Glu201Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	5	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E201Y	201	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu201Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	61.4	36	0.986	77.5	8.3	-73.9	-61.8	25.2336448598131	-3.7	0	0	35.57	0	0	0	0	6	30.543635963323	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.309	-3.097	0.788	15.279	15.279	77.42	0.002985203	0	0.085322077	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.34	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202A	202	T	A	missense	low	0.278806662631726	0.156652789868355	5	0.0700572574021262	0.141496961267907	0.416116363995546	NA	0.289530471803636	0.22702578538586	0.300443419010949	0.0709077613572973	NA	0.506125875600889	NA	0.427457205202599	NA	0.441692198248351	0.405397134984582	0.427457205202599	0.40661593630728	NA	0.560183324837751	NA	p.Thr202Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.242	-2.94	0.698	11.644	11.644	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.985	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
T202C	202	T	C	missense	wt-like	0.953408728112077	0.174573963635447	6	0.0712695222136719	0.813723031377903	1.09309442484625	1.24603373976423	1.04272007070392	0.950374861335179	0.872045378315087	0.741867898829137	NA	0.867410419724916	NA	0.757467131833545	0.899946310260951	0.788899927492605	0.760165470411518	0.678134125412117	0.657244928478484	NA	0.754768793255571	NA	p.Thr202Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.242	-5.426	3.184	0.861	NA	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202D	202	T	D	missense	possibly_wt-like	0.783696658564869	0.326700695661686	8	0.11550613866037	0.557308786797254	1.01008453033248	1.17891803660965	0.81442800545881	1.00815874203202	0.696364472156654	0.144963337951524	0.943717017403153	0.523758492209897	0.959265164697252	0.720067605311196	0.868014234653252	0.683661127469387	0.788505716982544	0.601088993255772	0.434278495511473	0.756474083153005	0.569680135642693	0.775958607940634	p.Thr202Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.242	-3.16	0.918	14.373	14.373	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202E	202	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr202Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.242	-3.385	1.143	10.836	10.836	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202F	202	T	F	missense	low	0.394321586533844	0.264022897861137	6	0.107786896695124	0.183063151006061	0.605580022061627	NA	0.64953710888506	0.63374114361112	NA	0.397849500874327	0.294914055645772	-0.0664815672064879	0.456369277393273	0.526060584565578	NA	0.607649199189957	0.604871683895536	NA	0.528741043444949	0.436696822122372	0.2517807394231	0.523380125686208	p.Thr202Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.242	-4.597	2.355	3.975	NA	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202G	202	T	G	missense	wt-like	0.939166394893949	0.160948253224157	8	0.0569038006374657	0.827636995061069	1.05069579472683	0.559734312360592	1.08342452963906	0.905602136046079	0.992964895722528	0.96673561922875	0.999454852360685	0.997196145456364	1.00821866833754	0.762593634030458	0.573421157795524	0.807663998023612	0.73820657704804	0.731163566133104	0.741241528258536	0.783945739802381	0.824670527625727	0.800545410025628	p.Thr202Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.242	-2.174	-0.068	20.242	20.242	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T202H	202	T	H	missense	wt-like	1.13452235964273	0.0125301321513961	2	0.00886014141341573	1.1171568015745	1.15188791771096	NA	1.14338250105614	1.12566221822931	NA	NA	NA	NA	NA	0.840719599998538	NA	0.835303613780674	0.846135586216403	NA	NA	NA	NA	NA	p.Thr202His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.242	-3.876	1.634	10.718	10.718	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202I	202	T	I	missense	low	0.307786925541669	0.0451242185753309	4	0.0225621092876655	0.263566003922588	0.35200784716075	0.262566328877361	0.28645376819458	0.314664197867314	0.367463407227422	NA	NA	NA	NA	0.444326749922682	0.43203560909735	0.440273889664141	0.448379610181223	0.456848924326578	NA	NA	NA	NA	p.Thr202Ile	1	0	NA	NA	NA	NA	NA	NA	NA	3.747	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.242	-2.672	0.43	8.22	8.22	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T202K	202	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr202Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.242	-2.825	0.583	9.351	8.594	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202L	202	T	L	missense	low	0.533153338644202	0.185499359232095	8	0.065583927409387	0.404611202957114	0.66169547433129	0.243266595684923	0.794365789546295	0.656864217162269	0.636440619394268	0.471845213460218	0.425974798316294	0.671434148412571	0.365035327176776	0.565595268224654	0.422853249224133	0.674412783571963	0.616212452255445	0.574809295271792	0.556381241177516	0.50129308291363	0.64921726836388	0.477507826654977	p.Thr202Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.242	-3.069	0.827	11.834	11.834	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202M	202	T	M	missense	possibly_low	0.628696273971974	0.0937516463600102	2	0.0662924248885663	0.498765508742558	0.758627039201391	NA	NA	NA	NA	0.694988698860541	NA	0.562403849083408	NA	0.615114021741099	NA	NA	NA	NA	0.639733773961626	NA	0.590494269520572	NA	p.Thr202Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.242	-5.04	2.798	1.571	NA	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202N	202	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr202Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.242	-2.626	0.384	12.339	12.339	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T202P	202	T	P	missense	wt-like	0.886115869799468	0.17663361491397	7	0.0667612311766736	0.755266261129635	1.0169654784693	0.728915679691624	0.961162746292861	0.936310743095141	1.07095033158927	0.828994130278127	NA	1.07522188446234	0.601255573186915	0.75130337351291	0.653913679800187	0.75130337351291	0.753267688990124	0.76536419922413	0.689789871702703	NA	0.866694675129562	0.596148986229511	p.Thr202Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.242	-2.488	0.246	25.166	25.166	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.835	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
T202Q	202	T	Q	missense	possibly_wt-like	0.750543556033305	0.363543082080882	5	0.162581408856528	0.43188985011873	1.06919726194788	NA	1.09624944133275	NA	NA	0.35392806016108	0.368188886061872	0.89041692686467	1.04393446574616	0.767159945994477	NA	0.813576066476796	NA	NA	0.512334723894958	0.472811984897642	0.767159945994477	0.818483599877084	p.Thr202Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.242	-3.634	1.392	6.211	6.211	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T202R	202	T	R	missense	possibly_low	0.619112135941111	0.110919483790363	4	0.0554597418951813	0.510413039234669	0.727811232647554	NA	0.534193086069088	0.574871955944017	0.585203417136523	NA	NA	NA	0.782180084614817	0.565238345854692	NA	0.554477545860828	0.575999145848556	0.552339141254546	NA	NA	NA	0.68701797055163	p.Thr202Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.242	-2.997	0.755	26.635	26.635	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T202S	202	T	S	missense	possibly_wt-like	0.780202666256813	0.460358565070011	6	0.187940597190229	0.411845864531015	1.14855946798261	0.742207759566146	0.920487968414167	1.01706948277018	0.821293909341997	1.26403601914657	-0.0838791416981843	NA	NA	0.696395362370348	0.660237739291291	0.732552985449405	0.792876011718803	0.655876990475472	0.852294473794552	0.25	NA	NA	p.Thr202Ser	1	0	NA	NA	NA	NA	NA	NA	NA	0.934	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.242	-2.483	0.241	7.967	7.967	77.42	0.003226747	0	0.092225808	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jun 3, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	medium	2.985	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
T202T	202	T	T	synonymous	possibly_wt-like	0.847886339704748	0.32659541986835	8	0.115468918046689	0.621571418999431	1.07420126041007	0.476589012045319	1.03680037439667	0.937982294302339	1.24826435322482	0.876312931804789	0.246653836197652	1.04089151595401	0.919596399712387	0.755061276600186	0.533862576251989	0.78617104712084	0.754087505395613	0.843125536689934	0.707465234030579	0.412910677943783	0.848204565475562	0.75603504780476	p.Thr202=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T202V	202	T	V	missense	low	0.353960349738762	0.171354554409201	8	0.0605829837049726	0.235219883601038	0.472700815876485	0.555143774497485	0.159760821962802	0.40503652808208	0.398710105453737	0.18249059829338	0.143553341689542	0.564644989730433	0.422342638200633	0.481627577026666	0.571237087671322	0.381870573637702	0.492702942061987	0.470552211991345	0.44829634681612	0.36209525987694	0.591701333065593	0.506290312266634	p.Thr202Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.242	-2.858	0.616	9.82	9.82	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T202W	202	T	W	missense	possibly_low	0.68161183775704	0.151530927018936	4	0.0757654635094679	0.5331142580065	0.830109417507581	NA	0.839659839929421	0.722685347778492	0.687866895705832	NA	NA	NA	0.476235267614416	0.622928477923287	NA	0.695292578519692	0.648494587839831	0.597362368006743	NA	NA	NA	0.533357780674475	p.Thr202Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.242	-5.786	3.544	0.832	NA	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T202X	202	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr202Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T202Y	202	T	Y	missense	wt-like	0.963878376032095	0.119256278488693	8	0.0421634616092133	0.881239509814499	1.04651724224969	0.82616093641606	0.968662417823745	0.909345906759719	1.21455223908713	0.862692992102664	0.930581610868006	0.978693532482219	1.02033737271721	0.752380297936241	0.700180689520146	0.754760595872483	0.740042718612962	0.828341037077519	0.702377671341925	0.75	0.814705142526686	0.806632005753259	p.Thr202Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.6	61.2	33.2	0.503	95.6	-88.1	-107.6	-175.9	18.4049079754601	-0.7	0	0	27.03	0	0	0	0	7	30.871841180273	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.242	-3.394	1.152	9.609	9.609	77.42	0.003226747	0	0.092225808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203A	203	I	A	missense	possibly_low	0.649782015151015	0.186577216741048	7	0.0705195594010587	0.511566218519306	0.787997811782723	NA	0.538351270187418	0.820427497873398	0.80464273651936	0.790469066998526	0.629860677477011	0.299196475247275	0.665526381754113	0.628428874951996	NA	0.556394398758974	0.696432466027774	0.648574592971208	0.675399303256297	0.601782864625227	0.448732517012981	0.628428874951996	p.Ile203Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.964	-2.754	0.79	13.225	13.225	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
I203C	203	I	C	missense	possibly_wt-like	0.760167718662039	0.214198611924163	6	0.087446217137772	0.588776282487737	0.931559154836341	NA	0.873099204071723	0.753347751342702	NA	0.694232353029294	0.392188863119758	0.81654703116592	1.03159110924284	0.687120300894272	NA	0.710707562619542	0.663533039169001	NA	0.639451250182892	0.484640918149705	0.727374108237791	0.812284173056857	p.Ile203Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.964	-3.065	1.101	17.629	17.629	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203D	203	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.964	-4.231	2.267	3.35	NA	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203E	203	I	E	missense	wt-like	0.814537836082058	0.114657000088596	5	0.0512761692588598	0.714038391069513	0.915037281094603	0.71954673125714	0.784884569135151	0.985740980785631	0.712875071225308	NA	NA	NA	0.869641828007059	0.670042100527184	0.649456154128653	0.670042100527184	0.777510870779218	0.608329741923574	NA	NA	NA	0.730945461229209	p.Ile203Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.964	-4.104	2.14	2.768	NA	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I203F	203	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.964	-3.538	1.574	28.024	28.024	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.795	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
I203G	203	I	G	missense	low	0.551848499477818	0.112712225048932	8	0.0398497893273622	0.473744347604679	0.629952651350956	0.563401758454894	0.505240848785968	0.529762930033367	0.610078106211576	0.667049135097979	0.395388181037222	0.720571123898088	0.423295912303448	0.5585616437513	0.575166042531376	0.541131051726695	0.553875313017155	0.563247974485445	0.629297290009093	0.486217774577797	0.675682118706889	0.506769092332529	p.Ile203Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.964	-3.306	1.342	17.08	17.08	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
I203H	203	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.964	-3.415	1.451	10.278	10.278	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203K	203	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.964	-4.063	2.099	3.536	NA	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I203L	203	I	L	missense	possibly_low	0.577117024751607	0.39474170050837	7	0.149198338807412	0.284693654135875	0.86954039536734	0.621597723210434	0.800077181704553	0.82664993062197	0.898078246663006	-0.102405804265542	NA	0.148872956132597	0.846948939194231	0.677045639236709	0.602854316054442	0.677045639236709	0.699484273491024	0.689550879948125	0.341876763507357	NA	0.367769262822115	0.719548001916029	p.Ile203Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.964	-2.354	0.39	33.731	33.731	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.705	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
I203M	203	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.964	-3.369	1.405	6.109	6.109	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.485	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
I203N	203	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.964	-3.349	1.385	12.732	12.732	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.485	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I203P	203	I	P	missense	possibly_low	0.643556313108129	0.224035750137287	8	0.0792085990751452	0.488310311654972	0.798802314561287	1.06402208992436	0.85155531993207	0.657136349207766	0.482842774769795	0.377429423889691	0.663872213696959	0.469650618624291	0.581941714820102	0.601397279239755	0.813349441108251	0.700776194605231	0.616345920087239	0.507448723785724	0.521113372248264	0.618546221972424	0.540537992426257	0.58644863839227	p.Ile203Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.964	-2.818	0.854	20.133	20.133	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203Q	203	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.964	-3.831	1.867	5.733	5.733	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I203R	203	I	R	missense	low	0.398480796452037	0.111003658588215	8	0.0392457198621214	0.321560598974931	0.475400993929143	0.571188162157987	0.255396240803844	0.458774052660899	0.493950410866603	0.362099719215244	0.428829633801625	0.259440758636045	0.358167393474049	0.507510074036943	0.578870630579669	0.425956892221501	0.519058643311446	0.512319994715141	0.515387147666106	0.502700153358745	0.427320350716638	0.474058420297414	p.Ile203Arg	0	0	NA	NA	NA	NA	NA	NA	NA	4.749	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.964	-3.092	1.128	10.074	10.074	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I203S	203	I	S	missense	wt-like	0.924112131266165	0.0775424031114332	5	0.0346780168991712	0.856144467088519	0.992079795443812	NA	0.939939106789023	0.793049761001928	0.995471259601302	0.962913990244996	NA	0.929186538693578	NA	0.739814005269973	NA	0.741519632886133	0.683004987566008	0.732262735874965	0.739814005269973	NA	0.788041002770367	NA	p.Ile203Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.964	-2.734	0.77	8.022	8.022	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.485	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
I203T	203	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.964	-3.032	1.068	8.055	8.055	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.485	Deleterious	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	D	0.5
I203V	203	I	V	missense	possibly_wt-like	0.79570656581642	0.240870948137969	8	0.0851607404095954	0.628794581716848	0.962618549915992	0.722947848501878	1.00341863967106	0.673168806069152	0.317297404524963	0.78005694678455	0.852317470320808	0.908155711108735	1.10828969955022	0.69146786250495	0.651074325851588	0.770782629212209	0.624209078032182	0.434848546525243	0.671509982490645	0.711425742519255	0.7767139379862	0.850805891010742	p.Ile203Val	1	0	NA	NA	NA	NA	NA	NA	NA	-1.589	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.964	-2.084	0.12	23.716	23.716	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
I203W	203	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.964	-5.684	3.72	1.302	NA	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I203X	203	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I203Y	203	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile203Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.1	60.6	29.4	0.831	33.4	-125.9	-105	118.6	12.565445026178	-0.5	0	0	26.43	0	0	0	0	4	30.3965241081937	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.964	-3.4	1.436	8.742	8.742	58.31	0.003270971	0	0.093489808	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.485	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P204A	204	P	A	missense	possibly_low	0.522930965593819	0.403814332354357	7	0.152627471321888	0.223786618751499	0.822075312436138	0.318990704635723	0.411618344589756	0.617247437263038	0.63087495228418	1.30707049201234	0.00879027602403055	NA	0.365924552347665	0.497972652917697	0.458881002174488	0.497972652917697	0.596782305004092	0.572368463382821	0.868369477301627	0.295674225191954	NA	0.477954438269261	p.Pro204Ala	1	0	NA	NA	NA	NA	NA	NA	NA	5.165	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.68	-2.825	1.145	12.003	12.003	77.42	0.002306598	0	0.065926421	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 1, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P204C	204	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.68	-5.4	3.72	1.445	NA	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204D	204	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.68	-3.487	1.807	11.419	11.419	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204E	204	P	E	missense	low	0.466599167331692	0.150883181631538	3	0.0871124455311557	0.295861911485419	0.637336423177964	0.591209737061369	NA	NA	NA	0.298842998482936	NA	0.50974476645077	NA	0.562132435539081	0.588396425789287	NA	NA	NA	0.491758369621361	NA	0.562132435539081	NA	p.Pro204Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.68	-3.256	1.576	10.836	10.836	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204F	204	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.68	-4.57	2.89	5.149	NA	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204G	204	P	G	missense	low	0.358549543552415	0.111910348694381	7	0.0422981359685507	0.275646720440877	0.441452366663952	0.465032867478045	0.15982982576514	0.333153121046959	0.458891658297662	0.279281470803128	NA	0.370383160896723	0.443274700579248	0.487073195565382	0.528364434018333	0.381902383229277	0.457447548080599	0.496944924743252	0.484451399066907	NA	0.487073195565382	0.516803399924577	p.Pro204Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.68	-2.462	0.782	16.067	16.067	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
P204H	204	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.68	-3.16	1.48	10.805	10.805	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204I	204	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.68	-3	1.32	12.712	9.365	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204K	204	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.68	-2.873	1.193	8.781	7.907	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204L	204	P	L	missense	possibly_low	0.481358377982581	0.339827483109296	5	0.151975470571009	0.183491929129876	0.779224826835286	1.07553279934486	0.267290990777551	0.258743143608872	0.426100855693536	NA	NA	NA	0.379124100488084	0.482564467723813	0.818825966365939	0.431440171775984	0.420952991423813	0.482564467723813	NA	NA	NA	0.484583885675611	p.Pro204Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.68	-2.968	1.288	14.443	14.443	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	3	0	0	2	0	0	2	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P204M	204	P	M	missense	low	0.427041907592218	0.0947820422608985	4	0.0473910211304493	0.33415721298596	0.519926602198475	NA	0.330700907884328	0.371018233545315	0.541454922091185	NA	NA	NA	0.464993566848043	0.501865122024788	NA	0.460671076401268	0.476018585742001	0.533153171326946	NA	NA	NA	0.527711658307575	p.Pro204Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.68	-4.985	3.305	2.455	NA	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204N	204	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.68	-3.384	1.704	9.195	9.195	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204Q	204	P	Q	missense	low	0.383569018787092	0.112029206013632	8	0.0396083056315918	0.305938166260517	0.461199871313667	0.447124044139848	0.423394622932843	0.373245799925222	0.494515703457552	0.228200547463209	0.198270867362783	0.420280231005207	0.48352033401007	0.507984611848212	0.519843836393614	0.503401319044289	0.47711110115804	0.512567904652134	0.465370741929663	0.389064033944752	0.51394742785029	0.537016691116558	p.Pro204Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.68	-3.178	1.498	6.689	6.689	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P204R	204	P	R	missense	low	0.273593764771503	0.269515999275786	8	0.0952882953630883	0.0868321377116348	0.460355391831371	-0.0304525321864216	0.625247277768448	0.589557131395891	0.508415617957838	0.00294457875084757	0.0697481995914024	0.125290111023302	0.297999733870716	0.41253422344388	0.292624115420223	0.596451995832344	0.583201526308746	0.518663733578874	0.381229116718289	0.325718720956414	0.355067698260743	0.443839330169471	p.Pro204Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.68	-2.993	1.313	25.013	25.013	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.435	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P204S	204	P	S	missense	low	0.365678683276209	0.175113165045903	2	0.123823706478997	0.122988678145115	0.608368688407303	NA	0.489502389755206	NA	NA	NA	NA	NA	0.241854976797212	0.474758311002667	NA	0.533875886984838	NA	NA	NA	NA	NA	0.415640735020497	p.Pro204Ser	1	0	yes	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.68	-2.421	0.741	8.622	8.622	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	1	0	0	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.125	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
P204T	204	P	T	missense	low	0.292217559324509	0.0643665482551383	3	0.0371620439619111	0.219381291567269	0.365053827081749	NA	0.228471889117475	0.290993269452084	0.357187519403967	NA	NA	NA	NA	0.436770145054223	NA	0.413545219219049	0.436770145054223	0.452342417884336	NA	NA	NA	NA	p.Pro204Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.68	-3.118	1.438	6.895	6.895	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
P204V	204	P	V	missense	low	0.265290486438572	0.195062359828117	7	0.0737266420363703	0.12078892334621	0.409792049530935	0.384147507823337	0.068883398553922	0.500056265027073	NA	0.0864840721394321	0.244332163871303	0.0778043176682665	0.495325679986674	0.412434277599181	0.489881079175111	0.339977610873166	0.539305606017063	NA	0.412434277599181	0.411766389059035	0.329492163703668	0.542945903195114	p.Pro204Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.68	-3.001	1.321	20.844	20.844	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.435	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P204W	204	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.68	-5.747	4.067	1.078	NA	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P204X	204	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P204Y	204	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro204Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.8	63.4	26.9	0.269	19.4	-139.3	-59	143.4	0	-0.9	0	0	29.33	0	0	0	0	6	27.3197082316045	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.68	-3.393	1.713	12.444	12.444	77.42	0.002306598	0	0.065926421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M205A	205	M	A	missense	wt-like	0.943831984215085	0.188613230381581	8	0.0666848471121581	0.813132085560695	1.07453188286947	0.713103914135237	0.990810639988239	0.741961788291642	0.978645670212755	1.04122579790855	1.26396384044538	0.773682259740884	1.04726196299799	0.744927200631206	0.646390813026745	0.764970553545503	0.657948765554556	0.724883847716909	0.769066427781654	0.914314996284501	0.704287425560605	0.820154828906376	p.Met205Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.803	-2.975	0.172	11.788	11.788	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.35	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
M205C	205	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.803	-5.38	2.577	1.445	NA	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M205D	205	M	D	missense	low	-0.216124346186807	0.187022961746613	2	0.132245204488623	-0.475320184112642	0.0430714917390279	NA	NA	NA	NA	-0.348369550675429	-0.0838791416981843	NA	NA	0.25	NA	NA	NA	NA	0.25	0.25	NA	NA	p.Met205Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.803	-3.2	0.397	15.554	15.554	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.145	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M205E	205	M	E	missense	wt-like	0.819326680653666	0.116598750543117	8	0.0412238835934583	0.738529353507616	0.900124007799715	0.860009943902302	0.843331290335794	0.708297140414047	0.754544296904234	0.727915729955347	0.724897846470728	0.881077149332535	1.05454004791434	0.674509160497456	0.716285252468802	0.696985055368139	0.641437856109356	0.626603845065951	0.652033265626773	0.648624089755578	0.762129603524624	0.823810232914042	p.Met205Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.803	-3.561	0.758	6.339	6.339	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
M205F	205	M	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.803	-3.834	1.031	13.582	13.582	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
M205G	205	M	G	missense	low	0.630223261529684	0.109020325131574	8	0.0385445055938491	0.554677418763837	0.705769104295531	0.388623402868435	0.644523114268492	0.689975485392996	0.763700176857019	0.652599782635292	0.676426921384795	0.6112814319155	0.614655776914939	0.62035966148697	0.492010604938448	0.605337832055037	0.632451955290233	0.630619170330347	0.623899910279658	0.624734094522485	0.616819412694282	0.602879212514855	p.Met205Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.803	-2.759	-0.044	15.561	15.561	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
M205H	205	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.803	-3.495	0.692	14.671	14.671	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M205I	205	M	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.803	-2.404	-0.399	12.712	11.521	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	neutral	neutral	low	1.8	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
M205K	205	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.803	-2.714	-0.089	20.145	20.145	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.005	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
M205L	205	M	L	missense	possibly_low	0.519051703389324	0.357092895176632	7	0.134968427940775	0.254518445575416	0.783584961203232	NA	0.760010652013595	0.548360897465125	0.695781811557075	-0.142072411433313	0.552207302665648	0.277588999096808	0.94148467236033	0.563509636895652	NA	0.658575643351202	0.562996731938482	0.600833466551826	0.32705978523683	0.563509636895652	0.43709487312135	0.767028390212523	p.Met205Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.803	-2.427	-0.376	18.729	18.729	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
M205N	205	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.803	-2.494	-0.309	15.011	15.011	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
M205P	205	M	P	missense	low	0.411982361825287	0.0897810501808373	4	0.0448905250904186	0.323998549400975	0.499966174249599	0.405323993981643	0.423293973929088	0.519197508310932	NA	NA	NA	NA	0.300113971079484	0.501655637794312	0.499956354041188	0.503354921547437	0.548693475917781	NA	NA	NA	NA	0.444901201699539	p.Met205Pro	0	0	NA	NA	NA	NA	NA	NA	NA	5.0405	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.803	-4.435	1.632	1.972	NA	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
M205Q	205	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.803	-3.331	0.528	7.538	7.538	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.35	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
M205R	205	M	R	missense	possibly_wt-like	0.865879220745693	0.278015692728591	8	0.098293390802331	0.673227714854803	1.05853072663658	0.905185187638008	0.739406594421236	0.889883143447221	0.358204687895974	1.09105926423647	1.19912342011043	1.0994229109606	0.6447485572556	0.734137865547259	0.73777857267201	0.649077519558327	0.730497158422508	0.452788498694173	0.787681112536585	0.882356923894355	0.87972918810264	0.617993252969645	p.Met205Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.803	-3.138	0.335	12.72	12.72	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.695	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
M205S	205	M	S	missense	possibly_low	0.547483442110119	0.421067289816766	5	0.188307016626379	0.178408471486231	0.916558412734006	NA	0.843836226254688	0.773005488073419	0.186441286931722	0.00488723065123652	0.929246978639529	NA	NA	0.67317422455251	NA	0.6972178223289	0.67317422455251	0.37746139447842	0.381954770688984	0.749342196223412	NA	NA	p.Met205Ser	0	0	NA	NA	NA	NA	NA	NA	NA	3.928	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.803	-2.682	-0.121	7.967	7.967	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
M205T	205	M	T	missense	wt-like	1.10141057270696	0.14115611688253	7	0.0533519973295343	0.996842579437794	1.20597856597612	NA	1.00336343222441	1.0998087547026	1.05853613915955	1.28446983963102	1.28623255991781	1.07543033311671	0.902032950196605	0.833455691369843	NA	0.770757179508423	0.833455691369843	0.759919936001241	0.859927278708304	0.925290639953368	0.866806944197562	0.747213839411844	p.Met205Thr	1	0	NA	NA	NA	NA	NA	NA	NA	3.55	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.803	-2.811	0.008	12.509	12.509	77.42	0.00311317	0	0.088979577	3.229e-05	1	30968	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.5
M205V	205	M	V	missense	possibly_low	0.701375970356606	0.186206976145059	8	0.0658341077682066	0.572343490176592	0.830408450536619	0.318555544632083	0.685563915273559	0.811113923849429	0.703855687966515	0.800953935126916	0.699505962129035	0.628193143147922	0.963265650727387	0.631018536021418	0.45867396326281	0.624256950619792	0.691864600714581	0.604374277494697	0.679315798119864	0.636109123416338	0.625927948626497	0.777967844276188	p.Met205Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.428	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.803	-2.752	-0.051	20.844	20.844	77.42	0.00311317	0	0.088979577	1.448e-05	4	276190	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Sep 29, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
M205W	205	M	W	missense	possibly_wt-like	0.735752579995816	0.31401646750397	7	0.118687068656357	0.503130199998724	0.968374959992909	0.6531594750833	0.771250666903598	0.967848243375803	0.999539824316081	0.837843574036118	0.0743417237292452	NA	0.846284552526571	0.693095473699713	0.617870656489624	0.663757101051	0.768735333658658	0.73404701120113	0.693095473699713	0.327982743554737	NA	0.719214315003123	p.Met205Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.803	-4.328	1.525	10.843	10.843	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M205X	205	M	X	nonsense	possibly_low	0.284087777654861	0.769349085183134	5	0.344063370579353	-0.390264037080128	0.958439592389851	-0.0755302785798194	-0.0922520103635678	-0.0524084982976996	-0.0188295518945649	1.65945922740996	NA	NA	NA	0.271177182163137	0.271177182163137	0.26569689920007	0.268347902491223	0.287439551746388	1	NA	NA	NA	p.Met205Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M205Y	205	M	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met205Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.4	63.5	23.9	0.818	53.3	125.6	-108.7	91.3	31.5270935960591	-2.9	0	0	35.12	0	0	0	0	8	28.3515974481157	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.803	-3.047	0.244	11.263	11.263	77.42	0.00311317	0	0.088979577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
F206A	206	F	A	missense	possibly_wt-like	0.73171605976841	0.0974352883717949	8	0.0344485765672815	0.664198090377868	0.799234029158952	0.895538683641749	0.670520560563616	0.72173935814248	0.571080257790244	0.675827810937241	0.757712539763561	0.806922769436845	0.754386497871542	0.656414090401653	0.733188992581504	0.617322217271534	0.648030624893506	0.54614540795653	0.632576457511476	0.6647975559098	0.722190544459085	0.673058695613714	p.Phe206Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.027	-2.933	0.906	8.266	8.266	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F206C	206	F	C	missense	wt-like	0.945345742463804	0.181641176023691	7	0.0686539113725705	0.810786548775761	1.07990493615185	0.892883327633444	0.894811336985366	0.870001678810689	0.992079887349444	0.694280706975093	1.29247278171178	NA	0.980890477780817	0.730775444347108	0.73192563654354	0.720716490487111	0.720746245136699	0.730775444347108	0.639469312210763	0.928366274855053	NA	0.786819879418128	p.Phe206Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.027	-4.176	2.149	13.551	13.551	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F206D	206	F	D	missense	low	0.297738993869001	0.248635590524491	4	0.124317795262245	0.0540805925175762	0.541397395220427	NA	NA	NA	NA	-0.0393364203031067	0.5571613694255	0.308959629342078	0.364171397011535	0.465532403355161	NA	NA	NA	NA	0.36543556418205	0.565951361105938	0.453990887302191	0.477073919408131	p.Phe206Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.027	-3.315	1.288	9.746	9.746	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F206E	206	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe206Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.027	-4.072	2.045	5.152	NA	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F206F	206	F	F	synonymous	possibly_wt-like	0.874113467785846	0.426330730888546	5	0.190660899032792	0.500424972421547	1.24780196315015	NA	0.64753498946578	0.493270272103133	0.5812023564832	1.46491367676971	NA	1.18364604410741	NA	0.606726255832456	NA	0.606726255832456	0.53597739907813	0.55058446993857	0.9273298776406	NA	0.925091211143853	NA	p.Phe206=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	NA	NA	NA	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F206G	206	F	G	missense	low	0.611144969714747	0.0541532699030184	8	0.0191460721859248	0.57361935778493	0.648670581644563	0.616556319950826	0.60637084962004	0.638253272830518	0.707866429281568	0.590221081817643	0.62023314448459	0.512860566915369	0.596798092817418	0.598746725651383	0.600455734761418	0.587750280137889	0.607084668781562	0.606133194279794	0.600599105886442	0.597037716541347	0.563810585082871	0.593910225374969	p.Phe206Gly	0	0	NA	0.246186940201714	-1.65426372404182	0.056670611831425	0.435703268572003	NA	NA	10.817	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.027	-2.573	0.546	18.471	18.471	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F206H	206	F	H	missense	possibly_wt-like	0.708815352995719	0.181807313800346	6	0.0742225250528184	0.563341877050573	0.854288828940865	0.927594999095793	NA	0.683853452822761	0.622074509529679	0.793309833267631	0.408372902290773	NA	0.817686420967677	0.652954913129452	0.748440634755694	NA	0.629449389341667	0.568509015649534	0.676460436917236	0.492617589070721	NA	0.704850958994821	p.Phe206His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.027	-3.241	1.214	18.097	18.097	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F206I	206	F	I	missense	wt-like	0.945449891912682	0.174691122898336	4	0.0873455614491679	0.774255737262883	1.11664404656248	NA	0.855423920268518	0.743776147756834	1.10201489113762	NA	NA	NA	1.08058460848775	0.740773581972229	NA	0.702559554253496	0.65883862262182	0.778987609690962	NA	NA	NA	0.836891062856563	p.Phe206Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.027	-2.546	0.519	11.926	11.926	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.505	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
F206K	206	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe206Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.027	-3.281	1.254	9.282	9.282	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.705	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F206L	206	F	L	missense	possibly_low	0.608840913560716	0.451138187962142	6	0.184176393998509	0.247861814521179	0.969820012600254	NA	0.94729777152766	0.939907168193388	0.93691999983805	-0.015712815175148	0.0860247026271456	NA	0.758608654353202	0.690882128084519	NA	0.744911853487563	0.755031564535162	0.706584990666205	0.374259874322112	0.333740964791166	NA	0.675179265502833	p.Phe206Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.027	-2.513	0.486	27.302	27.302	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	neutral	neutral	medium	2.16	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
F206M	206	F	M	missense	possibly_low	0.701028339769307	0.315636002134804	7	0.119299195209621	0.467206213773838	0.934850465764777	0.700643266438769	0.829614851662423	0.814359645215398	1.05124913711661	0.337341339039589	0.207885668310247	NA	0.966104470602116	0.690662007981329	0.640462329442984	0.690662007981329	0.693456472750574	0.756724210024534	0.506138956119889	0.393802906751385	NA	0.779393636042346	p.Phe206Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.027	-3.413	1.386	7.797	7.797	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.155	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F206N	206	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe206Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.027	-3.211	1.184	10.61	10.61	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F206P	206	F	P	missense	low	0.557425292830447	0.144896400622879	8	0.0512286137249804	0.457019054951571	0.657831530709322	0.671343394424374	0.767390129377255	0.297698177223634	0.653291270826238	0.464977227685893	0.564528285782175	0.550651102816152	0.489522754507852	0.575890743707577	0.626522138332944	0.6619774582225	0.440058583580507	0.582199174427617	0.553815788691245	0.569582312987536	0.584164318032737	0.540031395148659	p.Phe206Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.027	-4.501	2.474	1.233	NA	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F206Q	206	F	Q	missense	possibly_low	0.678117124186727	0.137593775256889	2	0.0972934915332039	0.487425384851495	0.86880886352196	0.775410615719931	NA	0.580823632653523	NA	NA	NA	NA	NA	0.627476519477044	0.676034878608334	NA	0.578918160345754	NA	NA	NA	NA	NA	p.Phe206Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.027	-3.631	1.604	10.67	10.67	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.705	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
F206R	206	F	R	missense	possibly_low	0.63903620777181	0.11448837773741	8	0.0404777541325849	0.559701267496876	0.718371148046744	0.776919203302706	0.516937193883528	0.787323880321117	0.694668996290065	0.575690444737004	0.469883076631978	0.640868712366482	0.649998154641597	0.610487646379007	0.676752629156862	0.54652286997234	0.680196715287069	0.600345439701401	0.595171363277398	0.522934274159626	0.63275492645871	0.620629853056614	p.Phe206Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.027	-3.4	1.373	10.757	10.757	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F206S	206	F	S	missense	possibly_low	0.645628880419971	0.097932708254136	8	0.0346244410532317	0.577766222970807	0.713491537869135	0.686032263575589	0.640889763786151	0.56015931030547	0.726670989813589	0.828138545733493	0.619604271910942	0.552521899908243	0.55101399832629	0.60019534052734	0.633510757363693	0.603662918630364	0.568783292567672	0.614379963282824	0.689470278510555	0.596727762424316	0.585171916985971	0.570915252876869	p.Phe206Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.027	-3.082	1.055	8.186	8.186	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F206T	206	F	T	missense	possibly_wt-like	0.719560090937119	0.161757777629323	7	0.0611386931768108	0.599730454248725	0.839389727625513	NA	0.437769200657295	0.585427302462152	0.773968050005973	0.935496556009282	0.812377208976225	0.745801399158783	0.746080919290123	0.668887234909221	NA	0.510027757457458	0.581176041539172	0.635122161924734	0.729572556446635	0.691740278471705	0.689270978263049	0.668887234909221	p.Phe206Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.027	-3.095	1.068	9.641	9.641	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F206V	206	F	V	missense	possibly_wt-like	0.806154744619345	0.184000268885315	8	0.065053918934477	0.678651406454582	0.933658082784108	0.413717033388184	0.829941110078126	0.85707897665005	0.686322899605634	0.854161189668015	1.0262043451402	0.877221692839065	0.904590709585484	0.706799497218396	0.503949565112683	0.690812407620183	0.714408274041994	0.596685246137384	0.699190720394798	0.797129834264315	0.760053080130673	0.748498469095095	p.Phe206Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.027	-2.69	0.663	11.157	11.157	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	3.055	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F206W	206	F	W	missense	possibly_wt-like	0.82961353563564	0.196573793088102	8	0.069499331048079	0.693397349831779	0.965829721439501	1.04690441373988	1.07149591293388	0.88007635740314	0.784607260972684	0.463865296839816	0.825274258586057	0.677617523917214	0.887067260692451	0.711892139032676	0.805205252722231	0.802165106475885	0.725687396059598	0.639788004291407	0.553400440458537	0.698096882005754	0.652547593556428	0.739697350937233	p.Phe206Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.027	-3.464	1.437	14.416	14.416	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F206X	206	F	X	nonsense	low	-0.012284352685657	0.02837273484071	7	0.0107238857718995	-0.0333027825729016	0.00873407720158752	-0.0437400415610264	-0.0100264297530772	0.00619187327550527	-0.0238118543881854	0.00602553191422318	NA	0.028532679703908	-0.0491622279909466	0.297088599023035	0.28630223046566	0.303601508041248	0.297088599023035	0.285254555309054	0.382379969269937	NA	0.302954785039286	0.269477909372077	p.Phe206Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F206Y	206	F	Y	missense	wt-like	1.05126218287004	0.174184134551478	2	0.12316678271646	0.809859724654108	1.29266464108597	NA	NA	NA	NA	1.1744289655865	NA	0.92809540015358	NA	0.803138086215123	NA	NA	NA	NA	0.818822849668248	NA	0.787453322761999	NA	p.Phe206Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	64.2	20.6	0.561	78.1	24.5	-120.2	-15.2	17.5438596491228	-3	0	0	33.82	0	0	0	0	5	27.1791673503807	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.027	-2.823	0.796	9.766	9.766	72.7	0.003028781	0	0.0865676	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.055	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
S207A	207	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.226	-2.851	0.625	11.285	11.285	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S207C	207	S	C	missense	possibly_wt-like	0.880365542157194	0.333308224442471	2	0.235684505728519	0.418432399215173	1.34229868509922	NA	0.644681036428675	1.11605004788571	NA	NA	NA	NA	NA	0.723415952558062	NA	0.605410631513121	0.841421273603003	NA	NA	NA	NA	NA	p.Ser207Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.226	-5.464	3.238	1.529	NA	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S207D	207	S	D	missense	possibly_wt-like	0.740290933732762	0.420898603684887	6	0.171831135412982	0.403508096900692	1.07707377056483	1.32971015428409	0.850618400991181	0.715337588513011	0.324535571257451	0.211293861112141	NA	NA	1.0102500262387	0.672617575978424	0.939757583471861	0.700344290741414	0.644890861215433	0.438022855701285	0.459055455037823	NA	NA	0.801565655584489	p.Ser207Asp	0	0	NA	NA	NA	NA	NA	NA	NA	-2.478	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.226	-2.568	0.342	15.455	15.455	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S207E	207	S	E	missense	wt-like	1.08751649641696	0.08866219210571	6	0.0361961883559347	1.0165732708617	1.15845972197222	NA	1.13844909782725	1.02691116893709	1.19434273714214	0.98891032467469	1.16538460358946	1.01110104633113	NA	0.825818872109081	NA	0.833029397919152	0.797702890932886	0.819478128852523	0.749524619558937	0.865727982638803	0.83215961536564	NA	p.Ser207Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.226	-2.957	0.731	9.509	9.509	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.455	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S207F	207	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.226	-3.541	1.315	17.408	17.408	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S207G	207	S	G	missense	wt-like	0.96618690076696	0.198312715008266	7	0.0749551608191282	0.819277485106061	1.11309631642786	1.00981888643767	1.01788908061991	1.15616275111317	1.15733428720668	0.573828046791506	NA	0.949444066118265	0.898831187081513	0.787560829642315	0.787560829642315	0.777453258958492	0.861094647671812	0.803248016095664	0.594475687194672	NA	0.798951573197554	0.745605760108425	p.Ser207Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.226	-2.416	0.19	18.218	18.218	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
S207H	207	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.226	-3.307	1.081	17.658	17.658	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.76	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S207I	207	S	I	missense	wt-like	0.848974691050512	0.0578600973753676	4	0.0289300486876838	0.792272837551662	0.905676544549363	NA	0.838231079601306	0.81385266823377	0.933724021866486	NA	NA	NA	0.810090994500486	0.697835057431843	NA	0.694633944053838	0.693207824641587	0.705183389601113	NA	NA	NA	0.701036170809849	p.Ser207Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.226	-3.593	1.367	8.085	8.085	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S207K	207	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.226	-2.573	0.347	10.244	10.244	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S207L	207	S	L	missense	possibly_wt-like	0.977364234609915	0.387294608637915	5	0.173203414446711	0.637891780294997	1.31683668892483	NA	0.828003432514279	0.734521519037522	0.908033009310926	1.65945922740996	0.756803984776889	NA	NA	0.689919170873508	NA	0.689919170873508	0.654299667178439	0.693916556449716	1	0.664349753969522	NA	NA	p.Ser207Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.226	-2.99	0.764	13.977	13.977	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.105	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S207M	207	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.226	-4.165	1.939	5.546	5.546	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S207N	207	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.226	-2.372	0.146	16.268	16.268	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.17	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
S207P	207	S	P	missense	wt-like	0.947368504447091	0.262674566441528	6	0.10723644269809	0.73718893892864	1.15754806996554	1.2314859454656	0.800666401101287	0.642566879531653	0.697255813679583	1.16425202398401	NA	NA	1.14798396292041	0.746169318236268	0.893024811332464	0.677317259462301	0.609200287809678	0.601479892454394	0.815021377010235	NA	NA	0.870742257661103	p.Ser207Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.226	-3.411	1.185	35.969	35.969	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.755	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S207Q	207	S	Q	missense	possibly_low	0.624686153122103	0.849517969039937	3	0.490469428106632	-0.336616261484853	1.58598856772906	NA	1.00373038905054	NA	NA	-0.348369550675429	NA	NA	1.2186976209912	0.770926340429546	NA	0.770926340429546	NA	NA	0.25	NA	NA	0.906258055028086	p.Ser207Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.226	-3.009	0.783	9.343	9.343	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S207R	207	S	R	missense	possibly_low	0.650927121596685	0.205910631370816	5	0.0920860338070093	0.470441811855809	0.831412431337561	NA	0.812445924767066	0.547017433388938	NA	0.412082899341709	0.569437788682682	NA	0.913651561803028	0.572002072888591	NA	0.682747421628037	0.562337826674258	NA	0.534057756188112	0.572002072888591	NA	0.753049264515808	p.Ser207Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.226	-2.969	0.743	26.635	26.635	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	neutral	neutral	low	1.41	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
S207T	207	S	T	missense	possibly_wt-like	0.749818350750605	0.361493463996274	6	0.147579088690339	0.460568652046298	1.03906804945491	NA	0.969299845723859	0.992612256930289	0.905865179720532	0.082671678321747	NA	0.57975768613449	0.968703457672714	0.72401014542429	NA	0.755054439406805	0.780880905083748	0.692965851441775	0.411010204294489	NA	0.599840931497543	0.780698972248632	p.Ser207Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.226	-2.798	0.572	20.564	20.564	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.845	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
S207V	207	S	V	missense	wt-like	1.02040888872363	0.0822832241668891	3	0.0475062416225437	0.927298366102589	1.11351941134468	NA	1.03613702912093	0.931396816830358	1.0936928202196	NA	NA	NA	NA	0.775337952663835	NA	0.785865256112537	0.75085764175383	0.775337952663835	NA	NA	NA	NA	p.Ser207Val	0	0	NA	NA	NA	NA	NA	NA	NA	1.533	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.226	-3.423	1.197	10.489	10.489	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.455	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S207W	207	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.226	-4.346	2.12	13.43	13.43	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S207X	207	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S207Y	207	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser207Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	61.3	18.4	0.828	132.7	-28.6	-154.8	109.2	24.4755244755245	-5.5	0	0	46.65	0	0	0	0	7	30.613955279578	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.226	-3.917	1.691	10.632	10.632	42.43	0.003476119	0	0.099353278	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G208A	208	G	A	missense	wt-like	0.971452894438765	0.276365483812572	8	0.0977099538448852	0.779944903971719	1.16296088490581	0.91863904830741	0.9651532078597	0.986941068849382	1.00465317961713	1.43846454520476	0.586068838769654	1.21985725112526	0.651846015776822	0.748661256402017	0.744179603666519	0.753142909137514	0.778099456925104	0.73628948104914	0.917450126493382	0.580199063282207	0.944594327992173	0.621557937721323	p.Gly208Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.838	-2.624	0.786	25.3	25.3	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
G208C	208	G	C	missense	wt-like	0.924594555523232	0.162072239337397	7	0.0612575485305846	0.804531966622071	1.04465714442439	0.943861619651155	0.958546466583985	0.833050698228675	1.19240618197895	0.737860855825549	0.76145453036811	NA	1.04498153602619	0.750097312597952	0.756179910857134	0.750097312597952	0.702623545724565	0.818628849601078	0.655748146339741	0.666641880884958	NA	0.819009488890739	p.Gly208Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.838	-4.155	2.317	15.23	15.23	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G208D	208	G	D	missense	wt-like	1.02787955811875	0.290835163607497	5	0.130065439214727	0.772955981624502	1.282803134613	NA	1.3846183116184	1.09242022657951	1.20126058046419	0.73506777087117	NA	NA	0.726030901060482	0.822511959703236	NA	0.946509262557572	0.829831969558845	0.822511959703236	0.654704823453523	NA	NA	0.658817152211259	p.Gly208Asp	1	0	NA	NA	NA	NA	NA	NA	NA	0.963	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.838	-3.03	1.192	28.647	28.647	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.705	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G208E	208	G	E	missense	low	0.241023774156418	0.269516544493306	2	0.190576976253183	-0.132500235582365	0.614547783895201	NA	NA	NA	NA	0.4316007504096	0.0504467979032352	NA	NA	0.428776999530874	NA	NA	NA	NA	0.541348411875833	0.316205587185915	NA	NA	p.Gly208Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.838	-2.876	1.038	10.983	10.983	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G208F	208	G	F	missense	possibly_wt-like	0.75042292644152	0.152795205567646	6	0.0623783814640661	0.62816354535805	0.872682307524991	0.463775767004185	0.858383011972046	0.824009450340245	0.704668435827261	0.781001653069962	NA	NA	0.870699240435423	0.685026054729671	0.527766335131023	0.703923645728614	0.698189243435105	0.60473070932164	0.671862866024237	NA	NA	0.731476544566766	p.Gly208Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.838	-3.605	1.767	13.008	13.008	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G208G	208	G	G	synonymous	wt-like	0.894812140551737	0.135970231532692	8	0.0480727363781358	0.800591308612303	0.989032972491172	0.727916895824034	1.14515891499517	0.859680218821849	0.789856050185295	0.942406720877644	0.896815839012953	0.788005051019881	1.00865743367707	0.723918912045173	0.653438481888572	0.836122510710302	0.715684059670282	0.642089868890065	0.732153764420063	0.73335777319643	0.712001586311189	0.800765779064872	p.Gly208=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G208H	208	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly208His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.838	-4.011	2.173	7.819	7.819	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G208I	208	G	I	missense	possibly_low	0.642041634052164	0.49399270030569	6	0.201671675401425	0.246772413563518	1.03731085454081	0.824052837047048	0.803162824246055	0.923101882117639	0.955704793443296	-0.348369550675429	NA	NA	0.694597018134377	0.688822886929643	0.699177705340947	0.678468068518339	0.74678937059907	0.714823090853033	0.25	NA	NA	0.643029545588737	p.Gly208Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.838	-3.472	1.634	13.404	7.411	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G208K	208	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly208Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.838	-2.462	0.624	10.794	10.794	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G208L	208	G	L	missense	wt-like	0.85646665269893	0.181654240591386	8	0.0642244726767308	0.73058899932646	0.982344306071399	0.583206334693905	0.615690382276584	0.928207155844155	0.889710839395004	0.781449712613208	1.09244819351582	0.981749203136739	0.979271400116023	0.717587302631986	0.584588594871862	0.592046427848931	0.749293264669133	0.68588134059484	0.672030233212666	0.829779618008067	0.816350906552052	0.786006700806909	p.Gly208Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.838	-3.002	1.164	14.722	14.722	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
G208M	208	G	M	missense	wt-like	0.879174405613027	0.214761112688004	7	0.0811720707799965	0.720080070333698	1.03826874089236	0.533426115659425	0.917261921686774	0.999931657734616	1.10893906914276	0.625429273483314	NA	0.955080499499769	1.01415230208453	0.782024218626702	0.56090433555157	0.731065832201021	0.784470723231046	0.782024218626702	0.613750697315684	NA	0.801987318976287	0.803525566045802	p.Gly208Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.838	-5.007	3.169	2.589	NA	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G208N	208	G	N	missense	possibly_wt-like	0.801986165393733	0.417545225550691	3	0.241069848370534	0.329497944828954	1.27447438595851	NA	NA	NA	NA	0.902259034209839	NA	1.16026499663416	0.3434344653372	0.717157084758181	NA	NA	NA	NA	0.717157084758181	NA	0.912498333455954	0.466658835767267	p.Gly208Asn	0	0	NA	NA	NA	NA	NA	NA	NA	-1.537	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.838	-2.492	0.654	15.797	15.797	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.25	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
G208P	208	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly208Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.838	-4.326	2.488	2.594	NA	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G208Q	208	G	Q	missense	possibly_low	0.53397392532206	0.785199521903218	2	0.5552199065222	-0.554237094961148	1.62218494560527	NA	NA	NA	NA	NA	-0.0212459812001407	NA	1.08919383184426	0.561042601428096	NA	NA	NA	NA	NA	0.28087017429684	NA	0.841215028559352	p.Gly208Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.838	-2.901	1.063	8.706	8.706	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G208R	208	G	R	missense	possibly_low	0.702792438828506	0.20022575886321	8	0.0707904959301993	0.564045616357586	0.841539261299426	0.774915064872492	0.902215809538694	0.922566163409071	0.659217540684067	0.426215498427645	0.421956988595515	0.867364602585874	0.64788784251469	0.647684530021253	0.675799107151222	0.724129827720187	0.746526626039334	0.584798149207374	0.539336816549304	0.499312814228708	0.754744116447202	0.619569952891284	p.Gly208Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.838	-3.277	1.439	10.415	10.415	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G208S	208	G	S	missense	wt-like	1.0322663821091	0.145235337266168	8	0.0513484459244112	0.931625277435154	1.13290748678305	0.957680821076064	1.02856323554094	1.04046149436112	1.11778552889737	1.25002477274087	0.745447825813774	1.01681205602004	1.10135532242264	0.795126264294425	0.762754762404497	0.782373864735765	0.804348681402541	0.785903847186309	0.847060743249911	0.658752613353491	0.83523552745081	0.847323113572151	p.Gly208Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.838	-2.65	0.812	19.591	19.591	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.505	Deleterious	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	D	0.5
G208T	208	G	T	missense	possibly_wt-like	0.73786799076643	0.180453614915219	6	0.0736698797971626	0.593477679618596	0.882258301914264	0.857418385891827	0.570729462811438	0.812153749479628	0.848020763917589	0.453139846354881	NA	NA	0.885745736143216	0.679986339748256	0.715052250020155	0.571320200647945	0.692374585755311	0.667598093741201	0.549394078984143	NA	NA	0.739033617800147	p.Gly208Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.838	-3.025	1.187	8.604	8.604	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G208V	208	G	V	missense	wt-like	0.788889909378948	0.105077842946614	8	0.037150627650003	0.716076017181885	0.861703801576012	0.669257015780694	0.770072267724886	0.868115317363575	0.936274048768002	0.869254466108642	0.621081978337176	0.790316621040236	0.786747559908376	0.697070303115582	0.625529488364831	0.663213878861552	0.719821074520108	0.706301707828891	0.704828630088106	0.59745608356562	0.713246582651351	0.689311976143058	p.Gly208Val	1	0	NA	NA	NA	NA	NA	NA	NA	2.45	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.838	-2.92	1.082	21.979	21.979	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
G208W	208	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly208Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.838	-4.209	2.371	14.046	14.046	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G208X	208	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly208Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G208Y	208	G	Y	missense	wt-like	1.06095259595004	0.0804203142258512	2	0.0568657495342524	0.949497774909031	1.17240741699105	1.00408684641579	NA	NA	NA	NA	NA	NA	1.11781834548429	0.820212647255692	0.78483365959474	NA	NA	NA	NA	NA	NA	0.855591634916645	p.Gly208Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.9	59.3	19	0.914	123.5	-46.4	49.3	56.3	86.5979381443299	-0.7	0	0	49.58	0	0	0	0	4	33.7523394427705	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.838	-3.598	1.76	12.208	12.208	86.35	0.003131829	0	0.089512875	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209A	209	G	A	missense	wt-like	1.04176048243202	0.364548520387547	6	0.148826310239347	0.750066274410921	1.33345469045313	0.772822309714999	0.754813598953402	0.750156238681977	1.24837609518768	1.65945922740996	NA	NA	1.06493542464414	0.751917357032786	0.674803423387564	0.656179889354564	0.661967753925976	0.843174541299961	1	NA	NA	0.829031290678009	p.Gly209Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.584	-2.529	0.945	25.444	25.444	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.455	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
G209C	209	G	C	missense	possibly_wt-like	0.763361764491989	0.246124000195179	8	0.0870179747753852	0.59280966792462	0.933913861059359	1.0032506119708	0.605798899327683	0.438675292912954	0.402289871745001	0.855021794402558	0.853971647940048	0.957037266652606	0.99084873098427	0.70587661515497	0.784435798881551	0.587486620678783	0.50920115710319	0.472122124015538	0.699512188817779	0.71224104149216	0.803041220836226	0.791821392740334	p.Gly209Cys	0	0	NA	NA	NA	NA	NA	NA	NA	3.566	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.584	-3.747	2.163	12.472	12.472	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209D	209	G	D	missense	possibly_wt-like	0.848633198870611	0.274664038570198	8	0.0971084021105353	0.658304228137728	1.03896216960349	0.716132277621976	0.992316982856146	1.01001857976305	0.992924778887147	0.890889740892024	0.230800793499915	0.863872810096492	1.09210962734814	0.742004716458102	0.647831637264308	0.765664952256522	0.789417878977268	0.731145972833119	0.712910223630664	0.405097146144926	0.752863460083084	0.842679481185684	p.Gly209Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.584	-2.47	0.886	12.108	12.108	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G209E	209	G	E	missense	wt-like	1.06986220862447	0.121482636439474	7	0.0459161206616174	0.979868265817906	1.15985615143104	0.904514275854746	1.15280613062366	1.0284157612862	NA	1.28156597315906	1.06058281834329	1.07863367084281	0.982516830261529	0.814074044829451	0.737459368599307	0.83964774841577	0.798440821955319	NA	0.858842574734665	0.814074044829451	0.868532240732032	0.787636711791507	p.Gly209Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.584	-3.38	1.796	8.772	8.772	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G209F	209	G	F	missense	possibly_low	0.644909692504334	0.37440343912987	2	0.264743210708296	0.126022534364576	1.16379685064409	NA	NA	NA	NA	0.380166481796038	NA	NA	0.90965290321263	0.636588356460492	NA	NA	NA	NA	0.522135766912672	NA	NA	0.751040946008313	p.Gly209Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.584	-3.784	2.2	11.956	11.956	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209G	209	G	G	synonymous	wt-like	1.00634323360745	0.15299703897137	8	0.0540926218790592	0.900323642895152	1.11236282431975	0.688774440107367	1.00268966333095	1.06685215644399	1.16366924213467	0.939582199069062	1.17867531539825	0.990711800653091	1.01979105172223	0.806191918718929	0.634815420568081	0.770446583387768	0.817292046603732	0.806026220342806	0.731098698679618	0.872278611519795	0.821178102357475	0.806357617095053	p.Gly209=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G209H	209	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.584	-3.672	2.088	10.278	10.278	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209I	209	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.584	-3.099	1.515	9.972	9.972	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209K	209	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.584	-2.98	1.396	7.838	7.838	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G209L	209	G	L	missense	wt-like	0.930722227714604	0.123312589238917	8	0.0435975840282547	0.845272533206266	1.01617192222294	1.10021266198742	0.728753086430564	0.876073496094692	1.02663453991248	0.923195101481995	0.901915512990146	0.836164332664636	1.0528290901549	0.736905560219452	0.83056806549995	0.644166431668468	0.723724182874485	0.745929440484483	0.72497749784594	0.735871263227609	0.737939857211295	0.822950907703815	p.Gly209Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.584	-3.192	1.608	11.554	11.554	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G209M	209	G	M	missense	possibly_low	0.550628191961568	0.616036814607127	2	0.435603809069259	-0.303139585342642	1.40439596926578	NA	NA	NA	NA	0.115024382892308	NA	NA	0.986232001030827	0.606298906184554	NA	NA	NA	NA	0.423095163277425	NA	NA	0.789502649091682	p.Gly209Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.584	-3.997	2.413	5.145	5.145	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209N	209	G	N	missense	wt-like	1.15674747931189	0.217789885337693	3	0.125741048926495	0.910299552037668	1.40319540658611	NA	NA	NA	NA	0.995381355959803	1.40447294527841	1.07038813669744	NA	0.864091250520503	NA	NA	NA	NA	0.751941794527643	0.983568096750735	0.864091250520503	NA	p.Gly209Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.584	-2.504	0.92	11.631	11.631	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G209P	209	G	P	missense	possibly_wt-like	0.818611243266609	0.212477565933233	7	0.0803089712342378	0.66120855201204	0.976013934521179	0.777129874934497	0.920583540204552	0.812467590251094	NA	0.536702960531533	0.775303989690759	0.688818213445532	1.2192725338083	0.676852861772457	0.676852861772457	0.732597042436341	0.692528509734458	NA	0.580608063122896	0.673467901156129	0.658580210932172	0.906546803873401	p.Gly209Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.584	-3.614	2.03	17.923	17.923	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209Q	209	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.584	-4.331	2.747	3.095	NA	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209R	209	G	R	missense	wt-like	0.898612574459989	0.0910266250001296	8	0.0321827719030583	0.835535500607327	0.961689648312651	1.00317615011179	0.837162941592159	0.952352549299699	0.999047516219981	0.808750297445589	0.867772153597228	0.764514787138481	0.956124200274988	0.726437021282692	0.784400371677483	0.694141550407912	0.761135432343447	0.733831108726837	0.682228034363723	0.719042933838547	0.699349885387467	0.774381064662554	p.Gly209Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.584	-3.613	2.029	22.111	22.111	87.84	0.003191692	0	0.091223876	3.231e-05	1	30946	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	neutral	neutral	medium	2.11	Deleterious	DAMAGING	effect	DAMAGING	null	N	D	D	D	D	D	0.714285714285714
G209S	209	G	S	missense	wt-like	0.901152678589447	0.214804631489744	7	0.0811885193409624	0.742026104723027	1.06027925245587	NA	1.07202246799561	1.05972004352479	0.902447219733768	0.812617298871193	1.01035000897713	0.459934584649338	0.990977126374294	0.789315664951721	NA	0.802407839497653	0.813794084260861	0.691466899821797	0.683672505675649	0.789315664951721	0.53530500072227	0.791885879075497	p.Gly209Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.584	-2.437	0.853	19.646	19.646	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.765	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
G209T	209	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.584	-2.939	1.355	9.153	9.153	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
G209V	209	G	V	missense	wt-like	0.934435385540958	0.100467501649952	7	0.0379731463156779	0.860009386382559	1.00886138469936	0.967381709075584	0.882679938590938	0.971443242057904	0.890910975535137	1.0234063811819	NA	1.0502492218792	0.754976230466048	0.762410201568115	0.767370217126755	0.715124119993364	0.770498509614385	0.686407662148753	0.762410201568115	NA	0.853244564059456	0.673354887663434	p.Gly209Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.584	-3.232	1.648	9.486	9.486	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
G209W	209	G	W	missense	possibly_wt-like	0.731435271156496	0.209086353625558	8	0.0739231892511002	0.586548482602001	0.876322059710991	1.04165609907403	0.803634899201766	0.731187358035695	0.77877507312264	0.574689176615998	0.321603761555025	0.785751551816819	0.814184249829994	0.66567505341669	0.802708227840635	0.678685687128108	0.652664419705272	0.637230289321164	0.594797351758611	0.449851449268735	0.710787866529542	0.703092000345759	p.Gly209Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.584	-5.705	4.121	0.555	NA	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G209X	209	G	X	nonsense	low	0.060180889941363	0.292619441842856	4	0.146309720921428	-0.226580893652742	0.346942673535468	0.484682073272323	NA	NA	NA	-0.186099818422757	-0.0205120313767762	NA	-0.037346663707337	0.295922900697411	0.53771306474949	NA	NA	NA	0.310613883274228	0.281231918120595	NA	0.275412253575473	p.Gly209Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	3	0	1	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G209Y	209	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly209Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	59.9	22.8	0.217	131.2	57	77	-18.8	49.4845360824742	-0.7	0	0	51.43	0	0	0	0	5	32.8847785131662	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.584	-4.599	3.015	2.773	NA	87.84	0.003191692	0	0.091223876	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210A	210	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.143	-2.859	0.716	22.425	22.425	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.805	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T210C	210	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.143	-4.172	2.029	13.671	13.671	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210D	210	T	D	missense	wt-like	1.17300223743404	0.188871315413113	5	0.0844658200527048	1.0074522722061	1.33855220266198	1.15458984619457	NA	NA	NA	0.959620546399372	1.40249480231472	1.32272830884603	1.0255776834155	0.856439452907414	0.856439452907414	NA	NA	NA	0.738583779410488	0.982593124107049	1	0.809263941619372	p.Thr210Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.143	-2.805	0.662	12.01	12.01	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T210E	210	T	E	missense	wt-like	1.11238940774377	0.183216996352573	8	0.0647769902747676	0.985428839778324	1.23934997570922	0.863624912206435	1.21185014830843	1.2273252068418	1.31827471551874	0.993574518638782	1.23240071165089	1.2051544796338	0.846910569151281	0.870347367929016	0.71800516950433	0.866866046883669	0.895996449309712	0.873828688974363	0.751266872439885	0.898758392091265	0.936675512409726	0.719528730636512	p.Thr210Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.143	-3.442	1.299	8.624	8.624	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T210F	210	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.143	-3.879	1.736	10.234	10.234	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210G	210	T	G	missense	possibly_wt-like	0.904233462755524	0.33208071377193	7	0.125514711977336	0.658229147750028	1.15023777776102	0.201646648180225	0.978373840651262	0.85970636286333	NA	1.16950746777271	1.14654680975473	1.08125460385365	0.892598506212761	0.759237398357005	0.403051455485229	0.759237398357005	0.715696882079802	NA	0.816984484066245	0.856443348518126	0.869943857934871	0.742475408252408	p.Thr210Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.143	-2.071	-0.072	18.218	18.218	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.04	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T210H	210	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.143	-4.071	1.928	10.015	10.015	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210I	210	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.143	-3.454	1.311	9.837	9.837	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.495	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T210K	210	T	K	missense	possibly_low	0.627873664533027	0.234602372227451	6	0.0957760174006237	0.440156119845123	0.815591209220931	NA	0.759638065455804	0.437504252314664	NA	0.423778536137178	0.493291293687515	0.622915973035747	1.03011386656725	0.580756109310131	NA	0.658403887218528	0.508626817358265	NA	0.53842651894933	0.534471545067506	0.623085699670933	0.811542230793379	p.Thr210Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.143	-2.803	0.66	8.457	8.457	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T210L	210	T	L	missense	possibly_wt-like	0.751380134238883	0.144000298051407	5	0.0643988910446354	0.625160627147078	0.877599641330687	0.526124898855049	0.919591895636671	0.784913326364335	0.798549848190034	NA	NA	NA	0.727720702148325	0.659665851524286	0.557430588036944	0.732139910979489	0.679014453163374	0.645902547403982	NA	NA	NA	0.659665851524286	p.Thr210Leu	0	0	NA	NA	NA	NA	NA	NA	NA	0.581	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.143	-2.884	0.741	11.834	11.834	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210M	210	T	M	missense	possibly_wt-like	0.850687253743065	0.303766329008497	6	0.124012084518202	0.607628034439651	1.09374647304648	NA	0.883310094759003	1.09612874112324	1.21658143492187	0.785153771381108	0.343985436343268	NA	0.778964043929907	0.700408665874051	NA	0.715414611381591	0.831650819648419	0.829230944038252	0.673413839278206	0.460882765527953	NA	0.685402720366511	p.Thr210Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.143	-4.983	2.84	1.731	NA	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210N	210	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.143	-2.842	0.699	27.585	27.585	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.495	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T210P	210	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.143	-3.181	1.038	16.941	16.941	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
T210Q	210	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.143	-2.867	0.724	8.918	8.918	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T210R	210	T	R	missense	low	0.433474742047111	0.272020337863626	4	0.136010168931813	0.166899709409549	0.700049774684673	0.59195490125337	NA	NA	NA	0.146239840274069	NA	0.26755181903087	0.728152407630133	0.511753137415263	0.588750957414536	NA	NA	NA	0.434755317415989	NA	0.431688914254608	0.659882674763706	p.Thr210Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.143	-3.189	1.046	11.013	11.013	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210S	210	T	S	missense	wt-like	1.26567097962683	0.146544277479102	3	0.0846073780507589	1.09984356582098	1.43149839343268	NA	NA	NA	NA	1.43417695025461	1.1680191638056	1.19481682482028	NA	0.915848547589984	NA	NA	NA	NA	0.915848547589984	0.867026485419454	0.931107719829205	NA	p.Thr210Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.143	-2.562	0.419	19.318	19.318	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	medium	2.04	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
T210V	210	T	V	missense	possibly_wt-like	0.868312315496631	0.206720967891867	4	0.103360483945933	0.665729489537971	1.07089514145529	NA	0.647397073742432	0.740250520379562	1.01035994801031	NA	NA	NA	1.07524171985423	0.69795083155832	NA	0.606662679005053	0.657109469993362	0.738792193123277	NA	NA	NA	0.834207607421791	p.Thr210Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.143	-2.606	0.463	14.697	14.697	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.04	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T210W	210	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.143	-4.253	2.11	14.293	14.293	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T210X	210	T	X	nonsense	low	0.154432991070466	0.198201898800603	4	0.0991009494003016	-0.0398013005878517	0.348667282728783	NA	0.114155203642618	0.0528519925350658	0.00644570919213462	NA	NA	NA	0.444279058912045	0.340410160260631	NA	0.36084715111454	0.319973169406721	0.298524056450359	NA	NA	NA	0.517307836945721	p.Thr210Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T210Y	210	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr210Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.4	59	23.3	0.608	68.1	-137.2	-128.5	-167.7	31.2883435582822	-6.9	0	0	46.66	0	0	0	0	8	31.8628727182594	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.143	-4.608	2.465	2.374	NA	87.84	0.002923821	0	0.083567685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C211A	211	C	A	missense	wt-like	0.805663318092486	0.108436270061202	7	0.0409850576687686	0.725334081157402	0.885992555027569	0.848514915399128	NA	0.898186623460683	0.73134480638744	0.975207754089479	0.789468253196671	0.662142575958496	0.734778298155502	0.680449079811923	0.71081618782337	NA	0.734569620641058	0.616429672744604	0.744406191109721	0.680449079811923	0.644212888830574	0.663210515405739	p.Cys211Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.077	-2.636	0.559	12.003	12.003	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.55	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
C211C	211	C	C	synonymous	wt-like	1.1304101479168	0.163708409955901	5	0.0732126266299595	0.986916036508499	1.2739042593251	1.02654779087729	1.30452187437106	0.934803908806232	1.29303986663221	NA	NA	NA	1.0931372988972	0.843195627224398	0.795520049560932	0.909586152974261	0.752528658402798	0.862761907103059	NA	NA	NA	0.843195627224398	p.Cys211=	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	NA	NA	NA	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
C211D	211	C	D	missense	possibly_low	0.662831968110162	0.184589439246991	4	0.0922947196234954	0.481937641684889	0.843726294535435	NA	NA	0.74073519319608	0.850841562011976	NA	0.417073852699137	NA	0.642677264533455	0.637150064597095	NA	NA	0.657347178969649	0.668835159092927	NA	0.496906049903905	NA	0.616952950224541	p.Cys211Asp	0	1	NA	NA	NA	NA	NA	NA	NA	6.911	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.077	-3.631	1.554	10.632	10.632	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C211E	211	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.077	-3.6	1.523	8.772	8.772	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C211F	211	C	F	missense	wt-like	1.00490140416082	0.218187514235272	5	0.0975764227343544	0.813655129861228	1.19614767846041	1.05120561948111	0.830930530598344	0.924371931366639	NA	1.36380862354752	NA	NA	0.85419031581047	0.747412269380529	0.807251665416696	0.691268513828492	0.747412269380529	NA	0.889563315698527	NA	NA	0.723184969251291	p.Cys211Phe	1	1	NA	NA	NA	NA	NA	NA	NA	1.215	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.077	-3.257	1.18	24.772	24.772	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.405	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C211G	211	C	G	missense	possibly_low	0.58080582220684	0.234404520646212	8	0.0828745130448593	0.418374761402621	0.74323688301106	0.764836364819794	0.507778724493466	0.579828886420371	0.734818914423038	0.520491815714671	0.0756059046076475	0.638298544773823	0.824787422401912	0.59819176639212	0.671003898325519	0.542300969716523	0.578430284606307	0.617953248177933	0.574552587304764	0.328605823784901	0.631370651174689	0.708417423167676	p.Cys211Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.077	-2.356	0.279	23.026	23.026	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.295	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
C211H	211	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.077	-5.14	3.063	1.345	NA	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C211I	211	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.077	-2.79	0.713	14.423	9.568	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.55	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
C211K	211	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.077	-3.258	1.181	8.457	8.457	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C211L	211	C	L	missense	possibly_wt-like	0.737385626341828	0.116658138297735	8	0.0412448803354632	0.656547146337656	0.818224106346	0.679397158755561	0.605950662465799	0.837400079381278	0.918055030631876	0.850304766530666	0.709475468945477	0.68743829381709	0.611063550206878	0.649429908198171	0.630353930290151	0.587556580931348	0.704756710420492	0.698311729346023	0.697750200473687	0.641022821058766	0.657836995337576	0.601075023630551	p.Cys211Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.077	-2.528	0.451	18.729	18.729	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
C211M	211	C	M	missense	possibly_low	0.548408654785186	0.246229873730458	5	0.110117347150499	0.332582620297114	0.764234689273258	NA	0.295540348627416	0.943527764129202	NA	0.577219714393692	0.403742478253492	NA	0.522012968522127	0.556349542007726	NA	0.444462650320538	0.756807294727001	NA	0.595742603342803	0.490335379519703	NA	0.556349542007726	p.Cys211Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.077	-3.783	1.706	4.743	4.743	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C211N	211	C	N	missense	possibly_low	0.312975414061396	0.522928563386296	2	0.369766333246589	-0.411753281797353	1.03770410992015	NA	NA	NA	-0.0567909191851927	NA	NA	NA	0.682741747307985	0.453933397233078	NA	NA	NA	0.270791535614775	NA	NA	NA	0.637075258851381	p.Cys211Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.077	-3.331	1.254	9.431	9.431	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C211P	211	C	P	missense	possibly_wt-like	0.744171503635572	0.0337604979995654	3	0.0194916326080249	0.705968605723956	0.782374401547187	NA	NA	NA	NA	0.751688887128566	0.707285965763264	0.773539658014884	NA	0.660913439112939	NA	NA	NA	NA	0.660913439112939	0.639943674735622	0.704210621213167	NA	p.Cys211Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.077	-4.437	2.36	1.5	NA	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C211Q	211	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.077	-3.834	1.757	5.255	5.255	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C211R	211	C	R	missense	low	0.45688306324902	0.0898307670140511	8	0.0317599722574122	0.394634661474501	0.51913146502354	0.476569977486119	0.519380714185317	0.332165593674713	0.517512964282143	0.602228178265891	0.367528838832126	0.44338817946144	0.396290059804414	0.524523302521153	0.533853520055674	0.547649291708096	0.456963212849258	0.522653388830288	0.605084210609751	0.472486665644001	0.526393216212018	0.493205455388188	p.Cys211Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.077	-3.39	1.313	10.5	10.5	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C211S	211	C	S	missense	possibly_low	0.635804890219984	0.203090212863796	6	0.0829112322115867	0.473301861171437	0.798307919268531	NA	0.337642092029305	0.67127363635695	0.4605192945758	0.667176132706933	NA	0.809999866296059	0.868218319354855	0.626312157900172	NA	0.463870845475035	0.623279587380291	0.497658727141554	0.629344728420055	NA	0.723847848496735	0.730230506774566	p.Cys211Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.077	-2.417	0.34	7.64	7.64	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
C211T	211	C	T	missense	possibly_low	0.511030848971937	0.396056430094544	5	0.177121820123459	0.163878460653776	0.858183237290098	1.01807072619284	0.618830678801537	0.453024086797654	0.549107894765839	NA	-0.0838791416981843	NA	NA	0.536509394288227	0.791486861235217	0.593494051697129	0.516238558395476	0.536509394288227	NA	0.25	NA	NA	p.Cys211Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.077	-2.79	0.713	10.251	10.251	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
C211V	211	C	V	missense	possibly_wt-like	0.791159456292315	0.17704420934898	8	0.0625945805002374	0.668476332884457	0.913842579700173	1.12098859641204	0.890310228249754	0.681094562416313	0.916962345044287	0.791557506783759	0.678955809115633	0.575465818150014	0.673940784166724	0.654230434451713	0.840452767256548	0.718641555111668	0.628096284748513	0.697832530397532	0.675805876689169	0.625980514221049	0.597529359757956	0.632654992214256	p.Cys211Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.077	-2.877	0.8	23.649	23.649	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.1	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
C211W	211	C	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Trp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.077	-3.474	1.397	13.184	13.184	87.84	0.00283035	0	0.080896108	0	NA	NA	not provided	Pathogenic(Last reviewed: Jun 15, 2016)	criteria provided, single submitter	1	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.1	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C211X	211	C	X	nonsense	low	-0.0621686456543476	0.0422821614016474	7	0.0159811548518647	-0.09349113359536	-0.0308461577133352	-0.0950620609329137	-0.0206375981483624	-0.053692260644634	-0.0696921943414796	-0.136892992741502	-0.0361778131066459	-0.0230255996648954	NA	0.273510682138699	0.261884418748059	0.298709937992306	0.267718278087117	0.265133661511456	0.328994494043306	0.273510682138699	0.275185836422565	NA	p.Cys211Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	4.101e-06	1	243844	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C211Y	211	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys211Tyr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	24.8	60	22.2	0.917	18.1	-130.3	-148.1	168.6	4.05405405405405	-0.5	0	0	29.85	0	0	0	0	7	29.6997147774183	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.077	-3.605	1.528	9.057	9.057	87.84	0.00283035	0	0.080896108	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N212A	212	N	A	missense	possibly_low	0.544443398838423	0.528919862274299	5	0.236540153339032	0.0808332173963388	1.00805358028051	NA	0.927711181446582	0.546297514120545	0.64640543783342	-0.348369550675429	NA	NA	0.950172411466996	0.579179381756126	NA	0.735882765093859	0.561984740496393	0.579179381756126	0.25	NA	NA	0.77139179029827	p.Asn212Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.366	-2.956	0.59	14.447	14.447	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.95	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N212C	212	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.366	-3.363	0.997	35.138	35.138	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N212D	212	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Asp	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.366	-2.485	0.119	35.538	35.538	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.145	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	.	B	0.214285714285714
N212E	212	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Glu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.366	-2.762	0.396	10.762	10.762	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.495	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N212F	212	N	F	missense	wt-like	0.93169285937833	0.125691001806901	2	0.0888769597117901	0.757497219287804	1.10588849946886	1.02056981909012	NA	NA	NA	NA	NA	NA	0.84281589966654	0.755074030899038	0.792675870954191	NA	NA	NA	NA	NA	NA	0.717472190843884	p.Asn212Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.366	-4.627	2.261	10.167	NA	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N212G	212	N	G	missense	low	0.562152174371083	0.147716757778495	8	0.0522257605600321	0.459791564608207	0.664512784133958	0.72107035206781	0.61974347574226	0.667817783575989	0.650814267360303	0.272363805072085	0.582871255921155	0.418165205565633	0.564371249663426	0.57986797138114	0.650181057134016	0.593914835724832	0.621584655874402	0.581112880740058	0.481867389237528	0.578623062022222	0.512808289122744	0.577623906407347	p.Asn212Gly	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.366	-3.029	0.663	19.989	19.989	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N212H	212	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212His	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.366	-3.466	1.1	14.232	14.232	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	.	D	0.714285714285714
N212I	212	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Ile	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.366	-3.276	0.91	8.692	8.692	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
N212K	212	N	K	missense	low	0.393929674982412	0.183218980209313	3	0.105781527544496	0.186601690765569	0.601257659199255	NA	NA	0.564695003631369	0.200386959772678	NA	NA	NA	0.416707061543189	0.503459854840552	NA	NA	0.571007834527754	0.383577290795984	NA	NA	NA	0.503459854840552	p.Asn212Lys	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.366	-2.484	0.118	17.807	17.807	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.6	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
N212L	212	N	L	missense	possibly_wt-like	0.723161855485367	0.215643702442212	7	0.0815056583513293	0.563413700580535	0.882910010390199	0.843375233073548	0.6301367913266	0.761354322901407	0.750644821368658	0.975372658890134	0.29513893522994	NA	0.806110225607281	0.667459881904827	0.708370847658461	0.598705979294296	0.667459881904827	0.624893724059926	0.744467789290721	0.436807659127944	NA	0.699036837368008	p.Asn212Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.366	-3.086	0.72	13.697	13.697	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N212M	212	N	M	missense	wt-like	1.0217613982211	0.0156778981839807	2	0.011085948120645	1.00003333917015	1.04348945727204	NA	NA	1.03284734634174	1.01067545010045	NA	NA	NA	NA	0.76977243040451	NA	NA	0.800614303757855	0.738930557051165	NA	NA	NA	NA	p.Asn212Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.366	-4.153	1.787	4.783	4.783	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N212P	212	N	P	missense	low	0.245966039323495	0.151178943618873	4	0.0755894718094367	0.0978133969665934	0.394118681680397	0.0743574624696405	0.417745811679848	0.31518920900682	NA	NA	NA	NA	0.176571674137672	0.415744713147395	0.342490249819376	0.500797312123661	0.448637103187347	NA	NA	NA	NA	0.382852323107444	p.Asn212Pro	0	1	NA	NA	NA	NA	NA	NA	NA	11.774	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.366	-3.111	0.745	20.501	20.501	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.95	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N212Q	212	N	Q	missense	wt-like	0.8621632414065	0.211688603687286	8	0.0748432235835959	0.715473218695773	1.00885326411723	0.536799110513534	1.08373650408476	1.04676392642712	0.84554352625534	0.549893087647362	1.00639310563564	0.932349836445145	0.895826834243101	0.765731122545344	0.562509127301389	0.807807812992689	0.807439724728009	0.666511697346487	0.585535074551782	0.787365415357794	0.789744734039099	0.744096829732894	p.Asn212Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.366	-3.276	0.91	7.644	7.644	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N212R	212	N	R	missense	possibly_wt-like	0.759918559277348	0.135036293655645	8	0.0477425394751022	0.666344901375666	0.85349221717903	0.787961673284267	0.590075252699037	0.844336247098677	0.882779647627182	0.803455655249431	0.65077236066721	0.583942820396721	0.936024817196259	0.681128331152021	0.6820063770843	0.580238284205016	0.708158570956657	0.682841655762663	0.680250285219743	0.612089662171263	0.602095017159531	0.764286188565054	p.Asn212Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.366	-2.643	0.277	29.879	29.879	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.95	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N212S	212	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Ser	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.366	-2.469	0.103	12.06	12.06	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.405	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N212T	212	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.366	-2.788	0.422	12.631	12.631	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.605	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N212V	212	N	V	missense	possibly_wt-like	0.854929841364556	0.252067721666586	7	0.0952726435823476	0.668198891231234	1.04166079149788	0.901089075016077	1.07339965101679	0.9276620786796	1.06505580375063	0.786563449342848	0.330348514568077	NA	0.900390317177865	0.746388830169875	0.73582973846789	0.803042697693035	0.749025930231615	0.76277914495581	0.673940407321679	0.454161499209519	NA	0.746388830169875	p.Asn212Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.366	-3.14	0.774	10.555	10.555	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
N212W	212	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn212Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.366	-5.811	3.445	2.128	NA	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N212X	212	N	X	nonsense	low	0.205481428360553	0.439273975098445	3	0.253614947771084	-0.291594735211779	0.702557591932884	NA	NA	NA	NA	0.712361190738854	-0.0642773090163617	NA	-0.0316395966408334	0.278278616920597	NA	NA	NA	NA	0.646223056838206	0.259661208002497	NA	0.278278616920597	p.Asn212Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N212Y	212	N	Y	missense	wt-like	1.16792659804391	0.15007051011908	5	0.0671135724088664	1.03638641324871	1.29946678283911	NA	1.02958258520954	1.03152983177054	1.27083414646723	1.37000731108079	NA	1.13767911569147	NA	0.853023554301105	NA	0.782843767777784	0.799968125492246	0.853023554301105	0.891878759973803	NA	0.900333727207664	NA	p.Asn212Tyr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	28.2	58.6	21.1	0.687	44.1	-158.9	-122.9	71.2	37.9679144385027	-3.1	0	0	34.92	0	0	0	0	6	30.1734469005449	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.366	-3.531	1.165	24.573	24.573	58.31	0.003067714	0	0.087680362	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	.	B	0.5
P213A	213	P	A	missense	possibly_low	0.53835037390682	0.289260402251514	7	0.109330155499431	0.324067206703772	0.752633541109868	0.609486346039007	0.523496366445595	0.357016929371277	0.238651945091542	0.318141030073659	1.10328532969995	NA	0.618374670626709	0.549546538135472	0.597092007185225	0.549546538135472	0.469151611633946	0.400358459081818	0.498966914419113	0.835120946470856	NA	0.604747019655653	p.Pro213Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.837	-3.079	1.242	21.06	21.06	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.32	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.5
P213C	213	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.837	-3.825	1.988	19.428	19.428	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P213D	213	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.837	-2.939	1.102	12.108	12.108	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P213E	213	P	E	missense	low	0.249163686224506	0.139623363605461	8	0.0493643136087484	0.152411409429818	0.345915963019193	0.406632928954542	0.185066595527468	0.243220849908914	0.485411806748398	0.224747458126898	0.187781072674828	0.032622636557307	0.227826141297691	0.410967411953478	0.500579114566007	0.393536109366005	0.413340044257585	0.508575376719349	0.464080882440398	0.383893900619525	0.305157608777724	0.408594779649372	p.Pro213Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.837	-3.472	1.635	14.816	14.816	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P213F	213	P	F	missense	possibly_wt-like	0.800780821518067	0.568824364952678	4	0.284412182476339	0.243343187100009	1.35821845593612	1.33312569333367	0.887396786739562	NA	NA	NA	-0.00278148678141647	NA	0.985382292780453	0.753187196190675	0.9413826167509	0.717298507607406	NA	NA	NA	0.289970819330182	NA	0.789075884773944	p.Pro213Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.837	-3.229	1.392	10.904	10.904	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P213G	213	P	G	missense	low	0.315500458156065	0.157097149031355	8	0.0555422296925725	0.206639688337571	0.424361227974558	0.283996668659175	0.244047171016071	0.46282333550876	0.43496113005008	0.0702925420674472	0.549452487958504	0.193475193125739	0.284955136862742	0.439759684112518	0.44223166155672	0.420725162049177	0.521044624054869	0.486450154698388	0.406386128630239	0.562151863960536	0.391791732974654	0.437287706668317	p.Pro213Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.837	-2.504	0.667	15.941	15.941	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P213H	213	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.837	-3.77	1.933	11.333	11.333	49.88	0.002814372	0	0.080439442	3.229e-05	1	30968	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P213I	213	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.837	-2.805	0.968	11.319	11.319	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P213K	213	P	K	missense	low	0.226498970041135	0.021736126492249	3	0.0125493584814397	0.201902679388431	0.251095260693839	NA	0.201523109141703	NA	NA	NA	0.241134916816727	NA	0.236838884164974	0.410190553302704	NA	0.401122285186301	NA	NA	NA	0.410190553302704	NA	0.413121412242396	p.Pro213Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.837	-2.583	0.746	10.107	10.107	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P213L	213	P	L	missense	possibly_wt-like	0.7383909669019	0.227311203330513	8	0.0803666466573398	0.580875233895257	0.895906699908542	0.470350738669089	0.911215262446914	0.951027342978442	1.10474485003005	0.566179291321514	0.526543387837339	0.711355341274396	0.665711520657449	0.64962020984097	0.530894552261351	0.728278424054053	0.760485481640085	0.780184837370668	0.59161858769241	0.550860594158716	0.670718559075474	0.628521860606465	p.Pro213Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.837	-2.245	0.408	15.282	15.282	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.815	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P213M	213	P	M	missense	possibly_wt-like	0.826718229285811	0.252673881266522	8	0.0893337074361413	0.651627380105536	1.00180907846609	0.293795087619893	0.903649135315348	0.979131025731926	0.951655686309205	0.99714794730302	0.625899945526734	0.81520978335596	1.0472572231244	0.725722221091839	0.446893519220178	0.724790566780984	0.774269002047207	0.713047348678867	0.752601683220281	0.59983072801459	0.726653875402693	0.820152448314077	p.Pro213Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.837	-3.525	1.688	4.984	4.984	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P213N	213	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.837	-4.242	2.405	2.117	NA	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P213P	213	P	P	synonymous	possibly_low	0.696274259002318	0.451190122690761	3	0.260494738791211	0.185713952809375	1.20683456519526	NA	NA	0.215779295670961	NA	NA	NA	1.11092348800329	0.762119993332706	0.676942828682636	NA	NA	0.399881266411287	NA	NA	NA	0.885923322912231	0.676942828682636	p.Pro213=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P213Q	213	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.837	-3.363	1.526	7.75	7.75	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P213R	213	P	R	missense	low	0.375717556444486	0.260252230965572	7	0.098366097326378	0.182923548385023	0.568511564503948	0.341777972407788	0.350074960536954	0.391323778254189	0.423550257319381	0.89041122552843	0.079771210537453	NA	0.153113490527206	0.469722649109403	0.469722649109403	0.469602188617367	0.485977490143517	0.481445898875828	0.712731480041264	0.330658789323128	NA	0.371070495969145	p.Pro213Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.837	-3.682	1.845	10.159	10.159	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.32	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P213S	213	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.837	-3.432	1.595	6.125	5.457	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P213T	213	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.837	-3.467	1.63	7.261	7.261	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P213V	213	P	V	missense	wt-like	0.903194240306509	0.134875559292244	3	0.0778704404644786	0.750570981535861	1.05581749907716	NA	1.05715497019028	0.805879502135064	NA	NA	NA	NA	0.846548248594188	0.719346755840713	NA	0.795554173222825	0.689297365695872	NA	NA	NA	NA	0.719346755840713	p.Pro213Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.837	-2.642	0.805	12.159	12.159	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P213W	213	P	W	missense	possibly_low	0.624284995331365	0.445537564834456	4	0.222768782417228	0.18766620491376	1.06090378574897	NA	1.00514021645057	NA	NA	0.0564253081324895	0.95285158771733	NA	0.482722869025069	0.64879621463647	NA	0.771576247134187	NA	NA	0.401206192191069	0.760976263395597	NA	0.536616165877343	p.Pro213Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.837	-5.694	3.857	1.078	NA	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P213X	213	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro213Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P213Y	213	P	Y	missense	wt-like	1.01907312703854	0.0882118719487384	4	0.0441059359743692	0.932627081024351	1.10551917305274	NA	1.10449459089287	1.04175745884817	1.03462326841237	NA	NA	NA	0.895417190000769	0.777208600028351	NA	0.817376941661784	0.804984290376311	0.749432909680391	NA	NA	NA	0.743891086708135	p.Pro213Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.4	60.7	23.5	0.078	19.9	173.3	-58.2	148.6	0.649350649350649	-3.7	0	1	28.58	0	0	0	0	8	27.4619642025111	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.837	-3.8	1.963	12.444	12.444	49.88	0.002814372	0	0.080439442	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q214A	214	Q	A	missense	wt-like	1.12009914286534	0.117387584300603	8	0.0415027784430321	1.03875519185865	1.20144309387202	1.24400747096206	1.20517573225482	1.17154580669041	1.20689180960392	1.18367250231737	0.942747259133034	1.02510383163348	0.981648730327593	0.832341483466434	0.898982259143982	0.863789253410436	0.868639305157904	0.82498154392135	0.822275660298227	0.755996115785778	0.839701423011517	0.787200710286435	p.Gln214Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.544	-2.975	0.431	21.06	21.06	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.86	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q214C	214	Q	C	missense	possibly_wt-like	0.913855397661383	0.356710166933514	7	0.134823770262059	0.649605663687845	1.17810513163492	1.16398019692748	1.1325381437113	1.10593252848418	1.04535316905133	0.31173219611783	NA	0.488399139131736	1.14905241020582	0.830304547550451	0.860907161289988	0.830304547550451	0.836459111299803	0.754138524142602	0.496572972505671	NA	0.550635821697995	0.871278883234172	p.Gln214Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.544	-3.976	1.432	24.824	24.824	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.86	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q214D	214	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.544	-3.451	0.907	16.44	16.44	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.405	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q214E	214	Q	E	missense	possibly_wt-like	0.938767681321246	0.556647282331143	6	0.227250301403045	0.493365275095407	1.38417008754709	1.23141565967806	1.11660447085371	1.12017911152768	1.22616039369791	-0.192456593317235	NA	NA	1.13070304548735	0.83843909710299	0.892991371005147	0.822959392519788	0.843446383033342	0.833431811172639	0.308239387389472	NA	NA	0.862062950457765	p.Gln214Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.544	-2.868	0.324	11.794	11.794	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.75	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Q214F	214	Q	F	missense	wt-like	0.872773301811884	0.157144528148174	8	0.055558980739967	0.763879700543794	0.981666903079973	0.629240688804558	0.929053135729058	0.889339616864016	0.716111197684375	1.16431961960037	0.892790589827522	0.885317576544519	0.87601398944065	0.732759852365227	0.606490659618578	0.736501383433581	0.730230584471431	0.609748950169737	0.815046626529924	0.731373837802553	0.764413469604022	0.734145866927902	p.Gln214Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.544	-2.538	-0.006	19.703	19.703	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q214G	214	Q	G	missense	wt-like	0.915637358819161	0.118216720221323	8	0.0417959222590652	0.833718856490758	0.997555861147565	0.960657773598599	0.952627428971805	0.995212338441406	0.932394756525862	0.909755701786635	0.630418202299973	0.965830832948344	0.978201835980667	0.755769931193004	0.764171126512479	0.747368735873529	0.782156121463147	0.704600438237311	0.719957373679211	0.602057653384452	0.807777377543034	0.785469514298126	p.Gln214Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.544	-3.083	0.539	18.851	18.851	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.75	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q214H	214	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.544	-3.476	0.932	30.835	30.835	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	D	D	B	0.571428571428571
Q214I	214	Q	I	missense	possibly_wt-like	0.944214369734673	0.376081111886072	5	0.168188586246192	0.614570798081427	1.27385794138792	NA	0.959092417181394	1.17514507382083	1.15994014739661	1.13721177598473	0.289682434289803	NA	NA	0.804390820098127	NA	0.750348986635249	0.870404574584616	0.804390820098127	0.804920821514261	0.434118298831681	NA	NA	p.Gln214Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.544	-3.688	1.144	10.423	8.287	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q214K	214	Q	K	missense	possibly_low	0.533067289945733	0.165535208973973	2	0.117051068790628	0.303651410764181	0.762483169127285	NA	0.416016221155105	NA	NA	NA	NA	0.650118358736362	NA	0.56886836244004	NA	0.5	NA	NA	NA	NA	0.63773672488008	NA	p.Gln214Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.544	-2.514	-0.03	10.107	10.107	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.06	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
Q214L	214	Q	L	missense	wt-like	0.894644266610726	0.218480666397188	8	0.0772445803838037	0.743247671057561	1.04604086216389	0.815974475960627	0.955792638412483	0.720020127320722	0.491184913595621	0.885914952669727	1.1737344855802	1.06343592225733	1.05109661708909	0.729939898100919	0.695334210825159	0.748827844156603	0.647187423903653	0.511107181624749	0.711051952045235	0.869843411436624	0.860346833757118	0.822080776472766	p.Gln214Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.544	-2.933	0.389	34.011	34.011	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
Q214M	214	Q	M	missense	wt-like	1.12999406529416	0.122243041128479	2	0.0864388833348136	0.960576967094068	1.29941116349426	NA	NA	NA	NA	1.21643294862898	NA	1.04355518195935	NA	0.84207606231612	NA	NA	NA	NA	0.834512926245344	NA	0.849639198386896	NA	p.Gln214Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.544	-3.676	1.132	13.866	13.866	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.405	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q214N	214	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.544	-3.233	0.689	11.553	11.553	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q214P	214	Q	P	missense	low	0.202588994765777	0.203368092235889	8	0.0719014785484843	0.0616646863755682	0.343513303155985	0.351182685204412	0.229167583296119	0.493788131262096	0.313549910060891	-0.0540791326769089	0.00268565309947093	-0.0258432614653706	0.310260389345503	0.423535499789769	0.474197190624655	0.413865922527178	0.536231384377786	0.433205077052361	0.359928603428705	0.292665423269791	0.273668262393436	0.449997220558808	p.Gln214Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.544	-3.812	1.268	13.013	13.013	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Q214R	214	Q	R	missense	possibly_wt-like	0.889629744062482	0.265360656763534	8	0.0938191599288054	0.70574756954222	1.07351191858274	0.498224859047554	0.807174084337873	0.916063289457447	0.885518391011734	1.27281180212059	0.800153187041356	1.25569721306872	0.681395126414589	0.684879063896588	0.544156404221291	0.680317191912928	0.743337275497507	0.684042735894928	0.855572560702336	0.685715391898249	0.963897494696282	0.636398921124204	p.Gln214Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.544	-2.98	0.436	17.159	17.159	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.205	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
Q214S	214	Q	S	missense	wt-like	1.00975267248967	0.236357493330075	6	0.0964925425903272	0.820630764235928	1.19887458074341	1.31909771844997	1.11149844262195	0.82223511824633	0.68664602152817	NA	1.17944345813541	NA	0.939595275956162	0.793342521988423	0.934708435694087	0.820605599437154	0.697319017890645	0.59682695175451	NA	0.872657208096952	NA	0.766079444539692	p.Gln214Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.544	-2.507	-0.037	8.568	8.568	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.405	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q214T	214	Q	T	missense	wt-like	1.14427964819823	0.0591550102278549	6	0.0241499317978941	1.09694665164526	1.1916126447512	NA	1.10429672597671	1.13997451594306	1.19459341314448	1.23311738348045	NA	1.07498182005539	1.1187140305893	0.846950140833309	NA	0.817285729265412	0.853155087871776	0.819588063199696	0.840745193794841	NA	0.866565378026112	0.85604149102029	p.Gln214Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.544	-2.887	0.343	9.885	9.885	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q214V	214	Q	V	missense	wt-like	0.988505010720138	0.214567439377917	8	0.0758610457029792	0.839820093312752	1.13718992812752	1.23264969748893	0.777802493477395	1.13121345330423	1.12154818746817	0.635755229533867	0.811305535509333	1.10080454161994	1.09696094735923	0.816335007068271	0.89357849721894	0.666777382837168	0.848858203127896	0.78755396690157	0.617607832506913	0.691212079887294	0.880473325247173	0.845116047234973	p.Gln214Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.544	-2.886	0.342	9.954	9.954	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q214W	214	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.544	-4.289	1.745	16.51	16.51	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q214X	214	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	4	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q214Y	214	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln214Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.1	61.3	23	0.973	10.6	-167	-152	143.1	4.67289719626168	-5.2	0	1	23.09	1	13	0	0	7	26.5083831619358	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.544	-2.601	0.057	17.327	17.327	90.57	0.002992887	0	0.085541702	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.95	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
F215A	215	F	A	missense	low	0.45489890055196	0.199630729888795	7	0.0754533236188657	0.307013103745138	0.602784697358782	0.65268975480673	0.597012425532805	0.455367743887388	0.33922576816837	0.574083398010622	0.0672214087754425	NA	0.498691804682361	0.544636532783027	0.6176471746116	0.583436204131824	0.517388010786004	0.444465264197196	0.59457107053434	0.324473334769926	NA	0.544636532783027	p.Phe215Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.076	-3.267	1.191	10.494	10.494	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215C	215	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe215Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.076	-3.618	1.542	19.548	19.548	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.61	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F215D	215	F	D	missense	low	0.0781090341662568	0.22379132811935	5	0.100082524489965	-0.118049109315923	0.274267177648437	NA	0.0184170634716176	NA	NA	-0.190095057193872	0.041874230562503	0.0910220748706153	0.42932685912042	0.316713479726386	NA	0.316713479726386	NA	NA	0.309121510462841	0.311980402860623	0.336611160401653	0.509798123653016	p.Phe215Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.076	-3.151	1.075	28.844	28.844	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.065	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F215E	215	F	E	missense	low	0.266725857853854	0.116457363822852	8	0.0411738958391239	0.186026504905967	0.34742521080174	0.219465464751244	0.392844219890193	0.372228077947694	0.397748987114464	0.180520920158277	0.143824651136949	0.112801256171916	0.314373285660093	0.449811756132867	0.411529230003586	0.489318097391437	0.47661195690819	0.470130712062375	0.447560597524422	0.362228980894101	0.348341283553047	0.452062914741312	p.Phe215Glu	0	0	NA	NA	NA	NA	NA	NA	NA	14.305	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.076	-3.108	1.032	8.624	8.624	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215G	215	F	G	missense	low	0.223427119748416	0.147960951796654	8	0.0523120961831148	0.120897295273716	0.325956944223116	0.248451577171041	0.247929581208822	0.309748604468031	0.473996126968502	-0.0141337641405269	0.153358570535798	0.0909317486583619	0.277134513117298	0.423917514737367	0.42532014166595	0.422514887808784	0.445968745294708	0.503569012757956	0.374849709615287	0.366927989394298	0.336562511300529	0.433359813587908	p.Phe215Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.076	-3.521	1.445	14.549	14.549	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215H	215	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe215His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.076	-4.057	1.981	9.751	9.751	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215I	215	F	I	missense	wt-like	0.983278629704393	0.18900649830041	7	0.0714377415254338	0.843263229177661	1.12329403023112	NA	1.12711198937912	0.985038822951955	1.0456684958558	0.746635591711714	1.14282230147816	0.694523279575289	1.14114992697872	0.777166495740744	NA	0.8278031817231	0.777166495740744	0.754276811198683	0.659025842120603	0.854607640104986	0.661652921855649	0.867309876388154	p.Phe215Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.076	-2.338	0.262	10.915	10.915	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.41	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F215K	215	F	K	missense	low	0.251592242172692	0.131618218366391	8	0.0465340673672835	0.160387146078656	0.342797338266729	0.316202458140431	0.245201439886644	0.361988346918592	0.464468463320196	0.0528220879114415	0.265489677444259	0.137277303940008	0.169288159819968	0.421725805129888	0.457554419963236	0.421257260572675	0.471589855611321	0.499390641180893	0.399860253137261	0.422194349687101	0.361523921164957	0.379194192193496	p.Phe215Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.076	-2.982	0.906	8.457	8.457	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215L	215	F	L	missense	possibly_wt-like	0.860567221928246	0.239227780380603	7	0.0904196019407218	0.683348058627983	1.03778638522851	NA	0.643535983605204	0.718026221634301	0.757700225726897	1.32412666875276	0.865142905532865	1.01654772264601	0.698890825599676	0.646209507950084	NA	0.604882781432235	0.646209507950084	0.627987882515067	0.874740604508757	0.71774704927243	0.835093159242038	0.645186102045168	p.Phe215Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.076	-2.148	0.072	15.654	15.654	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.265	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F215M	215	F	M	missense	possibly_wt-like	0.78304766651676	0.170403091132977	8	0.0602465906376388	0.66496651867566	0.901128814357861	0.905228255854148	0.833427198866449	0.582802280080582	0.608789706854212	1.0449084618204	0.590266293519021	0.829882113124768	0.869077022014506	0.711540612199574	0.737799063517958	0.692419435882263	0.579888592848448	0.562682944961583	0.770442042059142	0.582267874095612	0.73455629527445	0.730661788516886	p.Phe215Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.076	-3.195	1.119	5.989	5.989	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215N	215	F	N	missense	low	0.227666935823912	0.176157821128203	4	0.0880789105641015	0.0550354433207488	0.400298428327076	NA	NA	NA	NA	0.189761126067003	0.0510340587189391	0.471766988647866	0.198105569861841	0.422339922180071	NA	NA	NA	NA	0.451012163966334	0.316495032003873	0.541677855337861	0.393667680393808	p.Phe215Asn	0	0	NA	NA	NA	NA	NA	NA	NA	10.499	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.076	-3.735	1.659	9.981	9.981	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215P	215	F	P	missense	low	0.329315924640028	0.0606823561061472	8	0.0214544527505168	0.287265969940998	0.371365879339057	0.324485736039407	0.240949077311758	0.285297750892649	0.372023350633149	0.352342260996303	0.365985826398352	0.270229644238719	0.423213750609886	0.460172051810866	0.461495409086757	0.419296992991039	0.433976763952475	0.458848694534975	0.511742367919905	0.471726156955088	0.433131173218864	0.50672782678158	p.Phe215Pro	0	0	NA	NA	NA	NA	NA	NA	NA	11.316	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.076	-3.783	1.707	14.977	14.977	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215Q	215	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe215Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.076	-3.419	1.343	6.529	6.529	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215R	215	F	R	missense	low	0.232188504267562	0.167110475253109	8	0.0590824751293902	0.116388980896474	0.34798802763865	0.303529812006377	0.284383754423289	0.363020983166368	0.432731046237647	-0.0284464165581013	-0.00217122038159677	0.194460525932471	0.309999549314039	0.444592931156411	0.451525072500836	0.439319648152995	0.472096314601739	0.485472148005426	0.369503392523738	0.290271602972268	0.392322426714156	0.449866214159826	p.Phe215Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.076	-3.751	1.675	9.647	9.647	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215S	215	F	S	missense	low	0.359348687114536	0.208712249284887	8	0.0737909233930203	0.214721134878262	0.50397623935081	0.577057687546781	0.404350167165292	0.453221212568327	0.560653032131704	-0.0855372344298476	0.288500721901569	0.304092912153922	0.372450997878544	0.487927239150638	0.581663212936507	0.49462214544524	0.516335239215092	0.541572532073468	0.348177812438847	0.433535865068105	0.451369705579595	0.481232332856037	p.Phe215Ser	1	0	NA	NA	NA	NA	NA	NA	NA	11.399	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.076	-3.509	1.433	5.785	5.785	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	2	1	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F215T	215	F	T	missense	low	0.350375353388163	0.160277007771775	8	0.0566664795318554	0.23931109437505	0.461439612401276	0.29545527837828	0.418525198990906	0.460954402014841	0.486684139331373	0.0302429427555287	0.222544503863983	0.493715413957489	0.394880947812906	0.49682716409286	0.447683398999846	0.501156596557314	0.520128001020836	0.50913336013454	0.391426088306192	0.401027846462781	0.553499132193924	0.492497731628407	p.Phe215Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.076	-3.499	1.423	5.675	5.675	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215V	215	F	V	missense	wt-like	0.971247210379063	0.0801401204741814	8	0.0283338113162003	0.915713960654557	1.02678046010357	1.14247647445453	0.893952499789941	0.902465641284845	0.979710731279324	0.99448717259185	0.92889042273375	0.929203045394331	0.998791695503931	0.750387121384942	0.850676195069287	0.720320580993871	0.736668275469292	0.725350931889132	0.751607783214884	0.749166459555001	0.788049893170331	0.795810731236881	p.Phe215Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.076	-2.276	0.2	10.489	10.489	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.41	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F215W	215	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe215Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.076	-5.459	3.383	1.146	NA	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F215X	215	F	X	nonsense	low	0.0821428171781132	0.236046755094241	7	0.0892172873947329	-0.0927198529139225	0.257005487270149	-0.026169530946478	-0.0414977019866162	0.0143485190607996	0.00560138463935983	0.613019859181382	0.0439382089293975	NA	-0.0342410186310524	0.298153776616461	0.294661866840435	0.289093781189219	0.301089046032825	0.298153776616461	0.609115311655297	0.312997681430382	NA	0.276972057780661	p.Phe215Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F215Y	215	F	Y	missense	possibly_wt-like	1.03119027913026	0.338728565624455	3	0.195565028545495	0.647889866545541	1.41449069171498	NA	0.667210544587017	NA	NA	1.33718057301959	NA	1.08917971978417	NA	0.874212273012921	NA	0.61579635561243	NA	NA	0.879616731550554	NA	0.874212273012921	NA	p.Phe215Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.3	63.6	25.1	0.952	16.3	-154.3	-141.2	161.3	2.19298245614035	-3.5	0	1	20.09	0	0	0	0	6	24.1451419101234	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.076	-2.805	0.729	13.231	13.231	72.7	0.003346461	0	0.095647421	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.41	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
V216A	216	V	A	missense	wt-like	0.853131478105462	0.12724264267667	6	0.0519465913468549	0.751318029946007	0.954944926264918	NA	0.833559766821448	0.695558052705001	0.915344369430562	0.714248234548643	0.99365656273922	NA	0.9664218823879	0.694801756088478	NA	0.692480547478457	0.635189939174555	0.697122964698498	0.646927939083539	0.781087921199346	NA	0.779553055495014	p.Val216Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.124	-2.912	0.788	8.769	8.769	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.785	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
V216C	216	V	C	missense	wt-like	1.15517587734923	0.153352272822196	5	0.0685812213069047	1.02075915357192	1.28959260112653	NA	1.02855435446743	1.25896220879397	1.18083756785553	0.971279000111818	1.33624625551738	NA	NA	0.813555416047629	NA	0.782369770710343	0.911512894818043	0.813555416047629	0.74293865288365	0.949941024639543	NA	NA	p.Val216Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.124	-5.355	3.231	1.437	NA	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216D	216	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.124	-3.277	1.153	20.377	20.377	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216E	216	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.124	-2.77	0.646	15.185	15.185	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V216F	216	V	F	missense	wt-like	0.972755139750504	0.148884585201625	4	0.0744422926008123	0.82685092732632	1.11865935217469	NA	0.911422532177835	0.882928319652685	0.901289407405671	1.19538029976583	NA	NA	NA	0.727730059939562	NA	0.72837397191175	0.727086147967373	0.690959139440883	0.826648965523345	NA	NA	NA	p.Val216Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.124	-3.163	1.039	14.06	14.06	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V216G	216	V	G	missense	low	0.513163933085225	0.102707250311788	5	0.045932078695849	0.423138713106302	0.603189153064149	0.643923240792689	0.514354091564064	0.463633043475809	0.570051495228162	NA	NA	NA	0.373857794365403	0.54533210327554	0.613476273091466	0.54533210327554	0.52144174732108	0.545694242549393	NA	NA	NA	0.481938893658108	p.Val216Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.124	-3.184	1.06	18.598	18.598	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V216H	216	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.124	-3.853	1.729	10.191	10.191	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216I	216	V	I	missense	possibly_wt-like	1.04426822710455	0.420309455592306	5	0.187968102858065	0.675857515260424	1.41267893894868	0.377996339224136	1.44939611624709	NA	1.25333725461736	0.906709320456768	1.23390210497741	NA	NA	0.845350265414019	0.486954497592064	0.976370740309514	NA	0.845350265414019	0.718819435015149	0.899498387858832	NA	NA	p.Val216Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.124	-2.673	0.549	24.188	24.188	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.235	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V216K	216	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.124	-2.777	0.653	9.763	9.763	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V216L	216	V	L	missense	possibly_wt-like	0.734788519210942	0.141306416049731	8	0.0499593625069663	0.636869968006708	0.832707070415177	0.869056174779268	0.508081737507416	0.801252195664802	0.858959783871168	0.740853395959973	0.527905917587525	0.820812650912738	0.751386297404648	0.671973634279921	0.720589236704245	0.542440653616378	0.687027891843555	0.672395417801133	0.656865973280621	0.551532147861872	0.729671542850001	0.671551850758709	p.Val216Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.124	-2.448	0.324	15.002	15.002	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.235	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	D	0.428571428571429
V216M	216	V	M	missense	low	-0.0550059012532938	0.204454355818812	2	0.144571061442609	-0.338359974887535	0.228348172380947	NA	NA	NA	NA	-0.199576962695903	NA	0.0895651601893152	NA	0.320703067930106	NA	NA	NA	NA	0.305579660079909	NA	0.335826475780303	NA	p.Val216Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.124	-3.438	1.314	7.395	7.395	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V216N	216	V	N	missense	wt-like	1.18189700793191	0.100669579254254	4	0.0503347896271272	1.08324263309334	1.28055138277048	NA	1.23636353125603	1.11622404987965	1.29487983436976	NA	NA	NA	1.08012061622219	0.852537720549756	NA	0.87816630387309	0.841506613309381	0.863568827790132	NA	NA	NA	0.83665802364274	p.Val216Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.124	-3.497	1.373	9.981	9.981	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V216P	216	V	P	missense	low	0.472423781203425	0.316045356543025	8	0.111738907387046	0.253419547052957	0.691428015353892	0.581425709056834	0.491330110408235	0.843183919773978	0.974343389833963	0.0387528290136965	0.296871391761046	0.244375244384099	0.309107655395547	0.492068348809198	0.583741415004864	0.534718435446152	0.707593409182843	0.722997076026087	0.394604852732366	0.43766153963871	0.419206164280077	0.449418262172244	p.Val216Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.124	-3.555	1.431	17.064	17.064	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216Q	216	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.124	-2.775	0.651	6.636	6.636	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216R	216	V	R	missense	wt-like	0.969198807490649	0.187896003776476	7	0.0710180140479155	0.830006057703175	1.10839155727812	NA	1.12663300810572	0.977436179311795	1.08455352093924	0.998631562697365	0.840914801519287	0.613770210356517	1.14245236950462	0.771329898878884	NA	0.827582379417106	0.773437760447174	0.771329898878884	0.75315586969171	0.705805678474058	0.618159852318976	0.867964025616097	p.Val216Arg	0	0	NA	NA	NA	NA	NA	NA	NA	3.2225	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.124	-2.949	0.825	11.44	11.44	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V216S	216	V	S	missense	wt-like	1.05810020834179	0.117332309090306	5	0.052472603816588	0.95525579468624	1.16094462199734	1.08395023597456	0.87881532603248	1.07064245306588	1.20656419849339	NA	NA	NA	1.05052882814264	0.821795605577646	0.82283078506334	0.71334259864364	0.819151006914916	0.824837869563913	NA	NA	NA	0.821795605577646	p.Val216Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.124	-2.821	0.697	15.989	15.989	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V216T	216	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.124	-2.386	0.262	12.265	12.265	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.635	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V216V	216	V	V	synonymous	possibly_wt-like	0.743051715970001	0.319016898801782	6	0.130238103564911	0.487789723567979	0.998313708372024	NA	1.02075221577279	1.08305923241543	NA	0.551467782093999	0.811984834592164	0.219715904648978	0.771330326296644	0.686557794185666	NA	0.778773116078666	0.825240846921171	NA	0.586123282494545	0.691546887853553	0.405924806825755	0.68156870051778	p.Val216=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V216W	216	V	W	missense	possibly_wt-like	0.707352386854261	0.0463810438378587	4	0.0231905219189293	0.661899799110473	0.752804974598049	NA	0.666595832991814	0.755676447541984	0.668721405584881	NA	NA	NA	0.738415861298366	0.640094068933168	NA	0.615512983912367	0.664675153953969	0.588966083807045	NA	NA	NA	0.665037474426333	p.Val216Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.124	-5.728	3.604	0.653	NA	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V216X	216	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val216Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V216Y	216	V	Y	missense	possibly_wt-like	0.71472769893894	0.544371546973002	8	0.192464406174811	0.337504394530423	1.09195100334746	1.14018431270652	1.2144659023692	1.10987202120477	1.1624147437894	-0.219728059549433	0.592702266860228	0.0889344337391739	0.628975970391651	0.707773780011977	0.849585638332156	0.8680718654837	0.838391245204964	0.805476058160048	0.29805246313707	0.583468498829021	0.335486770681537	0.610071501863905	p.Val216Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.6	65.4	25.3	0.986	12.5	-151.5	-129.9	139.1	16.969696969697	-4.6	0	1	23.48	0	0	0	0	6	22.7655700095561	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.124	-4.514	2.39	3.261	NA	49.88	0.003172297	0	0.090669542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V217A	217	V	A	missense	low	0.14196763816659	0.117907039642278	4	0.0589535198211389	0.0264208625552894	0.25751441377789	NA	NA	NA	NA	-0.0222083973954233	0.134749818452998	0.230156111933021	0.225173019675764	0.389547891560143	NA	NA	NA	NA	0.37183352865042	0.357756243698012	0.411547833489324	0.407262254469865	p.Val217Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.921	-2.708	0.787	8.985	8.985	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V217C	217	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val217Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.921	-4.076	2.155	11.873	11.873	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217D	217	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val217Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.921	-3.599	1.678	13.683	13.683	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V217E	217	V	E	missense	low	0.287849389575756	0.253604626696305	5	0.113415436940279	0.0655592178819355	0.510139561269577	0.674842924722516	0.0582079995141689	NA	NA	0.0593183377573968	NA	0.322342844490419	0.324534841394282	0.457166536364556	0.628187132675837	0.335056431578097	NA	NA	0.402286848192399	NA	0.461198998556689	0.457166536364556	p.Val217Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.921	-3.5	1.579	10.983	10.983	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217F	217	V	F	missense	possibly_low	0.502589056476941	0.530581435685905	4	0.265290717842953	-0.0173711959280239	1.02254930888191	NA	0.41392829427252	0.0955754288124297	0.226888953103881	1.27396354971893	NA	NA	NA	0.447118640831223	NA	0.499037500846017	0.340926983928358	0.395199780816429	0.85600278199819	NA	NA	NA	p.Val217Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.921	-3.495	1.574	19.225	19.225	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V217G	217	V	G	missense	low	0.211952151553466	0.132863331269099	8	0.0469742812557073	0.119884252092624	0.304020051014307	0.137371533409809	0.160088401616936	0.28549375910261	0.398274237383507	-0.00580099757250866	0.233466847749744	0.130801040180983	0.355922390556644	0.394216376909959	0.37247086513046	0.382021582345237	0.434072896661688	0.470361061377383	0.377962313137173	0.406411171474681	0.358035848293745	0.472930871944265	p.Val217Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.921	-3.437	1.516	17.586	17.586	49.88	0.003200569	0	0.091477588	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Nov 10, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V217H	217	V	H	missense	low	0.27301958575043	0.181194853100048	3	0.104612897213087	0.0679820748943885	0.478057096606472	NA	0.192174657662346	0.146320393532418	0.480563706056527	NA	NA	NA	NA	0.396812806384633	NA	0.396812806384633	0.365814976826368	0.506449234689005	NA	NA	NA	NA	p.Val217His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.921	-5.12	3.199	1.2	NA	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217I	217	V	I	missense	wt-like	1.07449779961095	0.269972797495293	7	0.102040126132135	0.874502827414038	1.27449277180786	1.07735299992673	1.18912513878148	1.20639991483786	1.4035370491335	0.537438840611162	1.12168077753158	NA	0.985949876454308	0.844187560327085	0.81969197506241	0.856390199943636	0.885733588321304	0.911220616787982	0.58088294216923	0.844187560327085	NA	0.789360952571303	p.Val217Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.921	-2.038	0.117	19.741	19.741	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1	Neutral	TOLERATED	effect	DAMAGING	null	N	D	T	T	D	D	0.357142857142857
V217K	217	V	K	missense	low	0.250458978312517	0.113405319655226	6	0.046297527878754	0.159717491096921	0.341200465528114	0.249198717100339	0.213469861357149	0.307480763831652	0.437648055123918	0.106049088168011	NA	NA	0.188907384294035	0.422709082242235	0.425675613300612	0.40662953689905	0.444856477270413	0.487628509830626	0.419742551183857	NA	NA	0.389047909564768	p.Val217Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.921	-2.909	0.988	8.25	8.25	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217L	217	V	L	missense	low	0.469741254734583	0.260432576420136	6	0.10632115410462	0.261355621894794	0.678126887574371	NA	0.432122884358844	0.51693440948008	0.85469440482935	0.49462561488729	0.0378619732789103	NA	0.482208241573021	0.541970614381586	NA	0.507424900668885	0.547583533523682	0.670524829248514	0.564890582838908	0.310002870820353	NA	0.536357695239491	p.Val217Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.921	-2.396	0.475	19.102	19.102	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.865	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
V217M	217	V	M	missense	low	0.303624235008955	0.222264721653199	6	0.0907391926453448	0.125778685437838	0.481469784580073	NA	0.345205664615757	0.639870136179487	0.440631239892109	0.0201088333438723	0.244141204953223	0.131788331069283	NA	0.439514897884601	NA	0.467357525145798	0.607877663392323	0.48893679010842	0.387640615091694	0.411672270623404	0.358567596643042	NA	p.Val217Met	0	0	NA	NA	NA	NA	NA	NA	NA	6.037	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.921	-3.473	1.552	4.783	4.783	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V217N	217	V	N	missense	low	0.18144117174395	0.171264507728759	5	0.0765918162829089	0.0313239703189407	0.33155837316896	NA	0.420111783606995	NA	NA	-0.00947878890385324	0.0453573361691088	0.252919373681727	0.198296154165775	0.393763400990147	NA	0.501887985363812	NA	NA	0.376588518952821	0.313697130490448	0.423807975867761	0.393763400990147	p.Val217Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.921	-3.673	1.752	9.195	9.195	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217P	217	V	P	missense	low	0.0934374707994273	0.173908917596428	3	0.100406360388774	-0.103355379381319	0.290230320980173	NA	NA	NA	NA	-0.0561733236060558	NA	0.0522395522410181	0.28424618376332	0.359146343898409	NA	NA	NA	NA	0.359146343898409	NA	0.315723149953815	0.436931636351652	p.Val217Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.921	-3.297	1.376	17.923	17.923	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217Q	217	V	Q	missense	low	0.230262935578385	0.168067365490162	6	0.068613214644124	0.0957835060123856	0.364742365144384	NA	0.453293941588382	0.231882594111866	0.354153656349343	-0.0274754916137026	NA	0.237715726126861	0.13200718690756	0.411699280265126	NA	0.517184401752146	0.407779168783341	0.451011912565922	0.369866069718252	NA	0.41561939174691	0.360469895986451	p.Val217Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.921	-3.21	1.289	8.387	8.387	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217R	217	V	R	missense	low	0.23238488529785	0.117809560581685	8	0.0416519695879583	0.150748525020294	0.314021245575406	0.222473208254521	0.234146520956867	0.289246844236619	0.405634540895332	0.0284816376987789	0.191945783156047	0.142725700548362	0.34442484663627	0.414560686366328	0.412960243737198	0.416161128995458	0.435913606507015	0.473588933826242	0.390768174241517	0.385946572677406	0.364458391580051	0.46715625285038	p.Val217Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.921	-3.166	1.245	13.062	13.062	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217S	217	V	S	missense	low	0.500631674751616	0.23975191639347	6	0.0978783100030693	0.308793712277954	0.692469637225279	0.763263297318009	0.135302113950318	0.292730273073439	0.556833301993219	0.683611962020896	NA	NA	0.572049100153817	0.560688737716031	0.670255469745589	0.370595520873216	0.437622062757401	0.539897383534243	0.635484132397134	NA	NA	0.581480091897819	p.Val217Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.921	-2.876	0.955	6.931	6.931	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V217T	217	V	T	missense	low	0.276234225009301	0.136786306719131	7	0.0517003643339749	0.174903372927111	0.377565077091491	0.360465993316191	0.355214797111244	0.299899287529796	0.425619557461077	0.0130305154636137	NA	0.194377983823062	0.285031440360125	0.441138123550035	0.478613970641578	0.471971566776932	0.441138123550035	0.482353393642188	0.384996595607494	NA	0.392277970079393	0.437326029951617	p.Val217Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.921	-2.849	0.928	15.56	15.56	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.415	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V217V	217	V	V	synonymous	wt-like	1.09059191538401	0.0993910102970089	4	0.0496955051485044	0.993190515099419	1.18799331566861	NA	1.09144534176121	1.00584263123413	1.22983653436661	NA	NA	NA	1.03524315417409	0.812739931476364	NA	0.811361457425196	0.787369774738678	0.83504398832859	NA	NA	NA	0.814118405527532	p.Val217=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V217W	217	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val217Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.921	-4.174	2.253	15.155	15.155	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V217X	217	V	X	nonsense	low	0.012127989548104	0.139461139104954	8	0.0493069585865566	-0.0845118734687548	0.108767852564963	0.237743870403977	0.00406347349394028	-0.0259383695367189	-0.0171849285708951	-0.250115425738496	0.018377061445026	0	0.130078234887999	0.294280046875191	0.420225666215347	0.310096716311266	0.281330242320365	0.288160803839688	0.286701632383698	0.300399289910695	0.287587272269366	0.359501083582647	p.Val217Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V217Y	217	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val217Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.5	66.5	28.4	0.95	15.7	-173.5	-114.6	128	0	-7	0	1	23.08	0	0	0	0	8	22.4204874581263	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.921	-3.535	1.614	7.876	7.876	49.88	0.003200569	0	0.091477588	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.76	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C218A	218	C	A	missense	possibly_wt-like	0.866228803493411	0.445355532152636	7	0.168328569011815	0.536310870661089	1.19614673632573	0.147068815015808	0.884199538926117	0.596458696709719	0.732949864792004	1.57237840434015	1.11061360530812	1.01993269936196	NA	0.715824630173678	0.377084604015364	0.715824630173678	0.586586416010878	0.617133573581652	0.967472018523095	0.838732853382796	0.836916285336329	NA	p.Cys218Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.843	-2.776	-0.067	10.494	10.494	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.155	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218C	218	C	C	synonymous	wt-like	1.11630711893276	0.065661314125125	7	0.0248176439903962	1.06766543053045	1.16494880733507	1.00559594720056	1.1113110391066	1.08168022928654	1.09343762430716	1.14681092016692	NA	1.16826133930746	1.20705273315409	0.820519209570495	0.785551654312726	0.820519209570495	0.82456451144104	0.775226036103123	0.808506464979092	NA	0.916805110787063	0.900409432738316	p.Cys218=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	0	2.5	2.5	0	148	148	0	5.5	5.5	0	121	121	0	5.07	5.07	0	NA	NA	NA	NA	NA	NA	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
C218D	218	C	D	missense	possibly_wt-like	0.713092874034079	0.145474681792149	3	0.0839898466929723	0.548475799448813	0.877709948619345	NA	0.648414733966657	0.611173101935917	0.879690786199663	NA	NA	NA	NA	0.607131803241648	NA	0.607131803241648	0.593803132285858	0.681487030823051	NA	NA	NA	NA	p.Cys218Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.843	-3.539	0.696	10.533	10.533	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218E	218	C	E	missense	wt-like	0.981399244496132	0.253024667898202	8	0.0894577292391465	0.806065317048669	1.15673317194359	0.981494288464355	1.08859557733633	1.10202877971303	1.21982821377363	0.444637122339447	1.19388758693942	0.805714702570609	1.01500768483223	0.807001472177197	0.774084651020474	0.810047763985603	0.834544508102655	0.830654823907649	0.546217989926561	0.879776324715055	0.721539887626763	0.803955180368792	p.Cys218Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.843	-3.088	0.245	9.361	9.361	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218F	218	C	F	missense	possibly_wt-like	0.852505480246664	0.310985599806387	8	0.109950013237231	0.637007414201989	1.06800354629134	0.575776016459521	0.924933076341517	1.10210554813414	1.28652441542948	0.666768263944535	0.321715977046503	0.963471012182057	0.978749532435565	0.760173349586556	0.581053423928288	0.734602105394707	0.834582159363816	0.859904545936443	0.629192374008594	0.449906757219878	0.806506393669912	0.785744593778405	p.Cys218Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.843	-3.045	0.202	19.703	19.703	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
C218G	218	C	G	missense	possibly_low	0.671568668292559	0.116120930192366	8	0.0410549485883558	0.591102447672238	0.75203488891288	0.727786740186188	0.680022656332108	0.742864685475668	0.864649794898674	0.617047885217154	0.483033380422048	0.571223919891359	0.685920283917273	0.630187098096059	0.653376556892287	0.621702523504727	0.658391593701696	0.674890780906728	0.610619931750298	0.529415699762739	0.595244701382541	0.63867167268739	p.Cys218Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.843	-2.875	0.032	17.839	17.839	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.5	Neutral	TOLERATED	effect	DAMAGING	pathogenic	N	D	T	T	D	D	0.428571428571429
C218H	218	C	H	missense	possibly_wt-like	0.859824983051651	0.243660803181897	8	0.0861471031196402	0.690979763564698	1.0286702025386	0.399249535106076	0.970696477073261	0.931909653279906	0.755240902684061	0.947258952412679	0.692946174522324	1.21907237024634	0.962225799088554	0.742537710050029	0.497066269143415	0.755698262954189	0.751109163653286	0.626909342604307	0.733966256446772	0.632875983252897	0.944171596336583	0.777445580811051	p.Cys218His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.843	-3.534	0.691	17.043	17.043	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.155	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218I	218	C	I	missense	wt-like	0.967392009174097	0.130551036587905	4	0.0652755182939525	0.839454344245765	1.09532967410243	0.880597436722013	NA	NA	NA	0.834271523363656	NA	1.04823732877331	1.10646174783742	0.787984051974685	0.726080298134611	NA	NA	NA	0.691761177651371	NA	0.852160971725426	0.84988780581476	p.Cys218Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.843	-2.773	-0.07	9.096	9.096	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C218K	218	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys218Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.843	-2.957	0.114	10.863	10.863	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.95	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218L	218	C	L	missense	wt-like	0.970499123181663	0.166164141949737	8	0.0587478957813517	0.855355363282701	1.08564288308063	0.604959463158768	1.04110240584128	1.0648631343256	1.14790569518704	0.967754165736487	0.898022555968733	0.973913367573136	1.06547219766227	0.793633651874778	0.59493822260718	0.788154211215516	0.816316525808125	0.799113092534041	0.741621993908366	0.733952531028474	0.812130577289737	0.829300883883399	p.Cys218Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.843	-2.629	-0.214	15.095	15.095	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C218M	218	C	M	missense	wt-like	1.19941599177333	0.157756229652817	5	0.0705507306755532	1.06113910056626	1.3376928829804	NA	0.967266413586508	NA	NA	1.34583543810379	1.34756900881903	1.18082212231347	1.15558697604384	0.882849651052456	NA	0.754117061413252	NA	NA	0.882849651052456	0.955521700517349	0.923570265523604	0.874560856229429	p.Cys218Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.843	-3.117	0.274	5.587	5.587	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C218N	218	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys218Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.843	-3.597	0.754	15.797	15.797	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.155	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218P	218	C	P	missense	low	0.338762321392956	0.221810745244607	7	0.0838365814341618	0.174445641195039	0.503079001590872	0.273708029732164	0.274501259947307	0.209719005651152	0.341958809323584	0.823826396536117	0.158767147008535	NA	0.288855601551831	0.437336568744223	0.437336568744223	0.434763984517591	0.396908982248609	0.445663843607997	0.687859527666991	0.369593729029397	NA	0.439246707479674	p.Cys218Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.843	-3.866	1.023	13.013	13.013	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218Q	218	C	Q	missense	possibly_wt-like	0.892298851011563	0.244467598093046	6	0.0998034789952928	0.696687626648989	1.08791007537414	NA	1.0790220679145	0.750056178661871	0.806019446360978	0.509916803677181	1.1114109894918	NA	1.09736761996305	0.733776608251408	NA	0.805634537260082	0.661918679242734	0.649178351194043	0.570602420281219	0.839125862270355	NA	0.845320297760064	p.Cys218Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.843	-3.521	0.678	6.742	6.742	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C218R	218	C	R	missense	wt-like	1.01990238001752	0.329589340979741	8	0.11652742900679	0.791512815953167	1.24829194408188	1.16176964885101	1.09683998842118	1.24125117603869	1.28875816562656	1.10705137944946	0.268382193550099	1.13848333082533	0.856683157377858	0.836851866583656	0.859855434421394	0.813848298745919	0.902826475192724	0.860884160528044	0.793654772512302	0.423619991881006	0.900766872165221	0.724436994084835	p.Cys218Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.843	-3.339	0.496	15.11	15.11	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.95	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
C218S	218	C	S	missense	wt-like	1.1089113444786	0.202362242870155	7	0.0764857384833834	0.959002051720216	1.25882063723698	0.725564179542711	1.4008616256477	1.08889174840822	1.14013494332326	1.0878703687595	NA	1.21684442070889	1.1022121249599	0.828101418751441	0.65231911472638	0.953997156957268	0.828101418751441	0.795705217327847	0.786489939447609	NA	0.94297163743602	0.847753440981692	p.Cys218Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.843	-2.73	-0.113	18.827	18.827	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	neutral	0.46	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
C218T	218	C	T	missense	wt-like	1.0501943466757	0.179214886995706	7	0.0677368603187402	0.917432540025148	1.18295615332625	NA	1.26893190494952	1.04882531305906	0.89852753241507	1.25454142212901	0.845401743724915	1.1517864399074	0.883346070544909	0.808450736877468	NA	0.893179776034424	0.808450736877468	0.689747914907134	0.848747882650482	0.708017169748746	0.907931838821696	0.73782839041603	p.Cys218Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.843	-2.919	0.076	13.486	13.486	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.605	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C218V	218	C	V	missense	possibly_wt-like	0.760863042194375	0.235809253689792	8	0.0833711611752953	0.597458568941512	0.924267515447237	0.971479869990322	0.679341707280929	0.747942864878514	0.259995889012324	0.700540603980905	0.876504226788404	0.836255075596421	1.01484410002718	0.692114466767707	0.769320025860495	0.621388617452206	0.660882199294	0.409718878583703	0.641807620539442	0.723346734241415	0.737988730754806	0.803873020218307	p.Cys218Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.843	-2.584	-0.259	9.82	9.82	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C218W	218	C	W	missense	possibly_low	0.41762365331075	0.653052878406916	2	0.461778118794924	-0.48744482837596	1.32269213499746	NA	-0.0441544654841741	0.879401772105674	NA	NA	NA	NA	NA	0.506612800984202	NA	0.287869057929003	0.725356544039401	NA	NA	NA	NA	NA	p.Cys218Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.843	-3.601	0.758	36.101	36.101	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.455	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
C218X	218	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys218Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C218Y	218	C	Y	missense	wt-like	1.20544261261559	0.104051940591531	4	0.0520259702957654	1.10347358457514	1.30741164065604	NA	1.34916036885844	1.11181254612353	1.15036006038188	1.21043747509851	NA	NA	NA	0.835808185258405	NA	0.930163747686771	0.839342980429591	0.800189458172924	0.832273390087218	NA	NA	NA	p.Cys218Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.8	69.5	28.3	0.918	20.8	-157.4	-122.2	148.2	17.5675675675676	-6.5	0	1	28.03	0	0	0	0	8	20.4551723986868	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.843	-2.644	-0.199	28.826	28.826	86.35	0.003078421	0	0.087986408	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.8	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	T	B	0.214285714285714
Q219A	219	Q	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.22	-3.2	0.98	9.056	9.056	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q219C	219	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.22	-4.293	2.073	17.509	17.509	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219D	219	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.22	-2.507	0.287	16.144	16.144	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219E	219	Q	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.22	-2.478	0.258	13.416	13.416	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Q219F	219	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.22	-3.713	1.493	14.156	14.156	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219G	219	Q	G	missense	possibly_wt-like	0.785293104949343	0.194920133064676	7	0.0736728853726786	0.640896902981745	0.929689306916941	0.891789322260951	0.763378234623706	0.713721903769947	0.788533037217401	1.04377196508884	NA	0.878644038358153	0.417213233326402	0.660128042259533	0.731405134475801	0.660128042259533	0.644098444654841	0.641509659513959	0.770017517538938	NA	0.760819146029658	0.503714078635161	p.Gln219Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.22	-3.331	1.111	16.447	16.447	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219H	219	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.22	-3.152	0.932	16.779	16.779	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.015	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Q219I	219	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.22	-3.005	0.785	9.433	9.433	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219K	219	Q	K	missense	possibly_wt-like	0.749769265822779	0.21052959770597	7	0.0795727084497816	0.593809623108901	0.905728908536657	0.927982097897565	1.09045344840184	0.480671296000892	0.600940226353051	0.781605661959514	0.600557198774217	0.766174931372375	NA	0.672088486192704	0.748624807276056	0.810904211279652	0.529798200225889	0.559240543190128	0.672088486192704	0.587339980251106	0.700244028103084	NA	p.Gln219Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.22	-2.58	0.36	11.069	11.069	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.91	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
Q219L	219	Q	L	missense	possibly_wt-like	0.823689188431103	0.124712203017756	2	0.088184844450569	0.650850069325721	0.996528307536485	0.911874032881672	NA	NA	NA	NA	NA	NA	0.735504343980534	0.70226806934393	0.74096096817723	NA	NA	NA	NA	NA	NA	0.66357517051063	p.Gln219Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.22	-2.953	0.733	18.729	18.729	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q219M	219	Q	M	missense	wt-like	0.926370481116878	0.159551744583647	8	0.0564100602726204	0.815808794616808	1.03693216761695	0.730163360998508	0.994380978782438	0.869218880152954	1.10675158001398	1.08386451038659	0.921200203627868	1.03099376235312	0.674390572619571	0.755996290110062	0.654507297269023	0.766616419642402	0.7203623196075	0.781064891897904	0.784993599813236	0.745376160577722	0.842873700781685	0.632880897590744	p.Gln219Met	0	0	NA	NA	NA	NA	NA	NA	NA	-0.316	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.22	-3.187	0.967	10.249	10.249	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.105	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219N	219	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.22	-2.868	0.648	11.16	11.16	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219P	219	Q	P	missense	low	0.382283192557401	0.233415492451314	5	0.104386581624545	0.177689252104042	0.58687713301076	0.732502898168604	0.24575407421489	0.37117050788882	0.448318374364173	NA	NA	NA	0.113670108150518	0.476093269068723	0.655620394119553	0.421512015697405	0.476093269068723	0.492307994778606	NA	NA	NA	0.351260133810301	p.Gln219Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.22	-3.421	1.201	13.872	13.872	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q219R	219	Q	R	missense	possibly_low	0.67766626215282	0.109687212627533	8	0.0387802859291895	0.601658298421443	0.753674225884197	0.871403207486248	0.618718202711741	0.588419851682214	0.59072607889099	0.759534102014665	0.69550683714654	0.55113047232591	0.745891344964251	0.613790133020645	0.721705899755221	0.593442202112656	0.58264374467281	0.55476111307853	0.663843923638709	0.634138063928635	0.584422503283444	0.668792021572401	p.Gln219Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.22	-3.243	1.023	10.5	10.5	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Q219S	219	Q	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.22	-2.674	0.454	14.134	14.134	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q219T	219	Q	T	missense	wt-like	0.90300904282017	0.159049844643274	4	0.0795249223216371	0.747143059196416	1.05887502644392	0.721407141443808	0.890158327196915	NA	NA	NA	0.891056008863155	NA	1.1094146937768	0.724545220749695	0.650341293610917	0.718571531282737	NA	NA	NA	0.730518910216651	NA	0.851370917175142	p.Gln219Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.22	-2.89	0.67	7.506	7.506	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219V	219	Q	V	missense	wt-like	0.916542402184651	0.13486316130824	6	0.0550576550506411	0.808631381212165	1.02445342315714	NA	NA	1.10171810238827	0.87026105801771	0.878346230560862	0.715103869573199	1.02773041824462	0.906094734323248	0.728739305314046	NA	NA	0.834392135643732	0.677351608995697	0.708224748030826	0.643796906016456	0.841116085206128	0.749253862597265	p.Gln219Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.22	-3.244	1.024	11.157	11.157	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219W	219	Q	W	missense	possibly_low	0.685739524557084	0.204150577990723	7	0.0771616656247926	0.534505438945368	0.836973610168799	NA	0.637112166031447	1.00543957721715	0.918899227596609	0.548265827632798	0.51353030426813	0.69720478917281	0.47972477998064	0.60192150964075	NA	0.60192150964075	0.787172095903597	0.698681953225989	0.584927231380968	0.544446800654979	0.66309716520784	0.535110381480168	p.Gln219Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.22	-5.745	3.525	0.907	NA	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q219X	219	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	1	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q219Y	219	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln219Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.2	71	30.9	0.982	79.6	-44.5	-117.6	109.7	26.6355140186916	-5.7	0	1	30.94	1	31	0	0	5	20.917485935456	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.22	-3.519	1.299	10.475	10.475	49.88	0.003204481	0	0.091589394	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L220A	220	L	A	missense	wt-like	1.17211967000673	0.109207935532483	4	0.0546039677662414	1.06509785977191	1.27914148024155	NA	1.25281845057823	1.27951466476868	1.08273686341547	NA	1.07340870126453	NA	NA	0.853073658498923	NA	0.885751744751591	0.921592897457867	0.77053320092199	NA	0.820395572246255	NA	NA	p.Leu220Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.369	-2.647	0.278	13.225	13.225	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.86	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
L220C	220	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.369	-3.809	1.44	18.348	18.348	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220D	220	L	D	missense	wt-like	1.34053196322723	0.342014519627311	3	0.197462174973589	0.953513211970051	1.72755071448441	NA	0.979355709427183	NA	NA	1.65945922740996	1.38278095284455	NA	NA	0.972876706088755	NA	0.759690023338286	NA	NA	1	0.972876706088755	NA	NA	p.Leu220Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.369	-3.243	0.874	15.948	15.948	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220E	220	L	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.369	-2.764	0.395	10.836	10.836	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220F	220	L	F	missense	wt-like	1.12733839778374	0.252670597429428	7	0.0955005092023403	0.940160839241919	1.31451595632557	NA	1.05148456364296	0.930374129057452	0.964347402148659	1.65945922740996	0.971065177457701	1.12148475904704	1.19315352572242	0.792940211234953	NA	0.792940211234953	0.750356062017408	0.718613320220815	1	0.76995324436519	0.8916115537169	0.893428582812399	p.Leu220Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.369	-3.561	1.192	12.721	12.721	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220G	220	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.369	-2.703	0.334	23.026	23.026	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220H	220	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.369	-3.226	0.857	17.043	17.043	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220I	220	L	I	missense	possibly_wt-like	0.71539082997144	0.231847320492832	5	0.10368527380463	0.51217142758719	0.91861023235569	1.00486192208872	0.603440183886266	0.427713494274487	0.892659168216433	NA	NA	NA	0.648279381391291	0.619766602531283	0.785202422400261	0.586399292556431	0.503824915969336	0.687174334743461	NA	NA	NA	0.619766602531283	p.Leu220Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.369	-2.704	0.335	12.869	12.869	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
L220K	220	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.369	-2.889	0.52	9.763	9.763	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.86	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L220L	220	L	L	synonymous	wt-like	1.04637571885815	0.21143947588647	7	0.0799166100767768	0.889742041341139	1.20300939637516	NA	1.02137281586458	1.10352286954603	0.917617164373219	0.653047819025141	1.30170867149021	1.17686556333177	1.15049512837611	0.835277288140198	NA	0.779059202276555	0.835277288140198	0.698119702423447	0.624067268819417	0.932918392694543	0.921439288997488	0.872003485631946	p.Leu220=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L220M	220	L	M	missense	wt-like	0.919212567381356	0.164901598232571	4	0.0824507991162853	0.757611970616889	1.08081316414582	0.833412784964535	NA	NA	NA	0.752643238911107	0.959882260420159	NA	1.13091198522962	0.734036219370435	0.703630948777836	NA	NA	NA	0.661269925604575	0.764441489963034	NA	0.862167890037344	p.Leu220Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.369	-3.396	1.027	11.776	11.776	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
L220N	220	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.369	-2.831	0.462	11.474	11.474	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220P	220	L	P	missense	wt-like	1.1418526131164	0.127186314493267	8	0.044967152726157	1.05371861328582	1.22998661294697	1.23098635331314	0.974106348227326	1.05481424149015	1.16633707401465	1.38309609747753	1.06127661667011	1.1773494884516	1.08685468528666	0.827228097911468	0.892787117117319	0.757270156169586	0.811388021573241	0.807196202125452	0.89676791681063	0.814415999077097	0.921699927869678	0.84004019674584	p.Leu220Pro	1	0	NA	NA	NA	NA	NA	NA	NA	21.236	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.369	-3.358	0.989	20.992	20.992	72.7	0.002972728	0	0.084965526	4.061e-06	1	246222	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
L220Q	220	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.369	-3.022	0.653	11.679	11.679	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
L220R	220	L	R	missense	possibly_low	0.705498330840229	0.569048245860708	6	0.232312973564094	0.250173269513199	1.16082339216726	NA	1.13680768396913	1.21937168346481	0.879971743487295	-0.244624816931115	NA	0.287985494505195	0.953478196546062	0.727331179752766	NA	0.83227273375483	0.892095624185229	0.681610245074555	0.288752582469921	NA	0.4426943568575	0.773052114430977	p.Leu220Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.369	-2.987	0.618	11.952	11.952	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.77	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
L220S	220	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.369	-3.046	0.677	11.296	11.296	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
L220T	220	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.369	-3.309	0.94	7.261	7.261	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220V	220	L	V	missense	possibly_wt-like	0.891234368830458	0.365074479427821	6	0.149041032118393	0.599119313659731	1.18334942400118	NA	1.03405429872175	1.15208631451333	1.19256295270976	0.297001347615725	NA	0.582958285200912	1.08874301422126	0.80180137704832	NA	0.784905152449948	0.859095349303869	0.818697601646691	0.491070443357188	NA	0.601564753008002	0.840988606284156	p.Leu220Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.369	-2.621	0.252	10.355	10.355	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
L220W	220	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.369	-4.089	1.72	20.7	20.7	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L220X	220	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu220Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L220Y	220	L	Y	missense	possibly_low	0.57766287328066	0.686514265345555	4	0.343257132672778	-0.0951087441944715	1.25043449075579	0.479264314907284	NA	NA	1.19465852545557	-0.348369550675429	NA	NA	0.985098203435211	0.662034311993421	0.53513542253455	NA	NA	0.819616618304076	0.25	NA	NA	0.788933201452292	p.Leu220Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	74.6	29.8	0.43	125.5	-24.5	61.4	-135.4	41.3612565445026	-1.9	0	0	37.36	0	0	0	0	4	18.1570217232893	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.369	-3.731	1.362	17.406	17.406	72.7	0.002972728	0	0.084965526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K221A	221	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.01	-3.052	1.042	14.878	14.878	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K221C	221	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.01	-5.486	3.476	1.329	NA	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.955	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K221D	221	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.01	-2.779	0.769	16.144	16.144	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.045	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K221E	221	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.01	-2.798	0.788	11.573	11.573	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.85	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K221F	221	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.01	-3.361	1.351	10.999	10.999	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K221G	221	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.01	-2.899	0.889	23.279	23.279	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K221H	221	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.01	-3.445	1.435	15.022	15.022	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K221I	221	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.01	-3.402	1.392	8.085	8.085	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K221L	221	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.01	-3.059	1.049	13.138	13.138	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K221M	221	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.01	-3.489	1.479	4.783	4.783	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K221N	221	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.01	-2.582	0.572	17.369	17.369	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
K221P	221	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.01	-3.09	1.08	18.292	18.292	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K221Q	221	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.01	-2.963	0.953	10.67	10.67	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K221R	221	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.01	-2.527	0.517	14.257	14.257	49.88	0.002813179	0	0.080405346	4.061e-06	1	246222	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K221S	221	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.01	-2.628	0.618	8.622	8.622	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K221T	221	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.01	-2.975	0.965	17.879	17.879	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.81	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
K221V	221	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.01	-3.382	1.372	7.883	7.883	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K221W	221	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.01	-5.763	3.753	0.853	NA	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K221X	221	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	3	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K221Y	221	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys221Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.2	74.4	26	0.301	119.7	96.8	-91.8	12.8	77.8260869565217	-1.1	0	0	47.16	0	0	0	0	3	18.0167504800394	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.01	-3.89	1.88	9.845	9.845	49.88	0.002813179	0	0.080405346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V222A	222	V	A	missense	wt-like	1.12527159885526	0.132150521448777	7	0.0499482021972817	1.02737492145607	1.22316827625446	1.26634180747834	1.08367154356092	1.05138481454482	1.06064508901186	1.33124562810513	1.13442658814115	0.949185721144631	NA	0.809706050683507	0.909608412022739	0.807777867284458	0.809706050683507	0.760844819209296	0.877399805120158	0.850469622288245	0.798812430301669	NA	p.Val222Ala	1	0	NA	NA	NA	NA	NA	NA	NA	1.5565	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.133	-3.052	0.919	13.225	13.225	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.93	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V222C	222	V	C	missense	possibly_wt-like	0.810498095987366	0.286652567239058	5	0.128194925254273	0.559240659488187	1.06175553248654	NA	0.693779675459556	0.931206370571187	1.07522801415465	0.364450856578592	NA	NA	0.98782556317284	0.750764236917077	NA	0.628044277797916	0.750764236917077	0.76724018350597	0.516265386409249	NA	NA	0.790303012581162	p.Val222Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.133	-3.977	1.844	14.751	14.751	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V222D	222	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.133	-3.201	1.068	15.554	15.554	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V222E	222	V	E	missense	wt-like	0.925460938878303	0.0804054091217988	8	0.0284276050170513	0.869743856878152	0.981178020878454	1.01373876743703	0.888162341829382	0.930510351422854	0.983257930589262	0.790718925776071	1.02992136419744	0.892287316140897	0.875090513633491	0.742052462805023	0.789425816978535	0.717651415619858	0.750422872611945	0.726906561613472	0.675492634961273	0.798961851445775	0.768167325300782	0.733682052998101	p.Val222Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.133	-2.894	0.761	11.72	11.72	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V222F	222	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.133	-3.377	1.244	24.39	24.39	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V222G	222	V	G	missense	wt-like	0.974502917005809	0.145493748151137	8	0.0514398079689583	0.873682746014994	1.07532308799662	1.00375171847253	0.872190152309851	0.805434901172062	0.951527153175069	1.23890638322665	0.818569903034003	1.02780333754353	1.07783978711278	0.748832596931659	0.784674213588523	0.71028850505626	0.689079310058812	0.712990980274795	0.842907604184131	0.694792488250207	0.841155359058734	0.835512481654263	p.Val222Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.133	-2.782	0.649	20.749	20.749	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
V222H	222	V	H	missense	wt-like	1.24456505918514	0.170752982709266	5	0.0763630553397531	1.09489622096979	1.3942338974005	NA	1.34363811162843	1.26952959975743	1.4599437708154	1.10800749552063	NA	1.04170631820382	NA	0.916695697736525	NA	0.92761808004089	0.916695697736525	0.93595787151599	0.79401191803248	NA	0.848643412583817	NA	p.Val222His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.133	-5.119	2.986	1.848	NA	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V222I	222	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.133	-2.559	0.426	11.319	11.319	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V222K	222	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.133	-2.533	0.4	12.513	12.513	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V222L	222	V	L	missense	wt-like	0.976710363874907	0.225177600133126	4	0.112588800066563	0.756040370681863	1.19738035706795	NA	1.05683213494552	1.06355367668994	1.14244151136997	NA	0.644014132494194	NA	NA	0.7960610589539	NA	0.795405351608168	0.815674299086394	0.796716766299632	NA	0.608758716072106	NA	NA	p.Val222Leu	1	0	NA	NA	NA	NA	NA	NA	NA	0.294	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.133	-2.61	0.477	16.027	16.027	42.68	0.003012709	0	0.08610823	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Mar 18, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
V222M	222	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.133	-3.666	1.533	9.485	9.485	42.68	0.003012709	0	0.08610823	0	NA	NA	not specified	Uncertain significance(Last reviewed: Jan 12, 2017)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.135	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V222N	222	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.133	-3.26	1.127	12.417	12.417	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V222P	222	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.133	-3.611	1.478	15.959	15.959	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V222Q	222	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.133	-2.838	0.705	8.865	8.865	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V222R	222	V	R	missense	possibly_wt-like	0.877857538561092	0.133272738307252	2	0.0942380570043582	0.693154340859518	1.06256073626267	0.783619481556734	NA	NA	NA	NA	NA	NA	0.972095595565451	0.731171565567086	0.679940464219954	NA	NA	NA	NA	NA	NA	0.782402666914219	p.Val222Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.133	-2.934	0.801	13.403	13.403	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V222S	222	V	S	missense	wt-like	1.07610097596206	0.0319764054204736	8	0.0113053665553936	1.05394286468147	1.09825908724266	1.11177890146607	1.02921183981808	1.04880277648289	1.07686671866932	1.09506895910711	1.08482188695183	1.04610150072221	1.11615522447899	0.817230251767714	0.836071010655399	0.782672860391803	0.808439683758195	0.767958839896458	0.789178885247984	0.826020819777234	0.851010628848761	0.854756335623234	p.Val222Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.133	-2.697	0.564	8.131	8.131	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V222T	222	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.133	-2.697	0.564	9.275	9.275	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V222V	222	V	V	synonymous	wt-like	1.12893366426312	0.189645667169575	5	0.0848121206858941	0.9627049622663	1.29516236625993	1.25133686802191	1.08889908910568	1.05723918386592	1.37065886729674	NA	NA	NA	0.87653431302534	0.812577340532458	0.902469414162459	0.810187677803303	0.812577340532458	0.896801839471399	NA	NA	NA	0.734407198437305	p.Val222=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V222W	222	V	W	missense	wt-like	0.880844287095692	0.153196526735142	7	0.0579028444942918	0.767356797284457	0.994331776906927	0.584836917127062	0.85314716873411	0.975420537972565	0.855214179339202	0.847229868968613	NA	1.03266733374782	1.01739400378047	0.701510010112858	0.585364387705623	0.701510010112858	0.772449184189165	0.670752777160889	0.696601609918203	NA	0.8437750752774	0.805153704423848	p.Val222Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.133	-5.761	3.628	1.133	NA	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V222X	222	V	X	nonsense	low	-0.0397374968929999	0.0493078732291004	3	0.028467913881989	-0.0955335828166863	0.0160585890306864	NA	-0.0960441749941369	-0.00427424243332869	-0.0188940732515342	NA	NA	NA	NA	0.287411255805849	NA	0.263948775125836	0.291955466802557	0.287411255805849	NA	NA	NA	NA	p.Val222Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V222Y	222	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val222Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.5	70.8	26.1	0.891	69.9	-138.3	-107.5	121.9	56.3636363636364	-6	0	1	42.82	0	0	0	0	7	21.6051363767971	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.133	-3.929	1.796	12.444	12.444	42.68	0.003012709	0	0.08610823	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K223A	223	K	A	missense	possibly_wt-like	0.811523248359341	0.658029211308081	6	0.268639300591808	0.284999894367367	1.33804660235131	1.05804746739775	1.34512554178996	1.15317864252662	1.32866198430427	-0.222780387499144	NA	0.206906241636597	NA	0.835068970134351	0.810506856001039	0.92830376031256	0.859631084267663	0.87838404170918	0.29691230318555	NA	0.399025606962163	NA	p.Lys223Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.035	-3.178	1.143	8.481	8.481	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223C	223	K	C	missense	wt-like	1.03910020373378	0.406893996669785	6	0.166113778540449	0.713523180458637	1.36467722700892	NA	1.10827163645904	1.2015050552228	1.23415515139898	0.217055179975366	1.28514503838829	NA	1.18846916095819	0.860135408427165	NA	0.819118096101775	0.883332892370316	0.836937924484015	0.461207525570222	0.9247546302917	NA	0.891075869711447	p.Lys223Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.035	-5.471	3.436	1.003	NA	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223D	223	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.035	-3.012	0.977	16.44	16.44	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223E	223	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.035	-2.539	0.504	21.598	21.598	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.885	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
K223F	223	K	F	missense	possibly_wt-like	0.728709808488704	0.548573936282211	6	0.223954371680245	0.289767305815127	1.16765231116228	0.750011614286065	0.112716131060425	0.952379285888924	NA	1.65945922740996	0.287919055982323	NA	0.609773536304525	0.632188873389128	0.66395063012362	0.360183762873107	0.761148545369467	NA	1	0.433249177821815	NA	0.600427116654636	p.Lys223Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.035	-3.7	1.665	14.06	14.06	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223G	223	K	G	missense	possibly_wt-like	0.711363218962227	0.129020181921788	8	0.0456155227734091	0.621958437190378	0.800768000734075	0.927318540232407	0.790936855203892	0.637579979246874	0.818893124084709	0.711637428671604	0.534438214493407	0.592633599699142	0.677468010065777	0.640189619448213	0.748309102120064	0.672832102547568	0.60675445028559	0.654824122400782	0.645952704327891	0.554751738609646	0.606775813470864	0.634426534568535	p.Lys223Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.035	-3.502	1.467	11.133	11.133	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223H	223	K	H	missense	wt-like	0.890865750577491	0.174811828320339	7	0.0660726605668766	0.761365715503673	1.02036578565131	NA	0.871279312950862	1.0131164262389	1.11454054708557	0.56446203995935	0.974418068196858	0.826869785385853	0.871374074225047	0.732933875457056	NA	0.709868623440791	0.790937225409286	0.784480755411557	0.590977129349109	0.771605792643019	0.732933875457056	0.73181547852638	p.Lys223His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.035	-3.648	1.613	14.407	14.407	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223I	223	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.035	-2.876	0.841	10.107	10.107	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223K	223	K	K	synonymous	wt-like	1.20148925378365	0.0938143437418025	4	0.0469071718709013	1.10955288630005	1.29342562126724	1.30518884019148	1.16519210279116	1.09013250911933	1.24544356303262	NA	NA	NA	NA	0.84362297396913	0.928090918015019	0.845357473134539	0.828709952897371	0.841888474803721	NA	NA	NA	NA	p.Lys223=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K223L	223	K	L	missense	possibly_wt-like	0.708819541287552	0.559694350924696	4	0.279847175462348	0.160329156206089	1.25730992636901	1.01725577241728	0.72844893851361	1.1734525959175	NA	NA	-0.0838791416981843	NA	NA	0.717562674981138	0.791099125364848	0.644026224597428	0.869574494629486	NA	NA	0.25	NA	NA	p.Lys223Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.035	-2.517	0.482	23.761	23.761	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.69	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K223M	223	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.035	-4.095	2.06	5.104	5.104	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K223N	223	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.035	-3.074	1.039	9.745	9.745	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K223P	223	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.035	-2.962	0.927	19.274	19.274	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.69	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K223Q	223	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.035	-2.587	0.552	8.706	8.706	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.69	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K223R	223	K	R	missense	wt-like	0.977411224966575	0.195541850311252	8	0.0691344841804257	0.841910125883186	1.11291232404996	1.10811322108708	1.20530611060712	1.09338801634678	0.648731696776987	0.737655257886883	0.92205369861187	0.999696043613187	1.10434575480269	0.828161790344556	0.834326966005432	0.863849355636633	0.830306624433226	0.580199566201073	0.655671347732368	0.745796824946375	0.826016956255885	0.848825052424516	p.Lys223Arg	1	0	NA	NA	NA	NA	NA	NA	NA	0.65	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.035	-2.741	0.706	13.915	13.915	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K223S	223	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys223Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.035	-3.087	1.052	7.967	7.967	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223T	223	K	T	missense	wt-like	1.19738052099852	0.0800182695204269	2	0.0565814609967067	1.08648289525232	1.30827814674472	NA	NA	NA	NA	1.25396198199523	NA	1.14079906000182	NA	0.875272774220533	NA	NA	NA	NA	0.848531439841673	NA	0.902014108599394	NA	p.Lys223Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.035	-2.995	0.96	10.496	10.496	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.69	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K223V	223	K	V	missense	wt-like	0.958116607162615	0.208116865778588	8	0.0735804235356651	0.813901627065508	1.10233158725972	0.721140456133486	1.01304378366633	1.13532888186044	1.15822104261276	0.820214685113257	1.08949476921225	1.10713570048347	0.620353538218933	0.789428281326386	0.650214411002341	0.7752196586071	0.850876625196851	0.803636904045672	0.686510416828104	0.828323955826905	0.883883245580392	0.605740902058839	p.Lys223Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.035	-2.558	0.523	10.689	10.689	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223W	223	K	W	missense	possibly_wt-like	0.788215975105037	0.262273958639349	5	0.11729248004911	0.558326938551398	1.01810501165868	NA	0.645000545329154	0.614691217391805	0.833272017891657	NA	1.22868308945311	NA	0.619433005459456	0.605557919739048	NA	0.605557919739048	0.595528600673977	0.661130008440665	NA	0.896926077638306	NA	0.605278566269019	p.Lys223Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.035	-5.786	3.751	0.75	NA	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K223X	223	K	X	nonsense	low	-0.00622713232968951	0.00171712908007079	2	0.00121419361669068	-0.00860690808866166	-0.00384735657071735	NA	-0.00501293871299883	NA	NA	NA	NA	NA	-0.00744132594638018	0.298172397197348	NA	0.305912643035881	NA	NA	NA	NA	NA	0.290432151358814	p.Lys223Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K223Y	223	K	Y	missense	low	0.446952096634137	0.257697700406061	8	0.0911098957266524	0.268379982374699	0.625524210893576	0.731866574153283	0.49581208250132	0.552606537661772	0.542340476793487	-0.073505187145765	0.687215161674331	0.317111297474612	0.322169829960059	0.535163040928957	0.655317646094677	0.53678454915145	0.565079016627116	0.533541532706463	0.352672237243171	0.630051323534177	0.458381321899391	0.455978713967016	p.Lys223Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.1	67.9	25.4	0.685	24.8	175.7	-80.6	109.3	69.5652173913043	-1.2	0	1	43.02	0	0	0	0	6	22.6647236440244	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.035	-3.904	1.869	8.663	8.663	42.68	0.003036711	0	0.086794249	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.035	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224A	224	I	A	missense	possibly_low	0.618223559277311	0.376990365396139	8	0.133286221906802	0.356987364704566	0.879459753850057	0.940379957746355	0.968790639771079	0.729529179621794	0.793165746750512	0.129577734147688	-0.0460957083866326	0.600623808885798	0.829817115681894	0.647696251719426	0.754523417876222	0.754819704032285	0.651851162019184	0.643541341419668	0.428531390489958	0.268622422413077	0.611079287346592	0.71094357684468	p.Ile224Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.094	-2.805	0.711	10.206	10.206	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I224C	224	I	C	missense	wt-like	1.07341318825345	0.191772975620901	4	0.0958864878104503	0.885479125540933	1.26134725096598	1.18763360464041	0.78660495633161	1.16783359841084	NA	NA	NA	NA	1.15158059363096	0.86948977036865	0.872160897270811	0.670835170071394	0.866818643466488	NA	NA	NA	NA	0.872548658447099	p.Ile224Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.094	-3.892	1.798	14.151	14.151	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224D	224	I	D	missense	possibly_low	0.627911321175135	0.171716337065047	7	0.0649026748458655	0.500704415976925	0.755118226373345	NA	0.46401135955651	0.564176378789433	0.75297236281806	0.556258692173709	0.961505403969438	0.523375240490103	0.573079810428694	0.58199776413067	NA	0.522124951066035	0.570753473696999	0.625914470949784	0.587912868638045	0.765241493090396	0.569473718798599	0.58199776413067	p.Ile224Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.094	-3.666	1.572	10.435	10.435	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224E	224	I	E	missense	low	0.563006992392267	0.109798838463207	8	0.0388197516218699	0.486921677324612	0.639092307459923	0.427443719943955	0.634870442621916	0.413473717260627	0.516567933333641	0.744890158465503	0.606982332584164	0.560614160892158	0.599213474036176	0.590018554260477	0.510480400257664	0.600888112876172	0.49684098226979	0.522238944051334	0.658373856777557	0.590506753235518	0.589530355285435	0.595123345898921	p.Ile224Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.094	-3.269	1.175	10.836	10.836	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224F	224	I	F	missense	low	0.459652550825307	0.0671719900029664	8	0.0237488848184463	0.413105591908163	0.506199509742452	0.461114414789057	0.3907586654949	0.529015221532179	0.389638850916316	0.583055623671455	0.417589814801252	0.448696034496713	0.457351780900588	0.525186856201185	0.526500126238651	0.488356691914168	0.553508597541638	0.466573999333282	0.597922536216609	0.497160353533104	0.529251991864424	0.523873586163719	p.Ile224Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.094	-3.261	1.167	16.451	16.451	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I224G	224	I	G	missense	low	0.437601443152637	0.157790679885005	8	0.0557874298773615	0.328260089802955	0.546942796502319	0.607559685433351	0.484391784649267	0.437400479255884	0.532255877403229	0.119637410836312	0.30207909693575	0.460469381033424	0.55701782967388	0.530319450070822	0.596175347309242	0.53151998404023	0.508575921606062	0.529118916101414	0.424818303714381	0.440228275296807	0.535593038521279	0.573930665505546	p.Ile224Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.094	-3.35	1.256	13.031	13.031	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224H	224	I	H	missense	possibly_low	0.568451646417149	0.24227191802987	8	0.0856560580649963	0.400568857552084	0.736334435282213	0.703383626562342	0.521534365556201	0.655630373017023	0.787507517469097	0.476249173662768	0.0285549573127702	0.629929688935913	0.744823468821076	0.621235275535314	0.641766128442999	0.548642088745071	0.615607310356272	0.641059916247803	0.558026286904503	0.305415696825402	0.626863240714357	0.668255682854412	p.Ile224His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.094	-3.637	1.543	15.022	15.022	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224I	224	I	I	synonymous	wt-like	1.09042295030692	0.0958570198747451	5	0.0428685625120957	1.0064021117142	1.17444378889963	NA	NA	NA	1.19392863124019	1.04593801135036	1.17644809552409	0.96248134129807	1.07331867212186	0.819296522071002	NA	NA	NA	0.819296522071002	0.770826617753992	0.871180875669236	0.805973363470663	0.833241760434759	p.Ile224=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	NA	NA	NA	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
I224K	224	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile224Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.094	-3.151	1.057	11.275	11.275	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I224L	224	I	L	missense	wt-like	0.978022282416341	0.21197479820892	8	0.0749444086270887	0.831133940664595	1.12491062416809	1.16741604577793	0.9507562553813	1.17747146139918	1.25950255899701	0.780565505883469	0.680860825995507	0.80232009862712	1.00528550726921	0.772789195958811	0.862541857495384	0.746506156339333	0.871545557100768	0.848054069151724	0.671699948551672	0.626919445015097	0.719711576371328	0.79907223557829	p.Ile224Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.094	-2.202	0.108	20.593	20.593	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
I224M	224	I	M	missense	wt-like	0.865732972995297	0.0817093747714533	4	0.0408546873857266	0.78565925711963	0.945806688870964	NA	NA	NA	NA	0.837434490502122	0.858516306370285	0.787194861047702	0.979786234061079	0.713023101431458	NA	NA	NA	NA	0.692942665525109	0.714480979517727	0.711565223345189	0.786265275155473	p.Ile224Met	1	0	NA	NA	NA	NA	NA	NA	NA	2.162	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.094	-3.414	1.32	7.395	7.395	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.6	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
I224N	224	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile224Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.094	-3.548	1.454	10.61	10.61	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224P	224	I	P	missense	possibly_wt-like	0.735007754800893	0.276852699863872	5	0.123812291329993	0.492340122950726	0.977675386651061	0.877117315933378	0.758040380232019	0.72147629058898	0.288940301048433	NA	NA	NA	1.02946448620166	0.6576673812187	0.724424538380583	0.6576673812187	0.647901602764131	0.422412495091456	NA	NA	NA	0.811216080766527	p.Ile224Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.094	-3.253	1.159	20.501	20.501	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I224Q	224	I	Q	missense	possibly_wt-like	0.722813400945942	0.0956341265218175	5	0.0427688815743199	0.638987933401216	0.806638868490667	0.775456762939164	0.744472357718874	0.553200416777443	0.766438548560755	NA	NA	NA	0.774498918733472	0.651412751183976	0.676056834371656	0.651412751183976	0.565370286101725	0.631820087461416	NA	NA	NA	0.683160119912493	p.Ile224Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.094	-3.16	1.066	8.387	8.387	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224R	224	I	R	missense	possibly_wt-like	0.807751953033688	0.178425890531097	7	0.0674386476857883	0.675574632403458	0.939929273663919	0.692149542790281	0.732439940766507	0.632370675782511	0.879825254439366	1.16582943042818	NA	0.829525463143894	0.722123363885075	0.65685459925739	0.636421215173351	0.645866009469205	0.604199534574444	0.681546002076816	0.815610597986664	NA	0.734364205951177	0.65685459925739	p.Ile224Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.094	-3.775	1.681	21.769	21.769	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I224S	224	I	S	missense	possibly_wt-like	0.746883367884335	0.270418884946324	6	0.110398047488481	0.53050717084337	0.9632595649253	NA	0.304561294723083	0.66280216230914	0.982784362395167	1.03051907697826	NA	0.866056301920143	0.634577008980213	0.672911804813011	NA	0.448621154652095	0.619124732073937	0.726698877552085	0.765067062504414	NA	0.754039474352728	0.612884612612	p.Ile224Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.094	-2.843	0.749	10.423	10.423	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224T	224	I	T	missense	possibly_low	0.619655031090164	0.337561136401898	7	0.127586117028539	0.369590836786915	0.869719225393414	0.799121689615146	0.546782345593272	0.716609360565218	0.241156984211587	0.11128704684741	0.932977214046846	NA	0.989650576751671	0.645514604949966	0.687316050804622	0.560280982629791	0.645514604949966	0.401457047848696	0.421699126890126	0.751180727382888	NA	0.791219622105066	p.Ile224Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.094	-2.954	0.86	10.007	10.007	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I224V	224	I	V	missense	possibly_wt-like	0.745520916068854	0.403901941423078	7	0.152660584437377	0.446311668712758	1.04473016342495	NA	0.895942285852312	1.01098597882733	0.19158696925486	0.489048219008785	0.332061371699334	1.23821502794152	1.06080655989784	0.721237838881402	NA	0.721237838881402	0.789892342230408	0.379718041391791	0.562807214498671	0.45500571971136	0.954481705293524	0.826957576381706	p.Ile224Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.094	-2.088	-0.006	13.829	13.829	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.055	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.571428571428571
I224W	224	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile224Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.094	-5.659	3.565	0.982	NA	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I224X	224	I	X	nonsense	low	0.16439696382224	0.384353812193524	6	0.156911786761275	-0.143144486979688	0.471938414624167	NA	0.807494705395071	0.218504258481404	NA	-0.337507569626093	0.289232167571291	0.0455694797189276	-0.036911258607163	0.356674212047386	NA	0.680464992824385	0.40121773113144	NA	0.254057360804824	0.433896374662918	0.312130692963332	0.275630934941028	p.Ile224Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I224Y	224	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile224Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.1	65.3	27.9	0.589	63.2	25.5	-88.8	-16.1	30.8900523560209	-3	0	1	32.05	0	0	0	0	6	25.5897451698918	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.094	-3.134	1.04	11.341	11.341	42.68	0.003245928	0	0.092774036	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y225A	225	Y	A	missense	possibly_low	0.639993622741651	0.16194373893677	7	0.0612089799443801	0.520026226520231	0.75996101896307	0.405226636043179	0.548419276055828	0.556689391759103	NA	0.798810238583489	0.744563164589614	0.571595519624323	0.854651132536019	0.595444842543514	0.499910033420142	0.561035580024212	0.567081462472505	NA	0.678515046369954	0.658316587996215	0.595444842543514	0.723416413556315	p.Tyr225Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.226	-3.056	0.83	10.71	10.71	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y225C	225	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.226	-3.9	1.674	22.066	22.066	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
Y225D	225	Y	D	missense	low	0.413381156499417	0.0530554637310376	2	0.0375158781832136	0.339851386411926	0.486910926586908	NA	NA	NA	NA	0.375865278316203	NA	0.450897034682631	NA	0.525483270365483	NA	NA	NA	NA	0.520529104708661	NA	0.530437436022305	NA	p.Tyr225Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.226	-3.157	0.931	25.103	25.103	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
Y225E	225	Y	E	missense	low	0.295678576696762	0.232599290039472	8	0.0822362676430436	0.1344984538934	0.456858699500124	0.458331211994665	0.470950642961324	0.247969348721744	0.26272027681263	-0.0874218310821189	0.0597801224674399	0.635193493325733	0.317905348372677	0.434752921784259	0.525175943701854	0.525323843930575	0.415668957192731	0.410913663052371	0.347473844299417	0.320805727970364	0.62969829098017	0.453836886375788	p.Tyr225Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.226	-3.114	0.888	10.983	10.983	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y225F	225	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.226	-2.236	0.01	35.007	35.007	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.58	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
Y225G	225	Y	G	missense	low	0.464999799620604	0.0585812705019688	8	0.0207116068112328	0.424405796208633	0.505593803032575	0.458606730236077	0.418247126549169	0.454267603250962	0.470682325360674	0.544586239752239	0.358485814681714	0.494408095651937	0.520714461482057	0.521077736456795	0.525307028811636	0.50102840984151	0.516848444101955	0.50211573995559	0.583552766117525	0.468029606005401	0.553872205977928	0.555697369369895	p.Tyr225Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.226	-3.312	1.086	18.471	18.471	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y225H	225	Y	H	missense	possibly_wt-like	0.830331455107287	0.431119531478908	4	0.215559765739454	0.407842077742066	1.25282083247251	NA	NA	NA	NA	1.40664074528225	0.76452459936857	0.788179795937655	0.361980679840672	0.690125368410496	NA	NA	NA	NA	0.905562733403696	0.668155034051649	0.712095702769343	0.475973635965704	p.Tyr225His	1	0	NA	NA	NA	NA	NA	NA	NA	2.67	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.226	-2.826	0.6	31.801	31.801	86.35	0.003185237	0	0.091039391	3.229e-05	1	30966	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 13, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.175	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	T	B	0.285714285714286
Y225I	225	Y	I	missense	low	0.449163353417183	0.187595099697242	6	0.0765853787507971	0.299058769323262	0.599267937511105	NA	0.555853953362369	0.515739581807004	0.630416977106816	0.104783634031207	NA	0.509829751524629	0.378356222671076	0.554587867643856	NA	0.564462841140188	0.546997527349356	0.572167617662953	0.419269856194642	NA	0.562178207938355	0.484198220534031	p.Tyr225Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.226	-2.879	0.653	11.926	11.926	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y225K	225	Y	K	missense	low	0.538574480834962	0.142710203492786	6	0.0582611966076799	0.424384633787703	0.652764327882222	0.554963871885392	0.497230735789018	0.56315345453236	0.763282563240864	0.535019051532267	0.317797208029873	NA	NA	0.570701636104571	0.571151494232806	0.53743852444177	0.570251777976336	0.630436025235353	0.5799790594134	0.447975302993227	NA	NA	p.Tyr225Lys	0	0	NA	NA	NA	NA	NA	NA	NA	8.598	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.226	-2.995	0.769	10.175	10.175	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y225L	225	Y	L	missense	possibly_wt-like	0.956593205315638	0.409246985597879	7	0.154680821242117	0.65342436658201	1.25976204404927	1.1651231675492	0.679473292840965	0.836350615251749	1.03434525488415	1.65945922740996	0.972941545220454	NA	0.348459334052994	0.749310986419114	0.861450959873547	0.621449276180856	0.704241998154032	0.749310986419114	1	0.770878054791816	NA	0.469182566316282	p.Tyr225Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.226	-2.554	0.328	16.959	16.959	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.575	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y225M	225	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.226	-4.904	2.678	2.28	NA	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y225N	225	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.226	-3.054	0.828	10.688	10.688	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
Y225P	225	Y	P	missense	possibly_low	0.481620181073254	0.362655615180627	6	0.148053534924612	0.191440584837172	0.771799777309336	0.498404059010687	0.278062574884257	0.381050544918291	0.340078306786845	1.19293222523724	NA	NA	0.199193375602204	0.462889051940027	0.54424166335593	0.436405690768165	0.480938957557787	0.444839146322267	0.825734517082084	NA	NA	0.394214028713262	p.Tyr225Pro	0	0	NA	NA	NA	NA	NA	NA	NA	36.539	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.226	-4.479	2.253	1.637	NA	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y225Q	225	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.226	-3.801	1.575	5.415	5.415	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y225R	225	Y	R	missense	low	0.501945714023735	0.0795924891709984	3	0.0459527450483483	0.411879988738222	0.592011439309249	0.590269123636151	NA	NA	NA	0.47978845918256	NA	NA	0.435779559252495	0.559348343928895	0.587948904008244	NA	NA	NA	0.559348343928895	NA	NA	0.513038979756532	p.Tyr225Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.226	-3.096	0.87	13.147	13.147	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y225S	225	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.226	-2.832	0.606	8.077	8.077	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
Y225T	225	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.226	-3.224	0.998	10.007	10.007	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y225V	225	Y	V	missense	low	0.369319854757757	0.125054377240221	8	0.0442133990818104	0.282663184923312	0.455976524592202	0.569588139560849	0.385546667108979	0.450070562774432	0.448755674278434	0.25339330594932	0.214350919756936	0.235127737802813	0.397725830830293	0.489226910851934	0.578109377398306	0.485954048373893	0.514789995265722	0.492499773329975	0.474781190206333	0.396989452623334	0.414225518334706	0.493926568596184	p.Tyr225Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.226	-2.794	0.568	10.221	10.221	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y225W	225	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.226	-3.892	1.666	14.293	14.293	86.35	0.003185237	0	0.091039391	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y225X	225	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr225Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	44.3	62.8	27	0.973	51.7	-177.1	-155.5	139.9	22.3529411764706	-5.4	0	1	32	0	0	0	0	6	26.6343169212203	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S226A	226	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.182	-2.828	0.646	14.735	14.735	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.305	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
S226C	226	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.182	-3.37	1.188	14.751	14.751	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S226D	226	S	D	missense	possibly_wt-like	0.948659370745639	0.340564673554277	6	0.139034945770917	0.676155884442162	1.22116285704912	NA	1.28892540606142	1.08567077713367	1.10178499511207	0.375021058376205	1.13387579446384	NA	0.706678193326633	0.802704236946682	NA	0.902396443565203	0.826521685458727	0.778886788434637	0.52021375662624	0.850198151126881	NA	0.649097292354909	p.Ser226Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.182	-2.885	0.703	14.077	14.077	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.955	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S226E	226	S	E	missense	wt-like	1.160279744351	0.0535816590032824	3	0.0309353852491718	1.09964750341475	1.22091198528725	NA	1.10229551825176	1.20796320096652	1.17058051383472	NA	NA	NA	NA	0.816363206183655	NA	0.816363206183655	0.886500305852437	0.809057169198563	NA	NA	NA	NA	p.Ser226Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.182	-2.8	0.618	10.32	10.32	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.955	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S226F	226	S	F	missense	low	0.515485496198794	0.0977680178812849	2	0.0691324284270242	0.379988426318034	0.650982566079555	0.44635306777177	NA	NA	NA	NA	NA	NA	0.584617924625819	0.553634891754155	0.519477023941087	NA	NA	NA	NA	NA	NA	0.587792759567224	p.Ser226Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.182	-3.379	1.197	14.251	14.251	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	1.955	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S226G	226	S	G	missense	wt-like	0.890672316155957	0.21891604124946	8	0.0773985086390036	0.738974026766398	1.04237060554552	0.608724527986199	0.99986747834118	0.98026333880569	1.15127034933285	1.06378570402798	0.573261649803373	1.00983543555892	0.738370045391475	0.771984975692991	0.596729552044056	0.769145603603614	0.774824347782368	0.800588666795314	0.777493406104827	0.573886749605269	0.831477965765758	0.665014463476118	p.Ser226Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.182	-2.504	0.322	17.839	17.839	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S226H	226	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.182	-3.665	1.483	14.407	14.407	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S226I	226	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.182	-3.262	1.08	8.355	8.355	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S226K	226	S	K	missense	possibly_low	0.634275290086761	0.515122125388457	3	0.297405897758558	0.0513704416901862	1.21718013848333	NA	1.1937120865871	NA	NA	NA	0.179560728719226	NA	0.529553054953955	0.560136535767465	NA	0.858504705685716	NA	NA	NA	0.379842317581538	NA	0.560136535767465	p.Ser226Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.182	-2.817	0.635	12.65	12.65	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S226L	226	S	L	missense	low	0.498595002525863	0.0481074606235688	5	0.0215143104358389	0.456427728919404	0.540762276132321	0.495809247307419	0.453014589716978	0.453550982069678	0.525548120012021	NA	NA	NA	0.565052073523218	0.526177218759461	0.543007112876653	0.517055625240798	0.516496975479032	0.526177218759461	NA	NA	NA	0.577965848868064	p.Ser226Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.182	-3.189	1.007	14.443	14.443	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.305	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S226M	226	S	M	missense	possibly_wt-like	0.790928130815181	0.279054407909144	2	0.197321264152553	0.404185559692264	1.1776707019381	0.593606866662629	NA	NA	NA	NA	NA	NA	0.988249394967734	0.690026402521429	0.589536923766229	NA	NA	NA	NA	NA	NA	0.790515881276628	p.Ser226Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.182	-5.037	2.855	1.917	NA	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S226N	226	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.182	-2.932	0.75	8.959	8.959	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S226P	226	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.182	-3.273	1.091	18.783	18.783	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.305	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
S226Q	226	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.182	-3.171	0.989	9.077	9.077	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.305	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S226R	226	S	R	missense	possibly_low	0.700715550549017	0.495266462329144	6	0.202191686569958	0.304427126898488	1.09700397419955	NA	1.10932862831409	0.968386035428364	1.12185046595287	-0.0177939946199814	0.177767729929037	NA	0.844754438289728	0.743722456597897	NA	0.819605351558245	0.768999095095061	0.787686531596907	0.373482475073401	0.37895859744468	NA	0.718445818100733	p.Ser226Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.182	-3.134	0.952	11.866	11.866	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.305	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S226S	226	S	S	synonymous	wt-like	0.993691374646848	0.208047902175881	8	0.0735560412201004	0.849524183010107	1.13785856628359	0.569823725842776	1.04952120102835	1.01449041817975	1.04682610303399	1.1099369757209	1.30036272908237	0.952674158565119	0.905895685721529	0.791823118626024	0.578221463819412	0.792035134112143	0.791611103139905	0.75478448161079	0.794732651874927	0.932255014439428	0.800691279647848	0.74915389082381	p.Ser226=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S226T	226	S	T	missense	wt-like	1.18108214114975	0.211755369676198	4	0.105877684838099	0.973565692100592	1.3885985901989	1.41656738702281	1.14171564590021	0.912308522707959	1.25373700896802	NA	NA	NA	NA	0.840030399953415	0.981082215302066	0.834535221606225	0.741495740899728	0.845525578300605	NA	NA	NA	NA	p.Ser226Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.182	-2.345	0.163	22.333	22.333	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.29	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
S226V	226	S	V	missense	possibly_wt-like	0.781840210488565	0.317369531946671	8	0.112207074090746	0.561918386460086	1.00176203451704	0.885996656015167	0.533844795573542	0.398492480816454	0.339307899640529	1.16097078560466	0.898505445638918	1.11947690664285	0.918126713976402	0.731419827026825	0.728649119894467	0.554316989803957	0.489493397966926	0.444501283080893	0.813795710354105	0.734190534159184	0.890530137678106	0.755296900999511	p.Ser226Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.182	-2.816	0.634	10.756	10.756	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.955	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S226W	226	S	W	missense	low	0.471814643960672	0.11378291827276	3	0.0656925984939591	0.343059516861662	0.600569771059682	0.35573064222039	NA	NA	NA	0.476565642816989	NA	NA	0.583147646844636	0.55814450010488	0.47636100178164	NA	NA	NA	0.55814450010488	NA	NA	0.587054315408425	p.Ser226Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.182	-5.739	3.557	0.846	NA	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S226X	226	S	X	nonsense	low	-0.000570720367043571	0.0804630615108999	4	0.04023153075545	-0.079423071690641	0.0782816309565539	NA	0.110828913185293	0.0018634233526699	-0.0412388403133144	NA	NA	NA	-0.0737363776928225	0.286288811936646	NA	0.359313787193715	0.294965700100288	0.277611923773004	NA	NA	NA	0.257135590432728	p.Ser226Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S226Y	226	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser226Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.1	61.8	24.1	0.977	20.3	-150.1	-136.6	119.9	55.9440559440559	-0.9	0	1	34.5	0	0	0	0	4	26.8568240464132	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.182	-3.524	1.342	9.766	9.766	86.35	0.003139502	0	0.089732189	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S227A	227	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.051	-2.718	0.667	18.328	18.328	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.72	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
S227C	227	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.051	-2.94	0.889	19.668	19.668	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S227D	227	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.051	-2.894	0.843	16.046	16.046	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S227E	227	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.051	-2.874	0.823	12.31	12.31	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S227F	227	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Phe	1	0	yes	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.051	-3.057	1.006	14.251	14.251	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S227G	227	S	G	missense	wt-like	0.884512977867649	0.246848393152019	8	0.0872740863613977	0.713458911815672	1.05556704391963	1.11518880867637	1.06965770491459	0.807222707096928	1.03228239011503	0.339791276605907	0.91717443686885	0.978384313259383	0.816402185404141	0.745899141990637	0.837693364437549	0.801317723515221	0.689956143876839	0.748406313895315	0.507054100476217	0.743391970085959	0.814538599096312	0.704205954178349	p.Ser227Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.051	-2.734	0.683	19.736	19.736	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S227H	227	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.051	-4.145	2.094	10.278	10.278	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S227I	227	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.051	-3.246	1.195	9.837	9.837	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S227K	227	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.051	-2.599	0.548	9.9	9.9	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S227L	227	S	L	missense	possibly_low	0.593206630926918	0.325619683030774	6	0.132933678938698	0.332661407874659	0.853751853979178	NA	1.02658281738181	0.851859243313952	0.713074403800181	0.159109441170293	0.379307366229738	0.429306513665535	NA	0.56361304179249	NA	0.781460925293971	0.711848242974574	0.608417159531497	0.439562600177108	0.478291980126506	0.518808924053483	NA	p.Ser227Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.051	-2.818	0.767	17.145	17.145	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S227M	227	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.051	-3.682	1.631	4.582	4.582	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S227N	227	S	N	missense	low	-0.223486330182067	0.176611544134543	2	0.124883220493363	-0.468252944622432	0.0212802842582981	NA	NA	NA	-0.0986031096887043	-0.348369550675429	NA	NA	NA	0.251227367514119	NA	NA	NA	0.252454735028238	0.25	NA	NA	NA	p.Ser227Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.051	-3.081	1.03	12.103	12.103	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S227P	227	S	P	missense	low	0.186517999706154	0.2342700783671	3	0.13525589280832	-0.0785786788949633	0.451614678307271	-0.0832682404188079	NA	NA	0.338557784095978	NA	NA	NA	0.304264455441291	0.444172318752748	0.267495641616315	NA	NA	0.444172318752748	NA	NA	NA	0.446985774405723	p.Ser227Pro	1	0	NA	NA	NA	NA	NA	NA	NA	7.686	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.051	-3.42	1.369	15.223	15.223	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S227Q	227	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.051	-3.177	1.126	15.554	15.554	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.72	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
S227R	227	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.051	-4.265	2.214	5.275	NA	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S227S	227	S	S	synonymous	wt-like	1.09132753113372	0.367003426077997	6	0.149828521290723	0.797669025547008	1.38498603672043	NA	0.371333000748171	1.13887472812622	1.09515970355839	1.28035258658607	1.36318675586999	1.29905841191345	NA	0.855502511589546	NA	0.479401787391297	0.852615694228964	0.775981256612831	0.858389328950128	0.963219261517839	0.987251549901768	NA	p.Ser227=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S227T	227	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.051	-2.569	0.518	7.506	7.506	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
S227V	227	S	V	missense	low	0.512151811919969	0.149451321068628	8	0.0528390212924573	0.408589233208407	0.61571439063153	0.700472453191883	0.750628872736769	0.350945013587687	0.447440150006037	0.500020879931053	0.454293598536892	0.342356782709196	0.551056744660232	0.541078282289127	0.640381060511006	0.654250800995793	0.466173625586795	0.491922848132821	0.566905918422792	0.515250646155462	0.471978373446994	0.570936722140034	p.Ser227Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.051	-3.109	1.058	9.887	9.887	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S227W	227	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.051	-5.702	3.651	2.285	NA	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S227X	227	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser227Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S227Y	227	S	Y	missense	possibly_wt-like	0.9078646004307	0.256874399688586	3	0.148306503808129	0.617189194293716	1.19854000656768	0.848706739492648	NA	NA	NA	1.18915709396755	NA	NA	0.685729967831907	0.710907453222818	0.710907453222818	NA	NA	NA	0.82432436274862	NA	NA	0.638576086803305	p.Ser227Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.4	59.1	24.4	0.501	15.5	-116	-92.3	159	7.69230769230769	-3.1	0	0	40.78	2	12	0	0	5	28.9414498230479	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.051	-3.514	1.463	26.384	26.384	83.13	0.00265679	0	0.075935476	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N228A	228	N	A	missense	wt-like	1.04308288914671	0.0315098002575874	2	0.0222807934359737	0.999413336465226	1.0867524418282	1.02080209571074	NA	NA	NA	NA	NA	NA	1.06536368258268	0.811016382555843	0.792786382716161	NA	NA	NA	NA	NA	NA	0.829246382395525	p.Asn228Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.44	-2.739	0.299	9.056	9.056	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N228C	228	N	C	missense	wt-like	0.930588358321388	0.278792881846312	8	0.0985681686500334	0.737398297745252	1.12377841889752	0.731405186111976	0.779792569072659	1.0234818224839	1.15769875222458	0.376454832182013	1.13511377250059	1.10425009615742	1.13650983583797	0.799714406155849	0.655098128498541	0.667694774194491	0.79602095952072	0.803407852790979	0.520749325378961	0.850808316691997	0.882329078155892	0.864979399628569	p.Asn228Cys	0	0	NA	NA	NA	NA	NA	NA	NA	-0.969	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.44	-3.429	0.989	18.828	18.828	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N228D	228	N	D	missense	possibly_wt-like	0.879557208088326	0.354080029459494	8	0.12518619495677	0.634196774611446	1.12491764156521	1.27569418396594	0.936141055146488	0.877728607887614	0.759807213211647	0.204372456138394	1.33239770884142	0.690470502933782	0.959845936581314	0.732152365763611	0.914058053151073	0.739768794998459	0.724535936528763	0.628911905123807	0.456470048459848	0.948044181086838	0.659470123133682	0.776250299490944	p.Asn228Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.44	-2.486	0.046	16.538	16.538	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.625	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
N228E	228	N	E	missense	wt-like	1.01792135159936	0.144051593960279	8	0.0509299294650223	0.918100524112748	1.11774217908597	0.812236403970134	1.08703370232278	0.987100394042754	1.05096993776818	0.847354159251748	1.10350834441403	1.26111485293587	0.994053018089361	0.785804169035665	0.693555723946276	0.809327765890023	0.778177598358505	0.756601766719975	0.696648037040559	0.835230864332891	0.966815399733779	0.793430739712826	p.Asn228Glu	0	0	NA	NA	NA	NA	NA	NA	NA	0.255	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.44	-3.012	0.572	14.3	14.3	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N228F	228	N	F	missense	wt-like	1.08926502851095	0.176380838365169	5	0.0788799089025843	0.934663247958084	1.24386680906382	NA	1.17090013770085	1.06819364233414	1.27610114143406	0.804597048960911	NA	NA	1.12653317212478	0.847988781164194	NA	0.847988781164194	0.817949981661743	0.855333403061337	0.680676638947189	NA	NA	0.859968639663622	p.Asn228Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.44	-3.268	0.828	12.434	12.434	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N228G	228	N	G	missense	wt-like	0.982506670119119	0.0907527446608986	8	0.0320859405805063	0.919619382171234	1.045393958067	1.09459462201378	0.913252172826213	1.00718663279454	1.03209472549051	0.913501006158677	0.844681913818912	1.09607837559831	0.958663912252005	0.761990321676634	0.827895133998478	0.729217405458607	0.788028943613364	0.748324013285005	0.721356386538121	0.707662385246644	0.877927843454225	0.775656630068263	p.Asn228Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.44	-2.773	0.333	20.749	20.749	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N228H	228	N	H	missense	wt-like	1.062430459861	0.141025871788433	7	0.0533027693111819	0.957958951734833	1.16690196798716	NA	1.04952668443888	1.04154325390557	0.942042489264466	1.3465163082178	0.923857274819054	1.11307172278857	1.02045548559262	0.804879233034773	NA	0.792037661872115	0.804879233034773	0.708831466298974	0.883103981795735	0.7466857584032	0.887080347973959	0.806691327715438	p.Asn228His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.44	-4.157	1.717	14.671	14.671	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.714285714285714
N228I	228	N	I	missense	possibly_wt-like	0.790147229289977	0.236595792661487	7	0.0894248040894994	0.614877833950008	0.965416624629946	NA	1.17726416923748	0.840219529177575	0.467369260939946	0.650227559507099	0.820313492240526	0.616332623940954	0.959303969986254	0.695651855752653	NA	0.850922492598738	0.706139516515515	0.500662790447763	0.623013795205721	0.695651855752653	0.619539951345401	0.775978097821636	p.Asn228Ile	1	0	NA	NA	NA	NA	NA	NA	NA	1.509	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.44	-3.335	0.895	11.858	11.858	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	B	0.357142857142857
N228K	228	N	K	missense	possibly_wt-like	0.801465731199257	0.180939555685971	7	0.0683887238113718	0.667426295580311	0.935505166818203	0.949451774606702	0.857703705589093	0.584541582853689	0.523355364017801	0.935906095403468	NA	0.78835272914853	0.970948866775516	0.712188843454132	0.75883957532177	0.7036104969185	0.580741638176264	0.525215582238705	0.729725534902265	NA	0.712188843454132	0.781826724607607	p.Asn228Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.44	-2.409	-0.031	14.163	14.163	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.705	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
N228L	228	N	L	missense	wt-like	1.08963544298498	0.0965728316973208	8	0.0341436520857814	1.02271511459618	1.15655577137377	1.15740914663702	0.93349136295937	1.2400376316569	1.16676723644127	1.07617351868019	1.08471151671254	1.04021699548469	1.01827613530783	0.816675635910558	0.857780809857544	0.738547331493348	0.902231289362522	0.807384850520617	0.78212072347898	0.8259664213005	0.847841273207415	0.80559675326945	p.Asn228Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.44	-3.251	0.811	14.443	14.443	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N228M	228	N	M	missense	possibly_wt-like	0.918419408352738	0.226158351448125	4	0.113079175724063	0.696788296532099	1.14005052017338	NA	0.718392557866705	1.05247066428693	0.735437381210906	NA	NA	NA	1.16737703004642	0.724814505363452	NA	0.639390402363656	0.81023860836325	0.618224477740938	NA	NA	NA	0.880482387943743	p.Asn228Met	0	0	NA	NA	NA	NA	NA	NA	NA	1.87	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.44	-5.084	2.644	2.007	NA	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N228P	228	N	P	missense	wt-like	1.31990125985672	0.202417507557722	6	0.082636601420396	1.15793649726796	1.48186602244549	NA	1.37088584573519	1.36662196760814	1.2877256978531	1.65945922740996	1.14650429832562	NA	1.08821052220832	0.900305098545752	NA	0.940178826896757	0.964314888622822	0.860431370194747	1	0.856422395795707	NA	0.840721163205308	p.Asn228Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.44	-3.03	0.59	44.808	44.808	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.795	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N228Q	228	N	Q	missense	wt-like	1.07494836381411	0.0551249582571422	7	0.0208352757973164	1.03411197364341	1.11578475398481	NA	0.96239513182471	1.08556969280157	1.09392499337635	1.0881002698491	1.09161730909551	1.06133503710865	1.1416961126429	0.826472108399144	NA	0.751871482502587	0.826472108399144	0.775439772559552	0.786575816201186	0.829370097768766	0.859215310896819	0.867584197076731	p.Asn228Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.44	-2.994	0.554	10.67	10.67	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N228R	228	N	R	missense	possibly_wt-like	0.818817910983809	0.223039947774724	7	0.084301176320679	0.653590641540917	0.9840451804267	1.06725153507584	1.01509936901489	0.752750612391245	0.685631254065046	0.414471634855654	0.89566206678433	NA	0.900858904699655	0.732789110374481	0.81488593528027	0.776167248858192	0.663240170899903	0.596381923919591	0.534950039262751	0.732789110374481	NA	0.746624177342212	p.Asn228Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.44	-3.164	0.724	17.672	17.672	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N228S	228	N	S	missense	wt-like	1.0654640962378	0.11904543904058	8	0.0420889186074619	0.982971331618935	1.14795686085666	1.17255340512485	1.06793580336746	1.09207696127191	0.962682569296052	1.0200527678807	1.23856004946004	1.11034272135611	0.859508492145255	0.815093785062169	0.864986092441593	0.800523955880841	0.829663614243497	0.717883205207453	0.761157500140906	0.90179416148578	0.885610525833252	0.725856012982038	p.Asn228Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.44	-2.602	0.162	17.354	17.354	86.35	0.002957164	0	0.08452066	4.061e-06	1	246238	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Sep 19, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.91	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
N228T	228	N	T	missense	wt-like	1.07208201918805	0.180022123339795	7	0.0680419669781279	0.938722214473658	1.20544182390245	NA	1.20644431615267	1.07668140955422	1.3214677906265	1.02102223330956	0.98596706921058	1.13703881610492	0.75595249935791	0.822112827994556	NA	0.864374049237634	0.822112827994556	0.875229016984056	0.761519632151157	0.777297979839275	0.899988866080878	0.673845216817448	p.Asn228Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.44	-2.919	0.479	22.333	22.333	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.45	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
N228V	228	N	V	missense	possibly_wt-like	0.710809585650007	0.515330391806455	8	0.182196807298932	0.353710405245915	1.0679087660541	0.47773850520442	1.20264927227134	1.12861489644277	1.25232864243435	0.0883006097213636	0.156321351975098	0.243548003728621	1.1369754034221	0.68965870754618	0.534409478105679	0.862624597877255	0.847583734516676	0.844907936986681	0.413112823101327	0.368388263452119	0.418760617928708	0.865213230043084	p.Asn228Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.44	-3.197	0.757	17.036	17.036	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N228W	228	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn228Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.44	-3.636	1.196	19.467	19.467	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.05	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N228X	228	N	X	nonsense	low	0.0990233650107267	0.0702970686122301	6	0.0286986580855638	0.0427750287583924	0.155271701263061	NA	0.0502809282285122	0.0309815019408302	0.0821688015152656	0.21599272915548	NA	0.0649433504197857	0.149772878804486	0.331567360209059	NA	0.331402185124523	0.309246733442309	0.331732535293594	0.460810659999008	NA	0.322565331717485	0.369392680222332	p.Asn228Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N228Y	228	N	Y	missense	wt-like	0.92568202389792	0.227274007427663	5	0.101640026025409	0.726471233500404	1.12489281429544	NA	NA	0.756733764265674	1.12739538880141	1.16371562325548	NA	0.938701232009821	0.641864111157217	0.790118266058006	NA	NA	0.66519371754457	0.790118266058006	0.814821011047363	NA	0.793165553725853	0.61654454552131	p.Asn228Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38	56.6	22	0.352	55.1	-74	-79.4	170.8	64.1711229946524	-0.7	0	0	50.15	1	1	0	0	3	31.3911996881292	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.44	-3.409	0.969	14.492	14.492	86.35	0.002957164	0	0.08452066	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.05	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
S229A	229	S	A	missense	wt-like	1.09115370632022	0.319089761988857	6	0.130267849836472	0.835833412297266	1.34647400034318	NA	1.00482854278763	0.755679326700311	1.10826747353721	1.64525036590039	1.20435581161646	NA	0.828540717379324	0.776581130079863	NA	0.771432570820901	0.66467656604426	0.781729689338824	0.994692452738756	0.88493582677098	NA	0.7103025082773	p.Ser229Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.424	-2.749	0.325	25.875	25.875	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.11	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
S229C	229	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.424	-3.637	1.213	18.828	18.828	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S229D	229	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.424	-2.97	0.546	15.554	15.554	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S229E	229	S	E	missense	wt-like	1.13806060160773	0.0837769622178461	8	0.0296196290457241	1.08000719544268	1.19611400777279	1.06920654520006	1.14348306083138	1.22040304112469	1.23506081023488	0.998450406139013	1.19464935675334	1.17129625869826	1.07193533388023	0.836342536353494	0.815816083191505	0.83534997014468	0.892601456089063	0.837335102562308	0.753088200864444	0.880151780252388	0.918439698318895	0.832546981490774	p.Ser229Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.424	-2.754	0.33	14.079	14.079	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S229F	229	S	F	missense	wt-like	1.11514125785748	0.083978657606223	8	0.0296909391341518	1.05694808648737	1.17333442922759	1.10902866708548	1.16869210626511	0.998429811608407	1.08042426661811	1.23095783571104	1.07652238109235	1.03806319031075	1.21901180416857	0.837350517364084	0.834762513715755	0.846970915832514	0.783734139100398	0.769519008032316	0.839938521012413	0.821930219998738	0.846681247971162	0.906415852918455	p.Ser229Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.424	-3.136	0.712	13.773	13.773	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.31	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S229G	229	S	G	missense	wt-like	1.00277589392532	0.114357206294734	8	0.0404313780242776	0.92353184915241	1.08201993869823	1.17671334666043	0.932978930984028	1.09033064612363	1.06853055683327	0.808344647607299	0.922782204868411	1.01762952771249	1.00489729061299	0.781590128896268	0.866965294944049	0.738311108976719	0.828807129679009	0.764303003275512	0.682076508804354	0.746155885784706	0.835675812303237	0.798877254517024	p.Ser229Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.424	-3.378	0.954	13.537	13.537	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S229H	229	S	H	missense	possibly_wt-like	0.721795362948726	0.412234814590674	6	0.16829415832633	0.391944873820637	1.05164585207681	NA	0.985352632743361	0.948756564147838	1.05748113265796	0.498680885095322	-0.0181501647185354	NA	0.858651127766413	0.742398587979925	NA	0.762454504061469	0.759371772571197	0.759457261273984	0.56640537966283	0.282396017693824	NA	0.725425403388653	p.Ser229His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.424	-4.206	1.782	11.157	11.157	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S229I	229	S	I	missense	wt-like	1.01555710548718	0.114899260342236	4	0.0574496301711179	0.90295789942664	1.12815631154771	NA	0.92854723515368	1.03523810473346	NA	NA	0.928017431418412	NA	1.17042565064315	0.7752615215375	NA	0.736268171782416	0.801786857097922	NA	NA	0.748736185977078	NA	0.88201355171488	p.Ser229Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.424	-2.97	0.546	11.319	11.319	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.31	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S229K	229	S	K	missense	wt-like	0.86340669147209	0.0769252102131663	6	0.0314045855630984	0.80185483481901	0.924958548125169	NA	0.890156134651167	0.839316709374232	0.981722662655684	0.864494817667079	NA	0.860864102167188	0.74388572231719	0.712133623437984	NA	0.718570520556047	0.705696726319921	0.726233267495036	0.703050721349007	NA	0.751242989871231	0.667784701494909	p.Ser229Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.424	-2.665	0.241	20.145	20.145	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.11	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S229L	229	S	L	missense	wt-like	1.04071478813095	0.112295398280322	8	0.0397024188100298	0.962899477164166	1.11853009909773	0.93348699534247	1.1138341794995	1.19962111085493	1.18557745416731	1.03536608883822	0.95496713551407	0.981988172133031	0.92087716869807	0.791255852639917	0.751243908219072	0.82168233482828	0.882408907216192	0.815634100494801	0.766877604785033	0.762018959128965	0.81647961367456	0.756678311539241	p.Ser229Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.424	-2.878	0.454	34.011	34.011	58.31	0.002978071	0	0.085118234	4.061e-06	1	246240	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.655	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
S229M	229	S	M	missense	possibly_wt-like	0.911664648881148	0.237477899363053	3	0.137107929123845	0.642938045803541	1.18039125195875	NA	1.11357664707558	0.971392847590488	0.650024451977375	NA	NA	NA	NA	0.770473793523753	NA	0.821563616715011	0.770473793523753	0.580766505986606	NA	NA	NA	NA	p.Ser229Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.424	-3.945	1.521	6.471	6.471	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S229N	229	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.424	-3.031	0.607	13.125	13.125	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S229P	229	S	P	missense	possibly_wt-like	0.811970316495379	0.345562269471666	7	0.130610261072731	0.555978908781453	1.06796172420931	1.09520222723635	0.787147482433701	1.0033348632608	1.02471110687579	0.596724861984589	0.136999596425049	NA	1.03967207725137	0.745085915961837	0.828184218296113	0.671085265473983	0.786139833761192	0.745085915961837	0.603028513801324	0.358865097818963	NA	0.816342823537546	p.Ser229Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.424	-2.729	0.305	44.44	44.44	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	-0.415	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
S229Q	229	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.424	-2.777	0.353	7.75	7.75	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S229R	229	S	R	missense	possibly_low	0.695962527994205	0.267645904251197	8	0.0946271169264133	0.510496786857575	0.881428269130836	0.878057090731031	0.786925856906212	0.913791919040801	0.962598651054198	0.365975722317892	0.879061710129753	0.311245467973699	0.470043805800058	0.694414751284411	0.724871661162323	0.67098309983567	0.742223276283789	0.717846402733152	0.51683498144492	0.724607247935454	0.455222024886391	0.530248131008437	p.Ser229Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.424	-3.34	0.916	10.5	10.5	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S229S	229	S	S	synonymous	wt-like	1.14300133012874	0.26566876287018	6	0.1084588182714	0.930425952511017	1.35557670774646	NA	1.04475329393684	1.06401536751419	0.894773382666986	1.65945922740996	1.14505329575547	NA	1.04995341348898	0.818703670586939	NA	0.78983720918473	0.815900736487985	0.688101526749192	1	0.855707236255782	NA	0.821506604685893	p.Ser229=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S229T	229	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Thr	1	0	NA	NA	NA	NA	NA	NA	NA	-0.53	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.424	-2.65	0.226	12.57	12.57	58.31	0.002978071	0	0.085118234	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jul 2, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
S229V	229	S	V	missense	wt-like	0.96374561796996	0.152922292067185	8	0.0540661948576483	0.857777823267845	1.06971341267208	1.11152361858996	0.803946299236024	0.943136218277938	0.717749072076824	1.15232053446573	0.918166485157606	1.09693520034056	0.966187515615037	0.768025302669429	0.835949553057279	0.678829237303176	0.756615260100131	0.610467242508848	0.810564514335297	0.743880923594632	0.878389323599268	0.779435345238726	p.Ser229Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.424	-2.75	0.326	13.695	13.695	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S229W	229	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser229Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.424	-4.099	1.675	13.923	13.923	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S229X	229	S	X	nonsense	low	0.0310644726721357	0.0452970771120858	7	0.0171206858795278	-0.00249145504236229	0.0646204003866337	NA	0.0455426885670033	0.0108307656331196	0.0464992517175577	0.0256797382841302	-0.0283433543048441	0.00215574213045709	0.115086476677526	0.316089599255665	NA	0.329217936383051	0.299363755202333	0.316089599255665	0.389721558820958	0.277372072922908	0.288748340737601	0.351971502150938	p.Ser229Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	2	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S229Y	229	S	Y	missense	possibly_wt-like	0.832776101343155	0.333055437248253	3	0.192289646350347	0.45589531989653	1.20965688278978	NA	0.85375635317329	NA	NA	0.489726512992446	NA	NA	1.15484543786373	0.701790833887015	NA	0.701790833887015	NA	NA	0.563060582959816	NA	NA	0.874188420119303	p.Ser229Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.3	56.9	21.1	0.381	96.8	22.8	-69.8	141.5	35.6643356643357	-0.5	0	0	50.18	0	0	0	0	5	31.0688670192526	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.424	-3.577	1.153	14.334	14.334	58.31	0.002978071	0	0.085118234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.11	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
G230A	230	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-2.228	-2.614	0.386	26.019	26.019	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.33	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
G230C	230	G	C	missense	possibly_low	0.659865206174826	0.432879688374677	8	0.153046081543827	0.359900398373945	0.959830013975707	1.22184705853902	0.510136902212829	0.771818509426752	0.720293705718038	1.05348504571143	-0.0164247646039299	0.895774221531373	0.121990970863101	0.642087631733261	0.888438855264855	0.543388049958058	0.672592067952514	0.611583195514009	0.773645720574202	0.283246420289608	0.770045349505719	0.355439270939974	p.Gly230Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-2.228	-3.418	1.19	18.828	18.828	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G230D	230	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-2.228	-3.342	1.114	20.279	20.279	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G230E	230	G	E	missense	wt-like	1.00030270785019	0.21990467215743	5	0.0983443591027636	0.807551305926105	1.19305410977429	NA	0.827860825562414	0.740142848243845	0.996105470365047	NA	1.20140172018484	1.23600267489483	NA	0.732540869982855	NA	0.68985343146871	0.657056661929274	0.732540869982855	NA	0.883479835780616	0.953290146559843	NA	p.Gly230Glu	1	0	NA	NA	NA	NA	NA	NA	NA	7.658	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-2.228	-2.925	0.697	12.384	12.384	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	2	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.575	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	D	D	D	0.428571428571429
G230F	230	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-2.228	-3.089	0.861	16.356	16.356	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.575	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
G230G	230	G	G	synonymous	wt-like	1.00663446488052	0.166023169033318	7	0.062750859591	0.883645040083226	1.12962388967781	NA	1.14240461862525	0.993927514501227	0.699689742812073	1.07724250888699	1.02390094654479	1.20071977694991	0.908556145843369	0.782520031758575	NA	0.834852826437363	0.781525976398019	0.602547295826635	0.782520031758575	0.795994552002491	0.934287010844761	0.750490101750638	p.Gly230=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	0	-9.4	-9.4	0	97	97	0	9	9	0	75	75	0	3.29	3.29	0	NA	NA	NA	NA	NA	NA	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
G230H	230	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-2.228	-3.366	1.138	18.009	18.009	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.575	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
G230I	230	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-2.228	-3.152	0.924	14.341	10.443	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
G230K	230	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-2.228	-2.751	0.523	13.338	13.338	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G230L	230	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-2.228	-2.972	0.744	33.545	33.545	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.97	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G230M	230	G	M	missense	possibly_low	0.375464667637979	0.776497256019818	2	0.54906647530436	-0.700685849076918	1.45161518435288	NA	0.924531142942339	NA	NA	-0.173601807666382	NA	NA	NA	0.524849591961895	NA	0.734416820862048	NA	NA	0.315282363061743	NA	NA	NA	p.Gly230Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-2.228	-3.557	1.329	7.114	7.114	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G230N	230	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-2.228	-3.135	0.907	20.041	20.041	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
G230P	230	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-2.228	-3.842	1.614	13.013	13.013	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G230Q	230	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-2.228	-2.868	0.64	8.918	8.918	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.575	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
G230R	230	G	R	missense	possibly_wt-like	0.785968084240793	0.316852057372461	2	0.224048238400976	0.346841606175236	1.22509456230635	NA	1.01001632264177	0.561919845839817	NA	NA	NA	NA	NA	0.671735400790566	NA	0.773824050025612	0.56964675155552	NA	NA	NA	NA	NA	p.Gly230Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-2.228	-3.314	1.086	11.098	11.098	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	D	D	D	0.571428571428571
G230S	230	G	S	missense	possibly_low	0.626064320385394	0.299769331201169	6	0.122380316996373	0.386203306655908	0.86592533411488	0.788987800782475	0.193380912765334	0.540080959921238	0.419835001191586	1.02477698479792	NA	NA	0.789324262853816	0.620715200317704	0.682494584453304	0.397368869686368	0.558935816182105	0.479816567575007	0.762922173865372	NA	NA	0.690606120190783	p.Gly230Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-2.228	-2.712	0.484	19.755	19.755	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.225	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G230T	230	G	T	missense	wt-like	0.826235510374943	0.0839712460441898	3	0.0484808215078013	0.731214846278737	0.921256174471148	0.908527457879383	NA	NA	NA	NA	0.740680115390751	NA	0.829498957854695	0.710783782694161	0.739368746372539	NA	NA	NA	NA	0.656402739092233	NA	0.710783782694161	p.Gly230Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-2.228	-2.859	0.631	20.503	20.503	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.225	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
G230V	230	G	V	missense	wt-like	1.03908785592278	0.270879090988697	7	0.102382672874762	0.8384215044473	1.23975420739826	0.852647091945733	0.955476897481992	0.912760144866723	1.05456240772078	1.52851953411633	NA	1.24642662511567	0.723222290212216	0.748682292901427	0.712782180396027	0.748682292901427	0.741717240099539	0.758177249954428	0.951089071417801	NA	0.95890441727658	0.657406532869945	p.Gly230Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-2.228	-2.845	0.617	23.516	23.516	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.575	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
G230W	230	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-2.228	-3.81	1.582	18.112	18.112	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G230X	230	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G230Y	230	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly230Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.7	55.8	23.7	0.214	91.5	-67.2	85.8	152.5	18.5567010309278	-3.7	0	0	39.31	0	0	0	0	5	32.1219893197791	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-2.228	-3.23	1.002	17.327	17.327	58.31	0.002693934	0	0.076997119	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231A	231	P	A	missense	wt-like	1.00801662387151	0.067002653820183	7	0.0253246227413652	0.958381275376367	1.05765197236665	NA	1.06680787853155	1.01411029693453	1.08251144677894	0.902899487795709	0.932138947740018	1.01833201734522	1.03931629197458	0.7914246717392	NA	0.800004001513962	0.7914246717392	0.770434344108624	0.717396318399339	0.750767568813319	0.836054168577996	0.81616413107358	p.Pro231Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.407	-2.7	0.293	21.06	21.06	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
P231C	231	P	C	missense	wt-like	1.12399685076621	0.100809964596901	7	0.0381025851429464	1.04931715616816	1.19867654536425	1.09339710693833	1.06720814081848	1.05199937530177	1.1279902413365	1.34104992487489	NA	1.05709747967922	1.12923568641425	0.827325384444598	0.827325384444598	0.800188515691999	0.810007463520007	0.790379139554059	0.881062080836883	NA	0.856932990463343	0.86132597221443	p.Pro231Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.407	-3.988	1.581	13.551	13.551	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.5	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P231D	231	P	D	missense	wt-like	1.07070709948796	0.235896011248894	7	0.0891603115766671	0.895956099947322	1.2454580990286	0.75240383786465	1.09277351363908	0.813366295433952	1.11744789783893	1.46331825275463	NA	1.16655889079635	1.08908100808813	0.811973722308347	0.665088793930173	0.811973722308347	0.692969281904303	0.785755778565272	0.926733926419874	NA	0.915888183267246	0.841158363047054	p.Pro231Asp	0	0	NA	NA	NA	NA	NA	NA	NA	6.685	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.407	-2.896	0.489	16.538	16.538	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.155	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231E	231	P	E	missense	wt-like	1.04199900333107	0.283077632140445	6	0.115565959389895	0.815493885088053	1.26850412157408	1.30023011610669	1.25188051588708	0.983558472039289	1.23540911228419	0.557080784332544	NA	NA	0.9238350193366	0.806964152476672	0.925731673531973	0.885319372643997	0.776440453990508	0.837487850962837	0.58821995115716	NA	NA	0.758163886275237	p.Pro231Glu	0	0	NA	NA	NA	NA	NA	NA	NA	6.759	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.407	-2.511	0.104	16.217	16.217	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231F	231	P	F	missense	wt-like	0.98169470847384	0.124676390450951	3	0.0719819475884473	0.840612683663433	1.12277673328425	NA	0.837958152713882	1.06056685953773	1.04655911316991	NA	NA	NA	NA	0.754667392794413	NA	0.694508129351974	0.814209407259548	0.754667392794413	NA	NA	NA	NA	p.Pro231Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.407	-3.717	1.31	12.912	12.912	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P231G	231	P	G	missense	possibly_low	0.692840005335184	0.0721673084343668	8	0.025514996586961	0.642831530959079	0.74284847971129	0.807055395542456	0.694633224227571	0.646111070742228	0.759989739142329	0.60661413380565	0.602352423902788	0.724845550170517	0.701118505147937	0.62871485078357	0.691090721792373	0.628437749415122	0.61093854511589	0.628991952152018	0.606722530914112	0.588224797689351	0.677984296455606	0.646304949769824	p.Pro231Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.407	-2.755	0.348	24.544	24.544	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.525	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231H	231	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro231His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.407	-3.162	0.755	31.801	31.801	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	-0.45	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P231I	231	P	I	missense	possibly_low	0.677046594677842	0.375376458915665	6	0.153246797632699	0.376688390571655	0.97740479878403	NA	NA	0.769393979231452	1.21385014683083	0.896626487717568	0.23829520656099	0.675884810149025	0.268228937577189	0.661508658258669	NA	NA	0.671402951148223	0.828033133436448	0.715053115577487	0.408790937670185	0.651614365369115	0.428887005576728	p.Pro231Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.407	-2.993	0.586	13.88	13.88	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231K	231	P	K	missense	low	0.382134660197618	0.219231834884976	5	0.098043457126963	0.189973015308973	0.574296305086262	0.48697430941631	NA	NA	NA	0.00130416444689525	0.532806762412263	0.391536662248175	0.498051402464445	0.538803656882481	0.538803656882481	NA	NA	NA	0.380616359922793	0.553947640433832	0.498466331629725	0.544314892013402	p.Pro231Lys	0	0	NA	NA	NA	NA	NA	NA	NA	12.104	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.407	-2.458	0.051	17.532	17.532	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231L	231	P	L	missense	wt-like	0.993159686412865	0.227566517063222	5	0.101770840311246	0.793692504726446	1.19262686809928	NA	1.13313031156838	0.953675258362635	1.02240608731278	1.22555140440062	NA	NA	0.631035370419911	0.761784158260316	NA	0.83057752696664	0.761784158260316	0.744075046079969	0.837919014405538	NA	NA	0.611105831526614	p.Pro231Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.407	-2.969	0.562	29.631	29.631	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P231M	231	P	M	missense	wt-like	0.876426137021959	0.147385958314941	8	0.0521088052880861	0.7742947553799	0.978557518664018	0.528664746945043	0.943092203465274	0.878439230124262	0.947073541143716	0.984512707069795	0.958913987537162	0.92430783996019	0.84640483993023	0.733928810171588	0.558638988119634	0.742973157388658	0.724884462954517	0.711037841854509	0.747881943032099	0.763964254702553	0.785413367866672	0.719274729117888	p.Pro231Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.407	-5.036	2.629	3.933	NA	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P231N	231	P	N	missense	possibly_low	0.634043458462557	0.287047654771208	3	0.165727040752408	0.309224427323437	0.958862489601678	NA	NA	NA	NA	0.594642075072695	0.938756438225695	0.368731862089282	NA	0.602250514102859	NA	NA	NA	NA	0.602250514102859	0.754029149149935	0.48618381693801	NA	p.Pro231Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.407	-2.961	0.554	27.664	27.664	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231P	231	P	P	synonymous	wt-like	1.06374575245426	0.136277851279911	4	0.0681389256399554	0.930195912254696	1.19729559265383	NA	1.05903300583	NA	NA	1.23512923465669	NA	1.05924845683449	0.901572312495861	0.818958306179469	NA	0.796419916046228	NA	NA	0.84149669631271	NA	0.858091492547424	0.746982485021681	p.Pro231=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P231Q	231	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro231Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.407	-3.453	1.046	5.999	5.999	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231R	231	P	R	missense	possibly_low	0.626800223242524	0.21482442724626	5	0.0960724045100189	0.438501770494723	0.815098675990324	NA	0.623765072240994	0.547153693885767	0.388495874786002	0.97429641749738	NA	0.600290057802474	NA	0.595768724029053	NA	0.595768724029053	0.562404655970447	0.466072745389771	0.744065772418877	NA	0.610899531218244	NA	p.Pro231Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.407	-3.408	1.001	10.33	10.33	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P231S	231	P	S	missense	possibly_wt-like	0.730660804477591	0.157810399644819	8	0.0557944018653054	0.621305786282638	0.840015822672544	0.740341487439521	0.616165594292872	0.497297200479796	0.566528460488275	0.889875772560307	0.870397015027008	0.916527365370781	0.74815354016217	0.664639007775337	0.65934981083564	0.592265492590831	0.53795241601611	0.544149210234491	0.712531468102758	0.720336656352277	0.781222855659282	0.669928204715033	p.Pro231Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.407	-2.797	0.39	9.168	9.168	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.6	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P231T	231	P	T	missense	possibly_wt-like	0.752356835080624	0.049766598831654	2	0.035190299510453	0.683385115434958	0.821328554726289	0.717166535570171	NA	NA	NA	NA	NA	NA	0.787547134591077	0.669018636942173	0.648323712910502	NA	NA	NA	NA	NA	NA	0.689713560973843	p.Pro231Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.407	-3.017	0.61	8.97	8.97	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P231V	231	P	V	missense	possibly_wt-like	0.783206990529922	0.431923550922256	6	0.176332051275092	0.437602520710671	1.12881146034917	0.805775266503171	1.16509083016522	0.940105993922592	1.08487067147404	-0.0345837439413634	NA	NA	0.737982925055876	0.722805372778998	0.690481666454371	0.845310788158351	0.755129079103625	0.771468985734715	0.367210868585599	NA	NA	0.664820033039752	p.Pro231Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.407	-2.701	0.294	9.353	9.353	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P231W	231	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro231Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.407	-4.36	1.953	18.482	18.482	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.5	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P231X	231	P	X	nonsense	possibly_low	0.544204079242262	0.847603230035916	2	0.599345991714017	-0.630492478795653	1.71890063728018	NA	NA	NA	NA	1.14355007095628	NA	NA	-0.0551419124717553	0.536881519454538	NA	NA	NA	NA	0.807288414448752	NA	NA	0.266474624460324	p.Pro231Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P231Y	231	P	Y	missense	possibly_wt-like	0.735004562210742	0.153053738098722	3	0.0883656168917754	0.561811135631198	0.908197988790286	NA	NA	NA	NA	0.795265631312682	NA	0.848755574110352	0.560992481209192	0.677191001470249	NA	NA	NA	NA	0.677191001470249	NA	0.744721416662218	0.575926926516272	p.Pro231Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.9	55.3	27.6	0.302	32.9	-124.4	-73.5	155	24.025974025974	-0.4	0	0	28.23	0	0	0	0	6	32.6787933966357	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.407	-3.526	1.119	26.384	26.384	58.31	0.002898253	0	0.082836906	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T232A	232	T	A	missense	possibly_wt-like	0.768636082618879	0.356703217889006	4	0.178351608944503	0.419073352502882	1.11819881273488	0.838858862274261	0.260752575289263	0.880085803686958	1.09484708922503	NA	NA	NA	NA	0.715957046747227	0.706222064481698	0.428426072274532	0.725692029012757	0.775844159115133	NA	NA	NA	NA	p.Thr232Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.395	-2.717	0.322	11.285	11.285	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
T232C	232	T	C	missense	possibly_low	0.57736442786754	0.201417642052883	2	0.142423780546198	0.298218947454955	0.856509908280125	NA	NA	NA	NA	NA	0.434940647321341	NA	0.719788208413738	0.580696938494966	NA	NA	NA	NA	NA	0.505712105030734	NA	0.655681771959198	p.Thr232Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.395	-2.99	0.595	14.751	14.751	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T232D	232	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.395	-3.506	1.111	14.668	14.668	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T232E	232	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.395	-3.191	0.796	12.089	12.089	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T232F	232	T	F	missense	wt-like	0.994377456926859	0.105926815044047	5	0.0473719118157071	0.901530215889266	1.08722469796445	0.929485892686324	NA	NA	NA	1.11421564970909	0.848069433260072	1.05916787680195	1.02094843217686	0.796330898461572	0.749340277525731	NA	NA	NA	0.796330898461572	0.70933200106598	0.858048092674303	0.806938909179556	p.Thr232Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.395	-3.389	0.994	15.495	15.495	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.01	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T232G	232	T	G	missense	possibly_low	0.592969986059063	0.245473197022878	7	0.0927801475506422	0.411124238379492	0.774815733738634	0.729003298890799	0.541329487220167	0.475217307440647	NA	1.02248682826236	0.402032751863529	0.284805098104412	0.69591513063153	0.557767306688992	0.653955366957756	0.557767306688992	0.527123278106971	NA	0.762066713768167	0.489492702074746	0.440981416369273	0.643691565029295	p.Thr232Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.395	-3.238	0.843	20.369	20.369	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.56	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T232H	232	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.395	-3.719	1.324	15.022	15.022	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T232I	232	T	I	missense	possibly_wt-like	0.808228610448086	0.155513091695418	6	0.0634879538294044	0.683794507490311	0.93266271340586	NA	0.77526435279543	0.58133100589303	0.685580963979857	0.969783041351119	0.956119988234807	0.881292310434271	NA	0.70399359919827	NA	0.665607342698571	0.579167002800393	0.596359869125224	0.742379855697968	0.76258716875059	0.762245487872426	NA	p.Thr232Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.395	-2.909	0.514	21.426	21.426	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
T232K	232	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.395	-2.877	0.482	24.751	24.751	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
T232L	232	T	L	missense	possibly_wt-like	0.71519692073746	0.134804164131609	8	0.0476604692948224	0.621784117433331	0.808609724041588	0.663189148692139	0.952314415339174	0.563916436328215	0.891562458216558	0.676007052263286	0.613495153703258	0.682041758686338	0.67904894267071	0.633931982912291	0.622642539684535	0.747224441856768	0.570625984276829	0.686693370882759	0.632643410927026	0.593716744899868	0.654930457171664	0.635220554897556	p.Thr232Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.395	-2.489	0.094	14.629	14.629	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.865	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T232M	232	T	M	missense	wt-like	1.05183662247108	0.201060908309171	4	0.100530454154585	0.854800552978634	1.24887269196352	NA	0.953842358686463	0.921913813699066	1.35129523771843	NA	0.98029507978035	NA	NA	0.761215604588247	NA	0.747928798025255	0.746206679517759	0.888309889876479	NA	0.774502411151239	NA	NA	p.Thr232Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.395	-3.898	1.503	6.752	6.752	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.56	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T232N	232	T	N	missense	possibly_low	0.671957818731519	0.182063152760875	7	0.0688134035876625	0.537086026046082	0.806829611416957	0.84422947161359	0.657619451766042	0.348084562623019	0.50818595958428	0.762940646702122	0.807292408673766	NA	0.775352230157816	0.665116396940954	0.708777274297319	0.611375023235824	0.464770710367785	0.518563016545199	0.665116396940954	0.689234119268604	NA	0.683588693917357	p.Thr232Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.395	-2.81	0.415	13.125	13.125	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T232P	232	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.395	-3.646	1.251	42.967	42.967	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.56	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
T232Q	232	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.395	-3.011	0.616	6.529	6.529	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
T232R	232	T	R	missense	low	0.571825898000745	0.142023828669399	8	0.0502130061711043	0.473410214349893	0.670241581651597	0.837073833315149	0.537251173923442	0.513381948407903	0.677960346510387	0.61972668685755	0.568025098125267	0.392387868869779	0.428800227996481	0.56359653459443	0.705372789617468	0.555887272895416	0.545841220243485	0.593017835589042	0.611620565495678	0.571305796293444	0.498924785892103	0.50953362419428	p.Thr232Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.395	-3.185	0.79	12.805	12.805	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.56	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.5
T232S	232	T	S	missense	wt-like	1.1246392848855	0.122349319553865	5	0.0547162791046574	1.01739734847233	1.23188122129867	NA	1.02558864877594	1.1470922591047	1.09271543797972	NA	1.32493885001418	NA	1.03286122855298	0.812922088012492	NA	0.781002630298081	0.85664600253167	0.774909320176185	NA	0.944367913272449	NA	0.812922088012492	p.Thr232Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.395	-2.614	0.219	19.919	19.919	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.01	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
T232V	232	T	V	missense	possibly_wt-like	0.730843936619894	0.112894558015165	6	0.0460890103123645	0.640511136324564	0.821176736915224	NA	0.818141659576213	0.743127781964383	0.842993632335852	0.522825739117307	0.735991069706762	NA	0.721983737018847	0.657652550978772	NA	0.685373059518349	0.658520630022418	0.665393437438182	0.575424395982417	0.65409163653251	NA	0.656784471935126	p.Thr232Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.395	-2.529	0.134	13.91	13.695	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.24	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T232W	232	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.395	-4.06	1.665	15.032	15.032	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T232X	232	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr232Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T232Y	232	T	Y	missense	possibly_low	0.682948586110864	0.165915578933982	3	0.0957914041602869	0.495200883928181	0.870696288293547	NA	0.541579904740036	0.6416545749661	NA	NA	NA	NA	0.865611278626456	0.608752845789103	NA	0.557882744951235	0.608752845789103	NA	NA	NA	NA	0.728921125634297	p.Thr232Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.9	52.7	29.3	0.801	100.1	15.9	-69.1	-25.6	44.7852760736196	-2.2	0	0	31.21	0	0	0	0	5	35.3015883192244	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.395	-3.394	0.999	9.766	9.766	86.35	0.002932724	0	0.083822132	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.56	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
R233A	233	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.289	-2.89	0.601	14.447	14.447	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R233C	233	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.289	-3.604	1.315	13.791	13.791	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R233D	233	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.289	-3.071	0.782	15.062	15.062	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R233E	233	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.289	-2.885	0.596	21.598	21.598	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R233F	233	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.289	-3.256	0.967	15.686	15.686	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R233G	233	R	G	missense	possibly_wt-like	0.810825981279141	0.182974212493096	7	0.0691577517992314	0.675279278500887	0.946372684057394	0.843735897731676	0.903870859809357	0.934211483177147	1.00523262463825	0.535558689697815	0.57141808722893	NA	0.881754226670804	0.724892778041197	0.708542443433981	0.724892778041197	0.752238101794263	0.7365435975562	0.58018063468146	0.572978107960051	NA	0.737028889923268	p.Arg233Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.289	-3.22	0.931	15.561	15.561	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.714285714285714
R233H	233	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.289	-3.689	1.4	10.718	10.718	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
R233I	233	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.289	-3.303	1.014	13.543	13.543	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.02	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R233K	233	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.289	-2.277	-0.012	15.126	15.126	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.44	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R233L	233	R	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.289	-2.983	0.694	15.934	15.934	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
R233M	233	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.289	-4.171	1.882	4.461	4.461	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R233N	233	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.289	-2.976	0.687	10.217	10.217	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R233P	233	R	P	missense	low	0.491923346824703	0.0776489172911532	3	0.0448306233003303	0.404056939751574	0.579789753897833	NA	0.574952270741695	0.421100137001822	NA	NA	NA	NA	0.479717632730592	0.535106791787719	NA	0.573266844035798	0.500581378610658	NA	NA	NA	NA	0.535106791787719	p.Arg233Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.289	-3.457	1.168	16.941	16.941	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R233Q	233	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.289	-2.841	0.552	8.865	8.865	72.7	0.002777386	0	0.079382312	4.061e-06	1	246220	PTEN hamartoma tumor syndrome|Glioblastoma|Transitional cell carcinoma of the bladder|Colorectal Neoplasms|Uterine cervical neoplasms|Adenocarcinoma of stomach|Malignant neoplasm of body of uterus|Adenocarcinoma of prostate|Uterine Carcinosarcoma	Conflicting interpretations of pathogenicity(Last reviewed: Jul 12, 2016)	criteria provided, conflicting interpretations	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.02	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
R233R	233	R	R	synonymous	possibly_wt-like	0.953665714615671	0.53960697277167	4	0.269803486385835	0.424860598396093	1.48247083083525	1.15626470876604	0.162724965422524	NA	1.37787586248077	NA	NA	NA	1.11779732179335	0.856408694499977	0.857236313191234	0.383236993887407	NA	0.899966863832239	NA	NA	NA	0.855581075808719	p.Arg233=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R233S	233	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.289	-2.602	0.313	11.296	11.296	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R233T	233	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.289	-2.619	0.33	9.641	9.641	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R233V	233	R	V	missense	wt-like	1.07065988763758	0.0849548080119111	6	0.0346826551375484	1.00268313267976	1.1386366425954	NA	0.969247769983598	0.964880592916868	1.10183907919178	1.17631265440349	NA	1.10707345507852	1.10460577425122	0.799218492894005	NA	0.755030433366956	0.767279842183725	0.778910507091152	0.819526478696858	NA	0.883849720616551	0.848955646687314	p.Arg233Val	0	0	NA	NA	NA	NA	NA	NA	NA	-0.498	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.289	-3.047	0.758	11.157	11.157	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R233W	233	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.289	-5.729	3.44	0.771	NA	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R233X	233	R	X	nonsense	possibly_low	0.28990437695214	0.564092838034846	4	0.282046419017423	-0.262896446290502	0.842705200194782	NA	0	NA	NA	1.1337585131923	0.0631174980321946	NA	-0.0372585034159349	0.315337076329738	NA	0.308223523417026	NA	NA	0.803630897232575	0.32245062924245	NA	0.275456531910531	p.Arg233Ter	1	0	yes	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	17	29	3	15	3	10	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R233Y	233	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg233Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.6	51.6	30.9	0.925	62	-158.6	-157	126.7	37.3584905660377	-4.1	0	1	25.28	0	0	1	2	6	36.8739091751878	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.289	-3.245	0.956	8.9	8.9	72.7	0.002777386	0	0.079382312	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R234A	234	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.322	-3.001	0.679	25.804	25.804	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234C	234	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.322	-5.498	3.176	1.909	NA	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R234D	234	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.322	-3.042	0.72	18.113	18.113	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234E	234	R	E	missense	possibly_wt-like	0.956611412964947	0.241547476592797	2	0.170799858677266	0.621849841392975	1.29137298453692	NA	1.12741127164221	NA	NA	0.785811554287681	NA	NA	NA	0.750800345942886	NA	0.827941145809599	NA	NA	0.673659546076173	NA	NA	NA	p.Arg234Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.322	-2.507	0.185	16.29	16.29	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R234F	234	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.322	-3.227	0.905	14.634	14.634	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234G	234	R	G	missense	possibly_wt-like	0.746674483151565	0.261093151387845	6	0.10659083270591	0.537760289965847	0.955588676337283	0.658163192093227	0.723860485334202	0.67676961773455	0.593111187140666	1.26619458021523	NA	NA	0.561947836391514	0.623113206264923	0.620251307549966	0.641911024903364	0.625975104979881	0.55580710597737	0.853100778006927	NA	NA	0.576406751800305	p.Arg234Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.322	-3.09	0.768	26.062	26.062	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R234H	234	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.322	-3.495	1.173	13.88	13.88	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234I	234	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.322	-3.414	1.092	24.256	24.256	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234K	234	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.322	-2.358	0.036	20.763	20.763	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.465	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
R234L	234	R	L	missense	possibly_wt-like	0.897478842756227	0.316746983269306	4	0.158373491634653	0.587072503046452	1.207885182466	0.908410182991529	NA	NA	NA	0.823715517292842	NA	1.31194281060576	0.545846860134784	0.713565529904988	0.739312949734646	NA	NA	NA	0.68781811007533	NA	0.994191001908778	0.568320067760113	p.Arg234Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.322	-2.784	0.462	14.971	13.884	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R234M	234	R	M	missense	possibly_wt-like	0.839355830719334	0.265208903488977	3	0.153118431820847	0.539249218981223	1.13946244245744	NA	0.881307463961715	1.08108861281742	0.555671415378862	NA	NA	NA	NA	0.714491432287435	NA	0.714491432287435	0.824274351687002	0.539387836368809	NA	NA	NA	NA	p.Arg234Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.322	-3.531	1.209	4.542	4.542	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234N	234	R	N	missense	possibly_wt-like	0.810776757440264	0.364917459515617	6	0.148976929007667	0.518787342057857	1.10276617282267	NA	0.805830473228594	0.737896703143646	0.137033117857949	1.16788953984273	NA	0.983210976819141	1.03279973374952	0.746294506085438	NA	0.679697809803933	0.655955034534121	0.355793365782922	0.816380126782034	NA	0.817138208199292	0.812891202366942	p.Arg234Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.322	-2.89	0.568	11.631	11.631	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R234P	234	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.322	-3.301	0.979	14.118	14.118	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
R234Q	234	R	Q	missense	wt-like	1.2400258748894	0.107835448223225	2	0.0762511766909335	1.09057631479637	1.38947543498243	1.31627705158033	NA	NA	NA	NA	NA	NA	1.16377469819846	0.906019776201275	0.933366428629986	NA	NA	NA	NA	NA	NA	0.878673123772564	p.Arg234Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.322	-2.813	0.491	15.448	15.448	42.68	0.003017596	0	0.086247905	0	NA	NA	Glioma susceptibility 2|Meningioma	Pathogenic, risk factor(Last reviewed: May 20, 2002)	no assertion criteria provided	1	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.785	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
R234R	234	R	R	synonymous	possibly_low	0.685865309868725	0.291275541930965	8	0.102981455446586	0.4840253661179	0.887705253619549	1.01875621789593	0.713327686527479	0.448994403502332	0.399582120565983	0.295807889265365	0.637756538854083	0.918474863932085	1.05422275840654	0.621365050488852	0.791813002091421	0.637055581915824	0.514262190300856	0.470934635562776	0.490624641517639	0.605674519061881	0.78227176551706	0.823650874875254	p.Arg234=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R234S	234	R	S	missense	wt-like	1.21466004884964	0.141699846184006	5	0.0633700976937405	1.09045693967312	1.33886315802616	1.30825823934058	1.27109978833135	1.19226593115557	1.32364056205762	NA	NA	NA	0.978035723363076	0.878801541221723	0.929551266057169	0.894179133788926	0.878801541221723	0.876181889243866	NA	NA	NA	0.785386084558704	p.Arg234Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.322	-2.811	0.489	15.989	15.989	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R234T	234	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.322	-3.274	0.952	8.909	8.909	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R234V	234	R	V	missense	wt-like	1.01906328176002	0.356048163466594	6	0.145356054058035	0.734170650871413	1.30395591264862	NA	1.2489286874179	1.23562343017499	NA	0.334246867466312	0.957937477135575	1.25978883191189	1.07785439645344	0.85973922428245	NA	0.883958629397676	0.900066333376476	NA	0.504983053930774	0.763482959394126	0.966101213571434	0.835519819167224	p.Arg234Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.322	-3.037	0.715	15.747	9.219	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.235	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R234W	234	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Trp	1	0	NA	NA	NA	NA	NA	NA	NA	-3.55	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.322	-4.032	1.71	31.912	31.912	42.68	0.003017596	0	0.086247905	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome|Neoplasm	Conflicting interpretations of pathogenicity(Last reviewed: Dec 21, 2016)	criteria provided, conflicting interpretations	0	0	1	0	0	4	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.69	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
R234X	234	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R234Y	234	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg234Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	26.9	52.2	30.3	0.905	15.9	169.8	-104.5	124.8	47.5471698113208	-0.8	0	1	21.81	0	0	0	0	4	36.8374271340983	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.322	-3.213	0.891	8.9	8.9	42.68	0.003017596	0	0.086247905	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E235A	235	E	A	missense	possibly_wt-like	0.735318809042148	0.244575734632458	7	0.0924409386512015	0.554137898588716	0.916499719495579	0.406621082447982	0.84139105656977	0.876461726562358	0.957806088068553	0.382817817594454	0.732517362321292	0.949616529730626	NA	0.696090640255281	0.500573478276355	0.696090640255281	0.723914591463305	0.715744616849468	0.523126141127105	0.652379541029217	0.799044460959686	NA	p.Glu235Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.172	-2.679	0.507	11.069	11.069	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.685	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
E235C	235	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu235Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.172	-3.748	1.576	35.138	35.138	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.685	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E235D	235	E	D	missense	possibly_wt-like	0.980104368153331	0.363076552721619	4	0.181538276360809	0.624295884670666	1.335912851636	NA	1.34358105464592	1.00480977548734	NA	0.479904336032417	NA	NA	1.09212230644766	0.814774528666604	NA	0.927591777732193	0.786863208094426	NA	0.559391628315662	NA	NA	0.842685849238782	p.Glu235Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.172	-2.557	0.385	20.377	20.377	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
E235E	235	E	E	synonymous	wt-like	1.07215744053963	0.300073671846672	5	0.134197025701425	0.809136103332442	1.33517877774682	1.04584999777017	NA	NA	NA	1.39147757404925	0.584175490540711	1.18354378552731	1.15574035481071	0.87463789041707	0.804703586362736	NA	NA	NA	0.899898715361482	0.579265883647533	0.925036135348243	0.87463789041707	p.Glu235=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E235F	235	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu235Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.172	-4.632	2.46	4.692	NA	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E235G	235	E	G	missense	wt-like	1.00152323283396	0.221451788730388	8	0.0782950307585741	0.8480677923787	1.15497867328922	0.488545242089106	1.17114407497883	1.04004158843791	1.05085755490957	1.19958866436096	0.952435784815194	1.06308213843054	1.04649081464959	0.811955129327654	0.539551069760906	0.848101232143987	0.804142737508551	0.756552481044127	0.828220948892046	0.760771325500718	0.860156288125496	0.819767521146757	p.Glu235Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.172	-2.609	0.437	27.833	27.833	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.365	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
E235H	235	E	H	missense	possibly_wt-like	0.779972469882259	0.249196681673236	6	0.101734119282366	0.58057726008992	0.979367679674599	0.86713124983294	0.706313950599149	0.835965366420257	0.919499265905396	0.319776466901797	NA	NA	1.03114851963402	0.701499076433553	0.719673402614215	0.633822367690946	0.704053051916015	0.69894510095109	0.499577811939106	NA	NA	0.812061883285796	p.Glu235His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.172	-3.649	1.477	14.407	14.407	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E235I	235	E	I	missense	possibly_wt-like	0.798281067832798	0.180476580498465	3	0.104198202333212	0.594056344005886	1.00250579165971	0.615912921601173	0.802125627906407	NA	NA	NA	NA	NA	0.976804653990815	0.677989938461318	0.600149620934381	0.677989938461318	NA	NA	NA	NA	NA	0.784767782358495	p.Glu235Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.172	-3.578	1.406	17.181	17.181	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235K	235	E	K	missense	possibly_wt-like	0.840447905508575	0.198247770965596	2	0.14018234320489	0.565695561558557	1.11520024945859	NA	NA	NA	NA	0.700265562303685	NA	0.980630248713465	NA	0.728726563580781	NA	NA	NA	NA	0.641704882068828	NA	0.815748245092734	NA	p.Glu235Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.172	-2.791	0.619	20.007	20.007	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.88	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
E235L	235	E	L	missense	possibly_wt-like	0.754395302318512	0.230559870678363	7	0.0871434400180231	0.58359729839426	0.925193306242763	0.535321846350392	0.903221813894197	0.795582247695216	0.88820089147413	0.949241815235411	0.334079901866494	NA	0.875118599713741	0.685219150606999	0.561806279700413	0.724593578797464	0.684247051900561	0.685219150606999	0.734706930718045	0.45600059810466	NA	0.733696159177334	p.Glu235Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.172	-2.981	0.809	13.232	13.232	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E235M	235	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu235Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.172	-3.902	1.73	4.461	4.461	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.685	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235N	235	E	N	missense	wt-like	0.988186513149885	0.143599802570703	7	0.0542756237028648	0.881808245453821	1.09456478084595	0.874285778344156	1.08308573542901	0.893804795352341	1.11430423751445	0.951348098653576	NA	1.19425525446263	0.806221692293025	0.735493707250419	0.723077359283363	0.80750781959454	0.732420542255794	0.784377121484943	0.735493707250419	NA	0.930805261744932	0.699092821294339	p.Glu235Asn	0	0	NA	NA	NA	NA	NA	NA	NA	-1.167	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.172	-2.851	0.679	17.369	17.369	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235P	235	E	P	missense	low	0.427235883780256	0.163802787504092	8	0.0579130309107014	0.313728428959727	0.540743338600786	0.610924002105487	0.530847533996303	0.535400862394967	0.471463378739313	0.307218207889082	0.0879851352761535	0.436786033648681	0.437261916192065	0.518310417373771	0.597776010183852	0.552935302659441	0.556640450826378	0.502458272118556	0.4948868271488	0.334707208504414	0.522837344098381	0.513783490649161	p.Glu235Pro	0	0	NA	NA	NA	NA	NA	NA	NA	4.581	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.172	-3.566	1.394	17.923	17.923	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E235Q	235	E	Q	missense	possibly_low	0.669092675009312	0.509378306191256	5	0.22780090378147	0.222611107951956	1.11557424206667	NA	NA	0.203767223136516	0.0348046980448471	1.13840774104256	0.97645157052772	0.99203214229491	NA	0.772608050406919	NA	NA	0.393989915859025	0.310960934718775	0.805367559703875	0.772608050406919	0.821889229642115	NA	p.Glu235Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.172	-2.676	0.504	10.935	10.935	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.685	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
E235R	235	E	R	missense	wt-like	0.816756522101377	0.131275466181011	8	0.046412886170009	0.725788936789602	0.907724107413152	0.874098611636659	0.796349006976049	1.00436430594471	0.91049163723602	0.640404994062116	0.898059201091574	0.633310095043681	0.776974324820206	0.689699089662638	0.722988309758824	0.675327013430405	0.78664472646035	0.694994791515519	0.619344695447742	0.733970592408744	0.62868390510928	0.684403387809756	p.Glu235Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.172	-3.109	0.937	14.598	14.598	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.685	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235S	235	E	S	missense	wt-like	1.0357327127046	0.345588820780253	6	0.141086045286961	0.759209145220969	1.31225628018823	NA	1.30701202714809	1.06704148185975	1.3027887303324	0.370969064447786	1.03413981049441	NA	1.13244516194516	0.84016141339189	NA	0.910734071496303	0.817384901720072	0.867037286303788	0.518700183616687	0.801041008419714	NA	0.862937925063709	p.Glu235Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.172	-2.545	0.373	8.459	8.459	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235T	235	E	T	missense	wt-like	0.915134973887983	0.154416093564844	4	0.0772080467824222	0.763809982877751	1.06645996489821	NA	1.05694856185206	0.82148687796502	0.747017556794004	NA	NA	NA	1.03508689894084	0.746205532027464	NA	0.795459022452669	0.696952041602259	0.623302981590348	NA	NA	NA	0.814039926640242	p.Glu235Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.172	-2.575	0.403	9.763	9.763	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.34	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E235V	235	E	V	missense	wt-like	1.16033188593342	0.166080220019705	6	0.0678019659029068	1.02744247468271	1.29322129718413	NA	1.17187302840593	1.25402336093432	1.31495029191121	1.18091441207268	1.20087728532602	0.839352936950373	NA	0.860404012641785	NA	0.848437267405915	0.909090624724181	0.872370757877655	0.821245409259845	0.88322135616103	0.739657218412128	NA	p.Glu235Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.172	-3.261	1.089	12.292	12.292	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.685	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E235W	235	E	W	missense	possibly_low	0.685197583838643	0.311599568913957	4	0.155799784456979	0.379835617503862	0.990559550173425	NA	0.276786941104297	NA	NA	1.02735859757506	0.667258933163877	0.769385863511343	NA	0.661094429222224	NA	0.435817645063958	NA	NA	0.763886503893902	0.620215443506304	0.701973414938144	NA	p.Glu235Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.172	-5.777	3.605	0.982	NA	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.685	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E235X	235	E	X	nonsense	low	0.174778058894012	0.30123509093535	2	0.213005375531732	-0.242704805661612	0.592260923449636	0.387783434425744	NA	NA	NA	NA	NA	NA	-0.0382273166377202	0.38329045751458	0.491610967676833	NA	NA	NA	NA	NA	NA	0.274969947352327	p.Glu235Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	1	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E235Y	235	E	Y	missense	possibly_low	0.676647530791601	0.403841679967892	5	0.180603489711184	0.32267119547543	1.03062386610777	1.07506653951315	0.143325652024277	0.488679481079278	0.591377017993445	NA	NA	NA	1.08478896334785	0.555046583425143	0.818604130886327	0.374294236892704	0.533725834316416	0.555046583425143	NA	NA	NA	0.839002691915842	p.Glu235Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	51.6	33.3	0.6	59.3	-83.4	-134.1	68.4	39.7196261682243	-4.7	0	1	29.61	1	5	1	2	4	38.5219685096699	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.172	-3.542	1.37	11.341	11.341	72.21	0.002719649	0	0.077732096	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.135	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D236A	236	D	A	missense	wt-like	0.894137561379933	0.0871548693344258	7	0.0329414442581743	0.829573517035178	0.958701605724689	NA	0.931434444075178	0.928350179708362	0.994998607505261	0.812087817615657	0.864407003438065	0.755699799735855	0.971985077581153	0.732055453569792	NA	0.737599126504773	0.749363411075506	0.732055453569792	0.68347472439769	0.717384343227402	0.694602191414021	0.782347159471346	p.Asp236Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.146	-2.777	0.631	14.735	14.735	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.095	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
D236C	236	D	C	missense	possibly_low	0.624439115947444	0.177482821494502	6	0.0724570584618335	0.482425890936537	0.766452340958351	NA	NA	0.799828000612628	0.57751475310531	0.723394388596155	0.548444471105775	0.327926311358775	0.76952677090602	0.605999706790156	NA	NA	0.686329391873371	0.548967265793838	0.65034437359753	0.561655039982782	0.464206216921395	0.68066286832721	p.Asp236Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.146	-3.587	1.441	13.911	13.911	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D236D	236	D	D	synonymous	wt-like	0.941609669314936	0.302831982896113	7	0.114459730825669	0.717272719216477	1.1659466194134	0.601549410930318	1.18198430276417	1.09925646685243	1.20146593645479	NA	1.2445069689692	0.636465509515374	0.626039089718274	0.82260201888941	0.593315799828799	0.853098394716774	0.83318482043381	0.82260201888941	NA	0.904725235701373	0.630383390495557	0.608596459252162	p.Asp236=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D236E	236	D	E	missense	wt-like	1.00540272937462	0.231947262813404	8	0.0820057412065081	0.844674430084348	1.16613102866488	0.739154436092471	0.931597145832939	0.995923379152479	0.951417637300926	1.39700191753803	1.19923099541963	1.12633524897733	0.702561074683135	0.760089491203808	0.658785039678033	0.737674129276902	0.782504853130713	0.712942951919403	0.901962266627309	0.882409944826373	0.894223995545621	0.647029477515915	p.Asp236Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.146	-2.565	0.419	26.905	26.905	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.8	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
D236F	236	D	F	missense	possibly_low	0.558126739401568	0.209739702636079	7	0.0792741561759575	0.402752248391888	0.713501230411248	0.773591758277026	0.506298346784338	0.752556547866905	0.708407323091345	0.189165011859797	NA	0.554004705639937	0.422863482291627	0.585970546355999	0.675169508945847	0.541618540506718	0.663144991476088	0.606370404093701	0.450789492760361	NA	0.585970546355999	0.506551905199318	p.Asp236Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.146	-4.618	2.472	4.366	NA	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D236G	236	D	G	missense	wt-like	0.923365840780096	0.111154333469626	8	0.0392989914773218	0.846341232855799	1.00039044870439	0.898522177398913	0.9127300719871	0.939297857601273	1.10410058708482	0.742926494563654	0.814694581688726	0.975331357810643	0.999323598105639	0.74467059775513	0.734608468855327	0.728976725758502	0.754732726654932	0.779902294863094	0.657640354029483	0.69288244819421	0.812894297462838	0.796077878285083	p.Asp236Gly	1	0	NA	NA	NA	NA	NA	NA	NA	-0.286	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.146	-2.948	0.802	21.634	21.634	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.645	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
D236H	236	D	H	missense	possibly_wt-like	0.804146121613007	0.255213734781721	7	0.0964617247714897	0.615084615174272	0.993207628051742	0.921803856905588	0.594364875134674	NA	1.29569542000633	0.762766960871266	0.800138716564088	0.511083638786984	0.743169383022116	0.66742492147583	0.745685345284217	0.582215727955391	NA	0.863926504128037	0.665051518713007	0.685708259795192	0.562853543333286	0.66742492147583	p.Asp236His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.146	-3.336	1.19	13.617	13.617	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.645	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D236I	236	D	I	missense	possibly_low	0.548987743719656	0.214598815980108	6	0.0876095997594483	0.377276083491169	0.720699403948144	0.435319209569441	0.368662248902071	0.4079605585378	0.438861084117157	0.867473493451936	NA	NA	0.775649867739532	0.504182206647465	0.514227373295993	0.47817061573782	0.494137039998938	0.488160485565139	0.704163369430869	NA	NA	0.683738181814453	p.Asp236Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.146	-3.297	1.151	9.298	9.298	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.645	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D236K	236	D	K	missense	possibly_wt-like	0.788976492705384	0.417120108326362	2	0.294948457166838	0.210888139362727	1.36706484604804	NA	NA	NA	NA	0.494028035538546	NA	1.08392494987222	NA	0.718024726502173	NA	NA	NA	NA	0.564667364347147	NA	0.871382088657199	NA	p.Asp236Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.146	-2.709	0.563	10.519	10.519	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D236L	236	D	L	missense	low	0.611624056847408	0.109790395155556	8	0.038816766461822	0.535544592585934	0.687703521108881	0.63575805669304	0.652214934132813	0.599614163558264	0.793089918263611	0.622468861168065	0.414357837873484	0.654457525700496	0.52103115738949	0.60923755089362	0.609591470224687	0.608883631562553	0.588134022496562	0.64350808671987	0.612644871330585	0.49556740037075	0.640073771537601	0.555856429274052	p.Asp236Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.146	-2.804	0.658	27.302	27.302	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D236M	236	D	M	missense	possibly_low	0.654978070782411	0.100932323089143	8	0.0356849650486222	0.585036824497541	0.724919317067281	0.8422157336538	0.592766898303302	0.728590253029603	0.549946746612463	0.638051873427621	0.550411845270314	0.715414971814425	0.622426244147763	0.612623815231029	0.707819185060914	0.581479087529374	0.651390663160092	0.536877274058408	0.618465715877803	0.562624704979463	0.672905049261901	0.606781914584256	p.Asp236Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.146	-3.547	1.401	6.551	6.551	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D236N	236	D	N	missense	possibly_low	0.602299502511524	0.374874874197956	7	0.141689384270631	0.324593412349432	0.880005592673617	NA	0.728381253992169	0.903186873688923	0.810240463669197	0.0891612820773431	0.0394880334017285	0.732840929168937	0.912797681582374	0.651029484840022	NA	0.643995023172144	0.737022005677788	0.651029484840022	0.413434316783472	0.310804311447161	0.682290554757792	0.752620404834104	p.Asp236Asn	1	0	NA	NA	NA	NA	NA	NA	NA	-1.438	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.146	-2.639	0.493	13.911	13.911	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.095	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
D236P	236	D	P	missense	possibly_wt-like	0.769593674917068	0.406760031842226	5	0.181908616345839	0.413059338401709	1.12612801143243	NA	0.988395228744263	0.892701648593939	0.959103006021563	NA	0.0447173845159484	NA	0.963051106709626	0.731879501211819	NA	0.763857089612337	0.731879501211819	0.716313382216579	NA	0.313381715797695	NA	0.777860089960134	p.Asp236Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.146	-3.595	1.449	15.591	15.591	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.645	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
D236Q	236	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp236Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.146	-2.709	0.563	8.387	8.387	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.95	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D236R	236	D	R	missense	possibly_low	0.643559196767594	0.231993201515754	6	0.0947108279180451	0.457929385102255	0.829189008432933	0.388964929829341	0.641589808942952	0.917776458542863	0.813380652070216	0.346506361624164	NA	NA	0.753136969596029	0.628196123484583	0.492173095447005	0.603985627666198	0.744177503493845	0.652406619302968	0.509562438746224	NA	NA	0.672431122465214	p.Asp236Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.146	-3.274	1.128	21.769	21.769	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.645	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D236S	236	D	S	missense	wt-like	0.854998871996099	0.138386284327794	6	0.0564959640004679	0.74426881728331	0.965728926708887	1.02816952287325	0.698274581502986	0.914923749433493	0.982877246892692	0.767023607054908	NA	NA	0.738724524219268	0.696690574636512	0.796291631564491	0.630116353836651	0.74277838528683	0.726739612191629	0.666641537081394	NA	NA	0.665192499778613	p.Asp236Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.146	-2.789	0.643	10.423	10.423	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D236T	236	D	T	missense	possibly_low	0.671762279708572	0.12864838277039	8	0.0454840719228128	0.58261513686963	0.760909422547515	0.585520086980389	0.648263787484956	0.680460784289337	0.425733830601602	0.856773812804696	0.695618311033444	0.702726777572199	0.779000846901953	0.63098922653435	0.585689423880229	0.607062219453947	0.627785446705564	0.482403508304084	0.700166633965665	0.634193006363136	0.666071271675356	0.685421204587712	p.Asp236Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.146	-2.711	0.565	9.946	9.946	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.67	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D236V	236	D	V	missense	low	0.487043297714837	0.0908547578082913	8	0.0321220076746521	0.4240853195614	0.550001275868275	0.44602331701946	0.557331468236196	0.522014387503306	0.61536154773281	0.405855505873213	0.339987511263595	0.456840073142278	0.55293257094784	0.541856669262066	0.519320136276062	0.565143950631098	0.55007502125378	0.565565035907457	0.531731589160152	0.458912297439582	0.533638317270351	0.57187885224819	p.Asp236Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.146	-3.268	1.122	10.622	10.622	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.3	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
D236W	236	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp236Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.146	-5.8	3.654	0.914	NA	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D236X	236	D	X	nonsense	low	-0.00436788642288716	0.0469609239813347	3	0.0271129021020171	-0.0575081980592011	0.0487724252134267	NA	0.0244239147470067	0.0210307166355796	-0.0585582906512478	NA	NA	NA	NA	0.304366346287184	NA	0.319482537071682	0.304366346287184	0.270016452134452	NA	NA	NA	NA	p.Asp236Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D236Y	236	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp236Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21.1	52.9	32.3	0.804	115.1	0.3	29.6	106.8	60.427807486631	-0.5	0	0	41.61	0	0	0	0	4	38.2345626084568	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.146	-3.559	1.413	10.554	10.554	42.43	0.002880325	0	0.082324491	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K237A	237	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.239	-2.726	0.487	11.5	11.5	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K237C	237	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.239	-3.609	1.37	16.67	16.67	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K237D	237	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.239	-2.629	0.39	19.787	19.787	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.93	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K237E	237	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.239	-2.819	0.58	13.047	13.047	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.185	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
K237F	237	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.239	-3.761	1.522	13.677	13.677	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K237G	237	K	G	missense	wt-like	1.05352449860314	0.142285941053605	8	0.0503056768932568	0.954927183674444	1.15212181353183	1.16830622843488	1.10188301016845	1.01494737875077	1.11858796658335	0.731726571177427	1.14146048657034	1.0115439840567	1.13974036308318	0.824285612798835	0.862965385501056	0.816173046899575	0.79183522057715	0.786255757470217	0.653456758978276	0.85393643872811	0.832398178698095	0.866601925660449	p.Lys237Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.239	-2.845	0.606	27.96	27.96	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.185	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K237H	237	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.239	-3.535	1.296	14.319	14.319	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K237I	237	K	I	missense	possibly_low	0.282665005932949	0.642735073390171	2	0.454482328900623	-0.60810399032216	1.17343400218806	NA	NA	NA	NA	-0.171817322967675	NA	0.737147334833572	NA	0.50027944599769	NA	NA	NA	NA	0.31594893559952	NA	0.684609956395861	NA	p.Lys237Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.239	-3.04	0.801	9.365	9.365	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K237L	237	K	L	missense	wt-like	1.0568581280944	0.345642595815245	5	0.154576068032474	0.753894601878937	1.35982165430986	NA	1.00755125862951	0.813532926757132	0.952214506610192	1.65945922740996	NA	0.85153272106521	NA	0.746217169663184	NA	0.7726876970019	0.693051006647059	0.713292420183122	1	NA	0.746217169663184	NA	p.Lys237Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.239	-3.111	0.872	11.834	11.834	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K237M	237	K	M	missense	wt-like	1.26831520746157	0.272829313254565	4	0.136414656627282	1.0009473935087	1.53568302141444	NA	1.16791238036245	1.02816088386744	1.21772833820642	1.65945922740996	NA	NA	NA	0.838172697777569	NA	0.846611475313832	0.798315816697695	0.829733920241305	1	NA	NA	NA	p.Lys237Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.239	-3.936	1.697	4.662	4.662	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.735	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K237N	237	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.239	-2.78	0.541	15.011	15.011	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	low	1.93	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
K237P	237	K	P	missense	possibly_wt-like	0.952690362777449	0.293004295335101	3	0.169166108785437	0.621130882153207	1.28424984340169	0.863104934546399	1.28002927731215	NA	0.714936876473796	NA	NA	NA	NA	0.717757776343353	0.717757776343353	0.898295477929713	NA	0.609233949792966	NA	NA	NA	NA	p.Lys237Pro	0	0	NA	NA	NA	NA	NA	NA	NA	108.748	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.239	-3.168	0.929	35.969	35.969	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.185	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K237Q	237	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.239	-2.98	0.741	8.865	8.865	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K237R	237	K	R	missense	possibly_wt-like	0.824252705582951	0.263138679247032	7	0.0994570722299487	0.629320426004453	1.01918498516145	0.962751743050662	0.934921294615486	0.875328001348826	0.757119427418309	1.04742805884068	0.262192951783654	NA	0.930027462023045	0.739206505921698	0.765167388008979	0.739206505921698	0.723358553140717	0.627733172521706	0.771383206856576	0.42056948364262	NA	0.761274028582375	p.Lys237Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.239	-2.811	0.572	17.159	17.159	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K237S	237	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.239	-2.6	0.361	10.587	10.587	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.585	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K237T	237	K	T	missense	possibly_wt-like	0.719426514053292	0.242274339184487	3	0.139877154945902	0.445272328099395	0.993580700007189	NA	0.993445793387115	0.533611840401052	0.631221908371708	NA	NA	NA	NA	0.572520621509737	NA	0.766185314913916	0.555763020584292	0.572520621509737	NA	NA	NA	NA	p.Lys237Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.239	-2.849	0.61	11.106	11.106	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.185	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
K237V	237	K	V	missense	possibly_low	0.671994121469305	0.304666554363263	7	0.115153133663448	0.44629812678202	0.897690116156589	NA	0.871722972463667	0.796868778963625	0.887956620878142	0.113248520885084	0.975514513079817	0.599231521536044	0.459415922478754	0.684878034329023	NA	0.7100731430096	0.684878034329023	0.685112025360657	0.422431811641093	0.772146200381902	0.610329410579012	0.524910297260654	p.Lys237Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.239	-3.046	0.807	13.829	13.829	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K237W	237	K	W	missense	possibly_low	0.543886391005624	0.457527391241768	6	0.186784775314843	0.177794958528126	0.909977823483122	0.736207501304452	NA	0.671373224808554	1.26024261487372	-0.0293483996362083	NA	0.163257199946735	0.461586204736493	0.574664374044635	0.657382957303284	NA	0.6233284307816	0.848378621797032	0.369166467724192	NA	0.375516521502102	0.526000317307671	p.Lys237Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.239	-5.809	3.57	0.696	NA	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K237X	237	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K237Y	237	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys237Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	21	56.7	32.8	0.13	125.2	85.5	77.4	-23	55.2173913043478	-0.8	0	0	41.17	0	0	0	0	5	34.9586658478266	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.239	-3.752	1.513	8.033	8.033	72.7	0.0026992	0	0.077147639	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F238A	238	F	A	missense	possibly_wt-like	0.792105001805983	0.196684841241907	8	0.0695385924993761	0.655811864971599	0.928398138640368	0.843003592217201	1.0092141420633	0.883202002534845	0.647939316160282	0.64005081395719	0.437297280920978	0.924528341406596	0.951604525187472	0.717707203038195	0.708194029665563	0.773454258279284	0.727220376410828	0.579852066460395	0.619212395780761	0.506873625372292	0.785532128488829	0.772111066631733	p.Phe238Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.669	-2.798	0.129	12.003	12.003	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238C	238	F	C	missense	wt-like	1.20163483893472	0.104422697963575	4	0.0522113489817876	1.09930247534617	1.30396720252328	NA	1.2747944291468	1.24162798637043	1.24344228750365	1.04667465271801	NA	NA	NA	0.868446556680894	NA	0.895882301025673	0.90301128274776	0.841010812336115	0.771101781170198	NA	NA	NA	p.Phe238Cys	1	0	NA	NA	NA	NA	NA	NA	NA	5.07	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.669	-3.25	0.581	42.094	42.094	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	D	0.5
F238D	238	F	D	missense	possibly_low	0.600639716019175	0.215653108581635	5	0.0964430020695356	0.411614905401963	0.789664526636387	0.665510808955879	NA	NA	NA	0.322851100024353	0.427990319653511	0.809415992027256	0.777430359434876	0.623747131122792	0.623747131122792	NA	NA	NA	0.500726303716436	0.502286478336823	0.72353337767328	0.684632430308883	p.Phe238Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.669	-3.379	0.71	16.538	16.538	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238E	238	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.669	-2.896	0.227	11.057	11.057	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.1	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238G	238	F	G	missense	wt-like	0.79281868588737	0.101563492043087	8	0.0359081169723264	0.722440069868959	0.863197301905781	0.89703645539461	0.839451166824042	0.788120326816499	0.937066279845756	0.618178776422908	0.709480056923888	0.790221473570646	0.762994951300613	0.687891859080918	0.733901597212127	0.695196383729989	0.680587334431847	0.706649141989032	0.611042362394571	0.641025082348027	0.71319533685288	0.677382274621944	p.Phe238Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.669	-3.144	0.475	23.279	23.279	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238H	238	F	H	missense	wt-like	1.05998743093902	0.138901497279304	7	0.0524998312193648	0.957089652554631	1.1628852093234	0.810234850003843	1.18362735047243	1.1232594313803	1.20402940001079	1.11389601173007	0.966803759674355	1.01806121330133	NA	0.823726229782721	0.692603431567884	0.853855812058514	0.844957133489841	0.823726229782721	0.796211501585265	0.767852907919168	0.835908315309189	NA	p.Phe238His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.669	-3.72	1.051	31.801	31.801	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.26	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
F238I	238	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.669	-2.614	-0.055	13.363	8.692	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	D	0.357142857142857
F238K	238	F	K	missense	possibly_low	0.69992466937705	0.430886043339018	7	0.162859616297663	0.380725686897618	1.01912365185648	0.43583755054941	1.11508264149241	0.837313769982021	0.791100012435869	-0.131041440124597	1.08735442811997	NA	0.763825723184278	0.677799528186296	0.514473987763025	0.822257854795946	0.704714379763103	0.642635410452258	0.331180270296032	0.827269040155268	NA	0.677799528186296	p.Phe238Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.669	-3.472	0.803	7.7	7.7	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.3	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238L	238	F	L	missense	possibly_wt-like	0.848841415882121	0.249451464694099	8	0.0881944111310571	0.675983546427531	1.02169928533671	0.885130479979671	0.992887291179312	0.902285348786915	1.03035070262079	1.02838802040211	0.271552680173465	0.917724850655742	0.762411953258961	0.742069509968666	0.728237013675579	0.765927854795465	0.736579850569743	0.747559169367589	0.764271032260422	0.425182638151621	0.781867813321843	0.677089464988309	p.Phe238Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.669	-2.556	-0.113	33.545	33.545	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	neutral	neutral	neutral	-0.425	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
F238M	238	F	M	missense	wt-like	0.996982608795519	0.182450856868886	5	0.0815945037023829	0.837060320202428	1.15690489738861	0.984072858244064	1.0716843969466	1.10479756507237	NA	NA	1.13734450761516	NA	0.687013716099398	0.802251994433645	0.7753114739739	0.802251994433645	0.835902465699821	NA	NA	0.851907785108553	NA	0.639220846876286	p.Phe238Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.669	-3.551	0.882	4.944	4.944	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
F238N	238	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.669	-3.034	0.365	14.304	14.304	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F238P	238	F	P	missense	low	0.176966081089819	0.294619484605987	7	0.111355698237352	-0.041287076928701	0.395219239108339	NA	0.27826413289559	0.11996340763108	0.365887796168303	-0.197278890760416	-0.0610442903688947	0.0478485819334467	0.685121830129625	0.352888128191334	NA	0.436498605619257	0.352888128191334	0.456157937668259	0.306438076878406	0.261254674600041	0.313358202357789	0.638270650823967	p.Phe238Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.669	-3.505	0.836	18.905	18.905	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.3	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
F238Q	238	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.669	-3.247	0.578	8.334	8.334	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
F238R	238	F	R	missense	wt-like	0.987138009626875	0.238076698064433	8	0.0841728238219315	0.822162306458855	1.1521137127949	0.48843112839517	1.12137384037044	1.02604802228676	0.809677369473066	1.23782691910912	1.14856976323598	1.07727006769322	0.987906966451244	0.811218775066747	0.539496777144851	0.825157991600619	0.797279558532876	0.650782539012465	0.842504383502674	0.857440407042142	0.867797813085142	0.790343897219571	p.Phe238Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.669	-2.998	0.329	15.11	15.11	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
F238S	238	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.669	-2.64	-0.029	10.969	10.969	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	N	T	T	D	D	0.285714285714286
F238T	238	F	T	missense	wt-like	1.07016851621342	0.205581885031577	7	0.0777026488362035	0.9178741229911	1.22246290943574	NA	1.13758282278212	1.14626143205743	1.15217265067266	1.1848535207157	1.25398944152608	0.969844950822158	0.646474794917809	0.822716815345121	NA	0.832630059702378	0.856238521360561	0.800984372438519	0.822716815345121	0.909398887458178	0.809939354908145	0.61886025248135	p.Phe238Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.669	-2.867	0.198	9.946	9.946	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
F238V	238	F	V	missense	wt-like	1.01170111563752	0.118356358168288	8	0.0418452917286702	0.929685850926756	1.09371638034829	0.870197553955981	1.03549548338748	1.00103580346909	1.23610554260514	0.934039216266417	0.987582970905564	0.913661660156188	1.11549069435431	0.782345829995016	0.72113227811564	0.785569514326348	0.785012254225295	0.837793271553433	0.729028184924981	0.77809441365443	0.779679405764737	0.854422576659317	p.Phe238Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.669	-2.704	0.035	21.912	21.912	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
F238W	238	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.669	-4.36	1.691	13.43	13.43	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.65	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
F238X	238	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe238Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F238Y	238	F	Y	missense	wt-like	1.08286640850517	0.208892941666937	5	0.0934197635174339	0.89976703656675	1.26596578044359	NA	1.05964474038881	1.10213197606097	0.804243398635607	1.39160502746082	NA	NA	1.05670689997965	0.824898530153575	NA	0.796701915382615	0.834595121005603	0.648399462726826	0.899946324031963	NA	NA	0.824898530153575	p.Phe238Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.6	56.5	34	0.913	54.4	-177.9	-112.9	140.1	24.1228070175439	-4.6	0	1	31.5	0	0	0	0	8	34.1491194302284	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.669	-2.867	0.198	28.826	28.826	86.35	0.002544407	0	0.07272339	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.295	Neutral	TOLERATED	neutral	DAMAGING	null	N	N	T	T	D	B	0.142857142857143
M239A	239	M	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.931	-2.752	-0.179	11.788	11.788	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.585	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
M239C	239	M	C	missense	low	0.578069604801955	0.045807984799547	5	0.0204859535848128	0.537917873586763	0.618221336017147	0.607531223942344	NA	NA	NA	0.517311922416552	0.581101053358094	0.550817319528732	0.633586504764053	0.58425384125592	0.596161806000129	NA	NA	NA	0.573364776870119	0.577750577523151	0.58425384125592	0.612387133794017	p.Met239Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.931	-3.734	0.803	12.352	12.352	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
M239D	239	M	D	missense	low	0.406807962032031	0.150884331279015	5	0.0674775242958949	0.274554444646151	0.539061479417911	0.420780849327934	NA	0.649646728270733	0.29524582541299	0.267461406816238	NA	0.40090500033226	NA	0.503512056624156	0.507310362870362	NA	0.612672617056717	0.425177792519648	0.480036158042909	NA	0.503512056624156	NA	p.Met239Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.931	-3.367	0.436	15.948	15.948	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239E	239	M	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.931	-3.203	0.272	11.573	11.573	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M239F	239	M	F	missense	possibly_wt-like	0.822871691292049	0.138016616619355	4	0.0690083083096773	0.687617892371046	0.958125490213053	NA	NA	NA	NA	0.943832624676226	0.93157959425407	0.754528759561537	0.661545786676365	0.713328935170354	NA	NA	NA	NA	0.732686393427381	0.750491878756048	0.693971476913326	0.62642962880863	p.Met239Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.931	-3.03	0.099	19.608	19.608	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.135	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
M239G	239	M	G	missense	low	0.256497873877481	0.124908886760318	8	0.0441619604293418	0.169942021949288	0.343053725805674	0.226813262108942	0.197183207268018	0.342045779890963	0.32443117075374	0.0148112348407324	0.225455268097393	0.437508720783349	0.283734347276708	0.425849853461242	0.415025139451717	0.399121663461166	0.461808974507343	0.43797707069948	0.385661761655225	0.40246248266041	0.523226578614238	0.436674567470767	p.Met239Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.931	-2.852	-0.079	15.814	15.814	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M239H	239	M	H	missense	low	0.41584177827546	0.269961138373302	5	0.120730291337186	0.179214755411548	0.652468801139373	NA	0.360319856581121	0.547941630694853	0.664738612180895	NA	-0.0262398942942949	NA	0.532448686214728	0.561590860941877	NA	0.474324913276646	0.562791101518628	0.58721942362142	NA	0.27840881091658	NA	0.561590860941877	p.Met239His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.931	-3.914	0.983	9.663	9.663	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239I	239	M	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.931	-2.282	-0.649	17.181	17.181	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	neutral	neutral	low	1.13	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M239K	239	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.931	-3.21	0.279	9.832	9.832	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
M239L	239	M	L	missense	wt-like	0.981926041900156	0.0728949942614416	5	0.0325996324776081	0.918031936334802	1.04582014746551	0.949720476035822	0.879599852586666	1.04635430919987	NA	1.05659231680866	NA	0.977363254869762	NA	0.77480640386969	0.758967417152329	0.713704252181883	0.807238826950289	NA	0.77480640386969	NA	0.813988663793909	NA	p.Met239Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.931	-2.412	-0.519	30.656	30.656	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	0.96	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M239N	239	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.931	-3.293	0.362	9.824	9.824	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239P	239	M	P	missense	low	0.239740228267693	0.133198026202646	5	0.059567968211583	0.122989155940763	0.356491300594622	0.200072166354961	0.168625220133184	0.360656553686564	0.39225510018482	NA	NA	NA	0.0770921009789361	0.402302354003397	0.402302354003397	0.385956912010336	0.470936674341352	0.467721359482165	NA	NA	NA	0.332888900780699	p.Met239Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.931	-3.314	0.383	16.327	16.327	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239Q	239	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.931	-3.681	0.75	6.476	6.476	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239R	239	M	R	missense	low	0.289900502421181	0.272821193191008	8	0.0964568578783833	0.100848534917651	0.478952469924711	0.042461942775827	0.173310659750591	0.257385909471908	0.219246526985918	-0.0592144943330044	0.76476911534262	0.591920211455818	0.329324147919771	0.406067757831606	0.327315110492236	0.388116820820079	0.420287332599374	0.391848183063839	0.358010351591642	0.668275549297523	0.606391587276445	0.459571956261195	p.Met239Arg	1	0	NA	NA	NA	NA	NA	NA	NA	6.124	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.931	-3.828	0.897	7.854	7.854	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	2	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
M239S	239	M	S	missense	low	0.307051745878972	0.104562134491805	5	0.0467616081192305	0.215400678106104	0.398702813651839	NA	0.210672428676341	0.279903077837295	0.214906631427573	0.383593153662849	NA	NA	0.4461834377908	0.431330933268985	NA	0.405339967512756	0.431330933268985	0.389944915178051	0.523415758477769	NA	NA	0.518264307537302	p.Met239Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.931	-2.89	-0.041	7.749	7.749	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M239T	239	M	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.931	-2.82	-0.111	14.401	14.401	87.34	0.00246937	0	0.070578718	4.061e-06	1	246218	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.785	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.5
M239V	239	M	V	missense	low	0.607130207112168	0.101182745278582	8	0.0357735026627783	0.537015430292275	0.677244983932061	0.72049367460399	0.428750859824693	0.65139863031513	0.678645851487773	0.560593459196852	0.538019568208287	0.713307121000079	0.565832492260538	0.591425266474245	0.649906687537775	0.505870454108328	0.613531841728161	0.59331846485338	0.589532068095111	0.556516890048881	0.6717697747401	0.578357812662502	p.Met239Val	1	0	NA	NA	NA	NA	NA	NA	NA	1.427	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.931	-2.313	-0.618	23.516	23.516	87.34	0.00246937	0	0.070578718	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 17, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.98	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M239W	239	M	W	missense	wt-like	0.895968966772695	0.191587073366135	6	0.0782150951766993	0.742670197178992	1.0492677363664	NA	0.94844705902139	0.864961422978693	0.661689810492191	0.753061583836315	1.21741742015781	NA	0.930236504149766	0.731857947466635	NA	0.745441655680171	0.718274239253099	0.585882366942005	0.661426193259133	0.891373536908267	NA	0.761379019584345	p.Met239Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.931	-3.583	0.652	19.467	19.467	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M239X	239	M	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met239Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M239Y	239	M	Y	missense	possibly_wt-like	0.801985273813016	0.241105477159333	8	0.0852436589402914	0.634910772379629	0.969059775246403	0.79411742702207	0.978337593502027	0.795144044675174	1.10175808166619	1.02015955825665	0.351868322305176	0.618998783512852	0.75549837956399	0.684483637159504	0.684935140168629	0.759220689031231	0.684032134150379	0.77887498550147	0.761197390385947	0.464768024736831	0.620975927275211	0.673617136033322	p.Met239Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	56.6	31.8	0.988	11.1	-156	-130.5	139.2	1.97044334975369	-5	0	1	22.72	0	0	0	0	7	32.7039208331356	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.931	-3.487	0.556	11.814	11.814	87.34	0.00246937	0	0.070578718	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y240A	240	Y	A	missense	possibly_low	0.67856834133906	0.187504532989074	7	0.0708700519980566	0.539665591840388	0.817471090837732	NA	0.525273632123953	0.769175689968319	0.363093601796756	0.723537792851917	0.628716759986368	0.839713196968101	0.900467715678006	0.650397940511699	NA	0.550365827702597	0.671295890641619	0.454932539420187	0.650397940511699	0.601219058934494	0.739851252077398	0.746427703416183	p.Tyr240Ala	0	0	no	NA	NA	NA	NA	NA	NA	4.131	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.692	-2.98	0.288	8.913	8.913	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y240C	240	Y	C	missense	wt-like	0.983113358601408	0.106113442173649	8	0.0375167672680169	0.909581845939724	1.05664487126309	0.897879826643906	0.953504013727635	0.933833219730372	1.15755302823299	0.989802914711152	1.12058272528362	0.846937845781733	0.964813294699862	0.750955308628747	0.734302853449223	0.747772826693432	0.752052581555381	0.803343945309875	0.749858035702113	0.843646360361888	0.743742400194358	0.778745145454238	p.Tyr240Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.692	-3.374	0.682	19.548	19.548	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.435	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	D	0.428571428571429
Y240D	240	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.692	-3.341	0.649	11.419	11.419	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	N	D	T	T	D	D	0.5
Y240E	240	Y	E	missense	wt-like	0.945525990508659	0.206834413304762	3	0.119415904199183	0.711475119096976	1.17957686192034	NA	1.0215491312327	1.10359051783058	NA	0.711438322462691	NA	NA	NA	0.77914048069395	NA	0.77914048069395	0.83531046640793	NA	0.645878330627148	NA	NA	NA	p.Tyr240Glu	0	0	no	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.692	-2.847	0.155	14.3	14.3	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y240F	240	Y	F	missense	wt-like	0.851108150348108	0.165273319751703	8	0.0584329425728209	0.736581687394682	0.965634613301534	0.559312101521762	0.983962879330701	0.735021426824446	0.918566137073222	0.769461203394241	1.09360484963994	0.91818674566562	0.830749859334929	0.70497396069783	0.573220279792401	0.76181385112717	0.654544848183476	0.698535875863596	0.667552071522604	0.83034970222335	0.782116586922371	0.711412045532064	p.Tyr240Phe	1	0	no	NA	NA	NA	NA	NA	NA	0.192	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.692	-2.81	0.118	34.624	34.624	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.025	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	T	B	0.142857142857143
Y240G	240	Y	G	missense	low	0.411088260401725	0.191672959405936	8	0.0677666246830154	0.278268116669172	0.543908404134278	0.354357816616796	0.672473658428297	0.527999723709465	0.595021599229204	0.118933486591056	0.262675499417691	0.258955164918928	0.498289134302364	0.510071067981018	0.47570784359496	0.618222562517376	0.553010544133992	0.556644920143138	0.424555361380999	0.420807318193053	0.42705881314897	0.544434292367076	p.Tyr240Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.692	-3.371	0.679	15.435	15.435	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y240H	240	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.692	-3.667	0.975	32.065	32.065	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	B	0.357142857142857
Y240I	240	Y	I	missense	possibly_wt-like	0.961717114831875	0.423040595929494	6	0.17270560008503	0.623220358736839	1.30021387092691	NA	1.35926982162026	1.20604293692132	1.33075789712505	0.32828798109098	0.58803895239547	NA	0.95790509983818	0.827289362757393	NA	0.934824035272335	0.885558507623136	0.879303207506968	0.502757184459095	0.581170078484536	NA	0.775275518007818	p.Tyr240Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.692	-2.562	-0.13	23.986	23.986	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y240K	240	Y	K	missense	low	0.507256546080214	0.165441304872194	4	0.0827206524360969	0.345127046527809	0.66938604563262	0.558739074275469	NA	NA	NA	0.370823994833425	NA	0.380557193241679	0.718905921970284	0.545796820756016	0.572947646883948	NA	NA	NA	0.518645994628084	NA	0.492552862165406	0.655238645307286	p.Tyr240Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.692	-3.047	0.355	15.126	15.126	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.575	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y240L	240	Y	L	missense	wt-like	0.985003940112053	0.155032370890433	8	0.0548122203800264	0.877573962254529	1.09243391796958	1.08492789446721	1.02187420319588	0.746777493705085	0.993751733563057	0.970056704777947	1.2660602639239	0.952229278716112	0.844353948547236	0.760886206369041	0.823295932017606	0.779290333398157	0.660310640132458	0.731508635080748	0.742482079339925	0.915348266163705	0.800451670300544	0.718244672905732	p.Tyr240Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.692	-2.607	-0.085	32.893	32.893	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.28	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y240M	240	Y	M	missense	wt-like	1.03457451437552	0.0643026045780312	2	0.045468807745083	0.945457288775181	1.12369173997586	1.0800433221206	NA	NA	NA	NA	NA	NA	0.989105706630436	0.805958964667898	0.820971967190419	NA	NA	NA	NA	NA	NA	0.790945962145377	p.Tyr240Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.692	-4.107	1.415	7.677	7.677	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y240N	240	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.692	-3.128	0.436	12.653	12.653	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.78	Neutral	TOLERATED	effect	DAMAGING	pathogenic	N	D	T	T	D	D	0.428571428571429
Y240P	240	Y	P	missense	low	0.251476313549414	0.191973744358409	5	0.0858532684561139	0.083206999420382	0.419745627678446	NA	0.414866365342043	0.223755762923712	0.366325070131806	NA	-0.0679232290967766	NA	0.320357598446284	0.455068524210451	NA	0.499469935821745	0.403793344416132	0.456349704838883	NA	0.257864233564998	NA	0.455068524210451	p.Tyr240Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.692	-3.631	0.939	17.064	17.064	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y240Q	240	Y	Q	missense	possibly_low	0.698096004353802	0.167861802474347	7	0.0634457977105955	0.573744525870621	0.822447482836983	0.619515263417467	0.86470193667409	0.663802830147162	0.876013177710876	0.746714052931905	0.383801655628702	0.73212311396641	NA	0.659055150354346	0.601863530583479	0.70683656367154	0.619615512079074	0.679874209952339	0.659055150354346	0.480507092632138	0.681903944232397	NA	p.Tyr240Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.692	-3.485	0.793	9.661	9.661	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y240R	240	Y	R	missense	low	0.391027065488044	0.113956507319445	6	0.0465225493003963	0.299844544390278	0.48220958658581	0.564970995186282	0.398324235879622	0.335956765791003	0.444698439409035	NA	0.22193612829529	NA	0.380275828367031	0.487941402744964	0.575912648520703	0.491844292536312	0.458822602548827	0.490720466724963	NA	0.400727994759719	NA	0.485162338764965	p.Tyr240Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.692	-2.944	0.252	17.501	17.501	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.435	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y240S	240	Y	S	missense	wt-like	0.889519969861839	0.0809512802273501	8	0.0286205995972459	0.833424625435295	0.945615314288382	0.770065062285612	0.953162099504626	0.757207998681609	0.930379741144269	0.943319812616267	0.961426813270496	0.906567966369729	0.894030265022103	0.737844672528485	0.673491589803976	0.74761520999089	0.665426306981589	0.703716750136158	0.732494838724526	0.765202757881201	0.775858789160178	0.743194506332443	p.Tyr240Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.692	-2.883	0.191	15.989	15.989	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.085	Neutral	TOLERATED	effect	DAMAGING	pathogenic	N	D	T	T	D	B	0.357142857142857
Y240T	240	Y	T	missense	possibly_wt-like	0.800651924944312	0.285726162337733	8	0.10101945347571	0.602657434394002	0.998646415494623	1.0199334095026	0.654176362303168	0.873208020511877	0.780972366714001	0.701307342323776	0.229431585632565	0.996691337698782	1.14949497486773	0.682206414816762	0.792373082216072	0.609787816939116	0.722318803319133	0.638193915812138	0.642094026314391	0.404422300980198	0.824398641502815	0.871501160475696	p.Tyr240Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.692	-2.592	-0.1	10.801	10.801	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.435	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y240V	240	Y	V	missense	possibly_wt-like	0.869644090700617	0.235638851370603	8	0.0833109148575811	0.706357698060675	1.03293048334056	0.522211230737173	0.991815521249815	1.02950222102038	0.984950280558812	0.582667281992641	1.07958559953133	0.674170970757726	1.09224961975707	0.74654126559813	0.555568556643849	0.765433786895381	0.798973678807174	0.727648744300879	0.59777747590953	0.823439996710764	0.650691302796489	0.842749792101059	p.Tyr240Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.692	-2.553	-0.139	21.244	21.244	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y240W	240	Y	W	missense	wt-like	1.36485138895376	0.416638400726179	2	0.294607838456199	0.787430636016415	1.9422721418911	NA	NA	NA	NA	1.65945922740996	NA	1.07024355049756	NA	0.932006688674271	NA	NA	NA	NA	1	NA	0.864013377348542	NA	p.Tyr240Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.692	-3.762	1.07	15.278	15.278	24.81	0.002605729	0	0.074476071	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y240X	240	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr240Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.2	56.2	33.2	0.935	9.4	-165.9	-121.6	146.8	9.01960784313725	-5.4	0	1	20.27	1	5	0	0	8	32.8034519198818	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	4	1	1	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F241A	241	F	A	missense	low	0.234679811841995	0.335772537153463	5	0.150162043610543	-0.0596323854796027	0.528992009163593	0.114133872284567	0.61518482533826	0.504546564000963	NA	-0.228313427167586	NA	NA	0.16784722475377	0.378470485356285	0.361414931613854	0.591813374608664	0.541507884205427	NA	0.294845503567662	NA	NA	0.378470485356285	p.Phe241Ala	0	0	yes	NA	NA	NA	NA	NA	NA	12.284	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.187	-2.938	0.751	14.735	14.735	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.495	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F241C	241	F	C	missense	low	0.274066065493938	0.14808471421028	7	0.0559707609672106	0.164365389810905	0.383766741176971	0.0305546803598728	0.210674508844807	0.335573910866623	0.438873794281269	0.218344335200129	NA	0.453841429104752	0.230599799800113	0.458634830408448	0.321649914630826	0.405340926435411	0.458634830408448	0.4881660596272	0.461689073812345	NA	0.532023267404116	0.409987844242899	p.Phe241Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.187	-3.473	1.286	26.383	26.383	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
F241D	241	F	D	missense	low	0.291432941830237	0.194926713392779	6	0.0795784975083415	0.135461952770078	0.447403930890397	0.162575664036583	0.159151224161499	0.249226776521171	0.481205134060418	0.584476925638125	NA	NA	0.111961926563627	0.400374032207059	0.384462398660949	0.381589559310564	0.416285665753168	0.506730533928684	0.598453446265632	NA	NA	0.350402202927341	p.Phe241Asp	0	0	NA	NA	NA	NA	NA	NA	NA	17.113	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.187	-3.155	0.968	15.062	15.062	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241E	241	F	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.187	-3.001	0.814	9.14	9.14	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241G	241	F	G	missense	low	0.16415837475136	0.0977872186971611	8	0.0345730027270673	0.0963965345689026	0.231920214933817	0.115245140019762	0.212990622818211	0.220513331938894	0.351769388207624	0.0392628714719962	0.0894990760985284	0.113444778548792	0.170541788907068	0.387309598925441	0.361943646708426	0.406408615997973	0.402203086155677	0.449966288097721	0.394795372884234	0.335453388590014	0.348687880453409	0.379823824966648	p.Phe241Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.187	-3.183	0.996	27.96	27.96	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.495	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F241H	241	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.187	-3.606	1.419	10.454	10.454	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241I	241	F	I	missense	low	0.415524601933066	0.205789525860589	8	0.0727575846165934	0.272922356482417	0.558126847383714	0.367974891264833	0.549036211925488	0.575249054310351	0.754017136469321	0.219566779153696	0.18270499645678	0.463503301433803	0.212144444450255	0.509706807985763	0.482186527968055	0.561319977077367	0.576184094670867	0.626372658044756	0.462145702871148	0.381392041279374	0.537227088003472	0.400718677877823	p.Phe241Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.187	-2.151	-0.036	12.263	12.263	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.525	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
F241K	241	F	K	missense	low	-0.0312807999928994	0.122241792673462	2	0.0864380005438047	-0.20069616795441	0.138134567968611	NA	NA	NA	NA	-0.117718800536704	NA	0.0551572005509053	NA	0.326725678101079	NA	NA	NA	NA	0.336156780145865	NA	0.317294576056292	NA	p.Phe241Lys	0	0	NA	NA	NA	NA	NA	NA	NA	14.645	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.187	-3.155	0.968	10.794	10.794	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241L	241	F	L	missense	low	0.212891367489362	0.10517115149755	7	0.0397509588515449	0.134980919789401	0.290801815189324	0.259836625309543	0.207510598264201	0.364765211100887	0.059557715847088	0.145742427678474	NA	0.146784772588955	0.306042221636387	0.430736880236335	0.430736880236335	0.403882416904971	0.472951775487097	0.321816408825462	0.4345695149956	NA	0.366644580962372	0.447878654022949	p.Phe241Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.187	-2.405	0.218	17.797	17.797	42.43	0.002769842	0	0.0791667	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Dec 13, 2014)	criteria provided, single submitter	0	0	1	0	0	1	1	0	0	1	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	neutral	neutral	low	1.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.357142857142857
F241M	241	F	M	missense	low	0.386239378187163	0.117031670309184	6	0.0477779793338547	0.292596259438709	0.479882496935617	0.418331953829459	0.348189251648671	NA	NA	0.322142715592814	0.447201353210266	0.561282175953356	0.220288818888413	0.503303465614903	0.506145235895047	0.468732908555517	NA	NA	0.500461695334758	0.511755072123305	0.589890143783746	0.404809174114589	p.Phe241Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.187	-3.576	1.389	8.28	8.28	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F241N	241	F	N	missense	low	0.138088002263021	0.111072235730334	2	0.0785399310864699	-0.0158474340147175	0.29202343854076	0.0595480711765513	NA	NA	NA	NA	NA	NA	0.216627933349491	0.369207395324706	0.335444289183521	NA	NA	NA	NA	NA	NA	0.402970501465892	p.Phe241Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.187	-2.855	0.668	11.553	11.553	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.495	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241P	241	F	P	missense	low	0.0356503599452722	0.193054062070909	7	0.0729675768329217	-0.107363462686414	0.178664182576958	NA	0.0797022510956794	0.214212265669081	0.213852123966878	-0.34816440903113	0.0576288561321589	-0.0526938760852109	0.0850153078694483	0.336868316046396	NA	0.344964919818399	0.399112712688313	0.389482459305949	0.250076628164166	0.319745427544823	0.259206698764203	0.336868316046396	p.Phe241Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.187	-3.586	1.399	14.363	14.363	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241Q	241	F	Q	missense	possibly_low	0.422038120181078	0.434584932728633	5	0.194352290315679	0.0411146308494744	0.802961609512682	0.183685996712881	-0.0219617910708891	0.350750760887413	0.472943301274988	NA	NA	NA	1.124772333101	0.46607835387163	0.394506199253646	0.298099507340604	0.46607835387163	0.503107294427443	NA	NA	NA	0.859084261685298	p.Phe241Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.187	-3.627	1.44	7.803	7.803	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241R	241	F	R	missense	low	0.244542442113163	0.14890516595363	8	0.0526459262997602	0.141358322632883	0.347726561593443	0.446402462533256	0.186853375099412	0.174129982869102	0.22203030435579	0.421434107198318	0.268137401700124	-0.0264738019527922	0.263825705102096	0.408929562670691	0.519500524808757	0.394359784677959	0.379454258393064	0.393069012919772	0.537550786056498	0.423499340663423	0.273328657452962	0.426675490621744	p.Phe241Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.187	-4.373	2.186	4.176	NA	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F241S	241	F	S	missense	low	0.167143979691373	0.173543999913619	8	0.061357069586579	0.0468863331047606	0.287401626277986	0.290830004824528	0.261518861902453	0.305266429325155	0.333022322602262	-0.184582458685868	0.0565207612446964	0.103430872930694	0.171145043387065	0.404453062932014	0.445482802449668	0.428779317506947	0.443770451459269	0.441744733583389	0.311180674534065	0.319199277836882	0.343294457050495	0.380126808357082	p.Phe241Ser	1	0	NA	0.122151466914218	-2.18469081112508	0.0872167730725533	0.157086160755884	NA	NA	13.785	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.187	-3.339	1.152	9.332	9.332	42.43	0.002769842	0	0.0791667	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Apr 1, 2005)	no assertion criteria provided	1	0	0	0	0	4	0	0	0	0	0	1	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	null	D	A	D	D	D	D	0.642857142857143
F241T	241	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.187	-3.352	1.165	7.078	7.078	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.84	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F241V	241	F	V	missense	low	0.399506194254887	0.192597518470005	6	0.0786276076629617	0.245398915044937	0.553613473464838	0.099984738241204	0.348635879642101	0.353790117147214	0.391781671411755	0.532581224119029	NA	NA	0.67026353496802	0.46825390508855	0.354683105873825	0.468938796543937	0.467569013633162	0.467513736564086	0.579068438657345	NA	NA	0.630808100949229	p.Phe241Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.187	-2.551	0.364	19.574	19.574	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
F241W	241	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.187	-4.227	2.04	15.032	15.032	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F241X	241	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F241Y	241	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe241Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.5	57.5	31.7	0.917	15.9	-179.9	-132.9	100.7	0.87719298245614	-6.8	0	1	24.22	0	0	0	0	7	30.959838789309	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.187	-3.22	1.033	11.656	11.656	42.43	0.002769842	0	0.0791667	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.495	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E242A	242	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.277	-2.783	0.506	8.41	8.41	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.47	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
E242C	242	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.277	-4.011	1.734	20.027	20.027	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E242D	242	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.277	-2.544	0.267	35.439	35.439	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	T	B	0.142857142857143
E242F	242	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.277	-4.57	2.293	3.617	NA	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E242G	242	E	G	missense	low	0.330833790813963	0.102075107764222	4	0.0510375538821109	0.230802023346003	0.430865558281922	NA	0.267390449337293	0.247765639105819	NA	NA	0.473370843152141	NA	0.334808231660597	0.446906173581222	NA	0.431486020498181	0.41556904731	NA	NA	0.524653299026453	NA	0.462326326664262	p.Glu242Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.277	-3.224	0.947	15.055	15.055	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.82	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
E242H	242	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.277	-3.193	0.916	14.144	14.144	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E242I	242	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.277	-2.802	0.525	9.972	9.972	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.82	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E242K	242	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.277	-2.731	0.454	12.513	12.513	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.27	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
E242L	242	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.277	-2.78	0.503	14.629	14.629	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.82	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E242M	242	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.277	-3.38	1.103	6.431	6.431	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.47	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E242N	242	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.277	-3.12	0.843	9.588	9.588	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.27	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E242P	242	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.277	-3.311	1.034	20.01	20.01	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.015	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E242Q	242	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.277	-3.047	0.77	7.166	7.166	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.47	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E242R	242	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.277	-3.433	1.156	14.342	14.342	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E242S	242	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.277	-2.708	0.431	11.242	11.242	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.015	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E242T	242	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.277	-2.844	0.567	15.56	15.56	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E242V	242	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.277	-2.604	0.327	14.764	14.764	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.92	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
E242W	242	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.277	-4.069	1.792	14.293	14.293	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E242X	242	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E242Y	242	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu242Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	55.9	33.4	0.885	26.3	-126.6	-109.2	131	34.5794392523364	-1	0	1	32.42	0	0	0	0	4	32.9979911185514	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.277	-3.731	1.454	8.742	8.742	89.33	0.002429381	0	0.069435742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.82	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243A	243	F	A	missense	low	0.24856737684466	0.0845863977314049	8	0.0299058077160094	0.189953070792702	0.307181682896619	0.207553926052267	0.274869621448235	0.314735473693781	0.354942432606948	0.253805650742245	0.153339362422782	0.316182310176587	0.113110237614435	0.441674180277988	0.405861999587125	0.434933792970157	0.448414567585819	0.451357831609361	0.474935216584513	0.366918522239966	0.457880975478598	0.350978939921401	p.Phe243Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.078	-2.662	0.584	12.003	12.003	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.115	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
F243C	243	F	C	missense	low	0.325984892034329	0.26790131140458	7	0.101257177983513	0.127524470010482	0.524445314058176	0.723097693501042	0.309293904680785	0.397324516843774	0.52726196847391	-0.114144048454429	0.146492516993636	NA	0.292567692201585	0.450802808194858	0.651145618583659	0.450802808194858	0.488920567160607	0.526928829643816	0.33749208527296	0.363543899115402	NA	0.441111097795793	p.Phe243Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.078	-3.424	1.346	14.871	14.871	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F243D	243	F	D	missense	low	0.236277106813609	0.187834709122732	8	0.0664095982814432	0.106116685954207	0.36643752767301	-0.112073122472509	0.203260299719574	0.130924939441543	0.307010927415669	0.428596194777191	0.477591822740369	0.308254023360004	0.146651769527029	0.416130248470962	0.253790955106644	0.401923100806548	0.358264238458736	0.430337396135375	0.540226096691938	0.526733704590469	0.453610852582264	0.367825109152152	p.Phe243Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.078	-3.298	1.22	9.943	9.943	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243E	243	F	E	missense	low	0.124750038379575	0.187424196636876	6	0.0765156078685676	-0.025217797298007	0.274717874057157	NA	0.0508005317554793	0.191678410334252	0.364333986352469	-0.195882734391317	NA	0.140437099837721	0.197132936388847	0.375643347105895	NA	0.331641713605757	0.38806092785345	0.455476511978784	0.306959594095538	NA	0.36322576635834	0.393179177121857	p.Phe243Glu	0	0	NA	NA	NA	NA	NA	NA	NA	13.977	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.078	-3.268	1.19	10.246	10.246	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243F	243	F	F	synonymous	possibly_wt-like	0.842015646652782	0.333245577635192	8	0.117820103873136	0.611092486406667	1.0729388068989	0.748411361848306	1.15159110960263	1.02301480166936	0.935123887830619	0.983098786891568	0.0668920072723609	0.902680462950365	0.925312755157049	0.753129933290031	0.663189267589486	0.83908764417334	0.795791908012269	0.705797302977166	0.747353790360295	0.324310981765018	0.773765005503679	0.758906076219766	p.Phe243=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	NA	NA	NA	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F243G	243	F	G	missense	low	0.172894992923318	0.113305207723079	8	0.0400594403623698	0.0943799325722433	0.251410053274393	0.161380278108235	0.188835940457372	0.291675657220858	0.363462454273235	0.00024541888901904	0.136469403409399	0.0856217287904467	0.155469062237981	0.382057270256184	0.383893662105266	0.395273713942278	0.437104823815685	0.455094300242225	0.380220878407101	0.358603780161129	0.333702569683564	0.372253577283925	p.Phe243Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.078	-3.028	0.95	17.965	17.965	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F243H	243	F	H	missense	low	0.26540232265645	0.221796438409086	7	0.0838311739586138	0.101096240915855	0.429708404397045	0.209819533036137	0.236655489988122	0.207650647752463	0.231091680893959	0.03708892544752	0.744082193215915	NA	0.191427788261036	0.397042893566039	0.406939922191015	0.417317721494024	0.395894551024208	0.397042893566039	0.393983321808887	0.658079530341455	NA	0.390313777559963	p.Phe243His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.078	-5.113	3.035	3.426	NA	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F243I	243	F	I	missense	possibly_wt-like	0.79028936744105	0.123592181973469	6	0.0504562970053676	0.691396842517274	0.889181892364827	NA	0.808770996399022	0.772919702386384	1.01349359997259	0.741799697459334	0.766027499071752	0.638724709357224	NA	0.671013961511101	NA	0.681053341497793	0.673132150751071	0.740166461020941	0.657219452686967	0.668895772271132	0.631600180603592	NA	p.Phe243Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.078	-2.59	0.512	17.181	17.181	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	1.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
F243K	243	F	K	missense	low	0.212454119560498	0.165153580846551	8	0.0583906084769185	0.0980106299103586	0.326897609210637	0.0374655219052983	0.162896453451917	0.175859722259224	0.237739114810164	0.0672173459709455	0.550577584952839	0.135120289004948	0.332756924128647	0.391637091468974	0.324937930763699	0.383316046982889	0.380302613336146	0.399958135955059	0.405237426560845	0.562706393542626	0.360362167172573	0.461296061442101	p.Phe243Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.078	-3.419	1.341	10.519	10.519	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243L	243	F	L	missense	possibly_wt-like	0.831340748094006	0.250944738058752	8	0.0887223629922128	0.65744811200598	1.00523338418203	0.903269889453714	0.902113251957716	0.942801217257143	1.0292461737614	0.846020818676463	0.268873997480168	0.709090263054099	1.04931037311135	0.730474934585332	0.736867318769308	0.724082550401355	0.756450958024598	0.747074776533996	0.696149983898589	0.423862388606964	0.669498602911647	0.821183638905677	p.Phe243Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.078	-1.952	-0.126	20.593	20.593	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	neutral	neutral	low	1.25	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
F243M	243	F	M	missense	wt-like	0.876625797395076	0.0635132440170344	8	0.0224553227698005	0.832614173505045	0.920637421285107	0.855368672021266	0.844938786317941	0.91488418088397	0.848521265315431	0.759419440718533	0.933417744353873	0.894763501617746	0.961692787931847	0.728418011542224	0.714077044290162	0.69772608396246	0.742758978794286	0.667817589400601	0.663801093307239	0.751397852740332	0.769500982438179	0.777177876993254	p.Phe243Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.078	-3.362	1.284	8.079	8.079	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.86	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
F243N	243	F	N	missense	low	0.132793499968615	0.239383811346185	7	0.0904785761024011	-0.0445412505645575	0.310128250501788	0.142064938254881	0.0307440010975501	0.293449989785716	0.170069741306666	-0.226838407272989	NA	-0.00868067301134496	0.528744909619827	0.370281627912618	0.374703876949247	0.322395990515017	0.437975049591121	0.370281627912618	0.295396479294787	NA	0.282911919139633	0.559730646343653	p.Phe243Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.078	-3.747	1.669	11.553	11.553	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243P	243	F	P	missense	low	0.462628565987149	0.237612242511063	8	0.0840086139862577	0.297974708182956	0.627282423791342	0.376289995804176	0.355879459019453	0.626732375235334	0.500160433446102	0.172698450163568	0.951650003315631	0.318372902563685	0.399244908349241	0.490416090894096	0.486142659459737	0.472277964730649	0.601434216187698	0.515043409688307	0.444638609075972	0.76038403525929	0.4590608140648	0.494689522328456	p.Phe243Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.078	-3.217	1.139	17.31	17.31	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243Q	243	F	Q	missense	low	0.331922345307507	0.180187889965743	8	0.0637060394412363	0.207060802404996	0.456783888210018	0.238409574826545	0.0816653716053851	0.358071703181611	0.473446967646587	0.602826996928291	0.352038667816073	0.439973534805435	0.108945945650128	0.467260455716722	0.420542392748106	0.345869885334921	0.46966892804643	0.503328178090962	0.605307892032042	0.464851983387014	0.524554111161232	0.34888743237369	p.Phe243Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.078	-4.511	2.433	2.247	NA	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243R	243	F	R	missense	low	0.229326999298134	0.111412705629468	8	0.0393903398304688	0.152123351891621	0.306530646704646	0.119937449794039	0.160559588235741	0.150609280553659	0.247862853490272	0.379412316268858	0.239222216977382	0.406275736213975	0.130736552851146	0.393318354301318	0.364176137518242	0.382238791446643	0.367918472026611	0.404397917155993	0.521854057559983	0.409247835787755	0.506404699484995	0.359831722500503	p.Phe243Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.078	-3.779	1.701	8.452	8.452	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F243S	243	F	S	missense	low	0.244443587975689	0.116581951876949	8	0.0412179443680772	0.163657901497482	0.325229274453896	0.243563677766954	0.22266584236796	0.227182440159364	0.29880962201209	0.490997051677619	0.205105612355162	0.0861383621056527	0.18108609536071	0.408171348042357	0.422994593902937	0.410868729380729	0.405473966703984	0.42674070101073	0.563535177220183	0.392432693094498	0.33398082497368	0.38511968239504	p.Phe243Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.078	-3.184	1.106	12.879	12.879	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	1.975	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F243T	243	F	T	missense	low	0.251549692675229	0.233009083481768	8	0.0823811515040104	0.0900856027224305	0.413013782628027	0.0225393237745608	0.0660525571356784	0.294363544472437	0.0214325782326067	0.692826769697828	0.198349489390904	0.453321785033356	0.263511493664458	0.407810231566479	0.317836396177248	0.338672640621168	0.438423104736701	0.305096570965919	0.638926211638717	0.389102784595244	0.531743390540608	0.426517678537714	p.Phe243Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.078	-3.178	1.1	12.57	12.57	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.32	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F243V	243	F	V	missense	low	0.349641109172697	0.110823882248919	8	0.0391821593278152	0.272845488053669	0.426436730291725	0.303904847243266	0.366153009464059	0.434380256423659	0.489660961920655	0.148996729114031	0.427068607804644	0.250416052715173	0.376548408696091	0.480152074032015	0.451703505460293	0.47701389858629	0.507094645881198	0.510438850268969	0.43578511968426	0.501832191738482	0.422459703734897	0.48329024947774	p.Phe243Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.078	-2.517	0.439	14.697	14.697	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.77	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
F243W	243	F	W	missense	low	0.543843369028449	0.112867701908783	7	0.0426599814717156	0.46023134176274	0.627455396294157	0.574366836674804	0.696783521525901	0.505625960121165	0.328414411096989	0.551744934363966	NA	0.608452024429485	0.541515894986834	0.580382969275868	0.580382969275868	0.629429000281096	0.542037276690415	0.439723926891008	0.586226809351388	NA	0.615295512516526	0.566144848929769	p.Phe243Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.078	-4.176	2.098	15.894	15.894	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F243X	243	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe243Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F243Y	243	F	Y	missense	low	0.195864440767823	0.116791981838551	7	0.0441432198673112	0.10934531966626	0.282383561869386	NA	0.259245309067181	0.094325053577076	0.261163632065308	0.177468591041784	0.002427090978214	0.223253965783503	0.353167442861696	0.410230994099323	NA	0.427731247912778	0.340313734315336	0.410230994099323	0.446420437137065	0.29253798506156	0.407830383176445	0.471547204817436	p.Phe243Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41	56.6	32.5	0.495	18.2	-129.2	-71	141.5	6.57894736842105	-1.9	0	1	38.11	0	0	0	0	7	32.5495686278636	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.078	-3.185	1.107	23.076	23.076	72.7	0.002381947	0	0.06808002	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.63	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
P244A	244	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro244Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.208	-2.855	0.647	8.194	8.194	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P244C	244	P	C	missense	low	0.475997765455737	0.194006709349106	5	0.0867624380391289	0.305946511688157	0.646049019223318	0.734432907685388	0.458204167060326	0.47463882708879	0.521914834382457	NA	NA	NA	0.190798091061726	0.524583835746971	0.656538647328815	0.519447933057783	0.52683956099399	0.524583835746971	NA	NA	NA	0.389997513365133	p.Pro244Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.208	-4.274	2.066	12.112	12.112	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P244D	244	P	D	missense	wt-like	0.980811199063954	0.173155395349734	7	0.0654465877520666	0.852538244158864	1.10908415396905	NA	1.16417047539136	1.01215568553495	1.07629505458739	0.687368350779781	1.1577263035077	0.886874792342145	0.881087731304355	0.767708135732278	NA	0.844886520096769	0.790466027765366	0.767708135732278	0.636887285693826	0.861953415676804	0.765252175743924	0.736694143920492	p.Pro244Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.208	-2.479	0.271	28.844	28.844	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.21	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P244E	244	P	E	missense	wt-like	0.958491363952968	0.147540567557251	8	0.052163467909922	0.85625284554081	1.06072988236513	1.07429043123913	1.01372001857712	1.0328392667762	1.04261652795149	0.667235593297413	0.844150668671926	0.890439587108811	1.10263881800166	0.771351771086246	0.818234876793452	0.775531391520238	0.800610341115039	0.752938365970538	0.629366939199852	0.707400549022009	0.767172150652253	0.847967746732838	p.Pro244Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.208	-2.469	0.261	13.416	13.416	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P244F	244	P	F	missense	possibly_low	0.451625282350567	0.238176024420976	2	0.168415881984125	0.121536219237135	0.781714345464	NA	0.283209400366443	0.620041164334692	NA	NA	NA	NA	NA	0.518465393011063	NA	0.43877829069665	0.598152495325476	NA	NA	NA	NA	NA	p.Pro244Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.208	-3.962	1.754	10.712	10.712	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.405	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P244G	244	P	G	missense	possibly_wt-like	0.802840719843257	0.226091236451805	8	0.0799353232309612	0.646170365218005	0.959511074468508	0.942431685012597	0.960648434138114	0.844614460236721	0.980247611559082	0.474976725002492	0.413352330228801	0.923995614246923	0.882458898321324	0.731484595726902	0.755499581532604	0.751066284265218	0.708295021275265	0.725586381563263	0.557550979196185	0.495071813113116	0.785245205160417	0.73738280989054	p.Pro244Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.208	-3.15	0.942	15.182	15.182	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P244H	244	P	H	missense	wt-like	0.791405686130363	0.0584864259522072	7	0.0221057911632192	0.74807913160069	0.834732240660037	NA	0.874393322815679	0.770933546326093	0.816001806201411	0.834641420910544	0.690557148474159	0.768346636340535	0.784965921844124	0.688417151887071	NA	0.711304129581058	0.67215803562072	0.653556130486944	0.691899348377478	0.631698497558097	0.701413694050237	0.688417151887071	p.Pro244His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.208	-3.648	1.44	13.177	13.177	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P244I	244	P	I	missense	possibly_low	0.487919218593761	0.303797711163294	6	0.124024896229249	0.244834888798115	0.731003548389407	0.82278715551783	0.132934323935938	0.231810567488889	0.31506919481112	NA	NA	0.82867063592803	0.596243433880757	0.513751505361429	0.698575523788991	0.369504009525449	0.407743843148748	0.433871361721105	NA	NA	0.733903801660652	0.593631649001752	p.Pro244Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.208	-3.569	1.361	9.702	9.702	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.405	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P244K	244	P	K	missense	possibly_wt-like	0.759735870643532	0.229395352990125	3	0.132441468799698	0.500155361736539	1.01931637955053	0.955221580660937	NA	NA	NA	NA	0.507198859227982	NA	0.816787172041678	0.70439931296901	0.761584713560748	NA	NA	NA	NA	0.541326204306559	NA	0.70439931296901	p.Pro244Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.208	-2.494	0.286	11.207	11.207	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P244L	244	P	L	missense	possibly_low	0.581363026810318	0.228241353750021	8	0.0806955044919189	0.423202744291867	0.739523309328769	0.821458097200547	0.703347684750282	0.68925449153469	0.785942114181173	0.393142976898557	0.191698560194485	0.380219118596196	0.685841171126615	0.632276655566331	0.697943189049433	0.632454969055564	0.632098342077098	0.640373406223274	0.526982978703396	0.385824723231315	0.492370777395045	0.638631938442001	p.Pro244Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.208	-2.978	0.77	23.761	23.761	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P244M	244	P	M	missense	possibly_wt-like	0.756878911593495	0.222695134460948	5	0.0995922917826273	0.561681606561741	0.952076216625249	0.805332833409718	0.982749650228236	0.939469495549407	0.468080478554913	NA	NA	NA	0.588762100225203	0.690271167177339	0.690271167177339	0.761254572929045	0.754816906909225	0.50097469602894	NA	NA	NA	0.589874163709739	p.Pro244Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.208	-3.897	1.689	4.783	4.783	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P244N	244	P	N	missense	wt-like	0.893344168393651	0.0715726643959158	3	0.0413224970556008	0.812353562413411	0.97433477437389	NA	0.886943126191376	0.825187024995633	NA	NA	NA	NA	0.967902353993943	0.717089377729599	NA	0.717089377729599	0.698766787824424	NA	NA	NA	NA	0.780296619482541	p.Pro244Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.208	-2.535	0.327	12.417	12.417	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P244Q	244	P	Q	missense	possibly_wt-like	0.87374504283696	0.246401659640774	7	0.0931310734347241	0.691211493063346	1.05627859261057	NA	0.899260013227754	0.934098046883574	0.988306360953226	0.659638775407645	0.434463718259705	1.152519921002	1.04792846412481	0.729120558530262	NA	0.722767255365592	0.752182466684762	0.729120558530262	0.626529240348479	0.505477039721194	0.908326886893055	0.820489577802287	p.Pro244Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.208	-2.995	0.787	8.653	8.653	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.06	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P244R	244	P	R	missense	possibly_wt-like	0.792271374230751	0.147830068208895	8	0.0522658218468897	0.68983224578846	0.894710502673041	0.959403323896973	0.9053777383501	0.822258401828496	0.748171628702421	0.916930322899916	0.673806126407432	0.80231909194002	0.509904359820647	0.708520735778579	0.763574288800355	0.725587423688378	0.697330437380851	0.623809101604447	0.722637366063866	0.623442376252097	0.719711034176307	0.550268016814851	p.Pro244Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.208	-3.703	1.495	8.708	8.708	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.405	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P244S	244	P	S	missense	wt-like	0.911066976800166	0.13958362967673	8	0.0493502655435239	0.814342233707371	1.00779171989296	0.734783222377952	0.817576720718832	1.00647169782984	0.736703777638083	1.04366263067977	1.03541041556055	0.857444230267875	1.05648311932843	0.759688873231513	0.656705318833748	0.685112632212768	0.787678301999518	0.618779857845855	0.769976677001288	0.80166725495657	0.749401069461737	0.824786136756316	p.Pro244Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.208	-2.543	0.335	14.134	14.134	64.27	0.002393726	0	0.068416674	0	NA	NA	not specified	Uncertain significance(Last reviewed: Mar 21, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.605	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.642857142857143
P244T	244	P	T	missense	possibly_low	0.685854415037881	0.182108383764052	6	0.0743454363508111	0.540140037375377	0.831568792700386	NA	0.71632080009468	0.568450533273539	0.626309927042566	NA	0.890481593016828	0.428749819170341	0.884813817629334	0.605642550092825	NA	0.638435356897522	0.572849743288128	0.570366464527464	NA	0.730235796333303	0.518509092076515	0.738565563537299	p.Pro244Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.208	-2.859	0.651	13.424	13.424	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.06	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
P244V	244	P	V	missense	possibly_low	0.701895925325902	0.135974117123136	3	0.0785046931238643	0.548029554185759	0.855762296466045	NA	NA	NA	NA	0.858845575509115	0.627171567930676	NA	0.619670632537915	0.605397914007458	NA	NA	NA	NA	0.700940515705619	0.600457475969464	NA	0.605397914007458	p.Pro244Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.208	-3.143	0.935	8.885	8.885	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P244W	244	P	W	missense	low	0.430011438490298	0.142112384005551	7	0.0537134323287429	0.324735045639933	0.535287831340664	0.466728528740671	0.294678708759134	0.27131116904255	0.446444583970596	0.558895211460509	0.322956114709369	NA	0.649065752749258	0.491486241113605	0.52917118983103	0.444065448842279	0.427117010444447	0.491486241113605	0.588897708324916	0.450517987205724	NA	0.620161556017875	p.Pro244Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.208	-5.837	3.629	0.723	NA	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.75	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P244X	244	P	X	nonsense	low	0.170739367751335	0.24956862261278	7	0.0943280729254782	-0.0141402579136699	0.35561899341634	NA	0.118420774816605	0.0182983438796044	0.109576484280591	0.491073597485415	-0.0838791416981843	0.550578886667146	-0.00889337117183151	0.343752216811229	NA	0.362813507638067	0.303026247340999	0.343752216811229	0.563563769974941	0.25	0.584125422892023	0.289702864465705	p.Pro244Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P244Y	244	P	Y	missense	possibly_wt-like	0.727709726095131	0.262734249541043	3	0.151689689697856	0.430403397461277	1.02501605472898	NA	NA	0.656465976562045	NA	1.01871862480033	NA	0.507944576923014	NA	0.616017134172464	NA	NA	0.616017134172464	NA	0.760659147232931	NA	0.561162865353484	NA	p.Pro244Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.1	53.5	31.7	0.936	99.9	14.8	-57.6	-44.6	53.2467532467532	-0.1	0	1	38.19	0	0	0	0	3	35.7738605389466	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.208	-3.946	1.738	8.348	8.348	64.27	0.002393726	0	0.068416674	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.205	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q245A	245	Q	A	missense	wt-like	0.951881010887485	0.154570044673555	7	0.0584219854780529	0.837376023445179	1.06638599832979	1.03974387914581	0.722722122114979	0.990849140881079	1.15337904881409	0.887709858689298	NA	0.799720204271685	1.06904282229545	0.780016180476031	0.801798438499893	0.641386258617453	0.780016180476031	0.801513440202754	0.711722417340569	NA	0.718311290449284	0.831094223167567	p.Gln245Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.386	-2.797	0.411	11.788	11.788	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q245C	245	Q	C	missense	wt-like	0.830962599153999	0.168185404645017	8	0.0594625200605475	0.714418201405335	0.947506996902662	0.98973470180682	0.861724531123805	0.827535939452396	1.00908811097298	0.523937707214865	0.644534620768616	0.85855625753403	0.932588924358475	0.721849228425839	0.778005246194516	0.705464029821282	0.699918818703557	0.738234427030397	0.575839758129962	0.609015250528025	0.75	0.762560518063336	p.Gln245Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.386	-3.258	0.872	22.066	22.066	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q245D	245	Q	D	missense	wt-like	1.06055746862408	0.109138046866044	4	0.0545690234330222	0.953604148023839	1.16751078922433	1.08115542684551	NA	NA	NA	NA	1.15676887509652	1.10020944174432	0.904096130809978	0.841491302932683	0.821501080505044	NA	NA	NA	NA	0.861481525360322	0.880152808386055	0.74825006786608	p.Gln245Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.386	-2.551	0.165	14.176	14.176	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.005	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245E	245	Q	E	missense	wt-like	0.991988070305652	0.187037200872094	8	0.066127636535404	0.862380284313505	1.1215958562978	1.02447318619771	1.09045438625831	0.926278264762506	1.13289074141387	1.19777930054352	0.601163649849801	1.06699408716582	0.895870946253673	0.793530631392073	0.794533001368473	0.810904643615702	0.748347235288563	0.792528261415674	0.827545083062304	0.587638883424072	0.862263237867636	0.744118984904492	p.Gln245Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.386	-2.597	0.211	10.909	10.909	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
Q245F	245	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.386	-4.666	2.28	5.018	NA	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q245G	245	Q	G	missense	possibly_wt-like	0.713305711890087	0.165171703904548	8	0.0583970159455211	0.598849663832254	0.827761759947919	0.611959850653527	0.693005691814494	0.8518393543602	1.05922413997863	0.692240888735978	0.62182407585186	0.562582329589623	0.613769364136378	0.615060748891249	0.598268842600104	0.627687484363346	0.711838488388233	0.760221659820801	0.638707362936983	0.597821843163913	0.590590397941979	0.602434013419153	p.Gln245Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.386	-2.851	0.465	16.194	16.194	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q245H	245	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.386	-3.365	0.979	17.043	17.043	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	1.8	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
Q245I	245	Q	I	missense	possibly_low	0.579151805567186	0.246734414420598	6	0.100728902885812	0.381726783708763	0.77657682742561	NA	0.779230230571938	0.530761215278293	0.588407598900439	0.862621652532762	0.560444255626107	NA	0.153445880493579	0.560967165266091	NA	0.667435545609567	0.554364924473641	0.553744340105417	0.70235102331396	0.567569406058541	NA	0.371237438183911	p.Gln245Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.386	-3.806	1.42	11.856	7.681	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q245K	245	Q	K	missense	possibly_wt-like	0.890354127584838	0.321791816259904	2	0.227541175407714	0.444381618785808	1.33632663638387	NA	1.11789530299255	NA	0.662812952177124	NA	NA	NA	NA	0.704964683435293	NA	0.82355444441166	NA	0.586374922458926	NA	NA	NA	NA	p.Gln245Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.386	-2.622	0.236	12.169	12.169	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Q245L	245	Q	L	missense	possibly_low	0.669372845132162	0.204565114898995	6	0.0835133584460584	0.505689670349903	0.83305601991442	0.71394445028803	0.579321891710583	0.429417761211662	0.681619804324024	1.03410524665636	NA	NA	0.577827916602307	0.589502593841914	0.646790720391497	0.575281165763661	0.50466077788515	0.594622696453193	0.766406632535451	NA	NA	0.584382491230634	p.Gln245Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.386	-2.908	0.522	27.302	27.302	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.255	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
Q245M	245	Q	M	missense	possibly_low	0.659167137447851	0.308854804516209	6	0.126089445945293	0.412036364564467	0.906297910331235	0.682673019478036	0.82323085958633	0.800876542268277	0.601379088862141	0.0822797667010101	NA	NA	0.964563547791313	0.659378079805602	0.631912507900959	0.687719095074021	0.686843651710244	0.559433007019867	0.41086381047906	NA	NA	0.778619710554686	p.Gln245Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.386	-3.746	1.36	10.249	10.249	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245N	245	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.386	-2.597	0.211	12.339	12.339	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245P	245	Q	P	missense	low	0.27919453720294	0.251696405390284	6	0.102754627216483	0.0777991686137945	0.480589905792085	NA	0.418384986199872	0.226478315193248	0.328826430921317	-0.202739136034013	0.458459807716674	NA	0.445756819220541	0.470498289820171	NA	0.501091960820366	0.405128626880561	0.439904618819975	0.304398468720632	0.517304056880935	NA	0.518050039189324	p.Gln245Pro	1	0	NA	NA	NA	NA	NA	NA	NA	8.028	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.386	-3.174	0.788	27.008	27.008	72.21	0.00221029	0	0.063173772	0	NA	NA	not specified	Uncertain significance(Last reviewed: Nov 23, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.89	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
Q245R	245	Q	R	missense	possibly_wt-like	0.817963592821747	0.299030657858265	7	0.113022965011002	0.596442651974253	1.03948453366924	0.967325100210763	0.903001189429189	1.01877385477189	1.09157562319722	0.225543274807589	0.629281234768952	NA	0.890244872566629	0.741293300326829	0.767343283958114	0.724491874632108	0.793711925163773	0.77440945264663	0.464378150074487	0.601497273139014	NA	0.741293300326829	p.Gln245Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.386	-3.016	0.63	14.598	14.598	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Q245S	245	Q	S	missense	possibly_wt-like	0.866332221475601	0.237733344021644	6	0.0970542312830934	0.676109423613517	1.05655501933768	NA	0.806400591193391	0.880577434233346	1.12030945913306	0.441857418469609	1.04770427515029	0.901144150673916	NA	0.749435354143481	NA	0.679960624590871	0.725933150424791	0.787010720681067	0.545179665381594	0.807726562602844	0.77293755786217	NA	p.Gln245Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.386	-2.704	0.318	9.932	9.932	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245T	245	Q	T	missense	wt-like	0.978654622416889	0.155809267769428	8	0.0550868949057366	0.870686292381502	1.08662295245228	0.866283092921463	0.751171343412497	1.13041289737393	1.09712881411157	1.14327262005708	0.787082165277884	1.03083877179876	1.02304727438192	0.792014794561664	0.719269869471426	0.654500870847761	0.848465568500644	0.776844813080735	0.807184776042593	0.679273042240853	0.842790223893149	0.807993048598928	p.Gln245Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.386	-2.86	0.474	9.092	9.092	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245V	245	Q	V	missense	wt-like	0.800702401205258	0.100202074209614	8	0.035426783081288	0.731267182277821	0.870137620132696	0.626517394554259	0.835622622416883	0.876067880250576	0.896775848270406	0.780445248411131	0.679841490398554	0.892997553341758	0.817351171998499	0.691205600158394	0.60519498016034	0.693431489191003	0.72372142856991	0.688979711125785	0.671655027836699	0.62641704233743	0.768549854364549	0.704682580851452	p.Gln245Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.386	-3.319	0.933	19.441	19.441	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q245W	245	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.386	-5.806	3.42	1.051	NA	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q245X	245	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	4.062e-06	1	246214	NA	NA	NA	0	0	0	0	0	0	1	0	4	0	7	1	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q245Y	245	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln245Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	54.8	34.1	0.972	108.4	-86.7	-126.9	143.4	66.8224299065421	-0.2	0	1	40.53	0	0	0	0	4	35.7610301565825	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.386	-3.588	1.202	12.129	12.129	72.21	0.00221029	0	0.063173772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P246A	246	P	A	missense	wt-like	0.961762270998186	0.135419894104901	6	0.0552849402631233	0.853405779195016	1.07011876280136	NA	1.040550628865	0.967253968009595	1.14757271663839	0.742124746679935	NA	0.909926956128509	0.963144609667685	0.777787485245088	NA	0.787899851315614	0.768443869841997	0.798967064278345	0.657340870866699	NA	0.777667918851036	0.777907051639139	p.Pro246Ala	1	0	NA	NA	NA	NA	NA	NA	NA	2.136	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.001	-2.911	0.91	13.944	13.944	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P246C	246	P	C	missense	low	0.3205683206408	0.166232690629434	8	0.0587721313994792	0.205377059803165	0.435759581478435	0.516317996399528	0.22133823726047	0.369360468409975	0.129680295460688	0.178299149051347	0.338200796119675	0.216714439258572	0.594635183166145	0.452381178156016	0.552764694125861	0.410256725769185	0.475205530749401	0.352568774188386	0.446730681971669	0.458031674340363	0.4043082373975	0.592823908205225	p.Pro246Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.001	-2.736	0.735	21.826	21.826	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P246D	246	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.001	-2.741	0.74	13.88	13.88	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P246E	246	P	E	missense	low	0.250154434862421	0.138607543112626	8	0.0490051668292724	0.15410607282067	0.346202796904172	0.046443679079343	0.214357577989062	0.352240951532493	0.446433652602735	0.280621432606828	0.0784665251692937	0.358271959878707	0.224399700040908	0.43692399043467	0.32920952712974	0.407038759326482	0.466809221542858	0.491481447145382	0.484951925488156	0.330015745536142	0.480550182717138	0.406873856185846	p.Pro246Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.001	-2.617	0.616	10.615	10.615	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P246F	246	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.001	-3.68	1.679	10.617	10.617	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P246G	246	P	G	missense	low	0.410195720248223	0.0888731702074637	8	0.0314214106596219	0.348610887011921	0.471780553484525	0.50783420936759	0.473988155090768	0.473017869357624	0.500706441379925	0.322069282726579	0.316442239719252	0.298133205960623	0.389374358383423	0.507858563845313	0.54872830746506	0.52672408590226	0.526044558283399	0.515282862309197	0.500434265381429	0.447307476117129	0.448159847200329	0.489732057786942	p.Pro246Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.001	-2.547	0.546	19.989	19.989	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.93	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P246H	246	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.001	-3.247	1.246	13.09	13.09	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P246I	246	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.001	-3.564	1.563	8.624	8.624	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P246K	246	P	K	missense	low	0.0639150790736883	0.174418492510219	2	0.123332498818311	-0.17781217673353	0.305642334880906	NA	NA	NA	NA	0.187247577891999	NA	-0.0594174197446226	NA	0.352829350606936	NA	NA	NA	NA	0.450073258641424	NA	0.255585442572448	NA	p.Pro246Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.001	-3.205	1.204	20.145	20.145	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P246L	246	P	L	missense	low	0.267038156658359	0.253762161278637	5	0.11348588854726	0.0446099023522034	0.489466410964514	NA	0.113536849281025	0.648923499283634	NA	0.408140471437487	0.0798529492479287	0.0847370140417199	NA	0.360562100160477	NA	0.360562100160477	0.612317907619163	NA	0.532585110233218	0.330699076101236	0.333226068165309	NA	p.Pro246Leu	1	0	NA	NA	NA	NA	NA	NA	NA	1.417	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.001	-3.191	1.19	15.934	15.934	42.43	0.00234743	0	0.067093458	0	NA	NA	not provided|Hereditary cancer-predisposing syndrome	Pathogenic(Last reviewed: Nov 15, 2016)	criteria provided, multiple submitters, no conflicts	1	0	0	0	0	13	3	0	0	1	0	2	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P246M	246	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.001	-4.128	2.127	6.752	6.752	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P246N	246	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.001	-2.677	0.676	12.653	12.653	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P246Q	246	P	Q	missense	low	0.359694185969476	0.372382529719913	5	0.166534530017412	0.033292504953044	0.686095866985909	0.951220058155485	0.276076187373915	0.308712192087694	0.344292708062081	NA	-0.0818302158317926	NA	NA	0.445460434290778	0.759680883112966	0.435489999555923	0.445460434290778	0.446687378496785	NA	0.251009859603345	NA	NA	p.Pro246Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.001	-3.106	1.105	7.432	7.432	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P246R	246	P	R	missense	low	0.208605977471289	0.188331710803726	8	0.0665853149108894	0.0781011583466878	0.33911079659589	0.16649840650809	0.282213928399575	0.257009023809182	0.434594462205949	-0.120854726123	-0.00588726901599509	0.278705771064938	0.376568222921571	0.42889942361141	0.386328747418426	0.438319394873278	0.420102488098072	0.486289351950234	0.334985393314781	0.288440064085722	0.437696359124748	0.483300201133988	p.Pro246Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.001	-3.361	1.36	9.476	9.476	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P246S	246	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.001	-2.603	0.602	11.242	11.242	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.13	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P246T	246	P	T	missense	low	0.340649088023553	0.0962625693852845	7	0.0363838313082232	0.269338089039855	0.411960087007252	0.499699254768179	0.238958604423623	0.408641622156938	0.333069222877326	0.25653828403863	NA	0.385621903163543	0.262014724736634	0.475955958489729	0.544857887084671	0.41837941848839	0.49447106932795	0.441765301771301	0.475955958489729	NA	0.495280681466217	0.425765929251988	p.Pro246Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.001	-3.337	1.336	9.946	9.946	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P246V	246	P	V	missense	low	0.348359478575729	0.119344400830569	8	0.0421946175619703	0.265659547812826	0.431059409338632	0.384254316798254	0.377480902406864	0.400328335161497	0.535605299504185	0.184890807283612	0.235459758345451	0.234561213744219	0.434295195361749	0.48608388148343	0.489931896377379	0.482235866589481	0.49039379725094	0.53058781032594	0.449192915668167	0.407393422680884	0.413920392219835	0.512293460876575	p.Pro246Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.001	-3.972	1.971	5.599	NA	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P246W	246	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.001	-5.761	3.76	1.098	NA	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P246X	246	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro246Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P246Y	246	P	Y	missense	low	0.274784382455775	0.0593604667136428	3	0.0342717814363435	0.207612925154514	0.341955839757037	0.243830695155533	NA	NA	NA	0.237298343439348	NA	NA	0.343224108772445	0.466553184591349	0.42312163450655	NA	NA	NA	0.468769112874725	NA	NA	0.466553184591349	p.Pro246Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.1	57.6	36.6	0.26	46.8	-128.1	-51.4	127.7	40.2597402597403	-0.2	0	1	33.94	0	0	0	0	7	33.7915805765282	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.001	-3.658	1.657	12.68	12.68	42.43	0.00234743	0	0.067093458	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L247A	247	L	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.028	-2.612	0.584	11.788	11.788	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247C	247	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.028	-3.266	1.238	14.871	14.871	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247D	247	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.028	-3.68	1.652	12.207	12.207	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247E	247	L	E	missense	possibly_low	0.41189877073909	0.423493114990426	4	0.211746557495213	-0.00311685580186744	0.826914397280047	1.03476218245526	0.286600093244747	0.0903313271161307	0.235901480140224	NA	NA	NA	NA	0.419746790744032	0.799428264190447	0.440341343049682	0.338355001338674	0.399152238438382	NA	NA	NA	NA	p.Leu247Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.028	-3.429	1.401	8.182	8.182	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247F	247	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.028	-2.856	0.828	13.199	13.199	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	1	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L247G	247	L	G	missense	low	0.277800111338043	0.0713329722740449	7	0.0269613292737412	0.224956876986184	0.330643345689901	0.188279929473941	0.399218525612739	0.299058770714307	0.27579227696484	0.325004087875322	0.239875844643722	NA	0.217371344081427	0.416646408865776	0.396691884590578	0.492256545052777	0.440725890008245	0.416646408865776	0.50153052612118	0.409569991013912	NA	0.403343878061534	p.Leu247Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.028	-3.188	1.16	15.814	15.814	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247H	247	L	H	missense	low	0.215683577653851	0.228213644270546	5	0.102060244396379	0.0156491743835919	0.41571798092411	NA	NA	0.324953729976332	NA	0.0119167042881158	0.565365607349611	0.0843712400774402	0.091810606577755	0.384580545000619	NA	NA	0.453426136540364	NA	0.384580545000619	0.56999500592086	0.333029064724858	0.340281241619144	p.Leu247His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.028	-5.175	3.147	1.59	NA	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247I	247	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.028	-2.283	0.255	13.812	13.812	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	1.97	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L247K	247	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.028	-3.279	1.251	8.457	8.457	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247M	247	L	M	missense	low	0.528887246277767	0.0595427425310142	3	0.0343770184285697	0.461509528261901	0.596264964293633	NA	NA	NA	NA	0.460242484632576	0.559853928645366	0.566565325555358	NA	0.567278450011574	NA	NA	NA	NA	0.552047183056768	0.567278450011574	0.592735613253024	NA	p.Leu247Met	0	0	NA	NA	NA	NA	NA	NA	NA	3.939	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.028	-3.057	1.029	5.868	5.868	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.595	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L247N	247	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.028	-4.403	2.375	2.333	NA	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247P	247	L	P	missense	low	-0.042831836928187	0.0380460483887221	3	0.0219658962788302	-0.0858842025228366	0.00022052866646257	NA	-0.0655394772585398	-0.0640475439466755	0.0010915104206542	NA	NA	NA	NA	0.278010927401337	NA	0.278010927401337	0.262639503893456	0.2961759643272	NA	NA	NA	NA	p.Leu247Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.028	-2.488	0.46	22.343	22.343	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247Q	247	L	Q	missense	possibly_low	0.515609341668424	0.286943646294716	5	0.128325099765328	0.264096767815871	0.767121915520976	0.378532717475566	0.156736980119903	0.423221328226329	NA	NA	NA	0.800791894447963	0.818763788072358	0.5016217220698	0.487209693769322	0.380476633438051	0.5016217220698	NA	NA	NA	0.71888849569745	0.705392064529786	p.Leu247Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.028	-3.45	1.422	10.139	10.139	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.595	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L247R	247	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.028	-4.399	2.371	3.439	NA	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247S	247	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.028	-3.335	1.307	9.332	9.332	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L247T	247	L	T	missense	low	0.38197865615363	0.24807215441356	7	0.0937624611111849	0.19820760927387	0.565749703033389	NA	0.133059974780394	0.337830549394706	0.464117370320608	0.383526689347858	0.15800205571115	0.876609783857059	0.320704169663632	0.459741604331146	NA	0.369561932450095	0.459741604331146	0.499236668804817	0.523390931541933	0.369216636423573	0.759723509995916	0.455242588930964	p.Leu247Thr	0	0	NA	NA	NA	NA	NA	NA	NA	5.384	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.028	-2.939	0.911	10.251	10.251	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.395	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L247V	247	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.028	-2.421	0.393	13.829	13.829	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
L247W	247	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.028	-4.229	2.201	14.293	14.293	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L247X	247	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L247Y	247	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu247Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.7	60.8	34.7	0.718	16.9	-130.5	-84.5	115.6	7.85340314136126	-6.3	0	1	28.31	0	0	0	0	5	30.5151371922199	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.028	-3.256	1.228	10.711	10.711	47.39	0.002221451	0	0.063492764	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P248A	248	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.048	-2.455	0.407	11.716	11.716	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.16	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P248C	248	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.048	-4.233	2.185	18.588	18.588	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248D	248	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.048	-3.606	1.558	10.336	10.336	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P248E	248	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.048	-2.679	0.631	10.909	10.909	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248F	248	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.048	-3.34	1.292	12.051	12.051	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248G	248	P	G	missense	possibly_low	0.625005132255048	0.397334035228942	3	0.22940091219763	0.175387606327058	1.07462265818304	NA	1.07511420273349	0.476929191807404	0.322972002224246	NA	NA	NA	NA	0.527962876009879	NA	0.803833077179285	0.527962876009879	0.43733715009199	NA	NA	NA	NA	p.Pro248Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.048	-3.183	1.135	15.055	15.055	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P248H	248	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.048	-3.478	1.43	13.792	13.792	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P248I	248	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.048	-2.915	0.867	11.521	11.521	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P248K	248	P	K	missense	wt-like	1.02636558509846	0.0831495749368292	2	0.0587956282906109	0.911128271200458	1.14160289899646	0.967569956807849	NA	NA	NA	NA	NA	NA	1.08516121338907	0.803324717376622	0.767459780977495	NA	NA	NA	NA	NA	NA	0.83918965377575	p.Pro248Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.048	-2.872	0.824	9.9	9.9	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248L	248	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.048	-2.708	0.66	15.561	15.561	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P248M	248	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.048	-3.645	1.597	11.696	11.696	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P248N	248	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.048	-3.379	1.331	9.038	9.038	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248Q	248	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.048	-3.441	1.393	8.918	8.918	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P248R	248	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.048	-3.265	1.217	12.805	12.805	72.21	0.00195833	0	0.055972343	4.062e-06	1	246204	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
P248S	248	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.048	-3.085	1.037	8.131	8.131	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P248T	248	P	T	missense	wt-like	1.11089463434365	0.0524693294535794	4	0.0262346647267897	1.05947563633265	1.16231363235464	NA	NA	NA	NA	1.15333523881955	1.14791556832533	1.04009725046387	1.10223047976584	0.847769719488841	NA	NA	NA	NA	0.810943544795299	0.857117972236754	0.84777677933037	0.847762659647311	p.Pro248Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.048	-2.851	0.803	9.885	9.885	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
P248V	248	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.048	-2.394	0.346	10.489	10.489	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.33	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P248W	248	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.048	-5.744	3.696	0.866	NA	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P248X	248	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P248Y	248	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro248Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	48.2	63.1	36.6	0.485	35.7	177.9	-66	131	58.4415584415584	-0.6	0	1	29.39	0	0	0	0	5	30.2063701536613	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.048	-3.487	1.439	10.002	10.002	72.21	0.00195833	0	0.055972343	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V249A	249	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.54	-2.998	1.458	7.116	7.116	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V249C	249	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.54	-5.045	3.505	1.153	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249D	249	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.54	-3.505	1.965	12.305	12.305	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249E	249	V	E	missense	low	0.269161808759136	0.115538246147104	7	0.0436693523174004	0.18357145098884	0.354752166529431	0.313980311937185	0.301363418694429	0.270877927511207	0.443799851551065	0.161711704150555	0.306551498280012	0.0858479491894966	NA	0.442432599778039	0.456497174978259	0.447146987621729	0.426904526068614	0.490326389634941	0.440534643837653	0.442432599778039	0.333824410495829	NA	p.Val249Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.54	-4.107	2.567	2.843	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V249F	249	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.54	-3.441	1.901	9.469	9.469	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249G	249	V	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.54	-3.336	1.796	13.158	13.158	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V249H	249	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.54	-5.23	3.69	0.725	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249I	249	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.54	-1.869	0.329	14.823	14.823	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.91	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
V249K	249	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.54	-4.082	2.542	1.811	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249L	249	V	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.54	-1.508	-0.032	27.302	27.302	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.13	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V249M	249	V	M	missense	low	0.354515592543612	0.100799398003401	4	0.0503996990017007	0.255733997668619	0.453297187418605	NA	0.236910488161846	0.327993701633039	0.373849168639361	NA	0.479309011740202	NA	NA	0.457283253980193	NA	0.417435271360604	0.454917098124824	0.459649409835562	NA	0.527580060152027	NA	NA	p.Val249Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.54	-3.169	1.629	5.145	5.145	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.95	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V249N	249	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.54	-4.397	2.857	2.152	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249P	249	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.54	-4.361	2.821	1.04	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249Q	249	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.54	-4.499	2.959	1.189	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249R	249	V	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.54	-4.402	2.862	1.778	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249S	249	V	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.54	-3.898	2.358	2.544	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249T	249	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.54	-3.039	1.499	6.773	6.773	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249W	249	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.54	-5.568	4.028	0.538	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V249X	249	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V249Y	249	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val249Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.7	66.6	36.8	0.993	14.7	167.9	-140.9	145.2	1.81818181818182	-6.2	0	1	26.36	0	0	0	0	6	26.8332748254849	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.54	-4.321	2.781	2.196	NA	72.7	0.002529131	0	0.072286779	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
C250A	250	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.375	-2.447	0.072	11.788	11.788	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
C250D	250	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.375	-4.092	1.717	3.526	NA	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C250E	250	C	E	missense	possibly_wt-like	0.955963769591393	0.477308506313742	5	0.213458853271283	0.537592104998458	1.37433543418433	NA	0.984898299445654	1.34356149541699	1.24515902784503	0.14073388207603	NA	NA	1.06546614317326	0.829297843028058	NA	0.762245064057456	0.953004823254067	0.841763691458679	0.432698633751724	NA	NA	0.829297843028058	p.Cys250Glu	0	0	NA	NA	NA	NA	NA	NA	NA	0.986	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.375	-2.805	0.43	11.573	11.573	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250F	250	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.375	-3.161	0.786	15.973	15.973	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C250G	250	C	G	missense	possibly_low	0.593148499517388	0.167471839619033	7	0.0632984056054935	0.469085904251813	0.717211094782964	0.353695281878936	0.452123259980655	0.568093999035145	0.763261435195816	0.840679922569273	NA	0.595567864552485	0.578617733409406	0.584779175187358	0.475392625123758	0.516644737233039	0.572674880193001	0.630426759498635	0.694154957169162	NA	0.608356189133859	0.584779175187358	p.Cys250Gly	1	0	NA	NA	NA	NA	NA	NA	NA	2.88	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.375	-3.313	0.938	29.858	29.858	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
C250H	250	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.375	-3.462	1.087	16.164	16.164	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250I	250	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.375	-3.078	0.703	8.085	8.085	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250K	250	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.375	-2.683	0.308	20.145	20.145	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.675	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C250L	250	C	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.375	-3.121	0.746	15.654	15.654	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250M	250	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.375	-4.966	2.591	2.078	NA	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250N	250	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.375	-3.229	0.854	12.339	12.339	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250P	250	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.375	-3.792	1.417	13.504	13.504	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
C250Q	250	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.375	-2.936	0.561	9.661	9.661	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250R	250	C	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.375	-3.112	0.737	16.562	16.562	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
C250S	250	C	S	missense	possibly_wt-like	0.843458346040745	0.254321576137496	8	0.0899162555444372	0.667225723548949	1.01969096853254	0.623179919875983	0.89010610737835	1.03609838195834	1.17330585831636	0.798882868018152	0.956674183911082	0.912370769530255	0.35704867933744	0.740703887744774	0.603607088076128	0.718547458825216	0.802208782181156	0.810252373221303	0.6785421762112	0.762860316664332	0.778984140602669	0.473496548296002	p.Cys250Ser	1	0	NA	NA	NA	NA	NA	NA	NA	2.596	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.375	-2.547	0.172	8.95	8.95	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	neutral	medium	2.13	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
C250T	250	C	T	missense	wt-like	1.171663224475	0.0347199973291649	3	0.0200455998042564	1.13237457081015	1.21095187813984	NA	1.20801420251448	1.13884420407731	1.1681312668332	NA	NA	NA	NA	0.852600723634014	NA	0.865097740429935	0.852600723634014	0.807983048151251	NA	NA	NA	NA	p.Cys250Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.375	-2.785	0.41	9.946	9.946	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.855	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
C250V	250	C	V	missense	wt-like	1.18347642667351	0.107769283595479	3	0.0622206248942231	1.06152624278526	1.30542661056176	NA	1.12375581941006	1.11878883086931	1.30788462974116	NA	NA	NA	NA	0.842764516461107	NA	0.826256043850224	0.842764516461107	0.869272100843336	NA	NA	NA	NA	p.Cys250Val	0	0	NA	NA	NA	NA	NA	NA	NA	1.318	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.375	-2.771	0.396	8.217	8.217	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
C250W	250	C	W	missense	wt-like	0.92941925168585	0.210549206585869	4	0.105274603292935	0.723084820744957	1.13575368262674	NA	0.629204656062986	0.941833980728352	1.09877104795088	NA	1.04786732200118	NA	NA	0.766770795874688	NA	0.598276280625195	0.755976574487392	0.777565017261984	NA	0.807806923942838	NA	NA	p.Cys250Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.375	-5.604	3.229	1.985	NA	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
C250X	250	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys250Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C250Y	250	C	Y	missense	possibly_wt-like	0.885057592111537	0.214261504615787	4	0.107130752307893	0.675085175951385	1.09503000827169	0.926777383974066	NA	0.586381517537734	1.09648985606634	NA	0.930581610868006	NA	NA	0.749025816339656	0.748051632679312	NA	0.581644038672589	0.776564597045232	NA	0.75	NA	NA	p.Cys250Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	1.978	47.7	69.9	38.4	0.925	52.5	-8.7	-159.5	130.4	27.027027027027	-1.1	0	1	31.71	0	0	0	0	6	25.6150459273451	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.375	-2.672	0.297	22.919	22.919	72.21	0.001787757	0	0.051097069	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.785	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
G251A	251	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.068	-2.843	1.775	7.889	7.116	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	2	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251C	251	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Cys	1	0	yes	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.068	-5.321	4.253	1.329	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251D	251	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.068	-2.052	0.984	19.098	19.098	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	2	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251E	251	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.068	-2.861	1.793	8.624	8.624	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251F	251	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.068	-4.571	3.503	1.661	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251H	251	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.068	-4.834	3.766	1.394	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251I	251	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.068	-4.367	3.299	3.851	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251K	251	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.068	-3.14	2.072	9.282	9.282	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251L	251	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.068	-3.949	2.881	4.748	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251M	251	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.068	-5.082	4.014	1.442	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251N	251	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.068	-3.114	2.046	8.566	8.566	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251P	251	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.068	-4.089	3.021	2.102	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251Q	251	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.068	-3.355	2.287	5.999	5.999	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251R	251	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.068	-3.314	2.246	10.5	10.5	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251S	251	G	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.068	-2.657	1.589	15.88	15.88	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251T	251	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.068	-3.148	2.08	17.879	17.879	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
G251V	251	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.068	-3.958	2.89	5.201	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	5	0	0	0	1	0	2	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G251W	251	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.068	-5.54	4.472	0.408	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G251X	251	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G251Y	251	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly251Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	46.5	73.6	38.1	0.694	112.3	7.6	91.3	-137.3	9.27835051546392	-3.5	0	0	27.88	0	0	0	0	6	22.3883683608252	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.068	-4.61	3.542	1.345	NA	72.21	0.001710535	0	0.048889942	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252A	252	D	A	missense	low	0.224812435046792	0.12450634771985	7	0.0470589761022367	0.132578536737077	0.317046333356507	NA	0.19914598141481	0.272743576744449	0.394352277813189	0.0118319184928689	0.155862177717719	0.3296035064907	0.21014760665381	0.400026469310214	NA	0.400026469310214	0.427819538328911	0.46864107996327	0.38454887429885	0.368161949000714	0.465109543138034	0.399715769974483	p.Asp252Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-0.896	-3.429	2.533	4.069	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D252C	252	D	C	missense	low	0.339534149827248	0.157989088906088	6	0.0644987754578537	0.213118872882919	0.465949426771578	0.428440439617485	0.148183182852083	0.218524498986475	0.377602481074961	0.585535208668078	NA	NA	0.278919087764408	0.447775771762876	0.510954616074215	0.376533476854221	0.401227658136991	0.461295430788824	0.598848755009648	NA	NA	0.434256112736929	p.Asp252Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-0.896	-3.551	2.655	12.832	12.832	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252E	252	D	E	missense	low	0.258352575650627	0.111548724397981	7	0.0421614548319343	0.175717642644224	0.34098750865703	0.238682829863414	0.276265750514727	0.337329559159956	0.427873889851019	0.0782984769682998	NA	0.178463146660015	0.271554376536959	0.43055720083283	0.420672401078308	0.435577384973573	0.459495892436907	0.483342034586189	0.409376648161175	NA	0.383706343934485	0.43055720083283	p.Asp252Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-0.896	-2.157	1.261	8.993	8.993	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.92	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D252F	252	D	F	missense	low	0.204950557562182	0.124666609534673	8	0.0440763024947515	0.118562592100776	0.291338523023588	0.144552661586649	0.281662293929456	0.21725466680952	0.335688755403005	0.121472593944015	0.110360610499362	0.0327506799865493	0.3958621983389	0.413054339922385	0.375887477295922	0.438065100666318	0.400604865819051	0.442914101797679	0.425503814025718	0.345735469167336	0.305226572122717	0.492990562798484	p.Asp252Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-0.896	-4.525	3.629	0.991	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252G	252	D	G	missense	low	0.287563093557784	0.120108998950666	8	0.0424649438197718	0.204333333065514	0.370792854050053	0.278521023833183	0.298625879495314	0.432322546416551	0.397350063478456	0.0346985047146324	0.269893542550725	0.335900718983444	0.253192468989963	0.442755753222706	0.439626478322897	0.445885028122515	0.506085436941441	0.46995576348698	0.393090409241225	0.424364894528449	0.468501180180239	0.421334968445169	p.Asp252Gly	1	0	yes	0.162100709900347	-1.85126147341928	0.131811163710271	0.192390256090423	NA	NA	3.473	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-0.896	-3.41	2.514	2.574	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	Macrocephaly/autism syndrome	Pathogenic(Last reviewed: Apr 1, 2005)	no assertion criteria provided	1	0	0	0	0	4	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	A	D	D	D	D	0.928571428571429
D252H	252	D	H	missense	low	0.222843067338306	0.16344091868644	6	0.0667244756455825	0.0920654981856442	0.353620636490967	NA	0.310193292339589	0.26609226468823	0.379921738276116	0.0296720216446117	NA	0.00586983071155966	0.345309256369728	0.437887398361225	NA	0.451217410769269	0.42455738595318	0.462312544608845	0.391212827674678	NA	0.290748724307984	0.467600445920571	p.Asp252His	1	0	NA	NA	NA	NA	NA	NA	NA	8.695	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-0.896	-4.673	3.777	0.994	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D252I	252	D	I	missense	low	0.263376405309185	0.159074857495363	5	0.0711404389741449	0.123943707075491	0.402809103542878	NA	0.176706155701243	0.205459216862689	0.260011679617261	0.536597142702198	NA	NA	0.138107831662532	0.394819758348281	NA	0.38968208730863	0.394819758348281	0.409725803577835	0.580568536160803	NA	NA	0.363533932960873	p.Asp252Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-0.896	-4.222	3.326	1.899	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252K	252	D	K	missense	low	0.0563653617499766	0.211753073671724	3	0.122255694086101	-0.183251395563727	0.29598211906368	NA	NA	NA	NA	-0.101713566798026	NA	-0.0261428557026851	0.296952507750641	0.34213534038717	NA	NA	NA	NA	0.34213534038717	NA	0.273506902916671	0.44331336288546	p.Asp252Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-0.896	-3.623	2.727	2.976	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252L	252	D	L	missense	low	0.187494061384016	0.0768505874152355	8	0.0271707857497413	0.134240299882869	0.240747822885163	0.144571501373633	0.217021731243649	0.300563857562134	0.235285214313957	0.116284111500288	0.0685064734049265	0.250194981076478	0.167524620597062	0.403574431625402	0.375896440824189	0.408266889140323	0.441464063558789	0.39888197411048	0.423565719565041	0.325106708030663	0.422340636010941	0.378308458045409	p.Asp252Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-0.896	-3.932	3.036	2.669	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252M	252	D	M	missense	low	0.227837960978434	0.133201360146502	4	0.0666006800732511	0.0973030266889869	0.35837289526788	0.198420839950667	NA	0.161822122836889	0.422949529171285	NA	NA	NA	0.128159351954892	0.387467264904727	0.401516691675261	NA	0.373417838134193	0.481182448620635	NA	NA	NA	0.358537328357949	p.Asp252Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-0.896	-5.07	4.174	0.77	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252N	252	D	N	missense	low	0.325756304197102	0.190738913938553	8	0.0674363897410541	0.193583409057229	0.457929199336974	0.0360699808062658	0.397996049335142	0.517998316381471	0.539762300796091	0.249420185296791	0.0961995981590004	0.477571360809321	0.291032641992731	0.482495041705727	0.324273965077675	0.491693004062541	0.548105329283165	0.532410869649303	0.473297079348914	0.338755892922252	0.544804051833885	0.440340121811052	p.Asp252Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-0.896	-2.949	2.053	9.824	9.824	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D252P	252	D	P	missense	low	0.197543922388019	0.161994716899149	8	0.0572737814178915	0.0852893735505322	0.309798471225505	0.105146321554989	0.17039621001883	0.261660375862544	0.371766980039084	0.00680579004089437	0.472174126194337	0.034502068501968	0.157899506891504	0.384722366869099	0.357138866014662	0.386773308542641	0.422383755165829	0.458736262815827	0.382671425195557	0.524063469920311	0.306169858405501	0.373474263388719	p.Asp252Pro	0	0	NA	NA	NA	NA	NA	NA	NA	-0.686	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-0.896	-3.101	2.205	35.969	35.969	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D252Q	252	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp252Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-0.896	-3.88	2.984	1.972	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252R	252	D	R	missense	low	0.202352428495965	0.128142572736974	8	0.0453052410705023	0.113555787686876	0.291149069305054	0.229348631250549	0.272195998501695	0.373678153927262	0.134001671833618	-0.0533276934844472	0.161428048482041	0.293062345934449	0.208432271522553	0.40754282739685	0.416231408555935	0.433701297787697	0.477323150242941	0.354463920456868	0.360209294392246	0.370905214696426	0.445428715493971	0.398854246237765	p.Asp252Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-0.896	-4.081	3.185	1.807	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252S	252	D	S	missense	low	0.336287205130513	0.157721340465988	8	0.055762914690666	0.226993900663829	0.445580509597198	0.496910731179466	0.231595489785537	0.354813031319035	0.461739829047361	0.256153780642985	0.0569461349503866	0.52585806836361	0.306280575755726	0.471941518167048	0.543531173038875	0.414985146558204	0.468070704407489	0.498193994415152	0.475812331926607	0.319408932919454	0.570810953486949	0.447998366916257	p.Asp252Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-0.896	-2.699	1.803	6.494	6.494	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252T	252	D	T	missense	low	0.124511340931345	0.0976286017256867	2	0.0690338463179938	-0.0107925115661962	0.259815193428885	NA	0.0554774946133508	NA	NA	0.193545187249338	NA	NA	NA	0.39311168436599	NA	0.333797714772013	NA	NA	0.452425653959967	NA	NA	NA	p.Asp252Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-0.896	-3.626	2.73	2.549	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252V	252	D	V	missense	low	0.330856866470537	0.167241270110504	7	0.0632112585227106	0.206965076348574	0.4547486565925	0.139984480669125	0.277797369768034	0.253079716331861	0.354652186547907	0.552714043151262	0.555756573115715	NA	0.182013695709853	0.436283435672872	0.373714044081461	0.436283435672872	0.418175349570549	0.45123054375284	0.586588808142523	0.565258975369855	NA	0.385585567868037	p.Asp252Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.532	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-0.896	-3.922	3.026	2.349	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	1	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D252W	252	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp252Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-0.896	-5.726	4.83	0.267	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D252X	252	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp252Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D252Y	252	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp252Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.9	74.7	35.4	0.727	70.7	-179.2	-87.2	123.7	6.95187165775401	-2.1	0	1	23.53	1	154	0	0	5	18.8504763297907	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-0.896	-4.569	3.673	0.853	NA	72.7	0.001097972	0	0.031381866	0	NA	NA	NA	NA	NA	0	0	0	0	0	7	0	2	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.265	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253A	253	I	A	missense	low	0.217387278092012	0.132217657165679	8	0.0467460009872248	0.125766799735778	0.309007756448247	0.308201668039764	0.287766603621043	0.316940174189196	0.383362716429969	0.0147355035968309	0.0510731391038861	0.162863413464241	0.214155006291169	0.421303781678566	0.453747831901014	0.4408790847013	0.449495868372506	0.463821590881475	0.385633473170895	0.316514293658327	0.375304430704423	0.401728478655831	p.Ile253Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.535	-2.969	1.434	9.344	9.344	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I253C	253	I	C	missense	low	0.353517099144079	0.203403454408708	5	0.0909647901832301	0.175229386523705	0.531804811764453	0.50289443641604	NA	NA	NA	0.0219701941185291	0.531967193224452	0.381868047915997	0.328885624045379	0.49325887983203	0.546378079486214	NA	NA	NA	0.388335903751877	0.553533839709809	0.49325887983203	0.459351708497349	p.Ile253Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.535	-5.037	3.502	1.634	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253D	253	I	D	missense	low	0.216364416034944	0.281210778285783	6	0.114803819495183	-0.00864693546325235	0.441375767533141	NA	NA	0.616218392529584	0.456743933667048	-0.0866040712709894	-0.0729926047004925	0.215508223646736	0.169312622337779	0.391432528042051	NA	NA	0.596277607480717	0.496003036796409	0.347779308522781	0.255365676774657	0.403658577638567	0.379206478445535	p.Ile253Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.535	-4.244	2.709	1.581	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253E	253	I	E	missense	low	0.311777115856877	0.174356441890192	8	0.0616443112020564	0.190956486049067	0.432597745664686	0.229865173335887	0.22417795965757	0.353337698031113	0.405136666567694	0.683343869249869	0.11275621800915	0.222953137278075	0.262646204725656	0.421280128000314	0.416477167151142	0.411565790002973	0.467347123563663	0.473370590272529	0.635383989605844	0.34691619868483	0.407668358931029	0.426083088849487	p.Ile253Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.535	-4.098	2.563	2.041	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253F	253	I	F	missense	possibly_wt-like	0.74381539381583	0.264427325527789	7	0.0999441347423502	0.547928489254805	0.939702298376855	0.939944824925441	0.963337071980951	0.816644741521694	0.792281574528422	0.76197391343227	0.174012359428091	NA	0.758513270893941	0.675131359345752	0.754316391897446	0.752305701062177	0.694577203860668	0.643153586328978	0.664755285495444	0.377107677883994	NA	0.675131359345752	p.Ile253Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.535	-2.296	0.761	16.356	16.356	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253G	253	I	G	missense	low	0.26280897091294	0.131267730880067	8	0.046410151328133	0.171846745792745	0.353771196033134	0.446786190750875	0.177693683219241	0.311288895601787	0.397316726376228	0.0529390548169859	0.20983454375061	0.1756810201117	0.33093165267609	0.423314064787516	0.519683093684324	0.390137320874774	0.446724184873971	0.469941143449419	0.399903944701061	0.39476345423212	0.382207908957383	0.46037932240162	p.Ile253Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.535	-3.974	2.439	2.528	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253H	253	I	H	missense	low	0.311384992202883	0.0773381883632384	8	0.0273431787181642	0.257793346692439	0.364976637713327	0.403351398169849	0.228101323533339	0.314191940277951	0.402204935899624	0.223351919223678	0.386863328536312	0.247227171510321	0.285787920471988	0.455853793076896	0.499017839272735	0.413374394721218	0.448147990283664	0.472084875269644	0.463559595870129	0.482016107593961	0.420742193387258	0.437705970617933	p.Ile253His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.535	-5.14	3.605	0.984	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253K	253	I	K	missense	low	0.118859736889252	0.131344027616443	8	0.0464371262979699	0.0278446417996936	0.209874831978811	0.305285117294754	-0.0384327161834546	0.122951887950592	0.0398388291840587	-0.00132531054733496	0.110498047569193	0.0935802336239909	0.318481806222221	0.350078521934162	0.452360205540476	0.290506688062117	0.354353835722677	0.313168660688513	0.379634151545666	0.345803208145647	0.33798896780418	0.454126411210644	p.Ile253Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.535	-4.069	2.534	3.297	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253L	253	I	L	missense	possibly_wt-like	0.8381319439467	0.201576390855233	8	0.0712680164504225	0.698449198454264	0.977814689439136	0.580913119540378	1.03192038361153	1.0078119021917	1.05675791518435	0.607394246484291	0.631323601954125	0.924218724102126	0.864715658505106	0.743805697652437	0.583497536949121	0.783921453496985	0.788335608528821	0.759140093136304	0.607013932509391	0.602503900147505	0.785365370654317	0.72847130216857	p.Ile253Leu	1	0	NA	NA	NA	NA	NA	NA	NA	-0.565	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.535	-2.514	0.979	12.677	11.834	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.945	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
I253M	253	I	M	missense	possibly_wt-like	0.87490756238372	0.226687472911039	6	0.0925447732855049	0.693523139786706	1.05629198498073	1.04157262161391	1.00464332920573	0.947412697249229	1.01100374064656	0.447714340558742	NA	NA	0.797098645028148	0.748893599558925	0.802668511225254	0.771347190476708	0.758712669741724	0.739074529376127	0.547367447335311	NA	NA	0.694510788531949	p.Ile253Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.535	-3.598	2.063	10.41	10.41	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253N	253	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile253Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.535	-4.385	2.85	1.472	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253P	253	I	P	missense	low	0.361607331467963	0.124964918060081	8	0.0441817704853522	0.275012652543458	0.448202010392469	0.209058150001014	0.396026432527625	0.499684870230252	0.521737177867583	0.32550903982229	0.198904761127943	0.292865926201368	0.449072293965633	0.496252094318281	0.406577674021045	0.490785043862059	0.539123454524464	0.524505924208568	0.501719144774503	0.38937646286995	0.445322925123501	0.519715229937965	p.Ile253Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.535	-4.356	2.821	1.496	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253Q	253	I	Q	missense	low	0.347282011512527	0.203814429500206	6	0.0832068924153265	0.184199499112988	0.510364523912066	NA	0.21638330162822	0.410695289138424	0.447590226636018	0.124543751828846	NA	0.208961077709769	0.675518422133887	0.459319836070248	NA	0.407972583832099	0.495478295355836	0.491988664470198	0.426651007670298	NA	0.400132328094641	0.633447357817859	p.Ile253Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.535	-4.517	2.982	1.903	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253R	253	I	R	missense	low	0.227770317242894	0.160070586242657	8	0.0565934985003445	0.116849098423097	0.33869153606269	0.41578556992038	0.216416924605493	0.336790473451105	0.37843112312817	0.0220180564207715	-0.0101728740753173	0.159622351202407	0.30327091329014	0.427237426624778	0.504933726223105	0.407988083458762	0.459231496523591	0.461658833038367	0.388353782132281	0.286327806391927	0.373558815984259	0.446486769790794	p.Ile253Arg	0	0	NA	NA	NA	NA	NA	NA	NA	11.13	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.535	-3.552	2.017	9.391	9.391	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253S	253	I	S	missense	low	0.293899248946893	0.119503911142789	8	0.0422510129736904	0.211088785208125	0.37670971268566	0.339186009563385	0.328564212068173	0.372495531503771	0.432460435357849	0.0360304006160508	0.233428183249181	0.282597714387786	0.326431504828946	0.458902613739501	0.468489454050279	0.459686095589669	0.476743130163328	0.485353471187023	0.393587922742857	0.406392114798282	0.439792534083929	0.458119131889334	p.Ile253Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.535	-3.873	2.338	3.094	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253T	253	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile253Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.535	-2.705	1.17	8.238	8.238	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I253V	253	I	V	missense	wt-like	0.954060934310829	0.0651085113888123	8	0.0230193349579954	0.908943866845094	0.999178001776564	0.973556605323482	0.911727873851466	0.919833424591409	0.990217724988569	1.02507097250845	1.04985105201797	0.890126173894448	0.872103647310843	0.754109168476703	0.770308087767899	0.728514729284528	0.745186347557294	0.729958790173769	0.763031989396111	0.808784650292412	0.767003348365754	0.732181905191135	p.Ile253Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.535	-1.481	-0.054	23.583	23.583	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.45	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
I253W	253	I	W	missense	low	0.29961558079616	0.230179413484349	8	0.0813807120821627	0.140112316078898	0.459118845513422	0.737429818025706	0.280191320729527	0.406467995012826	0.453070293021625	0.0172500544214249	0.0856975860089749	0.179040567741142	0.237777011408054	0.4254897958022	0.657964506897865	0.437387006776981	0.493405008542923	0.49439195602952	0.386572753023355	0.33357973794363	0.384017339113694	0.413592584827419	p.Ile253Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.535	-5.46	3.925	0.76	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I253X	253	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile253Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I253Y	253	I	Y	missense	low	0.349021779072327	0.14452108759764	8	0.0510959205323733	0.248875615071955	0.449167943072699	0.150957194273569	0.166666921023759	0.262750644844083	0.38417972848569	0.558585089293013	0.401722418407239	0.388808218294662	0.478504017956599	0.476759819983524	0.378934603562627	0.385054169078202	0.422918480272432	0.464179892777696	0.588781865964172	0.489339747189352	0.496996809743497	0.534497256125577	p.Ile253Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.4	71.8	33.5	0.947	13.5	-153.7	-128.8	143.9	3.66492146596859	-6.8	0	1	22.87	0	0	0	0	7	19.4708864169046	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.535	-4.137	2.602	3.793	NA	87.59	0.001936628	0	0.055352047	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254A	254	K	A	missense	low	0.500138881795776	0.107750974736228	3	0.0622100542694059	0.378209415951459	0.622068347640094	NA	NA	NA	NA	NA	0.429367602652544	0.624146426633135	0.44690261610165	0.518625513446539	NA	NA	NA	NA	NA	0.502965303513425	0.623748413848742	0.518625513446539	p.Lys254Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.577	-3.488	1.911	2.757	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254C	254	K	C	missense	possibly_wt-like	0.817260320671878	0.185153478521192	8	0.0654616401113063	0.688957863684796	0.945562777658961	1.06106552956368	0.763011828434573	0.504855503361222	0.660192796368664	0.956526483209196	0.73891829291988	0.980657107829305	0.87285502368851	0.696259208844833	0.811942779112046	0.659959135172797	0.541659404275378	0.585225849090925	0.737428029767909	0.655534384911742	0.815762711235064	0.732559282516868	p.Lys254Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.577	-3.915	2.338	13.192	13.192	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254D	254	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.577	-4.07	2.493	2.068	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254E	254	K	E	missense	low	0.134815612803424	0.106782108802672	5	0.0477544108127108	0.0412186875075802	0.228412538099267	0.0313275469815776	0.247895834839602	0.172482018772568	0.0122486880424835	NA	NA	NA	0.210123975380886	0.37864601034408	0.322017626421643	0.42249933130051	0.37864601034408	0.301068961768768	NA	NA	NA	0.399703901213574	p.Lys254Glu	1	0	NA	NA	NA	NA	NA	NA	NA	2.167	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.577	-3.714	2.137	3.691	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.765	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K254F	254	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.577	-3.585	2.008	8.895	8.895	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254G	254	K	G	missense	low	0.437035720283584	0.0846439455021697	8	0.0299261539254844	0.378381536393833	0.495689904173335	0.440468811954514	0.462748096035942	0.530919736467858	0.528677568542888	0.264492395683611	0.40018797963772	0.410689702933586	0.458101471012555	0.519110020517748	0.516677433192274	0.521542607843221	0.554442671581395	0.527549643235799	0.478927120074246	0.488583464225404	0.508782032796606	0.524250116565781	p.Lys254Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.577	-3.874	2.297	1.83	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254H	254	K	H	missense	wt-like	0.870804916516528	0.120873397435564	6	0.0493463578656279	0.774087832331672	0.967522000701384	NA	0.871457493899982	0.730354975633807	0.967683069990308	0.719219101338088	NA	1.00003821153767	0.936076646699313	0.715013472176676	NA	0.709950761859628	0.652256175706662	0.720076182493723	0.64878474586546	NA	0.82620124563927	0.764312219832257	p.Lys254His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.577	-3.518	1.941	13.002	13.002	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254I	254	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.577	-3.361	1.784	5.997	5.997	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K254K	254	K	K	synonymous	possibly_low	0.560170840306278	0.492476950190452	3	0.284331699762144	0.00289094910942078	1.11745073150313	NA	0.600074465511246	NA	NA	0.0489560411166551	NA	NA	1.03148201429093	0.584847753029102	NA	0.584847753029102	NA	NA	0.398416138416057	NA	NA	0.812229380329239	p.Lys254=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K254L	254	K	L	missense	possibly_low	0.654862839867561	0.117671667018848	8	0.0416032168512763	0.57332203319805	0.736403646537073	0.756705765631174	0.557367701450713	0.55355240686369	0.497578611113087	0.814120084167094	0.591159997623265	0.730064189047277	0.738353963044191	0.623857371294982	0.667135550147315	0.565160653533201	0.565542920506243	0.513911147525043	0.68423385283046	0.58270835644152	0.680795020874499	0.665006386148443	p.Lys254Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.577	-2.006	0.429	11.834	11.834	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254M	254	K	M	missense	possibly_low	0.599453017049782	0.411289108034123	5	0.183934080793911	0.238948843164237	0.959957190935327	NA	0.867353190664697	0.641466451113099	0.728746024541324	-0.115090379179514	NA	NA	0.874789798109303	0.61528997296073	NA	0.708058747141775	0.608660579982175	0.61528997296073	0.337138594949701	NA	NA	0.733531019210378	p.Lys254Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.577	-2.771	1.194	8.32	8.32	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.765	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K254N	254	K	N	missense	possibly_low	0.696943358129794	0.104564192322134	6	0.0426881527592458	0.613276116155128	0.78061060010446	NA	0.780719399339641	0.62679827385815	0.630503379207393	0.6929503783166	NA	0.589907758988954	0.860780959068025	0.62214003890397	NA	0.668122027349425	0.601466536329522	0.572205509437325	0.638972384133648	NA	0.605307693674291	0.726495107021552	p.Lys254Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.577	-3.427	1.85	7.859	7.859	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K254P	254	K	P	missense	low	0.298024079055827	0.180134893954022	6	0.0735397625096186	0.153888793105346	0.442159365006308	0.173383431012379	0.465914468410116	0.302468226324649	0.482926481080503	0.0125200529515751	NA	NA	0.350931814555739	0.456411215376115	0.389604480409339	0.523002252219065	0.442398065907558	0.507485433317294	0.384805918549666	NA	NA	0.470424364844672	p.Lys254Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.577	-4.255	2.678	1.018	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254Q	254	K	Q	missense	possibly_wt-like	0.819161336673448	0.313723673530929	3	0.18112844736424	0.464156103263879	1.17416657008302	NA	0.479569073063694	0.879731261888316	1.09818367506833	NA	NA	NA	NA	0.725518143114612	NA	0.52929679516339	0.725518143114612	0.77730742397908	NA	NA	NA	NA	p.Lys254Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.577	-3.09	1.513	7.644	7.644	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K254R	254	K	R	missense	possibly_wt-like	0.808354866728395	0.215141645613358	7	0.0813158987065908	0.648978633892969	0.96773109956382	0.989994921940996	0.844167962041142	0.964309375427571	0.964802011551335	0.528003910055476	0.477545163682754	NA	0.889660722399488	0.718812689875006	0.778129052824092	0.697370746943489	0.76699968715957	0.718812689875006	0.577358638705709	0.52671070761523	NA	0.740999912040406	p.Lys254Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.577	-2.168	0.591	18.867	18.867	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	1.96	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
K254S	254	K	S	missense	low	0.526591354269105	0.214756808976912	8	0.0759279979667792	0.377775212835988	0.675407495702223	0.766378995161943	0.459878423404778	0.576218276386662	0.496221831458621	0.0712428021500073	0.480695934138784	0.667864364971973	0.694230206480073	0.552461544175079	0.671737845619594	0.52021973705558	0.576659452024743	0.513316129716499	0.406741086717153	0.528263636325414	0.647294606588733	0.642845315148091	p.Lys254Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.577	-3.735	2.158	2.408	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254T	254	K	T	missense	low	0.282426270479663	0.239555132758546	8	0.0846955294208058	0.116426083163332	0.448426457795995	0.454302130581535	0.395919181999395	0.447517722233683	0.495516454980258	0.00353372371661389	-0.0746037410099054	0.0673799747488337	0.469844716586893	0.501871194474153	0.523259001372913	0.490735603173524	0.513537948336563	0.513006785774782	0.381449184648955	0.254571591687907	0.32387768148206	0.530148138837962	p.Lys254Thr	1	0	NA	NA	NA	NA	NA	NA	NA	0.811	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.577	-3.119	1.542	5.675	5.675	54.84	0.00207307	0	0.059251787	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Feb 17, 2015)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K254V	254	K	V	missense	low	0.337975375715033	0.179693773719351	8	0.0635313429669772	0.213456231610296	0.462494519819771	0.312815190596832	0.181500187668543	0.396352789743371	0.561707330762707	0.00398487215295981	0.490389962047315	0.310046729155072	0.447005943593468	0.472193409407197	0.455942837602896	0.391892055364111	0.488443981211497	0.542034896362987	0.381617705655802	0.533041557937467	0.45457639207888	0.518677409478535	p.Lys254Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.577	-3.044	1.467	6.814	6.814	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254W	254	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.577	-5.541	3.964	0.689	NA	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K254X	254	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K254Y	254	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys254Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	71.7	30.6	0.93	5	-168.9	-116.8	139.8	18.695652173913	-6.2	0	1	17.79	0	0	1	2	7	17.6372814758964	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.577	-3.591	2.014	7.955	7.955	54.84	0.00207307	0	0.059251787	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255A	255	V	A	missense	low	0.187201879318678	0.311004797460544	4	0.155502398730272	-0.117577221702242	0.491980980339598	NA	-0.0896769293561585	NA	NA	0.62855703103568	0.0540251478462889	NA	0.155902267748901	0.345220206029051	NA	0.266883968207008	NA	NA	0.614919033077118	0.31796925814805	NA	0.372471153910051	p.Val255Ala	1	0	NA	NA	NA	NA	NA	NA	NA	6.322	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.446	-2.997	1.551	11.572	11.572	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.27	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
V255C	255	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.446	-5.04	3.594	1.173	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255D	255	V	D	missense	low	0.348373431512275	0.0548859346125432	4	0.0274429673062716	0.294586203963072	0.402160659061477	0.314552200640928	0.297329773966004	0.361762441192296	0.419849310249871	NA	NA	NA	NA	0.464124162893252	0.456769266194901	0.445287545286387	0.471479059591603	0.47982284283457	NA	NA	NA	NA	p.Val255Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.446	-4.301	2.855	1.322	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255E	255	V	E	missense	low	0.31129551317858	0.190357388861605	8	0.0673015002565027	0.179386996570322	0.443204029786839	0.356607958466088	0.518658202894421	0.479225717381082	0.493281238649363	0.248076970508151	-0.0365844136149699	0.171232439387511	0.259865991756995	0.474786873032847	0.476778408250957	0.54731622616254	0.529089212632305	0.512026528207938	0.472795337814737	0.273310279852413	0.379811932771606	0.424686732288027	p.Val255Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.446	-4.144	2.698	1.608	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V255F	255	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.446	-2.327	0.881	14.251	14.251	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.615	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255G	255	V	G	missense	low	0.291130994203838	0.123669492075037	8	0.0437237682360775	0.20543398319275	0.376828005214926	0.437189853147243	0.198133030210042	0.285981258629346	0.416474807698846	0.180567205844349	0.0917999557370673	0.364306892385733	0.354594949978078	0.459921027235995	0.515117381585466	0.399559515852338	0.434311992004963	0.478342949540013	0.447577886979048	0.336587429326789	0.483800557491948	0.472264167492943	p.Val255Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.446	-4.012	2.566	3.131	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V255H	255	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.446	-5.18	3.734	0.632	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255I	255	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.446	-1.639	0.193	19.741	19.741	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V255K	255	V	K	missense	low	0.35374960173093	0.126135190857036	6	0.0514944760347179	0.252822283300122	0.454676920161738	0.381157392173483	0.250523984202122	0.550134532990585	NA	0.410353666435762	0.19209609045743	NA	0.338231944126199	0.476252165978978	0.488458452360235	0.423710863926037	0.563866615849229	NA	0.533411822284975	0.386020655041363	NA	0.46404587959772	p.Val255Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.446	-4.113	2.667	1.801	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255L	255	V	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.446	-2.156	0.71	14.722	14.722	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.27	Neutral	DAMAGING	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
V255M	255	V	M	missense	low	0.0314646336196578	0.103511902426994	3	0.0597626247305553	-0.0856679584738133	0.148597225713129	NA	0.150746839607214	-0.021578708760689	-0.0347742299875518	NA	NA	NA	NA	0.283468448682913	NA	0.377715279473124	0.283468448682913	0.280446988594667	NA	NA	NA	NA	p.Val255Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.446	-2.828	1.382	4.783	4.783	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V255N	255	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.446	-4.452	3.006	1.232	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255P	255	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.446	-4.383	2.937	1.161	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255Q	255	V	Q	missense	low	0.235025654729581	0.26984394455404	2	0.190808483056288	-0.138952100005465	0.609003409464627	NA	0.0442171716732927	0.425834137785869	NA	NA	NA	NA	NA	0.415755038177402	NA	0.328606895402915	0.502903180951889	NA	NA	NA	NA	NA	p.Val255Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.446	-4.528	3.082	1.036	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255R	255	V	R	missense	low	0.279687097680459	0.239507725255191	7	0.0905254111577172	0.102260552125653	0.457113643235264	0.144362239781816	0.526908580522237	0.395447099999284	0.307225983484538	-0.0478321124751406	0.0506042817848018	NA	0.581093610665673	0.430431709305824	0.375796879072504	0.551119511398746	0.487999783446398	0.430431709305824	0.362262101783975	0.316283206690252	NA	0.586022679728604	p.Val255Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.446	-4.437	2.991	1.331	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255S	255	V	S	missense	low	0.27831292899755	0.108300285021705	2	0.0765798659432833	0.12821914980781	0.428406708187291	0.201733063054267	NA	NA	NA	NA	NA	NA	0.354892794940834	0.437753164599971	0.403092569653179	NA	NA	NA	NA	NA	NA	0.472413759546764	p.Val255Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.446	-3.921	2.475	3.366	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255T	255	V	T	missense	low	0.342212606531639	0.0216563253035391	4	0.0108281626517696	0.320989797715429	0.363435415347849	0.325470486387224	0.33784642462435	0.331732892745865	0.373800622369118	NA	NA	NA	NA	0.460796024986557	0.461963930179188	0.463965039362523	0.45675099361325	0.459628119793927	NA	NA	NA	NA	p.Val255Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.446	-3.214	1.768	6.895	6.895	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255V	255	V	V	synonymous	wt-like	1.05748999174721	0.0972987659800069	4	0.0486493829900035	0.962138953216711	1.15284103027772	NA	NA	NA	NA	0.990673061875198	1.19292315887789	0.982930098626811	1.06343364760895	0.822631977570394	NA	NA	NA	NA	0.750183068583481	0.879300984462072	0.816986929060697	0.828277026080092	p.Val255=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V255W	255	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.446	-5.455	4.009	0.662	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V255X	255	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V255Y	255	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val255Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.5	68.9	29.6	0.993	7.2	-178.6	-129.9	125.7	0.606060606060606	-4.9	0	1	22.73	0	0	0	0	6	19.5219224939553	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.446	-4.147	2.701	3.305	NA	39.95	0.002034501	0	0.058149432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256A	256	E	A	missense	possibly_wt-like	0.728174231663044	0.202578017444413	7	0.0765672936066315	0.578105093800343	0.878243369525746	NA	0.806270516188196	0.917680087084971	0.849783749488224	0.59542909390283	0.344863871400623	0.883340256232425	0.699852047344042	0.668371253780328	NA	0.679900662202581	0.744130237875024	0.668371253780328	0.602544495406964	0.461315722177647	0.763348497948304	0.645668873798589	p.Glu256Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.868	-2.926	1.058	9.2	9.2	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E256C	256	E	C	missense	possibly_low	0.634422888033833	0.251294931901552	4	0.125647465950776	0.388158380021589	0.880687396046077	0.961892844887008	0.614765533474917	0.611760910769607	0.349272263003801	NA	NA	NA	NA	0.592855756345942	0.764758744430621	0.59162008811616	0.594091424575724	0.448871169990998	NA	NA	NA	NA	p.Glu256Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.868	-5.459	3.591	0.954	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256D	256	E	D	missense	possibly_low	0.525198520776285	0.281604648146878	3	0.16258451941265	0.206538718283738	0.843858323268832	0.667622605460566	0.200830967069469	0.707141989798821	NA	NA	NA	NA	NA	0.624751874312332	0.624751874312332	0.400803219339446	0.640871309645751	NA	NA	NA	NA	NA	p.Glu256Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.868	-2.571	0.703	28.844	28.844	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.265	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
E256F	256	E	F	missense	low	0.262549594755091	0.235364146025336	4	0.117682073012668	0.0318969700242479	0.493202219485933	NA	0.317826651213798	0.487511662491286	NA	-0.0689575001743886	NA	NA	0.313817565489668	0.453260033054857	NA	0.454736260744216	0.533153074814375	NA	0.354370970355157	NA	NA	0.451783805365499	p.Glu256Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.868	-4.563	2.695	3.584	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256G	256	E	G	missense	low	0.395802347140905	0.0949566473684066	8	0.03357224463647	0.330001956773256	0.461602737508554	0.416776843878877	0.451823099001249	0.326371992947663	0.471563723398565	0.408959507815279	0.189859081727884	0.464714519005223	0.436350009352499	0.509365419153585	0.505405351096315	0.51650636807311	0.454121727106891	0.502502278423523	0.532891051302521	0.384918094531315	0.537879441784789	0.513325487210855	p.Glu256Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.868	-3.822	1.954	3.419	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E256H	256	E	H	missense	low	0.487164389166154	0.111201011286913	5	0.0497306040808516	0.389694196238264	0.584634582094044	NA	0.52645516060094	0.508834515426815	0.550550893188374	0.558595167093977	NA	NA	0.291386209520664	0.543610920540608	NA	0.550910492445885	0.543610920540608	0.537142223470388	0.588785630404052	NA	NA	0.440517700414962	p.Glu256His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.868	-3.42	1.552	10.278	10.278	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256I	256	E	I	missense	wt-like	1.03422870682887	0.129123111707253	3	0.0745492633027848	0.888114835681421	1.18034257797632	1.05686909210414	NA	0.895282742135184	NA	1.1505342862473	NA	NA	NA	0.809897283056193	0.809946212705934	NA	0.733145404894639	NA	0.809897283056193	NA	NA	NA	p.Glu256Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.868	-3.406	1.538	10.039	10.039	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256K	256	E	K	missense	low	0.469713884265199	0.161589582749217	4	0.0807947913746084	0.311359003032539	0.628068765497859	NA	0.304089523894605	0.687756034657816	0.411993409574678	NA	NA	NA	0.475016568933698	0.504561658557978	NA	0.448403676239862	0.631363420212133	0.476377625485899	NA	NA	NA	0.532745691630058	p.Glu256Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.868	-2.09	0.222	9.694	9.694	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.72	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E256L	256	E	L	missense	possibly_low	0.603320260435319	0.159748418463243	8	0.0564795949895927	0.492622288394309	0.71401823247633	0.285775743118422	0.531991057878305	0.598982727696383	0.626292271581779	0.713137095352043	0.574906945557783	0.653962040432422	0.841514201865417	0.58126100208643	0.443078103409732	0.553462447924041	0.587824333223297	0.570358721697925	0.646512886561857	0.574697670949564	0.639806906445943	0.716818415652514	p.Glu256Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.868	-3.303	1.435	11.554	11.554	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256M	256	E	M	missense	possibly_wt-like	0.763507688677088	0.454031318905375	4	0.227015659452687	0.318565172223211	1.20845020513096	1.33203382466294	NA	0.92170303926809	NA	0.344813773298977	NA	0.455480117478344	NA	0.639504579407112	0.94086313127569	NA	0.746103304679089	NA	0.508930192980178	NA	0.532905854135135	NA	p.Glu256Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.868	-3.124	1.256	4.944	4.944	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256N	256	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu256Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.868	-3.465	1.597	7.781	7.781	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256P	256	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu256Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.868	-4.22	2.352	1.678	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256Q	256	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu256Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.868	-2.426	0.558	7.644	7.644	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	1.97	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E256R	256	E	R	missense	low	0.385182568020341	0.11617760254161	7	0.0439110063201153	0.299118577108005	0.471246558932678	0.463763063416446	0.181246430433566	0.301126141953325	0.514398629106296	0.398084465587764	0.478098454273359	NA	0.359560791371634	0.521287592339086	0.527760291062272	0.39177507754941	0.441739837322981	0.521287592339086	0.528828811653573	0.526983409436964	NA	0.474758251684056	p.Glu256Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.868	-2.251	0.383	10.244	10.244	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256S	256	E	S	missense	wt-like	0.901936563460101	0.0933935817824997	5	0.0417668795055711	0.820074983882557	0.983798143037644	0.965138303151126	0.763375216461037	0.852947736142741	0.992080102284656	NA	NA	NA	0.936141459260943	0.730775538607276	0.766302857265627	0.660126650937337	0.712382096962688	0.730775538607276	NA	NA	NA	0.764344771815402	p.Glu256Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.868	-3.702	1.834	3.801	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256T	256	E	T	missense	wt-like	0.928782271684407	0.137510469663933	7	0.0519740721997796	0.826914962042955	1.03064958132586	NA	1.03112210721708	0.920504246764759	1.14882165711571	0.943220476913155	0.852739603578695	0.893712925592848	0.711354884608607	0.745515353944002	NA	0.783553461513783	0.745515353944002	0.799514789049547	0.732457733081781	0.711633800473601	0.768935149132442	0.651446151464309	p.Glu256Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.868	-3.082	1.214	7.75	7.75	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.72	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E256V	256	E	V	missense	wt-like	0.918055636316783	0.0834111402278536	8	0.0294902914408086	0.860255727199208	0.975855545434357	1.01531671761255	0.957044771293064	0.77633847892559	0.954976374862976	0.920365218465022	0.911115962991805	0.993699707025638	0.815587859357613	0.732163171630172	0.790176568619978	0.749405056341707	0.674808898122897	0.71450364176199	0.723920429491359	0.740405913768985	0.822787368988298	0.703796960503744	p.Glu256Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.868	-3.085	1.217	13.762	13.762	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
E256W	256	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu256Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.868	-5.695	3.827	0.75	NA	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E256X	256	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu256Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E256Y	256	E	Y	missense	low	0.430960694335273	0.217547566072386	6	0.0888134219436258	0.256889585982007	0.605031802688539	0.17865571838056	NA	0.808218282658541	NA	0.45459624978928	0.284395487876072	0.495567744834624	0.364330682472563	0.513546010490302	0.392112910939799	NA	0.690444426362472	NA	0.549938100759168	0.431512507330946	0.554496785365791	0.477153920221435	p.Glu256Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	35.5	68.9	26.4	0.99	7.8	-160.6	-129	127	16.3551401869159	-4.5	0	1	19.66	0	0	2	13	7	18.8730394441383	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.868	-3.752	1.884	8.663	8.663	32.51	0.001589127	0	0.045419901	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.07	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257A	257	F	A	missense	low	0.421134717897682	0.107550952075178	8	0.0380250037677138	0.346607080000964	0.495662355794401	0.61781152111306	0.343803685307946	0.459565825081799	0.431100592983466	0.255736180192962	0.378116558796888	0.48993768675785	0.393005692947488	0.488156499366937	0.601052930000854	0.466711236279591	0.519446970044885	0.48475711021794	0.475656342361692	0.477705063663825	0.551464473284064	0.491555888515935	p.Phe257Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.505	-3.061	1.556	8.841	8.841	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F257C	257	F	C	missense	low	0.62959390132331	0.0975554594593865	8	0.0344910634627508	0.561992659147833	0.697195143498787	0.488142872980631	0.650812186303807	0.583915488453219	0.766454667407076	0.621841399723263	0.529195959977332	0.752006936055148	0.644381699686002	0.610323739583293	0.539359631987179	0.608236988421009	0.580434568635899	0.631827156406313	0.612410490745578	0.552167974524729	0.692613239434755	0.617808999468131	p.Phe257Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.505	-2.471	0.966	20.147	20.147	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.43	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F257D	257	F	D	missense	low	0.205878291944731	0.122002381017331	2	0.0862687109382595	0.0367947255130454	0.374961858376416	NA	NA	NA	NA	0.119609581006471	NA	0.29214700288299	NA	0.434871812997214	NA	NA	NA	NA	0.424807908220199	NA	0.444935717774229	NA	p.Phe257Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.505	-3.521	2.016	10.829	10.829	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257E	257	F	E	missense	low	0.285831460077904	0.157558319419856	8	0.0557052780470681	0.176651121356861	0.395011798798947	0.247917295036769	0.206000546404298	0.321130621544242	0.346703121745066	0.633356434689922	0.212901955859327	0.121187328650177	0.197454376693429	0.41412612559154	0.425065942772017	0.403186308411062	0.451551083596072	0.447744469132403	0.616711791891998	0.396275297889431	0.35285796678212	0.393340619890264	p.Phe257Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.505	-4.201	2.696	2.502	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257F	257	F	F	synonymous	wt-like	1.02724964845188	0.275984165029362	3	0.159339531971776	0.714949904473729	1.33954939243003	NA	0.819755922299028	NA	NA	NA	1.34046494483595	NA	0.921528078220662	0.757005229582223	NA	0.686117207466237	NA	NA	NA	0.952020301392192	NA	0.757005229582223	p.Phe257=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	0	2.8	2.8	0	228	228	0	5.2	5.2	0	165	165	0	3.32	3.32	0	NA	NA	NA	NA	NA	NA	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F257G	257	F	G	missense	low	0.325921057528058	0.14444520034131	8	0.0510690903355949	0.22582747974707	0.426014635309047	0.172184441536592	0.269909605998919	0.355337661989388	0.410136250654525	0.331273721935765	0.16281003397336	0.614816893725035	0.290899850410881	0.454300719154333	0.3890340293704	0.432647309322895	0.46832801081158	0.475563165579201	0.503872471608093	0.37158635760305	0.618723589065706	0.440273427497086	p.Phe257Gly	0	0	NA	NA	NA	NA	NA	NA	NA	14.615	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.505	-3.998	2.493	2.392	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257H	257	F	H	missense	possibly_low	0.467073860855628	0.211151998562292	2	0.149307010044489	0.174437498529069	0.759710223182186	NA	NA	NA	NA	0.616380870900117	NA	NA	0.317766850811139	0.532069051457965	NA	NA	NA	NA	0.61037077667132	NA	NA	0.453767326244611	p.Phe257His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.505	-5.098	3.593	0.547	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257I	257	F	I	missense	low	0.475370140760597	0.121736008243257	5	0.0544419979482794	0.368665785535566	0.582074495985628	0.381642821883966	0.473402166782643	0.437032048554528	0.400898925473295	NA	NA	NA	0.683874741108553	0.508395223861382	0.48868940841804	0.526453955154139	0.508395223861382	0.471512122384346	NA	NA	NA	0.63764430278627	p.Phe257Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.505	-2.257	0.752	9.615	9.433	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F257K	257	F	K	missense	possibly_wt-like	0.720518958726135	0.448997484211845	4	0.224498742105922	0.280509509623982	1.16052840782829	NA	0.577023582664488	0.304788648805385	0.643055531841711	1.35720807159296	NA	NA	NA	0.575965979646752	NA	0.574221683972939	0.443536122826892	0.577710275320565	0.887097759860323	NA	NA	NA	p.Phe257Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.505	-4.184	2.679	1.555	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257L	257	F	L	missense	low	0.362052464877019	0.40590326382622	8	0.143508475178636	0.0807810220506311	0.643323907703406	-0.0221699837141144	0.594714366230777	0.531688513937662	0.646547912549098	-0.286254420495276	-0.0253332202163265	0.765536003187148	0.691690547537182	0.567030792323359	0.296564757499663	0.582376837468913	0.554819720384448	0.579241864262269	0.273202350789861	0.278855685808327	0.699899905603991	0.641569776378668	p.Phe257Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.505	-1.967	0.462	20.593	20.593	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	1	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	neutral	neutral	medium	2.575	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
F257M	257	F	M	missense	possibly_low	0.679442867312732	0.164773576946115	7	0.0622785581762837	0.557379136278134	0.80150659834733	NA	0.572784286142909	0.582754747025712	0.689835911763682	0.746782706368596	0.988217396347817	0.700599023813655	0.475125999726751	0.598225883033574	NA	0.572267439621982	0.579865280144645	0.598225883033574	0.659080795009946	0.778407104628748	0.664925277559311	0.532800653033241	p.Phe257Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.505	-3.67	2.165	4.622	4.622	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
F257N	257	F	N	missense	low	0.199879324870213	0.0556752914924886	2	0.0393683761588764	0.12271872546899	0.277039924271436	NA	NA	NA	NA	NA	0.160510948711336	NA	0.239247701029089	0.392392218548719	NA	NA	NA	NA	NA	0.370453201265455	NA	0.414331235831983	p.Phe257Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.505	-4.468	2.963	1.894	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257P	257	F	P	missense	low	0.402178066714754	0.268997569339545	7	0.101671524536184	0.202905540370552	0.601450593058955	0.276462975761287	0.407974063479354	0.436303110828507	0.461823260768729	0.93583823188647	0.145168796220615	NA	0.151676028058314	0.496292700657446	0.438647307375605	0.496292700657446	0.508037714558767	0.498230583525144	0.72970018531155	0.362891473297216	NA	0.370348533237183	p.Phe257Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.505	-4.495	2.99	1	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257Q	257	F	Q	missense	low	0.452245706140996	0.169085260380535	5	0.0756172272408257	0.304038664138197	0.600452748143796	NA	0.166469131853301	0.535802008854524	0.48106159576571	NA	NA	0.468789149825923	0.609106644405524	0.540074011023276	NA	0.384962991599325	0.556837194095225	0.506667584988318	NA	NA	0.540074011023276	0.600092171494156	p.Phe257Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.505	-4.609	3.104	0.936	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257R	257	F	R	missense	low	0.261217396511832	0.153130620131536	8	0.0541398499511552	0.155105240479165	0.367329552544499	0.353252679859585	0.293912216649499	0.3769261723829	0.488350375996501	0.0514796778316464	0.167584029849049	0.0709793962170705	0.287254623308407	0.441077364073566	0.475182045475751	0.443712108879461	0.478916148892218	0.509864090792047	0.399358812192278	0.373939329792271	0.325816306103073	0.438442619267671	p.Phe257Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.505	-4.478	2.973	1.341	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257S	257	F	S	missense	low	0.406465361119899	0.147656624367878	8	0.0522045001888208	0.304146420918896	0.508784301320902	0.381513253185067	0.353032794213332	0.357113515565473	0.369399041403363	0.619730284091339	0.133326339264181	0.517486383146474	0.520121278089964	0.479796731418333	0.488627762673525	0.470965700163141	0.469198982570717	0.457697799677649	0.611621909198573	0.357054649681084	0.56630201914166	0.555399444163792	p.Phe257Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.505	-3.929	2.424	2.571	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F257T	257	F	T	missense	low	0.159241574627282	0.211759994804472	7	0.0800377548407089	0.00237045773604574	0.316112691518517	NA	0.282334952039122	0.240664978125224	0.292626624172345	-0.192782198279803	0.0356003422575773	0.0271465296236741	0.429099794452832	0.412086510647862	NA	0.438375184734334	0.412086510647862	0.424029137778833	0.308117761619092	0.308888174655119	0.30220821376452	0.509684080864914	p.Phe257Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.505	-3.841	2.336	2.923	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257V	257	F	V	missense	possibly_low	0.581856128692373	0.190830563852777	8	0.0674687928789754	0.449619724569188	0.714092532815557	0.58974638812396	0.50475872805079	0.490824194533065	0.681078426799651	0.241064518019267	0.726161109029645	0.536453972173829	0.884761692808774	0.58210901799839	0.587700198725969	0.540908802181657	0.534777714310828	0.594385274505505	0.470175921545747	0.649246717371147	0.576517837270811	0.738539383947453	p.Phe257Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.505	-2.1	0.595	15.766	15.766	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	low	1.885	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
F257W	257	F	W	missense	low	0.450266468070201	0.144987897787184	4	0.0724939488935919	0.308180939141673	0.592351996998728	NA	0.338684357617053	0.48883474280392	0.639188743131699	0.334358028728132	NA	NA	NA	0.519413279839301	NA	0.464351312370116	0.533801982811573	0.576014489172269	0.505024576867029	NA	NA	NA	p.Phe257Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.505	-5.256	3.751	0.406	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F257X	257	F	X	nonsense	low	0.219522765404945	0.377705307706126	7	0.142759187579934	-0.0602801007139233	0.499325631523813	NA	0.0356770819580046	0.260855453482789	0.257446847707158	-0.00602553191422318	-0.0219300689191497	-0.0174119890556	1.02804756457563	0.377878441066943	NA	0.324670057770111	0.42198897900269	0.408600992590724	0.377878441066943	0.280533006142587	0.278209290006978	0.810504434632984	p.Phe257Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F257Y	257	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe257Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33	66.3	25.1	0.8	8.4	-174.5	-105.2	146.8	0	-6.5	0	1	19.93	0	0	0	0	7	21.5189571740826	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.505	-3.953	2.448	1.244	NA	58.56	0.001981085	0	0.056622715	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F258A	258	F	A	missense	low	0.486086570470959	0.0468916740854457	5	0.0209705941667644	0.444984961169695	0.527188179772222	0.474261202241879	NA	NA	NA	0.447275549575768	0.566287941338244	0.459474503196679	0.483133656002222	0.536822482838445	0.532755059007141	NA	NA	NA	0.547203542304751	0.570449599154901	0.535057203891678	0.536822482838445	p.Phe258Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.926	-3.205	1.279	8.913	8.913	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F258C	258	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.926	-5.288	3.362	0.929	NA	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F258D	258	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.926	-4.119	2.193	6.581	NA	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258E	258	F	E	missense	low	0.402545021376472	0.153111461764207	4	0.0765557308821034	0.252498546037409	0.552591496715536	NA	0.228467957635194	0.334661555075285	0.468090996451628	NA	NA	NA	0.578959576343782	0.479583335966408	NA	0.413543406871883	0.458187363264061	0.500979308668754	NA	NA	NA	0.584950865136936	p.Phe258Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.926	-2.993	1.067	21.598	21.598	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.98	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
F258G	258	F	G	missense	low	0.284681249629412	0.236290542974232	6	0.096465210222008	0.0956129118331915	0.473749587425633	0.23386675237949	0.335511238103343	0.0749215086294174	0.123319074665935	0.730141573234563	NA	NA	0.210327350763724	0.409093535301444	0.418381024498449	0.462888557676498	0.330797217917733	0.349779051004891	0.652864702289915	NA	NA	0.399806046104439	p.Phe258Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.926	-3.905	1.979	2.727	NA	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258H	258	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.926	-3.056	1.13	13.002	13.002	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258I	258	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.926	-3.108	1.182	10.646	10.646	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.43	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F258K	258	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.926	-3.003	1.077	10.244	10.244	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F258L	258	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.926	-2.382	0.456	21.99	21.99	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	deleterious	neutral	medium	2.29	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
F258M	258	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.926	-3.893	1.967	4.542	4.542	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258N	258	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.926	-3.595	1.669	9.667	9.667	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258P	258	F	P	missense	low	0.342437621820247	0.166471414287518	7	0.0629202803722824	0.219116138393411	0.465759105247083	NA	0.179043515842468	0.342290586532444	0.446583381417313	0.644641560236185	0.365725490744236	0.182378329693447	0.236400488275637	0.461929040527454	NA	0.390759570996994	0.461929040527454	0.491547110947778	0.620927213172974	0.471597844620946	0.385815035648239	0.412901228758795	p.Phe258Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.926	-4.436	2.51	1.903	NA	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258Q	258	F	Q	missense	low	0.349482496823704	0.250861667521618	6	0.102413846908615	0.148755045364621	0.550209948282788	NA	0.699848093324627	0.3731607073275	NA	-0.067769440294792	0.373415721664592	0.449903849540128	0.268336049380171	0.476228758352609	NA	0.630841716304917	0.477069367283961	NA	0.354814755661664	0.475388149421256	0.529902513066638	0.428940802271653	p.Phe258Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.926	-3.47	1.544	6.158	6.158	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258R	258	F	R	missense	low	0.383477659961499	0.17525669902252	8	0.0619626001635969	0.262033195252394	0.504922124670605	0.655872035775663	0.443190914975932	0.370025729975407	0.516045575935105	0.181608761953729	0.135655464078718	0.289661059348196	0.475761737649244	0.494029443217776	0.619161229173032	0.512527076513289	0.475531809922264	0.522009863409146	0.44796694758549	0.358202611693732	0.443596805011296	0.533119951169552	p.Phe258Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.926	-4.262	2.336	3.963	NA	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258S	258	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.926	-2.621	0.695	8.95	8.95	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.635	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F258T	258	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.926	-2.96	1.034	9.885	9.885	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.635	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F258V	258	F	V	missense	low	0.398781015318756	0.176000443101428	8	0.0622255534044284	0.276821171728002	0.520740858909509	0.482680094726695	0.433173263648825	0.518517634679463	0.590563338089306	0.116586517597282	0.150550792834896	0.523855480915075	0.374321000058503	0.522334839105183	0.53676057036622	0.507909107844147	0.54836003022115	0.554689742849134	0.423678679681572	0.365544112445979	0.569732373118487	0.482171537817443	p.Phe258Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.926	-2.888	0.962	9.553	9.553	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.635	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F258W	258	F	W	missense	wt-like	1.05479126330025	0.202289060388639	5	0.0904664180267111	0.877480342157556	1.23210218444295	1.2896211716062	1.00110900995136	0.81793688411135	1.23757197798634	NA	NA	NA	0.927717272846024	0.769717928781478	0.920684186848754	0.769717928781478	0.695210938375453	0.83843637904994	NA	NA	NA	0.760113740556993	p.Phe258Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.926	-3.465	1.539	15.401	15.401	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.98	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F258X	258	F	X	nonsense	low	0.0236315852346748	0.0314427280040281	5	0.0140616154430086	-0.00392867459807434	0.051191845067424	0.0064571321375524	0.0467908117870694	0.0492720644529124	0.039169847926608	NA	NA	NA	-0.0235319301307682	0.312875277927019	0.310184867024559	0.329793300182138	0.318217384863848	0.312875277927019	NA	NA	NA	0.282350676671802	p.Phe258Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F258Y	258	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe258Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	31.8	65.7	21.6	0.912	24.2	-122.9	-133.9	162	8.33333333333333	-5.5	0	1	30.35	0	0	0	0	8	22.5170450516936	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.926	-2.034	0.108	16.224	16.224	32.51	0.002573867	0.006896552	0.073565399	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.7	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
H259A	259	H	A	missense	possibly_wt-like	0.728952313010639	0.113471461057806	5	0.0507459800862948	0.629492019681314	0.828412606339963	0.806082040941434	NA	NA	NA	0.842462843188675	0.705452002872927	0.550121358487578	0.740643319562578	0.666156211011505	0.690627622528683	NA	NA	NA	0.694820945464154	0.639039764512531	0.583879001237447	0.666156211011505	p.His259Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-2.01	-2.756	0.746	10.135	10.135	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H259C	259	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His259Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-2.01	-3.077	1.067	19.668	19.668	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259D	259	H	D	missense	wt-like	1.07886562862613	0.0489450956708354	3	0.0282584641610688	1.02348005661202	1.13425120064024	NA	NA	NA	NA	1.0784588523058	NA	1.03012518888127	1.12801284469131	0.842405892848509	NA	NA	NA	NA	0.78297438203688	NA	0.842405892848509	0.860711802335105	p.His259Asp	1	0	NA	NA	NA	NA	NA	NA	NA	7.906	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-2.01	-2.885	0.875	12.305	12.305	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.785714285714286
H259E	259	H	E	missense	wt-like	0.908526324037022	0.235670830031498	8	0.0833222210215673	0.745217771722864	1.07183487635118	0.718941033921139	1.06643128538913	0.910818133699608	1.04155662857558	1.12919525865963	1.12922583347238	0.815304755981877	0.456737662596833	0.746619160703227	0.649167977558648	0.799830398413201	0.740764775940746	0.752473545465709	0.80192634904756	0.847906312344704	0.726705027031517	0.523565146438911	p.His259Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-2.01	-2.972	0.962	8.772	8.772	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
H259F	259	H	F	missense	low	0.440107458904714	0.194079040913243	8	0.0686173029579677	0.305620016390824	0.574594901418605	0.814701258931063	0.460555368032939	0.387648918744932	0.619099666042	0.353363020167569	0.191187169615251	0.32097308231097	0.373331187392989	0.498149403165866	0.69472844405908	0.520531797136483	0.484175146248468	0.567204393453164	0.512123660083264	0.385572672780896	0.46046125369701	0.481674406329429	p.His259Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-2.01	-4.436	2.426	3.91	NA	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259G	259	H	G	missense	low	0.475692398517546	0.0805888628485363	8	0.0284924657041563	0.419848191906657	0.531536605128435	0.550802268566702	0.436884659749993	0.509974783517638	0.599095646246072	0.369353544191877	0.448790464327202	0.381939049813183	0.508698771727698	0.531133446761646	0.569171501092965	0.509619998985625	0.544170167833474	0.558431599741334	0.518096725689818	0.512538301594192	0.493297120984737	0.549662512537666	p.His259Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-2.01	-3.216	1.206	16.574	16.574	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
H259I	259	H	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His259Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-2.01	-4.243	2.233	4.226	NA	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259K	259	H	K	missense	low	0.401176043510768	0.204823588046859	8	0.0724160740274468	0.259243146515186	0.54310894050635	0.64768361579849	0.511710295056701	0.463161865550639	0.628625589502322	0.0353713779569778	0.344156334821448	0.250394650795684	0.328304618603882	0.491088826834045	0.615265371221333	0.544113357579575	0.521210656947483	0.571382001868104	0.393341752850434	0.460966996720607	0.422448176802465	0.459059899643271	p.His259Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-2.01	-3.147	1.137	10.244	10.244	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H259L	259	H	L	missense	low	0.547962092170276	0.0725752761324898	8	0.0256592349498849	0.49767091579765	0.598253268542902	0.658146251866317	0.632979638263434	0.512015544845234	0.5961209779172	0.534883796349264	0.458046873451697	0.48619624466995	0.505307409999113	0.553288205828388	0.620243247787778	0.600016483888316	0.545171064251631	0.557127054361128	0.579928536486166	0.51710053285897	0.549449357295647	0.547959207699017	p.His259Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-2.01	-3.169	1.159	13.791	13.791	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H259M	259	H	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His259Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-2.01	-3.941	1.931	4.582	4.582	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259N	259	H	N	missense	wt-like	1.26657560297571	0.21945153420677	2	0.155175667979399	0.962436882459141	1.57071432349227	1.42175127095511	NA	NA	NA	NA	NA	NA	1.11139993499631	0.917958293136897	0.983548585553548	NA	NA	NA	NA	NA	NA	0.852368000720247	p.His259Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-2.01	-2.241	0.231	27.585	27.585	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.525	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
H259P	259	H	P	missense	low	0.449504173434771	0.095914709944869	8	0.0339109709087788	0.383039891772779	0.515968455096763	0.408444288701256	0.415596304021501	0.582308885090116	0.492834356645336	0.388470352603832	0.563405650819018	0.290373639709386	0.45459990988772	0.51716100585541	0.501440917000701	0.499806425268429	0.57964660606047	0.511830547416334	0.525237576775057	0.569028996873375	0.443980596085735	0.522491464294486	p.His259Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-2.01	-4.26	2.25	2.117	NA	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	1	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H259Q	259	H	Q	missense	possibly_low	0.354330386747841	0.565052224908962	4	0.282526112454481	-0.199410618355055	0.908071391850737	0.93613138149755	NA	NA	NA	-0.331287601313437	0.138005176043204	NA	0.674472590764048	0.496141405797399	0.752502045058456	NA	NA	NA	0.256380754256203	0.359360720550355	NA	0.632922091044444	p.His259Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-2.01	-3.039	1.029	8.387	8.387	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	medium	2.91	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.714285714285714
H259R	259	H	R	missense	low	0.428158948993368	0.229589754832309	6	0.0937296249183076	0.244452259869037	0.611865638117699	NA	0.439739214259821	0.326334501605303	0.575806110537774	0.0517717561783715	0.726777777720642	NA	0.448524333658295	0.515187959256036	NA	0.510935900573763	0.454103339385715	0.548217937962474	0.399467914503409	0.649550656527707	NA	0.51944001793831	p.His259Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-2.01	-2.847	0.837	13.574	13.574	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H259S	259	H	S	missense	possibly_wt-like	0.732249523304832	0.108854541065555	8	0.0384858920752018	0.656818560924541	0.807680485685123	0.796408170421039	0.795294997944296	0.717110690964074	0.831681506586572	0.852212479735522	0.586154278344522	0.562680133232638	0.716453929209996	0.657219811982125	0.686025022088591	0.674841133005274	0.645760483678529	0.660432487256513	0.698462803519952	0.580241174115304	0.590643074337907	0.654007136707737	p.His259Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-2.01	-2.287	0.277	15.989	15.989	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.935	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
H259T	259	H	T	missense	wt-like	0.842973977692344	0.161449109181644	7	0.0610220274696493	0.723373001588218	0.962574953796471	1.11951765011167	0.95437911275326	0.859081010930381	0.861799771284011	0.66774733971608	NA	0.666598111448547	0.771694847602464	0.681751780635351	0.839752925546329	0.748176232616714	0.715390176684461	0.673640898658042	0.629558095845373	NA	0.646612610807294	0.681751780635351	p.His259Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-2.01	-2.886	0.876	8.909	8.909	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H259V	259	H	V	missense	low	0.572722364555279	0.0863706929340008	8	0.0305366513347065	0.512871627730797	0.63257310137976	0.636358188858198	0.409352209756612	0.522725203778084	0.582630324596931	0.705943177442242	0.548543631689233	0.581951846978415	0.594274333342516	0.577173292804371	0.609876999017082	0.496928002897667	0.550423642846013	0.551210707555641	0.64382568609375	0.561703913526292	0.601022692031015	0.59264267208245	p.His259Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-2.01	-3.94	1.93	3.519	NA	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259W	259	H	W	missense	possibly_wt-like	0.840136776179871	0.168809433025283	6	0.0689161624467458	0.705063579831538	0.975209972528205	NA	0.803473939853382	0.957903349579613	1.01023773785332	0.975393755557522	0.595113601527258	0.698698272708133	NA	0.708675042623979	NA	0.678611487577378	0.763857836008659	0.73873859767058	0.744475669694028	0.58465697983281	0.663901545572352	NA	p.His259Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-2.01	-5.618	3.608	0.819	NA	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H259X	259	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His259Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H259Y	259	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His259Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	63.5	19.9	0.939	20.2	-141	-109	122.3	0	-6.7	0	1	34.07	2	47	0	0	7	25.4372348705593	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-2.01	-3.216	1.206	9.451	9.451	87.1	0.002245523	0	0.064180773	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.91	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K260A	260	K	A	missense	wt-like	1.17661077845249	0.120534306968053	8	0.0426153129113656	1.09308629995631	1.26013525694867	1.01157310910422	1.01305017481894	1.22989076604143	1.24988834386347	1.35345090393143	1.24899238174607	1.12238351681238	1.18365703130199	0.887176651277892	0.78839544759591	0.775222604820893	0.897254734136435	0.843837740287419	0.885694315614031	0.906935973162399	0.892095618711119	0.888658986941753	p.Lys260Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.857	-2.579	0.722	10.781	10.781	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K260C	260	K	C	missense	possibly_wt-like	1.04552816391689	0.459913916439758	4	0.229956958219879	0.594820807811541	1.49623552002223	0.378501678041641	1.32847682614706	1.10373833073302	1.37139582074583	NA	NA	NA	NA	0.866253996576094	0.487194925935501	0.920628982591726	0.835382961609893	0.897125031542295	NA	NA	NA	NA	p.Lys260Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.857	-3.803	1.946	14.991	14.991	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260D	260	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.857	-3.915	2.058	6.581	NA	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260E	260	K	E	missense	possibly_wt-like	0.736391259356036	0.52486375900334	4	0.26243187950167	0.222034227137607	1.25074829157446	NA	1.03707791177073	1.04730595885075	0.906162542422468	-0.0449813756198023	NA	NA	NA	0.739697623746228	NA	0.786298987179451	0.807705565864845	0.693096260313006	0.363326959836036	NA	NA	NA	p.Lys260Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.857	-2.612	0.755	21.598	21.598	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	T	D	D	D	0.714285714285714
K260F	260	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.857	-3.815	1.958	10.234	10.234	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260G	260	K	G	missense	wt-like	1.02601563160508	0.0715792021903748	8	0.0253070696303685	0.97641468657531	1.07561657663485	0.932214527998053	1.08309355959062	0.968601775005366	0.977757797284202	1.11383740970027	1.01968920443203	0.99098140278659	1.12194937604351	0.795054155424107	0.750638498135582	0.807511426401363	0.769104905101825	0.724494469675696	0.796189611510357	0.793918699337857	0.821323308285287	0.857666436988278	p.Lys260Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.857	-2.762	0.905	14.802	14.802	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260H	260	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.857	-3.689	1.832	10.015	10.015	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260I	260	K	I	missense	wt-like	1.14373773637988	0.108590842866589	4	0.0542954214332945	1.0373206658452	1.25015480691456	NA	1.00356766565259	1.19261008866272	1.25710705492385	NA	NA	NA	1.12166613628036	0.852263848758026	NA	0.770851327681653	0.878970334118539	0.847003517148471	NA	NA	NA	0.857524180367581	p.Lys260Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.857	-3.666	1.809	10.646	10.646	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K260L	260	K	L	missense	wt-like	1.13086956201517	0.104960400034861	8	0.0371091053103514	1.05813705210838	1.20360207192196	0.975157128829459	0.99018791117274	1.10996619849183	1.20648691404609	1.20118680746592	1.27805648503367	1.14638044252738	1.13953460855426	0.8336276752415	0.771069579269926	0.76468348604181	0.8384374346873	0.824803976350436	0.828817915795701	0.921260875931714	0.905020204350845	0.86649858584809	p.Lys260Leu	0	0	NA	NA	NA	NA	NA	NA	NA	-2.066	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.857	-3.079	1.222	11.368	11.368	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260M	260	K	M	missense	possibly_low	0.623668869478752	0.434614915818561	4	0.21730745790928	0.197754078404609	1.04958366055289	0.770023131641247	NA	NA	0.194552610810455	0.36434245058334	NA	NA	1.16575728487997	0.594848266428624	0.673471640187966	NA	NA	0.381018628066664	0.516224892669281	NA	NA	0.879668874081114	p.Lys260Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.857	-4.962	3.105	1.509	NA	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260N	260	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.857	-3.041	1.184	12.575	12.575	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K260P	260	K	P	missense	possibly_low	0.670922600318992	0.318231555009868	7	0.120280221984212	0.435177697177454	0.906667503460529	NA	0.656954203114778	0.648435142601594	0.931278631741758	0.303027253391281	1.1601724714321	0.269353069717905	0.727237430233526	0.612078391881959	NA	0.611068354803432	0.612078391881959	0.704110959993063	0.493321347110035	0.863159065041855	0.43265905597358	0.659423129144092	p.Lys260Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.857	-3.098	1.241	14.609	14.609	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260Q	260	K	Q	missense	wt-like	0.961522954004836	0.249121551774035	6	0.101703447629454	0.76218785954755	1.16085804846212	1.12910654208424	0.475338675826618	0.933486917821588	NA	1.10024518029615	NA	1.01963136865522	1.1113290393452	0.813933195137412	0.844315095188763	0.527346653232818	0.751882736931507	NA	0.791112399666225	NA	0.8367539906086	0.852332393517228	p.Lys260Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.857	-2.969	1.112	6.742	6.742	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K260R	260	K	R	missense	wt-like	0.991134131752122	0.128712364426894	3	0.0743121182499004	0.845485056367435	1.13678320713681	0.878588570438242	NA	0.963341490101377	NA	NA	NA	NA	1.13147233471675	0.766524985418081	0.725124526727264	NA	0.766524985418081	NA	NA	NA	NA	0.862449324478474	p.Lys260Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.857	-2.454	0.597	29.965	29.965	87.1	0.002189986	0	0.062593452	4.062e-06	1	246202	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Jul 20, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	1.985	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K260S	260	K	S	missense	possibly_wt-like	0.76685789310198	0.325033728492614	8	0.114916776765737	0.541625149421706	0.992090636782254	0.0822387961772973	0.863951313715802	0.94285618050662	0.978650119628038	0.635473356103349	0.586826340341499	0.971171300215977	1.07369573812726	0.715688169067631	0.346240003334776	0.706490539120423	0.756477914885642	0.724885799014839	0.617502542118013	0.58057241511959	0.810653717928317	0.833431141103316	p.Lys260Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.857	-2.313	0.456	8.077	8.077	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.11	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260T	260	K	T	missense	wt-like	0.941980284003422	0.274374830769955	8	0.0970061517121734	0.751851720368734	1.13210884763811	1.18258864129768	1.1486104220956	0.997423101295645	1.19144554236048	0.737108304171788	0.435217464661386	0.746404786193575	1.09704400995122	0.800723977582249	0.869760622173834	0.837713597396257	0.783240395548647	0.818207559615851	0.655467039829823	0.505848540737756	0.689595958533342	0.845157765260409	p.Lys260Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.857	-3.094	1.237	7.078	7.078	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K260V	260	K	V	missense	wt-like	1.01804113695623	0.0983111769726911	8	0.0347582499519103	0.949916218884848	1.08616605502762	1.00667449022139	0.948877121005991	0.863094335844247	1.01099615140616	1.05891993239397	0.976779274394091	1.08559841447703	1.19338937590699	0.77422271151601	0.786064799756616	0.745639907017318	0.717358521770617	0.739071201103049	0.775675856338964	0.772769566693055	0.872283405636582	0.893547038109335	p.Lys260Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.857	-3.454	1.597	8.284	8.284	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260W	260	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.857	-5.699	3.842	1.112	NA	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K260X	260	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys260Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	2	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K260Y	260	K	Y	missense	wt-like	1.25430402532967	0.281779036393306	3	0.162685202513669	0.93544688758527	1.57316116307406	0.987693025332736	NA	1.22609062129143	1.54912842936483	NA	NA	NA	NA	0.895390943786566	0.777033864469039	NA	0.895390943786566	0.975069940974824	NA	NA	NA	NA	p.Lys260Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	-1.737	30.5	61.2	17.2	0.742	20.8	-156.2	-84.2	107.3	27.8260869565217	-3.7	0	0	50.88	0	0	0	0	5	28.0139393491883	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.857	-3.56	1.703	12.838	12.838	87.1	0.002189986	0	0.062593452	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q261A	261	Q	A	missense	wt-like	1.18225496211113	0.420984672211098	4	0.210492336105549	0.769697564322557	1.59481235989971	NA	NA	0.992418426570536	1.37519578112449	1.65945922740996	NA	NA	0.70194641333955	0.839788675264707	NA	NA	0.780785840506532	0.898791510022882	1	NA	NA	0.646720765050408	p.Gln261Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.483	-2.869	0.386	10.35	10.35	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q261C	261	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.483	-3.868	1.385	14.271	14.271	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q261D	261	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.483	-2.559	0.076	14.766	14.766	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q261E	261	Q	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.483	-2.953	0.47	11.868	11.868	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
Q261F	261	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.483	-3.647	1.164	28.024	28.024	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.56	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Q261G	261	Q	G	missense	wt-like	0.920866975113668	0.150443934390951	5	0.0672805728201372	0.788999475526975	1.05273447470036	NA	0.671673243855851	NA	NA	0.920195241483136	1.04508916237321	1.03424192362019	0.93313530423596	0.762834936295168	NA	0.617853584870103	NA	NA	0.7238569366588	0.806437644933794	0.844623138979163	0.762834936295168	p.Gln261Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.483	-2.67	0.187	15.435	15.435	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q261H	261	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.483	-3.357	0.874	14.759	14.759	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Q261I	261	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.483	-3.543	1.06	11.521	11.521	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Q261K	261	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.483	-2.449	-0.034	11.207	11.207	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
Q261L	261	Q	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.483	-3.885	1.402	8.303	NA	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
Q261M	261	Q	M	missense	low	0.441974501098262	0.124392073139974	2	0.0879584784431289	0.269579051214787	0.614369950981738	NA	NA	NA	NA	0.529932979541391	NA	0.354016022655133	NA	0.52816859108939	NA	NA	NA	NA	0.578079219130807	NA	0.478257963047974	NA	p.Gln261Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.483	-5.051	2.568	1.825	NA	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q261N	261	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.483	-2.489	0.006	12.732	12.732	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.59	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q261P	261	Q	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.483	-2.774	0.291	27.131	27.131	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.665	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
Q261R	261	Q	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.483	-2.776	0.293	13.659	13.659	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.5
Q261S	261	Q	S	missense	wt-like	0.803674954019493	0.108995101943426	6	0.044497064037338	0.716462311088538	0.890887596950448	0.993464777502554	0.779571162980937	0.703727888018419	0.749248765552461	0.728079749155975	NA	NA	0.867957380906612	0.659843621357519	0.779779928624115	0.667592709712374	0.639196855020891	0.624281481630123	0.652094533002664	NA	NA	0.730099450945948	p.Gln261Ser	0	0	NA	NA	NA	NA	NA	NA	NA	1.958	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.483	-2.297	-0.186	10.587	10.587	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q261T	261	Q	T	missense	wt-like	1.01209296108401	0.171203127965943	2	0.121058892745067	0.774821891295378	1.24936403087263	NA	NA	NA	NA	1.13315185382907	NA	0.89103406833894	NA	0.785448310663463	NA	NA	NA	NA	0.803404287011929	NA	0.767492334314997	NA	p.Gln261Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.483	-3.019	0.536	13.424	13.424	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q261V	261	Q	V	missense	wt-like	1.08492424449094	0.13592206674153	5	0.060786196175265	0.965785489230232	1.20406299975164	NA	0.866760315701552	NA	NA	1.21033739863417	1.1683532152844	1.04732740942753	1.13184288340704	0.851670895177729	NA	0.707785441761589	NA	NA	0.832236007742133	0.867191130270405	0.851670895177729	0.862635431838184	p.Gln261Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.483	-3.53	1.047	8.752	8.752	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.56	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q261W	261	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.483	-5.755	3.272	1.302	NA	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.56	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Q261X	261	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	1	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q261Y	261	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln261Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	61.2	14.5	0.741	24.4	-101.5	-91.7	131.2	21.4953271028037	-2.4	0	0	68.51	1	2	0	0	4	29.4072419288175	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.483	-3.839	1.356	9.057	9.057	39.95	0.002335713	0	0.066758566	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.56	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N262A	262	N	A	missense	wt-like	1.12873797555387	0.0889876554320036	7	0.0336341722896839	1.06281620921628	1.19465974189147	NA	1.10751492465295	1.12366489268334	1.04399353998777	1.13190200579342	1.31838368513887	1.10423079279852	1.07147598782223	0.832316275825668	NA	0.818769264694295	0.845155992984296	0.753542256721306	0.802937421491836	0.94113705152707	0.882318681494331	0.832316275825668	p.Asn262Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.235	-2.951	0.716	9.651	7.835	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.595	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N262C	262	N	C	missense	wt-like	0.985298393653502	0.0226732717103544	4	0.0113366358551772	0.963078995671509	1.00751779163549	NA	NA	NA	NA	1.00615637973058	0.996571880486548	0.984462051242541	0.954003263154337	0.777920314907194	NA	NA	NA	NA	0.75596667349954	0.782524801699628	0.817812028617746	0.773315828114761	p.Asn262Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.235	-3.825	1.59	13.791	13.791	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.595	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N262D	262	N	D	missense	wt-like	1.22105672264557	0.186113531877365	8	0.0658010702305316	1.09208899484954	1.3500244504416	0.811317106741595	1.24543018724708	1.2097051936995	1.26633042468935	1.42612716716628	1.3924910493703	1.21357142482038	1.20348122743009	0.892985160702847	0.693118343911084	0.88234587969714	0.8873546704777	0.851048440174248	0.912841649102355	0.977662547483404	0.941208823475523	0.898615650927994	p.Asn262Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.235	-2.753	0.518	28.844	28.844	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.7	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
N262E	262	N	E	missense	possibly_wt-like	0.845236479559089	0.334525322858596	8	0.118272562135966	0.61342651741332	1.07704644170486	0.42571014555349	0.440754617201213	0.719704379018887	0.599202329376027	1.21260934787437	1.07315331075148	1.13174960521244	1.15900810148481	0.733651130804315	0.509655606268985	0.511403984240961	0.64703256437154	0.558478385792396	0.833084666725781	0.820269697237089	0.897140132040595	0.876279109834792	p.Asn262Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.235	-3.262	1.027	13.047	13.047	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.245	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N262F	262	N	F	missense	wt-like	0.812229771051981	0.010853933078856	2	0.00767488968260405	0.797187263688759	0.827272278415203	NA	NA	NA	NA	0.819904660734585	NA	0.804554881369377	NA	0.703654913293017	NA	NA	NA	NA	0.686394610995185	NA	0.720915215590848	NA	p.Asn262Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.235	-3.56	1.325	10.999	10.999	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N262G	262	N	G	missense	wt-like	1.02616459247071	0.114560252152913	8	0.0405031655758829	0.946779846682112	1.1055493382593	1.19462585229662	0.984229292681467	0.964949903071295	1.06474156447996	0.799743104171885	1.0721398321642	1.07404036700714	1.05484682389307	0.793542008419583	0.875487644519688	0.761936663198254	0.767313835519628	0.76264133483935	0.678863506955306	0.819770181319538	0.866058317634613	0.823964310553284	p.Asn262Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.235	-2.586	0.351	24.544	24.544	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.555	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N262H	262	N	H	missense	wt-like	1.02304197426818	0.191984134373033	2	0.135753283295401	0.75697042822613	1.28911352031023	NA	NA	NA	NA	0.887288690972777	NA	NA	1.15879525756358	0.793868652327796	NA	NA	NA	NA	0.711565095266676	NA	NA	0.876172209388917	p.Asn262His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.235	-3.336	1.101	13.177	13.177	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.595	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N262I	262	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn262Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.235	-3.257	1.022	9.972	9.972	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.785714285714286
N262K	262	N	K	missense	wt-like	1.16596249069545	0.100468414946361	3	0.0580054664143364	1.0522738656169	1.27965111577399	NA	1.10928154742237	1.28196341752182	1.10664250714214	NA	NA	NA	NA	0.819583648059516	NA	0.819583648059516	0.922793894275294	0.781017057821855	NA	NA	NA	NA	p.Asn262Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.235	-2.687	0.452	14.232	14.232	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.045	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
N262L	262	N	L	missense	wt-like	0.8926359080276	0.0940734467287401	8	0.0332599860557418	0.827447533232041	0.957824282823158	0.733915677292275	0.777613789339731	0.96948340411021	0.986769605268487	0.971327715666108	0.873468424631114	0.88910180132217	0.9394068465907	0.735701730971116	0.656292561252931	0.666690393405513	0.769537302267161	0.728446611956262	0.742956849985971	0.721850470265894	0.766451628066469	0.765984806257013	p.Asn262Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.235	-2.52	0.285	11.368	11.368	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N262M	262	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn262Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.235	-4.021	1.786	4.622	4.622	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.595	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N262N	262	N	N	synonymous	wt-like	1.06025621060195	0.215830369380998	8	0.0763075588876504	0.910696143433981	1.20981627776991	1.29422016154328	1.03672246721483	1.03072140677912	0.742349679745737	0.825313149412261	1.39050949770217	1.12420217020636	1.0380111522118	0.807540129314125	0.922872278271288	0.786135133221157	0.799571631464594	0.621255876916667	0.688414886106554	0.976685894782389	0.893075133413069	0.815508627163656	p.Asn262=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	0	-3.5	-3.5	0	187	187	0	11.6	11.6	0	132	132	0	5.47	5.47	0	NA	NA	NA	NA	NA	NA	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
N262P	262	N	P	missense	possibly_wt-like	0.910132688098233	0.353529705593029	8	0.124991626087857	0.665153602596935	1.15511177359953	0.3824566551491	0.903272897303387	0.673953534482124	0.502631133492931	1.31857947431164	1.08523425716816	1.21867280677168	1.19626074610684	0.775420596592208	0.489076611175857	0.72461712738939	0.624593950014588	0.516126939001704	0.872668517547832	0.826224065795026	0.943956394089091	0.894989178213037	p.Asn262Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.235	-3.148	0.913	20.01	20.01	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.495	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N262Q	262	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn262Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.235	-4.298	2.063	2.922	NA	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.595	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N262R	262	N	R	missense	wt-like	0.989797504928083	0.0947990756648158	8	0.0335165346264039	0.924106304173742	1.05548870568242	1.11384051946236	1.11871155471446	1.01923990367188	0.917573498438041	0.922515329113637	0.952949121328336	1.01835916914233	0.855190943553616	0.777482417521581	0.83705188008889	0.823930722718305	0.793940499994344	0.698100552660276	0.724723577152187	0.761024335048817	0.836068792356526	0.723687532591032	p.Asn262Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.235	-3.143	0.908	17.586	17.586	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.595	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N262S	262	N	S	missense	wt-like	0.832972362910055	0.055581850310487	3	0.0320901962388172	0.770076734025151	0.895867991794959	NA	NA	NA	NA	0.808502565335904	0.79382376396734	NA	0.896590759426922	0.682595792121715	NA	NA	NA	NA	0.68213549704964	0.682595792121715	NA	0.744480509672135	p.Asn262Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.235	-2.281	0.046	19.427	19.427	39.95	0.003011067	0.007092199	0.086061299	4.062e-06	1	246192	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.555	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N262T	262	N	T	missense	possibly_wt-like	0.763468409039009	0.358541983720544	6	0.146374151913434	0.476580343021083	1.05035647505693	1.05383513392247	NA	0.680660117891748	0.198765653645007	0.921003382877108	0.556708810202684	NA	1.16983735569504	0.676021009200604	0.808502726643893	NA	0.627883210361692	0.382866264494926	0.724158808039515	0.565728307024412	NA	0.881718081720268	p.Asn262Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.235	-2.992	0.757	9.885	9.885	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.595	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
N262V	262	N	V	missense	possibly_wt-like	0.792611880631666	0.333852454297145	8	0.118034667174642	0.561268184042196	1.02395557722114	1.04160009988702	1.19247910619488	0.975977751702241	1.00077420381579	0.290533402900714	0.64642284379031	0.340597628802699	0.852510007959677	0.728464694065643	0.802681584742379	0.85793632247542	0.772722471034931	0.734588350233159	0.488654421339173	0.609945904088017	0.471030904775882	0.722341037898127	p.Asn262Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.235	-3.011	0.776	8.217	8.217	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N262W	262	N	W	missense	low	0.262597861182025	0.257957813449822	2	0.182403719150424	-0.0949068589989646	0.620102581363015	NA	0.445001580332449	NA	NA	NA	0.0801941420316012	NA	NA	0.422114501738136	NA	0.513361762769944	NA	NA	NA	0.330867240706328	NA	NA	p.Asn262Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.235	-5.684	3.449	1.071	NA	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.595	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N262X	262	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn262Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N262Y	262	N	Y	missense	possibly_wt-like	0.715867288984455	0.241881029936338	3	0.139650077745609	0.442158166164843	0.989576411804067	NA	NA	NA	NA	0.832976956110722	0.43772095503425	0.876903955808392	NA	0.691277607812001	NA	NA	NA	NA	0.691277607812001	0.507082442772177	0.759881949065277	NA	p.Asn262Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.7	58.2	12.2	0.105	97	-0.4	-48.9	136.7	47.0588235294118	-0.8	0	0	87.31	0	0	0	0	4	33.0044051281037	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.235	-3.227	0.992	12.365	12.365	39.95	0.003011067	0.007092199	0.086061299	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.245	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K263A	263	K	A	missense	wt-like	0.984114610141578	0.308945412947108	8	0.109228698255689	0.770030295482235	1.19819892480092	0.942541568113126	1.03529676361331	1.14537462190344	1.20585382920148	0.285651048392896	1.23489571485879	0.876835523620055	1.14646781142953	0.805002121935468	0.755551861331655	0.78547790785482	0.855803583136916	0.824526336016117	0.48683067724265	0.899988111033862	0.759845091940778	0.869980773520743	p.Lys263Ala	0	0	NA	NA	NA	NA	NA	NA	NA	2.006	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-2.265	-2.891	0.626	8.841	8.841	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.93	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K263C	263	K	C	missense	wt-like	0.990430290650827	0.0957005215467322	4	0.0478502607733661	0.89664550288418	1.08421507841747	0.991370371823509	1.08399102529374	1.02760758127411	0.858752184211949	NA	NA	NA	NA	0.788413953829719	0.778783459581059	0.80792514298655	0.798044448078379	0.672304374650628	NA	NA	NA	NA	p.Lys263Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-2.265	-5.407	3.142	1.357	NA	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K263D	263	K	D	missense	wt-like	1.04676508707527	0.242223443521219	8	0.0856389197381053	0.878915888713665	1.21461428543687	0.515715265238009	1.24920436034115	1.08083851417662	1.22217734716841	1.22483818058649	1.0219557496826	1.13663272905633	0.922758550352532	0.827918365085612	0.552477928792025	0.884085709975837	0.824151690192796	0.831685039978428	0.837652598331402	0.795035817592478	0.899770150279569	0.757623231819605	p.Lys263Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-2.265	-2.819	0.554	14.373	14.373	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K263E	263	K	E	missense	wt-like	1.15933834724724	0.14690055924177	8	0.0519371907999759	1.0575433238211	1.26113337067338	0.893792643424595	1.16275202244827	1.2096458229054	1.31373479214154	1.34022549583752	1.0764697737656	1.22196472681913	1.05612150063589	0.858035167871134	0.732358267645198	0.84423263716194	0.887325551925538	0.871837698580329	0.880754125405236	0.821904291284089	0.945729400476561	0.824604514470623	p.Lys263Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-2.265	-3.152	0.887	10.836	10.836	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.93	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K263F	263	K	F	missense	wt-like	1.11282242800673	0.126656510279332	3	0.0731251703043907	0.969499727846763	1.25614512816669	NA	NA	NA	NA	1.24452774128032	NA	1.1020347733019	0.991904769437963	0.845007394059775	NA	NA	NA	NA	0.845007394059775	NA	0.881135919902797	0.792351786001782	p.Lys263Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-2.265	-3.629	1.364	14.156	14.156	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K263G	263	K	G	missense	wt-like	0.896354127853427	0.137278331752458	8	0.0485352196460696	0.801226845365389	0.991481410341464	0.997856257700585	0.918230487239075	0.898560653571077	0.981717298698362	0.587491629142527	0.949522296739633	0.833227552413124	1.00422684732303	0.735555595700577	0.781869291785375	0.7315123246201	0.734753064629688	0.726230915123286	0.599579552063586	0.759335346795681	0.736358126771467	0.798540525677337	p.Lys263Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-2.265	-2.53	0.265	15.814	15.814	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K263H	263	K	H	missense	possibly_wt-like	0.908960904885556	0.414839488034347	6	0.169357511806926	0.577026281232664	1.24089552853845	1.03283507143269	1.15762512358818	1.15432179134528	1.11883019399452	0.0849346837368261	NA	NA	0.905218565215844	0.792436688345691	0.798511390016674	0.841869223070886	0.860191744420592	0.786361986674707	0.411855522421131	NA	NA	0.748813808365498	p.Lys263His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-2.265	-4.057	1.792	7.994	7.994	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K263I	263	K	I	missense	possibly_wt-like	1.003535440656	0.24049743254427	2	0.170057365410008	0.670229129146613	1.33684175216538	NA	NA	1.173592806066	0.833478075245988	NA	NA	NA	NA	0.765431818126523	NA	NA	0.869643261042061	0.661220375210984	NA	NA	NA	NA	p.Lys263Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-2.265	-3.19	0.925	11.937	8.018	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.93	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K263L	263	K	L	missense	wt-like	0.886090582081098	0.194781702534195	8	0.068865731356495	0.751116228853357	1.02106493530884	0.573555095309323	0.826118275700618	0.789834777337455	0.740936233143974	1.04460203941848	1.18137461657605	1.03260165937737	0.899701959785507	0.717546624657917	0.579996761794785	0.689050145308768	0.681428190911401	0.620636007731051	0.770327581700795	0.873609023352376	0.843739703495393	0.746043104007065	p.Lys263Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-2.265	-2.687	0.422	19.195	19.195	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K263M	263	K	M	missense	wt-like	0.891095392787262	0.211728377603518	7	0.0800258046620125	0.73424769781588	1.04794308775864	0.672373565583827	1.0192371252265	0.856438462298382	1.01305186668414	0.556000910568386	NA	1.15801280767332	0.962553011476274	0.739972738206492	0.627012269581018	0.778074684835131	0.714094132201058	0.739972738206492	0.587816577457192	NA	0.911285319362112	0.777609922596999	p.Lys263Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-2.265	-3.431	1.166	14.268	14.268	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.38	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
K263N	263	K	N	missense	wt-like	1.05967681316426	0.124213635793928	8	0.0439161520928611	0.973602736722668	1.14575088960585	1.09725938944571	0.821384036846139	1.09207379589979	1.09179815793746	1.06122344035204	0.974931275680547	1.07860989774904	1.26013451140335	0.802849635734169	0.829162967770812	0.686867740872005	0.829662061778949	0.774507045599935	0.776536303697526	0.771858738596024	0.868519436700796	0.92706965272429	p.Lys263Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-2.265	-2.856	0.591	11.789	11.789	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K263P	263	K	P	missense	wt-like	0.995005701524312	0.129078337180182	6	0.0526960104897275	0.891723418835502	1.09828798421312	NA	0.918914469893057	0.885487192356283	1.05059647038581	0.963982061154791	0.919800091361799	NA	1.23125392399413	0.742449526818114	NA	0.731827629112459	0.728341153385654	0.756437982023849	0.740212970157362	0.744686083478866	NA	0.912564433813982	p.Lys263Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-2.265	-2.815	0.55	24.675	24.675	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.955	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K263Q	263	K	Q	missense	possibly_wt-like	0.769006869518066	0.427831933083914	8	0.151261430545892	0.47253991339811	1.06547382563802	0.502825809289876	1.11174982248699	1.17950084225278	1.11089594653602	0.138648635559176	0.745272512583228	0.237530519613093	1.12563086782337	0.720774308236717	0.546345428311029	0.820721481324323	0.872540871937427	0.782882410223471	0.431919715297765	0.658666206249962	0.415519640742275	0.859515459081446	p.Lys263Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-2.265	-3.527	1.262	7.538	7.538	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.93	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K263R	263	K	R	missense	wt-like	0.959865431312878	0.163798775290564	8	0.0579116123790048	0.846360756763385	1.07337010586237	0.980544943688945	0.968179757457831	0.714292559783209	0.95065805177653	1.01792407189116	1.27692174258395	0.962265010507636	0.808137312813762	0.757450224616034	0.773632975068032	0.754538097566758	0.644378324301691	0.712609834517001	0.760362351665309	0.920701592368083	0.805856849136257	0.700054937978763	p.Lys263Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-2.265	-2.688	0.423	13.659	13.659	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.585	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K263S	263	K	S	missense	wt-like	1.060128258558	0.131729465255444	8	0.0465733990821011	0.96884607371947	1.15141044339653	1.06211263553877	0.986959865545435	1.12789669490612	1.12020924154663	1.01505654015434	1.1725237572534	1.20496434677844	0.791302986740857	0.799703868825919	0.812440967547755	0.763195411334206	0.84723149080457	0.786966770104084	0.759291220089705	0.869246676509353	0.936573108110058	0.69159993041832	p.Lys263Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-2.265	-2.409	0.144	8.131	8.131	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.235	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K263T	263	K	T	missense	wt-like	1.26406608568233	0.0852862608276473	3	0.0492400456470188	1.16755736961706	1.36057480174759	NA	1.19547876537228	1.23715859465964	1.35956089701506	NA	NA	NA	NA	0.891934807500106	NA	0.859319114873261	0.900819258578061	0.891934807500106	NA	NA	NA	NA	p.Lys263Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-2.265	-2.924	0.659	10.251	10.251	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.585	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
K263V	263	K	V	missense	wt-like	1.03356239697528	0.139914136679159	8	0.0494671174148475	0.936608628423164	1.13051616552739	1.14463158092685	1.04604149084335	1.05078220845722	1.20534146994785	1.08384240805335	0.750401027300383	0.927196287846778	1.06026270242646	0.799920773661437	0.851701544124458	0.790431046278849	0.809410501044026	0.824301640075787	0.784985343755694	0.661193911094226	0.78696906681409	0.826684425023439	p.Lys263Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-2.265	-3.174	0.909	19.574	19.574	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.24	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K263W	263	K	W	missense	possibly_low	0.606972659652478	0.336808622195437	6	0.137501544224776	0.337474585153275	0.876470734151681	0.687794165116182	0.507124905094724	0.983735071823885	0.543235117288574	NA	0.0348448004615296	NA	0.885101898129975	0.588174299361222	0.634349028745249	0.541999569977195	0.77652706778971	0.533933878674409	NA	0.308515788737706	NA	0.738710251408996	p.Lys263Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-2.265	-4.257	1.992	15.401	15.401	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.93	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K263X	263	K	X	nonsense	low	0.0640347855273919	0.10760707370833	3	0.0621269729722124	-0.0577318439666377	0.185801415021422	NA	-0.0188250568296399	0.18565178300562	0.0252776304061955	NA	NA	NA	NA	0.306782824522666	NA	0.299545489035966	0.385105153640548	0.306782824522666	NA	NA	NA	NA	p.Lys263Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K263Y	263	K	Y	missense	possibly_low	0.678077364755549	0.432309695920964	5	0.193334773482308	0.299148171771016	1.05700655774008	1.18319272818477	0.62475961232114	0.787822821853572	0.797226451355906	NA	NA	NA	-0.00261478993764367	0.645322169682748	0.870048032530062	0.596227190268329	0.680441422390223	0.645322169682748	NA	NA	NA	0.292856269691076	p.Lys263Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	58.6	8.7	0.759	108	104	51.8	36.3	85.6521739130435	-0.6	0	0	92.18	0	0	0	0	3	33.8757880773274	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-2.265	-3.634	1.369	13.94	13.94	88.09	0.002775381	0.007142857	0.079325022	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.38	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
M264A	264	M	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.643	-2.686	0.043	12.003	12.003	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.27	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
M264C	264	M	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.643	-3.887	1.244	15.35	15.35	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
M264D	264	M	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.643	-3.481	0.838	11.321	11.321	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
M264E	264	M	E	missense	low	-0.0709028825701919	0.029544123310507	3	0.0170573075462927	-0.104334591034149	-0.0374711741062349	NA	NA	NA	-0.0917381449345203	-0.037091361077871	-0.0838791416981843	NA	NA	0.255465375901514	NA	NA	NA	0.255465375901514	0.366274178727924	0.25	NA	NA	p.Met264Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.643	-4.025	1.382	3.127	NA	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
M264F	264	M	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.643	-3.115	0.472	16.929	16.929	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.925	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
M264G	264	M	G	missense	possibly_wt-like	0.956288974907078	0.410468564087165	3	0.236984135969604	0.491808603499311	1.42076934631485	1.15823186180263	NA	NA	NA	NA	0.483970328793121	NA	1.22666473412548	0.85817223841505	0.85817223841505	NA	NA	NA	NA	0.529877496026765	NA	0.910259522119406	p.Met264Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.643	-2.781	0.138	15.561	15.561	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
M264H	264	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.643	-4.12	1.477	8.521	8.521	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M264I	264	M	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.643	-2.554	-0.089	14.667	10.578	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	neutral	neutral	medium	2.27	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
M264K	264	M	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.643	-2.554	-0.089	11.482	11.482	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
M264L	264	M	L	missense	wt-like	1.06125575703506	0.03240033415967	3	0.0187063416489193	1.02459200112068	1.09791951294944	NA	1.0833993955113	1.02406830818681	1.07629956740707	NA	NA	NA	NA	0.796308602877839	NA	0.807652411613714	0.796308602877839	0.767710114836303	NA	NA	NA	NA	p.Met264Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.643	-2.351	-0.292	27.302	27.302	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.225	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M264N	264	M	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.643	-3.715	1.072	8.724	8.724	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
M264P	264	M	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.643	-2.931	0.288	18.169	18.169	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
M264Q	264	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.643	-3.814	1.171	6.476	6.476	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
M264R	264	M	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.643	-3.379	0.736	11.183	11.183	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
M264S	264	M	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.643	-2.754	0.111	8.622	8.622	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.27	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
M264T	264	M	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.643	-2.821	0.178	12.57	12.57	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.615	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
M264V	264	M	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.643	-2.569	-0.074	24.05	24.05	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.025	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
M264W	264	M	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.643	-4.255	1.612	15.525	15.525	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
M264X	264	M	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M264Y	264	M	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met264Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	62.3	9.2	0.925	59.2	-150.7	-151.9	122.2	51.2315270935961	-1.7	0	0	88.18	0	0	0	0	6	30.2984154348045	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.643	-3.287	0.644	9.687	9.687	89.33	0.00255309	0.007194245	0.072971578	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.615	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
L265A	265	L	A	missense	wt-like	1.05466822190157	0.259472013452041	7	0.0980712028250439	0.862452196443958	1.24688424735918	NA	1.05264179415058	1.20212740316083	1.27066525169524	0.83807706307485	1.16048985521767	1.28007024906288	0.578605936948907	0.852949485238547	NA	0.793473675023288	0.883638124448952	0.852949485238547	0.693182690688014	0.863315494842008	0.977024650847364	0.584773250437994	p.Leu265Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-2.026	-3.074	1.048	7.044	7.044	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.625	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L265C	265	L	C	missense	possibly_low	0.446309728345211	0.597438789597091	2	0.422453019467986	-0.38168297497224	1.27430243166266	0.868762747813197	NA	NA	NA	NA	NA	NA	0.0238567088772245	0.5133005797898	0.720449631043788	NA	NA	NA	NA	NA	NA	0.306151528535812	p.Leu265Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-2.026	-3.576	1.55	13.312	13.312	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L265D	265	L	D	missense	wt-like	1.15892585272089	0.0853137159819483	8	0.0301629535495294	1.09980755009646	1.21804415534532	1.06709158770833	1.06518561044522	1.18085861389838	1.22416545386288	1.15460566360986	1.23454131199293	1.27945414949463	1.06550443075488	0.830937000062451	0.814809836078553	0.799256163228222	0.873206794384302	0.832556927233372	0.811418096511628	0.899813435540026	0.976692823690543	0.829317072891531	p.Leu265Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-2.026	-3.632	1.606	12.896	12.896	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
L265E	265	L	E	missense	wt-like	1.14141280963632	0.202985658054736	3	0.117193824319535	0.911717134759521	1.37110848451313	NA	0.940235464297642	1.13784326530972	1.34615969930161	NA	NA	NA	NA	0.852109810750804	NA	0.74165624871004	0.852109810750804	0.886057691588859	NA	NA	NA	NA	p.Leu265Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-2.026	-4.025	1.999	6.259	NA	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L265F	265	L	F	missense	possibly_wt-like	0.817891898967431	0.170065601816456	6	0.069428991208276	0.681813576716262	0.9539702212186	NA	0.945955963153764	0.728070403681419	NA	0.976790538526729	0.704654169343667	0.974121618205591	0.577758700893414	0.697714502088236	NA	0.74429330240924	0.651135701767232	NA	0.744997420970002	0.638646534154806	0.812242739704442	0.584347727775331	p.Leu265Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-2.026	-2.857	0.831	15.973	15.973	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.825	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
L265G	265	L	G	missense	wt-like	1.05613607561133	0.145741502491458	7	0.0550851101847569	0.948171243564783	1.16410090765787	0.826806942679715	1.04688408559661	0.963577667919396	1.05546166746507	1.02836843678165	NA	1.25565060460205	1.2162031242348	0.766640819410477	0.700488044131429	0.790819468279602	0.766640819410477	0.758571621701229	0.764263717037379	NA	0.963872391684083	0.90500519887908	p.Leu265Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-2.026	-2.857	0.831	21.255	21.255	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
L265H	265	L	H	missense	wt-like	1.00389513445706	0.173319861450204	3	0.100066268664184	0.807768851807955	1.20002141710617	0.804180220619389	1.09256155629306	NA	NA	NA	NA	NA	1.11494362645874	0.811876013538981	0.689722781076364	0.811876013538981	NA	NA	NA	NA	NA	0.854147812871739	p.Leu265His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-2.026	-3.532	1.506	13.792	13.792	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L265I	265	L	I	missense	wt-like	1.19232392607216	0.192349537196653	5	0.0860213281224682	1.02372522104982	1.3609226310945	NA	1.28137706818767	1.16352474417942	1.30183633976031	1.34495941547027	NA	0.869922062763145	NA	0.866619613950571	NA	0.8989167868406	0.864705355298849	0.866619613950571	0.882522423460983	NA	0.756121547601255	NA	p.Leu265Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-2.026	-2.761	0.735	19.741	19.741	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.475	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
L265K	265	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu265Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-2.026	-2.591	0.565	24.407	24.407	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
L265L	265	L	L	synonymous	wt-like	0.947915471792927	0.179085738536895	8	0.0633163700666197	0.823817666830543	1.07201327675531	1.22294215927776	0.899323051518679	1.01769557323639	1.02011523392884	0.681977473418585	0.957243730392954	0.719736180344939	1.06429037222526	0.753105709684342	0.888959878482136	0.722796314956802	0.793183079329599	0.74307038879776	0.634873589075357	0.763141030570923	0.675232423625728	0.82870731435399	p.Leu265=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L265M	265	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu265Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-2.026	-2.765	0.739	14.67	14.67	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.25	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L265N	265	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu265Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-2.026	-4.27	2.244	3.696	NA	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L265P	265	L	P	missense	wt-like	1.10702183457747	0.122185649311027	2	0.0863983011915083	0.937684275916669	1.27635939323827	NA	1.02062353338596	NA	NA	NA	NA	NA	1.19342013576898	0.836138141427128	NA	0.778713795664006	NA	NA	NA	NA	NA	0.89356248719025	p.Leu265Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-2.026	-2.851	0.825	14.24	14.24	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
L265Q	265	L	Q	missense	wt-like	1.22283046097088	0.24764869397797	6	0.101102155952115	1.02467387654538	1.42098704539638	NA	0.924416140930754	1.20378987149775	1.24936734526267	1.65945922740996	NA	1.06259365145954	1.23735652926461	0.872173339204373	NA	0.73436380687014	0.884453486138346	0.843609255548072	1	NA	0.8598931922704	0.915629455453506	p.Leu265Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-2.026	-3.76	1.734	5.627	5.627	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
L265R	265	L	R	missense	possibly_low	0.600456134001058	0.453275368134614	4	0.226637684067307	0.15625443568957	1.04465783231255	NA	NA	0.389719432046663	0.103048200088893	0.762413050222202	NA	NA	1.14664385364648	0.575054977146791	NA	NA	0.485190634595599	0.340889227717525	0.664919319697984	NA	NA	0.870069190382148	p.Leu265Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-2.026	-3.682	1.656	10.5	10.5	85.11	0.002328857	0	0.066562598	4.062e-06	1	246174	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
L265S	265	L	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu265Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-2.026	-2.895	0.869	9.659	9.659	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.625	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L265T	265	L	T	missense	wt-like	0.756732227970473	0.0271134975073664	2	0.0191721379491434	0.719155528083519	0.794308927857428	NA	0.775904365919616	NA	NA	NA	0.73756009002133	NA	NA	0.660383670886636	NA	0.665902377977682	NA	NA	NA	0.654864963795589	NA	NA	p.Leu265Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-2.026	-3.147	1.121	13.424	13.424	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.825	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L265V	265	L	V	missense	wt-like	1.12011299632795	0.165334477336118	8	0.0584545650441512	1.00554415410946	1.23468183854644	0.895611431849912	1.25984326176965	1.26695201333161	1.32145854368291	1.0414838914854	1.22488659752059	0.986272752900407	0.964395478083117	0.847006111144929	0.733223604470737	0.888990064486359	0.915431514127103	0.875224961722693	0.769162835495674	0.89505489044702	0.818787260567165	0.77853529787031	p.Leu265Val	1	0	NA	NA	NA	NA	NA	NA	NA	0.088	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-2.026	-2.608	0.582	12.817	10.021	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
L265W	265	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu265Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-2.026	-5.493	3.467	0.832	NA	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L265X	265	L	X	nonsense	possibly_low	0.381292394026943	0.40352327015035	5	0.180461092511839	0.0275951520929881	0.734989635960898	NA	NA	0.854469774244698	0.739584404101257	0.31709434998105	NA	0.0146871691359506	-0.0193737273282397	0.498575939811106	NA	NA	0.713128584297559	0.62004316102092	0.498575939811106	NA	0.29549768452622	0.284439125949841	p.Leu265Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L265Y	265	L	Y	missense	wt-like	1.09739399603388	0.162658699309548	4	0.0813293496547738	0.937991399824459	1.2567965922433	0.915190161287093	NA	NA	NA	1.01013075593013	1.26569980400441	1.19855526291389	NA	0.836310929332409	0.742538704206053	NA	NA	NA	0.757451253351264	0.915170605313554	0.933121217886148	NA	p.Leu265Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	0.014	33.7	63.7	9.9	0.93	79.7	74.3	-52	-60.7	93.1937172774869	-0.6	0	0	84.54	0	0	0	0	3	28.3913701300237	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-2.026	-2.655	0.629	9.609	9.609	85.11	0.002328857	0	0.066562598	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.28	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K266A	266	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.964	-3.19	1.226	6.684	6.684	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K266C	266	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.964	-5.42	3.456	0.788	NA	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K266D	266	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.964	-3.501	1.537	11.813	11.813	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K266E	266	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.964	-3.222	1.258	9.14	9.14	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K266F	266	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.964	-3.54	1.576	28.024	28.024	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K266G	266	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.964	-2.468	0.504	19.989	19.989	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K266H	266	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.964	-3.962	1.998	10.718	10.718	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K266I	266	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.964	-3.652	1.688	6.536	6.536	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K266L	266	K	L	missense	wt-like	1.04538963744295	0.0792778726544258	2	0.0560579213519881	0.93551813054487	1.15526114434102	NA	0.989331716090958	NA	1.10144755879493	NA	NA	NA	NA	0.771513799868097	NA	0.764288794518494	NA	0.7787388052177	NA	NA	NA	NA	p.Lys266Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.964	-2.958	0.994	15.002	15.002	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.825	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K266M	266	K	M	missense	wt-like	0.840356097507568	0.079682675343431	7	0.0301172203941452	0.781327430220588	0.899384764794548	NA	0.882897511369713	0.931973828559017	0.767936212481242	0.786583515581492	0.730709086520486	0.855388795748084	0.92700373229294	0.715224417382725	NA	0.715224417382725	0.751140638576946	0.632476890281956	0.67394790282087	0.651488291271042	0.748294026009864	0.759755366200641	p.Lys266Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.964	-3.75	1.786	4.301	4.301	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K266N	266	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.964	-3.203	1.239	18.547	18.547	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K266P	266	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.964	-2.743	0.779	19.151	19.151	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K266Q	266	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.964	-3.148	1.184	7.538	7.538	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K266R	266	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.964	-2.408	0.444	17.159	17.159	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.585	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
K266S	266	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.964	-2.42	0.456	8.731	8.731	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K266T	266	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.964	-3.128	1.164	7.689	7.689	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.275	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K266V	266	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.964	-3.295	1.331	9.887	9.887	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K266W	266	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.964	-5.585	3.621	1.302	NA	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K266X	266	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	2	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K266Y	266	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys266Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	32.7	66.8	11.9	0.373	75.2	-149.1	-61.2	129.1	58.695652173913	-0.6	0	0	66.82	0	0	0	0	4	24.7847460721307	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.964	-2.671	0.707	9.687	9.687	72.7	0.002294994	0	0.065594755	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.855	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K267A	267	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.873	-3.217	1.344	6.972	6.972	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K267C	267	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.873	-5.488	3.615	0.727	NA	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K267D	267	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.873	-2.398	0.525	12.01	12.01	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.155	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267E	267	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Glu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.873	-2.375	0.502	15.258	15.258	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	3.125	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.714285714285714
K267F	267	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.873	-4.565	2.692	4.008	NA	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267G	267	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Gly	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.873	-2.644	0.771	18.977	18.977	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267H	267	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.873	-3.685	1.812	10.893	10.893	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K267I	267	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.873	-3.517	1.644	7.411	7.411	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267L	267	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.873	-3.427	1.554	11.461	11.461	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267M	267	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Met	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.873	-4.046	2.173	7.797	7.797	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K267N	267	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Asn	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.873	-2.757	0.884	10.531	10.531	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	.	D	0.785714285714286
K267P	267	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.873	-2.955	1.082	20.992	20.992	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267Q	267	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Gln	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.873	-3.112	1.239	15.554	15.554	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.085	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	T	T	D	D	0.571428571428571
K267R	267	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.873	-2.714	0.841	18.867	18.867	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
K267S	267	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.873	-2.687	0.814	7.967	7.967	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K267T	267	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.873	-3.125	1.252	7.322	7.322	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K267V	267	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.873	-3.966	2.093	4.812	NA	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267W	267	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.873	-5.702	3.829	0.839	NA	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K267X	267	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K267Y	267	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys267Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	31.7	65.8	15.4	0.622	18.4	-107.7	-97.9	161.4	39.5652173913043	-0.9	0	0	47.47	0	0	0	0	5	24.1583864912374	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.873	-3.069	1.196	9.687	9.687	30.77	0.002473748	0	0.070703841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268A	268	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Ala	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.96	-3.165	1.205	7.691	7.691	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.785714285714286
D268C	268	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.96	-4.078	2.118	12.592	12.592	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268E	268	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Glu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.96	-2.067	0.107	26.979	26.979	86.1	0.002374321	0	0.067862045	0	NA	NA	not provided	not provided	no assertion provided	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	-0.29	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
D268F	268	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.96	-4.62	2.66	3.03	NA	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268G	268	D	G	missense	possibly_low	0.60960493311257	0.233867594645981	6	0.0954760457091173	0.4224753221364	0.79673454408874	0.672452853360408	NA	0.779821652341622	NA	0.437873260247347	0.352465053342993	0.456745745254909	0.958271034128139	0.585370712208851	0.627049992843348	NA	0.676517229101529	NA	0.543691431574354	0.465062137168637	0.533587512893449	0.775459307793927	p.Asp268Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.96	-2.486	0.526	16.32	16.32	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D268H	268	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268His	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.96	-3.615	1.655	9.927	9.927	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D268I	268	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.96	-3.66	1.7	7.479	7.479	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268K	268	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.96	-2.442	0.482	10.107	10.107	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.555	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D268L	268	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.96	-3.9	1.94	4.774	NA	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268M	268	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Met	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.96	-5.06	3.1	1.165	NA	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268N	268	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Asn	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.96	-2.358	0.398	9.588	9.588	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.465	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.857142857142857
D268P	268	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.96	-4.212	2.252	2.377	NA	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268Q	268	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Gln	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.96	-2.758	0.798	7.644	7.644	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.81	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D268R	268	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.96	-3.32	1.36	9.732	9.732	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.015	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268S	268	D	S	missense	possibly_wt-like	0.83151809047764	0.162579425733174	5	0.0727077295364512	0.689013559188517	0.974022621766764	1.06393676268634	NA	NA	NA	0.665300977888656	0.925555758156331	0.786041824336976	0.716755129319894	0.710944205391035	0.813308844411983	NA	NA	NA	0.628644287162783	0.747522894454536	0.710944205391035	0.654158413877691	p.Asp268Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.96	-2.543	0.583	9.659	9.659	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.015	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D268T	268	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.96	-3.365	1.405	7.322	7.322	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D268V	268	D	V	missense	wt-like	0.851249460903308	0.04354908025126	5	0.0194757407598822	0.8130777104417	0.889421211364916	NA	0.891281676489813	0.893389360036961	NA	0.803730940099869	NA	0.807948690681847	0.859896637208051	0.722743098863267	NA	0.71908937640129	0.732216790982425	NA	0.680353114524752	NA	0.722743098863267	0.726050958085648	p.Asp268Val	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.96	-3.135	1.175	9.887	9.887	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D268W	268	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.96	-5.754	3.794	0.634	NA	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D268X	268	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D268Y	268	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp268Tyr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29.1	67.7	17.4	0.767	27.2	-124.5	-92	130.8	36.3636363636364	-6.1	0	1	39.03	0	0	0	0	5	22.2287565522681	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.96	-3.775	1.815	7.325	7.325	86.1	0.002374321	0	0.067862045	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K269A	269	K	A	missense	low	0.566014611726533	0.170758581508802	8	0.0603722754653348	0.447687126149745	0.68434209730332	0.749919801168255	0.620631017359655	0.644234656817962	0.702513142379766	0.3350545923175	0.692557044806391	0.312987030903988	0.470219608058743	0.599054739766003	0.663906947598042	0.594323977473517	0.610018253286374	0.603785502058488	0.505284769717002	0.632684191843053	0.456160019173943	0.530336427351272	p.Lys269Ala	0	0	NA	NA	NA	NA	NA	NA	NA	-1.625	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.819	-2.891	1.072	10.566	10.566	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K269C	269	K	C	missense	low	0.579822842828124	0.108449384335131	6	0.0442742757566758	0.493046856903444	0.666598828752803	0.557841823727786	0.772060124075563	0.446551474420773	0.580200606103826	0.599276949937163	NA	NA	0.523006078703631	0.564684542904283	0.572520756141826	0.664130247184469	0.513064049717496	0.550145150765792	0.603981815191025	NA	NA	0.55684832966674	p.Lys269Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.819	-2.375	0.556	14.631	14.631	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269D	269	K	D	missense	possibly_low	0.585125059128305	0.201731069365035	7	0.0762471773221435	0.435683337654065	0.734566780602545	0.499223778941743	0.810310829544447	0.529530973660901	0.789026771944529	0.722412319978499	0.499786194105539	NA	0.245584545722477	0.553761549443124	0.544631666851167	0.68176317866312	0.553761549443124	0.641726187639488	0.649977533819516	0.537672704107713	NA	0.417513903766531	p.Lys269Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.819	-4.026	2.207	4.88	NA	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269E	269	K	E	missense	possibly_wt-like	0.723209082625232	0.322299732319818	6	0.131578314736527	0.465320324595164	0.981097840655299	0.736067396703366	0.236886902434341	0.762423501709002	1.23368416786047	NA	0.591066399089025	NA	0.77912612795519	0.662650281053796	0.657316298823903	0.417424398737162	0.667984263283689	0.836731373927318	NA	0.582662224280171	NA	0.685484126753275	p.Lys269Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.819	-3.37	1.551	9.361	9.361	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.857142857142857
K269F	269	K	F	missense	low	0.326312307947398	0.267479115014992	6	0.109197891439657	0.112288373537955	0.540336242356841	NA	0.516759717744847	0.730920118437424	NA	-0.000631706617802917	0.191737530249017	0.150390668930425	0.368697518940477	0.432595542929726	NA	0.546441056459254	0.652533351386267	NA	0.379893238850733	0.385843930506921	0.368586692907327	0.479347155352531	p.Lys269Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.819	-3.492	1.673	10.617	10.617	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269G	269	K	G	missense	low	0.346478958026658	0.190553205226789	8	0.0673707317963473	0.21443475009371	0.478523165959606	0.0918324961025321	0.307442294650475	0.508130613513059	0.568532182228601	0.355711023287446	0.0505774713154414	0.39289893307894	0.49670665003677	0.506100384883204	0.350804460488187	0.449949247132665	0.543265690113764	0.54502794549186	0.513000728067909	0.316269992542098	0.499200041698499	0.543639492719503	p.Lys269Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.819	-3.167	1.348	15.814	15.814	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269H	269	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys269His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.819	-3.651	1.832	11.333	11.333	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269I	269	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys269Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.819	-3.344	1.525	8.018	8.018	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K269L	269	K	L	missense	possibly_low	0.563992668217195	0.259730542809151	7	0.0981689177372613	0.371585125050887	0.756400211383502	0.775128314851525	0.665469591653166	0.695055769507109	0.717561663326045	0.0112920564460963	0.505300340877653	NA	0.578140940858767	0.610385054112358	0.675900566483893	0.614993805609395	0.63494359314336	0.610385054112358	0.384347215402683	0.540390476460249	NA	0.584539707055224	p.Lys269Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.819	-2.973	1.154	9.97	9.97	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.705	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K269M	269	K	M	missense	low	0.363083426024738	0.0909212668555253	7	0.0343650087123799	0.295729246620068	0.430437605429408	NA	0.428734072240423	0.326493747587143	0.471815032735742	0.266386231005982	0.230734710794945	0.385273255445158	0.432146932363775	0.495092902108649	NA	0.505862715314507	0.454181441969625	0.502612490520662	0.479634539206435	0.405064575784366	0.495092902108649	0.511214499959992	p.Lys269Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.819	-3.936	2.117	4.18	4.18	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269N	269	K	N	missense	possibly_low	0.622088317698567	0.0892861733668101	4	0.0446430866834051	0.534589475640393	0.70958715975674	NA	NA	0.734965868541183	NA	0.644913434745996	0.581126831045503	0.527347136461584	NA	0.59939602561402	NA	NA	0.654517599486647	NA	0.621028768586754	0.577763282641286	0.571612955726078	NA	p.Lys269Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.819	-2.742	0.923	18.547	18.547	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K269P	269	K	P	missense	wt-like	0.836731864307396	0.115651057356672	8	0.0408888234541484	0.756591242967048	0.916872485647744	0.700286779757904	1.03715058591977	0.799373208683593	0.875709980873288	0.867621019187897	0.668533306279772	0.865181486015716	0.879998547741225	0.695162406962862	0.640292721450943	0.786332488739088	0.686106338051926	0.679741242511926	0.704218475873798	0.620843547211977	0.75356830428661	0.736147103592231	p.Lys269Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.819	-3.404	1.585	17.432	17.432	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269Q	269	K	Q	missense	low	0.482787149401241	0.14285278105597	8	0.0505060850980166	0.383797041609013	0.581777257193468	0.496910054216839	0.668760899319248	0.340176119378491	0.590844949823174	0.336654236214213	0.294678767150494	0.516741364291771	0.617530804815695	0.549172047532499	0.543530850955953	0.616511043052203	0.460891994905272	0.554813244109044	0.505882297223146	0.436580854848783	0.565900756908939	0.604323189691731	p.Lys269Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.819	-3.104	1.285	6.529	6.529	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K269R	269	K	R	missense	possibly_wt-like	0.784886185334231	0.235943061622875	8	0.083418469423725	0.621388989618275	0.948383381050188	0.487210501969026	0.859002201531643	0.91325752758631	1.11546278619527	0.932588307830407	0.402227546358678	0.756597478500509	0.812743132702007	0.703288641881635	0.538916031752992	0.704209081694901	0.741961182679083	0.784885204794478	0.728486215739717	0.489588710961564	0.695085675265599	0.702368202068368	p.Lys269Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.819	-2.88	1.061	17.159	17.159	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.155	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K269S	269	K	S	missense	possibly_wt-like	0.743521116633804	0.121035037743153	8	0.0427923479746767	0.659649655789532	0.827392577478076	0.681137719447337	0.768740019337998	0.812494391792668	0.923164575341403	0.603311377549017	0.557871838971607	0.788061257198726	0.813387753431677	0.677570694696433	0.631182048196949	0.662599734776349	0.692541654616517	0.70055252805325	0.60548882651685	0.566301532142279	0.712031858587755	0.702691961577324	p.Lys269Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.819	-3.315	1.496	8.077	8.077	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269T	269	K	T	missense	possibly_low	0.638772105640326	0.17648231463799	7	0.0667040450475965	0.5080345797239	0.769509631556753	NA	0.421574260544769	0.829257864356803	0.746168203812523	0.457364037859387	0.483580717043033	0.733997713351269	0.799461942514501	0.622930496531291	NA	0.502562162619283	0.700763341012879	0.622930496531291	0.55097197430219	0.52968546703545	0.682913591075394	0.695697750102502	p.Lys269Thr	1	0	NA	NA	NA	NA	NA	NA	NA	-1.649	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.819	-2.942	1.123	7.506	7.506	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K269V	269	K	V	missense	low	0.561602348806791	0.182971248775828	8	0.0646901053857794	0.434812072094563	0.68839262551902	0.316732559604605	0.567362124296552	0.669096707958261	0.755647606768287	0.409104073478442	0.786029469020484	0.348654464610789	0.640191784716911	0.592736268539729	0.457806629792503	0.569767914263404	0.622211907486827	0.627087703307259	0.532945052046287	0.678754197004733	0.475370263309704	0.615704622816054	p.Lys269Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.819	-2.8	0.981	9.019	9.019	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K269W	269	K	W	missense	low	0.372410969765534	0.29056973827792	7	0.109825038000643	0.15715785068353	0.587664088847537	0.574094978535692	0.362919671091773	0.244465389838661	0.839193253627889	-0.103015463555234	NA	0.299965322510049	0.389253636309904	0.475523384012325	0.580253625556818	0.475523384012325	0.413950431930603	0.663726775498637	0.341649032700696	NA	0.449146613068851	0.489671425360084	p.Lys269Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.819	-5.595	3.776	0.812	NA	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K269X	269	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys269Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K269Y	269	K	Y	missense	low	0.456193115523789	0.140807228158147	5	0.0629709067769879	0.332772406167063	0.579613824880514	NA	0.497642485193229	0.316931880961458	0.659214527609739	0.327948596644617	NA	0.479228087209901	NA	0.53762833398755	NA	0.53762833398755	0.449491800938541	0.584796827818984	0.502630411530272	NA	0.545696353727061	NA	p.Lys269Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.3	69.8	20.3	0.584	29.9	178.4	-73.1	126.6	38.695652173913	-1.1	0	1	35.03	0	0	1	13	4	19.1296627743408	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.819	-3.141	1.322	9.372	9.372	24.81	0.002465911	0	0.070479841	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270A	270	M	A	missense	possibly_low	0.478232587939442	0.417067076790213	4	0.208533538395106	0.0695143631163326	0.886950812762551	NA	0.079586536272653	0.530218708209886	NA	1.03894289283854	NA	NA	0.264182214436688	0.49047669864422	NA	0.344911577232413	0.554098850546107	NA	0.768213676381137	NA	NA	0.426854546742334	p.Met270Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	84	1.9	1.8	0.0999999999999999	203	121	82	5.7	8.1	-2.4	149	89	60	5.74	6	0.26	-2.122	-2.562	0.44	8.481	8.481	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.755	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270C	270	M	C	missense	low	-0.167345512487864	0.156929659278688	3	0.0906033810283866	-0.344924876181061	0.0102338512053336	NA	NA	NA	NA	-0.348369550675429	-0.0838791416981843	-0.0697878450899775	NA	0.25	NA	NA	NA	NA	0.25	0.25	0.25	NA	p.Met270Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	196	1.9	2.5	-0.6	203	148	55	5.7	5.5	0.2	149	121	28	5.74	5.07	-0.67	-2.122	-3.13	1.008	15.59	15.59	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270D	270	M	D	missense	low	0.132064900106092	0.145202950636474	4	0.0726014753182368	-0.0102313767421253	0.27436117695431	NA	-0.0753119934294646	NA	NA	0.255624602057748	NA	0.146891639432241	0.201055352363845	0.380925670830998	NA	0.273505961913678	NA	NA	0.475614663707454	NA	0.366702138738084	0.395149202923911	p.Met270Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	160	1.9	-3.5	5.4	203	187	16	5.7	13	-7.3	149	133	16	5.74	5.05	-0.69	-2.122	-4.236	2.114	2.068	NA	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.755	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270E	270	M	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met270Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	126	1.9	-3.5	5.4	203	214	-11	5.7	12.3	-6.6	149	147	2	5.74	3.22	-2.52	-2.122	-4.1	1.978	1.748	NA	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270F	270	M	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met270Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	28	1.9	2.8	-0.9	203	228	-25	5.7	5.2	0.5	149	165	-16	5.74	3.32	-2.42	-2.122	-3.653	1.531	10.043	10.043	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270G	270	M	G	missense	low	0.259789862535537	0.0695033796533817	8	0.0245731555341447	0.211627362702113	0.307952362368962	0.309596382025492	0.240354590079361	0.294275276961088	0.383561742698984	0.150247513424949	0.226053421750017	0.225242255733766	0.248987717610644	0.427737737586732	0.454411404065949	0.419022944381862	0.438379813718415	0.463908874158492	0.436252334938582	0.402757296260202	0.408901263006803	0.419223140234882	p.Met270Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	127	1.9	-9.4	11.3	203	97	106	5.7	9	-3.3	149	75	74	5.74	3.29	-2.45	-2.122	-3.417	1.295	18.471	18.471	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270H	270	M	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met270His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	87	1.9	-3.2	5.1	203	216	-13	5.7	10.4	-4.7	149	155	-6	5.74	7.59	1.85	-2.122	-3.314	1.192	9.751	9.751	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270I	270	M	I	missense	possibly_wt-like	0.808392408617036	0.27785246233827	7	0.105018359502001	0.602560206277635	1.01422461095644	NA	0.407168206356399	0.783489758143493	0.765473574050465	1.21433352017474	0.990282052359902	0.966763440647272	0.531236308586987	0.678316260624161	NA	0.495921214085984	0.678316260624161	0.631396896402704	0.833728710301302	0.779424717191314	0.808279673887834	0.560981946634035	p.Met270Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	10	1.9	4.5	-2.6	203	191	12	5.7	5.2	0.5	149	131	18	5.74	6.02	0.28	-2.122	-2.155	0.033	10.713	10.713	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	3	0	0	0	0	0	0	0.00201009045407043	0.00211627618180313	0.00211627618180313	0.0019697038512013	0.00207358653097226	0.00211945948510842	0.00265345166450384	deleterious	neutral	medium	2.41	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
M270K	270	M	K	missense	low	0.546216068059925	0.120462521436025	3	0.0695490691783501	0.409902397312074	0.682529738807776	NA	0.441102665198241	0.677668894077801	NA	NA	NA	NA	0.519876644903734	0.555276577621339	NA	0.511564428510096	0.626416157276748	NA	NA	NA	NA	0.555276577621339	p.Met270Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	95	1.9	-3.9	5.8	203	230	-27	5.7	11.3	-5.6	149	146	3	5.74	9.74	4	-2.122	-4.034	1.912	4.046	NA	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.105	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
M270L	270	M	L	missense	possibly_wt-like	0.950918260384213	0.415122488847123	5	0.185648420810213	0.58705404180946	1.31478247895897	NA	0.801234710361078	0.888070347890134	0.549675051766147	1.65378281234719	NA	NA	0.861828379556519	0.727021171926724	NA	0.677579240466671	0.729608068377825	0.536758121864818	0.99787964424878	NA	NA	0.727021171926724	p.Met270Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	15	1.9	3.8	-1.9	203	191	12	5.7	4.9	0.8	149	131	18	5.74	9.71	3.97	-2.122	-2.171	0.049	15.934	15.934	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
M270N	270	M	N	missense	low	0.231967133958565	0.107788788144749	6	0.0440045884912652	0.14571972536118	0.318214542555951	NA	0.225106316387752	0.104468961180459	0.126317549052564	0.225032154254292	0.348776668316626	0.362101154559697	NA	0.437618989875374	NA	0.411993746831752	0.345288838777112	0.351094036568416	0.464187227213357	0.463244232918997	0.482612561672402	NA	p.Met270Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	142	1.9	-3.5	5.4	203	187	16	5.7	11.6	-5.9	149	132	17	5.74	5.47	-0.27	-2.122	-3.668	1.546	7.859	7.859	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270P	270	M	P	missense	low	0.170409346411526	0.20268114907815	3	0.117018015979933	-0.0589417504514747	0.399760443274527	NA	-0.0409327112071696	NA	NA	NA	0.363146724649119	NA	0.189014025792628	0.389101470050229	NA	0.289354232429998	NA	NA	NA	0.470326841238807	NA	0.389101470050229	p.Met270Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	87	1.9	-1.6	3.5	203	154	49	5.7	8	-2.3	149	115	34	5.74	6.3	0.56	-2.122	-2.438	0.316	15.1	15.1	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270Q	270	M	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met270Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	101	1.9	-3.5	5.4	203	214	-11	5.7	10.5	-4.8	149	146	3	5.74	6.24	0.5	-2.122	-4.421	2.299	1.613	NA	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270R	270	M	R	missense	low	0.238800246240166	0.142866756463998	8	0.0505110261509099	0.139800454162222	0.337800038318111	0.162990310960802	0.51101883580631	0.359154103893898	0.245249734491809	0.0727057236706907	0.106552104394419	0.186910454512773	0.265820702190628	0.405269736517915	0.38465967793111	0.543794606502099	0.470199794141004	0.403251929791861	0.407287543243969	0.343858360518574	0.388256008131673	0.427677474033112	p.Met270Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	91	1.9	-4.5	6.4	203	265	-62	5.7	10.5	-4.8	149	174	-25	5.74	6.34	0.6	-2.122	-3.47	1.348	11.525	11.525	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M270S	270	M	S	missense	low	0.250764355153707	0.047636559814422	8	0.0168420672385882	0.217754509940872	0.283774200366542	0.187135398535123	0.257448535688459	0.282456342897536	0.289918814389275	0.259056244334307	0.223591603304209	0.188313953284446	0.318193948796303	0.424872294624632	0.39614734364478	0.426902965624091	0.432583188404774	0.422841623625174	0.47689651190861	0.401543933180565	0.389011923297023	0.453981835377793	p.Met270Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	135	1.9	-0.8	2.7	203	143	60	5.7	9.2	-3.5	149	105	44	5.74	5.68	-0.06	-2.122	-3.101	0.979	6.603	6.603	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.755	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270T	270	M	T	missense	low	0.35461750988376	0.139597470335954	5	0.0624298866316405	0.232257180526826	0.476977839240694	NA	0.276472505678774	0.428719116617584	0.391483398500076	0.517725585538873	NA	NA	0.158686943083494	0.467382928518969	NA	0.435672695624601	0.504318125923687	0.467382928518969	0.573519295694198	NA	NA	0.373869751686131	p.Met270Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	81	1.9	-0.7	2.6	203	163	40	5.7	8.6	-2.9	149	119	30	5.74	5.6	-0.14	-2.122	-3.396	1.274	9.031	9.031	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
M270V	270	M	V	missense	low	0.250173145559464	0.180663473344499	8	0.0638741835573051	0.124982046245246	0.375364244873682	0.322681340700522	0.381873824473739	0.33149023902784	0.499258317838029	-0.0312608646268628	0.0345030135107358	0.157953535890359	0.304885757661349	0.451964902869143	0.460636920153776	0.484260929731369	0.45663198349975	0.514647785498041	0.368452089706182	0.308347331283867	0.37266000308324	0.447297822238535	p.Met270Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	21	1.9	4.2	-2.3	203	165	38	5.7	5.9	-0.2	149	117	32	5.74	5.61	-0.13	-2.122	-2.501	0.379	13.428	13.428	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.555	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.5
M270W	270	M	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Met270Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	67	1.9	-0.9	2.8	203	264	-61	5.7	5.4	0.3	149	204	-55	5.74	5.89	0.15	-2.122	-5.61	3.488	0.969	NA	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
M270X	270	M	X	nonsense	low	0.0719189202483132	0.0783558266058005	3	0.0452387575834346	-0.0167474153205568	0.160585255817183	NA	0.10167353778344	-0.0169559061437085	0.131039129105208	NA	NA	NA	NA	0.353164692777433	NA	0.355093313214391	0.285735713609299	0.353164692777433	NA	NA	NA	NA	p.Met270Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	NA	1.9	NA	NA	203	NA	NA	5.7	NA	NA	149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
M270Y	270	M	Y	missense	low	0.539636397954069	0.112116586619995	3	0.0647305414656763	0.412766867981567	0.666505927926571	NA	0.610749034218838	0.410392440733463	0.597767718909907	NA	NA	NA	NA	0.557849235161448	NA	0.589768549555019	0.495329762609908	0.557849235161448	NA	NA	NA	NA	p.Met270Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.5	68.6	23.5	0.902	50.7	-58.9	-92.9	-64.2	0.492610837438424	-3.4	0	1	25.5	0	0	0	0	5	20.2785827379529	36	1.9	-1.3	3.2	203	255	-52	5.7	6.2	-0.5	149	181	-32	5.74	5.66	-0.08	-2.122	-3.718	1.596	11.184	11.184	42.43	0.002094791	0	0.059872602	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.105	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271A	271	F	A	missense	low	0.274230209268692	0.0347620037833827	4	0.0173810018916913	0.240164071545754	0.308296346991629	NA	0.277493174134541	0.250880101873962	0.322139131571771	NA	NA	NA	0.246408429494493	0.42703545219775	NA	0.43614320660531	0.417096543243485	0.436971893383722	NA	NA	NA	0.417927697790191	p.Phe271Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.321	-2.845	1.524	10.063	10.063	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271C	271	F	C	missense	possibly_low	0.547033167759972	0.331328414855456	7	0.125230369713825	0.30158615335024	0.792480182169705	0.610274267162181	0.918058112890174	0.825733055290598	NA	0.0301052920187313	0.433010543837743	0.226955850912415	0.785095052207963	0.597466881554345	0.597466881554345	0.731432862946241	0.699034589727099	NA	0.391374670548999	0.504760809734826	0.409824194048108	0.688482007361405	p.Phe271Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.321	-2.358	1.037	26.503	26.503	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.315	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
F271D	271	F	D	missense	low	0.190284582978235	0.0119505987918247	2	0.00845034944493904	0.173722202409376	0.206846963547093	0.198734932423174	NA	NA	NA	NA	NA	NA	0.181834233533296	0.393580781418497	0.401666129498431	NA	NA	NA	NA	NA	NA	0.385495433338562	p.Phe271Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.321	-4.252	2.931	1.057	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271E	271	F	E	missense	low	0.319202658964261	0.331760158502173	8	0.117294928902205	0.0893088227467524	0.549096495181769	1.00120017358851	0.22584421114317	0.359089741142949	0.494373675802876	-0.145191717146859	0.126515459289265	0.265929659737164	0.225860068157011	0.421574566936181	0.783460248445891	0.412333903895556	0.470168227271319	0.512505618205282	0.325894606556908	0.353697752946692	0.430815229976805	0.407607323234613	p.Phe271Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.321	-4.209	2.888	1.399	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271G	271	F	G	missense	low	0.297872486912914	0.0758662285583633	8	0.0268227623383336	0.245300838763903	0.350444135061925	0.337869585404259	0.290833656941487	0.304787881775758	0.408646768958968	0.150659319208169	0.348694836721961	0.253493281769628	0.287994564523083	0.442914345650096	0.467863130346508	0.442292944664869	0.443535746635323	0.474909951086015	0.436406159976248	0.463203900360809	0.42411707897203	0.43881425330501	p.Phe271Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.321	-2.663	1.342	15.814	15.814	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271H	271	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe271His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.321	-4.996	3.675	0.521	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271I	271	F	I	missense	low	0.391008007696823	0.340678367578508	5	0.152355997673841	0.0923957394274265	0.689620275966219	0.948044466220545	0.123417860738737	0.1612017067991	0.479008833079677	NA	NA	NA	0.243367171646056	0.416400231945082	0.758170011036842	0.365117080149418	0.373113553560787	0.505767342748627	NA	NA	NA	0.416400231945082	p.Phe271Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.321	-2.981	1.66	10.039	10.039	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F271K	271	F	K	missense	low	0.33211801883699	0.109017271442958	3	0.0629411510139102	0.208755629704229	0.455480407969751	NA	NA	0.212261447703422	0.425371478671067	NA	NA	NA	0.358721130136481	0.474336533460191	NA	NA	0.398155929213488	0.482244598306489	NA	NA	NA	0.474336533460191	p.Phe271Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.321	-4.161	2.84	1.567	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271L	271	F	L	missense	possibly_wt-like	0.813226512360797	0.477200891734936	4	0.238600445867468	0.345578231765361	1.28087479295623	NA	0.399323501015843	NA	NA	1.40746927294773	NA	0.989946783051619	0.456166492427994	0.672022173131647	NA	0.492304936946918	NA	NA	0.905872219827983	NA	0.820766068931879	0.523278277331415	p.Phe271Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.321	-2.268	0.947	12.02	12.02	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F271M	271	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe271Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.321	-3.628	2.307	4.059	4.059	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271N	271	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe271Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.321	-4.398	3.077	1.196	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271P	271	F	P	missense	low	0.229267781218162	0.077725905660003	8	0.027480257483027	0.175407466265542	0.283128096170782	0.199924141215685	0.30041158856916	0.159675352224997	0.302341033639957	0.140575293387377	0.35227402979148	0.192581765979045	0.186359044937595	0.415260667070347	0.402231927117929	0.446708209952862	0.372364949201523	0.428289407022766	0.43263939487748	0.464967986876953	0.391310539016418	0.387768011074507	p.Phe271Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.321	-4.492	3.171	1.01	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271Q	271	F	Q	missense	low	0.235585890947356	0.18552148472215	3	0.107110879144793	0.0256524254711405	0.445519356423572	NA	0.0393212087691747	0.259365342444757	0.408071121628138	NA	NA	NA	NA	0.421258150374935	NA	0.326349938901013	0.421258150374935	0.474657500061888	NA	NA	NA	NA	p.Phe271Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.321	-4.579	3.258	0.936	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271R	271	F	R	missense	low	0.295603327363766	0.13572496358052	7	0.0512992143339077	0.195058714834106	0.396147939893426	0.218700235149991	0.10058692362738	0.336822498789115	0.499462307818349	0.423108698561936	0.276896969896723	NA	0.213645657702869	0.427816692603575	0.411165151727774	0.354592402375685	0.459247203429476	0.514737245618301	0.538176309276616	0.427816692603575	NA	0.401472659317039	p.Phe271Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.321	-4.423	3.102	1.27	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271S	271	F	S	missense	low	0.355379354210899	0.10778423801512	5	0.048202576620965	0.260904040071775	0.449854668350023	0.257897491720725	0.324377128927894	0.289248003915288	0.373015947636092	NA	NA	NA	0.532358198854496	0.457755920728763	0.429814286007843	0.457755920728763	0.435914175274274	0.459283999480412	NA	NA	NA	0.56154541384102	p.Phe271Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.321	-3.849	2.528	2.927	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	3	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F271T	271	F	T	missense	low	0.0783021516631588	0.113062311383148	3	0.0652765559122618	-0.0496375469596895	0.206241850286007	0.137440161239886	NA	NA	NA	NA	-0.0520642148108022	NA	0.149530508560392	0.36927095023817	0.372503516640551	NA	NA	NA	NA	0.265680708596613	NA	0.36927095023817	p.Phe271Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.321	-3.869	2.548	2.923	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271V	271	F	V	missense	low	0.241388223643933	0.192015467687677	7	0.0725750250541931	0.0991437883606226	0.383632658927244	0.238222407336178	0.395976125454391	0.240723025604527	0.480487342261131	-0.124360037392986	NA	0.174193694344122	0.284475007900168	0.420453342851095	0.420453342851095	0.490761853147943	0.412114980177019	0.506415745228841	0.333676026957856	NA	0.381406845125894	0.437046562829771	p.Phe271Val	1	0	NA	NA	NA	NA	NA	NA	NA	11.499	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.321	-2.898	1.577	15.766	15.766	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F271W	271	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe271Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.321	-3.158	1.837	17.989	17.989	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F271X	271	F	X	nonsense	low	0.0242149512403525	0.0569850660424297	5	0.0254844962746375	-0.0257337436220822	0.0741636461027872	0.0196369112478625	-0.0594954586272868	0.0857021463002095	0.0677898313345971	NA	NA	NA	0.00744132594638029	0.316455496449001	0.316455496449001	0.280797118272177	0.336084608208912	0.325426615759899	NA	NA	NA	0.297906934354449	p.Phe271Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F271Y	271	F	Y	missense	low	0.298966671406106	0.169477255918668	6	0.0691888000013026	0.163359115270008	0.434574227542204	NA	0.480309480909467	0.21126416515806	0.358268621946974	0.174209425974701	0.0804756982543995	0.489272636193034	NA	0.449009776384412	NA	0.529638110719554	0.397666809533472	0.452816537070774	0.44520301569805	0.33100601207924	0.551106281443918	NA	p.Phe271Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	70.8	26.3	0.958	43.9	-155.8	-168.8	175.7	0.43859649122807	-4.1	0	1	18.39	0	0	0	0	8	17.7476048485422	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.321	-3.807	2.486	2.467	NA	58.56	0.002263942	0	0.064707244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.21	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H272A	272	H	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.929	-3.587	1.658	3.772	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272C	272	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.929	-4.014	2.085	28.302	28.302	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.335	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272D	272	H	D	missense	low	0.364845389904181	0.0330299346157459	3	0.0190698416417166	0.327469187095534	0.402221592712827	NA	NA	NA	NA	0.330420155914215	0.367839918797292	0.396276095001034	NA	0.501018958796453	NA	NA	NA	NA	0.503553632410673	0.472639988463232	0.501018958796453	NA	p.His272Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.929	-4.024	2.095	3.06	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H272E	272	H	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.929	-3.762	1.833	5.28	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272F	272	H	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.929	-2.374	0.445	11.765	11.765	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272G	272	H	G	missense	possibly_wt-like	0.714913007334678	0.0753764753473544	2	0.053299216860055	0.61044846188478	0.819377552784575	0.768212224194733	NA	NA	NA	NA	NA	NA	0.661613790474623	0.649536918265629	0.672610052947087	NA	NA	NA	NA	NA	NA	0.626463783584171	p.His272Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.929	-3.321	1.392	18.724	18.724	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272I	272	H	I	missense	low	0.296490865236991	0.279698703098034	8	0.0988884248248512	0.102673114092386	0.490308616381596	0.32523583601005	0.465269209960458	0.310594182035765	0.436111552650939	-0.348369550675429	0.241990443915904	0.568546466429974	0.372548781568265	0.471566866781895	0.461852289039587	0.522704798933188	0.446383460894898	0.486954674303034	0.25	0.410612219245429	0.593802642638473	0.481281444524203	p.His272Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.929	-4.12	2.191	6.111	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272K	272	H	K	missense	possibly_wt-like	0.774411597773052	0.0827315299743466	4	0.0413657649871733	0.693336188205244	0.855487007340859	NA	0.766289898820542	0.66183577810321	0.818787012308003	NA	NA	NA	0.850733701860452	0.658123928684909	NA	0.66147027045225	0.618650766560577	0.654777586917567	NA	NA	NA	0.721448891611215	p.His272Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.929	-3.012	1.083	7.632	7.632	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H272L	272	H	L	missense	low	0.419108934811442	0.0941406936662874	8	0.0332837614385186	0.353873961121922	0.484343908500961	0.5990927018195	0.372017450655214	0.375670740129681	0.279826339513262	0.482043278428172	0.379595512278533	0.443894752355622	0.42073070331155	0.492599014190045	0.592146955320203	0.479717307279453	0.478300419052332	0.41841555321371	0.560190604211578	0.478433999444684	0.52666605302584	0.505480721100637	p.His272Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.929	-3.094	1.165	14.909	14.909	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H272M	272	H	M	missense	wt-like	0.930279550108413	0.0901931794817523	2	0.0637762088283224	0.805280477734396	1.05527862248243	NA	NA	NA	NA	0.994055758936736	NA	0.866503341280091	NA	0.752863440346852	NA	NA	NA	NA	0.751446633895346	NA	0.754280246798357	NA	p.His272Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.929	-3.894	1.965	4.944	4.944	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272N	272	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.929	-3.251	1.322	11.631	11.631	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H272P	272	H	P	missense	low	0.320483949028954	0.194255357302938	7	0.0734216237522243	0.176580210788144	0.464387687269764	NA	0.195599675330558	0.275680716630668	0.60853637480232	0.553534193186227	0.0654777385968113	0.302654830697777	0.241904113958318	0.429260065818328	NA	0.398391681888141	0.429260065818328	0.562571845799789	0.586895165204906	0.32361392735854	0.45059516440888	0.415665414064187	p.His272Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.929	-4.355	2.426	1.263	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Sep 2, 2016)	criteria provided, single submitter	0	1	0	0	0	2	3	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
H272Q	272	H	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.929	-2.404	0.475	10.935	10.935	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	1.99	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
H272R	272	H	R	missense	wt-like	1.00526973766529	0.115222178662874	5	0.0515289248011624	0.904274900892944	1.10626457443765	NA	0.975884038112485	1.01014817494738	1.13480388486152	0.830439361039029	1.07507322936607	NA	NA	0.78948143925453	NA	0.758089641288907	0.78948143925453	0.793367273423188	0.690329720061541	0.821215972689211	NA	NA	p.His272Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.929	-2.485	0.556	13.745	13.745	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
H272S	272	H	S	missense	possibly_wt-like	0.722142491540777	0.286122691557104	6	0.116809099691107	0.493200863079659	0.951084120001896	0.507001138446173	0.919727870637299	0.805509383294959	0.976548050396514	0.244966700250473	NA	NA	0.879101806219245	0.706539886656509	0.548331951882105	0.732202593166379	0.689115839999386	0.723963933313631	0.471633534219372	NA	NA	0.735696716905217	p.His272Ser	0	0	NA	NA	NA	NA	NA	NA	NA	-0.619	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.929	-3.024	1.095	7.585	7.585	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.68	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272T	272	H	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.929	-3.222	1.293	9.153	9.153	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272V	272	H	V	missense	possibly_low	0.627478459560417	0.126600781079101	5	0.0566175904994877	0.516510021289984	0.73844689783085	0.572149127915122	0.840901769627428	0.574563188592685	0.515018909965009	NA	NA	NA	0.63475930170184	0.579327835522342	0.579327835522342	0.695865087209345	0.575847710140807	0.521559617465656	NA	NA	NA	0.612976168777236	p.His272Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.929	-3.396	1.467	10.021	10.021	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272W	272	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.929	-5.291	3.362	0.873	NA	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.03	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
H272X	272	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H272Y	272	H	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His272Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.1	71.7	28.1	0.974	4.6	-169.7	-159.5	163.1	14.3518518518519	-2.6	0	1	17.96	0	0	0	0	6	16.4395455490716	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.929	-2.186	0.257	10.081	10.081	24.81	0.00214902	0	0.061422573	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.68	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F273A	273	F	A	missense	low	0.568821475991754	0.064563116783415	8	0.0228265088460459	0.52408234076072	0.613560611222789	0.574205039478652	0.45780469262666	0.599487057078825	0.672040607425401	0.581552458792433	0.601999627717124	0.5564163468409	0.507065977974039	0.587660177228581	0.580305989969122	0.519263782066842	0.588071682810743	0.590421724889781	0.597361047273144	0.588050914084307	0.587269440372854	0.548842445047465	p.Phe273Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.438	-2.739	1.301	9.631	9.631	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273C	273	F	C	missense	wt-like	1.08942589232712	0.33847771630228	5	0.151371836504158	0.792742544505287	1.38610924014896	1.03393509951153	0.773860552310777	0.916201346058092	1.06367323634525	1.65945922740996	NA	NA	NA	0.762172817889357	0.799034757546672	0.664960214300489	0.743404985697235	0.762172817889357	1	NA	NA	NA	p.Phe273Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.438	-3.037	1.599	14.631	14.631	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F273D	273	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.438	-4.305	2.867	0.971	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273E	273	F	E	missense	low	0.29246110470551	0.13371594506576	8	0.0472757257543835	0.199802384883926	0.385119824527095	0.309915552477011	0.356288395728642	0.350147452964733	0.464773487641465	0.0420616301120934	0.336927232872603	0.146150789491919	0.333424296355617	0.459517608821642	0.454563257872295	0.472466477671361	0.465782460015406	0.499524410067091	0.39584081510669	0.457403969796915	0.366303121855105	0.46163124784637	p.Phe273Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.438	-4.184	2.746	1.339	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273G	273	F	G	missense	low	0.245471498988877	0.142029940157586	8	0.0502151669084744	0.1470515803706	0.343891417607155	0.337046160218692	0.198556418210941	0.306015547468741	0.381192973407627	0.0056854784420518	0.0619802118155623	0.355910676762097	0.317384525585305	0.448856581220089	0.467471363978177	0.399754690595319	0.44413785829737	0.462870046735004	0.382252946434668	0.321890091925577	0.479278411231793	0.453575304142807	p.Phe273Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.438	-3.951	2.513	2.606	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273H	273	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.438	-4.972	3.534	1.731	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273I	273	F	I	missense	possibly_low	0.579859082316034	0.193431724183985	4	0.0967158620919923	0.390299475881986	0.769418688750082	NA	0.568652782551755	0.562394106488373	0.83020941055019	NA	NA	NA	0.358180029673819	0.570121119928118	NA	0.570362885997844	0.569879353858393	0.659786897270954	NA	NA	NA	0.474064766804196	p.Phe273Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.438	-2.402	0.964	13.812	13.812	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F273K	273	F	K	missense	low	0.385598281556957	0.0326198529527894	2	0.0230657192242254	0.340390302599962	0.430806260513951	0.408664000781182	NA	NA	NA	NA	NA	NA	0.362532562332731	0.488898134362127	0.50154545084924	NA	NA	NA	NA	NA	NA	0.476250817875014	p.Phe273Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.438	-4.14	2.702	1.751	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273L	273	F	L	missense	wt-like	0.946763731217064	0.102023390291013	4	0.0510116951455063	0.846782645941535	1.04674481649259	NA	0.893442050925994	1.09886432036543	0.910973711952359	NA	NA	NA	0.883774841624479	0.729064506257924	NA	0.72008527265822	0.832992491223663	0.695206206125346	NA	NA	NA	0.738043739857627	p.Phe273Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.438	-2.085	0.647	14.722	14.722	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.575	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F273M	273	F	M	missense	low	0.589261605628031	0.0927534777802816	4	0.0463767388901408	0.498364867682936	0.680158343573125	NA	0.519264309551719	0.688023202575332	0.648168117102605	0.501590793282465	NA	NA	NA	0.573722373955956	NA	0.547595631131046	0.631494453375136	0.57995240746628	0.567492340445631	NA	NA	NA	p.Phe273Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.438	-3.165	1.727	7.797	7.797	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273N	273	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.438	-4.454	3.016	1.02	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273P	273	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.438	-4.47	3.032	0.966	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273Q	273	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.438	-4.548	3.11	1.425	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273R	273	F	R	missense	low	0.236103567039203	0.154482593934681	8	0.0546178448732502	0.129054558174437	0.343152575903969	0.216002474393613	0.166796259325452	0.36187776519095	0.522663326964325	0.0899411489406915	0.123982105923624	0.085700228581609	0.321865226993358	0.411803623531914	0.409881620506388	0.385113791858576	0.47153562053071	0.524912088322331	0.413725626557441	0.35244913225869	0.333744849152428	0.455825727718845	p.Phe273Arg	0	0	NA	NA	NA	NA	NA	NA	NA	15.496	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.438	-4.423	2.985	1.547	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273S	273	F	S	missense	low	0.206734954091487	0.178403405292655	5	0.0797844283303644	0.0503603480368554	0.363109560146118	NA	0.172222578669237	0.311932596943139	0.455232297252093	NA	0.0127652184089292	NA	0.0815220791840342	0.387615233753499	NA	0.387615233753499	0.447039889781846	0.495340106316887	NA	0.297633365737729	NA	0.33511384872661	p.Phe273Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.438	-3.9	2.462	2.801	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F273T	273	F	T	missense	low	0.472022188840261	0.064254294229273	6	0.0262317057740627	0.420608990270047	0.523435387410475	0.465978090581178	0.409470988034612	0.417281911376978	0.501009589813511	0.584028102449245	NA	NA	0.454364450786042	0.518894506970067	0.528814148975887	0.49698275768484	0.498708720451203	0.51541580852196	0.598285793826672	NA	NA	0.522373205418173	p.Phe273Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.438	-3.831	2.393	2.019	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273V	273	F	V	missense	low	0.614089842202797	0.08927671875052	6	0.0364470678081229	0.542654901956787	0.685524782448807	0.711465405088088	0.546101681674972	0.599637526479638	0.690948252893918	NA	0.655994473186899	NA	0.480391713893265	0.593429591424732	0.645611248896173	0.559967208018729	0.588145480898878	0.598713701950586	NA	0.614663498816239	NA	0.535445347741909	p.Phe273Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.438	-2.159	0.721	9.887	9.887	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.27	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F273W	273	F	W	missense	low	0.299536494274303	0.126280263127218	5	0.0564742505138041	0.188848997213355	0.410223991335252	0.175463444944484	0.177284630343152	0.29737269027852	0.459622004304328	NA	NA	NA	0.387939701501034	0.439898947706818	0.390594102197135	0.389948754383077	0.439898947706818	0.49726521911009	NA	NA	NA	0.489011504155349	p.Phe273Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.438	-5.138	3.7	1.01	NA	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F273X	273	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe273Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F273Y	273	F	Y	missense	low	0.240098725880839	0.160993703274443	2	0.113839739313693	0.0169769368165715	0.463220514945106	NA	0.126258986567146	NA	NA	NA	NA	NA	0.353938465194532	0.4191806203137	NA	0.366426791341419	NA	NA	NA	NA	NA	0.47193444928598	p.Phe273Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.4	73.1	31.5	0.971	13.4	-142.8	-160.3	146	1.31578947368421	-4.8	0	1	20.3	0	0	0	0	8	16.0198888217116	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.438	-2.911	1.473	11.656	11.656	50.87	0.001615826	0	0.04618301	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.27	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W274A	274	W	A	missense	low	0.435603625047333	0.097911336952338	6	0.0399721359278233	0.35725967824366	0.513947571851006	NA	0.330400660347656	0.441385707015752	0.49977131040525	0.373668526766689	NA	0.594097323865654	0.374298221882995	0.512701622776439	NA	0.460532667339896	0.510530486373855	0.514872759179023	0.519708534907033	NA	0.607564165635958	0.482160097523053	p.Trp274Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	148	-0.9	1.8	-2.7	264	121	143	5.4	8.1	-2.7	204	89	115	5.89	6	0.11	-1.254	-2.388	1.134	8.122	8.122	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274C	274	W	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	215	-0.9	2.5	-3.4	264	148	116	5.4	5.5	-0.0999999999999996	204	121	83	5.89	5.07	-0.82	-1.254	-3.111	1.857	17.749	17.749	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W274D	274	W	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	181	-0.9	-3.5	2.6	264	187	77	5.4	13	-7.6	204	133	71	5.89	5.05	-0.84	-1.254	-4.099	2.845	2.186	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274E	274	W	E	missense	low	0.421546256003155	0.15925569818507	7	0.0601929960382364	0.30357015164665	0.539522360359661	NA	0.238989418358728	0.436123413999064	0.368253351888142	0.507600522119301	0.727677495418515	0.341892915620039	0.330286674618297	0.471728537697596	NA	0.418393623193889	0.507949581806293	0.457195355775005	0.569737201499931	0.649994102809683	0.471728537697596	0.460055383425308	p.Trp274Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	152	-0.9	-3.5	2.6	264	214	50	5.4	12.3	-6.9	204	147	57	5.89	3.22	-2.67	-1.254	-3.919	2.665	2.512	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274F	274	W	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	40	-0.9	2.8	-3.7	264	228	36	5.4	5.2	0.2	204	165	39	5.89	3.32	-2.57	-1.254	-4.012	2.758	1.345	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274G	274	W	G	missense	low	0.287256589043169	0.170316440100756	8	0.0602159548713984	0.169235486200539	0.4052776918858	0.581888208807665	0.240749736101938	0.301441539174517	0.433609261611138	0.00879499183946888	0.316443420646153	0.181410411217834	0.233715142946642	0.430549812357433	0.583961461526288	0.419205100048137	0.441894524666728	0.485857290710981	0.383414467314096	0.447308058163747	0.38529372115242	0.411552519285025	p.Trp274Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	184	-0.9	-9.4	8.5	264	97	167	5.4	9	-3.6	204	75	129	5.89	3.29	-2.6	-1.254	-2.822	1.568	32.767	32.767	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.565	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.928571428571429
W274H	274	W	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	115	-0.9	-3.2	2.3	264	216	48	5.4	10.4	-5	204	155	49	5.89	7.59	1.7	-1.254	-4.968	3.714	0.83	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274I	274	W	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	61	-0.9	4.5	-5.4	264	191	73	5.4	5.2	0.2	204	131	73	5.89	6.02	0.13	-1.254	-4.06	2.806	6.03	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274K	274	W	K	missense	low	0.210050687766085	0.207341587687846	4	0.103670793843923	0.00685966558331941	0.413241709948851	NA	-0.0280238419969197	0.159934905961952	0.473002271239647	NA	NA	NA	0.235289415859661	0.392417721383822	NA	0.295305003885348	0.372492247970921	0.503133155796329	NA	NA	NA	0.412343194796722	p.Trp274Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	110	-0.9	-3.9	3	264	230	34	5.4	11.3	-5.9	204	146	58	5.89	9.74	3.85	-1.254	-3.951	2.697	2.201	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274L	274	W	L	missense	low	0.306828977730936	0.167737967111058	7	0.0633989923427701	0.182569236082976	0.431088719378896	NA	0.472857861794367	0.466863843278325	0.393157998132597	0.0225023905559345	0.158665750619501	0.367822616065345	0.265932383670482	0.468117326768715	NA	0.526203039714956	0.523026301039535	0.468117326768715	0.388534699252973	0.36954375351838	0.485694103037008	0.427733565839367	p.Trp274Leu	1	0	NA	NA	NA	NA	NA	NA	NA	9.611	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	61	-0.9	3.8	-4.7	264	191	73	5.4	4.9	0.5	204	131	73	5.89	9.71	3.82	-1.254	-3.066	1.812	9.225	9.225	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W274M	274	W	M	missense	low	0.272884069188979	0.223214873361548	8	0.0789183753078237	0.118206895867229	0.427561242510728	0.423943160405226	0.187039669172818	0.513599261134142	0.507510824872931	-0.00233330266333021	-0.0330029841893333	0.160005837031676	0.426310087747702	0.451364309601655	0.508814916226267	0.394445663110552	0.545947801805165	0.518266935177015	0.379257628360399	0.275075468607412	0.37376535891817	0.508282956092759	p.Trp274Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	67	-0.9	1.9	-2.8	264	203	61	5.4	5.7	-0.3	204	149	55	5.89	5.74	-0.15	-1.254	-4.756	3.502	1.224	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274N	274	W	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	174	-0.9	-3.5	2.6	264	187	77	5.4	11.6	-6.2	204	132	72	5.89	5.47	-0.42	-1.254	-4.217	2.963	2.478	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274P	274	W	P	missense	low	0.422002971350273	0.328690543039087	6	0.134187352287346	0.159000593686286	0.68500534901426	0.174895596477107	0.26605079936851	0.200203631408879	0.605559156890751	1.01315558596906	NA	NA	0.272153057987335	0.430863175918156	0.390323933230087	0.43086846440829	0.392242143521449	0.561266182296163	0.758581141792928	NA	NA	0.430857887428023	p.Trp274Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	147	-0.9	-1.6	0.7	264	154	110	5.4	8	-2.6	204	115	89	5.89	6.3	0.41	-1.254	-4.316	3.062	1.182	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274Q	274	W	Q	missense	low	0.306283986741707	0.185547420935875	8	0.065600919787716	0.177708546605083	0.434859426878332	0.29488476574569	0.354057424416626	0.221193978957789	0.446841243892731	0.120791996647861	0.159434467335157	0.174845880845738	0.678222136092068	0.436330773837887	0.447411962485547	0.471438037442785	0.402536911162075	0.491660196933792	0.425249585190228	0.369922632993861	0.381758108466595	0.634805292899947	p.Trp274Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	130	-0.9	-3.5	2.6	264	214	50	5.4	10.5	-5.1	204	146	58	5.89	6.24	0.35	-1.254	-2.994	1.74	5.202	5.202	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.91	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
W274R	274	W	R	missense	low	0.255746048884424	0.144973910160574	7	0.0547949875539283	0.148349846745404	0.363142251023444	0.229900305197334	0.341093823148323	0.263315695793886	0.501180140456703	0.0775262062766447	0.0961950163572177	NA	0.281011154960861	0.423195610902108	0.416493882065882	0.46546203542979	0.423195610902108	0.515490603769386	0.409088175844679	0.338753634677283	NA	0.435306849421389	p.Trp274Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	101	-0.9	-4.5	3.6	264	265	-1	5.4	10.5	-5.1	204	174	30	5.89	6.34	0.45	-1.254	-4.24	2.986	1.764	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000392517663294848	0.000325978971769186	0.000325978971769186	0.000382466767223554	0.000361072281512583	0.000456052849407658	0.000203218398813205	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W274S	274	W	S	missense	low	0.315360067569249	0.206736666849235	7	0.0781391153373552	0.162210215724211	0.468509919414286	0.44301411432949	0.40773904541495	0.451648155004556	0.546210380406536	-0.0521988064729496	0.189272000571702	NA	0.221835583730456	0.496184361285006	0.517888428295685	0.496184361285006	0.515563729259546	0.535238684900286	0.36063097639415	0.384628738262629	NA	0.405586033751088	p.Trp274Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	177	-0.9	-0.8	-0.1	264	143	121	5.4	9.2	-3.8	204	105	99	5.89	5.68	-0.21	-1.254	-2.506	1.252	6.385	6.385	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	2	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
W274T	274	W	T	missense	low	0.412327816548404	0.097318524641759	2	0.0688145887092579	0.277453701067321	0.547201932029486	NA	NA	0.481142405257661	0.343513227839146	NA	NA	NA	NA	0.488187396582288	NA	NA	0.5300292569209	0.446345536243676	NA	NA	NA	NA	p.Trp274Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	128	-0.9	-0.7	-0.2	264	163	101	5.4	8.6	-3.2	204	119	85	5.89	5.6	-0.29	-1.254	-2.777	1.523	6.895	6.895	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274V	274	W	V	missense	low	0.495734499200076	0.0984845200954954	8	0.0348195360007138	0.427489462680281	0.563979535719871	0.612935728171629	0.4827864332727	0.569453744550617	0.62711086028341	0.424732500501073	0.360536251325349	0.407713769589084	0.480606705906743	0.537168093894194	0.5987331422085	0.530779944072989	0.573341770729213	0.57071771503464	0.538782860725447	0.46904021022959	0.507179214759582	0.535553327062941	p.Trp274Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	88	-0.9	4.2	-5.1	264	165	99	5.4	5.9	-0.5	204	117	87	5.89	5.61	-0.28	-1.254	-3.187	1.933	9.887	9.887	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
W274X	274	W	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	NA	-0.9	NA	NA	264	NA	NA	5.4	NA	NA	204	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	2	1	1	0	1	1	0.00234510552974884	0.00278893120291415	0.00278893120291415	0.00122867448970567	0.00285247102394941	0.00326881811136125	0.00506884749039793	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
W274Y	274	W	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Trp274Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.6	74.4	33.2	0.888	24.4	168.8	-109.6	143.1	9.84848484848485	-1	0	1	21.15	0	0	0	0	6	15.8464967062124	37	-0.9	-1.3	0.4	264	255	9	5.4	6.2	-0.8	204	181	23	5.89	5.66	-0.23	-1.254	-3.946	2.692	0.78	NA	64.27	0.002073809	0	0.059272923	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.255	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275A	275	V	A	missense	low	0.377577306904596	0.177167372508235	8	0.0626381252527879	0.254808837350023	0.50034577645917	0.569207683209983	0.178519732125553	0.43689166893173	0.613366605674773	0.312370781580635	0.47932738150623	0.123020661290524	0.307913940917343	0.502568941330959	0.577928365200113	0.390518115518545	0.50832637432972	0.564690150993287	0.496811508332198	0.527589114108023	0.353845387629177	0.448818721394994	p.Val275Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.247	-2.979	0.732	8.985	8.985	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
V275C	275	V	C	missense	possibly_low	0.694129775866705	0.35835515868495	8	0.126697681389655	0.445806883418251	0.942452668315159	0.644989050542304	1.11442500733436	0.877072147727104	0.78651577584359	0.893703255647422	-0.07047435595715	0.811670331230832	0.495136994565182	0.677293082124916	0.613983360343904	0.821954696516777	0.724213974026616	0.640624986429458	0.713961177820374	0.256606852806836	0.724747549873655	0.542851136308792	p.Val275Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.247	-5.051	2.804	1.461	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V275D	275	V	D	missense	low	0.186527282447665	0.247246967883643	3	0.14274810346394	-0.0932538592030553	0.466308424098384	NA	NA	NA	NA	-0.0632450580890854	0.191657882679608	0.431169022752471	NA	0.385804674395136	NA	NA	NA	NA	0.356504783562109	0.385804674395136	0.519812059141901	NA	p.Val275Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.247	-4.258	2.011	1.647	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275E	275	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.247	-4.137	1.89	1.626	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V275F	275	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.247	-1.332	-0.915	21.138	21.138	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.42	Neutral	TOLERATED	neutral	TOLERATED	null	NA	NA	NA	NA	NA	NA	0
V275G	275	V	G	missense	low	0.321532994718998	0.080629894240982	8	0.0285069724920763	0.265660355326254	0.377405634111741	0.332328242919567	0.317830342518743	0.292686737559379	0.397750156656395	0.474949809388379	0.233397251740701	0.273124565660259	0.250196851308557	0.446169336515502	0.465226689709332	0.454737962373672	0.437600710657332	0.470131224966791	0.55754092519616	0.406376869502492	0.434690358769436	0.419830425285271	p.Val275Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.247	-3.924	1.677	2.431	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V275H	275	V	H	missense	low	0.33393294611006	0.181290868726796	6	0.0740116872344229	0.188872704695548	0.478993187524572	NA	0.425388924029101	0.51310181859736	0.362460764061086	-0.00212649409668571	NA	0.283700904177768	0.421071759891731	0.479487832871166	NA	0.504320658286456	0.545703829888131	0.454655007455875	0.379334879183116	NA	0.440386704815915	0.505652016105348	p.Val275His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.247	-4.992	2.745	0.937	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V275I	275	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.247	-2.302	0.055	24.593	24.593	85.11	0.002147919	0	0.061391113	3.606e-05	1	27734	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.41	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V275K	275	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.247	-4.094	1.847	2.088	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275L	275	V	L	missense	possibly_wt-like	0.868758383676956	0.285048493004729	8	0.100779861185325	0.671233485386773	1.06628328196714	0.809124722703291	1.02579074656693	1.13099147534568	1.17109303953503	0.843237327076433	0.8845893357424	0.831364535927674	0.253875886518207	0.731343191020971	0.692075259065337	0.781095793978514	0.848749333491542	0.809281938134339	0.695110244493114	0.727331663640381	0.735354718401561	0.421678213570826	p.Val275Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.247	-1.75	-0.497	24.134	24.134	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V275M	275	V	M	missense	wt-like	0.865302611491168	0.1428048544987	5	0.0638642724352119	0.740130937619299	0.990474285363038	NA	0.721241212307946	0.832021781627567	1.10041351440988	0.873606034576701	NA	NA	0.799230514533745	0.702118911044014	NA	0.64070358411947	0.702118911044014	0.778285323458959	0.706454105520407	NA	NA	0.69558151584884	p.Val275Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.247	-3.524	1.277	4.421	4.421	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V275N	275	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.247	-4.394	2.147	1.326	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275P	275	V	P	missense	low	0.2690741774963	0.23185926693754	7	0.087634565640353	0.0973135850403964	0.440834769952203	NA	0.249281182576232	0.484928015717207	0.381335824676399	0.00295300660438415	0.0455401999687274	0.109005272289185	0.610475740641963	0.423137953292305	NA	0.423137953292305	0.531885918892225	0.462932694379088	0.381232264840391	0.313787259063266	0.346296791714298	0.600779797418706	p.Val275Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.247	-4.447	2.2	1.343	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275Q	275	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.247	-4.525	2.278	1.188	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275R	275	V	R	missense	low	0.232235664791515	0.0701999147318209	8	0.024819417872794	0.183590499643589	0.280880829939441	0.15636435150353	0.189761298678491	0.228787662660703	0.30983920722873	0.15880897949446	0.189652282723878	0.333127522485458	0.29154401355687	0.418919497319359	0.381507202006424	0.395700288508843	0.406261252032361	0.431577742606357	0.439450366375434	0.384816168949925	0.467007554869243	0.440596957185528	p.Val275Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.247	-4.384	2.137	1.658	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V275S	275	V	S	missense	low	0.22286302844781	0.138766767317864	8	0.0490614610868987	0.126704331688575	0.319021725207045	0.140567631246337	0.219084554677551	0.279703729348491	0.310190165990525	-0.0481805418062407	0.166337973545091	0.403326783528453	0.311873931052274	0.420225489169366	0.373991493433058	0.409217816026943	0.431233162311789	0.431731656112242	0.362131950248557	0.373325182669868	0.504816413052633	0.450807618745866	p.Val275Ser	0	0	NA	NA	NA	NA	NA	NA	NA	2.486	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.247	-3.25	1.003	5.293	5.293	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V275T	275	V	T	missense	low	0.493515679863971	0.266223636601053	8	0.094124269376374	0.309035501815132	0.67799585791281	0.254313019426846	0.683129731875785	0.695795810474279	0.723961119100667	0.705232177011664	0.406608658752118	-0.0129945880916852	0.492079510362093	0.577253533056895	0.428108878257913	0.623134833039651	0.635306548057937	0.613191545305202	0.643560100537475	0.491748041612039	0.280588472979881	0.541315520808587	p.Val275Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.247	-3.783	1.536	3.594	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V275V	275	V	V	synonymous	possibly_wt-like	0.856951262117638	0.294665110347451	8	0.104179848852882	0.652762510451162	1.06114001378411	0.991536580638845	0.9252681665081	0.861163365421662	1.01488756230427	0.878560131178659	0.152086882535571	1.09390855537614	0.938198852977859	0.737767180835984	0.778862537832624	0.734756576322082	0.716411472572164	0.740777785349886	0.708304648002925	0.366301209108807	0.87675919261881	0.765378093812137	p.Val275=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V275W	275	V	W	missense	low	0.460427861145824	0.0987973540468704	5	0.0441835199291832	0.373829753374417	0.54702596891723	0.349867805478552	0.381072420073198	NA	NA	0.506239471886172	0.595887958475143	NA	0.469071649816052	0.529759867554402	0.473571601725966	0.483891495790002	NA	NA	0.569228797752566	0.585038639224722	NA	0.529759867554402	p.Val275Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.247	-5.124	2.877	0.982	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V275X	275	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V275Y	275	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val275Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.5	73.7	36.8	0.961	26.8	-133.6	-146.7	159.9	3.63636363636364	-6.7	0	1	24.22	0	0	0	0	5	18.6466462898828	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.247	-3.792	1.545	4.903	NA	85.11	0.002147919	0	0.061391113	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N276A	276	N	A	missense	low	0.215742176927576	0.146625251284481	5	0.0655728058180174	0.0872218391590235	0.344262514696129	0.290707345022562	0.427481453919135	0.154712461166147	0.0465426286902682	NA	NA	NA	0.159266995839768	0.374161082055907	0.445424443796085	0.505285279349407	0.36993088706141	0.316108622293901	NA	NA	NA	0.374161082055907	p.Asn276Ala	0	0	NA	NA	NA	NA	NA	NA	NA	0.635	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.132	-3.018	1.886	8.985	8.985	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276C	276	N	C	missense	low	0.398709083080625	0.11346699186749	3	0.0655101982988326	0.270311453794836	0.527106712366414	NA	0.459886789503081	0.267782179155209	0.468458280583584	NA	NA	NA	NA	0.501140381690885	NA	0.5202235936861	0.425386208664646	0.501140381690885	NA	NA	NA	NA	p.Asn276Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.132	-5.332	4.2	0.689	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276D	276	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.132	-3.538	2.406	1.219	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N276E	276	N	E	missense	low	0.340294369962927	0.104156353989617	3	0.0601346990137154	0.222432525674888	0.458156214250965	NA	0.266319975759955	0.295157345131186	0.45940578899764	NA	NA	NA	NA	0.438812426224387	NA	0.430992550194626	0.438812426224387	0.497170397554109	NA	NA	NA	NA	p.Asn276Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.132	-3.547	2.415	1.747	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276F	276	N	F	missense	low	0.241545570393202	0.210035135424114	3	0.121263841976392	0.00387280749251806	0.479218333293886	NA	0.0559919280373168	0.199073944374979	0.46957083876731	NA	NA	NA	NA	0.391688085734005	NA	0.334034859922774	0.391688085734005	0.50162829579704	NA	NA	NA	NA	p.Asn276Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.132	-4.248	3.116	8.44	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276G	276	N	G	missense	low	0.186351571057434	0.17475651673958	8	0.0617857590215486	0.0652537086177279	0.30744943349714	0.378123837041224	0.226077992505664	0.298011557089116	0.251820693308122	-0.186903885660196	0.0729258483467059	0.183912999780028	0.266843526048806	0.409287653538594	0.487015158059641	0.412441673169229	0.440212281507179	0.40613363390796	0.310313533745094	0.327284897246263	0.386641598817135	0.428191185328499	p.Asn276Gly	0	0	NA	NA	NA	NA	NA	NA	NA	4.364	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.132	-3.391	2.259	2.431	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276H	276	N	H	missense	low	0.177747343273444	0.182398038089933	5	0.0815708824263372	0.0178713515306723	0.337623335016217	0.389955049144882	NA	NA	NA	-0.00320784748579523	0.0695115593970827	0.0737239101079913	0.358754045203061	0.378930952787258	0.492644170968209	NA	NA	NA	0.378930952787258	0.325602087467282	0.327294483151412	0.474353064988426	p.Asn276His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.132	-1.635	0.503	11.86	11.86	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.315	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N276I	276	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.132	-4.247	3.115	2.752	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N276K	276	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.132	-3.612	2.48	3.057	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N276L	276	N	L	missense	low	0.267299068965543	0.0786362965099533	4	0.0393181482549767	0.190236914446982	0.344361223484103	NA	0.258628598544918	0.169708122716643	0.361087416207564	NA	NA	NA	0.279772138393046	0.431065755249318	NA	0.427446954740981	0.37728554619319	0.4540527236381	NA	NA	NA	0.434684555757656	p.Asn276Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.132	-3.811	2.679	4.399	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276M	276	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.132	-4.966	3.834	1.138	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276P	276	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.132	-4.183	3.051	0.901	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276Q	276	N	Q	missense	low	0.334495127533528	0.179335673690229	8	0.0634047354875093	0.210224129528722	0.458766125538335	0.280222731017269	0.0713831981303567	0.182344437868067	0.402909846753084	0.633860227665474	0.416431729365165	0.463978130408556	0.224830719060255	0.456415062826951	0.44043611064306	0.341129976407378	0.383483058074045	0.472394015010842	0.616899977625656	0.496589564848989	0.537482827752026	0.407090334650828	p.Asn276Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.132	-3.985	2.853	1.346	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276R	276	N	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.132	-3.164	2.032	8.708	8.708	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276S	276	N	S	missense	low	0.340315933801628	0.108964750515345	5	0.0487305178607235	0.244805873846624	0.435825993756632	NA	0.405368825664015	0.351386616803229	0.385668100309743	0.14976313373576	0.409392992495394	NA	NA	0.466390210971232	NA	0.495091729869578	0.466390210971232	0.464832620535023	0.436071400801739	0.493120363673898	NA	NA	p.Asn276Ser	1	0	yes	NA	NA	NA	NA	NA	NA	3.553	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.132	-3.418	2.286	2.613	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	3	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N276T	276	N	T	missense	low	0.394186430110137	0.329424996025916	8	0.116469324291138	0.16591074919579	0.622462111024484	0.89327076564104	0.170859245430584	0.428316102978003	0.555463624633084	-0.0290631691838243	0.542500161969112	-0.0303633148128895	0.622508024225989	0.5217085881544	0.732109970450068	0.386986760074777	0.5041204668918	0.539296709417	0.369273012087746	0.558725252348502	0.27123379152496	0.606822988469643	p.Asn276Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.132	-3.66	2.528	1.875	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N276V	276	N	V	missense	low	0.082446217863398	0.185390312802277	2	0.131090747348785	-0.174486925646661	0.339379361373457	NA	NA	NA	NA	NA	NA	-0.0486445294853874	0.213536965212183	0.331402859406584	NA	NA	NA	NA	NA	NA	0.261387650088382	0.401418068724786	p.Asn276Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.132	-3.977	2.845	3.084	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276W	276	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.132	-5.497	4.365	1.767	NA	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N276X	276	N	X	nonsense	low	0.0022750855877171	0.146175219455835	5	0.0653715454658393	-0.125850789139051	0.130400960314485	0.23937629208162	NA	NA	NA	-0.133494899501339	-0.0785568538709897	-0.0531098821432768	0.0371607713725713	0.312833468073849	0.421002334118447	NA	NA	NA	0.330263810410289	0.252623210318256	0.258982640649927	0.312833468073849	p.Asn276Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N276Y	276	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn276Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	41.6	74.1	39	0.985	15.4	-136.2	-120.7	128.2	0	-2.2	0	1	21.62	1	2	0	0	6	20.5949604966846	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.132	-2.819	1.687	20.399	20.399	64.27	0.001458624	0	0.041689902	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T277A	277	T	A	missense	low	0.289197528635449	0.119865239710001	6	0.0489347791976492	0.193287123816637	0.385107933454262	NA	0.313266220875633	0.387423698148911	0.45808697375244	0.135807044032158	NA	0.225994560070878	0.214606674932676	0.441746126240065	NA	0.452633979108353	0.484064686252581	0.49659202909576	0.430858273371778	NA	0.409306449152212	0.401955328353421	p.Thr277Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-0.977	-2.42	1.443	9.775	9.775	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T277C	277	T	C	missense	low	0.0760804571139704	0.11770166277836	3	0.0679550866891525	-0.0571090653630657	0.209269979591007	0.206759517750852	NA	NA	NA	-0.0215997403912716	0.0430815939823313	NA	NA	0.372060885065517	0.405484038770925	NA	NA	NA	0.372060885065517	0.312575479317142	NA	NA	p.Thr277Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-0.977	-3.184	2.207	16.07	16.07	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.645	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T277D	277	T	D	missense	low	0.218778496409583	0.118438924528776	6	0.0483524884632514	0.124009360458722	0.313547632360445	0.249877853979381	0.176238521380598	0.250567560078754	0.399890914069086	0.0366337461211478	NA	NA	0.199462382828534	0.405646196710219	0.425998730680752	0.389466515756892	0.416943256350443	0.471070057429476	0.393813295112136	NA	NA	0.394349137069996	p.Thr277Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-0.977	-3.078	2.101	9.549	9.549	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277E	277	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-0.977	-3.714	2.737	2.206	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277F	277	T	F	missense	low	0.193396235499868	0.114150655961573	3	0.0659049119475864	0.0642249816783156	0.322567489321421	NA	0.288206332120458	0.066690137760495	0.225292236618652	NA	NA	NA	NA	0.394499538340961	NA	0.441081792139093	0.32676012180668	0.394499538340961	NA	NA	NA	NA	p.Thr277Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-0.977	-4.287	3.31	2.069	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277G	277	T	G	missense	low	0.215504011067514	0.150656532027576	8	0.0532651277133737	0.111106279117376	0.319901743017653	0.246556925845135	0.479507244477576	0.308104770814632	0.236925411975488	0.120852186862907	0.0112298229564875	0.0545215583657889	0.266334167242102	0.424845389783029	0.424418711053657	0.529268293225738	0.44516252303173	0.399601285322828	0.425272068512401	0.296876611250895	0.316952223375147	0.427935360857534	p.Thr277Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-0.977	-3.578	2.601	2.645	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277H	277	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-0.977	-4.951	3.974	0.65	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T277I	277	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-0.977	-3.103	2.126	10.848	10.848	42.43	0.001420907	0	0.040611881	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 31, 2014)	criteria provided, single submitter	0	0	1	0	0	5	7	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
T277K	277	T	K	missense	low	0.259528301347855	0.0656673298605869	5	0.0293673226938348	0.201969406545573	0.317087196150137	0.350693726463643	0.189484134623889	0.253196512800026	0.296190444777213	NA	NA	NA	0.208076688074506	0.418232632685952	0.473964555537105	0.39557252054422	0.418232632685952	0.425592056797682	NA	NA	NA	0.398675655141894	p.Thr277Lys	1	0	NA	NA	NA	NA	NA	NA	NA	9.351	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-0.977	-3.755	2.778	1.721	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	not specified	Uncertain significance(Last reviewed: Apr 17, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T277L	277	T	L	missense	low	0.204932029895576	0.162211030533015	6	0.0662223759094848	0.0751385581423127	0.334725501648839	NA	0.222118611230647	0.352923735695718	0.357418009105534	-0.0762017878904482	NA	0.243278352029957	0.130055259202047	0.414615925170756	NA	0.410616465036087	0.467144094716955	0.452443499498191	0.351664954859042	NA	0.418615385305426	0.35948954408902	p.Thr277Leu	0	0	NA	NA	NA	NA	NA	NA	NA	3.42	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-0.977	-3.333	2.356	8.37	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277M	277	T	M	missense	low	0.194729714827446	0.18727461026055	4	0.0936373051302748	0.0112039691627199	0.378255460492172	0.224268489201359	NA	NA	NA	-0.0616786589738931	NA	0.227969009599854	0.388360019482464	0.412092135439785	0.413814396256459	NA	NA	NA	0.357089892884785	NA	0.41036987462311	0.48922260804483	p.Thr277Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-0.977	-3.505	2.528	6.873	6.873	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277N	277	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-0.977	-3.81	2.833	1.746	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277P	277	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-0.977	-3.978	3.001	1	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T277Q	277	T	Q	missense	low	0.214324896346377	0.303971322061905	7	0.114890360553046	-0.0108560725084148	0.439505865201169	NA	0.0652862222958476	0.479539073087869	0.689243214780148	-0.154000788064292	-0.058583528929999	0.127831045375855	0.350959035879209	0.356436228714791	NA	0.338319373157083	0.529242898710285	0.597965954857977	0.322604085343055	0.262467516709837	0.356436228714791	0.470438036701492	p.Thr277Gln	0	0	NA	NA	NA	NA	NA	NA	NA	4.352	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-0.977	-4.176	3.199	1.256	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277R	277	T	R	missense	low	0.212413414092347	0.132693431597693	8	0.0469142126508211	0.120463246933684	0.30436358125101	0.0512490294964815	0.218436746088125	0.295740630240054	0.447268462385669	0.139569238342087	0.114132269405844	0.116095775967447	0.316815160813069	0.420591391215473	0.331495800023106	0.40891918716955	0.439098499842275	0.491847554262302	0.432263595261395	0.347594416838274	0.35011569014766	0.453289341792247	p.Thr277Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-0.977	-4.038	3.061	1.364	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Apr 15, 2016)	criteria provided, single submitter	0	1	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
T277S	277	T	S	missense	low	0.476600474359402	0.198295951246487	6	0.080953983102284	0.317933583073861	0.635267365644943	NA	0.669856656916162	0.616456762808346	0.606218285969682	0.377823284434965	NA	0.141473592211282	0.447774263815975	0.541407869215156	NA	0.617016168863263	0.596394516770883	0.561555244369582	0.521260494060731	NA	0.363784014302519	0.519063296817417	p.Thr277Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-0.977	-2.664	1.687	6.985	6.985	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
T277V	277	T	V	missense	low	0.312113038949306	0.0825228859277678	5	0.0369053565267899	0.239779869320188	0.384446208578425	0.228518622590637	0.248813746585995	0.283412169142025	0.398359197139868	NA	NA	NA	0.401461459288007	0.433051975739948	0.415836509925099	0.422922473167547	0.433051975739948	0.470398320609476	NA	NA	NA	0.495802780730616	p.Thr277Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-0.977	-2.861	1.884	15.766	15.766	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
T277W	277	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr277Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-0.977	-5.417	4.44	0.337	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T277X	277	T	X	nonsense	low	-0.0104981229071092	0.0336388374356739	5	0.0150437454380463	-0.0399833221582688	0.0189870763440503	-0.0323007859109669	-0.0497819539285632	NA	NA	0.0365422743756114	NA	0.0064311015414008	-0.0133812506130282	0.291051021068557	0.29174475969719	0.285274880464288	NA	NA	0.393779126955019	NA	0.291051021068557	0.287448835736468	p.Thr277Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T277Y	277	T	Y	missense	low	0.108812984748405	0.217901539225229	8	0.0770398280085729	-0.0421823035235579	0.259808273020368	0.114921442278895	0.153420860042445	0.190731712838077	0.441508475039618	-0.348369550675429	0.0941101638899651	0.0691375285873353	0.155043245986334	0.366914675411512	0.361789638924113	0.378947957891181	0.387596617735365	0.489321502934361	0.25	0.337726067833529	0.324824288367123	0.372039711898911	p.Thr277Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	71.3	41.2	0.682	95.9	70.6	-54	-26.8	0.613496932515337	-3.8	0	0	25.48	2	86	0	0	8	24.3587203658156	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-0.977	-4.407	3.43	1.244	NA	42.43	0.001420907	0	0.040611881	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.195	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278A	278	F	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-2.074	-2.24	0.166	10.35	10.35	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F278C	278	F	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-2.074	-3.771	1.697	13.312	13.312	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F278D	278	F	D	missense	low	0.35143960427511	0.137661201082883	3	0.0794787315021699	0.195664152993928	0.507215055556292	NA	0.299441838351436	0.247350899290239	0.507526075183653	NA	NA	NA	NA	0.446261171422959	NA	0.446261171422959	0.41536563714622	0.518273623224286	NA	NA	NA	NA	p.Phe278Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-2.074	-3.041	0.967	13.191	13.191	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278E	278	F	E	missense	low	0.384785508693865	0.160806023746382	5	0.0719146400576713	0.243835404219668	0.525735613168062	0.570130563528297	0.483235668211189	0.42426420112443	0.170339894683712	NA	NA	NA	0.275957215921698	0.502133201650576	0.578367449985285	0.530987033819206	0.502133201650576	0.370400104092484	NA	NA	NA	0.432768518358947	p.Phe278Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-2.074	-3.463	1.389	9.435	9.435	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278G	278	F	G	missense	low	0.401832957685772	0.137190686016218	8	0.0485042321988511	0.306766409478256	0.496899505893288	0.484073806008126	0.38097354374484	0.45597961241559	0.38611742723464	0.388450936281496	0.480529209132028	0.0941408520975948	0.544398274571859	0.521459213628239	0.537423665467994	0.483845915466674	0.517688103212286	0.465029673550442	0.525230324044191	0.528181462122847	0.338290913209994	0.567592518475785	p.Phe278Gly	0	0	NA	NA	NA	NA	NA	NA	NA	5.79	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-2.074	-2.88	0.806	42.509	42.509	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.505	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F278H	278	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-2.074	-4.923	2.849	2.421	NA	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F278I	278	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-2.074	-4.054	1.98	6.559	NA	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F278K	278	F	K	missense	low	0.235029793252169	0.12606903434625	5	0.0563797861311941	0.124527442978958	0.34553214352538	0.356887924666032	NA	NA	NA	0.185251182448528	0.166696263180618	0.0889870996336868	0.377326496331979	0.449327529424398	0.476911609594965	NA	NA	NA	0.449327529424398	0.373501773846324	0.335515136184352	0.483681042481014	p.Phe278Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-2.074	-3.963	1.889	3.656	NA	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278L	278	F	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-2.074	-3.116	1.042	11.088	11.088	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	1	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	deleterious	deleterious	medium	3.055	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F278M	278	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-2.074	-2.994	0.92	5.024	5.024	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278N	278	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-2.074	-3.086	1.012	9.902	9.902	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278P	278	F	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-2.074	-4.368	2.294	1.534	NA	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F278Q	278	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-2.074	-3.508	1.434	6.37	6.37	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278R	278	F	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-2.074	-3.475	1.401	10.415	10.415	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F278S	278	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-2.074	-1.954	-0.12	7.749	7.749	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	1.955	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F278T	278	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-2.074	-2.966	0.892	9.153	9.153	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F278V	278	F	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-2.074	-3.393	1.319	10.756	10.756	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.36	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F278W	278	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-2.074	-3.551	1.477	15.401	15.401	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.055	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F278X	278	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F278Y	278	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe278Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	43.6	73.6	44.3	0.849	98.8	48.6	-59.5	-39.5	15.3508771929825	-0.6	0	0	28.48	0	0	0	0	6	25.3911846486138	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-2.074	-2.744	0.67	16.303	16.303	39.95	0.001585999	0	0.045330507	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.36	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F279A	279	F	A	missense	low	0.378180290204096	0.272639348496824	5	0.121928023316031	0.139205755798516	0.617154824609676	NA	0.302654964914901	0.537524315458138	0.659223106671139	-0.0498998487119361	NA	NA	0.441398912688238	0.515861289101037	NA	0.447742368693213	0.557681903609863	0.584800590179583	0.36148972408199	NA	NA	0.515861289101037	p.Phe279Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.131	-2.731	1.6	7.044	7.044	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.955	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F279C	279	F	C	missense	possibly_wt-like	0.892724492238593	0.232111212828763	4	0.116055606414382	0.66525968346245	1.12018930101474	NA	0.83219452837902	0.98643787292918	1.14874074550151	0.603524822144664	NA	NA	NA	0.734851929389931	NA	0.691851195532859	0.777852663247004	0.799479305136438	0.605568556147425	NA	NA	NA	p.Phe279Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.131	-5.023	3.892	1.345	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F279D	279	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.131	-4.15	3.019	1.516	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279E	279	F	E	missense	low	0.232617395861367	0.123555095659356	7	0.0466994366184931	0.14108818199081	0.324146609731924	NA	0.305315183703418	0.18751703302812	0.33852359039608	0.115718110284475	0.0523792928428456	0.232212583373858	0.396655977400771	0.423354296700456	NA	0.448968684784411	0.386019970106954	0.444157323052958	0.423354296700456	0.31715806116518	0.412655435420022	0.493389236789968	p.Phe279Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.131	-4.05	2.919	1.497	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279G	279	F	G	missense	low	0.421056153770478	0.146667820753524	8	0.051854905318335	0.319422406924807	0.522689900616149	0.347850393836064	0.292073172056691	0.32551411786858	0.436672579275018	0.481008559980721	0.298222385204155	0.736765138497393	0.450342883445204	0.479906239015639	0.472611764637596	0.442864340272486	0.45370098016198	0.487200713393681	0.559804097730518	0.438327407411164	0.684404107974409	0.520353381035281	p.Phe279Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.131	-3.798	2.667	1.906	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279H	279	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.131	-4.861	3.73	0.713	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F279I	279	F	I	missense	possibly_low	0.571408874325938	0.214101077754103	3	0.12361131487512	0.329135149089062	0.813682599562814	NA	0.326514083941332	0.72316800313003	0.66454453590645	NA	NA	NA	NA	0.58713431117215	NA	0.458741021025948	0.648731307345452	0.58713431117215	NA	NA	NA	NA	p.Phe279Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.131	-2.811	1.68	22.639	22.639	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F279K	279	F	K	missense	low	0.295214926527851	0.156670288055235	3	0.090453632982706	0.117929063610943	0.472500789444759	NA	0.162701924627558	0.254813997334384	0.468128857621612	NA	NA	NA	NA	0.419025931958617	NA	0.383226372468694	0.419025931958617	0.500995912743203	NA	NA	NA	NA	p.Phe279Lys	0	0	NA	NA	NA	NA	NA	NA	NA	11.4955	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.131	-4.013	2.882	1.922	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279L	279	F	L	missense	low	0.510255678453617	0.164794294113839	3	0.0951440300675395	0.323776806177244	0.69673455072999	NA	NA	0.45502763538	0.695570545949389	NA	NA	NA	0.380168854031463	0.517221203731095	NA	NA	0.517221203731095	0.600740815693971	NA	NA	NA	0.485108611112781	p.Phe279Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.131	-2.324	1.193	13.973	11.182	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F279M	279	F	M	missense	possibly_wt-like	1.18648427706192	0.429102212516615	3	0.247742277906332	0.700918334917599	1.67205021920625	1.07786286870826	NA	NA	NA	1.65945922740996	NA	0.822130735067544	NA	0.819934558656362	0.819934558656362	NA	NA	NA	1	NA	0.73038145426705	NA	p.Phe279Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.131	-2.614	1.483	4.903	4.903	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279N	279	F	N	missense	low	0.19304377406744	0.202726415196801	2	0.143349222911298	-0.0879155400505073	0.474003088185387	NA	0.0496945511561423	NA	NA	NA	NA	NA	0.336392996978738	0.397127073564336	NA	0.331131875162628	NA	NA	NA	NA	NA	0.463122271966045	p.Phe279Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.131	-4.277	3.146	1.296	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279P	279	F	P	missense	possibly_low	0.263313352790418	0.334973486227832	2	0.236862023629398	-0.200927682828478	0.727554388409314	0.500175376419816	0.0264513291610199	NA	NA	NA	NA	NA	NA	0.432750777791346	0.545084414586641	0.320417140996052	NA	NA	NA	NA	NA	NA	p.Phe279Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.131	-4.383	3.252	1.236	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F279Q	279	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.131	-4.417	3.286	1.094	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F279R	279	F	R	missense	low	0.215082516355914	0.191458641987495	8	0.0676908520330625	0.0824108842882819	0.347754148423547	0.270653837957586	0.204572534696356	0.350070315807287	0.140327134500694	-0.0281810856054971	0.0900059832072324	0.101485164422347	0.59172624586131	0.386065261358941	0.435883456013784	0.402528019046508	0.465744627906599	0.357237961858358	0.369602503671375	0.335703229260252	0.342246511303413	0.591362900096037	p.Phe279Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.131	-4.286	3.155	1.527	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F279S	279	F	S	missense	low	0.300651603216673	0.19458333621785	6	0.0794383143636924	0.144955368071265	0.456347838362081	NA	0.396341808266226	0.341944630220042	0.409998951988953	-0.0925720469871249	NA	0.397348681641118	0.350847594170824	0.4729425091789	NA	0.490930426769919	0.461759365402176	0.475502953037808	0.345550043838484	NA	0.501596646874102	0.470382065319991	p.Phe279Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.131	-3.118	1.987	5.184	5.184	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F279T	279	F	T	missense	low	0.345399686420217	0.230852481656651	8	0.0816186776165805	0.185430017825933	0.5053693550145	0.224576506140269	0.345954176155994	0.400024045940765	0.405200897288031	-0.0952120449116333	0.32403896166806	0.734018235555064	0.424596713525183	0.470550667561327	0.413960943483404	0.467702576368728	0.49024455785337	0.473398758753926	0.34456390474884	0.451051692899095	0.682924644198765	0.507422417218643	p.Phe279Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.131	-3.104	1.973	5.675	5.675	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F279V	279	F	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.131	-2.896	1.765	14.698	14.697	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.955	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
F279W	279	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.131	-4.962	3.831	0.444	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F279X	279	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe279Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F279Y	279	F	Y	missense	possibly_low	0.638464031576684	0.202177636812089	4	0.101088818406044	0.440333588261127	0.836594474892241	NA	0.737756600184516	0.612863978162074	0.835495648272875	NA	NA	NA	0.367739899687271	0.621474663339177	NA	0.648316899983874	0.59463242669448	0.662105184971422	NA	NA	NA	0.478866192943296	p.Phe279Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	2.166	39.9	74.1	44.9	0.402	93.2	75.6	-87.3	3.2	13.1578947368421	-2	0	0	29.52	0	0	0	0	5	24.6013824379851	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.131	-3.648	2.517	1.697	NA	83.37	0.000871735	0	0.024915644	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.3	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
I280A	280	I	A	missense	low	0.365546713423661	0.235366555847874	8	0.083214643852277	0.202449008486871	0.528644418360452	0.499816275346038	0.400198148869314	0.490037012480616	0.408631760024835	0.0855327001649814	-0.078598654509984	0.545513796232788	0.573242668780701	0.513549886911165	0.54491356272784	0.492708134887431	0.534391638934899	0.474903368894819	0.412078904178586	0.252602607924872	0.581397398649696	0.582079559421526	p.Ile280Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.565	-2.825	1.26	8.194	8.194	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280C	280	I	C	missense	low	0.50914384576992	0.181366952293389	8	0.0641229009248964	0.383465269372893	0.634822422166947	0.473726078411935	0.594910167680489	0.739972851511125	0.742220466437896	0.284127472127422	0.549784817527864	0.404812694292632	0.28359621817	0.547408059891759	0.532500459654171	0.582467098641979	0.656973286613123	0.62119921022137	0.48626156387423	0.562315660129347	0.505616714772641	0.436605192395313	p.Ile280Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.565	-3.774	2.209	14.391	14.391	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
I280D	280	I	D	missense	low	0.279036967353231	0.108938075890276	5	0.0487185886057377	0.183550288308362	0.3745236463981	NA	0.368371681438393	0.298245822320838	0.224506302476747	0.3837272425293	NA	0.120333788000876	NA	0.440327177466917	NA	0.478036669027187	0.440327177466917	0.394154865711742	0.523465845741651	NA	0.352398255427845	NA	p.Ile280Asp	0	0	NA	NA	NA	NA	NA	NA	NA	9.837	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.565	-4.176	2.611	3.054	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280E	280	I	E	missense	possibly_low	0.50257030294533	0.380111254507344	8	0.134389622833734	0.239171482295289	0.76596912359537	1.02942779222853	0.188114246891404	0.375446085609143	0.438926258918996	0.193751121510026	0.35495257255395	0.271066850415063	1.16887749543552	0.472239202071543	0.796890286578137	0.394941025354151	0.47819023668956	0.488189068074934	0.452502578196337	0.466288167453527	0.433582086933928	0.881235993769967	p.Ile280Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.565	-3.176	1.611	10.025	10.025	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280F	280	I	F	missense	low	0.481621282854921	0.104898457492688	4	0.052449228746344	0.378822683495184	0.584419882214658	NA	NA	NA	NA	0.4292361290712	0.363167465446004	0.538382690024145	0.595698846878335	0.559010884159839	NA	NA	NA	NA	0.540465136357942	0.47033706381116	0.577556631961737	0.593358131237937	p.Ile280Phe	0	0	NA	NA	NA	NA	NA	NA	NA	0.654	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.565	-4.133	2.568	4.565	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280G	280	I	G	missense	low	0.272548183474572	0.15920667105954	8	0.0562880583581683	0.162225616332873	0.382870750616271	0.302177547831644	0.382064741434577	0.308432362849131	0.325756510027868	0.15330608121262	0.00674119804124934	0.173091278858388	0.528815747541099	0.441940745816231	0.450881696959203	0.484348939237267	0.445323191351691	0.43855830028077	0.437394825705619	0.294664290614595	0.38081309142906	0.559766224551971	p.Ile280Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.565	-3.972	2.407	2.217	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280H	280	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.565	-3.818	2.253	9.136	9.136	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280I	280	I	I	synonymous	possibly_wt-like	1.06580396777222	0.600052264542327	6	0.244970311188375	0.585670980561438	1.545936954983	NA	1.2252004555513	1.24287049293741	1.32600518152719	1.65945922740996	-0.0838791416981843	1.02516759090565	NA	0.875119605299731	NA	0.873020313842851	0.903620673153002	0.877218896756611	1	0.25	0.839735763334244	NA	p.Ile280=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	NA	NA	NA	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
I280K	280	I	K	missense	low	0.14144743857321	0.146303622177083	6	0.0597282036424652	0.0243823105727043	0.258512566573716	NA	0.273550323472699	0.249102301337582	0.0193064724506676	-0.095160710192167	NA	0.200020292125564	0.201865952244915	0.395436602595457	NA	0.434325618806638	0.416224616592878	0.304164163998481	0.344583080208431	NA	0.395316880051759	0.395556325139155	p.Ile280Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.565	-4.027	2.462	2.568	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I280L	280	I	L	missense	wt-like	0.823196190938393	0.0870024472780193	8	0.0307600102250563	0.762907678733199	0.883484703143587	0.826040893944955	0.815115804687188	0.760464888131469	0.99355329487749	0.900686239335111	0.776650780334391	0.794578617631547	0.718479008564994	0.69205088373472	0.700123576131128	0.683978191338312	0.667023656431825	0.731421609489357	0.716569586377383	0.674131697483501	0.715542065855943	0.655024228878987	p.Ile280Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.565	-2.161	0.596	31.309	31.309	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.69	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I280M	280	I	M	missense	possibly_low	0.704314999732688	0.491766012800814	4	0.245883006400407	0.222393162777459	1.18623683668792	NA	0.859691285161504	0.901306846610293	1.07606898021229	-0.0198071130533361	NA	NA	NA	0.720313339709556	NA	0.704526737651294	0.736099941767818	0.767608990466649	0.372730499187063	NA	NA	NA	p.Ile280Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.565	-2.66	1.095	5.587	5.587	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.04	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
I280N	280	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.565	-4.332	2.767	1.408	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280P	280	I	P	missense	low	0.392039983918753	0.126556325431277	8	0.0447444179572538	0.304342536213328	0.479737431624177	0.596373566959807	0.361384467390381	0.370399720637451	0.40867773734266	0.422465319171675	0.136062000340216	0.437949991915858	0.403007067591974	0.486147147030733	0.590853254802348	0.474815680942784	0.475715234563353	0.474923532318412	0.537935982736842	0.358402982314513	0.52346424433068	0.496579059498114	p.Ile280Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.565	-4.312	2.747	1.28	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280Q	280	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.565	-4.411	2.846	2.199	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280R	280	I	R	missense	low	0.30738638085683	0.190926524997813	8	0.0675027202671683	0.175083480274698	0.439689281438962	0.37772100865871	0.211074083197279	0.396165804406278	0.541822030637811	0.102828836798666	0.0821959644042337	0.177718650523849	0.569564668227814	0.452681583628535	0.48682350177411	0.40552512348724	0.488352273792499	0.533314167345858	0.41853966548296	0.331853884283997	0.383305363234515	0.58023229079032	p.Ile280Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.565	-4.338	2.773	2.039	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I280S	280	I	S	missense	low	0.338615288382443	0.18188665171716	3	0.105012307330902	0.132794948080424	0.544435628684462	NA	0.132056194591228	0.408989521847031	0.474800148709069	NA	NA	NA	NA	0.494641697587602	NA	0.369099206676067	0.494641697587602	0.503921617731445	NA	NA	NA	NA	p.Ile280Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.565	-3.831	2.266	2.865	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280T	280	I	T	missense	possibly_low	0.594989280275728	0.145655557992382	3	0.0840942756158669	0.430167528762644	0.759811031788812	NA	0.585870345492665	0.454107435292168	0.74499006004235	NA	NA	NA	NA	0.578299892749612	NA	0.578299892749612	0.516769889332177	0.622413819765119	NA	NA	NA	NA	p.Ile280Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.565	-2.724	1.159	7.628	7.628	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
I280V	280	I	V	missense	wt-like	1.01241303854255	0.12581246787886	8	0.0444814245974784	0.925231048350461	1.09959502873464	0.970765354049484	0.975246212936538	0.839670551371847	0.891595127921548	1.21618496257081	1.10187872387811	1.12474892178729	0.979214453824794	0.77747908779814	0.768980075953493	0.757795614617112	0.705870268998928	0.686707698232233	0.834420294071897	0.834427668875701	0.893369610202106	0.785978099642787	p.Ile280Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.565	-1.634	0.069	20.175	20.175	83.37	0.001971497	0	0.05634868	4.083e-06	1	244926	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.595	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
I280W	280	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.565	-5.587	4.022	0.617	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
I280X	280	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I280Y	280	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile280Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.8	70.4	44.7	0.957	360	360	-78.7	-48.3	10.4712041884817	-1.6	0	0	35.75	0	0	0	0	5	26.5029435697245	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.565	-4.325	2.76	1.863	NA	83.37	0.001971497	0	0.05634868	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.04	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P281A	281	P	A	missense	wt-like	1.37079633102145	0.408230983026533	2	0.288662896388512	0.805027450426947	1.93656521161595	NA	NA	NA	NA	1.65945922740996	NA	NA	1.08213343463294	0.918834478889279	NA	NA	NA	NA	1	NA	NA	0.837668957778559	p.Pro281Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.131	-2.746	0.615	14.447	14.447	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	PTEN hamartoma tumor syndrome|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Aug 9, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
P281C	281	P	C	missense	wt-like	1.05881155040634	0.196266799634986	6	0.0801255854257966	0.901768288731592	1.21585481208109	NA	1.04425581255662	0.761213288698684	0.975931603497661	1.35482501535586	NA	1.15539143854028	1.06125214378893	0.808394624333035	NA	0.789607878640845	0.667390711332828	0.723693589576067	0.88620759821042	NA	0.909873467266735	0.827181370025225	p.Pro281Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.131	-3.576	1.445	13.671	13.671	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P281D	281	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.131	-3.083	0.952	10.533	10.533	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.835	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
P281E	281	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.131	-2.491	0.36	9.951	9.951	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.6	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
P281F	281	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.131	-4.491	2.36	6.745	NA	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P281G	281	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.131	-2.839	0.708	26.062	26.062	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P281H	281	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.131	-3.78	1.649	8.258	8.258	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
P281I	281	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.131	-4.064	1.933	7.904	NA	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P281K	281	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.131	-2.902	0.771	8.457	8.457	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P281L	281	P	L	missense	wt-like	1.11099226499343	0.201158969253433	3	0.116139185048377	0.883363645104781	1.33862088488208	NA	0.924156279992794	1.08489386973569	1.32392664525181	NA	NA	NA	NA	0.826140649312385	NA	0.734244015351086	0.826140649312385	0.87630735146959	NA	NA	NA	NA	p.Pro281Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.131	-2.766	0.635	13.138	13.138	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P281M	281	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.131	-3.811	1.68	6.31	6.31	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P281N	281	P	N	missense	wt-like	1.37723285811974	0.114762564531407	2	0.0811493876065166	1.21818298104349	1.53628273519599	NA	1.45838224572626	1.29608347051322	NA	NA	NA	NA	NA	0.95511615190002	NA	0.980513194766815	0.929719109033225	NA	NA	NA	NA	NA	p.Pro281Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.131	-3.178	1.047	16.111	16.111	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P281P	281	P	P	synonymous	possibly_low	0.417562034738973	0.464739102451862	5	0.20783764497692	0.0102077359525868	0.824916333525359	NA	-0.104688037514792	-0.0533267739466648	NA	0.679431549511908	0.653784122680849	NA	0.912609312963564	0.613574077416516	NA	0.259964099976209	0.267897531938086	NA	0.633922590189969	0.613574077416516	NA	0.752525797061313	p.Pro281=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P281Q	281	P	Q	missense	possibly_wt-like	0.956485614394161	0.353314356631766	7	0.13354027461092	0.69475148567117	1.21821974311715	1.15568529392421	0.932737790685669	1.19770071003881	1.06584586038399	0.194166958416686	0.953077260114393	NA	1.19618542719537	0.763125625510011	0.856960641214812	0.738199947357461	0.881467041907254	0.763125625510011	0.452657909011095	0.761087491156992	NA	0.894951349436101	p.Pro281Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.131	-2.782	0.651	8.387	8.387	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.54	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
P281R	281	P	R	missense	wt-like	1.08548754062183	0.116852998840321	4	0.0584264994201603	0.970973706015567	1.2000013752281	NA	NA	NA	0.961682789770761	1.06817158948425	1.24373735863457	1.06835842459774	NA	0.821064880612246	NA	NA	NA	0.71744475035577	0.779131700230356	0.904345915785508	0.862998060994137	NA	p.Pro281Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.131	-2.907	0.776	14.342	14.342	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	1.6	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
P281S	281	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.131	-2.49	0.359	12.006	12.006	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P281T	281	P	T	missense	possibly_wt-like	0.813717667608634	0.458646698289687	3	0.264799794720484	0.294719606842886	1.33271572837438	NA	0.318368799242254	NA	NA	0.899130221462087	NA	NA	1.22365398212156	0.715988354841355	NA	0.454986181861222	NA	NA	0.715988354841355	NA	NA	0.908747377775432	p.Pro281Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.131	-2.913	0.782	20.503	20.503	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	low	1.6	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
P281V	281	P	V	missense	possibly_wt-like	0.981541415094145	0.225459318762114	2	0.15942381317839	0.669076482986459	1.29400634720183	NA	NA	NA	NA	0.822117601915755	NA	NA	1.14096522827254	0.777219170029251	NA	NA	NA	NA	0.687221228236651	NA	NA	0.86721711182185	p.Pro281Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.131	-2.947	0.816	12.96	12.96	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.945	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P281W	281	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.131	-5.634	3.503	1.412	NA	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P281X	281	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P281Y	281	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro281Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.1	69.3	48.1	0.039	360	360	-54.5	360	52.5974025974026	0	0	0	55	0	0	0	0	3	29.9778367775262	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.131	-3.632	1.501	16.303	16.303	39.95	0.004189059	0.008196721	0.119730272	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G282A	282	G	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.827	-2.424	0.597	22.857	22.857	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.515	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
G282C	282	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.827	-3.802	1.975	22.906	22.906	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G282D	282	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.827	-2.827	1	20.377	20.377	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G282E	282	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.827	-2.822	0.995	21.45	21.45	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.77	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
G282F	282	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.827	-4.525	2.698	1.739	NA	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G282H	282	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.827	-3.399	1.572	17.043	17.043	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G282I	282	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.827	-4.198	2.371	3.39	NA	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G282K	282	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.827	-2.843	1.016	14.163	14.163	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G282L	282	G	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.827	-3.214	1.387	9.97	9.97	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G282M	282	G	M	missense	wt-like	1.15144940315394	0.161179971788302	4	0.080589985894151	0.993495933286809	1.30940287302106	NA	1.33778551818778	0.970175356992822	1.07700623459241	1.22083050284273	NA	NA	NA	0.803016125677726	NA	0.924920132961315	0.769876672262258	0.768020024819554	0.836155579093194	NA	NA	NA	p.Gly282Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.827	-3.769	1.942	5.024	5.024	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G282N	282	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.827	-2.445	0.618	26.407	26.407	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.515	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
G282P	282	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.827	-2.953	1.126	42.353	42.353	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G282Q	282	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.827	-3.422	1.595	9.396	9.396	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G282R	282	G	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.827	-3.144	1.317	12.635	12.635	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
G282S	282	G	S	missense	wt-like	1.01299292675016	0.0898237873287974	5	0.040170418892735	0.934260352476513	1.09172550102381	NA	1.14705448855387	0.948879138822768	1.05997317011472	NA	0.930581610868006	NA	0.978476225391445	0.760550148141391	NA	0.836996338219194	0.759431889622337	0.760550148141391	NA	0.75	NA	0.785607325846541	p.Gly282Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.827	-2.505	0.678	9.932	9.932	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.115	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G282T	282	G	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.827	-2.7	0.873	10.251	10.251	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G282V	282	G	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.827	-3.832	2.005	5.388	NA	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.665	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
G282W	282	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.827	-5.616	3.789	0.428	NA	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G282X	282	G	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G282Y	282	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly282Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.827	-4.506	2.679	2.794	NA	83.37	0.003256376	0.008264463	0.09307265	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.665	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P283A	283	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-2.223	-2.814	0.591	12.722	12.722	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
P283C	283	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-2.223	-5.264	3.041	1.57	NA	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P283D	283	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-2.223	-2.387	0.164	20.279	20.279	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P283E	283	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-2.223	-2.656	0.433	15.111	15.111	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P283F	283	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-2.223	-4.414	2.191	6.224	NA	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P283G	283	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-2.223	-2.594	0.371	25.177	25.177	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P283H	283	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-2.223	-4.799	2.576	2.234	NA	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P283I	283	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-2.223	-3.375	1.152	22.639	22.639	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P283K	283	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-2.223	-2.983	0.76	10.794	10.794	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P283L	283	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-2.223	-2.959	0.736	34.104	34.104	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.5
P283M	283	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-2.223	-3.727	1.504	5.145	5.145	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P283N	283	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-2.223	-2.753	0.53	12.417	12.417	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P283Q	283	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-2.223	-2.995	0.772	8.334	8.334	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	low	1.935	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
P283R	283	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-2.223	-3.15	0.927	18.867	18.867	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
P283S	283	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-2.223	-2.655	0.432	18.936	18.936	86.35	0.004808947	0.025	0.137447722	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 3, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
P283T	283	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-2.223	-2.823	0.6	15.804	15.804	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
P283V	283	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-2.223	-3.005	0.782	14.698	10.489	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P283W	283	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-2.223	-5.584	3.361	1.303	NA	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P283X	283	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P283Y	283	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro283Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-2.223	-3.286	1.063	15.043	15.043	86.35	0.004808947	0.025	0.137447722	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E284A	284	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.946	-2.672	0.726	12.075	12.075	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.16	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
E284C	284	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.946	-3.77	1.824	17.869	17.869	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E284D	284	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.946	-2.483	0.537	35.931	35.931	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.505	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	T	B	0.285714285714286
E284F	284	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.946	-4.381	2.435	5.434	NA	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E284G	284	E	G	missense	wt-like	1.20733782140885	0.0627698211944049	4	0.0313849105972025	1.14582452698033	1.26885111583738	NA	1.14048814994481	1.21468345602393	1.28965860068483	NA	NA	NA	1.18452107898184	0.875186000460345	NA	0.833969366629003	0.889796271492862	0.861279047710605	NA	NA	NA	0.889092953210085	p.Glu284Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.946	-3.612	1.666	5.482	NA	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.505	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
E284H	284	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.946	-3.339	1.393	9.927	9.927	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E284I	284	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.946	-3.364	1.418	13.071	13.071	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E284K	284	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.946	-2.64	0.694	12.169	12.169	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.855	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E284L	284	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.946	-3.654	1.708	8.068	NA	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E284M	284	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.946	-4.86	2.914	1.778	NA	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E284N	284	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.946	-2.721	0.775	27.114	27.114	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.505	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E284P	284	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.946	-3.344	1.398	17.187	17.187	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E284Q	284	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.946	-3.11	1.164	6.583	6.583	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
E284R	284	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.946	-2.917	0.971	10.5	10.5	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E284S	284	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.946	-2.764	0.818	10.969	10.969	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E284T	284	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.946	-3.152	1.206	6.956	6.956	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E284V	284	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.946	-2.702	0.756	12.292	12.292	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.855	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E284W	284	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.946	-3.46	1.514	41.399	41.399	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E284X	284	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	2	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E284Y	284	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu284Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.946	-3.474	1.528	10.632	10.632	86.35	0.005031716	0.025210084	0.143814836	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E285A	285	E	A	missense	wt-like	0.853855403591945	0.152947391463806	8	0.0540750688344254	0.747870216214947	0.959840590968943	0.763409497290105	0.900502409959369	0.853922680174257	0.947572329250723	0.626940287493698	1.03795878671676	1.02231629312906	0.678220944721587	0.712058423405578	0.67032502825937	0.723339979349878	0.712860260663583	0.711256586147573	0.614315118206627	0.80292327750341	0.838200073190617	0.634804694536437	p.Glu285Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.012	-2.704	0.692	11.356	11.356	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E285C	285	E	C	missense	wt-like	0.9542720812932	0.12760373575239	6	0.0520940069777156	0.852169703806499	1.0563744587799	NA	1.10936979721273	1.0291519495267	0.805962490218236	0.992745194952177	0.996813449006651	NA	0.791589606842705	0.766800476448772	NA	0.819624329727666	0.798801887290613	0.649153372989863	0.750957088671596	0.782643864225947	NA	0.691743884807561	p.Glu285Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.012	-5.28	3.268	1.524	NA	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E285D	285	E	D	missense	possibly_wt-like	0.848051083920329	0.460556965827922	7	0.174074170879879	0.506871978357095	1.18923018948356	NA	1.13690575866093	1.14417873697103	1.30788640516577	0.597412149598753	-0.0242209660064677	0.709092848550936	1.06510265450135	0.829115281548861	NA	0.832317944537198	0.855217058427145	0.869272879458536	0.60328524172367	0.279403885532686	0.669499995443161	0.829115281548861	p.Glu285Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.012	-2.825	0.813	15.455	15.455	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
E285F	285	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu285Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.012	-4.377	2.365	5.311	NA	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E285G	285	E	G	missense	wt-like	0.99235219773364	0.148086520898704	8	0.0523564915648986	0.889735359909564	1.09496903555772	0.760006162739566	0.907786328790372	1.00616690215273	0.951555715236726	0.96911693623169	1.27882508713558	0.984426907696975	1.08093354188548	0.764829927223929	0.6687058015944	0.726697743345828	0.787528814209169	0.713003506210955	0.74213104023869	0.921639698917209	0.817793100536302	0.837066313977584	p.Glu285Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.012	-2.77	0.758	27.96	27.96	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
E285H	285	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu285His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.012	-3.684	1.672	13.002	13.002	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E285I	285	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu285Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.012	-3.977	1.965	6.845	NA	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E285K	285	E	K	missense	wt-like	1.21545940845806	0.048666402930742	3	0.0280975608325547	1.16038920117283	1.27052961574329	NA	1.22354224548098	1.16325763712954	1.25957834276365	NA	NA	NA	NA	0.864574351988528	NA	0.872255906907378	0.864574351988528	0.84808730423938	NA	NA	NA	NA	p.Glu285Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.012	-2.823	0.811	24.132	24.132	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	1.4	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E285L	285	E	L	missense	possibly_low	0.672448351173109	0.474977883029476	6	0.193908908754928	0.292393873731986	1.05250282861423	NA	1.16795307925346	0.977811081833317	0.906695751225635	-0.0889045123964519	NA	0.293445719151851	0.777688987970843	0.689046212921985	NA	0.846630236817641	0.77362163231199	0.69333009985542	0.346920006742207	NA	0.445635197775874	0.684762325988549	p.Glu285Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.012	-2.806	0.794	12.393	12.393	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E285M	285	E	M	missense	wt-like	1.05670837258915	0.210128227131477	8	0.0742915471616873	0.911099615796481	1.20231712938181	0.672241891521761	0.912595814998551	1.14911668051266	1.27077678460995	1.26479702917096	1.22962348730488	0.989591673053912	0.964923619540492	0.836576774429614	0.626949622154144	0.728914835546267	0.85763888499601	0.852998398170189	0.852578739825862	0.897389574057161	0.820574809033366	0.778800555891079	p.Glu285Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.012	-3.052	1.04	5.466	5.466	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E285N	285	E	N	missense	possibly_low	0.676009770912735	0.384143827246222	2	0.271630705196757	0.143623371631874	1.2083961701936	NA	NA	NA	NA	0.404379065715978	NA	NA	0.947640476109492	0.650650106797904	NA	NA	NA	NA	0.531180082911206	NA	NA	0.770120130684601	p.Glu285Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.012	-2.78	0.768	16.19	16.19	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E285P	285	E	P	missense	possibly_wt-like	0.861500843021508	0.297294602682817	8	0.10510951478359	0.655489979613191	1.06751170642982	0.287705199453236	0.860241476072329	1.13699526322209	1.11012479741451	0.602915324708309	1.02938808807634	0.779590317915563	1.08504627730969	0.745006844123008	0.443996093428001	0.704780366401713	0.851693906038863	0.78254422158773	0.605340885799109	0.798699014209467	0.707469466658286	0.839131927353203	p.Glu285Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.012	-3.392	1.38	22.588	22.588	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E285Q	285	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu285Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.012	-2.688	0.676	10.298	10.298	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E285R	285	E	R	missense	wt-like	1.00625351963882	0.0778492492195391	8	0.0275238660167088	0.952307733530765	1.06019930574688	1.06916419398837	1.11671884618568	1.00547747231794	0.967246507993066	0.912041238466594	0.8919734582472	1.0440212153236	1.04338522458811	0.801493307564263	0.815795933479436	0.823012117622941	0.78719068164909	0.719884727557001	0.72081110808559	0.730971095962489	0.849890200877749	0.818207744572649	p.Glu285Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.012	-3.139	1.127	17.501	17.501	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E285S	285	E	S	missense	wt-like	1.06831760980527	0.185210940021944	8	0.0654819558197259	0.939975334761361	1.19665988484917	0.837710505538404	0.843453003974332	1.14648975304743	1.23348373534267	1.37508566338918	1.05089904086123	0.976813549956892	1.08260562633198	0.825168035148765	0.705675703311503	0.697041163307118	0.856350501952314	0.836643473937731	0.893775716662971	0.809301175372665	0.813692596359799	0.837906115141919	p.Glu285Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.012	-2.683	0.671	10.969	10.969	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E285T	285	E	T	missense	wt-like	1.27684893263581	0.180198165427519	2	0.127419344731174	1.02711160602901	1.5265862592426	NA	NA	NA	NA	1.40426827736698	NA	NA	1.14942958790463	0.888072423446528	NA	NA	NA	NA	0.904676526892527	NA	NA	0.87146832000053	p.Glu285Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.012	-3.197	1.185	20.503	20.503	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E285V	285	E	V	missense	wt-like	0.939341967197517	0.123234464813225	8	0.0435699628726632	0.85394640915935	1.02473752523568	0.955020585393121	1.10516287191694	0.948522316341114	0.688098086125405	1.00487265555902	0.957469207334576	0.855450544581736	1.00013947032823	0.760372984944756	0.76148908473192	0.817685007967002	0.759256885157593	0.597463756921559	0.755487153961228	0.76325216199767	0.748327283523687	0.796487648523614	p.Glu285Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.012	-2.738	0.726	11.223	11.223	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E285W	285	E	W	missense	wt-like	1.2335211265637	0.24617810717297	3	0.142130996444907	0.95494949244489	1.5120927606825	NA	NA	NA	NA	1.5130612790776	1.04906729709995	1.13843480351355	NA	0.900740735675719	NA	NA	NA	NA	0.945314828411826	0.808398358897681	0.900740735675719	NA	p.Glu285Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.012	-5.545	3.533	1.112	NA	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E285X	285	E	X	nonsense	low	0.142532115290682	0.261053773763958	2	0.184592893682833	-0.219263308129703	0.504327538711066	-0.0420607783921518	0.327125008973515	NA	NA	NA	NA	NA	NA	0.37306191581729	0.287101184450396	0.459022647184185	NA	NA	NA	NA	NA	NA	p.Glu285Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	1	0	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E285Y	285	E	Y	missense	wt-like	0.929987954919517	0.20866550257924	8	0.0737743959367397	0.785392795902309	1.07458311393673	1.17271929908418	0.942328095476424	0.961477399481538	1.14652922058221	0.495553053453389	0.869032478726917	0.977889000645505	0.874375091905983	0.754115827024482	0.865065020892059	0.742620916465399	0.765610737583566	0.798509437474661	0.56523701622614	0.719664113675471	0.814271826995063	0.733322733825549	p.Glu285Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.012	-3.289	1.277	12.838	12.838	42.68	0.004318317	0.016949153	0.123424685	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.09	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T286A	286	T	A	missense	wt-like	1.14705987454636	0.146339368054936	3	0.0844890735395571	0.981464333321674	1.31265541577105	NA	NA	NA	NA	1.30980926396663	1.10505125438291	1.02631910528954	NA	0.840355961373225	NA	NA	NA	NA	0.869392512227782	0.835991322519657	0.840355961373225	NA	p.Thr286Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.134	-2.827	0.693	25.588	25.588	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.68	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
T286C	286	T	C	missense	wt-like	0.979222152021127	0.251292734744144	7	0.0949797260586178	0.793065309684756	1.1653789943575	NA	0.550621175415498	1.1997823082652	1.26493531416547	1.1275567596721	0.92195878360034	0.782175623302136	1.00752509972715	0.800197066538689	NA	0.562050618572025	0.882487966882978	0.850436612303849	0.8013143076952	0.745750043929323	0.708861895058092	0.800197066538689	p.Thr286Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.134	-3.83	1.696	12.712	12.712	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T286D	286	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.134	-3.085	0.951	21.756	21.756	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286E	286	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.134	-3.06	0.926	11.278	11.278	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286F	286	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.134	-3.297	1.163	12.243	12.243	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T286G	286	T	G	missense	wt-like	1.08877066855268	0.363133904620398	5	0.162398419133227	0.770475615905313	1.40706572120004	NA	0.868076551602917	1.09129265760981	0.699283317169841	1.65945922740996	NA	NA	1.12574158897087	0.829278950581201	NA	0.708392204360449	0.829278950581201	0.602369057234848	1	NA	NA	0.859571068562642	p.Thr286Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.134	-2.804	0.67	45.799	45.799	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286H	286	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.134	-3.464	1.33	16.164	16.164	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T286I	286	T	I	missense	possibly_low	0.586691795366416	0.425892347057271	4	0.212946173528636	0.169324964604674	1.00405862612816	NA	0.739051530863228	0.351830035382376	0.147122650732146	NA	NA	NA	1.10876296448792	0.557760763969434	NA	0.648913841233648	0.46660768670522	0.360218145974956	NA	NA	NA	0.851043587406131	p.Thr286Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.134	-2.966	0.832	13.947	13.947	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
T286K	286	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.134	-3.268	1.134	7.907	7.907	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286L	286	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.134	-2.666	0.532	32.706	32.706	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286M	286	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.134	-3.75	1.616	6.752	6.752	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T286N	286	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.134	-2.823	0.689	28.764	28.764	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.425	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
T286P	286	T	P	missense	possibly_low	0.469314328199396	0.374370897894711	3	0.216143138676273	0.0456815608884541	0.892947095510338	NA	NA	NA	NA	0.661362203124927	0.0378924487439391	0.708688332729322	NA	0.627173005794054	NA	NA	NA	NA	0.627173005794054	0.31001789134478	0.669282125894321	NA	p.Thr286Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.134	-3.443	1.309	23.816	23.816	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
T286Q	286	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.134	-3.5	1.366	6.689	6.689	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T286R	286	T	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.134	-3.448	1.314	16.306	16.306	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T286S	286	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.134	-2.251	0.117	19.755	19.755	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	neutral	0.28	Neutral	TOLERATED	neutral	DAMAGING	null	D	N	T	T	D	B	0.214285714285714
T286V	286	T	V	missense	wt-like	1.13204367806747	0.161212691530509	4	0.0806063457652544	0.974058143442188	1.29002921269275	NA	NA	NA	NA	1.35979648085642	1.00293442094708	1.03495799768734	1.13048581277904	0.853481328746329	NA	NA	NA	NA	0.88806462863359	0.785660724131537	0.845008811740551	0.861953845752106	p.Thr286Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.134	-2.584	0.45	22.514	22.514	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.74	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T286W	286	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.134	-5.531	3.397	2.456	NA	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T286X	286	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr286Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T286Y	286	T	Y	missense	wt-like	1.2574120661428	0.0905260112523384	3	0.0522652169652006	1.15497412324684	1.35985000903877	NA	1.22131276743288	1.19050531969529	1.36041811130024	NA	NA	NA	NA	0.877938044995814	NA	0.871228155048333	0.877938044995814	0.892310740146017	NA	NA	NA	NA	p.Thr286Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.134	-3.544	1.41	28.353	28.353	86.35	0.004253489	0.017094017	0.121571786	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S287A	287	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.134	-2.703	0.569	11.788	11.788	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
S287C	287	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.134	-3.833	1.699	15.23	15.23	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S287D	287	S	D	missense	wt-like	1.1356373372938	0.064139362991535	4	0.0320696814957675	1.07278191656643	1.19849275802118	NA	NA	1.17072042042137	1.20836600016309	1.07953986180574	NA	1.08392306678501	NA	0.846931272446491	NA	NA	0.868234492429877	0.825628052463106	0.783378179977125	NA	0.871381074438871	NA	p.Ser287Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.134	-3.061	0.927	19.098	19.098	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S287E	287	S	E	missense	wt-like	0.893766645970678	0.0936964834153023	8	0.0331267093981466	0.828839488623986	0.95869380331737	1.01648961900077	0.937376262074047	0.764527719320579	0.8850341668004	0.962449628364678	0.766780221118114	0.965396227436596	0.852079323650239	0.730882638041257	0.79073460755943	0.740338204604075	0.669016281992575	0.683830378620758	0.739640548541969	0.669266768410933	0.807543301885894	0.722124727540546	p.Ser287Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.134	-3.038	0.904	12.384	12.384	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S287F	287	S	F	missense	wt-like	1.08307012901709	0.231550449699621	7	0.0875178436957668	0.911538307368784	1.2546019506654	0.677871717921889	0.886654478046231	1.1277365078139	1.39197006864061	NA	1.1445071005662	1.1891867315882	1.16356429854262	0.855438031563589	0.629628161360581	0.716956315792508	0.84715292665076	0.906147899665718	NA	0.855438031563589	0.928075388813062	0.87856745095423	p.Ser287Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.134	-3.119	0.985	30.416	30.416	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S287G	287	S	G	missense	wt-like	0.951549928023522	0.145378982840281	8	0.0513992323041826	0.850809283874317	1.05229057217273	1.18505032304244	0.981304901457267	0.960728518434059	0.953414490200432	0.774625292301891	1.07357400873969	0.736518405447603	0.947183484564799	0.762916007544973	0.870931832544895	0.760588568060113	0.765243447029834	0.713818674836045	0.669481054074807	0.82047704778621	0.684271219183985	0.76989060756923	p.Ser287Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.134	-2.783	0.649	45.799	45.799	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.75	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S287H	287	S	H	missense	wt-like	1.12102008009479	0.113647192659886	5	0.0508245696479039	1.02140575405515	1.22063440613443	1.28654775012861	1.17005923558431	0.992006216881819	1.05036656808294	NA	NA	NA	1.10612062979627	0.847601139440483	0.919221925077158	0.847601139440483	0.780583671249703	0.756337158014595	NA	NA	NA	0.849716479941399	p.Ser287His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.134	-3.745	1.611	29.517	29.517	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S287I	287	S	I	missense	wt-like	1.01140021065896	0.207287113463136	7	0.0783471646016983	0.857842589748804	1.16495783156912	NA	0.94779895715967	1.04853576589704	0.613767013256193	1.25232116907285	1.02338022284673	1.20051381513294	0.993484531247327	0.79573790151269	NA	0.745142891629186	0.808308727758894	0.564865750355229	0.847918534147114	0.79573790151269	0.934176081170953	0.793145218301004	p.Ser287Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.134	-2.852	0.718	14.89	14.89	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S287K	287	S	K	missense	possibly_low	0.652271331500301	0.0783637211259136	3	0.045243315486747	0.563596062605093	0.740946600395508	NA	0.572312919742032	0.655564544404986	0.728936530353884	NA	NA	NA	NA	0.615373519578437	NA	0.572050147644066	0.615575024551406	0.615373519578437	NA	NA	NA	NA	p.Ser287Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.134	-3.767	1.633	10.669	NA	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S287L	287	S	L	missense	wt-like	1.04097981613218	0.134138853828547	8	0.0474252465813785	0.948028040874743	1.13393159138961	0.858374737531289	0.893114746148603	1.11936304907396	1.14668861324202	1.09180917256865	0.905000727643634	1.10406954793292	1.20941793491633	0.793270285518592	0.715507259673984	0.719934390664238	0.843046143193495	0.79857933937128	0.787961231665904	0.73739188127305	0.88223183607508	0.901597350727734	p.Ser287Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.134	-2.678	0.544	32.613	32.613	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	D	0.285714285714286
S287M	287	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.134	-3.751	1.617	14.188	14.188	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.79	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S287N	287	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.134	-2.515	0.381	14.304	14.304	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S287P	287	S	P	missense	wt-like	1.15283246859223	0.156822196424612	8	0.055445019266206	1.04416222770833	1.26150270947612	1.14632978284309	1.15482529247782	1.09409084691208	1.2803767728775	1.46790299242744	1.07220200852682	0.971869737998717	1.03506231467434	0.835614938731756	0.852509508720488	0.840578548048935	0.830651329414578	0.857208487820488	0.928446500117463	0.819800826350636	0.811029891903445	0.814027579240158	p.Ser287Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.134	-3.015	0.881	44.44	44.44	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	D	0.357142857142857
S287Q	287	S	Q	missense	possibly_low	0.346304162645914	0.570104515418562	6	0.232744193805357	-0.109866074823396	0.802474400115224	NA	1.06118105858565	0.913907678222892	NA	-0.30299797750997	-0.0835744050142916	-0.042416088542617	0.531724710133818	0.414087622118951	NA	0.797410132215801	0.742280050659684	NA	0.266947998875952	0.250150196389127	0.264742247228152	0.56122724536195	p.Ser287Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.134	-2.923	0.789	17.412	17.412	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S287R	287	S	R	missense	wt-like	0.940878293807942	0.146253926368653	8	0.0517085715552162	0.839531355867706	1.04222523174818	0.982686519760346	0.74203327000054	0.87440940163814	0.778425251607137	1.11152851360336	1.12412646720055	1.04181952801604	0.87199739863742	0.753390214338755	0.774651886676156	0.650288372794594	0.722908023650711	0.637076874556393	0.795327151478118	0.845392973973094	0.848704386640692	0.732128542001353	p.Ser287Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.134	-3.22	1.086	30.392	30.392	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S287S	287	S	S	synonymous	wt-like	0.991490796519906	0.233181909367439	8	0.0824422546818716	0.829906946539159	1.15307464650065	1.17243039107145	0.919796861027086	1.028533274767	0.880434646811714	1.10404701813549	1.11667989586326	1.21792935948768	0.492074924995575	0.795515493322515	0.864927565243492	0.732234396574993	0.798498456731333	0.681813252040909	0.792532529913696	0.841722762326928	0.943555978293966	0.541313217817163	p.Ser287=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S287T	287	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.134	-2.588	0.454	21.174	21.174	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	T	T	D	B	0.285714285714286
S287V	287	S	V	missense	wt-like	1.05317565905523	0.18223488522629	8	0.0644297615561308	0.926895646872708	1.17945567123775	0.679266396482749	1.03378453426426	1.23799458621642	1.27847655204185	1.0039645195419	1.11811391851394	1.02700692066698	1.04679784471372	0.830324070295469	0.630291716671195	0.784780795575061	0.901229272695579	0.85637514304438	0.755147930806212	0.842429552928268	0.840726414191042	0.819921726399897	p.Ser287Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.134	-3.003	0.869	23.583	23.583	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S287W	287	S	W	missense	wt-like	1.115232452835	0.247851189908001	4	0.123925594954001	0.872342749962462	1.35812215570754	NA	1.11431070018262	1.19306582725508	NA	1.37281215876747	NA	0.780741125134846	NA	0.850547927538453	NA	0.821902002843565	0.879193852233341	NA	0.89292647668549	NA	0.70808928382308	NA	p.Ser287Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.134	-5.58	3.446	1.413	NA	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S287X	287	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	4	0	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S287Y	287	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser287Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.134	-4.375	2.241	7.054	NA	85.11	0.003479332	0.00862069	0.099445088	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E288A	288	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-2.248	-2.951	0.703	8.621	8.194	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E288C	288	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-2.248	-5.291	3.043	1.556	NA	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E288D	288	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-2.248	-2.257	0.009	36.03	36.03	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.21	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
E288E	288	E	E	synonymous	low	0.193445313559477	0.0388356252637506	2	0.0274609339756176	0.139622871985434	0.24726775513352	NA	0.220906247535095	0.165984379583859	NA	NA	NA	NA	NA	0.392758406490299	NA	0.410057585775983	0.375459227204614	NA	NA	NA	NA	NA	p.Glu288=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E288F	288	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-2.248	-3.241	0.993	12.051	12.051	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E288G	288	E	G	missense	wt-like	0.916093512280571	0.000601639129491062	2	0.000425423108290301	0.915259698310131	0.916927326251011	0.91566808917228	NA	NA	NA	NA	NA	NA	0.916518935388861	0.74862774419971	0.742766091071533	NA	NA	NA	NA	NA	NA	0.754489397327888	p.Glu288Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-2.248	-2.555	0.307	19.863	19.863	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E288H	288	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-2.248	-4.731	2.483	3.847	NA	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E288I	288	E	I	missense	wt-like	1.0486363091702	0.0422719438824461	2	0.0298907781732148	0.990051460480827	1.10722115785958	NA	NA	NA	NA	1.01874553099699	NA	1.07852708734342	NA	0.814572016639323	NA	NA	NA	NA	0.760669197715179	NA	0.868474835563467	NA	p.Glu288Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-2.248	-4.084	1.836	13.689	NA	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E288K	288	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-2.248	-2.627	0.379	13.338	13.338	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E288L	288	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-2.248	-2.961	0.713	11.648	11.648	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E288M	288	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-2.248	-4.849	2.601	2.644	NA	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.735	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E288N	288	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-2.248	-2.84	0.592	14.461	14.461	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.53	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E288P	288	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-2.248	-3.33	1.082	20.01	20.01	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.735	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E288Q	288	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-2.248	-2.781	0.533	10.67	10.67	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
E288R	288	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-2.248	-2.755	0.507	11.525	11.525	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E288S	288	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-2.248	-2.613	0.365	17.354	17.354	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.84	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E288T	288	E	T	missense	wt-like	1.07744993551744	0.150434015091029	6	0.0614144294885274	0.957079865588854	1.19782000544603	1.19091129553271	1.19829529033172	NA	NA	0.883512025387419	0.988434311676036	0.962209858270468	1.2413368319063	0.833222314992202	0.873720345633449	0.860617485478688	NA	NA	0.710154367808272	0.778514016270066	0.805827144505715	0.917628554721432	p.Glu288Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-2.248	-2.795	0.547	13.486	13.486	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.53	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E288V	288	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-2.248	-3.217	0.969	22.447	22.447	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E288W	288	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-2.248	-5.52	3.272	2.244	NA	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E288X	288	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	2	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E288Y	288	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu288Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-2.248	-3.484	1.236	25.912	25.912	86.35	0.003558092	0.017391304	0.101696209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.39	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K289A	289	K	A	missense	wt-like	0.959317498923687	0.135216207902693	7	0.0511069227622474	0.859149770949011	1.05948522689836	0.852621284468423	1.10584137752627	0.828855048667138	NA	1.04733683881924	0.775060739363897	1.03447535126104	1.0710318523598	0.771349132727931	0.712769901804312	0.817997787633954	0.700565779066016	NA	0.771349132727931	0.673348009713189	0.844748861564244	0.832093209652634	p.Lys289Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.946	-2.793	0.847	13.728	13.728	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K289C	289	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.946	-3.762	1.816	16.909	16.909	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K289D	289	K	D	missense	wt-like	1.20063491706657	0.138867364740336	3	0.080175110414487	1.04349458819766	1.35777524593549	NA	1.2685535149646	1.04088037562167	1.29247086061346	NA	NA	NA	NA	0.862512368636578	NA	0.893005344619509	0.804554122748203	0.862512368636578	NA	NA	NA	NA	p.Lys289Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.946	-2.802	0.856	19.787	19.787	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K289E	289	K	E	missense	possibly_wt-like	0.885666535248645	0.374319451573725	4	0.187159725786863	0.518840213350002	1.25249285714729	NA	0.348827703041497	NA	NA	1.20844746153241	NA	0.942439623890485	1.04295135253018	0.806584430033695	NA	0.469027223902755	NA	NA	0.831530044742802	NA	0.795179026892805	0.817989833174585	p.Lys289Glu	1	0	no	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.946	-2.614	0.668	16.29	16.29	42.68	0.003495204	0.00877193	0.099898746	8.133e-06	2	245906	Hereditary cancer-predisposing syndrome	Likely pathogenic(Last reviewed: Apr 3, 2014)	criteria provided, single submitter	0	1	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.585	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
K289F	289	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.946	-4.429	2.483	5.116	NA	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K289G	289	K	G	missense	possibly_wt-like	0.75839251110363	0.278344404867743	8	0.0984096080936574	0.56551322350736	0.9512717986999	0.172738821585116	0.882931979523919	0.807212009310426	0.739287067687655	0.642530761686866	1.09981070006551	0.739035135081087	0.983593613888462	0.687788805128686	0.389297790380012	0.715240306621731	0.689950897121108	0.619912763678478	0.620138750068317	0.833408396416234	0.685626713136265	0.788177524275906	p.Lys289Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.946	-2.875	0.929	23.279	23.279	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K289H	289	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.946	-3.63	1.684	15.549	15.549	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K289I	289	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.946	-3.173	1.227	8.287	8.287	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K289K	289	K	K	synonymous	wt-like	1.32023695098526	0.340474791683116	3	0.196573212630529	0.934960533904094	1.70551336806643	NA	NA	0.978523316699799	NA	1.65945922740996	NA	1.32272830884603	NA	1	NA	NA	0.773970949656017	NA	1	NA	1	NA	p.Lys289=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K289L	289	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.946	-3.122	1.176	14.629	14.629	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.135	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K289M	289	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.946	-4.841	2.895	1.942	NA	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.135	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K289N	289	K	N	missense	possibly_wt-like	0.827611414249757	0.286825116228462	5	0.128272091508224	0.576202734672012	1.0790200938275	NA	1.21699090933135	1.0207168477959	0.763326273961219	0.538759209551963	NA	0.598263830608356	NA	0.630455194639132	NA	0.869235851198496	0.794664870876697	0.630455194639132	0.581376149915034	NA	0.609808218639001	NA	p.Lys289Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.946	-2.851	0.905	9.981	9.981	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
K289P	289	K	P	missense	possibly_wt-like	0.955752000126962	0.350260736956366	7	0.132386114859536	0.696279982949088	1.21522401730484	1.24471329898161	0.930709091783965	0.844987248317732	NA	0.306980912240103	1.36972738912526	0.848099744387214	1.14504631605285	0.744368191106476	0.89931807554204	0.737264751305883	0.708477856107526	NA	0.494798188247577	0.966442961024558	0.744368191106476	0.869266830229817	p.Lys289Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.946	-3.337	1.391	19.274	19.274	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K289Q	289	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.946	-3.331	1.385	10.935	10.935	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.5
K289R	289	K	R	missense	wt-like	1.14055944839624	0.14058171969237	2	0.0994062873053413	0.945726705440932	1.33539219135155	NA	NA	NA	NA	1.0411531610909	1.23996573570158	NA	NA	0.835763140513752	NA	NA	NA	NA	0.769039295182583	0.902486985844921	NA	NA	p.Lys289Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.946	-2.35	0.404	30.733	30.733	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
K289S	289	K	S	missense	possibly_low	0.537422553209272	0.31658380002885	6	0.129244795150331	0.284107409525366	0.790737696893179	0.402794960409104	0.256472200492074	NA	NA	0.799154780545651	0.311375630703331	1.05318219705527	0.401555550050202	0.497301568442537	0.498753099251966	0.426452891529848	NA	NA	0.678643745826024	0.444810282902357	0.854824245110796	0.495850037633107	p.Lys289Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.946	-2.892	0.946	9.168	9.168	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K289T	289	K	T	missense	wt-like	1.03877366028082	0.21017643413075	7	0.0794392251651875	0.88307563999728	1.19447168056435	1.01154588774613	1.33585609143382	1.14341336197279	1.22481290138769	0.896866744921727	NA	0.936052268444157	0.722868366059389	0.791738839451385	0.788382496312922	0.924030699699142	0.85484167837465	0.832840866343228	0.715142860731598	NA	0.791738839451385	0.657228775151874	p.Lys289Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.946	-2.517	0.571	12.143	12.143	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
K289V	289	K	V	missense	possibly_wt-like	0.891209617556636	0.3776046461542	7	0.142721141089508	0.611481321188741	1.17093791392453	0.783012217900113	0.951878354660348	1.12008672274391	1.08562854700276	0.0980169795638854	1.22966103258372	NA	0.970183468441704	0.771801353215879	0.679651542431377	0.747023425222538	0.843401070726851	0.771801353215879	0.41674225478466	0.89740807909974	NA	0.781442304781646	p.Lys289Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.946	-3.728	1.782	5.38	NA	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K289W	289	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.946	-5.571	3.625	1.071	NA	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K289X	289	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K289Y	289	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys289Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.946	-3.505	1.559	12.365	12.365	42.68	0.003495204	0.00877193	0.099898746	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V290A	290	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-2.225	-2.605	0.38	24.15	24.15	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	not specified	Uncertain significance(Last reviewed: Feb 4, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
V290C	290	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-2.225	-3.818	1.593	19.548	19.548	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V290D	290	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-2.225	-3.12	0.895	13.29	13.29	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V290E	290	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-2.225	-2.912	0.687	11.647	11.647	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V290F	290	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-2.225	-3.465	1.24	13.964	13.964	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V290G	290	V	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-2.225	-2.991	0.766	20.749	20.749	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
V290H	290	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-2.225	-3.224	0.999	18.009	18.009	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V290I	290	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-2.225	-2.773	0.548	10.578	10.578	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
V290K	290	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-2.225	-3.285	1.06	7.769	7.769	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.25	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V290L	290	V	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-2.225	-2.367	0.142	33.172	33.172	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.66	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V290M	290	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-2.225	-3.441	1.216	14.549	14.549	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.865	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
V290N	290	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-2.225	-3.182	0.957	13.203	13.203	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V290P	290	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-2.225	-4.25	2.025	2.423	NA	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.905	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V290Q	290	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-2.225	-3.271	1.046	9.661	9.661	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V290R	290	V	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-2.225	-3.454	1.229	14.342	14.342	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V290S	290	V	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-2.225	-2.876	0.651	8.568	8.568	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.905	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
V290T	290	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-2.225	-2.878	0.653	12.143	12.143	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V290W	290	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-2.225	-3.865	1.64	44.603	44.603	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.25	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V290X	290	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V290Y	290	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val290Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-2.225	-2.903	0.678	16.224	16.224	89.83	0.003972012	0.008849558	0.113526725	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.56	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E291A	291	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.839	-2.631	0.792	14.447	14.447	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E291C	291	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.839	-5.242	3.403	1.556	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E291D	291	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.839	-2.593	0.754	17.424	17.424	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	low	1.835	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.642857142857143
E291F	291	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.839	-3.491	1.652	18.555	18.555	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E291G	291	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.839	-3.624	1.785	3.908	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E291H	291	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.839	-4.757	2.918	1.527	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E291I	291	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.839	-3.922	2.083	13.689	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E291K	291	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.839	-2.732	0.893	10.519	10.519	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E291L	291	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.839	-2.598	0.759	19.102	19.102	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E291M	291	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.839	-3.36	1.521	8.32	8.32	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E291N	291	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.839	-3.023	1.184	12.417	12.417	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.295	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E291P	291	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.839	-3.308	1.469	24.43	24.43	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E291Q	291	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.839	-2.593	0.754	10.67	10.67	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E291R	291	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.839	-3.058	1.219	18.867	18.867	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.09	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E291S	291	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.839	-2.604	0.765	12.006	12.006	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.09	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E291T	291	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.839	-3.12	1.281	12.57	12.57	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.09	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E291V	291	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.839	-2.79	0.951	22.447	22.447	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E291W	291	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.839	-5.566	3.727	0.862	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E291X	291	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E291Y	291	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu291Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.839	-4.386	2.547	4.304	NA	83.37	0.003130861	0.008928571	0.089485223	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.95	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N292A	292	N	A	missense	wt-like	1.09782754183117	0.140858422073838	6	0.0575052100090817	0.985119401289955	1.21053568237238	NA	1.11019801222971	1.03795872222137	1.22696410098879	1.26146516373434	1.07991434168154	NA	0.870464910131255	0.821804073825325	NA	0.820006122912001	0.803121190643937	0.833784278243734	0.851334162048741	0.82360202473865	NA	0.731358852626809	p.Asn292Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.714	-3.352	1.638	5.395	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292C	292	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.714	-5.244	3.53	0.9	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N292D	292	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.714	-2.756	1.042	15.259	15.259	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N292E	292	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.714	-2.469	0.755	12.384	12.384	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292F	292	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.714	-3.374	1.66	12.912	12.912	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N292G	292	N	G	missense	possibly_wt-like	1.01295863499459	0.492282602015681	7	0.186065334242468	0.648277281107949	1.37763998888124	1.21585463521586	0.992552484585427	1.14045324383952	0.786376868089799	1.65945922740996	0.0733187412853125	NA	1.22269524453627	0.853389881147386	0.885587800956631	0.765773514590331	0.853389881147386	0.640564068219948	1	0.32747854344579	NA	0.908265853686081	p.Asn292Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.714	-2.513	0.799	24.544	24.544	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N292H	292	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.714	-3.147	1.433	29.517	29.517	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.985	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N292I	292	N	I	missense	possibly_wt-like	0.932526555453514	0.411260740818753	5	0.183921394589531	0.572047246071654	1.29300586483537	NA	0.792969456846741	0.758630414456247	0.645438204930154	1.65945922740996	NA	0.80613547362447	NA	0.673769097697133	NA	0.673769097697133	0.666123934300724	0.578755200275693	1	NA	0.721766512136292	NA	p.Asn292Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.714	-4.012	2.298	6.804	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N292K	292	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.714	-2.986	1.272	10.244	10.244	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N292L	292	N	L	missense	possibly_wt-like	0.816382835422088	0.420515171204464	7	0.15893979507668	0.504866561361617	1.12789910948256	1.14417325514613	1.16302723025051	1.07127355854731	1.06829865657837	0.0385221016690628	0.518429829158649	NA	0.710955216604574	0.764201303061321	0.851483483480005	0.844359503327149	0.819460534152275	0.764201303061321	0.394518667341279	0.546861642667411	NA	0.651245418985852	p.Asn292Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.714	-2.836	1.122	12.672	12.672	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292M	292	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.714	-4.795	3.081	1.682	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N292P	292	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.714	-4.089	2.375	1.519	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.985	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N292Q	292	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.714	-3.215	1.501	5.839	5.839	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292R	292	N	R	missense	wt-like	1.05286326860084	0.281499374556878	5	0.125890347426571	0.806122721643529	1.29960381555816	1.21981183102651	1.09914833035192	1.13838530119185	1.24627690217488	NA	NA	NA	0.560693978259049	0.84225393696891	0.887470541803869	0.814912405527609	0.852375653583871	0.84225393696891	NA	NA	NA	0.575777003989564	p.Asn292Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.714	-2.936	1.222	15.11	15.11	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292S	292	N	S	missense	possibly_wt-like	0.937078922674349	0.338545853543796	3	0.195459539676542	0.553985264473548	1.32017258087515	NA	0.569549864521706	1.00549576641728	1.23619113708406	NA	NA	NA	NA	0.787199654035156	NA	0.570776425688497	0.787199654035156	0.837830809144083	NA	NA	NA	NA	p.Asn292Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.714	-2.584	0.87	10.86	10.86	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.64	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
N292T	292	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.714	-2.803	1.089	9.641	9.641	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N292V	292	N	V	missense	wt-like	1.18841764802656	0.176097690513141	3	0.101670049021433	0.989148013638134	1.387687282415	NA	1.32287396147112	0.989085284576279	1.25329369803229	NA	NA	NA	NA	0.845331163606509	NA	0.91804615626986	0.779151092808137	0.845331163606509	NA	NA	NA	NA	p.Asn292Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.714	-3.118	1.404	11.157	11.157	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.64	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N292W	292	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.714	-5.535	3.821	0.6	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N292X	292	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N292Y	292	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn292Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.714	-4.275	2.561	4.839	NA	83.37	0.003546179	0.018018018	0.101355692	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.985	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G293A	293	G	A	missense	wt-like	1.07536815636422	0.153172797920241	4	0.0765863989601203	0.925261572696772	1.22547474003168	NA	NA	NA	NA	1.15534010037724	0.847185964649416	1.12779431735666	1.17115224307358	0.847035458888754	NA	NA	NA	NA	0.811692436426239	0.70889656351533	0.895009840134501	0.882378481351269	p.Gly293Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	-9.4	1.8	-11.2	97	121	-24	9	8.1	0.9	75	89	-14	3.29	6	2.71	-1.713	-2.665	0.952	11.788	11.788	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.62	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
G293C	293	G	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	159	-9.4	2.5	-11.9	97	148	-51	9	5.5	3.5	75	121	-46	3.29	5.07	1.78	-1.713	-3.621	1.908	17.749	17.749	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G293D	293	G	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-9.4	-3.5	-5.9	97	187	-90	9	13	-4	75	133	-58	3.29	5.05	1.76	-1.713	-2.693	0.98	17.916	17.916	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G293E	293	G	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.5	-5.9	97	214	-117	9	12.3	-3.3	75	147	-72	3.29	3.22	-0.07	-1.713	-3.074	1.361	13.047	13.047	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.97	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G293F	293	G	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-9.4	2.8	-12.2	97	228	-131	9	5.2	3.8	75	165	-90	3.29	3.32	0.03	-1.713	-2.891	1.178	12.147	12.147	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293H	293	G	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-9.4	-3.2	-6.2	97	216	-119	9	10.4	-1.4	75	155	-80	3.29	7.59	4.3	-1.713	-3.224	1.511	14.671	14.671	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293I	293	G	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-9.4	4.5	-13.9	97	191	-94	9	5.2	3.8	75	131	-56	3.29	6.02	2.73	-1.713	-4.034	2.321	4.169	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293K	293	G	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	-3.9	-5.5	97	230	-133	9	11.3	-2.3	75	146	-71	3.29	9.74	6.45	-1.713	-3.775	2.062	4.351	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G293L	293	G	L	missense	wt-like	1.00783918786769	0.0737400610842267	8	0.0260710486188835	0.956740871535486	1.05893750419989	0.910378737713981	1.15013598932698	0.93368111102996	1.05646612669486	1.00893318083206	1.0043717907229	0.987214029062177	1.01153253755861	0.77269064664199	0.740249541847679	0.838416858215301	0.751977979468721	0.759012128844532	0.757003913750721	0.786369164439447	0.819294225688777	0.802209794402947	p.Gly293Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-9.4	3.8	-13.2	97	191	-94	9	4.9	4.1	75	131	-56	3.29	9.71	6.42	-1.713	-2.698	0.985	13.604	13.604	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.42	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293M	293	G	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-9.4	1.9	-11.3	97	203	-106	9	5.7	3.3	75	149	-74	3.29	5.74	2.45	-1.713	-4.828	3.115	1.806	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G293N	293	G	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-9.4	-3.5	-5.9	97	187	-90	9	11.6	-2.6	75	132	-57	3.29	5.47	2.18	-1.713	-2.923	1.21	15.797	15.797	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.275	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
G293P	293	G	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-9.4	-1.6	-7.8	97	154	-57	9	8	1	75	115	-40	3.29	6.3	3.01	-1.713	-2.998	1.285	41.248	41.248	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293Q	293	G	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-9.4	-3.5	-5.9	97	214	-117	9	10.5	-1.5	75	146	-71	3.29	6.24	2.95	-1.713	-3.333	1.62	10.298	10.298	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
G293R	293	G	R	missense	wt-like	1.16955216714077	0.117058692933942	6	0.0477890112742162	1.07588742618653	1.26321690809501	NA	1.39357084467274	1.18678553890372	NA	1.08803567327611	1.12220485902353	1.07574112211541	1.15097496485311	0.869609407834514	NA	0.95063622962844	0.876113669347246	NA	0.786551686937639	0.844445865781791	0.866974333098848	0.872244482570181	p.Gly293Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-9.4	-4.5	-4.9	97	265	-168	9	10.5	-1.5	75	174	-99	3.29	6.34	3.05	-1.713	-4.083	2.37	3.493	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00164757414083634	0.00143068548720921	0.00143068548720921	0.000951386083468591	0.00148297544192668	0.0018400282594598	0.00257797054494465	deleterious	deleterious	medium	2.62	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
G293S	293	G	S	missense	wt-like	1.0301990566201	0.40121079358893	7	0.151643426164454	0.732983402845516	1.32741471039469	1.21726721323489	0.210394439356857	1.02097108824932	NA	1.53032987426244	1.04271305566047	1.09239631807809	1.09732140749867	0.845297087639618	0.886259872409141	0.405211819114911	0.794789563733103	NA	0.95176530194323	0.805266526826602	0.875944711601604	0.845297087639618	p.Gly293Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-9.4	-0.8	-8.6	97	143	-46	9	9.2	-0.199999999999999	75	105	-30	3.29	5.68	2.39	-1.713	-2.371	0.658	8.349	8.349	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
G293T	293	G	T	missense	possibly_wt-like	0.845816985633236	0.611114809852887	3	0.352827299974331	0.154288184921037	1.53734578634544	1.36304862034741	0.171491067533206	NA	NA	1.00291126901909	NA	NA	NA	0.754754501893981	0.955619242799589	0.387278019430799	NA	NA	0.754754501893981	NA	NA	NA	p.Gly293Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-9.4	-0.7	-8.7	97	163	-66	9	8.6	0.4	75	119	-44	3.29	5.6	2.31	-1.713	-3.077	1.364	12.143	12.143	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
G293V	293	G	V	missense	wt-like	0.961489759848845	0.172950925159484	8	0.0611473859963792	0.841643085547172	1.08133643415052	0.69411146821545	0.752898902820064	0.938420865819254	1.10084532861997	1.14657737668646	0.904232679520775	1.14818737933216	1.00664407777662	0.766388650061151	0.6373546532224	0.655297246660587	0.754302603875993	0.778474696246309	0.808419227654749	0.737013331328699	0.905993408575265	0.79975457497589	p.Gly293Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-9.4	4.2	-13.6	97	165	-68	9	5.9	3.1	75	117	-42	3.29	5.61	2.32	-1.713	-3.745	2.032	3.532	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
G293W	293	G	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	184	-9.4	-0.9	-8.5	97	264	-167	9	5.4	3.6	75	204	-129	3.29	5.89	2.6	-1.713	-5.372	3.659	0.948	NA	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.97	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
G293X	293	G	X	nonsense	low	0.0975413414471363	0.109396792515896	6	0.0446610535268444	0.0100072850229057	0.185075397871367	NA	0.0814135459254243	0.240887770318916	0.213579451672969	0.0709589729056033	NA	-0.0371077147306014	0.0155160225905072	0.367558338192893	NA	0.345753797934574	0.412195779627847	0.389362878451211	0.406635065757783	NA	0.267601302290285	0.301962435054548	p.Gly293Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-9.4	NA	NA	97	NA	NA	9	NA	NA	75	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	2	0	1	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
G293Y	293	G	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gly293Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-9.4	-1.3	-8.1	97	255	-158	9	6.2	2.8	75	181	-106	3.29	5.66	2.37	-1.713	-3.337	1.624	10.947	10.947	83.37	0.002889227	0.009090909	0.082578907	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.62	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S294A	294	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.784	-2.226	0.442	26.019	26.019	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.285	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S294C	294	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.784	-5.063	3.279	1.925	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.43	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
S294D	294	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.784	-2.806	1.022	34.553	34.553	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S294E	294	S	E	missense	wt-like	1.13175504260039	0.0992200205493541	2	0.0701591493599168	0.994245636668982	1.26926444853179	NA	NA	1.06159589324047	1.2019141919603	NA	NA	NA	NA	0.818756350702545	NA	NA	0.814714099372883	0.822798602032206	NA	NA	NA	NA	p.Ser294Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.784	-2.785	1.001	12.015	12.015	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.395	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S294F	294	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.784	-4.387	2.603	2.04	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S294G	294	S	G	missense	possibly_wt-like	0.976203393719287	0.528425648476009	6	0.215728867627589	0.553382582743604	1.39902420469497	NA	1.00704450146025	1.04438537537413	1.00649009094375	1.65945922740996	0.0255488763036815	NA	1.11429229082395	0.789363624491326	NA	0.772454090475373	0.806273158507279	0.73709506134249	1	0.303934081592144	NA	0.853820680814735	p.Ser294Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.784	-2.669	0.885	43.901	43.901	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.428571428571429
S294H	294	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.784	-3.505	1.721	13.002	13.002	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S294I	294	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.784	-4.014	2.23	4.731	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.571428571428571
S294K	294	S	K	missense	possibly_wt-like	0.958907987733877	0.681604550832141	4	0.34080227541607	0.290947802069079	1.62686817339867	NA	1.33254518566917	1.22089663809521	1.34234443899875	NA	-0.0601543118276189	NA	NA	0.888614022620796	NA	0.922504427862721	0.892843541938655	0.884384503302936	NA	0.261693320717707	NA	NA	p.Ser294Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.784	-2.658	0.874	14.163	14.163	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.085	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S294L	294	S	L	missense	wt-like	0.969279215251367	0.173540677421841	7	0.0655922106874104	0.84072084463768	1.09783758586505	NA	0.986405439955172	1.10395751804695	1.2236578130602	0.875250916337134	0.961095911907876	0.962982412843398	0.67160449460883	0.765039665636488	NA	0.762939830467834	0.835490462567726	0.83233430057698	0.707068531079892	0.765039665636488	0.806243237294341	0.631481595323295	p.Ser294Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.784	-2.832	1.048	12.579	12.579	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S294M	294	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.784	-4.78	2.996	1.772	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S294N	294	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.784	-2.541	0.757	20.355	20.355	89.83	0.002850281	0.009174312	0.081465767	3.269e-05	1	30594	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.5
S294P	294	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.784	-4.001	2.217	2.611	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.43	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S294Q	294	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.784	-3.246	1.462	11.732	11.732	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S294R	294	S	R	missense	wt-like	0.924219315363497	0.203627176261854	6	0.0831304466008856	0.761286634007031	1.08715199671996	NA	1.00428392968323	1.075441281571	1.11766466593554	1.01059023820194	0.63297751566958	NA	0.704358261119697	0.764402200353138	NA	0.77118151334537	0.821504604171572	0.785850842548124	0.757622887360906	0.603319069049442	NA	0.647932110911684	p.Ser294Arg	1	0	NA	1.05507162053075	0.0239373109500297	0.852944093143215	1.25719914791828	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.784	-3.888	2.104	5.479	NA	89.83	0.002850281	0.009174312	0.081465767	6.866e-05	19	276736	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 4, 2017)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	1	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	neutral	neutral	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.5
S294S	294	S	S	synonymous	possibly_wt-like	0.8243934436611	0.293033267239136	5	0.131048461043114	0.567543179787196	1.081243707535	0.344281197246193	NA	NA	NA	1.06319692634646	0.748875042496447	0.987621338791903	0.977992713424503	0.77727347536872	0.470913624708942	NA	NA	NA	0.77727347536872	0.660441794859036	0.819513600018067	0.785364482900625	p.Ser294=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S294T	294	S	T	missense	wt-like	1.06159067173188	0.142715688717079	4	0.0713578443585394	0.921731866774725	1.20144947668903	NA	0.898246583537976	1.19519528995477	1.16626463886295	NA	NA	NA	0.986656174571811	0.798440062503248	NA	0.722300081334179	0.880238252457852	0.807164435578039	NA	NA	NA	0.789715689428458	p.Ser294Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.784	-2.189	0.405	21.967	21.967	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.74	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.428571428571429
S294V	294	S	V	missense	possibly_wt-like	0.78599081835538	0.327705210442101	5	0.146554225425882	0.498749814738486	1.07323182197227	0.320296309367443	0.9300703313086	1.0502587779775	1.06007281468923	NA	NA	NA	0.569255858434126	0.736970293476797	0.459502178248753	0.736970293476797	0.809153783276385	0.760593847423117	NA	NA	NA	0.580077191671469	p.Ser294Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.784	-3.667	1.883	6.39	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S294W	294	S	W	missense	wt-like	1.05466060996834	0.151378081158046	4	0.0756890405790232	0.906312816409064	1.20300840352762	NA	1.17498117186999	1.13003194392599	1.07814156695654	0.835487757120843	NA	NA	NA	0.808398327760844	NA	0.849870069234163	0.848278728944063	0.768517926577625	0.692215486966909	NA	NA	NA	p.Ser294Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.784	-5.554	3.77	0.502	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S294X	294	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser294Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S294Y	294	S	Y	missense	possibly_wt-like	0.950080919753577	0.324417381274922	3	0.18730246240887	0.582974839216525	1.31718700029063	NA	0.5941635954946	1.0268527201246	1.22922644364153	NA	NA	NA	NA	0.797674224568884	NA	0.582122941428764	0.797674224568884	0.834776432100829	NA	NA	NA	NA	p.Ser294Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.784	-4.391	2.607	2.131	NA	89.83	0.002850281	0.009174312	0.081465767	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.43	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L295A	295	L	A	missense	wt-like	1.0334773600348	0.239441944274854	8	0.0846555112486204	0.867555606894674	1.19939911317492	0.829907854551672	1.23098844222234	0.961867117090177	0.654259760734853	1.3871998914175	1.07845219845151	1.20938220942998	0.915761406380334	0.794341624908031	0.701963385187159	0.875688478288935	0.765801875544338	0.582623907169684	0.89830083908397	0.822881374271723	0.938952539744864	0.75410892985526	p.Leu295Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.65	-2.656	1.006	23.647	23.647	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.36	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L295C	295	L	C	missense	wt-like	0.948287552239905	0.210084966180713	8	0.0742762521058645	0.802708773205794	1.09386633127402	1.0227142088785	0.921099785361614	0.917344287926505	0.799283552223207	1.34724843375592	0.834208013857907	1.09100399224605	0.653398143669544	0.738400283558236	0.793696121262785	0.732835022765568	0.743965544350904	0.64622431443852	0.883377458378788	0.702500085998245	0.875194814107718	0.622337490939604	p.Leu295Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.65	-5.017	3.367	1.749	NA	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L295D	295	L	D	missense	possibly_wt-like	0.974849969483326	0.402571211722429	7	0.152157615887354	0.676626522370633	1.27307341659602	NA	1.29165710610192	1.13073307169622	1.37375272498326	0.186214034451285	1.02767693901176	0.741676689711265	1.07223922042757	0.832699607918713	NA	0.903655711310568	0.848622598785386	0.898158655528096	0.449687191069828	0.797855635567045	0.687049437007032	0.832699607918713	p.Leu295Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.65	-3.179	1.529	11.518	11.518	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
L295E	295	L	E	missense	possibly_wt-like	0.92785113239992	0.318777487078486	4	0.159388743539243	0.615454935521913	1.24024732927793	0.971337402146821	NA	NA	NA	0.467806350517571	1.08835746311083	NA	1.18390331382446	0.798507825857613	0.769252243005865	NA	NA	NA	0.554872573087862	0.827763408709361	NA	0.888782681860129	p.Leu295Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.65	-3.801	2.151	3.509	NA	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.91	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
L295F	295	L	F	missense	possibly_wt-like	0.877125149022678	0.262810073235303	4	0.131405036617651	0.619576009864914	1.13467428818044	1.11051482958638	NA	1.05253987777965	NA	0.534148395502684	NA	NA	0.811297493221998	0.755957343369821	0.835469594936891	NA	0.810272554291182	NA	0.579653836451505	NA	NA	0.70164213244846	p.Leu295Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.65	-3.015	1.365	31.946	31.946	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.71	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
L295G	295	L	G	missense	wt-like	1.0535422223871	0.147703620705546	8	0.0522211159033486	0.951190715984043	1.15589372879015	1.1352955979561	0.862472840305554	1.08543490377076	0.974485061029842	1.21695367240128	1.27485205922382	0.955668953659721	0.923174690749711	0.814355128642972	0.847259702646503	0.705808987760355	0.82640600078709	0.723059206147384	0.834707436272039	0.91968150196296	0.802304256498855	0.757832237525513	p.Leu295Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.65	-3.006	1.356	26.062	26.062	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
L295H	295	L	H	missense	wt-like	1.15935016779341	0.0723242225321808	3	0.041756409347885	1.07750910934785	1.24119122623898	NA	1.21521326116891	1.18517993864694	1.07765730356438	NA	NA	NA	NA	0.868416385312647	NA	0.868416385312647	0.875326198747782	0.768305552120643	NA	NA	NA	NA	p.Leu295His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.65	-3.535	1.885	14.759	14.759	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L295I	295	L	I	missense	wt-like	1.15035776669198	0.0474774032389568	3	0.0274110915404361	1.09663301449579	1.20408251888816	NA	NA	NA	NA	1.20354261932191	1.13528195473902	1.11224872601499	NA	0.850891209124258	NA	NA	NA	NA	0.829697900638671	0.850891209124258	0.88663708734934	NA	p.Leu295Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.65	-2.637	0.987	23.245	23.245	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
L295K	295	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.65	-3.111	1.461	13.682	13.682	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.91	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L295L	295	L	L	synonymous	wt-like	1.05586319776448	0.099734533567333	6	0.0407164528290745	0.976060416641265	1.13566597888769	NA	0.963932594717643	1.12043762292355	0.922319033275651	1.1332928939988	1.16760108384807	1.02759595782314	NA	0.822250318281025	NA	0.752580227021407	0.843573170583989	0.70018171427716	0.803456970850535	0.866820425226158	0.841043665711514	NA	p.Leu295=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L295M	295	L	M	missense	wt-like	1.0567016298769	0.124183726297624	8	0.0439055774890321	0.970648279277962	1.14275498047583	0.771865830685898	1.10934371393334	1.18028284299027	1.12774975859972	1.08529125288608	1.10058377953398	1.02553410635847	1.05296175402743	0.821314921825428	0.674348353124736	0.819612305774835	0.872924406124678	0.790273675479209	0.785526542107071	0.833789426173431	0.839933166135526	0.82301753787602	p.Leu295Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.65	-3.44	1.79	5.024	5.024	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L295N	295	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.65	-3.22	1.57	12.889	12.889	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L295P	295	L	P	missense	possibly_wt-like	0.790698909390657	0.592431248404529	2	0.418912153133655	-0.0303538234374339	1.61175164221875	NA	NA	NA	NA	0.371786756257002	NA	NA	1.20961106252431	0.710349985566177	NA	NA	NA	NA	0.519005622438764	NA	NA	0.901694348693589	p.Leu295Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.65	-3.248	1.598	25.166	25.166	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.015	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
L295Q	295	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.65	-4.21	2.56	2.629	NA	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
L295R	295	L	R	missense	wt-like	1.01980419247168	0.0816205708481993	8	0.0288572295655394	0.963245061829619	1.07636332311374	1.06238346618641	1.00331812191538	1.16538937725937	0.921798335379454	0.907512390729011	1.05237286903157	1.02830542312947	1.01735355614278	0.807580487351981	0.812569822410486	0.770736292218509	0.865619869184262	0.699953361412279	0.719119412140069	0.810027585027555	0.841425779037985	0.805133389676408	p.Leu295Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.65	-3.262	1.612	16.562	16.562	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.255	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
L295S	295	L	S	missense	possibly_wt-like	0.841945109239677	0.255591614057273	6	0.104344839495781	0.637432981855334	1.04645723662402	NA	1.05067096685898	1.13704085701705	0.949126306989047	0.438788623686696	0.751519635872353	NA	0.724524265013939	0.686841664094924	NA	0.792565156810015	0.851716267627864	0.711938085479715	0.544033354444971	0.661745242710132	NA	0.658060447184328	p.Leu295Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.65	-2.84	1.19	11.296	11.296	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.71	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L295T	295	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.65	-3.024	1.374	13.424	13.424	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.91	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
L295V	295	L	V	missense	possibly_wt-like	0.74309013596737	0.652617012364144	7	0.24666604515507	0.259633571254502	1.22654670068024	NA	1.14320756737458	1.05738409809714	1.21241743386565	-0.292809331317401	1.40117623945596	-0.0101496895914371	0.690404633887105	0.812648414073987	NA	0.835222972297527	0.812648414073987	0.827404814957463	0.270753843641118	0.981943240483939	0.282120716515552	0.640923928746492	p.Leu295Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.65	-2.42	0.77	24.384	24.384	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.76	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
L295W	295	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.65	-5.427	3.777	1.484	NA	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.255	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L295X	295	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu295Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L295Y	295	L	Y	missense	possibly_wt-like	0.922578338458676	0.279380729773111	3	0.1613005395409	0.606435090271634	1.23872158664572	NA	1.13596005713021	0.606352819051736	1.02542213919408	NA	NA	NA	NA	0.74539774028087	NA	0.831881992047277	0.591439012676161	0.74539774028087	NA	NA	NA	NA	p.Leu295Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.65	-4.188	2.538	7.409	NA	90.57	0.003506485	0	0.100221187	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.255	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C296A	296	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.459	-2.526	0.067	26.235	26.235	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.155	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296D	296	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.459	-3.169	0.71	14.373	14.373	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296E	296	C	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.459	-3.736	1.277	4.534	NA	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296F	296	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.459	-3.367	0.908	32.233	32.233	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	0.95	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.5
C296G	296	C	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.459	-2.989	0.53	27.833	27.833	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
C296H	296	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.459	-3.019	0.56	18.185	18.185	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C296I	296	C	I	missense	wt-like	1.00353298134953	0.12517464391347	5	0.0559798025699697	0.893814584450728	1.11325137824833	0.79749494579327	1.02259000583352	1.12353287835463	1.07712786193629	NA	NA	NA	0.996919214829948	0.779620306367464	0.686542084291973	0.779620306367464	0.845091246231716	0.768073364678666	NA	NA	NA	0.794870281456667	p.Cys296Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.459	-3.775	1.316	14.871	NA	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296K	296	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.459	-3.13	0.671	9.83	8.732	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296L	296	C	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.459	-2.627	0.168	34.104	34.104	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296M	296	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.459	-4.685	2.226	4.526	NA	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
C296N	296	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.459	-3.217	0.758	28.45	28.45	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.95	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296P	296	C	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.459	-3.013	0.554	43.212	43.212	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C296Q	296	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.459	-3.352	0.893	5.999	5.999	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296R	296	C	R	missense	wt-like	0.936433530733162	0.151938073429802	4	0.0759690367149012	0.787536954831754	1.08533010663457	0.989993587831253	0.860763938060031	0.773683017071383	NA	NA	NA	NA	1.12129357996998	0.741574815335621	0.778128418086002	0.70502121258524	0.673506520317865	NA	NA	NA	NA	0.857337064684581	p.Cys296Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.459	-3.287	0.828	28.001	28.001	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jun 22, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	D	0.357142857142857
C296S	296	C	S	missense	possibly_wt-like	0.897460145428087	0.438877354856281	2	0.310333153728091	0.289218340912297	1.50570194994388	NA	NA	NA	NA	NA	1.20779329915618	NA	0.587126991699996	0.737841502065745	NA	NA	NA	NA	NA	0.886630070501463	NA	0.589052933630026	p.Cys296Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.459	-2.543	0.084	19.318	19.318	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
C296T	296	C	T	missense	wt-like	0.963207445534079	0.228321691889977	7	0.0862974879517704	0.79406747719233	1.13234741387583	0.965767192564902	0.872025186094293	1.07029155695765	0.896725604479016	0.561257134461695	1.30171886262349	NA	1.07466658155751	0.766602068081661	0.766602068081661	0.710212458407196	0.818978909054611	0.688957676633635	0.589779975911786	0.932923415625816	NA	0.833918745329776	p.Cys296Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.459	-2.683	0.224	9.641	9.641	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296V	296	C	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.459	-2.41	-0.049	24.384	24.384	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C296W	296	C	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.459	-3.66	1.201	29.078	29.078	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.155	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.714285714285714
C296X	296	C	X	nonsense	low	0.00949226826397626	0.114191159245176	2	0.080745343053817	-0.148765696040836	0.167750232568789	NA	-0.0712530747898407	NA	0.0902376113177932	NA	NA	NA	NA	0.305324089682465	NA	0.275377055096734	NA	0.335271124268195	NA	NA	NA	NA	p.Cys296Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C296Y	296	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys296Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.459	-4.218	1.759	7.476	NA	86.35	0.00407253	0.009345794	0.116399696	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: May 18, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.5	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	D	D	D	D	B	0.428571428571429
D297A	297	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-2.011	-2.894	0.883	10.997	10.997	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	0.99	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D297C	297	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-2.011	-5.257	3.246	1.634	NA	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D297E	297	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-2.011	-2.618	0.607	26.905	26.905	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.785	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D297F	297	D	F	missense	wt-like	0.904039370537377	0.176606589226406	6	0.0720993381363339	0.762727264480987	1.04535147659377	NA	1.07772600059973	0.977375667970391	0.861971811502535	0.647850798652254	NA	1.09041898782394	0.768892956675414	0.726876309436097	NA	0.805037072040211	0.773408082510783	0.673716347161025	0.622125985119229	NA	0.874879734591161	0.680344536361411	p.Asp297Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-2.011	-4.381	2.37	4.888	NA	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D297G	297	D	G	missense	wt-like	1.09446452954357	0.186175188840446	4	0.0930875944202232	0.912016197072458	1.27691286201468	NA	1.18947214334676	NA	NA	1.18045328309583	0.815308921014147	1.19262377071752	NA	0.838811661675938	NA	0.856550163208295	NA	NA	0.821073160143581	0.693185239270093	0.929926555379216	NA	p.Asp297Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-2.011	-2.583	0.572	44.786	44.786	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
D297H	297	D	H	missense	wt-like	1.07733407224445	0.236688458324199	7	0.0894598284178723	0.901996030482289	1.25267211400661	NA	1.00033022066784	0.971724350055184	1.3786233364531	1.11217136374688	1.40469922761549	0.883084056470676	0.790705950701989	0.770636379723833	NA	0.769358920028457	0.770636379723833	0.900294669694813	0.795567280324213	0.983679625134907	0.763210510449367	0.691300070227861	p.Asp297His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-2.011	-2.989	0.978	19.415	19.415	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Dec 22, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D297I	297	D	I	missense	wt-like	1.14228512098721	0.212558412378445	2	0.150301494791045	0.847699604374224	1.43687063760019	NA	NA	0.991983626196162	1.29258661577825	NA	NA	NA	NA	0.821567862417399	NA	NA	0.780572591592296	0.862563133242502	NA	NA	NA	NA	p.Asp297Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-2.011	-4.079	2.068	14.382	NA	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D297K	297	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-2.011	-2.538	0.527	24.201	24.201	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D297L	297	D	L	missense	wt-like	1.23695431895789	0.180809595148743	4	0.0904047975743713	1.05976417168249	1.4141444662333	NA	1.34975759201406	1.14071582421092	1.42354715510143	NA	NA	NA	1.03379670450517	0.886757371968512	NA	0.930439057510507	0.8535186643371	0.919996079599924	NA	NA	NA	0.813391928991817	p.Asp297Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-2.011	-3.101	1.09	15.561	15.561	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D297M	297	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-2.011	-4.864	2.853	2.778	NA	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D297N	297	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-2.011	-2.724	0.713	28.45	28.45	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D297P	297	D	P	missense	wt-like	0.948532867460711	0.252169567182552	6	0.102947794709289	0.746758897542681	1.15030683737874	1.08356247987281	0.890225385746105	1.14733798994743	1.14741937956258	NA	0.940128478951425	NA	0.482523490683917	0.776802604310307	0.822646299815083	0.718602444145348	0.856766521828561	0.798899818067421	NA	0.754705390553193	NA	0.536516028492898	p.Asp297Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-2.011	-2.984	0.973	43.09	43.09	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D297Q	297	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-2.011	-3.252	1.241	18.792	18.792	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D297R	297	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-2.011	-2.805	0.794	17.501	17.501	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D297S	297	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-2.011	-2.803	0.792	19.646	19.646	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D297T	297	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-2.011	-2.87	0.859	20.381	20.381	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D297V	297	D	V	missense	wt-like	1.04117571136974	0.207323608222122	6	0.0846395086294809	0.87528532278679	1.20706609995269	NA	0.88372911432926	0.884425793918364	1.02719685442971	1.14373106248724	1.40833805572405	NA	0.899633387329814	0.746092354003545	NA	0.715607772351565	0.727820587908258	0.746176044382657	0.807356021632046	0.985473104133158	NA	0.746008663624432	p.Asp297Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-2.011	-3.155	1.144	23.583	23.583	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
D297W	297	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-2.011	-5.539	3.528	1.023	NA	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D297X	297	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D297Y	297	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp297Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-2.011	-3.389	1.378	11.814	11.814	85.11	0.003470154	0.009433962	0.099182772	0	NA	NA	not specified	Uncertain significance(Last reviewed: Aug 31, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	medium	2.14	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Q298A	298	Q	A	missense	possibly_wt-like	0.796830086433121	0.24480570528455	7	0.092527859387527	0.615478814466982	0.97818135839926	0.617901694146611	0.759388391906434	0.967702936726629	0.829353464840172	0.360848399947776	1.07153672199943	NA	0.971078995464798	0.659411520960636	0.601095832212853	0.658288791914164	0.768664067654777	0.659411520960636	0.514919732585277	0.819472924790268	NA	0.781892081488955	p.Gln298Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-2.296	-2.558	0.262	26.019	26.019	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q298C	298	Q	C	missense	wt-like	0.984902542588485	0.275845915834734	6	0.112613623570969	0.764183896220835	1.20562118895614	0.62389892189599	NA	0.783595674435811	1.38976214816395	0.912497671154468	NA	1.016056386148	1.18360445373269	0.777905065805399	0.60394917235426	NA	0.67836820753053	0.905179612737818	0.720981602960273	NA	0.834828528650524	0.888632579959732	p.Gln298Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-2.296	-3.649	1.353	17.749	17.749	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.075	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Q298D	298	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-2.296	-2.696	0.4	20.377	20.377	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q298E	298	Q	E	missense	possibly_wt-like	0.772931322570872	0.318968291347572	4	0.159484145673786	0.460348140945112	1.08551450419663	NA	0.906367619590925	0.943647524005456	0.946445824673188	0.295264322013919	NA	NA	NA	0.718403149055026	NA	0.726043742281134	0.756866031253199	0.710762555828919	0.490421598587368	NA	NA	NA	p.Gln298Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-2.296	-2.513	0.217	27.568	27.568	92.8	0.003091843	0.00952381	0.088370032	1.808e-05	5	276588	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Dec 19, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	2	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
Q298F	298	Q	F	missense	wt-like	0.880147320263429	0.095136629838895	5	0.0425463942940008	0.796757919775147	0.963536720751711	0.918661698089444	0.979230498070757	0.747514324338017	0.938077145529179	NA	NA	NA	0.81725293528975	0.70709245869245	0.744190379900968	0.759632303010226	0.660672020530703	0.70709245869245	NA	NA	NA	0.70463324165536	p.Gln298Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-2.296	-4.412	2.116	4.891	NA	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q298G	298	Q	G	missense	wt-like	1.00545115616781	0.240629183460693	8	0.0850752636882189	0.838706703363653	1.17219560897197	1.10052206166429	0.975879358207142	1.18418282324003	1.23946885171754	0.979870912505896	0.454994014279362	1.06565531480442	1.0430359129238	0.824373787034561	0.830715270601147	0.758087483931305	0.874837161041231	0.83926825594823	0.74614805717444	0.51559586194656	0.861542183919203	0.818032303467976	p.Gln298Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-2.296	-2.977	0.681	25.177	25.177	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q298H	298	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-2.296	-3.544	1.248	31.538	31.538	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
Q298I	298	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-2.296	-3.968	1.672	14.463	NA	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q298K	298	Q	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-2.296	-2.833	0.537	25.095	25.095	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
Q298L	298	Q	L	missense	possibly_low	0.571208491279465	0.369707376862172	7	0.139736253863335	0.297330466372783	0.845086516186147	0.834517072649679	0.633004656991141	0.741539452592757	0.302090281544918	-0.0562654153648897	0.479103325934574	NA	1.06447006460807	0.600028017100734	0.704156342928493	0.600028017100734	0.657741629971106	0.428179439305026	0.359111944142872	0.527478683235715	NA	0.828797564504107	p.Gln298Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-2.296	-2.681	0.385	33.545	33.545	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
Q298M	298	Q	M	missense	wt-like	0.96247383751784	0.314171295725099	8	0.111076326830691	0.744768237394686	1.18017943764099	1.22025495781354	0.977986075395253	1.06490571036509	1.01863435961583	1.23499825995176	0.286266129057037	1.14669441026323	0.750050797680976	0.787698026215718	0.887681371124011	0.759058645099903	0.816337407331533	0.742420949085459	0.841447772305957	0.432434495281803	0.905189305298955	0.670881098617417	p.Gln298Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-2.296	-3.583	1.287	8.28	8.28	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q298N	298	Q	N	missense	wt-like	1.06981376188724	0.072599248077611	2	0.0513354206247232	0.969198186331568	1.17042933744291	NA	NA	NA	NA	1.01847834126252	NA	NA	1.12114918251196	0.808916966792032	NA	NA	NA	NA	0.760569392242202	NA	NA	0.857264541341861	p.Gln298Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-2.296	-2.944	0.648	28.057	28.057	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q298P	298	Q	P	missense	wt-like	1.0217728684322	0.155056481941052	2	0.109641489847447	0.806879497119891	1.23666623974451	NA	NA	1.13141435827965	NA	NA	0.912131378584755	NA	NA	0.794931560925759	NA	NA	0.848956737467784	NA	NA	0.740906384383733	NA	NA	p.Gln298Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-2.296	-3.245	0.949	44.931	44.931	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
Q298Q	298	Q	Q	synonymous	wt-like	1.23395123314079	0.391319226290013	3	0.225928260637615	0.791139979201289	1.6767624870803	NA	NA	NA	NA	1.65945922740996	NA	0.889523597892926	1.15287087411949	0.873196699315406	NA	NA	NA	NA	1	NA	0.766678804912621	0.873196699315406	p.Gln298=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	NA	NA	NA	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q298R	298	Q	R	missense	wt-like	1.06937804594966	0.14797862821015	7	0.0559306642280776	0.959755958431222	1.17900013346809	NA	0.970725592978899	1.14632143392842	0.803133898859597	1.24519733130386	1.0319170820412	1.11826749462991	1.17008348790571	0.845257511262565	NA	0.755711684896681	0.856267949425934	0.647912889890088	0.845257511262565	0.79994548626788	0.889878756358659	0.881841701144833	p.Gln298Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-2.296	-2.809	0.513	28.77	28.77	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
Q298S	298	Q	S	missense	wt-like	0.982548947535801	0.337451227453993	8	0.119307025626221	0.748711474205811	1.21638642086579	1.26962922262855	0.405631253754472	0.616374671968902	0.936090360167087	1.10011699014739	1.36067005795415	0.902302410679562	1.2695766129863	0.782312952422495	0.911172486958952	0.49521270480273	0.596354255116543	0.706221150909858	0.791064515796532	0.961978849846181	0.773561389048458	0.931811929897995	p.Gln298Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-2.296	-2.529	0.233	17.954	17.954	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.03	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Q298T	298	Q	T	missense	possibly_wt-like	0.953947110755044	0.354932910676057	7	0.134152030537307	0.691013962449004	1.21688025906108	NA	0.955103647129417	0.998167009026484	1.10850908382812	1.17250006986675	0.169711298201473	1.14990330414269	1.12373536309037	0.783605246926987	NA	0.748510230770529	0.783605246926987	0.781835647904272	0.818102334151386	0.374987802267447	0.906917594340912	0.858563445512327	p.Gln298Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-2.296	-2.865	0.569	20.015	20.015	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q298V	298	Q	V	missense	possibly_wt-like	0.724168326507491	0.419604591706795	6	0.171302857235086	0.388420895877916	1.05991575713707	NA	1.04554566764367	1.1085017604472	1.06244123286751	0.609396087289785	0.0724445880663272	NA	0.446680622730454	0.684697108320271	NA	0.790202480128281	0.837719197442372	0.761632520865424	0.607761695775118	0.327047697197291	NA	0.518514017707196	p.Gln298Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-2.296	-3.103	0.807	23.716	23.716	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q298W	298	Q	W	missense	wt-like	1.01021073967102	0.254281039880263	6	0.103809799828491	0.806747270764866	1.21367420857717	1.0956120353904	NA	1.08506823518936	1.23404189148587	1.21913257437992	NA	0.856563186991398	0.570846514589166	0.827302681335764	0.828379195393046	NA	0.826226167278482	0.836888254174566	0.83552133858374	NA	0.748926545374178	0.580876095634638	p.Gln298Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-2.296	-5.544	3.248	0.661	NA	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.075	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Q298X	298	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	4	1	0	0	1	2	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q298Y	298	Q	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln298Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-2.296	-4.372	2.076	5.17	NA	92.8	0.003091843	0.00952381	0.088370032	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E299A	299	E	A	missense	wt-like	0.910230332847785	0.104183403780754	3	0.0601503162179096	0.792337879401986	1.02812278629358	NA	0.814893867385229	1.02143910687494	0.894358024283181	NA	NA	NA	NA	0.687919370689821	NA	0.683875881977215	0.79501910462046	0.687919370689821	NA	NA	NA	NA	p.Glu299Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.853	-2.835	0.982	15.885	15.885	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E299C	299	E	C	missense	wt-like	1.00420974485689	0.147210318009149	4	0.0736051590045744	0.859946284131576	1.1484732055822	NA	NA	1.19594798511882	1.03060435225095	0.851776078243717	0.938510563814051	NA	NA	0.750789186085546	NA	NA	0.88060741365445	0.747670407803823	0.698299791054733	0.75390796436727	NA	NA	p.Glu299Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.853	-5.229	3.376	1.615	NA	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E299D	299	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.853	-2.457	0.604	35.636	35.636	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.04	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
E299F	299	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.853	-4.353	2.5	5.051	NA	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E299G	299	E	G	missense	possibly_wt-like	0.849213232570376	0.256648439302022	7	0.0970039921094295	0.659088901679286	1.03933756346146	NA	0.978711413038984	1.12887945344334	1.13251051859955	0.635820523968537	0.878218724227242	0.445973782421617	0.74437821229336	0.724191763206065	NA	0.759393013546551	0.847713487149031	0.792361514114452	0.617632222448195	0.724191763206065	0.527785804883001	0.668032053628515	p.Glu299Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.853	-2.724	0.871	44.786	44.786	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.14	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E299H	299	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.853	-4.658	2.805	2.674	NA	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E299I	299	E	I	missense	wt-like	0.929239362373982	0.1391734919319	4	0.0695867459659501	0.792851846479382	1.06562687826858	NA	NA	NA	NA	0.999705960935308	1.08823265420632	0.842235339698602	0.786783494655693	0.747383429781739	NA	NA	NA	NA	0.75355719807551	0.827701893808865	0.741209661487967	0.689330024300076	p.Glu299Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.853	-3.997	2.144	13.404	NA	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E299K	299	E	K	missense	wt-like	1.02483519233062	0.11498916947666	7	0.0434618208430145	0.93965158877578	1.11001879588546	NA	1.02202010113172	1.17009152948554	1.09221809583887	0.852747009926632	1.1058866364476	0.893162973231352	1.03772000025263	0.779357589891183	NA	0.779357589891183	0.867926051321857	0.77469121001381	0.698662470766337	0.836403059525041	0.768638948424137	0.815362396657879	p.Glu299Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.853	-2.968	1.115	11.482	11.482	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E299L	299	E	L	missense	wt-like	0.859088221715284	0.110175214903513	5	0.0492718539919806	0.762517162439486	0.955659280991082	0.863267653350887	0.880650102252701	0.71284013937368	0.820795964688406	NA	1.01788724891075	NA	NA	0.714188399602687	0.717835194129706	0.714188399602687	0.643665981135492	0.655658616080204	NA	0.793030564672853	NA	NA	p.Glu299Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.853	-3.02	1.167	16.446	14.722	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E299M	299	E	M	missense	wt-like	0.948678830628238	0.114189887894461	6	0.0466178265211738	0.857309569609201	1.04004809164727	NA	0.831306784128459	1.01104015941012	1.09699629264327	NA	0.925763802347599	0.807344254523803	1.01962169071617	0.762206064670644	NA	0.691441960373694	0.789918915230649	0.776786695586566	NA	0.747625433754721	0.722417553542122	0.806272555858832	p.Glu299Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.853	-3.559	1.706	13.504	13.504	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E299N	299	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.853	-2.885	1.032	26.249	26.249	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E299P	299	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.853	-2.939	1.086	43.458	43.458	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.59	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E299Q	299	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu299Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.853	-3.181	1.328	18.686	18.686	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
E299R	299	E	R	missense	possibly_low	0.644803787720266	0.346812318681152	8	0.122616671169236	0.404479528324372	0.88512804711616	0.702822024909983	0.550410636855686	0.312682023030267	0.035819754535785	0.941200768604932	1.05052817932769	0.952974004884254	0.611992909613529	0.621520362075309	0.641498931563854	0.561953563839223	0.447407447651615	0.311406089307288	0.7317032956279	0.809118387851019	0.800852774894216	0.601541792586764	p.Glu299Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.853	-2.77	0.917	17.501	17.501	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E299S	299	E	S	missense	wt-like	1.06801195756544	0.197833685072114	7	0.0747741045217549	0.921457405726565	1.21456650940431	0.764270018792997	1.12190380603195	1.09033074388785	0.866383742106215	1.11636059879482	1.36720017543598	NA	1.14963461790826	0.825402296851484	0.670734444184419	0.825402296851484	0.828807177627714	0.675651206126966	0.797132118083411	0.96519736641536	NA	0.87157129592147	p.Glu299Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.853	-2.612	0.759	19.482	19.482	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E299T	299	E	T	missense	possibly_wt-like	0.800194829658656	0.139370856080549	4	0.0696854280402746	0.66361390045246	0.936775758864852	NA	0.749761897797602	0.87313293357532	0.947302619941009	0.630581867320694	NA	NA	NA	0.682494722426881	NA	0.653851140139643	0.72228197674621	0.71113830471412	0.61567538602431	NA	NA	NA	p.Glu299Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.853	-2.822	0.969	20.564	20.564	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E299V	299	E	V	missense	possibly_low	0.652059655705643	0.335060616879363	7	0.126641009484955	0.403847838149336	0.90027147326195	NA	0.690125441269906	0.818394010047852	0.911964458644908	0.0687643333522883	0.299315528468778	0.865583016854478	0.910270801301291	0.695435136916607	NA	0.626359737335637	0.695435136916607	0.695640699614309	0.405815284866628	0.438866187872537	0.753784566143408	0.751351284122745	p.Glu299Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.853	-3.08	1.227	21.979	21.979	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E299W	299	E	W	missense	possibly_wt-like	1.04876213643689	0.405031600439262	4	0.202515800219631	0.651838461706104	1.44568581116767	NA	NA	NA	NA	1.49134443551904	0.510168598596281	1.06865527980726	1.12488023182498	0.861148199429197	NA	NA	NA	NA	0.937202765846189	0.542789907737562	0.863157945248628	0.859138453609765	p.Glu299Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.853	-5.497	3.644	1.057	NA	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E299X	299	E	X	nonsense	low	0.15695305851482	0.198500902274683	8	0.0701806670350382	0.0194014787151482	0.294504638314493	-0.00923012261549544	0.201933286198755	0.595393093893538	0.249900529225229	0.0962773078211274	0.016020024191794	0.0500481522078259	0.0552821971957902	0.361623144444755	0.302721239567691	0.401311369906503	0.586063788485811	0.405291542990038	0.416092421581097	0.299237570619303	0.314542876374763	0.321934918983007	p.Glu299Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	2	1	2	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E299Y	299	E	Y	missense	wt-like	1.13391133412484	0.0780155448052941	3	0.0450422957943119	1.04563005658699	1.2221926116627	NA	1.04574281035208	1.16199063449722	1.19400055752524	NA	NA	NA	NA	0.819328065454162	NA	0.790293359599031	0.863952947427721	0.819328065454162	NA	NA	NA	NA	p.Glu299Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.853	-3.375	1.522	12.208	12.208	42.68	0.003240968	0.019230769	0.092632271	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I300A	300	I	A	missense	wt-like	1.28691019972051	0.113922452522164	2	0.0805553387078246	1.12902463709075	1.44479576235028	NA	NA	NA	NA	1.36746553842834	NA	1.20635486101269	NA	0.914125670814122	NA	NA	NA	NA	0.890929311738901	NA	0.937322029889343	NA	p.Ile300Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.084	-2.533	0.449	25.444	25.444	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I300C	300	I	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.084	-3.597	1.513	26.503	26.503	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I300D	300	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.084	-3.135	1.051	21.657	21.657	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.43	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I300E	300	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.084	-2.899	0.815	25.947	25.947	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I300F	300	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.084	-3.338	1.254	32.042	32.042	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
I300G	300	I	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.084	-3.014	0.93	43.648	43.648	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I300H	300	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.084	-3.566	1.482	31.099	31.099	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I300K	300	I	K	missense	wt-like	1.19097183212933	0.407456365787072	3	0.235245042470193	0.729900021346152	1.6520436429125	NA	NA	0.994282899403512	NA	1.65945922740996	NA	NA	0.919173369574504	0.781700275798422	NA	NA	0.781700275798422	NA	1	NA	NA	0.75582258173997	p.Ile300Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.084	-3.796	1.712	8.075	NA	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I300L	300	I	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.084	-2.291	0.207	34.104	34.104	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.17	Neutral	TOLERATED	neutral	DAMAGING	null	D	N	T	T	D	B	0.214285714285714
I300M	300	I	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.084	-4.585	2.501	4.526	NA	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	N	T	D	D	B	0.428571428571429
I300N	300	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.084	-3.23	1.146	25.856	25.856	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
I300P	300	I	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.084	-2.802	0.718	41.371	41.371	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I300Q	300	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.084	-3.099	1.015	19.111	19.111	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I300R	300	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.084	-4.111	2.027	6.482	NA	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I300S	300	I	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.084	-2.68	0.596	19.755	19.755	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.63	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
I300T	300	I	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.084	-2.679	0.595	20.015	20.015	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
I300V	300	I	V	missense	possibly_low	0.329428114069465	0.738577978419053	2	0.522253496975164	-0.694169930801954	1.35302615894088	NA	NA	NA	NA	-0.192825382905699	NA	NA	0.851681611044629	0.515013303842448	NA	NA	NA	NA	0.308101630527748	NA	NA	0.721924977157147	p.Ile300Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.084	-2.716	0.632	23.783	23.783	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	null	D	N	T	D	D	B	0.285714285714286
I300W	300	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.084	-5.506	3.422	1.489	NA	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.78	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I300X	300	I	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I300Y	300	I	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile300Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.084	-4.266	2.182	7.431	NA	86.35	0.00323967	0.009708738	0.092595177	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D301A	301	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.731	-2.839	1.108	13.728	13.728	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D301C	301	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.731	-5.193	3.462	1.601	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D301E	301	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.731	-2.699	0.968	26.315	26.315	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
D301F	301	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.731	-4.403	2.672	4.32	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D301G	301	D	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.731	-2.682	0.951	45.546	45.546	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D301H	301	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.731	-3.473	1.742	13.441	13.441	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D301I	301	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.731	-3.24	1.509	11.589	11.589	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D301K	301	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.731	-3.021	1.29	10.863	10.863	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D301L	301	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.731	-2.654	0.923	29.631	29.631	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D301M	301	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.731	-4.794	3.063	3.933	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D301N	301	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.731	-2.84	1.109	28.293	28.293	42.68	0.002903035	0	0.082973577	8.13e-06	2	246002	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Sep 13, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D301P	301	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.731	-2.714	0.983	43.458	43.458	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D301Q	301	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.731	-2.79	1.059	19.004	19.004	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D301R	301	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.731	-3.963	2.232	6.446	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D301S	301	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.731	-2.454	0.723	19.318	19.318	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D301T	301	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.731	-3.008	1.277	11.838	11.838	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
D301V	301	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.731	-3.681	1.95	7.562	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.14	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D301W	301	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.731	-5.596	3.865	0.59	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.14	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D301X	301	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D301Y	301	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp301Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.731	-4.403	2.672	2.203	NA	42.68	0.002903035	0	0.082973577	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.14	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S302A	302	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.978	-2.608	0.63	25.875	25.875	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S302C	302	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.978	-3.575	1.597	19.068	19.068	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S302D	302	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.978	-2.807	0.829	32.387	32.387	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S302E	302	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.978	-2.79	0.812	25.873	25.873	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S302F	302	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.978	-4.386	2.408	4.538	NA	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S302G	302	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.978	-2.231	0.253	46.305	46.305	86.35	0.002493086	0	0.07125656	3.244e-05	1	30826	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	N	T	D	D	B	0.285714285714286
S302H	302	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.978	-3.5	1.522	13.441	13.441	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S302I	302	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.978	-3.227	1.249	23.717	23.717	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S302K	302	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.978	-3.038	1.06	9.282	9.282	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S302L	302	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.978	-3.004	1.026	31.122	31.122	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S302M	302	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.978	-4.764	2.786	4.13	NA	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S302N	302	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.978	-2.875	0.897	27.821	27.821	86.35	0.002493086	0	0.07125656	4.064e-06	1	246076	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S302P	302	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.978	-2.939	0.961	40.389	40.389	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.725	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S302Q	302	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.978	-2.822	0.844	19.111	19.111	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S302R	302	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.978	-3.962	1.984	6.482	NA	86.35	0.002493086	0	0.07125656	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Sep 21, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00093504207689346	0.000866690123354582	0.000866690123354582	0.00139122286577568	0.000791779931602594	0.000543045589468079	0.000165477839033609	neutral	neutral	low	1.27	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
S302S	302	S	S	synonymous	possibly_wt-like	0.917048555338773	0.266709698934866	2	0.188592236725067	0.547414563593791	1.28668254708376	NA	NA	NA	NA	NA	1.10564079206384	NA	0.728456318613707	0.748158601503499	NA	NA	NA	NA	NA	0.836281889542303	NA	0.660035313464696	p.Ser302=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S302T	302	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.978	-2.792	0.814	20.564	20.564	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.375	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
S302V	302	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.978	-3.048	1.07	15.397	14.764	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S302W	302	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.978	-5.541	3.563	0.613	NA	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.075	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S302X	302	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S302Y	302	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser302Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.978	-4.382	2.404	2.203	NA	86.35	0.002493086	0	0.07125656	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.075	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
I303A	303	I	A	missense	wt-like	0.90753691162495	0.0822107035279494	3	0.0474643718121301	0.814508452324357	1.00056537092554	NA	0.817865316237373	0.979351469669159	NA	NA	NA	NA	0.925393948968317	0.758946855653713	NA	0.68524566988988	0.774377119319029	NA	NA	NA	NA	0.758946855653713	p.Ile303Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.436	-2.694	0.258	21.707	21.707	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.84	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
I303C	303	I	C	missense	possibly_wt-like	1.11709669347934	0.767016451207714	2	0.542362533930615	0.0540856604114544	2.18010772654723	NA	NA	NA	NA	1.65945922740996	0.574734159548728	NA	NA	0.787306254722245	NA	NA	NA	NA	1	0.574612509444489	NA	NA	p.Ile303Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.436	-3.594	1.158	43.413	43.413	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I303D	303	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile303Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.436	-3.911	1.475	8.085	NA	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
I303E	303	I	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile303Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.436	-3.116	0.68	26.536	26.536	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.98	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I303F	303	I	F	missense	possibly_wt-like	0.863085328427977	0.283281012780767	4	0.141640506390384	0.58547503715081	1.14069561970514	1.20802406295803	NA	NA	NA	0.819512071124799	NA	0.905343593547553	0.519461586081532	0.730723656986461	0.881862198547119	NA	NA	NA	0.686247963925199	NA	0.775199350047723	0.555068115134361	p.Ile303Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.436	-4.122	1.686	6.485	NA	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
I303G	303	I	G	missense	wt-like	0.998417587134972	0.104859129873204	8	0.0370733009013318	0.925755252580345	1.0710799216896	1.06158066955125	1.1399428362625	0.95847384419494	0.784782294902888	1.03639605433161	1.0454651198217	1.00685308878292	0.953846789231968	0.789930091742018	0.81218787062206	0.833717986198843	0.764137636497495	0.639864765691261	0.767262335857959	0.806622944092752	0.829871693496905	0.773237239391285	p.Ile303Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.436	-2.805	0.369	45.039	45.039	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
I303H	303	I	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile303His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.436	-3.529	1.093	17.658	17.658	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.735	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
I303K	303	I	K	missense	possibly_low	0.656194350376539	0.442668425310182	5	0.197967338097271	0.268185497590624	1.04420320316245	NA	0.884955879088558	0.531882737856874	0.036527604645676	1.22949649216294	0.598109038128648	NA	NA	0.586133348728213	NA	0.716173290259692	0.55491497798387	0.311716518063924	0.839392653918046	0.586133348728213	NA	NA	p.Ile303Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.436	-2.89	0.454	24.613	24.613	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I303L	303	I	L	missense	wt-like	0.912401776060758	0.271364363721011	8	0.0959417908797498	0.724359321324175	1.10044423079734	1.22057453837738	0.889845776365755	1.05703881304454	1.10907435223956	0.526699345646112	0.484458105050262	0.931408267464082	1.08011501029837	0.785660579222127	0.887833420052173	0.718427450609665	0.812479068169732	0.782083547237304	0.576871334550244	0.530117907622732	0.78923761120695	0.836655208078394	p.Ile303Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.436	-2.413	-0.023	33.545	33.545	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
I303M	303	I	M	missense	wt-like	1.2821728775426	0.163799613309511	2	0.115823817326889	1.05516236702995	1.50918338805525	NA	1.39799669486949	NA	NA	NA	NA	NA	1.16634906021571	0.916321282088843	NA	0.952676472084035	NA	NA	NA	NA	NA	0.879966092093652	p.Ile303Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.436	-3.224	0.788	13.424	13.424	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
I303N	303	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile303Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.436	-2.998	0.562	28.45	28.45	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
I303P	303	I	P	missense	wt-like	1.0303562363211	0.218895723854694	8	0.0773913253551961	0.878672025909095	1.18204044673311	1.23291945024922	0.789179899039305	0.971653194393534	0.69654993778918	1.33927574652777	1.18090032784484	1.05387117354291	0.978500161182042	0.820407335422878	0.893706839248184	0.672022175324491	0.770601481254368	0.601170329494757	0.880399358111289	0.873375259389594	0.855195323294896	0.785619347550861	p.Ile303Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.436	-3.005	0.569	41.371	41.371	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.39	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
I303Q	303	I	Q	missense	wt-like	1.0171505165225	0.261894678166977	6	0.106918054643252	0.807594980124643	1.22670605292036	NA	0.966276510602971	1.01506538930848	1.1639201364411	1.31680195655229	0.545089615351565	1.09574949087861	NA	0.799014674786666	NA	0.753660732797472	0.791893099145761	0.806136250427571	0.872004547425447	0.560001523202699	0.877750708317177	NA	p.Ile303Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.436	-3.318	0.882	18.951	18.951	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.735	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I303R	303	I	R	missense	wt-like	1.09522974161105	0.155931946993025	8	0.0551302685611945	0.98717640077309	1.20328308244901	0.936900701732771	0.941261589431299	1.00329540161254	1.10443066437814	1.36166766236693	1.24850630185372	1.17803251593075	0.987743095582271	0.788191036546336	0.752868069561858	0.742129275127423	0.786120479698635	0.780047050768798	0.888763585710107	0.906696397658309	0.92206780195711	0.790261593394036	p.Ile303Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.436	-3.016	0.58	28.087	28.087	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.735	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I303S	303	I	S	missense	wt-like	1.06350238747879	0.205632627661968	6	0.0839491687065904	0.8989650402818	1.22803973467579	NA	0.970902749238932	1.07720922105121	0.858052474413544	1.41393565922164	1.16361902717569	NA	0.897295193771733	0.789082522696999	NA	0.755793350951094	0.822371694442904	0.671997515840141	0.908287659709296	0.864857778242378	NA	0.744834310453076	p.Ile303Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.436	-3.627	1.191	6.331	NA	89.83	0.002495571	0	0.071327564	8.128e-06	2	246056	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Nov 25, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
I303T	303	I	T	missense	wt-like	0.983313906781942	0.119458342637192	5	0.0534233949232446	0.878605976800523	1.08802183676336	NA	0.846086276854901	1.02973050733065	1.15609074357821	NA	NA	0.904355832537178	0.980306173608764	0.786526413783037	NA	0.698255057788239	0.799085642390167	0.802702658120841	NA	NA	0.774667348493782	0.786526413783037	p.Ile303Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.436	-3.068	0.632	11.838	11.838	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
I303V	303	I	V	missense	wt-like	1.07577758457932	0.19044054683403	8	0.0673309010396084	0.94381144349506	1.20774372566359	0.696234595644839	1.0605339487671	1.04869089088709	1.21669876489296	1.14099637559646	1.29489560461015	1.20959091372185	0.938579582514149	0.807359660911936	0.63836478739985	0.79711182548002	0.80838480919223	0.829282399277904	0.806334512631641	0.929560418094327	0.939064946497533	0.765569314481968	p.Ile303Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.436	-2.467	0.031	23.917	23.917	89.83	0.002495571	0	0.071327564	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Mar 5, 2014)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
I303W	303	I	W	missense	wt-like	0.952571377229175	0.25764590292957	7	0.0973809979237616	0.761708128520032	1.14343462593832	0.447887625040214	1.23327907910569	1.1072692370431	1.10704676690988	0.969615863682472	0.82570525516984	NA	0.977195813653029	0.781194346566043	0.520207130256258	0.876744423341754	0.837114703303947	0.781194346566043	0.742317408514795	0.698309308451377	NA	0.784964241538806	p.Ile303Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.436	-3.629	1.193	42.508	42.508	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I303X	303	I	X	nonsense	low	0.0286361783868636	0.034854773385826	5	0.0155875285262115	-0.00191481613250163	0.0591871729062288	0.0102747296042783	-0.0244480751471333	0.0524097432668286	0.051280314753441	NA	NA	NA	0.0536641794569034	0.318186341818658	0.312001190257685	0.29695337222452	0.319756267164149	0.318186341818658	NA	NA	NA	0.321122272717515	p.Ile303Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I303Y	303	I	Y	missense	wt-like	1.0354695405311	0.0887883513444852	5	0.0397073578432808	0.957644549237026	1.11329453182517	NA	1.1382871902	1.05019561437396	0.923780919009655	0.968301543878219	NA	NA	1.09678243519367	0.809122804531502	NA	0.832954761227826	0.809122804531502	0.700822826518875	0.741826460350316	NA	NA	0.845026389846674	p.Ile303Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.436	-3.062	0.626	15.673	15.673	89.83	0.002495571	0	0.071327564	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
C304A	304	C	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	195	2.5	1.8	0.7	148	121	27	5.5	8.1	-2.6	121	89	32	5.07	6	0.93	-2.624	-2.654	0.03	25.516	25.516	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304D	304	C	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	2.5	-3.5	6	148	187	-39	5.5	13	-7.5	121	133	-12	5.07	5.05	-0.02	-2.624	-3.864	1.24	8.04	NA	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C304E	304	C	E	missense	wt-like	1.33134399321327	0.125475278373253	3	0.0724431857454406	1.18935795822686	1.47333002819968	NA	NA	NA	NA	1.46821761711183	1.30405634642563	1.22175801610234	NA	0.93407549755517	NA	NA	NA	NA	0.928564024338586	0.93407549755517	0.945618067450258	NA	p.Cys304Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	2.5	-3.5	6	148	214	-66	5.5	12.3	-6.8	121	147	-26	5.07	3.22	-1.85	-2.624	-2.909	0.285	26.389	26.389	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.175	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C304F	304	C	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	205	2.5	2.8	-0.3	148	228	-80	5.5	5.2	0.3	121	165	-44	5.07	3.32	-1.75	-2.624	-3.308	0.684	35.007	35.007	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
C304G	304	C	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	159	2.5	-9.4	11.9	148	97	51	5.5	9	-3.5	121	75	46	5.07	3.29	-1.78	-2.624	-2.613	-0.011	46.052	46.052	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	null	N	D	D	D	D	B	0.428571428571429
C304H	304	C	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	2.5	-3.2	5.7	148	216	-68	5.5	10.4	-4.9	121	155	-34	5.07	7.59	2.52	-2.624	-4.805	2.181	4.268	NA	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
C304I	304	C	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	2.5	4.5	-2	148	191	-43	5.5	5.2	0.3	121	131	-10	5.07	6.02	0.95	-2.624	-2.914	0.29	14.504	12.263	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304K	304	C	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	2.5	-3.9	6.4	148	230	-82	5.5	11.3	-5.8	121	146	-25	5.07	9.74	4.67	-2.624	-3.735	1.111	10.849	NA	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C304L	304	C	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	2.5	3.8	-1.3	148	191	-43	5.5	4.9	0.6	121	131	-10	5.07	9.71	4.64	-2.624	-2.56	-0.064	31.215	31.215	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304M	304	C	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	196	2.5	1.9	0.6	148	203	-55	5.5	5.7	-0.2	121	149	-28	5.07	5.74	0.67	-2.624	-3.234	0.61	13.545	13.545	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304N	304	C	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	2.5	-3.5	6	148	187	-39	5.5	11.6	-6.1	121	132	-11	5.07	5.47	0.4	-2.624	-3.227	0.603	28.136	28.136	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C304P	304	C	P	missense	possibly_wt-like	0.879605525300507	0.49835623951269	2	0.352391076406051	0.188931707071345	1.57027934352967	NA	NA	NA	NA	0.527214448894456	1.23199660170656	NA	NA	0.737811481217292	NA	NA	NA	NA	0.57706374509863	0.898559217335954	NA	NA	p.Cys304Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	2.5	-1.6	4.1	148	154	-6	5.5	8	-2.5	121	115	6	5.07	6.3	1.23	-2.624	-3.26	0.636	20.501	20.501	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
C304Q	304	C	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	2.5	-3.5	6	148	214	-66	5.5	10.5	-5	121	146	-25	5.07	6.24	1.17	-2.624	-3.075	0.451	19.111	19.111	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.77	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304R	304	C	R	missense	possibly_wt-like	0.958330195733241	0.450137633162985	6	0.183767919212238	0.598151692563388	1.31850869890309	1.02595359427626	1.16997632772407	1.25123820551633	1.33492499864933	0.862129962056147	0.105758086177307	NA	NA	0.821400132541394	0.795237344770576	0.847562920312212	0.907724638391443	0.881130696302806	0.702167358321464	0.34346701062401	NA	NA	p.Cys304Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	2.5	-4.5	7	148	265	-117	5.5	10.5	-5	121	174	-53	5.07	6.34	1.27	-2.624	-3.035	0.411	30.904	30.904	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.175	Neutral	TOLERATED	effect	DAMAGING	null	N	D	D	D	D	B	0.428571428571429
C304S	304	C	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	2.5	-0.8	3.3	148	143	5	5.5	9.2	-3.7	121	105	16	5.07	5.68	0.61	-2.624	-2.829	0.205	19.755	19.755	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
C304T	304	C	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	2.5	-0.7	3.2	148	163	-15	5.5	8.6	-3.1	121	119	2	5.07	5.6	0.53	-2.624	-2.676	0.052	21.479	21.479	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304V	304	C	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	2.5	4.2	-1.7	148	165	-17	5.5	5.9	-0.4	121	117	4	5.07	5.61	0.54	-2.624	-2.626	0.002	23.783	23.783	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
C304W	304	C	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Trp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	215	2.5	-0.9	3.4	148	264	-116	5.5	5.4	0.0999999999999996	121	204	-83	5.07	5.89	0.82	-2.624	-5.351	2.727	2.49	NA	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.87	Neutral	TOLERATED	effect	DAMAGING	pathogenic	N	D	T	D	D	D	0.5
C304X	304	C	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	2.5	NA	NA	148	NA	NA	5.5	NA	NA	121	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C304Y	304	C	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Cys304Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	194	2.5	-1.3	3.8	148	255	-107	5.5	6.2	-0.7	121	181	-60	5.07	5.66	0.59	-2.624	-3.075	0.451	28.747	28.747	86.35	0.002303513	0	0.065838244	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.175	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
S305A	305	S	A	missense	wt-like	1.16929026467449	0.114486469235978	5	0.0511999055431171	1.06894029379813	1.26964023555085	0.977220209455476	1.27724630179698	1.16825556421138	1.22319978491993	NA	NA	NA	1.20052946298867	0.867025597632386	0.772051144588299	0.897012573053471	0.867025597632386	0.832133431630145	NA	NA	NA	0.897133132972672	p.Ser305Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.017	-3.199	1.182	7.007	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S305C	305	S	C	missense	wt-like	0.942546335343301	0.183844094181391	7	0.0694865361731281	0.80635522703353	1.07873744365307	NA	0.998035431031428	0.770927616812894	0.649744351482991	1.07014276829942	1.18425332325076	1.02958603903189	0.895134817493726	0.768301060626367	NA	0.768301060626367	0.672155127476371	0.580643667483101	0.779868010082826	0.875027859254811	0.842115510301856	0.743749265665133	p.Ser305Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.017	-5.141	3.124	1.634	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	low	1.52	Neutral	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.714285714285714
S305D	305	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.017	-2.701	0.684	35.636	35.636	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S305E	305	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.017	-2.376	0.359	13.563	13.563	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S305F	305	S	F	missense	wt-like	0.949778579132932	0.205684335627386	8	0.0727203942529872	0.807249225455523	1.09230793281034	1.11761720654159	0.89522742608277	0.946344975235603	0.774165903351085	1.36175942489159	0.753617482923171	0.789078537312644	0.96041767672501	0.739548651704735	0.838848739120267	0.720908300558418	0.758189002851052	0.635208930814166	0.888797862484226	0.662779214229242	0.712579758935828	0.776537454867205	p.Ser305Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.017	-4.296	2.279	10.721	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S305G	305	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.017	-2.613	0.596	45.546	45.546	89.83	0.002349314	0	0.067147298	4.064e-06	1	246056	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Mar 24, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.5
S305H	305	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.017	-4.623	2.606	3.847	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S305I	305	S	I	missense	wt-like	1.12853976109162	0.100039447249925	2	0.0707385715365758	0.989894708562122	1.26718481362112	NA	1.05780118955504	1.1992783326282	NA	NA	NA	NA	NA	0.839046430132625	NA	0.795852069474396	0.882240790790854	NA	NA	NA	NA	NA	p.Ser305Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.017	-3.978	1.961	14.382	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.215	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.642857142857143
S305K	305	S	K	missense	wt-like	1.15079891468064	0.137353273510746	4	0.0686766367553731	1.01619518006076	1.28540264930051	NA	1.30999985143212	1.09848081929199	0.99057811168266	NA	NA	NA	1.20413687631577	0.865874675742384	NA	0.912111408207475	0.832804402177889	0.730116838313893	NA	NA	NA	0.89894494930688	p.Ser305Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.017	-2.532	0.515	15.194	15.194	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S305L	305	S	L	missense	wt-like	0.886068709789049	0.201182391387024	7	0.0760397965393325	0.737033447180204	1.03510397239789	0.489148260664667	0.925437039299968	0.928871058161964	1.04451727338772	0.761142172877361	NA	0.997861849833464	1.0555033142982	0.749618877195652	0.539837971839594	0.734834423837079	0.749618877195652	0.753771940811037	0.66444459893542	NA	0.82502907160485	0.824294031583676	p.Ser305Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.017	-3.548	1.531	16.397	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S305M	305	S	M	missense	possibly_wt-like	0.838758726616516	0.125062620575771	3	0.0722049376549812	0.697239649306793	0.980277803926239	NA	NA	NA	NA	0.894762742379383	0.695481735633355	0.92603170183681	NA	0.714356936192623	NA	NA	NA	NA	0.714356936192623	0.634125692078309	0.786341828483672	NA	p.Ser305Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.017	-3.465	1.448	13.464	13.464	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S305N	305	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.017	-2.775	0.758	27.821	27.821	89.83	0.002349314	0	0.067147298	0	NA	NA	PTEN hamartoma tumor syndrome|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Nov 25, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	1	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.5
S305P	305	S	P	missense	wt-like	1.17323613753245	0.182914777739665	7	0.0691352875739726	1.03773346382664	1.30873881123826	NA	1.21919651524144	1.16232618686832	1.51039551401137	1.18760289412922	0.929691108323804	1.01485993045273	1.18858081370026	0.864117519914371	NA	0.870252598403671	0.864117519914371	0.958083561251141	0.823743810317324	0.749561095615602	0.834184125518169	0.891131947084206	p.Ser305Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.017	-3.096	1.079	43.458	43.458	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.87	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S305Q	305	S	Q	missense	wt-like	1.06423492267599	0.0763424274936957	2	0.0539822481730345	0.958431660452341	1.17003818489964	NA	1.01025267450296	NA	NA	NA	NA	NA	1.11821717084903	0.814862474218536	NA	0.773933004255922	NA	NA	NA	NA	NA	0.85579194418115	p.Ser305Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.017	-3.121	1.104	18.792	18.792	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S305R	305	S	R	missense	possibly_wt-like	0.906563209283979	0.327203645702121	7	0.1236713535145	0.664171810476238	1.14895460809172	NA	1.15159482693055	0.968707159791019	1.25189672628351	1.10274581487648	0.276665962001323	0.800489483731357	0.793842491373612	0.769156591329441	NA	0.839089357798953	0.769156591329441	0.844718519493058	0.792046481275032	0.427702835120762	0.718725619283548	0.692875391685777	p.Ser305Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.017	-2.855	0.838	30.221	30.221	89.83	0.002349314	0	0.067147298	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 16, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.5
S305T	305	S	T	missense	wt-like	1.09229107917664	0.097872784086365	7	0.0369924352591488	1.01978723836828	1.16479491998501	NA	1.07456201697976	0.979275206590822	1.09410020276439	0.967383617784067	1.23170767593995	1.11209641177349	1.18691242240403	0.803578528839856	NA	0.803578528839856	0.774339715904474	0.775516610906711	0.74148358023119	0.898416813716159	0.886555051905225	0.890294000797415	p.Ser305Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.017	-2.54	0.523	21.479	21.479	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.12	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.357142857142857
S305V	305	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.017	-3.015	0.998	23.583	23.583	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.215	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S305W	305	S	W	missense	possibly_wt-like	0.805960458458384	0.14479118982304	6	0.0591107557194849	0.690105506149248	0.921815410767519	NA	0.638312661962433	0.708487609404577	1.0600521650835	0.843742263192984	0.771753936498716	0.813414114608088	NA	0.68350851706148	NA	0.602474918061118	0.64153127209476	0.7605847915067	0.695298857233177	0.671718176889782	0.725686740079273	NA	p.Ser305Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.017	-5.433	3.416	2.244	NA	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.215	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S305X	305	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S305Y	305	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser305Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.017	-3.28	1.263	25.912	25.912	89.83	0.002349314	0	0.067147298	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.215	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I306A	306	I	A	missense	possibly_wt-like	0.874775183969981	0.206158969403847	4	0.103079484701924	0.672743106409263	1.0768072615307	0.605654343929451	0.824994171928576	1.00463564987311	1.06381657014879	NA	NA	NA	NA	0.725383814768917	0.595268830561278	0.688531952388027	0.786777807758173	0.762235677149806	NA	NA	NA	NA	p.Ile306Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-2.323	-2.565	0.242	26.163	26.163	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306C	306	I	C	missense	possibly_wt-like	0.77518415284553	0.531531133586482	4	0.265765566793241	0.254293213599904	1.29607509209116	NA	0.992793717615305	1.23801894928716	NA	NA	0.0139490258316816	NA	0.855974918647973	0.744983000758071	NA	0.765884718957259	0.901241221623611	NA	NA	0.298216832086603	NA	0.724081282558883	p.Ile306Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-2.323	-3.141	0.818	43.173	43.173	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306D	306	I	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-2.323	-2.614	0.291	34.848	34.848	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306E	306	I	E	missense	wt-like	1.04841204431775	0.201710327430863	8	0.071315370180861	0.908636487219124	1.18818760141638	1.30098532179988	1.14364698841422	1.10812968907076	0.823200053732121	1.27168864671803	0.819899273819514	1.10113715571352	0.818609225273981	0.836481126060588	0.926090982667702	0.83542553800154	0.837536714119636	0.656712933035523	0.855153019673184	0.695447698805248	0.880652469000355	0.705314435664622	p.Ile306Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-2.323	-2.786	0.463	26.242	26.242	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306F	306	I	F	missense	wt-like	0.936169355606857	0.224252673286336	8	0.0792852929899898	0.780773036842771	1.09156567437094	1.11163426654927	0.705510874514156	0.952227781063646	1.01639934049825	0.745522894548292	1.35122561277485	0.896890860734999	0.709943214171394	0.751257508730836	0.836002196758177	0.63345216313118	0.761074239454853	0.741440778006818	0.658610207639379	0.957323940745256	0.770646764003032	0.650737142730143	p.Ile306Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-2.323	-4.196	1.873	4.864	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306G	306	I	G	missense	possibly_wt-like	0.810905262007576	0.357401180767306	8	0.126360399262321	0.563243430381326	1.05856709363383	1.19661510687827	1.04527932604833	1.12533325988554	1.09584007460451	0.236706588265343	0.660177679904702	0.430050563419891	0.697239497054029	0.710318179937701	0.876434085139671	0.790079701135241	0.845974247786691	0.776279634383697	0.468548069932544	0.616725287164	0.51920966433516	0.644356725491705	p.Ile306Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-2.323	-2.691	0.368	45.039	45.039	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306H	306	I	H	missense	possibly_wt-like	0.919513032061471	0.478898421208097	6	0.195509461764049	0.536321528367125	1.30270453575582	0.897082021489036	1.34116274729347	1.05072319182506	1.22558450891098	NA	-0.00255485915783403	NA	1.00508058200811	0.804175434227775	0.733923276489911	0.926476978741761	0.809381556191467	0.833179256011773	NA	0.290082517896642	NA	0.798969312264083	p.Ile306His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-2.323	-4.903	2.58	2.75	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
I306I	306	I	I	synonymous	wt-like	1.0853479243714	0.110936458926668	8	0.0392219611939348	1.00847429302826	1.16222155571454	1.01806643134873	1.16642958435373	0.835559806874063	1.15787841212493	1.13073513888576	1.14552292255315	1.11850955047836	1.11008154835245	0.824707287112892	0.791484817849239	0.845927931308614	0.703854144237961	0.80348664291717	0.802501552562026	0.855938702478842	0.890009126039343	0.851705843590041	p.Ile306=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	4.5	4.5	0	191	191	0	5.2	5.2	0	131	131	0	6.02	6.02	0	NA	NA	NA	NA	NA	NA	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
I306K	306	I	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-2.323	-3.751	1.428	8.12	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
I306L	306	I	L	missense	wt-like	0.912944738926336	0.237511883936391	8	0.0839731318719072	0.748360424788365	1.07752905306431	1.11146910260962	0.90705105230903	1.04972893627538	1.03522003245465	0.379291976357036	0.960126553308692	0.799646191941725	1.06102406615455	0.757128258363509	0.835923615633929	0.726358793262309	0.808893921108936	0.74969462147087	0.521809106050745	0.764561895256149	0.718271427897375	0.827066818476521	p.Ile306Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-2.323	-2.315	-0.008	33.358	33.358	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.37	Neutral	TOLERATED	neutral	DAMAGING	null	N	N	T	T	D	D	0.214285714285714
I306M	306	I	M	missense	possibly_low	0.399181664464231	0.503831763622168	3	0.290887404353542	-0.170947171625052	0.969310500553513	NA	NA	0.578693183550173	NA	-0.169821585339479	NA	NA	0.788673395181998	0.577873276337137	NA	NA	0.577873276337137	NA	0.316694419097657	NA	NA	0.690279223167271	p.Ile306Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-2.323	-3.413	1.09	13.464	13.464	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	N	N	T	D	D	B	0.285714285714286
I306N	306	I	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-2.323	-3.94	1.617	6.094	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306P	306	I	P	missense	wt-like	1.02620305652246	0.156383893406496	7	0.0591075558585175	0.910354375825579	1.14205173721935	NA	0.8010470426818	1.15266977676545	1.15445573187399	1.22302055759233	0.924207413346294	0.906037864761662	1.0219830086357	0.801985621218066	NA	0.677492728824888	0.859381509802103	0.801985621218066	0.83697364738673	0.746858332120987	0.775573279936514	0.807458523195795	p.Ile306Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-2.323	-3.144	0.821	41.371	41.371	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306Q	306	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-2.323	-3.241	0.918	19.217	19.217	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.265	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306R	306	I	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-2.323	-4.09	1.767	6.518	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
I306S	306	I	S	missense	possibly_low	0.542853758002224	0.320450932468382	7	0.121119067815727	0.305464747242334	0.780242768762114	0.371096294236344	0.05256182141445	0.299668834060616	0.536828213759735	0.842917633178415	NA	0.776855049016509	0.920048460349495	0.531124121257475	0.483671618207798	0.332453638496814	0.441025097078622	0.531124121257475	0.694990826728945	NA	0.705996268901483	0.756262094381378	p.Ile306Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-2.323	-2.737	0.414	19.755	19.755	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
I306T	306	I	T	missense	possibly_wt-like	0.713470445301238	0.575449461368155	5	0.257348822646967	0.209076021449397	1.21786486915308	NA	1.12864450373693	0.994118793384576	0.859253960499277	-0.298108377977899	NA	NA	0.883443346863303	0.737877247257932	NA	0.828509645050512	0.78161978959735	0.672524429414777	0.268774449263096	NA	NA	0.737877247257932	p.Ile306Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-2.323	-2.568	0.245	22.333	22.333	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.51	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
I306V	306	I	V	missense	possibly_wt-like	0.960866881196118	0.356613508655052	5	0.159482409409481	0.648287102585863	1.27344665980637	NA	1.17835955111472	1.06209601816998	1.14299561992791	0.327985162117111	NA	NA	1.09289805465087	0.814959386876036	NA	0.851427445209352	0.814959386876036	0.796959771461711	0.502644070117433	NA	NA	0.843075467266539	p.Ile306Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-2.323	-2.481	0.158	23.649	23.649	86.35	0.003012772	0	0.086110051	0	NA	NA	PTEN hamartoma tumor syndrome|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 14, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	N	N	T	T	D	B	0.142857142857143
I306W	306	I	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile306Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-2.323	-5.475	3.152	0.661	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I306X	306	I	X	nonsense	low	0.214313653252059	0.163400623183789	5	0.0730749802009562	0.0710893238872073	0.357537982616911	0.241790615887836	0.072770367773847	0.107070616824642	0.166823487293839	NA	0.483113178480131	NA	NA	0.368857978212145	0.422151012694368	0.341769438267573	0.346564827193949	0.368857978212145	NA	0.529455030046281	NA	NA	p.Ile306Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I306Y	306	I	Y	missense	possibly_wt-like	0.854712022912472	0.199104003405525	5	0.0890420172414205	0.680192876008493	1.02923116981645	NA	0.938357989970313	0.915655955286967	0.500104807774277	0.965147121307179	NA	0.954294240223622	NA	0.740790764642207	NA	0.740790764642207	0.743137497450602	0.515019014964198	0.740648164195732	NA	0.801563844925057	NA	p.Ile306Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-2.323	-4.34	2.017	1.985	NA	86.35	0.003012772	0	0.086110051	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E307A	307	E	A	missense	possibly_wt-like	0.748661255333741	0.333046390598753	4	0.166523195299377	0.422281789956434	1.07504072071105	NA	0.89926212895501	0.897068832742097	0.250336706578369	NA	0.947977353059489	NA	NA	0.728394814055501	NA	0.72276823068025	0.734021397430752	0.405482829240497	NA	0.758573886248176	NA	NA	p.Glu307Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.933	-3.248	1.315	7.046	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.76	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
E307C	307	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.933	-5.22	3.287	1.251	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E307D	307	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.933	-2.145	0.212	32.289	32.289	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.185	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
E307F	307	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.933	-4.423	2.49	4.32	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E307G	307	E	G	missense	wt-like	0.919824773931935	0.243989948963426	8	0.0862634737266989	0.750751472246288	1.08889807561758	0.419284122962403	0.872314854259477	0.813258124720332	0.963906468277377	1.26413592841288	0.96405119287393	0.97851604725335	1.08313145269573	0.742458095453939	0.506598255610484	0.710345990556358	0.692916229311456	0.718419947991994	0.85233179368485	0.766496242915884	0.814609550155081	0.838170210411415	p.Glu307Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.933	-2.58	0.647	45.799	45.799	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.98	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E307H	307	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.933	-4.64	2.707	2.705	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E307I	307	E	I	missense	wt-like	1.06110859228902	0.139819248689687	2	0.0988671388888861	0.867332560812288	1.25488462376576	NA	NA	NA	NA	NA	1.15997573117791	NA	0.962241453400138	0.820257770151086	NA	NA	NA	NA	NA	0.863062097143545	NA	0.777453443158628	p.Glu307Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.933	-3.978	2.045	9.081	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E307K	307	E	K	missense	wt-like	1.02285256487864	0.266162896127664	6	0.108660547329029	0.809881805573329	1.23582332418394	NA	1.10829005023828	1.08732102752275	0.494020440912043	1.22404823239102	NA	1.17011521208185	1.05332042612588	0.825264367533037	NA	0.819126584544108	0.827331054825519	0.512350706499499	0.837357522798533	NA	0.917803594414607	0.823197680240556	p.Glu307Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.933	-2.851	0.918	24.613	24.613	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E307L	307	E	L	missense	possibly_low	0.514737335275628	0.34712733293147	7	0.131201799458542	0.25758653363004	0.771888136921217	NA	0.149016368199219	0.425399094789907	-0.0466560121775583	0.7402863281219	0.79501378401168	0.713964290672854	0.826137493311399	0.656654151992274	NA	0.376917561277109	0.502689813043298	0.275236214702959	0.656654151992274	0.683182320502103	0.672123721983863	0.709095493658731	p.Glu307Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.933	-2.946	1.013	29.631	29.631	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E307M	307	E	M	missense	wt-like	0.977155625841517	0.0718444204505956	7	0.0271546385142627	0.923933512340358	1.03037773934268	NA	1.01942446717047	0.900628632591906	0.912188503160033	1.04813881706003	0.924649854938872	0.954085150445511	1.08097395552381	0.771648701937795	NA	0.778161046318418	0.73576731003251	0.695738954681716	0.771648701937795	0.747076399498882	0.801451230552046	0.837086611648907	p.Glu307Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.933	-4.765	2.832	3.933	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E307N	307	E	N	missense	possibly_wt-like	0.948313122939573	0.448389413796131	5	0.200525841927886	0.555289694791344	1.3413365510878	NA	0.530544279983634	0.716232567565945	0.732985791239738	1.65945922740996	NA	1.10234374849859	NA	0.645329805895682	NA	0.552795507663231	0.645329805895682	0.617149329180675	1	NA	0.881302331902299	NA	p.Glu307Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.933	-2.961	1.028	25.856	25.856	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.735	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E307P	307	E	P	missense	possibly_low	0.659247461744053	0.220098827775762	2	0.155633373651451	0.354211654594743	0.964283268893362	0.503614088092601	0.814880835395504	NA	NA	NA	NA	NA	NA	0.615295173652478	0.54672047285568	0.683869874449275	NA	NA	NA	NA	NA	NA	p.Glu307Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.933	-2.573	0.64	43.458	43.458	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.39	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E307Q	307	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.933	-3.06	1.127	18.898	18.898	89.83	0.003220994	0	0.092061386	4.064e-06	1	246040	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jun 11, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
E307R	307	E	R	missense	wt-like	0.912119428072822	0.244320576468147	8	0.0863803682020165	0.74281701742556	1.08142183872008	0.983985725706061	1.04660211959074	0.905536538554107	0.886127307101034	1.12253373601704	0.358714311036015	1.11720595822834	0.876249728349247	0.756722211477435	0.77527001835829	0.790689486696258	0.738174404596579	0.684309776984356	0.799438018351002	0.468142225618197	0.88930701986646	0.734264266336695	p.Glu307Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.933	-2.819	0.886	30.733	30.733	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.39	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E307S	307	E	S	missense	possibly_wt-like	0.830417662340985	0.588711335256342	4	0.294355667628171	0.253491155144527	1.40734416953744	NA	1.10515419096267	1.15795177856464	NA	-0.0519316424097087	NA	NA	1.11049632224634	0.834797584582754	NA	0.81768100619318	0.86197208059057	NA	0.360730772277951	NA	NA	0.851914162972327	p.Glu307Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.933	-2.644	0.711	10.86	10.86	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E307T	307	E	T	missense	wt-like	1.38480797847468	0.245316264779013	3	0.141633411506757	1.1072115929139	1.66240436403546	NA	NA	NA	NA	1.65945922740996	NA	1.18743996598953	1.30752474202455	0.950871303972939	NA	NA	NA	NA	1	NA	0.927134592402695	0.950871303972939	p.Glu307Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.933	-2.907	0.974	12.265	12.265	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E307V	307	E	V	missense	wt-like	0.999552461527276	0.0800420837348027	3	0.0462123185907869	0.908977981447242	1.09012694160731	NA	1.02253303366789	0.910533760364974	1.06559059054896	NA	NA	NA	NA	0.763013676530435	NA	0.779594043157926	0.740625304338552	0.763013676530435	NA	NA	NA	NA	p.Glu307Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.933	-2.989	1.056	11.825	11.825	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
E307W	307	E	W	missense	wt-like	1.05516352135655	0.247073265920506	3	0.142647816588764	0.775578938369295	1.3347481043438	NA	NA	NA	NA	1.13017141950435	NA	0.779278448566418	1.25604069599887	0.802290982048907	NA	NA	NA	NA	0.802290982048907	NA	0.707301495887392	0.925013541891814	p.Glu307Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.933	-5.543	3.61	0.586	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.08	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E307X	307	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E307Y	307	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu307Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.933	-4.407	2.474	1.763	NA	89.83	0.003220994	0	0.092061386	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.08	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R308A	308	R	A	missense	wt-like	0.944249123997385	0.259958309993336	7	0.0982550056410006	0.751672851640244	1.13682539635453	0.942962132204168	0.893450118530003	1.12496463293933	1.24063709084676	1.17004612834411	0.519796974803434	NA	0.717886790313904	0.755751955850849	0.755751955850849	0.720088991687894	0.84579345379324	0.839780589018846	0.81718569416591	0.547535471418955	NA	0.654726788413077	p.Arg308Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-2.244	-2.617	0.373	25.444	25.444	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308C	308	R	C	missense	wt-like	1.24439848373776	0.0283158992917293	3	0.0163481920784263	1.2123566160517	1.27644035142382	NA	1.21774345058239	1.27412484351593	1.24132715711496	NA	NA	NA	NA	0.869582760050289	NA	0.869582760050289	0.918949446352909	0.840083218644302	NA	NA	NA	NA	p.Arg308Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-2.244	-3.213	0.969	43.173	43.173	39.95	0.003092371	0	0.088385109	0	NA	NA	not specified	Uncertain significance(Last reviewed: Sep 22, 2016)	criteria provided, single submitter	0	0	1	0	0	3	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.1	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
R308D	308	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-2.244	-2.811	0.567	31.305	31.305	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308E	308	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-2.244	-2.947	0.703	26.536	26.536	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308F	308	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-2.244	-4.406	2.162	2.151	NA	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308G	308	R	G	missense	possibly_wt-like	0.79336733315155	0.514261574269124	7	0.194372604907525	0.412404027951568	1.17433063835153	0.513636814697105	1.28895496585095	1.17631847975229	1.02984182519146	-0.201704703051501	0.703811236915801	NA	1.04271271270474	0.747336000386668	0.551489050829053	0.9024100701307	0.870980074413024	0.747336000386668	0.304784868569738	0.638231075781609	NA	0.81786997678594	p.Arg308Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-2.244	-2.515	0.271	44.786	44.786	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
R308H	308	R	H	missense	possibly_low	0.571405550776024	0.418741322412142	3	0.24176041521547	0.097563844066254	1.04524725748579	NA	0.686906777395537	NA	NA	0.107036080202478	0.920273794730057	NA	NA	0.624875987458247	NA	0.624875987458247	NA	NA	0.420111230044291	0.744919558932234	NA	NA	p.Arg308His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-2.244	-3.147	0.903	22.753	22.753	39.95	0.003092371	0	0.088385109	8.129e-06	2	246028	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Sep 12, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
R308I	308	R	I	missense	wt-like	1.10012039715652	0.150990162004857	8	0.053383083723045	0.995491475675669	1.20474931863738	1.23942706283766	1.13215216465354	1.07949639141152	1.27661460615411	1.11705015652934	0.797042654473934	1.16500828592972	0.994171855262354	0.826810030239289	0.896803008511601	0.830126617700681	0.823493442777897	0.855558583805668	0.797389693981585	0.684182295344463	0.915053037731099	0.793490425452057	p.Arg308Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-2.244	-4.011	1.767	7.497	NA	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308K	308	R	K	missense	wt-like	1.16477427234123	0.0983471225631338	4	0.0491735612815669	1.06839586323778	1.26115268144467	NA	NA	NA	NA	1.24202100149566	1.20680251760957	1.18930857144263	1.02096499881705	0.865106386630804	NA	NA	NA	NA	0.844071031926204	0.886141741335403	0.928141010953647	0.806947229742402	p.Arg308Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-2.244	-2.586	0.342	24.613	24.613	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
R308L	308	R	L	missense	wt-like	0.952095079563669	0.127394370025392	8	0.0450407114649715	0.863816907254265	1.04037325187307	0.885354386002584	0.827426584697088	0.9505849107556	0.926815606580028	0.943604870250455	1.21785854769391	1.03624412837086	0.828871602158828	0.73047243071883	0.728343542903712	0.689653253737877	0.760268489666976	0.702153693429942	0.732601318533948	0.891590956623609	0.845701513229083	0.710468694514885	p.Arg308Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-2.244	-3.56	1.316	8.908	NA	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.1	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
R308M	308	R	M	missense	possibly_wt-like	0.743111737227416	0.702483294144543	5	0.314160079753035	0.127369295531236	1.3588541789236	0.422768368356882	1.10907735541796	1.28250573455822	1.24913743214409	-0.347930204340072	NA	NA	NA	0.819489518981943	0.508255977755122	0.819489518981943	0.923059875001161	0.843508426795574	0.250164112475682	NA	NA	NA	p.Arg308Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-2.244	-3.52	1.276	7.315	7.315	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308N	308	R	N	missense	wt-like	0.998467095479643	0.179369120846198	7	0.0677951552347616	0.865591032893208	1.13134315806608	NA	1.07795973586254	1.12446477023688	1.16140824142827	0.890429823481454	1.08230774704022	1.0084832228087	0.644216127499433	0.805144820062708	NA	0.805144820062708	0.845548294899996	0.805034654998347	0.712738427080235	0.824781668876004	0.830749672912713	0.61772584115914	p.Arg308Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-2.244	-3.073	0.829	15.797	15.797	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308P	308	R	P	missense	wt-like	1.06100351027962	0.190127482471656	7	0.0718614337169705	0.920157688316942	1.20184933224229	NA	1.17271927880697	0.988726857043423	1.11327027158388	1.24730843704556	1.16780111729197	1.06392032894853	0.673278281236981	0.846046089115198	NA	0.848827374598772	0.778975301142079	0.783923674132535	0.846046089115198	0.86691901624774	0.860607732000467	0.632322251405059	p.Arg308Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-2.244	-3.165	0.921	40.389	40.389	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.445	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
R308Q	308	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-2.244	-2.958	0.714	10.882	10.882	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308R	308	R	R	synonymous	wt-like	0.906901034105113	0.270569818525504	8	0.0956608767318987	0.719409160981066	1.09439290722916	0.974661438972698	0.895633958242256	1.01230759792266	0.510465921494096	1.05664132644274	1.20783537450125	1.11751978828995	0.480142866975259	0.772829226248689	0.770833741675442	0.721095705042184	0.79054053356998	0.519562897354641	0.774824710821936	0.886650808289969	0.889476046664135	0.535320364860859	p.Arg308=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R308S	308	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-2.244	-2.739	0.495	19.318	19.318	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
R308T	308	R	T	missense	wt-like	0.862558461475494	0.170469045859182	5	0.0762360749201321	0.713138500309338	1.01197842264165	NA	NA	1.04292795558256	0.912904573172231	0.688924202919075	NA	0.676866743994443	0.991168831709161	0.696052988289177	NA	NA	0.80555836338185	0.696052988289177	0.637468455322037	NA	0.65214322845051	0.791982162707444	p.Arg308Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-2.244	-2.62	0.376	21.662	21.662	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.445	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308V	308	R	V	missense	wt-like	0.913729264940097	0.202589736943875	8	0.0716262883959065	0.773344319337841	1.05411421054235	0.627270917359461	0.942486267517755	1.01275599015294	1.15881212659345	1.16683531361668	0.896205331088811	0.848474109814902	0.656994063376782	0.743631826483421	0.60555348861748	0.742693831114487	0.790760448643412	0.803896124836385	0.815986333407735	0.733056870513602	0.744569821852355	0.624143534625569	p.Arg308Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-2.244	-3.061	0.817	12.292	12.292	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R308W	308	R	W	missense	wt-like	0.864400291139919	0.195822133584185	6	0.0799440512707299	0.707712829871065	1.02108775240877	0.983743229659001	0.953877501124801	0.717613208439741	0.538368208940161	1.05467297209392	NA	NA	0.938126626581889	0.756643408171498	0.775154644433182	0.747944998097897	0.646006944611836	0.531799488517301	0.774089456014492	NA	NA	0.765341818245099	p.Arg308Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-2.244	-5.505	3.261	0.524	NA	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.79	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R308X	308	R	X	nonsense	low	0.0868315979644902	0.0894463753784932	8	0.031624069291345	0.024849561108855	0.148813634820126	0.195204895838163	0.00885828416392513	0.133191114743451	0.230869815680069	-0.00786455873333775	0.0689117437640517	0.0242663132433166	0.0412151750162831	0.342341072219187	0.399986620980567	0.31230704333558	0.359375689715639	0.396945594234547	0.377191494983995	0.325306454722736	0.300656948251971	0.314869784426058	p.Arg308Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R308Y	308	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg308Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-2.244	-4.339	2.095	3.73	NA	39.95	0.003092371	0	0.088385109	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.79	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A309C	309	A	C	missense	wt-like	1.02508739991118	0.152527517394139	2	0.107853241866945	0.813698930236078	1.23647586958628	NA	1.13294064177812	0.917234158044232	NA	NA	NA	NA	NA	0.787200811632179	NA	0.830490092385392	0.743911530878967	NA	NA	NA	NA	NA	p.Ala309Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.994	-5.023	3.029	1.656	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A309D	309	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.994	-2.991	0.997	15.948	15.948	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309E	309	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.994	-2.935	0.941	24.841	24.841	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.428571428571429
A309F	309	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.994	-3.259	1.265	10.808	10.808	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A309G	309	A	G	missense	wt-like	1.17803717251437	0.142937034001408	4	0.0714685170007042	1.0379614531645	1.31811289186424	NA	1.32321746520748	0.987610622201982	NA	1.23893422653916	NA	1.16238637610887	NA	0.87827944956972	NA	0.918204505711306	0.778427841015551	NA	0.8429180047146	NA	0.91364089442484	NA	p.Ala309Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.994	-2.432	0.438	45.546	45.546	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.51	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.428571428571429
A309H	309	A	H	missense	possibly_low	0.599676335845744	0.673921340146266	2	0.476534349603751	-0.334313826773827	1.53366649846531	NA	NA	NA	NA	NA	0.123141986241993	NA	1.07621068544949	0.593364664360289	NA	NA	NA	NA	NA	0.352035060211297	NA	0.834694268509281	p.Ala309His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.994	-3.407	1.413	16.164	16.164	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
A309I	309	A	I	missense	wt-like	1.24186777083593	0.0256680657371191	3	0.0148194646629027	1.21282215382647	1.27091338784538	NA	1.26610556665651	1.21497570336034	1.24452204249092	NA	NA	NA	NA	0.889939604918618	NA	0.891876881647373	0.889939604918618	0.841484340549909	NA	NA	NA	NA	p.Ala309Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.994	-3.894	1.9	6.311	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309K	309	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.994	-2.955	0.961	24.751	24.751	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309L	309	A	L	missense	possibly_wt-like	0.719573346325208	0.420303581178488	4	0.210151790589244	0.307683405483687	1.13146328716673	NA	0.15216803706746	NA	NA	0.652196641738998	NA	1.0053195020885	1.06860920440588	0.72639751787045	NA	0.378370427584171	NA	NA	0.623749321905031	NA	0.829045713835869	0.830876439425063	p.Ala309Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.994	-2.687	0.693	20.593	20.593	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309M	309	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.994	-3.437	1.443	8.079	8.079	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A309N	309	A	N	missense	wt-like	1.07445348763677	0.277835211770997	5	0.1242516840126	0.830924661953623	1.31798231331992	NA	0.912324256315642	1.24035522782409	1.41911968504359	0.705990999610127	NA	NA	1.0944772693904	0.843868624801	NA	0.728789651563659	0.902387055184747	0.918054405782414	0.643843549482454	NA	NA	0.843868624801	p.Ala309Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.994	-3.817	1.823	4.993	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309P	309	A	P	missense	wt-like	0.932261769793635	0.190798904451966	7	0.0721152073719252	0.790918560607025	1.07360497898025	0.751369082204044	0.953822012584143	1.0307951279989	0.712769038167699	1.21649389785767	NA	1.08286418053679	0.777719049206198	0.747919418814501	0.664596481484099	0.747919418814501	0.799607788218362	0.60828324096274	0.834535693087827	NA	0.870810765301757	0.684777424185596	p.Ala309Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.994	-2.629	0.635	43.458	43.458	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.715	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
A309Q	309	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.994	-3.173	1.179	18.792	18.792	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
A309R	309	A	R	missense	wt-like	1.0307798877709	0.102693704659353	5	0.0459260208959201	0.94076654086166	1.12079323468013	NA	1.10035789280021	1.0172116406481	1.05446073139453	0.861662174148397	NA	NA	1.12020699986324	0.792945733400069	NA	0.815469993459871	0.792945733400069	0.758132659644848	0.701992621842616	NA	NA	0.856791331937232	p.Ala309Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.994	-3.117	1.123	30.392	30.392	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
A309S	309	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.994	-2.509	0.515	19.973	19.973	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.715	Neutral	TOLERATED	neutral	DAMAGING	null	N	N	T	T	D	B	0.142857142857143
A309T	309	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.994	-2.547	0.553	21.052	21.052	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	0.92	Neutral	TOLERATED	neutral	DAMAGING	null	N	N	T	D	D	B	0.214285714285714
A309V	309	A	V	missense	wt-like	0.89978809477041	0.159086711269558	8	0.0562456461676854	0.789548653994564	1.01002753554626	0.740823704903136	0.979202011601695	1.02447863190949	1.00541586324364	0.951172362987939	0.614155861677076	0.816691693663158	1.06636462817714	0.736026010230322	0.659579238581812	0.759619171227403	0.796509847157983	0.736623957129002	0.735428063331642	0.594042389816217	0.727452022503003	0.829749105375469	p.Ala309Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.994	-3.554	1.56	6.123	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	D	0.428571428571429
A309W	309	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.994	-5.412	3.418	0.583	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.61	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A309X	309	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A309Y	309	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala309Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.994	-4.248	2.254	2.65	NA	86.35	0.003337536	0	0.095392347	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.61	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D310A	310	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.867	-2.692	0.825	15.885	15.885	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.295	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D310C	310	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.867	-5.11	3.243	1.529	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.19	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D310E	310	D	E	missense	possibly_wt-like	0.843698541280776	0.396536763893756	6	0.161885455965698	0.526408877967162	1.16098820459439	1.10824022593986	0.981386286910671	1.07195776003824	0.130119164826203	0.627836663985211	NA	NA	1.14265114598447	0.790211093921343	0.834387391932162	0.760626085384451	0.819796102458235	0.352761241025021	0.614649948733997	NA	NA	0.868063860716875	p.Asp310Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.867	-2.404	0.537	26.242	26.242	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.69	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
D310F	310	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.867	-4.312	2.445	1.97	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.19	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D310G	310	D	G	missense	wt-like	1.31214219489708	0.128452853168916	3	0.0741622893552491	1.16678677874976	1.45749761104441	NA	1.4574310040282	1.21364228911453	1.26535329154852	NA	NA	NA	NA	0.889285628618447	NA	0.980074688352988	0.889285628618447	0.850619916929374	NA	NA	NA	NA	p.Asp310Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.867	-2.499	0.632	41.497	41.497	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	1	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D310H	310	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.867	-2.727	0.86	13.88	13.88	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D310I	310	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.867	-3.078	1.211	11.926	11.926	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D310K	310	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.867	-3.59	1.723	6.721	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D310L	310	D	L	missense	possibly_wt-like	0.862914340914495	0.426386727361208	7	0.161159034705208	0.547048437109047	1.17878024471994	NA	1.13105439579592	1.21720813666939	1.14402057930569	0.926449297478051	0.994046083349885	0.622135977024325	0.00548591677820934	0.781279905270528	NA	0.829620564732283	0.891034507332037	0.797409268976511	0.726193063148958	0.781279905270528	0.622665598972702	0.296924833899162	p.Asp310Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.867	-3.578	1.711	7.361	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D310M	310	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.867	-4.806	2.939	1.659	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D310N	310	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.867	-2.664	0.797	14.461	14.461	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	2.19	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
D310P	310	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.867	-2.998	1.131	24.43	24.43	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D310Q	310	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.867	-3.917	2.05	5.755	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D310R	310	D	R	missense	wt-like	1.24347075903871	0.324690377031739	2	0.22959076738516	0.793481123780889	1.69346039429654	NA	NA	NA	NA	1.47306152642387	1.01387999165356	NA	NA	0.860714452354621	NA	NA	NA	NA	0.930373407700197	0.791055497009045	NA	NA	p.Asp310Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.867	-3.941	2.074	4.381	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D310S	310	D	S	missense	wt-like	1.03268481076135	0.121364686551104	3	0.0700699344503947	0.895350262839489	1.1700193586832	1.17207879900438	0.975492782570301	0.95048285070935	NA	NA	NA	NA	NA	0.760218434065986	0.864760285993767	0.757909279068619	0.760218434065986	NA	NA	NA	NA	NA	p.Asp310Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.867	-2.422	0.555	10.969	10.969	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.64	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D310T	310	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.867	-2.854	0.987	20.564	20.564	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.09	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D310V	310	D	V	missense	wt-like	1.03236157757006	0.129470537038365	2	0.0915494947036921	0.852927865147983	1.21179528999214	NA	0.940812082866368	1.12391107227375	NA	NA	NA	NA	NA	0.793599396268288	NA	0.741922060165987	0.84527673237059	NA	NA	NA	NA	NA	p.Asp310Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.867	-2.913	1.046	9.019	9.019	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.19	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D310W	310	D	W	missense	wt-like	1.18206556086138	0.0984831107759616	2	0.0696380754620284	1.04557744100312	1.31855368071964	1.25170363632341	NA	NA	NA	NA	NA	NA	1.11242748539935	0.877763999910889	0.902643913908171	NA	NA	NA	NA	NA	NA	0.852884085913608	p.Asp310Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.867	-5.529	3.662	0.47	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.19	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D310X	310	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D310Y	310	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp310Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.867	-4.249	2.382	2.275	NA	77.42	0.002802294	0	0.080094221	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.19	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N311A	311	N	A	missense	possibly_wt-like	0.799923530167628	0.207425615882263	4	0.103712807941132	0.596650161867491	1.00319689846777	1.08186920726048	NA	NA	NA	0.79698755894863	0.587442771521503	NA	0.733394582939898	0.670174876853005	0.821840680466108	NA	NA	NA	0.677834206578701	0.580876237213468	NA	0.662515547127308	p.Asn311Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.046	-2.517	0.471	26.019	26.019	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N311C	311	N	C	missense	possibly_low	0.459839950262802	0.405565128162486	4	0.202782564081243	0.0623934279708804	0.857286472554724	NA	0.364045750233895	0.981342073151725	NA	0.49365845265338	0.000313525012209338	NA	NA	0.520285899352262	NA	0.476042487545428	0.775353415698586	NA	0.564529311159096	0.291496266118437	NA	NA	p.Asn311Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.046	-5.13	3.084	1.925	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N311D	311	N	D	missense	wt-like	1.04638703947691	0.230543355080374	7	0.0871371977087329	0.875601270254049	1.21717280869977	NA	1.26008982251601	0.958011826330747	0.836041801322762	1.21781966291785	0.662363916189504	1.19900163382588	1.19138061323563	0.83503091648834	NA	0.889103724840924	0.763911038698359	0.662344701233184	0.83503091648834	0.617802823322629	0.933361630310119	0.892538140960737	p.Asn311Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.046	-3.573	1.527	4.327	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N311E	311	N	E	missense	wt-like	0.930467776578065	0.255730162255731	6	0.104401401560948	0.725844789583102	1.13509076357303	1.29521490551054	1.04057536918104	0.837424656187299	0.56916927197652	0.774572284031369	NA	NA	1.06585017258162	0.746340010180229	0.92334555409319	0.787911256184938	0.704768764175521	0.545307342182697	0.66946125348059	NA	NA	0.829490721052224	p.Asn311Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.046	-3.431	1.385	5.254	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N311F	311	N	F	missense	wt-like	0.981099451942377	0.228634406389422	8	0.0808344695852605	0.822666802845868	1.13953210103889	1.00604530816349	0.795732469223029	1.20948470570476	1.27861909238217	0.722697004182786	0.668507143815682	1.03562783412164	1.13208205794544	0.815567515462883	0.785765449707383	0.675042799902322	0.887246531597763	0.856437654330314	0.650083874138743	0.620830652447925	0.845369581218382	0.862755556785374	p.Asn311Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.046	-4.322	2.276	5.181	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N311G	311	N	G	missense	wt-like	0.946441025293436	0.1088571231909	8	0.0384868049943725	0.87100827362445	1.02187377696242	1.03163562224951	0.878026161224766	0.82264783414407	0.933984517900544	1.0971598001628	0.792259259898175	1.03516607471639	0.980648932051243	0.74983868524668	0.797940720259749	0.71297880694858	0.697521435418936	0.705297630538328	0.789959893473828	0.681824690792655	0.845120880653607	0.786698563544781	p.Asn311Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.046	-2.342	0.296	45.039	45.039	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N311H	311	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.046	-4.541	2.495	2.159	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N311I	311	N	I	missense	possibly_wt-like	0.714233485773912	0.336596947442808	4	0.168298473721404	0.3843745386269	1.04409243292092	0.699182880218612	NA	NA	NA	0.289333944864352	0.757646517780762	NA	1.11077060023192	0.652266263724254	0.639767511970967	NA	NA	NA	0.488206378389949	0.66476501547754	NA	0.852051918557653	p.Asn311Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.046	-4.106	2.06	4.363	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.44	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N311K	311	N	K	missense	wt-like	1.03589552909929	0.256261197085218	6	0.104618195622263	0.830847633552093	1.2409434246465	NA	NA	0.969085964475984	1.20654018344959	1.13690588664071	1.15851461690492	1.20072896715532	0.543597555969241	0.814816949001324	NA	NA	0.769342377019926	0.824827337729442	0.804806560273205	0.862341953821443	0.934291960628672	0.567190359113444	p.Asn311Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.046	-2.012	-0.034	13.682	13.682	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
N311L	311	N	L	missense	possibly_wt-like	0.929627819776922	0.400161843533331	6	0.16336538853135	0.609437541935083	1.24981809761876	0.420580702882001	1.08700501294588	1.1778424523116	NA	1.34968021461093	1.10939699469356	NA	0.433261541217555	0.82372387990332	0.507215137891054	0.809314540570103	0.871727510507267	NA	0.884285820516619	0.838133219236537	NA	0.511774310091079	p.Asn311Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.046	-3.607	1.561	5.381	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.095	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N311M	311	N	M	missense	wt-like	0.895968748313123	0.226915054252497	6	0.0926376829790967	0.714402226062854	1.07753527056339	1.06616751301031	0.934267067112182	0.742575457426232	1.0545864061018	NA	0.510279817696156	NA	1.06793622853205	0.748546346267223	0.814370183035566	0.738904918053035	0.658249741092674	0.75818777448141	NA	0.542844724594495	NA	0.830538438600051	p.Asn311Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.046	-4.763	2.717	1.634	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N311P	311	N	P	missense	wt-like	0.863392558109519	0.19332462998981	6	0.0789244496978989	0.708703479201994	1.01808163701704	NA	0.853646040032065	0.781483882899727	0.790384842235255	0.677739409716251	1.2371836014368	NA	0.839917572337014	0.689536227778575	NA	0.701739981385432	0.677332474171719	0.642321771458553	0.633290511966669	0.901115747845943	NA	0.716016511574179	p.Asn311Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.046	-2.764	0.718	27.131	27.131	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N311Q	311	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.046	-2.832	0.786	10.882	10.882	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N311R	311	N	R	missense	wt-like	1.01002478744561	0.110574608987091	8	0.0390940279209116	0.933401900710017	1.0866476741812	0.788365077409603	0.981873666313294	1.06979112391212	1.03649469216735	1.12042081573658	1.10197700655714	1.06133036867621	0.919945548792566	0.779749760893092	0.682198307294746	0.760850759086679	0.818733470435196	0.750253625452386	0.798648762699505	0.834476109724095	0.859212796509952	0.756210407251871	p.Asn311Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.046	-2.968	0.922	30.904	30.904	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.745	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N311S	311	N	S	missense	wt-like	1.04462209021309	0.210364948951945	7	0.079510477070235	0.888784418761827	1.20045976166434	1.02745862913957	0.677025153984299	1.18023351907632	1.31942688524456	1.03146841389315	1.17242151390556	0.904320516248143	NA	0.795953405018602	0.795953405018602	0.62032072536903	0.87290021508963	0.874333974783349	0.765421675753283	0.869196283555471	0.774648327373846	NA	p.Asn311Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.046	-2.583	0.537	19.427	19.427	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
N311T	311	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.046	-2.655	0.609	20.259	20.259	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.095	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
N311V	311	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.046	-3.705	1.659	6.134	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N311W	311	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.046	-5.416	3.37	1.085	NA	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N311X	311	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N311Y	311	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn311Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.046	-3.206	1.16	12.523	12.523	89.83	0.002601759	0	0.074362606	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D312A	312	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.306	-3.299	1.993	4.86	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
D312C	312	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.306	-5.221	3.915	0.624	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D312E	312	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.306	-2.117	0.811	26.242	26.242	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
D312F	312	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.306	-4.347	3.041	1.588	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D312G	312	D	G	missense	wt-like	0.956246277229154	0.213067445044735	8	0.075330717620612	0.808600783763197	1.10389177069511	0.470112535512924	0.967410283582571	0.996195987735268	0.949894981701634	1.15723007048761	0.950119127721371	1.01286873445338	1.14613849663848	0.771134031584256	0.53078122079293	0.754183383060169	0.782638554681395	0.712275188959607	0.812398411755535	0.759629508487116	0.833111680508969	0.869815375806807	p.Asp312Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.306	-2.251	0.945	27.96	27.96	88.34	0.002731599	0	0.078073652	4.064e-06	1	246060	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Jan 18, 2017)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D312H	312	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.306	-3.013	1.707	18.185	18.185	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D312I	312	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.306	-4.136	2.83	1.983	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D312K	312	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.306	-3.454	2.148	6.721	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D312L	312	D	L	missense	possibly_wt-like	0.770203000648244	0.236557277187978	8	0.0836356274193227	0.606280183081961	0.934125818214527	0.699097704047737	0.448408367539336	0.646143214468073	0.636151861570099	0.70728304199835	0.830787177049259	0.977112275427133	1.21664036308597	0.642026581669122	0.639726987148899	0.514932234337592	0.610954310085379	0.574682660082968	0.644326176189344	0.700814048958372	0.813853487924358	0.905224801242508	p.Asp312Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.306	-3.811	2.505	3.258	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D312M	312	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.306	-4.933	3.627	1.105	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D312N	312	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.306	-2.208	0.902	12.889	12.889	88.34	0.002731599	0	0.078073652	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Mar 10, 2016)	criteria provided, single submitter	0	0	1	0	0	1	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D312P	312	D	P	missense	wt-like	1.115782617605	0.0710520171941355	2	0.0502413631749564	1.01731135524789	1.21425387996211	1.16602398077996	NA	NA	NA	NA	1.06554125443004	NA	NA	0.83919873410913	0.861879545656621	NA	NA	NA	NA	0.816517922561639	NA	NA	p.Asp312Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.306	-3.832	2.526	2.312	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D312Q	312	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.306	-3.728	2.422	5.755	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D312R	312	D	R	missense	wt-like	0.948565770175057	0.11579243215539	7	0.0437654255980688	0.862787112234774	1.03434442811534	0.900904865623757	1.05845892134587	1.07434386068831	1.04900361621308	0.789601684212844	NA	0.941002049017384	0.826645394124152	0.75573943337148	0.735742095964471	0.796155272760628	0.820966371397442	0.75573943337148	0.675075302974818	NA	0.794404758564371	0.709350585855068	p.Asp312Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.306	-3.826	2.52	4.381	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D312S	312	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.306	-3.237	1.931	4.804	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D312T	312	D	T	missense	wt-like	1.03438910485312	0.0403477678164422	3	0.0232947946100234	0.988732146390215	1.08004606331602	NA	1.03537757800099	1.07423355390968	NA	NA	NA	NA	0.99355618264868	0.793181205078112	NA	0.785515161927471	0.820912271166251	NA	NA	NA	NA	0.793181205078112	p.Asp312Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.306	-3.522	2.216	3.333	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.145	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D312V	312	D	V	missense	possibly_wt-like	0.784320261182527	0.426131248089645	8	0.150660147599838	0.489031797981356	1.0796087243837	1.36607358066978	1.03580701705254	0.843021275777875	0.890286966323423	0.120193818746436	0.773959901445319	0.197588717339928	1.04763081210492	0.696823820990849	0.957058447891452	0.785713126102963	0.70751364003447	0.686134001947228	0.4250261431164	0.672805436767024	0.394007249937902	0.820340082653646	p.Asp312Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.306	-3.814	2.508	2.763	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D312W	312	D	W	missense	wt-like	0.967647063541326	0.13268121276034	6	0.054166878286081	0.861481932945642	1.07381219413701	NA	0.939215865471373	0.868703659511498	0.809870127751194	1.1803976359659	NA	1.05204543750694	0.955649655041045	0.757664478025696	NA	0.741186230810529	0.720109628375252	0.650867073452418	0.821052373835554	NA	0.854211993928761	0.774142725240864	p.Asp312Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.306	-5.503	4.197	0.431	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D312X	312	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D312Y	312	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp312Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.306	-4.264	2.958	2.981	NA	88.34	0.002731599	0	0.078073652	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K313A	313	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.898	-2.479	0.581	14.735	14.735	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.045	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K313C	313	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.898	-3.372	1.474	26.503	26.503	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.7	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K313D	313	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.898	-3.636	1.738	4.132	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K313E	313	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.898	-2.436	0.538	13.563	13.563	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
K313F	313	K	F	missense	possibly_low	0.644707145243634	0.280456541495659	7	0.106002608908397	0.436945849515891	0.852468440971377	0.535965957356917	0.867470760649064	0.907587194310082	0.786920831232775	0.427151898906653	0.156023946143757	NA	0.831829428106187	0.640802624094659	0.562112732592857	0.708112944925917	0.739180153761498	0.640802624094659	0.539686597550016	0.368241680240009	NA	0.711954256849789	p.Lys313Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.898	-3.193	1.295	10.808	10.808	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K313G	313	K	G	missense	wt-like	0.927150025383133	0.134796146810966	8	0.0476576347439259	0.833742777696673	1.02055727306959	0.990601394902351	1.05153976719768	0.968180751099696	1.06029140277632	0.81856338950625	0.68485373742003	0.827456013521125	1.01571374664161	0.764794061228093	0.778417598418427	0.792965659144629	0.768898412890587	0.760689709565598	0.685893595454303	0.628887442009767	0.733249614057439	0.804309798540651	p.Lys313Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.898	-2.546	0.648	41.624	41.624	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.045	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K313H	313	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.898	-4.676	2.778	2.159	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K313I	313	K	I	missense	wt-like	1.06217504085137	0.162207959066219	3	0.0936508088315813	0.878622828418428	1.24572725328432	0.964449120763735	NA	NA	NA	1.24941666757361	NA	0.972659334216774	NA	0.811455163209539	0.765974960468495	NA	NA	NA	0.846833592966769	NA	0.811455163209539	NA	p.Lys313Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.67	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.898	-3.963	2.065	4.769	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K313L	313	K	L	missense	possibly_wt-like	0.838930981561669	0.433199627652381	6	0.176853007418667	0.492305456463488	1.18555650665985	1.15417673201937	0.966575725630855	0.988730563488273	0.84676350402695	-0.018026628313481	NA	NA	1.09536599251805	0.766387892433376	0.856242902883246	0.75379866588967	0.778977118977083	0.667046720478464	0.3733955775889	NA	NA	0.844314984265041	p.Lys313Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.898	-2.845	0.947	15.561	15.561	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.045	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K313M	313	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.898	-4.657	2.759	2.065	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K313N	313	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.898	-3.767	1.869	3.443	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K313P	313	K	P	missense	wt-like	1.04883960694665	0.141860642518741	7	0.0536182829903462	0.943749703372698	1.15392951052061	NA	1.05487391829491	0.87880603903616	1.0903879910942	1.30100716799243	1.01873478246463	1.1005632641045	0.897504085639738	0.793448290815405	NA	0.79450264668816	0.725064365288563	0.773888614757467	0.866104596419071	0.793448290815405	0.880343374771502	0.744939225987897	p.Lys313Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.898	-3.006	1.108	22.343	22.343	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.59	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K313Q	313	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.898	-3.038	1.14	8.706	8.706	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.045	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K313R	313	K	R	missense	wt-like	0.901274574198179	0.219008968732104	5	0.0979437883534223	0.709308276516058	1.0932408718803	NA	1.13228873866514	0.965718190920255	0.856751804447497	0.551226656810092	NA	NA	1.00038748014791	0.767690644186933	NA	0.830189576021549	0.767690644186933	0.67142710502193	0.58603321307981	NA	NA	0.796612210973657	p.Lys313Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.898	-2.53	0.632	30.904	30.904	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.525	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
K313S	313	K	S	missense	wt-like	1.01356480539454	0.104929427076321	7	0.039659595608062	0.935833426361319	1.09129618442777	NA	0.879910751387325	1.02954522884634	1.07026910992163	1.0718064540451	1.16125431152007	1.008224430217	0.873943351824348	0.780489459642109	NA	0.713847571296698	0.798994772101318	0.76506544841188	0.780489459642109	0.863692274476144	0.830610288932694	0.733105893208434	p.Lys313Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.898	-2.805	0.907	7.04	7.04	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K313T	313	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys313Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.898	-2.877	0.979	10.801	10.801	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
K313V	313	K	V	missense	possibly_wt-like	0.75640285703797	0.219878696555591	2	0.155477717372918	0.451672130588554	1.06113358348739	NA	0.600925139665052	NA	NA	NA	NA	NA	0.911880574410888	0.668699844518366	NA	0.585239899497536	NA	NA	NA	NA	NA	0.752159789539196	p.Lys313Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.898	-3.61	1.712	3.971	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.845	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
K313W	313	K	W	missense	wt-like	0.969215167002086	0.0669676103248156	3	0.0386637678480182	0.893435574513352	1.04499475949082	NA	NA	NA	NA	1.04654269483107	0.930581610868006	0.930521195307185	NA	0.771052489907773	NA	NA	NA	NA	0.771052489907773	0.75	0.78875984000423	NA	p.Lys313Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.898	-5.381	3.483	0.502	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K313X	313	K	X	nonsense	low	0.00698539886041557	0.0832855143028635	2	0.058891751938164	-0.108440313924853	0.122411111645684	NA	-0.0519063530777484	NA	NA	NA	NA	NA	0.0658771507985795	0.305775891026432	NA	0.284295568209214	NA	NA	NA	NA	NA	0.327256213843649	p.Lys313Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K313Y	313	K	Y	missense	wt-like	0.990553947535329	0.00432458928129132	2	0.00305794640664775	0.984560482711646	0.996547412359013	NA	NA	NA	NA	0.993611893941977	NA	0.987496001128682	NA	0.785363463755111	NA	NA	NA	NA	0.751280833529447	NA	0.819446093980775	NA	p.Lys313Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.6	56.4	49.9	0	360	360	360	22.4	108.695652173913	-0.1	0	0	89.24	0	0	0	0	2	40.0248709911725	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.898	-4.249	2.351	2.507	NA	89.83	0.002423405	0	0.06926494	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E314A	314	E	A	missense	possibly_wt-like	0.837701749942971	0.269566196226729	6	0.110049938776408	0.622007833440373	1.05339566644557	NA	0.958172449855093	1.05624155502487	0.782913875027162	0.318752781511457	0.930581610868006	NA	0.979548227371235	0.749962448590235	NA	0.749924897180469	0.812088051010872	0.63904536727514	0.499195426722231	0.75	NA	0.786145736757954	p.Glu314Ala	1	0	NA	NA	NA	NA	NA	NA	NA	-2.278	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.843	-3.261	1.418	3.631	NA	85.11	0.002305459	0	0.065893861	4.067e-06	1	245886	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E314C	314	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.843	-3.31	1.467	21.227	21.227	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E314D	314	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.843	-2.004	0.161	35.636	35.636	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.44	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
E314E	314	E	E	synonymous	possibly_wt-like	0.822066336808244	0.532285749217096	6	0.217304747156156	0.396156858712596	1.24797581490389	NA	0.761324609280398	0.195654215893182	0.334164879214797	1.65945922740996	0.880724379791658	NA	1.10107070925947	0.692304043971074	NA	0.659181355537877	0.390010871479592	0.442245803546732	1	0.725426732404271	NA	0.847180167163961	p.Glu314=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E314F	314	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.843	-4.39	2.547	1.588	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E314G	314	E	G	missense	possibly_wt-like	0.740449130309557	0.335773954321904	8	0.11871402002342	0.507773926603687	0.973124334015427	0.265228942109032	1.11651040905323	0.994532537759918	0.948167361762819	0.635002633613342	0.436333374319249	0.440225862558209	1.08759192130065	0.664422124017252	0.433302417951784	0.822916031612789	0.781822711545014	0.711517538572821	0.617326709461684	0.506398542132605	0.524690013221719	0.840410472101393	p.Glu314Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.843	-3.485	1.642	4.225	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.645	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E314H	314	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.843	-3.184	1.341	18.185	18.185	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.645	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E314I	314	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.843	-4.105	2.262	2.068	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.995	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E314K	314	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.843	-2.029	0.186	14.163	14.163	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
E314L	314	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.843	-3.625	1.782	2.79	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.995	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E314M	314	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.843	-4.756	2.913	0.853	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E314N	314	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.843	-3.577	1.734	6.232	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.645	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
E314P	314	E	P	missense	wt-like	1.04584606995747	0.233277468697466	3	0.134682809348357	0.781872614298014	1.30981952561692	0.793917747182957	1.25437818844622	1.08924227424323	NA	NA	NA	NA	NA	0.828273335010333	0.684840137189889	0.88647075765903	0.828273335010333	NA	NA	NA	NA	NA	p.Glu314Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.843	-3.873	2.03	2.073	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.19	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E314Q	314	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.843	-2.667	0.824	8.44	8.44	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.645	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
E314R	314	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.843	-2.632	0.789	18.867	18.867	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E314S	314	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.843	-3.352	1.509	4.696	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E314T	314	E	T	missense	wt-like	1.05717645284771	0.282933068793345	5	0.126531514980909	0.809179240575835	1.30517366511958	NA	1.17065138360586	1.12890643979538	NA	1.10344621975778	0.571809851287819	1.31106836979169	NA	0.847726722671841	NA	0.847874109712824	0.847726722671841	NA	0.792308108992849	0.573171197765594	0.993720033863852	NA	p.Glu314Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.843	-2.828	0.985	7.872	7.872	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.995	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E314V	314	E	V	missense	possibly_wt-like	0.87069526902653	0.257419595455333	8	0.091011570778382	0.692315868124484	1.04907466992858	0.520133403105853	1.02762071309814	1.127884410337	1.19477476183704	0.773861373877423	1.01400134473727	0.756171608743544	0.551114536475976	0.738397841190068	0.55457997504663	0.78193937775187	0.847225465807396	0.819667593948312	0.669195701646052	0.791115308629856	0.694856304628267	0.5709657479672	p.Glu314Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.843	-3.711	1.868	2.421	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	1.995	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
E314W	314	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.843	-5.454	3.611	0.297	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
E314X	314	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	1	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E314Y	314	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu314Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.3	57	49.2	0.467	360	63.1	-142.5	-44.8	75.2336448598131	-0.3	0	0	78.49	0	0	0	0	3	39.246866854056	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.843	-4.252	2.409	2.981	NA	85.11	0.002305459	0	0.065893861	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y315A	315	Y	A	missense	possibly_wt-like	0.744987253276189	0.199493410557212	6	0.0814428438187874	0.585362212592845	0.904612293959533	NA	0.919856849629905	0.756567538645398	0.959845145907169	0.785659943798804	0.630728173961541	NA	0.417265867714318	0.669357552801658	NA	0.732262050311311	0.665112191779803	0.716638848807203	0.673602913823513	0.602210429951108	NA	0.503740514154222	p.Tyr315Ala	0	0	no	NA	NA	NA	NA	NA	NA	1.183	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.31	-3.287	0.977	5.664	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.4	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Y315C	315	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.31	-3.11	0.8	42.213	42.213	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y315D	315	Y	D	missense	possibly_low	0.626096867473785	0.124776786500622	5	0.055801875325874	0.516727201565278	0.735466533382292	NA	0.597632491013881	0.754945279459079	0.755369442920326	0.541121313579306	NA	0.481415810396332	NA	0.583722043883171	NA	0.583722043883171	0.664316550767327	0.626965714123028	0.582258485122022	NA	0.54687464698074	NA	p.Tyr315Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.31	-3.782	1.472	7.32	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.4	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
Y315E	315	Y	E	missense	possibly_wt-like	0.783805404181787	0.181933502669283	4	0.0909667513346413	0.605513847775279	0.962096960588294	NA	0.836472161249835	0.75271306211689	0.991336942387069	NA	NA	NA	0.554699450973352	0.678522433285507	NA	0.69382311229563	0.663221754275384	0.730449624688826	NA	NA	NA	0.572766264307895	p.Tyr315Glu	0	0	no	NA	NA	NA	NA	NA	NA	3.912	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.31	-2.976	0.666	14.3	14.3	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.05	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y315F	315	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Phe	1	0	no	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.31	-2.856	0.546	32.042	32.042	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
Y315G	315	Y	G	missense	low	0.594454590261983	0.132994036652461	7	0.0502670209767171	0.495933039537498	0.692976140986468	0.83305172488761	0.488635147860326	0.56381845991189	0.586239653599072	0.687410802917214	NA	0.427227593516993	0.574798749140775	0.570577931502192	0.703459164871337	0.533476103066597	0.570577931502192	0.552793584352252	0.636903143173021	NA	0.517689231397137	0.582861097758856	p.Tyr315Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.31	-2.884	0.574	36.816	36.816	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.4	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y315H	315	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.31	-2.421	0.111	15.549	15.549	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
Y315I	315	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.31	-3.764	1.454	6.739	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y315K	315	Y	K	missense	possibly_wt-like	0.722475607082644	0.209217149522584	5	0.0935647536782473	0.539092059650918	0.90585915451437	0.897868742068939	0.386008623288451	0.764139561178523	0.887653852208914	NA	NA	NA	0.676707256668393	0.668825908876028	0.734297579668732	0.486167002398111	0.668825908876028	0.684979245694138	NA	NA	NA	0.634044447652869	p.Tyr315Lys	0	0	NA	NA	NA	NA	NA	NA	NA	4.916	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.31	-3.669	1.359	7.133	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.85	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y315L	315	Y	L	missense	possibly_wt-like	0.815866273273353	0.204231944799083	4	0.102115972399542	0.615722645123966	1.01600990142274	NA	0.879448652240995	1.07139558561056	0.705696547567814	0.606924307674044	NA	NA	NA	0.660236471977131	NA	0.713634551367165	0.819520382625918	0.605181589309992	0.606838392587097	NA	NA	NA	p.Tyr315Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.31	-2.635	0.325	21.99	21.99	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y315M	315	Y	M	missense	wt-like	1.12357776560078	0.107534638759915	8	0.0380192361397907	1.04906143204706	1.19809409915449	1.08661137516599	1.20459756516065	1.06635569626622	1.08890090255434	1.30420658878009	1.01897276884374	1.22033159360144	0.998645634433728	0.820572724545565	0.824096892604036	0.863522728110321	0.817048556487094	0.773236449786398	0.867299701109738	0.793565587802257	0.94484980571581	0.795737372348173	p.Tyr315Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.31	-3.404	1.094	8.079	8.079	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y315N	315	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.31	-3.046	0.736	27.821	27.821	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.05	Neutral	TOLERATED	effect	DAMAGING	null	D	D	T	T	D	D	0.571428571428571
Y315P	315	Y	P	missense	wt-like	0.896853770349274	0.206191681663976	5	0.0922117233191296	0.716122113691407	1.07758542700714	0.554152608843517	0.893322245153514	0.930822643484927	1.01627565391908	NA	NA	NA	1.08969570034533	0.741386535066894	0.570765514326864	0.720030044213386	0.750576037022756	0.741386535066894	NA	NA	NA	0.841467091038869	p.Tyr315Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.31	-4.132	1.822	1.95	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y315Q	315	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.31	-3.173	0.863	16.881	16.881	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.7	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y315R	315	Y	R	missense	possibly_low	0.695581758409859	0.261135512321132	6	0.106608126484507	0.486633670040935	0.904529846778784	NA	0.412741430981831	1.03769941042968	0.646988716587722	0.984323804885727	NA	0.6275824968074	0.464154690766793	0.602517119047439	NA	0.498490376843395	0.802994010537193	0.579435179552778	0.747811380920629	NA	0.625599058542101	0.527290334425732	p.Tyr315Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.31	-3.124	0.814	15.708	15.708	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y315S	315	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.31	-2.723	0.413	11.242	11.242	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
Y315T	315	Y	T	missense	possibly_low	0.687086975905492	0.287691035699509	6	0.117449373506103	0.456890433826738	0.917283517984246	0.959507402390561	0.902251998114778	0.760699479160469	0.791981893210284	0.188118594247286	NA	NA	0.519962488309572	0.655080436402339	0.763623806903722	0.724146510044724	0.66713871217964	0.643022160625038	0.4503986161986	NA	NA	0.555319692305124	p.Tyr315Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.31	-2.74	0.43	13.486	13.486	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.425	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y315V	315	Y	V	missense	possibly_wt-like	0.815146947168601	0.166716782577101	7	0.063013020868548	0.691643695709176	0.938650198628026	1.14258473143401	0.681663079384926	0.736797893131681	0.678141411297067	0.771636541387732	NA	0.767525969012996	0.927679004531796	0.668364642551033	0.850727701198125	0.62245873092448	0.655416120458114	0.593097241830299	0.668364642551033	NA	0.700971688049866	0.760094520370529	p.Tyr315Val	0	0	NA	NA	NA	NA	NA	NA	NA	2.93	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.31	-2.936	0.626	7.549	7.549	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y315W	315	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.31	-5.11	2.8	1.489	NA	87.84	0.002486015	0	0.071054437	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y315X	315	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr315Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	38.7	59.7	46.6	0.379	83.3	-100	-92.1	168.1	24.7058823529412	-0.8	0	0	60.75	0	0	0	0	5	35.5705881011265	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	3	0	0	0	0	1	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L316A	316	L	A	missense	wt-like	1.15045761053678	0.156691859441608	5	0.0700747298464556	1.01311366381136	1.28780155726221	NA	1.1189714197395	1.06555305401487	1.22903269499414	1.3732283067269	NA	0.965502577208516	NA	0.824050516121433	NA	0.824050516121433	0.816654898618543	0.834691463332911	0.893081923690225	NA	0.807600581170385	NA	p.Leu316Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.626	-3.267	1.641	3.644	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L316C	316	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.626	-4.877	3.251	0.912	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L316D	316	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.626	-3.987	2.361	1.858	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L316E	316	L	E	missense	wt-like	0.771724860355084	0.0331970051183582	6	0.0135526205880898	0.745162212106292	0.798287508603876	NA	0.78137679278055	0.727866771479237	0.780586776427184	0.734574437744621	0.796567698227363	NA	0.809376685471548	0.66147280976559	NA	0.668425074662042	0.651035829852261	0.63802481459758	0.654520544869139	0.68394820238159	NA	0.700677410487992	p.Leu316Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.626	-3.779	2.153	2.944	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L316F	316	L	F	missense	wt-like	1.38353487172085	0.151250162355674	2	0.106950015457263	1.17391669327861	1.59315305016309	NA	1.49048488717811	1.27658485626359	NA	NA	NA	NA	NA	0.957733968932598	NA	0.995311972202823	0.920155965662373	NA	NA	NA	NA	NA	p.Leu316Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.626	-2.545	0.919	18.555	18.555	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L316G	316	L	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.626	-3.719	2.093	2.142	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L316H	316	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.626	-3.102	1.476	16.164	16.164	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L316I	316	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.626	-2.297	0.671	13.543	13.543	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
L316K	316	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.626	-2.836	1.21	11.482	11.482	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.135	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L316L	316	L	L	synonymous	wt-like	1.06383189025967	0.15229800251037	5	0.0681097372901243	0.930339258174539	1.1973245223448	NA	0.942411211339107	0.969792428011456	NA	1.28027584377629	NA	1.16903732461013	0.957642643561352	0.775143699852743	NA	0.742659231479293	0.769688863800448	NA	0.858360662607679	NA	0.917223051344059	0.775143699852743	p.Leu316=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L316M	316	L	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.626	-4.256	2.63	1.842	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L316N	316	L	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.626	-4.001	2.375	2.491	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L316P	316	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.626	-4.157	2.531	1.324	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	not specified	Uncertain significance(Last reviewed: Mar 24, 2017)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L316Q	316	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.626	-4.137	2.511	2.207	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.857142857142857
L316R	316	L	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.626	-3.951	2.325	4.442	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L316S	316	L	S	missense	wt-like	1.118463786364	0.198607869895307	5	0.0888201395904681	0.944379511664867	1.29254806106314	NA	1.13314860392427	0.883539702787242	1.01010443911257	1.41812391186496	NA	1.14740227413097	NA	0.830585959434856	NA	0.830585959434856	0.727386002331147	0.738680139302385	0.909852130503207	NA	0.905570556101184	NA	p.Leu316Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.626	-3.614	1.988	4.607	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L316T	316	L	T	missense	possibly_wt-like	0.833867996178169	0.522724145389615	6	0.213401238739494	0.415609253992527	1.25212673836381	NA	1.23949587248286	1.10088366990988	1.12463945714273	0.254966525950656	0.0773546216871795	NA	1.2058678298957	0.811446267080845	NA	0.879610260462739	0.833982886180056	0.788909647981633	0.475368847388002	0.32946771867591	NA	0.899814317379098	p.Leu316Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.626	-2.756	1.13	12.265	12.265	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.48	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L316V	316	L	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.626	-3.12	1.494	8.792	NA	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.825	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
L316W	316	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.626	-3.115	1.489	25.258	25.258	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L316X	316	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L316Y	316	L	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu316Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	37.9	63.4	46.5	0.713	40.9	-152.6	-84.1	132.1	16.2303664921466	-6.4	0	1	45.4	0	0	0	0	6	32.5917007512649	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.626	-2.553	0.927	20.399	20.399	64.27	0.002446709	0	0.069931021	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.13	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V317A	317	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.9	-2.534	0.634	24.797	24.797	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.24	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
V317C	317	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.9	-4.809	2.909	1.834	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V317D	317	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.9	-3.855	1.955	3.328	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V317E	317	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.9	-3.684	1.784	3.597	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	D	D	D	0.928571428571429
V317F	317	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.9	-2.952	1.052	19.703	19.703	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.585	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V317G	317	V	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.9	-3.588	1.688	6.709	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.24	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V317H	317	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.9	-4.853	2.953	1.305	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V317I	317	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.9	-1.861	-0.039	24.66	24.66	86.35	0.002796787	0	0.079936822	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Mar 5, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.65	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	T	B	0.214285714285714
V317K	317	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.9	-2.594	0.694	12.65	12.65	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.035	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V317L	317	V	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.9	-2.916	1.016	15.221	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	low	1.435	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
V317M	317	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.9	-3.136	1.236	7.315	7.315	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V317N	317	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.9	-3.945	2.045	3.925	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V317P	317	V	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.9	-3.999	2.099	2.488	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V317Q	317	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.9	-4.109	2.209	2.431	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V317R	317	V	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.9	-3.949	2.049	4.894	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V317S	317	V	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.9	-2.756	0.856	9.659	9.659	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.585	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V317T	317	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.9	-2.302	0.402	21.967	21.967	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
V317W	317	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.9	-5.298	3.398	0.915	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
V317X	317	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V317Y	317	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val317Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64.1	44.5	0.904	15.5	-172.5	-117.2	138	43.030303030303	-1.2	0	1	39.33	0	0	0	0	5	30.6421307656632	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.9	-4.051	2.151	4.57	NA	86.35	0.002796787	0	0.079936822	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.585	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318A	318	L	A	missense	wt-like	0.850129471886048	0.169681591521947	8	0.0599915020038473	0.732548288580045	0.967710655192051	0.935575949835723	0.773442060458946	0.642349048996635	0.595244030655962	0.980247648719906	0.821051834747634	1.03625792575595	1.01686727591763	0.721152273505833	0.752237783715928	0.664767296599828	0.609093452287407	0.556742467788156	0.746288782401407	0.69601576461026	0.845708944409533	0.804889156378185	p.Leu318Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.177	-3.085	1.908	5.585	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318C	318	L	C	missense	wt-like	0.893888134918842	0.149266266806897	8	0.0527735947307787	0.790453789911803	0.997322479925881	1.03317307944028	0.815694566540606	0.958633797264555	0.833627448043425	1.01302611791208	1.04724626297658	0.607025806467059	0.842678000706151	0.737967855967574	0.79867220628987	0.684244990812431	0.764216085874346	0.661285882881514	0.758532780576177	0.807500820910745	0.614527360945145	0.717402931358971	p.Leu318Cys	0	0	NA	NA	NA	NA	NA	NA	NA	3.151	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.177	-4.728	3.551	0.958	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318D	318	L	D	missense	possibly_low	0.568807359797669	0.746375471825899	3	0.430920079575217	-0.27578047638489	1.41339519598023	NA	NA	NA	NA	-0.0288977073849817	1.40537527762258	NA	0.329944509155411	0.459883531486412	NA	NA	NA	NA	0.36933481832864	0.984012831720463	NA	0.459883531486412	p.Leu318Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.177	-3.989	2.812	2.504	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318E	318	L	E	missense	possibly_wt-like	0.781836212078417	0.310576878634648	4	0.155288439317324	0.477476463801028	1.08619596035581	0.873024209706216	0.964471103890243	NA	NA	0.320722862198945	NA	0.969126672518265	NA	0.737652802617802	0.722477134548501	0.752828470687104	NA	NA	0.499931326382473	NA	0.809552494959413	NA	p.Leu318Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.177	-3.799	2.622	2.638	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318F	318	L	F	missense	possibly_low	0.681823695145703	0.130799113974793	8	0.0462444702323842	0.591186199006095	0.772461191285311	0.400594175041284	0.781213665535848	0.702546010465509	0.704349889399162	0.764811954131936	0.604534167839589	0.68438440674928	0.812155292003017	0.647404696102557	0.497706017250907	0.668349875747594	0.638617200264888	0.604591010294651	0.665815401053096	0.589300119692337	0.656192191940227	0.702072960219494	p.Leu318Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.177	-2.648	1.471	15.973	15.973	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.855	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L318G	318	L	G	missense	low	0.449298321379151	0.110793785299031	8	0.0391715184491355	0.372523555999099	0.526073086759203	0.449333444318089	0.444777890640738	0.538545723572432	0.615779412919951	0.253521029364174	0.348583248015269	0.452826659269202	0.491019162933355	0.526185868097286	0.520895017119186	0.513258645586664	0.558182855734567	0.565748291329293	0.474828899733255	0.463148901334769	0.531476719075387	0.540782963372795	p.Leu318Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.177	-3.654	2.477	3.425	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318H	318	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu318His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.177	-4.67	3.493	1.894	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.855	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L318I	318	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu318Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.177	-3.065	1.888	8.434	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.855	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
L318K	318	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu318Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.177	-3.694	2.517	2.77	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318L	318	L	L	synonymous	wt-like	0.922082103645513	0.244873634525997	7	0.0925535342274725	0.740680509917772	1.10348369737325	0.407623601617916	0.926058982068717	0.947718051559477	1.00647237363691	1.1058393278906	NA	1.1530495607898	0.907812827955158	0.750116771785576	0.501050453357117	0.73512112898645	0.75886243151507	0.737087291390271	0.793202025406044	NA	0.908612147383376	0.750116771785576	p.Leu318=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L318M	318	L	M	missense	possibly_wt-like	0.855683163615414	0.427547326522929	7	0.161597699955743	0.538957491717649	1.17240883551318	0.981173019658881	1.18956517299043	1.13214307934417	1.22457560265506	0.29886148378449	0.196443234268783	NA	0.967020552606081	0.779853736448858	0.773931798866587	0.85659304830838	0.849314140508235	0.832736798618307	0.491765274580747	0.38816324350541	NA	0.779853736448858	p.Leu318Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.177	-4.026	2.849	1.629	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.855	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L318N	318	L	N	missense	low	0.52543635995462	0.140110900585274	7	0.0529569427025614	0.421642659526248	0.629230060382991	0.529412220617609	0.541072991762907	0.641819377216815	0.71859113158281	0.504148101058244	NA	0.274475456060638	0.468535241383316	0.558994618541506	0.558994618541506	0.5576490665999	0.608833673458765	0.610836529002986	0.568447591636752	NA	0.435417939413596	0.529490457461321	p.Leu318Asn	0	0	NA	NA	NA	NA	NA	NA	NA	2.768	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.177	-4.011	2.834	2.811	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318P	318	L	P	missense	low	0.356731718348031	0.208960160948466	4	0.104480080474233	0.151954523516688	0.561508913179375	NA	0.305584133554429	0.528656825996925	0.510264815909824	NA	NA	NA	0.0824210979309476	0.484283684165067	NA	0.44909266613942	0.553332821568883	0.519474702190714	NA	NA	NA	0.335565379145423	p.Leu318Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.177	-4.093	2.916	1.488	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	2	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L318Q	318	L	Q	missense	possibly_wt-like	0.85374236593199	0.288959800812613	8	0.102162717322456	0.653507119417229	1.05397761244675	0.747260989265301	0.194039403167818	0.913338586998688	0.967870496093867	0.951001446005819	1.12828406835999	0.886022543658559	1.04212139390588	0.738682578920458	0.662641947326552	0.397672422679811	0.742000938467479	0.720158378500301	0.735364219373437	0.847442142040425	0.764793160233847	0.817572988068167	p.Leu318Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.177	-4.112	2.935	1.691	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318R	318	L	R	missense	possibly_low	0.613827207982774	0.137785538587262	8	0.0487145443422468	0.518348455548691	0.709305960416858	0.842637929126106	0.536048378666501	0.643796121343913	0.803561025958268	0.516695110526463	0.476434403608769	0.54413151230694	0.547313182325236	0.576893641978392	0.708020055753006	0.55533280452448	0.609803172483306	0.648100207137501	0.573134374296645	0.526163244309639	0.580652909660139	0.569056525231153	p.Leu318Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.177	-3.998	2.821	2.024	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L318S	318	L	S	missense	possibly_wt-like	0.849896551385063	0.194574656312744	5	0.0870164316427907	0.679347479302002	1.02044562346812	0.903403459638941	1.00818039189622	0.51470643012142	0.869439956015977	NA	NA	NA	0.953752519252759	0.736930868327059	0.736930868327059	0.772977716849818	0.546490815561196	0.676991513447349	NA	NA	NA	0.773189892477397	p.Leu318Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.177	-2.66	1.483	11.242	11.242	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318T	318	L	T	missense	possibly_wt-like	0.70701897586957	0.139046916352078	7	0.0525547944625714	0.604013471508025	0.810024480231115	NA	0.736213101193648	0.73947581705897	0.758825629839922	0.475902404257034	0.578077184071027	0.756266061650491	0.9043726330159	0.647605372925491	NA	0.647605372925491	0.656729514842198	0.628481430223315	0.557896755414	0.576260194933476	0.694907176339887	0.748388940561751	p.Leu318Thr	0	0	NA	NA	NA	NA	NA	NA	NA	1.748	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.177	-3.429	2.252	4.198	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318V	318	L	V	missense	wt-like	0.903112263945604	0.203851701957567	7	0.0770487011024259	0.752099584729258	1.05412494316195	0.986852939388532	0.786909503879611	1.08997569367595	1.03286048838218	1.06116740876859	NA	0.517220587400754	0.8467992261236	0.748659839781345	0.776634171302962	0.670975561365621	0.828633042377037	0.748659839781345	0.776515373781568	NA	0.566158863309157	0.719472808817203	p.Leu318Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.177	-2.406	1.229	13.829	13.829	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.2	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L318W	318	L	W	missense	low	0.55855469054821	0.128937337438887	8	0.0455862328255874	0.469207316019201	0.647902065077219	0.495477573333962	0.305946158133202	0.626262983967434	0.603753419746976	0.748885231751235	0.624073510831593	0.528143419407954	0.535895227213324	0.567681853960768	0.542849310188165	0.44925955337752	0.601204002084557	0.560474273488746	0.659866167773894	0.598930528233317	0.572041828459863	0.563321879461674	p.Leu318Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.177	-4.959	3.782	1.105	NA	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L318X	318	L	X	nonsense	low	-0.0734620936282006	0.175744479036676	3	0.101466122280415	-0.272332038948752	0.12540785169235	NA	NA	NA	NA	-0.259906910476817	0.08914957631824	-0.0496289467260245	NA	0.283044142445366	NA	NA	NA	NA	0.283044142445366	0.335281129693154	0.26085744946673	NA	p.Leu318Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L318Y	318	L	Y	missense	wt-like	0.953541441008418	0.157093746277183	8	0.0555410266372975	0.844683029134935	1.0623998528819	0.613445254445057	1.0021089010853	0.969037268155209	1.10037145048454	0.865403033135973	1.00175421243721	1.10341515877718	0.972796249546869	0.774222869013084	0.598975562845139	0.770178861766496	0.769318493789495	0.778266876259673	0.70338997418227	0.78507903158854	0.88187938639942	0.782754569014992	p.Leu318Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	33.6	67.2	42.5	0.99	9.7	-160	-126.3	122.3	20.9424083769633	-6.7	0	1	31.69	0	0	0	0	5	27.0213311637306	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.177	-2.7	1.523	12.759	12.759	51.12	0.003247971	0	0.092832432	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.2	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T319A	319	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr319Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.656	-2.455	0.799	25.804	25.804	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.9	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
T319C	319	T	C	missense	wt-like	1.06443602226353	0.127602773914668	7	0.0482293151971732	0.969908301478042	1.15896374304902	NA	1.31878001869142	1.07377420807559	0.997644496930325	1.09149872400134	0.904260263648924	1.02847446096794	1.03661998352918	0.814809915395899	NA	0.916158917547667	0.820686983870857	0.733215812455016	0.787845267382482	0.737026926792141	0.841516821700933	0.814809915395899	p.Thr319Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.656	-4.84	3.184	1.909	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.555	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T319D	319	T	D	missense	possibly_low	0.644875509674516	0.139576636308209	4	0.0697883181541044	0.508092919550848	0.781658099798183	NA	0.745690193794846	0.764265430208069	0.464836362284813	NA	NA	NA	0.604710052410335	0.624929072413329	NA	0.651974153119355	0.668887641651501	0.499551983838834	NA	NA	NA	0.597883991707302	p.Thr319Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.656	-3.607	1.951	4.357	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T319E	319	T	E	missense	possibly_wt-like	0.959458942181789	0.306050782513531	5	0.136870070853452	0.691198532747578	1.227719351616	NA	1.08735282928428	1.0714050754457	0.452678330564528	1.25621474674449	NA	0.929643728869945	NA	0.809474878048511	NA	0.809474878048511	0.819525036938929	0.494220060289865	0.849372932692253	NA	0.788287242378652	NA	p.Thr319Glu	0	0	NA	NA	NA	NA	NA	NA	NA	-0.527	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.656	-2.718	1.062	14.3	14.3	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T319F	319	T	F	missense	low	0.509712561097409	0.247144193032322	7	0.0934117246767524	0.326628944997203	0.692796177197615	NA	0.821213583704573	0.564079216297545	0.418671594752925	0.123671860374731	0.43910488460315	0.391264838622041	0.809981949326901	0.507764543861549	NA	0.686789164842394	0.570705820113606	0.479306353888282	0.426325323230607	0.507764543861549	0.498319929220658	0.700981403083295	p.Thr319Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.656	-4.147	2.491	3.112	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T319G	319	T	G	missense	possibly_wt-like	0.741824607852329	0.0909574766304875	8	0.0321583242625173	0.678795450494635	0.804853765210023	0.803158287350884	0.724828434856062	0.69707582127382	0.758858351398138	0.610437812883125	0.824971830202731	0.641672448916341	0.87359387593753	0.639145782924583	0.689236569223368	0.642357233342778	0.635934332506387	0.628495780313101	0.60815081969023	0.697947823314937	0.633187813654087	0.732930369623323	p.Thr319Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.656	-3.444	1.788	6.981	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.9	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T319H	319	T	H	missense	possibly_low	0.632096312681855	0.314131080755863	6	0.128243476700147	0.380743717097366	0.883448908266345	NA	0.974589843036442	0.68987084660186	0.90841639137505	0.25398398150306	0.249527806147638	NA	0.716189007427081	0.643137357597243	NA	0.757493039139584	0.632400634937465	0.694084689244808	0.475001829869506	0.414327179243964	NA	0.653874080257021	p.Thr319His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.656	-4.707	3.051	1.687	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T319I	319	T	I	missense	possibly_wt-like	0.82749204356593	0.158063876132066	5	0.0706883143636814	0.688945493285269	0.96603859384659	0.734582141099468	NA	0.952747108924086	NA	0.6722838644917	1.0372111694024	NA	0.740635933911991	0.666152501582848	0.656609649083063	NA	0.761328945082765	NA	0.631252659455005	0.802554797346603	NA	0.666152501582848	p.Thr319Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.656	-2.525	0.869	15.901	15.901	89.08	0.003292755	0	0.094112426	8.132e-06	2	245952	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.555	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T319K	319	T	K	missense	possibly_wt-like	0.853621212234713	0.282741208538908	5	0.126445712466688	0.605792169800496	1.10145025466893	0.781078687441353	1.01456942783001	0.909861442056724	1.15209431001293	NA	NA	NA	0.410502193832543	0.740295564168798	0.678731614040599	0.775922954890639	0.740295564168798	0.800950016021459	NA	NA	NA	0.500343472089151	p.Thr319Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.656	-3.459	1.803	6.024	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T319L	319	T	L	missense	possibly_wt-like	0.744334284088325	0.265486522603311	8	0.0938636602232184	0.560364890593712	0.928303677582938	0.931300782474486	0.879132409498658	0.728911281960789	0.959367625850989	0.757277761062755	0.122555322261045	0.748213821969939	0.827915267627936	0.700279335302463	0.750203759471256	0.713488768785173	0.651548112589873	0.716429431650608	0.663001094941161	0.351745909556891	0.69057029324999	0.709988377354936	p.Thr319Leu	0	0	NA	NA	NA	NA	NA	NA	NA	1.686	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.656	-3.16	1.504	11.451	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.555	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T319M	319	T	M	missense	wt-like	1.03431479167888	0.124465947939565	6	0.0508130104672916	0.934723121216927	1.13390646214082	NA	0.955994158412788	0.891264894397326	1.21464978363214	1.15679913783643	NA	0.990320237147507	0.996860538647067	0.803539126783493	NA	0.74892074148525	0.73117484157832	0.828383815388066	0.812237442109162	NA	0.820967208840472	0.794840811457825	p.Thr319Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.656	-4.49	2.834	2.793	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T319N	319	T	N	missense	possibly_low	0.633473422845564	0.179314323021827	7	0.0677744436039513	0.500637954309578	0.76630889138155	NA	0.700326033633449	0.591475122153757	0.394483456939333	0.560369456242105	0.550404505263307	0.662480993210979	0.974774392476019	0.589448394518014	NA	0.63106203874376	0.584142209598677	0.468698608771215	0.589448394518014	0.562621087290465	0.6443951581268	0.783748087457557	p.Thr319Asn	1	0	NA	NA	NA	NA	NA	NA	NA	2.703	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.656	-3.722	2.066	4.802	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.9	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T319P	319	T	P	missense	possibly_wt-like	0.727899818156855	0.147645391314493	8	0.0522005287047097	0.625588661921674	0.830210974392035	0.663003683655966	0.680997622305777	0.764445346643956	0.943136084535751	0.43897669335758	0.732289820823157	0.752334105357427	0.848015188575223	0.660621637074722	0.622554299775255	0.622151966410341	0.668975882110496	0.709311064190652	0.544103605581274	0.652267392038949	0.692789450659318	0.720083523595873	p.Thr319Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.656	-2.788	1.132	24.675	24.675	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.555	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
T319Q	319	T	Q	missense	wt-like	1.05681111849949	0.0866296192757133	5	0.0387419435130842	0.980878304522762	1.13274393247622	0.959701219724111	1.02556111851972	1.04644735718225	1.19646638465862	NA	NA	NA	1.05587951241276	0.807284462562361	0.763716020639973	0.780989939313289	0.807284462562361	0.820409457743859	NA	NA	NA	0.824482976355749	p.Thr319Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.656	-3.915	2.259	3.136	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T319R	319	T	R	missense	possibly_low	0.636291089105437	0.288500502549842	8	0.10200033086436	0.436374114200122	0.836208064010752	1.20393076525432	0.447730512291308	0.569205601374874	0.656179995520267	0.72861945785016	0.17717395955926	0.649296387383316	0.65819203360999	0.604105620970903	0.879914703614993	0.514619754476256	0.573220068297658	0.583466029094305	0.652296134615837	0.378665944245296	0.637294016540186	0.624745212847501	p.Thr319Arg	0	0	NA	NA	NA	NA	NA	NA	NA	2.732	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.656	-2.597	0.941	17.159	17.159	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T319S	319	T	S	missense	possibly_wt-like	0.818139458957342	0.181079260003035	8	0.064021186340194	0.692660239483034	0.94361867843165	1.10293783667596	0.984761977259805	0.772427000210494	0.712339163794171	0.525055263041962	0.711949188640903	0.919105295162799	0.816539946872641	0.688582824181968	0.831864639626548	0.762182221824021	0.672890503755708	0.608094718893704	0.576257207505861	0.642242049939316	0.782611311612593	0.704275144608228	p.Thr319Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.656	-2.62	0.964	19.209	19.209	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	medium	2.35	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
T319T	319	T	T	synonymous	wt-like	0.86705934422082	0.0792469660174535	3	0.0457532571626379	0.777384608006651	0.95673408043499	NA	0.954896968992237	0.845355287716242	NA	NA	NA	NA	0.800925775953981	0.708658361936761	NA	0.748414955627591	0.708658361936761	NA	NA	NA	NA	0.696432957603202	p.Thr319=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T319V	319	T	V	missense	wt-like	0.896190423826103	0.186902136522205	7	0.0706423675349138	0.75773392767503	1.03464691997718	NA	0.919087838502388	1.08536249066217	1.01735505798255	0.614003449377623	1.10714766910971	0.773779610543485	0.7565968506048	0.731907549123644	NA	0.731907549123644	0.826370485599676	0.741859909382513	0.60948271980047	0.837024588085374	0.704339858059678	0.674168840979201	p.Thr319Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.656	-2.364	0.708	23.716	23.716	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T319W	319	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr319Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.656	-5.365	3.709	0.484	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.9	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T319X	319	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr319Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T319Y	319	T	Y	missense	possibly_low	0.682302937613596	0.166615693030343	7	0.0629748126112808	0.558874572962326	0.805731302264865	0.832301437734519	0.712359782313407	0.751283829840376	0.781173261118777	0.622205420215723	NA	0.742848082716514	0.333948749355853	0.638282018362973	0.703102195861495	0.636609394362537	0.66252078378612	0.638282018362973	0.612546466169541	NA	0.687680341540135	0.461894653346708	p.Thr319Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.1	67.4	41.1	0.911	2.8	-166.1	-109.9	126.9	36.1963190184049	-1.3	0	1	30.6	0	0	0	0	5	26.4136032729349	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.656	-4.228	2.572	1.871	NA	89.08	0.003292755	0	0.094112426	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.095	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320A	320	L	A	missense	low	0.399493381813167	0.297491055623017	8	0.10517897138669	0.193346385964286	0.605640377662048	1.0373837172982	0.293983016000975	0.405866708264778	0.603587959829984	0.145774654644572	0.189180492250431	0.181660744711252	0.338509761505144	0.453965079512728	0.800675528912092	0.44374474618897	0.493110105976773	0.560401710787141	0.434581552986507	0.384583636310168	0.385428549117993	0.464185412836486	p.Leu320Ala	0	0	NA	NA	NA	NA	NA	NA	NA	5.613	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.259	-3.152	1.893	3.37	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320C	320	L	C	missense	possibly_low	0.51321490157002	0.307639073693805	5	0.137580376262883	0.243562319115299	0.78286748402474	NA	0.310671598819993	0.393224648515432	0.463634457488145	1.05385130971728	NA	NA	0.344692493309249	0.486909776643723	NA	0.451437902007048	0.486909776643723	0.499024886637872	0.773782534035284	NA	NA	0.467290677871837	p.Leu320Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.259	-4.752	3.493	0.768	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320D	320	L	D	missense	low	0.388819180258406	0.124369146553862	7	0.0470071189358377	0.296686920127173	0.480951440389638	NA	0.344605737688635	0.359667732257339	0.579920430846281	0.386494646654506	0.456528508074834	0.170520390292241	0.423996815995001	0.507121119849731	NA	0.467080968928901	0.470451704436579	0.550022279474787	0.524499575866729	0.516352172031297	0.379428427833481	0.507121119849731	p.Leu320Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.259	-4.009	2.75	2.462	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320E	320	L	E	missense	low	0.228658991363171	0.217159292161204	4	0.108579646080602	0.0158467955910855	0.441471187135256	NA	-0.0909453384810962	0.374937139601403	NA	0.353461743895101	NA	NA	0.277182420437275	0.455662248906575	NA	0.266299252947178	0.477940622866868	NA	0.51216053712998	NA	NA	0.433383874946281	p.Leu320Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.259	-3.767	2.508	4.161	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320F	320	L	F	missense	wt-like	0.802115284816981	0.122779587242308	8	0.0434091393651605	0.717034935061387	0.887195634572576	0.613895958270754	0.752705005048714	0.830629732468799	0.990098447625425	0.732265726989397	0.957298265099105	0.754465845517829	0.785563297515826	0.691327387241264	0.599189997142366	0.655207863051208	0.701436177106406	0.729906480902331	0.653658154069028	0.763167909238241	0.693937591825065	0.688717182657462	p.Leu320Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.259	-2.384	1.125	19.225	19.225	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	medium	2.54	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.571428571428571
L320G	320	L	G	missense	low	0.339244371058867	0.168911669870668	7	0.0638426102877757	0.2141151542158	0.464373587901934	0.288112401373429	0.35274723670878	0.337494790600383	0.426706399948516	0.635769854618064	0.0849873624769449	NA	0.248892551685951	0.459576930603719	0.444189830540064	0.47083406295935	0.459576930603719	0.482830030090103	0.617613295529092	0.333229688160909	NA	0.419175343334116	p.Leu320Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.259	-3.732	2.473	2.557	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320H	320	L	H	missense	low	0.110649921925835	0.0499382239020949	2	0.0353116567615834	0.0414403464386917	0.179859497412979	NA	NA	NA	NA	0.075338265164252	NA	0.145961578687419	NA	0.387236055620266	NA	NA	NA	NA	0.408270897074594	NA	0.366201214165938	NA	p.Leu320His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.259	-4.785	3.526	1.196	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320I	320	L	I	missense	possibly_low	0.533193414078245	0.433151125907102	4	0.216575562953551	0.108713110757798	0.957673717398692	0.785406425634233	0.56713137996043	NA	NA	-0.0879800321521645	NA	NA	0.868215882870482	0.62522609763016	0.680790650252543	0.569661545007777	NA	NA	0.347265335084336	NA	NA	0.730229283055024	p.Leu320Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.259	-2.452	1.193	12.263	12.263	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
L320K	320	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu320Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.259	-2.65	1.391	16.226	16.226	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320L	320	L	L	synonymous	wt-like	1.13650056686183	0.128768953993306	7	0.0486700898360295	1.04110894365889	1.23189219006478	1.1684197084482	1.14439616285208	0.976363827525053	1.00437303019187	1.35738370810208	NA	1.20714015527468	1.09742737563887	0.845350309932138	0.863019376626754	0.835770894809119	0.772911822872878	0.736166621086925	0.887163366740392	NA	0.937744984190322	0.845350309932138	p.Leu320=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L320M	320	L	M	missense	wt-like	0.984580042777367	0.112433123976335	2	0.079502224393654	0.828758546274984	1.14040153927975	1.06408226717102	NA	NA	NA	NA	NA	NA	0.905077818383713	0.781060595285859	0.813378072029181	NA	NA	NA	NA	NA	NA	0.748743118542536	p.Leu320Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.259	-2.845	1.586	8.239	8.239	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.74	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
L320N	320	L	N	missense	low	0.256885190093639	0.144668375256663	6	0.0590606168827171	0.141128508098795	0.372641872088483	NA	0.306974533929352	0.275423191137266	0.393890866636371	0.0070179078307554	NA	0.17998326910981	0.37802137191828	0.439433689559205	NA	0.449733617312434	0.429133761805975	0.468438727380547	0.382750659213982	NA	0.384525071842325	0.484030042394066	p.Leu320Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.259	-4.045	2.786	2.457	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320P	320	L	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu320Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.259	-4.094	2.835	1.588	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320Q	320	L	Q	missense	possibly_low	0.401395325920823	0.486428411338053	5	0.217537398787823	-0.0249701409938373	0.827760792835484	0.317371373880647	NA	0.711225687999003	0.931685863591948	-0.348369550675429	NA	NA	0.395063254807948	0.492589294962438	0.458110562624956	NA	0.642874169483462	0.704289552148592	0.25	NA	NA	0.492589294962438	p.Leu320Gln	0	0	NA	NA	NA	NA	NA	NA	NA	5.726	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.259	-4.064	2.805	3.118	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320R	320	L	R	missense	low	0.39533122593485	0.18683479295524	6	0.0762749848231466	0.245835002760144	0.544827449109557	0.251528383399094	0.428057699067641	0.402083596376456	0.503740954323702	0.658787240144971	NA	NA	0.127789482297238	0.498402794050387	0.426784013822338	0.505550918664916	0.491254669435858	0.516613652637501	0.626211159716317	NA	NA	0.358351562041062	p.Leu320Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.259	-3.856	2.597	6.277	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320S	320	L	S	missense	low	0.279471748319076	0.119010825255448	8	0.0420766807863672	0.197002969388808	0.361940527249345	0.289923386231809	0.443518859021469	0.289050677161699	0.389638343038243	0.14637116247392	0.084054567145041	0.337869452385369	0.25534753909506	0.440434425246891	0.445051454611691	0.512678253199128	0.435817395882091	0.466573776602571	0.43480437122524	0.332769938816469	0.469561526982874	0.422417348218078	p.Leu320Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.259	-3.57	2.311	3.123	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L320T	320	L	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu320Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.259	-3.496	2.237	2.363	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320V	320	L	V	missense	possibly_low	0.576309259953073	0.352890512376594	4	0.176445256188297	0.230482912581068	0.922135607325078	NA	0.253990398149199	0.440000009957535	0.53547927242316	1.0757673592824	NA	NA	NA	0.520191704397462	NA	0.425308822417421	0.509850867839602	0.530532540955323	0.781969007579862	NA	NA	NA	p.Leu320Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.259	-2.946	1.687	7.961	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.09	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
L320W	320	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu320Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.259	-5.012	3.753	0.893	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L320X	320	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu320Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	1	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L320Y	320	L	Y	missense	possibly_low	0.575172973780522	0.187807063910661	7	0.0709843979384032	0.436046110356992	0.714299837204051	0.741428487581181	0.264504674509535	0.67420053365745	0.714924111623855	0.459652077208486	0.436472890401769	NA	0.735028041481377	0.609228351748351	0.659866979979039	0.430155726868902	0.624715091368322	0.609228351748351	0.551826643550162	0.506467305799493	NA	0.6633359485059	p.Leu320Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.2	69.8	38.3	0.945	11	-149.2	-111.2	121.6	3.66492146596859	-5.5	0	1	23.19	0	0	0	0	6	23.0933977114672	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.259	-3.79	2.531	4.459	NA	58.56	0.00313482	0	0.089598366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.09	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T321A	321	T	A	missense	wt-like	0.955351976631579	0.130881282735089	7	0.0494684750557397	0.858395547152211	1.05230840611095	NA	0.968868443786566	0.823159590469701	1.07765209713407	0.824333484912192	0.836226607052236	1.1435038303854	1.01371978268088	0.754855570374017	NA	0.754855570374017	0.697772427568958	0.768303268832606	0.688048944357402	0.703494995455917	0.903470880057274	0.803308334015718	p.Thr321Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.118	-2.672	0.554	26.235	26.235	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
T321C	321	T	C	missense	wt-like	0.935582854793894	0.237112084129232	6	0.0968006029940825	0.745857159243732	1.12530855034406	1.14137146658007	NA	1.06159673072491	0.634488467528689	0.96871796131413	0.649605637644616	NA	1.15771686497095	0.778348259066949	0.850150458269462	NA	0.814714510119189	0.573953176062474	0.741982008014709	0.611514616256652	NA	0.875630588804622	p.Thr321Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.118	-5.076	2.958	1.941	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T321D	321	T	D	missense	wt-like	1.00895247149609	0.170406338257553	4	0.0852031691287765	0.841957328635013	1.17594761435717	1.16772032520236	1.06678089330965	0.768165410933982	1.03314325653837	NA	NA	NA	NA	0.77438770498643	0.862686626500697	0.799991561780813	0.670800396801583	0.748783848192047	NA	NA	NA	NA	p.Thr321Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.118	-2.418	0.3	32.978	32.978	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T321E	321	T	E	missense	wt-like	1.21814765152752	0.091423037091698	4	0.045711518545849	1.12855472149903	1.30774058155602	1.17053760103474	1.15732769184835	1.19102940026359	1.35369591296342	NA	NA	NA	NA	0.871111050894948	0.864027020188895	0.841732112044468	0.878195081601001	0.889362709705107	NA	NA	NA	NA	p.Thr321Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.118	-3.389	1.271	7.62	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T321F	321	T	F	missense	wt-like	0.878191994582187	0.155779284932293	8	0.055076294372008	0.770244441211125	0.986139547953249	0.65640329706461	0.927406478229887	0.760935254823984	0.706627297557499	1.07510258504956	1.02806078034155	0.995797480419001	0.875202783171402	0.734740371097178	0.619413990819692	0.735742302038983	0.66725434893437	0.605589771152446	0.781720689257071	0.798044820475784	0.82391721587774	0.733738440155373	p.Thr321Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.118	-4.244	2.126	5.996	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T321G	321	T	G	missense	possibly_wt-like	0.824734456894353	0.440021450773159	6	0.179638005045571	0.472650436750409	1.1768184770383	NA	NA	0.488580884890239	0.0798684924637493	1.08358946672581	1.03052469747125	1.11106196478335	1.15478123503171	0.792075039270543	NA	NA	0.533677477572725	0.330723731213801	0.784890860601688	0.799259217939399	0.885997905591044	0.87415617437167	p.Thr321Gly	0	0	NA	NA	NA	NA	NA	NA	NA	2.587	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.118	-2.697	0.579	25.936	25.936	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.705	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T321H	321	T	H	missense	wt-like	1.17416346617902	0.144250497729272	4	0.0721252488646358	1.03280057602835	1.3155263563297	NA	1.12982397571738	1.00340932415393	1.34562043609195	NA	NA	NA	1.21780012875283	0.857437279330326	NA	0.829053361783505	0.786176353289575	0.885821196877146	NA	NA	NA	0.905807291295225	p.Thr321His	0	0	NA	NA	NA	NA	NA	NA	NA	1.591	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.118	-3.236	1.118	17.043	17.043	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T321I	321	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr321Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.118	-4.035	1.917	3.891	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.7	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
T321K	321	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr321Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.118	-2.823	0.705	12.169	12.169	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.428571428571429
T321L	321	T	L	missense	wt-like	0.982609637215156	0.125905780577623	6	0.0514008196803329	0.881865881865866	1.08335339256445	1.17587448155831	0.919803036938303	0.944043378714862	1.09922727594239	0.85447808797466	NA	0.902231562162408	NA	0.765291704837688	0.866566182625971	0.732237243566126	0.757060179170154	0.777765096750802	0.699309093899839	NA	0.773523230505223	NA	p.Thr321Leu	0	0	NA	NA	NA	NA	NA	NA	NA	2.494	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.118	-3.585	1.467	5.392	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T321M	321	T	M	missense	possibly_wt-like	0.848120981716181	0.392224334381207	7	0.148246863845788	0.557562467757424	1.13867949567494	1.15541732091585	1.06157711623359	0.699787802545689	0.957071037557814	0.03270072714487	1.13445059942532	NA	0.895842268190129	0.7441045814028	0.856833145949751	0.797592708126026	0.637264430398981	0.715422259315119	0.392344163747747	0.850481456794461	NA	0.7441045814028	p.Thr321Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.118	-4.77	2.652	1.637	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T321N	321	T	N	missense	wt-like	1.0038598776131	0.314353474455702	6	0.128334268547916	0.75232933327689	1.2553904219493	NA	0.510276388960748	1.33024960499919	1.35929687208426	0.91588100652121	1.00288769119759	0.904567701915581	NA	0.780209576127676	NA	0.543452351001348	0.946475973820329	0.891819018959785	0.722245406703278	0.785637692314208	0.774781459941145	NA	p.Thr321Asn	0	0	NA	NA	NA	NA	NA	NA	NA	2.814	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.118	-2.303	0.185	28.293	28.293	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.045	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T321P	321	T	P	missense	wt-like	0.932955760949432	0.229420940177538	5	0.102600163539778	0.731863135603549	1.13404838629532	NA	1.20438510603583	0.986708312782264	1.07076903999364	0.763899659983935	NA	NA	0.6390166859515	0.765284693515457	NA	0.863424788029368	0.777985301138862	0.765284693515457	0.665474624678901	NA	NA	0.615114431744384	p.Thr321Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.118	-2.979	0.861	25.412	25.412	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	low	1.425	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.5
T321Q	321	T	Q	missense	wt-like	1.17433217464152	0.0992326438450257	4	0.0496163219225129	1.07708597062805	1.27157837865499	NA	NA	NA	NA	1.15180343945045	1.22129734459139	1.04694123470197	1.27728667982226	0.872374374861411	NA	NA	NA	NA	0.810371359786618	0.893285845700776	0.851462904022045	0.935684295985432	p.Thr321Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.118	-3.047	0.929	10.67	10.67	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T321R	321	T	R	missense	wt-like	0.945026124732251	0.112931240320199	5	0.0505043860278661	0.846039347056325	1.04401290240818	NA	0.908397982121968	0.899000150766608	0.879826761163789	NA	1.14617818902359	NA	0.891727540585298	0.734968617111426	NA	0.726979705237839	0.734968617111426	0.681546662853134	NA	0.856261665426784	NA	0.742037967458331	p.Thr321Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.118	-2.74	0.622	18.867	18.867	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	1.705	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
T321S	321	T	S	missense	possibly_wt-like	0.806351268541068	0.553226099561829	6	0.225853609386107	0.363686328365919	1.24901620871622	NA	1.18011831072311	1.07243209856763	0.910168632490863	0.0458145790235099	1.41912893159599	0.210445058845302	NA	0.757440940122335	NA	0.852238203789668	0.820028742957956	0.694853137286714	0.397242683490231	0.990791632151442	0.400931590529411	NA	p.Thr321Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.118	-2.546	0.428	19.864	19.864	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.245	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
T321T	321	T	T	synonymous	wt-like	0.986833783006355	0.200784766657759	4	0.100392383328879	0.790068327359613	1.1835992386531	0.826889407133774	1.14734837507447	0.800006096187115	NA	NA	NA	NA	1.17309125363006	0.768829546870761	0.700527278782311	0.837131814959212	0.686416739286409	NA	NA	NA	NA	0.883352345635696	p.Thr321=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T321V	321	T	V	missense	possibly_wt-like	0.770416630716784	0.254786703425682	8	0.0900807028742327	0.593861697381234	0.946971564052334	1.092523208035	0.876916038647433	0.711394228793528	0.949563430756699	0.491373192920656	0.31428075727989	0.848891820117063	0.878390369183996	0.71229842295251	0.826909603866538	0.712467059123302	0.642956830731141	0.712129786781717	0.563675680202986	0.446242140452888	0.74479479786124	0.735339399036609	p.Thr321Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.118	-3.661	1.543	6.185	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.4	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T321W	321	T	W	missense	possibly_low	0.596297213130327	0.338025472598827	3	0.195159097597883	0.213792410583138	0.978802015677516	NA	NA	NA	NA	0.331683313835144	0.480117073876887	0.977091251678951	NA	0.527978331911008	NA	NA	NA	NA	0.504025469676398	0.527978331911008	0.813842164672493	NA	p.Thr321Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.118	-5.375	3.257	1.255	NA	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.4	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T321X	321	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr321Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T321Y	321	T	Y	missense	wt-like	1.07761890905298	0.169673246484918	8	0.059988551587711	0.960043508456345	1.19519430964962	1.20739093799689	0.931285567292082	0.93711393965798	0.823480902082243	1.26256004568463	1.27821196750252	1.04478778367872	1.13612012852879	0.851023105701482	0.881560972557105	0.737530496813297	0.753661618722107	0.656836099512315	0.851743141873953	0.921337508994383	0.850303069529012	0.86478366988975	p.Thr321Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.6	70.5	37.5	0.4	33.8	-99.7	-85	167.4	25.7668711656442	-3.1	0	1	24.23	0	0	0	0	6	23.3135788299437	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.118	-3.135	1.017	14.492	14.492	90.32	0.002594863	0	0.074165498	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.05	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K322A	322	K	A	missense	possibly_low	0.578619526443301	0.547847254806235	5	0.245004740606678	0.098419058812634	1.05881999407397	1.00104582314732	0.535067133353699	0.77959565010891	0.925758576282003	-0.348369550675429	NA	NA	NA	0.676406385750002	0.783386812130298	0.554880466949204	0.676406385750002	0.701690131163641	0.25	NA	NA	NA	p.Lys322Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-0.976	-3.049	2.073	3.222	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322C	322	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-0.976	-5.088	4.112	0.413	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322D	322	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-0.976	-3.307	2.331	5.3	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322E	322	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-0.976	-2.224	1.248	17.396	17.396	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	2	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K322F	322	K	F	missense	low	0.320733840865307	0.118891598242808	3	0.0686420962498699	0.18619780439223	0.455269877338384	NA	NA	NA	NA	0.451073952587635	0.218230105974511	NA	0.292897464033776	0.441276725057754	NA	NA	NA	NA	0.548622389514231	0.398901397569338	NA	0.441276725057754	p.Lys322Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-0.976	-4.263	3.287	0.918	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322G	322	K	G	missense	low	0.391922731917862	0.128639525841621	6	0.0525168665109237	0.288991564975554	0.49485389886017	0.258027633616704	0.230332962938091	0.376419569741194	0.431174845268041	0.52746915889117	NA	NA	0.528112221051976	0.481728679025473	0.42987620446607	0.414403142929302	0.478667684379168	0.484789673671778	0.577158888917476	NA	NA	0.559412879739786	p.Lys322Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-0.976	-3.329	2.353	2.09	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322H	322	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-0.976	-4.39	3.414	1.474	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322I	322	K	I	missense	possibly_low	0.532514710446602	0.282801422286729	7	0.106888890540864	0.323016334639066	0.742013086254139	0.366896996022135	0.0660948872667208	0.876256502107989	0.869623487651846	0.533003363640088	NA	0.477311666435384	0.538416070002052	0.564587967854228	0.481673690721789	0.338692154099181	0.723813938624329	0.677072001529119	0.579226123736994	NA	0.544664182159912	0.564587967854228	p.Lys322Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-0.976	-3.982	3.006	1.315	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K322K	322	K	K	synonymous	wt-like	1.20901607592405	0.110117865838072	2	0.0778650896638914	1.05640330452985	1.36162884731826	1.28688116558795	NA	NA	NA	NA	NA	NA	1.13115098626016	0.890834242082141	0.919380556323736	NA	NA	NA	NA	NA	NA	0.862287927840546	p.Lys322=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K322L	322	K	L	missense	possibly_wt-like	0.82587622618392	0.280522898572976	5	0.125453654090891	0.579991582436828	1.07176086993101	NA	0.644710825754653	0.731770597696902	0.878198605758832	NA	NA	1.2877110318906	0.586990069818607	0.652950471033243	NA	0.605424363891056	0.652950471033243	0.680832632790966	NA	NA	0.981139925994869	0.588984164881142	p.Lys322Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-0.976	-3.359	2.383	2.16	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322M	322	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-0.976	-4.481	3.505	0.732	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322N	322	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-0.976	-3.419	2.443	2.383	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K322P	322	K	P	missense	low	0.32939726098902	0.271182585882582	5	0.121276539269526	0.091699611851092	0.567094910126948	NA	0.624575026909335	0.309840107382902	0.442756886567135	-0.108140555278448	NA	0.377954839364176	NA	0.489868995733814	NA	0.596142099499979	0.446013623124618	0.489868995733814	0.339734617072051	NA	0.491151251561026	NA	p.Lys322Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-0.976	-3.626	2.65	1.533	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322Q	322	K	Q	missense	possibly_wt-like	0.773274433984436	0.187423386974826	4	0.0937116934874128	0.58960288981885	0.956945978150022	0.581056840303603	0.76370761729461	1.02906172708252	NA	NA	NA	NA	0.719271551257009	0.657851082016784	0.583565915913536	0.660279882127455	0.79875763747071	NA	NA	NA	NA	0.655422281906114	p.Lys322Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-0.976	-3.384	2.408	3.815	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.66	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K322R	322	K	R	missense	possibly_low	0.688768450981198	0.043821350723589	7	0.0165629137327939	0.656305736585878	0.721231165376518	NA	0.747040273820519	0.719582856181333	0.658600295070383	0.641994174878064	0.635337182585907	0.695782199915923	0.723042174416258	0.646972963196632	NA	0.652596517289939	0.646972963196632	0.58452745519219	0.619938314597427	0.604482084429957	0.662330968033287	0.657316070061396	p.Lys322Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-0.976	-3.059	2.083	2.904	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.315	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K322S	322	K	S	missense	low	0.458721671977408	0.307351431289778	7	0.116167921756073	0.231036729176638	0.686406614778177	NA	0.324208091405839	0.592582874315187	0.802910274545446	-0.15723745472832	0.620256671243894	0.532381408173943	0.495949838885866	0.574324381208359	NA	0.457677997275923	0.584685509373907	0.647814819102466	0.321395067908642	0.597049312238492	0.574324381208359	0.543259385789471	p.Lys322Ser	0	0	NA	NA	NA	NA	NA	NA	NA	2.477	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-0.976	-3.132	2.156	3.185	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322T	322	K	T	missense	possibly_low	0.656082524902737	0.072482347790267	2	0.0512527596388195	0.555628961902363	0.756536087903111	NA	NA	NA	NA	0.707335284541557	NA	0.604829765263918	NA	0.628845139209033	NA	NA	NA	NA	0.644345690755443	NA	0.613344587662623	NA	p.Lys322Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-0.976	-3.393	2.417	2.21	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K322V	322	K	V	missense	possibly_low	0.626162250590873	0.421251119053235	5	0.188389227560178	0.256926149497604	0.995398351684142	NA	0.782362904177924	0.648484177227762	1.11861799429164	-0.0389437294590296	NA	NA	0.620289906716066	0.612102441035102	NA	0.668879655420412	0.612102441035102	0.78626892616797	0.365582249066873	NA	NA	0.605708943260163	p.Lys322Val	0	0	NA	NA	NA	NA	NA	NA	NA	0.015	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-0.976	-3.5	2.524	1.832	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K322W	322	K	W	missense	possibly_low	0.387366305749926	0.33017695636812	4	0.16508847818406	0.0637988342466415	0.71093377725321	NA	0.33679311420482	0.57371954818787	0.69400743906678	NA	-0.0550548784597683	NA	NA	0.519456712806405	NA	0.463479480985869	0.575433944626941	0.600055312761533	NA	0.264206692159111	NA	NA	p.Lys322Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-2.92	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-0.976	-5.294	4.318	0.286	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K322X	322	K	X	nonsense	low	0.17471899726415	0.120167298234567	6	0.049058094073923	0.0785668997290827	0.270871094799217	0.0733283592299364	0.190428115905792	0.254764804307654	0.188594043507518	NA	0.00470739487334611	NA	0.336491265760651	0.387206584610483	0.342000626662443	0.396007680028389	0.419001805117528	0.378405489192578	NA	0.293661884576333	NA	0.463171627270821	p.Lys322Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K322Y	322	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys322Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	71.3	34.1	0.872	127.2	55.9	-51.8	-39	5.65217391304348	-3.4	0	0	26.75	3	15	0	0	8	21.7165530842259	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-0.976	-4.134	3.158	0.939	NA	58.56	0.004126054	0	0.117929481	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.21	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N323A	323	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-2.068	-2.664	0.596	14.807	14.807	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N323C	323	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-2.068	-3.243	1.175	19.428	19.428	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N323D	323	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-2.068	-2.322	0.254	21.756	21.756	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.815	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N323E	323	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-2.068	-2.516	0.448	13.563	13.563	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.02	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N323F	323	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-2.068	-4.133	2.065	3.206	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N323G	323	N	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-2.068	-3.379	1.311	4.006	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N323H	323	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-2.068	-3.157	1.089	30.835	30.835	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
N323I	323	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-2.068	-3.861	1.793	6.739	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.571428571428571
N323K	323	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-2.068	-2.795	0.727	13.819	13.819	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
N323L	323	N	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-2.068	-2.745	0.677	21.99	21.99	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N323M	323	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-2.068	-3.247	1.179	8.32	8.32	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.71	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N323P	323	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-2.068	-3.984	1.916	2.286	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N323Q	323	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-2.068	-3.87	1.802	3.485	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.365	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N323R	323	N	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-2.068	-3.801	1.733	5.346	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.71	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N323S	323	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-2.068	-3.337	1.269	7.953	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.815	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	T	D	B	0.214285714285714
N323T	323	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-2.068	-2.776	0.708	21.174	21.174	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	2	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.125	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N323V	323	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-2.068	-3.566	1.498	6.159	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.365	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N323W	323	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-2.068	-2.892	0.824	22.425	22.425	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.91	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N323X	323	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N323Y	323	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn323Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	24.2	74.9	35.1	0.737	101.7	57.2	-66.5	-23.1	59.8930481283422	-0.8	0	0	29.47	0	0	0	0	6	19.6372533176104	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-2.068	-4.089	2.021	5.055	NA	87.1	0.003105923	0	0.088772439	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.165	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D324A	324	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.528	-3.249	1.721	4.71	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D324C	324	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.528	-5.212	3.684	0.799	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D324E	324	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.528	-1.699	0.171	25.431	25.431	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.68	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
D324F	324	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.528	-4.355	2.827	1.367	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D324G	324	D	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.528	-3.26	1.732	5.212	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.005	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D324H	324	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.528	-4.33	2.802	2.607	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D324I	324	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.528	-4.073	2.545	1.922	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D324K	324	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.528	-3.245	1.717	6.513	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D324L	324	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.528	-3.671	2.143	3.157	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D324M	324	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.528	-4.732	3.204	1.184	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.89	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D324N	324	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.528	-2.322	0.794	25.778	25.778	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D324P	324	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.528	-3.747	2.219	2.241	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D324Q	324	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.528	-2.224	0.696	11.732	11.732	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.8	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D324R	324	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.528	-3.633	2.105	4.245	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D324S	324	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.528	-3.187	1.659	5.736	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D324T	324	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.528	-3.448	1.92	4.076	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D324V	324	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.528	-3.699	2.171	2.678	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D324W	324	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.528	-5.441	3.913	0.418	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D324X	324	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D324Y	324	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp324Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.9	74.6	35.9	0.453	91.3	92.3	-87	-0.9	32.0855614973262	-2.7	0	0	22.58	1	3	0	0	7	18.5262062457482	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.528	-4.25	2.722	1.372	NA	85.61	0.003095311	0	0.08846914	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.695	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
L325A	325	L	A	missense	low	0.349862968290912	0.329055017662699	4	0.16452750883135	0.0273949765153715	0.672330960066453	NA	0.126508443384392	0.351213689965988	0.107099621912202	0.814630117901066	NA	NA	NA	0.416423592657013	NA	0.366541786735922	0.466305398578103	0.342665985002215	0.684424369723461	NA	NA	NA	p.Leu325Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.333	-3.162	1.829	3.994	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
L325C	325	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325Cys	0	0	NA	NA	NA	NA	NA	NA	NA	7.153	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.333	-4.811	3.478	0.885	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325D	325	L	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.333	-3.948	2.615	2.7	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325E	325	L	E	missense	low	0.373725500361352	0.260466173047225	7	0.0984469598325245	0.180773004702143	0.566677996020562	0.678652789734004	0.159115838945247	0.27910437624899	0.45739071457135	0.752148249400482	0.0996796739868002	NA	0.189986859642594	0.43093920810833	0.629999776988328	0.381573247321389	0.43093920810833	0.496286683558814	0.661085028298081	0.340471127256847	NA	0.389590073961125	p.Leu325Glu	0	0	NA	NA	NA	NA	NA	NA	NA	10.818	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.333	-3.675	2.342	4.584	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325F	325	L	F	missense	low	0.377949791002904	0.160322135518233	5	0.0716982386633405	0.2374238254678	0.518475756538009	0.282192726621319	0.189596023928515	0.332942624733547	0.511034845328452	0.573982734402689	NA	NA	NA	0.457344309645373	0.441373388293724	0.395624099630605	0.457344309645373	0.519812399779027	0.594533468868912	NA	NA	NA	p.Leu325Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.333	-3.801	2.468	2.459	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	1	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L325G	325	L	G	missense	low	0.202504279232018	0.180219128564792	8	0.0637170839538474	0.0776210894825625	0.327387468981474	0.488243344222031	0.24530591232483	0.229460498004887	0.316947878640874	-0.110933945966793	0.0370637931526307	0.160091873154852	0.253854880322834	0.413948333196058	0.539407433844658	0.421305420608454	0.406591245783662	0.434695261410084	0.338691179982631	0.309609469634422	0.373811697405662	0.421667663250015	p.Leu325Gly	0	0	NA	NA	NA	NA	NA	NA	NA	9.739	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.333	-3.722	2.389	2.931	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325H	325	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.333	-2.989	1.656	25.564	25.564	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L325I	325	L	I	missense	possibly_wt-like	0.790362657748025	0.213182135408581	2	0.150742533575236	0.494912721002242	1.08581259449381	NA	NA	NA	NA	NA	NA	0.639620124172788	0.941105191323261	0.699460120853074	NA	NA	NA	NA	NA	NA	0.632082445107149	0.766837796599	p.Leu325Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.333	-1.985	0.652	14.89	14.89	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.01	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
L325K	325	L	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.333	-2.657	1.324	16.226	16.226	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L325L	325	L	L	synonymous	possibly_low	0.486220076179078	0.499889782731879	6	0.204079149220641	0.0862322937110458	0.886207858647111	0.715308485015867	0.771650337576538	0.560998007344176	0.0213597430370386	-0.241606043353396	NA	NA	1.08960992745425	0.608317164840684	0.647439696085911	0.663941342504944	0.569194633595458	0.305064628978648	0.289880208594221	NA	NA	0.84142401177098	p.Leu325=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L325M	325	L	M	missense	low	0.410122205058788	0.0966777633377162	6	0.0394685316084926	0.332765304583462	0.487479105534114	NA	0.372802235452764	0.570715966967153	0.480907956386535	0.314083218810963	0.345116789304574	0.377107063430737	NA	0.494072906729888	NA	0.480079079863542	0.573960830821417	0.506600206201791	0.497451168415151	0.461440378505312	0.490694645044626	NA	p.Leu325Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.333	-4.09	2.757	2.025	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
L325N	325	L	N	missense	low	0.369651229203428	0.147140380307218	4	0.0735701901536088	0.225456306166591	0.513846152240264	NA	0.278986143214841	0.556376113590233	NA	NA	0.228748320334875	NA	0.414494339673761	0.469589979903172	NA	0.436831440225317	0.566927814423187	NA	NA	0.404085538174953	NA	0.502348519581027	p.Leu325Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.333	-3.908	2.575	3.939	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325P	325	L	P	missense	low	0.210270328182054	0.160762754701733	7	0.0607626098603523	0.0911778012491047	0.329362855115003	NA	0.346329877608903	0.42380819592089	0.339115784419795	0.108830290529668	0.0352861581318733	0.0285117086440781	0.190010282019168	0.420781435472204	NA	0.46787576841563	0.501909552775662	0.444417030654751	0.420781435472204	0.308733321879933	0.302943490165019	0.389601837804248	p.Leu325Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.333	-4.072	2.739	1.63	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Mar 6, 2013)	criteria provided, single submitter	0	0	1	0	0	2	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L325Q	325	L	Q	missense	possibly_low	0.347915507691866	0.439656141577951	5	0.196620203858714	-0.0374530105041366	0.73328402588787	NA	NA	0.614970707931235	NA	-0.140250556468524	0.965993512022553	0.112326476863331	0.186537398110737	0.387857588609172	NA	NA	0.595665677497239	NA	0.327740316982617	0.767453558979472	0.348085570554363	0.387857588609172	p.Leu325Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.333	-4.015	2.682	4.231	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325R	325	L	R	missense	low	0.234710831834181	0.0723454483748909	8	0.0255779785669333	0.184578915045655	0.284842748622708	0.203166635600251	0.252781137000316	0.233879038013509	0.251317556146218	0.369876415486235	0.247889656226661	0.108160390758981	0.210615825441279	0.407335655970492	0.403774629808639	0.424751373379118	0.408758329610815	0.405912982330169	0.518292037897237	0.413519779885816	0.345841744104357	0.399950931950725	p.Leu325Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.333	-2.766	1.433	30.221	30.221	87.84	0.003071863	0	0.087798955	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 6, 2015)	criteria provided, single submitter	0	0	1	0	0	5	0	2	0	2	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
L325S	325	L	S	missense	low	0.254802772497559	0.372834463107457	7	0.140918181368088	-0.0213917877507778	0.530997332745895	NA	0.451822507471746	0.640836481691851	0.688251404891805	-0.343746056723769	-0.0477789973630178	0.227489607186783	0.166744460327514	0.410111671650895	NA	0.516506095387964	0.608351609928328	0.59753099510286	0.25172704988672	0.267792775247267	0.410111671650895	0.377916624065906	p.Leu325Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.333	-3.578	2.245	3.857	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325T	325	L	T	missense	possibly_low	0.411953527649451	0.384663589702796	6	0.157038252899859	0.104164207770635	0.719742847528268	NA	0.163286067340774	0.266889836449652	0.361706587677619	1.18296962398729	0.191496393028156	NA	0.305372657413213	0.436245461840153	NA	0.383495652428622	0.424948556987459	0.454324262240564	0.82201310865373	0.38572508055622	NA	0.447542366692846	p.Leu325Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.333	-3.505	2.172	3.03	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
L325V	325	L	V	missense	possibly_low	0.595291481431284	0.176838451214841	8	0.0625218340142703	0.472750938515923	0.717832024346645	0.924146006804247	0.453607126863145	0.648070344056929	0.564152954493368	0.774089541668859	0.43695431981743	0.523116358910479	0.438195198835818	0.556220857654776	0.746799685209648	0.517328774893042	0.611899475537471	0.543107428419279	0.669280930947198	0.506704589210627	0.569334286890273	0.514252230043585	p.Leu325Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.333	-2.943	1.61	9.667	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	medium	2.61	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
L325W	325	L	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.333	-5.252	3.919	0.452	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L325X	325	L	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu325Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L325Y	325	L	Y	missense	possibly_low	0.565113476409337	0.39221054461479	8	0.138667367874993	0.293330429543383	0.83689652327529	0.0744583321745094	0.774822319583458	0.699574044985329	0.923887567301355	1.04991107467662	-0.0353265866459742	0.666886868492718	0.366694190706672	0.641963862960297	0.342538241256417	0.665403572827076	0.63715959247716	0.700869597291567	0.772310707197883	0.273930228414156	0.646768133443434	0.478340987639639	p.Leu325Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	28.8	73.5	32.3	0.829	76.5	-126.4	-103.5	133.5	0	-4.3	0	0	22.53	0	0	0	0	8	17.1885856852738	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.333	-3.95	2.617	4.191	NA	87.84	0.003071863	0	0.087798955	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.16	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326A	326	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.004	-2.37	1.366	16.963	16.963	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D326C	326	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.004	-4.994	3.99	1.255	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326E	326	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.004	-2.218	1.214	21.45	21.45	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.935	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D326F	326	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.004	-4.26	3.256	1.291	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326G	326	D	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.004	-3.127	2.123	4.589	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D326H	326	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.004	-4.448	3.444	1.817	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D326I	326	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.004	-3.94	2.936	2.516	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326K	326	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.004	-3.386	2.382	5.494	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326L	326	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.004	-3.663	2.659	3.487	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326M	326	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.004	-4.83	3.826	1.058	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326N	326	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Asn	1	0	yes	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.004	-3.316	2.312	2.938	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D326P	326	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.004	-3.655	2.651	1.89	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326Q	326	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.004	-3.628	2.624	4.705	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326R	326	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.004	-3.833	2.829	3.581	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326S	326	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.004	-3.129	2.125	4.934	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D326T	326	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.004	-3.389	2.385	2.934	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326V	326	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.004	-3.609	2.605	3.999	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D326W	326	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.004	-5.485	4.481	0.352	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D326X	326	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D326Y	326	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp326Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	29.9	75.9	29.5	0.717	97.5	8.3	-45.2	-48.1	5.3475935828877	-2.4	0	0	31.06	1	156	0	0	9	13.6802652700889	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.004	-4.325	3.321	1.157	NA	72.21	0.003244991	0	0.092747234	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K327A	327	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.472	-3.189	1.717	2.557	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K327C	327	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.472	-5.134	3.662	0.575	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K327D	327	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.472	-2.05	0.578	17.916	17.916	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.03	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K327E	327	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.472	-3.011	1.539	4.536	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.005	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K327F	327	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.472	-4.339	2.867	0.984	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K327G	327	K	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.472	-3.3	1.828	3.75	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K327H	327	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.472	-4.386	2.914	1.876	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K327I	327	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.472	-4.057	2.585	1.304	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.655	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K327L	327	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.472	-3.506	2.034	2.408	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K327M	327	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.472	-4.599	3.127	0.949	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K327N	327	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.472	-2.553	1.081	18.547	18.547	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	1.965	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.714285714285714
K327P	327	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.472	-3.755	2.283	1.128	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K327Q	327	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.472	-2.66	1.188	9.396	9.396	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K327R	327	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.472	-2.303	0.831	17.672	17.672	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.31	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K327S	327	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.472	-3.213	1.741	4.127	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.455	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K327T	327	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.472	-3.443	1.971	2.933	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.655	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K327V	327	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.472	-3.674	2.202	1.576	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K327W	327	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.472	-5.406	3.934	0.291	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K327X	327	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K327Y	327	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys327Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	27.6	75.1	26.6	0.752	123.8	61.9	-105.6	-32.3	45.2173913043478	-2	0	0	27.05	1	58	0	0	6	14.7687818678454	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.472	-4.225	2.753	0.922	NA	58.56	0.002563565	0	0.073270951	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.005	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A328C	328	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.01	-4.505	3.495	0.801	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A328D	328	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.01	-3.594	2.584	2.462	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A328E	328	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.01	-3.34	2.33	4.161	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A328F	328	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.01	-4.093	3.083	0.955	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A328G	328	A	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.01	-2.956	1.946	2.943	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A328H	328	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.01	-4.617	3.607	1.196	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A328I	328	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.01	-3.635	2.625	1.576	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
A328K	328	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.01	-2.452	1.442	16.226	16.226	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A328L	328	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.01	-3.186	2.176	2.481	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A328M	328	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.01	-4.48	3.47	0.915	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A328N	328	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.01	-3.718	2.708	2.457	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A328P	328	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.01	-3.655	2.645	1.588	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.215	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A328Q	328	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.01	-3.799	2.789	3.118	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
A328R	328	A	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.01	-3.591	2.581	6.277	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A328S	328	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.01	-2.3	1.29	9.659	9.659	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.84	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
A328T	328	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.01	-3.19	2.18	3.607	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
A328V	328	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.01	-3.176	2.166	1.95	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.635	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
A328W	328	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.01	-5.322	4.312	0.274	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A328X	328	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A328Y	328	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala328Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	25.1	72.8	28.2	0.802	87.6	71.4	-62.2	-34.7	1.65289256198347	-3.1	0	0	16.78	0	0	0	0	8	18.2473811233284	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.01	-4.162	3.152	1.006	NA	42.43	0.002677917	0	0.076539338	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.185	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N329A	329	N	A	missense	possibly_low	0.690134143937248	0.141684429581743	4	0.0708422147908714	0.55128595436209	0.828982333512407	NA	NA	0.87675271162565	0.576067614090827	0.584023067119367	NA	NA	0.723693182913149	0.627963475377257	NA	NA	0.724057305804099	0.548332620748696	0.598283912940488	NA	NA	0.657643037814027	p.Asn329Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.421	-3.326	1.905	2.367	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329C	329	N	C	missense	possibly_low	0.566371070169384	0.384100082696859	5	0.171774779014693	0.229698689848259	0.90304345049051	NA	0.790600383697292	0.885045932931305	NA	0.064896625405835	0.850585877307497	0.240726531504992	NA	0.672676994845693	NA	0.672676994845693	0.728124736614145	NA	0.404370549642439	0.710572287612828	0.417240991630844	NA	p.Asn329Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.421	-5.082	3.661	0.489	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.27	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N329D	329	N	D	missense	possibly_wt-like	0.734009454583471	0.375079214366318	7	0.14176661759468	0.456151989887835	1.01186691927911	NA	0.641329041236541	0.757413400830596	1.00885320282178	1.34000093903237	0.129604090353391	0.578268478521588	0.68259702928803	0.63700257450705	NA	0.603865418142148	0.665527046971329	0.738131407698644	0.880670244944063	0.355220054847635	0.599038854116595	0.63700257450705	p.Asn329Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.421	-2.404	0.983	23.232	23.232	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N329E	329	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn329Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.421	-3.215	1.794	5.368	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329F	329	N	F	missense	possibly_wt-like	0.732664390873878	0.123111653512822	5	0.0550572052154142	0.624754251562235	0.84057453018552	NA	0.602237473025365	0.634009714370475	0.891166196806279	NA	0.823938278674154	NA	0.711970291493115	0.651755238376296	NA	0.585844863090649	0.605003405085773	0.686519589830561	NA	0.69743841399281	NA	0.651755238376296	p.Asn329Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.421	-3.915	2.494	5.996	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329G	329	N	G	missense	low	0.559515708035438	0.12975334176341	8	0.0458747339212613	0.469602881749408	0.649428534321468	0.652655953766886	0.549318518241758	0.566791178047575	0.757999089837321	0.440896091087371	0.34782678033495	0.510050033433636	0.650588019534009	0.567166379375392	0.617631092870529	0.561450115538077	0.572035908431666	0.628118949831305	0.5448205732396	0.462776059074285	0.562296850319119	0.6209261115527	p.Asn329Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.421	-3.134	1.713	2.754	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N329H	329	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn329His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.421	-1.997	0.576	15.989	15.989	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
N329I	329	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn329Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.421	-3.97	2.549	1.955	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N329K	329	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn329Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.421	-3.386	1.965	2.67	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N329L	329	N	L	missense	low	0.484039774448128	0.185148727750316	8	0.0654599604601552	0.355740609516807	0.612338939379448	0.880400933930023	0.42209325510698	0.548422922592825	0.494318572476385	0.292885706678501	0.311856740023647	0.399781714760212	0.522558350016449	0.507694257496624	0.725986806720291	0.502801410378013	0.563027152315089	0.512481452556524	0.489533095782231	0.445047408547238	0.502907062436724	0.556623458803554	p.Asn329Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.421	-3.565	2.144	3.125	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329M	329	N	M	missense	possibly_low	0.639162208489545	0.215959682827561	5	0.0965801062403441	0.449868678635419	0.828455738343672	NA	0.453868451479952	0.722004972110895	0.953493863066531	0.643009268324984	0.423434487465364	NA	NA	0.620317490398421	NA	0.517449241143412	0.648160895918345	0.713853483928802	0.620317490398421	0.500041033071138	NA	NA	p.Asn329Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.421	-4.722	3.301	0.808	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N329P	329	N	P	missense	low	0.533661019582005	0.0554264701520237	6	0.02262776168601	0.48931142162667	0.578010617537339	0.565318083187992	0.611318985478093	0.485607407189401	0.533429316315604	NA	0.548731370173589	NA	0.457560955147349	0.547007786405371	0.576077784841894	0.590031287493507	0.532219128112651	0.529633529544948	NA	0.56179644469809	NA	0.523978643522722	p.Asn329Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.421	-3.897	2.476	1.351	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329Q	329	N	Q	missense	possibly_wt-like	0.725202702463654	0.0424671961480363	3	0.0245184471277974	0.677147429136322	0.773257975790987	NA	0.743946286396426	0.755073378496773	NA	NA	NA	NA	0.676588442497764	0.651170241157876	NA	0.651170241157876	0.664379377255787	NA	NA	NA	NA	0.63398477346653	p.Asn329Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.421	-3.721	2.3	1.807	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329R	329	N	R	missense	possibly_low	0.702997690627126	0.196886224819444	6	0.0803784646984216	0.545458794685595	0.860536586568656	0.699827995668808	1.0077246648651	0.671576911973893	0.583605033913304	0.43481935438856	NA	NA	0.82043218295309	0.631751386203755	0.640074442754124	0.772767634358158	0.623428329653386	0.551638167828565	0.542550682214105	NA	NA	0.706230012616885	p.Asn329Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.421	-3.593	2.172	2.138	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329S	329	N	S	missense	possibly_wt-like	0.749898592594435	0.0851026666767562	5	0.0380590695511466	0.675304186989083	0.824492998199787	NA	0.755881029038643	0.836820881329237	0.608136226553292	0.780978680438009	NA	NA	0.767676145612994	0.671854284877203	NA	0.656671956659483	0.704472641309689	0.562396360168466	0.671854284877203	NA	NA	0.679733395369616	p.Asn329Ser	1	0	NA	NA	NA	NA	NA	NA	NA	-1.103	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.421	-3.162	1.741	3.061	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.62	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
N329T	329	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn329Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.421	-3.405	1.984	2.071	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N329V	329	N	V	missense	possibly_low	0.70605846385443	0.179847238796958	8	0.0635856010655026	0.581432975830714	0.830683951878147	0.966643334385862	0.569198685356809	0.672098247285045	0.701474997188824	0.614792353942109	0.413504422975265	0.848452946365136	0.862302723336393	0.616730712669065	0.767018915787265	0.57061453800367	0.623684019840443	0.603330221885005	0.609777405497688	0.495146775474193	0.74455842335814	0.727259410168499	p.Asn329Val	0	0	NA	NA	NA	NA	NA	NA	NA	-3.166	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.421	-3.714	2.293	2.191	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.415	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N329W	329	N	W	missense	possibly_low	0.623208682831351	0.342738046221086	7	0.129542805020165	0.369309450535533	0.877107915127169	1.11798314103601	0.835464669013175	0.704621604523659	0.294132173809688	0.355749136402594	0.203145777199926	NA	0.851364277834405	0.639635180481515	0.839022842160154	0.693358675330179	0.639635180481515	0.424689398892653	0.513014964758145	0.391466743869612	NA	0.721765597168902	p.Asn329Trp	0	0	NA	NA	NA	NA	NA	NA	NA	-5.245	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.421	-5.171	3.75	1.255	NA	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.965	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N329X	329	N	X	nonsense	low	0.181667757757237	0.117054344616076	5	0.0523482943246463	0.0790669862288277	0.284268529285646	0.323498083068509	0.259660361669517	0.153337323369144	0.154736078671019	NA	NA	NA	0.0171069420079954	0.369256447342821	0.461025506994422	0.427922580177303	0.369256447342821	0.363557026531414	NA	NA	NA	0.302761471240771	p.Asn329Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N329Y	329	N	Y	missense	possibly_low	0.653121220456322	0.10286584666739	2	0.0727371377310072	0.510559050165019	0.795683390747626	0.725858358187329	NA	NA	NA	NA	0.580384082725315	NA	NA	0.614928140148287	0.652459078017839	NA	NA	NA	NA	0.577397202278734	NA	NA	p.Asn329Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	23.9	75.5	30.7	0.767	92.3	62.1	-56.4	-22.5	8.55614973262032	-2.8	0	0	24.63	2	4	0	0	8	17.5364459871435	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.421	-2.629	1.208	14.492	14.492	58.56	0.00220847	0	0.063121762	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.62	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K330A	330	K	A	missense	possibly_low	0.667039794948328	0.147153049567935	8	0.0520264596108835	0.565069807867869	0.769009782028788	0.597881563816753	0.69914310161014	0.808309277207725	0.889425943850957	0.567074956726551	0.476993669875011	0.770342800923507	0.527147045575983	0.61123493979566	0.591570724297397	0.630516726989238	0.690489054863179	0.685756399214915	0.591953152602082	0.526438891378698	0.702488815105744	0.558928122232337	p.Lys330Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-0.881	-3.016	2.135	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330C	330	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys330Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-0.881	-5.026	4.145	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330D	330	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys330Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-0.881	-3.407	2.526	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330E	330	K	E	missense	possibly_low	0.507069033498388	0.414608426596645	3	0.23937428670386	0.0379040527338571	0.976234014262919	0.696171492514238	NA	NA	0.0316236685662422	NA	NA	NA	0.793411939414683	0.638334764412044	0.638334764412044	NA	NA	0.30956588933831	NA	NA	NA	0.692659147800982	p.Lys330Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-0.881	-2.929	2.048	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K330F	330	K	F	missense	low	0.502102407960037	0.0484249106779308	2	0.0342415827187177	0.434990139057701	0.569214676862372	NA	0.467860825241319	0.536343990678754	NA	NA	NA	NA	NA	0.540501250188691	NA	0.523899489961923	0.557103010415459	NA	NA	NA	NA	NA	p.Lys330Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-0.881	-4.231	3.35	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330G	330	K	G	missense	low	0.558225431124464	0.147174557368098	8	0.0520340637665553	0.456240540172755	0.660210322076173	0.640787033094336	0.284246177960299	0.750731037072348	0.441674569736427	0.616953544676625	0.480006879478473	0.640289010116158	0.611115196861045	0.605842827525994	0.611984139110323	0.439256227718908	0.662249665211879	0.489394344019633	0.610584691989733	0.527924020101441	0.632442702656844	0.601100963062255	p.Lys330Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-0.881	-3.297	2.416	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330H	330	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys330His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-0.881	-4.394	3.513	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330I	330	K	I	missense	possibly_low	0.610627120639369	0.249587755716415	5	0.111619037626703	0.391857826902011	0.829396414376728	0.5139197247053	0.622215628671389	0.821590823530661	0.853699349208867	NA	NA	NA	0.241710077080629	0.595054456619917	0.551623652767902	0.595054456619917	0.697003021960876	0.670088446072564	NA	NA	NA	0.415567959419388	p.Lys330Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-0.881	-3.949	3.068	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K330K	330	K	K	synonymous	wt-like	1.11751923476602	0.134260820345767	6	0.0548117503824353	1.01009017808685	1.2249482914452	NA	1.13635349005818	1.18718494159113	1.15943355471423	1.2625562211605	0.86981050812515	1.08977669294695	NA	0.841902535637644	NA	0.832063358005767	0.876309557378749	0.804168653096504	0.851741713269521	0.720047583117864	0.874533798814126	NA	p.Lys330=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K330L	330	K	L	missense	wt-like	0.828297840704134	0.140483340430645	7	0.0530977117324446	0.724228238047052	0.932367443361215	0.599306669341547	0.653283538759198	0.895285482051499	0.910130759950971	0.914316034042938	0.947914480005567	NA	0.877847920777215	0.721660830283458	0.592248756042992	0.609376240311172	0.733146748693342	0.694836528225975	0.721660830283458	0.758542897836962	NA	0.735066955378299	p.Lys330Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-0.881	-3.297	2.416	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330M	330	K	M	missense	possibly_low	0.677229867411643	0.14335545327933	6	0.0585246187299586	0.562523722491986	0.7919360123313	NA	0.917554246518484	0.683299405541056	0.687784649215457	0.54434308816572	NA	0.713929105401622	0.51646870962752	0.613251977084868	NA	0.731200589028741	0.629177655488105	0.59732629868163	0.583461939802114	NA	0.672104771429251	0.553564948750595	p.Lys330Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-0.881	-4.419	3.538	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330N	330	K	N	missense	possibly_wt-like	0.748767621870416	0.149880428976609	6	0.061188428903691	0.628840504948592	0.86869473879224	NA	0.64639394779058	0.807833664385898	1.02135546386302	0.711389347926014	0.698844389015129	0.606788918241856	NA	0.640821544440588	NA	0.606200254823417	0.690255789383596	0.743614293546846	0.645860036785109	0.635783052096066	0.614399774512197	NA	p.Lys330Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-0.881	-3.387	2.506	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K330P	330	K	P	missense	low	0.46927932467874	0.122728823621363	8	0.0433911917148567	0.384234151671348	0.554324497686132	0.490269344239538	0.437047675365781	0.641769282736238	0.626834992297751	0.396085318516922	0.385109379780657	0.279226945052593	0.497891659440439	0.534226705839917	0.540371357080197	0.509695146441023	0.608809104497416	0.570596732704359	0.528082054599637	0.481151634152668	0.437977059991044	0.544234661389981	p.Lys330Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-0.881	-3.593	2.712	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330Q	330	K	Q	missense	possibly_low	0.541264581429922	0.167428019481331	3	0.0966646121174326	0.35180542310022	0.730723739759624	NA	0.630707382923078	0.348110938049767	0.644975423316921	NA	NA	NA	NA	0.578552246685968	NA	0.598969012417467	0.464783646260779	0.578552246685968	NA	NA	NA	NA	p.Lys330Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-0.881	-3.388	2.507	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K330R	330	K	R	missense	wt-like	0.865930947108417	0.0775379761978846	8	0.0274138143845026	0.812200858235926	0.919661035980908	0.900503974769212	0.826956201299604	0.78849957042794	0.859148563471778	0.998932969855499	0.759305332692417	0.931209007942382	0.862891956408505	0.708495883121025	0.735551361509253	0.689436414907982	0.680773335394903	0.672478207385928	0.753268456666788	0.665582600045233	0.789130291345092	0.727555351334068	p.Lys330Arg	1	0	NA	0.548698212934167	-0.640429638825197	0.399364605162215	0.698031820706119	NA	NA	0.245	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-0.881	-2.972	2.091	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K330S	330	K	S	missense	possibly_low	0.579165994177015	0.87011124361177	2	0.615261560744542	-0.626724505954191	1.78505649430822	NA	NA	NA	NA	1.19442755492156	NA	NA	-0.0360955665675279	0.551166846983479	NA	NA	NA	NA	0.82629307928394	NA	NA	0.276040614683017	p.Lys330Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-0.881	-3.099	2.218	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330T	330	K	T	missense	wt-like	0.786965201420476	0.0694495665861109	7	0.0262494688354387	0.735517187889709	0.838413214951242	0.795165003146304	0.802062913245266	0.820608625922804	0.861150577912148	0.706013120540271	NA	0.677625607517535	0.846130561659002	0.677961028057992	0.685433552290257	0.677961028057992	0.696521300725603	0.673356193904271	0.643851812486645	NA	0.652551947330152	0.719136973389096	p.Lys330Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-0.881	-3.36	2.479	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.29	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K330V	330	K	V	missense	low	0.557982260052656	0.137073858294532	7	0.0518090486136341	0.456438390696649	0.659526129408664	NA	0.714455070172619	0.589130774039007	0.66111203082036	0.358046783283744	0.45568124090849	0.449400673322627	0.678049247821747	0.582992418293228	NA	0.637575286802863	0.582992418293228	0.585628980776446	0.513873222782769	0.515934577183887	0.529631505680433	0.634718460102106	p.Lys330Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-0.881	-3.467	2.586	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K330W	330	K	W	missense	low	0.45145133856741	0.259769931822175	7	0.0981838053848113	0.25901461614809	0.64388806098673	0.412927417161475	0.715998120438544	0.575276528199347	0.660850104107197	0.254228721258385	-0.0209414146316415	NA	0.561819893438567	0.576197569307375	0.503573884253104	0.638286607006599	0.576197569307375	0.585514112412705	0.475093249426043	0.281020286840735	NA	0.576342492700785	p.Lys330Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-0.881	-5.261	4.38	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K330X	330	K	X	nonsense	low	0.214584236238196	0.339002216384877	5	0.151606400071936	-0.0825588477285681	0.51172732020496	NA	0.0214604195694243	0.0258074107843944	0.151592312001264	0.813742499677578	NA	NA	0.0603185391583204	0.324464411947902	NA	0.318116415669134	0.30670908769429	0.362178322813199	0.684092810740503	NA	NA	0.324464411947902	p.Lys330Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	2	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K330Y	330	K	Y	missense	possibly_low	0.625206408037243	0.207360000771727	5	0.0927342115079982	0.443450693346847	0.806962122727639	0.555790876576866	0.405245573725204	0.617126694218793	NA	NA	0.966918972630464	0.580949923034888	NA	0.596723086280732	0.571544963645996	0.495034912800062	0.596723086280732	NA	NA	0.767909693238767	0.600483062414855	NA	p.Lys330Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.3	77.1	27.7	0.479	74.4	94.9	-83.3	-3.4	53.0434782608696	-3.4	0	0	29.62	0	0	0	0	6	16.8549072337999	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-0.881	-4.101	3.22	NA	NA	NA	0.002619985	0	0.074883542	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.29	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331A	331	D	A	missense	low	0.448733936733307	0.190429034572344	5	0.0851624532386839	0.28181859555041	0.615649277916203	NA	0.210472115998232	0.606248152580664	0.528062812651737	NA	0.280358457917029	NA	0.618528144518871	0.527280041092269	NA	0.405247626739322	0.5913876787477	0.527280041092269	NA	0.429522765515489	NA	0.604824101619786	p.Asp331Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-0.81	-3.241	2.431	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D331C	331	D	C	missense	low	0.437496305396576	0.10121895692037	4	0.0506094784601849	0.338303550338258	0.536689060454894	NA	0.346972925407081	0.440647576856225	0.577915177797674	NA	NA	NA	0.384449541525325	0.498713523354321	NA	0.468172202628379	0.510168468619591	0.549142872659812	NA	NA	NA	0.48725857808905	p.Asp331Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-0.81	-5.026	4.216	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331D	331	D	D	synonymous	possibly_wt-like	0.815817903224768	0.342060760494283	8	0.120936741661667	0.578786245160275	1.05284956128926	0.376376806191918	0.556168039812981	1.00624289148037	1.07840238720045	1.18467525802063	0.886816222465009	1.1019643619207	0.335897258706094	0.748530772493605	0.486183961803818	0.564607629707983	0.787566083362019	0.768632309697569	0.822650227485256	0.728429235289642	0.881097996798096	0.462873288381846	p.Asp331=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D331E	331	D	E	missense	low	0.504845869254376	0.182107832734705	5	0.0814410986459923	0.345224249046858	0.664467489461895	NA	0.443355681444615	0.692130038625366	0.670226722861045	NA	0.249589794748161	NA	0.468927108592695	0.52968727200582	NA	0.512603031082405	0.63350866122828	0.589626243018512	NA	0.414357731732252	NA	0.52968727200582	p.Asp331Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-0.81	-2.704	1.894	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.83	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D331F	331	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-0.81	-4.231	3.421	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331G	331	D	G	missense	low	0.433577992696352	0.0652379288283949	8	0.0230650909325617	0.38837124516839	0.478784740224314	0.462851786864626	0.440742134449356	0.493490161446364	0.483429056663069	0.383582125750479	0.351958083515043	0.344001422304078	0.5085691705778	0.517404934518886	0.527326727076728	0.511398229902434	0.536085244347959	0.507705838613601	0.523411639135339	0.464812265585795	0.47286416546648	0.54959742061195	p.Asp331Gly	1	0	yes	NA	NA	NA	NA	NA	NA	6.548	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-0.81	-3.072	2.262	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D331H	331	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-0.81	-4.394	3.584	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D331I	331	D	I	missense	low	0.427978108126211	0.0771986439167009	5	0.0345242831137088	0.360311756631277	0.495644459621144	0.502072710380862	0.47912124498822	0.454422371245326	0.310125929888959	NA	NA	NA	0.394148284127685	0.516924350445881	0.545987121533741	0.529090353957346	0.516924350445881	0.431703485270899	NA	NA	NA	0.492129752716095	p.Asp331Ile	0	0	NA	NA	NA	NA	NA	NA	NA	0.301	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-0.81	-3.949	3.139	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331K	331	D	K	missense	possibly_wt-like	0.756745183132822	0.238231424239775	6	0.0972575716806596	0.566123845414907	0.947366520850738	0.744540286010658	0.441564494744487	0.651579529735316	0.650197434657774	0.935308042719367	1.11728131092933	NA	NA	0.637484032448717	0.661347500603209	0.511777324158528	0.613620564294226	0.580842367807697	0.729502139601843	0.842019183388341	NA	NA	p.Asp331Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-0.81	-3.396	2.586	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.485	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D331L	331	D	L	missense	low	0.331813980369354	0.190215845232506	8	0.0672514570265179	0.200003546689536	0.463624414049172	0.421775665671848	0.673290355400512	0.266092590697358	0.214936408420008	0.0514204344221586	0.432943165821643	0.19872195172601	0.395331270795293	0.458640725658239	0.507783673127374	0.618599046076917	0.42455754584516	0.389957973923976	0.399336682537797	0.504727600950785	0.39461760249084	0.492723905471318	p.Asp331Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-0.81	-3.747	2.937	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331M	331	D	M	missense	possibly_low	0.503989479132723	0.334537113799	3	0.193145092705773	0.125432053638758	0.882546904626688	NA	0.164732873016893	0.833598396372611	NA	NA	NA	NA	0.513637168008664	0.552142812474308	NA	0.384162605496212	0.702892165627875	NA	NA	NA	NA	0.552142812474308	p.Asp331Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-0.81	-4.869	4.059	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331N	331	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-0.81	-3.162	2.352	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
D331P	331	D	P	missense	low	-0.0388265460981176	0.300134430761865	2	0.212227091259279	-0.45478400151	0.377130909313764	NA	NA	NA	NA	-0.251053637357397	NA	NA	0.173400545161161	0.333805402297165	NA	NA	NA	NA	0.286351174853726	NA	NA	0.381259629740604	p.Asp331Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-0.81	-3.593	2.783	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331Q	331	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-0.81	-3.613	2.803	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.28	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331R	331	D	R	missense	possibly_low	0.67006833458036	0.282985887022944	4	0.141492943511472	0.392747261231314	0.947389407929406	NA	0.356771183691822	0.639511050566846	0.639466235387568	NA	NA	NA	1.04452486867521	0.591918866399084	NA	0.472689034797279	0.607701548969414	0.576136183828753	NA	NA	NA	0.818780128601026	p.Asp331Arg	0	0	NA	NA	NA	NA	NA	NA	NA	6.773	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-0.81	-3.872	3.062	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331S	331	D	S	missense	low	0.419452292820452	0.198730535586147	8	0.0702618546708995	0.281741588178501	0.557162997462402	0.535661119586272	0.285209680633135	0.564754948720615	0.782193095869839	0.333237536307757	0.302564323056703	0.153557245045737	0.398440393343556	0.499445743396254	0.561967697939523	0.43970038623576	0.57103723474438	0.638729268464827	0.504606030562457	0.440467430000291	0.370292189881111	0.49428545623005	p.Asp331Ser	0	0	NA	NA	NA	NA	NA	NA	NA	4.1	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-0.81	-3.099	2.289	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D331T	331	D	T	missense	low	0.12970658186651	0.2836061598457	4	0.14180307992285	-0.148222347679131	0.407635511412151	NA	0.0138847307910003	0.502980820253123	NA	-0.165465004653365	NA	0.16742578107528	NA	0.348041729269328	NA	0.314624150637781	0.540739961328913	NA	0.318321766783001	NA	0.377761691755655	NA	p.Asp331Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-0.81	-3.36	2.55	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
D331V	331	D	V	missense	low	0.456352242861818	0.12687889752719	8	0.0448584644154747	0.368431268205716	0.54427321751792	0.636294565035425	0.325806136249775	0.456815634882254	0.534948817512415	0.307429363618037	0.610886787145754	0.357360708639183	0.421275929811701	0.511926346270287	0.609846728296166	0.458414669054587	0.518098132489629	0.530299909136675	0.494965701801084	0.592431152258208	0.480059388820269	0.505754560050944	p.Asp331Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-0.81	-3.692	2.882	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
D331W	331	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-0.81	-5.486	4.676	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
D331X	331	D	X	nonsense	low	0.0702751304168732	0.0764249794267047	3	0.0441239824448196	-0.0162062860294507	0.156756546863197	NA	-0.00896259270607252	0.0762515350809853	0.143536448875707	NA	NA	NA	NA	0.331449532665875	NA	0.304091919016009	0.331449532665875	0.358645411623737	NA	NA	NA	NA	p.Asp331Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D331Y	331	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp331Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.9	74.2	27	0.369	41.7	154	-87.3	57.6	10.1604278074866	-4.8	0	0	31.42	3	6	0	0	7	20.4444534742311	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-0.81	-4.326	3.516	NA	NA	NA	0.002274333	0	0.065004233	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.175	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K332A	332	K	A	missense	possibly_wt-like	0.767308993227104	0.208226401345189	7	0.078702182051042	0.613055550902347	0.921562435551861	0.729013287378891	0.756180313143666	0.957303545539653	1.05845378008115	0.711446652444297	NA	0.758187868153834	0.400577505848232	0.656809921595079	0.653960119245849	0.656809921595079	0.763563660640342	0.759883817300478	0.645881442190381	NA	0.695942248624998	0.495358816833041	p.Lys332Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.173	-3.02	1.847	3.336	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K332C	332	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.173	-4.996	3.823	0.835	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332D	332	K	D	missense	wt-like	0.828837390762804	0.0594505390306182	3	0.0343237847127958	0.761564008912617	0.89611077261299	NA	0.773056637630804	0.822075966855361	0.891379567802246	NA	NA	NA	NA	0.686613164009691	NA	0.664589623162551	0.69724096169906	0.686613164009691	NA	NA	NA	NA	p.Lys332Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.173	-3.339	2.166	4.514	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.805	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K332E	332	K	E	missense	possibly_low	0.596136086976113	0.358360792024571	3	0.206899699742393	0.190620127068871	1.00165204688336	NA	0.91770138072977	0.660895628282164	0.209811251916406	NA	NA	NA	NA	0.618189667765881	NA	0.73126841542394	0.618189667765881	0.387710328640397	NA	NA	NA	NA	p.Lys332Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.173	-2.304	1.131	14.816	14.816	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.805	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K332F	332	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.173	-4.234	3.061	1.043	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332G	332	K	G	missense	possibly_wt-like	0.808065706980733	0.234631087000842	7	0.0886822151498554	0.634251759217784	0.981879654743681	NA	0.82592716436339	1.03229322878833	1.12562972378377	0.755099345751686	0.394929478461281	0.783693025679418	0.738887982037254	0.688962046198625	NA	0.688962046198625	0.800342535439362	0.789343930943264	0.662187374418209	0.485991692605291	0.70967915795285	0.665274596150092	p.Lys332Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.173	-3.35	2.177	1.961	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K332H	332	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.173	-4.453	3.28	1.255	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332I	332	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.173	-3.894	2.721	2.418	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K332K	332	K	K	synonymous	possibly_wt-like	0.877476505426824	0.308591786577704	6	0.125982069321537	0.630556186858784	1.12439682399486	NA	1.07365696011883	0.976807767859467	1.19299054082736	0.447387063118314	1.03889718901432	NA	0.535119511622644	0.788145433680849	NA	0.803161312858677	0.77312955450302	0.818885121074665	0.547245196831184	0.803385790368096	NA	0.562932277813497	p.Lys332=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	0	-3.9	-3.9	0	230	230	0	11.3	11.3	0	146	146	0	9.74	9.74	0	NA	NA	NA	NA	NA	NA	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
K332L	332	K	L	missense	possibly_wt-like	0.890679937712097	0.290963684110249	6	0.118785426625077	0.657864779638721	1.12349509578547	NA	1.13525225219487	1.15987398680307	1.08789832557535	0.453077662326008	0.64614983554838	NA	0.861827563824897	0.749908765167093	NA	0.831555705884131	0.862914832354232	0.772796768107084	0.549370850897085	0.609811345781429	NA	0.727020762227102	p.Lys332Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.173	-3.327	2.154	2.982	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K332M	332	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.173	-4.499	3.326	0.906	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332N	332	K	N	missense	possibly_low	0.661373358640429	0.141107091608811	5	0.0631050097889182	0.537689812210101	0.785056905070756	0.476512503468033	0.851009403874008	0.731951998571693	0.652757031391833	NA	0.594635855896577	NA	NA	0.584421512058689	0.533826175267424	0.700524536489991	0.653039439538953	0.581964882900286	NA	0.584421512058689	NA	NA	p.Lys332Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.173	-3.44	2.267	2.029	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.805	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K332P	332	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.173	-3.646	2.473	1.306	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332Q	332	K	Q	missense	possibly_low	0.599844575812652	0.22048202770081	3	0.127295358044537	0.350350258646229	0.849338892979076	NA	0.371219290659969	0.617151116618532	0.811163320159456	NA	NA	NA	NA	0.59673506430682	NA	0.479349368954326	0.59673506430682	0.651434204976138	NA	NA	NA	NA	p.Lys332Gln	1	0	NA	NA	NA	NA	NA	NA	NA	-0.139	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.173	-3.481	2.308	3.25	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.46	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
K332R	332	K	R	missense	possibly_wt-like	0.847436100262556	0.312472496513282	8	0.110475710609416	0.630907686301631	1.06396451422348	1.07236803761541	0.871235307012666	1.14656940264187	0.959570359674349	0.358450574767484	1.060926704041	0.362224175010171	0.948144241337498	0.743445743336416	0.817320247047283	0.709848337443883	0.856389566292027	0.716518340881297	0.514024054176417	0.814243536698324	0.482678819674217	0.770373145791534	p.Lys332Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.173	-3.183	2.01	2.473	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.15	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K332S	332	K	S	missense	wt-like	0.905873636713905	0.209233622768592	8	0.0739752567559498	0.760884797725141	1.05086247570267	0.618685729951548	0.968841713212827	0.925842334423061	0.958081733890856	1.2473906058978	0.928025277442763	0.996742607883873	0.603379091008516	0.748436742624191	0.601468858038787	0.754843248029387	0.748133432180176	0.715865501749666	0.846076782289761	0.748740053068206	0.824426255285757	0.597215518929342	p.Lys332Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.173	-3.103	1.93	4.217	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.805	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
K332T	332	K	T	missense	wt-like	1.11456566375912	0.199823448279177	4	0.0999117241395887	0.91874228281222	1.31038904470601	NA	1.38742660877118	0.959468353613488	1.14037689111347	NA	NA	NA	0.970990801538325	0.788829555082441	NA	0.947803840282602	0.764625396090637	0.795811323904135	NA	NA	NA	0.781847786260748	p.Lys332Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.173	-2.153	0.98	11.228	11.228	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.46	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K332V	332	K	V	missense	wt-like	1.03000390901762	0.112751187983203	5	0.0504238641748598	0.931174951273554	1.12883286676168	NA	1.02302653196164	0.932428671669205	NA	1.17085476920538	NA	0.909913713213183	1.11379585903869	0.779821537565986	NA	0.779821537565986	0.751363717500314	NA	0.817487752116556	NA	0.777660786304339	0.853571348915168	p.Lys332Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.173	-3.413	2.24	3.266	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332W	332	K	W	missense	wt-like	0.915707593140245	0.0853587401465071	8	0.0301788719955678	0.856558090934888	0.974857095345602	0.900967988893902	1.02401496033779	1.00793395989065	1.0025944031628	0.881532157003356	0.797360254454386	0.873049677813206	0.838207343565862	0.735579364998148	0.735772128534199	0.78027718641258	0.788395472027822	0.735386601462096	0.709414812073114	0.684338831701167	0.757806060402716	0.715157552496902	p.Lys332Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.173	-5.265	4.092	0.256	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K332X	332	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K332Y	332	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys332Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17	75.7	28.9	0.84	67.6	62.9	-53.2	-39.1	59.5652173913044	-2.1	0	0	38.2	1	3	0	0	5	22.0811511896459	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.173	-4.154	2.981	0.845	NA	49.88	0.001856543	0	0.053063095	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
A333C	333	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala333Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.69	-4.764	3.074	1	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
A333D	333	A	D	missense	wt-like	1.01605270821917	0.295275052602082	6	0.120545535441427	0.77978780025688	1.25231761618147	NA	0.986405924639509	0.991084923480207	1.08210187525241	1.4988141852285	0.575436654898779	NA	0.96247268581563	0.773912152537224	NA	0.762940053899156	0.780131820632349	0.770254725884432	0.939992999925531	0.57495875021737	NA	0.777569579190016	p.Ala333Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.69	-3.426	1.736	3.638	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A333E	333	A	E	missense	wt-like	1.0600360786306	0.100983588853125	4	0.0504917944265623	0.961073980039736	1.15899817722146	NA	1.09510777954542	0.926010419285512	1.05248582250805	NA	NA	NA	1.16654029318341	0.78515816995772	NA	0.813049779606503	0.748215869814846	0.757266560308938	NA	NA	NA	0.880062138480106	p.Ala333Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.69	-2.523	0.833	11.941	11.941	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.31	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
A333F	333	A	F	missense	possibly_wt-like	1.06579986807803	0.359397258861744	3	0.207498104149842	0.659111057083996	1.47248867907206	NA	1.44893234439092	1.01234054094741	0.736126718895751	NA	NA	NA	NA	0.790556690557583	NA	0.976156949288899	0.790556690557583	0.618526787845038	NA	NA	NA	NA	p.Ala333Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.69	-4.203	2.513	1.247	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
A333G	333	A	G	missense	wt-like	1.03869906922278	0.108257946352741	8	0.0382749639916762	0.963681518289529	1.11371662015603	1.04427105894461	1.0043488732594	0.804801516557549	1.00969971878872	1.16049795083308	1.11474227825784	1.07424422776245	1.09698692937861	0.808785726512761	0.803952364344815	0.771211451241012	0.688768665015019	0.738502648580603	0.813619088680706	0.840767763525588	0.866168115690491	0.845129096653721	p.Ala333Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.69	-3.183	1.493	3.674	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A333H	333	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala333His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.69	-4.56	2.87	1.398	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.105	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A333I	333	A	I	missense	possibly_wt-like	0.847673843495461	0.24651370532415	7	0.0931734227223941	0.665057290643243	1.03029039634768	0.898492226093858	0.879003679665298	1.03922841789816	1.02827153361583	0.381312511112859	0.66112224681637	NA	1.04628628926586	0.734594218727673	0.734594218727673	0.71342942649846	0.803743916015033	0.746647346596034	0.522563852214067	0.617190838398623	NA	0.81966479867018	p.Ala333Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.69	-3.799	2.109	2.891	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
A333K	333	A	K	missense	possibly_low	0.631764929218119	0.57585002484701	3	0.332467166858274	-0.0198587438661667	1.2833886023024	1.12527476492582	NA	NA	NA	-0.000916513587204604	NA	0.770936536315739	NA	0.702808597065124	0.842492025591283	NA	NA	NA	0.379786852674091	NA	0.702808597065124	NA	p.Ala333Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.69	-2.554	0.864	12.169	12.169	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.505	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
A333L	333	A	L	missense	possibly_wt-like	0.886630001702107	0.297403483698839	7	0.11240795098734	0.666314466190977	1.10694553721324	1.05406919047312	0.497442073647076	0.678208011217516	0.646330417446967	1.36448153566006	NA	1.02239294280099	0.943485840669013	0.76803347310722	0.808614085254781	0.537535947637612	0.626680568605407	0.579146481450025	0.889814673827224	NA	0.838241356197486	0.76803347310722	p.Ala333Leu	0	0	NA	NA	NA	NA	NA	NA	NA	0.492	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.69	-3.327	1.637	3.565	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
A333M	333	A	M	missense	possibly_wt-like	0.861344766591877	0.262800731784019	6	0.107287949483478	0.651064249629107	1.07162528355465	NA	0.517536745096242	0.778640738929771	NA	0.609248833627758	1.12226164818479	1.09678265642099	1.04359797729171	0.747126323207764	NA	0.546799252991219	0.675938047210882	NA	0.607706690962095	0.844473855608464	0.878307164452063	0.818314599204646	p.Ala333Met	0	0	NA	NA	NA	NA	NA	NA	NA	-0.735	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.69	-4.53	2.84	1.083	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
A333N	333	A	N	missense	wt-like	1.00882607139514	0.122916759614822	2	0.0869152742451172	0.838475264168289	1.17917687862199	NA	NA	NA	NA	NA	NA	1.09574134564026	0.921910797150023	0.817471885383237	NA	NA	NA	NA	NA	NA	0.877746321345615	0.757197449420859	p.Ala333Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.69	-3.575	1.885	3.015	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
A333P	333	A	P	missense	possibly_low	0.65493112899912	0.217638087252192	7	0.0822594649550111	0.493705540299764	0.816156717698477	0.700632240054579	0.751958896099683	0.756429299911976	0.696413472587817	0.257043996004118	0.49185535084188	NA	0.930184647493789	0.640457083348299	0.640457083348299	0.65486391938239	0.665044392252606	0.601110482470378	0.476144861038719	0.533763808054516	NA	0.76135297467964	p.Ala333Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.69	-3.721	2.031	1.597	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A333Q	333	A	Q	missense	possibly_low	0.5869586752028	0.528492393088141	4	0.26424619654407	0.06904564692473	1.10487170348087	NA	0.533315877656069	NA	NA	-0.120805722499272	1.11638042535834	NA	0.818944120296067	0.629777901792105	NA	0.554073167545457	NA	NA	0.335003698021934	0.841575161493598	NA	0.705482636038752	p.Ala333Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.69	-2.492	0.802	9.768	9.768	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
A333R	333	A	R	missense	low	0.567407632880388	0.147310567912431	5	0.0658792887312588	0.438286599640005	0.696528666120771	NA	0.6189729367355	0.770643348606052	0.566470517606346	0.367628038944421	NA	NA	0.513323322509621	0.551985184182226	NA	0.593559630210548	0.672015707434362	0.54412379929432	0.517452184208135	NA	NA	0.551985184182226	p.Ala333Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.69	-3.596	1.906	4.708	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
A333S	333	A	S	missense	wt-like	0.954226935538272	0.245907352950475	6	0.100391256454525	0.757463688524678	1.15099018255187	1.02761044587826	0.503982837763686	1.03910499814198	NA	1.17953378626609	NA	1.1180579884098	0.857071556769825	0.799854510174878	0.796025635858041	0.540551129817194	0.803683384491714	NA	0.820729693295294	NA	0.889765917692736	0.724632066924777	p.Ala333Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.69	-2.076	0.386	12.06	12.06	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	low	1.305	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
A333T	333	A	T	missense	wt-like	1.02857607609032	0.0721681406449861	7	0.027276993246938	0.975114151719777	1.08203800046086	0.937481982563513	0.961061447503287	1.04381350824381	1.02637239245653	1.15308632074073	NA	1.00424164969766	1.07397523142669	0.805992684865088	0.753144629331988	0.75125667647573	0.805992684865088	0.745814475313653	0.810850564476883	NA	0.828465189659655	0.833571516069894	p.Ala333Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.69	-2.099	0.409	13.424	13.424	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.76	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
A333V	333	A	V	missense	wt-like	0.982188436850946	0.160438617818081	8	0.0567236173116809	0.871012189847219	1.09336468385467	0.725972542873096	1.02936823480526	1.11894506571125	1.1674438787054	0.90898245597144	0.783514602913891	1.03136036727722	1.09192034655002	0.795213274438615	0.65251340441014	0.782744955848834	0.84284114222404	0.807681593028397	0.719668537117186	0.677514688181828	0.843071151771605	0.842584415272607	p.Ala333Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.69	-3.354	1.664	3.905	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	1.965	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
A333W	333	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala333Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.69	-5.309	3.619	0.307	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A333X	333	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala333Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A333Y	333	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala333Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	14.5	73.7	26.8	0.238	107.5	-129	-74.3	15.6	61.9834710743802	-0.8	0	0	35.15	0	0	0	0	5	24.9871610604326	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.69	-4.194	2.504	1.01	NA	39.95	0.001586934	0	0.045357215	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.655	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N334A	334	N	A	missense	possibly_wt-like	0.721561682828328	0.159638612438907	6	0.0651721906202068	0.593826536419144	0.849296829237513	NA	0.775862125693171	0.843159612481308	0.754357706645751	0.401840646452672	0.766415250571859	0.787734755125208	NA	0.667484895170105	NA	0.665882905944175	0.7075814876113	0.626522015620519	0.530231887294001	0.669086884396035	0.711856006728194	NA	p.Asn334Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.218	-3.311	2.093	2.17	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N334C	334	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn334Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.218	-5.095	3.877	0.45	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N334D	334	N	D	missense	possibly_wt-like	0.817327236334725	0.394729722951389	6	0.161147734590179	0.501483480347755	1.1331709923217	NA	0.904605176920786	1.08251665053091	1.16480020888769	0.954780721417805	0.0739229381268405	NA	0.723337722124322	0.731003603786071	NA	0.725231285871332	0.824974736299889	0.806522207555397	0.73677592170081	0.327776335568353	NA	0.657464508323511	p.Asn334Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.218	-3.176	1.958	1.869	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.87	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N334E	334	N	E	missense	possibly_low	0.681679911771228	0.174973681700209	8	0.0618625384296971	0.560431564456796	0.802928259085659	0.668294027770531	0.479646225948362	0.772390457633476	0.969050390276776	0.497957831503071	0.563918018385342	0.863443353439811	0.638738989212452	0.620023140189212	0.625071321281652	0.529332361344773	0.672872581358829	0.720675822912677	0.566135291794727	0.56928152885405	0.752632157565264	0.614974959096771	p.Asn334Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.218	-3.223	2.005	2.678	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N334F	334	N	F	missense	possibly_low	0.659391753053256	0.230956363739648	7	0.0872933003089834	0.488300028356009	0.830483477750502	0.489879470792389	0.501768855641998	0.688480577332807	0.736529958065715	1.0191971186251	0.835466136668625	NA	0.344420154246153	0.618703629004501	0.540185864448717	0.539530521319438	0.631718773951149	0.618703629004501	0.760837882776765	0.703120180372294	NA	0.467153896106561	p.Asn334Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.218	-4.103	2.885	1.588	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N334G	334	N	G	missense	possibly_wt-like	0.857021283729393	0.232634111013972	8	0.0822485787166417	0.695817031665168	1.01822553579362	1.05350279746546	0.900037896932606	0.975362666569595	1.02261422410047	0.904603912790067	0.744583506105783	0.330330248097202	0.925135017773972	0.733646085725539	0.808344608761286	0.723125846662089	0.772420801017079	0.744166324788988	0.718032985609073	0.658326613774008	0.465500961365633	0.758816807964465	p.Asn334Gly	0	0	NA	NA	NA	NA	NA	NA	NA	1.683	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.218	-3.065	1.847	1.877	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N334H	334	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn334His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.218	-1.76	0.542	18.185	18.185	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	1.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
N334I	334	N	I	missense	low	0.530441174989745	0.110161910433535	6	0.0449734116087237	0.442294907974751	0.618587442004739	NA	0.529473053617267	0.398737299411368	0.537895642097232	0.605011939049119	NA	0.420797026460238	0.690732089303246	0.541946966968308	NA	0.552301690336603	0.489613469849627	0.531592243600012	0.606124050565333	NA	0.514225770467844	0.641088392592991	p.Asn334Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.218	-4.018	2.8	1.138	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N334K	334	N	K	missense	low	0.583459907849168	0.125182542964144	8	0.0442587125080614	0.496714425331255	0.67020539036708	0.689957174817981	0.46923208426485	0.615448967349036	0.762352876168113	0.655448175830933	0.371029054448026	0.553455550995235	0.550755378919167	0.590787508149512	0.635378137971431	0.524531617294086	0.595900241006335	0.630028309536758	0.624963892886166	0.474211826330132	0.585674775292689	0.570785361782148	p.Asn334Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.218	-3.32	2.102	2.327	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N334L	334	N	L	missense	low	0.501716543122622	0.0688089750276861	7	0.0260073479846445	0.450743077739318	0.552690008505925	0.628217346999996	0.521146318288322	0.476673673500868	0.496135627293795	0.396094304301114	NA	0.50600761525821	0.487740916216047	0.539136470328773	0.6060037776172	0.548463205485243	0.527837556427267	0.513278324747156	0.528085411129944	NA	0.560119630598544	0.539136470328773	p.Asn334Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.218	-3.591	2.373	1.934	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N334M	334	N	M	missense	possibly_low	0.64931556116756	0.191180744387289	7	0.0722595293018533	0.507689486196111	0.79094163613901	0.602644959713353	0.885544077885248	0.816892906021951	0.60899821375899	0.344489316543862	NA	0.782279812261634	0.504359641987884	0.593837036215032	0.593837036215032	0.71644444000584	0.694698916750884	0.562774385986026	0.508808996108716	NA	0.70891801054329	0.547483193056923	p.Asn334Met	0	0	NA	NA	NA	NA	NA	NA	NA	3.392	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.218	-4.713	3.495	0.75	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N334P	334	N	P	missense	low	0.343190115378163	0.18478963148094	8	0.065333000756568	0.215139786893362	0.471240443862964	0.370171200643781	0.458967551193142	0.41100781091052	0.634291686843395	0.0519531554328279	0.191120772504938	0.200182077148191	0.427826668348512	0.489431526413601	0.483231480398709	0.519799840295593	0.495631572428493	0.573866877589658	0.39953567398685	0.385539947458529	0.395404016396014	0.509044655752747	p.Asn334Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.218	-3.888	2.67	0.936	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N334Q	334	N	Q	missense	low	0.56313667320894	0.0978591453578617	5	0.0437639402480424	0.477360926501215	0.648912419916666	NA	0.606508193340736	0.708656244547776	0.512190825776491	NA	0.533779012836405	NA	0.454549089543294	0.554426836115717	NA	0.587813593281695	0.641613979615978	0.52031935678612	NA	0.554426836115717	NA	0.522465939875243	p.Asn334Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.218	-3.682	2.464	2.055	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N334R	334	N	R	missense	low	0.509259093630352	0.15652649011792	8	0.0553404712988553	0.400793762997124	0.617724424263581	0.763376699969453	0.55588540424043	0.495351253880444	0.631280309724204	0.25252004562579	0.444171287048622	0.377050839269579	0.554436909284298	0.550737680590278	0.670309424064322	0.564477339465669	0.536998021714886	0.572546233512883	0.474454994442135	0.510261635263387	0.490664363082905	0.572634403254695	p.Asn334Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.218	-3.491	2.273	2.431	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N334S	334	N	S	missense	wt-like	0.911138412162605	0.15173975282516	8	0.0536481040991207	0.805990060289473	1.01628676403574	1.025787931718	0.893910614329002	0.915878182423116	1.11437848257103	0.59682001388355	0.848218948131357	0.923934865881575	0.970178258363209	0.762343088663285	0.7951585264153	0.720301272501292	0.743246489296724	0.784409681768931	0.603064056634956	0.709405692862783	0.785212486492212	0.781439688029845	p.Asn334Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.218	-3.093	1.875	2.166	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
N334T	334	N	T	missense	possibly_low	0.561270597404109	0.240962715759937	8	0.0851931851634891	0.394295022755418	0.7282461720528	0.407259140940667	0.36446231773028	0.794092828697127	0.875708754531864	0.851032454347168	0.386669785738096	0.287326926459978	0.523612570787693	0.529014995331179	0.500877051524834	0.476234518150614	0.6835165626855	0.679740704698004	0.69802201939985	0.481920715634378	0.442339656459579	0.557152939137525	p.Asn334Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.218	-3.354	2.136	1.457	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N334V	334	N	V	missense	low	0.465450242996928	0.234973472600049	8	0.0830756679372231	0.302624925848362	0.628275560145494	0.0646121842683097	0.319630865982493	0.649975294529833	0.854956992572582	0.485100358386869	0.532413216546098	0.347540383322698	0.469372648366543	0.54183235795784	0.337853675281429	0.455567973388445	0.612833763187533	0.67063998750801	0.561332539218212	0.553753672424144	0.474770226488797	0.529911043491536	p.Asn334Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.218	-3.762	2.544	1.271	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N334W	334	N	W	missense	low	0.499583138756768	0.0926822715788709	8	0.0327681313645964	0.435358781441482	0.563807496072054	0.442017574155898	0.511012946958023	0.504353434082606	0.61774694770147	0.374900788398241	0.451673236716619	0.446805206433604	0.648154975607685	0.534823383761982	0.51741429788099	0.543791891842146	0.541413163161418	0.566611156740106	0.520168831239943	0.513959141376374	0.528233604362546	0.619704119968191	p.Asn334Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.218	-5.359	4.141	0.297	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.975	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N334X	334	N	X	nonsense	possibly_low	0.461493285957239	0.32847695543477	6	0.134100155513019	0.198661810830501	0.724324761083978	0.817167209744677	0.212080596680774	0.391510292183169	0.91846013911267	0.127083393683792	NA	NA	0.302658084338353	0.466123971999876	0.69590168555286	0.405989109263953	0.486068966359246	0.698489390294631	0.427599659971729	NA	NA	0.446178977640507	p.Asn334Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N334Y	334	N	Y	missense	possibly_low	0.680021354255337	0.148068698636111	7	0.0559647076491596	0.570332542857671	0.789710165653003	0.556207954866983	0.688225833512888	0.770872730486775	0.877764589899331	0.42677545221631	NA	0.693334782102334	0.746968136702742	0.661012804969251	0.57174339970296	0.625484050129213	0.672128208342577	0.680642294466874	0.53954598047109	NA	0.661012804969251	0.669332838130815	p.Asn334Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.1	70.6	28.2	0.816	67.7	131.7	36	49.5	37.4331550802139	-2.2	0	0	32.85	1	12	0	0	8	25.7787516738107	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.218	-3.727	2.509	2.981	NA	51.12	0.001440424	0	0.041169713	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R335A	335	R	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.786	-3.079	1.293	5.212	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R335C	335	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.786	-5.088	3.302	0.832	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335D	335	R	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.786	-3.537	1.751	3.808	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335E	335	R	E	missense	wt-like	1.01320196878833	0.239416149285969	4	0.119708074642984	0.778578453829447	1.24782548374721	NA	1.0409231368462	1.04797150983861	1.27181032657119	NA	0.69210290189732	NA	NA	0.798051779105725	NA	0.788071571225802	0.808031986985647	0.853451659590191	NA	0.632460357205822	NA	NA	p.Arg335Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.786	-3.104	1.318	6.436	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
R335F	335	R	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.786	-4.323	2.537	1.478	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335G	335	R	G	missense	possibly_wt-like	0.852142010002838	0.204449753045589	7	0.0772747431667427	0.700686296481439	1.00359772352424	1.11465384263203	0.6207350905609	0.710239956362567	0.914314116484329	1.08623379657728	0.886564243354751	NA	0.632253024048001	0.696671145681095	0.837438840155266	0.594371953467785	0.642390714975171	0.696671145681095	0.78587861782992	0.728305041667749	NA	0.611717395695379	p.Arg335Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.786	-3.359	1.573	3.955	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	1	2	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
R335H	335	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.786	-4.414	2.628	1.849	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335I	335	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.786	-4.042	2.256	2.438	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335K	335	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.786	-1.334	-0.452	25.095	25.095	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.065	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R335L	335	R	L	missense	wt-like	0.981700494842477	0.184984997871109	4	0.0924924989355547	0.80041852808868	1.16298246159627	NA	0.840695683129361	1.07625527847474	1.19565644728013	NA	NA	0.814194570485679	NA	0.773080673458312	NA	0.69577008480208	0.821903830957345	0.820054258458239	NA	NA	0.726107088458385	NA	p.Arg335Leu	1	0	NA	NA	NA	NA	NA	NA	NA	-0.88	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.786	-3.414	1.628	3.837	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	1.655	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
R335M	335	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.786	-4.511	2.725	1.415	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335N	335	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.786	-3.479	1.693	3.8	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R335P	335	R	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.786	-3.774	1.988	2.456	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
R335Q	335	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.786	-2.662	0.876	9.131	9.131	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	1.655	Neutral	DAMAGING	effect	DAMAGING	null	D	D	T	D	D	D	0.642857142857143
R335S	335	R	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.786	-2.533	0.747	10.041	10.041	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.455	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
R335T	335	R	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.786	-3.423	1.637	3.75	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
R335V	335	R	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.786	-3.648	1.862	3.015	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335W	335	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.786	-5.354	3.568	0.424	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
R335X	335	R	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Ter	1	0	yes	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	9	4	2	4	0	2	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R335Y	335	R	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg335Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	16.6	69.2	24.8	0.743	75.7	25.5	-98.4	-27.6	69.811320754717	-0.4	0	0	36.69	0	0	0	0	5	26.1786916758649	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.786	-4.194	2.408	1.556	NA	42.68	0.003792685	0	0.108401246	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.35	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y336A	336	Y	A	missense	possibly_wt-like	0.714067820472588	0.268395242921903	4	0.134197621460952	0.451045315598183	0.977090325346993	NA	NA	0.780806500622803	NA	1.06409850048622	NA	0.539477674746354	0.471888606034977	0.627573316932246	NA	NA	0.67700025036606	NA	0.777610247414326	NA	0.578146383498433	0.531174678341915	p.Tyr336Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.412	-3.278	0.866	9.895	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.2	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
Y336C	336	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.412	-3.022	0.61	19.428	19.428	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.2	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
Y336D	336	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.412	-3.847	1.435	7.237	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.2	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	D	0.642857142857143
Y336E	336	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.412	-3.736	1.324	4.675	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.85	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y336F	336	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.412	-3.021	0.609	19.703	19.703	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	medium	2.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
Y336G	336	Y	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.412	-3.59	1.178	6.068	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.2	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y336H	336	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.412	-2.968	0.556	14.671	14.671	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.357142857142857
Y336I	336	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.412	-2.938	0.526	10.28	9.096	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336K	336	Y	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.412	-2.966	0.554	12.65	12.65	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336L	336	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.412	-2.357	-0.055	33.545	33.545	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.955	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336M	336	Y	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.412	-3.013	0.601	7.315	7.315	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y336N	336	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.412	-2.573	0.161	27.507	27.507	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.5	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
Y336P	336	Y	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.412	-4.148	1.736	2.637	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.2	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y336Q	336	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.412	-4.091	1.679	2.996	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.65	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336R	336	Y	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.412	-3.965	1.553	4.894	NA	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.505	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Y336S	336	Y	S	missense	possibly_low	0.672372214320254	0.1013254756228	2	0.071647930919834	0.531944850150566	0.812799578489942	0.60072428340042	NA	0.744020145240088	NA	NA	NA	NA	NA	0.625940757656647	0.592923223525008	NA	0.658958291788285	NA	NA	NA	NA	NA	p.Tyr336Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.412	-2.674	0.262	19.919	19.919	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	medium	2.2	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	D	0.428571428571429
Y336T	336	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.412	-2.887	0.475	10.801	10.801	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.85	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336V	336	Y	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.412	-2.808	0.396	12.96	12.96	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.225	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y336W	336	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr336Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.412	-3.354	0.942	24.766	24.766	85.11	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y336X	336	Y	X	nonsense	low	0.106999617825399	0.103630486886506	5	0.0463449626439257	0.0161651601784502	0.197834075472347	NA	0.191135769595433	0.175369245685102	0.0626719484797453	-0.0552273565657613	NA	0.161048481932475	NA	0.374326920572869	NA	0.396333896469813	0.380062057892651	0.323182160346189	0.359499698371641	NA	0.374326920572869	NA	p.Tyr336Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	9	4	4	0	0	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Y336Y	336	Y	Y	synonymous	wt-like	1.00090881866416	0.222313404618104	3	0.128352704000725	0.749342141504414	1.25247549582391	0.971955483063225	NA	NA	NA	0.79449065143883	NA	NA	1.23628032149044	0.769546311392645	0.769546311392645	NA	NA	NA	0.676901517171721	NA	NA	0.91508893219004	p.Tyr336=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.2	68.1	24.9	0.692	134.3	22.6	-105.4	-27.1	45.8823529411765	-3.4	0	0	31.68	0	0	0	0	6	24.6365167558241	0	-1.3	-1.3	0	255	255	0	6.2	6.2	0	181	181	0	5.66	5.66	0	NA	NA	NA	NA	NA	NA	0.002713786	0	0.077564509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
F337A	337	F	A	missense	low	0.365810651091033	0.112341946029998	6	0.0458634074141303	0.275920024351051	0.455701277831016	0.367412596127311	0.258267309948522	0.332573276729851	0.559672623147143	0.413811980307195	NA	NA	0.263126120286177	0.469541081576227	0.481919001144953	0.42728040677837	0.457163162007502	0.541142572202276	0.53470363333574	NA	NA	0.426324125507266	p.Phe337Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.104	-3.331	2.227	2.009	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337C	337	F	C	missense	low	0.314626958708597	0.144126326776951	8	0.0509563515057452	0.214754344973773	0.414499572443421	0.258279087227926	0.326485834288703	0.446575537540232	0.480857000923395	0.464521173423063	0.221048812652769	0.0653603689596153	0.253887854653074	0.444361919300693	0.429995840189872	0.458727998411515	0.513075851533686	0.506577859604898	0.553645435172631	0.400290661112125	0.322789935147749	0.421684224543308	p.Phe337Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.104	-4.913	3.809	0.535	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F337D	337	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe337Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.104	-2.624	1.52	15.849	15.849	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F337E	337	F	E	missense	low	0.300954051429189	0.13985201647128	7	0.052859093704845	0.197352131512265	0.404555971346113	0.125823398973772	0.281488428765542	0.315594226736559	0.375246471244512	0.191103295606182	0.559173457642369	NA	0.258249081035385	0.448835745130187	0.36697653392916	0.437984951751828	0.448835745130187	0.460262199046582	0.451513515060298	0.56694306443787	NA	0.423874642019811	p.Phe337Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.104	-3.674	2.57	3.662	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337G	337	F	G	missense	low	0.250596145320554	0.0529146114006118	8	0.0187081402726118	0.213928864168512	0.287263426472596	0.212675478264211	0.214348938639107	0.190779740863688	0.34395230716263	0.30114694737045	0.211083040172026	0.265477933022231	0.265304777070088	0.417858532756731	0.408298713869682	0.40703477673155	0.387620173198787	0.446538095157702	0.492618981683752	0.395378804021778	0.430571932952751	0.427418351643781	p.Phe337Gly	0	0	NA	NA	NA	NA	NA	NA	NA	14.352	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.104	-3.55	2.446	1.879	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337H	337	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe337His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.104	-4.333	3.229	2.351	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337I	337	F	I	missense	low	0.554717458980589	0.101882501027218	5	0.0455632396029103	0.465415150339916	0.644019767621262	NA	0.41794654246423	0.650229701674013	0.548666260942429	NA	NA	0.499203035409692	0.657541754412582	0.556454728850751	NA	0.50088984563705	0.612958537797832	0.536315715094321	NA	NA	0.556454728850751	0.624418611384117	p.Phe337Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.104	-3.457	2.353	2.135	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F337K	337	F	K	missense	low	0.337568396064981	0.287499677228165	7	0.108664663993866	0.124589568244856	0.550547223885105	NA	0.292079521751153	0.285194041385891	0.282339160999114	-0.0472993213309859	0.87002499721598	0.172353715431005	0.508286657002708	0.433925899369518	NA	0.44286726737477	0.433925899369518	0.419517554949107	0.362461119430538	0.720153298933034	0.380415844640235	0.549455528717793	p.Phe337Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.104	-3.834	2.73	1.822	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.305	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337L	337	F	L	missense	low	0.506332348946305	0.150685782127711	6	0.061517212950848	0.385760827133362	0.626903870759248	NA	0.670944158480967	0.47102998931322	0.534861534920193	NA	0.231617379144631	0.532556757654771	0.596984274164051	0.552340227250757	NA	0.617517488782466	0.525069597620795	0.530261631221336	NA	0.405499618908239	0.574418823280179	0.594003734594558	p.Phe337Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.104	-3.042	1.938	3.414	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F337M	337	F	M	missense	low	0.450711725400299	0.206352090260399	8	0.0729564811675734	0.30771964987308	0.593703800927517	0.752215876725099	0.410568403179425	0.511160561190951	0.624113386009472	0.144015542078725	0.589509229205701	0.336733258690993	0.237377546122023	0.521120191505358	0.664999366433516	0.497488647597585	0.544751735413132	0.569403168072077	0.43392445790012	0.581894737771016	0.468949580566042	0.413391954163685	p.Phe337Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.104	-4.376	3.272	0.883	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337N	337	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe337Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.104	-3.963	2.859	2.771	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337P	337	F	P	missense	low	0.239049873339043	0.206725893967029	6	0.0843954928066536	0.0736377469804928	0.404461999697593	NA	0.0374809812984786	0.439742819212959	0.522657493725025	0.0141189509813856	0.216175847413509	NA	0.204123147402901	0.39728945332395	NA	0.325501625007239	0.509724728005635	0.524909530146246	0.385403167446308	0.397888909626455	NA	0.396689997021446	p.Phe337Pro	0	0	NA	NA	NA	NA	NA	NA	NA	16.526	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.104	-4.217	3.113	0.922	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337Q	337	F	Q	missense	low	0.423246212217997	0.0299669520010757	2	0.0211898349714524	0.381714898835603	0.464777525600391	0.402056377246545	NA	NA	NA	NA	NA	NA	0.44443604718945	0.507894191364505	0.498401698725995	NA	NA	NA	NA	NA	NA	0.517386684003014	p.Phe337Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.104	-4.192	3.088	1.228	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337R	337	F	R	missense	low	0.243857771664925	0.22828531937039	8	0.0807110486860698	0.0856670230857692	0.40204852024408	-0.0919577852587015	0.417010206337352	0.471229797472554	0.409069122006694	-0.0854963922623207	0.142542645920011	0.38985914179237	0.298605437311439	0.45961935910585	0.263361360221916	0.500458210440684	0.525167594024535	0.475095174666028	0.34819306853338	0.361597115534256	0.497562830195794	0.444143543545672	p.Phe337Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.104	-4.118	3.014	1.431	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337S	337	F	S	missense	low	0.282165307075425	0.324189638532903	6	0.132349865717155	0.0227643369110882	0.541566277239761	0.253775838933887	0.258543035648361	0.304098334940755	0.56630721179665	-0.297988183794523	NA	NA	0.60825560492742	0.435525428542587	0.427853300392974	0.427407511685654	0.4431975566922	0.544052181279789	0.268819346337247	NA	NA	0.599664738569877	p.Phe337Ser	1	0	NA	NA	NA	NA	NA	NA	32.2	12.011	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.104	-3.577	2.473	2.089	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F337T	337	F	T	missense	low	0.264077833821711	0.125352048590054	8	0.0443186417968264	0.177214892056199	0.350940775587222	0.374081078004839	0.260475046687867	0.336776794546082	0.384760198624236	-0.0133625469209764	0.269895730903031	0.232314846463872	0.267681522264733	0.428455101779833	0.485091708238721	0.428298136259972	0.459224787670941	0.46443445885158	0.375137788420101	0.424365973107537	0.41271051364464	0.428612067299694	p.Phe337Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.104	-3.647	2.543	1.455	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F337V	337	F	V	missense	possibly_low	0.563869810538395	0.521557485113835	7	0.197130200005069	0.177501718263283	0.950237902813507	0.383227683882953	0.247569995278015	0.596432855831565	0.601285757385549	1.65945922740996	0.0383120228138194	NA	0.420801131166905	0.505516093354146	0.489443448542791	0.422349124746354	0.586573742288558	0.559392076356965	1	0.31022468794525	NA	0.505516093354146	p.Phe337Val	1	0	NA	NA	NA	NA	NA	NA	NA	9.037	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.104	-3.373	2.269	2.393	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F337W	337	F	W	missense	low	0.484504284081688	0.118792621998055	3	0.0685849522883184	0.350080247715186	0.61892832044819	NA	0.620224443197057	0.399418762629905	0.433869646418102	NA	NA	NA	NA	0.489947695163149	NA	0.594136553627023	0.489947695163149	0.485971482869382	NA	NA	NA	NA	p.Phe337Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.104	-4.485	3.381	1.371	NA	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.995	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F337X	337	F	X	nonsense	low	0.152833065313586	0.129114848034143	7	0.0488008254948912	0.0571852049277749	0.248480925699397	0.0894598899207416	0.413585285686608	0.138029551560423	0.215394562841861	0.0423818786505118	NA	0.0493425547856123	0.121637733749342	0.361748712966375	0.34967563017839	0.498879379660595	0.361748712966375	0.39015889825179	0.395960440050029	NA	0.31416284626512	0.35526185828594	p.Phe337Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F337Y	337	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe337Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	20.6	67.5	28.6	0.999	78.3	-129.6	-139.6	136.8	1.31578947368421	-1	0	0	34.29	0	0	0	0	6	25.1436130629629	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.104	-2.184	1.08	15.831	15.831	39.95	0.003127545	0	0.089390431	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	1.61	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S338A	338	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.068	-2.751	1.683	2.528	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.085	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
S338C	338	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.068	-4.743	3.675	0.423	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S338D	338	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.068	-3.309	2.241	1.45	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S338E	338	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.068	-3.255	2.187	1.669	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338F	338	S	F	missense	low	0.642656578602826	0.0146973302791279	2	0.0103925819057097	0.622287492361253	0.6630256648444	NA	NA	NA	NA	0.632263996697117	NA	0.653049160508536	NA	0.627809480163897	NA	NA	NA	NA	0.616303724977355	NA	0.639315235350438	NA	p.Ser338Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.068	-4.096	3.028	0.99	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
S338G	338	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.068	-3.014	1.946	1.599	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S338H	338	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.068	-2.807	1.739	11.333	11.333	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S338I	338	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.068	-3.85	2.782	1.18	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338K	338	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.068	-3.297	2.229	1.848	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.735	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338L	338	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.068	-3.423	2.355	1.658	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338M	338	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.068	-4.545	3.477	0.478	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S338N	338	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.068	-3.299	2.231	1.746	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S338P	338	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.068	-2.521	1.453	22.343	22.343	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	1.985	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
S338Q	338	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.068	-3.714	2.646	1.281	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S338R	338	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.068	-3.718	2.65	1.515	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.39	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338T	338	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.068	-3.094	2.026	1.583	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.39	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
S338V	338	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.068	-3.569	2.501	1.459	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
S338W	338	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.068	-5.332	4.264	0.185	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
S338X	338	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S338Y	338	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser338Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.8	66.9	31.1	0.439	37.2	-97.6	-80.6	159.6	21.6783216783217	-2.3	0	0	33.29	1	1	0	0	5	27.7534105626678	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.068	-4.039	2.971	1.858	NA	45.16	0.002497556	0	0.071384318	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	3.085	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
P339A	339	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.169	-2.181	1.012	14.447	14.447	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.05	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P339C	339	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.169	-5.026	3.857	1.069	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P339D	339	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.169	-3.426	2.257	3.638	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339E	339	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.169	-2.305	1.136	11.941	11.941	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	1.975	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339F	339	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.169	-4.425	3.256	1.099	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
P339G	339	P	G	missense	possibly_wt-like	0.714313540305569	0.0657154487516171	5	0.0293888421161039	0.656712468210672	0.771914612400467	NA	0.640170214339785	0.809855009583111	0.675798879312369	NA	0.745441790078223	0.700301808214358	NA	0.658749638504274	NA	0.603331218445289	0.691247163112797	0.592069920818084	NA	0.658749638504274	0.664765199201267	NA	p.Pro339Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.169	-3.324	2.155	3.908	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339H	339	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.169	-4.594	3.425	1.098	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P339I	339	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.169	-3.976	2.807	2.142	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339K	339	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.169	-3.336	2.167	5.514	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339L	339	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.169	-3.526	2.357	2.969	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
P339M	339	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.169	-4.692	3.523	0.901	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P339N	339	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.169	-3.812	2.643	1.75	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
P339Q	339	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.169	-3.762	2.593	2.619	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P339R	339	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.169	-2.733	1.564	15.708	15.708	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.395	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P339S	339	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.169	-3.317	2.148	4.202	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P339T	339	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.169	-3.433	2.264	2.499	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
P339V	339	P	V	missense	possibly_wt-like	0.763660959261331	0.103688442682109	7	0.039190547595491	0.686848897439766	0.840473021082897	0.883148923962467	0.649146270462199	0.643171302629023	0.886139910864509	0.696747015143069	NA	0.819359794799094	0.767913496968958	0.679852604626967	0.727294235851789	0.607469029254656	0.609496728606075	0.684315304384253	0.640390571606071	NA	0.728889044146376	0.679852604626967	p.Pro339Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.169	-3.514	2.345	3.406	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
P339W	339	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.169	-5.499	4.33	0.271	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
P339X	339	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P339Y	339	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro339Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	17.7	69	34.2	0.388	116.8	45.2	-67	164.2	38.961038961039	-0.2	0	0	35.87	0	0	0	0	4	27.1711736562851	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.169	-4.339	3.17	0.874	NA	49.88	0.00195637	0	0.055916302	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N340A	340	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.429	-3.288	1.859	4.683	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N340C	340	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.429	-5.183	3.754	0.753	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340D	340	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.429	-1.739	0.31	20.181	20.181	83.37	0.001785702	0	0.051038342	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 17, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.625	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
N340E	340	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.429	-2.468	1.039	13.047	13.047	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.83	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N340F	340	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.429	-4.369	2.94	1.32	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340G	340	N	G	missense	wt-like	1.12908359088976	0.2186174101448	5	0.0977686780297451	0.937460503135363	1.32070667864415	NA	NA	1.10246107097971	NA	1.50887036792206	0.981065910881716	1.06698091421913	0.986039690446161	0.834756526418845	NA	NA	0.834756526418845	NA	0.943749364563036	0.774882332749692	0.862256143005583	0.7894060614742	p.Asn340Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.429	-2.393	0.964	19.61	19.61	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.32	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
N340H	340	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.429	-4.283	2.854	2.553	NA	83.37	0.001785702	0	0.051038342	4.068e-06	1	245804	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: May 12, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N340I	340	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.429	-4.106	2.677	2.168	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
N340K	340	N	K	missense	wt-like	1.07688197153853	0.0636696388046889	3	0.0367596831030934	1.00483431657336	1.1489296265037	NA	1.11111551210547	1.00341920378667	1.11611119872346	NA	NA	NA	NA	0.78618119877978	NA	0.820429074913605	0.78618119877978	0.785169567108052	NA	NA	NA	NA	p.Asn340Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.429	-3.353	1.924	7.536	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N340L	340	N	L	missense	wt-like	0.850553572614127	0.201386136293281	8	0.0712007513049688	0.711002664384195	0.990104480844059	0.984031152165063	1.01727718402274	0.905506610280415	0.778808108963546	0.483978590677218	0.988840138123148	0.62922183373854	1.01676496294235	0.756725678700936	0.775291631200818	0.777171184925144	0.738159726201054	0.637244777240108	0.560913516544854	0.77871403704272	0.62648199458193	0.804837769885149	p.Asn340Leu	0	0	NA	NA	NA	NA	NA	NA	NA	1.147	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.429	-3.713	2.284	3.936	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N340M	340	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.429	-4.805	3.376	1.801	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340P	340	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.429	-3.847	2.418	2.06	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340Q	340	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.429	-2.775	1.346	17.836	17.836	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
N340R	340	N	R	missense	wt-like	0.936109627425727	0.092747559633401	4	0.0463737798167005	0.845218689158003	1.02700056569345	NA	0.983060590087182	0.90116021570509	1.03572243196969	NA	NA	NA	0.824495271940943	0.7429714879159	NA	0.761397910971038	0.736028026279307	0.749914949552493	NA	NA	NA	0.708270691166312	p.Asn340Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.429	-3.678	2.249	6.05	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
N340S	340	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.429	-3.13	1.701	4.607	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N340T	340	N	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.429	-3.407	1.978	3.358	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
N340V	340	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.429	-3.786	2.357	2.838	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340W	340	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.429	-5.507	4.078	0.553	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.87	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
N340X	340	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N340Y	340	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn340Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	19.4	67	37	0.235	80.5	144.2	82.8	-18.1	66.3101604278075	-0.5	0	0	39.05	0	0	0	0	3	28.6413005616016	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.429	-4.293	2.864	1.645	NA	83.37	0.001785702	0	0.051038342	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.87	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
F341A	341	F	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.074	-3.26	2.186	3.914	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F341C	341	F	C	missense	possibly_low	0.459690684466863	0.363823394973381	5	0.162706768593047	0.140791277983599	0.778590090950128	NA	0.621056402737323	0.530504718234905	0.939184444200064	0.0164969906579999	NA	0.191210866504025	NA	0.55423912486713	NA	0.594520072973574	0.55423912486713	0.707578066231143	0.386291455221106	NA	0.390572181616858	NA	p.Phe341Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.074	-4.82	3.746	1.345	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	3	0	1	0	1	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F341D	341	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.074	-3.959	2.885	1.516	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341E	341	F	E	missense	low	0.341100046469746	0.0568224799085525	3	0.0328064740712249	0.276800538830398	0.405399554109094	NA	0.286233874656157	0.337371110364977	0.399695154388103	NA	NA	NA	NA	0.459516271327722	NA	0.440172522443639	0.459516271327722	0.470984206719675	NA	NA	NA	NA	p.Phe341Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.074	-3.906	2.832	1.497	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F341G	341	F	G	missense	low	0.279233317674189	0.123784486526	8	0.0437644249141146	0.193456621038417	0.365010014309961	0.318782463022828	0.184394535741005	0.305661891805611	0.43071211947234	0.0496775833765298	0.307347700873457	0.227918796683192	0.409371450418547	0.443394716649306	0.458781925704823	0.393226301114915	0.443964407006569	0.484586744560917	0.398685661744347	0.442825026292042	0.410342830277958	0.499775558406545	p.Phe341Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.074	-3.648	2.574	1.7	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.825	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
F341H	341	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.074	-4.561	3.487	0.713	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341I	341	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.074	-2.48	1.406	22.639	22.639	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F341K	341	F	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.074	-3.893	2.819	1.922	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F341L	341	F	L	missense	low	0.409163186963626	0.129627266306093	8	0.0458301595158565	0.319337724906822	0.498988649020431	0.566576259003932	0.409004574117001	0.545251547856948	0.463591933923612	0.276831298386132	0.179743922690313	0.392504255241876	0.439801704489197	0.498996854343123	0.576676395351715	0.496767748718361	0.561471743766892	0.499006237863108	0.483536166984967	0.379932608886856	0.498987470823137	0.5150590943865	p.Phe341Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.074	-2.236	1.162	18.077	18.077	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	deleterious	deleterious	medium	2.825	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F341M	341	F	M	missense	low	0.566836747739885	0.0751994432029171	4	0.0375997216014586	0.493142647572293	0.640530847907476	NA	0.540017793498678	0.518429515620713	0.530042641036958	NA	NA	NA	0.678857040803189	0.55273972498521	NA	0.557162637958612	0.548316812011808	0.528148297881932	NA	NA	NA	0.635124172557465	p.Phe341Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.074	-4.177	3.103	3.079	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341N	341	F	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.074	-4.139	3.065	1.221	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341P	341	F	P	missense	low	0.27979327320469	0.059405129978124	3	0.0342975677841146	0.212571275590504	0.347015270818876	NA	0.260603024651397	0.346421460156112	0.23235533480656	NA	NA	NA	NA	0.428357131947347	NA	0.428357131947347	0.463955037667776	0.397597070936962	NA	NA	NA	NA	p.Phe341Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.074	-4.287	3.213	1.236	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341Q	341	F	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.074	-4.335	3.261	1.094	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341R	341	F	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.074	-4.144	3.07	1.527	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341S	341	F	S	missense	low	0.197387644490131	0.269656839767938	7	0.101920705336222	-0.00237326724778414	0.397148556228047	NA	0.210953449813221	0.378130331550719	0.39897409070201	-0.348369550675429	0.0547218506098298	0.373726968025567	0.313576371405002	0.451662666105124	NA	0.405469513527396	0.479506731721118	0.470667983128831	0.25	0.318312643913235	0.488874147992069	0.451662666105124	p.Phe341Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.074	-3.626	2.552	2.115	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.17	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.857142857142857
F341T	341	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.074	-3.604	2.53	3.309	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.875
F341V	341	F	V	missense	possibly_wt-like	0.733375888684029	0.172173132907092	2	0.121744789816738	0.494760485337824	0.971991292030233	0.611631098867291	NA	NA	NA	0.855120678500766	NA	NA	NA	0.648830777994345	0.59811243021968	NA	NA	NA	0.699549125769011	NA	NA	NA	p.Phe341Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.074	-3.103	2.029	14.698	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	8	0	2	0	1	0	2	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F341W	341	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.074	-4.576	3.502	0.444	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F341X	341	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe341Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F341Y	341	F	Y	missense	low	0.413877794711843	0.0992233205323808	6	0.0405077509814924	0.334484061693401	0.493271527730285	NA	0.361002477955934	0.491454999138975	0.441310393890474	0.335286204068739	NA	0.298395158030087	0.555817535186849	0.497302959804266	NA	0.474639590242218	0.535087093983049	0.48923463414112	0.505371285467411	NA	0.448300932854196	0.573327819931648	p.Phe341Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	22.2	66.2	34.5	0.296	24.9	172.3	-52.6	136.8	0.43859649122807	-3.5	0	0	28.94	0	0	0	0	8	26.8353576063372	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.074	-3.206	2.132	1.697	NA	83.37	0.002813408	0	0.080411887	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.17	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K342A	342	K	A	missense	possibly_wt-like	0.961273894122312	0.30529588259657	5	0.136532469347345	0.693675171481196	1.22887261676343	1.02697555841073	0.436399473118869	NA	NA	1.1388131502248	1.20657398141742	0.997607307439745	NA	0.805518995369105	0.795723571308871	0.509396336114154	NA	NA	0.805518995369105	0.886029102087617	0.824891976753383	NA	p.Lys342Ala	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.261	-3.115	1.854	3.64	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.845	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
K342C	342	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Cys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.261	-5.107	3.846	0.819	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342D	342	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.261	-3.48	2.219	6.947	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342E	342	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Glu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.261	-3.113	1.852	4.127	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
K342F	342	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.261	-4.34	3.079	1.401	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342G	342	K	G	missense	possibly_low	0.50687172433632	0.396599704802757	4	0.198299852401378	0.11821115549001	0.89553229318263	0.808640836967095	NA	NA	NA	0.552956557537603	-0.0659188747379984	NA	0.731808377578581	0.624199137503101	0.691845037594244	NA	NA	NA	0.586679396439563	0.258852125089489	NA	0.661718878566638	p.Lys342Gly	0	1	NA	NA	NA	NA	NA	NA	NA	2.56	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.261	-3.329	2.068	5.339	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.6	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342H	342	K	H	missense	possibly_wt-like	1.0690947183529	0.834901495452223	2	0.590364509057056	-0.0879984571495982	2.2261878938554	NA	NA	NA	NA	1.65945922740996	NA	NA	0.478730209295846	0.767305430143108	NA	NA	NA	NA	1	NA	NA	0.534610860286216	p.Lys342His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.261	-4.41	3.149	2.671	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.395	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342I	342	K	I	missense	low	0.520012047945448	0.208624627844524	6	0.0851706476661866	0.353080645979771	0.686943449911124	0.710930840216241	0.159503809960972	0.637054380933358	0.669803396164099	NA	NA	0.543294121449621	0.399485738948393	0.584821244460127	0.645356915482341	0.381752095430257	0.606496669298527	0.589440592443132	NA	NA	0.580201896477122	0.494810479028938	p.Lys342Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.261	-4.058	2.797	1.857	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342L	342	K	L	missense	wt-like	0.985996296301974	0.131258388975509	5	0.0587005360732694	0.870945359725172	1.10104723287878	NA	0.921188360544326	0.954330369378494	0.99523073653191	0.856668579186579	NA	NA	1.20256343586856	0.732875854434117	NA	0.732875854434117	0.762105459071147	0.732157254112187	0.700127325228561	NA	NA	0.898154691899519	p.Lys342Leu	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.261	-3.448	2.187	2.557	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342M	342	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Met	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.261	-4.546	3.285	0.989	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K342N	342	K	N	missense	wt-like	0.971595592390556	0.141234514290064	8	0.0499339413960462	0.873726865648171	1.06946431913294	0.703735574258863	1.04236010754134	0.967033016445778	1.07986240313672	1.1849741732731	0.934100622102746	0.950254269912779	0.910444572453131	0.768804052770036	0.641933576892871	0.788733990532677	0.768335503603466	0.769272601936606	0.822761883639307	0.751734424533349	0.799387943608172	0.751438560346113	p.Lys342Asn	1	1	NA	NA	NA	NA	NA	NA	NA	0.62	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.261	-2.621	1.36	26.407	26.407	42.93	0.002432119	0	0.069514001	0	NA	NA	not specified	Uncertain significance(Last reviewed: Apr 17, 2015)	criteria provided, single submitter	0	0	1	0	0	2	0	2	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	.	D	0.928571428571429
K342P	342	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.261	-3.783	2.522	1.606	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342Q	342	K	Q	missense	possibly_wt-like	0.748794865408557	0.379784645542247	4	0.189892322771124	0.3766127518365	1.12097697898061	NA	NA	0.454634183428937	0.903177725903353	1.21401631771703	0.423351234584911	NA	NA	0.604407749340608	NA	NA	0.517028234252885	0.69178726442833	0.833610223184334	0.5	NA	NA	p.Lys342Gln	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.261	-2.702	1.441	2.858	2.601	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
K342R	342	K	R	missense	wt-like	0.976175171635209	0.204887620056779	3	0.118291922593403	0.74432726369014	1.20802307958028	NA	1.15701951390933	1.01785307526388	NA	NA	NA	NA	0.75365292573242	0.793260326586801	NA	0.841590047201081	0.793260326586801	NA	NA	NA	NA	0.672690260432196	p.Lys342Arg	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.261	-2.14	0.879	17.159	17.159	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.05	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K342S	342	K	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.261	-2.54	1.279	7.04	7.04	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.395	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K342T	342	K	T	missense	possibly_wt-like	0.748371732109288	0.281800334351593	5	0.126024940738466	0.5013673871081	0.995376077110476	NA	0.940155777117687	0.811669976823495	0.818153623388502	0.254865597277281	NA	NA	0.917013685939477	0.6921373182649	NA	0.741619514261181	0.6921373182649	0.654499813230737	0.475331146710605	NA	NA	0.754737884830617	p.Lys342Thr	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.261	-3.419	2.158	4.176	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	not specified	Uncertain significance(Last reviewed: Sep 1, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.945	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K342V	342	K	V	missense	possibly_low	0.662578380838626	0.173200441276265	2	0.122471206530949	0.422539226894799	0.902617534782452	NA	NA	NA	NA	NA	0.785049587369575	NA	0.540107174307677	0.621854280902719	NA	NA	NA	NA	NA	0.678271240099584	NA	0.565437321705855	p.Lys342Val	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.261	-3.657	2.396	2.244	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342W	342	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Trp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.261	-5.389	4.128	0.302	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K342X	342	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Ter	1	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K342Y	342	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys342Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	25.4	66.1	36.4	0.979	29.8	-149.9	-148.3	154.8	30.4347826086957	-3.6	0	1	30.06	0	0	0	0	8	26.3036597807225	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.261	-4.21	2.949	1.308	NA	42.93	0.002432119	0	0.069514001	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.945	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343A	343	V	A	missense	low	0.456176152289561	0.174350464120075	7	0.0658982812900584	0.327017894317956	0.585334410261165	0.683552851459285	0.253467841130221	0.377614244853588	0.618502806943681	0.313374295817724	NA	0.339023636976133	0.607697388846291	0.497186358860306	0.63233111129818	0.425067932426077	0.479253615729732	0.566942639975713	0.497186358860306	NA	0.470183163177633	0.599384375627764	p.Val343Ala	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-0.98	-2.894	1.914	1.84	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	N	D	D	D	D	D	0.928571428571429
V343C	343	V	C	missense	wt-like	0.962139523207664	0.209977529034942	6	0.0857229672643414	0.794125594721649	1.13015345169368	0.672221152398648	NA	1.10005114312281	NA	1.27835707304596	0.856711143863911	0.980414697967534	0.885081928847115	0.777166186380312	0.626939754966345	NA	0.833574571367379	NA	0.857643929157369	0.713591264217353	0.815632150885143	0.73870022187548	p.Val343Cys	0	1	NA	NA	NA	NA	NA	NA	NA	4.367	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-0.98	-4.64	3.66	0.632	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343D	343	V	D	missense	low	0.379379284402361	0.240259346198627	7	0.0908094971715056	0.201395940492018	0.557362628312704	0.327593844203016	0.253066816689372	0.378270195034131	0.455573560584887	0.794356517152648	-0.00136609065138651	NA	0.44816014780386	0.479575328110948	0.462974173969078	0.42488306690791	0.479575328110948	0.495489767877441	0.676851412941851	0.290668429428182	NA	0.519257106300546	p.Val343Asp	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-0.98	-3.921	2.941	0.713	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343E	343	V	E	missense	low	0.211358005441246	0.120661482483998	8	0.0426602762462286	0.127745400428109	0.294970610454384	0.256329714716709	0.244996761106103	0.297864952907437	0.388641358751835	-0.0188802171163558	0.215704116575569	0.149114155973463	0.157093200615209	0.409409656739455	0.429068374522524	0.421162907099499	0.440140379125286	0.466136547607208	0.373076729881793	0.397656406379411	0.367899171462771	0.373069297628131	p.Val343Glu	1	1	NA	NA	NA	NA	NA	NA	NA	8.73	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-0.98	-3.706	2.726	0.704	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V343F	343	V	F	missense	low	0.132908938062953	0.165378042485354	3	0.0954810573469724	-0.0542304955429166	0.320048371668822	NA	NA	NA	NA	0.322712485542085	0.0561966381898888	0.0198176904568846	NA	0.319039526434973	NA	NA	NA	NA	0.500674525963852	0.319039526434973	0.298260949411747	NA	p.Val343Phe	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-0.98	-3.798	2.818	1.758	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343G	343	V	G	missense	low	0.272373138901874	0.140385968989149	8	0.0496339353278359	0.175092413248326	0.369653864555423	0.395497440633919	0.347892531919976	0.311284422032384	0.414425877424946	-0.0331332872759059	0.246680805430494	0.237312437299945	0.259024883749234	0.435493139113136	0.495281110697019	0.468596125754251	0.446721990800842	0.47744438801057	0.367752669017471	0.412923970342121	0.415402183049308	0.424264287425431	p.Val343Gly	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-0.98	-3.625	2.645	0.799	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
V343H	343	V	H	missense	low	0.265420914443037	0.224473886861281	4	0.112236943430641	0.0454405475841221	0.485401281301952	NA	0.345287913657415	0.370363767642986	0.414569809228087	NA	-0.0685378327563388	NA	NA	0.471546520949238	NA	0.467395440569787	0.47569760132869	0.477507509524666	NA	0.257561312206036	NA	NA	p.Val343His	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-0.98	-4.908	3.928	0.335	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343I	343	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val343Ile	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-0.98	-1.998	1.018	10.646	10.646	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.33	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V343K	343	V	K	missense	low	0.388715901267752	0.260033240065706	5	0.116290400239288	0.160790905050999	0.616640897484505	NA	0.301668171876873	0.241688866779498	0.293661216592453	0.85167331786682	NA	NA	0.254887933223117	0.424482859879192	NA	0.447287473709974	0.412588679359507	0.424482859879192	0.698261406166781	NA	NA	0.422186512061925	p.Val343Lys	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-0.98	-3.723	2.743	0.904	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343L	343	V	L	missense	wt-like	0.973962768143082	0.116662057427581	8	0.0412462659571085	0.893121572370389	1.05480396391577	0.844049095386902	0.98615869332544	1.06160785718729	1.02103054503774	1.14559232889816	0.959367636920607	0.995423898283868	0.77847209010465	0.763506965259323	0.7086914555241	0.762826084424164	0.814719967120059	0.743471799895253	0.808051275043804	0.764187846094481	0.823716007008056	0.685155637513659	p.Val343Leu	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-0.98	-2.639	1.659	6.571	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	medium	2.79	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
V343M	343	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val343Met	1	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-0.98	-4.032	3.052	1.448	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Sep 26, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V343N	343	V	N	missense	low	0.271247181033957	0.0829593016803589	6	0.0338679930890824	0.204867134350704	0.33762722771721	0.113357920997797	0.338200166966357	0.258518832924907	0.327143672639741	NA	0.278217019394326	NA	0.312045473280613	0.433816975766241	0.36104575221183	0.464128108628861	0.420842977696534	0.439166642582111	NA	0.42846730895037	NA	0.450893775496737	p.Val343Asn	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-0.98	-4.126	3.146	0.574	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343P	343	V	P	missense	low	0.434516246041062	0.110255248226504	7	0.0416725667924323	0.352839515984555	0.516192976097569	0.404548840861059	0.405470281972156	0.40322669807518	0.483852140559871	0.655438873529619	NA	0.381846094887887	0.307230792401663	0.495138499520166	0.499587554387893	0.495138499520166	0.491815306478696	0.507891382708603	0.624960418124742	NA	0.493247056076136	0.448475611380375	p.Val343Pro	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-0.98	-3.921	2.941	0.581	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343Q	343	V	Q	missense	low	0.249949353801057	0.136081760620657	6	0.0555551461366957	0.141063268217274	0.35883543938484	NA	0.172913603488911	0.344967505008781	0.172008082071224	0.141820529440278	NA	0.182773409624311	0.485212993172835	0.410519161106641	NA	0.387933784565726	0.463241941785643	0.371131690242298	0.433104537647555	NA	0.386027823088665	0.537866825892162	p.Val343Gln	0	1	NA	NA	NA	NA	NA	NA	NA	5.162	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-0.98	-4.166	3.186	0.514	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343R	343	V	R	missense	low	0.318629162406075	0.174481698223961	8	0.0616885960035539	0.197721735982268	0.439536588829882	0.232425723566911	0.185197079193263	0.637362624549664	0.549448692056331	0.184921050523341	0.214808232229689	0.266159729890053	0.278710167239348	0.432545163525105	0.417695416826423	0.393596260139954	0.606647848139143	0.536658851465211	0.449204212662235	0.397214849451943	0.430939144241052	0.434151182809157	p.Val343Arg	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-0.98	-4.161	3.181	0.718	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343S	343	V	S	missense	low	0.319936433681216	0.125104206830767	8	0.0442310165024998	0.233245234336719	0.406627633025712	0.478210400580951	0.430632481762321	0.357994623976174	0.423869216363111	0.237988076532392	0.103208383723343	0.261321218122475	0.266267068388958	0.469328939318134	0.534633994845191	0.506737850154707	0.469631124360329	0.481585778856038	0.469026754275938	0.342210331916867	0.428333153771623	0.427901660588918	p.Val343Ser	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-0.98	-3.613	2.633	0.994	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343T	343	V	T	missense	possibly_low	0.60597541851284	0.215202524201174	4	0.107601262100587	0.395080820104635	0.816870016921044	0.29989190274313	NA	0.765320008870679	NA	0.611919344328434	NA	NA	0.746770418109115	0.638968881039601	0.449794240695642	NA	0.669404862353304	NA	0.608704227727863	NA	NA	0.66923353435134	p.Val343Thr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-0.98	-3.238	2.258	1.556	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343V	343	V	V	synonymous	possibly_wt-like	0.926812794421032	0.260864351789279	5	0.116662084701449	0.69815931004483	1.15546627879723	0.888734359476826	NA	0.831489528216614	NA	1.26729205649491	NA	1.07257068644757	0.573977341469243	0.729951654917125	0.729951654917125	NA	0.701857866048027	NA	0.853510726912303	NA	0.865266757395569	0.582448547351852	p.Val343=	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V343W	343	V	W	missense	low	0.237541077383359	0.151675076195318	8	0.0536252374573478	0.132437543304549	0.342644611462169	0.307965151706856	0.245771758225637	0.458299767516041	0.327604939967774	0.0272990368764367	0.0241429829779754	0.188139047319495	0.32110593447666	0.430444549904237	0.45363530298349	0.421520167728745	0.518826028994301	0.439368932079728	0.390326428099397	0.303241155166874	0.388917720099923	0.455444374527664	p.Val343Trp	0	1	NA	NA	NA	NA	NA	NA	NA	8.377	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-0.98	-5.325	4.345	0.209	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
V343X	343	V	X	nonsense	low	0.298687062236106	0.253839327126632	6	0.103629471351945	0.0955770306493689	0.501797093822844	NA	0.202814874217239	0.113340869239746	0.291118332170949	0.239930093404812	0.800120681786555	NA	0.144797522597336	0.412542720571659	NA	0.401717767146286	0.349640087930397	0.423367673997032	0.469752171039664	0.685699370945877	NA	0.366893817234579	p.Val343Ter	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V343Y	343	V	Y	missense	low	0.241793704244227	0.087722861166176	4	0.043861430583088	0.155826879990971	0.327760528497483	NA	0.155161095231404	0.254969019070974	0.358237833565682	NA	NA	NA	0.198806869108846	0.406560934664506	NA	0.3797501770259	0.419101962751043	0.452803034778707	NA	NA	NA	0.394019906577968	p.Val343Tyr	0	1	NA	NA	NA	NA	NA	NA	NA	NA	29	65.2	35.8	0.986	16.5	-159.8	-127.6	114	0	-5.6	0	1	22.5	0	0	0	0	7	25.7163414555803	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-0.98	-3.94	2.96	0.798	NA	39.21	0.00327427	0	0.093584078	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	3.135	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K344A	344	K	A	missense	possibly_low	0.409750586866226	0.504428393609787	8	0.178342368872259	0.0602059669590418	0.75929520677341	-0.0428992582090344	0.887370886109164	0.895095931699337	0.905164490899687	-0.268304863476267	0.042964035832993	0.0604764880209941	0.798136984052935	0.506409036211021	0.286702255441985	0.717286567852689	0.733053783256388	0.692658563279487	0.279907189325493	0.312517538115848	0.320159509142555	0.69503229228962	p.Lys344Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.897	-3.146	1.249	5.612	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
K344C	344	K	C	missense	possibly_wt-like	0.862575321664446	0.243383854897629	7	0.0919904504553368	0.68227735185037	1.04287329147852	0.587181255928406	1.13107494604027	0.87537104907005	0.996293482060254	0.546412750114268	1.14306223089562	NA	0.758631537542252	0.723379666001589	0.586479769059554	0.829630038049077	0.723379666001589	0.732623322801553	0.584235036830284	0.854725894762377	NA	0.67519075854007	p.Lys344Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.897	-3.302	1.405	21.826	21.826	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.175	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K344D	344	K	D	missense	low	0.33864642595621	0.0257645381558592	3	0.0148751630398317	0.309491642133978	0.367801209778441	0.361750698278716	0.343325613731109	NA	NA	NA	NA	NA	0.310862965858804	0.466490853328402	0.47922520309641	0.466490853328402	NA	NA	NA	NA	NA	0.450299863441786	p.Lys344Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.897	-3.543	1.646	7.32	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.52	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K344E	344	K	E	missense	possibly_low	0.679721808482649	0.119855778185504	6	0.048930916546448	0.583818974321076	0.775624642644222	0.654139948958466	0.87303844066668	0.512941732166779	0.739509862685137	NA	0.666176601123569	NA	0.632524265295262	0.619009567269462	0.618337142936783	0.710679551712439	0.545625315104066	0.620010470767997	NA	0.619681991602142	NA	0.611853626084785	p.Lys344Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.897	-2.36	0.463	12.31	12.31	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	low	1.05	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.357142857142857
K344F	344	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys344Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.897	-4.302	2.405	2.237	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K344G	344	K	G	missense	low	0.54630793578046	0.0347324448250762	7	0.013127630204632	0.520578253377021	0.572037618183899	0.523904278005922	0.536780443012142	0.572887639557518	0.60622650167271	0.502271264677756	NA	0.527739129920554	0.554346293616622	0.567746522252385	0.55637406877964	0.5556702738675	0.575025932990747	0.561558847378807	0.567746522252385	NA	0.571824080813135	0.572588891711674	p.Lys344Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.897	-2.712	0.815	22.393	22.393	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.175	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K344H	344	K	H	missense	wt-like	0.976436164908275	0.186673467228633	7	0.0705559386658754	0.838149066227742	1.11472326358881	NA	1.20601106500699	0.957486411817935	0.597092086766233	1.00281502234706	1.07108960457661	1.02600998318745	0.974548980655653	0.783634874808761	NA	0.864174327750901	0.763653347856804	0.557552935643551	0.754718550121194	0.819252552823346	0.840189470251443	0.783634874808761	p.Lys344His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.897	-4.601	2.704	2.814	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K344I	344	K	I	missense	wt-like	1.12450141447187	0.0684368096797615	4	0.0342184048398808	1.05743457337729	1.19156825556645	NA	1.15208669142719	1.18352844475918	NA	1.02617341489259	NA	1.13621710680851	NA	0.856916159279021	NA	0.839316099054043	0.874516219504	NA	0.763443793329358	NA	0.899546298882956	NA	p.Lys344Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.897	-2.75	0.853	13.543	13.543	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	1.975	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K344L	344	K	L	missense	wt-like	0.947400785944933	0.0886943869492388	8	0.0313582012324952	0.885939840909283	1.00886173098058	0.926245731047845	0.878857891601376	0.851183362966618	0.84677790006273	1.07326133144253	1.01988477995989	0.938797715101657	1.04419757537682	0.764415798042716	0.747798684700833	0.713362220654541	0.711516755793981	0.667053033882143	0.781032911384599	0.79401509317437	0.793217518881641	0.818615746177854	p.Lys344Leu	0	0	NA	0.760661964634488	-0.294819130306947	0.608175631743875	0.913148297525101	NA	NA	-3.519	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.897	-3.386	1.489	8.359	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.52	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K344M	344	K	M	missense	wt-like	1.1027492906495	0.103338784869598	2	0.0730715555408705	0.95953167349508	1.24596690780393	NA	NA	NA	NA	1.02967773510863	NA	NA	1.17582084619037	0.824738033842784	NA	NA	NA	NA	0.764752789490147	NA	NA	0.884723278195421	p.Lys344Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.897	-4.605	2.708	1.842	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
K344N	344	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys344Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.897	-2.881	0.984	27.821	27.821	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
K344P	344	K	P	missense	low	0.306639759572953	0.274259612706995	7	0.103660389984514	0.103469128579929	0.509810390565977	NA	0.541907518787989	0.364930711377859	0.38592059553845	-0.210185964157703	0.190662484892932	0.246982681973869	0.626260288597273	0.46494335270672	NA	0.558033769513742	0.473032945505455	0.46494335270672	0.301616796720645	0.385314070010413	0.420610512938295	0.608707555959342	p.Lys344Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.897	-3.947	2.05	1.692	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K344Q	344	K	Q	missense	wt-like	0.896955514959558	0.175642604438593	6	0.071705792994676	0.756414743207108	1.03749628671201	1.06620356147663	NA	1.06308320800765	NA	0.922413837262904	0.592653488005454	0.908454592459324	0.828924402545382	0.750780289806814	0.814387334049381	NA	0.815443556562715	NA	0.724685666106743	0.583444457063654	0.776874913506885	0.710495213406439	p.Lys344Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.897	-2.966	1.069	8.228	8.228	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
K344R	344	K	R	missense	wt-like	1.07949997075628	0.133602248752866	8	0.0472355280374617	0.986920037012124	1.17207990450044	1.08160061625729	1.07092868658633	1.12910216622067	1.25774431679584	1.17837909156975	0.797505918042207	1.07780428585555	1.04293468472262	0.821005631160235	0.821712891173612	0.801903624675832	0.847822717179066	0.847282989324585	0.820298371146858	0.684410625305528	0.868085539457734	0.817981461800619	p.Lys344Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.897	-2.46	0.563	28.087	28.087	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.63	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
K344S	344	K	S	missense	wt-like	0.898629915317418	0.191065790807265	8	0.0675519581662937	0.766230510226326	1.03102932040851	1.17709645856345	1.01380501737844	0.971976475551502	1.00971661158318	0.5902364385447	0.893934780197705	0.674549065511243	0.857724475209131	0.735223917464902	0.867147570591599	0.775570574537154	0.77076003529432	0.738510056941647	0.600604842204906	0.731937777988158	0.650894942132619	0.724959993942276	p.Lys344Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.897	-2.381	0.484	11.296	11.296	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.485	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
K344T	344	K	T	missense	wt-like	0.995236274410719	0.236622570373592	4	0.118311285186796	0.763350416479952	1.22712213234149	NA	1.06902121608373	0.677494882168191	0.991100389498667	1.24332860989229	NA	NA	NA	0.76568509846553	NA	0.80102431287602	0.626330812707204	0.730345884055041	0.844559473126061	NA	NA	NA	p.Lys344Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.897	-3.504	1.607	4.4	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.5
K344V	344	K	V	missense	possibly_wt-like	0.903508949631819	0.329121424098599	8	0.116361995406946	0.675443629464989	1.13157426979865	1.05034066532879	0.618994086735495	1.07156622984193	1.11202979374397	0.253041578538258	1.24424091825031	0.793501048498199	1.0843572761176	0.795109900602568	0.806840140541129	0.5935693800046	0.819604075509376	0.783379660664008	0.474649806713291	0.904594106567885	0.714961694240342	0.838785877843233	p.Lys344Val	0	0	NA	NA	NA	NA	NA	NA	NA	-2.541	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.897	-2.821	0.924	10.823	10.823	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.52	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K344W	344	K	W	missense	wt-like	0.950760875555463	0.101284304147067	5	0.0452957178253212	0.861982899963945	1.03953885114698	1.07432898099726	0.852349264398073	0.870306827242218	1.04196417853924	NA	NA	NA	0.91485512660053	0.752652277130389	0.818253217863177	0.701142189642323	0.72089590593632	0.752652277130389	NA	NA	NA	0.753653752596786	p.Lys344Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.897	-5.456	3.559	0.42	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K344X	344	K	X	nonsense	low	0.246717350551865	0.157967441192425	7	0.0597060806629111	0.129695582794516	0.363739118309214	0.169878004698896	0.0975741766551632	0.377126810053022	0.517923394716093	0.116943342437882	0.304788300732677	0.142787424569324	NA	0.42381196725737	0.387936680880791	0.353203576724696	0.479014552131566	0.522833383729654	0.42381196725737	0.441563567859912	0.364491635729924	NA	p.Lys344Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K344Y	344	K	Y	missense	wt-like	1.03448274063546	0.142396676569361	4	0.0711983382846805	0.894936561838386	1.17402891943253	0.822433758914789	1.12449721103369	1.08291321777124	1.10808677482212	NA	NA	NA	NA	0.803409838659107	0.698407385983419	0.826597812911425	0.825169233679388	0.781650443638825	NA	NA	NA	NA	p.Lys344Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	30.9	63.9	38.8	0.841	3.4	-157.4	-98.2	136.3	18.695652173913	-5.3	0	1	23.32	0	0	0	0	7	27.8549173012594	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.897	-4.289	2.392	1.465	NA	87.84	0.003880524	0	0.110911849	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345A	345	L	A	missense	possibly_wt-like	0.863269789863234	0.255564204905889	6	0.104333649756586	0.65877959396471	1.06775998576176	1.00311679083957	0.461311748110184	0.719300375964745	0.793967139737417	1.04216820696714	1.15975447756035	NA	NA	0.708126436646487	0.784372129929585	0.520880475622549	0.646834420078845	0.643892793549187	0.769418453214128	0.862953047277891	NA	NA	p.Leu345Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	96	3.8	1.8	2	191	121	70	4.9	8.1	-3.2	131	89	42	9.71	6	-3.71	-1.296	-3.128	1.832	4.621	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L345C	345	L	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu345Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	198	3.8	2.5	1.3	191	148	43	4.9	5.5	-0.6	131	121	10	9.71	5.07	-4.64	-1.296	-3.07	1.774	24.105	24.105	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L345D	345	L	D	missense	low	0.247755089004429	0.145419261417207	7	0.0549633145069457	0.140028972099868	0.355481205908991	0.434932473130818	0.155243028602018	0.254248418983016	0.433249895945714	0.116092719137856	NA	0.0715424488119619	0.268976638419621	0.423494227277755	0.514043373179509	0.379787946930851	0.418748542663545	0.485699690344553	0.423494227277755	NA	0.32611956251053	0.429262536872031	p.Leu345Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	172	3.8	-3.5	7.3	191	187	4	4.9	13	-8.1	131	133	-2	9.71	5.05	-4.66	-1.296	-4.069	2.773	1.6	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345E	345	L	E	missense	low	0.273958861738669	0.122561844856857	7	0.0463240231023608	0.183165444839041	0.364752278638298	0.095460356731137	0.36714324973774	0.341134669801025	0.373296993146654	0.170689202738787	NA	0.174779049642819	0.39520851037252	0.459407252422218	0.352530511388973	0.47747038268715	0.461362118320275	0.459407252422218	0.443888079157767	NA	0.381722113622264	0.492662249287508	p.Leu345Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	138	3.8	-3.5	7.3	191	214	-23	4.9	12.3	-7.4	131	147	-16	9.71	3.22	-6.49	-1.296	-3.903	2.607	2.34	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345F	345	L	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu345Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	22	3.8	2.8	1	191	228	-37	4.9	5.2	-0.3	131	165	-34	9.71	3.32	-6.39	-1.296	-3.825	2.529	4.101	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
L345G	345	L	G	missense	wt-like	0.779158371571151	0.0479521581432823	8	0.0169536480978223	0.745929831892853	0.812386911249449	0.822737983754982	0.811119948989705	0.7079040701283	0.853503720825251	0.759246543936794	0.755541171633537	0.739242015903185	0.783971517397452	0.676069411026843	0.698552129018837	0.682136169110261	0.64124507381984	0.670002652943426	0.663736509818986	0.663727347858611	0.685738137780163	0.687917714185892	p.Leu345Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	138	3.8	-9.4	13.2	191	97	94	4.9	9	-4.1	131	75	56	9.71	3.29	-6.42	-1.296	-3.788	2.492	2.525	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345H	345	L	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu345His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	99	3.8	-3.2	7	191	216	-25	4.9	10.4	-5.5	131	155	-24	9.71	7.59	-2.12	-1.296	-4.956	3.66	1.318	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345I	345	L	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu345Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	5	3.8	4.5	-0.7	191	191	0	4.9	5.2	-0.3	131	131	0	9.71	6.02	-3.69	-1.296	-2.33	1.034	13.947	13.947	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.81	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
L345K	345	L	K	missense	low	0.305155912901502	0.181479464315268	6	0.074088681061006	0.159944766359856	0.450367059443149	0.242387040197658	0.313218561949804	0.281703762406153	0.510224048095984	NA	NA	0.00716632813369674	0.476235736625717	0.442413046297647	0.422434777376258	0.452612009145625	0.43221408344967	0.519456823403122	NA	NA	0.291447009253444	0.53335801623449	p.Leu345Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	107	3.8	-3.9	7.7	191	230	-39	4.9	11.3	-6.4	131	146	-15	9.71	9.74	0.03	-1.296	-3.772	2.476	3.131	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345L	345	L	L	synonymous	wt-like	1.03644324967046	0.239766783761684	8	0.0847703593505876	0.870296398386788	1.20259010095413	1.12235823305256	0.836076791418843	0.869684395136808	0.764349353680511	1.53605073921855	1.08260907713894	1.01493239205433	1.06548501566313	0.827118753975879	0.841104408209478	0.693640853457442	0.720590632577585	0.630903867826805	0.953902261411047	0.824930186252334	0.834223152858025	0.829307321699423	p.Leu345=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	0	3.8	3.8	0	191	191	0	4.9	4.9	0	131	131	0	9.71	9.71	0	NA	NA	NA	NA	NA	NA	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
L345M	345	L	M	missense	wt-like	0.993474324194565	0.0548977602183877	3	0.0316952366399937	0.931352801898703	1.05559584649043	NA	1.01413692744926	1.03504250904878	0.931243536085655	NA	NA	NA	NA	0.775723579493902	NA	0.775723579493902	0.801690926712749	0.704095568738989	NA	NA	NA	NA	p.Leu345Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	15	3.8	1.9	1.9	191	203	-12	4.9	5.7	-0.8	131	149	-18	9.71	5.74	-3.97	-1.296	-2.695	1.399	13.947	13.947	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	2.15	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	B	0.5
L345N	345	L	N	missense	possibly_wt-like	0.719861098804889	0.137279448656823	7	0.0518867544665734	0.618164928775732	0.821557268834045	0.644132760771363	0.70411821428184	0.641231805100177	1.01777313450913	0.739899464259444	NA	0.666255917409897	0.625616395302373	0.63281017020194	0.613575957777551	0.63281017020194	0.60854549726736	0.742043257487587	0.656509643705507	NA	0.646428307358991	0.608384161803085	p.Leu345Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	153	3.8	-3.5	7.3	191	187	4	4.9	11.6	-6.7	131	132	-1	9.71	5.47	-4.24	-1.296	-4.173	2.877	1.824	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345P	345	L	P	missense	low	0.190994040937337	0.120759523677539	8	0.0426949390426227	0.107313498091663	0.27467458378301	0.114300416296684	0.280231403397867	0.30812528857061	0.351007679685177	0.0401507232219354	0.0579759946287113	0.123094875492286	0.253065946205425	0.408199220860314	0.361494169344176	0.437405484212512	0.445172586015671	0.449632239651252	0.395127019098155	0.319916522629415	0.353885358907905	0.421271422622473	p.Leu345Pro	1	0	NA	NA	NA	NA	NA	NA	NA	8.99	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	98	3.8	-1.6	5.4	191	154	37	4.9	8	-3.1	131	115	16	9.71	6.3	-3.41	-1.296	-2.848	1.552	19.765	19.765	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.15	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
L345Q	345	L	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Leu345Gln	1	0	yes	0.141500313990602	-2.038774246204	0.104989449205415	0.17801117877579	0.238233107	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	113	3.8	-3.5	7.3	191	214	-23	4.9	10.5	-5.6	131	146	-15	9.71	6.24	-3.47	-1.296	-4.177	2.881	2.549	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	4	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.5	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L345R	345	L	R	missense	low	0.232655303011966	0.16161740410141	8	0.0571403811989367	0.120662213799161	0.344648392224772	0.242452052784923	0.218518834247672	0.37207872332495	0.462920188813361	-0.0782446239614006	0.126783205088082	0.237214922096665	0.27951912170148	0.418907685421912	0.422465708838709	0.408957028429594	0.476538705565704	0.49871164300971	0.350901878310913	0.353829717538787	0.415349662005115	0.434557478615937	p.Leu345Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	102	3.8	-4.5	8.3	191	265	-74	4.9	10.5	-5.6	131	174	-43	9.71	6.34	-3.37	-1.296	-4.069	2.773	2.767	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
L345S	345	L	S	missense	possibly_wt-like	0.834954212781889	0.196304272921872	8	0.0694040412794752	0.698924791492586	0.970983634071191	0.733824432879991	0.999091797174781	0.966390988228639	0.905840308498179	0.683028414902987	0.450754677898662	0.932121149970944	1.00858193270093	0.730487781706181	0.656249149304089	0.768788027640276	0.768020619283482	0.692954944128881	0.635266155474396	0.513506408820859	0.789621565015051	0.800727858846304	p.Leu345Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	145	3.8	-0.8	4.6	191	143	48	4.9	9.2	-4.3	131	105	26	9.71	5.68	-4.03	-1.296	-3.642	2.346	2.949	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345T	345	L	T	missense	wt-like	0.801720296346692	0.0551514057790192	8	0.0194989665091577	0.76350302425299	0.839937568440394	0.861516412644367	0.726090885587856	0.725479941204771	0.785689621504228	0.817840320844395	0.849348851887043	0.858645361301014	0.789150975799864	0.688071294530886	0.717001994922672	0.642939201883646	0.649865203066974	0.640262675170656	0.685623501957133	0.70996259156627	0.750047990700179	0.690519087104638	p.Leu345Thr	0	0	NA	0.499116899121583	-0.745800678497552	0.34551871279716	0.652715085446005	NA	NA	5.264	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	92	3.8	-0.7	4.5	191	163	28	4.9	8.6	-3.7	131	119	12	9.71	5.6	-4.11	-1.296	-3.492	2.196	3.478	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345V	345	L	V	missense	wt-like	0.86335645331447	0.146292891243965	8	0.051722347718997	0.761982514589378	0.964730392039561	1.16693104185218	0.839382596562557	0.849324382478148	0.895344240162186	0.66681966518416	0.923588726992309	0.765364612316691	0.800096360967524	0.697911990575699	0.862311104015957	0.695164773993452	0.710605014235978	0.688351877183521	0.629211574315981	0.746553398513443	0.699807595613561	0.696016385537836	p.Leu345Val	1	0	NA	NA	NA	NA	NA	NA	NA	5.483	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	32	3.8	4.2	-0.4	191	165	26	4.9	5.9	-1	131	117	14	9.71	5.61	-4.1	-1.296	-2.244	0.948	12.159	12.159	39.95	0.003609954	0	0.103178509	0	NA	NA	Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Feb 16, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	1.81	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.5
L345W	345	L	W	missense	low	0.307126287122237	0.175248502583389	7	0.0662377079245869	0.177302765171563	0.436949809072911	NA	0.298083837026852	0.192821843342781	0.3095327316289	0.105375702809566	0.325443492263915	0.663957565075747	0.254668837707898	0.431443337259709	NA	0.445635155666889	0.388621727387998	0.431443337259709	0.419491016279912	0.451743947672038	0.645190429977289	0.422076471765116	p.Leu345Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	61	3.8	-0.9	4.7	191	264	-73	4.9	5.4	-0.5	131	204	-73	9.71	5.89	-3.82	-1.296	-5.247	3.951	0.685	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
L345X	345	L	X	nonsense	possibly_low	0.575647760800722	0.459528741730091	4	0.229764370865045	0.125317868974729	1.02597765262671	NA	0.448779211906695	0.349360633831786	0.250309751602091	NA	1.25414144586232	NA	NA	0.490249874992019	NA	0.515103187349798	0.46539656263424	0.405471008094107	NA	0.909473806244268	NA	NA	p.Leu345Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	NA	3.8	NA	NA	191	NA	NA	4.9	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
L345Y	345	L	Y	missense	low	0.169947387840614	0.292451437692092	4	0.146225718846046	-0.116649754711116	0.456544530392344	NA	0.358923336596915	0.460173393462111	NA	-0.174112265717006	NA	0.0348050870204352	NA	0.394386414368582	NA	0.473681141066742	0.519744953453045	NA	0.315091687670421	NA	0.306333062177471	NA	p.Leu345Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	34.7	64	38.8	0.926	4.2	-152.8	-112.6	137.4	1.57068062827225	-6.7	0	1	25.16	0	0	0	0	6	27.4520854919986	36	3.8	-1.3	5.1	191	255	-64	4.9	6.2	-1.3	131	181	-50	9.71	5.66	-4.05	-1.296	-4.085	2.789	1.969	NA	39.95	0.003609954	0	0.103178509	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.85	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
Y346A	346	Y	A	missense	low	0.392016988505603	0.192109650465699	7	0.0726106227982547	0.249702782926001	0.534331194085205	0.429556356394109	0.443877467983401	0.42226679328243	0.597269781962792	0.294574704739409	0.0147246074090654	NA	0.541849207768017	0.511485543073534	0.511485543073534	0.512843565895348	0.501153568056181	0.557630864145867	0.490164000448758	0.29859909506495	NA	0.56631225462648	p.Tyr346Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-2.286	-2.62	0.334	13.081	13.081	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y346C	346	Y	C	missense	low	0.524993218379736	0.121424229929042	5	0.0543025664473804	0.418562143874778	0.631424292884695	0.439379599500982	0.404027743482068	0.598469570247293	0.698212514140819	NA	NA	NA	0.48487666452752	0.53769790548355	0.516159211482834	0.494473513553522	0.587572653888825	0.601899454916142	NA	NA	NA	0.53769790548355	p.Tyr346Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-2.286	-3.234	0.948	42.453	42.453	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	medium	2.125	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	B	0.5
Y346D	346	Y	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr346Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-2.286	-3.854	1.568	4.28	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.78	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	T	T	D	B	0.571428571428571
Y346E	346	Y	E	missense	low	0.285186737728275	0.16321549255526	5	0.0729921872669344	0.142124679532281	0.42824879592427	0.0140531933417827	0.354061166978734	0.423074110977326	0.377436382553203	NA	NA	NA	0.25730883479033	0.461222588026115	0.313798894581352	0.471439762700931	0.501549519007529	0.461222588026115	NA	NA	NA	0.423402405170163	p.Tyr346Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-2.286	-3.724	1.438	3.306	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y346F	346	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr346Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-2.286	-2.285	-0.001	35.007	35.007	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.09	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	T	B	0.214285714285714
Y346G	346	Y	G	missense	low	0.222964415264023	0.0956752626749714	8	0.0338263135146382	0.156666059045572	0.289262771482475	0.260145165990106	0.143713110323544	0.274543341402294	0.35099797985183	0.174413909824687	0.0537384265260437	0.223415868699842	0.30274751949384	0.429792956992117	0.43088367664726	0.374472848647914	0.428702237336974	0.449627985774388	0.445279398151157	0.317827941039665	0.407917583017474	0.446223896273574	p.Tyr346Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-2.286	-3.566	1.28	3.539	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y346H	346	Y	H	missense	possibly_low	0.626843569672063	0.390537990847893	4	0.195268995423946	0.244123371343812	1.00956376800031	NA	NA	0.831094043348235	1.01809660928494	0.12239112034187	NA	NA	0.535792505713208	0.632467093654173	NA	NA	0.701663899520514	0.742185117849062	0.425846918380985	NA	NA	0.563270287787833	p.Tyr346His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-2.286	-4.556	2.27	1.645	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.78	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	D	0.571428571428571
Y346I	346	Y	I	missense	low	0.533742443902108	0.0791771129093484	4	0.0395885564546742	0.456150299051016	0.6113345887532	NA	0.5411087465611	0.592629003185686	0.581518532944313	NA	NA	NA	0.419713492917333	0.554194339286507	NA	0.55766554896013	0.584708133392028	0.550723129612885	NA	NA	NA	0.504969829156616	p.Tyr346Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-2.286	-2.4	0.114	14.823	14.823	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y346K	346	Y	K	missense	low	0.145718222818553	0.17313808032252	5	0.0774297034189947	-0.00604120721629481	0.2974776528534	0.360431585186709	NA	NA	NA	-0.0270244524457595	0.28935708396806	-0.00234840506107243	0.108175302444826	0.370034549909217	0.478597600061513	NA	NA	NA	0.370034549909217	0.433957942543416	0.286322436819647	0.348500378321214	p.Tyr346Lys	0	0	NA	NA	NA	NA	NA	NA	NA	8.604	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-2.286	-3.743	1.457	2.893	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y346L	346	Y	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr346Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-2.286	-2.386	0.1	32.147	32.147	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.085	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
Y346M	346	Y	M	missense	possibly_low	0.62562033334535	0.130430009652342	4	0.0652150048261712	0.497801272634448	0.753439394056251	NA	0.572385409773778	0.781169359547188	NA	0.477580833116079	NA	NA	0.671345730944353	0.601717598052162	NA	0.572083564328726	0.677178215419005	NA	0.558523712083824	NA	NA	0.631351631775598	p.Tyr346Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-2.286	-4.399	2.113	4.267	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y346N	346	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr346Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-2.286	-2.981	0.695	16.268	16.268	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	low	1.78	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	B	0.5
Y346P	346	Y	P	missense	low	0.291963716716002	0.14883303463839	5	0.0665601565498042	0.161508207073038	0.422419226358966	0.105106413418189	0.477406126227751	0.179759381763967	0.337458022740034	NA	NA	NA	0.360088639430071	0.443690016715139	0.357119878660261	0.528299713073462	0.382215210942515	0.443690016715139	NA	NA	NA	0.475023362345779	p.Tyr346Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-2.286	-4.132	1.846	1.488	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
Y346Q	346	Y	Q	missense	low	0.310389045142126	0.179603955437148	3	0.103694392019159	0.107151771385797	0.513626318898456	NA	NA	NA	NA	0.256946788772175	NA	0.163571921825494	0.51064842482871	0.47610855046047	NA	NA	NA	NA	0.47610855046047	NA	0.375686028626599	0.550641722019407	p.Tyr346Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-2.286	-3.085	0.799	6.848	6.848	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y346R	346	Y	R	missense	low	0.228649491190684	0.196336183694825	6	0.0801539113496114	0.0715507117254296	0.385748270655939	NA	0.305562383464981	0.359864997268899	0.467234633021649	0.0500070218024814	-0.0551180244843847	NA	0.24434593607048	0.432987227094852	NA	0.449082639714228	0.470548453547231	0.500603749166704	0.398808719458312	0.264175569208097	NA	0.416891814475476	p.Tyr346Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-2.286	-4.041	1.755	2.323	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.78	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y346S	346	Y	S	missense	low	0.513751858999666	0.168820793316169	7	0.0638082621787456	0.388689963213235	0.638813754786097	0.386377721648197	0.371912673131501	0.542301434086391	0.694379883310743	0.358283460880787	0.7855576284272	NA	0.457450211512843	0.52392302274747	0.490942162545015	0.479669006604381	0.560024853203955	0.600218648758736	0.513961630818215	0.678521639662278	NA	0.52392302274747	p.Tyr346Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-2.286	-2.594	0.308	11.242	11.242	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	1.78	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
Y346T	346	Y	T	missense	low	0.456285235785251	0.30616365700607	7	0.115718985274877	0.229480192318971	0.683090279251531	0.607423933444947	0.121971078217319	0.608700895552706	0.654784360187655	0.819039611122538	-0.0244532520573937	NA	0.406530024028986	0.582853971068226	0.596110759700771	0.364450137755756	0.592590632577813	0.582853971068226	0.686071482242317	0.27928939808192	NA	0.498348457523377	p.Tyr346Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-2.286	-3.531	1.245	4.198	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.125	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Y346V	346	Y	V	missense	low	0.488865566943974	0.231714993967779	7	0.0875800355833679	0.317211851435836	0.660519282452111	NA	0.754387303481462	0.662270190089018	0.534395781491771	0.0540406311624204	0.364354230462429	0.448434394522312	0.604176437398405	0.530057374337479	NA	0.655983374316364	0.618863824988684	0.530057374337479	0.400315425136093	0.470921987877184	0.529111074302896	0.597615984604393	p.Tyr346Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-2.286	-2.462	0.176	10.823	10.823	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.32	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Y346W	346	Y	W	missense	low	0.624152916669611	0.0533262346436464	2	0.0377073421316674	0.550247884138813	0.698057949200408	NA	NA	NA	NA	0.586445574537943	NA	0.661860258801278	NA	0.621624822887007	NA	NA	NA	NA	0.599188811099017	NA	0.644060834674997	NA	p.Tyr346Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-2.286	-4.998	2.712	1.626	NA	86.35	0.002719995	0	0.077741973	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.125	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
Y346X	346	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr346Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	36.9	61.7	40.9	0.936	20	163.8	-117.4	124.7	10.1960784313725	-6	0	1	28.93	0	0	0	0	7	30.5534164678846	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	1	0	2	0	1	1	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F347A	347	F	A	missense	low	0.337742865846048	0.215523503994274	8	0.0761990655897186	0.188395441634594	0.487090290057501	0.47809235018742	0.337386430932579	0.404251202040097	0.751115283848271	0.0845512666357776	0.162641370533662	0.149658572578979	0.334246450011595	0.46289858146736	0.534577829239906	0.463752990012107	0.492317776970961	0.62510004610544	0.411712301630133	0.371503227999824	0.36819239064948	0.462044172922612	p.Phe347Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.225	-3.228	2.003	2.88	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347C	347	F	C	missense	possibly_low	0.476020089452938	0.305761150911681	6	0.124826467149957	0.231364709521651	0.720675469384226	0.686527344793174	0.631644630928301	0.582002188512524	0.686962339544991	-0.0999279241363179	NA	NA	0.368911957074959	0.58823092973855	0.633746305381948	0.599401067974404	0.579496185968801	0.596965673508298	0.342802345467931	NA	NA	0.479454856488915	p.Phe347Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.225	-4.834	3.609	0.773	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F347D	347	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe347Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.225	-3.957	2.732	0.839	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347E	347	F	E	missense	low	0.24280525331759	0.14605435731187	3	0.0843245225103262	0.0775322261838138	0.408078280451367	NA	0.401423300072757	0.113876559218958	0.213115900661056	NA	NA	NA	NA	0.389159587440509	NA	0.493272908973464	0.34990281839975	0.389159587440509	NA	NA	NA	NA	p.Phe347Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.225	-3.837	2.612	1.227	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.575	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347G	347	F	G	missense	low	0.278923049647174	0.120283320592647	8	0.0425265758273482	0.19557249263976	0.362273606654588	0.356111409103221	0.241587960652381	0.247978889092365	0.344180027954364	0.0120063834100008	0.377743166601144	0.285347026469044	0.36642953389487	0.443955628933882	0.47654216172365	0.419591507458942	0.415673636290994	0.446637962461882	0.384614043544991	0.47752102884789	0.441273295405882	0.478208064270149	p.Phe347Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.225	-3.621	2.396	1.324	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347H	347	F	H	missense	low	0.295662718471855	0.105122078222801	6	0.0429159087244669	0.211549083008092	0.379776353935619	0.247231102907034	0.201714079876962	0.332529918123952	0.33351634914542	0.469135371469365	NA	NA	0.189849489308399	0.433350429177275	0.424739468669263	0.401210319481302	0.457141896672476	0.441961389685288	0.555369012687058	NA	NA	0.38952107997769	p.Phe347His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.225	-4.47	3.245	2.07	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347I	347	F	I	missense	low	0.391825682548386	0.0323474511337197	4	0.0161737255668598	0.360125762941506	0.423525602155266	NA	0.384632618765092	0.417415635036061	0.416266978033422	NA	NA	NA	0.34898749835897	0.481892246495162	NA	0.485532687470391	0.498774305549073	0.478251805519933	NA	NA	NA	0.469447835812717	p.Phe347Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.225	-3.224	1.999	6.804	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F347K	347	F	K	missense	low	0.331731595604186	0.0938638043194246	6	0.0383197376498396	0.256626289913476	0.406836901294895	0.441221036702246	0.241702749329834	0.296767416113693	0.232396650876547	0.44516455918344	NA	NA	0.333137161419353	0.450544562192418	0.51703532406415	0.419644423107404	0.439602089502292	0.397615190163131	0.546415007539473	NA	NA	0.461487034882544	p.Phe347Lys	0	0	NA	NA	NA	NA	NA	NA	NA	15.265	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.225	-3.823	2.598	1.642	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347L	347	F	L	missense	possibly_low	0.606929307356398	0.18947288767266	6	0.077351982481615	0.45532220755966	0.758536407153137	0.974162384792477	0.463858121837174	0.603069450971602	0.489463386962543	0.605858068417608	NA	NA	0.505164431156985	0.56885803678494	0.770596303414854	0.522054311056345	0.589828676716508	0.510352203466585	0.606440111891524	NA	NA	0.547887396853371	p.Phe347Leu	1	0	NA	NA	NA	NA	NA	NA	NA	7.276	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.225	-2.869	1.644	8.908	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	2	0	0	0	0	0.00109004905220735	0.00101156966636311	0.00101156966636311	0.00155138082455054	0.000943946107382896	0.000822476815116702	0.000238055838609754	deleterious	deleterious	medium	2.375	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.928571428571429
F347M	347	F	M	missense	low	0.447090641383855	0.323763459522757	7	0.122371085358163	0.207247721332778	0.686933561434931	0.232487625601418	0.745076648914044	0.797603280327336	0.5569727759241	-0.00992594764616476	0.133039179139492	NA	0.674380927426757	0.539958550041589	0.417724868360911	0.651691319254995	0.685238272331443	0.539958550041589	0.376421488247617	0.356913116297973	NA	0.632876053311395	p.Phe347Met	0	0	NA	NA	NA	NA	NA	NA	NA	6.223	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.225	-2.902	1.677	7.315	7.315	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.03	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
F347N	347	F	N	missense	low	0.257321303728654	0.140391595010384	4	0.0701957975051918	0.119740068752411	0.394902538704896	NA	0.281376916952047	0.413865419133126	0.261192921996039	NA	NA	NA	0.0728499568334027	0.424088692963044	NA	0.437933546682501	0.497033093417659	0.410243839243586	NA	NA	NA	0.330758292126237	p.Phe347Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.225	-4.108	2.883	0.957	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347P	347	F	P	missense	low	0.418394353692584	0.169905712736012	2	0.120141481637968	0.182921376632887	0.65386733075228	0.538535835330551	NA	NA	NA	NA	NA	NA	0.298252872054616	0.503650944259762	0.563335420189046	NA	NA	NA	NA	NA	NA	0.443966468330479	p.Phe347Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.225	-4.202	2.977	0.738	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347Q	347	F	Q	missense	low	0.152298571389066	0.0925587606074922	7	0.034983923175398	0.0837313419273696	0.220865800850762	NA	0.0583717721126513	0.220630797321405	0.110778349099721	0.0954785572520436	0.285022070162895	0.0604267505047731	0.235381703269972	0.402260697341769	NA	0.335131927989777	0.402260697341769	0.34427929647998	0.415794058028711	0.431821332628149	0.320132720844939	0.412389545969234	p.Phe347Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.225	-4.2	2.975	1.337	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347R	347	F	R	missense	low	0.290893077765346	0.143408220111041	8	0.0507024624592051	0.19151807741781	0.390268078112882	0.0161762252784635	0.345708292007723	0.170756030878294	0.377740091766682	0.304907168200011	0.346227261036901	0.490876306593873	0.274753246360821	0.46167173993247	0.314808983325614	0.467589227914497	0.377799495331373	0.461355780169764	0.4940235664038	0.461987699695175	0.55197000772618	0.432163826986351	p.Phe347Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.225	-4.111	2.886	1.451	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347S	347	F	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe347Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.225	-3.622	2.397	1.547	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	1	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F347T	347	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe347Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.225	-3.572	2.347	2.069	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347V	347	F	V	missense	low	0.354694323000546	0.142882368019105	8	0.0505165456691506	0.255683712865638	0.453704933135454	0.601113883944677	0.368160003278213	0.355057088110091	0.497571028694824	0.132285738816765	0.270741628487584	0.320358498902956	0.292266713769257	0.464160322897843	0.593108586315701	0.477939088957794	0.468190402661612	0.513907822243827	0.429542932671231	0.424782892925486	0.460130243134074	0.440959931962968	p.Phe347Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.225	-2.242	1.017	11.157	11.157	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.375	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	1
F347W	347	F	W	missense	low	0.443512880142118	0.133841134317396	6	0.0546404142788211	0.336419636055281	0.550606124228955	NA	0.293624232900571	0.562733014570649	0.611888631086605	0.308559846039328	NA	0.385918826003914	0.498352730251642	0.519953417727635	NA	0.443579353217844	0.57004557216185	0.564041982959781	0.495387979748896	NA	0.495440602146238	0.544466233309031	p.Phe347Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.225	-4.574	3.349	1.207	NA	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.925	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
F347X	347	F	X	nonsense	low	0.0881342666313141	0.179058665051707	6	0.0731003939001007	-0.0551398726685747	0.231408405931203	NA	0.203228203767021	0.150606158093422	0.167277581393455	-0.25759720632494	0.050778854565555	NA	0.214512008293372	0.368487031243842	NA	0.401908305112581	0.3679169406083	0.369057121879384	0.283906904316704	0.316369248846299	NA	0.401907782217771	p.Phe347Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F347Y	347	F	Y	missense	possibly_low	0.435061533388402	0.315670129646746	3	0.182252234326673	0.0778537180061685	0.792269348770635	0.417984284872363	NA	NA	NA	0.758923652550518	0.128276662742323	NA	NA	0.505979823168924	0.505979823168924	NA	NA	NA	0.663615897671999	0.35456580203021	NA	NA	p.Phe347Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	40.4	62.5	42.2	0.822	19	-157.2	-129.7	166.8	1.75438596491228	-6.7	0	1	30.48	0	0	0	0	8	30.9906475869737	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.225	-2.477	1.252	13.94	13.94	43.92	0.002012725	0	0.057527031	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.575	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
T348A	348	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.76	-2.106	0.346	14.807	14.807	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T348C	348	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.76	-4.811	3.051	1.61	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T348D	348	T	D	missense	low	0.280842001572572	0.159389069796035	6	0.0650703152628566	0.153306527194706	0.408377475950438	NA	0.251983575207978	0.519232773979372	0.404908557105123	0.0913547112388913	0.146820935263834	0.270751456640235	NA	0.428897964373056	NA	0.424383710815464	0.548710772051703	0.473270552516155	0.414253645547516	0.363705767511674	0.433412217930648	NA	p.Thr348Asp	0	0	NA	NA	NA	NA	NA	NA	NA	3.913	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.76	-3.553	1.793	4.327	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	1.75	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T348E	348	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.76	-2.706	0.946	12.31	12.31	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.495	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T348F	348	T	F	missense	low	0.286906652742366	0.221475891369663	5	0.0990470296959849	0.0927780417625662	0.481035263722165	0.557628443012988	NA	NA	NA	-0.046080644724379	0.223261607899956	0.344475439176909	0.355248418346354	0.472592370711198	0.572419234608148	NA	NA	NA	0.362916341242742	0.401381287457989	0.473119467822304	0.472592370711198	p.Thr348Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.76	-4.137	2.377	1.843	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T348G	348	T	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.76	-3.337	1.577	5.919	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	1.495	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T348H	348	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.76	-3.114	1.354	14.407	14.407	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T348I	348	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.76	-2.826	1.066	10.646	10.646	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.714285714285714
T348K	348	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.76	-2.724	0.964	13.819	13.819	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	medium	1.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.5
T348L	348	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.76	-3.244	1.484	6.571	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.955	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T348M	348	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.76	-4.545	2.785	1.448	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T348N	348	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.76	-3.631	1.871	4.857	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T348P	348	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.76	-3.833	2.073	2.572	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.785714285714286
T348Q	348	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.76	-3.888	2.128	2.922	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T348R	348	T	R	missense	low	0.664444225731293	0.0219015425613444	3	0.0126448614934603	0.639660752614614	0.689227698847973	NA	0.655731285875427	0.689361363835806	NA	NA	NA	NA	0.648240027482647	0.619746837107132	NA	0.610504610537249	0.632150757860336	NA	NA	NA	NA	0.619746837107132	p.Thr348Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.76	-3.772	2.012	5.346	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
T348S	348	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.76	-2.078	0.318	19.427	19.427	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.71	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
T348V	348	T	V	missense	low	0.112771759282194	0.168957005962094	2	0.119470644644772	-0.121386401431343	0.346929919995731	NA	NA	NA	NA	-0.00669888536257812	NA	0.232242403926967	NA	0.395149207327761	NA	NA	NA	NA	0.377626918082624	NA	0.412671496572899	NA	p.Thr348Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.76	-2.63	0.87	12.292	12.292	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	1.955	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T348W	348	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.76	-5.354	3.594	0.443	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
T348X	348	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T348Y	348	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr348Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	42.9	61.2	44.9	0.95	34.3	-98.9	-138.7	157.5	18.4049079754601	-3.7	0	1	34.71	0	0	0	0	7	34.068697624946	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.76	-4.143	2.383	2.362	NA	88.34	0.001766181	0	0.05048038	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.3	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K349A	349	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.539	-3.102	1.563	3.988	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K349C	349	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.539	-5.1	3.561	0.998	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K349D	349	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.539	-3.436	1.897	2.897	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K349E	349	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.539	-2.415	0.876	9.509	9.509	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
K349F	349	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.539	-4.316	2.777	1.474	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K349G	349	K	G	missense	wt-like	0.999502331682917	0.121358455268343	4	0.0606792276341716	0.880573230910233	1.1184314324556	NA	NA	NA	NA	1.03529183385376	0.826344551533152	1.02644861731433	1.10992432403043	0.80363779171676	NA	NA	NA	NA	0.766849867739447	0.698624400169659	0.840425715694074	0.851626877979799	p.Lys349Gly	0	0	NA	NA	NA	NA	NA	NA	NA	0.896	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.539	-3.407	1.868	2.724	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K349H	349	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.539	-4.402	2.863	1.962	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K349I	349	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.539	-4.003	2.464	2.891	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
K349L	349	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.539	-3.402	1.863	3.827	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K349M	349	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.539	-4.511	2.972	1.27	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K349N	349	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.539	-3.497	1.958	3.13	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
K349P	349	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.539	-3.757	2.218	1.515	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K349Q	349	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.539	-2.389	0.85	10.67	10.67	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
K349R	349	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.539	-1.941	0.402	28.087	28.087	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	1.545	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K349S	349	K	S	missense	wt-like	0.881351910244738	0.10563605487734	7	0.0399266758124875	0.803097063629856	0.95960675685962	0.979891275051944	0.882397437510797	0.913408557438253	0.762287708621961	0.911980085264563	NA	1.00146612712306	0.718032180702586	0.720788265051351	0.773321974879432	0.714993891749788	0.742035255641855	0.629999730208957	0.720788265051351	NA	0.826970311539164	0.654799810453294	p.Lys349Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.539	-3.236	1.697	5.042	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K349T	349	K	T	missense	possibly_low	0.69083530432878	0.223759523652942	2	0.158221876530067	0.380726124763505	1.00094448389405	NA	NA	NA	NA	0.532613427798713	NA	NA	0.849057180858847	0.649843665072796	NA	NA	NA	NA	0.579080467949896	NA	NA	0.720606862195696	p.Lys349Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.539	-2.565	1.026	13.424	13.424	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	medium	2.44	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.428571428571429
K349V	349	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.539	-3.571	2.032	3.905	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
K349W	349	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.539	-5.309	3.77	0.42	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	1
K349X	349	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K349Y	349	K	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys349Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	45.9	63.1	46.5	0.699	18.1	-148	-86.1	119.9	53.9130434782609	-0.7	0	1	57.99	0	0	0	0	5	34.4325505569948	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.539	-4.174	2.635	1.465	NA	81.64	0.003023235	0	0.086409093	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.44	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T350A	350	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.695	-2.443	0.748	25.372	25.372	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
T350C	350	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.695	-4.802	3.107	1.877	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350D	350	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.695	-2.696	1.001	12.699	12.699	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T350E	350	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.695	-3.527	1.832	3.526	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350F	350	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.695	-4.074	2.379	2.375	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350G	350	T	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.695	-2.536	0.841	24.544	24.544	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	1.83	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T350H	350	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.695	-4.721	3.026	1.645	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350I	350	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.695	-3.409	1.714	8.963	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T350K	350	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.695	-3.596	1.901	3.95	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T350L	350	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.695	-2.5	0.805	15.282	15.282	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T350M	350	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.695	-3.066	1.371	8.079	8.079	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T350N	350	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.695	-2.749	1.054	16.268	16.268	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350P	350	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.695	-3.869	2.174	2.546	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T350Q	350	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.695	-3.995	2.3	2.271	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T350R	350	T	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.695	-3.895	2.2	2.77	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T350S	350	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.695	-3.237	1.542	7.379	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.642857142857143
T350V	350	T	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.695	-2.168	0.473	14.697	14.697	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	medium	2.175	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
T350W	350	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.695	-5.284	3.589	0.475	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T350X	350	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T350Y	350	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr350Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	49.2	62.3	45	0.937	360	360	-46.1	-54	44.1717791411043	-1.8	0	0	74.25	1	1	0	0	4	35.2907914031409	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.695	-4.203	2.508	1.534	NA	87.59	0.003417946	0	0.09769058	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	medium	2.52	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V351A	351	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.839	-3.104	1.265	3.891	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
V351C	351	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.839	-4.926	3.087	1.381	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V351D	351	V	D	missense	possibly_wt-like	0.963744743312759	0.420973236128088	4	0.210486618064044	0.551198552679595	1.37629093394592	NA	0.970175347456784	1.26557329255307	1.25289934070065	0.36633099254053	NA	NA	NA	0.800308124281154	NA	0.755458030971375	0.914755317126393	0.845158217590933	0.516967688312103	NA	NA	NA	p.Val351Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.839	-2.427	0.588	21.657	21.657	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
V351E	351	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.839	-2.671	0.832	14.816	14.816	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
V351F	351	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.839	-4.054	2.215	4.768	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351G	351	V	G	missense	wt-like	1.13328306328096	0.171011662998848	2	0.120923506568474	0.896277345522457	1.37028878103946	1.25420656984943	NA	NA	NA	NA	NA	NA	1.01235955671248	0.853229957037089	0.903834750908122	NA	NA	NA	NA	NA	NA	0.802625163166056	p.Val351Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.839	-2.588	0.749	23.026	23.026	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	D	D	D	B	0.5
V351H	351	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.839	-4.743	2.904	1.255	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V351I	351	V	I	missense	wt-like	1.19004665068005	0.246246024690644	4	0.123123012345322	0.948729980815135	1.43136332054496	NA	0.888710409626171	1.34625270664956	1.43020659192364	NA	NA	NA	1.09501689452082	0.883528118178058	NA	0.717904065650438	0.954324734429745	0.922916585881871	NA	NA	NA	0.844139650474245	p.Val351Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.839	-2.393	0.554	13.947	13.947	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V351K	351	V	K	missense	possibly_wt-like	0.801015628225409	0.118675618586208	3	0.0685174003369925	0.666723991250591	0.935307265200227	NA	0.773039046857369	0.698827821462333	0.931180016356525	NA	NA	NA	NA	0.664581514112043	NA	0.664581514112043	0.636793605312854	0.704067712063882	NA	NA	NA	NA	p.Val351Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.839	-3.556	1.717	5.814	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351L	351	V	L	missense	possibly_wt-like	0.886054940683064	0.350511162982507	8	0.123924410113257	0.643167560055709	1.12894232131042	0.966024733754242	1.13802591532079	1.12006125536241	1.17439021600304	0.807902653127063	0.0873543935610892	0.960351067995023	0.834329290340848	0.785775306238392	0.766724600132188	0.832834317905653	0.843388580186886	0.810727919956016	0.681911407146386	0.334396333138625	0.804826012344595	0.713209807799829	p.Val351Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.839	-2.264	0.425	32.706	32.706	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V351M	351	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.839	-4.354	2.515	4.341	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351N	351	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.839	-3.832	1.993	3.787	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351P	351	V	P	missense	wt-like	1.16268186693299	0.176275239638276	4	0.088137619819138	0.989935306404399	1.33542842746159	NA	1.11845880586633	1.24564296865562	1.34780042434817	NA	NA	NA	0.938825268861855	0.855295721919846	NA	0.823814209752969	0.904980440695759	0.886777234086722	NA	NA	NA	0.765692709972727	p.Val351Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.839	-2.768	0.929	20.133	20.133	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351Q	351	V	Q	missense	wt-like	1.18551940244244	0.11184766821483	7	0.042274444974129	1.10266301282673	1.26837579205815	1.04623895401825	1.21141129269672	1.10702805032455	1.26521974868913	1.33572151419205	NA	1.26447088433261	1.06854537284377	0.850561351502571	0.804888642612434	0.866663741832418	0.836996412683951	0.850561351502571	0.879071717885745	NA	0.968622936070386	0.83084438014702	p.Val351Gln	0	0	NA	NA	NA	NA	NA	NA	NA	-0.521	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.839	-3.966	2.127	3.25	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351R	351	V	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.839	-2.875	1.036	16.562	16.562	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V351S	351	V	S	missense	wt-like	0.99098835857265	0.126780793958542	8	0.0448237795661498	0.903135364972034	1.07884135217327	0.770650524154317	1.07749046172755	1.00617514641075	0.979309862014567	1.18646075616444	0.882456339745272	0.961763762681906	1.0636000156824	0.796230675104983	0.673770138813793	0.804928492584152	0.787532857625814	0.72517513005525	0.823317178583116	0.726280368165552	0.805586880369119	0.828360584121725	p.Val351Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.839	-3.503	1.664	2.854	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351T	351	V	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.839	-3.46	1.621	2.927	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V351W	351	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.839	-5.399	3.56	0.645	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
V351X	351	V	X	nonsense	possibly_wt-like	0.825244670428357	0.620957118979134	2	0.439082989656207	-0.0353421755219816	1.6858315163787	NA	NA	NA	NA	1.26432766008456	NA	NA	0.38616168077215	0.670260954708	NA	NA	NA	NA	0.852403412716977	NA	NA	0.488118496699023	p.Val351Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V351Y	351	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val351Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	50.8	62.8	48.4	0.288	360	360	-69.2	360	96.3636363636364	-0.8	0	0	81.48	0	0	0	0	3	37.6250185097629	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.839	-4.18	2.341	1.946	NA	87.1	0.003062178	0	0.087522142	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E352A	352	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.382	-2.309	0.927	14.447	14.447	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
E352C	352	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.382	-4.955	3.573	1.09	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E352D	352	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.382	-3.125	1.743	3.433	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E352F	352	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.382	-4.138	2.756	3.439	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E352G	352	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.382	-3.325	1.943	3.908	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E352H	352	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.382	-4.412	3.03	1.667	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E352I	352	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.382	-3.746	2.364	7.247	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E352K	352	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.382	-2.386	1.004	22.62	22.62	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E352L	352	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.382	-3.241	1.859	14.243	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E352M	352	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.382	-2.905	1.523	11.696	11.696	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E352N	352	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.382	-3.551	2.169	3.426	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E352P	352	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.382	-3.69	2.308	2.214	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E352Q	352	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.382	-3.444	2.062	4.347	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E352R	352	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.382	-3.498	2.116	8.751	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E352S	352	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.382	-3.135	1.753	4.354	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E352T	352	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.382	-2.461	1.079	8.238	8.238	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E352V	352	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.382	-3.311	1.929	6.681	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	0.895	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
E352W	352	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.382	-5.238	3.856	0.574	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E352X	352	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E352Y	352	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu352Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.382	-4.143	2.761	1.651	NA	81.64	0.003096218	0	0.08849506	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.895	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E353A	353	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.651	-3.168	1.517	3.54	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
E353C	353	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.651	-5.096	3.445	0.791	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E353D	353	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.651	-1.795	0.144	34.75	34.75	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	neutral	neutral	0.255	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
E353F	353	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.651	-4.178	2.527	2.731	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E353G	353	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.651	-3.382	1.731	4.12	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Dec 16, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E353H	353	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.651	-4.436	2.785	1.671	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E353I	353	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.651	-3.749	2.098	5.74	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E353K	353	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.651	-2.462	0.811	13.819	13.819	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
E353L	353	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.651	-2.288	0.637	18.729	18.729	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E353M	353	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.651	-4.495	2.844	2.486	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E353N	353	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.651	-3.493	1.842	6.077	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E353P	353	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.651	-3.749	2.098	2.021	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E353Q	353	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.651	-2.624	0.973	11.679	11.679	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
E353R	353	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.651	-3.588	1.937	5.346	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E353S	353	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.651	-3.255	1.604	4.579	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E353T	353	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.651	-3.454	1.803	3.097	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E353V	353	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.651	-3.463	1.812	4.78	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E353W	353	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.651	-5.342	3.691	0.369	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E353X	353	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E353Y	353	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu353Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.651	-4.182	2.531	1.114	NA	87.59	0.002673424	0	0.076410922	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P354A	354	P	A	missense	wt-like	1.06832778101133	0.100616091389638	8	0.0355731602590491	0.998605668087318	1.13804989393533	1.14027525433508	0.964197403018086	1.0991657538759	0.909942993736508	1.22627959258202	1.07239221816726	1.11100791427469	1.02336111810107	0.826517452759441	0.849628906223609	0.752702299191304	0.833140330031103	0.694754183063235	0.838191020236918	0.819894575487778	0.885968794344195	0.80815067599706	p.Pro354Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.627	-2.39	0.763	26.019	26.019	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P354C	354	P	C	missense	wt-like	1.13104194965018	0.0082495805045371	2	0.00583333431670252	1.11960882447967	1.1424750748207	NA	NA	NA	NA	NA	1.12520861533348	NA	1.13687528396689	0.855544640237787	NA	NA	NA	NA	NA	0.845926335234333	NA	0.865162945241241	p.Pro354Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.627	-4.916	3.289	1.925	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P354D	354	P	D	missense	possibly_wt-like	0.961723050537503	0.299743695974616	4	0.149871847987308	0.667979626185917	1.25546647488909	NA	1.11282556944411	1.07516841453109	1.14476184021677	0.514136377958037	NA	NA	NA	0.809475866329355	NA	0.82121738256721	0.82137077585996	0.7977343500915	0.572178590891573	NA	NA	NA	p.Pro354Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.627	-3.576	1.949	4.376	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P354E	354	P	E	missense	possibly_low	0.660650020380836	0.305500118248447	7	0.115468191198031	0.434336524272711	0.886963516488962	NA	1.07258791117091	1.04876554406065	0.576696274239705	0.319766045240445	0.361481845461052	0.732198434968199	0.513054087524893	0.551849961434279	NA	0.802668499285307	0.808421423025025	0.548608320625882	0.499573919054364	0.469506267754887	0.681944511626306	0.551849961434279	p.Pro354Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.627	-3.514	1.887	4.611	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P354F	354	P	F	missense	wt-like	1.09648693847985	0.190520599365941	5	0.0852034022592495	0.929491338691444	1.26348253826826	1.1511758522299	0.939612249933824	1.12125908529231	1.37392137527737	NA	0.896466129665857	NA	NA	0.84397605882546	0.854815154743497	0.741368957376743	0.84397605882546	0.898232617374503	NA	0.733185411009815	NA	NA	p.Pro354Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.627	-4.268	2.641	3.361	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P354G	354	P	G	missense	wt-like	0.886169101191283	0.225262717881706	8	0.0796423976813332	0.730072870093453	1.04226533228911	0.408067351058685	0.85289317633556	0.983746777568126	1.08784920842518	0.736674722528515	0.959303130753137	0.975588490263624	1.08522995259743	0.768465640235689	0.501261578921291	0.701392923891707	0.776532808900797	0.772775227705178	0.655305080684699	0.7641560527662	0.813032787303112	0.839224177909586	p.Pro354Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.627	-2.205	0.578	42.636	42.636	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.145	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P354H	354	P	H	missense	wt-like	0.907497728108398	0.276810388242913	8	0.0978672513147224	0.715681440265612	1.09931401595118	0.576351266795575	0.992225612691059	1.08723769819704	0.969987913622806	1.14076056162216	0.377383620418016	1.09389722270581	1.02213792881472	0.785934629670048	0.581327114530648	0.765622832148137	0.827290185752543	0.721086975220995	0.806246427191959	0.477343818353438	0.87675308891745	0.807536331554689	p.Pro354His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.627	-4.684	3.057	2.058	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P354I	354	P	I	missense	possibly_wt-like	1.02948476811416	0.511454668636691	6	0.208800494120691	0.620243319683436	1.43872621654488	1.35910327878225	0.301078465938736	0.563174382895882	1.03139518768765	1.65945922740996	1.26269806597046	NA	NA	0.830854180258782	0.953742141924005	0.447015629196984	0.570262042343758	0.748017229903426	1	0.913691130614137	NA	NA	p.Pro354Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.627	-2.824	1.197	20.348	20.348	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P354K	354	P	K	missense	possibly_wt-like	1.18432003966278	0.666204333352211	2	0.471077601769211	0.261024906271619	2.10761517305393	NA	NA	NA	NA	1.65539764143199	NA	0.713242437893564	NA	0.835108890421697	NA	NA	NA	NA	0.998482843997095	NA	0.6717349368463	NA	p.Pro354Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.627	-3.467	1.84	10.34	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P354L	354	P	L	missense	possibly_wt-like	0.734344246245763	0.128898150154351	5	0.0576450051838206	0.62136211219685	0.847326380294676	0.595244006554152	0.61920549740217	0.728547787269027	0.862091687278653	NA	NA	NA	0.866632252724816	0.651369835723253	0.590315836484704	0.593666836763989	0.651369835723253	0.673768918867395	NA	NA	NA	0.72943390789141	p.Pro354Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.627	-3.37	1.743	12.559	NA	13.9	0.003079205	0	0.088008811	8.338e-06	2	239868	PTEN hamartoma tumor syndrome|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jun 25, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.5
P354M	354	P	M	missense	possibly_wt-like	0.765497854352606	0.289804506964897	6	0.118312194537142	0.533610214127911	0.9973854945773	NA	0.958139485288958	0.787073985837113	0.479576576317644	0.350161144424411	1.07792835593021	0.940107578317301	NA	0.714991927496163	NA	0.74990970107026	0.680074153922065	0.506016327420647	0.510927638373853	0.822623186599122	0.793923002555174	NA	p.Pro354Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.627	-4.622	2.995	2.767	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P354N	354	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro354Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.627	-3.707	2.08	4.912	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P354P	354	P	P	synonymous	wt-like	0.903426553459997	0.244168242083182	7	0.0922869209445594	0.722547512164566	1.08430559475543	1.08805981837682	1.05799387070499	0.970827958764116	0.835234131052586	0.716122487924127	1.17718446751225	NA	0.478563139885092	0.770196742407913	0.824786027872654	0.79594089224178	0.770196742407913	0.661990496191412	0.647628043617828	0.87154381331187	NA	0.534526949999286	p.Pro354=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P354Q	354	P	Q	missense	wt-like	1.19604795349684	0.0623594073343524	7	0.0235696405302962	1.14985230692891	1.24224360006478	NA	1.12911423367927	1.19217084640522	1.31469526910761	1.18367801625195	1.13151130904333	1.21368983204003	1.20747616795049	0.872258917234092	NA	0.828726182648582	0.878754906671785	0.872258917234092	0.822277719961371	0.849032760837249	0.941272596821693	0.90062210204206	p.Pro354Gln	1	0	NA	0.981220456363635	-0.0288603034922432	0.87965999117204	1.08278092155523	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.627	-3.944	2.317	4.123	NA	13.9	0.003079205	0	0.088008811	7.755e-05	21	270810	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not specified|Hereditary cancer-predisposing syndrome|Inborn genetic diseases	Conflicting interpretations of pathogenicity(Last reviewed: Mar 29, 2017)	criteria provided, conflicting interpretations	0	0	1	0	0	0	0	0	0	1	1	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
P354R	354	P	R	missense	wt-like	0.952042265790708	0.183597119493742	8	0.064911384100171	0.824818290767727	1.07926624081369	1.0261712535509	0.792693417574803	0.848992404328377	0.799110680894811	1.33712833481149	0.865394840244517	1.05812138535634	0.888725809564429	0.729200787448514	0.795340901942562	0.673641848238389	0.710442194734982	0.646148501451021	0.879597218603781	0.717871221011463	0.85748445929598	0.740530353885566	p.Pro354Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.627	-2.806	1.179	29.453	29.453	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.571428571428571
P354S	354	P	S	missense	possibly_low	0.682472035688275	0.421763032680035	7	0.159411442381683	0.370031349896595	0.994912721479956	0.744268530106073	1.14103740167186	1.08973825558669	0.50533761576071	0.188101563842573	NA	0.119232748445513	0.989588134404508	0.661218205524946	0.661218205524946	0.834222562431505	0.828516590281507	0.517313870971486	0.450392254698219	NA	0.351805242798018	0.791188260557531	p.Pro354Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.627	-2.34	0.713	19.646	19.646	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
P354T	354	P	T	missense	possibly_wt-like	0.889416365236576	0.632659669645185	4	0.316329834822593	0.26942128174879	1.50941144872436	NA	1.15023414447883	1.17930604688509	1.28379148945969	NA	-0.0556662198773036	NA	NA	0.848584061564392	NA	0.838462106088395	0.872445334069692	0.85870601704039	NA	0.263905378670152	NA	NA	p.Pro354Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.627	-2.586	0.959	21.418	21.418	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P354V	354	P	V	missense	possibly_low	0.692163626062667	0.373170506548264	8	0.131935697859548	0.433574409982794	0.95075284214254	0.170486434852705	0.863112094956839	0.919590680200523	0.877535348893626	0.755173685147346	0.0764826803778624	0.732574444083423	1.14235363998901	0.681344394060973	0.38822615766134	0.706103673396223	0.745067292973066	0.680541760470515	0.66221514299457	0.329037962617279	0.682147027651431	0.867914438908719	p.Pro354Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.627	-3.375	1.748	13.21	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P354W	354	P	W	missense	possibly_wt-like	0.786021018868927	0.464722338659977	6	0.189722100298304	0.414172535212956	1.1578695025249	NA	0.896214100879179	1.11896751741566	1.16058065659472	0.00482139956484969	0.447143322703674	NA	1.08839911605548	0.763017428714187	NA	0.721363141034261	0.842852153717752	0.804671716394113	0.381930180287985	0.51172647047142	NA	0.840815884098599	p.Pro354Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.627	-5.406	3.779	0.489	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P354X	354	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro354Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P354Y	354	P	Y	missense	possibly_wt-like	0.873161874301751	0.195908609540056	3	0.113107888454517	0.651474486563524	1.09484926203998	NA	NA	1.05541744249068	0.665985116967467	NA	0.898083063447107	NA	NA	0.733982353512105	NA	NA	0.811683862989235	0.587766080216692	NA	0.733982353512105	NA	NA	p.Pro354Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.627	-4.312	2.685	1.611	NA	13.9	0.003079205	0	0.088008811	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S355A	355	S	A	missense	wt-like	1.02584474943808	0.255994067932951	6	0.104509140602517	0.821010597801917	1.23067890107425	NA	1.14303994119013	1.00989758390219	0.583794883943017	1.34669383323766	NA	1.12278236751224	0.948859886843246	0.812252117853478	NA	0.835145699447574	0.789358536259381	0.551721426851693	0.883170294106	NA	0.892310437062813	0.770732577356272	p.Ser355Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-2.077	-2.119	0.042	26.163	26.163	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	-0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S355C	355	S	C	missense	wt-like	1.15577453568136	0.317257115816778	8	0.112167328986865	0.935930610625053	1.37561846073767	1.18618026300978	1.17861721465025	1.07083883985449	1.13895234079591	1.65945922740996	1.17676962038351	1.32272830884603	0.512650470500967	0.861442785127231	0.871469431449077	0.851546223762866	0.81924732529896	0.795186585166844	1	0.871339346491596	1	0.551647245568254	p.Ser355Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-2.077	-4.885	2.808	1.935	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S355D	355	S	D	missense	wt-like	1.16079025969314	0.115708587548577	6	0.0472378330586948	1.06820580819039	1.2533747111959	1.06851410702306	1.30304562482403	1.20202749063981	1.22832446619622	1.17972222392504	NA	0.983107645550697	NA	0.827590475195557	0.815486637366128	0.90890562677771	0.883589122107	0.834380868502055	0.820800081889059	NA	0.817082554660829	NA	p.Ser355Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-2.077	-3.511	1.434	4.941	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355E	355	S	E	missense	possibly_wt-like	0.759828707540591	0.305168809223522	6	0.124584644668396	0.515647290963815	1.00401012411737	NA	0.955413535871456	0.652930135850757	0.271525900555944	0.732714070085101	NA	0.766149991305422	1.18023861157487	0.677028111361415	NA	0.748653084265318	0.614282972389189	0.414775382916287	0.653825627175026	NA	0.700230595547805	0.886942092275912	p.Ser355Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-2.077	-2.678	0.601	16.217	16.217	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355F	355	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-2.077	-2.971	0.894	33.668	33.668	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S355G	355	S	G	missense	wt-like	0.957178805757598	0.210010774160558	8	0.0742500212655837	0.811651438225721	1.10270617328948	0.473221719420965	1.01878859870376	1.15594548324199	1.12137578342902	0.993847835326191	0.980706498100891	0.9224640382387	0.991080489599271	0.781144115049166	0.532260497489192	0.77786792165665	0.860988088109407	0.787478358844488	0.751368966561552	0.774705188005593	0.784420308441682	0.791937793054403	p.Ser355Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-2.077	-3.292	1.215	7.078	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355H	355	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-2.077	-4.564	2.487	2.621	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S355I	355	S	I	missense	wt-like	0.961676049501803	0.11648468688161	7	0.0440270732908524	0.875384571507027	1.04796752749658	NA	0.910376983646009	1.15202848435064	0.84998776258557	0.862228239399831	1.09016341850122	0.96574262994429	0.901204828085057	0.746797916690389	NA	0.727891991634698	0.859066986358182	0.668460724038596	0.702204068626928	0.828653514800615	0.807729871987818	0.746797916690389	p.Ser355Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-2.077	-3.762	1.685	9.395	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S355K	355	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-2.077	-3.4	1.323	7.738	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355L	355	S	L	missense	possibly_wt-like	0.93211204439033	0.456907451991209	4	0.228453725995605	0.484350969304963	1.3798731194757	NA	0.442867933492444	0.661086069758869	NA	1.42286597931792	NA	1.20162819499209	NA	0.764953271167538	NA	0.512378187485037	0.618283070257062	NA	0.911623472078014	NA	0.934776278800257	NA	p.Ser355Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-2.077	-2.65	0.573	30.656	30.656	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
S355M	355	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-2.077	-4.529	2.452	4.069	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S355N	355	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-2.077	-2.777	0.7	10.61	10.61	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355P	355	S	P	missense	wt-like	0.929027513172395	0.0851019534037702	4	0.0425509767018851	0.845629131329697	1.01242589501509	NA	0.887051490722939	1.04236629176314	0.94116370898548	NA	NA	NA	0.845528561218017	0.717986975896121	NA	0.717139331954922	0.805282893978611	0.708446075853243	NA	NA	NA	0.718834619837319	p.Ser355Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-2.077	-2.804	0.727	23.816	23.816	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S355Q	355	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-2.077	-2.894	0.817	18.314	18.314	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S355R	355	S	R	missense	possibly_wt-like	0.919709850831519	0.471944414186369	5	0.211059958344408	0.506039933897957	1.33337976776508	NA	0.102700746250986	NA	NA	1.23279103846573	1.25208761717719	1.01579770127815	0.99517215098554	0.83468920268878	NA	0.355566839030464	NA	NA	0.840623291586986	0.908461530175467	0.83468920268878	0.793992822035418	p.Ser355Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-2.077	-2.848	0.771	17.159	17.159	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S355S	355	S	S	synonymous	possibly_wt-like	0.828456091321462	0.419751208574472	7	0.158651044343837	0.517505758297875	1.13940642434505	1.27261904637741	1.02959613582055	0.915421700300318	0.986182052912258	0.0824886881275985	NA	0.424683077459872	1.08820193825223	0.743022606515586	0.912594974894187	0.782850014381408	0.743022606515586	0.728188939964898	0.410941850534891	NA	0.516318771860673	0.840716851930038	p.Ser355=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S355T	355	S	T	missense	possibly_wt-like	0.850112496501139	0.204359860340136	4	0.102179930170068	0.649843513424988	1.05038147957729	NA	0.617865974907932	0.830315056188692	0.836142704922324	NA	NA	NA	1.11612624998561	0.681835398006137	NA	0.593049339437718	0.701281843349989	0.662388952662285	NA	NA	NA	0.85474178324023	p.Ser355Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-2.077	-2.415	0.338	20.076	20.076	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	1	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	-0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S355V	355	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-2.077	-3.447	1.37	7.824	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S355W	355	S	W	missense	wt-like	1.20895947567195	0.166356528854622	4	0.0831782644273109	1.04593307309787	1.37198587824603	NA	1.18906999488414	1.23856733911622	1.40621911519974	NA	NA	NA	1.00198145348771	0.878937480150301	NA	0.85636477953501	0.901510180765592	0.912396840994949	NA	NA	NA	0.797412780986424	p.Ser355Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-2.077	-5.297	3.22	1.564	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S355X	355	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S355Y	355	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser355Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-2.077	-4.108	2.031	7.809	NA	90.32	0.002344247	0	0.067002469	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N356A	356	N	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.671	-3.085	1.414	5.765	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N356C	356	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.671	-4.955	3.284	1.443	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N356D	356	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.671	-3.274	1.603	3.115	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 24, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
N356E	356	N	E	missense	wt-like	1.03309902500103	0.0654766578662622	4	0.0327383289331311	0.968933079378063	1.09726497062399	1.04098976821657	1.06671399569572	0.938834312032372	1.08585802405943	NA	NA	NA	NA	0.785931356919702	0.802391203264866	0.799960723106653	0.75450537958926	0.771901990732752	NA	NA	NA	NA	p.Asn356Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.671	-3.205	1.534	5.638	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N356F	356	N	F	missense	possibly_wt-like	0.79999236571088	0.769855472494752	3	0.444476264281952	-0.0711651042646522	1.67114983568641	1.22451875917425	NA	NA	-0.0886660220665842	NA	NA	NA	1.26412436002498	0.88970998769252	0.88970998769252	NA	NA	0.256812660120024	NA	NA	NA	0.929073546442087	p.Asn356Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.671	-4.182	2.511	2.647	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N356G	356	N	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.671	-3.139	1.468	3.389	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N356H	356	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.671	-2.775	1.104	30.308	30.308	42.43	0.003473752	0	0.099285626	4.162e-06	1	240276	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
N356I	356	N	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.671	-3.91	2.239	4.179	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N356K	356	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.671	-3.216	1.545	6.024	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	T	D	B	0.285714285714286
N356L	356	N	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.671	-3.432	1.761	5.154	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N356M	356	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.671	-4.57	2.899	1.565	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
N356P	356	N	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.671	-3.803	2.132	2.095	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N356Q	356	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.671	-2.653	0.982	11.679	11.679	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
N356R	356	N	R	missense	possibly_wt-like	0.83807237703928	0.248080713089752	6	0.101278527015947	0.639570111680757	1.0365746423978	0.665661042570267	1.05528190831506	1.04866615741233	0.763449549547342	0.460845072767677	NA	NA	1.03453053162301	0.712599990279287	0.623818608748862	0.794690723221154	0.808372678598632	0.630509257337419	0.552272272519703	NA	NA	0.813760492235902	p.Asn356Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.671	-2.575	0.904	17.159	17.159	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N356S	356	N	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.671	-2.387	0.716	9.332	9.332	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
N356T	356	N	T	missense	wt-like	1.05500087136034	0.227548034347537	8	0.0804503790664064	0.897321025847584	1.21268071687309	1.2937455354453	0.888461582773935	0.945026635163791	0.746982342206194	1.45680994163619	0.966672538799372	1.04914992316589	1.09315847169201	0.805497246976494	0.922646462318631	0.717789360659204	0.757542419716637	0.623287538178591	0.924302826023215	0.767788232733533	0.852652489035657	0.843206261219455	p.Asn356Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.671	-2.191	0.52	19.405	19.405	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
N356V	356	N	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.671	-3.57	1.899	5.644	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N356W	356	N	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.671	-5.314	3.643	0.495	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N356X	356	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N356Y	356	N	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn356Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.671	-4.002	2.331	4.969	NA	42.43	0.003473752	0	0.099285626	0	NA	NA	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Dec 14, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P357A	357	P	A	missense	possibly_wt-like	0.835857891568072	0.601451070808529	4	0.300725535404265	0.246446672944188	1.42526911019196	NA	1.09091721574284	1.16171744063821	1.15583153830342	-0.065034628412185	NA	NA	NA	0.806853491733473	NA	0.811118000218855	0.863818958826875	0.802588983248091	0.355836311351244	NA	NA	NA	p.Pro357Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.695	-2.83	1.135	9.895	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P357C	357	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.695	-2.37	0.675	40.415	40.415	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.205	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P357D	357	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.695	-3.452	1.757	4.437	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P357E	357	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.695	-3.451	1.756	4.675	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P357F	357	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.695	-4.183	2.488	1.89	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P357G	357	P	G	missense	possibly_wt-like	0.855357178236668	0.268754678897553	5	0.120190746257211	0.619787644297541	1.09092671217579	0.491253276847045	NA	1.09207205231021	NA	0.740337152988227	0.806708758545443	1.14641465049241	NA	0.688946454059848	0.540839489110989	NA	0.829661206631145	NA	0.656673137002431	0.688946454059848	0.905038628534795	NA	p.Pro357Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.695	-3.223	1.528	6.068	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P357H	357	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.695	-4.629	2.934	1.749	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P357I	357	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.695	-3.745	2.05	3.824	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P357K	357	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.695	-3.44	1.745	4.909	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P357L	357	P	L	missense	wt-like	1.04298497098369	0.208895436896887	8	0.0738556899943577	0.898230478541397	1.18773946342599	0.785876243618424	0.805780231789679	1.10249065404514	0.886655639225235	1.05138118346166	1.40337989971224	1.13938491666726	1.16893099934989	0.80381544197297	0.681014178617559	0.679674649346134	0.834771035506128	0.684541477851693	0.772859848439813	0.983029364442261	0.901252460342808	0.881262866006998	p.Pro357Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.695	-3.317	1.622	5.312	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
P357M	357	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.695	-4.532	2.837	1.432	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P357N	357	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.695	-3.602	1.907	4.98	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
P357Q	357	P	Q	missense	possibly_low	0.474383893996374	0.258829816246369	4	0.129414908123185	0.220735335012372	0.728032452980376	NA	0.496223738581795	0.512182507467261	0.758646290109587	NA	NA	NA	0.130483039826854	0.54111363357864	NA	0.536974315676559	0.545252951480722	0.628402780508177	NA	NA	NA	0.359704396076637	p.Pro357Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.695	-3.882	2.187	2.996	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
P357R	357	P	R	missense	wt-like	1.06078320397077	0.120439282499429	3	0.0695356521720506	0.924495830072044	1.19707057786949	NA	1.15382198662398	NA	NA	NA	1.10378174079704	NA	0.924745884491284	0.835365613943618	NA	0.840116040935506	NA	NA	NA	0.835365613943618	NA	0.758621366529335	p.Pro357Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.695	-3.847	2.152	3.586	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.5
P357S	357	P	S	missense	possibly_wt-like	0.740390100261407	0.295368689017037	7	0.111638870887751	0.521581934046698	0.959198266476115	0.730834485581628	0.745994143552743	0.451085236573964	0.264914736334722	0.910233698457561	NA	0.987975028855146	1.09169337247408	0.654826602586901	0.654826602586901	0.652114268842405	0.515287644529169	0.411876046657901	0.720135923517278	NA	0.819704095149259	0.842470417983987	p.Pro357Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.695	-1.916	0.221	19.919	19.919	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	-0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P357T	357	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.695	-2.332	0.637	17.757	17.757	85.11	0.00317153	0	0.090647611	0	NA	NA	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Sep 20, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
P357V	357	P	V	missense	wt-like	1.14050045252875	0.19132168714117	6	0.0781067517040446	0.987414032239412	1.29358687281809	1.08883104087722	1.14497641021919	1.23198483787999	1.35695533346925	0.796686828616073	NA	NA	1.22356826411079	0.863415256335714	0.82515295742916	0.83603837908005	0.89828177682596	0.890792133591378	0.677721872423578	NA	NA	0.908704326071077	p.Pro357Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.695	-3.379	1.684	5.165	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P357W	357	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.695	-5.282	3.587	0.49	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P357X	357	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P357Y	357	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro357Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.695	-4.214	2.519	1.63	NA	85.11	0.00317153	0	0.090647611	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E358A	358	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.576	-3.006	1.43	5.664	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
E358C	358	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.576	-5.016	3.44	1.357	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E358D	358	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.576	-2.038	0.462	33.175	33.175	85.61	0.002982858	0	0.085255042	4.175e-06	1	239512	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 9, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	1	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	-0.145	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
E358F	358	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.576	-4.138	2.562	4.687	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E358G	358	E	G	missense	wt-like	1.16739776687126	0.195379542851485	4	0.0976897714257427	0.975929333218859	1.35886620052367	1.03858982232392	1.45751947148678	1.06742324420952	NA	NA	NA	NA	1.10605852946484	0.833628714087573	0.801249365362608	0.980115470362524	0.817572138004546	NA	NA	NA	NA	0.849685290170599	p.Glu358Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.576	-2.268	0.692	36.816	36.816	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E358H	358	E	H	missense	possibly_wt-like	0.845866641160643	0.43476441208334	2	0.307424864002712	0.243324979763204	1.44840830255808	NA	NA	NA	NA	0.538441777157931	NA	NA	1.15329150516336	0.727332768674018	NA	NA	NA	NA	0.581257576908152	NA	NA	0.873407960439885	p.Glu358His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.576	-4.421	2.845	1.487	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E358I	358	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.576	-3.758	2.182	9.852	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E358K	358	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.576	-3.259	1.683	3.813	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E358L	358	E	L	missense	wt-like	1.09364517408692	0.162913409270344	6	0.0665091208282575	0.96328969262011	1.22400065555372	1.22968727126073	1.04320370694121	0.893814443265883	NA	1.11573308180785	NA	1.32272830884603	0.956704232399809	0.793010296204957	0.892169044380708	0.789122875658611	0.732425274098747	NA	0.796897716751302	NA	1	0.774672384670223	p.Glu358Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.576	-2.48	0.904	32.147	32.147	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E358M	358	E	M	missense	possibly_wt-like	1.0649886882659	0.428856829826321	2	0.303247572528357	0.470634367711118	1.65934300882067	NA	NA	NA	NA	0.761741115737538	1.36823626079425	NA	NA	0.815188175671611	NA	NA	NA	NA	0.664668326750279	0.965708024592943	NA	NA	p.Glu358Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.576	-4.552	2.976	4.267	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E358N	358	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.576	-3.424	1.848	5.801	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
E358P	358	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.576	-3.726	2.15	1.929	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E358Q	358	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.576	-3.541	1.965	2.57	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
E358R	358	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.576	-3.692	2.116	2.474	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E358S	358	E	S	missense	wt-like	1.02016064101344	0.0955165141509438	4	0.0477582570754719	0.926556177181112	1.11376510484577	NA	NA	NA	NA	1.11566375805526	1.0183239317733	1.05657194619841	0.890082928026804	0.795058807718673	NA	NA	NA	NA	0.796871821707358	0.793245793729988	0.856649941602836	0.741211963996366	p.Glu358Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.576	-2.393	0.817	10.969	10.969	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E358T	358	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.576	-3.369	1.793	4.097	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E358V	358	E	V	missense	wt-like	0.945935975493	0.160995959505876	7	0.0608507529912533	0.826670691198	1.065201259788	NA	0.910667671221543	1.00459890345197	0.977529041107714	0.883796477656885	1.09837673882701	1.11012576076922	0.636457235416662	0.728025993714876	NA	0.728025993714876	0.786759785385441	0.724394148301937	0.71026062149107	0.832701636083282	0.885493672294634	0.613828952686362	p.Glu358Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.576	-3.464	1.888	8.204	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
E358W	358	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.576	-5.291	3.715	0.634	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E358X	358	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E358Y	358	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu358Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.576	-4.191	2.615	1.913	NA	85.61	0.002982858	0	0.085255042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
A359C	359	A	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	195	1.8	2.5	-0.7	121	148	-27	8.1	5.5	2.6	89	121	-32	6	5.07	-0.93	-1.5	-4.648	3.148	1.523	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359D	359	A	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	1.8	-3.5	5.3	121	187	-66	8.1	13	-4.9	89	133	-44	6	5.05	-0.95	-1.5	-3.602	2.102	3.097	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
A359E	359	A	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	1.8	-3.5	5.3	121	214	-93	8.1	12.3	-4.2	89	147	-58	6	3.22	-2.78	-1.5	-3.503	2.003	3.347	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359F	359	A	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	1.8	2.8	-1	121	228	-107	8.1	5.2	2.9	89	165	-76	6	3.32	-2.68	-1.5	-4.117	2.617	2.884	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359G	359	A	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	60	1.8	-9.4	11.2	121	97	24	8.1	9	-0.9	89	75	14	6	3.29	-2.71	-1.5	-1.959	0.459	43.648	43.648	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
A359H	359	A	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	1.8	-3.2	5	121	216	-95	8.1	10.4	-2.3	89	155	-66	6	7.59	1.59	-1.5	-4.701	3.201	1.215	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359I	359	A	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	1.8	4.5	-2.7	121	191	-70	8.1	5.2	2.9	89	131	-42	6	6.02	0.02	-1.5	-3.508	2.008	13.404	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359K	359	A	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	1.8	-3.9	5.7	121	230	-109	8.1	11.3	-3.2	89	146	-57	6	9.74	3.74	-1.5	-3.52	2.02	3.833	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359L	359	A	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	1.8	3.8	-2	121	191	-70	8.1	4.9	3.2	89	131	-42	6	9.71	3.71	-1.5	-3.2	1.7	10.612	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
A359M	359	A	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	1.8	1.9	-0.0999999999999999	121	203	-82	8.1	5.7	2.4	89	149	-60	6	5.74	-0.26	-1.5	-4.498	2.998	2.589	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359N	359	A	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	1.8	-3.5	5.3	121	187	-66	8.1	11.6	-3.5	89	132	-43	6	5.47	-0.53	-1.5	-3.744	2.244	3.652	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359P	359	A	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	1.8	-1.6	3.4	121	154	-33	8.1	8	0.0999999999999996	89	115	-26	6	6.3	0.3	-1.5	-2.475	0.975	43.335	43.335	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
A359Q	359	A	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	1.8	-3.5	5.3	121	214	-93	8.1	10.5	-2.4	89	146	-57	6	6.24	0.24	-1.5	-3.962	2.462	2.254	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359R	359	A	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-4.5	6.3	121	265	-144	8.1	10.5	-2.4	89	174	-85	6	6.34	0.34	-1.5	-3.823	2.323	2.908	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359S	359	A	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	1.8	-0.8	2.6	121	143	-22	8.1	9.2	-1.1	89	105	-16	6	5.68	-0.32	-1.5	-3.095	1.595	7.678	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Oct 15, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
A359T	359	A	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	1.8	-0.7	2.5	121	163	-42	8.1	8.6	-0.5	89	119	-30	6	5.6	-0.4	-1.5	-2.397	0.897	20.442	20.442	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
A359V	359	A	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	1.8	4.2	-2.4	121	165	-44	8.1	5.9	2.2	89	117	-28	6	5.61	-0.39	-1.5	-2.396	0.896	21.979	21.979	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
A359W	359	A	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	148	1.8	-0.9	2.7	121	264	-143	8.1	5.4	2.7	89	204	-115	6	5.89	-0.11	-1.5	-5.262	3.762	0.47	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
A359X	359	A	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	1.8	NA	NA	121	NA	NA	8.1	NA	NA	89	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
A359Y	359	A	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ala359Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	1.8	-1.3	3.1	121	255	-134	8.1	6.2	1.9	89	181	-92	6	5.66	-0.34	-1.5	-4.191	2.691	1.734	NA	87.59	0.00345212	0	0.098667346	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360A	360	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.38	-2.754	1.374	3.738	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360C	360	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.38	-4.703	3.323	0.841	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S360D	360	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.38	-2.114	0.734	19.787	19.787	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360E	360	S	E	missense	wt-like	1.24241218539031	0.0929761087517923	6	0.0379573374519014	1.16801717103555	1.31680719974507	NA	1.30013203748274	1.19534183479658	1.27732075872713	1.27505063265852	1.33046415044024	1.07616369823662	NA	0.873756027771042	NA	0.907562512047765	0.88031012573636	0.855868268104895	0.856408848597888	0.947091182956408	0.867201929805723	NA	p.Ser360Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.38	-3.022	1.642	4.572	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360F	360	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.38	-4.062	2.682	1.438	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360G	360	S	G	missense	wt-like	0.978379891675762	0.284998553665138	6	0.116350172318466	0.750337744336539	1.20642203901499	1.20011475969006	1.01402307943614	1.00623932973727	1.17870406876873	0.421837126498363	NA	NA	1.04936098592401	0.800092051615648	0.878099137771681	0.775671097475866	0.787564336496345	0.81261976673495	0.537701329010326	NA	NA	0.821209059092498	p.Ser360Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.38	-2.861	1.481	5.482	NA	85.61	0.00360516	0	0.103041468	4.178e-06	1	239344	PTEN hamartoma tumor syndrome|Cowden syndrome 1|not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Oct 8, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S360H	360	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.38	-4.262	2.882	2.742	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360I	360	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.38	-3.781	2.401	1.907	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S360K	360	S	K	missense	wt-like	0.911621935127062	0.248297958307613	7	0.0938478069610039	0.727683613455427	1.0955602567987	0.902245175371953	0.997610188505405	0.531890649288039	0.637023816702267	1.24402442510359	NA	1.06780675402835	1.00075253688983	0.768105030978514	0.736379783870661	0.768105030978514	0.554918858164766	0.575065057350043	0.844819386428513	NA	0.862700934870413	0.796795560012968	p.Ser360Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.38	-3.185	1.805	4.679	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360L	360	S	L	missense	wt-like	1.09742995745493	0.176029314703182	7	0.0665328271659636	0.967028012420009	1.22783190248984	0.940912660441917	1.282319527018	1.09909372969872	0.805616036049497	1.2477718930176	1.07170381929064	1.23459203666811	NA	0.833105005596059	0.754776865310304	0.899351244500216	0.833105005596059	0.649001434980205	0.84621920745219	0.81955528248168	0.952530386131175	NA	p.Ser360Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.38	-3.388	2.008	2.625	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360M	360	S	M	missense	wt-like	0.941753963289774	0.176225096963514	3	0.101743607169853	0.742340157579671	1.14116776899988	0.745027859769546	NA	NA	NA	0.99506798681274	NA	1.08516604328703	NA	0.751824739297206	0.661579476748899	NA	NA	NA	0.751824739297206	NA	0.872050533370375	NA	p.Ser360Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.38	-4.51	3.13	1.015	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360N	360	S	N	missense	wt-like	1.30734284931409	0.133807780990822	6	0.0546267978402659	1.20027629295641	1.41440940567176	1.44515132884073	1.44550996816112	1.20412897752668	1.31779746812542	1.32503875822763	NA	1.10643059500294	NA	0.884061640976257	0.994681783635484	0.974579291444042	0.884619801525226	0.873619391394483	0.875081304429794	NA	0.883503480427289	NA	p.Ser360Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.38	-2.177	0.797	27.114	27.114	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S360P	360	S	P	missense	possibly_low	0.417336740446875	1.01122347016914	2	0.715042973051593	-0.984121734132692	1.81879521502644	NA	1.13237971349847	NA	NA	-0.297706232604718	NA	NA	NA	0.549578089830414	NA	0.830231513888647	NA	NA	0.268924665772181	NA	NA	NA	p.Ser360Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.38	-3.608	2.228	1.649	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360Q	360	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.38	-3.587	2.207	2.935	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S360R	360	S	R	missense	wt-like	0.903788582745596	0.235172923651649	6	0.0960089440441745	0.715614510225293	1.0919626552659	NA	1.2369281267256	0.754075972376802	0.550553075256331	0.901181252946281	1.03176946114776	0.948223608020804	NA	0.757524367608154	NA	0.87842657288267	0.663890196968299	0.537143180419654	0.716754492686342	0.79987272796103	0.798294242529965	NA	p.Ser360Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.38	-3.611	2.231	3.794	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00093504207689346	0.000866690123354582	0.000866690123354582	0.00139122286577568	0.000791779931602594	0.000543045589468079	0.000165477839033609	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S360S	360	S	S	synonymous	wt-like	1.03637143895943	0.0381181555548448	2	0.0269536062791544	0.983543341398819	1.08919953652005	NA	1.06332504523859	NA	NA	NA	NA	NA	1.00941783268028	0.799773080983603	NA	0.798398473980455	NA	NA	NA	NA	NA	0.801147687986752	p.Ser360=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S360T	360	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.38	-3.002	1.622	4.288	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Oct 31, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S360V	360	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.38	-3.524	2.144	2.304	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S360W	360	S	W	missense	wt-like	1.0820745924291	0.0850215640379362	7	0.0321351306460188	1.01909089372442	1.14505829113379	1.02538035919468	1.11204300133958	1.04036814670926	NA	0.949603236404425	1.20046308137321	1.08761549491868	1.15904882706388	0.820856631841295	0.794964612978974	0.820856631841295	0.804302898816834	NA	0.734841935196374	0.883017206344607	0.873369791835378	0.87629956417775	p.Ser360Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.38	-5.318	3.938	0.31	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S360X	360	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S360Y	360	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser360Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.38	-4.116	2.736	1.343	NA	85.61	0.00360516	0	0.103041468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.975	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S361A	361	S	A	missense	possibly_wt-like	0.911139310157716	0.357903767934183	3	0.206635836760782	0.506140512191286	1.31613810812415	NA	NA	NA	NA	0.555371031516144	1.27114101050927	0.906905888447737	NA	0.776040791758705	NA	NA	NA	NA	0.587581293804354	0.91785242740036	0.776040791758705	NA	p.Ser361Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.802	-2.875	1.073	6.563	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S361C	361	S	C	missense	possibly_wt-like	0.810689875661802	0.35305094279747	7	0.133440713539857	0.549150883052357	1.07222886827125	1.34485045572357	1.08325935185766	0.913757969758041	0.575402453230539	0.296324562693744	0.580833976052876	NA	0.88040036031618	0.736348913177267	0.946960983385224	0.80758785384626	0.742206625774465	0.548040913428267	0.490817638587665	0.577618942413294	NA	0.736348913177267	p.Ser361Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.802	-2.807	1.005	34.898	34.898	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S361D	361	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser361Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.802	-3.416	1.614	7.485	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S361E	361	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser361Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.802	-3.422	1.62	4.446	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S361F	361	S	F	missense	possibly_wt-like	0.796954234764223	0.435170154305088	7	0.164478858041267	0.474581596785064	1.11932687274338	0.0963028784566486	1.15024224022547	1.00809438562734	1.10317448729187	0.244727737442062	0.942468209614172	NA	1.03366970469201	0.779496152371584	0.3529313634426	0.838465838091346	0.788474153225399	0.779496152371584	0.471544272571035	0.755858579898778	NA	0.813328143582421	p.Ser361Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.802	-4.072	2.27	3.959	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S361G	361	S	G	missense	wt-like	1.07303251168917	0.194556096071723	8	0.0687859674267483	0.938214492891001	1.20785053048734	1.24152256885763	1.26185442298173	1.11430935966707	1.30040840412428	0.911904106764667	0.886380128925327	1.08889814460853	0.778982957584152	0.853280469678328	0.89780000107103	0.88991717595817	0.840567548780011	0.865993390576645	0.720759884207554	0.728214296693654	0.874060618483721	0.685412219712606	p.Ser361Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.802	-3.183	1.381	5.753	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
S361H	361	S	H	missense	wt-like	1.08740944210224	0.109515091507245	5	0.0489766378344621	0.991416995862833	1.18340188834165	0.893257005203705	NA	NA	NA	1.1396868707257	1.15822923802914	1.12116819579651	1.12470590075614	0.859050896169175	0.732103423557095	NA	NA	NA	0.805845363026958	0.862201298367274	0.891441054841732	0.859050896169175	p.Ser361His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.802	-4.525	2.723	2.877	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S361I	361	S	I	missense	wt-like	1.10522554140386	0.206833570259173	4	0.103416785129586	0.902532367152958	1.30791871565477	NA	0.851511945545023	1.09885695644133	1.35796108843346	NA	1.11257217519565	NA	NA	0.836343529280369	NA	0.700756199742774	0.832988879568957	0.89123320898101	NA	0.839698178991782	NA	NA	p.Ser361Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.802	-3.652	1.85	8.343	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S361K	361	S	K	missense	wt-like	1.10602250744783	0.154472840161137	5	0.0690823542555522	0.97062358113971	1.24142143375595	0.939113138065311	NA	NA	NA	1.27501754623768	1.08441467486962	1.25429697613064	0.977270201935889	0.825820116062884	0.753920694818352	NA	NA	NA	0.856396489568124	0.825820116062884	0.963143336332956	0.785001602909333	p.Ser361Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.802	-3.399	1.597	4.91	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S361L	361	S	L	missense	wt-like	0.912419787457253	0.225201329200367	7	0.0851181017121942	0.745591373668935	1.07924820124557	0.539402280315915	1.11138093556114	1.02195256804193	0.658406272340063	1.08828748522983	NA	1.04675929350458	0.920749677207305	0.786645748227801	0.563747654367966	0.820551430659711	0.795270932914123	0.584442366224779	0.786645748227801	NA	0.851364911695236	0.756614279185724	p.Ser361Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.802	-3.172	1.37	16.397	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S361M	361	S	M	missense	wt-like	1.01890602468178	0.198593946030267	7	0.0750614561541527	0.871788273992504	1.16602377537105	NA	0.959007390335924	1.15446378956868	1.23414679155271	1.07657695454676	0.762210735878786	1.19080538029766	0.755131130591914	0.782271422036163	NA	0.750309790690452	0.860261387798908	0.836934258260551	0.782271422036163	0.667014593929185	0.928947182313384	0.673432685950674	p.Ser361Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.802	-2.88	1.078	13.464	13.464	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S361N	361	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser361Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.802	-2.501	0.699	28.45	28.45	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
S361P	361	S	P	missense	wt-like	1.2468503806733	0.0837012928125351	3	0.0483249639368368	1.1521351918029	1.3415655695437	NA	1.34285643882094	1.18920193726397	1.208492765935	NA	NA	NA	NA	0.877298797873009	NA	0.927257742031845	0.877298797873009	0.82568364578775	NA	NA	NA	NA	p.Ser361Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.802	-2.515	0.713	43.09	43.09	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S361Q	361	S	Q	missense	wt-like	1.326397791274	0.311363845932596	3	0.179766000265101	0.974062905109579	1.67873267743841	NA	NA	NA	NA	1.65945922740996	1.04260666056294	1.27712748584909	NA	0.975439698023582	NA	NA	NA	NA	1	0.805214087588678	0.975439698023582	NA	p.Ser361Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.802	-3.812	2.01	3.079	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S361R	361	S	R	missense	wt-like	0.914542730248498	0.186073386207091	8	0.0657868765926888	0.785602821471447	1.04348263902555	0.918059306650692	0.937827148803095	0.771754746844134	0.787106902247083	1.11315847778117	1.05392895719961	1.1335527592509	0.60095354321131	0.742224915998595	0.743903776199248	0.740546055797942	0.672560795436863	0.640884225824758	0.795936004756194	0.810794538388786	0.898111298892068	0.595997292261118	p.Ser361Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.802	-3.753	1.951	3.981	NA	85.11	0.003826693	0	0.109373253	4.182e-06	1	239134	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	deleterious	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S361S	361	S	S	synonymous	wt-like	1.03154255069485	0.211931109747631	5	0.094778473588534	0.845780155951647	1.21730494543806	NA	1.27778348860735	1.05323663574311	1.17274190706038	0.74060053867603	NA	NA	0.913350183387398	0.81000505152883	NA	0.897260207132433	0.810614280950012	0.81000505152883	0.656771521520079	NA	NA	0.752897897792147	p.Ser361=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S361T	361	S	T	missense	possibly_wt-like	1.09395793712768	0.419284788910848	4	0.209642394455424	0.683066394362314	1.50484947989306	NA	0.686816422062178	NA	NA	1.65945922740996	1.1358242614219	NA	0.893731837616702	0.79710155951289	NA	0.624834335170208	NA	NA	1	0.851158497277845	NA	0.743044621747935	p.Ser361Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.802	-2.13	0.328	22.089	22.089	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S361V	361	S	V	missense	wt-like	0.920491862390174	0.14487661653543	7	0.0547582140201735	0.813167735052897	1.02781598972745	0.731570487570216	1.06885717020524	0.970448662372916	1.12683549292563	0.780556207906022	0.863839036200695	NA	0.901335979550492	0.746863787259072	0.655176775050904	0.800948690486859	0.770010715558895	0.789872722858768	0.671696475405375	0.717104407687297	NA	0.746863787259072	p.Ser361Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.802	-3.324	1.522	7.692	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S361W	361	S	W	missense	possibly_low	0.684783774065981	0.405661671837328	8	0.143423059511823	0.403679742870263	0.965887805261699	1.03950299892961	0.75109016514744	0.789873501266233	0.0527341194485368	0.522869567228539	1.0882005768235	0.162562532598955	1.07143673108504	0.667955316095693	0.801683833349164	0.654463449033765	0.681447183157622	0.318823910108305	0.575440767439875	0.827686083742906	0.375142378258333	0.832296559205689	p.Ser361Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.802	-5.233	3.431	0.661	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S361X	361	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser361Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S361Y	361	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser361Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.802	-4.161	2.359	1.901	NA	85.11	0.003826693	0	0.109373253	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S362A	362	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.517	-2.785	1.268	6.109	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
S362C	362	S	C	missense	wt-like	0.936853291147179	0.107546058817031	4	0.0537730294085156	0.831460090166876	1.04224649212748	NA	0.837781180559571	0.86508122588113	0.971589653071345	NA	NA	NA	1.07296110507667	0.720061208703179	NA	0.6944265481672	0.718332996881594	0.721789420524764	NA	NA	NA	0.833062173081077	p.Ser362Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.517	-4.719	3.202	1.529	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S362D	362	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.517	-3.248	1.731	4.156	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S362E	362	S	E	missense	wt-like	1.19858464992033	0.030753588129287	2	0.0217460707120369	1.15596313451947	1.24120616532118	1.22033072063237	1.17683857920829	NA	NA	NA	NA	NA	NA	0.869221860025993	0.887717417294213	0.850726302757773	NA	NA	NA	NA	NA	NA	p.Ser362Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.517	-3.259	1.742	3.367	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S362F	362	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.517	-4.121	2.604	1.91	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S362G	362	S	G	missense	possibly_wt-like	0.944931240074432	0.322021587881407	5	0.144012432145049	0.662672059744117	1.22719042040475	NA	1.08440988778047	1.09516190583886	1.30813731520947	0.500787181245475	NA	NA	0.736159910297891	0.808118231543659	NA	0.808118231543659	0.831176632902526	0.869382916444901	0.567192160951084	NA	NA	0.663904427419734	p.Ser362Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.517	-3.021	1.504	3.592	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
S362H	362	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.517	-4.41	2.893	1.598	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S362I	362	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.517	-3.754	2.237	4.429	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S362K	362	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.517	-3.276	1.759	3.856	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S362L	362	S	L	missense	possibly_wt-like	0.902850632125589	0.33372976853694	8	0.117991291208144	0.67159195086825	1.13410931338293	0.317398618030513	1.13286254588893	1.07210189756319	1.31636827552942	0.497698552521857	0.923184450231474	0.920918346303422	1.0422723709359	0.800618312483021	0.458123524751739	0.830454091494796	0.819866795062261	0.872992616778826	0.566038441287337	0.746354141538832	0.783587808977901	0.817648815988142	p.Ser362Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.517	-3.327	1.81	5.462	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
S362M	362	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.517	-4.508	2.991	1.659	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S362N	362	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.517	-2.351	0.834	15.797	15.797	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S362P	362	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.517	-2.381	0.864	39.039	39.039	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
S362Q	362	S	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.517	-3.719	2.202	2.267	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S362R	362	S	R	missense	wt-like	0.980827542180945	0.15386619756078	5	0.0688110554370635	0.845960351786112	1.11569473257578	NA	0.985570586968408	1.03407225296874	0.724185403368988	NA	1.13603300284446	NA	1.02427646475413	0.801215062229199	NA	0.762554977291143	0.801215062229199	0.613289905516742	NA	0.851261380224293	NA	0.808610407075008	p.Ser362Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.517	-3.665	2.148	2.925	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S362T	362	S	T	missense	wt-like	0.909884101864116	0.148464677673198	8	0.0524901901746966	0.807005219580052	1.01276298414818	0.746382839942147	0.962517253455052	0.886320353213359	1.04781690846814	0.770605829520299	1.15956972807478	0.760789288884376	0.945070613354774	0.740338778849225	0.662224144498543	0.751927778518921	0.728749779179528	0.755219000860973	0.66797963267917	0.862861989301965	0.69734335664259	0.768829422109376	p.Ser362Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.517	-2.002	0.485	20.564	20.564	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S362V	362	S	V	missense	wt-like	1.0866878041642	0.16264507901573	6	0.0663995754605316	0.956547027672805	1.21682858065559	1.15402133927596	NA	0.781997692442339	NA	1.18798563383231	1.24212984949673	1.08895240077515	1.06503990916268	0.84262636924458	0.856168970664728	NA	0.677584473327064	NA	0.823886778074561	0.903553618432568	0.874089840496588	0.829083767824432	p.Ser362Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.517	-3.4	1.883	5.981	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
S362W	362	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.517	-5.291	3.774	0.47	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S362X	362	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S362Y	362	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser362Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.517	-4.158	2.641	1.547	NA	12.16	0.003887182	0	0.111102146	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T363A	363	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.775	-2.24	0.465	25.516	25.516	86.1	0.003742973	0	0.106980392	8.449e-06	2	236718	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T363C	363	T	C	missense	wt-like	1.28110945186521	0.163004420643887	4	0.0815022103219437	1.1213680549738	1.44085084875663	NA	1.38948207393839	NA	NA	1.45042502419522	1.16154706289242	1.12298364643481	NA	0.907168331196708	NA	0.948751375132115	NA	NA	0.921917817832779	0.863836563632533	0.892418844560636	NA	p.Thr363Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.775	-4.703	2.928	1.888	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T363D	363	T	D	missense	possibly_low	0.68844152173105	0.0378901445613205	3	0.0218758851621123	0.645565574683376	0.731317468778724	NA	0.64868619058526	0.692498369088876	0.724140005519013	NA	NA	NA	NA	0.613269996219668	NA	0.607256940174329	0.633689309811061	0.613269996219668	NA	NA	NA	NA	p.Thr363Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.775	-2.448	0.673	19.787	19.787	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T363E	363	T	E	missense	wt-like	1.18596667292735	0.0544151580655721	8	0.0192386636337519	1.14825958509452	1.22367376076019	1.16017667625019	1.12530589627449	1.17646405789596	1.28074189588465	1.25509424090927	1.14892755842027	1.15205441581248	1.18896864197151	0.858357144989911	0.859097535462737	0.826970603197616	0.871051473572048	0.857368613078003	0.848954381376728	0.857616754517085	0.908076168873622	0.891326733079876	p.Thr363Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.775	-3.33	1.555	4.572	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T363F	363	T	F	missense	wt-like	1.16262157073961	0.0924939536094183	7	0.0349594284325237	1.09410235009176	1.23114079138746	NA	1.17707132394192	1.08547614124339	1.23096016391046	1.31207756366725	1.05982191568887	1.19227491740992	1.08066896931546	0.836933432918363	NA	0.850833594162984	0.826426225807082	0.835536757796791	0.870239807970342	0.813699016691349	0.929738665292656	0.836933432918363	p.Thr363Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.775	-4.072	2.297	3.238	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T363G	363	T	G	missense	wt-like	1.02351640299137	0.24849731017149	8	0.0878570665644385	0.851319716737728	1.195713089245	0.441538452941951	0.988809815509585	1.04940964471786	1.15354865491836	1.15662410499286	1.19974559892243	1.18447986918153	1.01397508274635	0.806086940877946	0.517186343257706	0.764048207133837	0.808737323778347	0.801587821221181	0.812172060721013	0.882663578839073	0.925540303819597	0.803436557977544	p.Thr363Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.775	-3.212	1.437	6.903	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T363H	363	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.775	-4.633	2.858	1.615	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T363I	363	T	I	missense	wt-like	1.07577894447233	0.103629114871894	6	0.0423064089887342	0.992859906539187	1.15869798240547	NA	1.05081228707774	1.10451590322796	1.25039753192658	1.10235587162202	NA	0.977897311712152	0.96869476126751	0.803453303166576	NA	0.792630303052504	0.835764323954684	0.844061045497259	0.791900822718865	NA	0.814276303280647	0.780694604496016	p.Thr363Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.775	-2.612	0.837	19.607	19.607	86.1	0.003742973	0	0.106980392	4.222e-06	1	236830	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T363K	363	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.775	-3.46	1.685	4.532	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T363L	363	T	L	missense	wt-like	0.871189794855209	0.2219645042531	8	0.0784763030700388	0.717379067198083	1.02500052251234	0.355046412812734	0.835938831824142	1.01225338906109	0.835565874265774	0.959255779230896	1.01273592782417	1.02870724585883	0.93001489796404	0.74985762169147	0.476035461495964	0.693577256406084	0.790513946700342	0.66213598268884	0.738447525074788	0.790491619191942	0.841642198105131	0.761267718308152	p.Thr363Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.775	-3.163	1.388	12.102	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T363M	363	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.775	-4.485	2.71	2.667	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T363N	363	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.775	-3.529	1.754	4.598	NA	86.1	0.003742973	0	0.106980392	4.222e-06	1	236830	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
T363P	363	T	P	missense	possibly_wt-like	0.879434899579169	0.463824286887406	4	0.231912143443703	0.424895450852025	1.33397434830631	NA	1.36916643262699	0.961464446352099	NA	0.250496259548861	0.936612459788729	NA	NA	0.759288412709889	NA	0.93938620639084	0.765604384689338	NA	0.47369903378739	0.752972440730441	NA	NA	p.Thr363Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.775	-2.499	0.724	39.039	39.039	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T363Q	363	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.775	-3.872	2.097	2.766	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T363R	363	T	R	missense	possibly_wt-like	0.922791520767022	0.364816285179425	8	0.128982034568828	0.669991378359418	1.17559166317463	1.01130923905545	1.02654050161924	1.14938046610282	1.30228675540767	0.218155695172022	1.19191190061885	0.537761634302281	0.94498597385784	0.784855661431126	0.788269904422674	0.781441418439579	0.857768259288233	0.866817144426904	0.461618609626044	0.878802562883672	0.577222135453325	0.768786912086498	p.Thr363Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.775	-3.814	2.039	3.311	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T363S	363	T	S	missense	wt-like	1.20399392750074	0.172403739477686	8	0.0609539266432953	1.08452642656359	1.3234614284379	1.08684161034739	1.22592359270528	1.12608295679768	1.26799732479319	1.55997280460646	1.0820731103629	1.27248818543388	1.01057183495917	0.849060700133544	0.824206433097165	0.873353667900753	0.846341938483259	0.851779461783829	0.962838057748243	0.824666022865684	0.972941001472324	0.801727283389058	p.Thr363Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.775	-2.142	0.367	18.391	18.391	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	neutral	neutral	neutral	-0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T363T	363	T	T	synonymous	wt-like	0.858076754493637	0.180579831772839	8	0.0638446117960501	0.732943614766438	0.983209894220836	0.620645161634697	0.900256841183425	0.744417917211364	1.16776640166185	0.719624444816862	1.00099570878833	0.959559424042265	0.751348136610301	0.697379730425439	0.602401109623939	0.723226776276982	0.659153380031045	0.807823035968021	0.648936156987961	0.784705185854753	0.80439963814212	0.671532684573896	p.Thr363=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T363V	363	T	V	missense	wt-like	0.954240478646156	0.133683415154636	7	0.0505275815589957	0.855208238564614	1.0532727187277	NA	0.799526375143776	1.0667105515053	1.11767079134518	1.01042303395188	0.791754360018836	0.862350529064832	1.0312477094933	0.75756043024857	NA	0.676791726682022	0.817222596112869	0.785853528855961	0.75756043024857	0.681575839430954	0.752043569577313	0.812111701199888	p.Thr363Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.775	-3.14	1.365	12.729	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T363W	363	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr363Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.775	-5.3	3.525	0.478	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T363X	363	T	X	nonsense	low	0.457907175515084	0.267822982776268	7	0.101227572544791	0.259504779084877	0.65630957194529	0.848634812340163	0.272056659576367	0.262504305532022	0.646411139399779	NA	0.707729403499202	0.17579780407852	0.292216104179531	0.440934513394865	0.710873231972598	0.433637064888134	0.422797662550262	0.57918188218684	NA	0.640162233085373	0.382270808030308	0.440934513394865	p.Thr363Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T363Y	363	T	Y	missense	wt-like	1.10658634450925	0.131808957041288	4	0.0659044785206438	0.977415940188891	1.2357567488296	NA	0.945167104697967	NA	NA	1.24408732233256	1.05992776505214	NA	1.17716318595432	0.829297033937271	NA	0.743929651937257	NA	NA	0.844842880922786	0.813751186951757	NA	0.885397465733652	p.Thr363Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.775	-4.187	2.412	1.543	NA	86.1	0.003742973	0	0.106980392	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S364A	364	S	A	missense	possibly_wt-like	0.733838875987859	0.377070330733406	6	0.153938317906556	0.432125317050332	1.03555243492539	0.409058383171287	1.01288076426738	0.85737154601118	1.00952815324527	NA	0.124764408779412	NA	0.989430000452625	0.726489586826335	0.501733088729903	0.775144509407728	0.714551765405564	0.738427408247106	NA	0.352834707971604	NA	0.791108838087457	p.Ser364Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.77	-2.17	0.4	23.575	23.575	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
S364C	364	S	C	missense	wt-like	1.07039058843541	0.226734483472073	3	0.130905215067172	0.813821081515278	1.32696009535553	NA	NA	0.82503394410489	NA	1.27218031184915	NA	NA	1.11395750935217	0.853652537471024	NA	NA	0.698691708924622	NA	0.855336675198182	NA	NA	0.853652537471024	p.Ser364Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.77	-2.763	0.993	42.573	42.573	88.09	0.003650357	0	0.104333268	4.257e-06	1	234880	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S364D	364	S	D	missense	wt-like	1.14967638730166	0.110293854692676	4	0.0551469273463379	1.04159039584479	1.25776237875853	NA	NA	NA	NA	1.27725803581436	1.15266498466639	1.00795861478427	1.16082391394162	0.858346113511012	NA	NA	NA	NA	0.857233397177402	0.859458829844622	0.830467122496897	0.877191098113038	p.Ser364Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.77	-3.478	1.708	3.19	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364E	364	S	E	missense	wt-like	1.13784462719693	0.0862855572869662	3	0.0498169897268068	1.04020512151418	1.23548413287967	NA	NA	NA	NA	1.17936566815126	1.03864814707832	1.19552006636121	NA	0.820666894819896	NA	NA	NA	NA	0.820666894819896	0.803263044399179	0.931486481076753	NA	p.Ser364Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.77	-3.38	1.61	3.447	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364F	364	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser364Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.77	-4.137	2.367	1.955	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
S364G	364	S	G	missense	wt-like	1.10947044215989	0.117889545921812	5	0.0527218077035508	1.00613759786108	1.2128032864587	NA	NA	0.929121031009037	NA	1.12335197711443	1.25985207153047	1.12554957561604	1.10947755552947	0.851402489368276	NA	NA	0.749741476994016	NA	0.799743662352993	0.912288417678819	0.893800837064263	0.851402489368276	p.Ser364Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.77	-3.136	1.366	6.378	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364H	364	S	H	missense	possibly_wt-like	0.803042491434891	0.522886200458494	6	0.213467397444325	0.384654080570517	1.22143090229927	1.1736260083076	1.11549788940202	1.24224510426463	NA	0.435509846943823	-0.0838791416981843	NA	0.935255241389456	0.79317447385262	0.86549641185	0.822449277093839	0.903313949738518	NA	0.542808607303186	0.25	NA	0.7638996706114	p.Ser364His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.77	-4.547	2.777	1.251	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S364I	364	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser364Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.77	-3.731	1.961	4.534	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S364K	364	S	K	missense	possibly_low	0.685513107263631	0.484051786403205	6	0.197613314295088	0.298198128379665	1.0728280861476	NA	0.921820261197062	0.941163363250973	1.20389874100253	0.112194000278409	0.0442606092277909	NA	0.889741668625021	0.737103858562659	NA	0.733167150000419	0.755647668494327	0.823668929073275	0.422037908304494	0.313156583732703	NA	0.741040567124899	p.Ser364Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.77	-3.296	1.526	6.024	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364L	364	S	L	missense	wt-like	1.0416301121527	0.097104687234928	5	0.043426536318231	0.956515664995648	1.12674455930975	NA	0.959565596394379	1.0637713692969	1.09477337525599	0.927450406041498	NA	NA	1.16258981377474	0.7758118317404	NA	0.750567114289038	0.81578106696151	0.7758118317404	0.72656701506696	NA	NA	0.878078017873021	p.Ser364Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.77	-3.278	1.508	5.596	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364M	364	S	M	missense	wt-like	1.00370969071216	0.208036624669933	8	0.073552054019635	0.859550313844733	1.14786906757959	0.645681827717386	1.15730588693453	1.19276450931011	1.28308249355107	0.98918533993909	0.900607222973303	1.01950543850524	0.84154480676657	0.79315675681261	0.61431296745661	0.841722060346164	0.879046070105286	0.858395085791957	0.749627348163364	0.735226442807728	0.836686165461857	0.716833786904651	p.Ser364Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.77	-4.499	2.729	1.698	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S364N	364	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser364Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.77	-3.521	1.751	3.761	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364P	364	S	P	missense	wt-like	1.09416141501805	0.302723732562598	7	0.114418816045408	0.869904656415338	1.31841817362077	NA	1.10575728480987	1.02377978586166	1.28712462001119	1.65491322131322	0.766072468487495	0.815462032658527	1.0060204919844	0.799441380223398	NA	0.817959022306935	0.796167096393032	0.860167766580795	0.998301894758274	0.668917936468037	0.726789735210416	0.799441380223398	p.Ser364Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.77	-2.47	0.7	39.039	39.039	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S364Q	364	S	Q	missense	possibly_wt-like	0.920235988198485	0.698429084698257	4	0.349214542349128	0.235788062316556	1.60468391408041	1.08828109145808	NA	NA	0.95504397439431	1.65945922740996	-0.0218403404684088	NA	NA	0.769712296024807	0.824891304408973	NA	NA	0.714533287640641	1	0.280577230845472	NA	NA	p.Ser364Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.77	-3.785	2.015	2.402	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S364R	364	S	R	missense	wt-like	1.10192381458715	0.119637466700665	2	0.0845964639880198	0.936117791951187	1.2677298372231	NA	1.01732735059913	NA	NA	NA	NA	NA	1.18652027857517	0.833645679096947	NA	0.777194310872577	NA	NA	NA	NA	NA	0.890097047321317	p.Ser364Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.77	-2.587	0.817	17.159	17.159	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S364T	364	S	T	missense	wt-like	1.1492930794693	0.188621182669022	7	0.0712921059058739	1.00956311951177	1.28902303942683	NA	1.2877807225121	1.19456641942129	1.29227677012273	1.06376423101851	1.32353592126129	0.78694136546558	1.09618612648358	0.862427249952738	NA	0.901868763713486	0.879929821356219	0.862427249952738	0.777485385123519	0.943676448004155	0.711428692299532	0.84472689495568	p.Ser364Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.77	-2.346	0.576	21.052	21.052	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
S364V	364	S	V	missense	possibly_wt-like	0.708761834337134	0.482983827663859	8	0.170760569872275	0.37407726740794	1.04344640126633	1.08165847355967	0.477755295179184	0.109111120189798	-0.0538165368631022	1.08300493846066	1.13993642876325	1.1251981935921	0.707246761815511	0.717027685978521	0.821740418319529	0.528460674083713	0.347565597093792	0.272095955566266	0.784672517183341	0.853185272257037	0.89361158502779	0.649382854773701	p.Ser364Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.77	-3.373	1.603	6.123	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S364W	364	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser364Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.77	-5.274	3.504	0.516	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S364X	364	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser364Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S364Y	364	S	Y	missense	wt-like	1.0335903057118	0.27751036417012	6	0.113293131758456	0.811539847769477	1.25564076365412	1.04186449785595	1.23524055863081	1.28102740872525	1.25579839834486	0.656257384973681	NA	NA	0.731353585740257	0.824618491438238	0.802807379087632	0.877648632391997	0.922334826456246	0.846429603788845	0.625266163111439	NA	NA	0.661490460249516	p.Ser364Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.77	-4.181	2.411	1.584	NA	88.09	0.003650357	0	0.104333268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
V365A	365	V	A	missense	possibly_wt-like	1.08185566976877	0.38403241930326	4	0.19201620965163	0.705510814403687	1.45820052513386	NA	0.506734930573262	1.28082138095111	1.29586748344648	NA	NA	NA	1.24399888410424	0.891483764040144	NA	0.5418197982859	0.922233779627112	0.8640019628149	NA	NA	NA	0.918965565265389	p.Val365Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.881	-2.951	1.07	8.892	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
V365C	365	V	C	missense	wt-like	0.951021328506148	0.107805506985528	3	0.0622415384782187	0.829030154746476	1.07301250226582	NA	0.906366867649167	1.073979129243	0.872717988626278	NA	NA	NA	NA	0.726043395648638	NA	0.726043395648638	0.820787487961997	0.678429099700722	NA	NA	NA	NA	p.Val365Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.881	-4.797	2.916	1.484	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V365D	365	V	D	missense	wt-like	0.824059132219489	0.0115989748218184	2	0.00820171375131978	0.807984068655396	0.840134195783583	NA	NA	NA	NA	0.832260845970809	NA	NA	0.81585741846817	0.69747122981463	NA	NA	NA	NA	0.691010113586001	NA	NA	0.703932346043258	p.Val365Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.881	-2.563	0.682	28.647	28.647	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365E	365	V	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.881	-3.462	1.581	6.619	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
V365F	365	V	F	missense	possibly_wt-like	0.923789981252913	0.259014799324344	3	0.149542264114007	0.630692529422883	1.21688743308294	NA	NA	NA	NA	0.657480315670947	0.939054874768969	NA	1.17483475331882	0.754176240371808	NA	NA	NA	NA	0.625722973987426	0.754176240371808	NA	0.884228014966697	p.Val365Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.881	-3.992	2.111	4.103	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V365G	365	V	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.881	-2.392	0.511	44.786	44.786	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
V365H	365	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.881	-4.719	2.838	1.572	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V365I	365	V	I	missense	wt-like	1.1409142543574	0.0537856817317152	4	0.0268928408658576	1.08820525481835	1.19362325389644	NA	1.06336612752343	1.15245100367094	1.18720789135622	NA	NA	NA	1.16063199487898	0.837811671618024	NA	0.798417412222371	0.859274211999208	0.81634913123684	NA	NA	NA	0.877094707136736	p.Val365Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.881	-3.249	1.368	8.624	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	PTEN hamartoma tumor syndrome|not specified	Uncertain significance(Last reviewed: Nov 21, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
V365K	365	V	K	missense	wt-like	0.949149288146063	0.247772319520343	8	0.0876007436615774	0.777454985550446	1.12084359074168	0.843019004459178	0.900066942610294	0.803447728629411	0.891244423448139	1.44393794268913	1.15139147821454	0.935882894500037	0.624203890617779	0.715670299339538	0.708201362448399	0.723139236230678	0.688104696392185	0.686553896244912	0.919494647499396	0.858831153293989	0.791647615764154	0.607674734069793	p.Val365Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.881	-3.548	1.667	4.411	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365L	365	V	L	missense	possibly_wt-like	0.916678762766264	0.31986487461282	7	0.120897558767197	0.679723901763744	1.15363362376878	NA	1.00712145542913	0.957398250338509	0.865677626457372	1.16339265766412	0.255901810789363	1.23887626921319	0.928383269472176	0.763610108842137	NA	0.772489564959922	0.763610108842137	0.675341538020896	0.81470037118197	0.417468752057699	0.954837845473549	0.760448236068424	p.Val365Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.881	-2.363	0.482	28.14	28.14	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
V365M	365	V	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.881	-2.902	1.021	13.545	13.545	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
V365N	365	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.881	-3.703	1.822	5.009	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365P	365	V	P	missense	wt-like	1.1127240533184	0.183371924258209	4	0.0916859621291044	0.933022869657447	1.29242523697934	NA	0.872707264071117	1.07856109943194	1.29731842734142	NA	NA	NA	1.2023094224291	0.843836501509868	NA	0.710526884875441	0.823034726523507	0.864638276496229	NA	NA	NA	0.898027114143109	p.Val365Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.881	-2.6	0.719	39.039	39.039	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V365Q	365	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.881	-3.933	2.052	2.692	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365R	365	V	R	missense	wt-like	0.917348498708865	0.0224280433428502	4	0.0112140216714251	0.89536942011102	0.93932757730671	NA	0.934855239703128	0.934754730913502	0.887847705654273	NA	NA	NA	0.911936318564555	0.745681921325419	NA	0.739176055718777	0.752504538984216	0.685064260421368	NA	NA	NA	0.752187786932062	p.Val365Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.881	-3.95	2.069	3.223	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365S	365	V	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.881	-2.288	0.407	17.899	17.899	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
V365T	365	V	T	missense	possibly_wt-like	0.814149137959165	0.266473531311801	6	0.108787363611911	0.600929823306755	1.02736845261157	NA	0.979225091301102	1.08751004292448	0.558296891559433	0.434523778828857	0.802951358108972	1.02238766503215	NA	0.723362172289894	NA	0.759629810580408	0.827423757894717	0.5405392429942	0.542440273561635	0.687094533999379	0.838238513626057	NA	p.Val365Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.881	-3.319	1.438	6.685	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V365V	365	V	V	synonymous	wt-like	1.07830389087176	0.208388008547035	7	0.0787632638319226	0.923930730456361	1.23267705128715	0.841585504373255	0.849832959763452	1.10357886701791	1.11394374235606	1.44495723195542	NA	1.00974330192187	1.18448562871432	0.831428343197582	0.707519336767733	0.69998221555406	0.835304752238168	0.78421902577763	0.919875390597642	NA	0.831428343197582	0.889075148382103	p.Val365=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V365W	365	V	W	missense	possibly_wt-like	0.809438126387436	0.522617887428827	5	0.233721824509638	0.351351767947555	1.26752448482732	NA	1.15908801889173	0.799918743945416	1.08477480965909	-0.0919965469510011	NA	NA	1.09540560639195	0.771426945388023	NA	0.84254359318594	0.686373897164377	0.771426945388023	0.345765014871773	NA	NA	0.844334880256238	p.Val365Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.881	-5.281	3.4	0.665	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V365X	365	V	X	nonsense	low	0.430412121122537	0.0997415776204829	2	0.0705279459016878	0.292179887251639	0.568644354993434	NA	0.500940067024224	NA	NA	NA	NA	NA	0.359884175220849	0.507034567154385	NA	0.539148463714792	NA	NA	NA	NA	NA	0.474920670593978	p.Val365Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V365Y	365	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val365Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.881	-4.136	2.255	1.912	NA	42.43	0.003499744	0	0.100028501	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T366A	366	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Ala	1	0	no	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.438	-2.793	1.355	5.657	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T366C	366	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.438	-4.586	3.148	1.519	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T366D	366	T	D	missense	wt-like	1.20981968678134	0.0912916438575438	5	0.0408268642886338	1.12980050317391	1.28983887038877	1.17590473190024	1.08219353371541	1.25442210857146	1.32775033514424	NA	NA	NA	1.20882772457537	0.87798423656501	0.866580575028346	0.807096529619929	0.909286191484664	0.87798423656501	NA	NA	NA	0.901300918730784	p.Thr366Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.438	-3.498	2.06	2.443	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T366E	366	T	E	missense	wt-like	1.15452516745349	0.102194154344189	4	0.0510970771720947	1.05437673648092	1.25467359842606	NA	1.18026274206295	1.22525259901955	1.20879484608751	NA	NA	NA	1.00379048264397	0.83906045385541	NA	0.852304784206619	0.894979933699831	0.825816123504201	NA	NA	NA	0.798321362365152	p.Thr366Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.438	-3.414	1.976	2.574	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T366F	366	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.438	-3.89	2.452	2.876	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T366G	366	T	G	missense	wt-like	0.954587503143391	0.18177921158987	7	0.0687060839125981	0.819926053155912	1.08924895313087	0.922462172303581	0.969842767362703	1.04491002535697	NA	1.13591228895887	0.570907530841416	1.0041691594831	1.03390857769709	0.804435413953602	0.745998556292586	0.75530471714518	0.806530474383231	NA	0.804435413953602	0.572726468659948	0.828426146909046	0.813448117085083	p.Thr366Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.438	-3.28	1.842	3.342	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T366H	366	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.438	-4.621	3.183	0.963	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T366I	366	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.438	-3.247	1.809	13.363	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
T366K	366	T	K	missense	possibly_low	0.580247214684084	0.483374832822205	8	0.170898811071747	0.245291699982745	0.915202729385424	0.961611506645077	0.865812667682162	0.991458757984837	0.793856588175538	-0.26781236468887	0.540303461681475	-0.0640865315738386	0.820833631566294	0.67513797519709	0.764624890301253	0.707348591973149	0.780315168685651	0.643844310991342	0.280091156252643	0.557642558768647	0.253070689790577	0.706431639402838	p.Thr366Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.438	-3.397	1.959	2.703	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T366L	366	T	L	missense	wt-like	1.13671409754958	0.214135834368093	5	0.0957644564131383	0.949019211980772	1.32440898311839	1.31289252900313	1.15515103968126	1.19130806109778	1.25501343675582	NA	NA	NA	0.769205421209903	0.846085357674185	0.931756152260204	0.840728712027536	0.878331751493285	0.846085357674185	NA	NA	NA	0.680501471066729	p.Thr366Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.438	-2.885	1.447	10.58	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
T366M	366	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.438	-2.71	1.272	6.873	6.873	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
T366N	366	T	N	missense	possibly_wt-like	0.737898730030418	0.0877420305265674	3	0.0506578849437581	0.638611100007679	0.837186360053158	NA	0.807304198417832	0.767116451399605	0.639275540273818	NA	NA	NA	NA	0.670285932015058	NA	0.680377172314027	0.670285932015058	0.576052554192718	NA	NA	NA	NA	p.Thr366Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.438	-3.501	2.063	2.742	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T366P	366	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.438	-3.672	2.234	1.452	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T366Q	366	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.438	-3.8	2.362	1.65	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T366R	366	T	R	missense	wt-like	1.00721771190338	0.0697989617013337	7	0.0263815277760358	0.955510867605209	1.05892455620156	0.977449406473193	0.976770124748032	0.961728836402277	1.14792149584037	1.03742867619653	NA	1.01005631806928	0.939169125593981	0.767648059186135	0.772160191147521	0.758498112315447	0.765734055440464	0.799120021934914	0.767648059186135	NA	0.831596931626447	0.765865411348311	p.Thr366Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.438	-3.718	2.28	1.975	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T366S	366	T	S	missense	wt-like	1.00134460920165	0.264438636827773	8	0.0934931766543225	0.818101350158932	1.18458786824436	1.28239451833334	1.22113788949287	0.993515597157672	1.19316728908008	0.763045540488841	0.581557174432388	0.773524276331412	1.20241458829657	0.800143292407946	0.917245914911588	0.871147539261107	0.781323950522594	0.818962634293298	0.665155578738175	0.577975387143996	0.704202336740077	0.898079933495701	p.Thr366Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.438	-2.256	0.818	10.969	10.969	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.46	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T366T	366	T	T	synonymous	wt-like	1.07670829905956	0.117061618439823	2	0.0827750642154714	0.914472154379241	1.23894444373987	NA	NA	NA	NA	1.15948336327503	NA	0.993933234844084	NA	0.818076623688354	NA	NA	NA	NA	0.81324010184834	NA	0.822913145528368	NA	p.Thr366=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T366V	366	T	V	missense	wt-like	0.970719071805725	0.204166135885872	4	0.102083067942936	0.770639935206215	1.17079820840524	NA	NA	NA	NA	1.10865403163925	0.969794696114207	0.682397293285749	1.1220302661837	0.781790241268778	NA	NA	NA	NA	0.794253423729707	0.769327058807848	0.65512194575785	0.857707063904015	p.Thr366Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.438	-2.234	0.796	21.912	21.912	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	low	0.805	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T366W	366	T	W	missense	wt-like	1.08654760957044	0.207381477522175	8	0.0733204245242078	0.942842218171808	1.23025300096908	1.28404440194506	1.17110110205439	1.21256133806934	1.30223386900322	0.864569957628103	0.936848305733709	1.17150953407151	0.749512368058212	0.857437686680878	0.918030890792896	0.848081422349035	0.888755473516672	0.866793951012721	0.703078788966816	0.753088682755765	0.918554567025792	0.670610673385571	p.Thr366Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.438	-5.071	3.633	0.397	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T366X	366	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr366Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T366Y	366	T	Y	missense	wt-like	0.985328548715039	0.165817576855808	7	0.0626731530519724	0.862491425935607	1.10816567149447	NA	1.07118857723958	1.0381923097912	1.12853022587135	1.06969830183649	0.638379650572719	0.918120018525337	1.03319075716859	0.790615950604046	NA	0.802023429893137	0.803235754242732	0.790615950604046	0.779701985045815	0.605981633810805	0.782080648125488	0.813087593119397	p.Thr366Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.438	-4.032	2.594	1.729	NA	42.43	0.003566442	0	0.10193486	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	low	0.805	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P367A	367	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.408	-2.146	0.738	22.857	22.857	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
P367C	367	P	C	missense	wt-like	1.06178325685935	0.314458673287222	5	0.140630193916925	0.786153141643292	1.33741337207541	0.562490918454424	1.0634918628713	1.23279615731723	1.40349457346841	NA	NA	NA	1.04664277218538	0.819843841523849	0.574732686246715	0.798475374101669	0.898679690441698	0.911201989019592	NA	NA	NA	0.819843841523849	p.Pro367Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.408	-4.812	3.404	1.691	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P367D	367	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.408	-3.451	2.043	3.032	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P367E	367	P	E	missense	wt-like	1.23694747671438	0.0357719569862759	4	0.0178859784931379	1.20189160303957	1.27200335038919	1.26084363552323	NA	NA	NA	1.27262260874138	1.21766868436953	1.19665497822339	NA	0.899244944543017	0.906992510909842	NA	NA	NA	0.855501889818466	0.891497378176192	0.932097737107234	NA	p.Pro367Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.408	-3.422	2.014	3.277	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P367F	367	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.408	-4.261	2.853	1.859	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P367G	367	P	G	missense	wt-like	0.939889308670315	0.0958274858934245	4	0.0479137429467123	0.845980098130249	1.03379851921038	0.799317518981096	0.999311624145542	1.00242609193076	NA	NA	NA	NA	0.958501999623861	0.772232336969793	0.687409221818644	0.768889364174206	0.785694124624676	NA	NA	NA	NA	0.775575309765379	p.Pro367Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.408	-2.135	0.727	25.43	25.43	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P367H	367	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.408	-4.629	3.221	1.189	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P367I	367	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.408	-3.817	2.409	4.311	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P367K	367	P	K	missense	possibly_wt-like	0.87309617908802	0.341501417136073	3	0.197165935112151	0.486658047290044	1.259534310886	NA	1.21920423360489	0.863688504843803	0.536395798815363	NA	NA	NA	NA	0.717649933419492	NA	0.870256156439328	0.717649933419492	0.53093448501718	NA	NA	NA	NA	p.Pro367Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.408	-3.439	2.031	3.753	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P367L	367	P	L	missense	possibly_wt-like	0.813818432197346	0.371051318881073	8	0.131186451874509	0.55669771126371	1.07093915313098	0.0675862054317357	0.827481601036207	0.914537463040094	0.515364933633908	0.918027272628412	1.24397604533954	0.882931624555496	1.14064231191337	0.732818024228239	0.339268644717578	0.68967861534431	0.742588930174021	0.521711366678945	0.723047118282458	0.90446355794385	0.763128411626986	0.867054927707896	p.Pro367Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.408	-3.389	1.981	5.316	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P367M	367	P	M	missense	wt-like	1.26013247011232	0.151193846961279	3	0.0872918082429095	1.08904366981084	1.4312212704138	NA	1.10005538129508	1.27982970540523	1.40051232363665	NA	NA	NA	NA	0.909894118759613	NA	0.815330540747138	0.921747409913797	0.909894118759613	NA	NA	NA	NA	p.Pro367Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.408	-4.605	3.197	1.615	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P367N	367	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.408	-3.676	2.268	3.576	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P367P	367	P	P	synonymous	possibly_wt-like	0.710433947238111	0.391929946354375	7	0.148135595630366	0.420093514974205	1.00077437950202	NA	1.07196214081262	1.10263859867751	1.0363308385525	0.199689487878523	0.477894912488093	0.259931331396614	0.824590320860917	0.708318429301686	NA	0.802380029681574	0.834843595315359	0.750181767197065	0.45472078266924	0.526883089249736	0.427584569964211	0.708318429301686	p.Pro367=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P367Q	367	P	Q	missense	wt-like	0.954040362391529	0.0898815670902892	2	0.0635558655932171	0.829473154822555	1.0786075699605	NA	NA	NA	NA	1.01759622798475	NA	NA	0.890484496798312	0.750826770348151	NA	NA	NA	NA	0.760239889564708	NA	NA	0.741413651131594	p.Pro367Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.408	-3.882	2.474	2.207	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P367R	367	P	R	missense	wt-like	0.865044371632	0.211095869601607	8	0.0746336604378836	0.718765085139357	1.01132365812464	1.15442460264037	0.799154491467342	0.86928467280244	1.08525653409847	0.797186984665417	1.00616406046332	0.691014655295528	0.517868971623115	0.699151643701083	0.856360833904435	0.676620294565825	0.720394587774444	0.77163820638335	0.677908699627721	0.787252525247586	0.659763200000443	0.554268227617126	p.Pro367Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.408	-3.802	2.394	2.847	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P367S	367	P	S	missense	possibly_wt-like	0.844786324267701	0.269317749605603	6	0.109948510868062	0.629291202812489	1.06028144572291	1.312861890902	NA	0.933779558679107	0.60078104283487	0.570274807260018	0.827439133829461	NA	0.823581512100753	0.703487823476247	0.931741575371101	NA	0.752026263360656	0.559170733012895	0.593148417819064	0.69916388989045	NA	0.707811757062044	p.Pro367Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.408	-3.129	1.721	7.517	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P367T	367	P	T	missense	wt-like	1.08612956637856	0.154492113832783	5	0.0690909737035479	0.950713746262806	1.22154538649432	NA	1.20959635240679	1.10362892845917	0.835093979560579	1.21480011771321	NA	1.06752845375307	NA	0.8353293049953	NA	0.865827084903406	0.8353293049953	0.66192903253859	0.833903002132197	NA	0.862551044180905	NA	p.Pro367Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.408	-2.316	0.908	20.015	20.015	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
P367V	367	P	V	missense	wt-like	1.0729722332188	0.306215872770467	8	0.108263660071477	0.860779358644215	1.28516510779338	0.651510590452594	0.943694616901078	1.04292010829443	1.15578908988126	1.65945922740996	0.775583006965299	1.18244292028063	1.17237830556512	0.804062441043598	0.617086155900026	0.743250859844211	0.805554514660063	0.802570367427132	1	0.673605421150783	0.924443216599924	0.882994268855362	p.Pro367Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.408	-3.335	1.927	5.822	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P367W	367	P	W	missense	wt-like	1.00130337938233	0.170024240775558	4	0.0850121203877789	0.834682685172903	1.16792407359176	NA	NA	1.16757503086511	NA	1.11291557430259	0.799070591254215	0.925652321107417	NA	0.790991383823958	NA	NA	0.866691828377006	NA	0.795845271118485	0.685181810000476	0.786137496529432	NA	p.Pro367Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.408	-5.291	3.883	0.457	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P367X	367	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P367Y	367	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro367Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.408	-4.257	2.849	1.506	NA	12.16	0.003267796	0	0.093399046	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D368A	368	D	A	missense	wt-like	1.04405435553305	0.155486191299937	5	0.0695355386618391	0.907767204110249	1.18034150695584	NA	1.06842301170916	0.862509353204931	NA	1.28547992009127	NA	1.02758257114917	0.976276921510699	0.800748550726862	NA	0.800748550726862	0.717071615594741	NA	0.860304581969145	NA	0.84103645573736	0.78450272974576	p.Asp368Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.4	-2.956	1.556	8.621	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D368C	368	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.4	-4.865	3.465	1.438	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D368E	368	D	E	missense	wt-like	0.991835008125155	0.0636268414058661	5	0.028454788515423	0.936064647447223	1.04760536880309	NA	0.942626037773868	NA	NA	0.922177228418975	0.982792662120047	1.03765618493828	1.07392292737461	0.775733401277461	NA	0.742758262850283	NA	NA	0.724597283753186	0.775733401277461	0.846462037566682	0.833545246461361	p.Asp368Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.4	-2.984	1.584	4.073	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 17, 2015)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D368F	368	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.4	-4.161	2.761	1.646	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D368G	368	D	G	missense	wt-like	0.989320088057932	0.174104218524256	8	0.0615551367758429	0.868674236913843	1.10996593920202	1.15046583748631	1.04440204255677	1.04787531970114	1.16790177994195	0.63220650111243	1.01450943549079	0.850097215344529	1.00710257282955	0.795675292955823	0.854477346400449	0.789675288209927	0.807984810295873	0.807882406321405	0.616282248201554	0.791365732686295	0.745444015766572	0.79998485322535	p.Asp368Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.4	-2.096	0.696	21.634	21.634	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
D368H	368	D	H	missense	possibly_wt-like	0.739986538118539	0.178519360225166	4	0.0892596801125829	0.565040779826311	0.914932296410768	NA	0.496941284745381	0.737311159440855	0.806544018604431	NA	NA	NA	0.91914968968349	0.652538128171583	NA	0.537305092381987	0.655667853183282	0.649408403159884	NA	NA	NA	0.755810688560719	p.Asp368His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.4	-4.472	3.072	1.524	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D368I	368	D	I	missense	possibly_wt-like	0.776131965563533	0.637089338189702	3	0.367823700901665	0.055210759136037	1.49705317199103	NA	1.25189216683113	NA	NA	NA	0.0523280046364231	NA	1.02417572522305	0.808559810841263	NA	0.885324743533123	NA	NA	NA	0.317132782608916	NA	0.808559810841263	p.Asp368Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.4	-3.863	2.463	2.642	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D368K	368	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.4	-3.397	1.997	4.277	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D368L	368	D	L	missense	possibly_wt-like	0.824771859815713	0.296205467668728	2	0.20944889481309	0.414259569380339	1.23528415025109	1.0342207546288	NA	NA	NA	NA	NA	NA	0.615322965002623	0.701192485989743	0.799170665543962	NA	NA	NA	NA	NA	NA	0.603214306435525	p.Asp368Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.4	-3.533	2.133	3.347	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D368M	368	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.4	-4.708	3.308	1.18	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D368N	368	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.4	-3.24	1.84	4.339	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D368P	368	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.4	-3.637	2.237	2.297	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D368Q	368	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.4	-3.72	2.32	2.61	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D368R	368	D	R	missense	wt-like	1.05236513386479	0.127902358163594	3	0.0738444609157387	0.907632650012163	1.19709761771741	NA	0.917607782474513	1.06740495775252	1.17208266136732	NA	NA	NA	NA	0.809715938314104	NA	0.731225268203484	0.817563169366682	0.809715938314104	NA	NA	NA	NA	p.Asp368Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.4	-3.802	2.402	3.125	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D368S	368	D	S	missense	possibly_low	0.706149611692471	0.423529516585951	4	0.211764758292976	0.291098312243409	1.12120091114153	0.170821285658409	1.15395273515475	NA	NA	0.596293578563511	NA	0.90353084739321	NA	0.688545215037568	0.388385471812015	0.840176313807754	NA	NA	0.602867413129126	NA	0.77422301694601	NA	p.Asp368Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.4	-2.253	0.853	17.354	17.354	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D368T	368	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.4	-2.298	0.898	12.265	12.265	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D368V	368	D	V	missense	wt-like	0.919852004951653	0.23079116652417	8	0.0815969994435971	0.759924824795668	1.07977918510764	0.906740411110507	0.835072218128021	0.906530636743233	0.527136450022293	1.13997305931306	1.25461513657751	1.05133195933455	0.737416168384055	0.738590236991521	0.738518511481804	0.693177762076899	0.738661962501239	0.52687378333341	0.805952265290172	0.909707275461285	0.85382771929914	0.664535380602557	p.Asp368Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.4	-3.521	2.121	3.568	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D368W	368	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.4	-5.291	3.891	0.396	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D368X	368	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D368Y	368	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp368Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.4	-4.257	2.857	1.42	NA	42.43	0.003334082	0	0.095293624	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
V369A	369	V	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.653	-2.147	0.494	24.222	24.222	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
V369C	369	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.653	-4.616	2.963	1.792	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V369D	369	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.653	-2.389	0.736	31.305	31.305	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
V369E	369	V	E	missense	possibly_wt-like	0.742856237415192	0.565801501117367	2	0.400082078245618	-0.0412902268061555	1.52700270163654	NA	0.342774159169574	NA	NA	NA	NA	NA	1.14293831566081	0.667222366592554	NA	0.466236642056272	NA	NA	NA	NA	NA	0.868208091128835	p.Val369Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.653	-3.349	1.696	7.233	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V369F	369	V	F	missense	wt-like	1.09048488909494	0.204493066193544	7	0.0772911139978839	0.938997089334105	1.24197268885577	NA	0.816180877607544	1.05518904111929	1.09449991394549	1.23800041243985	1.4378119871511	1.07980145149957	0.911910539901716	0.811571842974236	NA	0.684469172029888	0.811571842974236	0.775691904861219	0.842569189824543	1	0.869161199678103	0.75217483964874	p.Val369Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.653	-3.886	2.233	3.238	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
V369G	369	V	G	missense	wt-like	1.10023108744797	0.113193912133333	8	0.0400200914292572	1.02179314958862	1.17866902530731	1.0716034515521	1.23418157507883	1.07169019381337	1.18785576218796	1.17084510265025	0.866770451762083	1.13781556305246	1.0610865994867	0.81857450761848	0.816956474951711	0.877160458796758	0.819664873944408	0.816633255988601	0.817484141292551	0.718549222360498	0.900407216854771	0.827098225721089	p.Val369Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.653	-3.243	1.59	6.553	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
V369H	369	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.653	-4.673	3.02	1.404	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V369I	369	V	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.653	-2.309	0.656	19.607	19.607	83.62	0.003077219	0	0.087952053	0	NA	NA	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Jan 12, 2017)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
V369K	369	V	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.653	-3.518	1.865	3.771	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V369L	369	V	L	missense	possibly_low	0.69084694975208	0.393159050265636	8	0.139002715263847	0.418406634081664	0.963287265422496	0.578242152465869	1.01901408644529	0.868999982456658	0.935854916768665	0.00900867120873555	0.380155500680897	0.517139776336286	1.21836051165424	0.644172325188518	0.582226753532422	0.777971867710638	0.720254960693353	0.706117896844613	0.383494284641499	0.478710002434917	0.566115339003763	0.906088742518615	p.Val369Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.653	-2.864	1.211	12.102	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
V369M	369	V	M	missense	possibly_wt-like	0.848089794736155	0.159418926730827	4	0.0797094633654137	0.69186211731293	1.00431747215938	NA	NA	NA	NA	0.882065252317452	0.74987429175318	0.702194124112832	1.05822551076116	0.687699165690049	NA	NA	NA	NA	0.709613943338656	0.660934297528166	0.665784388041442	0.825661249467876	p.Val369Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.653	-4.218	2.565	2.667	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V369N	369	V	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.653	-3.687	2.034	5.474	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V369P	369	V	P	missense	wt-like	1.03286249739511	0.0159247317513475	2	0.0112604858099545	1.01079235075917	1.05493264403104	NA	NA	NA	NA	1.02160201158515	NA	NA	1.04412298320506	0.790157241836623	NA	NA	NA	NA	0.761736201268723	NA	NA	0.818578282404524	p.Val369Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.653	-3.76	2.107	2.43	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V369Q	369	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.653	-3.918	2.265	2.425	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V369R	369	V	R	missense	possibly_low	0.217625651820748	0.497857142406696	3	0.287437955186484	-0.345742388134598	0.780993691776094	0.587794391118336	NA	NA	NA	-0.348369550675429	NA	NA	0.413452115019337	0.501825064273421	0.586771484385809	NA	NA	NA	0.25	NA	NA	0.501825064273421	p.Val369Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.653	-3.926	2.273	2.644	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
V369S	369	V	S	missense	possibly_low	0.397141422694447	0.369806101812238	5	0.165382316429274	0.0729980388132622	0.721284806575632	NA	0.788424109965391	0.601587679293615	0.375777109212614	-0.195591215968501	0.415509430969116	NA	NA	0.496134989157561	NA	0.671673769281014	0.589101938148421	0.460494911145316	0.307068487253908	0.496134989157561	NA	NA	p.Val369Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.653	-2.371	0.718	10.969	10.969	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
V369T	369	V	T	missense	wt-like	1.07361870604968	0.194303363552964	5	0.0868951058322565	0.903307428185662	1.2439299839137	1.23660807655254	1.03895125311047	1.07473582483453	0.769243871700331	NA	NA	NA	1.24855450405054	0.8211586111781	0.895461801030151	0.787162566009563	0.8211586111781	0.63305036624786	NA	NA	NA	0.921253616531692	p.Val369Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.653	-3.182	1.529	4.189	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
V369V	369	V	V	synonymous	wt-like	1.0133489972141	0.201403393740778	6	0.0822225911882927	0.852195679769481	1.17450231465871	1.28236034937036	NA	0.832619015942194	1.01284337113201	1.19121420333288	1.0047608780934	0.75629616541373	NA	0.763221118569578	0.917229658121328	NA	0.702411826084214	0.739881302160769	0.825092770912125	0.786560934978386	0.694923390027869	NA	p.Val369=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V369W	369	V	W	missense	possibly_low	0.648760043583925	0.69218921273187	2	0.489451686186883	-0.310547633514766	1.60806772068262	NA	0.159308357397042	1.13821172977081	NA	NA	NA	NA	NA	0.616976260070347	NA	0.381661995087666	0.852290525053028	NA	NA	NA	NA	NA	p.Val369Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.653	-5.316	3.663	0.454	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
V369X	369	V	X	nonsense	low	0.346763932945848	0.0123855301297103	2	0.00875789234330845	0.329598779372484	0.363929086519211	NA	NA	NA	NA	0.355521825289156	0.338006040602539	NA	NA	0.48543287006169	NA	NA	NA	NA	0.512930055458637	0.457935684664744	NA	NA	p.Val369Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V369Y	369	V	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val369Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.653	-4.025	2.372	1.469	NA	83.62	0.003077219	0	0.087952053	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S370A	370	S	A	missense	possibly_wt-like	0.805402467078341	0.239888669435901	4	0.119944334717951	0.57031589088154	1.04048904327514	NA	0.727682308506913	0.969607802435788	1.02282831085646	NA	NA	NA	0.501491446514204	0.693966516966083	NA	0.643672821066385	0.769598313732252	0.74426021286578	NA	NA	NA	0.54604264745327	p.Ser370Ala	0	0	conflict	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.277	-2.548	1.271	6.189	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
S370C	370	S	C	missense	possibly_wt-like	0.787571564095869	0.226466952231708	5	0.101279099969459	0.589068175769097	0.98607495242264	NA	0.736999577877252	0.564599660933497	0.844493052691165	NA	1.14705246638123	NA	0.644713062596203	0.647967925440577	NA	0.647967925440577	0.570961073466818	0.666051010545921	NA	0.856692572859834	NA	0.61797542584593	p.Ser370Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.277	-4.6	3.323	0.819	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S370D	370	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.277	-3.164	1.887	2.684	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S370E	370	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.277	-3.178	1.901	2.063	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S370F	370	S	F	missense	possibly_wt-like	0.897594114478112	0.279536683079798	6	0.114120372989266	0.673922293516873	1.12126593543935	NA	1.1622689827713	1.00451025589804	0.825949899574858	0.622879708471363	NA	0.547116481306875	1.22283935884623	0.722317595071138	NA	0.844009964000204	0.786716307974341	0.657918882167936	0.612798338339742	NA	0.58226059424148	0.908338234818237	p.Ser370Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.277	-3.988	2.711	1.275	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S370G	370	S	G	missense	wt-like	1.02947609330566	0.06469061288266	8	0.0228715855242213	0.984648609408854	1.07430357720246	0.981547812320827	0.979455419227052	1.04897938336983	1.01067530207064	1.04928091436498	0.937793618638733	1.13222746342762	1.09584883302557	0.7730927174493	0.774110116414582	0.759735987877954	0.808526301040758	0.738930492132462	0.772075318484017	0.75355460167014	0.897397503318029	0.844557489971767	p.Ser370Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.277	-1.816	0.539	40.232	40.232	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
S370H	370	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.277	-4.376	3.099	1.02	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S370I	370	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.277	-3.748	2.471	1.474	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S370K	370	S	K	missense	possibly_wt-like	0.872301001730982	0.204722210057289	3	0.118196423085671	0.640640269381609	1.10396173408036	NA	0.739172482505658	1.10803612561227	NA	NA	NA	NA	0.769694397075014	0.680747058244884	NA	0.648969597905246	0.837490825691035	NA	NA	NA	NA	0.680747058244884	p.Ser370Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.277	-3.195	1.918	2.702	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
S370L	370	S	L	missense	wt-like	1.07215587831771	0.158810735035993	8	0.0561480738345855	0.96210767580063	1.1822040808348	1.09812108837684	1.09949778309168	0.861678169565934	0.838137063586541	1.27886682179312	1.25236874176253	1.0537543720782	1.09482298628684	0.836807602164535	0.82957294388857	0.815073497359506	0.716663959532342	0.663263581728196	0.857834339597016	0.908600088806063	0.855132414797721	0.844042260440499	p.Ser370Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.277	-3.321	2.044	2.22	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S370M	370	S	M	missense	wt-like	0.827261681055007	0.148682856982821	8	0.0525673282093713	0.724231611001143	0.930291751108871	0.793477872428066	0.798933838239114	0.740892609825591	0.856121701269829	1.05299001243421	0.871979978370566	0.95207681083732	0.55162062503536	0.680574716125691	0.684630855110273	0.676518577141108	0.657424384343206	0.671150772302244	0.77346080691923	0.721116855753561	0.800369552108399	0.571219929962803	p.Ser370Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.277	-4.443	3.166	0.78	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S370N	370	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.277	-3.144	1.867	3.043	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S370P	370	S	P	missense	possibly_wt-like	0.753954349405598	0.361243738465677	6	0.147477138669387	0.46490446907058	1.04300422974062	NA	1.0387343720964	0.678912173636765	0.848452743097234	0.100903874195572	0.741929644414114	NA	1.1147932889935	0.662403068349697	NA	0.787062587512091	0.627025926797812	0.667787538876204	0.41782061913395	0.65701859782319	NA	0.854072306171934	p.Ser370Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.277	-3.575	2.298	1.452	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S370Q	370	S	Q	missense	wt-like	1.05428518431396	0.11180972818634	8	0.0395307085015929	0.976806419367491	1.13176394926044	1.0159082914212	1.01613368275047	1.09971687902226	1.23318369539461	1.19315638212318	0.930254888856447	1.00914267598559	0.936784978957945	0.808138136852806	0.790458025547307	0.776644050083251	0.833410630716191	0.836511890956088	0.825818248158305	0.749838967643286	0.831104850036707	0.764667978332841	p.Ser370Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.277	-3.637	2.36	1.456	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S370R	370	S	R	missense	wt-like	0.833561931826351	0.108855693202839	8	0.038486299417245	0.758130171070326	0.908993692582377	0.928416880256651	0.949942291827627	0.868991997443155	0.94795774280794	0.643925361344788	0.79038054266178	0.766835575328243	0.772045062940628	0.706012728214929	0.748831666513323	0.746130932839737	0.720251044423818	0.711425609857092	0.620659685794937	0.680898722374635	0.700599846572766	0.681927675608463	p.Ser370Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.277	-3.629	2.352	1.833	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000335015075678406	0.000325978971769186	0.000325978971769186	0.000258165067875899	0.000353335018337314	0.000234616783799316	0.000177090318965793	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S370S	370	S	S	synonymous	wt-like	1.03365356998029	0.275948182704062	4	0.137974091352031	0.763229320130668	1.30407781982991	1.28913033788621	NA	NA	NA	1.19690094378723	0.667991849105191	NA	0.980591149142519	0.806943262889417	0.920450659690121	NA	NA	NA	0.827216983587685	0.620576677757831	NA	0.786669542191149	p.Ser370=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S370T	370	S	T	missense	possibly_wt-like	0.836881898363596	0.233484259682559	8	0.0825491516609292	0.67508853415384	0.998675262573352	0.575297912866459	1.24050644286179	0.90715111038695	0.823890219913259	0.713154617806471	0.810918863521482	0.559140333242574	1.06499568630979	0.674018553151225	0.580825953465127	0.880076116399968	0.738966275327614	0.65701560647795	0.646519431861419	0.691021499824501	0.588736561451113	0.829061556982492	p.Ser370Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.277	-2.969	1.692	2.326	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
S370V	370	S	V	missense	wt-like	0.853525171266672	0.0875963070100032	7	0.0331082920165903	0.78863411132452	0.918416231208824	0.772674730341946	0.954674042859386	0.881018675264884	0.813487590472224	0.736244173887996	0.968117475066829	0.848459510973438	NA	0.726149558175192	0.674733208587198	0.748312190432095	0.726149558175192	0.652453517303983	0.655144254480834	0.76850040235853	0.744561959012798	NA	p.Ser370Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.277	-3.449	2.172	1.939	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S370W	370	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.277	-5.133	3.856	0.434	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S370X	370	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S370Y	370	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser370Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.277	-4.083	2.806	0.888	NA	78.91	0.00302388	0	0.086427526	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D371A	371	D	A	missense	possibly_wt-like	0.782144118051231	0.450351607514591	7	0.170216908003111	0.448525108805366	1.1157631272971	1.187038751581	0.923151049338525	0.880531542587473	1.16511312322516	-0.146524779620675	0.664126819859453	NA	0.801572319387686	0.725910642754072	0.871877880152974	0.733780620937056	0.725910642754072	0.806659436620359	0.325396657296356	0.618671710396619	NA	0.696757682786524	p.Asp371Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.154	-3.043	1.889	6.189	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D371C	371	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.154	-4.958	3.804	0.819	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D371D	371	D	D	synonymous	wt-like	1.04512213885286	0.271442596398265	7	0.102595657899927	0.844038344398814	1.24620593330691	1.21950567066865	1.21047993466256	1.24542606699073	1.12750762547811	0.56026622185665	1.19182947488846	NA	0.760839977424886	0.866234401453014	0.887324877894591	0.866234401453014	0.904874060740129	0.790167487625552	0.589409832569935	0.878761937492208	NA	0.676299943180048	p.Asp371=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	187	187	0	13	13	0	133	133	0	5.05	5.05	0	NA	NA	NA	NA	NA	NA	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
D371E	371	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.154	-2.791	1.637	2.063	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D371F	371	D	F	missense	possibly_wt-like	0.966420873264636	0.393731985232975	3	0.227321267662824	0.520879375725512	1.41196237080376	NA	0.942829708433775	0.58501489298996	1.37141801837017	NA	NA	NA	NA	0.742852151596813	NA	0.742852151596813	0.580973774298046	0.897134766344664	NA	NA	NA	NA	p.Asp371Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.154	-4.162	3.008	1.275	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D371G	371	D	G	missense	wt-like	0.808168216484714	0.133215959808929	8	0.0470989542715843	0.71585596240291	0.900480470566518	1.0524638589772	0.636002495062661	0.691778607625755	0.814978186003808	0.874908397075874	0.835550538652343	0.864982234698216	0.694681413781853	0.678134500038362	0.807850306224035	0.601409969999413	0.63333630102918	0.653107220271675	0.706940587179123	0.703161779805048	0.753460988843481	0.643071933138699	p.Asp371Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.154	-1.876	0.722	40.232	40.232	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D371H	371	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.154	-4.376	3.222	1.02	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D371I	371	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.154	-3.931	2.777	1.474	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D371K	371	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.154	-3.378	2.224	2.702	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D371L	371	D	L	missense	possibly_low	0.600996237741602	0.332049236198613	6	0.135558533027915	0.335306395209804	0.866686080273399	0.634880926287607	0.245550510331244	0.791801557382596	0.779151320785205	0.15627138699628	NA	NA	0.998321724666678	0.623284722743631	0.609174152173804	0.421418176172934	0.682392803027411	0.637395293313457	0.438502479586278	NA	NA	0.79557468929704	p.Asp371Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.154	-3.679	2.525	2.22	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D371M	371	D	M	missense	possibly_wt-like	0.859349054491756	0.300192621687428	8	0.106134119228674	0.651330003272675	1.06736810571084	1.15045881623495	1.07264145565666	0.799760351854494	1.05987352568941	0.840451059717882	0.185371937347185	0.906330481655493	0.859904807777966	0.743280755331806	0.854474005853922	0.802693182392109	0.68629621337337	0.760506448925101	0.69406946823683	0.382706503610056	0.775730881462179	0.726055061738512	p.Asp371Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.154	-4.8	3.646	0.78	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D371N	371	D	N	missense	possibly_wt-like	0.752910765501065	0.0650394201533401	2	0.0459898150348678	0.662772384377066	0.843049146625065	NA	0.706920950466197	0.798900580535933	NA	NA	NA	NA	NA	0.659988360413626	NA	0.634102184414115	0.685874536413137	NA	NA	NA	NA	NA	p.Asp371Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.154	-3.144	1.99	3.043	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	1	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D371P	371	D	P	missense	possibly_wt-like	0.845864108955013	0.357592964694107	2	0.252856410239804	0.350274651624911	1.34145356628511	1.09872051919482	NA	NA	NA	0.593007698715208	NA	NA	NA	0.715749075852606	0.829858138996444	NA	NA	NA	0.601640012708769	NA	NA	NA	p.Asp371Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.154	-3.575	2.421	1.452	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D371Q	371	D	Q	missense	wt-like	1.14147010060873	0.251494515932122	2	0.177833477646832	0.792922889175429	1.49001731204203	NA	NA	NA	NA	NA	1.31930357825556	NA	0.963636622961896	0.859872303041073	NA	NA	NA	NA	NA	0.941590441721988	NA	0.778154164360158	p.Asp371Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.154	-3.637	2.483	1.456	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D371R	371	D	R	missense	low	0.468894693933304	0.234791890150794	6	0.0958533877688406	0.281025506110224	0.656763881756384	NA	0.691017140762541	0.570339481896128	0.749218169369795	0.169749906841683	0.343933761234554	NA	0.289109703495124	0.517316739534708	NA	0.626770795794833	0.573776182791301	0.624268063627059	0.44353721660887	0.460857296278115	NA	0.439374329686964	p.Asp371Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.154	-3.803	2.649	1.833	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D371S	371	D	S	missense	wt-like	0.897198987472966	0.229100588099576	8	0.0809992897095181	0.738443296868984	1.05595467807695	0.870438049140841	0.799932079882496	1.04262880661234	1.11364431894363	1.12395631402315	0.428176539644657	0.993809810651574	0.80500598088504	0.752667206628066	0.721246700077495	0.676978749738741	0.805411645032799	0.784087713178636	0.799969405049027	0.502378261084788	0.82284667007376	0.698482232601848	p.Asp371Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.154	-3.031	1.877	4.08	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D371T	371	D	T	missense	wt-like	0.952693035800862	0.182291268598889	3	0.105245912996487	0.746414836807711	1.15897123479401	1.06172719458694	NA	NA	NA	0.742247220214805	NA	NA	1.05410469260084	0.812257583793465	0.812257583793465	NA	NA	NA	0.657386619364856	NA	NA	0.823591576553749	p.Asp371Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.154	-3.342	2.188	2.326	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D371V	371	D	V	missense	wt-like	0.963020875161858	0.0491482333639397	3	0.0283757457628652	0.907405435432177	1.01863631489154	NA	NA	NA	NA	0.986343701732146	NA	0.996165523557869	0.906553400195559	0.749484226640429	NA	NA	NA	NA	0.748565888800658	NA	0.824115441480632	0.749484226640429	p.Asp371Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.154	-3.624	2.47	1.939	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D371W	371	D	W	missense	wt-like	0.98671822877732	0.0105689380762554	2	0.00747336778366087	0.972070697078123	1.00136576047652	NA	NA	NA	NA	0.979244860993659	NA	0.994191596560981	NA	0.784483250347322	NA	NA	NA	NA	0.74591420325258	NA	0.823052297442064	NA	p.Asp371Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.154	-5.288	4.134	0.434	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D371X	371	D	X	nonsense	low	0.358778184918118	0.264460463847805	6	0.107965532261147	0.147169630114573	0.570386739721662	0.0545607373017663	0.0706252484887593	0.378437498532437	0.370557580493331	0.72943520757384	NA	NA	0.549052837118573	0.468931630652376	0.333071432834185	0.340780574378559	0.479657382523649	0.458205878781103	0.652600847995503	NA	NA	0.569930263470897	p.Asp371Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D371Y	371	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp371Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.154	-4.258	3.104	0.888	NA	78.91	0.002862307	0	0.081809512	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
N372A	372	N	A	missense	wt-like	0.947073932168236	0.213437047910041	6	0.0871353099309279	0.776291862921882	1.11785600141459	1.08513353807329	1.01064949038472	0.930438029210486	1.12752212774395	0.535155598337172	NA	NA	0.993544809259799	0.782144888657882	0.823393772416632	0.774115929699176	0.750387402004807	0.790173847616588	0.580030064810273	NA	NA	0.793175492815646	p.Asn372Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.346	-3.216	1.87	3.189	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N372C	372	N	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.346	-5	3.654	0.587	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N372D	372	N	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.346	-2.092	0.746	31.305	31.305	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
N372E	372	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.346	-3.022	1.676	7.233	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N372F	372	N	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.346	-4.099	2.753	1.542	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N372G	372	N	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.346	-2.938	1.592	3.711	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N372H	372	N	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.346	-2.458	1.112	17.658	17.658	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
N372I	372	N	I	missense	possibly_wt-like	0.767391021292751	0.274829737306317	5	0.122907594971067	0.526496561723023	1.00828548086248	0.715322334807756	NA	NA	NA	0.421116676357539	0.950106107261662	0.627338134708352	1.12307185332845	0.647446285491682	0.647446285491682	NA	NA	NA	0.537432213629813	0.759623091058115	0.625467446730081	0.858230199023625	p.Asn372Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.346	-3.923	2.577	1.817	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
N372K	372	N	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.346	-3.227	1.881	3.598	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
N372L	372	N	L	missense	wt-like	1.048017965168	0.230506258124879	8	0.0814962691130194	0.888288212832096	1.2077477175039	0.970403937800336	1.14657917403892	1.01718115670377	1.24008085866677	1.36181788636075	0.579823129489501	1.04621223176966	1.02204534651428	0.822133529250661	0.768808122588615	0.836777226227137	0.792930782474508	0.839536652539044	0.888819700054417	0.577120723748443	0.851070267859304	0.807489832274184	p.Asn372Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.346	-3.536	2.19	2.237	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N372M	372	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.346	-4.658	3.312	0.728	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N372P	372	N	P	missense	wt-like	1.07023192158788	0.0580831312400089	3	0.0335343114567955	1.00450587888621	1.13595796428955	NA	NA	NA	NA	1.09765054080907	NA	1.10953029655836	1.00351492739621	0.798182965277376	NA	NA	NA	NA	0.790143203668761	NA	0.885172959204964	0.798182965277376	p.Asn372Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.346	-3.744	2.398	1.821	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N372Q	372	N	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn372Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.346	-3.587	2.241	2.425	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N372R	372	N	R	missense	possibly_low	0.612157655766354	0.263553246396142	6	0.107595162287426	0.401275012772257	0.823040298760452	NA	0.764443364652772	0.638511403392925	0.804029872172531	0.423855990480888	0.863502212663115	NA	0.178603091235895	0.627758544959427	NA	0.660619049277264	0.607211269551499	0.648305820367355	0.538455451076619	0.71693839656428	NA	0.383872598397913	p.Asn372Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.346	-3.47	2.124	2.361	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N372S	372	N	S	missense	wt-like	1.18007098140506	0.12653126877095	8	0.0447355590900383	1.09239089676032	1.2677510660498	1.03807445673586	1.17556528879333	1.23860848385951	1.24146626181507	1.30004002773542	1.32204681897657	1.16831079855174	0.956455714772967	0.85794133512693	0.801004166517181	0.850139337305394	0.901530360306253	0.840144223224926	0.865743332948465	0.942942510155424	0.916831749209248	0.77454756717502	p.Asn372Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.346	-2.966	1.62	4.125	NA	78.91	0.002669038	0	0.076285558	8.413e-06	2	237716	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.5
N372T	372	N	T	missense	possibly_wt-like	0.822819659632919	0.745493345319986	3	0.430410783599568	-0.0207699747798979	1.66640929404574	1.43458489852211	NA	NA	NA	NA	-0.00753202208467958	NA	1.04140610246133	0.817213734329977	0.989654524201716	NA	NA	NA	NA	0.287629410216401	NA	0.817213734329977	p.Asn372Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.346	-3.227	1.881	2.79	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
N372V	372	N	V	missense	possibly_low	0.651654637052199	0.205233774349695	4	0.102616887174848	0.450529233983888	0.852780040120511	NA	0.568030806519571	0.613660438077955	0.477377784873727	NA	NA	NA	0.947549518737544	0.582549608967982	NA	0.570076165514589	0.595023052421375	0.505052044044125	NA	NA	NA	0.770074447521274	p.Asn372Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.346	-3.667	2.321	1.936	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.205	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
N372W	372	N	W	missense	possibly_wt-like	0.729668982309707	0.434107480600403	8	0.153480171648176	0.428853373538256	1.03048459108116	0.90601823731025	0.41578315767625	0.206961202373219	0.052180725987901	1.08963888383531	1.13226124592149	1.0063312222198	1.02817718315344	0.762662732436123	0.738174918145106	0.499892561658604	0.395556410840312	0.31858121855325	0.787150546727141	0.849402384243703	0.829590619614042	0.810569535311833	p.Asn372Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.346	-5.355	4.009	0.289	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N372X	372	N	X	nonsense	low	0.4654613808146	0.0918028020587768	2	0.0649143838676874	0.338231526355325	0.592691235273875	NA	NA	NA	NA	NA	NA	0.400546996946913	0.530375764682287	0.531934489248071	NA	NA	NA	NA	NA	NA	0.503319238366176	0.560549740129966	p.Asn372Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N372Y	372	N	Y	missense	wt-like	0.973983414369028	0.289352184013113	6	0.118127534465339	0.74245770123445	1.20550912750361	0.429149442462395	1.09850178793318	1.15757768397361	1.22051459901792	0.892456191372699	NA	1.04570078145436	NA	0.822785099783995	0.511291942979628	0.814614360353594	0.861788604977255	0.830955839214395	0.71349535214029	NA	0.850794804098696	NA	p.Asn372Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.346	-3.855	2.509	2.895	NA	78.91	0.002669038	0	0.076285558	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E373A	373	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.005	-2.933	1.928	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373C	373	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.005	-5.168	4.163	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E373D	373	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.005	-2.649	1.644	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373F	373	E	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.005	-4.148	3.143	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E373G	373	E	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.005	-3.214	2.209	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373H	373	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.005	-4.086	3.081	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E373I	373	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.005	-3.866	2.861	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E373K	373	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.005	-2.863	1.858	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373L	373	E	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.005	-3.439	2.434	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E373M	373	E	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.005	-4.561	3.556	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E373N	373	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.005	-3.304	2.299	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E373P	373	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.005	-3.51	2.505	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E373Q	373	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.005	-3.08	2.075	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373R	373	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.005	-3.339	2.334	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E373S	373	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.005	-3.016	2.011	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E373T	373	E	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.005	-3.277	2.272	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E373V	373	E	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.005	-3.384	2.379	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E373W	373	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.005	-5.178	4.173	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E373X	373	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E373Y	373	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu373Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.005	-4.018	3.013	NA	NA	NA	0.0025473	0	0.07280609	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
P374A	374	P	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.292	-2.096	0.804	21.707	21.707	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P374C	374	P	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.292	-4.737	3.445	1.606	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P374D	374	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.292	-3.528	2.236	2.189	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P374E	374	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.292	-3.426	2.134	3.017	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P374F	374	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.292	-4.095	2.803	3.953	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P374G	374	P	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.292	-3.232	1.94	5.872	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P374H	374	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.292	-4.633	3.341	1.118	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P374I	374	P	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.292	-3.505	2.213	8.31	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P374K	374	P	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.292	-3.41	2.118	3.379	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P374L	374	P	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.292	-2.219	0.927	27.115	27.115	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
P374M	374	P	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.292	-4.328	3.036	3.599	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P374N	374	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.292	-3.851	2.559	1.968	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P374Q	374	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.292	-3.853	2.561	1.943	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P374R	374	P	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.292	-3.798	2.506	2.37	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P374S	374	P	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.292	-3.229	1.937	6.313	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
P374T	374	P	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.292	-3.286	1.994	3.754	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
P374V	374	P	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.292	-3.179	1.887	6.92	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P374W	374	P	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.292	-5.311	4.019	0.534	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P374X	374	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P374Y	374	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro374Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.292	-4.151	2.859	1.613	NA	74.94	0.002183462	0	0.062406982	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D375A	375	D	A	missense	possibly_low	0.624890669091212	0.485780030144753	4	0.242890015072376	0.148834987344963	1.10094635083746	0.803573288291644	0.79033713519644	NA	0.99570469842047	-0.0900524455437055	NA	NA	NA	0.680994829321721	0.689434016926286	0.672555641717156	NA	0.732365110828888	0.346491210288128	NA	NA	NA	p.Asp375Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.254	-3.167	1.913	4.71	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D375C	375	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.254	-5.04	3.786	0.709	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D375E	375	D	E	missense	wt-like	1.02389082964816	0.0723207935307829	7	0.0273346906144715	0.970315820515252	1.07746583878107	1.03356988444071	1.02723054822142	1.13680827090863	1.07061332297225	0.948434100578194	0.920857427963945	NA	1.02972225245199	0.781759518310004	0.798860996791644	0.781759518310004	0.851602195198287	0.765216403575733	0.73440521873965	0.745207215814184	NA	0.811345543364905	p.Asp375Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.254	-2.048	0.794	25.431	25.431	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D375F	375	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.254	-4.205	2.951	1.343	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D375G	375	D	G	missense	low	0.58939510334617	0.123366895419031	7	0.0466283036138385	0.498005307602848	0.680784899089492	0.397187537854828	0.492425999501183	0.676126095847288	0.770918254661697	0.544887099637867	0.608414912801648	NA	0.635805823118681	0.591212832900927	0.496085219269318	0.535223621874671	0.625659488085707	0.633784669476137	0.583665148665621	0.591212832900927	NA	0.613501782125417	p.Asp375Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.254	-3.036	1.782	4.624	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D375H	375	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.254	-4.219	2.965	2.313	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D375I	375	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.254	-3.923	2.669	1.922	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D375K	375	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.254	-3.221	1.967	6.513	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D375L	375	D	L	missense	possibly_low	0.550677389005199	0.265845148152268	7	0.100480021323432	0.353740166045456	0.747614611964942	0.511839275626422	0.836324691669148	0.665006547733977	0.463526315139303	0.868482350518594	0.106181824106412	NA	0.403380718242538	0.550633823947488	0.550633823947488	0.693755131300781	0.620205878333483	0.498977460644117	0.704540215707928	0.343675859476976	NA	0.496766724811343	p.Asp375Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.254	-3.627	2.373	3.157	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D375M	375	D	M	missense	possibly_low	0.6137957171882	0.225320502237152	3	0.130088852620561	0.358826251261761	0.868765183114639	NA	NA	NA	NA	0.467750966789506	NA	0.500344161530873	0.873292023244221	0.557069331840072	NA	NA	NA	NA	0.554851885170395	NA	0.557069331840072	0.732778764694619	p.Asp375Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.254	-4.748	3.494	1.07	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D375N	375	D	N	missense	possibly_low	0.416215591069451	0.38351840043473	3	0.221424451730166	-0.0177683596182021	0.850199541757103	NA	NA	NA	-0.00917553654963731	0.735532704667179	NA	0.52228960509081	NA	0.568889002745454	NA	NA	NA	0.291673335054738	0.654878493813671	NA	0.568889002745454	NA	p.Asp375Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.254	-2.192	0.938	22.87	22.87	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D375P	375	D	P	missense	wt-like	1.16782237978447	0.189947527294252	3	0.10966625601524	0.952880467675251	1.38276429189369	1.22484312265176	NA	NA	NA	0.955895707855622	NA	1.32272830884603	NA	0.889864312218694	0.889864312218694	NA	NA	NA	0.737192411312619	NA	1	NA	p.Asp375Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.254	-3.608	2.354	2.241	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D375Q	375	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.254	-3.482	2.228	5.578	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D375R	375	D	R	missense	low	0.506526816996756	0.153290437967341	8	0.0541963540888811	0.400303914889169	0.612749719104343	0.501502463274628	0.692339365532853	0.691495199637715	0.385744646202829	0.27089291831833	0.631385205069755	0.461954050852615	0.416900687085325	0.541054241613582	0.545715811350647	0.627380319161487	0.633197302883601	0.464866189854408	0.481317957394855	0.602534262640816	0.536392671876516	0.503557102892869	p.Asp375Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.254	-3.645	2.391	4.245	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D375S	375	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.254	-3.025	1.771	5.089	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D375T	375	D	T	missense	low	0.339157504770684	0.221345997771277	3	0.127794171397293	0.0886855313978508	0.589629478143516	NA	0.202405658324864	NA	NA	0.22053543308561	NA	NA	0.594531422901577	0.462507531756592	NA	0.401529125506824	NA	NA	0.462507531756592	NA	NA	0.592771794813955	p.Asp375Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.254	-3.286	2.032	3.617	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D375V	375	D	V	missense	low	0.343957488800369	0.177558158323608	4	0.088779079161804	0.169953691062602	0.517961286538135	0.379080773673681	NA	NA	NA	0.456671756532459	0.0833376459621978	NA	0.456739779033136	0.505518327727166	0.4874704460394	NA	NA	NA	0.550713381039227	0.332416587944575	NA	0.523566209414932	p.Asp375Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.254	-3.618	2.364	2.678	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D375W	375	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.254	-5.412	4.158	0.418	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D375X	375	D	X	nonsense	low	0.339588917363845	0.0812648287705109	2	0.0574629114955919	0.226963680385672	0.452214154342018	NA	NA	NA	NA	0.397051828859437	NA	NA	0.282126005868253	0.482154931948393	NA	NA	NA	NA	0.528443082773353	NA	NA	0.435866781123433	p.Asp375Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D375Y	375	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp375Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.254	-4.206	2.952	1.372	NA	85.61	0.001983772	0	0.056699504	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
H376A	376	H	A	missense	wt-like	0.975374839602488	0.246056637713441	7	0.0930006674037831	0.793096880952885	1.15765279825209	0.440807073744695	1.10750241362557	1.05584510197612	1.18669413971555	1.05933722296953	NA	1.0161570645813	0.961280860604647	0.811893609636908	0.516838370209269	0.818763497321225	0.811893609636908	0.816123824663027	0.775831730154044	NA	0.834882753389507	0.776970987293557	p.His376Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.488	-3.167	1.679	4.084	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376C	376	H	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His376Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.488	-5	3.512	0.657	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376D	376	H	D	missense	wt-like	1.08044996808559	0.0914098486101307	4	0.0457049243050654	0.990869962531534	1.17002997363965	NA	NA	NA	NA	0.968991772311373	1.19135996031635	1.06762492440146	1.09382321531319	0.853071565023153	NA	NA	NA	NA	0.742084286779798	0.878530526582066	0.862603002634737	0.84354012741157	p.His376Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.488	-2.177	0.689	33.962	33.962	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
H376E	376	H	E	missense	wt-like	1.30755049851032	0.0510470760914189	3	0.029472043122724	1.24978635543897	1.36531464158167	NA	NA	NA	NA	1.36646353882329	1.27643740408887	1.27975055261882	NA	0.920462875151148	NA	NA	NA	NA	0.890555026983153	0.920462875151148	0.976852464454861	NA	p.His376Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.488	-2.927	1.439	7.848	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376F	376	H	F	missense	wt-like	1.0910006608236	0.258521208040119	5	0.115614198960614	0.864400994759351	1.31760032688785	0.699366547940597	1.27692127628143	0.996418241316025	1.1285554279837	1.35374181059625	NA	NA	NA	0.790627003029261	0.63985489676036	0.896862741760839	0.78274755949734	0.790627003029261	0.885802980257648	NA	NA	NA	p.His376Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.488	-3.908	2.42	1.214	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376G	376	H	G	missense	possibly_wt-like	0.863728595276102	0.255365303878412	7	0.0965190125052453	0.67455480694245	1.05290238360975	1.01391998833777	1.03544791404912	1.06085849869861	0.833679439084585	0.374446070039629	0.690578039128242	NA	1.03717021759476	0.785547585661931	0.789512037627834	0.785547585661931	0.814352442404115	0.661308683632743	0.519998976732088	0.631708793990971	NA	0.815086269386212	p.His376Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.488	-3.223	1.735	4.026	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
H376I	376	H	I	missense	wt-like	0.986105230481294	0.155319961743186	6	0.0634091088565683	0.86182566083064	1.11038480013195	NA	0.997573975383095	1.12884701737034	1.16034898415025	1.00395866222182	NA	0.88176472280888	0.744138020953382	0.765294131697345	NA	0.76808833733858	0.84769757879716	0.804570116086538	0.755145742875591	NA	0.762499926056109	0.667911417994711	p.His376Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.488	-3.923	2.435	1.971	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376K	376	H	K	missense	possibly_wt-like	0.783326821651048	0.23316893182077	8	0.0824376664262452	0.62175196448608	0.944901678816015	0.421468749271582	0.63823443998453	0.974689355821841	1.04985423356151	0.572768420434986	1.01548745942074	0.90268344059493	0.691428474118255	0.698775311716921	0.507637649510874	0.602438859045745	0.772090574102927	0.756112472920611	0.594079876667368	0.791847773971521	0.773766609243368	0.64143815051323	p.His376Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.488	-3.264	1.776	6.572	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376L	376	H	L	missense	wt-like	0.911472950618633	0.163542036412706	7	0.0618130796075841	0.790321540814261	1.03262436042301	NA	1.00652460847594	0.990328256028932	1.01282078847121	0.631491885157702	0.992597917196371	0.71987446833686	1.02667273066341	0.772214428559175	NA	0.772214428559175	0.779760711217703	0.739871398500071	0.616015312110242	0.780566143722903	0.675306904624492	0.80981392697192	p.His376Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.488	-3.486	1.998	3.432	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
H376M	376	H	M	missense	possibly_wt-like	0.850372588188624	0.373304187923968	8	0.131982961363188	0.591690737343835	1.10905443903341	0.429640976307322	1.00442598397224	0.963365655501639	1.01944813131103	0.782075101479534	1.1747200293116	1.25626337465111	0.173041452974513	0.754657333657361	0.511525803241269	0.771246997981894	0.766536837398143	0.742777829916579	0.672263839611211	0.870329159026617	0.964202425583864	0.381079276387589	p.His376Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.488	-4.548	3.06	1.57	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376N	376	H	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His376Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.488	-3.176	1.688	5.939	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
H376P	376	H	P	missense	possibly_wt-like	0.798100725156013	0.238421099932114	8	0.0842945882699766	0.632886368055226	0.963315082256799	1.02048623059732	0.661869671772296	0.545254193310342	0.796364049793086	0.99090636715696	0.530322990915629	0.667350330068401	1.17225196763407	0.645980856467095	0.792636101512069	0.613334303129378	0.561473041236023	0.644943962148234	0.750270216931603	0.552723457294983	0.647017750785955	0.882930815874971	p.His376Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.488	-3.698	2.21	1.975	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
H376Q	376	H	Q	missense	wt-like	0.962442823675529	0.154180197461692	2	0.109021863149843	0.748763898374382	1.17612174897668	NA	1.07146468682537	NA	NA	NA	NA	NA	0.853420960525686	0.762474636909888	NA	0.802150711765384	NA	NA	NA	NA	NA	0.722798562054393	p.His376Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.488	-2.395	0.907	15.554	15.554	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
H376R	376	H	R	missense	wt-like	0.923511053769409	0.14463845659	8	0.0511374167375725	0.823283558701351	1.02373854883747	0.939670128312511	0.8433488078421	0.938832771241551	0.884845525674171	1.00227170583259	1.11080942639485	1.03511794520193	0.633192119655571	0.754345160801906	0.754185697699204	0.696993130643734	0.754504623904608	0.683747649764115	0.754515600850668	0.838829368248568	0.845094958415117	0.612189054639586	p.His376Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.488	-3.418	1.93	5.275	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
H376S	376	H	S	missense	wt-like	1.1265885440715	0.0945268916028729	2	0.0668406060568771	0.995583363495188	1.25759372464781	NA	1.05974793801462	1.19342915012837	NA	NA	NA	NA	NA	0.838060766291256	NA	0.796749487751342	0.879372044831171	NA	NA	NA	NA	NA	p.His376Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.488	-3.204	1.716	4.475	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
H376T	376	H	T	missense	wt-like	1.04716228319359	0.251241583456322	7	0.0949603926890724	0.861043333565226	1.23328123282195	NA	0.717924788382411	0.983595589124303	1.11520624754717	1.18141886368298	1.3111110069123	1.30307869996531	0.717800786740637	0.784772699374976	NA	0.63917476850375	0.776458658156248	0.784772699374976	0.821433841018497	0.937552547046155	0.989416850484005	0.654683593285511	p.His376Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.488	-3.465	1.977	3.027	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376V	376	H	V	missense	wt-like	1.06497524868157	0.183190052670107	7	0.0692393317179896	0.929268652200688	1.20068184516245	0.883458811840386	0.783733160613074	1.02006680148853	1.17707795024036	1.31937912908898	NA	1.13991416345013	1.13119672404953	0.811906629948146	0.727441673227582	0.669511320576204	0.794346054064618	0.811906629948146	0.872967218856204	NA	0.901537509163266	0.862310899556385	p.His376Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.488	-3.618	2.13	2.475	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H376W	376	H	W	missense	possibly_wt-like	0.754484310069603	0.18519183519398	5	0.0828203064743355	0.592159492191336	0.91680912794787	NA	0.552348672043305	0.632565303424952	0.692442024143336	NA	0.986752271778084	NA	0.908313278958337	0.604294990180918	NA	0.562846965444438	0.604294990180918	0.599368797634229	NA	0.777684984740902	NA	0.75036812232953	p.His376Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.488	-5.084	3.596	0.483	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
H376X	376	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His376Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H376Y	376	H	Y	missense	possibly_wt-like	0.726711134164885	0.225079860668371	4	0.112539930334185	0.506136923887235	0.947285344442536	0.431770914281029	0.697363443418955	0.812860068959001	NA	NA	NA	NA	0.964850110000557	0.661208668198565	0.512539177715786	0.629696334513965	0.692721001883165	NA	NA	NA	NA	0.778763635867478	p.His376Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.488	-3.435	1.947	1.434	NA	85.61	0.002359671	0	0.067443313	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y377A	377	Y	A	missense	possibly_low	0.635440967411331	0.144815972212493	8	0.0512001779877881	0.535090462553226	0.735791472269436	0.310211166157479	0.708586321014144	0.625427332149794	0.711974850960511	0.623148843812491	0.707552480678295	0.789038894645185	0.607587849872748	0.610416909754713	0.454703903920116	0.634869892209267	0.600794154592941	0.607934948939021	0.612898870570403	0.640075032658713	0.712558407657058	0.599329359891139	p.Tyr377Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.494	-2.997	1.503	5.449	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377C	377	Y	C	missense	possibly_wt-like	0.721324034328656	0.101588429897928	5	0.0454317269958479	0.632279485661338	0.810368582995974	NA	NA	0.756851140058691	NA	0.810560198318656	0.738148427274138	0.546249392575725	0.754811013416068	0.665251284791274	NA	NA	0.665251284791274	NA	0.682904100804057	0.655154939159999	0.581793585979835	0.673271907721104	p.Tyr377Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.494	-4.739	3.245	0.909	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y377D	377	Y	D	missense	possibly_wt-like	0.72174481208594	0.13117848856145	7	0.0495808082992756	0.624568213494975	0.818921410676905	NA	0.487210617421751	0.719472600479473	0.855492664882576	0.657633040797587	0.883424540866916	0.730858327605476	0.718121892547802	0.65484486805324	NA	0.532819418508633	0.646918888016168	0.670874907425139	0.625780022599454	0.726757568056822	0.681222738654983	0.65484486805324	p.Tyr377Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.494	-3.514	2.02	2.628	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y377E	377	Y	E	missense	possibly_low	0.626764129426367	0.2554988562127	7	0.0965694905428934	0.437491405956914	0.816036852895819	0.35831459265157	0.870276089882571	0.72288857237297	0.731542696406442	0.761268472621293	0.176733423251259	NA	0.766325058798461	0.6485942598426	0.477590384722692	0.70940615449011	0.6485942598426	0.616516457717426	0.664491776667397	0.378448815930136	NA	0.679054814642225	p.Tyr377Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.494	-3.328	1.834	3.765	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377F	377	Y	F	missense	possibly_wt-like	0.804013881018995	0.19124222053036	8	0.0676143354930953	0.67149221861392	0.93653554342407	0.514207641695084	0.762909212751434	0.903084450485824	1.05942853343005	0.797000106720348	0.589884380185235	1.02500485183095	0.780591871053032	0.682029593511133	0.551760636911022	0.659911831069847	0.736971771965628	0.760311296883931	0.67783889364609	0.582079639443448	0.839648113143848	0.686220293376176	p.Tyr377Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.494	-3.162	1.668	2.232	NA	72.21	0.003755377	0	0.107334937	2.076e-05	5	240854	PTEN hamartoma tumor syndrome|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Dec 8, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
Y377G	377	Y	G	missense	possibly_low	0.671625627171537	0.239954994778153	7	0.0906944631472566	0.493867745805719	0.849383508537355	0.805090023519983	0.687206131447226	0.639725723795502	0.964629278204458	0.627630538551307	NA	0.1956526420867	0.781445052595582	0.625013984638079	0.690155643933257	0.625013984638079	0.607806835983006	0.718736937399515	0.614572953087199	NA	0.392964492598379	0.686648802148161	p.Tyr377Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.494	-3.232	1.738	3.342	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377H	377	Y	H	missense	possibly_wt-like	0.876975887139864	0.189182667755762	4	0.094591333877881	0.691580279489614	1.06237149479011	NA	NA	0.978860041214298	0.7940952589078	1.07953555276326	NA	NA	0.6554126956741	0.709042538716049	NA	NA	0.774136097023281	0.643948980408816	0.783376570386756	NA	NA	0.623349295769549	p.Tyr377His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.494	-2.364	0.87	25.564	25.564	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
Y377I	377	Y	I	missense	low	0.585582550247302	0.105312523005983	7	0.0398043922592286	0.507567374992709	0.663597725501895	0.3944073060263	0.732671647425549	0.532716363148684	0.618750064088613	0.627123599070185	NA	0.632011796159188	0.561397075812595	0.576130133369689	0.494762450248318	0.645972822339503	0.555323831560903	0.567051074977698	0.614383592014686	NA	0.627984649908098	0.576130133369689	p.Tyr377Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.494	-3.583	2.089	1.6	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377K	377	Y	K	missense	possibly_low	0.623952215102894	0.227965037214912	6	0.0930663367285186	0.441545546941921	0.806358883263868	NA	0.723234949389298	0.664690487580395	0.943905454283179	0.485921109823279	NA	0.26923174981506	0.656729539726154	0.622030771994467	NA	0.641622663360258	0.620050865852913	0.709648472479145	0.561639120926785	NA	0.432593713875482	0.62401067813602	p.Tyr377Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.494	-3.403	1.909	3.271	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377L	377	Y	L	missense	low	0.560034487445999	0.12709680723957	8	0.0449355071331297	0.471962511838023	0.648106463053976	0.388118492570651	0.727622833127144	0.578597682163091	0.609209433218029	0.451888557544579	0.426837479537079	0.588154611198804	0.70984681020862	0.570346727026003	0.491770380474632	0.643645403917256	0.577826437446686	0.56286701660532	0.548926675280217	0.501718274927517	0.60436345985776	0.650688724027156	p.Tyr377Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.494	-3.155	1.661	2.719	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y377M	377	Y	M	missense	low	0.239585593386977	0.0710797669361082	3	0.041037922574498	0.159152743140617	0.320018443633336	NA	0.173219182513733	NA	NA	0.230948254846453	NA	NA	0.314589342800744	0.452171429020397	NA	0.388074651353409	NA	NA	0.466397114576537	NA	NA	0.452171429020397	p.Tyr377Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.494	-4.414	2.92	1.054	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377N	377	Y	N	missense	low	0.549942560590348	0.100580154143298	7	0.0380157249559583	0.475433108830489	0.624452012350206	NA	0.711202032275884	0.460086418765056	0.542055465662843	0.557416960260315	0.577839895448999	0.398435576805704	0.602561574913632	0.576143241852034	NA	0.636075691079662	0.519702296498714	0.533416540635858	0.588345525582918	0.576143241852034	0.50218204142851	0.596804923059148	p.Tyr377Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.494	-3.43	1.936	3.939	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y377P	377	Y	P	missense	possibly_low	0.540093101707346	0.244490232314406	7	0.0924086218126179	0.358975531093633	0.72121067232106	0.655377218974632	0.714202919899306	0.749925709227264	0.482716271194413	0.0460580615280448	0.671765324902884	NA	0.46060620622488	0.618925806957964	0.618925806957964	0.637459049770444	0.661854690187271	0.507393245447772	0.397333633416039	0.622436520924828	NA	0.525508114959384	p.Tyr377Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.494	-3.826	2.332	1.452	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377Q	377	Y	Q	missense	possibly_wt-like	0.711269621486952	0.0686584328138981	4	0.034329216406949	0.643985593711851	0.778553649262054	NA	0.812040995406568	0.662493328550502	0.673953944843835	NA	NA	NA	0.696590217146905	0.631501944858243	NA	0.68256075600763	0.618973263796561	0.591260821963483	NA	NA	NA	0.644030625919925	p.Tyr377Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.494	-3.681	2.187	2.889	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377R	377	Y	R	missense	low	0.584063294772053	0.126575482653771	8	0.0447511910582208	0.49635257203267	0.671774017511437	0.506769777938723	0.682940055003816	0.842689758898814	0.484733470013992	0.505578053556784	0.522390625443991	0.630230180376106	0.497174436944202	0.558897771986851	0.548221875985269	0.623047395193852	0.707351046764829	0.508277891099018	0.568981732986658	0.548813810987044	0.627025083418664	0.543874437784834	p.Tyr377Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.494	-3.654	2.16	3.418	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377S	377	Y	S	missense	low	0.58185464984019	0.0948355086764794	5	0.0424117288162758	0.49872918883821	0.66498011084217	NA	0.649652560611465	0.440162969900744	0.619795407383887	NA	0.5319481852207	NA	0.667714126084155	0.56750951189093	NA	0.607702420492828	0.509930791945011	0.56750951189093	NA	0.553524471183868	NA	0.629527665290897	p.Tyr377Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.494	-2.242	0.748	10.969	10.969	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
Y377T	377	Y	T	missense	possibly_wt-like	0.755660210399818	0.127442084120195	7	0.0481685801636873	0.66125152809256	0.850068892707075	NA	0.729595267154436	0.836616277181774	0.679460387469931	0.698579649712925	1.00660998565393	0.628841797991152	0.709918107634579	0.644554662808643	NA	0.644554662808643	0.704372292701761	0.593675680863723	0.641075129942117	0.787472309595812	0.626277309839326	0.65072453302081	p.Tyr377Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.494	-3.341	1.847	4.097	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377V	377	Y	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr377Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.494	-3.326	1.832	2.056	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y377W	377	Y	W	missense	wt-like	0.823493362377209	0.109474020755797	4	0.0547370103778987	0.716210793415132	0.930775931339286	NA	NA	NA	NA	0.775017384628486	0.982728910178453	0.800624824481409	0.735602330220488	0.694213014154012	NA	NA	NA	NA	0.66962751539071	0.775701979686516	0.718798512917314	0.663624383909256	p.Tyr377Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.494	-4.417	2.923	0.418	NA	72.21	0.003755377	0	0.107334937	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y377X	377	Y	X	nonsense	low	0.0644760573331717	0.225162509792108	2	0.159213937542982	-0.247577526087882	0.376529640754225	NA	-0.09473788020981	0.223689994876154	NA	NA	NA	NA	NA	0.334156021676155	NA	0.264550955037046	0.403761088315264	NA	NA	NA	NA	NA	p.Tyr377Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R378A	378	R	A	missense	possibly_wt-like	0.844338612053512	0.191202438766151	7	0.0722677290063274	0.70269646595661	0.985980758150414	NA	0.591859898830409	0.622530427538824	0.775383047950165	0.843481111787161	1.05938455054472	1.03403731603891	0.983693931684393	0.695201307304366	NA	0.581060976036771	0.599373360593342	0.635742711453963	0.695201307304366	0.813483451356246	0.844512938687755	0.788227908693992	p.Arg378Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-4.5	1.8	-6.3	265	121	144	10.5	8.1	2.4	174	89	85	6.34	6	-0.34	-1.565	-3.06	1.495	3.334	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R378C	378	R	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	180	-4.5	2.5	-7	265	148	117	10.5	5.5	5	174	121	53	6.34	5.07	-1.27	-1.565	-4.976	3.411	0.692	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R378D	378	R	D	missense	possibly_low	0.500823007990805	0.474219523397659	3	0.273790769488615	-0.0357970395063881	1.037443055488	NA	-0.00529562019220404	NA	NA	0.572865452630549	NA	NA	0.934899191534068	0.594116121862908	NA	0.305782331631372	NA	NA	0.594116121862908	NA	NA	0.763720845263349	p.Arg378Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	-3.5	-1	265	187	78	10.5	13	-2.5	174	133	41	6.34	5.05	-1.29	-1.565	-2.157	0.592	19.787	19.787	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R378E	378	R	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-4.5	-3.5	-1	265	214	51	10.5	12.3	-1.8	174	147	27	6.34	3.22	-3.12	-1.565	-2.984	1.419	4.572	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
R378F	378	R	F	missense	possibly_wt-like	0.899720401504563	0.424208137969996	2	0.299960450993103	0.31180872077169	1.48763208223744	NA	NA	0.59975995051146	1.19968085249767	NA	NA	NA	NA	0.705012345817781	NA	NA	0.588205524066734	0.821819167568829	NA	NA	NA	NA	p.Arg378Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	2.8	-7.3	265	228	37	10.5	5.2	5.3	174	165	9	6.34	3.32	-3.02	-1.565	-4.061	2.496	2.44	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R378G	378	R	G	missense	possibly_wt-like	0.715501327225953	0.196809513317413	8	0.0695826707343834	0.579121798638453	0.851880855813454	0.992922183519525	0.857622285431164	0.6164635163765	0.771144309120253	0.642231765393053	0.340809318337487	0.671623387761183	0.831193851868464	0.641601498717025	0.779521775147715	0.70357296359596	0.596397829075014	0.633883806007333	0.620027063642259	0.459317343702738	0.649319191426717	0.711635039919339	p.Arg378Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	125	-4.5	-9.4	4.9	265	97	168	10.5	9	1.5	174	75	99	6.34	3.29	-3.05	-1.565	-3.192	1.627	2.884	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
R378H	378	R	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-4.5	-3.2	-1.3	265	216	49	10.5	10.4	0.0999999999999996	174	155	19	6.34	7.59	1.25	-1.565	-2.42	0.855	27.936	27.936	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
R378I	378	R	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-4.5	4.5	-9	265	191	74	10.5	5.2	5.3	174	131	43	6.34	6.02	-0.32	-1.565	-3.899	2.334	1.749	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
R378K	378	R	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-4.5	-3.9	-0.6	265	230	35	10.5	11.3	-0.800000000000001	174	146	28	6.34	9.74	3.4	-1.565	-2.916	1.351	3.574	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
R378L	378	R	L	missense	possibly_wt-like	0.73556954963367	0.153440117866924	7	0.0579949132880457	0.621901608302577	0.849237490964763	NA	0.6193438712505	0.804323577702044	0.837348547502773	0.506499315040721	0.959475365075356	0.64446151933308	0.77753465153122	0.662917776784394	NA	0.593730624779298	0.688534258726491	0.662917776784394	0.569325859000038	0.764240942359899	0.634689988552843	0.684684810811629	p.Arg378Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-4.5	3.8	-8.3	265	191	74	10.5	4.9	5.6	174	131	43	6.34	9.71	3.37	-1.565	-3.38	1.815	2.971	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R378M	378	R	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-4.5	1.9	-6.4	265	203	62	10.5	5.7	4.8	174	149	25	6.34	5.74	-0.6	-1.565	-4.502	2.937	1.152	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R378N	378	R	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-4.5	-3.5	-1	265	187	78	10.5	11.6	-1.1	174	132	42	6.34	5.47	-0.87	-1.565	-3.23	1.665	4.305	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
R378P	378	R	P	missense	low	0.640290360820678	0.0916077764064967	8	0.0323882399532274	0.576810576989711	0.703770144651645	0.621497275418728	0.747763630873558	0.590840408787009	0.563628837051047	0.729456474338434	0.696196799537195	0.482430132443315	0.690509328116139	0.618642326450941	0.602806525353777	0.65292997271761	0.583830912865079	0.542877575907176	0.65260879193655	0.634478127548105	0.547420954133507	0.6409765112196	p.Arg378Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-4.5	-1.6	-2.9	265	154	111	10.5	8	2.5	174	115	59	6.34	6.3	-0.04	-1.565	-3.713	2.148	1.438	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
R378Q	378	R	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-4.5	-3.5	-1	265	214	51	10.5	10.5	0	174	146	28	6.34	6.24	-0.1	-1.565	-3.431	1.866	3.157	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R378R	378	R	R	synonymous	wt-like	1.00490873984676	0.120811141060427	5	0.0540283847700864	0.899015051554519	1.110802428139	0.9389172796548	NA	NA	NA	1.10561269462746	1.07788402704986	0.823077650031279	1.0790520478704	0.793117369309263	0.75382750998561	NA	NA	NA	0.793117369309263	0.822601338104624	0.730891456410145	0.836121337264316	p.Arg378=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-4.5	-4.5	0	265	265	0	10.5	10.5	0	174	174	0	6.34	6.34	0	NA	NA	NA	NA	NA	NA	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
R378S	378	R	S	missense	wt-like	0.861189071013115	0.184700734332108	7	0.0698103157162523	0.72436336645989	0.99801477556634	NA	0.955883670094323	0.973016425361804	1.01203981529145	1.01222750974921	0.511667495459086	0.819539185846616	0.743949395289313	0.739528901508448	NA	0.748869808229908	0.771270081239487	0.739528901508448	0.758234470217898	0.543528673066341	0.728985662979314	0.667816681121439	p.Arg378Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-4.5	-0.8	-3.7	265	143	122	10.5	9.2	1.3	174	105	69	6.34	5.68	-0.66	-1.565	-3.219	1.654	3.327	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	T	D	B	0.428571428571429
R378T	378	R	T	missense	wt-like	0.87666435757133	0.160465982401013	6	0.0655099629928178	0.748267189476855	1.0050615256658	NA	0.779278623626623	0.993814274039796	1.06752684675731	0.927658870875127	0.872910486739946	0.618797043389179	NA	0.72411018124234	NA	0.667457853993343	0.781470437334875	0.763862824674774	0.726644884568049	0.72157547791663	0.62086727137752	NA	p.Arg378Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-4.5	-0.7	-3.8	265	163	102	10.5	8.6	1.9	174	119	55	6.34	5.6	-0.74	-1.565	-3.356	1.791	2.239	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
R378V	378	R	V	missense	possibly_wt-like	0.785305080045362	0.276265901324099	8	0.0976747461184421	0.593866095454122	0.976744064636602	0.73819431780572	0.943936735805476	0.676291964849077	0.854678998250902	1.14575272146304	0.202367789657922	0.928063290024392	0.793154822506374	0.681524042001581	0.65832823794187	0.743362472584384	0.625740838946059	0.67051807266979	0.808111187734053	0.391083295057011	0.787436028458573	0.692530011333371	p.Arg378Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-4.5	4.2	-8.7	265	165	100	10.5	5.9	4.6	174	117	57	6.34	5.61	-0.73	-1.565	-3.642	2.077	1.953	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
R378W	378	R	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Arg378Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-4.5	-0.9	-3.6	265	264	1	10.5	5.4	5.1	174	204	-30	6.34	5.89	-0.45	-1.565	-5.2	3.635	0.457	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
R378X	378	R	X	nonsense	low	0.379373648050321	0.214224418390214	5	0.0958040723921749	0.19160111658939	0.567146179511252	0.53081577935543	0.00595302582176835	0.398197748209356	NA	0.470937714339136	NA	NA	0.490963972525915	0.540755244097896	0.559662398831802	0.310967768134062	0.489348845634045	NA	0.556042255927259	NA	NA	0.540755244097896	p.Arg378Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-4.5	NA	NA	265	NA	NA	10.5	NA	NA	174	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
R378Y	378	R	Y	missense	possibly_low	0.201114694818465	0.617707338763908	2	0.436785048028655	-0.654968268303297	1.05719765794023	NA	NA	NA	NA	-0.235670353210191	NA	NA	0.63789974284712	0.453325431318105	NA	NA	NA	NA	0.292097413395742	NA	NA	0.614553449240468	p.Arg378Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-4.5	-1.3	-3.2	265	255	10	10.5	6.2	4.3	174	181	-7	6.34	5.66	-0.68	-1.565	-3.804	2.239	4.58	NA	78.91	0.006241563	0	0.178394254	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Y379A	379	Y	A	missense	possibly_low	0.635055121822261	0.205084985194755	8	0.0725084918753769	0.492941089173207	0.777169154471315	0.945470475019998	0.678816002087953	0.607828280123283	0.591581130104635	0.627492609746375	0.473205965400081	0.86153459145458	0.294511920641185	0.60334204382641	0.75694536646387	0.621146276205631	0.592162656191781	0.555136097106085	0.614521431461038	0.524572035285277	0.751604110971423	0.44208758275188	p.Tyr379Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-1.3	1.8	-3.1	255	121	134	6.2	8.1	-1.9	181	89	92	5.66	6	0.34	-1.265	-3.043	1.778	3.912	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y379C	379	Y	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	194	-1.3	2.5	-3.8	255	148	107	6.2	5.5	0.7	181	121	60	5.66	5.07	-0.59	-1.265	-4.783	3.518	0.518	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y379D	379	Y	D	missense	possibly_low	0.648604743030061	0.122200025082982	5	0.0546495125875456	0.541493666585803	0.755715819474319	NA	0.456291217384684	0.74956621746255	NA	0.728536242734303	NA	0.599090866857718	0.709539170711049	0.650534212687255	NA	0.518566095451412	0.661678376566078	NA	0.652265050622235	NA	0.610253654898587	0.650534212687255	p.Tyr379Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-1.3	-3.5	2.2	255	187	68	6.2	13	-6.8	181	133	48	5.66	5.05	-0.61	-1.265	-3.659	2.394	1.697	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.714285714285714
Y379E	379	Y	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-1.3	-3.5	2.2	255	214	41	6.2	12.3	-6.1	181	147	34	5.66	3.22	-2.44	-1.265	-3.535	2.27	1.304	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379F	379	Y	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	-1.3	2.8	-4.1	255	228	27	6.2	5.2	1	181	165	16	5.66	3.32	-2.34	-1.265	-3.012	1.747	0.806	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
Y379G	379	Y	G	missense	possibly_low	0.670482148020613	0.177544906500908	8	0.0627716036759617	0.547452065563906	0.79351223047732	0.74084777810968	0.94742167968417	0.765294908026203	0.769110503261896	0.38508425801276	0.690342456678476	0.515918758417184	0.54983684197454	0.632292279574439	0.65959069204822	0.744968973062394	0.669392551582324	0.632991877313636	0.52397274235739	0.631592681835242	0.565457706819936	0.570324028386458	p.Tyr379Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.3	-9.4	8.1	255	97	158	6.2	9	-2.8	181	75	106	5.66	3.29	-2.37	-1.265	-1.969	0.704	25.43	25.43	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379H	379	Y	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	83	-1.3	-3.2	1.9	255	216	39	6.2	10.4	-4.2	181	155	26	5.66	7.59	1.93	-1.265	-3.807	2.542	0.645	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y379I	379	Y	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	-1.3	4.5	-5.8	255	191	64	6.2	5.2	1	181	131	50	5.66	6.02	0.36	-1.265	-3.558	2.293	0.932	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379K	379	Y	K	missense	low	0.572014443771202	0.112514431164646	3	0.0649602371206262	0.444694718587593	0.699334168954812	NA	0.44482775904089	0.612647872356293	0.658567699916424	NA	NA	NA	NA	0.584513160537185	NA	0.513281634079871	0.59452643706991	0.584513160537185	NA	NA	NA	NA	p.Tyr379Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-1.3	-3.9	2.6	255	230	25	6.2	11.3	-5.1	181	146	35	5.66	9.74	4.08	-1.265	-3.552	2.287	1.708	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379L	379	Y	L	missense	possibly_low	0.645437109261358	0.241206960746768	6	0.098472329372852	0.452434890216803	0.838439328305914	0.919291126249611	0.729040789764328	0.63630296631096	0.549183999963136	0.229746450604582	NA	NA	0.809057322675535	0.625213597105075	0.744489847039885	0.644299058063413	0.606128136146738	0.536542770339795	0.465948195230803	NA	NA	0.700517011144227	p.Tyr379Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	3.8	-5.1	255	191	64	6.2	4.9	1.3	181	131	50	5.66	9.71	4.05	-1.265	-3.131	1.866	1.403	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y379M	379	Y	M	missense	possibly_wt-like	0.887965529717116	0.321914290625796	5	0.143964447353581	0.605800397849885	1.17013066158435	1.34387193922343	0.665870307370658	0.854380760579183	1.04877860729241	NA	NA	NA	0.526926034119901	0.713084927326126	0.946495428211141	0.615178528811291	0.713084927326126	0.755640755362532	NA	NA	NA	0.558817119657953	p.Tyr379Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	36	-1.3	1.9	-3.2	255	203	52	6.2	5.7	0.5	181	149	32	5.66	5.74	0.08	-1.265	-4.443	3.178	0.493	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379N	379	Y	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-1.3	-3.5	2.2	255	187	68	6.2	11.6	-5.4	181	132	49	5.66	5.47	-0.19	-1.265	-3.638	2.373	1.923	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y379P	379	Y	P	missense	possibly_low	0.534272144209835	0.387622671326706	5	0.173350128541315	0.194512135553469	0.8740321528662	NA	0.887367940411955	0.56661935029695	0.687312368742345	-0.126682983876888	NA	NA	0.656744045474811	0.597119179352266	NA	0.71728520993585	0.571951635088275	0.597119179352266	0.332808318574581	NA	NA	0.624017963620098	p.Tyr379Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.3	-1.6	0.3	255	154	101	6.2	8	-1.8	181	115	66	5.66	6.3	0.64	-1.265	-3.915	2.65	0.918	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379Q	379	Y	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-1.3	-3.5	2.2	255	214	41	6.2	10.5	-4.3	181	146	35	5.66	6.24	0.58	-1.265	-3.82	2.555	0.92	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379R	379	Y	R	missense	possibly_low	0.645899045810262	0.113550274968833	8	0.0401460847180294	0.56721416564263	0.724583925977893	0.674831572952596	0.801299636221446	0.80899298639208	0.564843754949355	0.540092893295252	0.502544650704784	0.627142356893624	0.647444515072958	0.622354647318834	0.628181731770262	0.677609170195626	0.690824381716166	0.543410380023919	0.581874331243236	0.539032272031986	0.625362002092595	0.619347292545074	p.Tyr379Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.3	-4.5	3.2	255	265	-10	6.2	10.5	-4.3	181	174	7	5.66	6.34	0.68	-1.265	-3.803	2.538	1.158	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379S	379	Y	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-1.3	-0.8	-0.5	255	143	112	6.2	9.2	-3	181	105	76	5.66	5.68	0.02	-1.265	-3.351	2.086	2.579	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
Y379T	379	Y	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-1.3	-0.7	-0.6	255	163	92	6.2	8.6	-2.4	181	119	62	5.66	5.6	-0.06	-1.265	-3.517	2.252	1.47	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379V	379	Y	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	-1.3	4.2	-5.5	255	165	90	6.2	5.9	0.3	181	117	64	5.66	5.61	-0.05	-1.265	-3.267	2.002	1.225	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
Y379W	379	Y	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	37	-1.3	-0.9	-0.4	255	264	-9	6.2	5.4	0.8	181	204	-23	5.66	5.89	0.23	-1.265	-4.224	2.959	0.274	NA	49.88	0.00602003	0	0.172062492	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Y379X	379	Y	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Tyr379Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.3	NA	NA	255	NA	NA	6.2	NA	NA	181	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S380A	380	S	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Ala	1	0	yes	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.515	-2.65	1.135	3.912	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
S380C	380	S	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.515	-4.61	3.095	1.145	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S380D	380	S	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.515	-3.326	1.811	1.697	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S380E	380	S	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.515	-3.313	1.798	1.462	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S380F	380	S	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.515	-3.877	2.362	3.953	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S380G	380	S	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.515	-1.918	0.403	25.43	25.43	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S380H	380	S	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.515	-4.477	2.962	0.721	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S380I	380	S	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.515	-3.455	1.94	8.31	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S380K	380	S	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.515	-3.296	1.781	1.798	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S380L	380	S	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.515	-2.157	0.642	27.115	27.115	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
S380M	380	S	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.515	-4.243	2.728	3.599	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S380N	380	S	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.515	-3.306	1.791	1.923	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S380P	380	S	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.515	-3.677	2.162	1.033	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
S380Q	380	S	Q	missense	low	0.301335341250576	0.300122134803979	6	0.122524348464089	0.0611920310317257	0.541478651469427	NA	0.826242551828363	0.295849332029521	-0.0366298881526285	0.283052874843168	0.0665473129228431	NA	0.372949864032192	0.460317350157486	NA	0.689107434512146	0.439151812902579	0.27963318684642	0.485860161139103	0.324141091333749	NA	0.481482887412393	p.Ser380Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.515	-3.738	2.223	1.181	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S380R	380	S	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.515	-3.69	2.175	1.766	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S380T	380	S	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.515	-3.07	1.555	2.427	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
S380V	380	S	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.515	-3.26	1.745	6.92	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S380W	380	S	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.515	-5.104	3.589	0.534	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
S380X	380	S	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S380Y	380	S	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ser380Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.515	-4.04	2.525	1.613	NA	72.21	0.005766693	0	0.164821691	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D381A	381	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.154	-3.113	1.959	4.155	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D381C	381	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.154	-4.958	3.804	0.622	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D381E	381	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.154	-2.686	1.532	5.131	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D381F	381	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.154	-4.162	3.008	1.178	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381G	381	D	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.154	-3.054	1.9	3.153	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D381H	381	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.154	-4.325	3.171	1.474	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D381I	381	D	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.154	-3.881	2.727	1.944	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381K	381	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.154	-2.136	0.982	20.007	20.007	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381L	381	D	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.154	-3.549	2.395	3.059	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381M	381	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.154	-4.67	3.516	1.128	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381N	381	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.154	-3.144	1.99	3.03	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D381P	381	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.154	-3.525	2.371	1.958	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381Q	381	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.154	-3.485	2.331	3.845	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D381R	381	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.154	-3.499	2.345	7.74	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D381S	381	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.154	-3.031	1.877	3.851	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D381T	381	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.154	-3.292	2.138	2.914	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D381V	381	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.154	-3.564	2.41	2.404	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D381W	381	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.154	-5.358	4.204	0.338	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D381X	381	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D381Y	381	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp381Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.154	-4.198	3.044	1.241	NA	72.21	0.005545908	0	0.158511287	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
T382A	382	T	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.342	-2.035	0.693	12.291	12.291	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
T382C	382	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.342	-4.502	3.16	0.909	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T382D	382	T	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.342	-3.499	2.157	1.239	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T382E	382	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.342	-3.426	2.084	1.708	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T382F	382	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.342	-3.874	2.532	2.237	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T382G	382	T	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.342	-3.232	1.89	3.325	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
T382H	382	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.342	-4.633	3.291	0.633	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T382I	382	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.342	-2.344	1.002	13.543	13.543	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T382K	382	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.342	-3.443	2.101	1.913	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T382L	382	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.342	-2.873	1.531	8.359	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
T382M	382	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.342	-4.287	2.945	1.842	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T382N	382	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.342	-3.544	2.202	1.114	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T382P	382	T	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.342	-3.641	2.299	1.233	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T382Q	382	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.342	-3.886	2.544	1.1	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T382R	382	T	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.342	-3.695	2.353	1.342	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T382S	382	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.342	-2.95	1.608	3.575	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	neutral	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
T382V	382	T	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.342	-2.818	1.476	8.792	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T382W	382	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.342	-5.093	3.751	0.266	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
T382X	382	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T382Y	382	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr382Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.342	-4.027	2.685	1.015	NA	42.43	0.005589798	0	0.159765742	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T383A	383	T	A	missense	low	0.441354938060279	0.254729351236134	6	0.103992822173121	0.237532751950284	0.645177124170273	0.585687243026323	0.39714711106814	0.503621790832833	0.751689840350237	-0.00682072228833291	NA	NA	0.416804365372471	0.52228152621388	0.585768952801869	0.49130165780871	0.541054326928016	0.625352018744888	0.377581407382053	NA	NA	0.503508725499744	p.Thr383Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.204	-2.663	1.459	5.449	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T383C	383	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.204	-4.508	3.304	0.909	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383D	383	T	D	missense	possibly_wt-like	0.741912693730204	0.199047984864701	5	0.089016964988364	0.567442648339948	0.916382739120461	0.899360883071367	NA	0.709902612101706	NA	NA	0.945202150655428	0.440968689034835	0.714129133787685	0.652839512724039	0.735007505320515	NA	0.642225263651777	NA	NA	0.757206064774038	0.525090094654092	0.652839512724039	p.Thr383Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.204	-3.279	2.075	2.443	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383E	383	T	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.204	-3.25	2.046	2.574	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T383F	383	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.204	-3.937	2.733	1.041	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383G	383	T	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.204	-3.099	1.895	3.342	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T383H	383	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.204	-4.491	3.287	0.963	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383I	383	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.204	-3.481	2.277	1.501	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T383K	383	T	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.204	-3.267	2.063	2.703	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383L	383	T	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.204	-3.054	1.85	2.116	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383M	383	T	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.204	-4.35	3.146	0.746	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T383N	383	T	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.204	-3.259	2.055	2.742	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
T383P	383	T	P	missense	low	0.568739468291343	0.148241380811675	8	0.0524112428121963	0.466015319994455	0.671463616588232	0.779316816080358	0.446377489519544	0.4613397619486	0.772247977305571	0.507838490561658	0.455653350900013	0.675401245372109	0.451740614642891	0.545440740264205	0.677893357017786	0.51399603374925	0.520317001749234	0.634367821390985	0.569826091714931	0.515920830960385	0.651353920575235	0.521055388813479	p.Thr383Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.204	-3.525	2.321	1.452	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
T383Q	383	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.204	-3.71	2.506	1.65	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T383R	383	T	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.204	-3.578	2.374	1.975	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383S	383	T	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.204	-2.026	0.822	10.969	10.969	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000615027676245431	7.24397715042636e-05	7.24397715042636e-05	0.00052350138763724	0.000121217123079224	0.000324245667497931	0.000127737279254014	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T383V	383	T	V	missense	low	0.109774458929604	0.136321338371036	2	0.0963937427825852	-0.0791538052592806	0.298702723118489	NA	0.013380716147019	NA	NA	0.206168201712189	NA	NA	NA	0.385766317864846	NA	0.31439180836925	NA	NA	0.457140827360443	NA	NA	NA	p.Thr383Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.204	-3.042	1.838	2.056	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T383W	383	T	W	missense	possibly_wt-like	0.760595678969766	0.239035679209232	3	0.138007313737375	0.490106314441391	1.03108504349814	NA	1.03621909860204	0.610061789793198	0.635506148514063	NA	NA	NA	NA	0.593258086509039	NA	0.785903088762132	0.593258086509039	0.574399481627066	NA	NA	NA	NA	p.Thr383Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.204	-5.018	3.814	0.25	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
T383X	383	T	X	nonsense	possibly_low	0.439970764057514	0.432227309193981	5	0.193297929017912	0.061113784896227	0.818827743218802	NA	-0.00118934117209265	0.396508996445726	NA	0.249734465877782	1.15612402289216	NA	0.398675676243996	0.4885205931733	NA	0.307675257152779	0.4885205931733	NA	0.4734144750344	0.861163695319715	NA	0.494403626609634	p.Thr383Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T383Y	383	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr383Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.204	-4.033	2.829	0.898	NA	49.88	0.004868254	0	0.139142818	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D384A	384	D	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.352	-3.137	1.785	3.153	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D384C	384	D	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.352	-5.021	3.669	0.709	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384E	384	D	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.352	-2.003	0.651	14.816	14.816	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D384F	384	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.352	-4.18	2.828	1.213	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384G	384	D	G	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.352	-3.01	1.658	4.624	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D384H	384	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.352	-4.176	2.824	2.313	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D384I	384	D	I	missense	possibly_low	0.686483658174414	0.154126274666154	5	0.0689273654544647	0.551388504334433	0.821578812014395	NA	0.809043360616352	0.74581120998626	0.791396081977423	NA	0.653413667256719	0.432753971035316	NA	0.64276525220601	NA	0.681178896818212	0.659836723903246	0.64276525220601	NA	0.613391490055106	0.520665701815111	NA	p.Asp384Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.352	-3.899	2.547	1.608	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384K	384	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.352	-3.178	1.826	3.947	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384L	384	D	L	missense	possibly_low	0.680044012807859	0.150528667816672	6	0.0614530713019592	0.559598206316647	0.800489819299071	NA	0.770540753298628	0.810245877325917	NA	0.731337230384792	0.789774916117484	0.471515893411464	0.506849406308869	0.658370584145516	NA	0.663429842826642	0.691438865159704	NA	0.653311325464391	0.680600225590622	0.541542617102549	0.54873367234944	p.Asp384Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.352	-3.59	2.238	2.214	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384M	384	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.352	-4.712	3.36	0.856	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384N	384	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.352	-2.135	0.783	22.87	22.87	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	1	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
D384P	384	D	P	missense	low	0.447725590345657	0.112034425340608	2	0.0792203018846818	0.29245665180729	0.602994528884024	NA	0.368505288460975	0.526945892230338	NA	NA	NA	NA	NA	0.515295974753109	NA	0.47809825961605	0.552493689890169	NA	NA	NA	NA	NA	p.Asp384Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.352	-3.589	2.237	1.391	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D384Q	384	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.352	-3.444	2.092	3.25	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D384R	384	D	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.352	-3.596	2.244	3.2	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384S	384	D	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.352	-2.994	1.642	5.089	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D384T	384	D	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.352	-3.255	1.903	3.617	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D384V	384	D	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.352	-3.587	2.235	1.943	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
D384W	384	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.352	-5.381	4.029	0.261	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D384X	384	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp384Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D384Y	384	D	Y	missense	possibly_low	0.541342614845519	0.284992024379099	5	0.127452307911388	0.291540681592689	0.79114454809835	NA	0.704576155662939	0.286589480909812	0.199004017123696	0.653330566353241	NA	NA	0.863212854177909	0.624172885642121	NA	0.633021273471675	0.434610296120064	0.382970799165872	0.624172885642121	NA	NA	0.727716521615236	p.Asp384Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.352	-4.17	2.818	1.133	NA	72.21	0.004500965	0	0.128645083	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
S385A	385	S	A	missense	low	0.557347999190338	0.198205176996188	8	0.0700761123601422	0.420001342787877	0.694694655592799	0.39894451739817	0.821334748703138	0.406427635280936	0.544873131736878	0.261802317278386	0.807351353296566	0.576669172881554	0.641381116947076	0.566414855550448	0.496921148880156	0.68684501986758	0.493385214013038	0.534652232435232	0.477922274030629	0.689263171463403	0.598177478665664	0.616301962617741	p.Ser385Ala	1	0	no	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-0.8	1.8	-2.6	143	121	22	9.2	8.1	1.1	105	89	16	5.68	6	0.32	-1.267	-2.548	1.281	3.644	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S385C	385	S	C	missense	low	0.542808893068705	0.137384776960438	8	0.0485728537102635	0.447607849170256	0.638009936967154	0.624718271509219	0.308209040799245	0.688551518421159	0.649874450426874	0.378706224343539	0.636911853327317	0.554519794039722	0.500979991682568	0.583474346070163	0.604338999660971	0.450302704203248	0.631753567182612	0.58070072257545	0.521590305516099	0.605258196634114	0.586247969564876	0.545785770257855	p.Ser385Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	112	-0.8	2.5	-3.3	143	148	-5	9.2	5.5	3.7	105	121	-16	5.68	5.07	-0.61	-1.267	-4.508	3.241	0.912	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S385D	385	S	D	missense	wt-like	0.921592648174108	0.191236802385206	7	0.0722807172334942	0.779925045619736	1.06326025072848	0.730052299006182	0.971450188705637	1.10661109068103	1.13086527355314	0.828468324218401	1.04289675670196	NA	0.640804604352402	0.756045711332081	0.654454456580936	0.756045711332081	0.836791913800093	0.791639989363687	0.689593463249403	0.805357068053073	NA	0.61601241028725	p.Ser385Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.8	-3.5	2.7	143	187	-44	9.2	13	-3.8	105	133	-28	5.68	5.05	-0.63	-1.267	-3.164	1.897	1.858	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S385E	385	S	E	missense	wt-like	0.907289295950946	0.116329236331013	8	0.0411285959299557	0.826678729193532	0.98789986270836	0.991001267208797	0.961372339309314	0.863989926067632	0.672988582488009	0.943398941384802	1.03511213874888	0.824199333008121	0.966251839392011	0.741962194339482	0.778607848272377	0.751399992366137	0.717797766200919	0.590837460814513	0.732524396312827	0.801520242462045	0.731495587450387	0.779467651730728	p.Ser385Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-0.8	-3.5	2.7	143	214	-71	9.2	12.3	-3.1	105	147	-42	5.68	3.22	-2.46	-1.267	-3.136	1.869	2.008	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S385F	385	S	F	missense	low	0.336671512264804	0.308486084797194	5	0.137959171143858	0.066276505485845	0.607066519043763	NA	0.616714899484849	0.324042277288773	0.529406290373552	-0.175409732978321	NA	NA	0.388603827155167	0.489345059974718	NA	0.592518713039768	0.452979112325449	0.527869225317747	0.314607034568221	NA	NA	0.489345059974718	p.Ser385Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	-0.8	2.8	-3.6	143	228	-85	9.2	5.2	4	105	165	-60	5.68	3.32	-2.36	-1.267	-3.937	2.67	1.139	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
S385G	385	S	G	missense	possibly_low	0.686305652570183	0.0988750154772335	8	0.0349575969669383	0.617790021528917	0.754821283611448	0.758196742858823	0.582792249401804	0.729453891529324	0.822595615153342	0.653188325069218	0.558223420097525	0.60778473715549	0.778210239295937	0.637966994965368	0.667844922102384	0.576880942254725	0.651814236788847	0.656447855565235	0.624119753141889	0.566474816877558	0.614936115999594	0.685024123453768	p.Ser385Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-0.8	-9.4	8.6	143	97	46	9.2	9	0.199999999999999	105	75	30	5.68	3.29	-2.39	-1.267	-2.871	1.604	2.142	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S385H	385	S	H	missense	possibly_low	0.649603201362601	0.1699163702466	2	0.120149017635975	0.414115454018222	0.88509094870698	NA	NA	NA	NA	0.529454183726626	NA	NA	0.769752218998576	0.629338234987964	NA	NA	NA	NA	0.577900370782285	NA	NA	0.680776099193643	p.Ser385His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.8	-3.2	2.4	143	216	-73	9.2	10.4	-1.2	105	155	-50	5.68	7.59	1.91	-1.267	-4.376	3.109	0.729	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385I	385	S	I	missense	low	0.351353161130004	0.120569398097898	3	0.0696107744478524	0.214918550276272	0.487787771983736	NA	0.325926779922752	NA	NA	NA	0.245524780495026	NA	0.482607922972233	0.45847028375745	NA	0.45847028375745	NA	NA	NA	0.412354197222488	NA	0.53655843444565	p.Ser385Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-0.8	4.5	-5.3	143	191	-48	9.2	5.2	4	105	131	-26	5.68	6.02	0.34	-1.267	-3.596	2.329	2.642	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385K	385	S	K	missense	low	0.520085633022521	0.166672518584094	7	0.0629962906517579	0.396615172185458	0.643556093859583	0.440130837806284	0.664194433062566	0.469927028489418	0.493241871747419	0.223191557750276	NA	0.665860101429771	0.684053600871912	0.524528647768903	0.516516633028564	0.614405978959485	0.524528647768903	0.512009263792418	0.46349969479372	NA	0.646215123487296	0.637734134754887	p.Ser385Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-0.8	-3.9	3.1	143	230	-87	9.2	11.3	-2.1	105	146	-41	5.68	9.74	4.06	-1.267	-3.153	1.886	2.3	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S385L	385	S	L	missense	low	0.415859874557779	0.142966475539645	8	0.0505462821682117	0.316790981955685	0.514928767159873	0.575665602809643	0.478832826912277	0.539488284510035	0.563348273714204	0.337126347632679	0.205300552142794	0.263208281222724	0.363908827517875	0.51750802338754	0.581000891706314	0.528957398078285	0.558645137067315	0.542754534423398	0.506058648696795	0.392528773592012	0.42934951348938	0.476942044390122	p.Ser385Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	145	-0.8	3.8	-4.6	143	191	-48	9.2	4.9	4.3	105	131	-26	5.68	9.71	4.03	-1.267	-3.169	1.902	3.257	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385M	385	S	M	missense	low	0.558989791396041	0.0553255627085279	8	0.0195605402820808	0.520651836925018	0.597327745867064	0.546728609030374	0.530422837852004	0.593660073366524	0.55854328233313	0.555024648874463	0.668915433047492	0.475975556544111	0.54264789012023	0.566973370412882	0.567233349539752	0.552739524884368	0.58521382430106	0.540647298047743	0.587451906784855	0.621031887059898	0.5439445622003	0.566713391286012	p.Ser385Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	-0.8	1.9	-2.7	143	203	-60	9.2	5.7	3.5	105	149	-44	5.68	5.74	0.06	-1.267	-4.35	3.083	0.989	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
S385N	385	S	N	missense	possibly_wt-like	0.89160232996275	0.29481359549596	3	0.170210708720354	0.557995471087819	1.22520918883768	1.19918792310624	NA	NA	NA	0.61148303871479	0.864136028067218	NA	NA	0.717250786867453	0.877658170688282	NA	NA	NA	0.608541251076763	0.717250786867453	NA	NA	p.Ser385Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-0.8	-3.5	2.7	143	187	-44	9.2	11.6	-2.4	105	132	-27	5.68	5.47	-0.21	-1.267	-3.144	1.877	2.191	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
S385P	385	S	P	missense	low	0.635521428056866	0.101124103519609	8	0.0357527696700629	0.565447287155987	0.705595568957746	0.662651972856813	0.699401474282883	0.709809910783214	0.715298853704112	0.424654745311621	0.564897311075874	0.702550308460836	0.604906847979577	0.615889829750396	0.622386964035589	0.630635832443075	0.642179798061861	0.609392695465202	0.538753816220893	0.569764195476714	0.665976226577927	0.597982831899573	p.Ser385Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-0.8	-1.6	0.8	143	154	-11	9.2	8	1.2	105	115	-10	5.68	6.3	0.62	-1.267	-3.525	2.258	1.324	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
S385Q	385	S	Q	missense	possibly_low	0.649866495216012	0.121177151332794	8	0.0428425927161436	0.565896556488052	0.733836433943972	0.567867903481158	0.608697029284045	0.80703675872144	0.726175870530933	0.675273301930119	0.582750181496909	0.447726577232725	0.783404339050767	0.601492718886376	0.577290929464694	0.588822609814417	0.689864945038214	0.614162827958334	0.632369327421559	0.578563387745056	0.528729848587352	0.687632849963317	p.Ser385Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-0.8	-3.5	2.7	143	214	-71	9.2	10.5	-1.3	105	146	-41	5.68	6.24	0.56	-1.267	-3.595	2.328	1.352	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385R	385	S	R	missense	low	0.423349247029143	0.123331046558707	8	0.0436041096762478	0.337886762485763	0.508811731572523	0.441424448480911	0.483251341375764	0.583641365146597	0.523399859184537	0.271107548445644	0.216979514574589	0.412479531835734	0.45451036718937	0.519789297130161	0.517132102612098	0.530994258884303	0.580300124185183	0.525235095662654	0.481398129866354	0.398285015221988	0.509746022817703	0.522446491648224	p.Ser385Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-0.8	-4.5	3.7	143	265	-122	9.2	10.5	-1.3	105	174	-69	5.68	6.34	0.66	-1.267	-3.578	2.311	1.745	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385S	385	S	S	synonymous	wt-like	1.00326286355545	0.21255241689158	8	0.0751486276708132	0.855974259833044	1.15055146727785	1.08024069881424	1.14395598352274	1.10271055177487	1.21002276907047	0.527930541584338	1.06665686345043	0.976147077401708	0.918438422824787	0.819066825083555	0.821065874386624	0.835567979546317	0.834878884889134	0.826354631020861	0.577331232806384	0.817067775780487	0.813333638645035	0.755453456162951	p.Ser385=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.8	-0.8	0	143	143	0	9.2	9.2	0	105	105	0	5.68	5.68	0	NA	NA	NA	NA	NA	NA	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
S385T	385	S	T	missense	wt-like	0.879717914156831	0.22369489355865	8	0.0790880880760621	0.724708109921618	1.03472771839204	0.388320031564205	1.06150400208387	0.867111168282469	0.904824428343225	0.798928544267097	1.04469615858449	1.08250091094776	0.889858069181544	0.730213808104486	0.4918662679954	0.797559003733481	0.719328587130729	0.692509428321244	0.678559238018005	0.806243944099273	0.870615110701268	0.741099029078243	p.Ser385Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.8	-0.7	-0.1	143	163	-20	9.2	8.6	0.6	105	119	-14	5.68	5.6	-0.08	-1.267	-1.993	0.726	12.265	12.265	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
S385V	385	S	V	missense	low	0.47293498347844	0.0799806026850347	8	0.0282774132609875	0.417512271910949	0.52835769504593	0.532469507742537	0.542400169309524	0.477249169326833	0.376449588988389	0.398651941572884	0.558836659397115	0.3680583570249	0.529364474465334	0.54365082925668	0.560449203966959	0.558260873113078	0.528119809772175	0.460789828187412	0.529040785400282	0.56677706578075	0.485821071560257	0.560041821583473	p.Ser385Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	-0.8	4.2	-5	143	165	-22	9.2	5.9	3.3	105	117	-12	5.68	5.61	-0.07	-1.267	-3.269	2.002	3.568	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
S385W	385	S	W	missense	low	0.49630497935145	0.114618789859534	5	0.0512590811249362	0.395839026465958	0.596770932236941	NA	0.508520195045589	0.6529531118118	0.366760862077212	0.404856298661743	NA	0.548434429160904	NA	0.542642775162429	NA	0.542642775162429	0.614294241005857	0.456540822068186	0.531358347469036	NA	0.582970432247831	NA	p.Ser385Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-0.8	-0.9	0.1	143	264	-121	9.2	5.4	3.8	105	204	-99	5.68	5.89	0.21	-1.267	-5.133	3.866	0.28	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
S385X	385	S	X	nonsense	possibly_low	0.610051421149341	0.205414762372772	7	0.0776394824085405	0.457880831850271	0.762222010448411	NA	0.678449345848713	0.629448719958231	0.965422766655967	0.36251816411599	0.374712767359017	0.583091856991388	0.676716327116082	0.602766454145592	NA	0.620977253850004	0.602766454145592	0.719084922982854	0.51554345266531	0.476027427821698	0.601636693891829	0.634049003267596	p.Ser385Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.8	NA	NA	143	NA	NA	9.2	NA	NA	105	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
S385Y	385	S	Y	missense	possibly_low	0.598703502287122	0.43269634653221	4	0.216348173266105	0.174668874564525	1.02273813000972	NA	0.831079429445466	0.762136758455627	NA	NA	-0.0478863517593525	NA	0.849484173006749	0.679590391520063	NA	0.691337153691113	0.667843629349013	NA	NA	0.267739863197164	NA	0.72082131817232	p.Ser385Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	144	-0.8	-1.3	0.5	143	255	-112	9.2	6.2	3	105	181	-76	5.68	5.66	-0.02	-1.267	-4.033	2.766	0.923	NA	49.88	0.008285593	0	0.236816042	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D386A	386	D	A	missense	wt-like	0.937406656974139	0.0197760747752031	3	0.0114177220949777	0.915028332882496	0.959784981065782	NA	0.950347798443845	0.94722989723028	0.914642275248293	NA	NA	NA	NA	0.746317864565316	NA	0.746317864565316	0.758623015022316	0.696815060212792	NA	NA	NA	NA	p.Asp386Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.128	-3.113	1.985	4.341	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D386C	386	D	C	missense	possibly_wt-like	0.769768343633565	0.341370077230932	5	0.152665339634544	0.470549776262285	1.06898691100485	NA	0.500249767336203	0.632102345282028	0.533306870020813	1.32769281017696	NA	0.855489925351818	NA	0.604067931219762	NA	0.538830247176053	0.604067931219762	0.529579830533653	0.87607269322934	NA	0.74834849374626	NA	p.Asp386Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.128	-5.008	3.88	0.557	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D386E	386	D	E	missense	possibly_wt-like	0.959299067180427	0.399413932083466	8	0.141214149938301	0.682524419193918	1.23607371516694	1.17972633127557	1.12099724794087	1.22070542035644	1.30817724235768	0.80609033629987	0.0553227413239577	1.05948285638158	0.923890361507444	0.841601063711629	0.868398802275617	0.824984388828471	0.892749758727833	0.869400426557286	0.681234438255797	0.318608806535894	0.858217738594787	0.758191681773012	p.Asp386Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.128	-1.926	0.798	23.441	23.441	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
D386F	386	D	F	missense	low	0.461831258376771	0.0960963484001833	4	0.0480481742000916	0.367658567421685	0.556003949331857	NA	NA	NA	NA	0.477588867237934	0.326332937732739	0.552737950746918	0.490665277789495	0.549565969189575	NA	NA	NA	NA	0.558526713132248	0.452182331052851	0.58528828054021	0.540605225246903	p.Asp386Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.128	-4.162	3.034	1.238	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D386G	386	D	G	missense	possibly_wt-like	0.739945109016162	0.380595590770203	8	0.134560861561655	0.476210666626638	1.00367955140569	0.681183176422753	0.873757298218695	0.874646551749382	1.21367951124674	0.0705241183103774	1.00509544437629	0.289987743629071	0.910687028175986	0.717017633726288	0.63120367555847	0.711010932945862	0.723024334506713	0.827958300938062	0.406472631116952	0.786725833562213	0.443772755006536	0.751560333261817	p.Asp386Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.128	-3.054	1.926	2.816	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
D386H	386	D	H	missense	low	0.524443976402325	0.1488664589797	4	0.0744332294898498	0.378557527349215	0.670330425455436	NA	NA	0.419749136828754	0.52043516940833	0.736273332166253	NA	NA	0.421318267205965	0.514855375158525	NA	NA	0.499918777249162	0.523934926392099	0.655155146200752	NA	NA	0.50577582392495	p.Asp386His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.128	-4.266	3.138	1.986	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
D386I	386	D	I	missense	possibly_low	0.610393735291773	0.146728580953553	7	0.0554581907755013	0.501697678724039	0.719089791859507	NA	0.749915234142817	0.752477756527873	0.532100056925669	0.356715833261564	0.558186834593439	0.736020636777671	0.587339794813381	0.589159813580239	NA	0.653921825614204	0.66310634806985	0.529050580790829	0.513376062602812	0.566456784881745	0.684003124267172	0.589159813580239	p.Asp386Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.128	-3.881	2.753	1.771	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D386K	386	D	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.128	-3.197	2.069	6.004	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D386L	386	D	L	missense	possibly_low	0.626787199842516	0.541962140468862	4	0.270981070234431	0.095674061690912	1.15790033799412	NA	0.0228569190166401	NA	NA	1.34081939512876	0.588074989766562	NA	0.555397495458101	0.577152348057301	NA	0.31876017841183	NA	NA	0.88097596925631	0.581187840320567	NA	0.573116855794036	p.Asp386Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.128	-3.619	2.491	2.91	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D386M	386	D	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.128	-4.74	3.612	0.987	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D386N	386	D	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.128	-3.144	2.016	3.21	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D386P	386	D	P	missense	possibly_low	0.585420740622801	0.144871385251699	4	0.0724356926258494	0.443449391880922	0.727392089364679	NA	0.699041522299876	0.38207902813672	0.678658359808503	NA	NA	NA	0.581904052246103	0.589876836417186	NA	0.630469900636742	0.481443379684735	0.593323950396714	NA	NA	NA	0.586429722437659	p.Asp386Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.128	-3.525	2.397	2.065	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D386Q	386	D	Q	missense	possibly_wt-like	0.734081351383565	0.416268929286294	5	0.186161124561041	0.369212251922449	1.09895045084468	NA	0.962573160303793	0.967455962384626	1.01355793794408	0.0216898011101253	NA	NA	0.7051298951752	0.740194676537497	NA	0.751953550635304	0.768542938480609	0.740194676537497	0.388231166356638	NA	NA	0.648319662616749	p.Asp386Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.128	-3.415	2.287	5.141	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
D386R	386	D	R	missense	low	0.445740124210403	0.271487745937377	8	0.0959854130806848	0.257612171531061	0.633868076889745	0.366425925992019	0.368076894055239	0.198568172200572	0.396299235587279	1.05495155253796	0.277372797631884	0.309791169454757	0.59443524622351	0.473697849150228	0.481449566662721	0.477900777004694	0.391440028525687	0.469494921295761	0.774193516348377	0.428051215099372	0.454438749312801	0.592723490264271	p.Asp386Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.128	-3.673	2.545	3.913	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D386S	386	D	S	missense	wt-like	0.942720347766402	0.18523232065898	6	0.0756207782476828	0.794506345918054	1.09093434961475	1.15333014896347	0.624302939629182	NA	NA	1.09353911912642	0.954496889995399	0.94200133068445	0.888651658199494	0.775197310050108	0.855840118543983	0.596016671842937	NA	NA	0.788607432144991	0.761787187955225	0.794942965067887	0.740493111506606	p.Asp386Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.128	-3.031	1.903	4.292	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D386T	386	D	T	missense	low	0.481885735360024	0.277128737466724	6	0.113137333309199	0.26014063676709	0.703630833952957	0.726136814406895	0.472851040904777	NA	NA	0.254645805050898	0.0760481012134224	0.560873547493645	0.800759103090505	0.557934977297424	0.652591560948639	0.526199895399648	NA	NA	0.475249045999834	0.328823770415491	0.5896700591952	0.696349246481372	p.Asp386Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.128	-3.292	2.164	2.977	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D386V	386	D	V	missense	possibly_wt-like	0.80868644204562	0.753138895616423	3	0.434824944121319	-0.0435547880118071	1.66092767210305	NA	0.227231324588505	NA	NA	1.65945922740996	NA	NA	0.539368774138395	0.56506646165557	NA	0.412973339849348	NA	NA	1	NA	NA	0.56506646165557	p.Asp386Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.128	-3.564	2.436	2.468	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D386W	386	D	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.128	-5.358	4.23	0.385	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D386X	386	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D386Y	386	D	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp386Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.128	-4.198	3.07	1.265	NA	78.91	0.008205398	0	0.234523929	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
P387A	387	P	A	missense	wt-like	1.0827084049902	0.114435273099564	8	0.040458978807818	1.00341026367561	1.1620065463048	1.16700608924914	1.03714102448451	1.04813675548184	1.10453018530571	1.30011425304226	1.04777232263072	1.05129323451466	0.905673375212777	0.807936566732917	0.862346809805231	0.786328081078346	0.808113032118262	0.780090695824966	0.865771058908335	0.807760101347572	0.853806862367006	0.749042235802746	p.Pro387Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.395	-2.799	1.404	5.964	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
P387C	387	P	C	missense	wt-like	1.14354716113195	0.105963974455064	4	0.0529819872275322	1.03970437433663	1.24738994792727	NA	1.27033805991864	1.02067257720286	1.17696786388141	1.10621014352489	NA	NA	NA	0.803250754830549	NA	0.893827989810217	0.794643158255333	0.811858351405765	0.793340539072524	NA	NA	NA	p.Pro387Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.395	-4.75	3.355	1.493	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P387D	387	P	D	missense	wt-like	1.05627740259813	0.147195876595677	6	0.0600924649835149	0.938498335488202	1.17405646970805	NA	1.07112651019162	1.18269053902642	1.20190975535601	1.06225309611818	NA	0.791517790783663	1.02816672411287	0.806279550153808	NA	0.801994818028588	0.87410526657416	0.822796656352555	0.776920919075607	NA	0.713893524738898	0.810564282279029	p.Pro387Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.395	-3.303	1.908	3.042	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387E	387	P	E	missense	wt-like	0.896710133343501	0.181593795237722	7	0.068636003118771	0.762186039187931	1.03123422749907	0.642680264564756	0.927534890000593	0.958197669624366	0.640085685874627	1.08643967401382	0.993544360047014	NA	1.02848838927933	0.764002185999323	0.612884894188714	0.735801497704165	0.764002185999323	0.576407844794554	0.78595552084032	0.781032619556615	NA	0.810725837983878	p.Pro387Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.395	-3.274	1.879	3.287	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387F	387	P	F	missense	wt-like	1.00777963965779	0.226558106535938	8	0.0801003867321732	0.850785766514999	1.16477351280058	0.959047456548373	1.24176460429066	1.14097904484865	1.24580850003829	0.540767552336764	0.979954703532803	1.03612649886304	0.917788756803735	0.808191583742253	0.763404975472061	0.880656107644377	0.853647761547009	0.842048518490002	0.582126341915987	0.774334648994504	0.845638158753363	0.755127162666201	p.Pro387Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.395	-4.18	2.785	1.865	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P387G	387	P	G	missense	wt-like	1.06551645414677	0.105556402326802	8	0.0373198239414687	0.992370943312117	1.13866196498143	1.15840204567462	0.95552677869663	0.908446742540454	1.02809963128092	1.20553176638504	1.16539371103595	1.07604795673671	1.02668300082385	0.820130003725745	0.858253207905232	0.748705287301896	0.73960172130758	0.746571958562122	0.830440922311448	0.865732471450452	0.867139592198586	0.809819085140043	p.Pro387Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.395	-3.128	1.733	3.506	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387H	387	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro387His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.395	-4.514	3.119	1.193	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P387I	387	P	I	missense	wt-like	0.892613356131524	0.101547756775553	5	0.0454135374225501	0.803604458372764	0.981622253890284	NA	0.797865962295237	0.916762298363229	0.892467498187308	NA	0.80718578484332	NA	1.04878523696853	0.689181567294475	NA	0.676026304302862	0.743680106136542	0.687090277556785	NA	0.689181567294475	NA	0.820919890298305	p.Pro387Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.395	-3.731	2.336	4.324	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P387K	387	P	K	missense	wt-like	0.942766497881972	0.140363362881611	8	0.0496259428618676	0.845501437173868	1.04003155859007	1.0097286693541	0.967636230285577	0.883757787581233	1.12264712074387	1.09347961990152	0.692295667752558	0.937003992511127	0.83558289492579	0.770902723580013	0.787517906472355	0.754287540687671	0.727492962555357	0.788035905783308	0.788585206933776	0.63255536623143	0.792251431745707	0.713839428266819	p.Pro387Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.395	-3.291	1.896	3.764	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387L	387	P	L	missense	wt-like	0.923337045069965	0.1135122114619	8	0.0401326272360954	0.844678541082246	1.00199554905768	0.929877846788319	0.995746055592345	1.02919309784512	0.958666405657638	0.799216272069709	0.749454818897369	0.853222890636667	1.07131897307256	0.748327121955581	0.74952676008393	0.767245697078128	0.798822068584702	0.716121910454089	0.678666715236338	0.660727550813347	0.747127483827231	0.832237415472729	p.Pro387Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.395	-3.304	1.909	5.332	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P387M	387	P	M	missense	wt-like	1.02208889098074	0.123865797438362	3	0.071513951494426	0.881924121659523	1.16225366030196	NA	NA	NA	NA	1.11069659376629	0.880552112910107	1.07501796626583	NA	0.795016397949422	NA	NA	NA	NA	0.795016397949422	0.725341826762965	0.866584846136235	NA	p.Pro387Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.395	-4.487	3.092	1.619	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P387N	387	P	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro387Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.395	-3.493	2.098	3.587	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387P	387	P	P	synonymous	possibly_wt-like	0.768349200556893	0.261171710264434	6	0.106622904232979	0.559372148333192	0.977326252780595	NA	0.761085580068305	0.729623856660169	1.09206190586195	0.309470905021171	0.796744459760853	NA	0.921108495968909	0.671553245203973	NA	0.659071167093858	0.651897596605782	0.774622712658711	0.495728294741808	0.684035323314087	NA	0.756794495211543	p.Pro387=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-1.6	-1.6	0	154	154	0	8	8	0	115	115	0	6.3	6.3	0	NA	NA	NA	NA	NA	NA	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
P387Q	387	P	Q	missense	wt-like	1.03481411185313	0.177365142151186	4	0.0886825710755929	0.860999466488556	1.20862875721771	1.00347354317351	0.842042991121097	1.02213179068337	1.27160812243455	NA	NA	NA	NA	0.789950348706523	0.784541864313123	0.696391171111671	0.795358833099923	0.853362982654429	NA	NA	NA	NA	p.Pro387Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.395	-3.733	2.338	2.213	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P387R	387	P	R	missense	possibly_wt-like	0.810309606404759	0.210422447529148	8	0.0743955697808656	0.664496969024926	0.956122243784592	0.807658820625527	1.03755322140316	0.928629831427717	0.981080497707931	0.498585530972215	0.503216301637717	0.767667426557776	0.95808522090603	0.713499760608175	0.691377817277789	0.786518096920751	0.74950056694986	0.72595164506749	0.56636976129083	0.53936331043403	0.701047876148859	0.775365983464164	p.Pro387Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.395	-3.715	2.32	2.856	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
P387S	387	P	S	missense	wt-like	1.09641945247406	0.144876250817817	8	0.0512214896930808	0.996027177441133	1.19681172750699	1.00949937924438	1.01904517654294	1.08299208202744	0.952782828476863	1.43141998784307	1.08544161180046	1.08457957608824	1.1055949777691	0.825767089039231	0.787408815622141	0.777986199722422	0.825207912848034	0.713541658613652	0.914818717839946	0.826326265230429	0.871734666011956	0.849452472232111	p.Pro387Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.395	-2.16	0.765	10.969	10.969	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
P387T	387	P	T	missense	wt-like	1.12346131098216	0.0774739412059292	4	0.0387369706029646	1.04753824373016	1.19938437823415	NA	1.167264375303	1.04496530047487	1.2090884633739	NA	NA	NA	1.07252710477685	0.829394543545722	NA	0.846312755887065	0.806557584200909	0.825944889817674	NA	NA	NA	0.832844197273771	p.Pro387Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.395	-2.125	0.73	20.076	20.076	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
P387V	387	P	V	missense	wt-like	0.899033293672503	0.0940544634525922	8	0.0332532744540951	0.833858073374451	0.964208513970555	0.915975631688889	0.861925541193866	0.950701530206979	1.01740081977385	0.92144082779314	0.714676473078806	0.837928502479062	0.972217023165433	0.740385002851947	0.742912412579487	0.705556692080669	0.760325685964061	0.741879978286617	0.724322210263153	0.643586253956575	0.738890027417278	0.782463653690372	p.Pro387Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.395	-3.298	1.903	5.84	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
P387W	387	P	W	missense	wt-like	0.981082783557869	0.224491563890675	8	0.0793697535731347	0.825520925092706	1.13664464202303	0.659903353223188	1.16685536909521	1.18918992408822	1.04293648379149	0.885820810215823	0.649742934067848	1.07024639619374	1.18396699778744	0.799601447002974	0.621079235354633	0.846124210908664	0.877292905981385	0.753078683097285	0.711016786277517	0.611582285914095	0.864014910021704	0.888814667006793	p.Pro387Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.395	-5.268	3.873	0.458	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P387X	387	P	X	nonsense	possibly_low	0.584054064442534	0.248120446470103	5	0.110962836982949	0.366570900333564	0.801537228551504	NA	0.753896687102283	0.638050689555481	0.639642962606116	0.15077338756582	NA	NA	0.737906595382969	0.606985311315492	NA	0.65575720842242	0.606985311315492	0.57621368782282	0.436448768822765	NA	NA	0.664781696609846	p.Pro387Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P387Y	387	P	Y	missense	wt-like	0.965740872040841	0.161695823391596	8	0.05716810660487	0.853693442030949	1.07778830205073	1.24553709713604	1.02107309196088	1.01602009051467	0.992496124500027	0.978435721115303	0.672561851560459	0.942578229422536	0.857224770116812	0.762266496750674	0.899710019360194	0.77892103460117	0.792361334703131	0.730957985791003	0.745611958900178	0.62282910716119	0.795253678916585	0.724709018030603	p.Pro387Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.395	-4.17	2.775	1.51	NA	81.64	0.008023906	0	0.2293366	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388A	388	E	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.075	-2.895	1.82	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E388C	388	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.075	-5.129	4.054	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388D	388	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.075	-2.611	1.536	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
E388F	388	E	F	missense	low	0.498045210157828	0.179606500670141	7	0.0678848763748214	0.364993297368224	0.631097122947431	NA	0.232229117382355	0.493796920919943	0.740917363974688	0.554791992806926	0.565234229037947	0.610100390003715	0.28924645697922	0.569930253138984	NA	0.415277238216664	0.53623569528712	0.62062773262778	0.587365000942804	0.569930253138984	0.61618331132387	0.439443013858635	p.Glu388Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.075	-4.109	3.034	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E388G	388	E	G	missense	possibly_low	0.498244084947782	0.319952477352938	6	0.130620051909015	0.242233487547361	0.754254682348203	NA	0.613945902542973	0.555193567038183	0.383711868082113	-0.0452422892540345	0.555277504000951	NA	0.926577957276506	0.565685343420741	NA	0.591242252050561	0.566347831554909	0.463974711876638	0.363229498723908	0.565022855286574	NA	0.759541521525932	p.Glu388Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.075	-3.175	2.1	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
E388H	388	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.075	-4.047	2.972	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
E388I	388	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.075	-3.827	2.752	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388K	388	E	K	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.075	-2.824	1.749	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E388L	388	E	L	missense	low	0.583674855481552	0.155350331314848	7	0.0587169061072255	0.46859183422777	0.698757876735334	0.694411457326983	0.615289292534511	0.676102872633429	0.334573133455766	0.416758334875122	0.583023608629822	NA	0.765565288915232	0.591861532227999	0.637497380997581	0.591861532227999	0.625648098203286	0.442424844073313	0.535804208220443	0.57869815251157	NA	0.678673221694632	p.Glu388Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.075	-3.4	2.325	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388M	388	E	M	missense	low	0.430675474380147	0.103987155546527	3	0.0600370122470511	0.313005092636537	0.548345856123758	NA	0.328735282228877	0.426695807610259	0.536595333301306	NA	NA	NA	NA	0.50332578903898	NA	0.459764956054718	0.50332578903898	0.531021991173514	NA	NA	NA	NA	p.Glu388Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.075	-4.522	3.447	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388N	388	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.075	-3.265	2.19	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E388P	388	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.075	-3.472	2.397	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388Q	388	E	Q	missense	possibly_low	0.620350344281473	0.441812870477324	4	0.220906435238662	0.187381687260566	1.05331900130238	NA	NA	NA	0.0709521418154122	0.865548145229472	NA	1.07024791654812	0.47465317353289	0.618003678017264	NA	NA	NA	0.326813451895034	0.703444179038437	NA	0.864015728874526	0.532563176996092	p.Glu388Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.075	-3.041	1.966	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E388R	388	E	R	missense	low	0.381091037684222	0.221303985185309	8	0.0782427743140696	0.22773801797815	0.534444057390294	0.792781998177322	0.0925496183621068	0.520115080003019	0.474141503288904	0.391487106575174	0.151831577527213	0.304804751618962	0.321016665921072	0.479516153668198	0.68429977448169	0.350887339912697	0.549143501213534	0.503632767767323	0.526364448499978	0.366175376242571	0.451753097612263	0.455399539569072	p.Glu388Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.075	-3.3	2.225	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E388S	388	E	S	missense	low	0.494083285772344	0.262101068781206	8	0.0926667215457162	0.312459848977339	0.67570672256735	0.723937358057158	0.0541154591293357	0.430981470571715	0.43622988461088	0.303325420516671	0.591909511996689	0.492426667720022	0.919740513576284	0.529116362488239	0.651545111263177	0.333169839336339	0.505427702991163	0.48700656896644	0.493432723810321	0.583077771606931	0.552805021985315	0.756107428712884	p.Glu388Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.075	-2.978	1.903	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E388T	388	E	T	missense	possibly_low	0.551259973834117	0.211710286760371	7	0.0800189669660161	0.394425680500625	0.708094267167609	0.555126655653927	0.773434552817721	0.896684059936342	0.469233342841299	0.306824494023572	0.472018119155077	NA	0.385498592410881	0.523986578311215	0.571228942927527	0.664763835703574	0.73383268466073	0.501480286438536	0.494739760126774	0.523986578311215	NA	0.487785461857979	p.Glu388Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.075	-3.239	2.164	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E388V	388	E	V	missense	possibly_wt-like	0.769548310444508	0.218994592961021	2	0.154852561725926	0.466042866547927	1.07305375434109	NA	0.614695748718582	NA	NA	0.924400872170434	NA	NA	NA	0.658507908663722	NA	0.591587918517936	NA	NA	0.725427898809508	NA	NA	NA	p.Glu388Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.075	-3.346	2.271	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
E388W	388	E	W	missense	possibly_low	0.56516046204317	0.237293357898422	3	0.137001384059564	0.296642683454284	0.833678240632056	NA	NA	NA	NA	0.837205807542707	0.400824626334508	0.457450952252295	NA	0.533967332722859	NA	NA	NA	NA	0.692857243789235	0.488897249995419	0.533967332722859	NA	p.Glu388Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.075	-5.14	4.065	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E388X	388	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Ter	1	0	no	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E388Y	388	E	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu388Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.075	-3.98	2.905	NA	NA	NA	0.007797863	0	0.222875921	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
N389A	389	N	A	missense	wt-like	0.938217324626857	0.164277913563723	8	0.0580810133400429	0.824380630294783	1.05205401895893	0.624539400703122	1.12192927453397	1.12470682766562	1.0176796094962	0.937526669819428	0.890945887259569	0.963360964817199	0.825049962719746	0.736233438117347	0.604253897131521	0.825414037402293	0.845667012561948	0.742002241949028	0.7303308807491	0.730464634285667	0.806447122886294	0.708549283532183	p.Asn389Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	111	-3.5	1.8	-5.3	187	121	66	11.6	8.1	3.5	132	89	43	5.47	6	0.53	-1.224	-2.962	1.738	5.449	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N389C	389	N	C	missense	possibly_low	0.676747023500276	0.178138980410751	6	0.0727249342176648	0.534208771655608	0.819285275344943	0.761742695054533	0.785134063394579	0.838466139273046	0.708315325298061	0.3459547971432	NA	NA	0.620869120838238	0.637931030606885	0.669532002894102	0.670157113181902	0.705279562119406	0.606330058319669	0.509356408548212	NA	NA	0.605999852427591	p.Asn389Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	139	-3.5	2.5	-6	187	148	39	11.6	5.5	6.1	132	121	11	5.47	5.07	-0.4	-1.224	-4.828	3.604	0.909	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389D	389	N	D	missense	wt-like	1.10539885170412	0.0699655101735412	8	0.0247365433464437	1.05691611764308	1.15388158576516	1.05243640499912	1.17184777849762	1.04078387614675	1.23115647530872	1.11124532198902	1.081219144781	1.12650636028043	1.02799545163031	0.817361693779816	0.807837244265917	0.848425627623129	0.804506794343117	0.835622850463052	0.795221368697695	0.824245126552179	0.89431615496292	0.810478261007454	p.Asn389Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	11.6	13	-1.4	132	133	-1	5.47	5.05	-0.42	-1.224	-2.939	1.715	2.443	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
N389E	389	N	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn389Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	187	214	-27	11.6	12.3	-0.700000000000001	132	147	-15	5.47	3.22	-2.25	-1.224	-3.085	1.861	2.574	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N389F	389	N	F	missense	wt-like	0.902556964639386	0.281616735291665	8	0.0995665516101765	0.707410109418592	1.09770381986018	0.536355243627582	1.1576564550834	1.03930008197898	1.08904519734668	0.424268965207782	0.961098556972284	0.850223189313506	1.16250802758488	0.769170349903232	0.562297945859554	0.841883666362889	0.803779063839933	0.773299730489966	0.538609712758966	0.765040969316498	0.745511864513939	0.878036940918073	p.Asn389Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	-3.5	2.8	-6.3	187	228	-41	11.6	5.2	6.4	132	165	-33	5.47	3.32	-2.15	-1.224	-4.103	2.879	1.041	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389G	389	N	G	missense	possibly_wt-like	0.808769672366346	0.234213036549031	8	0.0828068131930563	0.646471300833419	0.971068043899272	0.447240543241786	0.778498809618849	0.537586035986504	0.741856034331967	0.817990274856038	1.07207430375251	1.05056395045287	1.02434742669025	0.676388944156285	0.519899263930785	0.667098372859685	0.557712174594976	0.621039387959649	0.685679515452885	0.819737884154995	0.85341407478979	0.808646047569543	p.Asn389Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-9.4	5.9	187	97	90	11.6	9	2.6	132	75	57	5.47	3.29	-2.18	-1.224	-2.779	1.555	3.342	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
N389H	389	N	H	missense	wt-like	0.956238604822291	0.220684110442556	8	0.0780236154970261	0.803315128504518	1.10916208114006	1.33914764574968	0.972716099463157	1.0537959466156	0.800431759745296	0.750792800784658	1.07233047837684	0.639502064243932	1.02119204359917	0.781845268714822	0.944247720308127	0.756629274886578	0.810888596344638	0.646727862616957	0.660578716966675	0.819864145631195	0.632018858809502	0.807061262543066	p.Asn389His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-3.2	-0.3	187	216	-29	11.6	10.4	1.2	132	155	-23	5.47	7.59	2.12	-1.224	-3.968	2.744	0.963	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
N389I	389	N	I	missense	wt-like	0.949559219671077	0.293831426078931	8	0.103885096953063	0.745948171112622	1.15317026822953	0.51123195021966	1.0741245394347	1.18033369022879	1.21353638808038	1.09473001698488	0.568558159189682	0.746729511856264	1.20722950137426	0.796214568299047	0.550344872779644	0.803376859054136	0.872949344278013	0.827895534052871	0.789052277543959	0.571568527534187	0.689770853629768	0.900498214233433	p.Asn389Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-3.5	4.5	-8	187	191	-4	11.6	5.2	6.4	132	131	1	5.47	6.02	0.55	-1.224	-3.821	2.597	1.501	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
N389K	389	N	K	missense	wt-like	0.911053242555283	0.17765804276684	3	0.102570918815137	0.710017935816432	1.11208854929413	NA	NA	NA	NA	0.739913139768035	1.09458083104137	0.898665756856441	NA	0.771602711327103	NA	NA	NA	NA	0.656514752025278	0.830830736802047	0.771602711327103	NA	p.Asn389Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-3.9	0.4	187	230	-43	11.6	11.3	0.299999999999999	132	146	-14	5.47	9.74	4.27	-1.224	-3.102	1.878	2.703	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
N389L	389	N	L	missense	wt-like	1.13678739763556	0.0755290772697085	8	0.0267035613570868	1.08444937911671	1.1891254161544	1.15353692002166	1.12019050354449	1.07214782533877	1.1833761640007	1.28676767343303	1.10700351496037	1.13261740493043	1.03865917485501	0.830783015840454	0.855938495358252	0.824612493238893	0.819889320452884	0.81466872129959	0.860785606554938	0.836953538442015	0.897607523235058	0.815834095277077	p.Asn389Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	-3.5	3.8	-7.3	187	191	-4	11.6	4.9	6.7	132	131	1	5.47	9.71	4.24	-1.224	-3.394	2.17	2.116	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389M	389	N	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn389Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	-3.5	1.9	-5.4	187	203	-16	11.6	5.7	5.9	132	149	-17	5.47	5.74	0.27	-1.224	-4.515	3.291	0.746	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389P	389	N	P	missense	wt-like	0.990348004026452	0.250075749504882	8	0.0884151291426051	0.817057535218488	1.16363847283442	0.947609003321417	0.920542883543699	1.08442562108425	1.142177619559	1.27968409963433	0.437493783773387	1.08120949223282	1.02964152906271	0.803953018169354	0.757962828014602	0.732578300399922	0.825910995608301	0.796601036139219	0.858139623786381	0.506970476261749	0.869919561113949	0.81130500019949	p.Asn389Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	-1.6	-1.9	187	154	33	11.6	8	3.6	132	115	17	5.47	6.3	0.83	-1.224	-3.69	2.466	1.452	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389Q	389	N	Q	missense	wt-like	1.02570292147953	0.175769412045066	5	0.0786064707395876	0.871637069878139	1.17976877308092	NA	1.16692418764274	0.99909871340909	1.12397368970524	0.731362018251395	NA	NA	1.1071559983892	0.788617674645834	NA	0.84615593510089	0.784062203635604	0.788617674645834	0.653320584670233	NA	NA	0.85023649180544	p.Asn389Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	187	214	-27	11.6	10.5	1.1	132	146	-14	5.47	6.24	0.77	-1.224	-3.545	2.321	1.65	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
N389R	389	N	R	missense	wt-like	0.905045405133386	0.185752447143941	6	0.0758331189959931	0.756415223065899	1.05367558720087	NA	1.00878935642916	0.910597754798576	1.08677899251568	0.551004459000819	0.962713283496357	NA	0.910388584559723	0.75862363222872	NA	0.773258439250901	0.740656690566088	0.77230588286864	0.585950213792832	0.765836823922005	NA	0.751410440535435	p.Asn389Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.5	-4.5	1	187	265	-78	11.6	10.5	1.1	132	174	-42	5.47	6.34	0.87	-1.224	-3.404	2.18	1.975	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
N389S	389	N	S	missense	wt-like	1.1890178205471	0.339855374051523	2	0.240314039614523	0.718010957923303	1.66002468317089	NA	NA	NA	NA	1.42933186016162	NA	0.948703780932576	NA	0.856295791824857	NA	NA	NA	NA	0.914038723162024	NA	0.79855286048769	NA	p.Asn389Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-0.8	-2.7	187	143	44	11.6	9.2	2.4	132	105	27	5.47	5.68	0.21	-1.224	-2.026	0.802	10.969	10.969	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
N389T	389	N	T	missense	wt-like	0.971294409093339	0.179609014873138	8	0.0635013761895157	0.846833998793159	1.09575481939352	1.07730322816904	0.870166494708078	0.755854696981889	0.814072899775758	0.832546680156753	1.24481017163283	1.01031176585744	1.16528933546493	0.764511963893951	0.819668294828795	0.709355632959108	0.66476257683068	0.65271020560113	0.691116883466878	0.904874676013808	0.831734514117373	0.879433847396654	p.Asn389Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	187	163	24	11.6	8.6	3	132	119	13	5.47	5.6	0.13	-1.224	-3.007	1.783	4.097	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
N389V	389	N	V	missense	wt-like	0.895514990935536	0.120435900326796	8	0.0425805209096923	0.812058703509584	0.978971278361487	0.75915203497741	0.845739711040847	0.82061861193936	1.08883543678613	0.757020821716008	1.01460502997775	0.951744473260164	0.926403807786621	0.728774676031763	0.66829942766106	0.69809529678051	0.696526198392012	0.773207739672853	0.662905118375747	0.79141284859823	0.800190557285134	0.759454055283016	p.Asn389Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	-3.5	4.2	-7.7	187	165	22	11.6	5.9	5.7	132	117	15	5.47	5.61	0.14	-1.224	-3.564	2.34	2.056	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
N389W	389	N	W	missense	possibly_wt-like	1.0633207861553	0.485120640379702	6	0.198049672103748	0.675150561681991	1.45149101062862	NA	1.28677516000659	1.26128196856822	1.55030170919531	0.142602143954167	1.03314637307263	NA	1.1058173621349	0.875484690334679	NA	0.90140521632162	0.912650626711346	0.975584484652744	0.43339650023511	0.800551370245315	NA	0.849564164347737	p.Asn389Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.5	-0.9	-2.6	187	264	-77	11.6	5.4	6.2	132	204	-72	5.47	5.89	0.42	-1.224	-5.358	4.134	0.25	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
N389X	389	N	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asn389Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	11.6	NA	NA	132	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
N389Y	389	N	Y	missense	wt-like	1.0234186838893	0.298917827227811	8	0.105683411325167	0.816283003928639	1.23055436384996	1.23685568792437	1.09158164326243	1.02660227745757	1.11370900951963	1.2708509928092	0.343886067780762	1.19768120106145	0.906182591298992	0.804487842234763	0.895579608706669	0.811424290123362	0.797551394346164	0.784116083330442	0.854840124251782	0.46083378947725	0.932650453947445	0.749297988592623	p.Asn389Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	143	-3.5	-1.3	-2.2	187	255	-68	11.6	6.2	5.4	132	181	-49	5.47	5.66	0.19	-1.224	-4.033	2.809	0.898	NA	49.88	0.007624486	0	0.217920496	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	N	D	D	D	D	D	0.785714285714286
E390A	390	E	A	missense	possibly_wt-like	0.788603897080442	0.17629379269762	7	0.0666327904517538	0.658006027605601	0.919201766555284	NA	0.879723490450197	0.680072486940904	0.52367001166893	0.831993522738202	0.912653063043704	0.655883033770862	1.0362316709503	0.69091025824642	NA	0.713761247156201	0.627595005314907	0.525353571451045	0.69091025824642	0.741163508406338	0.640841540765809	0.814614886157659	p.Glu390Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.316	-3.031	1.715	4.155	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E390C	390	E	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.316	-5.131	3.815	0.622	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E390D	390	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.316	-2.027	0.711	32.387	32.387	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
E390E	390	E	E	synonymous	wt-like	1.00350986960382	0.253908142470862	5	0.11355117332111	0.780953659492177	1.22606607971546	NA	1.18485084981286	1.20493471297424	1.10662174336373	NA	0.593612592387008	NA	0.927529449481243	0.781007951834834	NA	0.854419824663499	0.885014976459474	0.781007951834834	NA	0.583917173420166	NA	0.760019406636979	p.Glu390=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E390F	390	E	F	missense	possibly_wt-like	0.755218636119474	0.372000344509113	6	0.151868504697814	0.457561836525807	1.05287543571314	NA	0.960254674724629	0.974955760961649	1.05506973603858	0.254073516932636	0.300281945842047	NA	0.986676182217302	0.754642253686247	NA	0.750884767802399	0.772221233159724	0.758399739570096	0.475035274739365	0.439342508602947	NA	0.78972573822953	p.Glu390Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.316	-4.205	2.889	1.178	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E390G	390	E	G	missense	wt-like	0.863938104816591	0.165897059031605	8	0.0586534677100763	0.748979420536458	0.978896789096723	0.789209890696991	0.749383313387245	0.940949004763279	0.964093295081058	1.06301556255834	0.536776787142374	0.906748369343943	0.961328615559494	0.737022208510451	0.682600249619706	0.653676619097877	0.755542535846215	0.718501881174687	0.777205729133299	0.555904357201864	0.775955953010147	0.776994972126839	p.Glu390Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.316	-3.223	1.907	3.84	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E390H	390	E	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.316	-4.225	2.909	1.474	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E390I	390	E	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.316	-3.923	2.607	1.944	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E390K	390	E	K	missense	wt-like	0.970096588954716	0.0132058131488093	2	0.00933792002860551	0.951794602008134	0.988398575901298	NA	NA	NA	NA	0.960758668926111	NA	0.979434508983322	NA	0.777056569400578	NA	NA	NA	NA	0.739008911226692	NA	0.815104227574465	NA	p.Glu390Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.316	-2.139	0.823	20.007	20.007	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E390L	390	E	L	missense	wt-like	0.922675274006728	0.174387114600752	7	0.0659121338696729	0.793489865477987	1.05186068253547	1.07985224418659	0.761199408910449	0.654522924882526	NA	1.13111451506123	0.884041989023795	1.04318238748131	0.904813448501199	0.748610339282723	0.820881056796143	0.659123640274398	0.6150641596918	NA	0.802643263914461	0.727061891390828	0.849438413744122	0.748610339282723	p.Glu390Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.316	-3.486	2.17	3.059	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E390M	390	E	M	missense	possibly_low	0.606671047142455	0.0957648290313758	2	0.0677159600072562	0.473950204349678	0.739391889935232	NA	0.538955087135199	NA	NA	NA	NA	NA	0.674387007149711	0.594775927525181	NA	0.556672748209928	NA	NA	NA	NA	NA	0.632879106840435	p.Glu390Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.316	-4.608	3.292	1.128	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E390N	390	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.316	-3.313	1.997	5.663	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E390P	390	E	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.316	-3.568	2.252	1.958	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E390Q	390	E	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.316	-3.254	1.938	3.845	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
E390R	390	E	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.316	-3.356	2.04	7.74	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E390S	390	E	S	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.316	-3.074	1.758	4.268	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E390T	390	E	T	missense	possibly_wt-like	0.743525118388588	0.199050033221753	4	0.0995250166108764	0.548459670270519	0.938590566506656	0.471826839806229	0.718335148531441	0.904948880122221	NA	NA	NA	NA	0.878989605094459	0.687502150867288	0.531596846521865	0.639363937626273	0.737886186071649	NA	NA	NA	NA	0.735640364108304	p.Glu390Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.316	-3.334	2.018	2.914	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E390V	390	E	V	missense	wt-like	0.979094101346364	0.132530985835105	4	0.0662654929175525	0.849216121810167	1.10897208088256	NA	0.820633201299532	0.980021803455163	NA	NA	0.970756409611282	NA	1.14496499101948	0.772253473650553	NA	0.68652161832125	0.774705886174961	NA	NA	0.769801061126145	NA	0.869225984889826	p.Glu390Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.316	-3.482	2.166	2.404	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.695	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
E390W	390	E	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.316	-5.276	3.96	0.338	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E390X	390	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu390Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E390Y	390	E	Y	missense	possibly_low	0.668550718979269	0.464923431887542	7	0.175724539923016	0.324136949530287	1.01296448842825	0.812983201667264	0.00595452962926937	0.315886392110865	0.271117512263971	1.18272910676998	NA	1.10037883616381	0.990805454249725	0.693911032754909	0.693911032754909	0.310968461364012	0.448979038357424	0.414596283601432	0.821923266374868	NA	0.880244043101182	0.791799657084497	p.Glu390Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.316	-4.116	2.8	1.241	NA	81.64	0.00727039	0	0.207799851	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.695	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
P391A	391	P	A	missense	wt-like	1.03565642002738	0.101112603619145	6	0.041279047571866	0.954750973470406	1.11656186658435	NA	0.95004051382037	1.12686821973983	0.933827049242359	1.01970035221549	NA	1.18806332416196	0.995439060984268	0.777576368311284	NA	0.746176211525359	0.846727072626813	0.705228572415589	0.761025859558903	NA	0.927470328995769	0.794126877063664	p.Pro391Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	27	-1.6	1.8	-3.4	154	121	33	8	8.1	-0.0999999999999996	115	89	26	6.3	6	-0.3	-1.538	-2.961	1.423	6.559	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
P391C	391	P	C	missense	wt-like	1.09895443484021	0.120495508323572	5	0.0538872295189796	0.993337405756367	1.20457146392405	NA	0.889664298187196	1.10256121942171	NA	1.17032275614255	1.17470261022832	1.15752129022128	NA	0.83480564446882	NA	0.718343792223547	0.83480564446882	NA	0.817289025112801	0.870320573636181	0.911020591309954	NA	p.Pro391Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	169	-1.6	2.5	-4.1	154	148	6	8	5.5	2.5	115	121	-6	6.3	5.07	-1.23	-1.538	-4.917	3.379	1.291	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P391D	391	P	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-1.6	-3.5	1.9	154	187	-33	8	13	-5	115	133	-18	6.3	5.05	-1.25	-1.538	-3.441	1.903	4.238	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P391E	391	P	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-1.6	-3.5	1.9	154	214	-60	8	12.3	-4.3	115	147	-32	6.3	3.22	-3.08	-1.538	-3.298	1.76	9.098	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
P391F	391	P	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	-1.6	2.8	-4.4	154	228	-74	8	5.2	2.8	115	165	-50	6.3	3.32	-2.98	-1.538	-4.14	2.602	4.456	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P391G	391	P	G	missense	wt-like	0.848147518844107	0.199995035367397	8	0.0707089228559648	0.709560576660795	0.986734461027419	0.623891922195811	1.0144571448059	0.830654045963127	1.04817567854667	0.756068350882934	0.529179834178597	0.91901893509733	1.06373423908249	0.72841222087571	0.603945842061276	0.775871194306197	0.701448101719567	0.755376340031854	0.662549334489888	0.552160026558929	0.782564798651922	0.828427997563615	p.Pro391Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-1.6	-9.4	7.8	154	97	57	8	9	-1	115	75	40	6.3	3.29	-3.01	-1.538	-2.123	0.585	42.636	42.636	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P391H	391	P	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-1.6	-3.2	1.6	154	216	-62	8	10.4	-2.4	115	155	-40	6.3	7.59	1.29	-1.538	-4.543	3.005	2.697	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
P391I	391	P	I	missense	possibly_wt-like	0.82301218685805	0.296654276194045	8	0.104883125182398	0.617445038914544	1.02857933480156	0.57857725113569	0.881593961217132	0.964001096110078	1.17171174645828	0.389756852101478	1.09001327474533	0.486908395135005	1.0215349179614	0.740735996754889	0.582386185611025	0.71462350270056	0.766848490809219	0.809553273009089	0.525718133002643	0.828579513043765	0.549832916830868	0.807233470525281	p.Pro391Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-1.6	4.5	-6.1	154	191	-37	8	5.2	2.8	115	131	-16	6.3	6.02	-0.28	-1.538	-3.644	2.106	9.366	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
P391K	391	P	K	missense	wt-like	1.15614660665467	0.256882783482167	6	0.104871957206193	0.950601347542307	1.36169186576704	1.03804259819124	1.14781991035178	1.07747899787515	0.929748256376493	1.65945922740996	NA	NA	1.08433064972341	0.829926595968402	0.800989008969724	0.837349184786321	0.822504007150484	0.703439811518001	1	NA	NA	0.838772504788485	p.Pro391Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-3.9	2.3	154	230	-76	8	11.3	-3.3	115	146	-31	6.3	9.74	3.44	-1.538	-3.355	1.817	7.963	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P391L	391	P	L	missense	possibly_low	0.705635881042502	0.313282102020536	7	0.118409504593415	0.473557516612179	0.937714245472826	NA	0.247929295675257	0.821535399907671	0.6330025728264	1.00545838563646	0.622101415115067	1.15411634430106	0.455307753835603	0.597958536112608	NA	0.422514756182616	0.696975839308509	0.573301534650714	0.755705946301928	0.597958536112608	0.90918670993418	0.522846977541945	p.Pro391Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-1.6	3.8	-5.4	154	191	-37	8	4.9	3.1	115	131	-16	6.3	9.71	3.41	-1.538	-2.289	0.751	30.563	30.563	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
P391M	391	P	M	missense	wt-like	1.15032967798253	0.092234407868381	8	0.032609787631229	1.08641566868182	1.21424368728324	1.06265258100606	1.0646900825476	1.02763017704959	1.18883383135528	1.30605023870782	1.19382845893517	1.18816782363657	1.17078423062216	0.842525281913986	0.812697860922553	0.799027733206931	0.7980555302321	0.817062189729337	0.867988374098636	0.879747182136544	0.927526611722353	0.882193647812603	p.Pro391Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-1.6	1.9	-3.5	154	203	-49	8	5.7	2.3	115	149	-34	6.3	5.74	-0.56	-1.538	-4.346	2.808	4.056	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
P391N	391	P	N	missense	wt-like	0.916313258313037	0.0873171768566406	3	0.0504125955630596	0.817506386642256	1.01512012998382	NA	0.937921464155703	0.990797510132604	0.820220800650804	NA	NA	NA	NA	0.740589533588208	NA	0.740589533588208	0.77999085804831	0.655406377005067	NA	NA	NA	NA	p.Pro391Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-1.6	-3.5	1.9	154	187	-33	8	11.6	-3.6	115	132	-17	6.3	5.47	-0.83	-1.538	-3.669	2.131	3.935	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P391Q	391	P	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-1.6	-3.5	1.9	154	214	-60	8	10.5	-2.5	115	146	-31	6.3	6.24	-0.06	-1.538	-2.502	0.964	18.845	18.845	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	-0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P391R	391	P	R	missense	wt-like	0.983274108139964	0.268434318603872	5	0.120047476778419	0.747985377219355	1.21856283906057	1.27018697512516	1.13992779459634	0.822993733737389	0.601263347271577	NA	NA	NA	1.08199868996935	0.833711052243891	0.911437852500174	0.833711052243891	0.6976910827262	0.559382248366944	NA	NA	NA	0.837601282533087	p.Pro391Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-1.6	-4.5	2.9	154	265	-111	8	10.5	-2.5	115	174	-59	6.3	6.34	0.04	-1.538	-3.699	2.161	6.392	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
P391S	391	P	S	missense	possibly_wt-like	0.829098431523403	0.403118267322751	8	0.142523830222044	0.549756857349495	1.10844000569731	0.543770929925587	0.989228583533223	0.952869878775692	0.504477622579423	1.19088149803586	1.21785852729769	1.13533784082884	0.0983625712109132	0.76281520500192	0.565826155271373	0.764241252145054	0.761389157858786	0.516936719636406	0.824968492898239	0.891590946570869	0.899072732035713	0.343571953125455	p.Pro391Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	74	-1.6	-0.8	-0.8	154	143	11	8	9.2	-1.2	115	105	10	6.3	5.68	-0.62	-1.538	-3.26	1.722	4.868	NA	88.09	0.009538792	0	0.27263456	8.335e-06	2	239944	not specified|Hereditary cancer-predisposing syndrome	Uncertain significance(Last reviewed: Apr 15, 2016)	criteria provided, multiple submitters, no conflicts	0	0	1	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
P391T	391	P	T	missense	possibly_wt-like	0.894481483178726	0.38449555403456	4	0.19224777701728	0.51768276411697	1.27128020224048	0.357929074940675	1.25770005366885	1.04699658664376	0.915300217461621	NA	NA	NA	NA	0.75232871764431	0.477406964448244	0.888002081621135	0.807553833504147	0.697103601784472	NA	NA	NA	NA	p.Pro391Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-1.6	-0.7	-0.9	154	163	-9	8	8.6	-0.6	115	119	-4	6.3	5.6	-0.7	-1.538	-3.387	1.849	3.547	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
P391V	391	P	V	missense	wt-like	0.897471995028091	0.19703148471511	8	0.069661149474654	0.760938650936108	1.03400533912007	1.1184081223718	0.977593728011125	0.780799346738325	0.780993347610621	0.855124553928594	0.597001138349263	1.20737136418605	0.86248435902895	0.713450604865032	0.839225038300679	0.758877779558853	0.676996741725802	0.638203117016687	0.699550573387902	0.585587295183715	0.937869511782364	0.727350636342162	p.Pro391Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-1.6	4.2	-5.8	154	165	-11	8	5.9	2.1	115	117	-2	6.3	5.61	-0.69	-1.538	-3.327	1.789	7.8	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
P391W	391	P	W	missense	wt-like	1.08345336118005	0.0693913143136505	4	0.0346956571568252	1.01545112273272	1.15145559962737	NA	1.05893609073887	1.11649428051208	1.15892966535302	NA	NA	NA	0.999453408116224	0.800161455730401	NA	0.796375239820252	0.841639148588452	0.803947671640549	NA	NA	NA	0.796143075110674	p.Pro391Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	147	-1.6	-0.9	-0.7	154	264	-110	8	5.4	2.6	115	204	-89	6.3	5.89	-0.41	-1.538	-5.205	3.667	0.602	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
P391X	391	P	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-1.6	NA	NA	154	NA	NA	8	NA	NA	115	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
P391Y	391	P	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Pro391Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-1.6	-1.3	-0.3	154	255	-101	8	6.2	1.8	115	181	-66	6.3	5.66	-0.64	-1.538	-4.128	2.59	1.818	NA	88.09	0.009538792	0	0.27263456	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
F392A	392	F	A	missense	wt-like	1.06605586278558	0.261087247211382	5	0.116761766564589	0.837207005547715	1.29490472002345	1.14807214701356	1.12525964793565	1.14857168084623	1.29374403348387	NA	NA	NA	0.614631804648603	0.853338484680097	0.853338484680097	0.82694928349175	0.857371588567636	0.863070720561121	NA	NA	NA	0.602867172490666	p.Phe392Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	2.8	1.8	1	228	121	107	5.2	8.1	-2.9	165	89	76	3.32	6	2.68	-1.731	-3.112	1.381	5.243	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
F392C	392	F	C	missense	wt-like	1.2174902241868	0.281396906845235	6	0.114879806161386	0.992329941559542	1.44265050681406	NA	1.41414488283426	1.10970316061848	0.92810482800779	1.65945922740996	1.23351282463939	NA	0.960016421610923	0.868807474663052	NA	0.960120514968912	0.838308427114629	0.702719083474044	1	0.899306522211475	NA	0.776335925265808	p.Phe392Cys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	205	2.8	2.5	0.3	228	148	80	5.2	5.5	-0.3	165	121	44	3.32	5.07	1.75	-1.731	-2.681	0.95	39.335	39.335	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
F392D	392	F	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	2.8	-3.5	6.3	228	187	41	5.2	13	-7.8	165	133	32	3.32	5.05	1.73	-1.731	-3.912	2.181	1.596	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392E	392	F	E	missense	wt-like	1.19124490105172	0.255120033931253	3	0.147293620265876	0.902554710178083	1.47993509192535	1.45632930033303	NA	NA	NA	1.16998579831412	NA	NA	0.94741960450801	0.817163158617568	1	NA	NA	NA	0.817163158617568	NA	NA	0.770009198351918	p.Phe392Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	2.8	-3.5	6.3	228	214	14	5.2	12.3	-7.1	165	147	18	3.32	3.22	-0.1	-1.731	-3.844	2.113	2.322	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392G	392	F	G	missense	wt-like	0.966201636620391	0.167464586463725	8	0.0592076723485504	0.850156731208784	1.082246542032	0.613647474115689	1.17575695650863	0.969465568611613	1.09027003534079	0.997861740769982	0.881306315272194	1.03317881138419	0.968126190960036	0.771682719941485	0.599071774216077	0.850227692896462	0.769528554802958	0.773836885080011	0.7528683120813	0.72571355250996	0.844050553752958	0.780409041163839	p.Phe392Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	153	2.8	-9.4	12.2	228	97	131	5.2	9	-3.8	165	75	90	3.32	3.29	-0.03	-1.731	-3.609	1.878	2.537	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392H	392	F	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	100	2.8	-3.2	6	228	216	12	5.2	10.4	-5.2	165	155	10	3.32	7.59	4.27	-1.731	-4.436	2.705	4.058	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F392I	392	F	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	2.8	4.5	-1.7	228	191	37	5.2	5.2	0	165	131	34	3.32	6.02	2.7	-1.731	-2.379	0.648	10.137	3.773	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
F392K	392	F	K	missense	wt-like	1.28770927327595	0.132111715500768	4	0.0660558577503841	1.15824217111729	1.4171763754346	NA	NA	NA	NA	1.34706719685836	1.41707064924351	1.27789340039232	1.1088058466096	0.929580987038937	NA	NA	NA	NA	0.88330975954179	0.98977716099163	0.975852214536084	0.851065124868423	p.Phe392Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	2.8	-3.9	6.7	228	230	-2	5.2	11.3	-6.1	165	146	19	3.32	9.74	6.42	-1.731	-3.794	2.063	2.665	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392L	392	F	L	missense	possibly_wt-like	0.888851114236387	0.256039619480435	2	0.181047351187039	0.534004826413416	1.24369740205936	NA	NA	1.06989846542343	NA	NA	NA	NA	0.707803763049348	0.734224361952425	NA	NA	0.818786116343727	NA	NA	NA	NA	0.649662607561122	p.Phe392Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	2.8	3.8	-1	228	191	37	5.2	4.9	0.3	165	131	34	3.32	9.71	6.39	-1.731	-2.144	0.413	33.079	33.079	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000490022050992295	0.000470858514777713	0.000470858514777713	0.000418323026650762	0.000505501194117617	0.000514048009447939	0.000249668318541937	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
F392M	392	F	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	28	2.8	1.9	0.9	228	203	25	5.2	5.7	-0.5	165	149	16	3.32	5.74	2.42	-1.731	-4.154	2.423	4.39	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F392N	392	F	N	missense	wt-like	0.94570603676512	0.211747421694472	8	0.0748640188894645	0.798975256003843	1.0924368175264	0.907815156953416	0.951162053974641	0.961337996427524	0.487815990599401	0.932217716829963	1.1950179024819	1.14135759233275	0.988923884521362	0.756117794836959	0.739029850317601	0.746693222661451	0.765542367012467	0.509629735252551	0.728347785982475	0.880333426377006	0.902314930422549	0.790854642344381	p.Phe392Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	158	2.8	-3.5	6.3	228	187	41	5.2	11.6	-6.4	165	132	33	3.32	5.47	2.15	-1.731	-4.047	2.316	1.868	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392P	392	F	P	missense	wt-like	1.13475459925383	0.0718437604883031	3	0.0414790144575168	1.05345722480288	1.21605197370478	1.13657165497425	NA	NA	NA	1.20567259610756	NA	1.06201954667968	NA	0.847866820612462	0.847866820612462	NA	NA	NA	0.830493527540063	NA	0.859583983229144	NA	p.Phe392Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	114	2.8	-1.6	4.4	228	154	74	5.2	8	-2.8	165	115	50	3.32	6.3	2.98	-1.731	-4.147	2.416	1.26	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392Q	392	F	Q	missense	possibly_wt-like	0.847153501279502	0.553661941222138	2	0.391498113123081	0.0798312995428742	1.61447570301613	NA	NA	NA	1.23865161440258	NA	NA	NA	0.45565538815642	0.680965715734167	NA	NA	NA	0.838909855264225	NA	NA	NA	0.52302157620411	p.Phe392Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	116	2.8	-3.5	6.3	228	214	14	5.2	10.5	-5.3	165	146	19	3.32	6.24	2.92	-1.731	-4.192	2.461	1.803	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
F392R	392	F	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	2.8	-4.5	7.3	228	265	-37	5.2	10.5	-5.3	165	174	-9	3.32	6.34	3.02	-1.731	-4.045	2.314	2.471	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
F392S	392	F	S	missense	possibly_wt-like	0.949972282794681	0.269063886900823	3	0.155344107531397	0.645503426822625	1.25444113876674	1.07398334391674	NA	NA	NA	0.641265885243455	NA	NA	1.13466761922385	0.818088771856219	0.818088771856219	NA	NA	NA	0.619666270869437	NA	NA	0.86405414991362	p.Phe392Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	155	2.8	-0.8	3.6	228	143	85	5.2	9.2	-4	165	105	60	3.32	5.68	2.36	-1.731	-3.534	1.803	3.439	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
F392T	392	F	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	2.8	-0.7	3.5	228	163	65	5.2	8.6	-3.4	165	119	46	3.32	5.6	2.28	-1.731	-3.498	1.767	3.067	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
F392V	392	F	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	2.8	4.2	-1.4	228	165	63	5.2	5.9	-0.7	165	117	48	3.32	5.61	2.29	-1.731	-2.994	1.263	8.442	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
F392W	392	F	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	2.8	-0.9	3.7	228	264	-36	5.2	5.4	-0.2	165	204	-39	3.32	5.89	2.57	-1.731	-4.612	2.881	2.367	NA	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
F392X	392	F	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	2.8	NA	NA	228	NA	NA	5.2	NA	NA	165	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
F392Y	392	F	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Phe392Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	22	2.8	-1.3	4.1	228	255	-27	5.2	6.2	-1	165	181	-16	3.32	5.66	2.34	-1.731	-2.374	0.643	27.329	27.329	13.9	0.008897504	0	0.254305468	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
D393A	393	D	A	missense	wt-like	1.07854553470493	0.201974192008994	8	0.0714086603971166	0.938587132142332	1.21850393726753	0.646736350907734	1.11108051320614	1.17613667661319	0.936690177103996	1.14026567646658	1.30358295493415	1.18565020187899	1.12822172652867	0.840614826921044	0.61481468482917	0.82041294101003	0.87089090861579	0.706484201551981	0.806061568866022	0.93384217581735	0.926170637277932	0.860816712832057	p.Asp393Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.28	-3.078	1.798	4.792	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D393C	393	D	C	missense	possibly_wt-like	0.81843972190168	0.187971787488721	7	0.0710466575987768	0.679190831786129	0.957688612017232	1.08421803428811	0.530171384217646	0.99975844802791	0.870163621969409	0.73672331847632	0.8162101098165	NA	0.691833136515871	0.677308878266545	0.822958197212715	0.552623608990782	0.784385772103891	0.677308878266545	0.655323233109473	0.693629410619292	NA	0.64164139141616	p.Asp393Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.28	-5.031	3.751	0.615	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D393E	393	D	E	missense	wt-like	1.0453284177304	0.130110980964043	5	0.0581873996109562	0.931283210138883	1.15937362532191	NA	0.878804154394758	1.18243816706196	1.05232508164802	NA	1.15872790623531	NA	0.954346779311932	0.773488358437449	NA	0.713337448706664	0.87398149012277	0.757196067157037	NA	0.862447078307455	NA	0.773488358437449	p.Asp393Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.28	-1.689	0.409	25.873	25.873	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	T	D	D	B	0.428571428571429
D393F	393	D	F	missense	possibly_wt-like	0.843730475753754	0.392257758069707	7	0.148259496812598	0.553147201635031	1.13431374987248	1.20108920137533	1.02132152923102	0.983189731833285	1.02184533232167	0.420646414263712	0.159132992362597	NA	1.09888812888866	0.776259604448511	0.878562754244531	0.779035560001614	0.776259604448511	0.743829126114378	0.537256552948873	0.369774044213172	NA	0.846083970413551	p.Asp393Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.28	-4.158	2.878	1.366	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D393G	393	D	G	missense	wt-like	0.86352625356319	0.139142933152951	8	0.049194455793319	0.767106891969237	0.959945615157143	0.820198886382261	0.981526270720912	0.681614645943857	0.782336746503187	0.97474278985691	0.681443685197725	0.971954885017969	1.0143921188827	0.720788297745082	0.697344086109798	0.760690615565106	0.628351360995217	0.638792266671477	0.744232509380366	0.627206720397976	0.811075751525437	0.803646013566706	p.Asp393Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.28	-3.077	1.797	3.108	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
D393H	393	D	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp393His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.28	-4.23	2.95	2.192	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
D393I	393	D	I	missense	wt-like	1.08374390368471	0.0988368623597775	7	0.0373568225956988	1.01052587682029	1.15696193054914	NA	1.1059701890925	1.13985437399487	1.23525402582558	1.10584038358138	1.02052320513436	0.919663816862833	1.05910133130148	0.818057167598142	NA	0.818057167598142	0.853096163957461	0.837419837557394	0.793202419746483	0.794329755507462	0.782912127710016	0.826101128632503	p.Asp393Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.28	-3.876	2.596	1.955	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.75
D393K	393	D	K	missense	wt-like	1.09327136242983	0.175249726150196	6	0.0715454011050777	0.95304495300441	1.23349777185526	NA	1.05452574219303	1.1823773110484	1.33833375634309	1.07363294241472	0.804297272811698	NA	1.10646114976807	0.822114824400218	NA	0.794342143364841	0.873951643141072	0.882625612243004	0.781171722139871	0.6877578985994	NA	0.849887505435594	p.Asp393Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.28	-3.129	1.849	6.627	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D393L	393	D	L	missense	wt-like	0.933770052336557	0.190394381491924	8	0.0673145791263789	0.801835901614383	1.06570420305873	0.579406282060852	0.934642543673316	0.803725701168637	0.985975643943035	0.834518536125802	1.15270029040796	1.05647351763381	1.12271790367905	0.73358821271097	0.582780619058625	0.739078006428613	0.688241028708509	0.728098418993327	0.691853446261937	0.859476231080443	0.856596928628273	0.85805242849995	p.Asp393Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.28	-3.583	2.303	3.212	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D393M	393	D	M	missense	possibly_wt-like	0.912264331581775	0.270048987493109	6	0.110247037485559	0.696184108707843	1.12834455445571	NA	1.00049637356762	1.10615871829761	1.05885912562934	0.826630384855221	NA	0.400445286114047	1.08099610102682	0.764748547967163	NA	0.769435513718972	0.836570046650751	0.760061582215354	0.688906923372382	NA	0.50326445758361	0.837097734184767	p.Asp393Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.28	-4.705	3.425	1.089	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D393N	393	D	N	missense	possibly_wt-like	0.923176791742284	0.355749459861244	8	0.125776427735668	0.676659523276269	1.1696940602083	0.521628942176091	1.43635996648312	0.974746391417107	1.06661212190191	1.14479567681341	0.305298387148883	1.00778921344275	0.928183634554995	0.767790109015364	0.555291517419286	0.970361294660976	0.772118547351066	0.763461670679661	0.807753695354698	0.441814975523992	0.830375884053609	0.760347969819167	p.Asp393Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.28	-3.167	1.887	3.544	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D393P	393	D	P	missense	possibly_wt-like	0.75246860774281	0.198427883842237	8	0.0701548511206711	0.614967626205525	0.889969589280094	0.656320063061916	0.668606953696366	0.715944812383098	0.433620270866152	0.673433436881321	1.07594901172031	0.937506582616738	0.858367730716573	0.638435371942911	0.619374390035639	0.616440076710891	0.645188675657706	0.485862118836736	0.631682068228117	0.821647621893988	0.792522123455921	0.725283067771021	p.Asp393Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.28	-3.52	2.24	2.28	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D393Q	393	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp393Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.28	-3.347	2.067	5.675	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D393R	393	D	R	missense	wt-like	0.944532334386477	0.199144970122961	8	0.0704083794065691	0.80653444653977	1.08253022223318	0.542149038707698	1.20987017021265	1.06337846769455	1.07853917887884	0.95426063228584	0.903382185568616	0.965044633890841	0.83963436785278	0.752643222992817	0.565054497513757	0.865953310303674	0.815588367403184	0.768692299898949	0.736581648736287	0.736594146086684	0.807353935925168	0.715874272672249	p.Asp393Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.28	-3.605	2.325	4.319	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
D393S	393	D	S	missense	wt-like	1.09529314258506	0.145552084068841	8	0.0514604328304558	0.994432547608524	1.1961537375616	1.13799159209216	1.12620018564306	1.00743107800621	1.13534235160973	1.39606526304717	0.926468611402984	1.06535767733724	0.967488381541922	0.810493137195769	0.84854239335142	0.827382855546032	0.788148832369334	0.793603418845506	0.901612390743566	0.747972814889774	0.861381878345903	0.780088702622877	p.Asp393Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.28	-3.026	1.746	4.737	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D393T	393	D	T	missense	wt-like	0.941643222204988	0.292839210892043	8	0.10353429590954	0.738719731057576	1.1445667133524	1.2582281711674	0.806541513560247	0.895278946084954	0.956498525211894	1.10477431521591	0.310079582876214	1.06060715011282	1.14113757341047	0.762973872998803	0.905748134383424	0.68002558743033	0.733143543112456	0.715171183143456	0.792804202885149	0.444171496323459	0.858823275770098	0.867303671832505	p.Asp393Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.28	-3.287	2.007	3.286	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
D393V	393	D	V	missense	wt-like	0.996386442229271	0.180070820217665	8	0.0636646490348673	0.871606023032549	1.12116686142599	0.635503071408026	1.11707430302755	1.0626058673664	1.16599650984245	1.15854993118383	0.862978897406918	1.03231394364119	0.936069013957805	0.809969138417808	0.609470154213423	0.823175977244864	0.815209443669841	0.807046847182854	0.812891429652763	0.716680468766249	0.843584741700855	0.764308386302665	p.Asp393Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.28	-3.529	2.249	2.724	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.785714285714286
D393W	393	D	W	missense	possibly_wt-like	0.916917250376803	0.338748256155152	8	0.119765594521213	0.682180998528198	1.15165350222541	1.02067826526559	1.07207731401101	1.19886614196	1.34531921324489	0.701936071833418	0.411487485039931	0.498593744886749	1.08637976677284	0.797580294842878	0.792727467098039	0.802433122587717	0.882038630862687	0.88568909513332	0.642328880569584	0.494152681848475	0.556126569000745	0.839801669845056	p.Asp393Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.28	-5.323	4.043	0.425	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
D393X	393	D	X	nonsense	possibly_wt-like	0.869046872834791	0.454971809582414	4	0.227485904791207	0.423182692453517	1.31491105321606	NA	NA	1.00482260977594	1.24079662169917	0.205665980523104	NA	NA	1.02490227934096	0.797897111969068	NA	NA	0.786869502702873	0.839850551520041	0.456953228748487	NA	NA	0.808924721235264	p.Asp393Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D393Y	393	D	Y	missense	wt-like	1.1799675874513	0.100511792068315	4	0.0502558960341574	1.08146784121356	1.27846733368903	NA	NA	NA	NA	1.17646375378393	1.03905862265656	1.24965211786829	1.25469585549641	0.871960509196854	NA	NA	NA	NA	0.819582920031184	0.803465356601597	0.960641646361949	0.924338098362524	p.Asp393Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.28	-4.163	2.883	1.396	NA	87.1	0.009078027	0	0.259465138	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.928571428571429
E394A	394	E	A	missense	wt-like	0.894097789389068	0.154497291900274	8	0.0546230413888204	0.78703859554094	1.0011569832372	1.00564908187379	1.01082252731589	0.94002231253721	1.07962971029913	0.740982073820215	0.624044741940358	0.936827647052676	0.814804220273279	0.762129295748083	0.785576934542588	0.774195696812312	0.755088037362113	0.769170554134053	0.656914039328999	0.598916348832506	0.79215645324692	0.703403379296275	p.Glu394Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.5	1.8	-5.3	214	121	93	12.3	8.1	4.2	147	89	58	3.22	6	2.78	-1.348	-3.022	1.674	3.56	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E394C	394	E	C	missense	possibly_low	0.570352365299003	0.220171439091077	6	0.0898846136179008	0.394181759843619	0.746522970754388	NA	0.866017608973574	0.800108330990098	NA	0.306716340353098	0.406203093423342	0.49966833880798	0.543400479245929	0.561898357949423	NA	0.707443066459418	0.686466880597268	NA	0.494699360639656	0.49154814953748	0.556705338186758	0.567091377712087	p.Glu394Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	170	-3.5	2.5	-6	214	148	66	12.3	5.5	6.8	147	121	26	3.22	5.07	1.85	-1.348	-5.087	3.739	0.656	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E394D	394	E	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu394Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	214	187	27	12.3	13	-0.699999999999999	147	133	14	3.22	5.05	1.83	-1.348	-1.636	0.288	34.947	34.947	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
E394E	394	E	E	synonymous	possibly_wt-like	0.897661675423255	0.350371326738838	5	0.156690820790966	0.590553309964941	1.20477004088157	NA	1.03457003785034	0.945755383159069	1.17059604647042	0.287486621862865	NA	NA	1.04990028777357	0.785142899508566	NA	0.785142899508566	0.757899835965343	0.809063981059888	0.48751633336906	NA	NA	0.821479922398557	p.Glu394=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	12.3	12.3	0	147	147	0	3.22	3.22	0	NA	NA	NA	NA	NA	NA	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
E394F	394	E	F	missense	possibly_wt-like	0.722412805317345	0.040212438296121	2	0.0284344878072328	0.666682233296325	0.778143377338364	NA	NA	NA	NA	0.693978317510112	NA	NA	0.750847293124577	0.655318747606633	NA	NA	NA	NA	0.639356358306918	NA	NA	0.671281136906348	p.Glu394Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	140	-3.5	2.8	-6.3	214	228	-14	12.3	5.2	7.1	147	165	-18	3.22	3.32	0.1	-1.348	-4.158	2.81	1.249	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E394G	394	E	G	missense	wt-like	0.902266544252755	0.175012093872838	8	0.0618761191835702	0.78099157914985	1.02354150935566	1.1222041338091	0.782225702711504	0.824378615116625	0.70424041533778	0.695093008815824	1.018949763217	0.950985151913847	1.12005556310036	0.745962275082906	0.841031091407866	0.668816407853432	0.698370301208688	0.60454300027631	0.639772737675721	0.793554248957124	0.799781591824929	0.856715273117324	p.Glu394Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.5	-9.4	5.9	214	97	117	12.3	9	3.3	147	75	72	3.22	3.29	0.07	-1.348	-3.133	1.785	4.143	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E394H	394	E	H	missense	wt-like	1.16399290929115	0.174647198794675	3	0.100832607237319	0.966364630638731	1.36162118794357	1.36345222313303	1.0900242818163	1.03850222292412	NA	NA	NA	NA	NA	0.810706372706403	0.955811267527931	0.810706372706403	0.803387751901884	NA	NA	NA	NA	NA	p.Glu394His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.5	-3.2	-0.3	214	216	-2	12.3	10.4	1.9	147	155	-8	3.22	7.59	4.37	-1.348	-4.174	2.826	1.567	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
E394I	394	E	I	missense	possibly_wt-like	0.910670239946177	0.346441314177476	6	0.141434074259009	0.633464548211757	1.1878759316806	0.623989867917427	NA	1.10671169483582	NA	1.24217450736829	0.352319506329112	1.00841732628742	1.13040853693899	0.833777718418635	0.603992442335744	NA	0.83684125535553	NA	0.844128372176395	0.464990401020386	0.830714181481739	0.861915034111591	p.Glu394Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	-3.5	4.5	-8	214	191	23	12.3	5.2	7.1	147	131	16	3.22	6.02	2.8	-1.348	-3.876	2.528	2.028	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
E394K	394	E	K	missense	wt-like	0.919180955796517	0.17734888828996	7	0.0670315791012871	0.787801474931147	1.05056043666189	0.697078867540308	1.13745741587836	0.928525931375391	0.920391251712271	1.09660433123284	0.680104780197676	NA	0.974104112638774	0.74944960891336	0.638766472143247	0.832572249230287	0.74944960891336	0.69933628270143	0.789752404816419	0.626546810688969	NA	0.783411440711678	p.Glu394Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.5	-3.9	0.4	214	230	-16	12.3	11.3	1	147	146	1	3.22	9.74	6.52	-1.348	-3.018	1.67	4.017	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E394L	394	E	L	missense	possibly_wt-like	0.734638744070628	0.225662359744184	8	0.0797836924168352	0.57826558038001	0.891011907761247	0.979460549478258	0.872242313161937	0.811143130462713	0.604931356607427	0.588752089685617	0.344875733323247	1.01164951914684	0.664055260698981	0.659784466215239	0.7731170457654	0.710312550331227	0.691878925169983	0.560990859514341	0.600050381756653	0.461321568595359	0.832455019200364	0.627690007260494	p.Glu394Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	138	-3.5	3.8	-7.3	214	191	23	12.3	4.9	7.4	147	131	16	3.22	9.71	6.49	-1.348	-3.527	2.179	2.497	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
E394M	394	E	M	missense	possibly_wt-like	0.770524876947057	0.267033322449711	6	0.10901589738698	0.556857644326262	0.984192109567851	1.13692958097479	0.932866648577972	0.597457997669889	0.632395837020687	0.413525083550209	NA	NA	0.909974113888795	0.662667937152299	0.848037113399008	0.738259348677191	0.587076525627407	0.573035449728013	0.534596466544384	NA	NA	0.751202273446293	p.Glu394Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.9	-5.4	214	203	11	12.3	5.7	6.6	147	149	-2	3.22	5.74	2.52	-1.348	-4.649	3.301	0.763	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
E394N	394	E	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu394Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-3.5	0	214	187	27	12.3	11.6	0.700000000000001	147	132	15	3.22	5.47	2.25	-1.348	-3.223	1.875	6.111	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E394P	394	E	P	missense	wt-like	0.908200866568953	0.174962594158413	7	0.0661296446974118	0.778589144651595	1.03781258848631	1.20161677010351	0.819089490709137	0.947224713023126	1.01991642982748	0.644561869789414	NA	0.831261026815251	0.893735765714752	0.742983202952711	0.878813759057485	0.685809993719047	0.758620472415152	0.742983202952711	0.620897445776605	NA	0.735298969077507	0.743046594627549	p.Glu394Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	93	-3.5	-1.6	-1.9	214	154	60	12.3	8	4.3	147	115	32	3.22	6.3	3.08	-1.348	-3.52	2.172	2.033	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E394Q	394	E	Q	missense	wt-like	1.22065253484511	0.0218303212637587	2	0.0154363682010846	1.19039780911888	1.25090726057133	NA	NA	NA	NA	1.20521616664402	NA	1.23608890304619	NA	0.891829811171118	NA	NA	NA	NA	0.830323033869791	NA	0.953336588472446	NA	p.Glu394Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	12.3	10.5	1.8	147	146	1	3.22	6.24	3.02	-1.348	-3.236	1.888	2.707	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
E394R	394	E	R	missense	possibly_wt-like	0.775305300581428	0.280760118271784	8	0.0992636917583578	0.580752039762561	0.969858561400294	0.488151386913607	0.936119754120842	0.975066975875824	0.921888816049516	0.33885491025544	1.12639964204946	0.535858195981223	0.880102723405513	0.718096233733394	0.539363682716572	0.739758975584122	0.77227577878823	0.699993041849584	0.506704332223807	0.846513359775679	0.576196956149834	0.736199425617203	p.Glu394Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	54	-3.5	-4.5	1	214	265	-51	12.3	10.5	1.8	147	174	-27	3.22	6.34	3.12	-1.348	-3.495	2.147	2.606	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
E394S	394	E	S	missense	wt-like	0.991543445946136	0.18024124777127	7	0.0681247882283935	0.858021314564067	1.12506557732821	NA	0.949027523709359	1.0906742967394	1.07036125239947	1.14137069311899	0.616175537267712	1.10611603433296	0.967078784055062	0.779882983080963	NA	0.74570924013236	0.8289756739697	0.765105857637551	0.806474334385846	0.595037832757468	0.883334060128775	0.779882983080963	p.Glu394Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	80	-3.5	-0.8	-2.7	214	143	71	12.3	9.2	3.1	147	105	42	3.22	5.68	2.46	-1.348	-3.026	1.678	4.605	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E394T	394	E	T	missense	wt-like	0.964162997400878	0.151510897083443	7	0.0572657363712987	0.851924216564967	1.07640177823679	1.08295071708246	1.01681122375442	1.03186339043528	0.638829584881545	1.01436102378541	NA	1.04240359271457	0.921921449152456	0.776956385083354	0.82235523744432	0.776956385083354	0.800131720160702	0.575856979768127	0.759031418416181	NA	0.84901896002834	0.757202799368384	p.Glu394Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.7	-2.8	214	163	51	12.3	8.6	3.7	147	119	28	3.22	5.6	2.38	-1.348	-3.287	1.939	3.115	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
E394V	394	E	V	missense	wt-like	1.04137667264016	0.0704606936000659	4	0.0352303468000329	0.972326461749236	1.11042688353108	1.05587748229429	1.11907820154262	1.04215669007757	0.94839431664614	NA	NA	NA	NA	0.807327261179176	0.809474428042539	0.824099740735583	0.805180094315813	0.711617069986685	NA	NA	NA	NA	p.Glu394Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.5	4.2	-7.7	214	165	49	12.3	5.9	6.4	147	117	30	3.22	5.61	2.39	-1.348	-3.473	2.125	2.161	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
E394W	394	E	W	missense	wt-like	1.05237479904027	0.24203406440759	8	0.0855719641103741	0.884656831297588	1.22009276678296	1.16768607188155	0.976736218055956	1.18110200837713	1.17332488939113	1.26936917138202	0.511701031878633	0.969935331866784	1.16914366948898	0.832273663611716	0.862670329574966	0.758482481901035	0.873326167805723	0.810260719328477	0.854286607894954	0.543545202251655	0.809988033541623	0.881369679171132	p.Glu394Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	-0.9	-2.6	214	264	-50	12.3	5.4	6.9	147	204	-57	3.22	5.89	2.67	-1.348	-5.267	3.919	0.266	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
E394X	394	E	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Glu394Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	12.3	NA	NA	147	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
E394Y	394	E	Y	missense	possibly_wt-like	0.822801944013539	0.41444349741477	3	0.239279064796307	0.353823594758351	1.29178029326873	NA	0.931387311608142	NA	1.17214316118052	0.364875359251954	NA	NA	NA	0.737577399230688	NA	0.737577399230688	NA	0.809742470600425	0.516423954215676	NA	NA	NA	p.Glu394Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	122	-3.5	-1.3	-2.2	214	255	-41	12.3	6.2	6.1	147	181	-34	3.22	5.66	2.44	-1.348	-4.107	2.759	0.983	NA	88.09	0.00942152	0	0.269282732	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
D395A	395	D	A	missense	wt-like	1.06472966423915	0.121059410123878	8	0.0428009649125188	0.980841314507049	1.14861801397125	0.877010529538516	1.2745274897899	1.11617461592958	1.08308878962092	1.06718116612286	1.00052938507171	0.960868780119919	1.13845655771979	0.794790098152311	0.724373731921374	0.895759246474613	0.841482368306846	0.770687538701778	0.778761739639516	0.784475347630139	0.805104848674483	0.865957136911166	p.Asp395Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	126	-3.5	1.8	-5.3	187	121	66	13	8.1	4.9	133	89	44	5.05	6	0.95	-1.34	-3.085	1.745	4.942	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D395C	395	D	C	missense	possibly_wt-like	0.991635789716265	0.359753468853365	5	0.160886642299495	0.676303765215675	1.30696781421685	1.27849710032348	1.20045211258528	1.1632639761354	NA	NA	0.922266630859768	NA	0.393699128677397	0.861611744239211	0.915391614938319	0.861611744239211	0.864577460969558	NA	NA	0.745901773436181	NA	0.491904165263912	p.Asp395Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	187	148	39	13	5.5	7.5	133	121	12	5.05	5.07	0.02	-1.34	-5.069	3.729	0.634	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D395E	395	D	E	missense	wt-like	0.932838779113282	0.172409000703167	8	0.0609557867674027	0.813367632399869	1.05230992582669	0.802072482523374	1.0862270248782	1.05358021052172	0.947807244135266	0.580852494154765	1.02304412974143	0.897209127417275	1.07191751953423	0.783195215367539	0.688719968782374	0.808955901164097	0.810782788046176	0.711359608432241	0.597099584002978	0.795572250399795	0.770818180335282	0.83253803427011	p.Asp395Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	45	-3.5	-3.5	0	187	214	-27	13	12.3	0.699999999999999	133	147	-14	5.05	3.22	-1.83	-1.34	-1.557	0.217	26.684	26.684	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	-0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
D395F	395	D	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp395Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	177	-3.5	2.8	-6.3	187	228	-41	13	5.2	7.8	133	165	-32	5.05	3.32	-1.73	-1.34	-4.18	2.84	1.409	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D395G	395	D	G	missense	wt-like	0.863999162984221	0.110383634817781	8	0.0390265083558363	0.787508612164431	0.940489713804012	0.92610840698946	0.835551262777151	0.848410665144718	0.934538711187942	0.661028839216269	0.885110030799023	0.789346090262791	1.03189929749642	0.711440370253472	0.747733349138379	0.693398593598038	0.710156879319919	0.705540672858642	0.627048481763806	0.7275883000136	0.712723861187024	0.812438960008398	p.Asp395Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.5	-9.4	5.9	187	97	90	13	9	4	133	75	58	5.05	3.29	-1.76	-1.34	-3.115	1.775	3.205	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D395H	395	D	H	missense	wt-like	1.10385061140692	0.15107101181707	3	0.0872208893393347	0.932900809602267	1.27480041321157	NA	0.957289390250638	1.09520255208667	1.25905989188344	NA	NA	NA	NA	0.831196567954848	NA	0.749517821564319	0.831196567954848	0.847859936806826	NA	NA	NA	NA	p.Asp395His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.5	-3.2	-0.3	187	216	-29	13	10.4	2.6	133	155	-22	5.05	7.59	2.54	-1.34	-4.237	2.897	2.261	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.642857142857143
D395I	395	D	I	missense	wt-like	1.03117370430199	0.044339523177325	3	0.0255994356421682	0.980999732418788	1.08134767618519	NA	NA	0.980830649815195	1.04827206833031	NA	NA	NA	1.06441839476046	0.775102586863889	NA	NA	0.775102586863889	0.755418611920023	NA	NA	NA	0.828771613423542	p.Asp395Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	-3.5	4.5	-8	187	191	-4	13	5.2	7.8	133	131	2	5.05	6.02	0.97	-1.34	-3.899	2.559	2.016	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
D395K	395	D	K	missense	wt-like	1.04814475752837	0.237246319992921	7	0.0896706803095028	0.872393453652544	1.22389606140421	1.24862788452492	1.09771123885114	0.854509037142392	0.982288507578576	1.27903503815802	NA	1.23356504342583	0.641276553017759	0.814249930531365	0.90118054342461	0.814249930531365	0.713147840882412	0.726481419658054	0.857897174772529	NA	0.95197725435634	0.616249445587413	p.Asp395Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	-3.9	0.4	187	230	-43	13	11.3	1.7	133	146	-13	5.05	9.74	4.69	-1.34	-3.12	1.78	6.834	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D395L	395	D	L	missense	possibly_wt-like	0.8580527118849	0.440886663613001	6	0.179991226708324	0.505276390003401	1.2108290337664	NA	1.04306132686805	1.09281850605127	1.20454940894829	-0.00486201751668663	0.987646593666039	NA	0.825102453292435	0.783591506208306	NA	0.789057240841082	0.830027306706465	0.823954280503703	0.378313057707404	0.77812577157553	NA	0.708575646820325	p.Asp395Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	172	-3.5	3.8	-7.3	187	191	-4	13	4.9	8.1	133	131	2	5.05	9.71	4.66	-1.34	-3.59	2.25	3.313	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
D395M	395	D	M	missense	possibly_wt-like	0.842271873434165	0.249385039756561	8	0.0881709263691705	0.669460033267057	1.01508371360127	0.74078717175697	1.09062305881456	0.974825557992648	1.04751724353492	0.581198435233923	0.979032954845631	0.386517210287768	0.937673355006896	0.760100872909973	0.659561856968706	0.81098239882545	0.772157374792975	0.755087582342664	0.597228806082171	0.773880344239569	0.49576288796793	0.765114163477281	p.Asp395Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	1.9	-5.4	187	203	-16	13	5.7	7.3	133	149	-16	5.05	5.74	0.69	-1.34	-4.712	3.372	1.123	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.875
D395N	395	D	N	missense	possibly_low	0.211184936509917	0.557833194942455	4	0.278916597471227	-0.335481549224144	0.757851422243979	1.03223482973593	NA	NA	NA	-0.182225270319053	-0.0838791416981843	0.0786093283209788	NA	0.32099345533916	0.798225809111714	NA	NA	NA	0.312061173555897	0.25	0.329925737122423	NA	p.Asp395Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	23	-3.5	-3.5	0	187	187	0	13	11.6	1.4	133	132	1	5.05	5.47	0.42	-1.34	-3.205	1.865	3.655	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
D395P	395	D	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp395Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	108	-3.5	-1.6	-1.9	187	154	33	13	8	5	133	115	18	5.05	6.3	1.25	-1.34	-3.543	2.203	2.351	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D395Q	395	D	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp395Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	187	214	-27	13	10.5	2.5	133	146	-13	5.05	6.24	1.19	-1.34	-3.337	1.997	5.852	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D395R	395	D	R	missense	wt-like	1.01373627971627	0.102291502620931	8	0.0361655075805108	0.942853187375855	1.08461937205668	0.924486065337239	1.02758822942539	1.01481162152771	1.17200773907458	0.924924218692492	0.960693546073962	1.16028764631024	0.92509117128852	0.773382876915495	0.746961477074684	0.781924403325421	0.79176863811282	0.809683081027152	0.72562338853245	0.764841350505569	0.912510532421841	0.758794786152342	p.Asp395Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	-4.5	1	187	265	-78	13	10.5	2.5	133	174	-41	5.05	6.34	1.29	-1.34	-3.596	2.256	4.455	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Deleterious	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
D395S	395	D	S	missense	possibly_wt-like	0.779860332752947	0.412353289566512	8	0.14578890364853	0.494119332256248	1.06560133324965	0.204143612107745	0.82600203372426	0.960982032462288	1.03761057778464	0.985245202097705	0.0532584779022274	1.07984919123713	1.09179153470758	0.749449278221614	0.404239452290383	0.688996559713968	0.765367783609215	0.75074299880966	0.748155557633567	0.317591387470391	0.869186911985334	0.842519719775029	p.Asp395Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-3.5	-0.8	-2.7	187	143	44	13	9.2	3.8	133	105	28	5.05	5.68	0.63	-1.34	-3.049	1.709	4.885	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D395T	395	D	T	missense	wt-like	1.00119176599507	0.363869814574984	8	0.128647406677531	0.749047482202629	1.25333604978751	0.224494969803274	1.18640650085032	0.734025240149996	1.14214140087146	1.10111513639577	1.39919558179621	1.16332704355625	1.05882825453727	0.811274564368127	0.413922150408828	0.855136953610847	0.654056265976047	0.796585152377978	0.791437361177799	0.980967028415239	0.914147531696905	0.825963976358276	p.Asp395Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.5	-0.7	-2.8	187	163	24	13	8.6	4.4	133	119	14	5.05	5.6	0.55	-1.34	-3.31	1.97	3.389	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
D395V	395	D	V	missense	wt-like	0.861037155788155	0.184499980632415	8	0.0652305937169837	0.733187541412702	0.988886770163608	1.12933116889862	0.898008430845328	0.908231300170857	0.609025107789281	0.591411560081884	0.934215389845927	0.818111971470279	0.999962317203066	0.733856515906452	0.844421967352548	0.722190296950873	0.73949605706692	0.562786180404459	0.601043794551096	0.751790990419653	0.728216974745984	0.796398673710713	p.Asp395Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	-3.5	4.2	-7.7	187	165	22	13	5.9	7.1	133	117	16	5.05	5.61	0.56	-1.34	-3.536	2.196	2.81	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
D395W	395	D	W	missense	wt-like	1.03286847266202	0.0898748301782896	5	0.040193245948981	0.954091158180255	1.11164578714378	0.933898957392651	1.06878924726886	0.939127035488632	1.10273020289023	NA	NA	NA	1.11979692026972	0.779301310762511	0.751439910089209	0.800917379156298	0.754648946529166	0.779301310762511	NA	NA	NA	0.856585370258188	p.Asp395Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	181	-3.5	-0.9	-2.6	187	264	-77	13	5.4	7.6	133	204	-71	5.05	5.89	0.84	-1.34	-5.329	3.989	0.438	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.345	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
D395X	395	D	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Asp395Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	187	NA	NA	13	NA	NA	133	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
D395Y	395	D	Y	missense	wt-like	0.91946180118986	0.149475908975957	6	0.0610232843049663	0.799858361733778	1.03906524064594	NA	0.914940859575549	0.805219795980794	0.941821110922444	0.739787886869286	NA	1.17529595188546	0.939705201905627	0.719365121058044	NA	0.729995861630197	0.688973811188093	0.708734380485891	0.656467965329576	NA	0.920593906643104	0.76613465463422	p.Asp395Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	160	-3.5	-1.3	-2.2	187	255	-68	13	6.2	6.8	133	181	-48	5.05	5.66	0.61	-1.34	-4.17	2.83	1.44	NA	85.11	0.009321394	0	0.266420958	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	0.345	Deleterious	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.857142857142857
Q396A	396	Q	A	missense	wt-like	1.08463662137823	0.0733000919738333	8	0.0259154960481476	1.03384318248237	1.13543006027409	1.03368171281486	1.01738545961452	1.08086943261849	1.00702300912714	1.18815977241423	1.19151587352365	1.11280290195379	1.04565480895919	0.821649732167651	0.798914202106204	0.777221098150723	0.82416685421874	0.737328773433151	0.823951825422157	0.878607371943953	0.886935562848474	0.819347638913146	p.Gln396Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-1.856	-3.13	1.274	3.96	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396C	396	Q	C	missense	possibly_low	0.6503583032802	0.449313235671523	7	0.169824440336658	0.31750851652568	0.983208090034721	0.802254034467679	0.308324516775458	0.132431612954432	0.133027403791244	1.20167998978149	NA	1.03328705341243	0.941503511778667	0.688806346934428	0.688806346934428	0.450355936684873	0.359003190193067	0.354036653705336	0.829002138046479	NA	0.844108852194201	0.767037852273777	p.Gln396Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-1.856	-4.986	3.13	1.318	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q396D	396	Q	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-1.856	-2.082	0.226	33.175	33.175	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396E	396	Q	E	missense	wt-like	0.96667840530674	0.191384982993623	8	0.0676648096460316	0.83405781537976	1.09929899523372	0.587058396792163	1.01676554645775	1.13476962688728	1.15996285071497	0.828005377813281	0.891902326960529	1.01972061198569	1.09524250484226	0.79066805264585	0.586421315567402	0.776935328618317	0.850602337218193	0.804400776673383	0.68942053525493	0.730936037293886	0.836802056476754	0.844252962819818	p.Gln396Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-1.856	-2.965	1.109	7.666	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
Q396F	396	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-1.856	-4.071	2.215	4.551	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q396G	396	Q	G	missense	wt-like	0.982154054168251	0.0886125191550344	8	0.0313292565962738	0.920749839577141	1.04355826875936	1.04128601677239	1.05000640587194	0.985507269561996	1.12692025638369	0.856619851062727	0.918459092398439	0.973808076852998	0.904625464441826	0.783653071269025	0.802532151371467	0.792258805379258	0.777396246534111	0.789909896003938	0.700109123431033	0.74402514171253	0.812073868403538	0.748515924654163	p.Gln396Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-1.856	-3.333	1.477	3.933	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396H	396	Q	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-1.856	-2.681	0.825	13.441	13.441	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000837537689196014	0.000721810580346055	0.000721810580346055	0.00135536660634847	0.00064735101899756	0.000485050429427799	0.000119027919304877	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
Q396I	396	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-1.856	-3.727	1.871	9.566	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q396K	396	Q	K	missense	wt-like	1.05804320880337	0.193920395954083	4	0.0969601979770413	0.868004712834492	1.24808170477224	NA	0.873835298668548	1.13201394999088	1.29664887522577	NA	NA	NA	0.92967471132826	0.80517383446514	NA	0.711046889840532	0.849250808698955	0.864344643383993	NA	NA	NA	0.761096860231326	p.Gln396Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-1.856	-3.163	1.307	10.519	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	D	0.5
Q396L	396	Q	L	missense	possibly_wt-like	0.711913638732187	0.460398270594034	8	0.1627753695918	0.392879776762062	1.03094750070231	1.0095206815809	1.07211251902751	0.999587304355156	1.14167723448343	-0.0308623793105087	0.0841708431024503	0.547978696892333	0.871124209726221	0.757995909417758	0.787418950773655	0.802449351507837	0.784301834268176	0.796381591493132	0.368600939045592	0.332827248060378	0.582724977859053	0.731689984567339	p.Gln396Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-1.856	-2.398	0.542	31.215	31.215	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Q396M	396	Q	M	missense	wt-like	1.06687048538216	0.116213946969986	8	0.0410878349854655	0.986339808607923	1.1474011621564	1.09428429641823	1.07375137370717	0.994451208846924	1.18111982260446	1.24328742090797	0.86875422969992	1.08202162859551	0.997293902277101	0.808442017618372	0.827747488366912	0.803204835933961	0.781782823579377	0.813679199302783	0.844544087482335	0.719526972329049	0.87035697239302	0.795058467498969	p.Gln396Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-1.856	-4.342	2.486	4.143	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q396N	396	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-1.856	-3.405	1.549	5.801	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396P	396	Q	P	missense	possibly_wt-like	0.845526947793868	0.284949703770688	8	0.100744933916676	0.648070505692315	1.04298338989542	0.952150034738548	0.969660246894927	0.948532229397444	0.977094179829064	0.207898199211741	0.966166689933271	0.657794363011408	1.08491963933454	0.757241162660877	0.760123344134277	0.755220578281275	0.759261747040479	0.724203439217974	0.457787046868214	0.767538913642173	0.641870970066401	0.839068323676247	p.Gln396Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-1.856	-3.748	1.892	1.929	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Q396R	396	Q	R	missense	wt-like	0.924350304245041	0.285976814778117	8	0.101108072495868	0.726182123606875	1.12251848488321	0.502650638819594	0.898036615594785	0.693684277313374	0.657986062640751	1.16175112316456	1.33619343952248	1.06605384511087	1.07844643179392	0.768145242798538	0.546262086314471	0.722203289646036	0.63427094141987	0.584258082613516	0.81408719595104	0.949914993078061	0.861756829709123	0.835817167766638	p.Gln396Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-1.856	-2.476	0.62	29.965	29.965	87.1	0.009442867	0	0.269892873	8.31e-06	2	240688	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.571428571428571
Q396S	396	Q	S	missense	possibly_wt-like	0.847653052769366	0.468199545874908	5	0.209385202322165	0.43726559732229	1.25804050821644	0.598937023100979	0.175800955744084	1.21215347517697	1.32079219895679	NA	0.930581610868006	NA	NA	0.75	0.592072887041445	0.389264805362496	0.888555436156812	0.874932735216079	NA	0.75	NA	NA	p.Gln396Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-1.856	-3.254	1.398	4.372	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396T	396	Q	T	missense	wt-like	0.910316823273329	0.205008240634065	8	0.0724813585757356	0.768255970914354	1.0523776756323	0.541426860295231	0.798798786289792	0.852502670814322	0.825615356887716	1.17620127120692	1.07743985540784	1.101470115249	0.909079670035805	0.731458427167764	0.564710901982678	0.676456320465336	0.712163813576464	0.657772167956891	0.81948487285958	0.822382418032604	0.880831798806264	0.750753040759064	p.Gln396Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-1.856	-3.428	1.572	3.004	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396V	396	Q	V	missense	wt-like	0.90845157973441	0.136432000566293	7	0.0515664491956337	0.807383196500354	1.00951996296847	0.962719378898097	0.940606965943286	0.994722411534381	0.69330536734043	0.747802818006841	NA	0.948603325915511	1.07140079050233	0.765151989905136	0.765151989905136	0.741827504716473	0.781915835605232	0.599747418123904	0.659461845295226	NA	0.798498756079216	0.832278508117857	p.Gln396Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-1.856	-3.47	1.614	7.966	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q396W	396	Q	W	missense	wt-like	1.08468852274472	0.0610374593124123	8	0.0215800006931024	1.04239249859989	1.12698454688955	1.11903155438195	1.0653879466619	1.07670435208604	1.11272983550449	1.12033490471135	1.00365864682228	1.00098341913523	1.17867752265453	0.81073675851733	0.83952165261221	0.799349436818881	0.822124080215779	0.783686665056994	0.798616671681772	0.786017675286806	0.826710328206226	0.886158038398925	p.Gln396Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-1.856	-5.187	3.331	0.615	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
Q396X	396	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln396Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q396Y	396	Q	Y	missense	wt-like	0.930469310748269	0.0545985561271285	3	0.0315224910773625	0.868686363533654	0.992252257962885	0.890656962873714	0.908040687547688	NA	NA	NA	NA	NA	0.992710281823407	0.730866384468444	0.730866384468444	0.726814998452205	NA	NA	NA	NA	NA	0.792756353032233	p.Gln396Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-1.856	-3.884	2.028	2.203	NA	87.1	0.009442867	0	0.269892873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
H397A	397	H	A	missense	wt-like	1.00406255343624	0.0939934487186482	8	0.0332317024880331	0.938929613414744	1.06919549345773	1.14637904866309	0.908569009998159	1.0088979871345	0.956581162453601	0.9013566896496	1.05771469342796	0.937735760909033	1.11526607525398	0.790756919466634	0.852532948240824	0.727058546210439	0.788868281563324	0.715207423833168	0.716820024931384	0.81266042438722	0.792645557369944	0.854309762152617	p.His397Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	86	-3.2	1.8	-5	216	121	95	10.4	8.1	2.3	155	89	66	7.59	6	-1.59	-1.629	-3.085	1.456	4.193	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H397C	397	H	C	missense	wt-like	0.942715850932166	0.150281651302441	8	0.053132587361934	0.838577893297347	1.04685380856698	0.720728629148588	1.02409205803493	0.976453312982218	0.793092736865458	0.79504072051925	1.11208197776276	1.07753471666545	1.04270265547868	0.776634219194563	0.650018473393094	0.780312727153439	0.772955711235687	0.643509322822054	0.677106988781062	0.83945657406441	0.867940351273016	0.817864925563694	p.His397Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	174	-3.2	2.5	-5.7	216	148	68	10.4	5.5	4.9	155	121	34	7.59	5.07	-2.52	-1.629	-4.75	3.121	1.441	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
H397D	397	H	D	missense	possibly_low	0.696731253213719	0.361796518473712	8	0.127914385811223	0.446023663919161	0.947438842508277	0.644032924971549	0.956428066438522	1.05480808895381	1.04121204038569	0.492928033968374	-0.0230124282746892	0.563179729575191	0.844273569691308	0.665866380514889	0.613528458248258	0.749120765782633	0.811385004046647	0.752322425783948	0.564256472150246	0.279999540775494	0.590912153627118	0.718204302781521	p.His397Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-3.2	-3.5	0.3	216	187	29	10.4	13	-2.6	155	133	22	7.59	5.05	-2.54	-1.629	-3.567	1.938	1.624	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
H397E	397	H	E	missense	possibly_wt-like	0.793824709785531	0.623823747344394	2	0.441110002012424	-0.0707350073792106	1.65838442695027	0.352714707773107	NA	NA	NA	NA	NA	NA	1.23493471179796	0.694669596662879	0.474926090989203	NA	NA	NA	NA	NA	NA	0.914413102336556	p.His397Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	40	-3.2	-3.5	0.3	216	214	2	10.4	12.3	-1.9	155	147	8	7.59	3.22	-4.37	-1.629	-3.349	1.72	1.769	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H397F	397	H	F	missense	wt-like	0.94991403842191	0.175945047722404	8	0.0622059681803511	0.827992581164977	1.07183549567884	0.823357522865468	1.09913297784387	1.05569330348312	1.11948396386396	1.02049837610503	0.701002125035398	1.06947260266608	0.710671435512365	0.77398632506377	0.698846891180121	0.814905328279774	0.811819159692237	0.786648698458546	0.761323951668994	0.63684654125265	0.863598149940243	0.651102890483686	p.His397Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	100	-3.2	2.8	-6	216	228	-12	10.4	5.2	5.2	155	165	-10	7.59	3.32	-4.27	-1.629	-3.624	1.995	4.782	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
H397G	397	H	G	missense	wt-like	0.995139939149484	0.0988689327170501	8	0.0349554463864513	0.926628523168518	1.06365135513045	0.850668706555541	1.01482947918986	0.942362304773049	1.05783601334922	1.15213909209634	0.909242262891408	0.95592713593335	1.0781145184071	0.767827864469531	0.711840911082119	0.776042834190979	0.756235692316025	0.759612894748082	0.810496738746798	0.73948241816028	0.802443311765592	0.835650464913025	p.His397Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	98	-3.2	-9.4	6.2	216	97	119	10.4	9	1.4	155	75	80	7.59	3.29	-4.3	-1.629	-3.422	1.793	1.843	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H397I	397	H	I	missense	wt-like	0.963004079744436	0.252760025598032	8	0.0893641640566268	0.787853536684919	1.13815462280395	1.10223934266155	1.01988358426852	1.00733491205533	1.04669465726135	1.05299347471037	0.344145258723617	1.02306137473828	1.10768003353649	0.783237179557906	0.831532312575927	0.778372691573881	0.78810166754193	0.754726835864613	0.773462100210345	0.460961537614475	0.838601369222502	0.850499687439949	p.His397Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.2	4.5	-7.7	216	191	25	10.4	5.2	5.2	155	131	24	7.59	6.02	-1.57	-1.629	-2.283	0.654	24.256	24.256	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.205	Deleterious	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
H397K	397	H	K	missense	wt-like	1.09208730717643	0.180019374233146	8	0.0636464601326083	0.967342537573057	1.21683207677981	1.21221787457351	0.950183057989432	1.02840387176852	0.950560214441576	1.42144555820247	0.899998825691535	1.23388774777921	1.04000130696522	0.807471584616858	0.883857515638286	0.746241921988341	0.798434990712095	0.71256692780297	0.911092891060245	0.734926580402885	0.952151060788928	0.816508178521621	p.His397Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.2	-3.9	0.7	216	230	-14	10.4	11.3	-0.9	155	146	9	7.59	9.74	2.15	-1.629	-3.479	1.85	2.175	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
H397L	397	H	L	missense	wt-like	0.99635001983267	0.0717227921221028	8	0.025357836337586	0.946649573885141	1.0460504657802	0.936527962702558	1.02769289892268	1.06955465167481	1.12150514859969	0.961402621867306	0.959200535124279	0.986465237055698	0.908451102714344	0.773039070192376	0.75269072908362	0.781972654202128	0.818617492044135	0.787535092139463	0.739249452009436	0.764105486182624	0.81889093126144	0.750437344043188	p.His397Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-3.2	3.8	-7	216	191	25	10.4	4.9	5.5	155	131	24	7.59	9.71	2.12	-1.629	-2.063	0.434	32.799	32.799	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.55	Deleterious	TOLERATED	effect	DAMAGING	null	D	D	T	D	D	B	0.5
H397M	397	H	M	missense	possibly_wt-like	0.792299463623071	0.211689906328133	8	0.0748436841366839	0.645608538244879	0.938990389001263	1.00921098666243	0.596881316219812	0.713838627447441	0.59118296133808	0.964280332912638	0.975436483769958	0.982551347337873	0.505013653296341	0.692240039005854	0.787271605203434	0.583375764945046	0.64415569206988	0.554961479579852	0.740324385941829	0.772107741866054	0.816782936118926	0.547811668965829	p.His397Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-3.2	1.9	-5.1	216	203	13	10.4	5.7	4.7	155	149	6	7.59	5.74	-1.85	-1.629	-4.162	2.533	4.353	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
H397N	397	H	N	missense	wt-like	0.933558476258681	0.173814607739183	7	0.065695746615446	0.804797178954938	1.06231977356242	NA	1.07352586139675	1.04630397546614	0.887160718657873	1.00147158178953	0.572041262019247	1.03924073596426	0.915165198516963	0.754216724253799	NA	0.803100878554129	0.807214140646644	0.684762981215308	0.754216724253799	0.573285253795284	0.847315466279967	0.753809485614334	p.His397Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.2	-3.5	0.3	216	187	29	10.4	11.6	-1.2	155	132	23	7.59	5.47	-2.12	-1.629	-3.417	1.788	1.308	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
H397P	397	H	P	missense	wt-like	1.03590059425259	0.105282043241727	8	0.0372228233567001	0.962945201070563	1.10885598743462	1.15953607784724	1.05148222070259	0.92865428724509	1.0291779210247	0.85837514375452	1.1731947973189	1.04771911149228	1.03906519463542	0.804488574550875	0.858792753784595	0.792939131178872	0.749512561365709	0.747044844191122	0.700764791649964	0.869577413831523	0.851881863321783	0.816038017922878	p.His397Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	77	-3.2	-1.6	-1.6	216	154	62	10.4	8	2.4	155	115	40	7.59	6.3	-1.29	-1.629	-3.862	2.233	1.324	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.642857142857143
H397Q	397	H	Q	missense	possibly_wt-like	0.817613179673284	0.330311082573531	8	0.116782603194407	0.588723483391415	1.04650287595515	0.673879145196664	0.813368497634885	1.07152797480411	1.1290038209762	0.305715795880482	1.10848552653364	0.391048951460915	1.04787572489938	0.736998179330396	0.627728589008079	0.683172712193607	0.819585313231879	0.790823646467186	0.494325619430917	0.837683981472723	0.498203653822066	0.820463089628789	p.His397Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	24	-3.2	-3.5	0.3	216	214	2	10.4	10.5	-0.0999999999999996	155	146	9	7.59	6.24	-1.35	-1.629	-3.773	2.144	1.428	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.5
H397R	397	H	R	missense	wt-like	0.975142832580292	0.0505289355311466	8	0.0178646764801058	0.940128710083825	1.01015695507676	0.970424731958616	0.913949460001203	0.92003326085627	1.02903086890681	0.992779227441394	0.933088811361096	0.990144816629153	1.0516914834878	0.751102765872522	0.768818015960854	0.729538843111242	0.745284357745459	0.746980354258186	0.750969801093687	0.751235730651357	0.820872728508309	0.82237954696567	p.His397Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.2	-4.5	1.3	216	265	-49	10.4	10.5	-0.0999999999999996	155	174	-19	7.59	6.34	-1.25	-1.629	-3.582	1.953	2.137	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	not specified	Uncertain significance(Last reviewed: Oct 28, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	D	D	D	D	D	B	0.571428571428571
H397S	397	H	S	missense	wt-like	0.993517292586874	0.230706085437439	8	0.0815669187369079	0.83364906953263	1.15338551564112	0.941575629021536	1.1040079468363	1.09197646418706	1.13597032916453	1.13084631476461	0.443865498937814	1.06296087898267	1.03693527880048	0.808755676395786	0.755092290193228	0.817152606941706	0.829614325200775	0.793878819370006	0.802543080958295	0.510110920654648	0.860090978588048	0.814968271833278	p.His397Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-3.2	-0.8	-2.4	216	143	73	10.4	9.2	1.2	155	105	50	7.59	5.68	-1.91	-1.629	-3.368	1.739	2.266	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
H397T	397	H	T	missense	wt-like	1.09426597818021	0.133461616010301	8	0.0471858068544995	1.00178349616393	1.18674846019649	0.873325522726416	1.17723292980665	1.11998189592801	1.27829076173862	1.20947739060694	1.07775362115667	1.06552927709189	0.952536426386485	0.837632210184389	0.722620492208339	0.850908091746869	0.843349658156873	0.856293664420555	0.831914762211904	0.822537064601254	0.861474300839979	0.772579112198221	p.His397Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-3.2	-0.7	-2.5	216	163	53	10.4	8.6	1.8	155	119	36	7.59	5.6	-1.99	-1.629	-3.428	1.799	3.545	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
H397V	397	H	V	missense	wt-like	1.00054095525419	0.0565340545574237	8	0.0199878066727623	0.961365574045625	1.03971633646275	1.08904136033692	0.967675043144612	1.00538270837807	0.991852916530766	0.913350074348825	0.981072343512113	0.983961968083951	1.07199122769825	0.78101485382949	0.825253022489545	0.754305432762483	0.787144204441441	0.730675905944767	0.72130000779775	0.77488550321754	0.817542687132635	0.832575054052268	p.His397Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	-3.2	4.2	-7.4	216	165	51	10.4	5.9	4.5	155	117	38	7.59	5.61	-1.98	-1.629	-2.969	1.34	15.747	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
H397W	397	H	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His397Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	115	-3.2	-0.9	-2.3	216	264	-48	10.4	5.4	5	155	204	-49	7.59	5.89	-1.7	-1.629	-5.032	3.403	0.646	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
H397X	397	H	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.His397Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.2	NA	NA	216	NA	NA	10.4	NA	NA	155	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
H397Y	397	H	Y	missense	wt-like	0.907592688563801	0.117749235180102	8	0.0416306413376899	0.825998130888624	0.989187246238977	0.825974631028148	0.960363695926347	1.03196537363424	0.808358342648076	1.10158591825605	0.848543528779477	0.762727505011671	0.921222513226399	0.730250347270775	0.70009204979124	0.750935024741612	0.800181738071747	0.650204077765473	0.791613216011173	0.709565669799938	0.69838726704274	0.756851760157578	p.His397Tyr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	83	-3.2	-1.3	-1.9	216	255	-39	10.4	6.2	4.2	155	181	-26	7.59	5.66	-1.93	-1.629	-3.397	1.768	1.951	NA	13.9	0.009505931	0	0.271695337	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	B	0.428571428571429
T398A	398	T	A	missense	possibly_wt-like	0.756832216217553	0.334001630604709	6	0.136355594706515	0.489580161502243	1.02408427093286	0.931927502712773	1.09994229686136	0.744526066678377	0.292229027936966	0.425908264249657	NA	NA	1.04646013886619	0.704854180223984	0.750501938244527	0.815278410726357	0.659206422203442	0.42385477133703	0.539222052961888	NA	NA	0.819752114294149	p.Thr398Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-2.054	-2.146	0.092	25.588	25.588	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
T398C	398	T	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-2.054	-4.859	2.805	1.893	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T398D	398	T	D	missense	possibly_wt-like	0.912294608198246	0.412203865676738	4	0.206101932838369	0.50834224269095	1.31624697370554	NA	1.02728397626194	NA	NA	0.303494602622342	1.11474992009541	NA	1.2036499338133	0.811277838858069	NA	0.781784147737515	NA	NA	0.493495919726546	0.840771529978624	NA	0.898700383381162	p.Thr398Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-2.054	-2.477	0.423	32.289	32.289	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398E	398	T	E	missense	wt-like	1.04028320707186	0.109095255534146	5	0.048788881479412	0.94465875652622	1.1359076576175	NA	1.13001304934265	1.04305548278862	1.09104511326685	0.853089723069285	NA	NA	1.0842126668919	0.805620909414075	NA	0.829140521542728	0.805620909414075	0.774176796699043	0.698790487089141	NA	NA	0.838713248140603	p.Thr398Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-2.054	-2.489	0.435	24.251	24.251	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398F	398	T	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-2.054	-4.188	2.134	2.44	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
T398G	398	T	G	missense	wt-like	0.990311833113196	0.0948961507755274	8	0.0335508558609382	0.924553363975262	1.05607030225113	0.952887815129727	1.00254623236534	0.976588272773322	0.96895599150261	0.852153312101883	1.16977857065232	0.931358079099667	1.06822639128069	0.771701183362028	0.760474362720475	0.770380464126505	0.77302190259755	0.720634424184778	0.698440702170618	0.867893649004776	0.789210580085476	0.830684172276756	p.Thr398Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-2.054	-3.189	1.135	6.922	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398H	398	T	H	missense	possibly_low	0.564040779235065	0.791741265821851	2	0.559845618007851	-0.533236468962893	1.66131802743302	NA	NA	NA	NA	0.00419516122721327	NA	NA	1.12388639724292	0.620167779350876	NA	NA	NA	NA	0.381696256579771	NA	NA	0.85863930212198	p.Thr398His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-2.054	-2.879	0.825	27.936	27.936	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398I	398	T	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-2.054	-3.841	1.787	3.795	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
T398K	398	T	K	missense	wt-like	1.09131320921775	0.081211682856033	5	0.0363189686866488	1.02012933863628	1.16249707979922	NA	1.19721828589046	1.02316071062087	1.14651948783244	1.00513306499672	NA	NA	1.08453449674824	0.798505169162252	NA	0.860121004556778	0.795863469416813	0.798505169162252	0.755584426736881	NA	NA	0.838874886560623	p.Thr398Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-2.054	-3.392	1.338	6.211	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
T398L	398	T	L	missense	wt-like	0.982843576981215	0.186378467138553	8	0.0658947389904125	0.853692261789339	1.11199489217309	0.614073267411141	0.78865998667627	1.0403331110544	1.07162222697193	1.03043661172682	1.18476838861294	1.04131025557961	1.09154476781661	0.784972287736682	0.599274356667942	0.671782504475028	0.804285715493638	0.765658859979726	0.765036258613537	0.875281720905387	0.848430095871249	0.842395781583513	p.Thr398Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-2.054	-3.431	1.377	5.259	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398M	398	T	M	missense	wt-like	1.10394614758105	0.168706968976022	7	0.0637652406220061	0.978968572496383	1.22892372266571	NA	1.04162337231264	0.934958620953082	1.0410892617694	1.46017943924058	1.02420673166261	1.09083237983302	1.13473322729598	0.796145265136066	NA	0.788394367991179	0.752604537356174	0.752268581032547	0.925561460838533	0.796145265136066	0.875102384795923	0.864087101440368	p.Thr398Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-2.054	-4.654	2.6	1.596	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T398N	398	T	N	missense	possibly_wt-like	0.811653697891953	0.308318448350264	6	0.125870479457466	0.564952091438531	1.05835530434538	0.719041149002244	1.07490948508195	0.820051239306386	0.620893215564329	0.392724261297711	NA	NA	1.24230283709909	0.672731769525265	0.649215609963422	0.803738705787233	0.696247929087109	0.567990957360412	0.526826572587465	NA	NA	0.918113728952532	p.Thr398Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-2.054	-2.569	0.515	26.485	26.485	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398P	398	T	P	missense	wt-like	1.09284096173315	0.198988982930573	8	0.070353229605811	0.954951165509684	1.23073075795662	0.93522241827092	1.21937577858557	1.08494285482002	0.876573075328918	1.41791610836745	1.19633893556109	1.17659240834738	0.835766114583851	0.848249954978002	0.752069581698719	0.870335235788393	0.826164674167611	0.680119753915649	0.909774508036173	0.880984527504304	0.921292169527662	0.713931449984078	p.Thr398Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-2.054	-2.599	0.545	44.808	44.808	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	D	D	T	D	D	B	0.428571428571429
T398Q	398	T	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-2.054	-3.753	1.699	5.319	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
T398R	398	T	R	missense	wt-like	0.998909434519889	0.10545794476278	8	0.037285013935879	0.925832150042492	1.07198671899729	0.95218437948017	0.984083769943909	1.03385078873632	1.14743827210331	0.996929108136808	0.819252121248462	0.933634139083594	1.12390289742654	0.77615301530998	0.760139684555887	0.761869579665323	0.801106444551089	0.798908103420276	0.752519938513536	0.695128734976724	0.790436450954636	0.858647589307144	p.Thr398Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-2.054	-3.714	1.66	4.049	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
T398S	398	T	S	missense	wt-like	0.936381192388599	0.280789148404523	8	0.0992739554602169	0.74180781508374	1.13095456969346	1.05926908749293	1.03371767168172	1.07159863303124	1.07990861833697	0.492164451977881	1.22536882488276	0.492006892787684	1.03701535891761	0.797919023603535	0.811088074157294	0.784749973049776	0.819619967733363	0.769292869683903	0.563971245392307	0.895292567144197	0.552578933980257	0.815008491916506	p.Thr398Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-2.054	-2.437	0.383	19.155	19.155	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	N	D	T	D	D	B	0.285714285714286
T398V	398	T	V	missense	wt-like	0.974170497218253	0.247004759834822	8	0.0873293703322785	0.803008076574426	1.14533291786208	1.16787556739913	0.932476335612839	0.90677778129374	0.41933835743133	1.19968206468891	1.00431900906569	1.09958358168265	1.06331128057174	0.807279358637748	0.862760487092657	0.73807942096906	0.738783175154588	0.479598763688516	0.828255837447647	0.78634314980208	0.879815724291963	0.828215567473415	p.Thr398Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-2.054	-3.435	1.381	6.032	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.125
T398W	398	T	W	missense	wt-like	1.23914205828998	0.307677083966131	2	0.217560552488154	0.812731210956564	1.6655529056234	NA	1.45670261077814	NA	NA	NA	NA	NA	1.02158150580183	0.89349789025043	NA	0.979738911323246	NA	NA	NA	NA	NA	0.807256869177614	p.Thr398Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-2.054	-5.349	3.295	0.479	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T398X	398	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Ter	0	0	no	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T398Y	398	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr398Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-2.054	-4.099	2.045	4.58	NA	90.57	0.009045738	0	0.258542268	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.25
Q399A	399	Q	A	missense	possibly_wt-like	0.895532467540533	0.406912108480242	6	0.166121172656105	0.569940952065007	1.22112398301606	NA	0.976615306219195	1.08821239472971	1.06125165468199	0.0754757955847188	1.16267354036807	NA	1.00896611365951	0.781015821252527	NA	0.758426743579181	0.827768228067019	0.761110829518778	0.408322269889087	0.864391773616162	NA	0.800920812986276	p.Gln399Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	91	-3.5	1.8	-5.3	214	121	93	10.5	8.1	2.4	146	89	57	6.24	6	-0.24	-1.607	-3.012	1.405	4.955	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399C	399	Q	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	154	-3.5	2.5	-6	214	148	66	10.5	5.5	5	146	121	25	6.24	5.07	-1.17	-1.607	-4.976	3.369	0.742	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q399D	399	Q	D	missense	wt-like	1.05011253662388	0.136171111974926	5	0.0608975725895341	0.930755487602478	1.16946958564528	NA	NA	1.10777491552775	0.823595412785396	NA	1.18658906129657	1.05242156655624	1.08018172695343	0.837362714561893	NA	NA	0.837362714561893	0.656886318357667	NA	0.876179080748548	0.854414574549589	0.836688716388763	p.Gln399Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	-3.5	-3.5	0	214	187	27	10.5	13	-2.5	146	133	13	6.24	5.05	-1.19	-1.607	-3.226	1.619	3.62	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399E	399	Q	E	missense	wt-like	0.944354954445777	0.153549010796436	8	0.0542877733893233	0.837952873801832	1.05075703508972	0.997900374227721	0.90416077214204	0.911591230760759	1.11503564131479	0.879820352415175	0.628345423851437	1.05437862139712	1.06360721945717	0.761517112345546	0.78189028139308	0.725026422747467	0.741143943298011	0.784697879748826	0.708775388305934	0.601036037494783	0.855468631356408	0.828364202203602	p.Gln399Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	-3.5	-3.5	0	214	214	0	10.5	12.3	-1.8	146	147	-1	6.24	3.22	-3.02	-1.607	-2.787	1.18	6.118	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0.345	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
Q399F	399	Q	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	116	-3.5	2.8	-6.3	214	228	-14	10.5	5.2	5.3	146	165	-19	6.24	3.32	-2.92	-1.607	-4.061	2.454	2.44	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q399G	399	Q	G	missense	possibly_wt-like	0.853616702545168	0.358216969235992	8	0.126648824041432	0.605389568739611	1.10184383635072	0.470948516997567	1.01711239147397	1.07205987584938	1.0936662299795	0.997633449819255	0.120537337465372	1.04302658643312	1.01394923234317	0.776210754903303	0.531178961153524	0.777095218333549	0.819846185409253	0.775326291473057	0.7527830367755	0.350751299962301	0.849354500328959	0.803423574662773	p.Gln399Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	87	-3.5	-9.4	5.9	214	97	117	10.5	9	1.5	146	75	71	6.24	3.29	-2.95	-1.607	-3.247	1.64	3.76	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399H	399	Q	H	missense	wt-like	0.906821490129807	0.216990426387777	8	0.0767177009756789	0.756457559240763	1.05718542101885	0.645327946062852	0.984863750779642	1.03648135230476	1.16991026897564	0.780274429890591	0.956141830969047	0.574394465691306	1.10717787636461	0.762413536070817	0.614144598874928	0.762229137703863	0.802396610930559	0.808763232282626	0.671591220657619	0.762597934437771	0.596952336402241	0.850247479976083	p.Gln399His	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	24	-3.5	-3.2	-0.3	214	216	-2	10.5	10.4	0.0999999999999996	146	155	-9	6.24	7.59	1.35	-1.607	-2.42	0.813	27.936	27.936	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
Q399I	399	Q	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Ile	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	-3.5	4.5	-8	214	191	23	10.5	5.2	5.3	146	131	15	6.24	6.02	-0.22	-1.607	-3.899	2.292	2.318	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q399K	399	Q	K	missense	wt-like	1.14366675819188	0.135657204209225	3	0.0783217233677081	0.990159001184064	1.2971745151997	NA	1.05452288119141	1.29978646201647	NA	NA	NA	NA	1.07669093136777	0.834935471088598	NA	0.794340824491243	0.931535250333996	NA	NA	NA	NA	0.834935471088598	p.Gln399Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.5	-3.9	0.4	214	230	-16	10.5	11.3	-0.800000000000001	146	146	0	6.24	9.74	3.5	-1.607	-2.088	0.481	23.857	23.857	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
Q399L	399	Q	L	missense	wt-like	1.02074568770602	0.132558719844477	8	0.0468665848537188	0.928888869314342	1.1126025060977	0.965751993298801	0.916931461623845	1.00489314520113	0.873765336892881	1.23737288599407	1.12562774259415	1.14209393939992	0.899528996643377	0.776749466801794	0.766594836627747	0.730913495673507	0.786904096975841	0.678888415897221	0.842334784959211	0.846132911614742	0.902711522087801	0.745956233605004	p.Gln399Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	113	-3.5	3.8	-7.3	214	191	23	10.5	4.9	5.6	146	131	15	6.24	9.71	3.47	-1.607	-3.292	1.685	3.647	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
Q399M	399	Q	M	missense	wt-like	1.02726848210205	0.140270870292533	7	0.0530174055686628	0.923356276633716	1.13118068757038	1.06983388974605	0.99829646485992	0.849791638050134	1.00047988890659	1.27353243859384	NA	1.10193589934106	0.897009155216744	0.768421392828217	0.816114558995722	0.768421392828217	0.710834180881798	0.734459277976131	0.855841745685061	NA	0.881082667040757	0.744690648144616	p.Gln399Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.5	1.9	-5.4	214	203	11	10.5	5.7	4.8	146	149	-3	6.24	5.74	-0.5	-1.607	-4.277	2.67	1.346	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q399N	399	Q	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	46	-3.5	-3.5	0	214	187	27	10.5	11.6	-1.1	146	132	14	6.24	5.47	-0.77	-1.607	-3.282	1.675	4.305	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399P	399	Q	P	missense	wt-like	1.13258811306942	0.088018285812477	7	0.0332677850122884	1.06738445259991	1.19779177353892	1.267207434731	1.11316953316751	1.03672956119342	1.13720287336951	1.22580052317102	NA	1.11413339643274	1.03387346942072	0.821375944054938	0.910020257143639	0.821375944054938	0.802518345591172	0.794419353530703	0.838012069689851	NA	0.88765215838411	0.813430484021496	p.Gln399Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	76	-3.5	-1.6	-1.9	214	154	60	10.5	8	2.5	146	115	31	6.24	6.3	0.06	-1.607	-3.589	1.982	2.335	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
Q399Q	399	Q	Q	synonymous	wt-like	0.824997652125747	0.0512618435347648	2	0.036247597179556	0.753953667127701	0.896041637123792	NA	NA	NA	NA	0.861245249305303	NA	0.788750054946191	NA	0.70711986257301	NA	NA	NA	NA	0.701836884642445	NA	0.712402840503575	NA	p.Gln399=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-3.5	-3.5	0	214	214	0	10.5	10.5	0	146	146	0	6.24	6.24	0	NA	NA	NA	NA	NA	NA	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q399R	399	Q	R	missense	wt-like	0.908612500670653	0.255161934970515	8	0.0902133672591658	0.731797549918603	1.0854274514227	0.304687721321396	0.886453031824511	0.912142462672169	1.04973266549187	1.03308303360899	1.11936443790143	0.979317014914651	0.984119637630202	0.761041978175339	0.452075978563891	0.716863452474546	0.74141429634628	0.756059159056306	0.766024797294372	0.843045899782658	0.815040946045375	0.788441718678113	p.Gln399Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	43	-3.5	-4.5	1	214	265	-51	10.5	10.5	0	146	174	-28	6.24	6.34	0.1	-1.607	-3.135	1.528	9.23	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	N	D	T	D	D	B	0.357142857142857
Q399S	399	Q	S	missense	wt-like	1.00253245727076	0.213591557886118	5	0.0955210485706883	0.815314642306705	1.18975027223481	1.14653826745236	1.1397917647452	1.04119891561358	NA	0.630158545738914	NA	NA	1.05497479280373	0.824028582690015	0.852608700802119	0.833648344771835	0.804710351471589	NA	0.615517259400267	NA	NA	0.824028582690015	p.Gln399Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	-3.5	-0.8	-2.7	214	143	71	10.5	9.2	1.3	146	105	41	6.24	5.68	-0.56	-1.607	-3.095	1.488	4.592	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399T	399	Q	T	missense	wt-like	1.14416657064952	0.174341675650581	8	0.0616390905479756	1.02335617313569	1.26497696816336	1.2147971777083	1.25801318060914	1.19569022303511	1.24835521383403	1.38397043740209	1.03363965020065	0.935738977844805	0.883127704562045	0.861823188677967	0.885084687504841	0.888146427870821	0.880480993605797	0.843165383750137	0.897094515846652	0.800794493070309	0.79157010320452	0.737718716525429	p.Gln399Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-3.5	-0.7	-2.8	214	163	51	10.5	8.6	1.9	146	119	27	6.24	5.6	-0.64	-1.607	-3.356	1.749	3.474	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
Q399V	399	Q	V	missense	wt-like	0.985395700416144	0.166095923632566	8	0.0587237769640153	0.870299212530511	1.10049218830178	0.914379909881164	0.828560118582432	0.940870151421805	0.767050016237213	1.24937954327708	1.17282518170342	1.06918729159852	0.940913390627524	0.761122663551484	0.742153205612739	0.690175793782145	0.755503862030726	0.632088247553325	0.84681972563769	0.869395240388861	0.863444483284342	0.766741465072241	p.Gln399Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	-3.5	4.2	-7.7	214	165	49	10.5	5.9	4.6	146	117	29	6.24	5.61	-0.63	-1.607	-3.463	1.856	2.866	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
Q399W	399	Q	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	130	-3.5	-0.9	-2.6	214	264	-50	10.5	5.4	5.1	146	204	-58	6.24	5.89	-0.35	-1.607	-5.032	3.425	0.457	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
Q399X	399	Q	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Gln399Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.5	NA	NA	214	NA	NA	10.5	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Q399Y	399	Q	Y	missense	possibly_wt-like	0.740034779019088	0.30994026909613	7	0.117146410473257	0.510432033573359	0.969637524464817	0.461949060484808	1.01468272123082	0.891965151684974	0.945536517221008	0.176046641229684	0.749717613944826	NA	0.940345747337492	0.710363777644334	0.526897231062256	0.775975181241736	0.731518284489315	0.710363777644334	0.445889285093267	0.660857075315302	NA	0.766456367332773	p.Gln399Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	99	-3.5	-1.3	-2.2	214	255	-41	10.5	6.2	4.3	146	181	-35	6.24	5.66	-0.58	-1.607	-3.669	2.062	4.58	NA	86.1	0.009898817	0	0.282924662	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.345	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.375
I400A	400	I	A	missense	wt-like	1.01592516658646	0.200014473240142	8	0.0707157951817797	0.87732475489206	1.15452557828086	1.05739875709059	0.86415975998473	1.03275174519747	0.586338476426328	1.14473304702514	1.14387873643644	1.18101548165988	1.1171253288711	0.808964257814496	0.810198214869351	0.70658662934234	0.800567415941244	0.552836923255451	0.80773030075964	0.855128328044667	0.923674407590031	0.855243568669223	p.Ile400Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	1.8	2.7	191	121	70	5.2	8.1	-2.9	131	89	42	6.02	6	-0.02	-1.302	-2.888	1.586	5.984	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	neutral	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
I400C	400	I	C	missense	wt-like	1.08704013330186	0.133602296873305	3	0.0771353220641548	0.935857680120216	1.2382225864835	NA	1.1738281750906	0.933190462567021	1.15410176224795	NA	NA	NA	NA	0.801830387293024	NA	0.84933855712329	0.751737339721932	0.801830387293024	NA	NA	NA	NA	p.Ile400Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	198	4.5	2.5	2	191	148	43	5.2	5.5	-0.3	131	121	10	6.02	5.07	-0.95	-1.302	-4.508	3.206	1.607	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400D	400	I	D	missense	low	-0.019943589647132	0.296721192748437	2	0.20981356751418	-0.431170625442789	0.391283446148524	NA	NA	NA	NA	-0.229757157161312	NA	0.189869977867048	NA	0.342078101829259	NA	NA	NA	NA	0.294306215802135	NA	0.389849987856384	NA	p.Ile400Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	168	4.5	-3.5	8	191	187	4	5.2	13	-7.8	131	133	-2	6.02	5.05	-0.97	-1.302	-3.789	2.487	1.554	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400E	400	I	E	missense	possibly_wt-like	0.797019462378019	0.267739338901449	8	0.0946601510638088	0.611488975521833	0.982549949234205	1.02488927069557	0.961662956528721	0.9554773582975	0.784657580140079	0.286094130055029	1.06569303986053	0.547963191598071	0.749718171848644	0.711123999976378	0.794730964602415	0.751533962013324	0.762668002610744	0.63981007183982	0.486996185004181	0.816592733455065	0.582716626810008	0.670714037939431	p.Ile400Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	134	4.5	-3.5	8	191	214	-23	5.2	12.3	-7.1	131	147	-16	6.02	3.22	-2.8	-1.302	-3.7	2.398	2.006	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400F	400	I	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile400Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.5	2.8	1.7	191	228	-37	5.2	5.2	0	131	165	-34	6.02	3.32	-2.7	-1.302	-3.538	2.236	3.042	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I400G	400	I	G	missense	wt-like	1.0163458610664	0.075510814288588	8	0.0266971044181893	0.96402049791524	1.06867122421755	1.06883710276697	0.878214712391255	1.00594157397801	1.0092549923587	1.08844141236577	1.01096984444324	1.11210809567514	0.956999154552079	0.787060773643409	0.815640311156773	0.713065725863098	0.787418301451044	0.738307613119302	0.786703245835773	0.789621164925248	0.886561344777454	0.774820508748156	p.Ile400Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	135	4.5	-9.4	13.9	191	97	94	5.2	9	-3.8	131	75	56	6.02	3.29	-2.73	-1.302	-3.619	2.317	2.151	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
I400H	400	I	H	missense	wt-like	1.0892208262746	0.118198689867664	8	0.0417895475663954	1.00731481811424	1.17112683443496	0.852916089464514	1.18627657825041	1.02590152711574	1.17221176520603	1.1567836800707	1.0050954896883	1.13817141815117	1.17641006224994	0.811002112525239	0.712910163099094	0.855077061478827	0.79720770961553	0.809772557001547	0.812231668048932	0.786725855895264	0.90059887805976	0.885019210816472	p.Ile400His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	4.5	-3.2	7.7	191	216	-25	5.2	10.4	-5.2	131	155	-24	6.02	7.59	1.57	-1.302	-4.775	3.473	0.766	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I400K	400	I	K	missense	wt-like	1.05716371505371	0.181432130021161	8	0.0641459447315413	0.931439973625592	1.18288745648183	0.895139137322119	1.0438829763015	1.24498433142431	1.22194544183201	0.721127650293473	1.19990625346473	1.00135848414943	1.12896544564211	0.829247836640256	0.732998897824428	0.789436007401905	0.904657410443878	0.831583337535736	0.649497661096162	0.882742761075494	0.826912335744775	0.86119024431171	p.Ile400Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	4.5	-3.9	8.4	191	230	-39	5.2	11.3	-6.1	131	146	-15	6.02	9.74	3.72	-1.302	-3.717	2.415	2.286	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400L	400	I	L	missense	possibly_wt-like	0.74247370474355	0.720107004635518	3	0.415753972971651	-0.0723891087103249	1.55733651819743	1.13227113145332	NA	NA	-0.0885048563686491	NA	NA	NA	1.18365483914598	0.845820732502401	0.845820732502401	NA	NA	0.256883339585243	NA	NA	NA	0.888657885935658	p.Ile400Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	5	4.5	3.8	0.7	191	191	0	5.2	4.9	0.3	131	131	0	6.02	9.71	3.69	-1.302	-2.379	1.077	11.193	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	neutral	neutral	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
I400M	400	I	M	missense	wt-like	0.99884246764783	0.332369374634545	6	0.135689228997096	0.732896465723514	1.26478846957215	NA	1.08459078937242	1.0727021574526	1.14318006545942	0.335303702796466	1.26160989622032	NA	1.09566819458575	0.81418140906806	NA	0.808201624133056	0.820161194003064	0.797040660333825	0.505377821904152	0.913154801462225	NA	0.844466764666357	p.Ile400Met	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	10	4.5	1.9	2.6	191	203	-12	5.2	5.7	-0.5	131	149	-18	6.02	5.74	-0.28	-1.302	-3.9	2.598	2.73	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	D	D	D	D	D	D	0.714285714285714
I400N	400	I	N	missense	wt-like	1.07398931671143	0.148734540130984	7	0.0562163720788773	0.963807252095325	1.18417138132753	NA	0.960392118315285	1.10264195241195	1.27242832799113	0.808743982345357	1.12697278506967	1.09518964681435	1.15155640403226	0.846795846317793	NA	0.750948126984576	0.834845240162674	0.853722685065374	0.682225675434901	0.846795846317793	0.877449180003117	0.872536509268153	p.Ile400Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	4.5	-3.5	8	191	187	4	5.2	11.6	-6.4	131	132	-1	6.02	5.47	-0.55	-1.302	-3.993	2.691	1.419	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	D	D	D	D	D	D	0.785714285714286
I400P	400	I	P	missense	wt-like	0.942780234054041	0.150766279819766	8	0.0533039294174127	0.838306452161448	1.04725401594664	0.711318134489563	1.11499883788192	0.896621280510406	1.00433274354244	0.75730324867087	1.06719484447598	1.08060612310512	0.909866659756034	0.743648629065815	0.645541181003476	0.822219222741891	0.733801894336696	0.73614895331473	0.663010615526927	0.817332931935707	0.869594590488296	0.751148304816901	p.Ile400Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	4.5	-1.6	6.1	191	154	37	5.2	8	-2.8	131	115	16	6.02	6.3	0.28	-1.302	-3.915	2.613	1.47	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400Q	400	I	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Ile400Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.5	-3.5	8	191	214	-23	5.2	10.5	-5.3	131	146	-15	6.02	6.24	0.22	-1.302	-4.16	2.858	1.377	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
I400R	400	I	R	missense	possibly_wt-like	0.879068059850992	0.26122838767163	8	0.0923581821805188	0.698049349099586	1.0600867706024	1.03555691683907	1.03582779191023	0.899552669789178	1.082809706978	0.421034774133422	1.13880984176515	0.548376597019962	0.870576180372924	0.752902374002567	0.799806380148997	0.785722702962727	0.735239601426532	0.770565146578602	0.537401620050939	0.852630008292783	0.582939284238823	0.731414737889486	p.Ile400Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.5	-4.5	9	191	265	-74	5.2	10.5	-5.3	131	174	-43	6.02	6.34	0.32	-1.302	-4.028	2.726	1.867	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
I400S	400	I	S	missense	wt-like	1.05258349230269	0.151549353566961	8	0.053580787795818	0.947567077959605	1.15759990664578	1.26707057170319	1.0302814110403	1.0198262643722	0.881382045517118	1.1630748429305	1.1241325329412	1.12879201374261	0.806108256174422	0.804404868700209	0.909955140928706	0.783165914724833	0.79422808204363	0.682228735203301	0.814581655356788	0.845395963611006	0.895547192816081	0.699035848224181	p.Ile400Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	142	4.5	-0.8	5.3	191	143	48	5.2	9.2	-4	131	105	26	6.02	5.68	-0.34	-1.302	-3.481	2.179	2.785	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
I400T	400	I	T	missense	wt-like	0.833669160866865	0.1779487411737	8	0.0629143807937664	0.710359240401444	0.956979081332286	0.745389471942093	0.794726213073981	0.650663247576147	0.935433837405671	0.81600236116903	0.592735849471504	1.04409431587074	1.09030799042575	0.6797579436226	0.661751523329531	0.674578932752458	0.613171171453069	0.705933231841002	0.684936954492743	0.583485050780977	0.849929572349454	0.841774612542059	p.Ile400Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	4.5	-0.7	5.2	191	163	28	5.2	8.6	-3.4	131	119	12	6.02	5.6	-0.42	-1.302	-3.232	1.93	4.298	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
I400V	400	I	V	missense	wt-like	1.07036197473969	0.113672972522873	8	0.0401894648542776	0.991592071067365	1.14913187841201	1.00660840778076	0.972029095125664	1.02052318857987	1.10780994704283	1.11026772342434	1.22865870657959	1.2099901530311	0.907008576353337	0.7903016247602	0.786033359283059	0.756312577448973	0.794569890237341	0.781529040389568	0.794856198653561	0.896914059985843	0.93927997415168	0.74971283798125	p.Ile400Val	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.5	4.2	0.3	191	165	26	5.2	5.9	-0.7	131	117	14	6.02	5.61	-0.41	-1.302	-1.793	0.491	23.182	23.182	86.1	0.009814621	0	0.280518209	0	NA	NA	PTEN hamartoma tumor syndrome	Uncertain significance(Last reviewed: Jan 26, 2015)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	neutral	neutral	neutral	0.205	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
I400W	400	I	W	missense	wt-like	0.91212295943782	0.218962364394663	8	0.0774148863440531	0.760392570336215	1.06385334853943	1.10129007242923	1.1286641000149	1.07347145362305	0.92832458250756	0.977516441689871	0.587963499746221	0.570101613917339	0.929651911574392	0.753176991179936	0.831080672089336	0.828518678604861	0.820538497204124	0.702815457148605	0.745268573260625	0.581132889934335	0.594640234800134	0.761085409099247	p.Ile400Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	61	4.5	-0.9	5.4	191	264	-73	5.2	5.4	-0.2	131	204	-73	6.02	5.89	-0.13	-1.302	-5.193	3.891	0.42	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
I400X	400	I	X	nonsense	wt-like	0.926873411700567	0.175584518197298	7	0.0663647098890208	0.796800970473637	1.0569458529275	NA	0.745552066929723	0.877984542289335	0.64765191636283	0.995215899145855	1.11223630472093	1.05163273037463	1.05784042208068	0.751879990148796	NA	0.651910478959147	0.724661460186283	0.579726026836279	0.751879990148796	0.83953263760742	0.8539897125941	0.825467839426345	p.Ile400Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.5	NA	NA	191	NA	NA	5.2	NA	NA	131	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
I400Y	400	I	Y	missense	wt-like	1.07136003332964	0.261905365169661	7	0.09899092332464	0.877341388816976	1.2653786778423	1.39978385254097	1.1164496780659	1.17863048883337	1.04749415712109	0.581743418453705	NA	0.930649327084342	1.24476931120808	0.822888035649705	0.973097003692139	0.822888035649705	0.872114004959777	0.755077457760299	0.597432377930178	NA	0.788828850932826	0.919352510781324	p.Ile400Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	33	4.5	-1.3	5.8	191	255	-64	5.2	6.2	-1	131	181	-50	6.02	5.66	-0.36	-1.302	-3.808	2.506	1.829	NA	86.1	0.009814621	0	0.280518209	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0.55	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T401A	401	T	A	missense	wt-like	0.927675718203817	0.266843148061989	8	0.0943432997538991	0.742766248503508	1.11258518790413	1.21272336253527	0.944622392611778	0.771154803843183	0.501930241896705	1.23215005629177	0.916872455787725	1.16411033924489	0.677842093419223	0.743460840345485	0.884098014941057	0.743678548832788	0.672266551914787	0.51581956191196	0.840383860498181	0.743243131858181	0.914569409579485	0.634614417205946	p.Thr401Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	1.8	-2.5	163	121	42	8.6	8.1	0.5	119	89	30	5.6	6	0.4	-1.32	-2.752	1.432	4.041	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401C	401	T	C	missense	wt-like	1.05322571575139	0.381824195476048	7	0.144315980825277	0.77037159094028	1.33607984056251	1.22558354468132	NA	0.773393218056118	0.434230380725238	1.65866059182739	1.09322490568678	1.01584988260616	1.17163748667676	0.834717307207279	0.890216587634404	NA	0.673364387677246	0.486129683455743	0.999701679399428	0.830162438225109	0.834717307207279	0.882622194008122	p.Thr401Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	149	-0.7	2.5	-3.2	163	148	15	8.6	5.5	3.1	119	121	-2	5.6	5.07	-0.53	-1.32	-4.587	3.267	0.677	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T401D	401	T	D	missense	possibly_wt-like	0.927719743527403	0.314348243645195	4	0.157174121822597	0.619664125453401	1.23577536160141	NA	1.25789932085173	1.13405108526081	0.637885407165055	0.681043160832018	NA	NA	NA	0.742387257344825	NA	0.888093940438868	0.850249926708198	0.575442909175387	0.634524587981452	NA	NA	NA	p.Thr401Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-0.7	-3.5	2.8	163	187	-24	8.6	13	-4.4	119	133	-14	5.6	5.05	-0.55	-1.32	-3.309	1.989	2.318	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
T401E	401	T	E	missense	possibly_wt-like	0.936363596276682	0.610909438687203	4	0.305454719343601	0.337683347455433	1.53504384509793	NA	1.05589724122423	1.23222016408105	1.41114087447715	0.0461961053242955	NA	NA	NA	0.846685787238612	NA	0.794974381336501	0.898397193140723	0.914555286111506	0.397385197995807	NA	NA	NA	p.Thr401Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	214	-51	8.6	12.3	-3.7	119	147	-28	5.6	3.22	-2.38	-1.32	-3.28	1.96	2.664	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401F	401	T	F	missense	wt-like	1.02914609242328	0.158405347769793	8	0.056004747792117	0.919378803787482	1.13891338105908	0.767382064028845	1.00242220333905	0.94634280941079	1.02152241016516	0.965839106217675	1.31669123283303	1.08593847236579	1.1270304410259	0.764255614724838	0.672215082233265	0.770323288832736	0.75818794061694	0.74368750810495	0.740906646735945	0.940302888006422	0.872466558568667	0.860218392002997	p.Thr401Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-0.7	2.8	-3.5	163	228	-65	8.6	5.2	3.4	119	165	-46	5.6	3.32	-2.28	-1.32	-4.016	2.696	0.984	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
T401G	401	T	G	missense	wt-like	0.874866349168587	0.159231552512084	8	0.0562968552800782	0.76452654037677	0.985206157960404	1.00769401127773	0.876545520953763	0.733801474496023	0.705704514231604	1.02712801615776	0.641025031429009	0.990195485037466	1.01683673976535	0.738048314857182	0.786549863935706	0.71229625670217	0.65394651956007	0.605185083102675	0.763800373012193	0.607285469789476	0.820900018178255	0.804873819655036	p.Thr401Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	59	-0.7	-9.4	8.7	163	97	66	8.6	9	-0.4	119	75	44	5.6	3.29	-2.31	-1.32	-3.198	1.878	2.556	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401H	401	T	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr401His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	47	-0.7	-3.2	2.5	163	216	-53	8.6	10.4	-1.8	119	155	-36	5.6	7.59	1.99	-1.32	-4.52	3.2	0.895	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T401I	401	T	I	missense	possibly_wt-like	0.810557333119805	0.336050334727844	8	0.118811735253034	0.577690611083151	1.04342405515646	0.993197484502	1.00291539764403	1.04814705442948	0.816329640348352	0.323554616886668	0.275004794266057	0.842371873346772	1.18293780353508	0.755916920357935	0.779652756890796	0.770550643107091	0.80811808326249	0.653699902657345	0.500989093876879	0.426884090910568	0.741283197608779	0.888297756193308	p.Thr401Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	89	-0.7	4.5	-5.2	163	191	-28	8.6	5.2	3.4	119	131	-12	5.6	6.02	0.42	-1.32	-3.51	2.19	1.886	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	2	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401K	401	T	K	missense	wt-like	0.887948825766253	0.0725791580234164	3	0.0419035964223758	0.805819285955695	0.970078365576811	NA	0.969818076740165	NA	NA	0.831496356095389	NA	NA	0.862532044463206	0.727374586258862	NA	0.755293335183722	NA	NA	0.690724547698699	NA	NA	0.727374586258862	p.Thr401Lys	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-0.7	-3.9	3.2	163	230	-67	8.6	11.3	-2.7	119	146	-27	5.6	9.74	4.14	-1.32	-3.297	1.977	2.955	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401L	401	T	L	missense	wt-like	0.9883923894625	0.267755796253015	8	0.0946659696162554	0.802850498453076	1.17393428047192	1.11015425114587	1.02732728555875	1.01743733815504	1.00712694564464	0.363345388508773	1.28025406291421	1.06908445165737	1.03240939211535	0.802875790668856	0.835298040181688	0.78180411259447	0.793056427298089	0.737374354953091	0.515852452267945	0.922344002053147	0.86338909437151	0.812695154039623	p.Thr401Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	3.8	-4.5	163	191	-28	8.6	4.9	3.7	119	131	-12	5.6	9.71	4.11	-1.32	-3.083	1.763	2.651	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401M	401	T	M	missense	wt-like	0.961292106053855	0.327296552615934	8	0.115716805906853	0.734491334070411	1.1880928780373	1.11560400994655	0.505312476744539	0.954853421577267	1.15667651204712	1.35069816232009	0.425405777362496	1.02961118841059	1.15217530002219	0.820425227619084	0.837890907452499	0.541164071010129	0.762361991309965	0.80295954778567	0.88466606249253	0.501012628025475	0.842129055591059	0.872847348576562	p.Thr401Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	81	-0.7	1.9	-2.6	163	203	-40	8.6	5.7	2.9	119	149	-30	5.6	5.74	0.14	-1.32	-4.379	3.059	0.765	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
T401N	401	T	N	missense	wt-like	1.1975533357312	0.381400872170016	4	0.190700436085008	0.823787349168504	1.5713193222939	NA	0.736546352968395	NA	NA	1.65945922740996	1.26961243571307	1.12459532683338	NA	0.905192959801735	NA	0.64775899638517	NA	NA	1	0.917099034628719	0.893286884974751	NA	p.Thr401Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	65	-0.7	-3.5	2.8	163	187	-24	8.6	11.6	-3	119	132	-13	5.6	5.47	-0.13	-1.32	-3.397	2.077	1.612	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401P	401	T	P	missense	wt-like	1.23378598558334	0.106778828831494	7	0.0403586037678381	1.15468457573205	1.31288739543462	1.35739447210711	1.39155646428906	1.0981503424299	1.17512381395708	1.22272104942796	1.2369469476782	1.15460880919406	NA	0.900999107671344	0.952929131832704	0.949707634172696	0.832642318987129	0.811049640469387	0.836861769757656	0.900999107671344	0.909451948271781	NA	p.Thr401Pro	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	38	-0.7	-1.6	0.9	163	154	9	8.6	8	0.6	119	115	4	5.6	6.3	0.7	-1.32	-2.007	0.687	35.724	35.724	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401Q	401	T	Q	missense	wt-like	0.965190675222442	0.139906889032379	2	0.0989291099695093	0.771293182659601	1.15908816778528	NA	NA	NA	0.866261565252933	NA	NA	NA	1.06411978519195	0.752109631313812	NA	NA	NA	0.675597625279659	NA	NA	NA	0.828621637347965	p.Thr401Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	42	-0.7	-3.5	2.8	163	214	-51	8.6	10.5	-1.9	119	146	-27	5.6	6.24	0.64	-1.32	-3.739	2.419	1.586	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401R	401	T	R	missense	wt-like	0.901669692517907	0.056044926383202	8	0.0198148737483315	0.862833253612969	0.940506131422844	0.921079130762181	0.977433558747047	0.828618462876083	0.894544243729334	0.975275178922483	0.831937779153359	0.888717282606843	0.895751903345921	0.744245286335373	0.745340537602581	0.758803944223692	0.700449744982239	0.688001037514934	0.744431376835369	0.701381149312521	0.766244528826952	0.744059195835378	p.Thr401Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	71	-0.7	-4.5	3.8	163	265	-102	8.6	10.5	-1.9	119	174	-55	5.6	6.34	0.74	-1.32	-3.607	2.287	1.795	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401S	401	T	S	missense	wt-like	0.98221217907215	0.143204435568802	8	0.0506304137433461	0.88297839161283	1.08144596653147	0.835154124366705	0.947391972968292	1.11206247047059	1.11246357849997	1.11609707887274	1.03679091478437	0.972202601248766	0.725534691365762	0.790301790530745	0.704459437176754	0.744955278766325	0.839465556441005	0.783569897637307	0.797033683424183	0.802347665322537	0.811209169850656	0.658567931856238	p.Thr401Ser	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	58	-0.7	-0.8	0.1	163	143	20	8.6	9.2	-0.6	119	105	14	5.6	5.68	0.08	-1.32	-2.885	1.565	3.122	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
T401T	401	T	T	synonymous	wt-like	0.942204699715845	0.17119347779795	8	0.0605260345229197	0.823575851923895	1.0608335475078	0.72012082560138	1.10778970804636	1.00890054768987	1.0411247213272	1.00498859576063	0.645338340753531	0.920136665605922	1.08923819294188	0.769348631465575	0.649729294737253	0.818895935214172	0.788869537394008	0.752284131876271	0.755530462012271	0.609411382158984	0.783166800918879	0.841237308834438	p.Thr401=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	-0.7	-0.7	0	163	163	0	8.6	8.6	0	119	119	0	5.6	5.6	0	NA	NA	NA	NA	NA	NA	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
T401V	401	T	V	missense	wt-like	1.36119396400347	0.27838605355943	3	0.160726262961175	1.04617627722986	1.67621165077709	NA	NA	NA	NA	1.65945922740996	NA	1.31587447838582	1.10824818621464	0.996308572198152	NA	NA	NA	NA	1	NA	0.996308572198152	0.850785041018609	p.Thr401Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	-0.7	4.2	-4.9	163	165	-2	8.6	5.9	2.7	119	117	2	5.6	5.61	0.01	-1.32	-3.028	1.708	2.333	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
T401W	401	T	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr401Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	128	-0.7	-0.9	0.2	163	264	-101	8.6	5.4	3.2	119	204	-85	5.6	5.89	0.29	-1.32	-5.047	3.727	0.265	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
T401X	401	T	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr401Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-0.7	NA	NA	163	NA	NA	8.6	NA	NA	119	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Deleterious	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
T401Y	401	T	Y	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Thr401Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	92	-0.7	-1.3	0.6	163	255	-92	8.6	6.2	2.4	119	181	-62	5.6	5.66	0.06	-1.32	-4.062	2.742	0.847	NA	72.21	0.013264303	0	0.379115873	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0.55	Neutral	TOLERATED	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.5
K402A	402	K	A	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Ala	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	106	-3.9	1.8	-5.7	230	121	109	11.3	8.1	3.2	146	89	57	9.74	6	-3.74	-1.325	-2.977	1.652	3.445	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K402C	402	K	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	202	-3.9	2.5	-6.4	230	148	82	11.3	5.5	5.8	146	121	25	9.74	5.07	-4.67	-1.325	-4.927	3.602	0.775	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K402D	402	K	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Asp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	101	-3.9	-3.5	-0.4	230	187	43	11.3	13	-1.7	146	133	13	9.74	5.05	-4.69	-1.325	-3.158	1.833	6.575	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K402E	402	K	E	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Glu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	56	-3.9	-3.5	-0.4	230	214	16	11.3	12.3	-1	146	147	-1	9.74	3.22	-6.52	-1.325	-2.889	1.564	3.906	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K402F	402	K	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Phe	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	2.8	-6.7	230	228	2	11.3	5.2	6.1	146	165	-19	9.74	3.32	-6.42	-1.325	-4.132	2.807	1.326	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K402G	402	K	G	missense	wt-like	1.1865215921242	0.0376236047114943	3	0.0217219983080653	1.14394725776815	1.22909592648024	NA	1.18036870814195	1.22684239134581	1.15235367688483	NA	NA	NA	NA	0.852353632785678	NA	0.852353632785678	0.895759651260849	0.801063761762865	NA	NA	NA	NA	p.Lys402Gly	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	127	-3.9	-9.4	5.5	230	97	133	11.3	9	2.3	146	75	71	9.74	3.29	-6.45	-1.325	-3.048	1.723	5.053	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
K402H	402	K	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	-3.9	-3.2	-0.7	230	216	14	11.3	10.4	0.9	146	155	-9	9.74	7.59	-2.15	-1.325	-4.145	2.82	2.528	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
K402I	402	K	I	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	102	-3.9	4.5	-8.4	230	191	39	11.3	5.2	6.1	146	131	15	9.74	6.02	-3.72	-1.325	-3.85	2.525	1.757	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
K402L	402	K	L	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Leu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	107	-3.9	3.8	-7.7	230	191	39	11.3	4.9	6.4	146	131	15	9.74	9.71	-0.03	-1.325	-3.258	1.933	2.42	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K402M	402	K	M	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	95	-3.9	1.9	-5.8	230	203	27	11.3	5.7	5.6	146	149	-3	9.74	5.74	-4	-1.325	-4.379	3.054	0.936	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K402N	402	K	N	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Asn	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	94	-3.9	-3.5	-0.4	230	187	43	11.3	11.6	-0.299999999999999	146	132	14	9.74	5.47	-4.27	-1.325	-2.055	0.73	24.992	24.992	78.91	0.013380131	0	0.382426438	0	NA	NA	not specified	Uncertain significance(Last reviewed: Dec 1, 2016)	criteria provided, single submitter	0	0	1	0	0	0	0	0	0	0	0	0	0	0.000237510687980959	0.000181099428760659	0.000181099428760659	0.000222308808448691	0.00020890610573228	0.000176621623759035	0.00013064039923706	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	B	0.357142857142857
K402P	402	K	P	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	103	-3.9	-1.6	-2.3	230	154	76	11.3	8	3.3	146	115	31	9.74	6.3	-3.44	-1.325	-3.554	2.229	1.52	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
K402Q	402	K	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Gln	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	53	-3.9	-3.5	-0.4	230	214	16	11.3	10.5	0.800000000000001	146	146	0	9.74	6.24	-3.5	-1.325	-3.349	2.024	2.705	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
K402R	402	K	R	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Arg	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	26	-3.9	-4.5	0.6	230	265	-35	11.3	10.5	0.800000000000001	146	174	-28	9.74	6.34	-3.4	-1.325	-2.982	1.657	3.497	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	D	D	D	D	0.571428571428571
K402S	402	K	S	missense	wt-like	1.18536697267974	0.177517789311583	5	0.0793883688232371	1.02976862899481	1.34096531636467	0.948350064039874	1.2025649651351	1.15692600110541	1.44725050337904	NA	NA	NA	1.17174332973928	0.862585733706303	0.758315407303493	0.862585733706303	0.861468985509886	0.930391219518827	NA	NA	NA	0.882675353480613	p.Lys402Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	-3.9	-0.8	-3.1	230	143	87	11.3	9.2	2.1	146	105	41	9.74	5.68	-4.06	-1.325	-2.931	1.606	5.561	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
K402T	402	K	T	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Thr	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	78	-3.9	-0.7	-3.2	230	163	67	11.3	8.6	2.7	146	119	27	9.74	5.6	-4.14	-1.325	-3.192	1.867	3.952	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	neutral	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	B	0.571428571428571
K402V	402	K	V	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Val	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	-3.9	4.2	-8.1	230	165	65	11.3	5.9	5.4	146	117	29	9.74	5.61	-4.13	-1.325	-3.428	2.103	2.123	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
K402W	402	K	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	110	-3.9	-0.9	-3	230	264	-34	11.3	5.4	5.9	146	204	-58	9.74	5.89	-3.85	-1.325	-5.222	3.897	0.286	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.75
K402X	402	K	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Lys402Ter	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	-3.9	NA	NA	230	NA	NA	11.3	NA	NA	146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
K402Y	402	K	Y	missense	possibly_wt-like	0.906269746665661	0.459523640527679	3	0.265306097557652	0.386279350573793	1.42626014275753	1.38625720616907	NA	NA	NA	NA	0.470390833085747	0.862161200742172	NA	0.751941598593642	0.966661342969469	NA	NA	NA	NA	0.523184533448852	0.751941598593642	NA	p.Lys402Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	85	-3.9	-1.3	-2.6	230	255	-25	11.3	6.2	5.1	146	181	-35	9.74	5.66	-4.08	-1.325	-4.003	2.678	1.238	NA	78.91	0.013380131	0	0.382426438	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.625
V403A	403	V	A	missense	wt-like	1.03820657589995	0.251694773049279	4	0.125847386524639	0.791550230763163	1.28486292103673	1.15048963466916	0.665531535718681	1.21664473430425	1.1201603989077	NA	NA	NA	NA	0.820717009315386	0.854488668541266	0.615022360781106	0.890758185254769	0.786945350089505	NA	NA	NA	NA	p.Val403Ala	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	64	4.2	1.8	2.4	165	121	44	5.9	8.1	-2.2	117	89	28	5.61	6	0.39	-1.329	-2.752	1.423	3.525	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000252511363011336	0.000289759086017054	0.000289759086017054	0.000196014218202072	0.000296595088385336	0.000337426385688903	0.000119027919304877	deleterious	neutral	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V403C	403	V	C	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Cys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	192	4.2	2.5	1.7	165	148	17	5.9	5.5	0.4	117	121	-4	5.61	5.07	-0.54	-1.329	-4.477	3.148	1.251	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V403D	403	V	D	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Asp	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	152	4.2	-3.5	7.7	165	187	-22	5.9	13	-7.1	117	133	-16	5.61	5.05	-0.56	-1.329	-3.818	2.489	1.213	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000140006300283513	3.62198857521318e-05	3.62198857521318e-05	0.000186452549021483	6.4477193127247e-05	0.000118626463718755	8.41904795083276e-05	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
V403E	403	V	E	missense	possibly_low	0.704013461259204	0.306756823732019	5	0.137185822085343	0.435134190782412	0.972892731735996	NA	1.02936933351742	0.726324044933041	0.235483083273259	0.617441968338496	NA	NA	0.9114488762338	0.650279195818971	NA	0.78274546233665	0.650279195818971	0.398968749847539	0.610767136703346	NA	NA	0.751942969968558	p.Val403Glu	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	121	4.2	-3.5	7.7	165	214	-49	5.9	12.3	-6.4	117	147	-30	5.61	3.22	-2.39	-1.329	-3.564	2.235	1.598	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403F	403	V	F	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Phe	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	50	4.2	2.8	1.4	165	228	-63	5.9	5.2	0.7	117	165	-48	5.61	3.32	-2.29	-1.329	-3.612	2.283	4.32	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000362516313234096	0.000685590694593923	0.000685590694593923	0.00101831776773271	0.000590611089045583	0.000279431225648623	7.54811195591903e-05	deleterious	neutral	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.642857142857143
V403G	403	V	G	missense	wt-like	0.970619167687377	0.182521828190323	8	0.0645312112139718	0.844140317829245	1.09709801754551	0.784662503247509	0.959788010077806	1.04753559299069	1.02528497493522	0.970727238473095	1.26700795029096	1.04862747433418	0.661319597149565	0.748003614968861	0.680436709449086	0.750669643253973	0.807818190494211	0.745337586683748	0.742732549039756	0.915815354892696	0.852371101546779	0.626316025558289	p.Val403Gly	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	109	4.2	-9.4	13.6	165	97	68	5.9	9	-3.1	117	75	42	5.61	3.29	-2.32	-1.329	-3.483	2.154	1.665	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	9.75043876974464e-05	0.000144879543008527	0.000144879543008527	3.58562594272082e-05	0.000144428912605033	5.79951600402803e-05	4.64499197287325e-05	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	D	D	D	D	D	D	0.714285714285714
V403H	403	V	H	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403His	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	84	4.2	-3.2	7.4	165	216	-51	5.9	10.4	-4.5	117	155	-38	5.61	7.59	1.98	-1.329	-4.745	3.416	0.787	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V403I	403	V	I	missense	wt-like	1.02659010392382	0.0445489925451753	4	0.0222744962725876	0.982932893455777	1.07024731439186	NA	1.07725770658561	0.977118545577619	1.04765405195197	NA	NA	NA	1.00433011158008	0.785937183074961	NA	0.804821196380886	0.773281976200127	0.75514757988481	NA	NA	NA	0.798592389949796	p.Val403Ile	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	29	4.2	4.5	-0.3	165	191	-26	5.9	5.2	0.7	117	131	-14	5.61	6.02	0.41	-1.329	-2.56	1.231	9.081	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.00117255276487442	0.00139446560145707	0.00139446560145707	0.000614337244852834	0.0014262355119747	0.00163440905568063	0.00253442374519897	neutral	neutral	neutral	0	Neutral	*DAMAGING	neutral	DAMAGING	null	D	D	D	D	D	D	0.5
V403K	403	V	K	missense	possibly_wt-like	0.851351227325454	0.290675588389868	5	0.129994075007899	0.596567522106375	1.10613493254453	NA	0.424676118150624	1.049857623673	NA	1.14915684626061	NA	0.929226865836809	0.703838682706229	0.788062722703265	NA	0.503992066772687	0.80895703615997	NA	0.809382757115887	NA	0.788062722703265	0.647671153663078	p.Val403Lys	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	97	4.2	-3.9	8.1	165	230	-65	5.9	11.3	-5.4	117	146	-29	5.61	9.74	4.13	-1.329	-3.522	2.193	1.965	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403L	403	V	L	missense	wt-like	1.33010628445406	0.0944577753536462	3	0.0545352220274808	1.2232192133913	1.43699335551682	NA	1.43601368237722	1.29973551319503	1.25456965778993	NA	NA	NA	NA	0.931510262359068	NA	0.970201663515965	0.931510262359068	0.845890737724736	NA	NA	NA	NA	p.Val403Leu	1	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	32	4.2	3.8	0.4	165	191	-26	5.9	4.9	1	117	131	-14	5.61	9.71	4.1	-1.329	-1.817	0.488	29.631	29.631	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0.000475021375961918	3.62198857521318e-05	3.62198857521318e-05	0.000337048838615757	5.67399299519774e-05	0.000205619203779176	4.35467997456867e-05	neutral	neutral	neutral	0	Neutral	TOLERATED	neutral	DAMAGING	null	D	D	T	D	D	D	0.428571428571429
V403M	403	V	M	missense	wt-like	1.05318617448471	0.165063384254962	3	0.0952993893329528	0.866402803643465	1.23996954532596	NA	0.863892527202101	1.12854940028911	1.16711659596293	NA	NA	NA	NA	0.807538062677275	NA	0.706463439526958	0.847551611766838	0.807538062677275	NA	NA	NA	NA	p.Val403Met	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	21	4.2	1.9	2.3	165	203	-38	5.9	5.7	0.2	117	149	-32	5.61	5.74	0.13	-1.329	-3.8	2.471	3.933	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	*DAMAGING	neutral	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.25
V403N	403	V	N	missense	wt-like	0.841877644615955	0.14786409130616	8	0.0522778508282863	0.739414939803356	0.944340349428553	0.905093805378848	0.91377914822346	0.932085988083955	0.910818878315368	0.845849808404186	0.989644308765405	0.688439350311887	0.549309869444529	0.712773218670478	0.737735095138861	0.729460332247974	0.751195647492127	0.695138303595213	0.696086105092982	0.779110390790375	0.658376157751581	0.570059357457186	p.Val403Asn	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	133	4.2	-3.5	7.7	165	187	-22	5.9	11.6	-5.7	117	132	-15	5.61	5.47	-0.14	-1.329	-3.963	2.634	1.092	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403P	403	V	P	missense	possibly_wt-like	1.06206507647325	0.426946364228878	3	0.246497598317075	0.578938661496159	1.54519149145033	NA	0.581180464972336	1.20845584983602	1.39655891461139	NA	NA	NA	NA	0.88674192670355	NA	0.576137936758361	0.88674192670355	0.908160345138562	NA	NA	NA	NA	p.Val403Pro	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	68	4.2	-1.6	5.8	165	154	11	5.9	8	-2.1	117	115	2	5.61	6.3	0.69	-1.329	-3.779	2.45	1.129	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403Q	403	V	Q	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Gln	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-3.5	7.7	165	214	-49	5.9	10.5	-4.6	117	146	-29	5.61	6.24	0.63	-1.329	-3.964	2.635	1.29	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403R	403	V	R	missense	wt-like	0.968624768783959	0.237574213676321	7	0.0897946124727523	0.792630562331633	1.14461897523628	NA	1.05118023897494	1.08158518816773	1.18957151452069	0.463149187515737	1.0824757959599	0.929002504291138	0.983408952057573	0.792799922684647	NA	0.792799922684647	0.824517898290295	0.817385701818446	0.553132946537282	0.824864495599098	0.787941883057149	0.788084778230147	p.Val403Arg	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	96	4.2	-4.5	8.7	165	265	-100	5.9	10.5	-4.6	117	174	-57	5.61	6.34	0.73	-1.329	-3.928	2.599	1.93	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403S	403	V	S	missense	wt-like	1.06111292630278	0.250915984981438	7	0.0948373280331004	0.875235178967897	1.24699067363767	1.34009083553063	1.25382135077001	0.980115266849467	0.961379678794427	NA	0.591387614749291	1.21999331010523	1.08100242732044	0.837100911553442	0.944696467858733	0.886214064861632	0.774751725526836	0.717311820569942	NA	0.582820542706711	0.944667608459829	0.837100911553442	p.Val403Ser	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	124	4.2	-0.8	5	165	143	22	5.9	9.2	-3.3	117	105	12	5.61	5.68	0.07	-1.329	-3.451	2.122	1.937	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
V403T	403	V	T	missense	wt-like	0.976471693049309	0.105173005224659	8	0.0371842725960623	0.903591857969708	1.04935152812891	1.12579407421848	0.905408217720427	0.879617789835296	0.830438899085204	1.02417918127139	0.940768148323746	1.00707632177584	1.09849091216409	0.758859768876079	0.842739100758757	0.725601474165144	0.725462490466802	0.659887539821673	0.762698871634729	0.755020666117428	0.829991925311966	0.84588446908544	p.Val403Thr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	69	4.2	-0.7	4.9	165	163	2	5.9	8.6	-2.7	117	119	-2	5.61	5.6	-0.01	-1.329	-3.096	1.767	2.652	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	neutral	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.375
V403V	403	V	V	synonymous	possibly_wt-like	0.716055909322446	0.427971866034613	3	0.24708967206067	0.231769051131719	1.20034276751317	0.985406268947319	NA	NA	NA	0.222566423852316	NA	NA	0.940195035167702	0.766380672438335	0.775945879476505	NA	NA	NA	0.463266183635505	NA	NA	0.766380672438335	p.Val403=	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	0	4.2	4.2	0	165	165	0	5.9	5.9	0	117	117	0	5.61	5.61	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA		NA	Neutral	TOLERATED	neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA
V403W	403	V	W	missense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Trp	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	88	4.2	-0.9	5.1	165	264	-99	5.9	5.4	0.5	117	204	-87	5.61	5.89	0.28	-1.329	-5.093	3.764	0.584	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	pathogenic	NA	NA	NA	NA	NA	NA	0.625
V403X	403	V	X	nonsense	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	p.Val403Ter	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	4.2	NA	NA	165	NA	NA	5.9	NA	NA	117	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	Neutral	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
V403Y	403	V	Y	missense	wt-like	1.17987207920055	0.0623346965499455	4	0.0311673482749728	1.11878519908799	1.24095895931312	NA	1.18188947618051	1.1267806572689	1.14405032622176	NA	NA	NA	1.26676785713106	0.849869404327466	NA	0.853054681257595	0.846684127397338	0.797422314532397	NA	NA	NA	0.930401237727211	p.Val403Tyr	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	55	4.2	-1.3	5.5	165	255	-90	5.9	6.2	-0.3	117	181	-64	5.61	5.66	0.05	-1.329	-3.778	2.449	1.763	NA	78.91	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	deleterious	deleterious	neutral	0	Neutral	*DAMAGING	effect	DAMAGING	null	NA	NA	NA	NA	NA	NA	0.5
WT	NA	Z	Z	wt	wt-like	1	0	8	0	1	1	1	1	1	1	1	1	1	1	0.783551831109865	0.782889234033923	0.769206693858049	0.784504241863385	0.734248821956538	0.753667032788971	0.784214428185808	0.826180665157549	0.796417599822254	p.NA	0	0	NA	1	0	1	1	1	40.3	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	0	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA